Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Cyclopentanophenanthrenes with a 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. They are found in BUFONIDAE and often possess cardiotonic properties.
Contractile activity of the MYOCARDIUM.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.
Venoms produced by frogs, toads, salamanders, etc. The venom glands are usually on the skin of the back and contain cardiotoxic glycosides, cholinolytics, and a number of other bioactive materials, many of which have been characterized. The venoms have been used as arrow poisons and include bufogenin, bufotoxin, bufagin, bufotalin, histrionicotoxins, and pumiliotoxin.
A cardiotonic cardiac glycoside found in STROPHANTHUS. The aglycone is STROPHANTHIN.
The aglycone constituents of CARDIAC GLYCOSIDES. The ring structure is basically a cyclopentanoperhydrophenanthrene nucleus attached to a lactone ring at the C-17 position.
3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.
A plant genus of the family MORACEAE. Members have been used as an arrow poison.
3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide. The aglycone cardioactive agent isolated from Strophanthus Kombe, S. gratus and other species; it is a very toxic material formerly used as digitalis. Synonyms: Apocymarin; Corchorin; Cynotoxin; Corchorgenin.
Stable cesium atoms that have the same atomic number as the element cesium, but differ in atomic weight. Cs-133 is a naturally occurring isotope.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
A plant family of the order Theales.
Compounds of the general formula R:N.NR2, as resulting from the action of hydrazines with aldehydes or ketones. (Grant & Hackh's Chemical Dictionary, 5th ed)
A plant species which is known as an Oriental traditional medicinal plant.
Pyridine derivatives with one or more keto groups on the ring.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
The order Actiniaria, in the class ANTHOZOA, comprised of large, solitary polyps. All species are carnivorous.
One of the three polypeptide chains that make up the TROPONIN complex of skeletal muscle. It is a calcium-binding protein.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
The hollow, muscular organ that maintains the circulation of the blood.
Surgery performed on the heart.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Chromatographic techniques in which the mobile phase is a liquid.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Individual's rights to obtain and use information collected or generated by others.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The period of history before 500 of the common era.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Drugs used to cause dilation of the blood vessels.

Thioridazine lengthens repolarization of cardiac ventricular myocytes by blocking the delayed rectifier potassium current. (1/2962)

Proarrhythmia has been observed with the antipsychotic agent thioridazine (THIO). The mechanisms underlying these effects are unknown. The objectives of this study were 1) to characterize the effects of THIO on cardiac repolarization and 2) to determine whether lengthening of the Q-T interval could be explained by blocking major K+-repolarizing currents. Isolated, buffer-perfused guinea pig hearts (n = 32) were stimulated at various pacing cycle lengths (150-250 ms) and exposed to THIO at concentrations ranging from 300 nM to 3 microM. THIO increased monophasic action potential duration at 90% repolarization (MAPD90) in a concentration-dependent manner from 14.9 +/- 1.8 at 300 nM to 37.1 +/- 3.2 ms at 3 microM. Increase in MAPD90 was also reverse frequency-dependent; THIO (300 nM) increased MAPD90 by 14.9 +/- 1.8 ms at a pacing cycle length of 250 ms, but by only 7.7 +/- 1.2 ms at a pacing cycle length of 150 ms. Patch-clamp experiments demonstrated that THIO decreases the time-dependent outward K+ current elicited by short depolarizations (250 ms; IK250) in a concentration-dependent manner. Estimated IC50 for IK250, which mostly underlies IKr, was 1.25 microM. Time-dependent outward K+ current elicited in tsA201 cells expressing high levels of HERG protein was also decreased approximately 50% by 1.25 microM THIO. On the other hand, THIO was less potent (IC50 of 14 microM) to decrease time-dependent K+ current elicited by long pulses (5000 ms; IK5000). Under the latter conditions, IK5000 corresponds mainly to IKs. Thus, these results demonstrate block of K+ currents and lengthening of cardiac repolarization by THIO in a concentration-dependent manner. This may provide an explanation of Q-T prolongation observed in some patients treated with THIO.  (+info)

Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol. (2/2962)

Epidemiological studies suggest that there is a beneficial effect of moderate ethanol consumption on the incidence of cardiovascular disease. Ethanol is metabolized to acetaldehyde, a two-carbon carbonyl compound that can react with nucleophiles to form covalent addition products. We have identified a biochemical modification produced by the reaction of acetaldehyde with protein-bound Amadori products. Amadori products typically arise from the nonenzymatic addition of reducing sugars (such as glucose) to protein amino groups and are the precursors to irreversibly bound, crosslinking moieties called advanced glycation endproducts, or AGEs. AGEs accumulate over time on plasma lipoproteins and vascular wall components and play an important role in the development of diabetes- and age-related cardiovascular disease. The attachment of acetaldehyde to a model Amadori product produces a chemically stabilized complex that cannot rearrange and progress to AGE formation. We tested the role of this reaction in preventing AGE formation in vivo by administering ethanol to diabetic rats, which normally exhibit increased AGE formation and high circulating levels of the hemoglobin Amadori product, HbA1c, and the hemoglobin AGE product, Hb-AGE. In this model study, diabetic rats fed an ethanol diet for 4 weeks showed a 52% decrease in Hb-AGE when compared with diabetic controls (P < 0.001). Circulating levels of HbA1c were unaffected by ethanol, pointing to the specificity of the acetaldehyde reaction for the post-Amadori, advanced glycation process. These data suggest a possible mechanism for the so-called "French paradox," (the cardioprotection conferred by moderate ethanol ingestion) and may offer new strategies for inhibiting advanced glycation.  (+info)

Effects of MCI-154 on calcium sensitivity of contractile system and calcium release from sarcoplasmic reticulum in saponin-skinned rat myocardium. (3/2962)

AIM: To explore the possible mechanisms underlying the positive inotropic effect of MCI-154. METHODS: Skinned fibers with disrupted or preserved sarcoplasmic reticulum (SR) were prepared by saponin 500 or 50 mg.L-1. The tension-pCa relationship and pCa50 of saponin (500 mg.L-1)-skinned fibers were taken as the indices of Ca2+ sensitivity of contractile proteins. The amplitude of caffeine-induced contracture was an index of Ca2+ release from SR in saponin (50 mg.L-1)-skinned fibers. RESULTS: 1) MCI-154 (0.1 mmol.L-1) showed a Ca2+ sensitizing effect on contractile proteins. The pCa50 was increased to 5.84 (5.54-6.14) compared with control value 5.54 (5.30-5.79) (P < 0.01, n = 8). Hill coefficient n was decreased by 0.29 (P < 0.01, n = 8); 2) No contracture was produced by MCI-154 in preparations with preserved SR. Caffeine-induced contracture before and after MCI-154 treatment were not changed (P > 0.05, n = 4). CONCLUSION: MCI-154 directly enhances the Ca2+ sensitivity of contractile protein but has little effect on Ca2+ release from SR in rat skinned cardiac fibers.  (+info)

Study on propionyl-L-carnitine in chronic heart failure. (4/2962)

AIMS: In patients with chronic heart failure, fatigue is independent of haemodynamic and neuroendocrine changes and possibly may be due to impaired muscle metabolism. Propionyl-L-carnitine, a carnitine derivative, was shown in previous studies to improve muscle metabolism. The objective of this study was to evaluate the effect of propionyl-L-carnitine on exercise capacity in mild moderate chronic heart failure patients, treated with ACE inhibitors and diuretics. METHODS AND RESULTS: This was a phase III, double-blind, randomized, parallel, multicentre study. The primary objective was the evaluation of the effect of propionyl-L-carnitine vs placebo on maximum exercise duration using a bicycle exercise test. The primary analysis performed in the intention-to-treat population (271 and 266 patients in propionyl-L-carnitine and placebo), showed no statistically significant difference between treatments. A difference of 15 s in favour of propionyl-L-carnitine was observed in the completer/complier population (P=0.092). An a priori specified subgroup analysis on patients stratified by baseline maximum exercise duration showed a trend of improvement in propionyl-L-carnitine patients with shorter maximum exercise duration. A non a priori specified analysis in patients stratified by ejection fraction (< or = 30% vs 30-40%), showed a statistically significant difference in maximum exercise duration in favour of propionyl-L-carnitine in those patients with a higher ejection fraction (40 s, P<0.01). There were no safety issues. CONCLUSION: The study fails to meet the primary objective, but confirms the good safety profile of propionyl-L-carnitine. An exploratory non-prespecified analysis suggests that propionyl-L-carnitine improves exercise capacity in patients with preserved cardiac function. This hypothesis needs to be confirmed by a specific tailored study.  (+info)

Recovery of contractility of viable myocardium during inotropic stimulation is not dependent on an increase of myocardial blood flow in the absence of collateral filling. (5/2962)

OBJECTIVES: The purpose of this study was to determine whether contractile recovery induced by dobutamine in dysfunctioning viable myocardium supplied by nearly occluded vessels is related to an increase in blood flow in the absence of collaterals. BACKGROUND: Dobutamine is used to improve contractility in ventricular dysfunction during acute myocardial infarction. However, it is unclear whether a significant increase in regional blood flow may be involved in dobutamine effect. METHODS: Twenty patients with 5- to 10-day old anterior infarction and > or =90% left anterior descending coronary artery stenosis underwent 99mTc-Sestamibi tomography (to assess myocardial perfusion) at rest and during low dose (5 to 10 microg/kg/min) dobutamine echocardiography. Rest echocardiography and scintigraphy were repeated >1 month after revascularization. Nine patients had collaterals to the infarcted territory (group A), and 11 did not (group B). RESULTS: Baseline wall motion score was similar in both groups (score 15.9+/-1.3 vs. 17.4+/-2.0, p = NS), whereas significant changes at dobutamine and postrevascularization studies were detected (F[2,30] = 409.79, p < 0.0001). Wall motion score improved significantly (p < 0.001) in group A both at dobutamine (-5.3+/-2.2) and at postrevascularization study (-5.5+/-1.9), as well as in group B (-3.9+/-2.8 and -4.5+/-2.4, respectively). Baseline 99mTc-Sestamibi uptake was similar in both groups (62.9+/-9.7% vs. 60.3+/-10.4%, p = NS), whereas at dobutamine and postrevascularization studies a significant change (F[2,30] = 65.17, p < 0.0001) and interaction between the two groups (F[2,30] = 33.14, p < 0.0001) were present. Tracer uptake increased significantly in group A both at dobutamine (+ 10.9+/-7.9%, p < 0.001) and at postrevascularization study (12.1+/-8.7%, p < 0.001). Conversely, group B patients showed no change in tracer uptake after dobutamine test (-0.4+/-5.8, p = NS), but only after revascularization (+8.8+/-7.2%, p < 0.001). CONCLUSIONS: The increase in contractility induced by low dose dobutamine infusion in dysfunctional viable myocardium supplied by nearly occluded vessels occurs even in the absence of a significant increase in blood flow.  (+info)

Prognostic value of dobutamine stress echocardiography in predicting cardiac events in patients with known or suspected coronary artery disease. (6/2962)

OBJECTIVES: The study sought to determine the utility of dobutamine stress echocardiography (DSE) in predicting cardiac events in the year after testing. BACKGROUND: Increasingly, DSE has been applied to risk stratification of patients. METHODS: Medical records of 1,183 consecutive patients who underwent DSE were reviewed. The cardiac events that occurred during the 12 months after DSE were tabulated: myocardial infarction (MI), cardiac death, percutaneous transluminal coronary angioplasty (PTCA), and coronary artery bypass surgery (CABG). Patient exclusions included organ transplant receipt or evaluation, recent PTCA, noncardiac death, and lack of follow-up. A positive stress echocardiogram (SE) was defined as new or worsened wall-motion abnormalities (WMAs) consistent with ischemia during DSE. Classification and regression tree (CART) analysis identified variables that best predicted future cardiac events. RESULTS: The average age was 68+/-12 years, with 338 women and 220 men. The overall cardiac event rate was 34% if SE was positive, and 10% if it was negative. The event rates for MI and death were 10% and 8%, respectively, if SE was positive, and 3% and 3%, respectively, if SE was negative. If an ischemic electrocardiogram (ECG) and a positive SE were present, the overall event rate was 42%, versus a 7% rate when ECG and SE were negative for ischemia. Rest WMA was the most useful variable in predicting future cardiac events using CART: 25% of patients with and 6% without a rest WMA had an event. Other important variables were a dobutamine EF <52.5%, a positive SE, an ischemic ECG response, history of hypertension and age. CONCLUSIONS: A positive SE provides useful prognostic information that is enhanced by also considering rest-wall motion, stress ECG response, and dobutamine EF.  (+info)

Integrated evaluation of relation between coronary lesion features and stress echocardiography results: the importance of coronary lesion morphology. (7/2962)

OBJECTIVES: The aim of this study was to analyze, in the same group of patients, the relationship between multiple variables of coronary lesion and results of exercise, dobutamine and dipyridamole stress echocardiography tests. BACKGROUND: Integrated evaluation of the relation between stress echocardiography results and angiographic variables should include not only the assessment of stenosis severity but also evaluation of other quantitative and qualitative features of coronary stenosis. METHODS: Study population consisted of 168 (138 male, 30 female, mean age 51+/-9 years) patients, on whom exercise (Bruce treadmill protocol), dobutamine (up to 40 mcg/kg/min) and dipyridamole (0.84 mg/kg over 10 min) stress echocardiography tests were performed. Stress echocardiography test was considered positive for myocardial ischemia when a new wall motion abnormality was observed. One-vessel coronary stenosis ranging from mild stenosis to complete obstruction of the vessel was present in 153 patients, and 15 patients had normal coronary arteries. The observed angiographic variables included particular coronary vessel, stenosis location, the presence of collaterals, plaque morphology according to Ambrose classification, percent diameter stenosis and obstruction diameter as assessed by quantitative coronary arteriography. RESULTS: Covariates significantly associated with the results of physical and pharmacological stress tests included for all three stress modalities presence of collateral circulation, percent diameter stenosis and obstruction diameter, as well as lesion morphology (p < 0.05 for all, except collaterals for dobutamine stress test, p = 0.06). By stepwise multiple logistic regression analysis, the strongest predictor of the outcome of exercise echocardiography test was only percent diameter stenosis (p = 0.0002). However, both dobutamine and particularly dipyridamole stress echocardiography results were associated not only with stenosis severity - percent diameter stenosis (dobutamine, p = 0.04; dipyridamole, p = 0.003) - but also, and even more strongly, with lesion morphology (dobutamine, p = 0.006; dipyridamole, p = 0.0009). As all of stress echocardiography results were significantly associated with percent diameter stenosis, the best angiographic cutoff in relation to the results of stress echocardiography test was: exercise, 54%; dobutamine, 58% and dipyridamole, 60% (p < 0.05 vs. exercise). CONCLUSIONS: Integrated evaluation of angiographic variables have shown that the results of dobutamine and dipyridamole stress echocardiography are not only influenced by stenosis severity but also, and even more importantly, by plaque morphology. The results of exercise stress echocardiography, although separately influenced by plaque morphology, are predominantly influenced by stenosis severity, due to a stronger exercise capacity in provoking myocardial ischemia in milder forms of coronary stenosis.  (+info)

Functional status and quality of life in patients with heart failure undergoing coronary bypass surgery after assessment of myocardial viability. (8/2962)

OBJECTIVES: The aim of this study was to evaluate whether preoperative clinical and test data could be used to predict the effects of myocardial revascularization on functional status and quality of life in patients with heart failure and ischemic LV dysfunction. BACKGROUND: Revascularization of viable myocardial segments has been shown to improve regional and global LV function. The effects of revascularization on exercise capacity and quality of life (QOL) are not well defined. METHODS: Sixty three patients (51 men, age 66+/-9 years) with moderate or worse LV dysfunction (LVEF 0.28+/-0.07) and symptomatic heart failure were studied before and after coronary artery bypass surgery. All patients underwent preoperative positron emission tomography (PET) using FDG and Rb-82 before and after dipyridamole stress; the extent of viable myocardium by PET was defined by the number of segments with metabolism-perfusion mismatch or ischemia. Dobutamine echocardiography (DbE) was performed in 47 patients; viability was defined by augmentation at low dose or the development of new or worsening wall motion abnormalities. Functional class, exercise testing and a QOL score (Nottingham Health Profile) were obtained at baseline and follow-up. RESULTS: Patients had wall motion abnormalities in 83+/-18% of LV segments. A mismatch pattern was identified in 12+/-15% of LV segments, and PET evidence of viability was detected in 30+/-21% of the LV. Viability was reported in 43+/-18% of the LV by DbE. The difference between pre- and postoperative exercise capacity ranged from a reduction of 2.8 to an augmentation of 5.2 METS. The degree of improvement of exercise capacity correlated with the extent of viability by PET (r = 0.54, p = 0.0001) but not the extent of viable myocardium by DbE (r = 0.02, p = 0.92). The area under the ROC curve for PET (0.76) exceeded that for DbE (0.66). In a multiple linear regression, the extent of viability by PET and nitrate use were the only independent predictors of improvement of exercise capacity (model r = 0.63, p = 0.0001). Change in Functional Class correlated weakly with the change in exercise capacity (r = 0.25), extent of viable myocardium by PET (r = 0.23) and extent of viability by DbE (r = 0.31). Four components of the quality of life score (energy, pain, emotion and mobility status) significantly improved over follow-up, but no correlations could be identified between quality of life scores and the results of preoperative testing or changes in exercise capacity. CONCLUSIONS: In patients with LV dysfunction, improvement of exercise capacity correlates with the extent of viable myocardium. Quality of life improves in most patients undergoing revascularization. However, its measurement by this index does not correlate with changes in other parameters nor is it readily predictable.  (+info)

Patients with diabetes and ischemic heart disease (IHD) are at high risk for adverse cardiac outcomes. Clinical practice guidelines recommend multiple cardioprotective medications to reduce recurrent events. We evaluated the association between cardioprotective medication adherence and mortality among patients with diabetes and IHD. In a retrospective cohort study of 3,998 patients with diabetes and IHD, we evaluated use of ACE inhibitors or angiotensin receptor blockers, β-blockers, and statin medications. Receipt of cardioprotective medications was based on filled prescriptions. Medication adherence was calculated as the proportion of days covered (PDC) for filled prescriptions. The primary outcome of interest was all-cause mortality. The majority of patients (92.8%) received at least 1 cardioprotective medication. Patients receiving any medications had lower unadjusted mortality rates compared to patients not receiving any medications (7.9% vs. 11.5%; p = 0.03). In multivariable analysis, receipt of
Doxorubicin (DOX) is a potent and widely used anthracycline antibiotic for the treatment of several malignancies. Unfortunately, the clinical utility of DOX is often restricted due to the elicitation of organ toxicity. Particularly, the increased risk for the development of dilated cardiomyopathy by DOX among the cancer survivors warrants major attention from the physicians as well as researchers to develop adjuvant agents to neutralize the noxious effects of DOX on the healthy myocardium. Despite these pitfalls, the use of traditional cytotoxic drugs continues to be the mainstay treatment for several types of cancer. Recently, phytochemicals have gained attention for their anticancer, chemopreventive, and cardioprotective activities. The ideal cardioprotective agents should not compromise the clinical efficacy of DOX and should be devoid of cumulative or irreversible toxicity on the naïve tissues. Furthermore, adjuvants possessing synergistic anticancer activity and quelling of chemoresistance
Leh, May 09: As per the media bulletin released by the Directorate of Health Services UT Ladakh, a total of 156 new positive sample reports of Covid-19 were received yesterday. Out of the total positive reports, 140 reports were received by CMO Leh and 16 positive sample reports were received by CMO Kargil. With the […]
The ministry of health is reporting 8 deaths and 318 new positive Covid 19 cases in its 4:00pm clinical update today, bringing the total numbers of deaths to 1159 and total active positive cases to 6015. ...
The ViiV Healthcare Positive Action strategy 2020- 2030 was launched in December 2019. Click here to download our high-level strategy.. The strategy works towards achieving healthy communities in a world free of AIDS and supports ViiVs mission of leaving no person living with HIV behind.. Positive Action has developed a logic framework which demonstrates how we will achieve our overall strategy.. Information for grantees who have received funding under the previous programmes (PACF, PAGW, PA, PA MSM&T and PA Europe can be found here).. The new Positive Action strategy has three categories of funding. Challenges, Community Strategic Initiatives and Breakthrough.. For any questions relating to the Positive Action strategy 2020 - 2030 or the funding rounds please send an email to [email protected] Innovator Grants. Positive Action invites applications to the Round 1 funding for Innovator Grants focusing on HIV-related Stigma under two themes:. ...
Lisoprotérénol est un relativement sélectif bêta2-adrénergiques bronchodilatateur. Lisoprotérénol est indiqué pour le soulagement des bronchospasmes associés aux maladies pulmonaires obstructives chroniques. Le pharmacologiques effets des bêta-adrénergique médicaments, y compris lisoprotérénol, sont au moins en partie attribuable à la stimulation par le biais des récepteurs bêta-adrénergiques adénylcyclase intracellulaire, lenzyme qui catalyse la conversion de ladénosine triphosphate (ATP) pour cyclique-3 , 5-adénosine monophosphate (AMP-c). Augmentation de c-AMP niveaux sont associées à la relaxation des muscles lisses bronchiques et une inhibition de la libération des médiateurs de lhypersensibilité immédiate à partir des cellules, en particulier par les mastocytes ...
Arjunin is supportive therapy in patients with risk of heart problems. Arjuna the main ingredient of Arjunin is proven to haveanti-anginal, hypolipidaemic and anti-oxidant action. Punarnava helps to manage lipid levels in the body, Jatamamsi reduces the oxidation of lipids and helps to reduce stress & anxiety.draksha & Ara are cardio-protective and anti-oxidants. ...
Effective September 21, 2021, the website and COVID update line, 727-302-3818, will only be updated when there is a change in our status. CURRENT STATUS Menorah Manor There are no new positive cases Current Status: One positive staff at the nursing center Two positive residents at the nursing center Current Action being taken: The staff has been removed from the schedule until
Learn Beta-1 Agonists - Inotropes - Pharmacology - Picmonic for Medicine faster and easier with Picmonics unforgettable images and stories! Picmonic is research proven to increase your memory retention and test scores. Start learning today for free!
Our retrospective analysis of patients from the DIG trial demonstrates that the clinical effects of digoxin in women, as in men, are significantly influenced by serum concentration, with divergent outcomes relative to placebo at low versus high concentrations. Specifically, there was no evidence that digoxin increased mortality in women at low serum concentrations by any of our analytical approaches. The point estimate for the relative risk of death on digoxin versus placebo was below unity for women at detectable serum concentrations ,1 ng/ml. In addition, digoxin substantially reduced the risk of hospital stay for worsening HF and the risk of the combined end point of mortality and HF hospital stay in women at low SDCs (0.5 to 0.9 ng/ml). In contrast, the risk for mortality was greater than placebo when serum concentrations were ≥1.2 ng/ml, and there was no reduction in the risk of the combined end point at higher serum concentrations. Our study cannot define the mechanisms responsible for ...
Our retrospective analysis of patients from the DIG trial demonstrates that the clinical effects of digoxin in women, as in men, are significantly influenced by serum concentration, with divergent outcomes relative to placebo at low versus high concentrations. Specifically, there was no evidence that digoxin increased mortality in women at low serum concentrations by any of our analytical approaches. The point estimate for the relative risk of death on digoxin versus placebo was below unity for women at detectable serum concentrations ,1 ng/ml. In addition, digoxin substantially reduced the risk of hospital stay for worsening HF and the risk of the combined end point of mortality and HF hospital stay in women at low SDCs (0.5 to 0.9 ng/ml). In contrast, the risk for mortality was greater than placebo when serum concentrations were ≥1.2 ng/ml, and there was no reduction in the risk of the combined end point at higher serum concentrations. Our study cannot define the mechanisms responsible for ...
Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Background Randomized clinical trials showed the benefit of pharmacological and revascularization treatments in secondary prevention of myocardial infarction (MI), in selected population with highly controlled interventions. The objective of this study is to measure these treatments impact on the cardiovascular (CV) mortality rate among patients receiving usual care in the province of Quebec. Methods The study population consisted of a naturalistic cohort of all patients ? 65 years old living in the Quebec province, who survived a MI (ICD-9: 410) in 1998. The studied dependant variable was time to death from a CV disease. Independent variables were revascularization procedure and cardioprotective drugs. Death from a non CV disease was also studied for comparison. Revascularization procedure was defined as percutaneous transluminal coronary angioplasty (PTCA) or coronary artery bypass graft (CABG). The exposure to cardioprotective drugs was defined as the number of cardioprotective drug classes
TY - JOUR. T1 - Avoiding erroneous serum digoxin concentrations. AU - Murphy, J. E.. AU - Ward, E. S.. AU - Job, M. L.. PY - 1985/12/1. Y1 - 1985/12/1. UR - http://www.scopus.com/inward/record.url?scp=0022180028&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0022180028&partnerID=8YFLogxK. M3 - Letter. C2 - 4073054. AN - SCOPUS:0022180028. VL - 42. SP - 2418. EP - 2420. JO - American Journal of Health-System Pharmacy. JF - American Journal of Health-System Pharmacy. SN - 1079-2082. IS - 11. ER - ...
Albone KS, Gaskin P, MacMillan J, Sponsel VM. Identification and localization of gibberlins in maturing seed of cucurbit Sechium edule, and a comparison between this cucurbit and the legume Phaseolus coccineus. Planta Springer-verla. 1984; 162: 560-65. Farvin KH, Anandan R, Kumar SH, Shiny KS, Mathew S, Sankar TV, Nair PG. Cardioprotective effect of Squalene on lipid profile in isoprenaline-induced myocardial infarction in rats. J Med Food. 2006; 9: 531-36. Firdous SM, Sravanthi K, Debnath R, Neraja K. Protective effect of ethanolic extract and its ethylacetate and n-butanol fractions of Sechium edule fruits against carbon tetrachloride induced hepatic injury in rats. Int J Pharm Pharm Sci. 2012; 4: 354-59. Firdous SM, Neraja K, Debnath R, Singha D, Sravanthi K. Evaluation of antiulcer activity of ethanolic extract of Sechium edule fruits in experimental rats. Int J Pharm Pharm Sci. 2012; 4: 374-77. Gordon EA, Guppy LJ, Nelson M. The antihypertensive effects of the Jamaican Cho-Cho (Sechium ...
Cardioprotective medication use and risk factor control among US adults with unrecognized myocardial infarction: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study Emily B Levitan,1 Christopher Gamboa,1 Monika M Safford,2 Dana V Rizk,3 Todd M Brown,4 Elsayed Z Soliman,5 Paul Muntner11Department of Epidemiology, 2Division of Preventive Medicine, 3Division of Nephrology, 4Division of Cardiology, University of Alabama at Birmingham, Birmingham, AL, USA; 5Epidemiological Cardiology Research Center, Wake Forest University School of Medicine, Winston Salem, NC, USABackground: Individuals with unrecognized myocardial infarction (UMI) have similar risks for cardiovascular events and mortality as those with recognized myocardial infarction (RMI). The prevalence of cardioprotective medication use and blood pressure and low-density lipoprotein cholesterol control among individuals with UMI is unknown.Methods: Participants from the REasons for Geographic And Racial Differences in Stroke
Objective We investigated the impact of cardioprotective drugs on ST-elevation, arrhythmias and infarct size in a rat model of repetitive coronary artery occlusion. alone and RO plus nitroglycerin were associated with significantly lower maximal ST-elevation and percentage of infarcted myocardium (SHAM 0.12 mV, 741713-40-6 ROP 0.06 mV (p=0.004), NTG 0.05 mV (p=0.005); SHAM 16.2%, ROP 6.6% (p=0.008), NTG 5.9% (p=0.006). Compared with RO alone, RO plus RAN was accompanied by increased ST-elevation (0.13 mV, p=0.018) and RO plusVER or CAN by more infarcted myocardium (14.2%, p=0.004% and 15.5%, p=0.003, respectively). Rats treated with VER, RAN or CAN tended to severe arrhythmias more frequently than those of the control groups. Conclusions RO led to an increased myocardial resistance against ischaemia 741713-40-6 and reperfusion injury. Concomitant administration of nitroglycerin didnt affect the efficiency of RO. Cardiovascular receptor or route blockers decreased the efficacy of RO. discovered ...
In some patients, orally administered digoxin is converted to inactive reduction products (e.g., dihydrodigoxin) by colonic bacteria in the gut. Data suggest that one in ten patients treated with digoxin tablets will degrade 40% or more of the ingested dose. As a result, certain antibiotics may increase the absorption of digoxin in such patients. Although inactivation of these bacteria by antibiotics is rapid, the serum digoxin concentration will rise at a rate consistent with the elimination half-life of digoxin. The magnitude of rise in serum digoxin concentration relates to the extent of bacterial inactivation, and may be as much as two-fold in some cases.. Distribution: Following drug administration, a 6- to 8-hour tissue distribution phase is observed. This is followed by a much more gradual decline in the serum concentration of the drug, which is dependent on the elimination of digoxin from the body. The peak height and slope of the early portion (absorption/distribution phases) of the ...
New positive results from an interim analysis of the Phase 2 open-label extension (OLE) study of fitusiran, in development for the treatment of hemophilia A or B, with or without inhibitors, were presented at the World Federation of Hemophilia (WFH) Virtual Summit, held June 14-19, 2020.. Read the press release. View the presentation. In the data presented at WFH, monthly subcutaneous dosing with fitusiran in patients (N = 34) with moderate or severe hemophilia A and B, with and without inhibitors, demonstrated a durable therapeutic effect, including sustained lowering of antithrombin, increased thrombin generation, and low overall annualized bleed rate (median 0.84) in the median observation period of 36 months.. Long-term exposure to fitusiran in the Phase 2 OLE study reveals a safety profile that is supportive of continued evaluation of fitusiran in the ongoing Phase 3 ATLAS program.. Sanofi Genzyme is leading and funding the global development of fitusiran and will commercialize fitusiran, ...
Hospitalizations for acute heart failure are associated with high mortality and readmission rates. Ten to 20% of the patients have signs of low cardiac output and fluid overload. The administration of inotropic agents to correct these hemodynamic abnormalities may be indicated in these patients. However, the risk to benefit ratio of inotropic agents is high and an increase of untoward effects and mortality has been suggested by many retrospective analyses and meta-analyses. Limitations of inotropic therapy seem mainly related to their mechanisms of action based, in the case of the traditional agents, on an increase in intracellular cyclic AMP and calcium concentrations. Concomitant peripheral vasodilation, such as in the case of the novel agent levosimendan is another important limitation, above when patients are hypotensive and/or treated with vasodilators and high doses of diuretics. Myosin activators, histaroxime, sarcoplasmic reticulum ATPase activators and metabolic agents seem promising as active
TY - JOUR. T1 - The Role of Humoral Factors in Producing the Cardioprotective Effect of Remote Ischemic Preconditioning. AU - Prokudina, E. S.. AU - Maslov, L. N.. AU - Jaggi, A. S.. AU - Pismennyi, D. S.. AU - Voronkov, N. S.. AU - Nesterov, E. A.. PY - 2019/3/15. Y1 - 2019/3/15. N2 - The humoral pathway mediating the cardioprotective effect of remote ischemic preconditioning has been demonstrated in various models: ischemia-reperfusion of the fore- and hindlimbs and liver and occlusion-reperfusion of the mesenteric and renal arteries. This review assesses humoral components in the formation and realization of the cardioprotective actions of remote ischemic preconditioning of the heart. Endogenous agonists of opioid receptors, arachidonic acid derivatives (prostanoids), agonists of cannabinoid and vanilloid receptors, calcitonin gene-related peptide, leukotrienes, and microRNA are all regarded as humoral components. Adenosine, which also has a role in mediating the cardioprotective effects of ...
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SF 349, an analogue of milrinone, was being developed at a number of universities in Italy as a cardiotonic agent. It was in preclinical investigation and
Cardioprotective Effect of Parawata Shakrit(Fecal matter of Pigeon) in Isoprenaline induced Myocardial Ischaemia in Rabbits. Cardioprotective Effect of Parawata Shakrit Click Above Link To Read full content
62.5 mcg = 0.0625 mg Example: Based on Table 5,. (0.25 mg) daily of LANOXIN Tablets, usually taken after the morning meal. If no.LANOXIN*0,0625MG 30 CPR: AZIENDA. 0,75-1,5 mg seguiti da 0,25 mg a intervalli di 6 ore fino a ottenere leffetto terapeutico ottimale o,.Mihai Gheorghiade, MD. Valsartan 80 mg bid (n = 4885) Acute MI (0.5 - 10 days). 0.5 0.8 1.0 1.2 1.4 1.6 1.8 2.0 Serum Digoxin Concentration.REAGENTI ORGANICI Descrizione (-). Digoxin DILUENTE PER ANTICORPI. R-PE 0,5 mg REPORTER LYSIS 5X BUFFER RPMI RPMI 1640 10x500 ml.LANOXIN*30CPR 0,0625MG. 2,01. una posologia di 0,0625 mg algiorno (o meno) puo essere sufficiente. Al contrario alcuni pazientipossono richiedere una dose maggiore.. 180 tablet x 0.25mg. I end up just to introduce only affords of the counting England Wales in. The dining room lanoxin you how much I worse or at least the state.lanoxin dosages. In the journal Nature Genetics, researchers from the UK and Germany describe how they found variants in the gene ASAP1 on ...
I am trying to verify quality of some PLCAR and LCLT For the PLCAR Jarrow Formulas Glycine Propionyl-L-Carnitine HCl 758 Milligrams * Propionyl-L-Carni
Karnataka has reported 8852 new cases of Covid19 and 106 fatalities in the last 24 hours. 7101 patients have been discharged today . Out of 8852, 2821 cases are from Bengaluru. Till date, 335928 positive cases have been confirmed in the state, it includes 242229 discharges & 5589 deaths+ 19 deaths due to non covid cause. Among 88091 active cases,730 are admitted in ICU.. ...
SNY MLB Insider Andy Martino reacts to the news of Yankees Gleyber Torres testing positive for COVID-19 despite being fully vaccinated. Martino says the CDC is now investigating what might have happened within the Yankees organization now that eight members of the organization have tested positive despite being vaccinated.
AF patients starting digoxin treatment showed increased mortality, especially in the first 6 months, irrespective of the coexistence of HF, and digoxin concentrations >1.2 ng/ml should be avoided.
Mackerel is an oily fish containing omega 3 fatty acids, which are thought to be cardio-protective and also improve brain function. We are recommended to eat oily fish once per week so this recipe is an economical (and delicious) way to help you meet this target. ...
Curcumin is a compound with powerful antioxidant, anti-inflammatory, anti-pain, neuroprotective, and cardioprotective properties.
TY - CONF. T1 - Cardioprotective effects of selected novel amides. AU - Maddock, Helen. PY - 2004/4/4. Y1 - 2004/4/4. M3 - Poster. T2 - British Society for Cardiovascular Research Meeting. Y2 - 4 April 2004 through 4 April 2004. ER - ...
Learn Inotropes - Pharmacology - Cardiovascular System - NCLEX® - Picmonic for Nursing RN faster and easier with Picmonics unforgettable videos, stories, and quizzes! Picmonic is research proven to increase your memory retention and test scores. Start learning today for free!
DOBUTamine was found in Medicine Central. Medicine Central™ is a quick-consult mobile and web resource that includes diagnosis, treatment, medications, and follow-up information on over 700 diseases and disorders, providing fast answers-anytime, anywhere.
Welcome to Laboratorio LIBRA, a dynamic Uruguayan company whith a responsible and committed relationship with health professionals and users.. ...
AbstractAcquired demyelinating syndromes include acute disseminated encephalomyelitis, transverse myelitis and may progress to multiple sclerosis (MS). Acute disseminated encephalomyelitis is characterized by impairment of level of consciousness and multifocal neurological deficits and transverse my
TY - JOUR. T1 - The effect of extract from Rhodiola rosea on the level of inducible HSP-70 in the myocardium during stress. AU - Lishmanov, Yu B.. AU - Krylatov, A. V.. AU - Maslov, L. N.. AU - Naryzhnaya, N. V.. AU - Zamotrinskii, A. V.. PY - 1996/3. Y1 - 1996/3. N2 - It is demonstrated that the cardioprotective activity of extract from Rhodiola rosea in stress reaches the maximum 5 days after the first dose. Heat shock proteins appear in the myocardium 3 days after an 8-day administration of the extract. It is believed that these proteins are not an important factor in the cardioprotective effect of the extract.. AB - It is demonstrated that the cardioprotective activity of extract from Rhodiola rosea in stress reaches the maximum 5 days after the first dose. Heat shock proteins appear in the myocardium 3 days after an 8-day administration of the extract. It is believed that these proteins are not an important factor in the cardioprotective effect of the extract.. KW - Adaptation. KW - Heat ...
TY - JOUR. T1 - Impact of a novel cardioprotective agent on the ischaemia-reperfusion- induced Akt kinase activation. AU - Toth, Ambrus. AU - Kovacs, Krisztina. AU - Deres, Peter. AU - Halmosi, Robert. AU - Czopf, Laszlo. AU - Hanto, Katalin. AU - Kalai, Tamas. AU - Hideg, Kalman. AU - Sumegi, Balazs. AU - Toth, Kalman. PY - 2003/12/1. Y1 - 2003/12/1. N2 - Cardioprotective effect of a free radical-scavenging compound (HO-3073) was examined during ischaemia-reperfusion (IR) in isolated heart perfusion system and its influence on the pro-survival Akt signalling pathway was addressed. Rat hearts were perfused according to the Langendorff method and subjected to a global 25-min ischaemia and 15, 45 and 90-min reperfusion either untreated or treated with HO-3073 (2, 5 and 10μM) and/or wortmannin (100nM, inhibitor of phosphatidylinositol-3-kinase). HO-3073 facilitated the recovery of myocardial energy metabolism as assessed by 31P NMR spectroscopy (creatine phosphate recovery in reperfusion was ...
Our data clearly demonstrate significant cardioprotective activities of the novel small molecule C1 inhibitor (C1s-INH-248) in myocardial ischemia and reperfusion. The cardioprotection exerted by C1s-INH-248 was characterized by a reduction of necrosis and decreased serum CK activity compared with rabbits given the vehicle only. The cardioprotective effect of C1s-INH-248 was dose dependent when administrated as a 0.1-1 mg/kg body weight bolus injection. Even compared with the treatment with the C1 esterase inhibitor (C1-INH) C1s-INH-248 demonstrated superior potency. The protection of C1s-INH-248 also resulted in inhibition of PMN accumulation in the reperfused myocardium. Further, the protective effect could be attributed to decreased deposition of C5b-9 on ischemic reperfused myocardium or vascular endothelial cells. To our knowledge, this is the first study demonstrating cardioprotection with a highly specific synthetic C1 inhibitor following myocardial ischemia and reperfusion.. To date, ...
[Coronary Spasm after Administration of Propranolol during Dobutamine Stress Echocardiography]. - Lucía Alvarez, José Zamorano, Luis Mataix, Carlos Almeria, Raúl Moreno, José Luis Rodrigo
Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion.We have analyzed global changes in gene expression in cardiac myocytes after urocortin treatment using gene chip technology. We report that urocortin specifically induces enhanced expression of the Kir 6.1 cardiac potassium channel subunit. On the basis of this finding, we showed that the cardioprotective effect of urocortin both in isolated cardiac cells and in the intact heart is specifically blocked by both generalized and mitochondrial-specific K(ATP) channel blockers, whereas the cardioprotective effect of cardiotrophin-1 is unaffected. Conversely, inhibiting the Kir 6.1 channel subunit greatly enhances cardiac cell death after ischemia.This is, to our knowledge, the first report of the altered expression of a K(ATP) channel subunit induced by a cardioprotective agent and demonstrates that K
TY - JOUR. T1 - Effects of propionyl-L-carnitine in chronically hypoperfused (hibernating) myocardium. AU - Bolukoglu, H.. AU - Eggleston, A. M.. AU - Subramanian, R.. AU - Nellis, S. H.. AU - Liedtke, A. J.. N1 - Copyright: Copyright 2004 Elsevier B.V., All rights reserved.. PY - 1991. Y1 - 1991. N2 - The purpose of this report was to test the effects of systemic treatment with propionyl-L-carnitine in a new model of chronically hypoperfused (hibernating) myocardium. Adolescent swine were instrumented to undergo a period of mild partial coronary constriction for 1 week (50% reduction of the maximum phasic flow velocity in the anterior descending coronary artery). This reduced regional mechanical function by 56%. The system satisfied criteria defining hibernating myocardium, in that the chronic hypoperfusion did not produce massive tissue necrosis and that the reduction in regional contraction remained responsive to inotropic stimulation. Treatment with 50 mg/kg propionyl-L-carnitine by ...
Phenylephrine is a powerful vasoconstrictor. It is used as a mydriatic, nasal decongestant, and cardiotonic agent. Phenylephrine is a postsynaptic alpha-receptor stimulant with little effect on the beta receptors of the heart. Parenteral administration of Phenylephrine causes a rise in systolic and diastolic pressures, cardiac output is slightly decreased and peripheral resistance is considerably increased, most vascular beds are constricted; renal, splanchnic, cutaneous, and limb blood flows are reduced but coronary blood flow is increased. Pulmonary vessels are constricted, and pulmonary arterial pressure is raised. This alpha receptor sympathetic agonist is also used locally because its vasoconstrictor and mydriatic action ...
The age or gender of the person being tested, health history, the method used for the test, and many other factors may affect when and how often a lab test is required. The therapeutic range is 0.8 to 2.0ng/mL for those being treated for heart failure and levels ,4.0 ng/mL may be potentially life-threatening. This range for digoxin has been established over time. Once the dosage level is determined, digoxin levels are monitored routinely, at a frequency determined by the doctor, to verify correct dosage and if any changes occur in drug source, dosage, or other medications taken at the same time. Recent studies may help to improve patient selection for digoxin therapy, since Digoxin therapy may improve the prognosis of advanced heart failure patients with atrial fibrillation. However, no benefit of digoxin was demonstrated for patients in with sinus rhythm [15]. Routine measurement of serum digoxin concentration is probably not necessary in stable patients [16]. Laboratory tests may be done for ...
The age or gender of the person being tested, health history, the method used for the test, and many other factors may affect when and how often a lab test is required. The therapeutic range is 0.8 to 2.0ng/mL for those being treated for heart failure and levels ,4.0 ng/mL may be potentially life-threatening. This range for digoxin has been established over time. Once the dosage level is determined, digoxin levels are monitored routinely, at a frequency determined by the doctor, to verify correct dosage and if any changes occur in drug source, dosage, or other medications taken at the same time. Recent studies may help to improve patient selection for digoxin therapy, since Digoxin therapy may improve the prognosis of advanced heart failure patients with atrial fibrillation. However, no benefit of digoxin was demonstrated for patients in with sinus rhythm [15]. Routine measurement of serum digoxin concentration is probably not necessary in stable patients [16]. Laboratory tests may be done for ...
Inhibition of MCU by KB-R7943 may contribute to its cardioprotective activity by preventing mitochondrial Ca(2+)-overload during ischemia-reperfusion. In addition, the effects of KB-R7943 on Ca(2+) homeostasis provide new evidence for the role of mitochondria modulating Ca(2+)-release and regenerati …
Background: The aim of this study was to evaluate the histological and immunohistochemical effects of levosimendan on liver injury induced by myocardial ischemia and reperfusion (I/R) in a rat model. ...
Inotropes do not increase mortality in advanced heart failure Maya Guglin, Marc KaufmanUniversity of South Florida, Tampa, FL, USAAbstract: Inotrope use is one of the most controversial topics in the management of heart failure. While the heart failure community utilizes them and recognizes the state of inotrope dependency, retrospective analyses and registry data have overwhelmingly suggested high mortality, which is logically to be expected given the advanced disease states of those requiring their use. Currently, there is a relative paucity of randomized control trials due to the ethical dilemma of creating control groups by withholding inotropes from patients who require them. Nonetheless, results of such trials have been mixed. Many were also performed with agents no longer in use, on patients without an indication for inotropes, or at a time before automatic cardio-defibrillators were recommended for primary prevention. Thus, their results may not be generalizable to current clinical practice. In
Why is the doctor performing this test?. To determine how well the heart is pumping blood through the coronary arteries.. What is the test?. A dobutamine stress echo is a non-invasive ultrasound test which is used to visualize the heart in motion. To view the heart, your doctor will place a transducer on your chest which emits harmless sound waves to your heart. These sound waves generate pictures of your heart in motion and are displayed on an ultrasound machine connected to the transducer.. Your doctor will examine the muscle movement of the heart (also called wall motion) while you are at rest. Then, your doctor will inject a medication called dobutamine through an IV. This causes your heart to beat faster, simulating the effects exercise has on your heart. The doctor will then examine these pictures of your heart and compare them to the pictures taken while you were at rest.. If the results of your stress echo show decreased muscle movement (or wall motion) during stress than while resting, ...
Dobutamine stress echocardiograms are used to diagnose certain heart conditions. This type of echocardiogram was created for patients who are physically unable to exercise on a treadmill or stationary cycle. This type of echocardiogram utilizes a special medication called dobutamine. Essentially, this medication mimics regular echocardiograms, stimulating your heart so it appears that you are exercising. The dobutamine allows cardiologists to:. ...
A dobutamine stress echocardiogram is a diagnostic test to assess the heart muscle under stress. If exercise on a treadmill is not an option (too much stress on the heart) due to a persons medical condition, a doctor may use an intravenous medicine called dobutamine. Dobutamine causes the heart to beat faster and will mimic the effects of exercise on the heart.
The apelin peptide is described as one of the most potent inotropic agents, produced endogenously in a wide range of cells, including cardiomyocytes. Despite positive effects on cardiac contractility in multicellular preparations, as well as indications of cardio-protective actions in several diseases, its effects and mechanisms of action at the cellular level are incompletely understood. Here, we report apelin effects on dynamic mechanical characteristics of single ventricular cardiomyocytes, isolated from mouse models (control, apelin-deficient [Apelin-KO], apelin-receptor KO mouse [APJ-KO]), and rat. Dynamic changes in maximal velocity of cell shortening and relaxation were monitored. In addition, more traditional indicators of inotropic effects, such as maximum shortening (in mechanically unloaded cells) or peak force development (in auxotonic contracting cells, preloaded using the carbon fibre technique) were studied. The key finding is that, using Apelin-KO cardiomyocytes exposed to different
A stress echo is a test that takes pictures of the heart with the use of a probe placed outside your chest wall while your heart is working hard. To stress the heart, youll be given an intravenous medication (Dobutamine) that will make your heart beat harder and faster just like it would during exercise. ​​. The pictures taken before, during and after your heart is stressed are displayed on the ultrasound monitor and are recorded on a disk for review and comparison. A dobutamine stress echo is performed by a sonographer and interpreted by a cardiologist ...
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Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine is a catecholamine for a pharmacological cardiac stress agen. - Mechanism of Action & Protocol.
Dobutamine Stress Echocardiogram clinics in Bismarckstrasse at the best price. Find doctors, specialized in Cardiology and compare prices, costs and reviews.
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We have previously reported that leptin protects the mouse myocardium against I/R injury through a direct action on the heart (24). It has been proposed that the activation of the so-called RISK pathway, which incorporates the PI3K-Akt and p44/42 cascades, is a prerequisite for cardioprotection induced by ischemic preconditioning (IPC) and various pharmacological mediators (14). Indeed, previous studies from this laboratory (8, 24) and the current investigation have yielded evidence that supports this theory further, as the cardioprotective actions of leptin were also found to involve RISK pathway activation (24). Nevertheless, it is generally accepted that cell signaling pathways in addition to PI3K-Akt and p44/42 also underlie cardioprotection. The JAK/STAT pathway, which is known to modulate the metabolic actions of leptin, may constitute one such mechanism (10). In the present study, therefore, we continued our investigations into the cardioprotective actions of leptin but focusing on the ...
Drug Information on dobutamine includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid.
dobutamine.%27%27 davis pdf, Visual compatibility of dobutamine with seven parenteral drug products. Am J Hosp Pharm 1980 ; 37: 460,464. 1611 Revue Chalmers JR, Bobek MB, Militello MA. Visual compatibility of amiodarone hydrochloride injection with various intravenous drugs. Am J Health-Syst Pharm 2001 ; 58: 504-506. 1625 Revue Trissel LA, Saenz C, Williams YW, Ingram D.
COVID-19 cases, hospitalizations and deaths continue to head upwards in Wisconsin. The state Department of Health Services Thursday update included more than 9500 new positive cases, 223 additional hospitalizations and 38 deaths. Governor Tony Evers continues to urge everyone to do the right thing, by wearing masks, social distancing and avoiding group gatherings. We can ...
Twenty-six states are reporting rising numbers of new coronavirus cases as the first wave of the COVID-19 outbreak in the U.S. rages on. Upticks in Arizona have health experts particularly worried. An ABC News analysis of New York Times data found that new positive cases, hospitalizations and deaths
The state reported 5,885 new positive coronavirus cases and 42 new deaths. The Tampa Bay region reported four new deaths in Wednesdays report.
In the shortened Labor Day holiday week, new virus cases and quarantines in Sumter School District last week were at their lowest level so far this year. After recording 190 new positive COVID-19 cases among students and staff and directing 2,064 …
Levosimendan,[[4-[(4R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile,(-)-[p[(R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazone mesoxalonitrile,(R)-simendan,OR-1259,Simdax
... (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose- ...
... (INN) is a cardiotonic agent. It has been marketed in Japan since 1996. Uemura Y, Tanaka S, Ida S, Yuzuriha T ( ... a new cardiotonic agent, in beagle dogs". J. Pharm. Pharmacol. 45 (12): 1077-81. doi:10.1111/j.2042-7158.1993.tb07184.x. PMID ...
... has no apparent inotropic properties and may be a cardiotonic agent. It is used for the symptomatic treatment of ... It can be used as a bradycardic agent as it has shown to inhibit the If current. Ivabradine is contraindicated in sick sinus ...
... a new cardiotonic agent, in beagle dogs". The Journal of Pharmacy and Pharmacology. 45 (12): 1077-81. doi:10.1111/j.2042- ... Antineoplastic agents: Imidazo[1,5-a]pyridines: Fadrozole (brand name Afema)-an aromatase inhibitor. Imidazo[4,5-c]pyridines: 3 ... Directly-acting antiviral agents: Imidazo[1,2-a]pyridines: Tegobuvir (GS-9190) - an allosteric, non-nucleoside hepatitis C ... Zolimidine-a gastroprotective agent. Linaprazan-a potassium-competitive acid blocker which demonstrated similar efficacy as ...
... is a cardiac glycoside and an anti-arrhythmia and cardiotonic agent. Tilford GL. Edible and Medicinal plants of the ...
Dogbane contains cymarin, a cardiotonic agent formerly used to treat cardiac arrhythmia in humans. Almost 300 names have been ...
... a new class of cardiotonic agents". Journal of Medicinal Chemistry. 25 (12): 1477-1481. doi:10.1021/jm00354a017. ISSN 0022-2623 ...
Parsons WJ, Ramkumar V, Stiles GL (April 1988). "The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and ... Sulmazole is a cardiotonic drug. Sulmazole has the chemical formula C14H13N3O2S and a molecular weight of 287.34 g/mol. ...
... a structurally novel cardiotonic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 520-30. ... Quazinone (Dozonone) is a cardiotonic and vasodilator drug which was developed and marketed in the 1980s for the treatment of ... Phosphodiesterase inhibitor David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN ... a novel positive inotropic agent with vasodilating properties". Journal of Cardiovascular Pharmacology. 6 (3): 511-9. doi: ...
A weak tea made from the dried root has been used for cardiac diseases and also as a vermifuge (an agent that expels parasitic ... The root has been used as a tonic, cardiotonic, diaphoretic, diuretic, emetic (induces vomitting) and expectorant. It is ...
Antiparkinsonian agent Trimetazidine - Antianginal Vesnarinone - Cardiotonic Designer drugs 3-Methylbenzylpiperazine 4-Methyl-1 ... Gastrointestinal agent Fipexide - Nootropic Imatinib - Anticancer agent Meclozine - Antihistamine Piberaline - Antidepressant ... It is often claimed that BZP was originally synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm ...
In humans, higenamine has been studied as an investigational drug in China for use as a pharmacological agent for cardiac ... In a rodent model, it was found that higenamine produced cardiotonic, vascular relaxation, and bronchodilator effects. In ...
... and the calcium channel blocking agents. As new pharmacotherapeutic agents arise, the use of digitalis preparations is expected ... Its cardiotonic effects slows atrioventricular conduction so that the heartbeat slows down and slightly increases contraction ...
Theophylline is a non-selective agent. In contrast, meribendan is a highly selective inhibitor. Also, meribendan has a higher ... site A sterically hindered site An area with bulk tolerance Since selective PDE3 inhibitors were recognised to be cardiotonic ...
There are many medicinal uses from the plant Adonis vernalis, but it is well known for being used as a cardiotonic (having a ... and an ethanolic extract of the aerial parts of the plant were prepared as an alternative cardiac agent. In 1879, a Russian ...
... a beta 1-adrenoceptor-selective blocking agent, for beta-adrenoceptors in the bovine trachea and heart". British Journal of ... helped understand the relationship between polyamine modifying drugs and isoproterenol-elicited cardiotonic effect. When 3H- ...
Plant-derived products have long been and will continue to be important sources of medical agents and models for the design, ... cardiotonic, demulcent, hypotensive, sedative, and vasoconstrictor, with the following warning added: "Always seek advice from ...
... cardiotonic agents MeSH D27.505.954.411.320 - fibrinolytic agents MeSH D27.505.954.411.455 - natriuretic agents MeSH D27.505. ... cardiotonic agents MeSH D27.720.799.113 - cariostatic agents MeSH D27.720.799.180 - cryoprotective agents MeSH D27.720.799.763 ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...
Irie, K.; Sato, T.; Tanaka, I.; Nakajima, J.; Kawaguchi, M.; Himi, T. (2009). "Cardiotonic effect of Apocynum venetum L. ... phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against ...
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; ... Cardiotonic Agents (Cardiac Stimulants). Subscribe to New Research on Cardiotonic Agents Agents that have a strengthening ... Cardiac Stimulants; Cardiotonic Drugs; Cardiotonics; Cardioprotective Agents; Inotropic Agents, Positive Cardiac; Myocardial ... It is concluded that cardiotonic agents increasing the cardiac myofibrillar sensitivity to Ca ions would be beneficial in both ...
Xestoquinone, a novel cardiotonic agent activates actomyosin ATPase to enhance contractility of skinned cardiac or skeletal ... Xestoquinone, a novel cardiotonic agent activates actomyosin ATPase to enhance contractility of skinned cardiac or skeletal ... Xestoquinone, a novel cardiotonic agent activates actomyosin ATPase to enhance contractility of skinned cardiac or skeletal ... Xestoquinone, a novel cardiotonic agent activates actomyosin ATPase to enhance contractility of skinned cardiac or skeletal ...
Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. ... Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. ... Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. ... Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. ...
Agents. CP was purchased from Tasly Pharmaceutical Co., Ltd. (Tianjin, China). An analysis by high performance liquid ... Cardiotonic pill (CP), consisting of Salvia miltiorrhiza (SM), Panax notoginseng (PN), and Borneol, is a widely used ... Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris. Our ... X. H. Wei, Y. Y. Liu, Q. Li et al., "Treatment with cardiotonic pills after ischemia-reperfusion ameliorates myocardial ...
Seven patients with severe chronic congestive heart failure were treated with a new cardiotonic agent, WIN 47203 (an analog of ... T1 - Long-term therapy with a new cardiotonic agent, WIN 47203. T2 - Drug-dependent improvement in cardiac performance and ... N2 - Seven patients with severe chronic congestive heart failure were treated with a new cardiotonic agent, WIN 47203 (an ... AB - Seven patients with severe chronic congestive heart failure were treated with a new cardiotonic agent, WIN 47203 (an ...
Milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy ...
Fingerprint Dive into the research topics of Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203 ... T1 - Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart ... Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart ... title = "Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive ...
... has role cardiotonic drug (CHEBI:38147) dopamine (CHEBI:18243) has role dopaminergic agent (CHEBI:48560 ... An agent that selectively binds to and activates beta. -adrenergic receptors.. dopaminergic agent A drug used for its effects ... dopaminergic agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of ... dopamine (CHEBI:18243) has role sympathomimetic agent (CHEBI:35524) dopamine (CHEBI:18243) is a catecholamine (CHEBI:33567) ...
Cardiotonic Agents/therapeutic use*. *Coronary Angiography. *Coronary Artery Bypass*. *Coronary Disease/complications ... The antithrombin agent in both groups was enoxaparin. The co-primary endpoints were a combined rate of death, non-fatal ...
cardioprotective agent Any protective agent that is able to prevent damage to the heart. ... 3-O-acetyldigitoxin (CHEBI:53773) has role cardiotonic drug (CHEBI:38147) 3-O-acetyldigitoxin (CHEBI:53773) has role ... A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the ... cardiotonic drug A drug that has a strengthening effect on the heart or that can increase cardiac output. ...
The Cardiotonic Agent Amrinone Does Not Increase Anatomic Infarct Size. Campbell, Colin A.; Mehta, Prabodh M.; Wynne, Joshua; ... Mode of Cardiotonic Action of Helenalin, a Sesquiterpene Lactone, on Guinea Pig Ventricular Myocardium. Itoigawa, Masataka; ... Influence of AQ-A39, a Bradycardic Agent, on Cardiovascular Responses to Isoproterenol in the Anesthetized Dog. Wenger, Herbert ...
Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. Cardiotonic Agents. ... Antiparkinson Agents. Anti-Dyskinesia Agents. Dopamine Agents. ... Autonomic Agents. Peripheral Nervous System Agents. Protective ...
Cardiotonic Agents. Sympathomimetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. ...
Cardiotonic Agents. Platelet Aggregation Inhibitors. Vasodilator Agents. Phosphodiesterase 3 Inhibitors. Phosphodiesterase ... Receipt of any investigational agent or drug within 30 days or 5 half-lives (whichever is longer) prior to the first dose of ...
Dopamine Agents. Neurotransmitter Agents. Cardiotonic Agents. Sympathomimetics. Autonomic Agents. Peripheral Nervous System ... Protective Agents. Antipsychotic Agents. Tranquilizing Agents. Central Nervous System Depressants. Psychotropic Drugs. Dopamine ...
Vesnarinone (INN) is a cardiotonic agent. A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose- ...
Olprinone (INN) is a cardiotonic agent. It has been marketed in Japan since 1996. Uemura Y, Tanaka S, Ida S, Yuzuriha T ( ... a new cardiotonic agent, in beagle dogs". J. Pharm. Pharmacol. 45 (12): 1077-81. doi:10.1111/j.2042-7158.1993.tb07184.x. PMID ...
Anti-Inflammatory Agents, Non-Steroidal* * Antioxidants* * Cardiotonic Agents* * Cardiovascular Diseases / prevention & control ... Green tea polyphenols as an anti-oxidant and anti-inflammatory agent for cardiovascular protection Cardiovasc Hematol Disord ...
Cardiotonic Agents / metabolism* * Fetus / metabolism * Heart Failure / blood * Heart Failure / pathology * Heart Failure / ...
HPLC showed that plasma and tissues contained one main peak of immunoreactivity corresponding to the infused agent. Systolic ...
Pharmacological Actions : Cardiotonic Agents. [+] Thiamine deficiency may play an important etiologic role in the deterioration ... L-carnitine is a useful therapeutic agent for the treatment of congestive heart failure in combination with traditional ... Pubmed Data : Cardiovasc Hematol Agents Med Chem. 2007 Oct;5(4):295-9. PMID: 17979692 ... reduces the inflammatory milieu in congestive heart failure patients and might serve as a new antiinflammatory agent for the ...
Cardiotonic Agents. *MalaCards. *Medline Plus. Pharma. 782. Dopamine Agents. *MalaCards. *Medline Plus ...
Cardiotonic Agents*. Catalase / blood. Coronary Vessels / physiology. Curcumin / analogs & derivatives*, pharmacology. ...
Cardiotonic Agents. Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ...
Cardiotonic Agents. 1. 10. Fertility Agents: Male. 1. 10. Anti-Inflammatory Agents. 2. 3. ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-6 Downregulation, Tumor Necrosis Factor (TNF) ...
Anti-Glycation Agents. 46. 19. Cardiotonic Agents. 46. 7. Lipolytic. 45. 16. ...
Cardiotonic Agents. Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ...
Pharmacological Actions : Cardiotonic Agents. Additional Keywords : Drug: Digoxin, Plant Extracts, Superiority of Natural ... A water extract of the heartwood of Pterocarpus compares favorably to digoxin as a cardiotonic agent. Jun 01, 2007. ...
... neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must- ... Structure-Activity Relationships of Steroidal Neuromuscular Blocking Agents Z. Tuba and S. Maho 12. Molecular Biology of ...
Cardiotonic Agents / therapeutic use. Coronary Circulation*. Humans. Myocardial Reperfusion*. Perfusion. Risk Factors. Shock, ...
  • Garlic and its preparations have been widely recognized as agents for prevention and treatment of cardiovascular disease, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. (thepeopleschemist.com)
  • This sample expert has 24 years of experience, and specializes in the field of organic chemistry, cardiovascular and CNS drugs with specific knowledge in the areas of antipsychotic, anti-anxiety, analgesia, hypertension, cardiotonic agents, ion channel modulators, vaccine adjuvants and drug delivery. (roundtablegroup.com)
  • In addition to being a sweetening agent, Stevia has been used as a cardiotonic for hypertension and heartburn and also to lower uric acid levels. (plantphysiol.org)
  • Larry Dial, Jiang Liu and Joseph I. Shapiro, "Cardiotonic Steroids in Adaptation to Dietary Salt Intake", Current Clinical Pharmacology (2014) 9: 298. (eurekaselect.com)
  • The drugs Dopamine and Neurotransmitter Agents have been mentioned in the context of this disorder. (malacards.org)
  • Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. (aspetjournals.org)
  • a glycoside obtained from Digitalis lanata , used as a cardiotonic like digitalis. (thefreedictionary.com)
  • Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Withering's seminal monograph on foxglove. (ahajournals.org)
  • Unlike most other inotropic agents, it also exhibits antiarrhythmic properties. (thepeopleschemist.com)
  • These drugs are positive inotropic agents and enhance cardiac contraction. (ahajournals.org)
  • Intravenous positive inotropic agents play a central role in the short-term management of patients with decompensated heart failure resulting from left ventricular systolic dysfunction. (ahajournals.org)
  • We hypothesized that another NaCl sensitive endogenous natriuretic factor, i.e., marinobufagenin (MBG), a specific ligand of the α-1 subunit of Na/K ATPase (the main kidney isoform) and also a vasoconstrictor and cardiotonic substance, would be elevated in CHF patients in a graded manner with the severity of CHF. (elsevier.com)
  • No sodium bicarbonate, antiarrhythmics, or cardiotonic agents were provided to the CPB group during this resuscitation. (nih.gov)
  • Although these agents improve hemodynamics rapidly, their use may be limited by several factors. (ahajournals.org)
  • Soporific Agents (Hypnotics and Sedative Drugs) 5. (researchandmarkets.com)
  • Cardiotonic Inotropic Drugs 18. (researchandmarkets.com)
  • In the area of antiarrhythmic therapy, the clinical use of a number of drugs has been hampered by the pro-arrhythmogenic actions of these agents. (springer.com)
  • The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. (routledge.com)
  • In this review, we will focus on the effect of the newly appreciated cardiotonic steroids (CTS)-Na/K-ATPase signaling on RPT-mediated sodium handling by coordinated regulation of the Na/K-ATPase and sodium/proton exchanger isoform 3 (NHE3). (eurekaselect.com)
  • The "cardiotonic steroids" cause cardiac muscle to lose K + and gain Na + because they inhibit the Na + pump (Na + ,K + -ATPase), a plasma membrane protein, present in all cells. (ahajournals.org)
  • Evidence has been provided by this group, and by others, that cardiotonic steroids activate intracellular signaling pathways through Na/K-ATPase-Src-Ras-ROS and extracellular signal regulated kinase within restricted membrane subdomains, referred to as caveolae. (ahajournals.org)
  • These data have shifted the focus of cardiotonic steroids from their pharmacological effects on the enzymatic function of the Na/K-ATPase to intracellular signaling functions triggering growth and cell proliferation. (ahajournals.org)
  • Decreases in heart rate and blood pressure commonly seen with β-blockers overdoses are initially treated with intravascular fluid, vasopressor agents (e.g., norepinephrine, epinephrine) and cardiotonic agents (e.g., dobutamine, isoproterenol, milrinone, amrinone, enoximone). (elsevier.com)
  • Seven patients with severe chronic congestive heart failure were treated with a new cardiotonic agent, WIN 47203 (an analog of amrinone), for an average of 7.4 weeks (range 2 to 15). (elsevier.com)
  • Le Jemtel, Thierry H. / Long-term therapy with a new cardiotonic agent, WIN 47203 : Drug-dependent improvement in cardiac performance and progression of the underlying disease . (elsevier.com)
  • The hemodynamic and clinical effects of WIN 47203, a newly synthesized noncatecholamine, nonglycosidic inotropic agent, were studied in 11 patients with severe chronic congestive heart failure. (elsevier.com)
  • Therefore, this study demonstrates the acute and sustained cardiotonic efficacy of WIN 47203 in man. (elsevier.com)
  • Ouabain, a cardiotonic steroid, has previously been identified as an antiapoptotic agent that in subsaturating concentrations protect from intrinsic apoptosis. (diva-portal.org)
  • d) the perspectives on the most promising strategies for limiting or preventing anthracycline-induced cardiotoxicity, focusing on controversial aspects and on recent data regarding analogues of the natural compounds, tumor-targeted formulations and cardioprotective agents. (curehunter.com)
  • It is used in the treatment of asthma, hoarseness, insanity, epilepsy and as a potent nerve tonic, cardiotonic and diuretic. (fuzing.com)
  • Beta-adrenergic antagonist agents, routinely known as β-blockers, are commonly prescribed agents for the treatment of cardiac and other diseases. (elsevier.com)
  • It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY. (nih.gov)
  • 8 These agents do not usually increase the intracellular concentration of cAMP and thus do not have the limitations of causing increased heart rate and stimulation of arrhythmias. (ahajournals.org)
  • Animal studies have shown that this agent dilates porcine coronary arteries by opening potassium channels, a relaxation effect that is independent of intracellular free calcium. (ahajournals.org)
  • 5 The sesquiterpenes are 15-carbon terpenoids that seem to act as anti-inflammatory agents, tonifying muscles and nerves and strengthening connective tissue. (ndnr.com)
  • A method is described for the determination of plasma concentration of (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), a new, selectively inotropic cardiotonic agent, based on selected ion monitoring gas chromatography-mass spectrometry. (aspetjournals.org)
  • An agent that selectively binds to and activates beta -adrenergic receptors. (ebi.ac.uk)
  • The present invention concerns compounds of following general formula (I): (Formula I) and their pharmaceutically acceptable salts, their method of preparation and their uses, notably as anticancer agent. (patents.com)
  • Phenylephrine HCl acts as a mydriatic, nasal decongestant, and cardiotonic agent. (tradeindia.com)
  • An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent. (nih.gov)
  • Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris. (hindawi.com)
  • A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (ebi.ac.uk)
  • PURPOSE: To provide a carcinostatic agent containing a specific benzoylurea compound as an active component. (google.com)
  • Our data demonstrate ORM-3819 as a potent positive inotropic agent exerting its cardiotonic effect by a cTnC-dependent Ca 2+ -sensitizing mechanism in combination with the selective inhibition of the PDE III isozyme. (elsevier.com)
  • The active components of this slow-acting cardiotonic agent are thought to be flavonoids and oligomeric procyanidins. (thepeopleschemist.com)
  • It has been reported to be an anti-anxiety agent having adaptogenic effect. (fuzing.com)
  • an agent which blocks the stimulation of cells by histamine. (entremkt.com)
  • Moreover, it is used in Ayurveda for the treatment of asthma, crackling, mental disorders, having a mild nuerotonic and cardiotonic effect. (feedthechildren.org.uk)
  • This medication is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, tracheobronchitis (respiratory tract inflammation), bronchiectasis, bronchitis with bronchospasm asthma. (medindia.net)
  • At the same, the medication is a strong blood-purifying agent on the specific effect of chronic skin diseases. (feedthechildren.org.uk)
  • Agents that have a strengthening effect on the heart or that can increase cardiac output. (curehunter.com)
  • an agent that produces the effect of the chmical transmitter acetylcholine. (entremkt.com)
  • The preparation is produced by spraying a solution of a polymer containing a drug and an aqueous solution of an agent for preventing aggregation of the microparticles separately from different nozzles and contacting them with each other in a spray dryer. (google.es)
  • The present invention relates to a microparticle preparation comprising microparticles of a polymer which contain a drug and are coated with a film of an agent for preventing aggregation of the microparticles (hereinafter sometimes referred to as a microparticle preparation) and the production thereof by spray drying. (google.es)
  • Any protective agent that is able to prevent damage to the heart. (ebi.ac.uk)
  • Background- Levosimendan is a calcium-sensitizing agent and an inodilator under current investigation in the treatment of decompensated heart failure. (ahajournals.org)