Solutions which, upon administration, will temporarily arrest cardiac activity. They are used in the performance of heart surgery.
A procedure to stop the contraction of MYOCARDIUM during HEART SURGERY. It is usually achieved with the use of chemicals (CARDIOPLEGIC SOLUTIONS) or cold temperature (such as chilled perfusate).
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
The hollow, muscular organ that maintains the circulation of the blood.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
A heterogenous group of inherited disorders characterized by recurring attacks of rapidly progressive flaccid paralysis or myotonia. These conditions have in common a mutation of the gene encoding the alpha subunit of the sodium channel in skeletal muscle. They are frequently associated with fluctuations in serum potassium levels. Periodic paralysis may also occur as a non-familial process secondary to THYROTOXICOSIS and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1481)
Those individuals engaged in research.
The misinterpretation of a real external, sensory experience.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation.
The main trunk of the systemic arteries.
Catheters designed to be left within an organ or passage for an extended period of time.
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
The veins and arteries of the HEART.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Authors' withdrawal or disavowal of their participation in performing research or writing the results of their study.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The study of the heart, its physiology, and its functions.
Time period from 1601 through 1700 of the common era.
The dorsal portion or roof of the midbrain which is composed of two pairs of bumps, the INFERIOR COLLICULI and the SUPERIOR COLLICULI. These four colliculi are also called the quadrigeminal bodies (TECTUM MESENCEPHALI). They are centers for visual sensorimotor integration.
Time period from 1701 through 1800 of the common era.
Resinous substances which most commonly originate from trees. In addition to resins, they contain oils, cinnamic acid and BENZOIC ACID.
Oil obtained from seeds of Ricinus communis that is used as a cathartic and as a plasticizer.
A plant genus in the family PINACEAE, order Pinales, class Pinopsida, division Coniferophyta. Balm of Gilead is a common name more often referring to POPULUS and sometimes to COMMIPHORA.
Common name for Ricinus communis, a species in the family EUPHORBIACEAE. It is the source of CASTOR OIL.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
The services rendered by members of the health profession and non-professionals under their supervision.

Myocardial protection: the rebirth of potassium-based cardioplegia. (1/132)

The introduction of open-heart surgery more than 4 decades ago signaled a new era in medicine. For the 1st time, previously untreatable cardiac anomalies became amenable to surgical therapy. The use of the heart-lung machine seemed to grant the surgeon unlimited time in which to operate inside the heart. Still frustrated by poor operating conditions and the threat of air embolism, Denis Melrose introduced elective cardiac arrest in 1955. His use of a potassium citrate solution seemed to offer a safe method to effect a quiet, bloodless field. However, a few years after its inception, numerous reports began to question the safety of this approach, and the Melrose technique was abandoned in the early 1960s. Nearly 15 years elapsed before potassium-based cardioplegia regained popularity. During this period, topical hypothermia, coronary perfusion with intermittent aortic occlusion, and normothermic ischemia were evaluated and discarded. A few European investigators like Hoelscher, Bretschneider, and Kirsch had maintained their interest in chemical cardioplegia, and it was through their efforts that future researchers like Hearse and Gay spearheaded the return to potassium-based cardioplegia, which today forms the core of the cardiac surgeon's myocardial protective armamentarium and has contributed towards lowering operative mortality rates.  (+info)

Induction of immune tolerance in adult rabbits undergoing heterotopic cardiac transplantation. (2/132)

OBJECTIVE: To induce experimental immune tolerance in rabbits and observe its effects on heterotopic cardiac transplantation. METHODS: Donor's splenic lymphocytes pretreated with platinum metal chelator were injected into the recipient's mesenteric-portal vein. Cyclosporin A was perfused through the donor's heart. RESULTS: The injection of donor's splenic lymphocytes before transplantation could significantly prolong the survival time of the heterotopically transplanted heart. The effect of two injections was better than that of one. Radioactive tracer studies showed that the 99mTc-HMPAO tagged lymphocytes injected into the recipient rabbit were later concentrated in the liver, though initially they were distributed in multiple organs. The induced immune tolerance was antigen-specific, and it neither affect the other immune functions of the lymphatic system prominently nor exert any harmful effect on the recipient's liver and renal functions. The perfusion of cyclosporin A through the donor heart could block the glycosyl groups, such as D-glucose, D-mannose or N-acetyl-galactosamine on the surface of the myocardial cells, thus might change the antigenic expression, effectively preventing rejection of the graft by the host, and might be considered as a new method to block graft rejection in cardiac transplantation. The combined use of the above-mentioned two methods acted on both the host and the donor, thus reducing the exposed antigens on the donor organ as well as the immune reaction against the donor antigens, and resulting in synergistic effect in inducing immune tolerance in adult rabbits, and resulting in relatively long-term survival of transplanted hearts. CONCLUSION: This report may provide the experimental basis for inducing immune tolerance in clinical transplantation.  (+info)

Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus. (3/132)

Although fibrinolysis has improved survival of patients after myocardial infarction (MI), such therapy is less likely to be administered to patients with diabetes. Furthermore, these patients present later (15 min) than nondiabetics. Moreover, even with the use of early potent fibrinolytic agents, patients with diabetes continued to suffer excessive morbidity and mortality. This finding is not related to the ability of fibrinolytic agents to restore complete reperfusion or increased risk of reocclusion of the infarct-related artery. Instead, the impaired ventricular performance at the noninfarct areas and metabolic derangements during the acute phase of MI may account for the adverse outcome. The efficacy of percutaneous coronary revascularization procedures for treatment of acute MI requires further evaluation. Therapeutic approaches should consider correcting these abnormalities to afford greater survival benefit for this subset of high-risk patients.  (+info)

Intercalated clear cells or pale cells in the sinus node of canine hearts? An ultrastructural study. (4/132)

Two types of sinus nodal cells were responsible for the main differences in the literature concerning the ultrastructure of the sinuatrial node: the intercalated clear cells and pale cells. Canine hearts were arrested by (1) aortic cross clamping, (2) coronary perfusion with the cardioplegic solution St. Thomas, and (3) coronary perfusion with the cardioplegic solution HTK (Custodiol(R)). After fixation by immersion or perfusion the sinus node tissue was prepared for electron microscopy. Following cardioplegic arrest and perfusion fixation, three nodal cell types in the non-ischemic sinuatrial node were observed: typical nodal cells, transitional cells, and intercalated clear cells. Less than 1% of the non-ischemic sinuatrial cells were intercalated clear cells, surrounded by typical nodal cells or transitional cells. The contractile apparatus of the intercalated clear cells was extremely poorly developed. Great structural variations in the mitochondria were observed in intercalated clear cells, variations that would not appear under conditions of ischemia. In contrast, after 15-25 min of ischemia at 25 degrees C the appearance of the sinus nodal cells was strikingly different from that of the non-ischemic sinuatrial cells. More than 10% of the nodal cells showed typical ischemic alterations, e.g., mitochondrial swelling, clumping of nuclear chromatin, loss of glycogen particles, and cell swelling in varying degrees. Because they look very pale, these nodal cells have been described as pale cells in the literature. Intercalated clear cells appear mainly in non-ischemic nodal tissue. Pale cells are ischemically damaged sinus nodal cells.  (+info)

Reduced cytosolic Ca(2+) loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts. (5/132)

BACKGROUND: Hypothermia is cardioprotective, but it causes Ca(2+) loading and reduced function on rewarming. The aim was to associate changes in cytosolic Ca(2+) with function in intact hearts before, during, and after cold storage with or without cardioplegia (CP). METHODS AND RESULTS: Guinea pig hearts were initially perfused at 37 degrees C with Krebs-Ringer's (KR) solution (in mmol/L: Ca(2+) 2.5, K(+) 5, Mg(2+) 2.4). One group was perfused with CP solution (Ca(2+) 2.5, K(+) 18, Mg(2+) 7.2) during cooling and storage at 3 degrees C for 4 hours; another was perfused with KR. LV pressure (LVP), dP/dt, O(2) consumption, and cardiac efficiency were monitored. Cytosolic phasic [Ca(2+)] was calculated from indo 1 fluorescence signals obtained at the LV free wall. Cooling with KR increased diastolic and phasic [Ca(2+)], whereas cooling with CP suppressed phasic [Ca(2+)] and reduced the rise in diastolic [Ca(2+)]. Reperfusion with warm KR increased phasic [Ca(2+)] 86% more after CP at 20 minutes and did not increase diastolic [Ca(2+)] at 60 minutes, compared with a 20% increase in phasic [Ca(2+)] after KR. During early and later reperfusion after CP, there was a 126% and 50% better return of LVP than after KR; during later reperfusion, O(2) consumption was 23% higher and cardiac efficiency was 38% higher after CP than after KR. CONCLUSIONS: CP decreases the rise in cardiac diastolic [Ca(2+)] observed during cold storage in KR. Decreased diastolic [Ca(2+)] and increased systolic [Ca(2+)] after CP improves function on reperfusion because of reduced Ca(2+) loading during and immediately after cold CP storage.  (+info)

Leukocyte-depleted continuous blood cardioplegia for coronary artery bypass grafting. (6/132)

Many cardiac surgeries are performed with blood cardioplegia. However, some studies suggest that activated neutrophils form blood cardioplegia can cause reperfusion injury. In this study we assessed myocardial protection using a leukocyte-depleted cardioplegic solution. Patients undergoing elective coronary artery bypass grafting (CABG) with continuous blood cardioplegia were divided into two groups: the LD group, which received leukocyte-depleted blood cardioplegia (n = 11); and the control group, which received nonfiltered blood cardioplegia (n = 11). IL-6, IL-8, CK-MB, and troponin T were measured in the coronary sinus blood immediately after the release of the aortic cross-clamp. Cytokine concentrations were also measured upon the patient's return to the ICU. The total dopamine and dobutamine doses, hemodynamic measurements after surgery, and the leukocyte filtration rate were also measured. During antegrade cardioplegia infusion, leukocytes were almost completely removed (filtration rate: 85.8+/-4.0%). However, during terminal warm cardioplegia, leukocyte removal decreased (filtration rate: 39.9+/-7.8%). Immediately after the release of the aortic cross-clamp, plasma CK-MB and troponin T concentrations were significantly lower in the LD group (17.7+/-1.9 U/l and 0.017+/-0.002 ng/ml, respectively) than in the control group (30.3+/-3.6 U/l and 0.072+/-0.029 ng/ml, respectively). The IL-6 and IL-8 concentrations were similar in the LD group and the control group. After the return to the ICU, the CK-MB and troponin T concentrations were similar in the two groups. No significant differences were found in the total doses of dopamine or dobutamine after surgery in the two groups (99+/-77 vs 101+/-128 microg/kg/min). No significant differences were found in the hemodynamic parameters after surgery in the two groups. In patients undergoing CABG with continuous blood cardioplegia, leukocyte-depleted blood cardioplegic solution may attenuate reperfusion injury.  (+info)

Does cardioplegia type affect outcome and survival in patients with advanced left ventricular dysfunction? Results from the CABG Patch Trial. (7/132)

BACKGROUND: There is controversy regarding which cardioplegic solution, temperature, and route of administration provides superior protection. The CABG Patch Trial enrolled a high-risk group of coronary artery disease patients with an ejection fraction of <36%. Thus, they constitute an ideal group to benefit most from optimal cardioplegic protection. METHODS AND RESULTS: All patients randomized into the trial were compared with respect to the use of blood and crystalloid cardioplegia. In addition, a questionnaire was sent to surgeons requesting blood cardioplegic temperature and route. Patients receiving crystalloid cardioplegia versus those receiving blood cardioplegia were found to have significantly more operative deaths (2% versus 0.3%, P:=0.02), postoperative myocardial infarctions (10% versus 2%, P:<0.001), shock (13% versus 7%, P:=0. 013), and postoperative conduction defects (21.6% versus 12.4%, P:=0. 001). Despite this, early death (6% crystalloid versus 4% blood cardioplegia) and late death (24% crystalloid versus 21% blood cardioplegia) statistics were not significantly different. Patients receiving normothermic blood had less postoperative right ventricular dysfunction (10%) than did patients receiving cold blood (25%) or cold blood with warm reperfusion (30%) (P:=0.004). There was no significant difference in early or late death. Finally, patients who received combined antegrade and retrograde cardioplegia had significantly less inotrope use (71% versus 84%, P:=0.002), right ventricular dysfunction (23% versus 41%, P:=0.001), and postoperative balloon pump use (12% versus 19%, P:=0.02) than did those who received antegrade cardioplegia. There was no difference in survival. CONCLUSIONS: Blood cardioplegia and combined antegrade and retrograde cardioplegia are superior to crystalloid and antegrade cardioplegia alone for postoperative morbidity. Despite this, there is no significant difference in early or late survival.  (+info)

Cardioplegic strategies for calcium control: low Ca(2+), high Mg(2+), citrate, or Na(+)/H(+) exchange inhibitor HOE-642. (8/132)

BACKGROUND: Ca(2+) overload plays an important role in the pathogenesis of cardioplegic ischemia-reperfusion injury. The standard technique to control Ca(2+) overload has been to reduce Ca(2+) in the cardioplegic solution (CP). Recent reports suggest that Na(+)/H(+) exchange inhibitors can also prevent Ca(2+) overload. We compared 4 crystalloid CPs that might minimize Ca(2+) overload in comparison with standard Mg(2+)-containing CP: (1) low Ca(2+) CP (0.25 mmol/L), (2) citrate CP/normal Mg(2+) (1 mmol/L Mg(2+)), (3) citrate CP/high Mg(2+) (9 mmol/L Mg(2+)), and (4) the addition of the Na(+)/H(+) exchange inhibitor HOE-642 (Cariporide). We also tested the effect of citrate titration in vitro on the level of free Ca(2+) and Mg(2+) in CPs. METHODS AND RESULTS: Isolated working rat heart preparations were perfused with oxygenated Krebs-Henseleit buffer and subjected to 60 minutes of 37 degrees C arrest and reperfusion with CPs with different Ca(2+) concentrations. Cardiac performance, including aortic flow (AF), was measured before and after ischemia. Myocardial high-energy phosphates were measured after reperfusion. The in vitro addition of citrate to CP (2%, 21 mmol/L) produced parallel reductions in Mg(2+) and Ca(2+). Because only Ca(2+) was required to be low, the further addition of Mg(2+) increased free Mg(2+), but the highest level achieved was 9 mmol/L. Citrate CP significantly impaired postischemic function (AF 58.3+/-2. 5% without citrate versus 41.6+/-3% for citrate with normal Mg(2+), P:<0.05, versus 22.4+/-6.2% for citrate with high Mg(2+), P:<0.05). Low-Ca(2+) CP (0.25 mmol/L Ca(2+)) significantly improved the recovery of postischemic function in comparison with standard CP (1.0 mmol/L Ca(2+)) (AF 47.6+/-1.7% versus 58.3+/-2.5%, P:<0.05). The addition of HOE-642 (1 micromol/L) to CP significantly improved postischemia function (47.6+/-1.7% without HOE-642 versus 62.4+/-1. 7% with HOE-642, P:<0.05). Postischemia cardiac high-energy phosphate levels were unaffected by Ca(2+) manipulation. CONCLUSIONS: (1) A lowered Ca(2+) concentration in CP is beneficial in Mg(2+)-containing cardioplegia. (2) The use of citrate to chelate Ca(2+) is detrimental in the crystalloid-perfused isolated working rat heart, especially with high Mg(2+). (3) The mechanism of citrate action is complex, and its use limits precise simultaneous control of Ca(2+) and Mg(2+). (4) HOE-642 in CP is as efficacious in preservation of the ischemic myocardium as is the direct reduction in Ca(2+).  (+info)

Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious hemodynamic effects ...
OBJECTIVE: Depolarizing potassium cardioplegia has been increasingly linked to left ventricular dysfunction, arrhythmia, and microvascular damage. We tested a new polarizing normokalemic cardioplegic solution employing adenosine and lidocaine as the arresting, protecting, and preserving cardioprotective combination. Adenosine hyperpolarizes the myocyte by A1 receptor activation, and lidocaine blocks the sodium fast channels. METHODS: Isolated perfused rat hearts were switched from the working mode to the Langendorff (nonworking) mode and arrested for 30 minutes, 2 hours, or 4 hours with 200 µmol/L adenosine and 500 µmol/L lidocaine in Krebs-Henseleit buffer (10 mmol/L glucose, pH 7.7, at 37°C) or modified St Thomas Hospital solution no. 2, both delivered at 70 mm Hg and 37°C (arrest temperature 22°C to 35°C). RESULTS: Adenosine and lidocaine hearts achieved faster mechanical arrest in (25 ± 2 seconds, n = 23) compared with St Thomas Hospital solution hearts (70 ± 5 seconds, n = 24; ...
Title:Advances in Food Allergy Diagnosis. VOLUME: 14 ISSUE: 3. Author(s):Joana Gomes-Belo, Farah Hannachi, Kate Swan and Alexandra F. Santos*. Affiliation:Childrens Allergy Service, Evelina Childrens Hospital, Guys and St Thomas Hospital, London, Childrens Allergy Service, Evelina Childrens Hospital, Guys and St Thomas Hospital, London, Childrens Allergy Service, Evelina Childrens Hospital, Guys and St Thomas Hospital, London, Childrens Allergy Service, Evelina Childrens Hospital, Guys and St Thomas Hospital, London. Keywords:Food allergy, basophil activation test, component-resolved diagnosis, skin prick test, specific IgE, oral food challenge, diagnosis, IgE-mediated, food allergy.. Abstract:An accurate diagnosis of food allergy is extremely important to guide safe and yet not overly restrictive dietary management. The cornerstone of the diagnosis of food allergy is the clinical history; it allows appropriate selection of the allergens to be tested and interpretation of the ...
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Principal Investigator:MORI Tohru, Project Period (FY):1995 - 1996, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Thoracic surgery
Problem- the heart is not susceptible, you cant wait 4/5 mins then take a heart. Bec certain tissues in the body are much more metabolically active than others and If you wait the period of time without circulation they become unusable. The heart is so metabolically active that if u wait even a short period if time after death the heart no longer functions the cells are damaged and when u take the heart and try to implant into someone else it will not function. The only way to preform as successful heart transplant is to open the chest of the donor while the heart is still beating, then u stop the heart urself with injecting preservative cardioplegic solution which perseveres the function of the cells and rapidly cool the heart in a bath of cardioplegic solution then transport the heart and transplant into the recipient and warm it up again the heart. If u follow Jewish law and take the heart after u have waited, it will not be useful- see the problem in heart transplant.. The cornea isnt a ...
Remote ischemic preconditioning (RIPC) protocol before coronary artery bypass surgery consists of 3 cycles of 5 minutes left upper arm ischemia by inflation of a blood pressure cuff to 200 mmHg and 5 minutes of reperfusion after induction of anesthesia before coronary artery bypass surgery. For myocardial molecular analyses, left ventricular biopsies are taken before induction of cardioplegic cardiac arrest and 5 and 10 Minutes after aortic unclamping during reperfusion of the myocardium ...
Results 53 patients were included in the data analysis, comprising 23 urgent patients and 30 elective patients. Mean age of the cohort was 65.3 (±9.8) years, and the men population accounted for the majority (n=47, 88.7%). In the urgent group, half of the patients received prophylaxic doses of dalteparin once daily (n=12, 52.2%), followed by 4 patients (17.4%) who received the dose for acute coronary syndrome. Antiplatelet therapy was used before CABG surgery in 18 urgent patients (78.3%). Also, all patients were given dalteparin (prophylaxic dose: n=45, 84.9%; treatment dose: n=8, 15.1%) and dual antiplatelets after CABG. There was no symptomatic VTE events within the audit period. Nevertheless, 5 urgent patients (9.4%) suffered from moderate to severe bleeding incidences during surgery, with a significant difference between groups (p=0.012). ...
Following a period in the Department of Anatomy at St Thomas Hospital Medical School he was appointed as Principal Medical Officer to the Sarawak Government. He was subsequently appointed as Professor of Anatomy at St Bartholomews Hospital Medical School, followed by a period as Professor of Anatomy at St Thomas Hospital Medical School and finally, in 1934, he was invited to take over as the Dr. Lees Professor of Anatomy (and effectively the Chair of the Anatomy Department) at the University of Oxford.[2] The following year he was elected a Fellow of the Royal Society.[3] In 1953, Le Gros Clark was one of three men (the others being Joseph Weiner and Kenneth Oakley) who proved that the Piltdown Man was a forgery.[4] He was awarded the Royal Societys Royal Medal in 1961 and delivered their Ferrier Lecture in 1956. He was elected President of the Anatomical Society of Great Britain and Ireland for 1951 to 1953.[5] Papers relating to Le Gros Clark, his grandfather Dr. Frederick Le Gros Clark ...
To visualize the presence and anatomic localization of TNF-alpha within the myocardium, immunohistochemical studies were performed in three groups of isolated hearts: group 1, four hearts undergoing 1 h of cardioplegic ischemia; group 2, four hearts undergoing similar ischemia receiving anti-TNF mAb in the cardioplegic solution (50 mg/ml, total given dose of 1.5 mg; hearts from these two groups were freshly excised immediately after ischemia); and group 3, four isolated hearts excised after 120 min of perfusion (without ischemia) that served as a control group.. Excised hearts were fixed in 10% neutral buffered formalin (Z-fix; Anatech, Ltd.) at room temperature for 18 to 24 h. The tissue was then dehydrated, embedded in paraffin and sectioned (5-μm sections) in a standard manner. Immunohistochemical studies were performed by using a streptavidin-biotin immunoperoxidase method according to the manufacturers instructions (Zymed Lab. Inc.). All reagents were prepared with a dilluent consisting ...
TY - JOUR. T1 - Potassium-induced cardioplegia during normothermic cardiac arrest. Morphologic study of the effect of varying concentrations of potassium on myocardial anoxic injury.. AU - Gharagozloo, F.. AU - Bulkley, B. H.. AU - Hutchins, G. M.. AU - Bixler, T. J.. AU - Schaff, Hartzell V. AU - Flaherty, J. T.. AU - Gardner, T. J.. PY - 1979/4. Y1 - 1979/4. N2 - Most corrective procedures as well as myocardial revascularization require a period of cardiac arrest, and numerous methods have been proposed to protect the myocardium during this ischemic episode. Potassium-induced cardioplegia is one method that appears to be of benefit in this setting. Since it is recognized that myocardial necrosis may result at very high doses of potassium, we examined the effect of varying concentrations of potassium on myocardial anoxic injury. Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various concentrations of K+, ranging from 15 to ...
Conventional CABG uses cardiopulmonary bypass (CPB) and cardiac arrest to provide a stationary heart to facilitate surgery. This technique causes an obligate period of global myocardial ischemia that is attenuated by cardioplegic arrest of the heart. Currently, the optimal method for intraoperative myocardial protection is blood cardioplegia, but this is still associated with low cardiac output syndrome in 10% of cases.12-14 Over the last decade, interest has reemerged in beating heart (off-pump) surgery, which avoids CPB, cardioplegic arrest, and consequently, the global ischemic time. In previous work by our group, it has been shown that in patients with normal left ventricular (LV) function, off-pump CABG is associated with improved early cardiac function compared with conventional CABG with the use of crystalloid cardioplegia.15 Although heart failure patients could potentially benefit from this improvement in early cardiac function, they may not be able to sustain an adequate ...
Two months after hospital discharge, she developed marked exercise intolerance, dyspnea, and orthopnea. The patient was admitted for further investigation. Her pulse rate was 120 beats per minute, blood pressure 90/45 mmHg, and respiratory rate was 35 breaths per minute. A CT scan (Figure 1) and echocardiography (Figure 2) revealed a large tumor mass in the right ventricle extending to the right ventricular outflow tract and the proximal main pulmonary artery. The mass occasionally caused obstruction of the flow of blood through the tricuspid valve into the right ventricle. CT scan of abdomen showed no local recurrence of the liver tumor. The patient was operated upon urgently; a standard procedure was performed with moderate hypothermia, cardiopulmonary bypass, and bicaval cannulation. The heart was arrested with a cold blood cardioplegic solution administered intermittently. At surgery, a right ventriculotomy revealed a large cauliflower-like soft tissue mass of gray-yellow color invading ...
Click the title to purchase the article.. Abstract:. We conducted a prospective randomized trial to compare del Nido (DN) cardioplegia with conventional cold blood cardioplegia (St Thomas [STH]) in pediatric patients. We randomized 100 pediatric patients aged ≤12 years undergoing elective repair of ventricular septal defects and tetralogy of Fallot to the DN and the STH groups. In the DN group, a 20 mL/kg single dose was administered. In the STH group, a 30 mL/kg dose was administered, followed by repeated doses at 25- to 30-minute intervals. The primary outcome was cardiac index that was measured 4 times intra- and postoperatively. Troponin-I, interleukin-6, and tissue necrosis factor-alpha were measured. Myocardial biopsy was obtained to assess electron-microscopic ultrastructural changes. Cardiac indices were significantly higher in the DN group than in the STH group 2 hours after termination of cardiopulmonary bypass (P = 0.0006), after 6 hours (P = 0.0006), and after 24 hours (P ≤ ...
The Medtronic MYOtherm XP Cardioplegia Delivery System- effectively handle air, in a low-prime design, giving fast responses through efficient heat transfer.
Currently established methods of tissue preservation for heart transplantation involve placing the harvested donor heart in a cold, nutrient-rich cardioplegic solution. Clinically, methods like these have only been shown ...
To The Editor:. We read with interest the article by Howell et al.1 We wish to offer some brief comments. Although the concept has been around for nearly 50 years, glucose-insulin-potassium still lacks an established protocol.. Uncertainties surrounding glucose-insulin-potassium are, in part, due to the different contexts, doses, timing, and protocols used.1 The clinical cardiologist may inquire about the rationale for the investigators choice of the specific protocol used in the Hypertrophy, … ...
Dr Peter OKane qualified from Charing Cross and Westminster Medical School in 1995 and commenced specialty training in Cardiology as a research registrar at St Thomas Hospital in 1998. He was subsequently awarded an MD by the University of London for his Thesis on The Role of Nitric Oxide in Coronary Heart Disease. He trained in clinical cardiology on the South Thames NTN scheme working at Worthing Hospital, St Peters Hospital Chertsey, and St Georges Hospital London before completing a 2-year sub-specialization program in Interventional Cardiology at St Thomas supervised by Professor Simon Redwood. He was appointed as a Consultant Interventional Cardiologist at the Royal Bournemouth Hospital in July 2007 ...
Dr Goel graduated in 2004 from Guys, Kings and St Thomas Medical Schools, London. After gaining comprehensive Medical experience working around London and the South East, he entered Gastroenterology and General Medicine specialist training in 2008. He undertook clinical research at Guys & St Thomas Hospitals into the Genetics and Microbiology of Crohns disease and inflammatory bowel disease. During his career, he has been fortunate to undertake clinical attachments in Australia, India, Japan and the Cook Islands. He has published over 30 peer-reviewed articles, authored numerous abstracts, presented at international meetings and written a textbook chapter. He is currently involved in clinical research as a principal investigator for multiple clinical trials involving treatments for inflammatory bowel disease. He was appointed as a full time Consultant in Gastroenterology at Kingston Hospital in 2016, where he took up the role of lead for Endoscopy services. He is currently lead for the ...
August 2000 I am sitting in the Paediatric Intensive Care Unit at Guys Hospital, London. My granddaughter, Holly, was rushed here by ambulance at 2.30 this morning from St Thomas hospital. She has been diagnosed with pneumococcal meningitis. My daughter and I were not allowed to travel with her in the ambulance. We followed in a taxi. The ambulance tore through the deserted London streets, its siren blaring and its lights flashing. Hannah and I are silent. We are beyond speaking.. Hollys eyes are closed. At just fourteen months old, she looks tiny and vulnerable in the big cot. There are tubes everywhere and a nurse is sitting at the end of the cot looking at a screen intently. I dont know what to do. I stroke Hollys head cautiously. She flinches. I stroke her hand with one finger and sing quietly. I know what her favourite songs are. I imagine she is listening to me, but I cant be sure.. I think it was when we were back in St Thomas after leaving the Intensive Care Unit at Guys that ...
An improved method of using a single catheter to infuse blood to the heart, clamping the aorta and delivering a cardioplegia solution. Patient trauma is significantly reduced using a single cannulation. A single catheter (10, 90, 92) is used having a unique balloon (56, 93, 102) for occluding the aorta. In a first embodiment, a single catheter (10) is positioned upwardly in the aorta to infuse oxygenated blood into the ascending aorta via an infusion lumen (72) terminating at the distal end (54), with cardioplegia solution being delivered via openings (82) defined closely adjacent the balloon (56) on the proximal side of the balloon. The inflated balloon (56) isolates the two delivery openings (72,82) from one another to facilitate use of an extracorporeal circuit. In a second embodiment, a single catheter (90) can be positioned downwardly in the aorta to infuse blood via openings (82) into the ascending aorta proximate the subclavian artery, and deliver cardioplegia solution via the distal opening (72)
An improved method of using a single catheter to infuse blood to the heart, clamping the aorta and delivering a cardioplegia solution. Patient trauma is significantly reduced using a single cannulation. A single catheter (10, 90, 92) is used having a unique balloon (56, 93, 102) for occluding the aorta. In a first embodiment, a single catheter (10) is positioned upwardly in the aorta to infuse oxygenated blood into the ascending aorta via an infusion lumen (72) terminating at the distal end (54), with cardioplegia solution being delivered via openings (82) defined closely adjacent the balloon (56) on the proximal side of the balloon. The inflated balloon (56) isolates the two delivery openings (72,82) from one another to facilitate use of an extracorporeal circuit. In a second embodiment, a single catheter (90) can be positioned downwardly in the aorta to infuse blood via openings (82) into the ascending aorta proximate the subclavian artery, and deliver cardioplegia solution via the distal opening (72)
A cardioplegia system in which cardioplegia medication or a mixture of arterial blood and medication is delivered to the heart of a patient undergoing open heart surgery. A cooling system incorporates flat coils vertically disposed in upright tanks in which the level of cooling liquid is controlled and thus the percentage area of the coil which is immersed. This permits the control of the cooling while isolating the blood or medication from the cooling system.
From the Research Department of Epidemiology and Public Health, University College London, United Kingdom (D.O., O.N.); Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (C.P.G.); Department of Cardiology, York Teaching Hospital, United Kingdom (C.P.G.); Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); NIHR Cardiovascular Biomedical Research Unit, Barts Heart Centre, United Kingdom (A.T.); Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (K.A.A.F.); Wessex Cardiac Unit, University Hospital Southampton, United Kingdom (I.A.S.); Kings College London/St Thomas Hospital, United Kingdom (S.R.); University Hospitals of South Manchester, United Kingdom (S.G.R.). ...
From the Research Department of Epidemiology and Public Health, University College London, United Kingdom (D.O., O.N.); Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (C.P.G.); Department of Cardiology, York Teaching Hospital, United Kingdom (C.P.G.); Queen Elizabeth Hospital, Birmingham, United Kingdom (P.L.); The James Cook University Hospital, Middlesbrough, United Kingdom (M.A.d.B.); NIHR Cardiovascular Biomedical Research Unit, Barts Heart Centre, United Kingdom (A.T.); Centre for Cardiovascular Science, University of Edinburgh, United Kingdom (K.A.A.F.); Wessex Cardiac Unit, University Hospital Southampton, United Kingdom (I.A.S.); Kings College London/St Thomas Hospital, United Kingdom (S.R.); University Hospitals of South Manchester, United Kingdom (S.G.R.). ...
EAT your heart out! Michael Marber Department of Cardiology, Cardiovascular Division, The Rayne Institute, St Thomas Hospital, London, UK Correspondence: Professor Michael Marber, Department
2. Cataract extraction and intraocular lens implantation with correction of pre-existing shortsight, longsight and/or astigmatism.. Research interests : Glaucoma. Professional profile : Mr David Broadway trained at St Thomas Hospital, London, Moorfields Eye Hospital, London and The Eye Care Centre, Vancouver, Canada.. His Research (MD) was completed at the Institute of Ophthalmology in London and his Specialist Fellowship at University of British Columbia, Vancouver, Canada. Mr Broadway performs in the order of 750 surgical or laser procedures each year.. His small-incision, no-stitch cataract surgery utilises state-of-the-art technology and is usually performed under topical anaesthetic. Pre-existing refractive errors (long-sightedness, short sightedness and astigmatism) are corrected at the time of cataract surgery and reduce the requirement for glasses following the operation.. The surgical procedures for glaucoma that Mr Broadway offers include trabeculectomy (with or without anti-wound ...
Our sleep patterns are dictated by light and hormones. When light dims in the evening, we produce a chemical called melatonin, which gives the body clock its cue, telling us its time to sleep. The problem is that society has changed, says Professor Paul Gringras, consultant paediatrician and director of the Evelina Paediatric Sleep Disorder Service at Guys and St Thomas Hospital in London.. Artificial light has disrupted our sleep patterns. Bright room lighting, TVs, games consoles, mobiles, tablets and PCs can all emit enough light to stop the natural production of melatonin. These are all distractions, which teens may use well into the night.. That wouldnt be a problem if there was no need to get up early in the morning for school, says Professor Gringras. The early morning wake-ups mean theyre not getting the average eight to nine hours of sleep. The result is a tired and cranky teenager.. Several school districts in the US have introduced later start times for pupils in an ...
Our sleep patterns are dictated by light and hormones. When light dims in the evening, we produce a chemical called melatonin, which gives the body clock its cue, telling us its time to sleep. The problem is that society has changed, says Professor Paul Gringras, consultant paediatrician and director of the Evelina Paediatric Sleep Disorder Service at Guys and St Thomas Hospital in London.. Artificial light has disrupted our sleep patterns. Bright room lighting, TVs, games consoles, mobiles, tablets and PCs can all emit enough light to stop the natural production of melatonin. These are all distractions, which teens may use well into the night.. That wouldnt be a problem if there was no need to get up early in the morning for school, says Professor Gringras. The early morning wake-ups mean theyre not getting the average eight to nine hours of sleep. The result is a tired and cranky teenager.. Several school districts in the US have introduced later start times for pupils in an ...
Professor Monica Spiteri is a consultant respiratory physician and Director of Lung Research at the University Hospitals of North Midlands (UHNM) and Keele University. She completed her medical studies at St Thomas Hospital London and her respiratory specialist training and PhD studies at the Royal Brompton Hospital and Royal Free Hospital, London. She moved to UHNM/Keele University in 1992 to set up an academic infrastructure for both laboratory-based and translational research in interstitial lung disease and chronic airway inflammation, including COPD. Since then she has established an international track record and is a named inventor on respiratory diagnostic patents in the fields of COPD and Pulmonary Fibrosis. Her current research focus is on development of patient-driven point-of-care diagnostics to improve self-management and remote monitoring in respiratory disease, supported by the National Institute Health Research Invention for Innovation programme Her achievement awards have ...
The School of Computing and Communications at Lancaster University has research expertise in communications and networking, computer systems, intelligent systems, software engineering, and human-computer interaction.. A collaborative team, including Dr Mark Rouncefield from the School of Computing and Communications, Guys and St Thomas Hospital, Microsoft Research, and Kings College London, piloted the touchless interaction component using Kinect for Windows hardware and the Kinect for Windows Software Development Kit (SDK). This gesture-based system allowed the vascular surgery team to maintain a sterile environment, whilst being able to view and manipulate medical images through a combination of gesture and voice control. It has also been extended to applications within neurosurgery.. The computer program visualises on-screen the patients 3D anatomy, which is acquired from a group of 2D images (which look like x-rays) taken at different view directions. The Kinect technology allows the ...
BORIS JOHNSONS brush with death could hardly have been closer. In his interview today he reveals doctors were already planning a dreadful announcement if things went wrong.. At one point he was so ill he was nearly put on a ventilator with a tube down my windpipe.. It was a tough old moment, he admits. I wont deny it.. With black humour, he says he was aware the doctors had a strategy for a death of Stalin type scenario.. But what also comes through this emotionally raw interview is Boriss incredible fighting spirit.. His ordeal in intensive care at St Thomas hospital was undoubtedly one of the nations darkest hours during this dreadful crisis.. But his remarkable recovery in a few short weeks and the birth of his baby son Wilfred inspire new life and hope.. Who better to revive the country than someone who has himself bounced back from the brink?. Boriss optimism will now be needed as never before, and his return to Downing Street has already filled the leadership vacuum.. He will ...
p]Thanks for coming to my fundraising page. [/p][p]My cousin, John Mathews, had recently retired from a long and distinguished career as a rheumatologist at St Thomas Hospital in London and went on a trip around South East Asia with his wife, Wendy. When he returned he didnt feel quite right and had some unusual symptoms. He rapidly deteriorated and almost two years ago to the day of the Marathon, John died of pneumococcal meningitis.[/p][p]Although initially having a place in last years race, alongside his daughter Cathy and son Colin, I had to defer my entry due to injury. This year Im fighting fit and training is going very well, despite a lot of on-calls, weekends at work and two young and tiring children![/p][p]Meningitis is still a devastating disease. Im currenlty working in infectious diseases and meningitis is seen in every hospital around the country - survival rates are improving but it still regularly kills or leaves survivors disfigured. Just a few weeks ago a 19 year old ...
Few people are aware that there is a clear link between obesity and cirrhosis. Photograph: Dominic Lipinski/PA. Doctor Jude Oben had grim news for a patient last week. The liver expert told the 60-year-old man that he had cirrhosis - for the second time in his life.. Only four years ago Obens patient had required a liver transplant after his first bout of cirrhosis, a condition he had contracted because he was obese. Unfortunately my patient continued to overeat and remained obese, said Oben, a hepatologist based at the Royal Free and St Thomas hospitals in London. As a result, he contracted cirrhosis again. Sadly, I had to tell him that this time it was very unlikely he would be given another liver.. Obens patient is one of a tidal wave of cases of cirrhosis, triggered by obesity, that threatens to sweep through hospitals across the UK. People might be aware that there are metabolic disorders such as diabetes and high blood pressure associated with obesity, but very few know about the ...
If you are referred to us for Malaria testing and it is outside our normal opening hours, please go directly to the Accident and Emergency Department at St Thomas Hospital or Kings College Hospital. If you are taking medication with food and need to fast before your blood test, please ask your doctor for advice ...
Greg Martin1 , Frank M Brunkhorst2 , Jonathan M Janes3 , Konrad Reinhart2 , David P Sundin3 , Kassandra Garnett4 and Richard Beale5 1Division of Pulmonary, Allergy, and Critical Care, Emory University, 615 Michael Street, Atlanta, Georgia, 30322, USA. 2Department of Anesthesiology and Intensive Care, Friedrich Schiller University, Erlanger Allee 101, Jena, 07743, Germany. 3Lilly Research Laboratories, Eli Lilly and Co., Lilly Corporate Center, Indianapolis, Indiana, 46285, USA. 4 StatProbe, 1001 Winstead Drive, Cary, North Carolina, 27513, USA. 5Intensive Care Unit, Guys and St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK. ...
Whether it was Voltaire, Winston Churchill or someone else who said it, the words with great power comes great responsibility have never been truer. There are many benefits of genetic testing and personalised medicine for people whove already been diagnosed with a disease. However, there are still serious questions to consider when it comes to using genetic testing for diagnosis, screening and prevention. We spoke to Sarah Rose, a genetic counsellor at Guys and St Thomas Hospital to ask about some of the issues she deals with on a daily basis. She said: Genetic testing is available for men with, or at risk of, prostate cancer on the NHS, but only for men with a very strong family history of prostate, breast and/or ovarian cancer.. These are the cancers most strongly linked to BRCA1 or BRCA2 mutations, which are the only known prostate cancer genes we can test for inherited mutations at the moment. This is because we can only offer testing when we know what the associated risk of a ...
Dr Harriet Deere became a consultant histopathologist in 2001. She is based at the cellular immunology department at St Thomas Hospital.
Talks are held on selected Fridays at 1500h in the Seminar Room of the Centre for the Developing Brain at St Thomas Hospital ...
TY - JOUR. T1 - Glutamine provides cardioprotection during reperfusion (but not during cardioplegia) after prolonged cardioplegic arrest with St Thomass Solution in the isolated working rat heart. AU - Khogali, SEO. AU - Lyall, JA. AU - Rennie, M. J.. PY - 1998/9. Y1 - 1998/9. U2 - 10.1111/j.1469-7793.1998.tb00070.x. DO - 10.1111/j.1469-7793.1998.tb00070.x. M3 - Meeting abstract. VL - 511. SP - 74P-74P. JO - Journal of Physiology. JF - Journal of Physiology. SN - 0022-3751. IS - Suppl.. ER - ...
(KudoZ) Italian to English translation of Infusione di soluzione cardioplegica ST. Thomas II direttamente nel bulbo aorti: St Thomas cardioplegic soution is / was infused directly into the aortic root [cardiology - Medical: Cardiology (Medical)].
CREATE-ECLA-GIK: The Clinical Trial of Reviparin and Metabolic Modulation in Acute Myocardial Infarction Treatment Evaluation - Estudios Cardiol gicos Latinoam rica - Glucose-Insulin-Potassium. -No Improvement in 30-day Mortality with High-dose Glucose-Insulin-Potassium (GIK) Infusion by Dr. S.R. Mehta (AHA 2004) GIPS II: Glucose-Insulin-Potassium Study-2. -In Patients with ST Elevation Myocardial Infarction Without Signs of Heart Failure by Dr. Jorik Timmer (ACC 2005) IMMEDIATE: Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency Care: A Double-Blind Randomized Controlled Trial of Intravenous Glucose, Insulin, and Potassium (GIK) for Acute Coronary Syndromes in Emergency Medical Services. - Trial Results by Dr. Harry P. Selker (ACC 2012) (Return to Contents) ...
DNA-themed products are becoming increasingly common within the consumer marketplace. Companies claim to be able to design cosmetic packages, fitness programmes and dietary regimes based on the genetic make-up of each individual client. However, genetic literacy within the general population is typically poor, which may make it difficult for potential customers to scrutinise these products with a discerning eye.. Dr Melita Irving, a consultant in clinical genetics at Guys and St. Thomas Hospital, has created The Human DNA Manual - Understanding Your Genetic Code, a comprehensive reference book, which has the potential to improve genetic literacy by examining the many ways in which the study of DNA impacts our modern-day lives.. The Human DNA Manual starts by introducing the reader to the fundamental science that underpins the field of genetics, including, the basic structure of DNA and how the genetic code translates into physical characteristics. The information is broken down into short, ...
The first NHS TomoTherapy treatment machine in London is up and running less than two months after being installed, treating over 30 people a day at Guys...
The first heart transplant (OHT) was performed in 1967 at Groote Shuur Hospital in Cape Town, South Africa by Dr. Christiaan Barnard. It remains the only definitive thera..
The second phase of the nursing procedure is diagnosing. In light of this, it is thought that, in oncology hospital solutions, the nursing process with emphasis on the diagnosis phase is important to the oncology hospital services because of a high frequency of physical and mental difficulties that compromise the standard of life of patients undergoing cancer therapy. 1 form of theory may not be applied every patient stipulation.. Whats more, a valuable part of superior patient care is dependent on preventative measures. In the event the outcomes are high, then you ought to seek out guidance about the correct treatment to fix the high ketone level and the protocol for re-testing for ketones until the outcome is negative. Its also hard to treat and might wind up in local water supply.. The very first step of the nursing procedure is called assessment. To assist you in getting started, here are a few of the important nursing care plans for hypertension you will need to prepare. Perhaps you might ...
Professor Tim Spector, of St Thomas, said there was evidence that people who snore produce more of a hormone called ghrelin which can increase the appetite and may make them overweight. He believes that one reason why the genes, which disrupt sleep, may have persisted through the ages is because they ...
Professor Tim Spector, of St Thomas, said there was evidence that people who snore produce more of a hormone called ghrelin which can increase the appetite and may make them overweight. He believes that one reason why the genes, which disrupt sleep, may have persisted through the ages is because they ...
Posts about http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0142(19990915)86:61064::AID-CNCR243.0.CO;2-1/full written by didymusjudasthomas
TY - JOUR. T1 - Retrograde continuous warm blood cardioplegia. T2 - A new concept in myocardial protection. AU - Salerno, Tomas A.. AU - Houck, James P.. AU - Barrozo, Carlos A.M.. AU - Panos, Anthony. AU - Christakis, George T.. AU - Abel, James G.. AU - Lichtenstein, Samuel V.. PY - 1991/2. Y1 - 1991/2. N2 - This report presents the results in our first clinical series of patients receiving continuous warm blood cardioplegia through the coronary sinus. Warm oxygenated blood cardioplegia has certain theoretical advantages, such as continuously supplying oxygen and substrates to the arrested heart while avoiding the side effects of hypothermia. Retrograde infusion of cardioplegia also offers certain advantages (eg, in valve operations and in patients with severe coronary artery disease) that are complementary to warm blood cardioplegia. Retrograde warm blood cardioplegia was used in 113 consecutive patients (85 men and 28 women with a mean age of 61 years) undergoing various procedures. Three ...
after surgeries that used a NECC drug. The drug, called cardioplegic solution, is administered to paralyze the heart during surgery. It is not clear whether the fungal infections seen in these two patients were caused by the cardioplegic solution, or by something else, the FDA noted ...
Published in The Journal of the American Society of Anesthesiologists in 1 2015.. Authors: Jochen D. Muehlschlegel, M.D. et al Danos C. Christodoulou, Ph.D.. Background: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of human left ventricular myocardium at baseline and after exposure to cold cardioplegia-induced ischemia as a human ischemia model.. Methods: The authors obtained biopsies from 45 patients undergoing aortic valve replacement surgery at baseline and after an average of 79 min of cold cardioplegic arrest. Samples were RNA sequenced and analyzed with the Partek® Genomics Suite (Partek Inc., St. Louis, MO) for differential expression. Ingenuity Pathway Analysis (Ingenuity Systems, Redwood City, CA) and Biobase ExPlain (Biobase GmbH, Wolfenbuettel, Germany) systems were used for functional and pathway ...
Background:: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of human left ventricular myocardium at baseline and after exposure to cold cardioplegia-induced ischemia as a human ischemia model. Methods:: The authors obtained biopsies from 45 patients undergoing aortic valve replacement surgery at baseline and after an average of 79 min of cold cardioplegic arrest. Samples were RNA sequenced and analyzed with the Partek® Genomics Suite (Partek Inc., St. Louis, MO) for differential expression. Ingenuity Pathway Analysis (Ingenuity Systems, Redwood City, CA) and Biobase ExPlain (Biobase GmbH, Wolfenbuettel, Germany) systems were used for functional and pathway analyses. Results:: Of the 4,098 genes with a mean expression value greater than 5, 90% were down-regulated and 9.1% were up-regulated. Of those, 1,241 were significantly ...
Minimally invasive surgery is associated with a faster postoperative recovery because of reduced postoperative pain and improved respiratory function, especially in elderly patients. We began using a minimally invasive approach ismall parasternal incision jfor isolated aortic valve replacement iMICS AVR jfrom January 2011. Between January 2011 and February 2012, 32 patients underwent MICS AVR surgery. The mean age was 73 years irange 57-85 years j;69% were women. MICS AVR was performed through a skin incision of 6.5 }0.5cm along the third intercostal space. Cardiopulmonary bypass was established through the right femoral artery and vein. The patients were cooled to 28 , the aorta was crossclamped with a flex clamp, and antegrade cardioplegic solution was given into the aortic root or selectively into the coronary ostia. The aortic valve procedure was performed in a standard fashion. If the distance to the aortic valve was too far, we used surgical instruments for minimally invasive surgery. ...
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TY - JOUR. T1 - Simultaneous Antegrade and Retrograde Reperfusion After Cardioplegic Arrest for Coronary Artery Bypass. AU - Carpenter, Andrea J. AU - Follette, David M.. AU - Sheppard, Barry. AU - Yoshikawa, Richard. AU - Sam, James. PY - 1985. Y1 - 1985. N2 - Abstract Retrograde coronary sinus reperfusion with warm blood during proximal anastomoses permits completion of myocardial revascularization under a single cross‐clamp application. Reperfusion with both antegrade (via arterial and vein grafts) and retrograde (via coronary sinus catheter) warm blood has raised concerns about maldistribution of perfusate or overpressurization of capillary beds. This prospective, randomized design compares post‐cardioplegic myocardial recovery among patients receiving retrograde reperfusion only and patients receiving simultaneous antegradelretrograde reperfusion. Twenty‐four patients were selected among all presenting as outpatients for elective coronary artery bypass (CAB). Each patient underwent ...
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Division of Imaging Sciences & Biomedical Engineering, Medical Engineering Centre, Kings College London, 3rd Floor, Lambeth Wing, St Thomas Hospital, SE1 7EH London, UK ...
Mo was placed in intensive care. A doctor said he was going to put me to sleep for a few hours to insert a tube to help me breathe, he says.. The next thing Mo remembers is waking up nine days later in St Thomas Hospital, in central London, hooked up to life-support equipment. It was a complete shock, he says. I had tubes and needles going in and out of me. I couldnt speak because there was a large tube in my mouth.. The drama of the previous nine days - his familys distress, the chaplains prayers, moving hospital - were revealed to him over the following days.. When I woke up, the medical staff, family and friends helped me piece together the past nine days.. It was very upsetting to be told that I had come close to dying.. The malaria parasite had been attacking my lungs and they were filling up with fluid.. Pint after pint of brown fluid was being pumped out. The doctors feared I was going to drown in this fluid.. In falciparum malaria, fluid can accumulate in the lungs and ...
Mo was placed in intensive care. A doctor said he was going to put me to sleep for a few hours to insert a tube to help me breathe, he says.. The next thing Mo remembers is waking up nine days later in St Thomas Hospital, in central London, hooked up to life-support equipment. It was a complete shock, he says. I had tubes and needles going in and out of me. I couldnt speak because there was a large tube in my mouth.. The drama of the previous nine days - his familys distress, the chaplains prayers, moving hospital - were revealed to him over the following days.. When I woke up, the medical staff, family and friends helped me piece together the past nine days.. It was very upsetting to be told that I had come close to dying.. The malaria parasite had been attacking my lungs and they were filling up with fluid.. Pint after pint of brown fluid was being pumped out. The doctors feared I was going to drown in this fluid.. In falciparum malaria, fluid can accumulate in the lungs and ...
Mo was placed in intensive care. A doctor said he was going to put me to sleep for a few hours to insert a tube to help me breathe, he says.. The next thing Mo remembers is waking up nine days later in St Thomas Hospital, in central London, hooked up to life-support equipment. It was a complete shock, he says. I had tubes and needles going in and out of me. I couldnt speak because there was a large tube in my mouth.. The drama of the previous nine days - his familys distress, the chaplains prayers, moving hospital - were revealed to him over the following days.. When I woke up, the medical staff, family and friends helped me piece together the past nine days.. It was very upsetting to be told that I had come close to dying.. The malaria parasite had been attacking my lungs and they were filling up with fluid.. Pint after pint of brown fluid was being pumped out. The doctors feared I was going to drown in this fluid.. In falciparum malaria, fluid can accumulate in the lungs and ...
There was no significant difference in the rate of progression to MI among patients who received GIK (n = 200; 48.7%) versus those who received placebo (n = 242; 52.6%) (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.66-1.13; p = 0.28). Thirty-day mortality was 4.4% with GIK versus 6.1% with placebo (hazard ratio [HR], 0.72; 95% CI, 0.40-1.29; p = 0.27). The composite of cardiac arrest or in-hospital mortality occurred in 4.4% with GIK versus 8.7% with placebo (OR, 0.48; 95% CI, 0.27-0.85; p = 0.01). Among patients with ST-segment elevation (163 with GIK and 194 with placebo), progression to MI was 85.3% with GIK versus 88.7% with placebo (OR, 0.74; 95% CI, 0.40-1.38; p = 0.34); 30-day mortality was 4.9% with GIK versus 7.7% with placebo (HR, 0.63; 95% CI, 0.27-1.49; p = 0.29). The composite outcome of cardiac arrest or in-hospital mortality was 6.1% with GIK versus 14.4% with placebo (OR, 0.39; 95% CI, 0.18-0.82; p = 0.01). Serious adverse events occurred in 6.8% (n = 28) with GIK ...
Cardioplegia is intentional and temporary cessation of cardiac activity, primarily for cardiac surgery. The word cardioplegia combines the Greek cardio meaning the heart, and plegia paralysis. Technically, this means arresting or stopping the heart so that surgical procedures can be done in a still and bloodless field. Most commonly, however, the word cardioplegia refers to the solution used to bring about asystole of the heart, or heart paralysis. One of the first physicians to use the term cardioplegia was Dr. Lam in 1957. However his work on the myocardial protection was preceded serendipitously by Sidney Ringer in the late 1800s. At that time Ringer and colleagues noticed that tap water had the ability to increase contractility of the heart, likely due its high calcium content. Sidney ringer also commented on the importance of potassium ion concentration on depressing intrinsic heart rhythmn. Through a series of experiments performed on frog and canine hearts, reversible arrest was ...
BACKGROUNDDiabetes mellitus is an independent risk factor for early postoperative mortality and complications after coronary artery bypass grafting (CABG). We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes.METHODS AND RESULTSTwenty atrial myocardium samples were harvested from 5 type II insulin-dependent diabetic and 5 matched nondiabetic patients undergoing CABG, before and after CPB/C. Oligonucleotide microarray analyses of 12625 genes were performed on the 10 sample pairs using matched pre-CPB tissues as controls. Array results were validated with Northern blotting and immunoblotting. Compared with pre-CPB/C, post-CPB/C myocardial tissues revealed 851 upregulated and 480 downregulated genes with a threshold P, or =0.025 (signal-to-noise ratio, 4.04) in the diabetic group, compared with 480 upregulated and 626 downregulated genes (signal-to-noise ratio, 3.04) in the nondiabetic group ...
Ischaemic heart disease is a leading cause of mortality in the western world. A number of patients undergo coronary artery bypass graft (CABG) surgery as treatment for ischaemic heart disease. With the rise of interventional procedures, patients who are coming to have CABG surgery are higher risk1. Remote ischaemic preconditioning (RIPC) has been shown to reduce perioperative myocardial injury (PMI) in patients having CABG even when cold blood cardioplegia or intermittent cross clamp fibrillation is used as cardioprotective measures. These patients have a general anaesthetic with multiple infusions including Glyceryl Trinitrate (GTN). The use of GTN in these patients is based on theoretical assumptions of coronary vasodilation pre operatively along with maintaining graft potency postoperatively. We intend to investigate the effect of GTN in patients undergoing cardiac surgery being subjected to RIPC in its role as a Nitric Oxide (NO) donor. Exogenous NO has been shown to be cardioprotective in ...
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Szabo Z, Arnqvist H, Hakanson E, Jorfeldt L, Svedjeholm R: Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with type II diabetes. Clin Sci 101:37-43, 2001. Findings. Szabo et al. investigated the use of a glucose-insulin-potassium infusion (GIK) on myocardial substrate utilization after coronary surgery in 20 patients with type 2 diabetes. Patients were randomly allocated to either postoperative high-dose GIK or standard postoperative care, including insulin infusion, if necessary, to keep blood glucose ,10 mmol/l. Myocardial substrate utilization and hemodynamic status were studied using coronary sinus catheters and Swan-Ganz catheters, respectively. Infusion of GIK caused a shift toward carbohydrate utilization, with significant lactate uptake throughout the study period and significant uptake of glucose after 4 h. Arterial levels of nonesterified fatty acids and β-hydroxybutyric acid decreased, and after 1 h no significant uptake of ...
Though the plot of the novel is rather sad and scary, I have read many true-crime novels where the serial killer kills about fifteen women before cutting them up and burying them. The details in some of those novels are truly disgusting yet this is the book that frightens me most of all. Four murders. Seems like a small amount compared to fifty but losses of life nonetheless. So chilling and personal is Capotes In Cold Blood that I was a bit nervous about keeping the book by my bed. Capote pulls us right into the lives of the Clutter family: from Nancys social personality to Kenyons quiet yet intelligent attitude. We get glimpses of their rooms and their habits. We stay with them for a few days, observing through Capotes trained eye of their lifestyles and routines. We become so fully immersed in the details of their lives that when they are ripped from us, we feel the terrifying loss. One line in particular jolted me and that was right after Nancy Clutter has been discovered dead and Mr. ...
Robert Blake is taken into custody by detective John Forsythe, right, and another law officer in a scene from the 1967 film In Cold Blood. See full story
‎Sleuths will have to figure out who done it, but the real crime is the backdrop here: the endless heating of a fragile planet.-BILL MCKIBBEN, author of Falter A thrilling contribution to the new wave of cli-fi hitting the shelves, Cold Blood, Hot Sea pits cli…
Download this Cold Blood Criminal photo now. And search more of the webs best library of royalty-free stock images from iStock.
Overview of In Cold Blood, 1967, directed by Richard Brooks, with Robert Blake, Scott Wilson, John Forsythe, at Turner Classic Movies
At the assisted conception unit (ACU) we offer a comprehensive service, from initial investigations through to specialised procedures.
There are 160 calories in 1 loaf (2 oz) of Thomas Sahara White Pita Pocket. Youd need to walk 42 minutes to burn 160 calories. Visit CalorieKing to see calorie count and nutrient data for all portion sizes.
The terms of Robert Thomas deal with the Rams were announced yesterday. The first-round pick from UCLA will get $5.75 million over five years and he got a $3 million signing bonus. Steve Bellisari is the Rams only unsigned draftee, but the sixth-round pick says his agent and the team are close to a deal….The Chiefs will be talking with Ryan Sims again today. Sims, who was taken in the first round out of North Carolina, is still unsigned. Hes already moved into the starting spot as a defensive tackle on Dick Vermiels depth chart.. ...
Thomas Sahara Wheat Pita Bread found at Hannaford Supermarket. Add to online shopping list or grocery cart for Hannaford To Go.
What originally looked like a heart attack turns out to be a calculated execution. Soon, detectives unravel a murder plot that hits a little too close to home.
Who is this Rory chap everyone is on about, I went back and re-watched all the episodes of this season, no Rory, surely someone is pulling someones leg.
I have had this book languishing on my shelves for too long without being read, so it is traveling to another bookcrosser as a RABCK to be enjoyed by them ...
With David Attenborough. A nature documentary series written and presented by David Attenborough, that looks at the evolution and habits of amphibians and reptiles.
Author Bio:. Kelly qualified from Guys, Kings and St Thomas in 2003. She is currently working as an associate at Regency Dental, Swanage and has been a member of the IAS Academy since completing here initial training in 2015.. The Case. A 48-year-old female patient was referred to me by a colleague in-house. She was unhappy with the appearance of her rotated upper centrals and misaligned lower incisors as they were difficult to clean and kept getting stained. She had been considering veneers when she saw information on the IAS Inman Aligner in the waiting room.. With very little dental history, no restorations and a regular attender to the dentist and hygienist, the patient was medically fit and well. A thorough orthodontic assessment revealed a Class I occlusion on a Class I skeletal base. There was mild crowding in the upper and lower labial segments, the upper centrals were rotated and the upper canines buccally placed with space distal to these. Periapical radiographs taken of the ...
Non-Europeans have a higher frequency of the gene variants that increase the risk of lupus as compared to the European population, a new study from researchers at the National Institute for Health Research Biomedical Research Centre at Guys and St Thomas and Kings College London, has confirmed.
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... pharmaceutical solutions MeSH D27.720.280.775.322 - cardioplegic solutions MeSH D27.720.280.775.483 - dialysis solutions MeSH ... cardioplegic solutions MeSH D27.505.954.411.222 - cardiotonic agents MeSH D27.505.954.411.320 - fibrinolytic agents MeSH ... ophthalmic solutions MeSH D27.720.280.775.822 - sclerosing solutions MeSH D27.720.280.779 - powders MeSH D27.720.280.785 - ... contact lens solutions MeSH D27.505.954.122.425.300 - dental disinfectants MeSH D27.505.954.158 - anti-inflammatory agents MeSH ...
... pharmaceutical solutions MeSH D26.776.708.160 - cardioplegic solutions MeSH D26.776.708.322 - dialysis solutions MeSH D26.776. ... contact lens solutions MeSH D26.776.314 - hypertonic solutions MeSH D26.776.314.420 - glucose solution, hypertonic MeSH D26.776 ... saline solution, hypertonic MeSH D26.776.399 - hypotonic solutions MeSH D26.776.498 - isotonic solutions MeSH D26.776.675 - ... ophthalmic solutions MeSH D26.776.708.822 - sclerosing solutions MeSH D26.776.741 - rehydration solutions MeSH D26.878.250 - ...
3. However, the perfusion of the low Ca cardioplegic solution in which the Mg concentration was high increased intracellular Ca ... A study on the optimal ions compostion in hyperkalemic cardioplegic solution in each growth stage. Research Project ... The effects of calsium (Ca) and magnesium (Mg) ions in cardioplegic solutions on intracellular calcium ion handling and ... The findings suggest that in immature myocardium, the concentrations of Ca and Mg present in cardioplegic solutions influence ...
Thomas II direttamente nel bulbo aorti: St Thomas cardioplegic soution is / was infused directly into the aortic root [ ... Infusion of St Thomas Cardioplegic solution directly into the aortic root. Explanation:. I think the word order makes a ... Infusion of St Thomas Cardioplegic solution directly into the aortic root. Monica Alves. ... St Thomas cardioplegic soution is / was infused directly into the aortic root. xxxElena Sgarbo. ...
... with cardioplegia solution being delivered via openings (82) defined closely adjacent the balloon (56) on the proximal side of ... and deliver cardioplegia solution via the distal opening (72) downward toward the aortic base. The balloon (102) is preferably ... clamping the aorta and delivering a cardioplegia solution. Patient trauma is significantly reduced using a single cannulation. ... Cardioplegic solution. US5011469 *. 29. Aug. 1988. 30. Apr. 1991. Shiley, Inc.. Peripheral cardiopulmonary bypass and coronary ...
Activated protein C in the cardioplegic solution on a porcine model of coronary ischemia-reperfusion has deleterious ...
... after prolonged cardioplegic arrest with St Thomass Solution in the isolated working rat heart. Journal of Physiology, 511( ... after prolonged cardioplegic arrest with St Thomass Solution in the isolated working rat heart, Journal of Physiology, vol. ... after prolonged cardioplegic arrest with St Thomass Solution in the isolated working rat heart. In: Journal of Physiology. ... after prolonged cardioplegic arrest with St Thomass Solution in the isolated working rat heart. / Khogali, SEO; Lyall, JA; ...
Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various ... Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various ... Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various ... Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various ...
... heart protected and arrested during cardiopulmonary bypass by maintaining a desired ratio of blood and cardioplegic solution at ... Discover the Medtronic Perfusion Solutions Difference. Partnering with Medtronic goes beyond a history of perfusion excellence. ...
... nutrient-rich cardioplegic solution. Clinically, methods like these have only been shown ... ...
... cardioplegic solution which perseveres the function of the cells and rapidly cool the heart in a bath of cardioplegic solution ...
After 2 and 4 hours of arrest (cardioplegic solution delivered every 20 minutes for 2 minutes at 37°C), only 50% (4 of 8) and ... Coronary vascular resistance during delivery of cardioplegic solution was significantly lower (P , .05) after 2 and 4 hours in ... We tested a new polarizing normokalemic cardioplegic solution employing adenosine and lidocaine as the arresting, protecting, ... CONCLUSIONS: We conclude that adenosine and lidocaine polarizing cardioplegic solution confers superior cardiac protection ...
The closed coil system prevents any contact of the ice water with the cardioplegic solution and the coil unit with the ... This coil is used to pass the solution of blood and/or drugs through a cooling medium, usually ice water, to cool the solution ... blood of the patient has also been developed and the use of blood as the vehicle for delivery of the cardioplegic solution has ... This will cause a change in the solution level in the bubble trap although the trap will continue to function as intended. A ...
The amount of particulate matter present in Bretschneiders cardioplegic solution (HTK) was assessed by laser-mediated particle ... Impact of particulate contamination in crystalloid cardioplegic solutions: studies by scanning and transmission electron ... Filtration of the HTK solution by a terminal inline filter (0.2 micron) significantly reduced the number of particles. In order ...
The myocardial protection provided by cardioplegic solution using buffered, isosmotic potassium (30 mEq. per liter) was ... The cardioplegic solution (Group CS) or cold blood (Group CB) was infused every 15 minutes through a cooling coil to reduce the ... Cardioplegic solution thus appears to be superior to the intermittent perfusion of cold blood for myocardial protection. The ... The myocardial protection provided by cardioplegic solution using buffered, isosmotic potassium (30 mEq. per liter) was ...
Whether crystalloid cardioplegic delivery systems, in fact., deliver tbe solution to the heart at a temperature of less than 6ï ... Cardiac hypothermia is induced and maintained primarily by infusing cold cardioplegic solutions Inlo the beart. ... Whether crystalloid cardioplegic delivery systems, in fact., deliver tbe solution to the heart at a temperature of less than 6ï ... oa Cardiovascular Journal of Africa - Practicalities of delivering crystalloid cardioplegic solutions: Part II. Temperature * ...
Cardioplegic solution is used to induce cardiac muscle paralysis during open heart surgery to prevent injury to the heart." ... Cardioplegic solution is a chemical mixture that is used to disrupt the normal electrical activity of the heart (essentially, ... FDA Warning for NECC Cardioplegic Solutions. October 17, 2012 - The New England Compounding Center (NECC) has recalled more ... The man was treated with cardioplegic solution during open heart surgery, and the FDA is concerned that other people may have ...
Here we report the effects of hypothermic storage in EuroCollins solution, St Thomas Hospital cardioplegic solution and a ... Here we report the effects of hypothermic storage in EuroCollins solution, St Thomas Hospital cardioplegic solution and a ... Having established a suitable period for study, storage in EuroCollins, St Thomas Hospital cardioplegic solution or ... EuroCollins solution (0.013±0.002) or St Thomas Hospital solution (0.025±0.005) compared to unstored lungs (0.068±0.007). ...
Thomas Hospital cardioplegic solution, for stopping the heart. In the other 92 patients, plegisol cardioplegic solution was ... 52.2%, p = 0.026). This study shows that the modified St.Thomas Hospital cardioplegic solution is preferred for avoiding ... St.Thomas Hospital cardioplegic solution was used in group S and plegisol solution in group P. Every 100 ml of solution was ... Thomas Hospital cardioplegic solution, for stopping the heart. In the other 92 patients, plegisol cardioplegic solution was ...
Cardioplexol® (Swiss Cardio Technologies) is a hyperkalemic, low-dose, single-shot cardioplegic solution which offers immediate ...
Development of cardioplegic solution without potassium: experimental study in rat Development of cardioplegic solution without ... solutions (P. solutions showed no cytotoxicity effect after 24 hours of cells exposure to cardioplegic solutions. CONCLUSION:. ... All cardioplegic solutions are based on potassium for induction of cardioplegic arrest. OBJECTIVE:. To assess a cardioplegic ... Full text: Available Index: LILACS (Americas) Main subject: Organ Preservation / Cardioplegic Solutions / Heart / Heart Arrest ...
Myocardial protection during minimally invasive mitral valve surgery: strategies and cardioplegic solutions.. ...
... infusion of cardioplegic solution every 30 minutes for 1 minute; Group 3, infusion of cardioplegic solution every 20 minutes ... infusion of cardioplegic solution every 30 minutes for 1 minute; Group 3, infusion of cardioplegic solution every 20 minutes ... infusion of cardioplegic solution every 30 minutes for 1 minute; Group 3, infusion of cardioplegic solution every 20 minutes ... infusion of cardioplegic solution every 30 minutes for 1 minute; Group 3, infusion of cardioplegic solution every 20 minutes ...
Cardioplegic solution. US4994444 *. 31 Jul 1987. 19 Feb 1991. The Trustees Of Columbia In The City Of New York. Macromolecules ... Ringers solution, lactated Ringers solution, Locke-Ringers solution, Krebs-Ringers solution, Hartmanns balanced saline, ... 129-134 (1989). The final DCLHb solution had a concentration of 10.2 g/dl (see Table 2). The DCLHb solution was stored at -70 C ... The resulting solution is isosmotic with whole blood, hyperoncotic (approximately 40 torr), and has the composition shown in ...
The modified Krebs-Henseleit buffer-based cardioplegic solution (mKHB) and St. Thomas Hospital solution No. 2 (STH2) were ... cardioplegic solution might provide better myocardial protection than well-known crystalloid cardioplegic solutions because of ... During global ischemia, the temperatures of the heart and the cardioplegic solutions were maintained at either 37°C (60 min of ... The data suggest that the Krebs-Henseleit buffer-based cardioplegic might be superior to the standard crystalloid solution ( ...
5.4 Cardioplegic Solutions In another aspect, the invention provides cardioplegic solutions comprising adenosine and inosine at ... In some embodiments, the cardioplegic solution contains no additional cardioplegic actives, such as potassium. In other ... In various embodiments, the cardioplegic solutions comprise adenosine and inosine in an A:I ratio of at least about 1:1, 1:2, 1 ... In certain embodiments, the cardioplegic solution contains 0.5 to 3 mg/ml of adenosine and 0.5 to 15 mg/ml of inosine. ...
This solution was used as the cardioplegic solution containing procaine hydrochloride and the other solution was prepared with ... Tabriz, Iran) and 2, the group of cardioplegic solution with lidocaine additive. The cardioplegic solution was prepared ... different cardioplegic solutions play a key role. Differences in the types and contents of cardioplegic solutions may lead to ... and choosing a cardioplegic solution is important in this regard (3, 8). The cardioplegic solution protects the myocardium ...
Gender-dependent Metabolic Remodeling During Heart Preservation in Cardioplegic Celsior and Histidine Buffer Solution: Erratum ... Gender-dependent Metabolic Remodeling During Heart Preservation in Cardioplegic Celsior and Histidine Buffer Solution. J ... Gender-dependent Metabolic Remodeling During Heart Preservation in Cardioplegic Celsior and Histidine Buffer Solution: Erratum ...
Cardioplegic Solution for Cardiac Perfusion - Current. *Chloroquine Tablets - Current. *Dexpanthenol Injection - Current ...
CARDIOPLEGIC SOLUTION. Atropine sulfate [Alcon Laboratories, Inc.]. ATROPINE SULFATE OPHTHALMIC SOLUTION 1%STERI-UNITS®STERILE ...
Potassium is the most common component in cardioplegic solutions. High extracellular potassium levels reduce the membrane ... In one preferred embodiment, saline solution is used. Alternatively, other energy-conducting liquids, such as Ringers solution ... Ringers solution and/or sugar solutions such as dextrose in water or saline. Other possible carriers that may be used include ... Carrier solutions may or may not be buffered.. Drug formulations or compositions may include antioxidants or preservatives such ...
Potassium is the most common component in cardioplegic solutions. High extracellular potassium levels reduce the membrane ... Ringers solution and/or sugar solutions such as dextrose in water or saline. Other possible carriers that may be used include ... Ringers solution and/or sugar solutions such as dextrose in water or saline. Other possible carriers that may be used include ... Ringers solution and/or sugar solutions such as dextrose in water or saline. Other possible carriers that may be used include ...
Cardioplegic Solutions by Baxter Heatlhcare. Manuf / Supplier: Baxter Healthcare. Z05-PF55022 Compare ...
Cardioplegic solution challenges.. *Philippe Menasché. *. Italian heart journal : official journal of the… ... Myocardial metabolism after hypothermic retrograde continuous blood cardioplegia with anterograde warm cardioplegic induction. ...
... and the cardioplegic solution is administered therethrough. The cardioplegic solution flows through the coronary arteries in ... Cardioplegic solutions, typically containing potassium, magnesium, procaine or a hypocalcemic solution, stop the heart by ... An auto-inflating cuff is filled by a flow of cardioplegic solution. Several methods are used to fill the auto-inflating cuff ... The occlusion of the left coronary vein prevents cardioplegic solution from leaking out of the coronary sinus proximal of the ...
0/Analgesics, Opioid; 0/Biological Markers; 0/Potassium Compounds; 0/Troponin I; 0/potassium cardioplegic solution; 27203-92-5/ ...
Potassium is the most common component in cardioplegic solutions. High extracellular potassium levels reduce the membrane ... Ringers solution and/or sugar solutions such as dextrose in water or saline. Other possible carriers that may be used include ... Carrier solutions may or may not be buffered.. Drug formulations or compositions may include antioxidants or preservatives such ... For example, the combination of drugs and vagal stimulation may be used as a cardioplegic agent in a variety of medical ...
Cardioplegic Solutions / pharmacology* * Diazoxide / pharmacology* * Drug Combinations * Female * Magnesium / pharmacology * ...
  • The effects of calsium (Ca) and magnesium (Mg) ions in cardioplegic solutions on intracellular calcium ion handling and cardioprotection during hypoxia and reoxygenation which simulated ischemia and reperfusion or during the arrest of contraction and recontraction under aerobic condition were investigated in cultured neonatal rat myocardial cells. (nii.ac.jp)
  • Khogali, SEO , Lyall, JA & Rennie, MJ 1998, ' Glutamine provides cardioprotection during reperfusion (but not during cardioplegia) after prolonged cardioplegic arrest with St Thomas's Solution in the isolated working rat heart ', Journal of Physiology , vol. 511, no. (dundee.ac.uk)
  • After 2 and 4 hours of arrest (cardioplegic solution delivered every 20 minutes for 2 minutes at 37°C), only 50% (4 of 8) and 14% (1 of 7) of St Thomas' Hospital solution hearts recovered aortic flow, respectively. (edu.au)
  • CONCLUSIONS: We conclude that adenosine and lidocaine polarizing cardioplegic solution confers superior cardiac protection during arrest and recovery compared with hyperkalemic depolarizing St Thomas' Hospital cardioplegic solution. (edu.au)
  • We tested a new polarizing normokalemic cardioplegic solution employing adenosine and lidocaine as the arresting, protecting, and preserving cardioprotective combination. (edu.au)
  • 05) after 2 and 4 hours in hearts arrested with adenosine and lidocaine cardioplegic solution compared with hearts arrested with St Thomas' Hospital solution. (edu.au)
  • 1. When Mg was not included in the cardioplegic solutions, the intracellular Ca concentration increased during hypoxia and reoxygenation and brought cell injury in ischemia model. (nii.ac.jp)
  • 2. The increase in intracellular Ca concentration during hypoxia and reoxygenation was suppressed by the addition of Mg independent of cardioplegic Ca concentration. (nii.ac.jp)
  • The findings suggest that in immature myocardium, the concentrations of Ca and Mg present in cardioplegic solutions influence intracellular Ca handling and cardioprotective effect. (nii.ac.jp)
  • 3. However, the perfusion of the low Ca cardioplegic solution in which the Mg concentration was high increased intracellular Ca concentration and cell injury during reoxygenation. (nii.ac.jp)
  • 4. The intracellular Ca concentration increased during recontraction only in the low Ca cardioplegic solution without Mg and did not increase in the other Ca and Mg concentrations under aerobic condition. (nii.ac.jp)
  • Publications] Takashi Ichiba: 'A study on regulation of intracellular calcium ion concentrations and cardioprotective effect by calcium and magnesium ions in cardioplegic solutions' The Journal of the Yonago Medical Association. (nii.ac.jp)
  • Using an isolated rat heart preparation, we evaluated anoxic injury occurring with cardioplegic solutions containing various concentrations of K+, ranging from 15 to 200 mEq. (elsevier.com)
  • Cardioplegia plays a critical role keeping the heart protected and arrested during cardiopulmonary bypass by maintaining a desired ratio of blood and cardioplegic solution at a prescribed temperature. (medtronic.com)
  • Currently established methods of tissue preservation for heart transplantation involve placing the harvested donor heart in a cold, nutrient-rich cardioplegic solution. (cornell.edu)
  • A system for cooling the heart using the actual blood of the patient has also been developed and the use of blood as the vehicle for delivery of the cardioplegic solution has the advantage of keeping the heart oxygenated while it is arrested for the surgery. (justia.com)
  • In addition, the administration of drugs along with the cold solution has more reliability and reproducibility in this system and apparatus to be disclosed and the mixing of the medication and blood can be achieved in a much more efficient manner than can be done in the batch system. (justia.com)
  • It is an object to provide a cardioplegic system which is more readily controlled and monitored and which enables the administration of the solution in a continuous fashion if desired as distinguished from the batch system. (justia.com)
  • Khogali, SEO , Lyall, JA & Rennie, MJ 1998, ' Glutamine provides cardioprotection during reperfusion (but not during cardioplegia) after prolonged cardioplegic arrest with St Thomas's Solution in the isolated working rat heart ', Journal of Physiology , vol. 511, no. (dundee.ac.uk)
  • Inadequate preservation solutions limit lung storage times and, consequently, transplant programs. (oup.com)
  • Brain-dead donor heart conservation with a preservation solution supplemented by a conditioned medium from mesenchymal stem cells improves graft contractility after transplantation. (uni-heidelberg.de)
  • Saitoh Y, Hashimoto M, Ku K, Kin S, Nosaka S, Masumura S, Nakayama K. Heart preservation in HTK solution: role of coronary vasculature in recovery of cardiac function. (medigraphic.com)
  • Impact of particulate contamination in crystalloid cardioplegic solutions: studies by scanning and transmission electron microscopy. (nih.gov)
  • Practicalities of delivering crystalloid cardioplegic solutions: Part II. (journals.co.za)
  • Sodium hydrosulfide improves the protective potential of the cardioplegic histidine buffer solution. (umassmed.edu)
  • In the other 92 patients, plegisol cardioplegic solution was used. (scirp.org)
  • In this study, we aimed to investigate whether there is a difference between two cardioplegic solutions, Plegisol and modified St Thomas' Hospital, in the frequency of ventricular fibrillation occurence after declamping of the aorta. (scirp.org)
  • Before 2011, plegisol cardioplegic solution was used in our clinic. (scirp.org)
  • Oxygenated blood, transferred from the oxygenator, was made cardioplegic by the dilution with 1:4 ratio of warmed crystalloid cardiopegia solution (Plegisol), and the addition of sufficient potassium chloride to bring the potassium concentration to about 25 mmol/L. Cardioplegic solution was infused through the aortic root after the cross-clamp. (ispub.com)
  • From patients who underwent CABG between 2011 and 2013, we carefully screened 253 from the same database and patient files and selected 144 patients (Group S, n = 144) who underwent CABG using St Thomas' Hospital cardioplegic solution. (scirp.org)
  • To evaluate perioperative results and long term survival in patients with severe left ventricular (LV) dysfunction undergoing coronary artery bypass grafting (CABG) using non-cardioplegic methods. (bmj.com)
  • From this database, the records of 4100 patients undergoing isolated CABG with non-cardioplegic methods between April 1990 and December 1999 were retrieved for analysis. (bmj.com)
  • The tested solution (LIRM) uses low doses of sodium channel blocker ( lidocaine ), potassium channel opener (cromakalin), and actin / myosin cross bridge inhibitor ( 2,3-butanedione monoxime). (bvsalud.org)
  • The purpose of this study was to compare the effects of the newly introduced procaine hydrochloride (PHC) containing cardioplegic solution (Shahid Ghazi Pharmaceutical Co. Tabriz, Iran) and lidocaine (L) in cardioplegic solution on post aortic clamp arrhythmia in coronary artery bypass graft surgery. (multicardia.com)
  • A total of 100 patient candidates for coronary intervention from October 2016 to March 2017 were divided into two groups and randomly assigned one of the two cardioplegic solutions that were only different in the antiarrhythmic solution contents of procaine hydrochloride and lidocaine. (multicardia.com)
  • The amount of particulate matter present in Bretschneider's cardioplegic solution (HTK) was assessed by laser-mediated particle counting. (nih.gov)
  • Publications] Takashi Ichiba: 'A study on regulation of intracellular calcium ion concentrations and cardioprotective effect by calcium and magnesium ions in cardioplegic solutions' The Journal of the Yonago Medical Association. (nii.ac.jp)
  • Overall, del Nido cardioplegic solution is a simple and safe cardioprotective strategy. (eurekalert.org)
  • CONCLUSIONS: iC-BCP is superior to the other cardioplegic solutions in increasing the phosphorylation of Bad, inhibiting the activation of caspase 3, and preventing apoptosis. (mendeley.com)
  • The myocardial protection provided by cardioplegic solution using buffered, isosmotic potassium (30 mEq. (biomedsearch.com)
  • Myocardial protection in total consisted of administration of one of these solutions via the aortic root (antegrade), along with topical slushed ice and systemic hypothermia (30˚C). All the patients had coronary artery disease with a varying degree of stenosis of the left anterior descending coronary artery. (scirp.org)
  • Myocardial protection during minimally invasive mitral valve surgery: strategies and cardioplegic solutions. (missouriperfusion.com)
  • Here we report the effects of hypothermic storage in EuroCollins solution, St Thomas' Hospital cardioplegic solution and a modified bicarbonate buffer solution. (oup.com)
  • Delayed Cardioplegic Reoxygenation Reduces Reoxygenation Injury in Cyanotic Immature Hearts," The Society of Thoracic Surgeons, 1998. (patentgenius.com)
  • Control hearts (n=6) were perfused for 120 minutes without cardioplegic ischemia. (mendeley.com)
  • Profound cardiac hypothenola (10 - 15�C) Is an essential component of most techniques used to provide myocardial protecdon when the aom is cross-clamped during open heart surgery_ Cardiac hypothermia is induced and maintained primarily by infusing cold cardioplegic solutions Inlo the beart. (journals.co.za)
  • The man was treated with cardioplegic solution during open heart surgery, and the FDA is concerned that other people may have also been exposed to this infection risk. (schmidtlaw.com)
  • Two transplant patients with Aspergillus fumigatus infection who were administered NECC cardioplegic solution during surgery have been reported. (schmidtlaw.com)
  • Cardioplegic solution is used to induce cardiac muscle paralysis during open heart surgery to prevent injury to the heart. (schmidtlaw.com)
  • Two of the more common types of cardioplegic solutions formulated with different concentrations of electrolytes and antiarrythmic agents have been used in cardiac surgery. (scirp.org)
  • In a presentation at the 96th AATS Annual Meeting, a team of cardiac surgeons presents the results of a prospective randomized clinical trial of pediatric surgery patients, comparing a new type of long-acting cardioplegia (heart stopping) solution to the standard short-acting agent that requires repeated dosing during surgery. (eurekalert.org)
  • On many of the key parameters measured, such as length of time needed for surgery and interruption of blood flow, the results favored the long-acting del Nido cardioplegic solution. (eurekalert.org)
  • At the 96th AATS Annual Meeting, cardiac surgeons present the results of a prospective, randomized trial of pediatric heart surgery patients that shows that the del Nido cardioplegia solution, a new, long-acting agent, offers significant advantages over conventional cardioplegia, including reduced cardiopulmonary bypass and aortic cross-clamp times and faster onset of action. (eurekalert.org)
  • This requires an initial dose of solution, followed by repeated dosing at 25-30 minute intervals during surgery. (eurekalert.org)
  • With patients who have undergone cardiac surgery, consider the possibility of residual effects of cardioplegic solutions. (medscape.com)
  • Is Human Atrial Natriuretic Peptide (hANP) Effective as an Additive to Cardioplegic Solution During Cardiac Surgery? (nii.ac.jp)
  • Some research supports creatine supplementation with cardioplegic solution in patients undergoing coronary artery surgery. (davidsnaturalmarket.com)
  • Technique The surgery was performed on the arrested heart using cardioplegic solution under moderate hypothermia. (deepdyve.com)
  • At this point in FDA's investigation, the sterility of any injectable drugs, including ophthalmic drugs that are injectable or used in conjunction with eye surgery, and cardioplegic solutions produced by NECC are of significant concern," the FDA said in a statement Monday. (wbur.org)
  • The state is now asking those facilities to contact all patients that received injectable drugs produced by the compounding center, or ophthalmic drugs used in conjunction with eye surgery and a cardioplegic solution. (fosters.com)
  • The next day, the FDA revised this after finding that only one of the patients was actually treated with a cardioplegic solution from NECC. (schmidtlaw.com)
  • and cardioplegic solutions produced by NECC are of significant concern. (medpagetoday.com)
  • This study shows that the modified St.Thomas' Hospital cardioplegic solution is preferred for avoiding ventricular fibrillation occuring just after declamping of the aorta. (scirp.org)
  • An improved method of using a single catheter to infuse blood to the heart, clamping the aorta and delivering a cardioplegia solution. (google.de)
  • In a second embodiment, a single catheter (90) can be positioned downwardly in the aorta to infuse blood via openings (82) into the ascending aorta proximate the subclavian artery, and deliver cardioplegia solution via the distal opening (72) downward toward the aortic base. (google.de)
  • 6. The method as specified in claim 1 wherein said cardioplegia solution is delivered into the aorta between the aortic valve and said catheter balloon. (google.de)
  • The del Nido solution was first proposed by researchers at the University of Pittsburgh in 1990. (eurekalert.org)
  • Patients were divided into two groups, group A (n=50) for del Nido cardioplegic and group B (n=50) for St. Thomas' II cardioplegia. (nepjol.info)
  • The FDA said today it is investigating one case of possible meningitis associated with an epidural injection of triamcinolone acetonide and two reports of fungal infection with Aspergillus fumigatus in two transplant patients who were given cardioplegic solution made by the company. (medpagetoday.com)
  • Clinically, the required cardioplegic solution volumes were slightly higher in PHC group. (multicardia.com)
  • However, large volumes of cardioplegic solution may be detrimental because of washout of adenine nucleotide degradation products that accumulate during ischemia, which limits recovery of adenosine triphosphate. (utmb.edu)
  • Nonetheless, non-cardioplegic methods have gained in popularity. (bmj.com)
  • The initial loading dose of THAM acetate 0.3 mol/L in the treatment of acidaemia may be estimated as follows: THAM (ml of 0.3 mol/L solution) = lean body-weight (kg) x base deficit (mmol/L). The maximum daily dose is 15 mmol/kg for an adult (3.5L of a 0.3 mol/L solution in a 70kg patient). (nih.gov)
  • Having established a suitable period for study, storage in EuroCollins, St Thomas' Hospital cardioplegic solution or bicarbonate buffer were compared. (oup.com)
  • 0.05) reduced in lungs stored for 6 h in modified bicarbonate buffer (0.026±0.008), EuroCollins solution (0.013±0.002) or St Thomas' Hospital solution (0.025±0.005) compared to unstored lungs (0.068±0.007). (oup.com)
  • Vascular resistance, (1.32±0.13 cmH 2 O/ml per min) in unstored lungs, was similar in lungs stored in St Thomas' Hospital solution but increased significantly in lungs stored in modified bicarbonate buffer (3.22±0.78 cmH 2 O/ml per min) or EuroCollins solution (4.66±0.57 cmH 2 O/ml per min). (oup.com)
  • Modified St Thomas' Hospital cardioplegic solution has been in use since 2011. (scirp.org)
  • We evaluated the efficacy of verapamil, a calcium-channel blocking agent, as an adjunct to standard crystalloid cardioplegic solution in animals with left ventricular hypertrophy subjected to myocardial ischemia during cardiopulmonary bypass. (mysciencework.com)
  • Calcium Chloride and Calcium Gluconate in Neonatal Parenteral Nutrition Solutions without Cysteine: Compatibility Studies Using Laser Light Obscuration Methodology. (bioportfolio.com)
  • There are no compatibility studies for neonatal parenteral nutrition solutions without cysteine containing calcium chloride or calcium gluconate using light obscuration as recommended by the United St. (bioportfolio.com)
  • the pump with the 50-ml syringe containing the cold cardioplegic solution. (visionforum.com)
  • After the aortic cross-clamp was applied, the cold blood cardioplegic solution with added potassium was administered with repeat doses at 20-30 minute intervals. (ctsnet.org)
  • More evaluation is necessary for an optimal cardioplegic solution development. (bvsalud.org)
  • Commonly used St. Thomas'II cardioplegic solution has to be repeated at short intervals, which may cause additional myocardial injury. (nepjol.info)