Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Surgery performed on the heart.
A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Devices which mechanically oxygenate venous blood extracorporeally. They are used in combination with one or more pumps for maintaining circulation during open heart surgery and for assisting the circulation in patients seriously ill with some cardiac and pulmonary disorders. (UMDNS, 1999)
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
The period following a surgical operation.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Elements of limited time intervals, contributing to particular results or situations.
The period during a surgical operation.
Making an incision in the STERNUM.
Coagulant substances inhibiting the anticoagulant action of heparin.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Application of heat to correct hypothermia, accidental or induced.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
Devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers. (Dorland, 28th ed)
Loss of blood during a surgical procedure.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
A long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Surgery performed on the heart or blood vessels.
Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
Apparatus that provides mechanical circulatory support during open-heart surgery, by passing the heart to facilitate surgery on the organ. The basic function of the machine is to oxygenate the body's venous supply of blood and then pump it back into the arterial system. The machine also provides intracardiac suction, filtration, and temperature control. Some of the more important components of these machines include pumps, oxygenators, temperature regulators, and filters. (UMDNS, 1999)
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The time required by whole blood to produce a visible clot.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
Surgical incision into the chest wall.
Blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.
The act of constricting.
The measure of the level of heat of a human or animal.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The period of confinement of a patient to a hospital or other health facility.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Rhythmic compression of the heart by pressure applied manually over the sternum (closed heart massage) or directly to the heart through an opening in the chest wall (open heart massage). It is done to reinstate and maintain circulation. (Dorland, 28th ed)
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The design or construction of objects greatly reduced in scale.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Interventions to provide care prior to, during, and immediately after surgery.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.
Measurement of oxygen and carbon dioxide in the blood.
Operative procedures for the treatment of vascular disorders.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Pumping that aids the natural activity of the heart. (Dorland, 27th ed)
Antifibrinolytic hemostatic used in severe hemorrhage.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Control of bleeding during or after surgery.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
The vein which drains the foot and leg.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Methods of creating machines and devices.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
General or unspecified injuries to the heart.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.
Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
The chambers of the heart, to which the BLOOD returns from the circulation.
Shock resulting from diminution of cardiac output in heart disease.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
The period before a surgical operation.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Method of measuring performance against established standards of best practice.
Cardiac electrical stimulators that apply brief high-voltage electroshocks to the HEART. These stimulators are used to restore normal rhythm and contractile function in hearts of patients who are experiencing VENTRICULAR FIBRILLATION or ventricular tachycardia (TACHYCARDIA, VENTRICULAR) that is not accompanied by a palpable PULSE. Some defibrillators may also be used to correct certain noncritical dysrhythmias (called synchronized defibrillation or CARDIOVERSION), using relatively low-level discharges synchronized to the patient's ECG waveform. (UMDNS, 2003)
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Plastic tubes used for drainage of air or fluid from the pleural space. Their surgical insertion is called tube thoracostomy.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The circulation of the BLOOD through the LUNGS.
Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
A curare alkaloid that is a very potent competitive nicotinic antagonist at the neuromuscular junction.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Lower than normal body temperature, especially in warm-blooded animals.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Surgery performed on the thoracic organs, most commonly the lungs and the heart.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological processes involving any part of the LUNG.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
Pathological processes involving any part of the AORTA.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Agents that prevent clotting.
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
The determination of oxygen-hemoglobin saturation of blood either by withdrawing a sample and passing it through a classical photoelectric oximeter or by electrodes attached to some translucent part of the body like finger, earlobe, or skin fold. It includes non-invasive oxygen monitoring by pulse oximetry.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
Services specifically designed, staffed, and equipped for the emergency care of patients.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
An infant during the first month after birth.
The valve between the left atrium and left ventricle of the heart.
An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Obstruction of flow in biological or prosthetic vascular grafts.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Removal of an implanted therapeutic or prosthetic device.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Diversion of the flow of blood from the entrance to the right atrium directly to the pulmonary arteries, avoiding the right atrium and right ventricle (Dorland, 28th ed). This a permanent procedure often performed to bypass a congenitally deformed right atrium or right ventricle.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Situations or conditions requiring immediate intervention to avoid serious adverse results.
The natural enzymatic dissolution of FIBRIN.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
The flow of BLOOD through or around an organ or region of the body.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. (1/1874)

BACKGROUND: The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied. METHODS: Sagittal sinus catheters and cortical microdialysis catheters were inserted into anesthetized pigs. Animals undergoing normothermic cardiopulmonary bypass were pretreated with lamotrigine 0, 10, 25, or 50 mg/kg (n = 10 per group). Fifteen minutes of global cerebral ischemia was produced, followed by 40 min of reperfusion and discontinuation of cardiopulmonary bypass. Cerebral oxygen metabolism was calculated using cerebral blood flow (radioactive microspheres) and arterial-venous oxygen content gradients. Concentrations of microdialysate glutamate and aspartate were quantified; electroencephalographic signals were recorded. After cardiopulmonary bypass, blood and cerebrospinal fluid were sampled for S-100B protein, and a biopsy was performed on the cerebral cortex for metabolic profile. RESULTS: Lamotrigine caused dose-dependent reductions in systemic vascular resistance so that additional fluid was required to maintain venous return. Concentrations of glutamate and aspartate did not change during reperfusion after 50 mg/kg lamotrigine in contrast to fivefold and twofold increases, respectively, with lower doses. There were no intergroup differences in cerebral metabolism, electroencephalographic scores, cortical metabolites, brain lactate, or S-100B protein concentrations in the cerebrospinal fluid and blood. CONCLUSIONS: Lamotrigine 50 mg/kg significantly attenuated excitatory neurotransmitter release during normothermic cerebral ischemia during cardiopulmonary bypass without improving other neurologic parameters. Lamotrigine caused arterial and venous dilation, which limits its clinical usefulness.  (+info)

Biventricular repair approach in ducto-dependent neonates with hypoplastic but morphologically normal left ventricle. (2/1874)

OBJECTIVES: Increased afterload and multilevel LV obstruction is constant. We assumed that restoration of normal loading conditions by relief of LV obstructions promotes its growth, provided that part of the cardiac output was preoperatively supported by the LV, whatever the echocardiographic indexes. BACKGROUND: Whether to perform uni- or biventricular repair in ducto dependent neonates with hypoplastic but morphologically normal LV (hypoplastic left heart syndrome classes II & III) remains unanswered. Echocardiographic criteria have been proposed for surgical decision. METHODS: Twenty ducto dependent neonates presented with this anomaly. All had aortic coarctation associated to multilevel LV obstruction. Preoperative echocardiographic assessment showed: mean EDLW of 12.4 +/- 3.03 ml/m2 and mean Rhodes score of -1.73 +/-0.8. Surgery consisted in relief of LV outflow tract obstruction by coarctation repair in all associated to aortic commissurotomy in one and ASD closure in 2. RESULTS: There were 3 early and 2 late deaths. Failure of biventricular repair and LV growth was obvious in patients with severe anatomic mitral stenosis. The other demonstrated growth of the left heart. At hospital discharge the EDLVV was 19.4+/-3.12 ml/m2 (p = 0.0001) and the Rhodes score was -0.38+/-1.01 (p = 0.0003). Actuarial survival and freedom from reoperation rates at 5 years were 72.5% and 46%, respectively. CONCLUSIONS: Biventricular repair can be proposed to ducto dependent neonates with hypoplastic but morphologically normal LV provided that all anatomical causes of LV obstruction can be relieved. Secondary growth of the left heart then occurs; however, the reoperation rate is high.  (+info)

Coronary sinus adrenomedullin rises in response to myocardial injury. (3/1874)

Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated levels of the cardiospecific protein troponin-T (Tn-T) during cardiopulmonary bypass. ADM (pg/ml) and Tn-T (ng/ml) were measured in coronary sinus blood before and after aortic cross-clamp and in venous blood 6 h after surgery in 22 coronary-bypass patients. Based on the pre- and post-clamp Tn-T levels in the coronary sinus, the patients were divided into group I (no change; n=10) and group II (two times increase; n=12). Baseline ADM (362.7+/-106.2 and 303+/-58.7 pg/ml in groups I and II respectively; means+/-S.D.) and Tn-T (0.66+/-0.14 and 0.57+/-0.13 ng/ml respectively) levels were similar in both groups. In group I, the post-clamp ADM (317.6+/-80.8 pg/ml) and Tn-T (0.68+/-0.15 ng/ml) levels did not change significantly. In group II, the post-clamp ADM levels rose significantly above the baseline, mimicking the change in Tn-T (ADM, 541.4+/-89.4 pg/ml; Tn-T, 1.37+/-0.31 ng/ml; P=0.009). After 6 h, the systemic Tn-T levels were similar in both groups (2. 09+/-0.44 and 1.95+/-0.52 ng/ml in groups I and II respectively). We suggest that: (1) minor degrees of myocardial ischaemic damage result in release of ADM by the heart, and (2) ADM may play a protective role in the myocardium during an ischaemic insult. This suggests a possible therapeutic role for ADM in the management of intra-operative myocardial ischaemia.  (+info)

Transitory cerebral microvascular blockade after cardiopulmonary bypass. (4/1874)

Dogs were submitted to cardiopulmonary bypass (CPB) carried out under conditions calculated to generate large numbers of microbubbles and microemboli. On the day following the procedure the dogs showed evidence of neurological damage including impaired consciousness and ataxia. These abnormalities largely cleared within a week. When the animals were sacrificed at intervals after the procedure, the cerebral microvasculature was demonstrated by injecting a suspension a lamp black into the carotid artery. This revealed that multiple filling defects were present in the microcirculation of the brain immmediately after CPB and for two days thereafter. However, by seven days the microvascular blockade had disappeared, and the vascular blockade had disappeared, and the vascular pattern of the brain had returned to normal. Neuropathological findings were sparse and restricted to the cerebellum. This study suggests that the transient neurological syndromes that sometimes follow cardiopulmonary bypass for heart surgery may be due to a transient microvascular blockade, perhaps by microbubbles and microparticles.  (+info)

A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction. (5/1874)

Milrinone is used during cardiac surgery to facilitate separation from cardiopulmonary bypass (CPB) and/or to treat myocardial dysfunction in the post-bypass period. We have demonstrated, in patients with preoperative depression of systolic function undergoing aorto-coronary artery bypass surgery, sustained improvement in cardiac function after a single loading dose of milrinone 50 micrograms kg-1, administered at the end of bypass, thus significantly decreasing the need for beta-agonist therapy.  (+info)

Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) and Apo(a) fragments. (6/1874)

Fragments of apolipoprotein(a) [apo(a)], the distinctive glycoprotein of lipoprotein(a) [Lp(a)], are present in human plasma and urine and have been implicated in the development of atherosclerosis. The mechanism responsible for the generation of apo(a) fragments in vivo is poorly understood. In this study, we examined the plasma levels of Lp(a) and apo(a) fragments [or free apo(a)] and urinary apo(a) in 15 subjects who underwent cardiac surgery necessitating cardiopulmonary bypass. We also measured the plasma concentration and activity of polymorphonuclear elastase, an Lp(a)-cleaving enzyme in vitro, and plasma levels of C-reactive protein. Despite a marked activation of polymorphonuclear cells and a pronounced inflammatory response, as documented by an 8-fold and a 35-fold increase in plasma levels of polymorphonuclear elastase and C-reactive protein, respectively, the proportion of plasma free apo(a) to Lp(a) and urinary excretion of apo(a) remained unchanged over a 7-day period after surgery, and polymorphonuclear elastase activity remained undetectable in plasma. No fragmentation of apo(a) was observed ex vivo in plasma samples collected before and after surgery. These data indicate that in this model, apo(a) is not fragmented in plasma and are consistent with the hypothesis that apo(a) fragments result from a constitutively active tissue mechanism that is not modified by cardiac surgery with cardiopulmonary bypass.  (+info)

Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart with conventional coronary artery surgery with cardiopulmonary bypass. (7/1874)

OBJECTIVE: To compare cardiac troponin T release and lactate metabolism in coronary sinus and arterial blood during uncomplicated coronary grafting on the beating heart with conventional coronary grafting using cardiopulmonary bypass. DESIGN: A prospective observational study with simultaneous sampling of coronary sinus and arterial blood: before and 1, 4, 10, and 20 minutes after reperfusion for analysis of cardiac troponin T and lactate. Cardiac troponin T was also analysed in venous samples taken 3, 6, 24, 48, and 72 hours after surgery. SETTING: Cardiac surgical unit in a tertiary referral centre. PATIENTS: 18 patients undergoing coronary grafting on the beating heart (10 single vessel and eight two-vessel grafting) and eight undergoing two-vessel grafting with cardiopulmonary bypass. RESULTS: Cardiac troponin T was detected in coronary sinus blood in all patients by 20 minutes after beating heart coronary artery surgery before arterial concentrations were consistently increased. Peak arterial and coronary sinus cardiac troponin T values on the beating heart during single (0.03 (0 to 0. 05) and 0.09 (0.07 to 0.16 microg/l, respectively) and two-vessel grafting (0.1 (0.07 to 0.11) and 0.19 (0.14 to 0.25) microg/l) were lower than the values obtained during cardiopulmonary bypass (0.64 (0.52 to 0.72) and 1.4 (0.9 to 2.0) microg/l) (p < 0.05). The area under the curve of venous cardiac troponin T over 72 hours for two-vessel grafting on the beating heart was less than with cardiopulmonary bypass (13 (10 to 16) v 68 (26 to 102) microg.h/l) (p < 0.001). Lactate extraction began within one minute of snare release during beating heart coronary surgery while lactate was still being produced 20 minutes after cross clamp release following cardiopulmonary bypass. CONCLUSIONS: Lower intraoperative and serial venous cardiac troponin T concentrations suggest a lesser degree of myocyte injury during beating heart coronary artery surgery than during cardiopulmonary bypass. Oxidative metabolism also recovers more rapidly with beating heart coronary artery surgery than with conventional coronary grafting. Coronary sinus cardiac troponin T concentrations increased earlier and were greater than arterial concentrations during beating heart surgery, suggesting that this may be a more sensitive method of intraoperative assessment of myocardial injury.  (+info)

Urgent homograft aortic root replacement for aortic root abscess in infants and children. (8/1874)

OBJECTIVE: To assess the results of early homograft aortic root replacement in infants and children with an aortic root abscess. DESIGN: Descriptive study of all patients with an aortic root abscess during 1987-97, identified by retrospective review of the echocardiographic and surgical registries. SETTING: A tertiary referral centre. PATIENTS: Five patients (age 0.6 to 13 years; two female) were identified with an aortic root abscess. Four had no known pre-existing congenital heart abnormality. Three had a misleading presentation and were referred to our hospital with non-cardiac diagnoses (fulminant hepatic failure; adult respiratory distress syndrome; cerebrovascular accident). The other two presented with septicaemia and a murmur, respectively. Blood cultures identified Staphylococcus aureus (n = 3) and Streptococcus pneumoniae (n = 2). Aortic root abscess was diagnosed by transthoracic echocardiography. INTERVENTIONS: Homograft aortic root replacement with coronary reimplantation was performed urgently (median one day after diagnosis). RESULTS: Four patients survived. The youngest died following multiorgan failure, multiple aortic fistulae, three valve involvement, and extensive tissue destruction preventing mitral valve replacement (S pneumoniae). Two of the four survivors have required further surgery: mitral valve replacement (0.3 years later), and pulmonary autograft replacement of the homograft (8.3 years later). All survivors remain in sinus rhythm and New York Heart Association functional class I. CONCLUSIONS: Infective endocarditis should be considered in any child with severe septicaemia or embolic phenomena. Echocardiographic diagnosis of an aortic root abscess indicates uncontrolled infection and impending haemodynamic collapse. Homograft aortic root replacement can be performed successfully in critically ill children with active infection.  (+info)

Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
Cardiopulmonary bypass (CPB) induces hemodilutional anemia, which frequently requires the transfusion of blood products. The objective of this study was to evaluate oxygen delivery and consumption and clinical outcome in low risk patients who were allocated to an hematocrit (Hct) of 20% versus 25% during normothermic CPB for elective coronary artery bypass graft (CABG) surgery. This study was a prospective, randomized and controlled trial. Patients were subjected to normothermic CPB (35 to 36°C) and were observed until discharge from the intensive care unit (ICU). Outcome measures were calculated whole body oxygen delivery, oxygen consumption and clinical outcome. A nonparametric multivariate analysis of variance for repeated measurements and small sample sizes was performed. In a total of 54 patients (25% Hct, n = 28; 20% Hct, n = 26), calculated oxygen delivery (p = 0.11), oxygen consumption (p = 0.06) and blood lactate (p = 0.60) were not significantly different between groups. Clinical outcomes
TY - JOUR. T1 - Pulmonary perfusion with L-arginine ameliorates post-cardiopulmonary bypass lung injury in a rabbit model. AU - Chao, Yin Kai. AU - Wu, Yi Cheng. AU - Yang, Kun Ju. AU - Chiang, Ling Ling. AU - Liu, Hui Ping. AU - Lin, Pyng Jing. AU - Chu, Yen. PY - 2011/5/15. Y1 - 2011/5/15. N2 - Background: Post-cardiopulmonary bypass (CPB) lung injury is the combination of whole body inflammatory response and local ischemia-reperfusion (IR) injury. We investigated the benefit of pulmonary perfusion with L-arginine in protection against post-CPB lung injury. Methods: New Zealand white rabbits (n = 50, weight, 2.5-2.8 kg) were divided into five groups (n = 10 each): sham (sham sternotomy), CPB (CPB without pulmonary perfusion), perfusion (CPB with pulmonary perfusion), L-arginine (CPB with perfusion + L-arginine), and L-NAME (CPB with perfusion + L-NAME). The duration of CPB was 60 min followed by 2 h of reperfusion. Pulmonary perfusion was performed every 20 min through the pulmonary artery ...
TY - JOUR. T1 - Phenylephrine increases cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwariz, Arthur E.. AU - Minanov, Oktavijan. AU - Stone, J. Gilbert. AU - Adams, David C.. AU - Sandhu, Aqeel A.. AU - Pearson, Mark E.. AU - Kwiatkowski, Pawel. AU - Young, William L.. AU - Michler, Robert E.. PY - 1996/8/23. Y1 - 1996/8/23. N2 - Background: Although low-flow cardiopulmonary bypass (CPB) has become a preferred technique for the surgical repair of complex cardiac lesions in children, the relative hypotension and decrease in cerebral blood flow (CBF) associated with low flow may contribute to the occurrence of postoperative neurologic injury. Therefore, it was determined whether phenylephrine administered to increase arterial blood pressure during low-flow CPB increases CBF. Methods: Cardiopulmonary bypass was initiated in seven baboons during fentanyl, midazolam, and isoflurane anesthesia. Animals were cooled at a pump flow rate of 2.5 1 · min -1 · m ...
TY - JOUR. T1 - Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal piglet model. AU - Ündar, Akif. AU - Masai, Takafumi. AU - Yang, Shuang Qiang. AU - Eichstaedt, Harald C.. AU - McGarry, Mary Claire. AU - Vaughn, William K.. AU - Fraser, Charles D.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. Ten piglets underwent PP (n = 5) or NPP (n = 5). After initiation of CPB, all animals underwent 15 minutes of core cooling (25°C), 60 minutes of hypothermic CPB ...
TY - JOUR. T1 - Heparin-protamine balance after neonatal cardiopulmonary bypass surgery. AU - Peterson, J. A.. AU - Maroney, S. A.. AU - Zwifelhofer, W.. AU - Wood, J. P.. AU - Yan, K.. AU - Bercovitz, Rachel Sara. AU - Woods, R. K.. AU - Mast, A. E.. PY - 2018/10. Y1 - 2018/10. N2 - Essentials Heparin-protamine balance (HPB) modulates bleeding after neonatal cardiopulmonary bypass (CPB). HPB was examined in 44 neonates undergoing CPB. Post-operative bleeding occurred in 36% and heparin rebound in 73%. Thrombin-initiated fibrin clot kinetic assay and partial thromboplastin time best assessed HPB. Summary: Background Neonates undergoing cardiopulmonary bypass (CPB) are at risk of excessive bleeding. Blood is anticoagulated with heparin during CPB. Heparin activity is reversed with protamine at the end of CPB. Paradoxically, protamine also inhibits blood coagulation when it is dosed in excess of heparin. Objectives To evaluate heparin-protamine balance in neonates undergoing CPB by using research ...
TY - JOUR. T1 - Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwartz, A. E.. AU - Kaplon, R. J.. AU - Young, W. L.. AU - Sistino, J. J.. AU - Kwialkowski, P.. AU - Michler, R. E.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Background: Neurologic injury after cardiopulmonary bypass (CPB) is a frequent and devastating complication of cardiothoracic surgery. Disordered cerebral hemodynamics during CPB has been implicated as an important factor in the etiology of these injuries. Evidence of disordered cerebral hemodynamics includes reports of a progressive time-dependent decrease in cerebral blood flow (CBF) during stable full-flow CPB. Low-flow hypothermic CPB has become a preferred technique for the management of pediatric patients undergoing surgical repair of complex cardiac lesions. Because CBF is already substantially reduced with the onset of low-flow CPB, we determined if a similar progressive decline in CBF occurs during the low-flow state. Methods: After ...
TY - JOUR. T1 - Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. AU - Cziráki, Attila. AU - Ajtay, Zénó. AU - Németh, Ádám. AU - Lenkey, Zsófia. AU - Sulyok, Endre. AU - Szabados, Sándor. AU - Alotti, Nasri. AU - Martens-Lobenhoffer, Jens. AU - Szabó, Csaba. AU - Bode-Böger, Stefanie M.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization. Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n=20) or with off-pump CABG surgery (OPCABG; n=21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral ...
TY - JOUR. T1 - Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. AU - Andersen, K.. AU - Waaben, J.. AU - Husum, B.. AU - Voldby, B.. AU - Bødker, A.. AU - Hansen, A. J.. AU - Gjedde, A.. PY - 1985. Y1 - 1985. N2 - The effect of cardiopulmonary bypass on the relationship between brain glucose consumption and regional blood flow is unknown. We measured this relationship in pigs subjected to 3 hours of pulsatile or nonpulsatile cardiopulmonary bypass at normothermia and compared the results to the relationship established in a control group of pigs. A total of 10 regions were sampled in both hemispheres of the porcine brain. In control pigs, cerebral blood flow averaged 46 ml/100 gm and the glucose consumption, 21 μmol/100 gm/min. The ratio between blood flow and glucose consumption was close to 2 ml/μmol in all regions. In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, ...
Data & statistics on Carbon dioxide transfer rate in relation to cardiopulmonary bypass times: Carbon dioxide transfer rate in relation to cardiopulmonary bypass times, Shown in piglets undergoing deep hypothermic circulatory arrest (DHCA) with or without selective cerebral perfusion (SCP). Cerebral tissue oxygenation (Pbto2) is shown as relative units (RU), normalized to before cardiopulmonary bypass baseline (BL; mm Hg). Measurements are shown at the following times: BL, before cardiopulmonary bypass baseline; Cool, cooling; CA30, 30 minutes of DHCA; eCA, end DHCA; ..., Intraoperative SctO2 course of a patient undergoing aortic arch surgery with hypothermic circulatory arrest. Note dependency of SctO2 to CO2. Insufflation of CO2 during endoscopic vein harvesting leading to increase in SctO2 as well as decline in SctO2 once mechanical ventilation was started. CPB = cardiopulmonary bypass; DHCA = deep hypothermic circulatory arrest....
The major source of morbidity following cardiopulmonary bypass (CPB) is the systemic inflammatory response (SIRS response) which leads to multiple derangements in different organ systems. To combat this, miniaturized cardiopulmonary bypass circuits (MCPBC) have been created to lessen the inflammatory response to CPB. Here we examine early outcomes following coronary artery bypass grafting (CABG) using a MCPBC system compared to conventional bypass techniques at a single institution. Methods: 60 consecutive patients undergoing elective CABG were prospectively enrolled. Nine patients underwent coronary artery bypass grafting (CABG) with conventional CPB (cCABG), 33 underwent off-pump CABG (OPCAB), and the remaining 18 patients underwent CABG with a MCPBC system. Demographics and outcomes were compared between groups and statistical analyses applied. Results: No significant difference was observed in mortality between groups, with only one death reported in total. Morbidity was also low, totaling only 6.7%
Objective: We assessed the causes of imbalance of oxygen transport by continuously measuring oxygen consumption (VO2) during hypothermic cardiopulmonary bypass (CPB) in pigs. Methods: Six pigs (17.2±1.6 kg) underwent hypothermic (32°C) CPB for 180 min with 120 min of aortic crossclamping (ACC). An AMIS 2000 mass spectrometer was adapted for the on-line measurement of VO2. Arterial lactate was measured at the beginning of CPB, the end of hypothermia, before and 10 min after ACC release, 20 min later, and at the end of CPB. Results: Arterial lactate increased from 1.8±0.7 to 5.1±1.8 mmol/L during CPB. Hypothermia reduced VO2 by 0.63±0.29 ml/min/kg per °C, but lactate increased to 4.2±1.5 mmol/L ( ...
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Measurements and results: Subjects were observed for 24 hours; during surgery, 6 and 24 hours after aortic clamp removed. During July 2012 - December 2013, there were 52 patients who became subjects. There were proportion differences between cardiac lactate and cardiac output change after cardiac surgery. Increase of cardiac lactate has a correlation with increasing levels of sTNFR-1 and IL-6 and decreasing index of Tc, ScvO2 and cardiac output. There were correlations among low index of ScvO2, high index of cardiac lactate and decrease of cardiac output. High sTNFR-1 and IL-6 were correlated to low cardiac output. Cardiac lactate, ScvO2 and MAP can be used as predictors of cardiac output change in patients with cardio-pulmonary bypass. sTNFR-1 and IL-6 levels were correlated with cardiac output changes after cardiac surgery ...
Over a three year period we have used haemodialysis and haemofiltration in parallel with cardiopulmonary bypass in 26 patients. Impaired renal function and excessive fluid retention have been the main indications. Patients on haemodialysis programmes for end stage renal failure did not require further dialysis until at least the third postoperative day, when they could tolerate the haemodynamic disturbance of dialysis. In the other patients these techniques proved valuable in reversing the effects of haemodilution and in controlling the concentration of serum potassium. Our experience has confirmed that haemodialysis and haemofiltration in parallel with cardiopulmonary bypass are useful adjuncts in the perioperative management of patients with impaired renal function undergoing open heart surgery. The techniques are also effective in correcting the fluid retention and biochemical imbalance in patients with congestive cardiac failure, including those with heart transplants.. ...
Established as the standard reference on cardiopulmonary bypass, Dr. Gravlees text is now in its Third Edition. This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications. This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on circulatory support for minimally invasive cardiac surgery. Other highlights include state-of-the-art information on low-volume circuits and other new equipment and discussions of outcomes data for on-pump and off-pump surgeries ...
Acute kidney injury, a prevalent complication of cardiac surgery performed on cardiopulmonary bypass (CPB), is thought to be driven partly by hypoxic damage in the renal medulla. To determine the causes of medullary hypoxia during CPB, we modeled its impact on renal hemodynamics and function, and thus oxygen delivery and consumption in the renal medulla. The model incorporates autoregulation of renal blood flow and glomerular filtration rate and the utilization of oxygen for tubular transport. The model predicts that renal medullary oxygen delivery and consumption are reduced by a similar magnitude during the hypothermic (down to 28°C) phase of CPB. Thus, the fractional extraction of oxygen in the medulla, an index of hypoxia, is increased only by 58% from baseline. However, during the rewarming phase (up to 37°C), oxygen consumption by the medullary thick ascending limb increases 2.3-fold but medullary oxygen delivery increases only by 33%. Consequently, the fractional extraction of oxygen in ...
BACKGROUND: After cardiac surgery with cardiopulmonary bypass (CPB), acquired coagulopathy often leads to post-CPB bleeding. Though multifactorial in origin, this coagulopathy is often aggravated by deficient fibrinogen levels. OBJECTIVE: To assess whether laboratory and thrombelastometric testing on CPB can predict plasma fibrinogen immediately after CPB weaning. PATIENTS / METHODS: This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-CPB bleeding compares fibrinogen level (Clauss method) and function (fibrin-specific thrombelastometry) in order to study the predictability of their course early after termination of CPB. Linear regression analysis and receiver operating characteristics were used to determine correlations and predictive accuracy. RESULTS: Quantitative estimation of post-CPB Clauss fibrinogen from on-CPB fibrinogen was feasible with small bias (+0.19 g/l), but with poor precision and a percentage of error |30%. A clinically usefu
Summary. Background: Bleeding after cardiopulmonary bypass (CPB) is a major cause of morbidity and mortality and consumes large amounts of blood. Identifying patients at increased risk of bleeding secondary to hemostatic impairment may improve clinical outcomes by allowing early intervention. Methods: This present study recruited 77 patients undergoing CPB and measured coagulation screens, coagulation factors, TEG®, Rotem® and thrombin generation (TG) before surgery and 30 min after heparin reversal. The tests were analyzed to investigate whether they identified patients at increased risk of excess bleeding (defined as , 1000 mL) in the first 24 h postoperatively. Results: Patients who bled , 1000 mL had a lower: platelet count (P , 0.02), factors (F)IX, X and XI (P , 0.005), endogenous thrombin potential (ETP) and an initial rate of TG (P , 0.02) and higher activated partial thromboplastin time (aPTT) (P , 0.001) than patients who bled , 1000 mL. Receiver operating characteristic (ROC) ...
Click the title to purchase the article.. Abstract:. Femoro-femoral cardiopulmonary bypass (CPB) followed by deep hypothermic circulatory arrest is one of the modalities used for ascending aortic pseudoaneurysmrepair to achieve cardiac unloading and to avoid severe hemorrhage due to the risk of rupture during the sternal entry. However, due to the limited size of the cannulas, it can be challenging to achieve total cardiopulmonary support. Therefore, despite the achievement of total cardiopulmonary support, the heart may still be able to eject antegrade blood flow that meets the retrograde blood flow from the arterial side of the CPB. The point where the blood flow meets in the aorta is called the watershed area. If the antegrade blood flow is large due to a left ventricular ejection, the watershed area will be located in the descending aorta. Therefore, if ventilation is stopped, deoxygenated blood will be ejected to the cerebral circulation. Cerebral near-infrared spectroscopy (NIRS) may be ...
OBJECTIVE: The purpose of this study was to determine whether cognitive impairment is related to cardiopulmonary bypass. METHODS: Twenty-five patients undergoing coronary artery bypass grafting without cardiopulmonary bypass were matched with 50 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. All patients received the same anesthetic regimen, and one surgeon performed all the operations. A battery of 10 standard tests of neuropsychologic function were performed before, at discharge, and 3 months after the operation. A comprehensive multidimensional measure of subjective health status was used as the primary clinical measure of functional outcome. RESULTS: The groups were similar with respect to age, sex, and ventricular function and differed only in the need for a circumflex artery graft. Both groups showed significant improvement in the comprehensive multidimensional measure of subjective health status at 3 months. At discharge most neuropsychologic tests had
TY - JOUR. T1 - Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution. AU - Runge, T. M.. AU - McGinity, J. W.. AU - Frisbee, S. E.. AU - Briceno, J. C.. AU - Ottmers, S. E.. AU - Calhoon, John H. AU - Hantler, C. B.. AU - Korvick, D. L.. AU - Ybarra, J. R.. PY - 1997/5. Y1 - 1997/5. N2 - During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory. The incidence of the syndrome appears to be no less that 30% in patients over 65 years of age undergoing cardiac surgery. There are several factors contributing to hypoxia produced by cardiopulmonary bypass. One of these factors is crystalloid pump prime and replacement solutions devoid of (1) oxygen carrying capacity and (2) devoid of protein and its colloid osmotic pressure. This shortcoming of cardiopulmonary crystalloid solutions is partially responsible for two of the three major pathologic effects of ...
To the best of our knowledge, this is the first prospective study evaluating cognitive function before and after cardiopulmonary bypass in children. We found that the relatively short period of mildly hypothermic cardiopulmonary bypass was not associated with any change in cognitive function. The results of this study differ from the findings of a previous study that showed a 9.5-point deficit in full IQ and a deficit in nonverbal information processing in subjects who underwent surgical repair of an ASD compared with subjects who underwent ASD repair via a catheter-delivered device.15 Furthermore, although the previous study showed group differences in visual-spatial skills,15 we found no evidence to indicate that visual-spatial skills deteriorate after surgical repair of an ASD. Specifically, comparisons of nonverbal and spatial information processing in our sample suggest consistency of performance over time. In fact, a small increase was seen in the postoperative test scores. Although these ...
BACKGROUNDDiabetes mellitus is an independent risk factor for early postoperative mortality and complications after coronary artery bypass grafting (CABG). We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes.METHODS AND RESULTSTwenty atrial myocardium samples were harvested from 5 type II insulin-dependent diabetic and 5 matched nondiabetic patients undergoing CABG, before and after CPB/C. Oligonucleotide microarray analyses of 12625 genes were performed on the 10 sample pairs using matched pre-CPB tissues as controls. Array results were validated with Northern blotting and immunoblotting. Compared with pre-CPB/C, post-CPB/C myocardial tissues revealed 851 upregulated and 480 downregulated genes with a threshold P, or =0.025 (signal-to-noise ratio, 4.04) in the diabetic group, compared with 480 upregulated and 626 downregulated genes (signal-to-noise ratio, 3.04) in the nondiabetic group ...
During conventional cardiopulmonary bypass (CPB) there is no active perfusion of the pulmonary circulation and the mechanical ventilation is ceased leaving the lungs exposed to warm ischemia. Pulmonary dysfunction is seen in varying degrees after major surgery, but more severe in cardiac surgery patients probably due to the effects of CPB. The evidence for effect and safety are limited, but active pulmonary artery perfusion during CPB could be beneficial for the patients postoperative oxygenation. Our aim was in a randomised clinical trial to assess primarily the effect of pulmonary artery perfusion during CPB on postoperative oxygenation in patients diagnosed with chronic obstructive pulmonary disease (COPD), secondarily to assess other possible benefits and harms. Furthermore, we wanted in a systematic review with meta-analyses of all randomised clinical trials to investigate the pooled effects of pulmonary artery perfusion during CPB. We planned and conducted a randomised, partly blinded, ...
Michael Manning, MD, PhD, Research Fellow and Medical Instructor in the Division of Cardiothoracic Anesthesiology was awarded a two-year $50,000 Society of Cardiovascular Anesthesiologists (SCA) Starter Grant entitled Atrial Fibrillation Following Cardiopulmonary Bypass: The Role of Angiotensin II.. Post-operative atrial fibrillation (POAF) occurs in 30-60% of cardiac surgical patients, and is associated with increased morbidity and mortality. Preventative treatment options for this significant problem are lacking, with most therapy instituted after onset of POAF when associated risks, including stroke, are highest. Evidence suggests a key role for inflammation in the genesis and perpetuation of POAF through structural changes in the atrial wall; this may serve as a point for intervention and prevention, thereby decreasing overall morbidity and mortality.. Patients who undergo cardiac surgery with cardiopulmonary bypass (CPB) experience a significant inflammatory reaction, which has been ...
Epinephrine-induced lactic acidosis following cardiopulmonary bypass. Department of Intensive Care, Royal North Shore Hospital, St. Leonards, NSW, Australia. To determine if lactic acidosis occurring after cardiopulmonary bypass could be attributed to the metabolic or other effects of epinephrine administration. Posts
OBJECTIVES A meta-analysis was conducted to investigate the effects of ulinastatin treatment on adult patients undergoing cardiac surgery under cardiopulmonary bypass (CPB). METHODS Seven electronic databases were searched for reports of randomized, controlled trials conducted up to February 2014 in which patients undergoing cardiac surgery with CPB were administered ulinastatin in the perioperative period. RESULTS Fifty-two studies with 2025 patients were retained for analysis. The results showed that the ulinastatin can attenuate the plasma levels of pro-inflammatory cytokines and enhance the anti-inflammatory cytokine levels in patients undergoing cardiac surgery with CPB. Meanwhile, the ulinastatin had a significant beneficial effect on myocardial injury. The mean differences (MD) and 95% confidence intervals (95% CI) of biochemical markers were -63.54 (-79.36, -47.72) for lactate dehydrogenase, -224.99 (-304.83, -145.14) for creatine kinase, -8.75 (-14.23, -3.28) for creatine kinase-MB, and -0
Cardiac surgery with cardiopulmonary bypass (CPB) may cause inflammatory responses, which can deteriorate the outcomes. Inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6,-8 and -10, can act as both the effector and the predictor for post-operative inflammatory responses. Plasma mitochondrial DNA (mtDNA) was found as a pro-inflammatory agent recently, which was released when cells were insulted. In the present study, we included 38 patients undergoing coronary artery bypass graft (CABG) to analyze their perioperative plasma mtDNA and levels of inflammatory cytokines. Blood samples were collected before aortic cross-clamping (T1), at the end of CPB (T2), 6 h post-CPB (T3), 12 h post-CPB (T4), and 24 h post-CPB (T5). Rt-PCR and specific ELISA kits were used to quantify the plasma mtDNA and inflammatory cytokines, respectively. Bivariate correlations analysis was used to check the correlations between plasma mtDNA and inflammatory cytokines respectively. Results shown that
TY - JOUR. T1 - S100B increases in cyanotic versus noncyanotic infants undergoing heart surgery and cardiopulmonary bypass (CPB). AU - Varrica, Alessandro. AU - Satriano, Angela. AU - Gavilanes, Antonio D W. AU - Zimmermann, Luc J. AU - Vles, Hans J S. AU - Pluchinotta, Francesca. AU - Anastasia, Luigi. AU - Giamberti, Alessandro. AU - Baryshnikova, Ekaterina. AU - Gazzolo, Diego. PY - 2019/4. Y1 - 2019/4. N2 - AIMS: S100B has been proposed as a consolidated marker of brain damage in infants with congenital heart disease (CHD) undergoing cardiac surgery and cardiopulmonary bypass (CPB). The present study aimed to investigate whether S100B blood levels in the perioperative period differed in infants complicated or not by cyanotic CHD (CHDc) and correlated with oxygenation status (PaO2).METHODS: We conducted a case-control study of 48 CHD infants without pre-existing neurological disorders undergoing surgical repair and CPB. 24 infants were CHDc and 24 were CHD controls. Blood samples for S100B ...
The modern era of myocardial revascularization with cardiopulmonary bypass began in 1954 when Dr. John Gibbon reported the development of the cardiopulmonary bypass machine.6 An additional seminal advance occurred with the development of coronary angiography by Mason Sones at the Cleveland Clinic in 1957, which opened the door to the elective treatment of coronary atherosclerosis by means of direct revascularization.7 Initial reports by Rene Favaloro and Donald B. Effler on their techniques to treat clinical events associated with stenotic lesions of the coronary arteries culminated in the first large series of aorto-to-coronary artery venous grafts reported in 1969.8 Simultaneously Dudley Johnson of Milwaukee published a series of 301 patients in 1969.9 The success of these techniques was soon demonstrated in larger series initiating the modern era of coronary artery surgery. ...
This study is a multi-institutional randomized double-blind placebo controlled trial of the use of glucocorticoids to improve the clinical course of neonates following cardiac surgery. Cardiopulmonary bypass (CPB) is critical to cardiac surgery, but the pathophysiologic processes engendered by CPB play an important role in post-operative recovery. The use, doses and schedule of glucocortiocoid administration to ameliorate these CPB induced processes is highly variable and without clear data to provide direction. The Primary Aim of this study is to compare the effects of intraoperative methylprednisolone to placebo on a composite morbidity-mortality outcome following neonatal CPB. Secondary Endpoints include: inotropic requirements, incidence of low cardiac output syndrome, fluid balance, ICU stay parameters, levels of inflammatory molecules, neuro-developmental outcomes, and safety parameters. The study will focus on neonates because their post-CPB clinical course is typically more severe, and ...
Studio Mouth-to-mouth: An obstacle to cardio-pulmonary resuscitation for lay-rescuers pubblicato come Lettera allEditore su Resuscitation sul numero di Dicembre 2014.. Riferimento bibliografico:. E. Baldi, D. Bertaia, S.Savastano Mouth-to-mouth: An obstacle to cardio-pulmonary resuscitation for lay-rescuers Resuscitation. 2014 Dec;85(12):e195-6. ...
xml version=1.0?,,rfc1807,,datestamp,2018-06-04T14:57:38.6619335,/datestamp,,bib-version,v2,/bib-version,,id,39473,/id,,entry,2018-04-18,/entry,,title,Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes,/title,,swanseaauthors,,author,,sid,f5da81cd18adfdedb2ccb845bddc12f7,/sid,,ORCID,0000-0002-6986-6449,/ORCID,,firstname,Richard,/firstname,,surname,Bracken,/surname,,name,Richard Bracken,/name,,active,true,/active,,ethesisStudent,false,/ethesisStudent,,/author,,/swanseaauthors,,date,2018-04-18,/date,,deptcode,STSC,/deptcode,,abstract,IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ...
The cardio-pulmonary therapy staff provides services for children who have problems with the heart or lungs. Cardio-pulmonary therapy highlights:
The average salary for a Cardio-Pulmonary Perfusionist is $123,776. Visit PayScale to research cardio-pulmonary perfusionist salaries by city, experience, skill, employer and more.
Website. Interests: The effect of venodilation-based constant preload volume loading on hemodynamic variability in surgical patients. Crisis Management and Team Training for hospital-based resuscitation.Mechanism of radial arterial pressure changes following cardiopulmonary bypass. ...
Lacza, Zsombor and Csordás, Attila and Horváth, Eszter Mária and Pankotai, Eszter and Szabó, Csaba (2009) Mitokondriális eredetű nitrogén szabadgyökök és ATP-függő K-csatornák szerepe az organellum működésében = The involvement of mitochondrial-derived nitrogen radicals and mitoK-ATP channels in the regulation of organelle function. Project Report. OTKA. Rőth, Erzsébet and Alotti, Nasri and Lantos, János and Csordás, Attila and Papp, Lajos (1999) Oxidative stress following cardiopulmonary bypass. Journal of Molecular and Cellular Cardiology, 31. A56. ISSN 0022-2828 ...
The most common neurological deficits in children after surgery for congenital heart disease are fine and gross motor deficits. Recent magnetic resonance imaging studies have demonstrated a significant number of newly developed white matter (WM) lesions in infants after surgery. The present study describes region-specific WM development in the juvenile porcine brain, which is similar in developmental stage to the human newborn. Acute and long-term cellular responses to cardiopulmonary bypass in oligodendrocyte lineages and neuron-axonal elements, which are the most prominent cell populations in WM, have been observed. A uniquely susceptible cellular target of cardiopulmonary bypass-induced WM injury in the oligodendrocyte lineage, as well as maturation-dependent vulnerability of developing WM, was found. Oligodendrocyte progenitor cells, which mediate WM recovery function, are highly resistant to cardiopulmonary bypass-induced injury. Interestingly, oligodendrocyte progenitor cell number ...
The significance of acanthrocytes and red cell fragmentation was evaluated in 31 patients undergoing cardiopulmonary bypass. Seven patients served as controls, and 24 patients with valvular prosthesis were observed for a period of at least 2 weeks. In the control group minimal red cell fragmentation (2-3/10 hpf) was seen, while acanthrocytes were present only during and immediately after cardiopulmonary bypass. In seven patients with valvular replacement the results were similar to the control group. Six other patients showed increased red cell fragmentation (15/10 hpf). In three of these, red cell fragmentation disappeared by the third postoperative week, in two by ...
OBJECTIVE To investigate whether generation and liberation of bradykinin and histamine contribute to generalized edema formation in pediatric cardiopulmonary bypass surgery. DESIGN Prospective observational study. SETTING Pediatric heart surgery of a university hospital. PATIENTS Forty-one neonates, infants, and children undergoing cardiopulmonary bypass to correct congenital cardiac anomalies. INTERVENTIONS Plasma concentrations of bradykinin and histamine were determined before, during, and after cardiopulmonary bypass. Fluid balance was evaluated by control of fluid intake and output. MEASUREMENTS AND MAIN RESULTS The susceptibility to generalized edema formation increased significantly (r = -.457; p |.005) with decreasing age. Approximately three times higher plasma concentrations of bradykinin (p |.001) were found at the onset of anesthesia and during the total observation period in patients with a fluid retention of |6% of body weight compared with patients with a lower retention rate.
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient’s life by providing an appropriate blood flow and oxygen supply to principal organs. On the other hand, systemic inflammatory responses in patients undergoing cardiovascular surgery supported by CPB contribute significantly to CPB-associated mortality and morbidity. Our previous research showed that CPB causes a systemic inflammatory response and organ damage in a small animal CPB model. We have been studying the effects of hyperoxia and blood plasma substitute on CPB. In this review, we present a study focusing on the systemic inflammatory response during CPB, along with our findings.
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Coronary artery bypass grafting with extracorporal circulation is established as the golden standard. The conventional cardiopulmonary bypass (CPB) system is associated with inflammatory reaction, hemolysis, hemodilution an disturbances of the blood coagulation system. Also its well known that neurological disturbances caused by embolic material and air bubbles are potential risks of CPB. The new minimized perfusion circuit ROCsafeTM is a closed, reservoir-less, reduced prime, surface coated circuit, with optimized safety features in effectively eliminate both macro and micro air bubbles and should optimize the clinical outcome after CABG using cardiopulmonary bypass. ...
A countrys healthcare needs change over time, and as our population gets older, its healthcare needs become more complex.1 Nothing demonstrates this more than the increase seen in recent years in the number of cardiac surgeries. There are now more than one million cardiac surgeries annually across the world, and it is likely that this number will continue to rise.2. Cardiopulmonary Bypass (CPB) is a technique that temporarily takes over heart and lung function during surgery, maintaining the circulation and oxygenation of the patients blood.. Whilst patients are on Cardiopulmonary Bypass, they are most vulnerable and highly dependent on the skill of the clinical team and the technology that assists that team. During a typical cardiac surgery using Cardiopulmonary Bypass, patients will undergo a high number of tests, such as haemoglobin, haematocrit, blood gases and electrolytes. From induction of anesthesia until the immediate post-operative period, patients will typically have their blood ...
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Koşuyolu Kalp Dergisi, Kosuyolu Heart Journal, Increased Remnant Cholesterol Blood Concentration Associated with First Acute Coronary Syndrome, Negative Correlation Between Body Mass Index and Chest Tube Out-put After Coronary Artery Bypass Graft Surgery, Relation Between Cerebral Perfusion Changes and Mortality Scores During Cardiopulmonary Bypass at Adult Cardiac Surgery, Effect of Pulmonary Function Tests on Mortality and Morbidity Associated with Open Heart Surgery Performed with Cardiopulmonary Bypass, Education of Perfusionists in Turkey, Decreased Arterial Elasticity Assessed by Pulse Wave Velocity in Patients with Behçets Disease, Assessment of the Relationship Between C-Reactive Protein to Albumin Ratio and New-Onset Atrial Fibrillation in Patients with ST Elevation Myocardial Infarction, Reproducibility of Tilt-Table Test Potentiated with Double Dose Sublingual Nitroglycerin in Patients with Suspected Recurrent Syncopal Episodes, Impact of Left Ventricular Mass Index on Early Outcomes After
To the Editor, The impact of nitric oxide (NO) on renal function in critically ill patients is controversial. A broadly inclusive meta-analysis by Ruan et al. demonstrated a worsened renal function with NO therapy in acute respiratory distress syndrome (ARDS) patients whereas no clinically significant effect was outlined in non-ARDS subset, signifying that the effect of NO on kidney might be specific to the underlying pathophysiology[1].. It is noteworthy that two studies included in the aforementioned meta-analysis were contemplated in cardiac surgical patients, wherein post-cardiopulmonary bypass (CPB) NO administration did not incur an elevated risk of acute kidney injury (AKI)[1,2]. Interestingly, Lei et al. were the first group to delineate a renoprotective potential of NO in their randomized controlled trial (RCT) on 244 patients undergoing valve replacement surgeries. A peculiar characteristic of their study was the administration of 80 parts per million NO (via gas exchanger) on CPB ...
TY - JOUR. T1 - Profound hypothermia and cardiopulmonary bypass in the treatment of recurrent giant angioblastic meningioma - Case report. AU - Chung, Yong Gu. AU - Lee, Ki Chan. AU - Lee, In Sung. AU - Lee, Nam Jun. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1996/10. Y1 - 1996/10. N2 - Hypothermia and cardiopulmonary bypass has rarely been used for difficult lesions of the brain such as giant aneurysms and hemangioblastoma of the brainstem. We report a case of huge recurrent angioblastic meningioma operated under the profound hypothermia and cardiopulmonary bypass. We reviewed the complications related to hypothermia and cardiopulmonary bypass for brain lesions.. AB - Hypothermia and cardiopulmonary bypass has rarely been used for difficult lesions of the brain such as giant aneurysms and hemangioblastoma of the brainstem. We report a case of huge recurrent angioblastic meningioma operated under the profound hypothermia and cardiopulmonary bypass. We reviewed the ...
TY - JOUR. T1 - The Failure of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit to Reduce Blood Use after Cardiac Surgical Procedures. AU - Murphy, Glenn S.. AU - Szokol, Joseph W.. AU - Nitsun, Martin. AU - Alspach, David A.. AU - Avram, Michael J.. AU - Vender, Jeffery S.. AU - Votapka, Timothy V.. AU - Rosengart, Todd K.. PY - 2004/5. Y1 - 2004/5. N2 - Hemodilution during cardiopulmonary bypass (CPB) is a primary risk factor for blood transfusion in cardiac surgical patients. Priming of the CPB circuit with the patients own blood (retrograde autologous priming, RAP) is a technique used to limit hemodilution and reduce transfusion requirements. We designed this study to examine the impact of RAP on perioperative blood product use. Using a retrospective cohort study design, the medical records of all patients undergoing CPB (excluding circulatory arrest cases) by a single surgeon were examined. Data were collected over a 24-mo period when RAP was routinely used as a blood ...
Objective: The aim of this study was to investigate whether acute kidney injury (AKI) after coronary artery bypass grafting can be attributed to intraoperative hypotension during cardiopulmonary bypass (IOH-CPB). Design: Retrospective analysis. Setting: Tertiary-care hospital. Participants: Patients undergoing on-pump coronary artery bypass grafting from June 2011 to January 2014. Interventions: ... read more None. Measurements and Main Results: IOH-CPB was defined as blood pressure below several absolute and relative mean arterial pressure (MAP) thresholds and as the area under the curve for absolute MAP thresholds. AKI was defined as an absolute increase in serum creatinine of≥26 μmol/L within 48 hours or an increase to 150% or more within 7 days of surgery. Poisson regression with robust standard errors both before and after adjustment for confounders was used. Of the 1,891 patients included, 386 (20%) developed AKI. In univariable analysis, all IOH-CPB thresholds defined as a MAP of 50 ...
Cardiopulmonary bypass (CPB) is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the patients body. The CPB pump itself is often referred to as a heart-lung machine or the pump. Cardiopulmonary bypass pumps are operated by perfusionists. CPB is a form of extracorporeal circulation. Extracorporeal membrane oxygenation is generally used for longer-term treatment. Cardiopulmonary bypass is commonly used in coronary bypass heart surgery because of the difficulty of operating on the beating heart. Operations requiring the opening of the chambers of the heart require the use of CPB to support the circulation during that period. The machine pumps the blood, and, using an oxygenator, allows red blood cells to pick up oxygen, as well as allowing carbon dioxide levels to decrease. This mimics the function of the heart and the lungs, respectively. CPB can be used for the induction of total body ...
Background: Prolonged cross-clamp time during cardiac surgery increases the risk of postoperative mortality and myocardial injury. This subanalysis from the pexelizumab for reduction of infarction and mortality in coronary artery bypass grafting surgery (PRIMO-CABG) trial, a phase III double-blind, placebo-controlled study of 3,099 patients undergoing on-pump coronary artery bypass graft surgery with or without valve surgery, assessed the impact of pexelizumab, an investigational C5 complement inhibitor, on postoperative outcomes after prolonged aortic cross-clamp time. Methods: The composite endpoint of death or myocardial infarction through postoperative day 30 and death alone through days 30, 90, and 180 were examined in subpopulations of patients across different cross-clamp times. Results: After prolonged cross-clamping (≥90 minutes), death, or myocardial infarction through day 30 and death through days 30, 90, and 180 were significantly increased in the intent-to-treat population and ...
TY - JOUR. T1 - Microvascular perfusion and resistance in extracorporeal cardiopulmonary bypass under hypothermia with high-dose narcotic anesthesia--animal model.. AU - Huang, F. Y.. AU - Chen, Ta-Liang. AU - Fan, S. Z.. AU - Sun, W. Z.. PY - 1990/3. Y1 - 1990/3. N2 - Microvascular perfusion of the liver, kidney (cortex and medulla), pancreas and spleen was measured by laser-Doppler flowmetry under hypothermia in extracorporeal cardiopulmonary bypass, to determine the effectiveness of high-dose fentanyl in improving the microcirculation of these visceral organs. Twenty-four mongrel dogs in two groups were monitored by arterial catheter, Swan-Ganz catheter and laser-Doppler flowmeter. Cardiopulmonary bypass was carried out to induce hypothermia to 20 degrees C through the cannulation of inferior vena cava and aorta. Microvascular perfusion was measured by either needle or suturable probes of laser-Doppler flowmeter in liver, kidney (cortex and medulla), pancreas and spleen. With high-dose of ...
Nolan, J.P. et al. (2016) Critical Care.20(219) Background: In recent years there have been many developments in post-resuscitation care. We have investigated trends in patient characteristics and outcome following admission to UK critical care units following cardiopulmonary resuscitation (CPR) for the period 2004-2014. Our hypothesis is that there has been a reduction in risk-adjusted mortality during this…
A catheter system for use in minimally invasive cardiac surgical procedures. The catheter system diminishes certain trauma generally associated with invasive cardiac procedures while providing aortic occlusion, extracorporeal circulation, cardiac arrest, and cardiac venting. The catheter system provides a minimally invasive and simplified system that performs total cardiopulmonary bypass with ease of insertion, improved whole body profusion, and shortened recovery periods. The catheters are refined, with reduced diameters and specialized functions for maximum control of each aspect of cardiopulmonary bypass.
[115 Pages Report] Check for Discount on Global Cardio-pulmonary Exercise Testing Market Research Report 2016 report by QYResearch Group. Notes: Production, means the output of Cardio-pulmonary Exercise Testing...
Introduction Renal dysfunction is a significant variable in determining the outcome of surgery, such as cardiopulmonary bypass graft and valvular replacement, used to treat cardiovascular diseases. In Saudi Arabia, the incidence of renal failure and diabetes is higher than in most western populations. Our aim is to determine the renal outcome of patients who underwent cardiac surgery at King Faisal Cardiac Center from 2014 to 2017. Methods This a retrospective cohort study using a non-probability consecutive sampling technique for selection of the study population to assess the renal outcome in cardiac surgery patients using cardiopulmonary bypass from May 2014 to June 2017 in King Faisal Cardiac Center, Jeddah. Patients older than 18 years of age undergoing cardiac surgery, with available data, were included. Categorical variables were summarized by percentages and frequencies, and continuous variables by means and standard deviations, or medians and interquartile ranges if their distributions ...
We sought to assess the effects of cardiopulmonary bypass and profound hypothermic circulatory arrest on plasma cefazolin levels administered for antimicrobial prophylaxis in cardiovascular surgery.Four groups (10 patients per group) were prospectively studied: vascular surgery without cardiopulmonary bypass (group A), cardiac surgery with a cardiopulmonary bypass time of less than 120 minutes (group B), cardiac surgery with a cardiopulmonary bypass time of greater than 120 minutes (group C), and cardiac surgery with cardiopulmonary bypass and profound hypothermic circulatory arrest (group D). Subjects received cefazolin at induction and a second dose before wound closure. Arterial blood samples were obtained preceding cefazolin administration, at skin incision, hourly during the operation, and before redosing. Cefazolin plasma concentrations were determined by using a radial diffusion assay, with Staphylococcus aureus as the indicator microorganism. Cefazolin plasma concentrations were ...
TY - JOUR. T1 - Real time measurement of heparin concentration during cardiopulmonary bypass. AU - Hashimoto, Kazuhiro. AU - Sasaki, T.. AU - Hachiya, T.. AU - Takakura, H.. AU - Onoguchi, K.. AU - Nagahori, R.. AU - Takeuchi, S.. PY - 1999/10/1. Y1 - 1999/10/1. N2 - Background. A heparin/protamine titration system for measurement of heparin levels (Hepcon) is promising for efficient anticoagulation during cardiopulmonary bypass (CPB). Methods. Fifty-seven patients subjected to CPB were divided into two groups, control (n = 24) and Hepcon groups (n = 33). The Hepcon group was further divided into three subgroups according to perfusion temperature. For the control group, conventional administration of an anticoagulant (300 IU/kg of heparin) and reversal protocol (heparin 1: protamine 1) was performed. For the Hepcon group, a heparin dose-response assay directed the initial dose of heparin. Hepcon also determined the dose of protamine by the titration. The initial dose of heparin in the control ...
A series of studies from the Duke group have assessed the relationship between jugular venous desaturation and postoperative neuropsychologic outcome. [5-8] Their first report found no association. [5] Two subsequent reports, each derived from the same patient population, indicated that greater jugular venous hemoglobin desaturation at completion of rewarming (specifically, greater arteriovenous oxygen content difference) was associated with a greater incidence of postoperative cognitive deficits. [6,7] Of note, patients who exhibited marked jugular venous desaturation at completion of rewarming tended to have lesser CBF, greater cerebral metabolic rate for oxygen (CMRO2), and greater brain oxygen extraction before the start of rewarming. [6] This suggests patients who desaturated the most with rewarming differed from the rest of the study population before rewarming. Perhaps this preexisting difference was responsible for their greater postoperative cognitive impairment, not the jugular venous ...
Objective: The objective of the study is to compare the myocardial protective effects of isoflurane with propofol in patients undergoing elective coronary artery bypass surgery on cardiopulmonary bypass (CPB), the cardio protection been assessed by changes in N-terminal brain natriuretic peptide (NT proBNP). Methodology and Design: This study is designed as a participant blinded, prospective randomized clinical trial. Setting: Christian Medical College Hospital, Vellore, India. Participants: Patients undergoing elective coronary artery bypass surgery on CPB. Intervention: Anesthesia was maintained with 0.8-1.2 end tidal concentrations of isoflurane in the isoflurane group and in the propofol group, anesthesia was maintained with propofol infusion as described by Roberts et al. Measurements: Hemodynamic data were recorded at frequent intervals during the surgery and up to 24 h in the Intensive Care Unit (ICU). The other variables that were measured include duration of mechanical ventilation, dose ...
Early goal-directed therapy is a term used to describe the guidance of intravenous fluid and vasopressor/inotropic therapy by using cardiac output or similar parameters in the immediate post-cardiopulmonary bypass in cardiac surgery patients. Early recognition and therapy during this period may result in better outcome. In keeping with this aim in the cardiac surgery patients, we conducted the present study. The study included 30 patients of both sexes, with EuroSCORE ≥3 undergoing coronary artery bypass surgery under cardiopulmonary bypass. The patients were randomly divided into two groups, namely, control and early goal-directed therapy (EGDT) groups. All the subjects received standardized care; arterial pressure was monitored through radial artery, central venous pressure through a triple lumen in the right internal jugular vein, electrocardiogram, oxygen saturation, temperature, urine output per hour and frequent arterial blood gas analysis. In addition, cardiac index monitoring using ...
TY - JOUR. T1 - Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass. AU - Stevens, Louis Mathieu. AU - Fortier, Simon. AU - Aubin, Marie Claude. AU - El-Hamamsy, Ismail. AU - Maltais, Simon. AU - Carrier, Michel. AU - Perrault, Louis P.. PY - 2006/9/1. Y1 - 2006/9/1. N2 - Background: We hypothesized that cardiopulmonary bypass induces a selective alteration of the coronary arterial endothelial cell signal transduction which could be explained by a state of depletion and/or decreased activity of endogenous tetrahydrobiopterin (BH4). The aim of this study was to assess the effects of cardiopulmonary bypass and BH4 on the endothelial function of epicardial coronary arteries in a swine model of cardiopulmonary bypass. Methods: Swine underwent 90 min of cardiopulmonary bypass alone (N = 19) or in association with a brief cardioplegic arrest with (N = 6) or without (N = 5) in vivo BH4 administration, followed by a ...
PONTES, José Carlos D. V. et al. Comparative study of low-dose aprotinin x placebo during cardiopulmonary bypass. Rev Bras Cir Cardiovasc [online]. 2002, vol.17, n.1, pp.47-53. ISSN 0102-7638. http://dx.doi.org/10.1590/S0102-76382002000100008.. BACKGROUND: The use of aprotinin, a antifibrinolytic agent, has been shown to decrease damaging effects on cardiopulmonary bypass in fibrinolytic system, which may improve hemostasis. OBJECTIVE: To study the effect of low dose aprotinin in patients undergoing extracorporeal circulation. METHOD: Seventeen patients, underwent cardiopulmonary bypass to mitral valve replacement, was ramdomized in two groups: I (control) ¾ 9 patients received placebo after anesthesia induction and each hour in the priming; II (aprotinin) ¾ 8 patients received after anesthesia induction 30,000 KIU/kg and 7.500 KIU/kg each hour in the priming during the perfusion. The blood loss was observed through the first 24 hours postoperatively. Arterial blood samples were taken after ...
All information about the latest scientific publications of the Clínica Universidad de Navarra. Cardiopulmonary by-pass with cardiac arrest and deep hypothermia for the surgical treatment of tumor thrombi in the vena cava caused by kidney carcinoma
In contrast to the reports that did not show any deleterious effects of larger VTin patients with noninjured lungs, other articles have demonstrated the injurious effects of large VT.37-40Wrigge et al. 37reported on the effect of postoperative mechanical ventilation with lower VTon inflammatory responses induced by cardiopulmonary bypass surgery. In this study, immediately after surgery, mechanical ventilation was applied for 6 h with either VTof 6 or 12 ml/kg PBW. The time course of inflammatory mediators did not differ significantly between the ventilatory strategies, although in bronchoalveolar lavage fluid sampled after 6 h of initiation of mechanical ventilation, tumor necrosis factor α levels were significantly higher in patients ventilated with large VT. Similar results were found by Zupancich et al. , who randomly assigned elective coronary artery bypass patients to ventilation after surgery with large VT/low PEEP (10-12 ml/kg and 2-3 cm H2O) or low VT/high PEEP (8 ml/kg and 10 cm ...
Controversy on superiority of pulsatile versus non-pulsatile extracorporeal circulation in cardiac surgery still continues. Stroke as one of the major adverse events during cardiopulmonary bypass is, in the majority of cases, caused by mobilization o
Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (| 28 days of life) who underwent cardiac surgery under cardiopulmonary bypass (CPB), which have a high risk of nosocomial infection. In this pilot study, we studied nine neonates with a diagnosis of congenital heart disease requiring surgery under CPB. There was a significant reduction in monocyte HLA-DR expression for the first two postoperative days, as compared to preoperatively (p = 0.004). Moreover, neonates who displayed an episode of NI had a dramatically lower HLA-DR expression at day 4, as compared to neonates without NI (4257 AB/c [2220-5895] vs 14,947 AB/c [9858-16,960]; p = 0.04). Our preliminary results could indicate that HLA-DR expression may be a useful biomarker of immunosuppression-induced secondary infection after CPB in neonates.
A new Trasylol study is shedding more light on possible reasons behind the drug’s higher-than normal death rate. According to British researchers, while use of the clotting drug aprotininâ€known as Trasylolâ€appears safe during on-pump cardiac surgeries, it appears that combining it with angiotensin-converting enzyme inhibitorsâ€or ACE inhibitorsâ€during off-pump cardiac surgeries shows a significant risk of post-operative kidney dysfunction. Researchers analyzed 9,875 cardiac surgery patients, most of who (5,434) had on-pump cardiac surgery, meaning their hearts were stopped and they were hooked up to a heart-bypass machine during surgery. The other patients had off-pump cardiac surgery, in which surgeons operated on their beating hearts.. Trasylol is used to reduce perioperative blood loss and the need for blood transfusion in those patients undergoing cardiopulmonary bypass during coronary artery bypass graft ...
Methylene blue administration during cardio-pulmonary resuscitation and early reperfusion protects against cortical blood-brain barrier disruption: Objective: T
Agreements Between the Prothrombin Times of Blood Treated In Vitro with Heparinase During Cardiopulmonary Bypass (CPB) and Blood Sampled After CPB and Systemic Protamine Academic Article ...
TY - CHAP. T1 - Aprotinin and hemostasis in cardiopulmonary bypass. AU - Wildevuur, Ch.R.H.. AU - Eijsman, L.. AU - Hemker, H.C.. PY - 1995. Y1 - 1995. M3 - Chapter. SN - 1560531517. SP - 1. EP - 11. BT - Blood Conversation with Aprotinin. A2 - Pifarre, Roque. PB - Hanley and Belfus Inc.. CY - Philadelphia. ER - ...
Acute Kidney Injury (AKI) or Acute renal failure (ARF) is the temporary rapid breakdown of renal (kidney) function that occurs with high levels of uremic toxins (waste products of the bodys metabolism) accumulate in the blood. AKI occurs when the kidneys are unable to excrete (discharge) the daily load of toxins in the urine. Both kidneys are failing when Acute Kidney Injury (AKI) occurs. One normally functioning kidney can maintain adequate blood filtering. AKI affects approximately 1% of patients on admission to the hospital, 2% to 5% during the hospital stay, and 4% to 15% after cardiopulmonary bypass surgery. Based on the amount of urine that is excreted over a 24-hour period, patients with Acute Kidney Injury (AKI) are separated into two groups: Oliguric: patients who excrete less than 500 milliliters per day (, 16 oz/day) Nonoliguric: patients who excrete more than 500 milliliters per day (, 16 oz/day) In nonoliguric patients, the urine is of poor quality (i.e., contains little waste) ...
This study is investigating the pharmacokinetics of dexmedetomidine in paediatric patients undergoing cardiopulmonary bypass. The primary endpoints are
The incidence and temperature of onset of ventricular fibrillation in 132 patients having heart surgery performed using hypothermic cardiopulmonary bypass was determined.
Background: By lowering the oxygen fraction of the reperfusate, the reactive oxygen-derived free radicals can be reduced thus facilitating myocardial recovery during weaning from cardiopulmonary bypass and after surgery. Materials & Methods: Thirty patients undergoing mitral valve replacement were randomly exposed to an oxygen fraction of 0.7 (hyperoxic, n = 15) or 0.5 (normoxic, n = 15) during reperfusion. Hemodynamic variables, number of patients requiring additional inotropes and who developed new arrhythmia, duration of ventilation and intensive care unit stay, arterial blood gas and renal function were measured. Results: The demographic data, duration of cardiopulmonary bypass, aortic cross clamp time, duration of mechanical ventilation, intensive care unit stay, additional inotropes, arrhythmia after reperfusion and renal function were similar in both groups. Arterial blood gas analysis was not significantly different, except for the low oxygen partial pressure in the normoxic group during
Inventors and engineers tend to come up with ideas and technologies first, then say, This is cool, whats it good for? Clinicians tend to say, Heres my clinical problem, how can I solve it?. This was roughly the thinking that brought together Boston University engineer Pierre Dupont and Pedro del Nido, chief of Cardiac Surgery at Childrens Hospital Boston.. Dupont had a vision for a next-generation surgical robot. del Nido had a vision of doing complex cardiac repairs in children while their hearts are still beating. Could they create a viable technology?. Currently, there are two alternatives for fixing hearts. One is open-heart surgery: stop the heart, put the child on cardiopulmonary bypass, open the chest, and make the surgical repair. But theres risk - disruption of heart rhythm, infection, dangerous air bubbles slipping into the bloodstream, and possible inflammatory responses when the blood contacts the heart-lung machine. Recovery takes weeks to months.. Theres also ...
The research, conducted at the University of Michigans C.S. Mott Childrens Hospital and Boston Childrens Hospital, was published Online First in the New England Journal of Medicine Sept. 7.. Post-operative complications for infants and young children who have cardiac surgery remains common, so we want to identify risk factors that we can modify and interventions to help speed their recovery, says Michael G. Gaies, M.D., M.P.H., a physician in the Cardiac Intensive Care Unit at C.S. Mott, and senior author of the study.. Tight glycemic control using insulin was shown, in some studies, to improve outcomes in adult cardiac surgery patients, but we didnt know whether children would experience similar benefits.. The researchers studied 980 children from newborn to three years old who were undergoing surgery with cardiopulmonary bypass, representing the largest clinical trial ever performed in pediatric cardiac surgical patients. Patients either received standard cardiac intensive care or ...
Putting the basic science of reperfusion injury biology together with the need for better circulation of blood suggests a future direction for the treatment of the metabolic phase or intractable cardiac arrest. These new approaches are likely to work well in synergy with our proven therapies, such as early CPR, defibrillation, and percutaneous coronary intervention (PCI). To treat the complex metabolic dysfunction and high lethality of prolonged cardiac arrest, most experts are predicting an expansion of the use of invasive cardiopulmonary bypass in concert with drugs (likely several drugs combined together as a cocktail). The use of emergency cardiopulmonary bypass with the ability to produce nearly normal levels of blood flow is a logical extension of CPR but has only recently been shown to be practical for selected patients in emergency situations.92-96 Emergency cardiopulmonary bypass requires the placement of large cannula in a major artery and a major vein (typically femoral artery and ...
On multivariate analysis, previous sternotomy, aortic cross clamp time more than 45 min, cyanosis, emergency procedure were identified as independent predictors of early cardiac morbidity with respective odds ratios of 10.5, 3.7, 2.3 and 8.0. These four variables together could discriminate 77% of all procedures correctly as to their immediate post-operative morbidity. Taking the log odds with each of these 4 as the respective weights, a score was generated. The weights were previous sternotomy (2.4), aortic cross clamp , 45 min (1.3), emergency (2.1), cyanosis (0.8), if the respective condition is present, zero otherwise. The score ranged from 0 to 4.5.The average value of the score based on the 4 variables was significantly higher in cases with cardiac morbidity (0.75 ± 0.88) v/s (1.85 ± 1.17), p , 0.001. Distribution of the scores was significantly different between patients with and without morbidity. 67% patients without any morbidity had score , 1 compared to 24.6% with morbidity. Only ...
No cardiopulmonary bypass; instead, these procedures are performed on the normally beating heart. Few or no actual incisions ... These were performed epicardially, on the beating heart, without cardiopulmonary bypass or median sternotomy. Their method came ... without cardiopulmonary bypass. Until recently this was not thought possible; as recently as 2004, Dr. Cox defined the mini- ... and cardiopulmonary bypass (heart-lung machine; extracorporeal circulation). A series of improvements were made, culminating in ...
Cardiopulmonary bypass may be necessary. The internal mammary artery or saphenous vein can be used as grafts. The grafts are ... Cardiopulmonary bypass (CPB) / heart-lung machine: External pump to take over the function of both the heart and lungs. ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ... asystole is desired and induced during cardiopulmonary bypass through a cardioplegia solution containing very high amounts of ...
... to develop a less traumatic cardiopulmonary bypass technique. They also designed a miniaturized Cardiopulmonary Support circuit ... "Extracorporeal blood circuit for cardiopulmonary bypass US20110040229 A1". Google. Retrieved 5 December 2014. CS1 maint: ... "EXTRACORPOREAL BLOOD CIRCUIT FOR CARDIOPULMONARY BYPASS". Justia. Retrieved 12 December 2014. CS1 maint: discouraged parameter ... "Extracardiac Fontan operation without cardiopulmonary bypass". The Annals of Thoracic Surgery. 63 (4): 1175-7. doi:10.1016/ ...
"Historical development of cardiopulmonary bypass in Minnesota". In Glenn P. Gravlee (ed.). Cardiopulmonary Bypass: Principles ... A bubble oxygenator is an early implementation of the oxygenator used for cardiopulmonary bypass. It has since been supplanted ...
"Surgical myocardial revascularization without cardiopulmonary bypass". 69 (4). April 2000: 1216-1221. Cite journal requires , ... "Heart bypass surgery done on 20-month-old". Hindustan Times. 29 May 2009. "20-month-old undergoes bypass surgery". Deccan ... 3 Month Old Gets New Life After Heart Surgery - 12 May 2007 Heart Bypass Surgery Done on 20 Month Old - 29 May 2009 20 Month ... Thoracic and Thoraco-abdominal aortic aneurysms, mitral valve surgery and the beating heart Coronary Artery Bypass surgery. "Dr ...
"Intra-abdominal Complications of Cardiopulmonary Bypass Operations". Surgery Gynecology and Obstetrics. 165 (3): 251-254. PMID ... "Intra-abdominal Complications of Cardiopulmonary Bypass Operations". Surgery, Gynecology & Obstetrics. 165 (3): 251-254. PMID ... Taylor JD, Leitman IM, Hon P, Horowitz M, Panagopoulos G (2006). "Outcome and complications of gastric bypass surgery in super- ... "Is routine cholecystectomy necessary at the time of roux-en-y gastric bypass for morbid obesity?". Obesity Surgery. 16 (6): 759 ...
The cardiopulmonary bypass is then initiated by inserting a cannula into the ascending aorta as distally from the aortic root ... General anaesthesia and cardiopulmonary bypass are used. The aorta and pulmonary artery are detached from their native roots ... using the same method as would be used prior to bypass; however, there is a third opportunity for this still later in the ...
Current results with cardiopulmonary bypass". The Journal of Thoracic and Cardiovascular Surgery. 143 (1): 144-151. doi:10.1016 ...
The advent of cardiopulmonary bypass in the United States during the 1950s allowed the heart to be stopped for surgery without ... Cardiopulmonary bypass machines allow blood circulation and cooling to continue below the temperature at which the heart stops ... In 1959, using cardiopulmonary bypass (CPB), Barnes Woodhall and colleagues at Duke Medical Center performed the first brain ... Cardiopulmonary bypass machines were essential to the development of deep hypothermic circulatory arrest (DHCA) in humans. By ...
The patient is put on a cardiopulmonary bypass machine, also known as the heart-lung machine. This machine breathes for the ... Later, with the innovation of cardiopulmonary bypass, the ball valve prosthesis was placed orthotopically (i.e. in same place ... The patient is taken off the cardiopulmonary bypass machine. Transesophageal echocardiogram (an ultrasound of the heart done ... Once on cardiopulmonary bypass, the patient's heart is stopped (cardioplegia). This can be done with a Y-type cardioplegic ...
Michael DeBakey for blood transfusions while he was a medical student in 1932 and later used by him for cardiopulmonary bypass ... Passaroni, A. C; Silva, M. A; Yoshida, W. B (2015). "Cardiopulmonary bypass: Development of John Gibbon's heart-lung machine". ... using soft flat tubing was developed in 1992 for cardiopulmonary bypass systems. The first technically and commercially viable ... They are also used in heart-lung machines to circulate blood during a bypass surgery, and in hemodialysis systems, since the ...
May 1982). "Ischemic optic neuropathy: a complication of cardiopulmonary bypass surgery". Neurology. 32 (5): 560-2. doi:10.1212 ... Spine and cardiac bypass surgeries have the highest estimated incidences of PION, 0.028% and 0.018% respectively, and this is ...
"Percutaneous cannulation of the femoral vessels for cardiopulmonary bypass". Herz. 33 (5): 374-6. doi:10.1007/s00059-008-3043-2 ...
"Recent experiences with hexadimethrine for neutralizing heparin after cardiopulmonary bypass". Anaesthesia and Intensive Care. ...
An improved method of dealing with complications after cardiopulmonary bypass". The Journal of Thoracic and Cardiovascular ...
"Relative deficiency of arginine vasopressin in children after cardiopulmonary bypass". Critical Care Medicine. 38 (10): 2052-8 ... epinephrine alone in cardiopulmonary resuscitation". The New England Journal of Medicine. 359 (1): 21-30. doi:10.1056/ ... "A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation". The New England Journal of ... "Release of endogenous vasopressors during and after cardiopulmonary resuscitation". Heart. 75 (2): 145-50. doi:10.1136/hrt.75.2 ...
Misplaced Filter: Causes pericardiac tamponade requiring surgery under cardiopulmonary bypass. Filter Migration to Right Atrium ...
Yu, J; Xiao, YB; Wang, XY (2007). "Effects of preoperatively selected gut decontamination on cardiopulmonary bypass-induced ...
Direct transfusion is a blood salvaging method associated with cardiopulmonary bypass (CPB) circuits or other extracorporeal ... March 2012). "Changes in mechanical fragility and free hemoglobin levels after processing salvaged cardiopulmonary bypass ... "Comparison of three blood-processing techniques during and after cardiopulmonary bypass". Ann Thorac Surg. 56 (4): 938-43. doi: ... "Improved coagulation and blood conservation in the golden hours after cardiopulmonary bypass". J Extra Corpor Technol. 39 (2): ...
"Ventilation during Cardiopulmonary Bypass: Impact on Cytokine Response and Cardiopulmonary Function". Ann Thorac Surg. 85: 154- ...
Avoiding cardiopulmonary bypass". Urology. Elsevier BV. 66 (2): 266-270. doi:10.1016/j.urology.2005.03.039. ISSN 0090-4295. ... bypassing the need for a thoracoabdominal incision or cardiopulmonary bypass. In cases of known metastases, surgical resection ...
... the cardiopulmonary bypass is performed using a heart-lung machine (or cardiopulmonary bypass machine). The heart-lung machine ... All aspects of cardiopulmonary bypass, including manipulation of the aorta by the surgeon, may be associated with neurological ... Some hospitals use heparin-coated oxygenators for the large majority of their cases requiring cardiopulmonary bypass. It is ... 2001[full citation needed] examined the effects of heparin-coated cardiopulmonary bypass systems combined with full and low ...
"Pharmacokinetic analysis of flomoxef in children undergoing cardiopulmonary bypass and modified ultrafiltration". Gen Thorac ...
A variety of cannulas are used to establish cardiopulmonary bypass in cardiac surgery. A nasal cannula is a piece of plastic ...
He pioneered cardiopulmonary bypass to in patients with cardiac shock following myocardial infarction. After more than twenty ... He met with John Gibbon, the person who would later perfect cardiopulmonary bypass. In 1951, the first attempt with CPB was ... was an American cardiothoracic surgeon best known for his work in pioneering cardiopulmonary bypass (CPB). He had invented one ... of the first heart-lung bypass machines, and in 1951 he became the first to use such a device during an open-heart operation. ...
The Yasui procedure is done via a median sternotomy and uses cardiopulmonary bypass. If there is a patent ductus arterosus, the ... The Yasui procedure is a pediatric heart operation used to bypass the left ventricular outflow tract (LVOT) that combines the ...
Cardiopulmonary bypass is used if symptoms are refractory to treatment with these drugs. Successful use of charcoal ...
Mammary coronary artery anastomosis without cardiopulmonary bypass through minithoracotomy: one year clinical experience, and ... "Mammary coronary artery anastomosis without cardiopulmonary bypass through minithoracotomy: one year clinical experience" (PDF ...
"Mitral valve repair under cardiopulmonary bypass in small-breed dogs: 48 cases (2006-2009)". Journal of the American Veterinary ...
a) Surgical closure of a Perimembranous VSD is performed on cardiopulmonary bypass with ischemic arrest. Patients are usually ...
... quick anti-Xa-activity-based whole blood coagulation assay for monitoring unfractionated heparin during cardiopulmonary bypass ...
"Coagulopathy After Cardiopulmonary Bypass in Jehovah's Witness Patients: Management of Two Cases Using Fractionated Components ...
Cardiopulmonary bypass. *Cardioplegia. *Extracorporeal membrane oxygenation. *Vascular access. *Revascularization. *First rib ... Angioscopy is also used as an adjunctive procedure during vascular bypass to visualize valves within venous conduits. The ...
a b Dörges V, Sauer C, Ocker H, Wenzel V, Schmucker P. Smaller tidal volumes during cardiopulmonary resuscitation: comparison ... A bypass clip is usually incorporated into this valve assembly in case medical needs call for inflation at a pressure beyond ... Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation 2004: 109:1960-1965. *^ Lee HM, Cho KH, ... Part 8: Adult Advanced Cardiac Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and ...
"Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass" at ClinicalTrials.gov ... Pexelizumab is a drug designed to reduce side effects of coronary artery bypass grafting[1] and angioplasty,[2][3] among other ... report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft ...
"Silastic drains vs conventional chest tubes after coronary artery bypass". Chest. 124 (1): 108-13. doi:10.1378/chest.124.1.108 ... Cardiopulmonary resuscitation (CPR). *Mouth-to-mouth resuscitation. *Basic life support (BLS). *Advanced cardiac life support ( ...
Cardiopulmonary bypass (or any other surgeries requiring temporary aortic occlusion)[28]. *Heart failure[29] ... Lander H, Zammert M, FitzGerald D (September 2016). "Anticoagulation management during cross-clamping and bypass". Best ...
en:Cardiopulmonary bypass (26). *en:Caregiver (15). *en:Cataract surgery (13). *en:Cause of death (16) ...
... is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass. The presence of mannitol ... preserves renal function during the times of low blood flow and pressure, while the patient is on bypass. The solution prevents ...
Persistent free radicals connected to airborne fine particles are linked to cardiopulmonary disease.[16][17] ... should be permitted to bypass its government and deal directly with the European Commission regarding its air quality action ...
The Development of Cardiopulmonary Bypass. *^ Historical Heritage. *^ Frazier O.H. et al. "Cardiac Surgery in the Adult" Total ...
In cardiac surgery, both with and without cardiopulmonary bypass (e.g., coronary artery bypass surgery), it is used to prevent ...
... quick anti-Xa-activity-based whole blood coagulation assay for monitoring unfractionated heparin during cardiopulmonary bypass ...
"The Development of Cardiopulmonary Bypass". Archived February 3, 2007, at the Wayback Machine ctsnet.org. Retrieved: January 19 ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Cardiopulmonary bypass. *Cardioplegia. *Extracorporeal membrane oxygenation. *Vascular access. *Revascularization. *First rib ... An example is bypass surgery, where clogged blood vessels are bypassed with a graft from another part of the body. ...
For example, coronary artery bypass surgery (CABG), cardiopulmonary bypass and valve replacement are surgical procedures ... "Journal of Cardiopulmonary Rehabilitation and Prevention. 28 (6): 349-57. doi:10.1097/HCR.0b013e31818c3b96. PMC 2743684. PMID ... These two defects combined causes deoxygenated blood to bypass the lungs and going right back into the circulatory system. The ... This causes the deoxygenated blood to bypass the lungs and enter the circulatory system. Surgeries can fix this by redirecting ...
... recent editions of the American Heart Association's Guidelines for Cardiopulmonary Resuscitation have de-emphasized the role of ... developed a new technique for non-surgical orotracheal intubation to bypass laryngeal obstruction resulting from a diphtheria- ... "2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment ...
The heart and vessels are accessed via median sternotomy, and a cardiopulmonary bypass machine is used; as this machine needs ... in order for the red blood to bypass the lungs in utero, the fetal heart has two shunts that begin to close when the newborn ... circulation of a normal cardio-pulmonary system. Differences in the shape of the atrial septum and/or ventricular outflow ...
... coronary artery bypass surgery without the aforementioned cardiopulmonary bypass. In these operations, the heart is beating ... Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... The patient needs the function of the heart and lungs provided by an artificial method, hence the term cardiopulmonary bypass. ... In the long-run, pediatric cardiovascular surgery would rely on the cardiopulmonary bypass machine developed by Gibbon and ...
"Part 5: Adult Basic Life Support and Cardiopulmonary Resuscitation Quality - ECC Guidelines". eccguidelines.heart.org. ... Cricothyrotomy involves making an incision in a patient's neck and inserting a tube into the trachea in order to bypass the ... and other caregivers for children get training in choking first aid and cardiopulmonary resuscitation (CPR).[5] ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... This is the systemic circulation part of blood flow, the other loop of an interconnected normal cardio-pulmonary system. ...
輕微的失溫症可以用熱飲料、穿著暖和衣服及身體活動來改善。若是中等程
Effects of Mild Hypothermic Cardiopulmonary Bypass on Blood Viscoelasticity in Coronary Artery Bypass Grafting Patients, ... A. Ündar, W. Vaughn, and J. Calhoon, The effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on blood ... Strong correlations between blood viscoelasticity and regional and global cerebral blood flow during cardiopulmonary bypass ...
Heart/Lung bypass. *Urinary catheterization. *Dialysis. *Cardiopulmonary resuscitation. *Defibrillation. *Artificial pacemaker ... In the case of cardiac injuries, cardiopulmonary resuscitation is initiated by bystanders or family members 25% of the time. ...
a b c Deeper hypothermia is used, and survived, in cardiopulmonary bypass. ([1]) See also: Therapeutic hypothermia. ... she was connected to a cardiopulmonary bypass machine that warmed up her blood outside of her body[16][25] before it was ... began giving her cardiopulmonary resuscitation (CPR).[2] The rescue helicopter soon arrived and Bågenholm was brought to the ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... "Recovery of a hypothermic drowned child after resuscitation with cardiopulmonary bypass followed by prolonged extracorporeal ... Cardiopulmonary resuscitation (CPR) is an emergency procedure that combines chest compressions often with artificial ... July 2001). "Cardiopulmonary resuscitation performed by bystanders does not increase adverse effects as assessed by chest ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Cardiopulmonary resuscitation (CPR). *Care of the Critically Ill Surgical Patient (CCrISP). *First aid ...
This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on ... Established as the standard reference on cardiopulmonary bypass, Dr. Gravlees text is now in its Third Edition. This ... multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, ...
... Summary GlobalDatas Medical Devices sector report ... "Cardiopulmonary Bypass Equipment - Medical Devices Pipeline Assessment, 2016" provides an overview of Cardiopulmonary Bypass ... Cardiopulmonary Bypass Equipment - Medical Devices Pipeline Assessment, 2016. Friday, May 20, 2016 Medical Gadgets ... LONDON, May 19, 2016 /PRNewswire/ -- Cardiopulmonary Bypass Equipment - Medical Devices Pipeline Assessment, 2016Summary ...
The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a ... Cardiopulmonary bypass devices and methods. US20090018504 *. 20 Jun 2008. 15 Jan 2009. John Pile-Spellman. Systems and methods ... Peripheral cardiopulmonary bypass and coronary reperfusion system. US5069661 *. 18 May 1988. 3 Dec 1991. Brigham And Womens ... Cardiopulmonary bypass devices and methods. US9033298. 5 Apr 2012. 19 May 2015. Universitaetsklinikum Regensburg-Anstalt Des ...
Over a three year period we have used haemodialysis and haemofiltration in parallel with cardiopulmonary bypass in 26 patients ... Our experience has confirmed that haemodialysis and haemofiltration in parallel with cardiopulmonary bypass are useful adjuncts ...
Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 ... Acute renal injury is one of the most frequent complications after cardiopulmonary bypass (CPB). This study was designed to ...
Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patients life by providing an ... cardiopulmonary bypass systemic inflammation; cytokine; oxidative stress extracorporeal circulation; cardiopulmonary bypass ... Evaluation of Inflammation Caused by Cardiopulmonary Bypass in a Small Animal Model by Yutaka Fujii ... Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patients life by providing an ...
A comparison of retinal fluorescein angiograms taken before cardiopulmonary bypass with those taken just before the end of ...
Acanthrocytes and Schistocytes After Cardiopulmonary Bypass. Richard V. Smalley, M.D.; Felix M. Cortes, M.D., F.A.C.P. ... Acanthrocytes and Schistocytes After Cardiopulmonary Bypass.. Ann Intern Med. 1969;70:1086. doi: 10.7326/0003-4819-70-5-1086_2 ... The significance of acanthrocytes and red cell fragmentation was evaluated in 31 patients undergoing cardiopulmonary bypass. ... while acanthrocytes were present only during and immediately after cardiopulmonary bypass. In seven patients with valvular ...
Background: Bleeding after cardiopulmonary bypass (CPB) is a major cause of morbidity and mortality and consumes large amounts ... Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with ... Validation of viscoelastic coagulation tests during cardiopulmonary bypass, Journal of Thrombosis and Haemostasis, 2015, 13, 7 ... generation ex vivo using different haemostatic agents following cardiac surgery requiring the use of cardiopulmonary bypass, ...
Activation of Circulating Neutrophils in Patients following Cardiopulmonary Bypass. HA Jones, DNF Harris ... Activation of Circulating Neutrophils in Patients following Cardiopulmonary Bypass Message Subject (Your Name) has forwarded a ...
... and after cardiopulmonary bypass. Circulating platelets from 15 patients undergoing aorta-coronary bypass operations were ... and after cardiopulmonary bypass. Circulating platelets from 15 patients undergoing aorta-coronary bypass operations were ... Blood platelets in cardiopulmonary bypass operations. Recovery occurs after initial stimulation, rather than continual ... After the initial activation, platelet morphology began to recover although the bypass continued. During the late period of ...
Pumping Oxygenating Machine Cardiopulmonary bypass. Uses of cardiopulmonary bypass. Components of cardiopulmonary bypass. ... Cardiopulmonary Bypass. 1. Cardiopulmonary Bypass 2. Cardiac surgery*Coronary revascularisation (On and off pump) ... CARDIO PULMONARY BYPASS - CARDIO PULMONARY BYPASS ... circuit that functionally replaces heart and lung boldest and most ... Optimal perfusion during cardiopulmonary bypass: An Evidence-based approach - Optimal perfusion during cardiopulmonary bypass: ...
Glenn P Gravlee;] -- This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections ... patient safety in cardiopulmonary bypass -- Unusual problems in cardiopulmonary bypass -- Termination of cardiopulmonary bypass ... bypass> # Cardiopulmonary Bypass a schema:Intangible ;. schema:name "Cardiopulmonary Bypass"@en ;. . ... patient safety in cardiopulmonary bypass --. Unusual problems in cardiopulmonary bypass --. Termination of cardiopulmonary ...
Cardiopulmonary bypass (CPB) protocols of the baboon (Papio cynocephalus anubis) are limited to obtaining experimental data ... Pediatric cardiopulmonary bypass adaptations for long-term survival of baboons undergoing pulmonary artery replacement.. * ... Cardiopulmonary bypass (CPB) protocols of the baboon (Papio cynocephalus anubis) are limited to obtaining experimental data ...
Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis ... Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis ... Paparella, D., Yau, T. M., & Young, E. (2002). Cardiopulmonary bypass induced inflammation: Pathophysiology and treatment. An ...
Find cardiopulmonary bypass stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in ... cardiopulmonary bypass images. 378 cardiopulmonary bypass stock photos, vectors, and illustrations are available royalty-free. ... cannula surgerystamach operationcardiac care technologycardiopulmonary machineheart lung machinecardiac surgery professionals ...
Suction devices used to clear the field of debris and provide adequate venting during cardiopulmonary bypass and accessory ... Cannulae used to facilitate adequate myocardial protection to the heart during cardiopulmonary bypass. ... infants and small children requiring cardiopulmonary bypass at flow rates up to 2.0 L/min ... PBS Portable Bypass System. "Go anywhere" flexibility of the complete unit in the OR, ER, cathlab, or emergency transport ...
To compare cardiopulmonary bypass (CPB) with more conventional therapy in the treatment of severe amitriptyline poisoning. ... Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass.. Larkin GL1, ... Nine of ten swine treated with CPB were easily weaned off bypass without any pharmacologic intervention; however, one required ...
Emergency cardiopulmonary bypass under ongoing CPR. Emergency cardiopulmonary bypass (ECMO: lifebridge (Sorin®) or cardiohelp( ... Emergency Cardiopulmonary Bypass After Cardiac Arrest With Ongoing Cardiopulmonary Resuscitation - a Pilot Randomized Trial. ... Emergency Cardiopulmonary Bypass for Cardiac Arrest (ECPB4OHCA). The safety and scientific validity of this study is the ... Emergency cardiopulmonary bypass (ECPB - artificial heart and lung outside the patients body) is a method which has shown good ...
Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ... Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ... Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ...
Cardiopulmonary Bypass: Emerging Trends and Continued Practices, A. H. Stammers. Boston: Little, Brown, & Co., 1996, ISBN 0020- ... Home , February 1997 - Volume 84 - Issue 2 , Cardiopulmonary Bypass: Emerging Trends and Continued Practi... ... This monograph is a compendium of 12 subject areas related to cardiopulmonary bypass and was edited by a perfusionist with ... Cardiopulmonary Bypass: Emerging Trends and Continued Practices. Hensley, Frederick A. Jr., MD ...
Cardiopulmonary Bypass: A Primer was published by the cardiac surgery team at the University of Washington, using the iBook ... Cardiopulmonary Bypass: A Primer. University of Washington Division of Cardiothoracic Surgery. Nahush A. Mokadam, MD, Editor ... Watching the blood flow into and out of the cardiopulmonary bypass machine makes it "real" for the inexperienced reader. ... Although we are well aware of the techniques for establishing, maintaining, and discontinuing cardiopulmonary bypass, we ...
Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, ...
What is cardiopulmonary bypass? Meaning of cardiopulmonary bypass medical term. What does cardiopulmonary bypass mean? ... Looking for online definition of cardiopulmonary bypass in the Medical Dictionary? cardiopulmonary bypass explanation free. ... intestinal bypass (jejunoileal bypass) see intestinal bypass.. left heart bypass diversion of the flow of blood from the ... Related to cardiopulmonary bypass: cardioplegia. bypass. [bi´pas″] an auxiliary flow; a shunt; a surgically created pathway ...
Historical development of cardiopulmonary bypass. In: Gravlee GP, Davis RF, Utley JR, eds. Cardiopulmonary Bypass: principles ... THE ADVENT OF CARDIOPULMONARY BYPASS. In the 19th century, the interest of physiologists in the circulation of blood turned to ... BLOOD PUMPS FOR CARDIOPULMONARY BYPASS. The search for pumps capable of displacing large volumes of blood deserves its own ... COMPLICATIONS OF CARDIOPULMONARY BYPASS. Due to its mechanical components and their interaction with blood, CPB can produce ...
Hypoxaemia during Cardio-Pulmonary Bypass. A. L. Muir, I. A. Davidson. Clinical Science Jul 01, 1970, 39 (1) 4P; DOI: 10.1042/ ...
One of my surgeons had to put a patient on Cardiopulmonary Bypass for another... ... Does any one know if there is a CPT for Cardiopulmonary Bypass Support only? ... Does any one know if there is a CPT for Cardiopulmonary Bypass Support only? One of my surgeons had to put a patient on ... Did you ever find out if there is a separate code for cardiopulmonary bypass only? ...
... series on cardiopulmonary bypass in which he discusses some of the fundamental concepts underlying cardiopulmonary bypass and ... Ismail A, Miskolczi S, Ohri S. Southampton Reviews in Cardiothoracic Surgery Chapter Two: Cardiopulmonary Bypass. March 2019. ... Southampton Reviews in Cardiothoracic Surgery Chapter Two: Cardiopulmonary Bypass Friday, March 1, 2019 ... Percutaneous and Open Cannulation for Peripheral Cardiopulmonary Bypass: Pearls and Pitfalls * Cardiopulmonary Bypass: An ...
... as a vasodilator during cardiopulmonary bypass was assessed in consecutive adult patients (n = 24) who demonstrated a high ... Cardiopulmonary Bypass*. Coronary Artery Bypass. Endothelins / blood. Epinephrine / blood. Female. Heart Defects, Congenital / ... Administration of exogenous adenosine triphosphate (ATP) as a vasodilator during cardiopulmonary bypass was assessed in ... This study confirmed the efficacy and safety of ATP infusion during cardiopulmonary bypass.. ...
141 consecutive patients underwent cardiac surgery requiring cardiopulmonary bypass at our hospital. We measured ACT 3 minutes ... "Evaluation of a New Formula for Calculating Heparin Dose for Cardiopulmonary Bypass Patients" written by Aya Nakasuji, Satoshi ... An Adjusted Calculation Model of Reduced Heparin Doses in Cardiopulmonary Bypass Surgery in a Chinese Population. Journal of ... An Adjusted Calculation Model of Reduced Heparin Doses in Cardiopulmonary Bypass Surgery in a Chinese Population ...
Any patient undergoing elective (non-emergency) cardiopulmonary bypass for coronary artery bypass grafting, cardiac valve ... Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor. The safety and scientific ... Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor in the Perioperative Period. ... In previous studies, 90% of patients who underwent elective cardiopulmonary bypass procedure manifested CD4 counts of less than ...
Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy. Pappalardo, F.; Franco, A.; G., G. ... Cardiopulmonary bypass induces an ischaemia-reperfusion injury and systemic inflammatory response, which contributes to low ... Background: Accurate control of heparin anticoagulation is necessary during all stages of cardiopulmonary bypass (CPB). The ... Aprotinin protects the cerebral microcirculation during cardiopulmonary bypass. Ishibashi, N.; Iwata, Y.; Zurakowski, D.; Lidov ...
... provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for ... provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for ... Objectives In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) ... In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) ...
Cardiopulmonary bypass is associated with increases in gut permeability, which precede gut mucosal ischemia. In cardiac ... Conclusions: Cardiopulmonary bypass is associated with increases in gut permeability, which precede gut mucosal ischemia. In ... Intestinal permeability, gastric intramucosal pH, and systemic endotoxemia in patients undergoing cardiopulmonary bypass JAMA. ... and oxygen delivery in patients undergoing cardiopulmonary bypass (CPB). ...
Effects of Cardiopulmonary Bypass. Cardiopulmonary bypass (CPB) exposes neonates to harmful effects that are more pronounced ... Differences Between Adult and Pediatric Cardiopulmonary Bypass. Major differences adult and pediatric cardiopulmonary bypass ( ... Circulatory Arrest and Cardiopulmonary Bypass Hypothermia) and Circulatory Arrest and Cardiopulmonary Bypass Hypothermia What ... Circulatory Arrest and Cardiopulmonary Bypass Hypothermia. Updated: Feb 01, 2015 * Author: Bahaaldin Alsoufi, MD; Chief Editor ...
  • roviding cardiopulmonary bypass and surgical back-up for transcatheter aortic valve implantation has significant implications for surgical services. (bjcardio.co.uk)
  • The provision of cardiopulmonary bypass (CPB) equipment and cardiothoracic (CT) surgical back-up during transcatheter aortic valve implantation (TAVI) has major implications for surgical services. (bjcardio.co.uk)
  • Consensus statements from the Society of Cardiothoracic Surgery (SCTS) and the British Cardiovascular Intervention Society (BCIS) recommend that centres performing TAVI should have "immediate availability of perfusion services in case of the need for emergency bypass", and that this, together with other criteria, mean that TAVI should only be performed in units currently performing surgical aortic valve replacement. (bjcardio.co.uk)
  • METHODS: We used a unique rat model of cardiopulmonary bypass in which sternotomy, direct operations on the heart, aortic crossclamping, and cardioplegic arrest were not performed. (duke.edu)
  • BACKGROUND Diabetes mellitus is an independent risk factor for early postoperative mortality and complications after coronary artery bypass grafting (CABG). (scienceexchange.com)
  • Here we examine early outcomes following coronary artery bypass grafting (CABG) using a MCPBC system compared to conventional bypass techniques at a single institution. (gwu.edu)
  • Nine patients underwent coronary artery bypass grafting (CABG) with conventional CPB (cCABG), 33 underwent off-pump CABG (OPCAB), and the remaining 18 patients underwent CABG with a MCPBC system. (gwu.edu)
  • We conclude that nonpulsatile cardiopulmonary bypass at normothermia affects the metabolic flow regulation in the brain by interfering with the myogenic contractility of cerebral arterioles. (elsevier.com)
  • During cardiopulmonary bypass, blood pressure can be below the lower limit of cerebral autoregulation. (biomedcentral.com)
  • Although much debated, the constant blood flow provided by the cardiopulmonary bypass system is still considered by many as appropriate to avoid cerebral ischaemia despite the low blood pressure. (biomedcentral.com)
  • Diffusion-weighted magnetic resonance imaging (DWI) scans of a Perfusion Pressure Cerebral Infarct (PPCI) pilot study participant before ( a ) and after ( b ) heart surgery with the use of cardiopulmonary bypass (CPB). (biomedcentral.com)
  • During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory. (uthscsa.edu)
  • Pulmonary artery perfusion versus no pulmonary perfusion during cardiopulmonary bypass (Ph.d. (regionh.dk)
  • METHODS: Twenty-five patients undergoing coronary artery bypass grafting without cardiopulmonary bypass were matched with 50 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. (ox.ac.uk)
  • CONCLUSIONS: The similar pattern of early decline and late recovery of cognitive function in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass suggests that cardiopulmonary bypass is not the major cause of postoperative cognitive impairment. (ox.ac.uk)
  • This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on circulatory support for minimally invasive cardiac surgery. (platekompaniet.no)
  • Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient's life by providing an appropriate blood flow and oxygen supply to principal organs. (mdpi.com)
  • Experience with miniaturized cardiopulmonary bypass in cardiac surgery" by Dominic Emerson, Debbie Baldwin et al. (gwu.edu)
  • Background: Neurologic injury after cardiopulmonary bypass (CPB) is a frequent and devastating complication of cardiothoracic surgery. (elsevier.com)
  • Debilitating brain injury occurs in 1.6-5 % of patients undergoing cardiac surgery with cardiopulmonary bypass. (biomedcentral.com)
  • The trial is randomising 210 patients with coronary vessel and/or valve disease and who are undergoing cardiac surgery with the use of cardiopulmonary bypass. (biomedcentral.com)
  • OBJECTIVE: Cardiac surgery with cardiopulmonary bypass induces both systemic and local inflammatory responses implicated in the pathogenesis of myocardial dysfunction. (duke.edu)
  • AIMS: S100B has been proposed as a consolidated marker of brain damage in infants with congenital heart disease (CHD) undergoing cardiac surgery and cardiopulmonary bypass (CPB). (elsevier.com)
  • Acute kidney injury, a prevalent complication of cardiac surgery performed on cardiopulmonary bypass (CPB), is thought to be driven partly by hypoxic damage in the renal medulla. (edu.au)
  • A new study published in the journal Circulation suggests that infants who are undergoing cardiopulmonary bypass surgery may spend less time on a respirator if they receive thyroid supplementation. (endocrineweb.com)
  • This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications. (platekompaniet.no)
  • Prediction of Post-Weaning Fibrinogen Status during Cardiopulmonary Bypass: An Observational Study in 110 Patients. (unil.ch)
  • Summary: Background Neonates undergoing cardiopulmonary bypass (CPB) are at risk of excessive bleeding. (northwestern.edu)
  • Acute renal injury is one of the most frequent complications after cardiopulmonary bypass (CPB). (nih.gov)
  • Patients are stratified by age and surgical procedure and are randomised 1:1 to either an increased mean arterial pressure (70-80 mmHg) or 'usual practice' (40-50 mmHg) during cardiopulmonary bypass. (biomedcentral.com)
  • By using microarray technology, this study examines myocardial gene expression responses to cardiopulmonary bypass in the absence of cardioplegic arrest and ischemia-reperfusion injury. (duke.edu)
  • The cardiopulmonary bypass pump flow is fixed and set at 2.4 L/minute/m 2 body surface area plus 10-20 % in both groups. (biomedcentral.com)
  • Background: Post-cardiopulmonary bypass (CPB) lung injury is the combination of whole body inflammatory response and local ischemia-reperfusion (IR) injury. (elsevier.com)
  • During conventional cardiopulmonary bypass (CPB) there is no active perfusion of the pulmonary circulation and the mechanical ventilation is ceased leaving the lungs exposed to warm ischemia. (regionh.dk)
  • Essentials Heparin-protamine balance (HPB) modulates bleeding after neonatal cardiopulmonary bypass (CPB). (northwestern.edu)
  • Based on our preliminary observations, this mini-cardiopulmonary bypass circuit provides a safe alternative to conventional bypass techniques. (gwu.edu)
  • We found that bypass was available in the catheter lab in 94% of Edwards versus 30% of CoreValve centres (p=0.0003), and that a full surgical team and theatre were kept free in 89% of Edwards versus 20% of CoreValve centres (p=0.008). (bjcardio.co.uk)
  • RESULTS: Compared with sham-operated control animals, myocardium from animals undergoing cardiopulmonary bypass revealed 42 differentially expressed genes. (duke.edu)
  • Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. (scienceexchange.com)
  • We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes. (scienceexchange.com)
  • The ultrastructure of blood platelets was related to platelet function and secretion products before, during, and after cardiopulmonary bypass. (nih.gov)
  • After the initial activation, platelet morphology began to recover although the bypass continued. (nih.gov)
  • During the late period of bypass, a highly significant correlation between increasing plasma levels of alpha-granule compounds (platelet factor 4 and beta-thromboglobulin) and lysis parameters (lactic dehydrogenase and free hemoglobin) was found. (nih.gov)
  • In an inverse and probably causative manner, platelet morphology recovered, whereas the sensitivity of platelets to adenosine diphosphate and collagen decreased toward the end of bypass. (nih.gov)
  • In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, about 2 ml/μmol. (elsevier.com)
  • This is the first clinical randomised study to evaluate whether the mean arterial pressure level during cardiopulmonary bypass influences the development of brain injuries that are detected by diffusion-weighted magnetic resonance imaging. (biomedcentral.com)
  • To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery. (springer.com)
  • Pharmacodynamics of doxacurium during cardiac surgery with hypothermic cardiopulmonary bypass. (springer.com)
  • In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for congenital heart surgery. (frontiersin.org)
  • Increasingly complex repairs subsequently became possible with the refinement of cardiopulmonary bypass (CPB) techniques and the use of hypothermic circulatory arrest that Barratt-Boyes et al (1971) and Castaneda et al (1974) popularized. (medscape.com)
  • Hypothermic cardiopulmonary bypass. (scielo.br)
  • THERE is interest in the use of normothermic cardiopulmonary bypass in coronary artery bypass grafting (CABG) [1,2] because it is thought to offer better myocardial protection than standard hypothermic bypass. (asahq.org)
  • In a previous study we found that in each of six patients magnetic resonance (MR) images obtained within 1 h of the end of hypothermic bypass (immediate images) showed marked cerebral swelling that had returned to normal after 1 week. (asahq.org)
  • To determine the characteristics of neuromuscular block produced by two and three times the 95% effective dose (ED95) of doxacurium in patients undergoing coronary artery surgery with hypothermic cardiopulmonary bypass . (curehunter.com)
  • We propose to assess and compare the coupling of cerebral metabolism and cerebral blood flow in patients undergoing coronary artery bypass grafting using moderate hypothermic cardiopulmonary bypass primed with retrograde autologous or conventional priming. (isrctn.com)
  • Perfusion pressure control by adenosine triphosphate given during cardiopulmonary bypass. (biomedsearch.com)
  • Cells passing through the roller pumps are damaged and release free radicals, patients receive cerebral emboli (gaseous or solid), and bypass pump flow and pressure are set arbitrarily without knowledge of the perfusion needed by the individual patient. (asahq.org)
  • Effects of pulmonary perfusion during cardiopulmonary bypass on lung functions after cardiac operation. (degasperis.it)
  • Pulmonary artery perfusion during cardiopulmonary bypass (CPB) is a known but rarely used technique in adult cardiac surgery. (degasperis.it)
  • Consensus statements from the Society of Cardiothoracic Surgery (SCTS) and the British Cardiovascular Intervention Society (BCIS) recommend that centres performing TAVI should have "immediate availability of perfusion services in case of the need for emergency bypass", and that this, together with other criteria, mean that TAVI should only be performed in units currently performing surgical aortic valve replacement. (bjcardio.co.uk)
  • AA randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. (openanesthesia.org)
  • The editor, Dr. Nahush Mokadam , has structured the publication in a very logical format, with chapters describing the circuit components, technical aspects of cardiopulmonary support, myocardial protection, nursing principles, anesthesia management, troubleshooting, and finally a brief summary of the history of cardiopulmonary bypass. (ctsnet.org)
  • The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. (onlinejacc.org)
  • It is now well-established that AKI is a serious and common complication following cardiopulmonary bypass (CPB) in both children and adults, adverse outcomes may occur in the short term as well as long term, with higher incidence of chronic kidney disease, increased healthcare utilization and higher frequency of cardiovascular events in patients who develop post-CPB AKI. (frontiersin.org)
  • It is now well-established that AKI is a serious and common complication following cardiopulmonary bypass (CPB) in both children and adults, leading to worse outcomes and higher mortality ( 1 - 3 ). (frontiersin.org)
  • Postoperative cognitive dysfunction (POCD) is a common complication following cardiopulmonary bypass (CPB). (spandidos-publications.com)
  • The explanation of the inflammatory response to cardiopulmonary bypass summarizes a complex and controversial area. (lww.com)
  • A wide range of pharmacological, surgical, and mechanical pump approaches have been studied to attenuate the systemic inflammatory response to cardiopulmonary bypass, yet no systematically‐based review exists to cover the scope of anti‐inflammatory interventions deployed. (uwi.edu)
  • Global Cardiopulmonary Bypass Equipment Industry 2021 Market Research Report analysed the current state in the definitions, classifications, applications and industry chain structure. (beforeitsnews.com)
  • Global Cardiopulmonary Bypass Equipment Industry 2021 Market Research Report is a professionally prepared report comprising of in-depth information as well as knowledge which is helpful to the new entrants and the established players. (beforeitsnews.com)
  • Furthermore, each and every important variable which is responsible for shaping the Global Cardiopulmonary Bypass Equipment Industry in the incorporated during the preparation process of the report. (beforeitsnews.com)
  • Future Development Trends in the Global Cardiopulmonary Bypass Equipment Company through the market share, SWOT analysis, revenue, gross margin is indicated through the report. (beforeitsnews.com)
  • The competitive landscape of the market state showcases the study of the most renowned players in the China markets in the field of Global Cardiopulmonary Bypass Equipment industry. (beforeitsnews.com)
  • Through the report, the new entrants are able to get the complete overview of the current state of the Global Cardiopulmonary Bypass Equipment which will be beneficial for them. (beforeitsnews.com)
  • The Global Cardiopulmonary Bypass Equipment Market , by Product Type (Single Roller Pump and Double Roller Pump), By End User (Hospitals and Ambulatory Surgical Centers), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa), was valued at US$ 111.33 million in 2017 and is projected to exhibit a CAGR of 1.2% over the forecast period (2018 - 2026). (pharmiweb.com)
  • The global cardiopulmonary bypass equipment market growth is driven by rising incidence of cardiovascular and respiratory disorders. (pharmiweb.com)
  • The global cardiopulmonary bypass equipment market is expected to exhibit a CAGR of 1.2% during the forecast period (2018 - 2026). (pharmiweb.com)
  • Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease. (clinicaltrials.gov)
  • Complement and the damaging effects of cardiopulmonary bypass. (bmj.com)
  • Kirklin JK, Westaby S, Blackstone EH, et al: Complement and the damaging effects of cardiopulmonary bypass. (biomedcentral.com)
  • Several potent mediators are released into plasma, capable of causing harmful effects to different organs, contributing to postoperative morbidity after operations using cardiopulmonary bypass. (diva-portal.org)
  • BACKGROUND: Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion. (uzh.ch)
  • To provide a brief review of the development of cardiopulmonary bypass. (scielo.br)
  • Many of the studies conducted at this time laid the foundation for the future development of cardiopulmonary bypass (CPB). (scielo.br)
  • In the control group minimal red cell fragmentation (2-3/10 hpf) was seen, while acanthrocytes were present only during and immediately after cardiopulmonary bypass. (annals.org)
  • The Nellcor N-395 pulse oximeter failed more often immediately after cardiopulmonary bypass than did the Masimo SET Radical pulse oximeter. (ovid.com)
  • In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, about 2 ml/μmol. (elsevier.com)
  • Recent success using emergency percutaneous cardiopulmonary bypass as a tool for resuscitation from cardiac arrest is very encouraging. (nii.ac.jp)
  • Several studies-for example, the Evaluation of Patients During Coronary Artery Bypass Graft Operation: Linking Utilization of Bivalirudin to Improved Outcomes and New Anticoagulant Strategies (EVOLUTION-ON) and the Coronary Artery Bypass Grafting Heparin-Induced Thrombocytopenia Thrombosis Syndrome On- and Off-Pump Safety and Efficacy (CHOOSE-ON) trials-propose a reliable therapeutic protocol for bivalirudin. (medscape.com)
  • Single artery bypass of an occluded right coronary artery. (thefreedictionary.com)
  • aortocoronary bypass coronary artery bypass . (thefreedictionary.com)
  • Reston JT, Tregear SJ, Turkelson CM. Meta-analysis of short-term and mid-term outcomes following off-pump coronary artery bypass grafting. (medtronic.com)
  • Between October 1995 and Feburary 1997, 2 men and 4 women aged 53 to 75 years (mean, 66.3) underwent reoperative coronary artery bypass grafting without cardiopulmonary bypass. (springer.com)
  • Isolated reoperative circumflex or intermediate artery bypass was performed through a left thoracotomy (n=2), reoperative bypass to the left anterior descending coronary aretery was performed through a median sternotomy (n=3), and bypass to the right coronary artery was performed through an upper median laparotomy (n=1). (springer.com)
  • Reoperative coronary artery bypass grafting without cardiopulmonary bypass can be performed with low perioperative morbidity and mortality, easy postoperative management, satisfactory graft patency, and good symptomatic improvement. (springer.com)
  • Foster ED, Fisher LD, Kaiser GC, Myers WO: Comparison of operative mortality and morbidity for initial and repeat coronary artery bypass grafting. (springer.com)
  • Christenson JT, Bloch A, Marice J, Simonet F, Velevit V, Schmuziger M: Is reoperative coronary artery bypass grafting in patients with poor left ventricular ejection fractions ≤25% worth-while? (springer.com)
  • Moshkovitz Y, Lusky A, Mohr R: Coronary artery bypass without cardiopulmonary bypass. (springer.com)
  • Fanning WJ, Kakos GS, William TE Jr: Reoperative coronary artery bypass grafting without cardiopulmonary bypass. (springer.com)
  • Patients undergoing isolated coronary artery bypass grafting were sequentially randomized to conventional CPB (control group, n? (degasperis.it)
  • By avoiding cardiac arrest and cardiopulmonary bypass, it was hoped that complications seen after coronary artery bypass could be reduced. (cochrane.org)
  • Møller CH, Penninga L, Wetterslev J, Steinbrüchel DA, Gluud C. Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease. (cochrane.org)
  • This is due to the shift in trend towards the adoption of technologically advanced less invasive operating equipment, Off-Pump Coronary Artery Bypass (OPCAB) Beating Heart System. (pharmiweb.com)
  • A review of antiplatelet drugs, coronary artery diseases and cardiopulmonary bypass. (semanticscholar.org)
  • We investigated the influence of hydroxyethyl starch (HES) as a priming solution for the cardiopulmonary bypass (CPB) circuit on postoperative hemostasis in 45 patients undergoing elective coronary artery bypass grafting. (pptaglobal.org)
  • After local ethical committee approval, 20 patients undergoing coronary artery bypass grafting using CPB were prospectively randomly allocated to have either a Leukogard LG-6 (Pall Biomedical, Portsmouth, UK) or a nonleucocyte depleting filter inserted into the arterial line of the CPB circuit. (biomedcentral.com)
  • 20 Patients scheduled to undergo first time coronary artery bypass grafting will be recruited. (isrctn.com)
  • extra-anatomic bypass an arterial bypass that does not follow the normal anatomic pathway, such as an axillofemoral bypass. (thefreedictionary.com)
  • Methods: In 12 patients receiving coronary bypass grafts, arterial and coronary venous blood was obtained before onset of CPB, and 1, 5, 10, 25, 35 and 75 min after cardiac reperfusion. (uni-muenchen.de)
  • Single coronary bypass grafting utilizing arterial grafts (left internal thoracic artery: 3, right gastroepiploic artery: 3) was performed in all cases. (springer.com)
  • Arterial filter bypass loop: what occurs in this area during cardiopulmonary bypass and are there potential patient implications. (semanticscholar.org)
  • Arterial limb blood samples were taken immediately after institution of CPB (0min) and at 10-min intervals throughout the bypass period. (biomedcentral.com)
  • called also aortocoronary bypass . (thefreedictionary.com)
  • All patients had a primary elective aortocoronary bypass operation using standard anaesthetic techniques and no patient was withdrawn from the study. (bmj.com)
  • This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications. (worldcat.org)
  • Despite the constant evolution of cardiopulmonary bypass techniques and attempts to minimize their complications, it is still essential that clinicians respect the particularities of each patient's physiological function. (scielo.br)
  • Acute renal injury is one of the most frequent complications after cardiopulmonary bypass (CPB). (nih.gov)
  • Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass? (clinicaltrials.gov)
  • A Randomised, Double-Blind, Placebo-Controlled, Single-Centre Study of the Pre-Operative Effect of Sildenafil Citrate on Pulmonary Related Complications Following Cardiopulmonary Bypass in Children Undergoing Cardiac Surgical Repair. (clinicaltrials.gov)
  • [5] There are many opportunities for adverse complications to occur during bypass. (asahq.org)
  • Pediatric cardiopulmonary bypass adaptati. (mendeley.com)
  • Pediatric cardiopulmonary bypass adaptations for long-term survival of baboons undergoing pulmonary artery replacement. (mendeley.com)
  • The chapter on pediatric cardiopulmonary bypass is interesting and informative. (lww.com)
  • Major differences adult and pediatric cardiopulmonary bypass (CPB) stem from anatomic, metabolic, and physiologic differences in these 2 groups of patients. (medscape.com)
  • Jennifer K. Lee, R. Blaine Easley and Kenneth M. Brady, " Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass - Current and Future Directions", Current Cardiology Reviews (2008) 4: 123. (eurekaselect.com)
  • Median sternotomy for double lung transplantation with cardiopulmonary bypass in seven consecutive patients. (ebscohost.com)
  • We describe our technique of using median sternotomy to perform double lung transplantations with cardiopulmonary bypass. (ebscohost.com)
  • These were performed epicardially, on the beating heart, without cardiopulmonary bypass or median sternotomy. (wikipedia.org)
  • citation needed] Today, the terms "minimaze", "mini-maze", and "mini maze" are still sometimes used to describe open heart procedures requiring cardiopulmonary bypass and median sternotomy, but more commonly they refer to minimally invasive, epicardial procedures not requiring cardiopulmonary bypass, such as those developed by Saltman, Wolf, and others. (wikipedia.org)
  • [ 65 ] In a comparative analysis study of 10 patients undergoing cardiopulmonary bypass, three different methods of the ACT test were compared with ECT. (medscape.com)
  • A new cardiopulmonary bypass circuit with reduced foreign su. (lww.com)
  • The direct contact of the patient's blood with the foreign surface of the cardiopulmonary bypass (CPB) circuit plays an important role in triggering this response [1] . (lww.com)
  • In 19 patients with heparin-coated cardiopulmonary bypass equipment the levels were significantly reduced, indicating improved biocompatibility of the cardiopulmonary bypass circuit. (diva-portal.org)
  • Publications] Tajiri A, et al: 'A manually operated portable cardiopulmonary bypass circuit with two self inflating reservoir-pumps. (nii.ac.jp)
  • Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial. (ebscohost.com)
  • Fibrinogen concentrate supplementation during paediatric cardiopulmonary bypass may decrease the incidence and severity of postoperative bleeding, and reduce the need for transfusion of blood and ancillary blood products (platelets, fresh frozen plasma, and cryoprecipitate). (isrctn.com)
  • With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, there was a further rise in the already elevated concentrations of bradykinin. (ahajournals.org)
  • One minor weakness is the lack of a discussion of "normothermic" bypass in the chapter covering temperature management (this subject is addressed somewhat in the chapter on the neurologic effects of CPB). (asahq.org)
  • The chapter on renal considerations, dialysis, and ultrafiltration during bypass is also a nice general review of current practices in the cardiac operating room. (lww.com)
  • hepatorenal bypass insertion of a vascular prosthesis between the common hepatic artery and the renal artery, serving as a passage around an occluded segment of renal artery. (thefreedictionary.com)
  • Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 expression. (nih.gov)
  • Objective: To determine the optimal venous tubing diameter for adult cardiopulmonary bypass (CPB) to improve gravity drainage and to reduce priming volume. (rero.ch)
  • Cardiopulmonary Bypass: Principles and Practice , 3rd Edition, does an outstanding job of explaining both the mechanical and physiologic process of CPB. (asahq.org)
  • Buylaert WA, Herregods LL, Mortier EP, Bogaert MG . Cardiopulmonary bypass and the pharmacokinetics of drugs. (springer.com)
  • Following cardiopulmonary bypass (CPB), the incidence rates of short-term cognitive abnormalities, memory and learning ability decline and visual-motor response declines by 60-80% ( 1 ). (spandidos-publications.com)
  • In seven patients undergoing coronary bypass, heparin-coated circuits were used (group HC), and seven served as control patients (group C). In group HC the heparin dose was reduced to 75% (225 IU/kg). (diva-portal.org)