An operation that uses stimulated latissimus dorsi muscle (SKELETAL MUSCLE VENTRICLE) to assist cardiac function. The latissimus dorsi muscle is mobilized from the chest wall and moved into the thorax through the bed of the resected 2nd or 3rd rib. The muscle is then wrapped around the left and right ventricles and stimulated to contract during cardiac systole by means of an implanted burst-stimulator. (Stedman, 26th ed)
Sick Sinus Syndrome
A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Angioplasty, Balloon, Coronary
A technique utilizing a laser coupled to a catheter which is used in the dilatation of occluded blood vessels. This includes laser thermal angioplasty where the laser energy heats up a metal tip, and direct laser angioplasty where the laser energy directly ablates the occlusion. One form of the latter approach uses an EXCIMER LASER which creates microscopically precise cuts without thermal injury. When laser angioplasty is performed in combination with balloon angioplasty it is called laser-assisted balloon angioplasty (ANGIOPLASTY, BALLOON, LASER-ASSISTED).
Ventricular Function, Left
Respiratory Function Tests
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).
Journal Impact Factor
Foramen Ovale, Patent
Urinary Sphincter, Artificial
An artifical implanted device, usually in the form of an inflatable silicone cuff, inserted in or around the bladder neck in the surgical treatment of urinary incontinence caused by sphincter weakness. Often it is placed around the bulbous urethra in adult males. The artificial urinary sphincter is considered an alternative to urinary diversion.
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Neoplastic Stem Cells
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Embryonic Stem Cells
Dynamic cardiomyoplasty in patients with end-stage heart failure: anaesthetic considerations. (1/34)Dynamic cardiomyoplasty is used increasingly for patients with chronic heart failure, with approximately 500 cases having been performed. The latissimus dorsi muscle is prepared maintaining its vascular supply and the muscle flap is wrapped around the heart and connected to a cardiomyostimulator. The muscle is later stimulated synchronously with ventricular systole to augment the heart. Our experience of 22 patients with chronic heart failure (NYHA III-IV) undergoing dynamic cardiomyoplasty is described from the anaesthetist's point of view. Two patients are reported as case reports. The challenge is to manage patients with severely impaired left ventricular function, who do not obtain immediate benefit from the operation. Our experience supports the importance of early use of inotropic agents. (+info)
Cellular cardiomyoplasty improves survival after myocardial injury. (2/34)BACKGROUND: Cellular cardiomyoplasty is discussed as an alternative therapeutic approach to heart failure. To date, however, the functional characteristics of the transplanted cells, their contribution to heart function, and most importantly, the potential therapeutic benefit of this treatment remain unclear. METHODS AND RESULTS: Murine ventricular cardiomyocytes (E12.5-E15.5) labeled with enhanced green fluorescent protein (EGFP) were transplanted into the cryoinjured left ventricular walls of 2-month-old male mice. Ultrastructural analysis of the cryoinfarction showed a complete loss of cardiomyocytes within 2 days and fibrotic healing within 7 days after injury. Two weeks after operation, EGFP-positive cardiomyocytes were engrafted throughout the wall of the lesioned myocardium. Morphological studies showed differentiation and formation of intercellular contacts. Furthermore, electrophysiological experiments on isolated EGFP-positive cardiomyocytes showed time-dependent differentiation with postnatal ventricular action potentials and intact beta-adrenergic modulation. These findings were corroborated by Western blotting, in which accelerated differentiation of the transplanted cells was detected on the basis of a switch in troponin I isoforms. When contractility was tested in muscle strips and heart function was assessed by use of echocardiography, a significant improvement of force generation and heart function was seen. These findings were supported by a clear improvement of survival of mice in the cardiomyoplasty group when a large group of animals was analyzed (n=153). CONCLUSIONS: Transplanted embryonic cardiomyocytes engraft and display accelerated differentiation and intact cellular excitability. The present study demonstrates, as a proof of principle, that cellular cardiomyoplasty improves heart function and increases survival on myocardial injury. (+info)
Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. (3/34)BACKGROUND: We hypothesized that transfection of the gene for human hepatocyte growth factor (hHGF) combined with cellular cardiomyoplasty might regenerate the impaired myocardium. METHODS AND RESULTS: We used a ligation model of proximal left anterior descending coronary artery (LAD) of Lewis rats. Two weeks after LAD ligation, 3 different treatments were conducted: (1) neonatal rat cardiomyocytes group (10(6) cells, T group, n=11), (2) HVJ-liposomes bearing the hHGF gene group (H group, n=10), and (3) combined (T-H group, n=10). The injection site was the scar area of myocardial infarction. For control, culture medium was injected (C group, n=13). Echocardiography demonstrated that cardiac performance was significantly ameliorated in the T-H group 4 and 8 weeks after injection. Contrast echocardiography also showed a marked increase in myocardial perfusion in the T-H group but not in the other groups. In the T-H group, neovascularization and a marked reduction of fibrosis were observed histologically. In an immunohistochemical study, strong staining for beta(1)-integrin, alpha-, and beta-dystroglycan were found principally in the basement membrane of myocytes in the T-H group 8 weeks after transplantation, although there was weak immunoreactivity in the T group. CONCLUSIONS: hHGF gene transfection enhanced the cellular cardiomyoplasty possibly by stimulating angiogenesis, restoring the impaired ECM, and promoting the integration of the dissociated grafted myocytes. The combined effects might have lead to the improved cardiac performance. Thus, combined therapy may be a promising strategy for the treatment of heart failure caused by myocardial infarction. (+info)
Mechanical properties of the latissimus dorsi muscle after cyclic training. (4/34)Cardiomyoplasty is a procedure developed to improve heart performance in patients suffering from congestive heart failure. The latissimus dorsi (LD) muscle is surgically wrapped around the failing ventricles and stimulated to contract in synchrony with the heart. The LD muscle is easily fatigued and as a result is unsuitable for cardiomyoplasty. For useful operation as a cardiac-assist device, the fatigue resistance of the LD muscle must be improved while retaining a high power output. The LD muscle of rabbits was subjected to a training regime in which cyclic work was performed. Training transformed the fiber-type composition from approximately equal proportions of fast oxidative glycolytic (FOG) and fast glycolytic (FG) fibers to one composed of almost entirely of FOG with no FG, which increased fatigue resistance while retaining rapid contraction kinetics. Muscle mass and cross-sectional area increased but power output decreased, relative to control muscles. This training regime represents a significant improvement in terms of preserving muscle mass and power compared with other training regimes, while enhancing fatigue resistance, although some fiber damage occurred. The power output of the trained LD muscle was calculated to be sufficient to deliver a significant level of assistance to a failing heart during cardiomyoplasty. (+info)
Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair. (5/34)BACKGROUND: The muscle-specific MyoD family of transcription factors function as master genes that are able to prompt myogenesis in a variety of cells. The purpose of our study was to determine whether MyoD could induce primary cardiac fibroblasts, isolated from infarcted myocardium or pericardium, to undergo myogenic conversion in a clinically relevant approach. METHODS AND RESULTS: Primary rat fibroblasts from 7-day-old infarcted myocardium or normal pericardium were transfected by an E1/E3-deleted adenoviral vector carrying both a human MyoD cDNA driven by a CMV promoter and a green fluorescent protein (GFP) reporter gene driven by a second CMV promoter. Expression of MyoD caused myogenic differentiation of cultured fibroblasts, as defined by elongation and fusion into multinucleated myotubes, typical cross striation as identified by electron microscopy, and positive immunostaining for sarcomeric actin, fast myosin heavy chain (MHC), and actinin. The myogenic cells (1.5x10(6)) were transplanted into the infarcted myocardium 7 days after coronary artery occlusion. By 1 month after transplantation, the converted fibroblasts gave rise to a cluster of myogenic cells that in a few hearts occupied a large part of the scar with positive immunostaining for the myogenic proteins fast-MHC and sarcomeric actin. A few cells expressed the gap junction protein connexin 43 in a disorganized manner. There was no positive staining in the control hearts treated with injections of untreated fibroblasts or culture medium. CONCLUSIONS: Our work shows that it is possible to exploit the unique capacity of MyoD to activate myogenesis in fibroblasts ex vivo and to create a vast source of autologous myogenic cells for transplantation. (+info)
Experience in heart transplantation after dynamic cardiomyoplasty. (6/34)We report a case undergoing heart transplantation due to gradual progression of heart failure four years and one month after dynamic cardiomyoplasty. This case reports a 61-year-old man who received drug therapy after being diagnosed as having idiopathic dilated cardiomyopathy, but his heart failure progressed to New York Heart Association (NYHA) class III-IV, and heart transplantation was thought to be indicated. However, dynamic cardiomyoplasty was performed because this patient rejected heart transplantation. An implantable cardioverter/defibrillator (ICD) was implanted for postoperative ventricular arrhythmia. After that, his symptoms rapidly improved, but his heart failure gradually worsened two years after surgery and heart transplantation was performed four years and one month after dynamic cardiomyoplasty. Since transplantation he has had an uneventful postoperative course without rejection or complications. (+info)
Tissue engineering therapy for cardiovascular disease. (7/34)The present treatments for the loss or failure of cardiovascular function include organ transplantation, surgical reconstruction, mechanical or synthetic devices, or the administration of metabolic products. Although routinely used, these treatments are not without constraints and complications. The emerging and interdisciplinary field of tissue engineering has evolved to provide solutions to tissue creation and repair. Tissue engineering applies the principles of engineering, material science, and biology toward the development of biological substitutes that restore, maintain, or improve tissue function. Progress has been made in engineering the various components of the cardiovascular system, including blood vessels, heart valves, and cardiac muscle. Many pivotal studies have been performed in recent years that may support the move toward the widespread application of tissue-engineered therapy for cardiovascular diseases. The studies discussed include endothelial cell seeding of vascular grafts, tissue-engineered vascular conduits, generation of heart valve leaflets, cardiomyoplasty, genetic manipulation, and in vitro conditions for optimizing tissue-engineered cardiovascular constructs. (+info)
Percutaneous transvenous cellular cardiomyoplasty. A novel nonsurgical approach for myocardial cell transplantation. (8/34)OBJECTIVES: The study evaluated a nonsurgical means of intramyocardial cell introduction using the coronary venous system for direct myocardial access and cell delivery. BACKGROUND: Direct myocardial cell repopulation has been proposed as a potential method to treat heart failure. METHODS: We harvested bone marrow from Yorkshire swine (n = 6; 50 to 60 kg), selected culture-flask adherent cells, labeled them with the gene for green fluorescence protein, expanded them in culture, and resuspended them in a collagen hydrogel. Working through the coronary sinus, a specialized catheter system was easily delivered to the anterior interventricular coronary vein. The composite catheter system (TransAccess) incorporates a phased-array ultrasound tip for guidance and a sheathed, extendable nitinol needle for transvascular myocardial access. A microinfusion (IntraLume) catheter was advanced through the needle, deep into remote myocardium, and the autologous cell-hydrogel suspension was injected into normal heart. Animals were sacrificed at days 0 (n = 2), 14 (n = 1, + 1 control/collagen biogel only), and 28 (n = 2), and the hearts were excised and examined. RESULTS: We gained widespread intramyocardial access to the anterior, lateral, septal, apical, and inferior walls from the anterior interventicular coronary vein. No death, cardiac tamponade, ventricular arrhythmia, or other procedural complications occurred. Gross inspection demonstrated no evidence of myocardial perforation, and biogel/black tissue dye was well localized to sites corresponding to fluoroscopic landmarks for delivery. Histologic analysis demonstrated needle and microcatheter tracts and accurate cell-biogel delivery. CONCLUSIONS: Percutaneous intramyocardial access is safe and feasible by a transvenous approach through the coronary venous system. The swine offers an opportunity to refine approaches used for cellular cardiomyoplasty. (+info)
Feasibility of pacemaker therapy after dynamic cardiomyoplasty.
A 54-year-old man presented with total atrioventricular (AV) block 3 months after dynamic cardiomyoplasty was performed because of heart failure due to idiopathic dilated cardiomyopathy. Though the cardiomyostimulator acted as a back-up pacemaker, a
Left ventricular function changes after cardiomyoplasty in pat...
Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy.: Dynamic cardiomyoplasty has been reported in the treatment of
Nursing Care Plan - Cardiomyoplasty (Post-op) - Nursing Crib
Cardiomyoplasty is used when cardiac transplantation is not an option and the patient is asymptomatic at rest. The latissimus dorsum muscle is dissected free of its distal insertion and is wrapped around the heart. For the next 2 months, the muscle is stimulated with increasing frequency until it can contract in synchrony with each heartbeat. Six months after surgery, effects of an enhanced cardiac output should be evident.. ...
Cellular cardiomyoplasty: a new hope in heart failure? | Heart
Intramyocardial injections of cultured fetal cardiomyocytes after infarction in female rats in an ischaemia-reperfusion model increased ejection fraction at one month; male cells transplanted into the female hosts were identified at necropsy by detection of the Y chromosome using an in situ hybridisation technique.7 In a mouse model of doxorubicin induced global cardiomyopathy,8 local transplantation of fetal cardiomyocytes can also improve global function, suggesting the intervention of paracrine factors. Comparing intramyocardial injections of cultured fetal cardiomyocytes and allogenic fetal skeletal myoblasts after infarction in rats,9 the functional equivalence of these two types of cells was demonstrated with decreased cavity dilatation and increased ejection fraction of similar magnitude; this anti-remodelling effect was more pronounced for the lowest ejection fractions (, 40%) with an approximately 30% relative increase in ejection fraction without cavity dilatation. Similar results ...
Soltero, E. R.
New configuration of double cardiomyoplasty based on studies of the length-tension properties of the latissimus dorsi muscle. Journal of Thoracic and Cardiovascular Surgery. 1993 ...
Latissimus dorsi muscle - Wikipedia
The number of dorsal vertebrae to which it is attached varies from four to eight; the number of costal attachments varies; muscle fibers may or may not reach the crest of the ilium. A muscular slip, the axillary arch, varying from 7 to 10 cm in length, and from 5 to 15 mm in breadth, occasionally springs from the upper edge of the latissimus dorsi about the middle of the posterior fold of the axilla, and crosses the axilla in front of the axillary vessels and nerves, to join the under surface of the tendon of the pectoralis major, the coracobrachialis, or the fascia over the biceps brachii. This axillary arch crosses the axillary artery, just above the spot usually selected for the application of a ligature, and may mislead a surgeon. It is present in about 7% of the population and may be easily recognized by the transverse direction of its fibers. Guy et al. extensively described this muscular variant using MRI data and positively correlated its presence with symptoms of neurological ...
Surgical treatment of the failing heart<...
TY - JOUR. T1 - Surgical treatment of the failing heart. AU - Singh, R. R.. AU - Lisle, T. C.. AU - Kron, I. L.. PY - 2005/8/1. Y1 - 2005/8/1. N2 - Heart failure is one of the leading causes of hospitalization worldwide. Currently, most therapeutic strategies are aimed at resolving the acute exacerbation of failure, resulting in a high readmission rate. Despite significant advances in the medical treatment of heart failure, the results are far from perfect. Mortality remains high and hospitalization costly. Surgical management is still required for patients with end-stage heart failure. Unfortu-nately, its evolution has occurred in a less structured fashion. In addition to transplantation, strategies for the treatment of heart failure currently under investigation include implantation of pacemakers, left ventricular reconstruction, mitral valve repair, coronary revascularization, cardiomyoplasty and mechanical circulatory support. In the end however, the surgical management of patients with ...
ECG of the Week - 9th September 2013 - Interpretation - FOAMed Nederland
The patient had a Cardiomyoplasty procedure for severe heart failure. Skeletal muscle is wrapped around the heart and connected to a high frequency pacemaker which is also connected to the heart in order to trigger the pacemaker. Skeletal muscle is used to increase ejection fraction but is not the same as cardiac muscle. It is hard to make skeletal muscle have a full contraction just with one pacing spike as we do for pacing the heart. To make skeletal muscle contract you need to give it sustained high frequency contraction which in this patient was programmed for every second beat. If you made it every beat, the skeletal muscle would fatigue and be ineffective. ...
Stem Cells and Cancer Stem Cells, Volume 2 - Stem Cells and Cancer | M.A. Hayat | Springer
Therapeutic use of stem cells and cancer stem cells Repair of damaged tissues Cardiomyoplasty and osteogenic induction Use of stem cells for developing in
330635 | Stanford Health Care
In 10 dogs, a latissimus dorsi muscle (myograft) was neuroelectrically stimulated at 120 cycles/min for as long as 80 days. The higher thresholds and multiple lead penetrations required of direct muscle stimulation for muscle conditioning were avoided. Vascular delay and protective wrapping of the myograft in four dogs resulted in rapid seroma and fibrous sheath formation, which precluded further study. Of the six other myografts that were stimulated, two were used as functional right ventricular myoventriculoplasties and four were employed as neoventricle myografts with inflow and outflow valved conduits that were used to provide total pulmonary blood flow. Myoventriculoplasty produced functional enlargement of the right ventricle with synchronously contractile muscle. Neoventricles provided hemodynamically stable total pulmonary blood flow for as long as 20 hours, until internal chamber thrombus formed. Transpulmonary blood pressure generation by the neoventricle was found to be programmable ...
Muscles Used in a Lat Pulldown Machine | LIVESTRONG.COM
Strengthening your latissimus dorsi muscles might not provide the same level of excitement as having rock-hard abs or bulging biceps. Strong lats, however,...
M.D.O.D.: Arithmetic and English 101 for My Patients
I think the only time I had a near 10/10 moment was when I got that ovarian cyst last summer. . . I was rolling on the floor screaming, I couldnt move, and on top of all that both of my latissimus dorsi muscles were severely spasming and my blood sugar was running low because I hadnt gotten any protein (I suffer from hypoglycemia, so I was feeling faint and very nauseated). I actually nearly passed out and I dry-heaved a little before my mom finally heard me (I was in the basement of my grandparents house and they were outside on the porch) and came running to find me lying on the floor in the fetal position, screaming bloody murder.. ReplyDelete ...
Sit-up Board，Dumbbell Bench Home Sit-up Aids Bundle Waist Training Chest Muscles Abdomen Latissimus Dorsi Training Barbell |...
Sit-up Board，Dumbbell Bench Home Sit-up Aids Bundle Waist Training Chest Muscles Abdomen Latissimus Dorsi Training Barbell for sale in our portal. Get our expert, independent ratings and reviews and read the latest consumer reports.
ExRx.net : Latissimus Dorsi
The latissimus dorsi is a stronger shoulder adductor when the shoulder is somewhat externally rotated. It is a stronger shoulder extensor when the shoulder is neither internally or externally rotated. The latissimus dorsi does not extend the shoulder beyond anatomical position (shoulder hyperextension). In strict transverse extension, the latissimus dorsi is weak. Incidentally, the posterior deltoid is strongly involved in both shoulder hyperextension and transverse extension.. The biarticulate latissimus dorsi enters passive insufficiency through the completion of shoulder flexion and abduction when the scapula is more rotated upward, elevated and abducted. The biarticulate latissimus dorsi enters active insufficiency through the completion of shoulder adduction when the scapula is more rotated downward and depressed or through the completion of shoulder extension when the shoulder girdle is more protracted and depressed.. ...
Cardiac Procedures and Surgeries
The American Heart Association explains the various cardiac procedures and heart surgeries for patients, such as Angioplasty, Percutaneous Coronary Interventions, PCI, Balloon Angioplasty, Coronary Artery Balloon Dilation, Percutaneous Coronary Interventions, PCI, Balloon Angioplasty, Coronary Artery Balloon Dilation, Angioplasty, Laser Angioplasty, Artificial Heart Valve Surgery, Atherectomy, Bypass Surgery, Cardiomyoplasty, Heart Transplant, Minimally Invasive Heart Surgery, Radiofrequency Ablation, Stent Procedure, Transmyocardial Revascularization and TMR.
Incrementally applied static stretch over 3 weeks resulted in a 72 % increase in the weight of the in situ latissimus dorsi muscle in rabbits. True growth rather than tissue oedema was confirmed by increases in the protein content (130 %), the cross-sectional area of the type I fibres (30 %) and the muscle length (i.e. number of sarcomeres in series increased 25 %). Despite an increase in the proportion of fibres staining positive for the enzyme succinate dehydrogenase (SDH), the myosin ATPase stain showed no appreciable fibre type transformation. While total power output in the stretched muscle was unchanged, its maximum mass specific power output, as determined by oscillatory work loops, was decreased by 50 %. The cross-sectional area that was occupied by connective tissue increased from 15 to 19 % in the stretched muscles, with a concomitant increase in passive energy dissipation. Some incrementally stretched muscles were then allowed an additional 3 weeks of maintained stretch to determine ...
Bassett Collection Large Image - Lane Medical Library, Stanford University Medical Center
The skin and subcutaneous connective tissue have been removed from the right axilla. The axillary fascia (7) is continuous with the pectoral (1) and brachial fascia (3) and with the fascia which covers the serratus anterior and latissimus dorsi muscles ...
Hammer Strength.fitness equipment,home gym,Iso-Lateral Front Pulldown
Key Features: 1) Underhand grip position allows for neutral wrist positioning, while providing an ideal stimulus for training the Latissimus Dorsi 2) Large arc of motion is unique and provides a great
N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in...
TY - JOUR. T1 - N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts. AU - Lou, Xi. AU - Zhao, Meng. AU - Fan, Chengming. AU - Fast, Vladimir G.. AU - Valarmathi, Mani T.. AU - Zhu, Wuqiang. AU - Zhang, Jianyi. N1 - Funding Information: This work was supported by the National Institute of Health (NHLBI R01 grants: HL95077, HL114120, HL131017, and UO1 HL 134764) for J.Z. Publisher Copyright: © 2019 Published on behalf of the European Society of Cardiology. All rights reserved.. PY - 2020/3/1. Y1 - 2020/3/1. N2 - Aims: In regenerative medicine, cellular cardiomyoplasty is one of the promising options for treating myocardial infarction (MI); however, the efficacy of such treatment has shown to be limited due to poor survival and/or functional integration of implanted cells. Within the heart, the adhesion between cardiac myocytes (CMs) is mediated by N-cadherin (CDH2) and is critical for the heart to ...
Treatment of heart failure with autologous skeletal myoblasts<...
TY - JOUR. T1 - Treatment of heart failure with autologous skeletal myoblasts. AU - Chachques, Juan C.. AU - Cattadori, Barbara. AU - Herreros, Jesus. AU - Prosper, Felipe. AU - Trainini, Jorge C.. AU - Blanchard, Didier. AU - Fabiani, Jean Noël. AU - Carpentier, Alain. PY - 2002/11. Y1 - 2002/11. N2 - Background: The management of patients with heart failure is a daily challenge for cardiologists and cardiac surgeons. Pharmacotherapy, atrio-biventricular resynchronization, myocardial revascularization, valve repair techniques, latissimus dorsi cardiomyoplasty, acorn cardiac support device, heart transplantation and mechanical assist devices do not cover all the needs. The recent progress in cellular and molecular biology allows the development of new therapies for heart failure. Transplantation of Autologous Cells: One of the most innovative consists in the transplantation of autologous ex-vivo expanded cells into the myocardium for heart muscle regeneration. This approach is called cellular ...
The muscular axillary arch: An anatomic study and clinical considerations<...
TY - JOUR. T1 - The muscular axillary arch. T2 - An anatomic study and clinical considerations. AU - Rizk, Elias. AU - Harbaugh, Kimberly. PY - 2008/10/1. Y1 - 2008/10/1. N2 - OBJECTIVE: The muscular axillary arch is a musculotendinous structure that arises from the latissimus dorsi muscle and crosses the axilla before inserting to the humerus, brachial fascia, or coracoid process. Case reports have described the neurovascular compression symptoms caused by this anatomic variant and have reported that the symptoms can be relieved by division of the muscle. However, there has been little information published regarding this topic in the neurosurgical literature. METHODS: We evaluated 70 axillary dissections in 35 cadavers to assess for the presence of this anomaly. RESULTS: The muscular axillary arch was identified unilaterally in 3 (8.6%) of the 35 cadavers. All 3 arches arose from the anterior border of the latissimus dorsi muscle and inserted at a point along a line extending from the coracoid ...
core muscles diagram
Standing calf raise (isolation) 2. The bonus with this one is you also work the arms and back. The latissimus dorsi muscle is the widest and most powerful back muscle. This is the muscle that allows the trunk of your body to twist - this is controlled by the external oblique muscle on the opposite side of the direction that youre twisting. 1. You have frequent lower back pain. Abstract. Each of these 4 muscles has a different, yet important, role to play - so you want to make sure that your workouts train all of them effectively. The rectus abdominis is absolutely essential for maintaining good posture, and is primarily responsible for flexing the lumber spine (the movement of a sit-up or a crunch). If youve ever felt a tweak, pinch, or twinge when performing a … When we refer to core stability in the context of Dru Yoga we are implying the slight contaction and awareness of a few specific muscules within the lower and middle abdomen. Your core muscles are what allow you to rotate, resist ...
Diffusion of Botulinum Toxins
The diffusion characteristics of BoNT have been well studied in humans7-10 and animals11,12 using a variety of techniques, including compound muscle action potentials (CMAPs) and motor-evoked potentials,7 histological determination of glycogen-depleted muscles,13 acetylcholine esterase staining,14 muscle fiber diameter variability,15 and quantitative electromyography (EMG) measures of muscle activity.16. Evidence for diffusion comes from both animal and human studies. In a study using muscle biopsy to identify spread, Borodic et al.15 reported a diffusion gradient of BoNT/A over a distance of 30-45 mm from the point of injection into latissimus dorsi muscle of rabbits.14 The extent of denervation gradient or diffusion was dose dependent. Another study used neural cell adhesion molecule (N-CAM) staining to assess the diffusion of activity of equipotent doses of three BoNT/A formulations from the point of injection along the mouse hind limb. The results showed a similar time course of paralysis, ...
Bigger Faster Stronger, Third Edition: Master standard and sport-specific auxiliary lifts
Auxiliary lifts are special exercises that are sport specific and help prevent injuries common in a sport. Chin-ups and lat pull-downs would be sport-specific exercises for baseball players because the latissimus dorsi muscles of the upper back internally rotate the upper arms.
Pelagornis - Wikipedia
Pelagornis is a widespread genus of the prehistoric pseudotooth birds. These were probably rather close relatives of either pelicans and storks, or of waterfowl, and are here placed in the order Odontopterygiformes to account for this uncertainty. The fossil specimens show that P. miocaenus was one of the large pseudotooth birds, hardly less in size than Osteodontornis or the older Dasornis. Its head must have been about 40 cm (16 in) long in life, and its wingspan was probably more than 5 m (16 ft), perhaps closer to 6 metres (20 ft). Unlike in its contemporary Osteodontornis but like in the older Pseudodontornis, between each two of Pelagorniss large teeth was a single smaller one. Pelagornis differed from Dasornis and its smaller contemporary Odontopteryx in having no pneumatic foramen in the fossa pneumotricipitalis of the humerus, a single long latissimus dorsi muscle attachment site on the humerus instead of two distinct segments, and no prominent ligamentum collaterale ventrale ...
Recover Faster: Best Methods For Athletic Recovery | PowerPlay
Pneumatic Compression: Pneumatic compression refers to the method where a pump unit is connected to a joint or muscle wrap and pumping air into the wrap, compressing and releasing to stimulate blood flow. This is also referred to as intermittent or active compression, which pushes swelling and edema out of the injured site and to the bodys core so it can be disposed of through the lymphatic system. The PowerPlay® compression device also delivers cold therapy to provide even better pain and swelling relief ...
Cuts - Ribeye Cap Steak
Prepared from the Spinalis Dorsi/Multifidus Dorsi muscle from any Ribeye Roll item. To portion, slice the Ribeye Cap at a right angle to the grain or direction of muscle fibers ...
Evergel Handwraps found in: Evergel Hand Wraps, New! Printed Evergel Hand Wraps, Evergel Weighted Hand Wraps, Prime Evergel Hand Wraps, MMA Evergel..
Rehabilitation of Canine Forelimb Injuries - WSAVA2013 - VIN
Maintenance of cardiovascular fitness. Canine Forelimb Lameness & Biomechanics. The canine forelimb is a crucial weightbearing structure, taking approximately 60% of the dogs weight. The forelimb is used as a strut (Carrier, Deban, Fischbein 2008) but is also actively involved in propulsion in the dog (Williams, Wilson, Daynes, Peckham, Payne 2008). The forelimb is an intricate structure with complex muscular and soft tissue structures both within the thoracic limb and extrinsic attachments to the thorax. When diagnosing and rehabilitating canine forelimb lameness often the extrinsic structures are overlooked, and to achieve successful functional rehabilitation a holistic approach is important. Williams et al. (2008) has demonstrated that the extrinsic muscles pectoralis profundus and latissimus dorsi muscles in the greyhound contributed significantly to thoracic limb muscle mass and they are adapted to produce large amounts of work. Biceps brachii and triceps brachii not only generate high ...
Building Your Lats Through Proper Biomechanics
As noted above, the lattisimus dorsi muscle has a strong action in adduction of the humerus. Whenever we have our hands above our head, as with seated pulldowns or while doing pull-ups, due to the upward rotation of the scapula that accompanies glenohumeral abduction, the latissimus dorsi effectively downwardly rotates the scapula by pulling the entire shoulder girdle downward in active glenohumeral adduction. Since it is one of the most important extensor muscles of the humerus, it contracts powerfully in chinning and supinated pull-downs. Therefore, any exercise in which the arms are pulled down bring the latissimus dorsi into a full contraction. Basic rowing and pullover exercises with dumbbells or barbells are also good for latissimus dorsi development ...
Chin-up - Wikipedia
The chin-up (also known as a chin or chinup) is a strength training exercise. People frequently do this exercise with the intention of strengthening muscles such as the latissimus dorsi and biceps, which extend the shoulder and flex the elbow, respectively. It is a form of pull-up in which the range of motion is established in relation to a persons chin. In the 1970s and 1980s, the term chin-up not only included an overhand/pronated (palms away) grip, but some authors used it as the default meaning of the term, with an underhand/supinated (palms toward) grip called a reverse grip. Even in the 2010s chin-up still includes palms-away lifting. The term chin-up is still regularly used refer to pulling using an overhand-grip. Both pull-ups and chin-ups are among the best exercises for back and overall upper body conditioning. However, they target the muscles a bit differently. Both exercises will work the latissimus dorsi and biceps, but standard chin-ups-with an underhand ...
Tibia Dorsi Calf Machine | JUMPUSA.com
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Breast pseudotumoral radionecrosis as a late radiation-induced injury: a case report | Journal of Medical Case Reports | Full...
New therapies and treatment protocols have led to improved survival rates in many cancers. The improved rates are such that patients are now living long enough to experience some negative long-term side effects of the initial therapy. We report the case of a 65-year-old Caucasian woman who presented with a rare case of pseudotumoral radionecrosis, a late radiation-induced injury, after combined surgical and cobalt radiation therapy for the treatment of adenocarcinoma of the right breast. The patient underwent resection of this benign, yet progressively growing and painful tumor. A cosmetically satisfying result was achieved by reconstruction of the thoracic wall with a polypropylene mesh and a latissimus dorsi muscle flap. With improved overall survival, new management strategies for late side effects of therapy are becoming of crucial importance for affected patients. In the future, improving toxicity-free survival will be as important as achieving disease-free survival or local tumor control.
Humerus Anatomy : Bony Landmarks & Muscle Attachment » How To Relief
Greater Tubercle is a large, roughened area placed lateral to the head. The infraspinatus, supraspinatus, and teres minor muscles attach to this elevation.. Lesser Tubercle is a roughened area found medial to the greater tubercle. It serves as the insertion site subscapularis muscle.. Intertubercular Groove is a thin, longitudinal depression between the lesser and greater tubercles. This indentation, which is further designated the bicipital groove, is a way for the tendon of the long head of the biceps brachii. The teres major, pectoralis major, and latissimus dorsi muscles also attach here.. Anatomical Neck is a grooved constriction within the head and tubercles that serves as an attachment point for the articular capsule.. Surgical Neck is a region under the tubercles where the bone narrows and fractures often occur.. Shaft or also known as Body is the elongated, cylinder-shaped middle part of the bone. Its relatively smooth surface is the insertion point for muscles that influence the upper ...
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Standard medical evaluation of a vertebra, the ligamentum flavum at each visit, continued aerobic exercise was encouraged at several levels of estrogen and progesterone in diagnosis of pulseless electrical activity i.E., a pentobarbital on cerebral resuscitation techniques level of consciousness seizures apnea prolonged psychological effects and low back and forth, similar to a physician, they should never be clipped or cut, since shaving injures the apophyses of the high price they pay. If excess acid is applied, remove with talc, baking soda, or liquid stool into a balanced configuration of the cervical spine, the latissimus dorsi muscle in the current health care system and the central process axon that extends from the underlying valvular pathology and defacilitate viscerosomatic reflexes initiated in cases of uti. Astounding developments in medical research. No cyanosis, clubbing, or edema. Presence of chapman reflexes, viscerosomatic reflexes, such as dextromethorphan, pentazocine, ...
The fatty acid composition of longissimus dorsi muscle of Polish Lowland ram lambs fattening under overhead shelter versus...
The aim of the study was the comparison of fatty acid composition in longissimus dorsi muscle of ram lambs fattening under overhead shelter versus those in a barn. The maintenance did not influence on main fatty acid composition of muscle tissue. The muscle tissue of lambs reared under overhead shelter compared to these kept in the barn was characterized by significantly higher C10:0, C12:0 (P | 0.01) but higher C18:2, c9, t11(P | 0.05) content, which is desirable in human diet with regard to its peculiarities.
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A latissimus dorsi flap brings skin, fat, and muscle from the back to recreate the breast. Most women do not have sufficient back tissue to create a breast, so this approach often requires the placement of an implant as well.
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LetвЂ™s take a brief minute to tell apart between ejaculation (a.k.a. squirting sex that is during and lubrication. Lubrication is really a substance that is slippery because of the walls for the vagina whenever youвЂ™re aroused, while ejaculate is just a watery fluid expelled during intimate stimulation or orgasm, through the urethra the tube that transports urine through the bladder out from the human body.. Specialists arenвЂ™t completely certain where in actuality the fluid arises from, but research suggests that the SkeneвЂ™s glands (also called the paraurethral glands or urethral sponge) may take place. This pipe of muscle wraps across the urethra; as arousal builds, the compartments that are erectile up like a number of grapes filled up with fluid, based on Sheri Winston, composer of WomenвЂ™s Anatomy of Arousal: key Maps to Buried enjoyment. Where does the fluid result from? ItвЂ™s filtered out of the watery section of our bloodstream plasma and combines with ...
anatomyEXPERT - Muscles - developmental approach - Structure Detail
Muscles and their associated tendons come in a wide variety of shapes and sizes. The different shapes and sizes coupled with the relationships they form with one another, with the skeleton, and at the joints they cross create the large variety of musculoskeletal action that is such an integral part of the bodys function. It is also from the differences in shape and size that muscles derive their names. When the early anatomists began naming muscles they used a logical, descriptive approach. Understanding the logic behind the name can help you learn about the muscle. The characteristic features of a muscle name include adjectives and genitives that modify the noun muscle. Keep in mind that the full name of any muscle of the body begins with musculus, a masculine noun. The English language has dropped this from common usage and allows the adjective and the genitive that describe the muscle to stand alone as the English noun. For example, musculus latissimus dorsi becomes the latissimus dorsi ...
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Replace your missing pectoral muscle.. Polands Syndrome is a congenital condition predominant in men which is characterized by the absence of a large portion of the pectoralis muscle. The missing portion is most often part of the sternal musculature but may also include the surrounding muscles. In these cases it is not unusual for the nipples to be disproportionately small or even entirely absent.. If you are a man suffering from Polands Syndrome, we can restore the natural appearance of your chest. The most straightforward procedure we use to correct the chest wall deformity is placing a custom made silicone implant where the pectoralis major muscle would be. Depending on your particular condition, your physical features and health status, we can customize the many options available to ensure your results are optimized to your needs. For example, we may find that transferring the latissimus dorsi muscle from the back to replace the muscle in the chest would be more beneficial than using an ...
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Back ada banyak muscle, dan memerlukan banyak exercise untuk hit semuanya. Tapi yang paling mencuri tumpuan adalah latissimus dorsi dan teres major sebab ini akan membentuk kepak. Fungsi latissimus dorsi dan juga teres major adalah untuk shoulder adductors, maknanya untuk menarik lengan dari atas ke bawah (pikir macam buat wide grip lat pulldown), dan juga sebagai shoulder extensor bermakna pergerakan lengan dari hadapan ke belakang, (pikir macam buat narrow grip seated row dan close grip pulldown ...
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March 2004). "Cellular cardiomyoplasty: clinical application". Ann. Thorac. Surg. 77 (3): 1121-30. doi:10.1016/j.athoracsur. ... May 2003). "Right ventricular cardiomyoplasty: 10-year follow-up". The Annals of Thoracic Surgery. 75 (5): 1464-8. doi:10.1016/ ... November 2007). "Association between a cell-seeded collagen matrix and cellular cardiomyoplasty for myocardial support and ... February 2003). "Growth factors improve latissimus dorsi muscle vascularization and trophicity after cardiomyoplasty". The ...
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However a similar operation (cardiomyoplasty) was tried in the 1990s with disappointing results. In any case, it has ...
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... cardiomyoplasty MeSH E04.100.376.374 - heart arrest, induced MeSH E04.100.376.374.500 - circulatory arrest, deep hypothermia ... cardiomyoplasty MeSH E04.928.220.360 - heart arrest, induced MeSH E04.928.220.360.500 - circulatory arrest, deep hypothermia ...
... is a surgical procedure in which healthy muscle from another part of the body is wrapped around the heart to ... If cardiomyoplasty is successful and increased cardiac output is achieved, it usually acts as a bridging therapy, giving time ... Cellular cardiomyoplasty is a method which augments myocardial function and cardiac output by directly growing new muscle cells ... Cardiomyoplasty. Carpentier, Alain, 1933-, Chachques, Juan-Carlos., Grandjean, Pierre A., International Meeting on Dynamic ...
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Cardiomyoplasty - Wikipedia
Cardiomyoplasty is a surgical procedure in which healthy muscle from another part of the body is wrapped around the heart to ... If cardiomyoplasty is successful and increased cardiac output is achieved, it usually acts as a bridging therapy, giving time ... Cellular cardiomyoplasty is a method which augments myocardial function and cardiac output by directly growing new muscle cells ... Cardiomyoplasty. Carpentier, Alain, 1933-, Chachques, Juan-Carlos., Grandjean, Pierre A., International Meeting on Dynamic ...
Cellular cardiomyoplasty - Wikipedia
Late effects of cardiomyoplasty on left v... & related info | Mendeley
BACKGROUND: Dynamic cardiomyoplasty is a relatively new surgical procedure proposed for treatment of severe myocardial failure ... Late effects of cardiomyoplasty on left ventricular mechanics and diastolic filling.. *Bellotti G ... Dynamic cardiomyoplasty increased the maximal elastance (17 +/- 1 versus 21 +/- 1 mm Hg/cm, P = .006) and decreased the ... BACKGROUND: Dynamic cardiomyoplasty is a relatively new surgical procedure proposed for treatment of severe myocardial failure ...
Dynamic cardiomyoplasty. Preliminary experience
... Jan 1, 1994 , Magazine: Revista Española de Cardiología ... We believe that dynamic cardiomyoplasty is a safe and valid surgical procedure for some patients with end stage ... Six patients with end-stage heart failure and 2 patients with left ventricular aneurysm underwent dynamic cardiomyoplasty using ... The purpose of this study is to show our experience in clinical dynamic cardiomyoplasty. ...
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Cardiomyoplasty | definition of cardiomyoplasty by Medical dictionary
... cardiomyoplasty explanation free. What is cardiomyoplasty? Meaning of cardiomyoplasty medical term. What does cardiomyoplasty ... Looking for online definition of cardiomyoplasty in the Medical Dictionary? ... cardiomyoplasty. Also found in: Wikipedia. car·di·o·my·o·plas·ty. (kardē-ō-mīō-plastē), An operation that uses stimulated ... cardiomyoplasty. (kăr″ dē-ō-mī′ō-plăs″tē) Surgical implantation of skeletal muscle to either supplement or replace myocardial ...
Feasibility of pacemaker therapy after dynamic cardiomyoplasty.
... block 3 months after dynamic cardiomyoplasty was performed because of heart failure due to idiopathic dilated cardiomyopathy. ... Cardiomyoplasty*. Electrocardiography. Heart Block / physiopathology, therapy. Heart Failure / physiopathology, surgery, ... A 54-year-old man presented with total atrioventricular (AV) block 3 months after dynamic cardiomyoplasty was performed because ...
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... also called cardiomyoplasty techniques. The first of these is dynamic cardiomyoplasty, which uses the latissimus dorsi muscle ... 1998) Cellular cardiomyoplasty: state of the art, evaluation and future possibilities. Arch Mal Coeur 91:1429-1435. ... 1999) Cellular cardiomyoplasty improved diastolic properties of injured heart. J Surg Res 85:234-242. ... Another technique is molecular cardiomyoplasty, which is based on the transformation of non-myogenic into contractile cells or ...
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... ... during cellular cardiomyoplasty was evaluated. As a high-performance T1-weighted magnetic resonance imaging (MRI) cell tracking ... "The use of gadolinium-carbon nanostructures to magnetically enhance stem cell retention for cellular cardiomyoplasty." ... and value of using GNTs as a magnetic nanoparticle facilitator to improve cell retention during cellular cardiomyoplasty. ...
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New techniques for the study of cardiomyoplasty. Henry R. Halperin, Howard R. Levin, Elliot Mc Veigh, Peter Cho, William Curtis ... New techniques for the study of cardiomyoplasty. / Halperin, Henry R.; Levin, Howard R.; Veigh, Elliot Mc; Cho, Peter; Curtis, ... Fingerprint Dive into the research topics of New techniques for the study of cardiomyoplasty. Together they form a unique ... New techniques for the study of cardiomyoplasty. In Morucci JP, Plonsey R, Coatrieux JL, Laxminarayan S, editors, Proceedings ...
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Dynamic cardiomyoplasty requires the use of a unique pacing device, the Cardiomyostimulator, which has not received final U.S. ... Dynamic cardiomyoplasty has been investigated as an alternative to medical therapy or as an alternative/bridge to heart ... Dynamic cardiomyoplasty. Cardiol Clin. 1995; 13(1):121-4. PMID: 7796426. 4. Silverman NA. Invited letter concerning: clinical ... Dynamic cardiomyoplasty is a surgical technique that uses paced, conditioned skeletal muscle to reinforce the failing heart. ...
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en] The cardiomyoplasty procedure involves the use of a transformed skeletal muscle to augment cardiac pump function or to ... This data is mandatory for the safe manipulation of the muscle flap during cardiomyoplasty. Thirty human latissimus dorsi flaps ... Reference : Anatomical Rationale for Use of the Latissimus Dorsi Flap During the Cardiomyoplasty .... ... Anatomical Rationale for Use of the Latissimus Dorsi Flap During the Cardiomyoplasty Operation. ...
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Left ventricular function changes after cardiomyoplasty in pat...
Dynamic cardiomyoplasty has been reported in the treatment of ... Dynamic cardiomyoplasty has been reported in the treatment of ... Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy.: ... Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy.. Authors * Jatene, A D ... Thus cardiomyoplasty improves left ventricular function and may halt the steady evolution of severe cardiomyopathies. See more ...
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N2 - Cellular cardiomyoplasty (CCM), or introduction of immature cells into terminally injured heart, can mediate repair of ... AB - Cellular cardiomyoplasty (CCM), or introduction of immature cells into terminally injured heart, can mediate repair of ... Cellular cardiomyoplasty (CCM), or introduction of immature cells into terminally injured heart, can mediate repair of ... abstract = "Cellular cardiomyoplasty (CCM), or introduction of immature cells into terminally injured heart, can mediate repair ...
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Cellular cardiomyoplasty for myocardial infarction: a 2014 evidence-based update<...
Cellular cardiomyoplasty for myocardial infarction: a 2014 evidence-based update. Acta medica Indonesiana. 2014 Apr 1;46(2):150 ... Cellular cardiomyoplasty is considered a novel therapy, in which stem cells are used for cardiac repair. Stem cells are ... Cellular cardiomyoplasty is considered a novel therapy, in which stem cells are used for cardiac repair. Stem cells are ... Cellular cardiomyoplasty is considered a novel therapy, in which stem cells are used for cardiac repair. Stem cells are ...
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Two-stage cardiomyoplasty. US5611515. Apr 5, 1993. Mar 18, 1997. Boston Scientic Corporation. Bladder neck suspension procedure ... Oh et al., "The Effects Of Prosthetic Cardiac Binding And Adynamic Cardiomyoplasty In A Model Of Dilated Cardiomyopathy", The ... Kass et al., "Reverse Remodeling From Cardiomyoplasty in Human Heart Failure", Circulation, vol. 91, No. 9, pp. 2314-2318 (May ... Capouya et al., "Girdling Effect of Nonstimulated Cardiomyoplasty on Left Ventricular Function", The Society of Thoracic ...
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Two-step cardiomyoplasty with ventricular reduction. US5800528. Dec 29, 1995. Sep 1, 1998. Abiomed R & D, Inc.. Passive girdle ... Two-stage cardiomyoplasty. US5631040. May 19, 1995. May 20, 1997. Ngk Insulators, Ltd.. Method of fabricating a piezoelectric/ ... However, even though cardiomyoplasty has demonstrated symptomatic improvement, studies suggest the procedure only minimally ... Another technique for the treatment for late stage congestive heart failure is a cardiomyoplasty procedure. In this procedure, ...
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In Cardiomyoplasty (eds. A. Carpentier, J.C. Chachques and P.A. Grandjean), Bakken Reserach Center Series, volume 3, Futura ... In Biomechanical cardiac assist: cardiomyoplasty and muscle powered devices (ed. R.C.-J. Chiu), Futura Pub.Co., pp. 19-28. ... Introduction to the history and development of skeletal muscle plasticity and its clinical application to cardiomyoplasty and ...
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Cardiomyoplasty. Cardiomyoplasty involves the removal of muscle tissue from one part of the patients body, such as the back, ... In a typical cardiomyoplasty procedure, the patients latissimus dorsi muscle is removed and wrapped around the heart as a kind ... Cardiomyoplasty, cell therapy and gene therapy are highly experimental treatment methods that seek to slow the progression of ... Recent improved outcomes with better stimulator technology may offer hope for cardiomyoplasty as a treatment option, but only a ...
Stromal cells for cellular cardiomyoplastyCellular cardiomyoplasty with skeletal myoblastsMyocardial infarctionSkeletal muscleCardiomyopathyLatissimus dorsiMesenchymal stemMyoblastsTissueDynamicInvolvesHeart transplantClinicalStem cell thMyocardiumArrhythmiasFeasibilityReduction surgeryCellsSurgeryPacemakerLeftOutcomesMagneticMuscleObjectiveHumanMethodHopeSuccessfulPatientsTechniquesTreatment optionFunctionOptionManagement
Stromal cells for cellular cardiomyoplasty2
- Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. (nature.com)
- The scientists said: "Because marrow stromal cells can be obtained repeatedly by bone marrow aspiration and expanded vastly in vitro before being implanted or used as autologous [same patient] implants, and because their use does not call for immunosuppression, the clinical use of marrow stromal cells for cellular cardiomyoplasty [heart tissue regeneration] appears to be most advantageous. (stemcellresearch.org)
Cellular cardiomyoplasty with skeletal myoblasts1
- We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. (fujita-hu.ac.jp)
- Cellular cardiomyoplasty (CCM) is considered to be a novel therapeutic approach for post- myocardial infarction (MI) heart failure . (bvsalud.org)
- During a surgical procedure called dynamic cardiomyoplasty (CMP), physicians take a large skeletal muscle in the upper back and wrap it around the heart. (thefreedictionary.com)
- Dynamic cardiomyoplasty is a surgical technique that uses paced, conditioned skeletal muscle to reinforce the failing heart. (hcsc.net)
- en] The cardiomyoplasty procedure involves the use of a transformed skeletal muscle to augment cardiac pump function or to substitute for the heart after parietal resection. (uliege.be)
- Percutaneous intracoronary cellular cardiomyoplasty for nonischemic cardiomyopathy: clinical and histopathological results: the first-in-man ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) trial. (thefreedictionary.com)
- A 54-year-old man presented with total atrioventricular (AV) block 3 months after dynamic cardiomyoplasty was performed because of heart failure due to idiopathic dilated cardiomyopathy. (biomedsearch.com)
- Left ventricular function changes after cardiomyoplasty in patients with dilated cardiomyopathy. (mysciencework.com)
- In this investigation significant improvement of left ventricular function with dynamic cardiomyoplasty was demonstrated in patients with dilated cardiomyopathy or Chagas' disease for more than 1 year of follow-up. (mysciencework.com)
- Six patients with end-stage heart failure and 2 patients with left ventricular aneurysm underwent dynamic cardiomyoplasty using the latissimus dorsi muscle. (cun.es)
- The first of these is dynamic cardiomyoplasty, which uses the latissimus dorsi muscle wrapped around a deficient heart which is stimulated, but this procedure produces inconsistent and moderate objective haemodynamic effects. (bmj.com)
- In a typical cardiomyoplasty procedure, the patient's latissimus dorsi muscle is removed and wrapped around the heart as a kind of "girdle. (jarvikheart.com)
- In this work, the effectiveness of using Gadonanotubes (GNTs) with an external magnetic field to improve retention of transplanted adult mesenchymal stem cells (MSCs) during cellular cardiomyoplasty was evaluated. (rice.edu)
- 4,5 The first human cellular cardiomyoplasty was recently reported using autologous myoblasts, with encouraging results. (ahajournals.org)
- Cardiomyoplasty, cell therapy and gene therapy are highly experimental treatment methods that seek to slow the progression of heart failure, fortifying the damaged heart with new muscle tissue or tissue taken from elsewhere in the body. (jarvikheart.com)
- Cardiomyoplasty involves the removal of muscle tissue from one part of the patient's body, such as the back, to be grafted onto the heart in order to strengthen it. (jarvikheart.com)
- Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. (europa.eu)
- BACKGROUND: Dynamic cardiomyoplasty is a relatively new surgical procedure proposed for treatment of severe myocardial failure. (mendeley.com)
- Dynamic cardiomyoplasty increased the maximal elastance (17 +/- 1 versus 21 +/- 1 mm Hg/cm, P = .006) and decreased the systolic wall stress (253 +/- 17 versus 190 +/- 12 g/cm2, P = .029). (mendeley.com)
- Dynamic cardiomyoplasty. (cun.es)
- The purpose of this study is to show our experience in clinical dynamic cardiomyoplasty. (cun.es)
- We believe that dynamic cardiomyoplasty is a safe and valid surgical procedure for some patients with end stage cardiomyopathies as well as in association with Jatene's technique for the management of left ventricular aneurysms. (cun.es)
- In eight centers in the United States, Canada and Brazil, researchers performed the procedure - known as dynamic cardiomyoplasty - on 68 people with moderate heart failure. (thefreedictionary.com)
- Dynamic cardiomyoplasty involves wrapping a muscle removed from the left back around the lower, pumping chamber of the heart. (thefreedictionary.com)
- Feasibility of pacemaker therapy after dynamic cardiomyoplasty. (biomedsearch.com)
- Dynamic cardiomyoplasty is considered experimental, investigational, and/or unproven . (hcsc.net)
- Dynamic cardiomyoplasty has been investigated as an alternative to medical therapy or as an alternative/bridge to heart transplantation in patients with congestive heart failure, particularly given the shortage of donor hearts for transplant. (hcsc.net)
- UpToDate 2015 notes the following regarding dynamic cardiomyoplasty (8). (hcsc.net)
- Dynamic cardiomyoplasty has been reported in the treatment of severe myocardial failure. (mysciencework.com)
- Mechanism of cardiomyoplasty: Dynamic three-dimensional magnetic resonance reconstructions in chronic heart failure. (lifebridgehealth.org)
- 11) Misawa Y., Fuse K.: Dynamic cardiomyoplasty reduces myocardial oxygen consumption. (jichi.ac.jp)
- The procedure, called cardiomyoplasty , involves detaching one end of a muscle in the back, wrapping it around the heart, and then suturing the muscle to the heart. (thefreedictionary.com)
- A third technique is cellular cardiomyoplasty, which involves myogenic cell grafting within the myocardium to limit any consequences of the loss of contractile function of a damaged left ventricle. (bmj.com)
- Note: Other applications include heart transplant and cardiomyoplasty. (marketsandmarkets.com)
- A large, randomized clinical trial of cardiomyoplasty in New York Heart Association class III patients was prematurely terminated because of poor enrollment and modest clinical benefit. (hcsc.net)
Stem cell th1
- Coverage includes the tools and techniques of minimally invasive coronary artery bypass surgery, aortic valve repair, arrhythmia surgery, cellular cardiomyoplasty and stem cell therapy, and mechanical circulatory support, among other topics. (thefreedictionary.com)
- If cardiomyoplasty is successful and increased cardiac output is achieved, it usually acts as a bridging therapy, giving time for damaged myocardium to be treated in other ways, such as remodeling by cellular therapies. (wikipedia.org)
- Cellular cardiomyoplasty is a method which augments myocardial function and cardiac output by directly growing new muscle cells in the damaged myocardium (heart muscle). (wikipedia.org)
- Cellular cardiomyoplasty, or cell-based cardiac repair, is a new potential therapeutic modality in which progenitor cells are used to repair regions of damaged or necrotic myocardium. (wikipedia.org)
- Cellular cardiomyoplasty (CCM), or introduction of immature cells into terminally injured heart, can mediate repair of chronically injured myocardium. (elsevier.com)
- Background - Cellular cardiomyoplasty has been proposed as an alternative strategy for augmenting the function of diseased myocardium. (ahajournals.org)
- This lack of effect on mortality may be related to the fact that cardiomyoplasty does not address the underlying cardiac pathology, and patients remain at risk for lethal arrhythmias, a major cause of death in patients with congestive heart failure. (hcsc.net)
- These proof-of-concept studies support the feasibility and value of using GNTs as a magnetic nanoparticle facilitator to improve cell retention during cellular cardiomyoplasty. (rice.edu)
- Prior cardiac transplantation, left ventricular reduction surgery, cardiomyoplasty or left ventricular assist device. (mayo.edu)
- To resume, stem cells and delivery routes aforementioned are suitable for cardiomyoplasty as demonstrated safe with some degree of benefit for the patient. (wikipedia.org)
- Cellular cardiomyoplasty is considered a novel therapy, in which stem cells are used for cardiac repair. (ui.ac.id)
- The persistence of the engrafted hMSCs and their in situ differentiation in the heart may represent the basis for using these adult stem cells for cellular cardiomyoplasty. (ahajournals.org)
- Researchers hope that cellular cardiomyoplasty, the use of transplanted stem cells to replace lost heart muscle cells, will do what current treatments cannot: prevent heart muscle loss after heart attack. (rxpgnews.com)
- METHODS AND RESULTS: In this investigation, the late effects (16.5 +/- 4.8 months after surgery) of cardiomyoplasty on left ventricular mechanics and diastolic filling were studied in eight male patients (mean age, 45 +/- 7 years). (mendeley.com)
- Cardiomyoplasty requires the use of a unique pacemaker manufactured by Medtronic (the Cardiomyostimulator), which has not yet received approval from the U.S. Food and Drug Administration (FDA). (hcsc.net)
- In November 2011, a large group of collaborators at Minneapolis Heart Institute Foundation at Abbott Northwestern found no significant difference in left ventricular ejection fraction (LVEF) or other markers, between a group of patients treated with cellular cardiomyoplasty and a group of control patients. (wikipedia.org)
- Late effects of cardiomyoplasty on left ventricular mechanics and diastolic filling. (mendeley.com)
- CONCLUSIONS: Our detailed evaluation of left ventricular mechanics demonstrates that cardiomyoplasty has significant multiple beneficial effects on dilated myopathic heart. (mendeley.com)
- In the current case, we used an alternative approach for cellular cardiomyoplasty , which is actually a combination of two established techniques, and demonstrated an improvement in left ventricular contractility and myocardial perfusion supported by intracoronary hemodynamic measurements. (thefreedictionary.com)
- Surgical techniques to treat CHF like cardiomyoplasty , left partial ventriculectomy, and reconstruction of mitral valve complex did not bring substantial benefit. (thefreedictionary.com)
- Left ventricular function changes after cardiomyoplasty in pat. (mysciencework.com)
- Thus cardiomyoplasty improves left ventricular function and may halt the steady evolution of severe cardiomyopathies. (mysciencework.com)
- Furnary and colleagues reported on a multicenter trial of cardiomyoplasty in 68 patients, comparing outcomes to a non-randomized group of patients with heart failure. (hcsc.net)
- Recent improved outcomes with better stimulator technology may offer hope for cardiomyoplasty as a treatment option, but only a few investigators are pursuing it. (jarvikheart.com)
- We have been using magnetic resonance techniques to quantify stroke volume and the three-dimensional motion of the heart during cardiomyoplasty. (elsevier.com)
- Cardiomyoplasty is a surgical procedure in which healthy muscle from another part of the body is wrapped around the heart to provide support for the failing heart. (wikipedia.org)
- This data is mandatory for the safe manipulation of the muscle flap during cardiomyoplasty. (uliege.be)
- This study emphasizes that, due to macroscopic anatomic features and systematic intramuscular vascular distribution, the latissimus dorsi is probably the most suitable muscle for the purpose of cardiomyoplasty. (uliege.be)
- In Biomechanical cardiac assist: cardiomyoplasty and muscle powered devices (ed. (springer.com)
- Despite a paucity of objective hemodynamic evidence, cardiomyoplasty has been shown to subjectively improve functional status and symptoms. (elsevier.com)
- Reverse remodeling from cardiomyoplasty in human heart failure: external constraint versus active assist. (lifebridgehealth.org)
- Cellular cardiomyoplasty: a new hope in heart failure? (bmj.com)
- It should also be noted that this study focused on patients with Class III heart failure, since prior studies had shown an unacceptably high mortality rate among patients with Class IV heart failure undergoing cardiomyoplasty. (hcsc.net)
- 1 This has encouraged the development of new methods of biological assistance, also called cardiomyoplasty techniques. (bmj.com)
- Until now cardiomyoplasty has been a treatment option for adults only. (tum.de)
- Pressure-volume analysis of changes in cardiac function in chronic cardiomyoplasty. (lifebridgehealth.org)
- Cardiomyoplasty is used when cardiac transplantation is not an option and the patient is asymptomatic at rest. (nursingcrib.com)
- For these reasons, cardiomyoplasty is no longer performed for the management of heart failure (HF). (hcsc.net)