Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Surgery performed on the heart.
A technique to arrest the flow of blood by lowering BODY TEMPERATURE to about 20 degrees Centigrade, usually achieved by infusing chilled perfusate. The technique provides a bloodless surgical field for complex surgeries.
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Devices which mechanically oxygenate venous blood extracorporeally. They are used in combination with one or more pumps for maintaining circulation during open heart surgery and for assisting the circulation in patients seriously ill with some cardiac and pulmonary disorders. (UMDNS, 1999)
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
The period following a surgical operation.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
The constant checking on the state or condition of a patient during the course of a surgical operation (e.g., checking of vital signs).
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Elements of limited time intervals, contributing to particular results or situations.
The period during a surgical operation.
Making an incision in the STERNUM.
Coagulant substances inhibiting the anticoagulant action of heparin.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Application of heat to correct hypothermia, accidental or induced.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
Devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers. (Dorland, 28th ed)
Loss of blood during a surgical procedure.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
A long, narrow, and flat bone commonly known as BREASTBONE occurring in the midsection of the anterior thoracic segment or chest region, which stabilizes the rib cage and serves as the point of origin for several muscles that move the arms, head, and neck.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
Surgical insertion of synthetic material to repair injured or diseased heart valves.
Surgery performed on the heart or blood vessels.
Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
Apparatus that provides mechanical circulatory support during open-heart surgery, by passing the heart to facilitate surgery on the organ. The basic function of the machine is to oxygenate the body's venous supply of blood and then pump it back into the arterial system. The machine also provides intracardiac suction, filtration, and temperature control. Some of the more important components of these machines include pumps, oxygenators, temperature regulators, and filters. (UMDNS, 1999)
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The time required by whole blood to produce a visible clot.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
Counterpulsation in which a pumping unit synchronized with the patient's electrocardiogram rapidly fills a balloon in the aorta with helium or carbon dioxide in early diastole and evacuates the balloon at the onset of systole. As the balloon inflates, it raises aortic diastolic pressure, and as it deflates, it lowers aortic systolic pressure. The result is a decrease in left ventricular work and increased myocardial and peripheral perfusion.
Surgical incision into the chest wall.
Blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.
The act of constricting.
The measure of the level of heat of a human or animal.
Procedures that avoid use of open, invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
The period of confinement of a patient to a hospital or other health facility.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.
Rhythmic compression of the heart by pressure applied manually over the sternum (closed heart massage) or directly to the heart through an opening in the chest wall (open heart massage). It is done to reinstate and maintain circulation. (Dorland, 28th ed)
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
A surgical specialty concerned with diagnosis and treatment of disorders of the heart, lungs, and esophagus. Two major types of thoracic surgery are classified as pulmonary and cardiovascular.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
An abnormal balloon- or sac-like dilatation in the wall of AORTA.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The design or construction of objects greatly reduced in scale.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Interventions to provide care prior to, during, and immediately after surgery.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE.
Measurement of oxygen and carbon dioxide in the blood.
Operative procedures for the treatment of vascular disorders.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
The degree to which BLOOD VESSELS are not blocked or obstructed.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Pumping that aids the natural activity of the heart. (Dorland, 27th ed)
Antifibrinolytic hemostatic used in severe hemorrhage.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues using a transducer placed in the esophagus.
Control of bleeding during or after surgery.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
The vein which drains the foot and leg.
The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
Methods of creating machines and devices.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
General or unspecified injuries to the heart.
Ultrashort-acting anesthetics that are used for induction. Loss of consciousness is rapid and induction is pleasant, but there is no muscle relaxation and reflexes frequently are not reduced adequately. Repeated administration results in accumulation and prolongs the recovery time. Since these agents have little if any analgesic activity, they are seldom used alone except in brief minor procedures. (From AMA Drug Evaluations Annual, 1994, p174)
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
Developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects.
Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
The chambers of the heart, to which the BLOOD returns from the circulation.
Shock resulting from diminution of cardiac output in heart disease.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The blood pressure in the central large VEINS of the body. It is distinguished from peripheral venous pressure which occurs in an extremity.
The period before a surgical operation.
A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Method of measuring performance against established standards of best practice.
Cardiac electrical stimulators that apply brief high-voltage electroshocks to the HEART. These stimulators are used to restore normal rhythm and contractile function in hearts of patients who are experiencing VENTRICULAR FIBRILLATION or ventricular tachycardia (TACHYCARDIA, VENTRICULAR) that is not accompanied by a palpable PULSE. Some defibrillators may also be used to correct certain noncritical dysrhythmias (called synchronized defibrillation or CARDIOVERSION), using relatively low-level discharges synchronized to the patient's ECG waveform. (UMDNS, 2003)
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.
Plastic tubes used for drainage of air or fluid from the pleural space. Their surgical insertion is called tube thoracostomy.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
The circulation of the BLOOD through the LUNGS.
Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
A curare alkaloid that is a very potent competitive nicotinic antagonist at the neuromuscular junction.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
Procedure in which patients are induced into an unconscious state through use of various medications so that they do not feel pain during surgery.
Lower than normal body temperature, especially in warm-blooded animals.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
Surgery performed on the thoracic organs, most commonly the lungs and the heart.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological processes involving any part of the LUNG.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
Pathological processes involving any part of the AORTA.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Agents that prevent clotting.
Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)
The determination of oxygen-hemoglobin saturation of blood either by withdrawing a sample and passing it through a classical photoelectric oximeter or by electrodes attached to some translucent part of the body like finger, earlobe, or skin fold. It includes non-invasive oxygen monitoring by pulse oximetry.
An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
Services specifically designed, staffed, and equipped for the emergency care of patients.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
An infant during the first month after birth.
The valve between the left atrium and left ventricle of the heart.
An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
Obstruction of flow in biological or prosthetic vascular grafts.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Blocking of a blood vessel in the SKULL by an EMBOLUS which can be a blood clot (THROMBUS) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with HEART DISEASES. Other non-cardiac sources of emboli are usually associated with VASCULAR DISEASES.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Removal of an implanted therapeutic or prosthetic device.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Diversion of the flow of blood from the entrance to the right atrium directly to the pulmonary arteries, avoiding the right atrium and right ventricle (Dorland, 28th ed). This a permanent procedure often performed to bypass a congenitally deformed right atrium or right ventricle.
Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.
Situations or conditions requiring immediate intervention to avoid serious adverse results.
The natural enzymatic dissolution of FIBRIN.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
The flow of BLOOD through or around an organ or region of the body.
A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
An isoenzyme of creatine kinase found in the CARDIAC MUSCLE.
A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

Lamotrigine attenuates cortical glutamate release during global cerebral ischemia in pigs on cardiopulmonary bypass. (1/1874)

BACKGROUND: The dose-response effects of pretreatment with lamotrigine (a phenyltriazine derivative that inhibits neuronal glutamate release) in a porcine cerebral ischemia model during cardiopulmonary bypass were studied. METHODS: Sagittal sinus catheters and cortical microdialysis catheters were inserted into anesthetized pigs. Animals undergoing normothermic cardiopulmonary bypass were pretreated with lamotrigine 0, 10, 25, or 50 mg/kg (n = 10 per group). Fifteen minutes of global cerebral ischemia was produced, followed by 40 min of reperfusion and discontinuation of cardiopulmonary bypass. Cerebral oxygen metabolism was calculated using cerebral blood flow (radioactive microspheres) and arterial-venous oxygen content gradients. Concentrations of microdialysate glutamate and aspartate were quantified; electroencephalographic signals were recorded. After cardiopulmonary bypass, blood and cerebrospinal fluid were sampled for S-100B protein, and a biopsy was performed on the cerebral cortex for metabolic profile. RESULTS: Lamotrigine caused dose-dependent reductions in systemic vascular resistance so that additional fluid was required to maintain venous return. Concentrations of glutamate and aspartate did not change during reperfusion after 50 mg/kg lamotrigine in contrast to fivefold and twofold increases, respectively, with lower doses. There were no intergroup differences in cerebral metabolism, electroencephalographic scores, cortical metabolites, brain lactate, or S-100B protein concentrations in the cerebrospinal fluid and blood. CONCLUSIONS: Lamotrigine 50 mg/kg significantly attenuated excitatory neurotransmitter release during normothermic cerebral ischemia during cardiopulmonary bypass without improving other neurologic parameters. Lamotrigine caused arterial and venous dilation, which limits its clinical usefulness.  (+info)

Biventricular repair approach in ducto-dependent neonates with hypoplastic but morphologically normal left ventricle. (2/1874)

OBJECTIVES: Increased afterload and multilevel LV obstruction is constant. We assumed that restoration of normal loading conditions by relief of LV obstructions promotes its growth, provided that part of the cardiac output was preoperatively supported by the LV, whatever the echocardiographic indexes. BACKGROUND: Whether to perform uni- or biventricular repair in ducto dependent neonates with hypoplastic but morphologically normal LV (hypoplastic left heart syndrome classes II & III) remains unanswered. Echocardiographic criteria have been proposed for surgical decision. METHODS: Twenty ducto dependent neonates presented with this anomaly. All had aortic coarctation associated to multilevel LV obstruction. Preoperative echocardiographic assessment showed: mean EDLW of 12.4 +/- 3.03 ml/m2 and mean Rhodes score of -1.73 +/-0.8. Surgery consisted in relief of LV outflow tract obstruction by coarctation repair in all associated to aortic commissurotomy in one and ASD closure in 2. RESULTS: There were 3 early and 2 late deaths. Failure of biventricular repair and LV growth was obvious in patients with severe anatomic mitral stenosis. The other demonstrated growth of the left heart. At hospital discharge the EDLVV was 19.4+/-3.12 ml/m2 (p = 0.0001) and the Rhodes score was -0.38+/-1.01 (p = 0.0003). Actuarial survival and freedom from reoperation rates at 5 years were 72.5% and 46%, respectively. CONCLUSIONS: Biventricular repair can be proposed to ducto dependent neonates with hypoplastic but morphologically normal LV provided that all anatomical causes of LV obstruction can be relieved. Secondary growth of the left heart then occurs; however, the reoperation rate is high.  (+info)

Coronary sinus adrenomedullin rises in response to myocardial injury. (3/1874)

Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated levels of the cardiospecific protein troponin-T (Tn-T) during cardiopulmonary bypass. ADM (pg/ml) and Tn-T (ng/ml) were measured in coronary sinus blood before and after aortic cross-clamp and in venous blood 6 h after surgery in 22 coronary-bypass patients. Based on the pre- and post-clamp Tn-T levels in the coronary sinus, the patients were divided into group I (no change; n=10) and group II (two times increase; n=12). Baseline ADM (362.7+/-106.2 and 303+/-58.7 pg/ml in groups I and II respectively; means+/-S.D.) and Tn-T (0.66+/-0.14 and 0.57+/-0.13 ng/ml respectively) levels were similar in both groups. In group I, the post-clamp ADM (317.6+/-80.8 pg/ml) and Tn-T (0.68+/-0.15 ng/ml) levels did not change significantly. In group II, the post-clamp ADM levels rose significantly above the baseline, mimicking the change in Tn-T (ADM, 541.4+/-89.4 pg/ml; Tn-T, 1.37+/-0.31 ng/ml; P=0.009). After 6 h, the systemic Tn-T levels were similar in both groups (2. 09+/-0.44 and 1.95+/-0.52 ng/ml in groups I and II respectively). We suggest that: (1) minor degrees of myocardial ischaemic damage result in release of ADM by the heart, and (2) ADM may play a protective role in the myocardium during an ischaemic insult. This suggests a possible therapeutic role for ADM in the management of intra-operative myocardial ischaemia.  (+info)

Transitory cerebral microvascular blockade after cardiopulmonary bypass. (4/1874)

Dogs were submitted to cardiopulmonary bypass (CPB) carried out under conditions calculated to generate large numbers of microbubbles and microemboli. On the day following the procedure the dogs showed evidence of neurological damage including impaired consciousness and ataxia. These abnormalities largely cleared within a week. When the animals were sacrificed at intervals after the procedure, the cerebral microvasculature was demonstrated by injecting a suspension a lamp black into the carotid artery. This revealed that multiple filling defects were present in the microcirculation of the brain immmediately after CPB and for two days thereafter. However, by seven days the microvascular blockade had disappeared, and the vascular blockade had disappeared, and the vascular pattern of the brain had returned to normal. Neuropathological findings were sparse and restricted to the cerebellum. This study suggests that the transient neurological syndromes that sometimes follow cardiopulmonary bypass for heart surgery may be due to a transient microvascular blockade, perhaps by microbubbles and microparticles.  (+info)

A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction. (5/1874)

Milrinone is used during cardiac surgery to facilitate separation from cardiopulmonary bypass (CPB) and/or to treat myocardial dysfunction in the post-bypass period. We have demonstrated, in patients with preoperative depression of systolic function undergoing aorto-coronary artery bypass surgery, sustained improvement in cardiac function after a single loading dose of milrinone 50 micrograms kg-1, administered at the end of bypass, thus significantly decreasing the need for beta-agonist therapy.  (+info)

Effect of cardiopulmonary bypass and heparin on plasma levels of Lp(a) and Apo(a) fragments. (6/1874)

Fragments of apolipoprotein(a) [apo(a)], the distinctive glycoprotein of lipoprotein(a) [Lp(a)], are present in human plasma and urine and have been implicated in the development of atherosclerosis. The mechanism responsible for the generation of apo(a) fragments in vivo is poorly understood. In this study, we examined the plasma levels of Lp(a) and apo(a) fragments [or free apo(a)] and urinary apo(a) in 15 subjects who underwent cardiac surgery necessitating cardiopulmonary bypass. We also measured the plasma concentration and activity of polymorphonuclear elastase, an Lp(a)-cleaving enzyme in vitro, and plasma levels of C-reactive protein. Despite a marked activation of polymorphonuclear cells and a pronounced inflammatory response, as documented by an 8-fold and a 35-fold increase in plasma levels of polymorphonuclear elastase and C-reactive protein, respectively, the proportion of plasma free apo(a) to Lp(a) and urinary excretion of apo(a) remained unchanged over a 7-day period after surgery, and polymorphonuclear elastase activity remained undetectable in plasma. No fragmentation of apo(a) was observed ex vivo in plasma samples collected before and after surgery. These data indicate that in this model, apo(a) is not fragmented in plasma and are consistent with the hypothesis that apo(a) fragments result from a constitutively active tissue mechanism that is not modified by cardiac surgery with cardiopulmonary bypass.  (+info)

Intraoperative cardiac troponin T release and lactate metabolism during coronary artery surgery: comparison of beating heart with conventional coronary artery surgery with cardiopulmonary bypass. (7/1874)

OBJECTIVE: To compare cardiac troponin T release and lactate metabolism in coronary sinus and arterial blood during uncomplicated coronary grafting on the beating heart with conventional coronary grafting using cardiopulmonary bypass. DESIGN: A prospective observational study with simultaneous sampling of coronary sinus and arterial blood: before and 1, 4, 10, and 20 minutes after reperfusion for analysis of cardiac troponin T and lactate. Cardiac troponin T was also analysed in venous samples taken 3, 6, 24, 48, and 72 hours after surgery. SETTING: Cardiac surgical unit in a tertiary referral centre. PATIENTS: 18 patients undergoing coronary grafting on the beating heart (10 single vessel and eight two-vessel grafting) and eight undergoing two-vessel grafting with cardiopulmonary bypass. RESULTS: Cardiac troponin T was detected in coronary sinus blood in all patients by 20 minutes after beating heart coronary artery surgery before arterial concentrations were consistently increased. Peak arterial and coronary sinus cardiac troponin T values on the beating heart during single (0.03 (0 to 0. 05) and 0.09 (0.07 to 0.16 microg/l, respectively) and two-vessel grafting (0.1 (0.07 to 0.11) and 0.19 (0.14 to 0.25) microg/l) were lower than the values obtained during cardiopulmonary bypass (0.64 (0.52 to 0.72) and 1.4 (0.9 to 2.0) microg/l) (p < 0.05). The area under the curve of venous cardiac troponin T over 72 hours for two-vessel grafting on the beating heart was less than with cardiopulmonary bypass (13 (10 to 16) v 68 (26 to 102) microg.h/l) (p < 0.001). Lactate extraction began within one minute of snare release during beating heart coronary surgery while lactate was still being produced 20 minutes after cross clamp release following cardiopulmonary bypass. CONCLUSIONS: Lower intraoperative and serial venous cardiac troponin T concentrations suggest a lesser degree of myocyte injury during beating heart coronary artery surgery than during cardiopulmonary bypass. Oxidative metabolism also recovers more rapidly with beating heart coronary artery surgery than with conventional coronary grafting. Coronary sinus cardiac troponin T concentrations increased earlier and were greater than arterial concentrations during beating heart surgery, suggesting that this may be a more sensitive method of intraoperative assessment of myocardial injury.  (+info)

Urgent homograft aortic root replacement for aortic root abscess in infants and children. (8/1874)

OBJECTIVE: To assess the results of early homograft aortic root replacement in infants and children with an aortic root abscess. DESIGN: Descriptive study of all patients with an aortic root abscess during 1987-97, identified by retrospective review of the echocardiographic and surgical registries. SETTING: A tertiary referral centre. PATIENTS: Five patients (age 0.6 to 13 years; two female) were identified with an aortic root abscess. Four had no known pre-existing congenital heart abnormality. Three had a misleading presentation and were referred to our hospital with non-cardiac diagnoses (fulminant hepatic failure; adult respiratory distress syndrome; cerebrovascular accident). The other two presented with septicaemia and a murmur, respectively. Blood cultures identified Staphylococcus aureus (n = 3) and Streptococcus pneumoniae (n = 2). Aortic root abscess was diagnosed by transthoracic echocardiography. INTERVENTIONS: Homograft aortic root replacement with coronary reimplantation was performed urgently (median one day after diagnosis). RESULTS: Four patients survived. The youngest died following multiorgan failure, multiple aortic fistulae, three valve involvement, and extensive tissue destruction preventing mitral valve replacement (S pneumoniae). Two of the four survivors have required further surgery: mitral valve replacement (0.3 years later), and pulmonary autograft replacement of the homograft (8.3 years later). All survivors remain in sinus rhythm and New York Heart Association functional class I. CONCLUSIONS: Infective endocarditis should be considered in any child with severe septicaemia or embolic phenomena. Echocardiographic diagnosis of an aortic root abscess indicates uncontrolled infection and impending haemodynamic collapse. Homograft aortic root replacement can be performed successfully in critically ill children with active infection.  (+info)

TY - JOUR. T1 - Thrombography reveals thrombin generation potential continues to deteriorate following cardiopulmonary bypass surgery despite adequate hemostasis. AU - Wong, Raymond K.. AU - Sleep, Joseph R.. AU - Visner, Allison J.. AU - Raasch, David J.. AU - Lanza, Louis A.. AU - DeValeria, Patrick A.. AU - Torloni, Antonio S.. AU - Arabia, Francisco A.. PY - 2011/3/1. Y1 - 2011/3/1. N2 - The intrinsic and extrinsic activation pathways of the hemostatic system converge when prothrombin is converted to thrombin. The ability to generate an adequate thrombin burst is the most central aspect of the coagulation cascade. The thrombin-generating potential in patients following cardiopulmonary bypass (CPB) may be indicative of their hemostatic status. In this report, thrombography, a unique technique for directly measuring the potential of patients blood samples to generate adequate thrombin bursts, is used to characterize the coagulopathic profile in post-CPB patients. Post-CPB hemostasis is ...
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
Cardiopulmonary bypass (CPB) induces hemodilutional anemia, which frequently requires the transfusion of blood products. The objective of this study was to evaluate oxygen delivery and consumption and clinical outcome in low risk patients who were allocated to an hematocrit (Hct) of 20% versus 25% during normothermic CPB for elective coronary artery bypass graft (CABG) surgery. This study was a prospective, randomized and controlled trial. Patients were subjected to normothermic CPB (35 to 36°C) and were observed until discharge from the intensive care unit (ICU). Outcome measures were calculated whole body oxygen delivery, oxygen consumption and clinical outcome. A nonparametric multivariate analysis of variance for repeated measurements and small sample sizes was performed. In a total of 54 patients (25% Hct, n = 28; 20% Hct, n = 26), calculated oxygen delivery (p = 0.11), oxygen consumption (p = 0.06) and blood lactate (p = 0.60) were not significantly different between groups. Clinical outcomes
TY - JOUR. T1 - Pulmonary perfusion with L-arginine ameliorates post-cardiopulmonary bypass lung injury in a rabbit model. AU - Chao, Yin Kai. AU - Wu, Yi Cheng. AU - Yang, Kun Ju. AU - Chiang, Ling Ling. AU - Liu, Hui Ping. AU - Lin, Pyng Jing. AU - Chu, Yen. PY - 2011/5/15. Y1 - 2011/5/15. N2 - Background: Post-cardiopulmonary bypass (CPB) lung injury is the combination of whole body inflammatory response and local ischemia-reperfusion (IR) injury. We investigated the benefit of pulmonary perfusion with L-arginine in protection against post-CPB lung injury. Methods: New Zealand white rabbits (n = 50, weight, 2.5-2.8 kg) were divided into five groups (n = 10 each): sham (sham sternotomy), CPB (CPB without pulmonary perfusion), perfusion (CPB with pulmonary perfusion), L-arginine (CPB with perfusion + L-arginine), and L-NAME (CPB with perfusion + L-NAME). The duration of CPB was 60 min followed by 2 h of reperfusion. Pulmonary perfusion was performed every 20 min through the pulmonary artery ...
TY - JOUR. T1 - Phenylephrine increases cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwariz, Arthur E.. AU - Minanov, Oktavijan. AU - Stone, J. Gilbert. AU - Adams, David C.. AU - Sandhu, Aqeel A.. AU - Pearson, Mark E.. AU - Kwiatkowski, Pawel. AU - Young, William L.. AU - Michler, Robert E.. PY - 1996/8/23. Y1 - 1996/8/23. N2 - Background: Although low-flow cardiopulmonary bypass (CPB) has become a preferred technique for the surgical repair of complex cardiac lesions in children, the relative hypotension and decrease in cerebral blood flow (CBF) associated with low flow may contribute to the occurrence of postoperative neurologic injury. Therefore, it was determined whether phenylephrine administered to increase arterial blood pressure during low-flow CPB increases CBF. Methods: Cardiopulmonary bypass was initiated in seven baboons during fentanyl, midazolam, and isoflurane anesthesia. Animals were cooled at a pump flow rate of 2.5 1 · min -1 · m ...
TY - JOUR. T1 - Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal piglet model. AU - Ündar, Akif. AU - Masai, Takafumi. AU - Yang, Shuang Qiang. AU - Eichstaedt, Harald C.. AU - McGarry, Mary Claire. AU - Vaughn, William K.. AU - Fraser, Charles D.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. Ten piglets underwent PP (n = 5) or NPP (n = 5). After initiation of CPB, all animals underwent 15 minutes of core cooling (25°C), 60 minutes of hypothermic CPB ...
TY - JOUR. T1 - Heparin-protamine balance after neonatal cardiopulmonary bypass surgery. AU - Peterson, J. A.. AU - Maroney, S. A.. AU - Zwifelhofer, W.. AU - Wood, J. P.. AU - Yan, K.. AU - Bercovitz, Rachel Sara. AU - Woods, R. K.. AU - Mast, A. E.. PY - 2018/10. Y1 - 2018/10. N2 - Essentials Heparin-protamine balance (HPB) modulates bleeding after neonatal cardiopulmonary bypass (CPB). HPB was examined in 44 neonates undergoing CPB. Post-operative bleeding occurred in 36% and heparin rebound in 73%. Thrombin-initiated fibrin clot kinetic assay and partial thromboplastin time best assessed HPB. Summary: Background Neonates undergoing cardiopulmonary bypass (CPB) are at risk of excessive bleeding. Blood is anticoagulated with heparin during CPB. Heparin activity is reversed with protamine at the end of CPB. Paradoxically, protamine also inhibits blood coagulation when it is dosed in excess of heparin. Objectives To evaluate heparin-protamine balance in neonates undergoing CPB by using research ...
TY - JOUR. T1 - Cerebral blood flow during low-flow hypothermic cardiopulmonary bypass in baboons. AU - Schwartz, A. E.. AU - Kaplon, R. J.. AU - Young, W. L.. AU - Sistino, J. J.. AU - Kwialkowski, P.. AU - Michler, R. E.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Background: Neurologic injury after cardiopulmonary bypass (CPB) is a frequent and devastating complication of cardiothoracic surgery. Disordered cerebral hemodynamics during CPB has been implicated as an important factor in the etiology of these injuries. Evidence of disordered cerebral hemodynamics includes reports of a progressive time-dependent decrease in cerebral blood flow (CBF) during stable full-flow CPB. Low-flow hypothermic CPB has become a preferred technique for the management of pediatric patients undergoing surgical repair of complex cardiac lesions. Because CBF is already substantially reduced with the onset of low-flow CPB, we determined if a similar progressive decline in CBF occurs during the low-flow state. Methods: After ...
TY - JOUR. T1 - Effects of coronary revascularization with or without cardiopulmonary bypass on plasma levels of asymmetric dimethylarginine. AU - Cziráki, Attila. AU - Ajtay, Zénó. AU - Németh, Ádám. AU - Lenkey, Zsófia. AU - Sulyok, Endre. AU - Szabados, Sándor. AU - Alotti, Nasri. AU - Martens-Lobenhoffer, Jens. AU - Szabó, Csaba. AU - Bode-Böger, Stefanie M.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Objectives: We measured and compared serum asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and L-arginine levels in patients undergoing coronary artery revascularization. Methods: Two groups of patients with coronary artery disease were subjected to coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB; n=20) or with off-pump CABG surgery (OPCABG; n=21). Blood samples for measurements of ADMA, SDMA, and L-arginine were withdrawn and determined by liquid chromatography-tandem mass spectrometry from the coronary sinus (CS) and from the peripheral ...
TY - JOUR. T1 - Nonpulsatile cardiopulmonary bypass disrupts the flow-metabolism couple in the brain. AU - Andersen, K.. AU - Waaben, J.. AU - Husum, B.. AU - Voldby, B.. AU - Bødker, A.. AU - Hansen, A. J.. AU - Gjedde, A.. PY - 1985. Y1 - 1985. N2 - The effect of cardiopulmonary bypass on the relationship between brain glucose consumption and regional blood flow is unknown. We measured this relationship in pigs subjected to 3 hours of pulsatile or nonpulsatile cardiopulmonary bypass at normothermia and compared the results to the relationship established in a control group of pigs. A total of 10 regions were sampled in both hemispheres of the porcine brain. In control pigs, cerebral blood flow averaged 46 ml/100 gm and the glucose consumption, 21 μmol/100 gm/min. The ratio between blood flow and glucose consumption was close to 2 ml/μmol in all regions. In pulsatile cardiopulmonary bypass both the whole-brain average and the regional values declined, so that the ratio remained the same, ...
Data & statistics on Carbon dioxide transfer rate in relation to cardiopulmonary bypass times: Carbon dioxide transfer rate in relation to cardiopulmonary bypass times, Shown in piglets undergoing deep hypothermic circulatory arrest (DHCA) with or without selective cerebral perfusion (SCP). Cerebral tissue oxygenation (Pbto2) is shown as relative units (RU), normalized to before cardiopulmonary bypass baseline (BL; mm Hg). Measurements are shown at the following times: BL, before cardiopulmonary bypass baseline; Cool, cooling; CA30, 30 minutes of DHCA; eCA, end DHCA; ..., Intraoperative SctO2 course of a patient undergoing aortic arch surgery with hypothermic circulatory arrest. Note dependency of SctO2 to CO2. Insufflation of CO2 during endoscopic vein harvesting leading to increase in SctO2 as well as decline in SctO2 once mechanical ventilation was started. CPB = cardiopulmonary bypass; DHCA = deep hypothermic circulatory arrest....
The major source of morbidity following cardiopulmonary bypass (CPB) is the systemic inflammatory response (SIRS response) which leads to multiple derangements in different organ systems. To combat this, miniaturized cardiopulmonary bypass circuits (MCPBC) have been created to lessen the inflammatory response to CPB. Here we examine early outcomes following coronary artery bypass grafting (CABG) using a MCPBC system compared to conventional bypass techniques at a single institution. Methods: 60 consecutive patients undergoing elective CABG were prospectively enrolled. Nine patients underwent coronary artery bypass grafting (CABG) with conventional CPB (cCABG), 33 underwent off-pump CABG (OPCAB), and the remaining 18 patients underwent CABG with a MCPBC system. Demographics and outcomes were compared between groups and statistical analyses applied. Results: No significant difference was observed in mortality between groups, with only one death reported in total. Morbidity was also low, totaling only 6.7%
Objective: We assessed the causes of imbalance of oxygen transport by continuously measuring oxygen consumption (VO2) during hypothermic cardiopulmonary bypass (CPB) in pigs. Methods: Six pigs (17.2±1.6 kg) underwent hypothermic (32°C) CPB for 180 min with 120 min of aortic crossclamping (ACC). An AMIS 2000 mass spectrometer was adapted for the on-line measurement of VO2. Arterial lactate was measured at the beginning of CPB, the end of hypothermia, before and 10 min after ACC release, 20 min later, and at the end of CPB. Results: Arterial lactate increased from 1.8±0.7 to 5.1±1.8 mmol/L during CPB. Hypothermia reduced VO2 by 0.63±0.29 ml/min/kg per °C, but lactate increased to 4.2±1.5 mmol/L ( ...
View more ,A telephone survey of cardiac anaesthetists and perfusionists at the 29 public hospitals providing adult cardiac surgical services in Australia and New Zealand was carried out between December 2019 and January 2020. The aim was to investigate current practice with regard to selected contentious elements of anaesthetic and perfusion management during cardiopulmonary bypass; primarily relating to bypass circuit priming, blood conservation methods and point-of-care coagulation testing. There was a 100% response rate. The average number of adult public cardiopulmonary bypass cases per hospital was 508 (160-1400). For cardiopulmonary bypass cases, ten hospitals (34%) routinely used a cell saver and the remainder used a cell saver selectively. Residual blood remaining in the cardiopulmonary bypass circuit was processed using a cell saver routinely in four hospitals (14%) and selectively in 23 (79%). Acute normovolaemic haemodilution was rarely used. Retrograde autologous priming was used ...
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Measurements and results: Subjects were observed for 24 hours; during surgery, 6 and 24 hours after aortic clamp removed. During July 2012 - December 2013, there were 52 patients who became subjects. There were proportion differences between cardiac lactate and cardiac output change after cardiac surgery. Increase of cardiac lactate has a correlation with increasing levels of sTNFR-1 and IL-6 and decreasing index of Tc, ScvO2 and cardiac output. There were correlations among low index of ScvO2, high index of cardiac lactate and decrease of cardiac output. High sTNFR-1 and IL-6 were correlated to low cardiac output. Cardiac lactate, ScvO2 and MAP can be used as predictors of cardiac output change in patients with cardio-pulmonary bypass. sTNFR-1 and IL-6 levels were correlated with cardiac output changes after cardiac surgery ...
Over a three year period we have used haemodialysis and haemofiltration in parallel with cardiopulmonary bypass in 26 patients. Impaired renal function and excessive fluid retention have been the main indications. Patients on haemodialysis programmes for end stage renal failure did not require further dialysis until at least the third postoperative day, when they could tolerate the haemodynamic disturbance of dialysis. In the other patients these techniques proved valuable in reversing the effects of haemodilution and in controlling the concentration of serum potassium. Our experience has confirmed that haemodialysis and haemofiltration in parallel with cardiopulmonary bypass are useful adjuncts in the perioperative management of patients with impaired renal function undergoing open heart surgery. The techniques are also effective in correcting the fluid retention and biochemical imbalance in patients with congestive cardiac failure, including those with heart transplants.. ...
Established as the standard reference on cardiopulmonary bypass, Dr. Gravlees text is now in its Third Edition. This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications. This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on circulatory support for minimally invasive cardiac surgery. Other highlights include state-of-the-art information on low-volume circuits and other new equipment and discussions of outcomes data for on-pump and off-pump surgeries ...
Acute kidney injury, a prevalent complication of cardiac surgery performed on cardiopulmonary bypass (CPB), is thought to be driven partly by hypoxic damage in the renal medulla. To determine the causes of medullary hypoxia during CPB, we modeled its impact on renal hemodynamics and function, and thus oxygen delivery and consumption in the renal medulla. The model incorporates autoregulation of renal blood flow and glomerular filtration rate and the utilization of oxygen for tubular transport. The model predicts that renal medullary oxygen delivery and consumption are reduced by a similar magnitude during the hypothermic (down to 28°C) phase of CPB. Thus, the fractional extraction of oxygen in the medulla, an index of hypoxia, is increased only by 58% from baseline. However, during the rewarming phase (up to 37°C), oxygen consumption by the medullary thick ascending limb increases 2.3-fold but medullary oxygen delivery increases only by 33%. Consequently, the fractional extraction of oxygen in ...
BACKGROUND: After cardiac surgery with cardiopulmonary bypass (CPB), acquired coagulopathy often leads to post-CPB bleeding. Though multifactorial in origin, this coagulopathy is often aggravated by deficient fibrinogen levels. OBJECTIVE: To assess whether laboratory and thrombelastometric testing on CPB can predict plasma fibrinogen immediately after CPB weaning. PATIENTS / METHODS: This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-CPB bleeding compares fibrinogen level (Clauss method) and function (fibrin-specific thrombelastometry) in order to study the predictability of their course early after termination of CPB. Linear regression analysis and receiver operating characteristics were used to determine correlations and predictive accuracy. RESULTS: Quantitative estimation of post-CPB Clauss fibrinogen from on-CPB fibrinogen was feasible with small bias (+0.19 g/l), but with poor precision and a percentage of error |30%. A clinically usefu
Summary. Background: Bleeding after cardiopulmonary bypass (CPB) is a major cause of morbidity and mortality and consumes large amounts of blood. Identifying patients at increased risk of bleeding secondary to hemostatic impairment may improve clinical outcomes by allowing early intervention. Methods: This present study recruited 77 patients undergoing CPB and measured coagulation screens, coagulation factors, TEG®, Rotem® and thrombin generation (TG) before surgery and 30 min after heparin reversal. The tests were analyzed to investigate whether they identified patients at increased risk of excess bleeding (defined as , 1000 mL) in the first 24 h postoperatively. Results: Patients who bled , 1000 mL had a lower: platelet count (P , 0.02), factors (F)IX, X and XI (P , 0.005), endogenous thrombin potential (ETP) and an initial rate of TG (P , 0.02) and higher activated partial thromboplastin time (aPTT) (P , 0.001) than patients who bled , 1000 mL. Receiver operating characteristic (ROC) ...
Cyanotic congenital heart disease comprises a diverse spectrum of anatomical pathologies. Common to all, however, is chronic hypoxia before these lesions are operated upon when cardiopulmonary bypass is initiated. A range of functional and structural adaptations take place in the chronically hypoxic heart, which, whilst protective in the hypoxic state, are deleterious when the availability of oxygen to the myocardium is suddenly improved. Conventional cardiopulmonary bypass delivers hyperoxic perfusion to the myocardium and is associated with cardiac injury and systemic stress, whilst a normoxic perfusate protects against these insults.
Click the title to purchase the article.. Abstract:. Femoro-femoral cardiopulmonary bypass (CPB) followed by deep hypothermic circulatory arrest is one of the modalities used for ascending aortic pseudoaneurysmrepair to achieve cardiac unloading and to avoid severe hemorrhage due to the risk of rupture during the sternal entry. However, due to the limited size of the cannulas, it can be challenging to achieve total cardiopulmonary support. Therefore, despite the achievement of total cardiopulmonary support, the heart may still be able to eject antegrade blood flow that meets the retrograde blood flow from the arterial side of the CPB. The point where the blood flow meets in the aorta is called the watershed area. If the antegrade blood flow is large due to a left ventricular ejection, the watershed area will be located in the descending aorta. Therefore, if ventilation is stopped, deoxygenated blood will be ejected to the cerebral circulation. Cerebral near-infrared spectroscopy (NIRS) may be ...
OBJECTIVE: The purpose of this study was to determine whether cognitive impairment is related to cardiopulmonary bypass. METHODS: Twenty-five patients undergoing coronary artery bypass grafting without cardiopulmonary bypass were matched with 50 patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. All patients received the same anesthetic regimen, and one surgeon performed all the operations. A battery of 10 standard tests of neuropsychologic function were performed before, at discharge, and 3 months after the operation. A comprehensive multidimensional measure of subjective health status was used as the primary clinical measure of functional outcome. RESULTS: The groups were similar with respect to age, sex, and ventricular function and differed only in the need for a circumflex artery graft. Both groups showed significant improvement in the comprehensive multidimensional measure of subjective health status at 3 months. At discharge most neuropsychologic tests had
TY - JOUR. T1 - Enhancement of brain pO2 during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution. AU - Runge, T. M.. AU - McGinity, J. W.. AU - Frisbee, S. E.. AU - Briceno, J. C.. AU - Ottmers, S. E.. AU - Calhoon, John H. AU - Hantler, C. B.. AU - Korvick, D. L.. AU - Ybarra, J. R.. PY - 1997/5. Y1 - 1997/5. N2 - During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory. The incidence of the syndrome appears to be no less that 30% in patients over 65 years of age undergoing cardiac surgery. There are several factors contributing to hypoxia produced by cardiopulmonary bypass. One of these factors is crystalloid pump prime and replacement solutions devoid of (1) oxygen carrying capacity and (2) devoid of protein and its colloid osmotic pressure. This shortcoming of cardiopulmonary crystalloid solutions is partially responsible for two of the three major pathologic effects of ...
To the best of our knowledge, this is the first prospective study evaluating cognitive function before and after cardiopulmonary bypass in children. We found that the relatively short period of mildly hypothermic cardiopulmonary bypass was not associated with any change in cognitive function. The results of this study differ from the findings of a previous study that showed a 9.5-point deficit in full IQ and a deficit in nonverbal information processing in subjects who underwent surgical repair of an ASD compared with subjects who underwent ASD repair via a catheter-delivered device.15 Furthermore, although the previous study showed group differences in visual-spatial skills,15 we found no evidence to indicate that visual-spatial skills deteriorate after surgical repair of an ASD. Specifically, comparisons of nonverbal and spatial information processing in our sample suggest consistency of performance over time. In fact, a small increase was seen in the postoperative test scores. Although these ...
BACKGROUNDDiabetes mellitus is an independent risk factor for early postoperative mortality and complications after coronary artery bypass grafting (CABG). We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes.METHODS AND RESULTSTwenty atrial myocardium samples were harvested from 5 type II insulin-dependent diabetic and 5 matched nondiabetic patients undergoing CABG, before and after CPB/C. Oligonucleotide microarray analyses of 12625 genes were performed on the 10 sample pairs using matched pre-CPB tissues as controls. Array results were validated with Northern blotting and immunoblotting. Compared with pre-CPB/C, post-CPB/C myocardial tissues revealed 851 upregulated and 480 downregulated genes with a threshold P, or =0.025 (signal-to-noise ratio, 4.04) in the diabetic group, compared with 480 upregulated and 626 downregulated genes (signal-to-noise ratio, 3.04) in the nondiabetic group ...
During conventional cardiopulmonary bypass (CPB) there is no active perfusion of the pulmonary circulation and the mechanical ventilation is ceased leaving the lungs exposed to warm ischemia. Pulmonary dysfunction is seen in varying degrees after major surgery, but more severe in cardiac surgery patients probably due to the effects of CPB. The evidence for effect and safety are limited, but active pulmonary artery perfusion during CPB could be beneficial for the patients postoperative oxygenation. Our aim was in a randomised clinical trial to assess primarily the effect of pulmonary artery perfusion during CPB on postoperative oxygenation in patients diagnosed with chronic obstructive pulmonary disease (COPD), secondarily to assess other possible benefits and harms. Furthermore, we wanted in a systematic review with meta-analyses of all randomised clinical trials to investigate the pooled effects of pulmonary artery perfusion during CPB. We planned and conducted a randomised, partly blinded, ...
Michael Manning, MD, PhD, Research Fellow and Medical Instructor in the Division of Cardiothoracic Anesthesiology was awarded a two-year $50,000 Society of Cardiovascular Anesthesiologists (SCA) Starter Grant entitled Atrial Fibrillation Following Cardiopulmonary Bypass: The Role of Angiotensin II.. Post-operative atrial fibrillation (POAF) occurs in 30-60% of cardiac surgical patients, and is associated with increased morbidity and mortality. Preventative treatment options for this significant problem are lacking, with most therapy instituted after onset of POAF when associated risks, including stroke, are highest. Evidence suggests a key role for inflammation in the genesis and perpetuation of POAF through structural changes in the atrial wall; this may serve as a point for intervention and prevention, thereby decreasing overall morbidity and mortality.. Patients who undergo cardiac surgery with cardiopulmonary bypass (CPB) experience a significant inflammatory reaction, which has been ...
Epinephrine-induced lactic acidosis following cardiopulmonary bypass. Department of Intensive Care, Royal North Shore Hospital, St. Leonards, NSW, Australia. To determine if lactic acidosis occurring after cardiopulmonary bypass could be attributed to the metabolic or other effects of epinephrine administration. Posts
OBJECTIVES A meta-analysis was conducted to investigate the effects of ulinastatin treatment on adult patients undergoing cardiac surgery under cardiopulmonary bypass (CPB). METHODS Seven electronic databases were searched for reports of randomized, controlled trials conducted up to February 2014 in which patients undergoing cardiac surgery with CPB were administered ulinastatin in the perioperative period. RESULTS Fifty-two studies with 2025 patients were retained for analysis. The results showed that the ulinastatin can attenuate the plasma levels of pro-inflammatory cytokines and enhance the anti-inflammatory cytokine levels in patients undergoing cardiac surgery with CPB. Meanwhile, the ulinastatin had a significant beneficial effect on myocardial injury. The mean differences (MD) and 95% confidence intervals (95% CI) of biochemical markers were -63.54 (-79.36, -47.72) for lactate dehydrogenase, -224.99 (-304.83, -145.14) for creatine kinase, -8.75 (-14.23, -3.28) for creatine kinase-MB, and -0
Cardiac surgery with cardiopulmonary bypass (CPB) may cause inflammatory responses, which can deteriorate the outcomes. Inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6,-8 and -10, can act as both the effector and the predictor for post-operative inflammatory responses. Plasma mitochondrial DNA (mtDNA) was found as a pro-inflammatory agent recently, which was released when cells were insulted. In the present study, we included 38 patients undergoing coronary artery bypass graft (CABG) to analyze their perioperative plasma mtDNA and levels of inflammatory cytokines. Blood samples were collected before aortic cross-clamping (T1), at the end of CPB (T2), 6 h post-CPB (T3), 12 h post-CPB (T4), and 24 h post-CPB (T5). Rt-PCR and specific ELISA kits were used to quantify the plasma mtDNA and inflammatory cytokines, respectively. Bivariate correlations analysis was used to check the correlations between plasma mtDNA and inflammatory cytokines respectively. Results shown that
The clinical importance of exercise testing and training in the healthcare management of young patients with cystic fibrosis (CF) is growing. The aim of the present study was to determine the incidence of airflow limitation following cardiopulmonary exercise testing (CPET) and heavy-intensity intermittent exercise (HIIE) in young patients with CF. Nineteen young patients with CF and respective paired-matched controls performed CPET and HIIE on separate days. Forced expiratory volume in one second (FEV1) was measured pre- and post each exercise modality. A fall in FEV1 of 10 % or greater was used to define airflow limitation. The incidence of airflow limitation was significantly greater in the CF group than in the controls following CPET (32 vs. 5 %; p = 0.03); however, no significant difference in the incidence of airflow limitation was shown following HIIE between the CF group and controls (11 vs. 16 %; p = 0.64 ...
TY - JOUR. T1 - S100B increases in cyanotic versus noncyanotic infants undergoing heart surgery and cardiopulmonary bypass (CPB). AU - Varrica, Alessandro. AU - Satriano, Angela. AU - Gavilanes, Antonio D W. AU - Zimmermann, Luc J. AU - Vles, Hans J S. AU - Pluchinotta, Francesca. AU - Anastasia, Luigi. AU - Giamberti, Alessandro. AU - Baryshnikova, Ekaterina. AU - Gazzolo, Diego. PY - 2019/4. Y1 - 2019/4. N2 - AIMS: S100B has been proposed as a consolidated marker of brain damage in infants with congenital heart disease (CHD) undergoing cardiac surgery and cardiopulmonary bypass (CPB). The present study aimed to investigate whether S100B blood levels in the perioperative period differed in infants complicated or not by cyanotic CHD (CHDc) and correlated with oxygenation status (PaO2).METHODS: We conducted a case-control study of 48 CHD infants without pre-existing neurological disorders undergoing surgical repair and CPB. 24 infants were CHDc and 24 were CHD controls. Blood samples for S100B ...
The modern era of myocardial revascularization with cardiopulmonary bypass began in 1954 when Dr. John Gibbon reported the development of the cardiopulmonary bypass machine.6 An additional seminal advance occurred with the development of coronary angiography by Mason Sones at the Cleveland Clinic in 1957, which opened the door to the elective treatment of coronary atherosclerosis by means of direct revascularization.7 Initial reports by Rene Favaloro and Donald B. Effler on their techniques to treat clinical events associated with stenotic lesions of the coronary arteries culminated in the first large series of aorto-to-coronary artery venous grafts reported in 1969.8 Simultaneously Dudley Johnson of Milwaukee published a series of 301 patients in 1969.9 The success of these techniques was soon demonstrated in larger series initiating the modern era of coronary artery surgery. ...
This study is a multi-institutional randomized double-blind placebo controlled trial of the use of glucocorticoids to improve the clinical course of neonates following cardiac surgery. Cardiopulmonary bypass (CPB) is critical to cardiac surgery, but the pathophysiologic processes engendered by CPB play an important role in post-operative recovery. The use, doses and schedule of glucocortiocoid administration to ameliorate these CPB induced processes is highly variable and without clear data to provide direction. The Primary Aim of this study is to compare the effects of intraoperative methylprednisolone to placebo on a composite morbidity-mortality outcome following neonatal CPB. Secondary Endpoints include: inotropic requirements, incidence of low cardiac output syndrome, fluid balance, ICU stay parameters, levels of inflammatory molecules, neuro-developmental outcomes, and safety parameters. The study will focus on neonates because their post-CPB clinical course is typically more severe, and ...
Studio Mouth-to-mouth: An obstacle to cardio-pulmonary resuscitation for lay-rescuers pubblicato come Lettera allEditore su Resuscitation sul numero di Dicembre 2014.. Riferimento bibliografico:. E. Baldi, D. Bertaia, S.Savastano Mouth-to-mouth: An obstacle to cardio-pulmonary resuscitation for lay-rescuers Resuscitation. 2014 Dec;85(12):e195-6. ...
xml version=1.0?,,rfc1807,,datestamp,2018-06-04T14:57:38.6619335,/datestamp,,bib-version,v2,/bib-version,,id,39473,/id,,entry,2018-04-18,/entry,,title,Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes,/title,,swanseaauthors,,author,,sid,f5da81cd18adfdedb2ccb845bddc12f7,/sid,,ORCID,0000-0002-6986-6449,/ORCID,,firstname,Richard,/firstname,,surname,Bracken,/surname,,name,Richard Bracken,/name,,active,true,/active,,ethesisStudent,false,/ethesisStudent,,/author,,/swanseaauthors,,date,2018-04-18,/date,,deptcode,STSC,/deptcode,,abstract,IntroductionThis study investigated the degree and direction (kHR) of the heart rate to performance curve (HRPC) during cardio-pulmonary exercise (CPX) testing and explored the relationship with diabetes markers, anthropometry and exercise physiological markers in type 1 diabetes (T1DM).Material and methodsSixty-four people with T1DM (13 females; age: 34 ± 8 years; HbA1c: 7.8 ...
The cardio-pulmonary therapy staff provides services for children who have problems with the heart or lungs. Cardio-pulmonary therapy highlights:
The average salary for a Cardio-Pulmonary Perfusionist is $123,776. Visit PayScale to research cardio-pulmonary perfusionist salaries by city, experience, skill, employer and more.
Website. Interests: The effect of venodilation-based constant preload volume loading on hemodynamic variability in surgical patients. Crisis Management and Team Training for hospital-based resuscitation.Mechanism of radial arterial pressure changes following cardiopulmonary bypass. ...
Lacza, Zsombor and Csordás, Attila and Horváth, Eszter Mária and Pankotai, Eszter and Szabó, Csaba (2009) Mitokondriális eredetű nitrogén szabadgyökök és ATP-függő K-csatornák szerepe az organellum működésében = The involvement of mitochondrial-derived nitrogen radicals and mitoK-ATP channels in the regulation of organelle function. Project Report. OTKA. Rőth, Erzsébet and Alotti, Nasri and Lantos, János and Csordás, Attila and Papp, Lajos (1999) Oxidative stress following cardiopulmonary bypass. Journal of Molecular and Cellular Cardiology, 31. A56. ISSN 0022-2828 ...
TY - JOUR. T1 - Potential role of endothelin receptor antagonists in the setting of cardiopulmonary bypass. T2 - Relevance to myocardial performance. AU - Ergul, Adviye. AU - Joffs, Cassandra. AU - Walker, Allyson C.. AU - Spinale, Francis G.. N1 - Funding Information: Supported in part by National Institutes of Health grants HL-45024 and HL-56603 (FGS) and American Diabetes Association award (AE) Address for correspondence: Adviye Ergul, Division of Cardiothoracic Surgery, STRB Suite 625, PO Box 250778, 114 Doughty Street, Charleston, SC 29425.. PY - 2001. Y1 - 2001. N2 - The ET ssytem is activated in cardiac surgical setting as evidenced by elevated systemic and myocardial ET-1 levels after coronary bypass grafting surgery which requires hypothermic cardioplegic arrest and cardiopulmonary bypass. Increased ET-1 may influence a number of clinical parameters in this setting. First, ET-1 may directly modulate myocardial contractile performance in the early postoperative period resulting in LV ...
The most common neurological deficits in children after surgery for congenital heart disease are fine and gross motor deficits. Recent magnetic resonance imaging studies have demonstrated a significant number of newly developed white matter (WM) lesions in infants after surgery. The present study describes region-specific WM development in the juvenile porcine brain, which is similar in developmental stage to the human newborn. Acute and long-term cellular responses to cardiopulmonary bypass in oligodendrocyte lineages and neuron-axonal elements, which are the most prominent cell populations in WM, have been observed. A uniquely susceptible cellular target of cardiopulmonary bypass-induced WM injury in the oligodendrocyte lineage, as well as maturation-dependent vulnerability of developing WM, was found. Oligodendrocyte progenitor cells, which mediate WM recovery function, are highly resistant to cardiopulmonary bypass-induced injury. Interestingly, oligodendrocyte progenitor cell number ...
The significance of acanthrocytes and red cell fragmentation was evaluated in 31 patients undergoing cardiopulmonary bypass. Seven patients served as controls, and 24 patients with valvular prosthesis were observed for a period of at least 2 weeks. In the control group minimal red cell fragmentation (2-3/10 hpf) was seen, while acanthrocytes were present only during and immediately after cardiopulmonary bypass. In seven patients with valvular replacement the results were similar to the control group. Six other patients showed increased red cell fragmentation (15/10 hpf). In three of these, red cell fragmentation disappeared by the third postoperative week, in two by ...
OBJECTIVE To investigate whether generation and liberation of bradykinin and histamine contribute to generalized edema formation in pediatric cardiopulmonary bypass surgery. DESIGN Prospective observational study. SETTING Pediatric heart surgery of a university hospital. PATIENTS Forty-one neonates, infants, and children undergoing cardiopulmonary bypass to correct congenital cardiac anomalies. INTERVENTIONS Plasma concentrations of bradykinin and histamine were determined before, during, and after cardiopulmonary bypass. Fluid balance was evaluated by control of fluid intake and output. MEASUREMENTS AND MAIN RESULTS The susceptibility to generalized edema formation increased significantly (r = -.457; p |.005) with decreasing age. Approximately three times higher plasma concentrations of bradykinin (p |.001) were found at the onset of anesthesia and during the total observation period in patients with a fluid retention of |6% of body weight compared with patients with a lower retention rate.
Extracorporeal circulation (ECC) methods are being increasingly used for mechanical support of respiratory and cardio-circulatory failure. Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient’s life by providing an appropriate blood flow and oxygen supply to principal organs. On the other hand, systemic inflammatory responses in patients undergoing cardiovascular surgery supported by CPB contribute significantly to CPB-associated mortality and morbidity. Our previous research showed that CPB causes a systemic inflammatory response and organ damage in a small animal CPB model. We have been studying the effects of hyperoxia and blood plasma substitute on CPB. In this review, we present a study focusing on the systemic inflammatory response during CPB, along with our findings.
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Coronary artery bypass grafting with extracorporal circulation is established as the golden standard. The conventional cardiopulmonary bypass (CPB) system is associated with inflammatory reaction, hemolysis, hemodilution an disturbances of the blood coagulation system. Also its well known that neurological disturbances caused by embolic material and air bubbles are potential risks of CPB. The new minimized perfusion circuit ROCsafeTM is a closed, reservoir-less, reduced prime, surface coated circuit, with optimized safety features in effectively eliminate both macro and micro air bubbles and should optimize the clinical outcome after CABG using cardiopulmonary bypass. ...
No cardiopulmonary bypass; instead, these procedures are performed on the normally beating heart. Few or no actual incisions ... These were performed epicardially, on the beating heart, without cardiopulmonary bypass or median sternotomy. Their method came ... without cardiopulmonary bypass. Until recently this was not thought possible; as recently as 2004, Dr. Cox defined the mini- ... and cardiopulmonary bypass (heart-lung machine; extracorporeal circulation). A series of improvements were made, culminating in ...
In the early 1990s, surgeons began to perform off-pump coronary artery bypass, done without cardiopulmonary bypass. In these ... Cardiopulmonary bypass was developed after surgeons realized the limitations of hypothermia in cardiac surgery: Complex ... Therefore, during such surgery, the heart is temporarily stopped, and the patient is placed on cardiopulmonary bypass, meaning ... Many thousands of these "blind" operations were performed until the introduction of cardiopulmonary bypass made direct surgery ...
ISBN 978-0-748-13143-3. Stoney, William S. (2009). "Evolution of Cardiopulmonary Bypass" (PDF). Circulation. American Heart ... Following the experimental trial in dogs, which by 1955 had demonstrated a 90% survival following heart-lung bypass, Kirklin's ... "Apparatus of the Gibbon type for mechanical bypass of the heart and lungs; preliminary report". Proc Staff Meet Mayo Clin. 30 ( ... prolific author and medical educator who is best remembered for refining John Gibbon's heart-lung bypass machine via a pump- ...
"The Development of Cardiopulmonary Bypass". Archived February 3, 2007, at the Wayback Machine ctsnet.org. Retrieved: January 19 ...
Cardiopulmonary bypass may be necessary. The internal mammary artery or saphenous vein can be used as grafts. The grafts are ... Cardiopulmonary bypass (CPB) / heart-lung machine: External pump to take over the function of both the heart and lungs. ... Coronary artery bypass surgery (CABG): Grafting an artery or vein from elsewhere to bypass a stenotic coronary artery. ... asystole is desired and induced during cardiopulmonary bypass through a cardioplegia solution containing very high amounts of ...
"Surgical myocardial revascularization without cardiopulmonary bypass". Annals of Thoracic Surgery. Archived from the original ...
Cardiopulmonary bypass (CPB) is not required. The kit is CE Marked and available in Europe. Several cases have been done in ... Should a thrombus form on the bioprosthetic valve in the bypass conduit, it will likely migrate to the lower half of the body ... 60% to 70% of the heart's output flows through the bypass to the aorta. The load on the heart is markedly reduced, and symptoms ... Thourani VH, Keeling WB, Guyton RA, Dara A, Hurst SD, Lattouf OM, Outcomes of Off-Pump Aortic Valve Bypass Surgery for the ...
... to develop a less traumatic cardiopulmonary bypass technique. They also designed a miniaturized Cardiopulmonary Support circuit ... "Extracorporeal blood circuit for cardiopulmonary bypass US20110040229 A1". Google. Retrieved 5 December 2014. CS1 maint: ... "EXTRACORPOREAL BLOOD CIRCUIT FOR CARDIOPULMONARY BYPASS". Justia. Retrieved 12 December 2014. CS1 maint: discouraged parameter ... "Extracardiac Fontan operation without cardiopulmonary bypass". The Annals of Thoracic Surgery. 63 (4): 1175-7. doi:10.1016/ ...
"Historical development of cardiopulmonary bypass in Minnesota". In Glenn P. Gravlee (ed.). Cardiopulmonary Bypass: Principles ... A bubble oxygenator is an early implementation of the oxygenator used for cardiopulmonary bypass. It has since been supplanted ...
"Surgical myocardial revascularization without cardiopulmonary bypass". 69 (4). April 2000: 1216-1221. Cite journal requires , ... "Heart bypass surgery done on 20-month-old". Hindustan Times. 29 May 2009. "20-month-old undergoes bypass surgery". Deccan ... 3 Month Old Gets New Life After Heart Surgery - 12 May 2007 Heart Bypass Surgery Done on 20 Month Old - 29 May 2009 20 Month ... Thoracic and Thoraco-abdominal aortic aneurysms, mitral valve surgery and the beating heart Coronary Artery Bypass surgery. "Dr ...
"Intra-abdominal Complications of Cardiopulmonary Bypass Operations". Surgery Gynecology and Obstetrics. 165 (3): 251-254. PMID ... "Intra-abdominal Complications of Cardiopulmonary Bypass Operations". Surgery, Gynecology & Obstetrics. 165 (3): 251-254. PMID ... Taylor JD, Leitman IM, Hon P, Horowitz M, Panagopoulos G (2006). "Outcome and complications of gastric bypass surgery in super- ... "Is routine cholecystectomy necessary at the time of roux-en-y gastric bypass for morbid obesity?". Obesity Surgery. 16 (6): 759 ...
The cardiopulmonary bypass is then initiated by inserting a cannula into the ascending aorta as distally from the aortic root ... General anaesthesia and cardiopulmonary bypass are used. The aorta and pulmonary artery are detached from their native roots ... using the same method as would be used prior to bypass; however, there is a third opportunity for this still later in the ...
Current results with cardiopulmonary bypass". The Journal of Thoracic and Cardiovascular Surgery. 143 (1): 144-151. doi:10.1016 ...
... surgical excision with use of temporary cardiopulmonary bypass". J Am Med Assoc. 167 (5): 557-60. doi:10.1001/jama. ... These procedures can be performed together with coronary artery bypass surgery or mitral valve repair. If heart failure ensues ... coronary artery bypass surgery and left ventricle remodeling surgery in heart failure patients. Results are expected to be ...
The advent of cardiopulmonary bypass in the United States during the 1950s allowed the heart to be stopped for surgery without ... Cardiopulmonary bypass machines allow blood circulation and cooling to continue below the temperature at which the heart stops ... In 1959, using cardiopulmonary bypass (CPB), Barnes Woodhall and colleagues at Duke Medical Center performed the first brain ... Cardiopulmonary bypass machines were essential to the development of deep hypothermic circulatory arrest (DHCA) in humans. By ...
The patient is put on a cardiopulmonary bypass machine, also known as the heart-lung machine. This machine breathes for the ... Later, with the innovation of cardiopulmonary bypass, the ball valve prosthesis was placed orthotopically (i.e. in same place ... The patient is taken off the cardiopulmonary bypass machine. Transesophageal echocardiogram (an ultrasound of the heart done ... Once on cardiopulmonary bypass, the patient's heart is stopped (cardioplegia). This can be done with a Y-type cardioplegic ...
Passaroni Andréia, Silva Marcos, Yoshida Winston (2014). "Cardiopulmonary bypass: development of John Gibbon's heart-lung ...
Michael DeBakey for blood transfusions while he was a medical student in 1932 and later used by him for cardiopulmonary bypass ... Passaroni, A. C; Silva, M. A; Yoshida, W. B (2015). "Cardiopulmonary bypass: Development of John Gibbon's heart-lung machine". ... using soft flat tubing was developed in 1992 for cardiopulmonary bypass systems. The first technically and commercially viable ... They are also used in heart-lung machines to circulate blood during a bypass surgery, and in hemodialysis systems, since the ...
May 1982). "Ischemic optic neuropathy: a complication of cardiopulmonary bypass surgery". Neurology. 32 (5): 560-2. doi:10.1212 ... Spine and cardiac bypass surgeries have the highest estimated incidences of PION, 0.028% and 0.018% respectively, and this is ...
At 21:40, she was connected to a cardiopulmonary bypass machine that warmed up her blood outside of her body before it was ... Deeper hypothermia is used, and survived, in cardiopulmonary bypass. ([1]) See also: Therapeutic hypothermia. Gilbert, Mads; ... Falkenberg and Næsheim, both doctors, began giving her cardiopulmonary resuscitation (CPR). The rescue helicopter soon arrived ...
"Percutaneous cannulation of the femoral vessels for cardiopulmonary bypass". Herz. 33 (5): 374-6. doi:10.1007/s00059-008-3043-2 ...
"Recent experiences with hexadimethrine for neutralizing heparin after cardiopulmonary bypass". Anaesthesia and Intensive Care. ...
... management during cardiopulmonary bypass". Anesthesia and Analgesia. 116 (6): 1210-1222. doi:10.1213/ANE.0b013e31827e4e62. ISSN ... trauma but also may be seen on a lesser scale as a result of interventions such as major surgery or cardiopulmonary bypass. The ...
An improved method of dealing with complications after cardiopulmonary bypass". The Journal of Thoracic and Cardiovascular ...
Except sepsis, other causes comprise severe acute pancreatitis, post cardiopulmonary bypass vasoplegia and other triggers for a ... Hirai, S (2003). "Systemic inflammatory response syndrome after cardiac surgery under cardiopulmonary bypass". Annals of ...
"Relative deficiency of arginine vasopressin in children after cardiopulmonary bypass". Critical Care Medicine. 38 (10): 2052-8 ... epinephrine alone in cardiopulmonary resuscitation". The New England Journal of Medicine. 359 (1): 21-30. doi:10.1056/ ... "A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation". The New England Journal of ... "Release of endogenous vasopressors during and after cardiopulmonary resuscitation". Heart. 75 (2): 145-50. doi:10.1136/hrt.75.2 ...
Misplaced Filter: Causes pericardiac tamponade requiring surgery under cardiopulmonary bypass. Filter Migration to Right Atrium ...
Yu, J; Xiao, YB; Wang, XY (2007). "Effects of preoperatively selected gut decontamination on cardiopulmonary bypass-induced ...
1984). "Successful cardiopulmonary bypass in diabetics with anaphylactoid reactions to protamine". Br Heart J. 52 (1): 112-114 ... especially heart surgery where anti-coagulation is necessary to prevent clot formation within the cardiopulmonary bypass pump ... 2005). "Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery". ...
Cardiopulmonary bypass--triumph of perseverance and character". Clinical Cardiology. 17 (8): 456-7. doi:10.1002/clc.4960170811 ... on an 18-year-old patient using total cardiopulmonary bypass. The patient lived for over 30 more years. For this achievement, ...
... quick anti-Xa-activity-based whole blood coagulation assay for monitoring unfractionated heparin during cardiopulmonary bypass ...
"Coagulopathy After Cardiopulmonary Bypass in Jehovah's Witness Patients: Management of Two Cases Using Fractionated Components ...
Cardiopulmonary bypass. *Cardioplegia. *Extracorporeal membrane oxygenation. *Vascular access. *Revascularization. *First rib ... Angioscopy is also used as an adjunctive procedure during vascular bypass to visualize valves within venous conduits. The ...
a b Dörges V, Sauer C, Ocker H, Wenzel V, Schmucker P. Smaller tidal volumes during cardiopulmonary resuscitation: comparison ... A bypass clip is usually incorporated into this valve assembly in case medical needs call for inflation at a pressure beyond ... Hyperventilation-induced hypotension during cardiopulmonary resuscitation. Circulation 2004: 109:1960-1965. *^ Lee HM, Cho KH, ... Part 8: Adult Advanced Cardiac Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and ...
"Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass" at ClinicalTrials.gov ... Pexelizumab is a drug designed to reduce side effects of coronary artery bypass grafting[1] and angioplasty,[2][3] among other ... report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft ...
"Silastic drains vs conventional chest tubes after coronary artery bypass". Chest. 124 (1): 108-13. doi:10.1378/chest.124.1.108 ... Cardiopulmonary resuscitation (CPR). *Mouth-to-mouth resuscitation. *Basic life support (BLS). *Advanced cardiac life support ( ...
Cardiopulmonary bypass (or any other surgeries requiring temporary aortic occlusion)[28]. *Heart failure[29] ... Lander H, Zammert M, FitzGerald D (September 2016). "Anticoagulation management during cross-clamping and bypass". Best ...
en:Cardiopulmonary bypass (26). *en:Caregiver (15). *en:Cataract surgery (13). *en:Cause of death (16) ...
... is commonly used in the circuit prime of a heart lung machine during cardiopulmonary bypass. The presence of mannitol ... preserves renal function during the times of low blood flow and pressure, while the patient is on bypass. The solution prevents ...
Persistent free radicals connected to airborne fine particles are linked to cardiopulmonary disease.[16][17] ... should be permitted to bypass its government and deal directly with the European Commission regarding its air quality action ...
The Development of Cardiopulmonary Bypass. *^ Historical Heritage. *^ Frazier O.H. et al. "Cardiac Surgery in the Adult" Total ...
A variety of cannulae are used to establish cardiopulmonary bypass in cardiac surgery. A nasal cannula is a piece of plastic ...
Cardiopulmonary bypass. *Cardioplegia. *Isolated organ perfusion technique *Extracorporeal membrane oxygenation. *Vascular ...
In cardiac surgery, both with and without cardiopulmonary bypass (e.g., coronary artery bypass surgery), it is used to prevent ...
... quick anti-Xa-activity-based whole blood coagulation assay for monitoring unfractionated heparin during cardiopulmonary bypass ...
"The Development of Cardiopulmonary Bypass". Archived February 3, 2007, at the Wayback Machine ctsnet.org. Retrieved: January 19 ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... Cardiopulmonary bypass. *Cardioplegia. *Extracorporeal membrane oxygenation. *Vascular access. *Revascularization. *First rib ... An example is bypass surgery, where clogged blood vessels are bypassed with a graft from another part of the body. ...
For example, coronary artery bypass surgery (CABG), cardiopulmonary bypass and valve replacement are surgical procedures ... "Journal of Cardiopulmonary Rehabilitation and Prevention. 28 (6): 349-57. doi:10.1097/HCR.0b013e31818c3b96. PMC 2743684. PMID ... These two defects combined causes deoxygenated blood to bypass the lungs and going right back into the circulatory system. The ... This causes the deoxygenated blood to bypass the lungs and enter the circulatory system. Surgeries can fix this by redirecting ...
... recent editions of the American Heart Association's Guidelines for Cardiopulmonary Resuscitation have de-emphasized the role of ... developed a new technique for non-surgical orotracheal intubation to bypass laryngeal obstruction resulting from a diphtheria- ... "2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment ...
The heart and vessels are accessed via median sternotomy, and a cardiopulmonary bypass machine is used; as this machine needs ... in order for the red blood to bypass the lungs in utero, the fetal heart has two shunts that begin to close when the newborn ... circulation of a normal cardio-pulmonary system. Differences in the shape of the atrial septum and/or ventricular outflow ...
... coronary artery bypass surgery without the aforementioned cardiopulmonary bypass. In these operations, the heart is beating ... Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... The patient needs the function of the heart and lungs provided by an artificial method, hence the term cardiopulmonary bypass. ... In the long-run, pediatric cardiovascular surgery would rely on the cardiopulmonary bypass machine developed by Gibbon and ...
"Part 5: Adult Basic Life Support and Cardiopulmonary Resuscitation Quality - ECC Guidelines". eccguidelines.heart.org. ... Cricothyrotomy involves making an incision in a patient's neck and inserting a tube into the trachea in order to bypass the ... and other caregivers for children get training in choking first aid and cardiopulmonary resuscitation (CPR).[5] ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... This is the systemic circulation part of blood flow, the other loop of an interconnected normal cardio-pulmonary system. ...
Effects of Mild Hypothermic Cardiopulmonary Bypass on Blood Viscoelasticity in Coronary Artery Bypass Grafting Patients, ... A. Ündar, W. Vaughn, and J. Calhoon, The effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on blood ... Strong correlations between blood viscoelasticity and regional and global cerebral blood flow during cardiopulmonary bypass ...
Heart/Lung bypass. *Urinary catheterization. *Dialysis. *Cardiopulmonary resuscitation. *Defibrillation. *Artificial pacemaker ... In the case of cardiac injuries, cardiopulmonary resuscitation is initiated by bystanders or family members 25% of the time. ...
Bypass/Coronary artery bypass MIDCAB. Off-pump CAB. TECAB. Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall ... "Recovery of a hypothermic drowned child after resuscitation with cardiopulmonary bypass followed by prolonged extracorporeal ... Cardiopulmonary resuscitation (CPR) is an emergency procedure that combines chest compressions often with artificial ... July 2001). "Cardiopulmonary resuscitation performed by bystanders does not increase adverse effects as assessed by chest ...
Glenn P Gravlee;] -- This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections ... patient safety in cardiopulmonary bypass -- Unusual problems in cardiopulmonary bypass -- Termination of cardiopulmonary bypass ... bypass> # Cardiopulmonary Bypass a schema:Intangible ;. schema:name "Cardiopulmonary Bypass"@en ;. . ... patient safety in cardiopulmonary bypass --. Unusual problems in cardiopulmonary bypass --. Termination of cardiopulmonary ...
Cardiopulmonary bypass (CPB) protocols of the baboon (Papio cynocephalus anubis) are limited to obtaining experimental data ... Pediatric cardiopulmonary bypass adaptations for long-term survival of baboons undergoing pulmonary artery replacement.. * ... Cardiopulmonary bypass (CPB) protocols of the baboon (Papio cynocephalus anubis) are limited to obtaining experimental data ...
Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis ... Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis ... Paparella, D., Yau, T. M., & Young, E. (2002). Cardiopulmonary bypass induced inflammation: Pathophysiology and treatment. An ...
Find cardiopulmonary bypass stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in ... cardiopulmonary bypass images. 378 cardiopulmonary bypass stock photos, vectors, and illustrations are available royalty-free. ... cannula surgerystamach operationcardiac care technologycardiopulmonary machineheart lung machinecardiac surgery professionals ...
Suction devices used to clear the field of debris and provide adequate venting during cardiopulmonary bypass and accessory ... Cannulae used to facilitate adequate myocardial protection to the heart during cardiopulmonary bypass. ... infants and small children requiring cardiopulmonary bypass at flow rates up to 2.0 L/min ... PBS Portable Bypass System. "Go anywhere" flexibility of the complete unit in the OR, ER, cathlab, or emergency transport ...
This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on ... Established as the standard reference on cardiopulmonary bypass, Dr. Gravlees text is now in its Third Edition. This ... multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, ...
To compare cardiopulmonary bypass (CPB) with more conventional therapy in the treatment of severe amitriptyline poisoning. ... Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass.. Larkin GL1, ... Nine of ten swine treated with CPB were easily weaned off bypass without any pharmacologic intervention; however, one required ...
The portable and modular cardiopulmonary bypass apparatus has met the above mentioned needs. The apparatus consists of (i) a ... Cardiopulmonary bypass devices and methods. US20090018504 *. 20 Jun 2008. 15 Jan 2009. John Pile-Spellman. Systems and methods ... Peripheral cardiopulmonary bypass and coronary reperfusion system. US5069661 *. 18 May 1988. 3 Dec 1991. Brigham And Womens ... Cardiopulmonary bypass devices and methods. US9033298. 5 Apr 2012. 19 May 2015. Universitaetsklinikum Regensburg-Anstalt Des ...
Emergency cardiopulmonary bypass under ongoing CPR. Emergency cardiopulmonary bypass (ECMO: lifebridge (Sorin®) or cardiohelp( ... Emergency Cardiopulmonary Bypass After Cardiac Arrest With Ongoing Cardiopulmonary Resuscitation - a Pilot Randomized Trial. ... Emergency Cardiopulmonary Bypass for Cardiac Arrest (ECPB4OHCA). The safety and scientific validity of this study is the ... Emergency cardiopulmonary bypass (ECPB - artificial heart and lung outside the patients body) is a method which has shown good ...
Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ... Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ... Cardiopulmonary Bypass Induces Release of Soluble CD40 Ligand. Lisa Nannizzi-Alaimo, Mark H. Rubenstein, Veronica L. Alves, Gil ...
Cardiopulmonary Bypass: Emerging Trends and Continued Practices, A. H. Stammers. Boston: Little, Brown, & Co., 1996, ISBN 0020- ... Home , February 1997 - Volume 84 - Issue 2 , Cardiopulmonary Bypass: Emerging Trends and Continued Practi... ... This monograph is a compendium of 12 subject areas related to cardiopulmonary bypass and was edited by a perfusionist with ... Cardiopulmonary Bypass: Emerging Trends and Continued Practices. Hensley, Frederick A. Jr., MD ...
Over a three year period we have used haemodialysis and haemofiltration in parallel with cardiopulmonary bypass in 26 patients ... Our experience has confirmed that haemodialysis and haemofiltration in parallel with cardiopulmonary bypass are useful adjuncts ...
Cardiopulmonary Bypass: A Primer was published by the cardiac surgery team at the University of Washington, using the iBook ... Cardiopulmonary Bypass: A Primer. University of Washington Division of Cardiothoracic Surgery. Nahush A. Mokadam, MD, Editor ... Watching the blood flow into and out of the cardiopulmonary bypass machine makes it "real" for the inexperienced reader. ... Although we are well aware of the techniques for establishing, maintaining, and discontinuing cardiopulmonary bypass, we ...
Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children.. L M Pang, S A Stalcup, J S Lipset ... With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, ...
... Am J Respir Crit Care Med. 1995 Dec;152(6 Pt 1): ... Surgical correction of these cardiac defects frequently involves the use of cardiopulmonary bypass (CPB), during which the lung ...
What is cardiopulmonary bypass? Meaning of cardiopulmonary bypass medical term. What does cardiopulmonary bypass mean? ... Looking for online definition of cardiopulmonary bypass in the Medical Dictionary? cardiopulmonary bypass explanation free. ... intestinal bypass (jejunoileal bypass) see intestinal bypass.. left heart bypass diversion of the flow of blood from the ... Related to cardiopulmonary bypass: cardioplegia. bypass. [bi´pas″] an auxiliary flow; a shunt; a surgically created pathway ...
Historical development of cardiopulmonary bypass. In: Gravlee GP, Davis RF, Utley JR, eds. Cardiopulmonary Bypass: principles ... THE ADVENT OF CARDIOPULMONARY BYPASS. In the 19th century, the interest of physiologists in the circulation of blood turned to ... BLOOD PUMPS FOR CARDIOPULMONARY BYPASS. The search for pumps capable of displacing large volumes of blood deserves its own ... COMPLICATIONS OF CARDIOPULMONARY BYPASS. Due to its mechanical components and their interaction with blood, CPB can produce ...
Hypoxaemia during Cardio-Pulmonary Bypass. A. L. Muir, I. A. Davidson. Clinical Science Jul 01, 1970, 39 (1) 4P; DOI: 10.1042/ ...
One of my surgeons had to put a patient on Cardiopulmonary Bypass for another... ... Does any one know if there is a CPT for Cardiopulmonary Bypass Support only? ... Does any one know if there is a CPT for Cardiopulmonary Bypass Support only? One of my surgeons had to put a patient on ... Did you ever find out if there is a separate code for cardiopulmonary bypass only? ...
... series on cardiopulmonary bypass in which he discusses some of the fundamental concepts underlying cardiopulmonary bypass and ... Ismail A, Miskolczi S, Ohri S. Southampton Reviews in Cardiothoracic Surgery Chapter Two: Cardiopulmonary Bypass. March 2019. ... Southampton Reviews in Cardiothoracic Surgery Chapter Two: Cardiopulmonary Bypass Friday, March 1, 2019 ... Percutaneous and Open Cannulation for Peripheral Cardiopulmonary Bypass: Pearls and Pitfalls * Cardiopulmonary Bypass: An ...
... as a vasodilator during cardiopulmonary bypass was assessed in consecutive adult patients (n = 24) who demonstrated a high ... Cardiopulmonary Bypass*. Coronary Artery Bypass. Endothelins / blood. Epinephrine / blood. Female. Heart Defects, Congenital / ... Administration of exogenous adenosine triphosphate (ATP) as a vasodilator during cardiopulmonary bypass was assessed in ... This study confirmed the efficacy and safety of ATP infusion during cardiopulmonary bypass.. ...
Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 ... Acute renal injury is one of the most frequent complications after cardiopulmonary bypass (CPB). This study was designed to ...
141 consecutive patients underwent cardiac surgery requiring cardiopulmonary bypass at our hospital. We measured ACT 3 minutes ... "Evaluation of a New Formula for Calculating Heparin Dose for Cardiopulmonary Bypass Patients" written by Aya Nakasuji, Satoshi ... An Adjusted Calculation Model of Reduced Heparin Doses in Cardiopulmonary Bypass Surgery in a Chinese Population. Journal of ... An Adjusted Calculation Model of Reduced Heparin Doses in Cardiopulmonary Bypass Surgery in a Chinese Population ...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
Any patient undergoing elective (non-emergency) cardiopulmonary bypass for coronary artery bypass grafting, cardiac valve ... Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor. The safety and scientific ... Cardiopulmonary Bypass-Induced Lymphocytopenia and the Potential Effects of Protease Inhibitor in the Perioperative Period. ... In previous studies, 90% of patients who underwent elective cardiopulmonary bypass procedure manifested CD4 counts of less than ...
A comparison of retinal fluorescein angiograms taken before cardiopulmonary bypass with those taken just before the end of ...
Controversy continues as to whether hypotension during cardiopulmonary bypass (CPB) impairs intraoperative and postoperative ... Renal function and cardiopulmonary bypass: effect of perfusion pressure J Cardiothorac Vasc Anesth. 1992 Jun;6(3):299-303. doi ... Controversy continues as to whether hypotension during cardiopulmonary bypass (CPB) impairs intraoperative and postoperative ... Postoperative renal function was normal in all patients; no deleterious effect of a low arterial pressure during bypass could ...
Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy. Pappalardo, F.; Franco, A.; G., G. ... Cardiopulmonary bypass induces an ischaemia-reperfusion injury and systemic inflammatory response, which contributes to low ... Background: Accurate control of heparin anticoagulation is necessary during all stages of cardiopulmonary bypass (CPB). The ... Aprotinin protects the cerebral microcirculation during cardiopulmonary bypass. Ishibashi, N.; Iwata, Y.; Zurakowski, D.; Lidov ...
Acanthrocytes and Schistocytes After Cardiopulmonary Bypass. Richard V. Smalley, M.D.; Felix M. Cortes, M.D., F.A.C.P. ... Acanthrocytes and Schistocytes After Cardiopulmonary Bypass.. Ann Intern Med. 1969;70:1086. doi: 10.7326/0003-4819-70-5-1086_2 ... The significance of acanthrocytes and red cell fragmentation was evaluated in 31 patients undergoing cardiopulmonary bypass. ... while acanthrocytes were present only during and immediately after cardiopulmonary bypass. In seven patients with valvular ...
... provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for ... provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for ... Objectives In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) ... In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) ...
  • Conventional cardiopulmonary bypass delivers hyperoxic perfusion to the myocardium and is associated with cardiac injury and systemic stress, whilst a normoxic perfusate protects against these insults. (hindawi.com)
  • Perfusion pressure control by adenosine triphosphate given during cardiopulmonary bypass. (biomedsearch.com)
  • Cells passing through the roller pumps are damaged and release free radicals, patients receive cerebral emboli (gaseous or solid), and bypass pump flow and pressure are set arbitrarily without knowledge of the perfusion needed by the individual patient. (asahq.org)
  • Effects of pulmonary perfusion during cardiopulmonary bypass on lung functions after cardiac operation. (degasperis.it)
  • Pulmonary artery perfusion during cardiopulmonary bypass (CPB) is a known but rarely used technique in adult cardiac surgery. (degasperis.it)
  • Consensus statements from the Society of Cardiothoracic Surgery (SCTS) and the British Cardiovascular Intervention Society (BCIS) recommend that centres performing TAVI should have "immediate availability of perfusion services in case of the need for emergency bypass", and that this, together with other criteria, mean that TAVI should only be performed in units currently performing surgical aortic valve replacement. (bjcardio.co.uk)
  • Despite ∼10 000 children per year in the United States undergoing cardiac surgery before 12 months of age, 1 there is little known about the effects of cardiopulmonary bypass (CPB) on vaccine status. (aappublications.org)
  • Complement and the damaging effects of cardiopulmonary bypass. (bmj.com)
  • To investigate the in vivo effects of cardiopulmonary bypass (CPB) and perioperative hemodilution on human skeletal muscle oxygen delivery and metabolism and to determine the dilution state at which these effects arise. (springermedizin.de)
  • Kirklin JK, Westaby S, Blackstone EH, et al: Complement and the damaging effects of cardiopulmonary bypass. (biomedcentral.com)
  • This edition features a new section on cardiopulmonary bypass in neonates, infants, and children and a new chapter on circulatory support for minimally invasive cardiac surgery. (worldcat.org)
  • Although immunization can significantly reduce this risk, it is unknown how immunization status can be affected by cardiac surgery with cardiopulmonary bypass (CPB). (aappublications.org)
  • Most major congenital heart programs have strict guidelines for immunizations surrounding planned heart surgery in infants, although no real data exist as to what happens to vaccination status after surgery with cardiopulmonary bypass. (aappublications.org)
  • Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis of several postoperative complications. (mendeley.com)
  • Normal saline (placebo) was started in the operating room after induction of anesthesia and before heparinization, continued throughout the bypass period, and discontinued at the end of surgery. (clinicaltrials.gov)
  • Aminocaproic acid (an antifibrinolytic drug) was started in the operating room after induction of anesthesia and before heparinization, continued throughout the bypass period, and discontinued at the end of surgery. (clinicaltrials.gov)
  • To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery. (springer.com)
  • Pharmacodynamics of doxacurium during cardiac surgery with hypothermic cardiopulmonary bypass. (springer.com)
  • Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. (clinicaltrials.gov)
  • Our experience has confirmed that haemodialysis and haemofiltration in parallel with cardiopulmonary bypass are useful adjuncts in the perioperative management of patients with impaired renal function undergoing open heart surgery. (bmj.com)
  • Cardiopulmonary Bypass: A Primer was published by the cardiac surgery team at the University of Washington, using the iBook electronic format. (ctsnet.org)
  • Surgeons have often been reluctant to use cardiopulmonary bypass (CPB) during single (SLTx) and double lung (DLTx) transplantation surgery because of the potential adverse sequelae of CPB including haemorrhage and activation of complement leading to sequestration of neutrophils and platelets in the pulmonary capillary bed, endothelial damage, increased capillary permeability and pulmonary oedema. (ebscohost.com)
  • Discusses the use of leucocyte reduction filters in cardiopulmonary bypass (CPB) surgery. (ebscohost.com)
  • Paediatric patients undergoing open heart surgery utilising cardiopulmonary bypass to correct acyanotic congenital heart disease. (clinicaltrials.gov)
  • Patients with known organ dysfunction prior to surgery (pulmonary, renal or hepatic) Communication barrier resulting in poor basic comprehension of the proposed study (e.g. language barrier) Patients with cyanotic heart disease Patients undergoing heart surgery without the use of cardiopulmonary bypass Patients who do not tolerate oral Sildenafil (e.g. (clinicaltrials.gov)
  • Especially, cardiopulmonary bypass (CPB) during cardiovascular surgery, sustenance of the patient's life by providing an appropriate blood flow and oxygen supply to principal organs. (mdpi.com)
  • This study aimed to compare the release of S100B and NSE between cardiac surgery and interventional therapy for children and to investigate whether S100B serum concentration correlates with cardiopulmonary bypass in children. (ebscohost.com)
  • Cardiopulmonary bypass induces an ischaemia-reperfusion injury and systemic inflammatory response, which contributes to low cardiac output syndrome following cardiac surgery. (ebscohost.com)
  • Mini-extracorporeal circulation technology, conventional bypass and prime displacement in isolated coronary and aortic valve surgery: a propensity-matched in-hospital and survival analysis. (annals.org)
  • Objectives: The investigation centers on whether there is a reperfusion-induced specific cardiac inflammatory reaction after bypass surgery. (uni-muenchen.de)
  • In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for congenital heart surgery. (frontiersin.org)
  • Since the introduction of cardiopulmonary bypass (CPB) for congenital heart surgery in 1952, technology and techniques have greatly improved ( 1 ). (frontiersin.org)
  • To assess the benefits and harms of a higher versus lower blood pressure target during cardiac surgery with cardiopulmonary bypass (CPB). (cochrane.org)
  • For those of us who care for patients undergoing cardiac and thoracic surgery, cardiopulmonary bypass (CPB) can be a confusing and intimidating process that uses complex machinery and involves complicated and occasionally perplexing physiology. (asahq.org)
  • Cardiac surgery is associated with systemic inflammatory response, which is triggered by cardiopulmonary bypass (CPB) and possibly with underlying magnesium deficiency. (mdpi.com)
  • To determine the characteristics of neuromuscular block produced by two and three times the 95% effective dose (ED95) of doxacurium in patients undergoing coronary artery surgery with hypothermic cardiopulmonary bypass . (curehunter.com)
  • Prior to the advent of cardiopulmonary bypass, myocardial revascularization strategies fell into three categories: extracardiac procedures, cardiac operations on noncoronary artery structures, and direct coronary artery surgery. (springer.com)
  • Background: In cardiac surgery with cardiopulmonary bypass a complex systemic inflammatory response can arise postoperatively, causing serious complications such as the development of multi-organ dysfunction. (bibsys.no)
  • STUDY DESIGN: A prospective nested case-control study (n = 250) compared serial urinary proteomes of 22 patients with AKI and 22 patients without AKI before, during, and after cardiopulmonary bypass surgery. (biomedsearch.com)
  • The objective of this prospective, observational study with consecutive sampling was to assess the reliability, bias, and precision of Nellcor N-395 (N) and Masimo SET Radical (M) pulse oximeters in children with cyanotic congenital heart disease and children with congenital heart disease recovering from cardiopulmonary bypass-assisted surgery admitted to a cardiovascular operating suite and pediatric intensive care unit at a tertiary care community hospital. (ovid.com)
  • Four patients underwent off-pump cardiac surgery and 21 underwent on-pump cardiac surgery with a median cardiopulmonary bypass time of 85?minutes (interquartile range (IQR, 50-147). (degasperis.it)
  • OBJECTIVE: We have investigated the role of cardiopulmonary bypass on lactate metabolism in patients undergoing uncomplicated surgery for elective coronary artery bypass grafting (CABG). (inserm.fr)
  • Patients with ischaemic heart disease due to narrowing of coronary arteries can be treated with coronary artery bypass surgery. (cochrane.org)
  • Coronary artery bypass surgery has traditionally been performed with cardiopulmonary bypass and an arrested heart. (cochrane.org)
  • Systematic review of 86 randomised clinical trials including 10,716 patients and statistical analyses of the data showed that coronary artery bypass surgery performed on the beating heart results in an increased risk of death. (cochrane.org)
  • Our data raises a warning regarding coronary artery bypass surgery on the beating heart and cardiac arrest and cardiopulmonary bypass seem less risky. (cochrane.org)
  • In patients with contraindications for cannulation of the aorta and cardiopulmonary bypass coronary artery bypass surgery on the beating heart may be a solution but we need randomised clinical trials in these patients to identify the most beneficial approach. (cochrane.org)
  • 9 Patients with severe CHD require cardiopulmonary bypass surgery within the neonatal period. (ajnr.org)
  • Patients undergoing open-heart surgery procedures can be sustained using cardiopulmonary bypass equipment, by providing blood oxygenation and circulation to the brain and major organs while the patient's heart and lungs are temporarily bypassed. (pharmiweb.com)
  • This system allows surgeons to bypass a blocked coronary artery of the beating heart in a controlled operative environment, thereby reducing the complications caused due to this surgery. (pharmiweb.com)
  • Organ dysfunction after cardiopulmonary bypass (CPB) still is a major problem in patients undergoing cardiovascular surgery. (semanticscholar.org)
  • Improved outcomes during cardiac surgery: a multifactorial enhancement of cardiopulmonary bypass techniques. (pptaglobal.org)
  • Patients presenting for cardiac surgery with cardiopulmonary bypass (CPB) are more likely to have pre-existing comorbidities, which has resulted in a steady increase in the risk associated with CPB. (pptaglobal.org)
  • Hydroxyethyl Starch as a Priming Solution for Cardiopulmonary Bypass Impairs Hemostasis After Cardiac Surgery. (pptaglobal.org)
  • The thromboelastographic values indicated that HES solutions, when given in connection with the cardiopulmonary bypass prime, compromise hemostasis after cardiac surgery. (pptaglobal.org)
  • BACKGROUND: It is known that cardiopulmonary bypass (CPB) during cardiac surgery induces an inflammatory response. (rubicon-foundation.org)
  • Our hypothesis is that functional leukocyte adherence increases during and after cardiac surgery involving CPMATERIALS AND METHODS: Patients undergoing cardiac surgery with cardiopulmonary bypass are being recruited from the in-patient cardiothoracic surgery service. (rubicon-foundation.org)
  • Pre- and postoperative cardiopulmonary rehabilitation in hospitalized patients undergoing coronary artery bypass surgery: a randomized controlled trial. (semanticscholar.org)
  • article{Herdy2008PreAP, title={Pre- and postoperative cardiopulmonary rehabilitation in hospitalized patients undergoing coronary artery bypass surgery: a randomized controlled trial. (semanticscholar.org)
  • OBJECTIVE Patients who have to wait in the hospital for coronary artery bypass surgery (CABG) are exposed to the potential risks of immobilization. (semanticscholar.org)
  • Changes in functional capacity of patients two years after coronary artery bypass grafting surgery. (semanticscholar.org)
  • Effect of a preoperative intervention on preoperative and postoperative outcomes in low-risk patients awaiting elective coronary artery bypass graft surgery. (semanticscholar.org)
  • Myocardial ischemic reperfusion injury with cardiopulmonary bypass results in declining level of mir-499 expression in left ventricle myocardium of canines, suggesting mir-499 would be a potential therapeutic target in cardiac protection during open heart surgery. (biomedcentral.com)
  • Johnson D, Thomson D, Mycyk T, et al: Depletion of neutrophils by filter during aortopulmonary bypass surgery transiently improve cardiorespiratory status. (biomedcentral.com)
  • INTERPRETATION: Intraoperative corticosteroid use did not reduce the risk of acute kidney injury in patients with a moderate-to-high risk of perioperative death who had cardiac surgery with cardiopulmonary bypass. (ugent.be)
  • Our results do not support the prophylactic use of steroids during cardiopulmonary bypass surgery. (ugent.be)
  • Many thousands of these "blind" operations were performed until the introduction of cardiopulmonary bypass made direct surgery on valves possible. (wikipedia.org)
  • Therefore, during such surgery, the heart is temporarily stopped, and the patient is placed on cardiopulmonary bypass, meaning a machine pumps their blood and oxygen. (wikipedia.org)
  • Cardiopulmonary bypass was developed after surgeons realized the limitations of hypothermia in cardiac surgery: Complex intracardiac repairs take time, and the patient needs blood flow to the body (particularly to the brain), as well as heart and lung function. (wikipedia.org)
  • We sought to investigate the effect of multiple coronary artery bypass grafting (CABG) with or without cardiopulmonary bypass (CPB) on the perioperative inflammatory response. (nih.gov)
  • Coronary artery bypass grafting (CABG) without the heart lung machine has been possible for easily accessible targets such as the anterior descending or proximal right coronary. (unboundmedicine.com)
  • THERE is interest in the use of normothermic cardiopulmonary bypass in coronary artery bypass grafting (CABG) [1,2] because it is thought to offer better myocardial protection than standard hypothermic bypass. (asahq.org)
  • Because normothermic bypass obviates cerebral de-saturation during rewarming and may maintain normal capillary permeability, we studied patients having routine CABG under normothermic bypass (37 [degree sign] Celsius) with preoperative, immediate, and late MR scans. (asahq.org)
  • In contrast, we observed better long-term survival in the group of patients undergoing on-pump CABG with the use of cardiopulmonary bypass and cardioplegic arrest. (cochrane.org)
  • However, off-pump CABG may be acceptable when there are contraindications for cannulation of the aorta and cardiopulmonary bypass. (cochrane.org)
  • Coronary artery bypass grafting (CABG) is performed both without and with cardiopulmonary bypass, referred to as off-pump and on-pump CABG respectively. (cochrane.org)
  • AIM: Cardiopulmonary bypass (CPB), utilized in on-pump coronary artery bypass graft procedures (CABG) induces generalized immune suppression, release of heat shock proteins (HSP), inflammatory markers and apoptosis-specific proteins. (minervamedica.it)
  • In -this ret-ro-spec-tive -study, we -have exam-ined the inci-dence and the pre-dic-tors of -ARDS (-adult res-pir-a-to-ry dis-tress syn-drome), in -patients under-go-ing cor-o-nary -artery -bypass (-CABG) sur-gery on car-di-o-pul-mo-nary -bypass (CPB). (minervamedica.it)
  • This clinical trial was conducted to evaluate the effects of an in-hospital cardiopulmonary rehabilitation program performed before and after CABG on postoperative outcomes. (semanticscholar.org)
  • Pediatric cardiopulmonary bypass adaptati. (mendeley.com)
  • Pediatric cardiopulmonary bypass adaptations for long-term survival of baboons undergoing pulmonary artery replacement. (mendeley.com)
  • The chapter on pediatric cardiopulmonary bypass is interesting and informative. (lww.com)
  • Major differences adult and pediatric cardiopulmonary bypass (CPB) stem from anatomic, metabolic, and physiologic differences in these 2 groups of patients. (medscape.com)
  • Jennifer K. Lee, R. Blaine Easley and Kenneth M. Brady, " Neurocognitive Monitoring and Care During Pediatric Cardiopulmonary Bypass - Current and Future Directions", Current Cardiology Reviews (2008) 4: 123. (eurekaselect.com)
  • It is now well-established that AKI is a serious and common complication following cardiopulmonary bypass (CPB) in both children and adults, adverse outcomes may occur in the short term as well as long term, with higher incidence of chronic kidney disease, increased healthcare utilization and higher frequency of cardiovascular events in patients who develop post-CPB AKI. (frontiersin.org)
  • It is now well-established that AKI is a serious and common complication following cardiopulmonary bypass (CPB) in both children and adults, leading to worse outcomes and higher mortality ( 1 - 3 ). (frontiersin.org)
  • Postoperative cognitive dysfunction (POCD) is a common complication following cardiopulmonary bypass (CPB). (spandidos-publications.com)
  • While variable, most pediatric studies report an incidence of 30-50%, with higher rates in neonates, more complex surgeries, and longer cardiopulmonary bypass times ( 2 - 5 ). (frontiersin.org)
  • Global Cardiopulmonary Bypass Equipment Industry 2021 Market Research Report analysed the current state in the definitions, classifications, applications and industry chain structure. (beforeitsnews.com)
  • Global Cardiopulmonary Bypass Equipment Industry 2021 Market Research Report is a professionally prepared report comprising of in-depth information as well as knowledge which is helpful to the new entrants and the established players. (beforeitsnews.com)
  • Furthermore, each and every important variable which is responsible for shaping the Global Cardiopulmonary Bypass Equipment Industry in the incorporated during the preparation process of the report. (beforeitsnews.com)
  • Future Development Trends in the Global Cardiopulmonary Bypass Equipment Company through the market share, SWOT analysis, revenue, gross margin is indicated through the report. (beforeitsnews.com)
  • The competitive landscape of the market state showcases the study of the most renowned players in the China markets in the field of Global Cardiopulmonary Bypass Equipment industry. (beforeitsnews.com)
  • Through the report, the new entrants are able to get the complete overview of the current state of the Global Cardiopulmonary Bypass Equipment which will be beneficial for them. (beforeitsnews.com)
  • The Global Cardiopulmonary Bypass Equipment Market , by Product Type (Single Roller Pump and Double Roller Pump), By End User (Hospitals and Ambulatory Surgical Centers), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa), was valued at US$ 111.33 million in 2017 and is projected to exhibit a CAGR of 1.2% over the forecast period (2018 - 2026). (pharmiweb.com)
  • The global cardiopulmonary bypass equipment market growth is driven by rising incidence of cardiovascular and respiratory disorders. (pharmiweb.com)
  • The global cardiopulmonary bypass equipment market is expected to exhibit a CAGR of 1.2% during the forecast period (2018 - 2026). (pharmiweb.com)
  • Abstract: Objective: Cardiopulmonary bypass (CPB) support is required in some lung transplantation (LTX) operations. (ebscohost.com)
  • axillofemoral bypass insertion of a vascular prosthesis or section of saphenous vein from the axillary artery to the ipsilateral femoral artery to relieve lower limb ischemia in patients in whom normal anatomic placement of a graft is contraindicated, as by abdominal infection or aortic aneurysm. (thefreedictionary.com)
  • Using cardiopulmonary bypass, the patient underwent resection of the aortic cusps, debridement of the aortic root, septal and anterior leaflets of the tricuspid valve, and the membranous septum. (degasperis.it)
  • roviding cardiopulmonary bypass and surgical back-up for transcatheter aortic valve implantation has significant implications for surgical services. (bjcardio.co.uk)
  • The provision of cardiopulmonary bypass (CPB) equipment and cardiothoracic (CT) surgical back-up during transcatheter aortic valve implantation (TAVI) has major implications for surgical services. (bjcardio.co.uk)
  • The aim of this investigation was to assess organ injury provoked by a new pulsatile pump for cardiopulmonary bypass (CPB) with respect to a conventional centrifugal pump. (cun.es)
  • Several potent mediators are released into plasma, capable of causing harmful effects to different organs, contributing to postoperative morbidity after operations using cardiopulmonary bypass. (diva-portal.org)
  • BACKGROUND: Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion. (uzh.ch)
  • To provide a brief review of the development of cardiopulmonary bypass. (scielo.br)
  • Many of the studies conducted at this time laid the foundation for the future development of cardiopulmonary bypass (CPB). (scielo.br)
  • In the control group minimal red cell fragmentation (2-3/10 hpf) was seen, while acanthrocytes were present only during and immediately after cardiopulmonary bypass. (annals.org)
  • The Nellcor N-395 pulse oximeter failed more often immediately after cardiopulmonary bypass than did the Masimo SET Radical pulse oximeter. (ovid.com)
  • [ 65 ] In a comparative analysis study of 10 patients undergoing cardiopulmonary bypass, three different methods of the ACT test were compared with ECT. (medscape.com)
  • Methods: In 12 patients receiving coronary bypass grafts, arterial and coronary venous blood was obtained before onset of CPB, and 1, 5, 10, 25, 35 and 75 min after cardiac reperfusion. (uni-muenchen.de)
  • Replacing cardiopulmonary bypass with extracorporeal membrane oxygenation in lung transplantation operations Bittner, Hartmuth B. (ebscohost.com)
  • The advancement of extracorporeal circulation techniques has played an essential role in minimizing the complications of cardiopulmonary bypass, which can range from various degrees of tissue injury to multiple organ dysfunction syndrome. (scielo.br)
  • Description Cardiopulmonary bypass is a procedure that temporarily substitutes a patients' heart and lung functions with an extracorporeal heart-lung machine. (rutgers.edu)
  • Thurlow PJ, Doolan L, Sharp R, et al: Laboratory studies of the effect of Pall extracorporeal leucocyte filters LG6 and AV6 on patients undergoing coronary bypass grafts. (biomedcentral.com)
  • Several studies-for example, the Evaluation of Patients During Coronary Artery Bypass Graft Operation: Linking Utilization of Bivalirudin to Improved Outcomes and New Anticoagulant Strategies (EVOLUTION-ON) and the Coronary Artery Bypass Grafting Heparin-Induced Thrombocytopenia Thrombosis Syndrome On- and Off-Pump Safety and Efficacy (CHOOSE-ON) trials-propose a reliable therapeutic protocol for bivalirudin. (medscape.com)
  • Reston JT, Tregear SJ, Turkelson CM. Meta-analysis of short-term and mid-term outcomes following off-pump coronary artery bypass grafting. (medtronic.com)
  • External inlet and outlet pinch-type plate valves for controlling the blood flow through a compressible shunt of a cardiopulmonary bypass pump wherein the valves are not fixedly connected to the compression chamber or housing of the pump so that the distance between the inlet and outlet valves can be adjusted to thereby allow adjustment of stroke volume to fit the needs of the patient being treated. (freepatentsonline.com)
  • 7. A cardiopulmonary bypass pump according to claim 5, wherein a counterweight is mounted on the upper flat plate of the inlet valve to facilitate the pivotal movement of the upper flat plate to the closed position. (freepatentsonline.com)
  • An externally valved shunt for a cardiopulmonary bypass pump is disclosed in U.S. Pat. (freepatentsonline.com)
  • How should I prepare the pump on the machine used for cardiopulmonary bypass? (mhaus.org)
  • An in vitro cardiopulmonary bypass roller pump model was used, so that the influence of single factors could be studied. (bibsys.no)
  • Møller CH, Penninga L, Wetterslev J, Steinbrüchel DA, Gluud C. Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease. (cochrane.org)
  • This is due to the shift in trend towards the adoption of technologically advanced less invasive operating equipment, Off-Pump Coronary Artery Bypass (OPCAB) Beating Heart System. (pharmiweb.com)
  • A wide range of pharmacological, surgical, and mechanical pump approaches have been studied to attenuate the systemic inflammatory response to cardiopulmonary bypass, yet no systematically‐based review exists to cover the scope of anti‐inflammatory interventions deployed. (uwi.edu)
  • Every single component of the cardiopulmonary bypass (CPB) circuitry is equally important for generating adequate quality of pulsatility, not only the pump. (elsevier.com)
  • In July 1952, Forest Dodrill was the first to use a mechanical pump in a human to bypass the left side of the heart whilst allowing the patient's lungs to oxygenate the blood, in order to operate on the mitral valve. (wikipedia.org)
  • The development of external cardiopulmonary-cerebral resuscitation (CPCR) was initiated by one of the co-inventors herein, Dr. Peter Safar. (google.co.uk)
  • extracranial/intracranial bypass anastomosis of the superficial temporal artery to the middle cerebral artery to preserve function or prevent stroke or death in patients with stenosis of the internal carotid or middle cerebral artery. (thefreedictionary.com)
  • Aprotinin protects the cerebral microcirculation during cardiopulmonary bypass. (ebscohost.com)
  • Although the benefits to the myocardium are generally accepted, there is conflicting data on cerebral damage after normothermic bypass. (asahq.org)
  • It is likely, therefore, that the brain suffers some insults during bypass, and the use of hypothermia to provide cerebral protection has been advocated. (asahq.org)
  • In a previous study we found that in each of six patients magnetic resonance (MR) images obtained within 1 h of the end of hypothermic bypass (immediate images) showed marked cerebral swelling that had returned to normal after 1 week. (asahq.org)
  • Cerebral ischemia due to microemboli or macroemboli, systemic inflammatory response, and cerebral hypoperfusion during cardiopulmonary bypass (CPB) causes impairment in the blood brain barrier. (powershow.com)
  • This innovation will improve the survival rate of cardiopulmonary cerebral resuscitation. (nii.ac.jp)
  • AmSECT : Blogs : Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring. (amsect.org)
  • Optimal blood pressure during cardiopulmonary bypass defined by cerebral autoregulation monitoring. (amsect.org)
  • We sought to define the lower and upper limits of cerebral blood flow autoregulation and the optimal blood pressure during cardiopulmonary bypass. (amsect.org)
  • Recent success using emergency percutaneous cardiopulmonary bypass as a tool for resuscitation from cardiac arrest is very encouraging. (nii.ac.jp)
  • Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children. (ahajournals.org)
  • Bradykinin was measured by radioimmunoassay in blood samples obtained before, during and after profound hypothermia (to 18 degrees C) and cardiopulmonary bypass. (ahajournals.org)
  • Despite the constant evolution of cardiopulmonary bypass techniques and attempts to minimize their complications, it is still essential that clinicians respect the particularities of each patient's physiological function. (scielo.br)
  • Acute renal injury is one of the most frequent complications after cardiopulmonary bypass (CPB). (nih.gov)
  • Does Sildenafil Protect Against Pulmonary Related Complications Following Cardiopulmonary Bypass? (clinicaltrials.gov)
  • A Randomised, Double-Blind, Placebo-Controlled, Single-Centre Study of the Pre-Operative Effect of Sildenafil Citrate on Pulmonary Related Complications Following Cardiopulmonary Bypass in Children Undergoing Cardiac Surgical Repair. (clinicaltrials.gov)
  • [5] There are many opportunities for adverse complications to occur during bypass. (asahq.org)
  • By avoiding cardiac arrest and cardiopulmonary bypass, it was hoped that complications seen after coronary artery bypass could be reduced. (cochrane.org)
  • The so-called cardiopulmonary bypass (CPB) is related to complications like stroke or hypoxia. (dantecdynamics.com)
  • Patients undergoing isolated coronary artery bypass grafting were sequentially randomized to conventional CPB (control group, n? (degasperis.it)
  • We investigated the influence of hydroxyethyl starch (HES) as a priming solution for the cardiopulmonary bypass (CPB) circuit on postoperative hemostasis in 45 patients undergoing elective coronary artery bypass grafting. (pptaglobal.org)
  • After local ethical committee approval, 20 patients undergoing coronary artery bypass grafting using CPB were prospectively randomly allocated to have either a Leukogard LG-6 (Pall Biomedical, Portsmouth, UK) or a nonleucocyte depleting filter inserted into the arterial line of the CPB circuit. (biomedcentral.com)
  • Super-high oxygen (O2) levels are often used in the bypass circuit after the cross-clamp is released. (gla.ac.uk)
  • This comprehensive, multidisciplinary text covers all aspects of cardiopulmonary bypass including sections on equipment, physiology and pathology, hematologic aspects, and clinical applications. (worldcat.org)
  • The editor, Dr. Nahush Mokadam , has structured the publication in a very logical format, with chapters describing the circuit components, technical aspects of cardiopulmonary support, myocardial protection, nursing principles, anesthesia management, troubleshooting, and finally a brief summary of the history of cardiopulmonary bypass. (ctsnet.org)
  • Emergency cardiopulmonary bypass (ECPB - artificial heart and lung outside the patients body) is a method which has shown good results in case reports and animal studies for cardiac arrest care. (clinicaltrials.gov)
  • Emergency Cardiopulmonary Bypass (ECPB) would be such a treatment option for these heavily compromised patients, as it has shown considerably good results used as resuscitation device for cardiac arrest in animal studies. (clinicaltrials.gov)
  • Aim of this study: To compare current standard therapy for patients after out of hospital cardiac arrest (cardiopulmonary resuscitation until return of spontaneous circulation or termination of efforts) with a new concept of transportation with ongoing cardiopulmonary reanimation and installation of ECPB at the Emergency Department to improve survival. (clinicaltrials.gov)
  • Development of cardiac stabilisers have made it possible to conduct the operation on the beating heart and thereby avoid cardiac arrest and cardiopulmonary bypass. (cochrane.org)
  • During a period of cardiac arrest of 15 to 30 min, dogs were supported with the manually operated cardiopulmonary bypass. (nii.ac.jp)
  • Background: Cardiopulmonary bypass (CPB) leads to systemic inflammation. (uni-muenchen.de)
  • Cardiopulmonary bypass induced inflammation: Pathophysiology and treatment. (mendeley.com)
  • Nitric oxide administration during paediatric cardiopulmonary bypass: a randomised controlled trial. (ebscohost.com)
  • Fibrinogen concentrate supplementation during paediatric cardiopulmonary bypass may decrease the incidence and severity of postoperative bleeding, and reduce the need for transfusion of blood and ancillary blood products (platelets, fresh frozen plasma, and cryoprecipitate). (isrctn.com)
  • One minor weakness is the lack of a discussion of "normothermic" bypass in the chapter covering temperature management (this subject is addressed somewhat in the chapter on the neurologic effects of CPB). (asahq.org)
  • The chapter on renal considerations, dialysis, and ultrafiltration during bypass is also a nice general review of current practices in the cardiac operating room. (lww.com)
  • hepatorenal bypass insertion of a vascular prosthesis between the common hepatic artery and the renal artery, serving as a passage around an occluded segment of renal artery. (thefreedictionary.com)
  • Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 expression. (nih.gov)
  • Experimental amitriptyline poisoning: treatment of severe cardiovascular toxicity with cardiopulmonary bypass. (nih.gov)
  • MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still unknown. (biomedcentral.com)
  • extra-anatomic bypass an arterial bypass that does not follow the normal anatomic pathway, such as an axillofemoral bypass. (thefreedictionary.com)
  • Arterial filter bypass loop: what occurs in this area during cardiopulmonary bypass and are there potential patient implications. (semanticscholar.org)
  • Arterial limb blood samples were taken immediately after institution of CPB (0min) and at 10-min intervals throughout the bypass period. (biomedcentral.com)
  • Increasingly complex repairs subsequently became possible with the refinement of cardiopulmonary bypass (CPB) techniques and the use of hypothermic circulatory arrest that Barratt-Boyes et al (1971) and Castaneda et al (1974) popularized. (medscape.com)
  • This monograph is a compendium of 12 subject areas related to cardiopulmonary bypass and was edited by a perfusionist with contributions from industry, multiple perfusionists, surgeons, and one anesthesiologist. (lww.com)
  • Although we are well aware of the techniques for establishing, maintaining, and discontinuing cardiopulmonary bypass, we surgeons are sometimes unaware of all the work that goes on across the "blood brain barrier. (ctsnet.org)
  • One of my surgeons had to put a patient on Cardiopulmonary Bypass for another surgeon doing a Nephrectomy & I cannot for the life of me find a stand alone code. (aapc.com)
  • To compare cardiopulmonary bypass (CPB) with more conventional therapy in the treatment of severe amitriptyline poisoning. (nih.gov)
  • Cardiopulmonary Bypass: Principles and Practice , 3rd Edition, does an outstanding job of explaining both the mechanical and physiologic process of CPB. (asahq.org)
  • If return of spontaneous circulation under competent cardiopulmonary resuscitation (CPR) measures is not achieved within the first 25 minutes the chance of survival decreases even further. (clinicaltrials.gov)
  • The `ECPB´ group will receive ongoing cardiopulmonary resuscitation during transport to the emergency department where ECPB will be installed. (clinicaltrials.gov)
  • To facilitate this time consuming process, we developed a manually operated portable cardiopulmonary bypass system for emergency resuscitation. (nii.ac.jp)
  • Mass spectrometry-based proteomic analysis of urine in acute kidney injury following cardiopulmonary bypass: a nested case-control study. (biomedsearch.com)
  • A new cardiopulmonary bypass circuit with reduced foreign su. (lww.com)
  • The direct contact of the patient's blood with the foreign surface of the cardiopulmonary bypass (CPB) circuit plays an important role in triggering this response [1] . (lww.com)
  • In 19 patients with heparin-coated cardiopulmonary bypass equipment the levels were significantly reduced, indicating improved biocompatibility of the cardiopulmonary bypass circuit. (diva-portal.org)
  • Publications] Tajiri A, et al: 'A manually operated portable cardiopulmonary bypass circuit with two self inflating reservoir-pumps. (nii.ac.jp)
  • Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition of the abnormal environment of the heart-lung machine. (clinicaltrials.gov)
  • Median sternotomy for double lung transplantation with cardiopulmonary bypass in seven consecutive patients. (ebscohost.com)
  • We describe our technique of using median sternotomy to perform double lung transplantations with cardiopulmonary bypass. (ebscohost.com)
  • With the onset of cardiopulmonary bypass and hence, removal of the lung and pulmonary converting enzyme from the circulation, there was a further rise in the already elevated concentrations of bradykinin. (ahajournals.org)
  • Does pre-operative administration of Sildenafil (Viagra, Pfizer) reduce the lung injury associated with cardiopulmonary bypass in children undergoing corrective surgical repair of congenital heart disease. (clinicaltrials.gov)
  • Following cardiopulmonary bypass (CPB), the incidence rates of short-term cognitive abnormalities, memory and learning ability decline and visual-motor response declines by 60-80% ( 1 ). (spandidos-publications.com)
  • These were performed epicardially, on the beating heart, without cardiopulmonary bypass or median sternotomy. (wikipedia.org)
  • citation needed] Today, the terms "minimaze", "mini-maze", and "mini maze" are still sometimes used to describe open heart procedures requiring cardiopulmonary bypass and median sternotomy, but more commonly they refer to minimally invasive, epicardial procedures not requiring cardiopulmonary bypass, such as those developed by Saltman, Wolf, and others. (wikipedia.org)
  • In seven patients undergoing coronary bypass, heparin-coated circuits were used (group HC), and seven served as control patients (group C). In group HC the heparin dose was reduced to 75% (225 IU/kg). (diva-portal.org)
  • Cardiopulmonary Bypass with Low- Versus High-Priming Volume: Comparison of Inflammatory Responses in a Rat Model. (semanticscholar.org)
  • Spire St Anthony's Hospital is donating two cardiopulmonary bypass machines to the Family Hospital, Ghana and the International Hospital of Uganda where our surgical RMO, Dr Clement Akomea-Agyin works. (spirehealthcare.com)
  • We found that bypass was available in the catheter lab in 94% of Edwards versus 30% of CoreValve centres (p=0.0003), and that a full surgical team and theatre were kept free in 89% of Edwards versus 20% of CoreValve centres (p=0.008). (bjcardio.co.uk)
  • The anticoagulation regime used during cardiopulmonary bypass was lepirudin based. (ebscohost.com)
  • Background: Accurate control of heparin anticoagulation is necessary during all stages of cardiopulmonary bypass (CPB). (ebscohost.com)
  • Activated clotting time (ACT) is used routinely to monitor anticoagulation with unfractionated heparin in patients undergoing cardiopulmonary bypass (CPB). (perfusion.com)