Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Cardiomyopathy, Restrictive: A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.Takotsubo Cardiomyopathy: A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.Cardiomyopathy, Hypertrophic, Familial: An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Cardiomyopathy, Alcoholic: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Arrhythmogenic Right Ventricular Dysplasia: A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.Diabetic Cardiomyopathies: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Myocarditis: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Heart Septum: This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Ventricular Outflow Obstruction: Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Heart: The hollow, muscular organ that maintains the circulation of the blood.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Cardiac Myosins: Myosin type II isoforms found in cardiac muscle.Peripartum Period: The period shortly before, during, and immediately after giving birth.Echocardiography, Doppler: Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.Ventricular Myosins: Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Sarcomeres: The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.Endomyocardial Fibrosis: A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Myosin Heavy Chains: The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Endocardium: The innermost layer of the heart, comprised of endothelial cells.Plakophilins: Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.Heart Transplantation: The transference of a heart from one human or animal to another.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Lamin Type A: A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Diastole: Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.Sarcoglycans: A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.Magnetic Resonance Imaging, Cine: A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.Desmoglein 2: A CALCIUM-dependent adhesion molecule of DESMOSOMES that also plays a role in embryonic STEM CELL proliferation.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Systole: Period of contraction of the HEART, especially of the HEART VENTRICLES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Glycogen Storage Disease Type IIb: An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Isolated Noncompaction of the Ventricular Myocardium: Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.Pregnancy Complications, Cardiovascular: The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.Desmin: An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.Dystrophin: A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Ventricular Dysfunction: A condition in which HEART VENTRICLES exhibit impaired function.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.Ablation Techniques: Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)Epicardial Mapping: Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.Tropomyosin: A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Ventricular Dysfunction, Right: A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.Connectin: A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.Myofibrils: The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .Mitochondria, Heart: The mitochondria of the myocardium.Bundle-Branch Block: A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.Electrophysiologic Techniques, Cardiac: Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Echocardiography, Doppler, Color: Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Coxsackievirus Infections: A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.Pericarditis, Constrictive: Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.Heart-Assist Devices: Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.Genetic Testing: Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.Echocardiography, Doppler, Pulsed: Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.IodobenzenesDesmocollins: A group of desmosomal cadherins with cytoplasmic tails that are divergent from those of classical CADHERINS. Their intracytoplasmic domains bind PLAKOGLOBIN; PLAKOPHILINS; and DESMOPLAKINS.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.LIM Domain Proteins: A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Desmoplakins: Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Noonan Syndrome: A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.Receptors, Adrenergic, beta-1: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.Desmosomes: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Ventricular Pressure: The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Carbazoles: Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Dobutamine: A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.Ventricular Premature Complexes: A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Ventricular Septum: The muscular structure separating the right and the left lower chambers (HEART VENTRICLES) of the heart. The ventricular septum consists of a very small membranous portion just beneath the AORTIC VALVE, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum.Penetrance: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)Radionuclide Ventriculography: Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.Mitochondrial Myopathies: A group of muscle diseases associated with abnormal mitochondria function.Sarcoplasmic Reticulum Calcium-Transporting ATPases: Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.Heart Aneurysm: A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.Sports: Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Trypanosoma cruzi: The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.Enterovirus B, Human: A species of ENTEROVIRUS infecting humans and containing 36 serotypes. It is comprised of all the echoviruses and a few coxsackieviruses, including all of those previously named coxsackievirus B.Gadolinium DTPA: A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)Barth Syndrome: Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.Atrioventricular Block: Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.Enterovirus: A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Contrast Media: Substances used to allow enhanced visualization of tissues.Papillary Muscles: Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Body Surface Potential Mapping: Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Phonocardiography: Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.Gated Blood-Pool Imaging: Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).Angiocardiography: Radiography of the heart and great vessels after injection of a contrast medium.gamma Catenin: A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.Mice, Inbred mdx: A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.Gadolinium: Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.Ventricular Function, Right: The hemodynamic and electrophysiological action of the right HEART VENTRICLE.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Mice, Inbred C57BLSyndrome: A characteristic symptom complex.Fabry Disease: An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.LEOPARD Syndrome: An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Echocardiography, Stress: A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.Endocardial Fibroelastosis: A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.alpha-Crystallin B Chain: One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Pericardium: A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.Exercise Tolerance: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.Totiviridae: A family of RNA viruses that infect fungi and protozoa. There are three genera: TOTIVIRUS; GIARDIAVIRUS; and LEISHMANIAVIRUS.Cardiac Complexes, Premature: A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.Myocardial Stunning: Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.Organ Size: The measurement of an organ in volume, mass, or heaviness.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).Receptors, Adrenergic, beta: One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Cardiac Resynchronization Therapy: The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.Desmosomal Cadherins: A single-pass transmembrane glycoproteins that mediate CALCIUM-dependent CELL ADHESION and are core components of DESMOSOMES.Cardiotoxins: Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.Ventricular Function: The hemodynamic and electrophysiological action of the HEART VENTRICLES.

Clinical profile and outcome of idiopathic restrictive cardiomyopathy. (1/98)

BACKGROUND: Idiopathic restrictive cardiomyopathy is a poorly recognized entity of unknown cause characterized by nondilated, nonhypertrophied ventricles with diastolic dysfunction resulting in dilated atria and variable systolic function. METHODS AND RESULTS: Between 1979 and 1996, 94 patients (61% women) 10 to 90 years old (mean, 64 years) met strict morphological echocardiographic criteria for idiopathic restrictive cardiomyopathy, mainly dilated atria with nonhypertrophied, nondilated ventricles. None had known infiltrative disease, hypertension of >5 years' duration, or cardiac or systemic conditions associated with restrictive filling. Nineteen percent were in NYHA class I, 53% in class II, and 28% in class III or IV. Atrial fibrillation was noted in 74% of patients and systolic dysfunction in 16%. Follow-up (mean, 68 months) was complete for 93 patients (99%). At follow-up, 47 patients (50%) had died, 32 (68%) of cardiovascular causes. Four had heart transplantation. The death rate compared with actuarial statistics was significantly higher than expected (P<0.0001). Kaplan-Meier 5-year survival was 64%, compared with expected survival of 85%. Multivariate analysis using proportional hazards showed that the risk of death approximately doubles with male sex (hazard ratio [HR] = 2.1), left atrial dimension >60 mm (HR = 2.3), age >70 years (HR = 2.0), and each increment of NYHA class (HR = 2.0). CONCLUSIONS: Idiopathic restrictive cardiomyopathy or nondilated, nonhypertrophic ventricles with marked biatrial dilatation, as defined morphologically by echocardiography, affects predominantly elderly patients but can occur in any age group. Patients present with systemic and pulmonary venous congestion and atrial fibrillation and have a poor prognosis, particularly men >70 years old with higher NYHA class and left atrial dimension >60 mm.  (+info)

Differentiation between restrictive cardiomyopathy and constrictive pericarditis by early diastolic doppler myocardial velocity gradient at the posterior wall. (2/98)

BACKGROUND: The differential diagnosis between restrictive cardiomyopathy (RCM) and constrictive pericarditis (CP) is challenging and, despite combined information from different diagnostic tests, surgical exploration is often necessary. METHODS AND RESULTS: A group of 55 subjects (mean age, 63+/-11 years; 36 men and 19 women) were enrolled in the study; 15 had RCM, 10 had CP, and 30 were age-matched, normal controls. The diagnosis of RCM was supported by a biopsy; in the CP group, the diagnosis was confirmed either surgically or at autopsy. All patients underwent a transthoracic echocardiogram that included the assessment of Doppler myocardial velocity gradient (MVG), as measured from the left ventricular posterior wall during the predetermined phases of the cardiac cycle. MVG was lower (P<0.01) in RCM patients compared with both CP patients and normal controls during ventricular ejection (2. 8+/-1.2 versus 4.4+/-1.0 and 4.7+/-0.8 s(-1), respectively) and rapid ventricular filling (1.9+/-0.8 versus 8.7+/-1.7 and 3.7+/-1.4 s(-1), respectively). Additionally, during isovolumic relaxation, MVG was positive in RCM patients and negative in both CP patients and normal controls (0.7+/-0.4 versus -1.0+/-0.6 and -0.4+/-0.3 s(-1), respectively; P<0.01). During atrial contraction, MVG was similarly low (P<0.01) in both RCM and CP patients compared with normal controls (1.6+/-1.7 and 1.7+/-1.8 versus 3.8+/-0.9 s(-1), respectively). CONCLUSIONS: Doppler myocardial imaging-derived MVG, as measured from the left ventricular posterior wall in early diastole during both isovolumic relaxation and rapid ventricular filling, allows for the discrimination of RCM from CP.  (+info)

Sudden death and cardiovascular collapse in children with restrictive cardiomyopathy. (3/98)

BACKGROUND: Restrictive cardiomyopathy (RCM) is rare in children, and the prognosis is poor. In the present study, we evaluated all pediatric patients with RCM who were at our institution during a 31-year period to determine the clinical outcome and cause of death. Those who sustained sudden, unanticipated cardiac arrests were evaluated for risk factors that are predictive of sudden death. METHODS AND RESULTS: Eighteen consecutive patients were reviewed. Presentation, clinical course, laboratory data, and histopathological evidence of ischemia were compared between patients with and without sudden death events. The results demonstrated that patients who were at risk for sudden death were girls with chest pain, syncope, or both at presentation and without congestive heart failure. Although not statistically significant for sudden death, Holter monitor evidence of ischemia predicted death within months. Histopathological evidence of acute or chronic ischemia was found in the majority of patients, with acute ischemia more common among those who sustained sudden death events. CONCLUSIONS: All children with RCM are at risk for ischemia-related complications and death, and some are at risk of sudden death. In the present study, patients at risk of sudden death appeared well and had no evidence of ongoing heart failure but often had signs or symptoms of ischemia characterized by chest pain, syncope, or both. ECGs and Holter monitors may be useful screening tools. The use of beta-blockade, the placement of an implantable cardioverter-defibrillator, and preferential status 1A or B listing for cardiac transplantation are proposed for pediatric patients with RCM and evidence of ongoing ischemia.  (+info)

Heart transplantation and the Batista operation for children with refractory heart failure. (4/98)

Medically refractory heart failure may be present in children with cardiomyopathy (CMP) or complex congenital heart disease (CHD). In adults, the surgical management of this condition is either heart transplantation or the Batista operation. From March 1995 to January 2000, a total of 6 children, aged from 1 to 16 years, with medically refractory heart failure associated with CMP or complex CHD underwent cardiac transplantation and one of them also had the Batista operation as a bridge to transplantation. One of the 6 patients died of intractable sepsis 17 days after the operation, but the other 5 were discharged with satisfactory hemodynamics. Immunosuppressive agents, including azathioprine, cyclosporin or FK-506, were given. One patient experienced moderate acute rejection, but it was controlled by FK-506, OKT-3 and solumedrol. However, another suffered from lymphoproliferative disease 8 months after transplant, but it was controlled by intravenous immunoglubulin, alpha-interferon and acyclovir. Cardiac function during serial follow-up (range, 1 month to 5 years) revealed normal systolic and diastolic function and none received any anticongestive medications. Almost all patients received an oversized donor heart. The left ventricle (LV) mass was remodeled, initially as an decrease and later as an increase. The patient who underwent the Batista operation was discharged 1 month after the operation with an increased LV ejection fraction (from 10% to 22%). She was successfully bridged to heart transplantation 7 months after the Batista operation. The results of cardiac transplantation in growing children are satisfactory and remain the mainstay of surgical treatment for medically refractory heart failure in these patients. However, with a shortage of donor hearts, the Batista operation may be adopted as a bridge to heart transplant with a fair response.  (+info)

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. (5/98)

Stress-induced mitogen-activated protein kinase (MAP) p38 is activated in various forms of heart failure, yet its effects on the intact heart remain to be established. Targeted activation of p38 MAP kinase in ventricular myocytes was achieved in vivo by using a gene-switch transgenic strategy with activated mutants of upstream kinases MKK3bE and MKK6bE. Transgene expression resulted in significant induction of p38 kinase activity and premature death at 7-9 weeks. Both groups of transgenic hearts exhibited marked interstitial fibrosis and expression of fetal marker genes characteristic of cardiac failure, but no significant hypertrophy at the organ level. Echocardiographic and pressure-volume analyses revealed a similar extent of systolic contractile depression and restrictive diastolic abnormalities related to markedly increased passive chamber stiffness. However, MKK3bE-expressing hearts had increased end-systolic chamber volumes and a thinned ventricular wall, associated with heterogeneous myocyte atrophy, whereas MKK6bE hearts had reduced end-diastolic ventricular cavity size, a modest increase in myocyte size, and no significant myocyte atrophy. These data provide in vivo evidence for a negative inotropic and restrictive diastolic effect from p38 MAP kinase activation in ventricular myocytes and reveal specific roles of p38 pathway in the development of ventricular end-systolic remodeling.  (+info)

Epidemiology of idiopathic cardiomyopathy in Japan: results from a nationwide survey. (6/98)

OBJECTIVE: To estimate the total number of patients with idiopathic cardiomyopathy in Japan and the prevalence of the disorder. DESIGN: A nationwide epidemiological survey. SETTING: Hospitals selected randomly from among all hospitals in Japan. PATIENTS: Patients presenting with any of the three types of idiopathic cardiomyopathy: dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. MAIN OUTCOME MEASURES: The total number of patients in Japan was estimated using the sampling and response rates in each stratum with respect to hospital size. The second survey was conducted for patients reported in the first survey in order to obtain detailed information, including age, sex, and specific clinical data. RESULTS: Estimated patient totals and 95% confidence intervals (CI) were 17 700 (95% CI 16 500 to 18 800) for dilated cardiomyopathy, 21 900 (95% CI 20 600 to 23 200) for hypertrophic cardiomyopathy, and 300 (95% CI 250 to 350) for restrictive cardiomyopathy. Crude prevalence per 100 000 population was estimated as 14.0 for dilated cardiomyopathy, 17.3 for hypertrophic cardiomyopathy, and 0.2 for restrictive cardiomyopathy; crude incidence per 100 000 person-years was estimated as 3.58, 4.14, and 0.06, respectively. CONCLUSIONS: The total number and prevalence of patients with idiopathic cardiomyopathy in Japan are estimated for the first time in a nationwide survey. The prevalence of dilated cardiomyopathy in Japan appears to be about half that of Western populations, while that of hypertrophic cardiomyopathy is about the same.  (+info)

Molecular mechanisms of inherited cardiomyopathies. (7/98)

Cardiomyopathies are diseases of heart muscle that may result from a diverse array of conditions that damage the heart and other organs and impair myocardial function, including infection, ischemia, and toxins. However, they may also occur as primary diseases restricted to striated muscle. Over the past decade, the importance of inherited gene defects in the pathogenesis of primary cardiomyopathies has been recognized, with mutations in some 18 genes having been identified as causing hypertrophic cardiomyopathy (HCM) and/or dilated cardiomyopathy (DCM). Defining the role of these genes in cardiac function and the mechanisms by which mutations in these genes lead to hypertrophy, dilation, and contractile failure are major goals of ongoing research. Pathophysiological mechanisms that have been implicated in HCM and DCM include the following: defective force generation, due to mutations in sarcomeric protein genes; defective force transmission, due to mutations in cytoskeletal protein genes; myocardial energy deficits, due to mutations in ATP regulatory protein genes; and abnormal Ca2+ homeostasis, due to altered availability of Ca2+ and altered myofibrillar Ca2+ sensitivity. Improved understanding that will result from these studies should ultimately lead to new approaches for the diagnosis, prognostic stratification, and treatment of patients with heart failure.  (+info)

Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. (8/98)

Restrictive cardiomyopathy (RCM) is an uncommon heart muscle disorder characterized by impaired filling of the ventricles with reduced volume in the presence of normal or near normal wall thickness and systolic function. The disease may be associated with systemic disease but is most often idiopathic. We recognized a large family in which individuals were affected by either idiopathic RCM or hypertrophic cardiomyopathy (HCM). Linkage analysis to selected sarcomeric contractile protein genes identified cardiac troponin I (TNNI3) as the likely disease gene. Subsequent mutation analysis revealed a novel missense mutation, which cosegregated with the disease in the family (lod score: 4.8). To determine if idiopathic RCM is part of the clinical expression of TNNI3 mutations, genetic investigations of the gene were performed in an additional nine unrelated RCM patients with restrictive filling patterns, bi-atrial dilatation, normal systolic function, and normal wall thickness. TNNI3 mutations were identified in six of these nine RCM patients. Two of the mutations identified in young individuals were de novo mutations. All mutations appeared in conserved and functionally important domains of the gene. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org.  (+info)

A 16 year old male underwent evaluation for heart transplantation because of progressive dyspnoea, dizziness, and palpitations caused by restrictive cardiomyopathy of unknown aetiology which was unresponsive to conventional medical treatment. Idiopathic restrictive cardiomyopathy had been diagnosed at the age of less than 1 year and was associated with growth retardation, but no other overt congenital defects. During childhood and early adolescence the boy remained limited in his physical performance compared to his schoolmates. Since the autumn of 1997 progressive deterioration with dyspnoea and symptomatic arrhythmia such as atrial re-entry tachycardia or atrial flutter occurred and made further attendance of school almost impossible. Medical treatment was ineffective and, after clinical reassessment, the patient was put on the waiting list for heart transplantation in early 1998.. Echocardiographic examination at this time revealed the presence of biventricular diverticula located beneath the ...
Restrictive cardiomyopathy or simply RCM is the abnormal functioning of the heart muscles. Restrictive cardiomyopathy manifests itself differently to different people. While some may not experience any symptom whatsoever, there are those with reported severe symptoms. Know the causes, symptoms, treatment, prevention of restrictive cardiomyopathy
If youve ever woken up with stiff muscles, you know it can be hard to move around or perform your usual daily activities with the same ease. Similarly, our heart muscles need to stay flexible to do their job and pump blood throughout our bodies. Normally, the lower chambers of your heart open to let blood flow in and then contract to pump it back out. In restrictive cardiomyopathy, the heart muscle stiffens and is not able to stretch as it should to pump blood.. Restrictive cardiomyopathy can be caused by a number of things, including scarring of the heart from surgery and a condition called amyloidosis, where abnormal proteins build up in the heart. As restrictive cardiomyopathy progresses, you may develop heart failure. You may notice symptoms such as difficulty breathing at night or when exercising, feeling very tired, or swelling in your legs.. Treatment is usually focused on relieving symptoms and may include medications, lifestyle changes, and the use of a pacemaker to help regulate your ...
Restrictive cardiomyopathy, or restrictive cardiac disease, is defined as abnormal diastolic function in association with relatively well-preserved systolic function (at least in the early stages of the disease). Clinically, restrictive cardiomyopathy is difficult to distinguish from constrictive pericarditis, which is treatable.
Restrictive cardiomyopathy or infiltrative cardiomyopathy is a disorder of the heart muscle, in which the stiffened walls of the ventricles become resistant to adequate filling up with blood, when the heart relaxes (diastole) after every contraction, leading to heart failure.
... , or RCM, is when the chambers of the heart become stiffer over time. Though the heart is able to squeeze well, it is not able to relax between beats normally. This makes it harder for the heart to fill with blood. It also increases the pressure inside the ventricles and the atria can become enlarged.
TY - JOUR. T1 - Löeffler endocarditis and restrictive cardiomyopathy with biventricular apical thrombi. AU - Murata, Mitsushige. AU - Yasuda, Risako. AU - Tokuda, Hanako. AU - Suzuki, Keiko. AU - Tsuruta, Hikaru. AU - Yamada, Tatsuya. AU - Iwanaga, Shiro. AU - Kawamura, Akio. AU - Akaishi, Makoto. AU - Fukuda, Keiichi. PY - 2014/3. Y1 - 2014/3. UR - http://www.scopus.com/inward/record.url?scp=84894821905&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84894821905&partnerID=8YFLogxK. U2 - 10.1007/s12574-013-0199-4. DO - 10.1007/s12574-013-0199-4. M3 - Article. AN - SCOPUS:84894821905. VL - 12. SP - 46. EP - 47. JO - Journal of Echocardiography. JF - Journal of Echocardiography. SN - 1349-0222. IS - 1. ER - ...
Learn about child heart disease called restrictive cardiomyopathy including the causes, symptoms, diagnosis and treatment from St. Louis Childrens Hospital. Call us at 314.454.5437 for a physician referral.
TY - JOUR. T1 - Ventricular assistant in restrictive cardiomyopathy. T2 - Making the right connection. AU - Jaquiss, Robert D.B.. PY - 2016/1/1. Y1 - 2016/1/1. UR - http://www.scopus.com/inward/record.url?scp=84959556536&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84959556536&partnerID=8YFLogxK. U2 - 10.1016/j.jtcvs.2015.08.085. DO - 10.1016/j.jtcvs.2015.08.085. M3 - Comment/debate. C2 - 26395050. AN - SCOPUS:84959556536. VL - 151. SP - e15-e16. JO - Journal of Thoracic and Cardiovascular Surgery. JF - Journal of Thoracic and Cardiovascular Surgery. SN - 0022-5223. IS - 1. ER - ...
What are the symptoms for Restrictive cardiomyopathy? Doctor: shortness of breath, shortness of breath when lying flat, swelling, bilateral swelling, is your swelling present in the foot?
Relief is when you and the right researcher find each other Finding the right clinical trial for Familial restrictive cardiomyopathy 3 can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
some people with restrictive cardiomyopathy may get better by taking types of drugs called beta-blockers and ace inhibitors. if that doesnt ease your symptoms, your doctor may add other medicines lik
Restrictive cardiomyopathies (RCM) are indolent disabling diseases resulting from pathophysiologic processes that induce predominant diastolic chamber dysfunction with lesser impairment of systolic performance. RCM is characterized by small stiff ventricles with progressive impairment of diastolic filling, leading to the hemodynamic conundrum of low preload but high filling pressures (Figure 24-1). This pattern of diastolic dysfunction leads to dilated atria and elevated mean atrial pressures, resulting clinically in biventricular "backward failure" manifest as pulmonary venous congestion (dyspnea) as well as systemic venous pressure elevation (peripheral edema). Systolic function is preserved in most cases, depending on the underlying cause (at least in the presenting stages of most of the underlying diseases). However, despite intact systolic function, the restrictive constraints on true ventricular preload limit stroke volume, thereby resulting in low cardiac output (fatigue) and ultimately ...
Exome sequencing will be used as part of a tiered genetic analysis in a large cohort of up to 700 pediatric cardiomyopathy subjects with systolic (dilated cardiomyopathy) or diastolic (hypertrophic or restrictive cardiomyopathy) dysfunction. The biological parent(s) of enrolled participants will also be approached about participating and providing a blood sample for genetic testing. In addition to the parent(s), the participants siblings and other relatives may also be approached regarding enrollment, based on the pedigree and family history.. This study will significantly increase our understanding of pediatric cardiomyopathy by defining the prevalence of mutations in genes known to cause cardiomyopathy as well as identifying novel disease-causing genes in the pediatric population. Genetic association tests will identify variants that modify disease. Novel bioinformatics and systems biology applications for interpretation of exome level genetic information will contribute fundamental knowledge ...
Restrictive cardiomyopathies (RCMs) are a diverse group of myocardial diseases with a wide range of aetiologies, including familial, genetic and acquired diseases and ranging from very rare to relatively frequent cardiac disorders. In all these diseases, imaging techniques play a central role. Advan …
Extrinsic Cardiomyopathy are a more common type of Cardiomyopathy. It is where the primary pathology is outside the myocardium. Meanwhile, intrinsic Cardiomyopathy is defined as weakness inside the muscle of the heart. There are three more specific types of Cardiomyopathy. These are Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy and Restrictive Cardiomyopathy. Dilated Cardiomyopathy is the most common form. This form can lead to enlargement of the heart, especially the left ventricle, and the pumping function decreases. Hypertrophic Cardiomyopathy is when the muscle thickens, which can get in the way of the blood flow and prevents the heart to pump properly. Restrictive Cardiomyopathy is the most rarest form of Cardiomyopathy. It is when the walls of the ventricles stiffens but not thickens and can resist the normal filling of blood in the heart ...
http://library.med.utah.edu/WebPath/jpeg5/CV164.jpg Hemochromatosis, with excessive iron deposition, can occur in the heart as shown here microscopically with Prussian blue iron stain. The excessive deposition of iron leads to heart enlargement and failure similar to a cardiomyopathy, making hemochromatosis a form of restrictive cardiomyopathy.
DefinitionRestrictive cardiomyopathy refers to a set of changes in how the heart muscle functions. These changes cause the heart to fill poorly (more common) or squeeze poorly (less common). Sometimes, both problems are present.
Gives info on heart problem that leads to heart failure. Includes symptoms, diagnosis, and treatment with medicines, lifestyle changes, and surgery. Also info on causes like amyloidosis, hemochromatosis, and sarcoidosis. Includes info on tests. New Mexico, New Mexico
Gives info on heart problem that leads to heart failure. Includes symptoms, diagnosis, and treatment with medicines, lifestyle changes, and surgery. Also info on causes like amyloidosis, hemochromatosis, and sarcoidosis. Includes info on tests.
Thanks for visiting,. Carol and David DiFiori. In February, 2007, at age eight, Duncan was diagnosed with both CRF and restrictive cardiomyopathy. After nearly ten CRF-free years, we again resumed the role of caregivers. We rode the emotional roller coaster for nearly four years. We have written a journal about our experience with this unexpected diagnosis and the steps we took to help Duncan. Duncan brightened our lives with his happy-go-lucky, spirited, loving and affectionate personality. We have placed a photograph of Duncan in the Memorial Gallery and we have put a Tribute in the Tribute Gallery.. On July 4, 2012, we said goodbye to the sweetest, gentlest and most graceful cat there ever was. Joseph was Duncans littermate and brother and outlived him by a year and a half. We treasured every second with Joseph.. He, too, was diagnosed with both CRF and restrictive cardiomyopathy and other conditions. . His Memorial photo and Tribute are online.. Thank you for your beautiful, caring, ...
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Patients with heart failure can roughly be divided into two groups: those with ventricular dysfunction due to ischaemia and those with a non-ischaemic heart disease. Most of the different forms of cardiomyopathy in the last group can have a distinct cause like hypertension or a valvular heart disease. However in an important subset of these no such cause is identified thereby obtaining the classification "idiopathic" cardiomyopathy. The familial character of these different forms of idiopathic cardiomyopathy has been recognized in many studies.. Four categories of disease are distinghuised and the basis of haemodynamical and morphological characteristics: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC).. HCM is characterised by (usually asymmetric) left ventricular hypertrophy. In myocardial biopsies, myofibrillar disarray and myocyte hypertrophy is seen. Arrhythmias and premature sudden ...
Cardiomyopathies. Introduction. Define Cardiomyopathy Primary Cardiomyopathies Hypertrophic Cardiomyopathy ARVD Ion Channelopathies Dilated Cardiomyopathy Restrictive Cardiomyopathy Myocarditis Others Secondary Cardiomyopathies Infiltrative Disease. Evolving Definition. Slideshow...
Amongst adult cats, myocardial disease (cardiomyopathy) is the most common form of heart disease. Hypertrophic cardiomyopathy (HCM) is identified in over 60% of cardiomyopathic cats, with the rest attributable to dilated cardiomyopathy, restrictive cardiomyopathy (endomyocardial or myocardial), arrhythmogenic right ventricular cardiomyopathy, and "unclassified" cardiomyopathy.. The criteria by which each form of cardiomyopathy is defined are based on echocardiographically-derived parameters; however, there is some overlap between categories, which results in controversy over the classification of some individuals. Of greater importance for these individuals is correct identification of the type of functional abnormality (e.g., systolic dysfunction, diastolic dysfunction, or both), as this has direct implications for patient management.. While pathophysiology of the feline cardiomyopathies differs, affected cats are at risk for the same three adverse sequelae: congestive failure, thromboembolic ...
Morphologic features of the main types of cardiomyopathies. The normal geometry of the LV is shown. In comparison, there is enlargement and dilatation of the LV in DCM. In HCM, there is marked thickening of the LV wall, often asymmetric, with the septum being even thicker than the free wall of the LV. In restrictive cardiomyopathy (RCM), the ventricular wall may be normal, hypertrophic, or slightly dilated, but the main feature is that the restriction to diastolic compliance of the ventricl ...
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related troponin modifications on the Ca(2+) binding properties of the troponin complex and the reconstituted thin filament. The selected modifications are associated with a broad range of cardiac diseases: three subtypes of familial cardiomyopathies (dilated, hypertrophic and restrictive) and ischemia-reperfusion injury. Consistent with previous studies, the majority of the protein modifications had no effect on the Ca(2+) binding properties of the isolated troponin complex. However, when incorporated into the thin filament, dilated cardiomyopathy mutations desensitized (up to 3.3-fold), while hypertrophic and restrictive cardiomyopathy mutations, and ischemia-induced truncation of troponin I, sensitized the thin filament to Ca(2+) (up to 6.3-fold). Kinetically,
The Center for Pediatric Cardiomyopathy, Heart Failure and Transplantation at NewYork-Presbyterian/Morgan Stanley Childrens Hospital brings together the expertise of a wide range of pediatric heart specialists to care for your child. We have extensive experience taking care of children with complex congenital heart disease and severe heart disorders, such as cardiomyopathy and congestive heart failure.
Our study, which includes the largest series so far of patients with TTR-related CA comprehensively studied by both conventional echocardiography and 2D STI, supports the role of myocardial deformation imaging as a sensitive tool for characterizing LV dysfunction in CA over more traditional echocardiographic parameters. Our findings provide insights into the pathophysiological mechanisms underlining LV dysfunction in amyloid heart disease, suggesting a role for specific pathogenesis and LV wall thickness in determining LV dysfunction. Along with pathogenesis, LV LS was found to be an independent predictor of overall survival, confirming the previously observed prognostic significance of strain in patients with AL amyloidosis.. CA is commonly considered a form of restrictive cardiomyopathy, and the pathophysiology of HF has traditionally been attributed to diastolic dysfunction. Only a few studies have assessed the individual contributions of systolic and diastolic dysfunction to the ...
Mid June the Echocardiogram was reviewed and it was clear that the heart had worsened. The question was why. It could be idiopathic, amyloidosis, multiple myeloma or some other rare infiltrative process. It was time to break the silence. Barbie sent out an email to a few friends in California and Connecticut and we told our family. On July 1st, I informed my partners in our monthly meeting that I had restrictive cardiomyopathy and was waiting for a biopsy to determine if it was amyloidosis. I said I would continue to work. The news spread like wildfire. The response was overwhelming and somewhat difficult for me to adjust to. I was not accustom to being the individual in need; my role was always the opposite, to support others in their suffering. I did not want people to worry about me. This would begin a huge personal transformation in how I saw myself and the need to always be in control. This would be a very important life lesson for me.. I was scheduled for a fat biopsy and referred to the ...
Allison Lindgren knows the value of donating blood and vital organs. Having been diagnosed one year after birth with restrictive cardiomyopathy, the rarest form of heart disease, for which there is …
Allison Lindgren knows the value of donating blood and vital organs. Having been diagnosed one year after birth with restrictive cardiomyopathy, the rarest form of heart disease, for which there is …
Emily Smith got a needed heart transplant for her Restrictive Cardiomyopathy, but her sister Shayde continues to wait, reports Hari Sreenivasan. Harry Smith talks to the family.
Christopher had a successful heterotopic, or piggyback, heart transplant on Oct. 8,1997. He was born May 7, 1990 and was sick all his life with severe restrictive cardiomyopathy and secondary pulmonary hypertension. But, other than that, Christopher seemed healthy and just kept getting happier and happier with life. Our beautiful blond-haired, brown-eyed boy lifted his head, roiled over, crawled, walked and talked just like any other child. We decided to put off the transplant as long as he was doing okay. He was definitely our miracle child. He refused to give in to the heart disease. He was the joy of our lives. But you would never have known he was sick just looking at him or talking with him ...
Four and one half year old Izzy Grassano of Massapequa was recently diagnosed with Restrictive Cardiomyopathy. This is a disease that attacks the heart muscle. Because of this, the heart cannot fill adequately with blood and eventually loses the ability to pump properly. Izzy will be living at ...
Kinesin Family Member 20A) is a Protein Coding gene. Diseases associated with KIF20A include Familial Isolated Restrictive Cardiomyopathy. Among its related pathways are PLK1 signaling events and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ATPase activity. An important paralog of this gene is KIF23 ...
Jesica Santillan was a seventeen-year-old young lady who was born in Mexico with restrictive cardiomyopathy. Her parents paid smugglers 5,000 dollars to smuggle her and her two siblings over the Mexican-US border in order to obtain healthcare for her in the United States.. On their journey, the family was robbed by thieves who stole all of their money and even Jesicas earrings. They settled in North Carolina in a caravan, where her father and mother found work. Jesica came to be under the care of Dr James Jaggers, a very well respected surgeon and humanitarian at Duke University Hospital.. Soon after the Santillans arrived in North Carolina they drew the attention of compassionate locals like Mack Mahoney who became a fierce advocate for Jesica and her family, starting an organisation called Jesicas Hope Chest to raise funds for her surgery and the familys living expenses. He was such a trusted advocate for Jesica that her family allowed him to make surrogate medical decisions on her ...
The sarcomere is the principal contractile unit of striated muscle. Mutations in genes encoding sarcomeric proteins are responsible for a range of diseases including hypertrophic, dilated and restrictive cardiomyopathies and ventricular non-compaction. The downstream molecular pathways leading to these heterogeneous phenotypes include changes in acto-myosin cross-bridge kinetics, altered mechanosensation, disturbed calcium sensitivity, de-regulated signalling pathways, inefficient energetics, myocardial ischaemia and fibrosis. The elucidation of the genetic causes of cardiomyopathy has helped in understanding the structure and function of the sarcomere and a more detailed knowledge of the sarcomere and its associated proteins has suggested additional gene candidates. The new hope is that these advances will stimulate the discovery of disease-modifying drugs.. ...
Dr. Daniel Jacoby specializes in the diagnosis and treatment of heart failure and cardiomyopathy. Dr. Jacoby directs the Comprehensive Heart Failure Program. This program provides care for any and all patients at all stages of heart failure, from first diagnosis, to advanced disease requiring mechanical assist or transplant. Dr. Jacoby is the Founder and Director of the premier Cardiomypathy Program in the region, dedicated to serving the needs of patients, and families, living with the diagnosis of cardiomyopathy. Expert diagnosis and treatment of hypertrophic, dilated, arrhythmogenic and restrictive cardiomyopathies, as well as evaluation for causes of sudden cardiac death, are available through the Cardiomyopathy Program.. Dr. Jacoby has contributed widely to the literature of both heart failure and cardiomyopathy. His current bibliography can be accessed at: https://www.ncbi.nlm.nih.gov/sites/myncbi/1jcenq7Px5rkr/bibliography/43500476/public/?sort=date&direction=ascending. ...
Herkert JC, Verhagen JMA, Yotti R, Haghighi A, Phelan DG, James PA, Brown NJ, Stutterd C, Macciocca I, Leong K, Bulthuis MLC, van Bever Y, van Slegtenhorst MA, Boven LG, Roberts AE, Agarwal R, Seidman J, Lakdawala NK, Fernández-Avilés F, Burke MA, Pierpont ME, Braunlin E, ?aglayan AO, Barge-Schaapveld DQCM, Birnie E, van Osch-Gevers L, van Langen IM, Jongbloed JDH, Lockhart PJ, Amor DJ, Seidman CE, van de Laar IMBH. Expanding the clinical and genetic spectrum of ALPK3 variants: Phenotypes identified in pediatric cardiomyopathy patients and adults with heterozygous variants. Am Heart J. 2020 Jul; 225:108-119 ...
Reliability Centered Maintenance and Total Productive Maintenance presentation is intended to help as a 2-day workshop material for Operations and Maintenance personnel. This presentation consists of over 200 slides and comprises of the following: Group Activity - Define Maintenance Excellence Maintenance Excellence - Activity What is RCM? Objective & goal of RCM Techniques employed by RCM Primary RCM Principles Types of Maintenance Tasks RCM Considerations, Applicability + Benefits Steps in RCM Implementation TPM vision, definition, origins, principles 8 Pillars of TPM TPM Self-Assessment Autonomous maintenance Equipment & Process Improvement Equipment Losses, Manpower & Material Losses OEE - what it is & Calculations Activity OEE Calculation Other pillars of TPM TPM Implementation - 12 steps Benefits & OEE Tracker Proactive Maintenance Analysis Liaison with Ops, Communicating OEE, Group Activity - OEE Communication/Importance Ops. Skills, Cleanliness, Monitoring - Gauges,
Reliability Centered Maintenance and Total Productive Maintenance presentation is intended to help as a 2-day workshop material for Operations and Maintenance personnel. This presentation consists of over 200 slides and comprises of the following: Group Activity - Define Maintenance Excellence Maintenance Excellence - Activity What is RCM? Objective & goal of RCM Techniques employed by RCM Primary RCM Principles Types of Maintenance Tasks RCM Considerations, Applicability + Benefits Steps in RCM Implementation TPM vision, definition, origins, principles 8 Pillars of TPM TPM Self-Assessment Autonomous maintenance Equipment & Process Improvement Equipment Losses, Manpower & Material Losses OEE - what it is & Calculations Activity OEE Calculation Other pillars of TPM TPM Implementation - 12 steps Benefits & OEE Tracker Proactive Maintenance Analysis Liaison with Ops, Communicating OEE, Group Activity - OEE Communication/Importance Ops. Skills, Cleanliness, Monitoring - Gauges,
The pediatric heart experts at the Nemours Cardiac Center diagnose and treat restrictive cardiomyopathy (RCM) at Nemours/Alfred I duPont Hospital for Children in Wilmington, Del.
Parasternal short-axis (apical, mid, and basal segments) and apical 4-chamber views of the LV were recorded at end-expiration (60 to 110 frames/s) and probe frequency (range 1.7 to 2.0 MHz). To standardize short-axis image planes among the individuals, we identified the basal LV segment at the level of the mitral valve leaflet tips and the apical segment at the level just proximal to LV luminal obliteration at the end-systolic period. To obtain reliable LV 2D strain and rotation values, 3 consecutive heartbeats were digitally saved in cineloop format for later offline analysis with commercially available software (EchoPac 6.0.1 for PC, GE Healthcare). This software has been previously validated and allows accurate tracking acoustical markers (speckle patterns) on sequential echocardiographic images with correlation criteria and sum of absolute differences (13,14). The width for the region of interest was optimized to include at least 50% of the LV wall from the endocardial side. The software ...
Amyloidosis is a disorder resulting from the abnormal deposition of a particular protein in various tissues of the body. The four most common forms of amyloidosis are: (1) light chain due to immunoglobulins; (2) secondary which is seen in chronic inflammatory states such as rheumatoid arthritis; (3) senile which is typically seen in those over the age of 80; and (4) heriditary. There are at least eight different proteins that have been recognized to cause the hereditary amyloidoses [2]. Of these, the amyloidgenicTTR (ATTR) protein is the most common, with the Val30Met (Portuguese type) being the most prevalent mutation causing ATTR (80% of cases) [2]. The most common manifestation of ATTR is a neuropathy, but clinical manifestations vary depending on the location of the mutation. The treatment of hereditary amyloidosis is OLT, which limits further synthesis of the mutated protein, and thus halts further deposition in the organs. The Val30Met mutation typically presents with neuropathy, cardiac ...
Breathlessness is not a prominent symptom as the lungs are seldom congested. A raised jugular venous pressure is present, with a rapid and transitory y descent. The arterial pulse tends to be rapid, of small volume, and pulsus paradoxus may be present. Hepatomegaly and ascites occur relatively early compared with peripheral oedema. The heart is usually not enlarged but chest radiography may show pericaridal calcification. The main differential diagnosis is from restrictive myopathy. In countries where constrictive pericarditis is common the diagnosis is usually be made clinically. Where both constrictive pericarditis and restrictive cardiomyopathy are rare, and there is no pericardial calcification, cardiac catheterisation is indicated ...
Omics group organizes Pediatric Cardiomyopathy national symposiums, conferences across the globe in association with popular Pediatric Cardiomyopathy associations and companies. OMICS group planned its conferences, and events in america, europe, middle east and asia pacific. locations which are popular with international conferences, symposiums and events are china, canada, dubai, uae, france, spain, india, australia, italy, germany, singapore, malaysia, brazil, south korea, san francisco, las vegas, san antonio, omaha, orlando, raleigh, santa clara, chicago, philadelphia, baltimore, united kingdom, valencia, dubai, beijing, hyderabad, bengaluru and mumbai
Amyloidosis is a group of diseases that result from the extracellular deposition of amyloid, a fibrillar material derived from various precursor proteins that self-assemble with highly ordered abnormal cross β-sheet conformation (7). Amyloidosis is a multiorgan disease, that results in nonspecific symptoms, including dyspnea, weight loss, edema, proteinuria, bleeding tendency, orthostatic hypotension, and other features of autonomic or peripheral neuropathy. Cardiac involvement is the major determinant of survival. Deposition of amyloid fibrils in the extracellular space causes separation and distortion of the existing tissues and eventually causes irreversible cardiac dysfunction. This may occur in the myocardium, pericardium, small vessels and conduction system (20). When the myocardium is primarily affected, the ventricles may become stiff, leading to restrictive cardiomyopathy. The stiff ventricles may impair ventricular filling during diastole, leading to a clinical presentation of ...
Cardiovascular physical examination -- Heart murmurs and sounds -- Electrocardiography -- Chest x-ray -- Exercise stress testing -- Ambulatory electrocardiogram monitoring -- Echocardiography -- Nuclear cardiology -- Cardiac positron emission tomography -- Cardiac magnetic resonance imaging -- Cardiac computed tomography -- Swan-Ganz catheters and cardiac hemodynamics -- Coronary angiography and intracoronary imaging and physiologic assessment -- Chest pains and angina -- Chronic stable angina -- Non--ST-elevation acute coronary syndrome -- ST-elevation myocardial infarction -- Cardiogenic shock -- Percutaneous coronary intervention -- Coronary artery bypass surgery -- Myocarditis -- Dilated cardiomyopathy -- Heart failure with preserved ejection fraction -- Hypertrophic cardiomyopathy -- Restrictive cardiomyopathy -- Acute decompensated heart failure -- Heart failure : long-term management -- Heart transplantation -- Aortic stenosis -- Aortic regurgitation -- Mitral regurgitation -- Mitral ...
Endomyocardial fibrosis (EMF) is an idiopathic disorder of the tropical and subtropical regions of the world that is characterized by the development of restrictive cardiomyopathy. The nosology of EMF coincides with some related disorders.
Given the vital role of the ubiquitin-proteasome system (UPS) in result in restrictive cardiomyopathy in pigs (Herrmann et al., 2007; propelling the cell division cycle and sustaining cell survival, UPS inhibition is being intensively explored as a therapeutic strategy for treating malignancy, which is surely fueled by the impressive efficacy demonstrated by proteasome inhibitors bortezomib (BZM) and carfilzomib (CFZ) in treating multiple myeloma (MM) ((Chen-Scarabelli et al., 2017) and references therein). However, severe cardiovascular adverse effects such as sudden death, arrhythmia, angina, heart failure, and pulmonary hypertension to name a few, have been observed in MM patients treated with regimens containing BZM or CFZ ((Enrico et al., 2007, Chen-Scarabelli et al., 2017) and references therein). Most cardiovascular complications are reversible if the use of proteasome inhibitors is timely terminated but prematurely ceasing proteasome inhibitor treatment due to severe unintended effects will
TNNI3 patients may show pure RCM and HCM with or without restrictive pattern. Different phenotypes may coexist in the same family [4,8,9]. In the present family, as in other families observed in our centre with TNNI3-related cardiomyopathy, only the presence of a pure RCM without conduction disease in at least one member of the family seems to predict mutations of this gene. Differential clinical diagnosis includes pure restrictive phenotype caused by mutations of the Desmin gene, which are however characterized by the presence of atrioventricular block preceding the onset of restrictive haemodynamics and in some case, of clinically overt myopathy or increased sCPK. [6 ...
Cardiomyopathies are important causes of cardiac death in people and are responsible for arrhythmias and premature heart failure in all age groups. Although many cardiomyopathies are inherited, biochemical markers are a fundamental part of the diagnostic work-up and are useful in the prognostic and therapeutic assessment of disease. Excluding that of idiopathic DCM, there are various pathogenic pathways that can lead to DCM. Different pathways yield different biochemical substances that can be used as biomarkers. In this review, we mainly introduce some conventional and potential emerging biomarkers of dilated cardiomyopathy.. ...
Cardiomyopathy is a term used to refer to a group of heart disease disorders that are related to the heart muscle. There are 4 specific types of...
Principal Investigator:TOMITA Yoshifumi, Project Period (FY):1994 - 1996, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Circulatory organs internal medicine
The cardiomyopathies are a group of heart diseases that are defined by myocardial (heart muscle) dysfunction as the initial event.
Cardiomyopathies are an important cause of heart failure. For years they have been the Cinderella of cardiology, but in the last decade marked progress has been made in understanding their causes, be it genetic,1,2 inflammatory,3 or toxic.4 .... ...
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The term cardiomyopathy refers to a diseased state of the heart involving abnormalities of the muscle fibers, which contract with each heartbeat. Learn about the different types found in children.
Guidance on limiting non-essential planned surgeries and procedures, including dental, until further notice in order to to help address the demands of COVID-19 impacts.
Kussmaul sign is a paradoxical rise in jugular venous pressure (JVP) on inspiration, or a failure in the appropriate fall of the JVP with inspiration. It can be seen in some forms of heart disease and is usually indicative of limited right ventricular filling due to right heart dysfunction. Ordinarily the JVP falls with inspiration due to reduced pressure in the expanding thoracic cavity and the increased volume afforded to right ventricular expansion during diastole. Kussmaul sign suggests impaired filling of the right ventricle due to a poorly compliant myocardium or pericardium. This impaired filling causes the increased blood flow to back up into the venous system, causing the jugular vein distension (JVD) and is seen clinically in the internal jugular veins becoming more readily visible. The differential diagnosis generally associated with Kussmaul sign is constrictive pericarditis, as well as with restrictive cardiomyopathy. With cardiac tamponade, jugular veins are distended and typically ...
5. Genetic testing may be useful for patients with suspected Brugada syndrome (but not isolated type 2 or 3 pattern without signs/symptoms), short QT syndrome, arrhythmogenic cardiomyopathy meeting task force diagnostic criteria, dilated cardiomyopathy with a familial pattern (regardless of electrocardiogram findings), left ventricular noncompaction, and restrictive cardiomyopathy. The yield of testing in these circumstances tends to be less than the above conditions ...
Endocardial fibroelastosis (EFE) is a rare heart disorder usually occurring in children two years old and younger. It may also be considered a reaction to stress, not necessarily a specific disease. It should not be confused with endomyocardial fibrosis. EFE is characterized by a thickening of the innermost lining of the heart chambers (the endocardium) due to an increase in the amount of supporting connective tissue and elastic fibres. It is an uncommon cause of unexplained heart failure in infants and children, and is one component of HEC syndrome. Fibroelastosis is strongly seen as a primary cause of restrictive cardiomyopathy in children, along with cardiac amyloidosis, which is more commonly seen in progressive multiple myeloma patients and the elderly.[citation needed] A review cites references to 31 different diseases and other stresses associated with the EFE reaction. These include infections, cardiomyopathies, immunologic diseases, congenital malformations, even electrocution by ...
TY - JOUR. T1 - Cardiac Transplantation in a Pediatric Patient with Systemic Sclerosis. AU - Johnson, Jonathan N.. AU - Kvistad, Bonnie S.. AU - Reed, Ann M.. AU - Porter, Co Burn J. AU - OLeary, Patrick W.. AU - Driscoll, David J.. PY - 2013/1. Y1 - 2013/1. N2 - Introduction. Diffuse cutaneous systemic sclerosis (SSc) is rare in children, but has a poor prognosis when cardiomyopathy is present. Methods. We reviewed the case of a 14-year-old female with progressive skin thickening/tightness and dyspnea on exertion who was diagnosed with SSc. Results. Our patient was found to have severe restrictive cardiomyopathy with poor left ventricular systolic function (ejection fraction = 20%), unresponsive to the immunosuppression used to treat her SSc. There was no evidence of pulmonary fibrosis. The patient underwent orthotopic cardiac transplantation, with improvement in systemic symptoms. Two years after transplantation, she had elevated filling pressures during a surveillance catheterization, with ...
Genetic testing for potentially heritable cardiomyopathies has advanced from basic scientific discovery to clinical application. Nowadays, genetic diagnostic tests for cardiomyopathies are clinically available. As a consequence is fundamental the understanding of the clinical utility, in terms of diagnosis and prognosis, of genetic test results. In addition, the genetic counselling, regarding risks, benefits and options, is recommended for all patients and their relatives. However the relation between genotype and phenotype remains often unclear, and there is frequently a variance of uncertain significance. Consequently, the genetic test should always be approached as one component of a comprehensive cardio-genetic evaluation. This review aims to explore when genetic tests are indicated in patients with dilated and hypertrophic cardiomyopathy ...
Cathy Warwick the Chief Executive (CEO) of the Royal College of Midwives (RCM) will step down from the role to retire at the end of August 2017.. Cathy will be 65 in August and has been the RCMs CEO for over eight years having taken up the post in 2008.. Over the course of her tenure the RCM has seen its membership grow to its highest ever levels. She has been instrumental in directing internal modernisation at the RCM and enhanced services for members.. She has been central to positioning the RCM as an influential and collaborative organisation. The most recent example of this being her contribution to the Governments recently published Better Births Maternity Transformation Programme in England.. She has consistently championed real choice for women about how and where they give birth, and the need for high quality and safe services for women, babies and their families.. The RCM will now begin the search for a new CEO. Cathy will be working with the Board and the staff team at the RCM to ...
In an industry that has become increasingly demanding for healthcare providers, maintaining compliance across the revenue cycle is a critical task.
Figure 3. Delayed contrast enhancement short axis.. Conclusion: The CMR findings confirm, on one hand, the clinical suspicion of apical hypertrophic cardiomyopathy, by showing asymmetrically increased myocardial wall thickness of the apical region, with evidence of intramyocardial fibrosis of the hypertrophied segment. On the other hand, the study also shows the coexistence of a second pattern of DCE, characteristic, in this case, of endomyocardial fibrosis, involving both, the right and left ventricular apical regions.. Perspective: Idiopathic hypereosinophilic syndrome (HES) is rare and frequently involves the heart with development of endomyocardial fibrosis, a characteristic restrictive cardiomyopathy with uni- or biventricular endocardial fibrous tissue proliferation, preferably in the apical region and inflow tract, which leads to diastolic dysfunction and, not infrequently, to embolic phenomena arising from an overlying intracavitary thrombus.(1) Although the diagnosis was initially ...
PMCMP : Sudden cardiac death (SCD) is estimated to occur at an incidence of between 50 to 100 per 100,000 individuals in North America and Europe each year, claiming between 250,000 and 450,000 lives in the United States annually. In younger individuals (ages 15-35), the incidence of SCD is between 1 to 2 per 100,000 young individuals. Sudden cardiac death, particularly in young individuals, may suggest an inherited form of heart disease. In some cases of sudden cardiac death, autopsy may identify a structural abnormality such as a form of cardiomyopathy. Postmortem diagnosis of a hereditary cardiomyopathy may assist in confirmation of the cause and manner of death, as well as risk assessment in living family members.   The cardiomyopathies are a group of disorders characterized by disease of the heart muscle. Cardiomyopathies are often caused by inherited, genetic, factors. When the identified structural or functional abnormality observed in a patient cannot be explained by acquired causes,
In 1980, Hancock (10)described two forms of pericardial constriction, one being elastic and the other more analogous to a rigid shell. The fibroelastic form, he proposed, represents the acute or subacute phase of constriction. He noted that patients with subacute fibroelastic constriction present with more subtle signs and symptoms, rather than the classic findings seen in chronic CP. In many patients who are identified in the course of the initial pericardial inflammatory response, pericardial inflammation continues and pericardial fibrosis and calcification subsequently develop, leading to chronic (rigid) CP. However, as shown by this and other studies (1-4), in some patients the pericardial inflammation resolves without progressing to chronic CP. Thus, the subacute form of CP appears to be a reversible step in the progression to chronic CP.. Transient CP was originally described in the English literature by Sagrista-Sauleda et al. (1)in 1987. They reported the development of objective ...
Cardiomyopathy represents a collection of diverse conditions of the heart muscle. This course will highlight the main factors to the disease looking into the causes, symptoms, wants to prevent the infection including ways to treat it. This activity will also outline the key elements to pediatric cardiomyopathy
Autopsy shows ultrarunner had idiopathic cardiomyopathy.. Micah True, also known as Caballo Blanco from "Born To Run Fame" , who died in March while running in the wilderness of New Mexico, was found to have idiopathic cardiomyopathy, or heart disease with an unknown cause, said the Office of the Medical Investigator.. RELATED: White Horse Leads Caballo Blanco From Wilderness. After appearing in Christopher McDougalls best-selling book, True became an ultramarathoning legend. His popularity stemmed from spending months at a time in the Copper Canyon of New Mexico, where he befriended the Tarahumara tribe and started the Copper Canyon Ultramarathon. He was found dead on March 31. His body was found on the banks of a small stream with just his legs covered by water. He had been missing for days after heading out for a 12-mile run.. There were numerous abrasions on Trues extremities but no sign of internal injuries, the coroner said. The left side of his heart was found to be enlarged, and ...
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are two common cardiomyopathies with an estimated prevalence of 1:250 and 1:200 in adults (McKenna et al., 2017; Prondzynski et al., 2018). The prognoses of cardiomyopathies are poor, and the annual mortalities for DCM and HCM are 1.55% and 2.5%, respectively (Pelliccia et al., 2017; Vischer et al., 2009). During the past few decades, genetic screening has identified a list of autosomal inherited mutations as potential drivers or susceptible factors for cardiomyopathy, and approximately 40-50% of all cases can be attributed to genetic mutations (Zou et al., 2013; Paldino et al., 2018). Among these, genes coding sarcomere proteins are frequently found to be dysfunctional in both DCM and HCM, and it is estimated that around 30-40% DCM-associated mutations and 60% HCM-associated mutations occur in sarcomere genes (McNally et al., 2013; Hershberger et al., 2013; Veselka et al., 2017). Besides, mutations in a single sarcomere gene ...
Imaging plays a crucial role in the diagnosis, management, and prognosis assessment of patients with nonischemic cardiomyopathies. Over the past decade, the role of cardiovascular magnetic resonance imaging in clinical practice has been rapidly expanding. The techniques unsurpassed accuracy in defining cardiac morphology and function and ability to provide tissue characterization make it particularly well suited for the study of patients with nonischemic cardiomyopathies. In this review article, we provide an overview of the main cardiovascular magnetic resonance features of nonischemic cardiomyopathies, highlighting the diagnostic and prognostic utility of the technique in this heterogenous group of diseases.
Cardiomyopathies are disorders of the myocardium of unknown cause that are not associated with other disorders (figure 9-1). Specific heart muscle diseases, once known as secondary cardiomyopathies,...
cardiomyopathy - MedHelps cardiomyopathy Center for Information, Symptoms, Resources, Treatments and Tools for cardiomyopathy. Find cardiomyopathy information, treatments for cardiomyopathy and cardiomyopathy symptoms.
Definition Cardiomyopathies are diseases of the heart muscle (myocardium), in which the actual muscle cells and surrounding tissues are not normal or healthy. In this condition, the myocardium is abnormally enlarged, thickened and/or stiffened. Eventually, the weakened heart loses the ability to pump blood effectively and heart failure or heart ...
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Viral infections that infect the heart are a major cause of cardiomyopathy. In some instances, cardiomyopathy is a result of another disease or its treatment, such as complex congenital (present at birth) heart disease, nutritional deficiencies, uncontrollable, fast heart rhythms, or certain types of chemotherapy for cancer. Sometimes, cardiomyopathy can be linked to a genetic abnormality. Other times, the cause is unknown. Three types of cardiomyopathy typically affect adults.. ...
Symptoms of Cardiomyopathy dilated 1W including 7 medical symptoms and signs of Cardiomyopathy dilated 1W, alternative diagnoses, misdiagnosis, and correct diagnosis for Cardiomyopathy dilated 1W signs or Cardiomyopathy dilated 1W symptoms.
Family screening urgently needed to prevent early death in apparently healthy relatives Four in ten cardiomyopathies - a major cause of sudden cardiac...
The Heart Failure and Cardiomyopathies Cardiology Clinical Topic Collection gathers the latest guidelines, news, JACC articles, education, meetings and clinical images pertaining to its cardiovascular topical area - all in one place for your convenience.
Cardiomyopathy is a set of heart conditions. Treatment of cardiomyopathy includes treating the causes of the condition and treating the disorders brought on by cardiomyopathy.
Do You Have Dilated Cardiomyopathy? Join friendly people sharing 39 true stories in the I Have Dilated Cardiomyopathy group. Find support forums, advice and chat with groups who share this life experience. A Dilated Cardiomyopathy anonymous support g...
My family member aged 62 years has been diagnosed with |b|idiopathic dilated cardiomyopathy|/b|. An ECG, echo-cardiogram and subsequently cardio-angio-graph was done, EF was 35%. The doctor told us that the normal life for such patients is 6 months to 3 years, and another 3-4 years with a pacemaker. Is this true? My uncle had been diagnosed with dilated cardiomyopathy (with EF of 39%), when he was 45 years old. His reports are more or less similar, though the diagnosis was not idiopathic. Is this what is causing the difference in the prognosis? I have read reports on various web sites also which are not very hopeful. I am not able to understand the difference in the two cases.
The global cardiomyopathy medication market is expected to reach $ 1148.9 mn by the year 2026, at a CAGR of 2.1%. cardiomyopathy is an ailment of the heart muscle that makes it difficult for ones heart to pump blood to the other parts of the body.
Viral cardiomyopathy is a heart condition caused by a viral infection. Though viral cardiomyopathy can be treated, it can cause...
How is cardiomyopathy diagnosed? In some cases, cardiomyopathy does not have any presenting symptoms, particularly in the early stages. This is because the hear
The ALLMedicine™ Cardiomyopathy Center contains research, news, guidelines, drugs, clinical trials, and patient ed. Information related to Cardiomyopathy. Browse Now!
Has your dog recently been diagnosed with Dilated Cardiomyopathy? Learn more about the causes and treatment methods for Dilated Cardiomyopathy in dogs.
Any disease of the heart muscle that interferes with the hearts ability to pump blood with sufficient force is called cardiomyopathy.
The Cardiomyopathy information page was created to share information about genetic heart disease and the incidence of cardio in Scottish Folds.
Cardiomyopathy is a condition which makes it harder for the heart to pump and supply blood to the other parts of the body. Know its causes, symptoms, treatment.
In dilated cardiomyopathy (DCM) the main pumping chambers of the heart are enlarged (dilated) and contract poorly. This results in less blood being pumped around the body which fails to meet the bodys demand.
Puerperal cardiomyopathy information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
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Inquire for Dilated Cardiomyopathy Therapeutics Market 2017 Competitive Analysis, Trends and Forecast till 2022, with free sample copy of the report.
Learn more about Cardiomyopathy at St. Davids HealthCare DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision .....
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Hypertrophic cardiomyopathy, autosomal dominant mutations of TNNT2; hypertrophy usually mild; restrictive phenotype may be ...
Mutations in CRYAB could also cause restrictive cardiomyopathy. ER-anchored αBC can suppress aggregate formation mediated by ... mutation p.D109G causes restrictive cardiomyopathy". Human Mutation. 38 (8): 947-952. doi:10.1002/humu.23248. PMID 28493373. ...
... as well as with restrictive cardiomyopathy. With cardiac tamponade, jugular veins are distended and typically show a prominent ... low ventricular compliance Right heart failure Cardiac tumours Tricuspid stenosis Restrictive cardiomyopathy Pulmonary embolism ...
... cardiac disease due to cardiac fibrosis and restrictive cardiomyopathy; pulmonary airway and parenchymal disease; eosinophilic ...
It is contraindicated in cardiac tamponade and restrictive cardiomyopathy. The inotropic agent dobutamine is advised only in ... Patients with severe cardiomyopathy are at high risk for sudden cardiac death due to ventricular dysrhythmias. Although ICDs ... Phosphodiesterase inhibitors such as milrinone are sometimes utilized in severe cardiomyopathy. The mechanism of action is ... The RALES trial showed that the addition of spironolactone can improve mortality, particularly in severe cardiomyopathy ( ...
High blood pressure and restrictive cardiomyopathy are commonly observed.[citation needed] Angiokeratomas (tiny, painless ...
... which may be caused by diseases such as hypertensive cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, ... This includes patients with cardiomyopathy (hypertensive, hypertrophic, restrictive) and elderly individuals. Other factors ... in hypertrophic cardiomyopathy". Am. J. Cardiol. 70 (18): 1507-11. doi:10.1016/0002-9149(92)90313-N. PMID 1442632. Theodorakis ...
... mutations have been associated with restrictive, dilated and idopathic cardiomyopathy.; and recently, mutations were ... "Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant ... "Desmin mutation responsible for idiopathic dilated cardiomyopathy". Circulation. 100 (5): 461-4. doi:10.1161/01.cir.100.5.461. ... "De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy". Human Molecular Genetics. 19 ...
Yang SW, Hitz MP, Andelfinger G (Oct 2010). "Ventricular septal defect and restrictive cardiomyopathy in a paediatric TNNI3 ... Mutations in TNNI3K are associated to cardiomyopathies . GRCh38: Ensembl release 89: ENSG00000116783 - Ensembl, May 2017 GRCm38 ... atrial tachyarrhythmia and dilated cardiomyopathy". Human Molecular Genetics. 23 (21): 5793-804. doi:10.1093/hmg/ddu297. PMC ... expression of cardiac ankyrin repeat protein in human failing hearts due to arrhythmogenic right ventricular cardiomyopathy". ...
... including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM). The table below ... Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictive and dilated ... "Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene". Pediatrics. 117 (5): 1830-3. ... "Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes". Heart. 94 (11): ...
Infantile idiopathic restrictive cardiomyopathy,[175] and noncompaction of the left ventricular myocardium.[176] ... "Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes". Heart. 94 (11): ... such as Type 1R dilated cardiomyopathy and Type 11 hypertrophic cardiomyopathy. Certain defects of the atrial septum have been ... Kabaeva Z (2002). Genetic analysis in hypertrophic cardiomyopathy: missense mutations in the ventricular myosin regulatory ...
"Idiopathic restrictive cardiomyopathy in children is caused by mutations in cardiac sarcomere protein genes". Heart. 94 (11): ... Infantile idiopathic restrictive cardiomyopathy, and noncompaction of the left ventricular myocardium. ACTB is a highly complex ... such as Type 1R dilated cardiomyopathy and Type 11 hypertrophic cardiomyopathy. Certain defects of the atrial septum have been ... Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT (May 1998). "Actin mutations in dilated cardiomyopathy, a heritable form ...
However, in vivo evidence suggest that chronic activation of p38 MAPK activity triggers restrictive cardiomyopathy with limited ... "The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy". Proceedings of the National Academy ...
Mutations in MYPN have been linked to dilated cardiomyopathy, hypertrophic cardiomyopathy and restrictive cardiomyopathy. ... Specifics of these functions were gleaned from studies involving MYPN mutants associated with various cardiomyopathies. The ... "Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy". Cardiovascular Research. 77 (1): 118- ... "Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations". Human Molecular ...
"Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology ... "Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology ... Mutations in MYL3 have been identified as a cause of familial hypertrophic cardiomyopathy, and associated with a mid-left ... Mass spectrometry characterization of MYL3 at COPaKB GeneReviews/NIH/NCBI/UW entry on Familial Hypertrophic Cardiomyopathy ...
Hypertrophic cardiomyopathy, autosomal dominant mutations of TNNT2; hypertrophy usually mild; restrictive phenotype may be ...
These causes include: Constrictive pericarditis Restrictive cardiomyopathy, which includes Amyloidosis (most common restrictive ... Grade III and IV diastolic dysfunction are called "restrictive filling dynamics". These are both severe forms of diastolic ... This is referred to as "reversible restrictive diastolic dysfunction". Class IV diastolic dysfunction patients will not ... demonstrate reversibility of their echocardiogram abnormalities, and are therefore said to suffer from "fixed restrictive ...
restrictive vs. hypertrophic (presented below). Ischemic cardiomyopathy - Cardiomyopathy causing ischemia of the heart due to ... Nonischemic cardiomyopathy - Cardiomyopathy caused by something other than ischemia. Amyloid cardiomyopathy - Cardiomyopathy ... Restrictive cardiomyopathy (RCM) - Cardiomyopathy caused by excessive rigidity of the heart that prevents effective contraction ... Takotsubo cardiomyopathy (Transient apical ballooning, stress-induced cardiomyopathy) - A type of dilated cardiomyopathy caused ...
The differential diagnosis of Kussmaul's sign includes constrictive pericarditis, restrictive cardiomyopathy, pericardial ...
"Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy". Human Molecular Genetics. 20 (23): ... van Tintelen JP, Hauer RN (Jul 2009). "Cardiomyopathies: New test for arrhythmogenic right ventricular cardiomyopathy". Nature ... Erken H, Yariz KO, Duman D, Kaya CT, Sayin T, Heper AO, Tekin M (Oct 2011). "Cardiomyopathy with alopecia and palmoplantar ... Mutation of the JUP gene encoding plakoglobin has been implicated as one of the causes of the cardiomyopathy known as ...
Restrictive cardiomyopathy is defined as a disease of the heart muscle which results in impaired filling of the heart ... Loeffler endocarditis is a form of restrictive cardiomyopathy which affects the endocardium and occurs with white blood cell ...
In particular, restrictive cardiomyopathy has many similar clinical features to constrictive pericarditis, and differentiating ... "Restrictive pericarditis". eMedicine. MedScape. Retrieved 21 September 2015. "Imaging in Constrictive pericarditis". eMedicine ...
Hypertrophic Cardiomyopathy (HCM) Arrhythmogenic right ventricular dysplasia (ARVC) Dilated Cardiomyopathy (DCM) Restrictive ... cardiomyopathy (RCM) Myocarditis Coronary Artery Disease (CAD) Ion Channelopathies - Long QT syndrome (inc. Jervell and Lange- ...
A restrictive N-terminal truncation of cTnI occurs at low levels in normal hearts of all vertebrate species examined including ... Multiple mutations in cTnI have been found to cause cardiomyopathies. cTnI mutations account for approximately 5% of familial ... Restrictive N-terminal truncation: The approximately 30 amino acids N-terminal extension of cTnI is an adult heart-specific ... Distinct from the harmful C-terminal truncation, the restrictive N-terminal truncation of cTnI selectively removing the adult ...
... restrictive cardiomyopathy) and some make the heart prone to abnormal heart rhythms (arrhythmogenic cardiomyopathy). These ... Many cardiomyopathies can lead to heart failure in the later stages of the disease. Healthy heart valves allow blood to flow ... Some cardiomyopathies such as hypertrophic cardiomopathy are linked to a higher risk of sudden cardiac death, particularly in ... Cardiomyopathies are diseases affecting the muscle of the heart. Some cause abnormal thickening of the heart muscle ( ...
... dilated cardiomyopathy, Charcot-Marie-Tooth disease, Restrictive dermopathy and Hutchinson-Gilford progeria syndrome. A ... LMNA-Related Dilated Cardiomyopathy. 19 September 2013. PMID 20301717. NBK1674.. In GeneReviews *OMIM Cardiomyopathy, Dilated, ...
... restrictive cardiomyopathy is difficult to distinguish from constrictive pericarditis, which is treatable. ... or restrictive cardiac disease, is defined as abnormal diastolic function in association with relatively well-preserved ... encoded search term (Imaging in Restrictive Cardiomyopathy) and Imaging in Restrictive Cardiomyopathy What to Read Next on ... Although patients with idiopathic heart disease present with restrictive cardiomyopathy, the term restrictive cardiomyopathy ...
... can be caused by a number of things, including scarring of the heart from surgery and a condition ... In restrictive cardiomyopathy, the heart muscle stiffens and is not able to stretch as it should to pump blood. ... As restrictive cardiomyopathy progresses, you may develop heart failure. You may notice symptoms such as difficulty breathing ... Use this condition center to learn more about restrictive cardiomyopathy. You can keep up with the latest research, find ...
Idiopathic restrictive cardiomyopathy had been diagnosed at the age of less than 1 year and was associated with growth ... The association of biventricular diverticula with restrictive cardiomyopathy, however, has not been described so far. ... Pathologic anatomic examination of the explanted heart confirmed the diagnosis of idiopathic restrictive cardiomyopathy, and ... Restrictive cardiomyopathy with massive enlargement of both atria, an increase in left ventricular wall thickness, and a ...
When patients with restrictive cardiomyopathy were compared with those with constrictive pericarditis the significant ... Restrictive cardiomyopathy and constrictive pericarditis: non-invasive distinction by digitised M mode echocardiography. ... Restrictive cardiomyopathy and constrictive pericarditis: non-invasive distinction by digitised M mode echocardiography. ... It is difficult to distinguish between restrictive cardiomyopathy and constrictive pericarditis on the basis of clinical ...
Restrictive cardiomyopathy manifests itself differently to different people. While some may not experience any symptom ... Know the causes, symptoms, treatment, prevention of restrictive cardiomyopathy ... Restrictive cardiomyopathy or simply RCM is the abnormal functioning of the heart muscles. ... What is Restrictive Cardiomyopathy?. Restrictive cardiomyopathy or simply RCM is the abnormal functioning of the heart muscles ...
Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy. / Topilsky, Yan; Pereira, ... Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy. Circulation: Heart Failure ... title = "Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy", ... T1 - Left ventricular assist device therapy in patients with restrictive and hypertrophic cardiomyopathy ...
Restrictive cardiomyopathy refers to a set of changes in how the heart muscle functions. These changes cause the heart to fill ... Restrictive cardiomyopathy may affect either or both of the lower heart chambers (ventricles). Restrictive cardiomyopathy is a ... Restrictive cardiomyopathy refers to a set of changes in how the heart muscle functions. These changes cause the heart to fill ... People with restrictive cardiomyopathy may be heart transplant candidates. The outlook depends on the cause of the condition, ...
Restrictive cardiomyopathy (RCM) happens when the heart muscle becomes rigid and unable to relax and fill with blood. Learn the ... Restrictive Cardiomyopathy (RCM) What is Restrictive Cardiomyopathy?. Cardiomyopathy is a disease that affects the heart muscle ... In restrictive cardiomyopathy (RCM) the heart muscle becomes rigid and unable to relax and fill with blood. The function or ... To make an appointment or to learn more about treatment of Restrictive Cardiomyopathy at Cincinnati Childrens, please call 844 ...
some people with restrictive cardiomyopathy may get better by taking types of drugs called beta-blockers and ace inhibitors. if ... What medications can help with treating restrictive cardiomyopathy?. ANSWER Some people with restrictive cardiomyopathy may get ... Should people with restrictive cardiomyopathy exercise?. NEXT QUESTION: What medications can help with treating arrhythmia ...
... is a rare disorder in children that is characterized by restrictive filling and reduced diastolic volume of one or both ... pure restrictive cardiomyopathy, (2) hypertrophic-restrictive cardiomyopathy, and (3) mildly dilated restrictive cardiomyopathy ... encoded search term (Pediatric Restrictive Cardiomyopathy) and Pediatric Restrictive Cardiomyopathy What to Read Next on ... Restrictive cardiomyopathy (RCM) is a rare disorder in children that is characterized by restrictive filling and reduced ...
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice. ...
Restrictive Cardiomyopathy. Skip to the navigation Topic Overview. What is restrictive cardiomyopathy?. Restrictive ... What can you expect with restrictive cardiomyopathy?. Most of the time, restrictive cardiomyopathy leads to heart failure. ... that can lead to restrictive cardiomyopathy. But these diseases can be treated to prevent restrictive cardiomyopathy. ... What causes restrictive cardiomyopathy?. Often the cause is never found. But we do know that there are a number of diseases or ...
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the body. Treatment aims to ... Restrictive Cardiomyopathy: This condition is associated with increased stiffness of the heart.. Symptoms include palpitation. ... Cardiomyopathy is classified into three morphologic types: dilated, restrictive, and hypertrophic. When the exact cause is not ... Hypertrophic Cardiomyopathy. Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle (myocardium). ...
Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy.. Muchtar E1, Blauwet LA1, ... The restrictive cardiomyopathies are a heterogenous group of myocardial diseases that vary according to pathogenesis, clinical ... Restrictive cardiomyopathy (RCM) is characterized by nondilated left or right ventricle with diastolic dysfunction. ... Restrictive Cardiomyopathy - Genetic Alliance. *Cardiomyopathy - Genetic Alliance. *Familial restrictive cardiomyopathy - ...
Restrictive cardiomyopathy (RCM) is a form of cardiomyopathy in which the walls of the heart are rigid (but not thickened). ... Reduced QRS voltage on EKG may be an indicator of amyloidosis-induced restrictive cardiomyopathy. Treatment of restrictive ... "Restrictive Cardiomyopathy Treatment & Management". 2014-12-18. Retrieved 2015-06-10. Pollak, A; Falk, R H (1993-08-01). "Left ... "The novel αB-crystallin (CRYAB) mutation p.D109G causes restrictive cardiomyopathy". Human Mutation: n/a-n/a. doi:10.1002/humu. ...
Restrictive cardiomyopathy. Restrictive cardiomyopathy is a problem in which the heart muscle becomes stiff and cannot fully ... A number of diseases can lead to restrictive cardiomyopathy. Sometimes the cause is not known. Symptoms of restrictive ... In most cases, restrictive cardiomyopathy leads to heart failure. Heart failure means that your heart cant pump enough blood ... You may also have treatment for the cause of the cardiomyopathy. Treatment may include medicine and lifestyle changes. ...
Synonyms and Keywords: Infiltrative cardiomyopathy; RCM Overview. Restrictive cardiomyopathy is the least common cardiomyopathy ... In time, restrictive cardiomyopathy patients develop heart failure. Causes. Life Threatening Causes. Life-threatening causes ... There are no known life threatening causes of restrictive cardiomyopathy that may result in death within 24 hours if not ... Shown below is an example of restrictive cardiomyopathy with low voltage and flipped anterior T waves. ...
What is restrictive cardiomyopathy? Meaning of restrictive cardiomyopathy medical term. What does restrictive cardiomyopathy ... Looking for online definition of restrictive cardiomyopathy in the Medical Dictionary? restrictive cardiomyopathy explanation ... constrictive cardiomyopathy, Dilated cardiomyopathy. Restrictive Cardiomyopathy. Definition. Cardiomyopathy is an ongoing ... restrictive cardiomyopathy. Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.. Related to restrictive ...
Constrictive pericarditis versus restrictive cardiomyopathy? J Am Coll Cardiol. 2016;67:2061-76. CrossRefPubMed ... Constrictive pericarditis and restrictive cardiomyopathy: evaluation with MR imaging. Radiology. 1992;182:369-73. CrossRef ... Restrictive cardiomyopathy. Delayed occurrence after radiotherapy of breast cancer Autoren:. MD Barbara Bellmann Brunilda ... Heart transplantation outcomes in radiation-induced restrictive cardiomyopathy. J Card Fail. 2016;22:475-8. CrossRefPubMed ...
Nonstandard abbreviations used: restrictive cardiomyopathy (RCM); troponin I gene (TNNI3); hypertrophic cardiomyopathy (HCM); ... Familial restrictive cardiomyopathy with atrioventricular block and skeletal myopathy. Br. Heart J. 1990. 63:114-118. View this ... Kushwaha, SS, Fallon, JT, Fuster, V. Restrictive cardiomyopathy. N. Engl. J. Med. 1997. 336:267-276. View this article via: ... Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations. Jens Mogensen,1 Toru ...
Causes of Restrictive Cardiomyopathy Restrictive cardiomyopathy is a rare condition that is sometimes attributed to ... Restrictive Cardiomyopathy Restrictive cardiomyopathy refers to a weakened heart muscle that struggles to function properly. ... Restrictive Cardiomyopathy. Restrictive cardiomyopathy refers to a weakened heart muscle that struggles to function properly. ... the exact cause of restrictive cardiomyopathy is unknown.. Some of the most common causes of restrictive cardiomyopathy include ...
A. Management of restrictive cardiomyopathy.. The most important step in treating restrictive cardiomyopathy involves ... but not restrictive cardiomyopathy. Second, any underlying process causing the restrictive cardiomyopathy should be determined ... echocardiography is a key test in diagnosing restrictive cardiomyopathy. Findings consistent with a restrictive cardiomyopathy ... Patients with restrictive cardiomyopathy will often have atrial enlargement, and this can be reflected on EKG with increased P ...
The pediatric heart experts at the Nemours Cardiac Center diagnose and treat restrictive cardiomyopathy (RCM) at Nemours/Alfred ... Restrictive cardiomyopathy (RCM) in children is a disease of the cardiac muscle in which the muscle (or "myocardium") cant ... Children with restrictive cardiomyopathy will need frequent echocardiograms and physician visits to monitor the changes in ... If your child has restrictive cardiomyopathy, know that at the Nemours Cardiac Center were here to give your child the very ...
Objective Restrictive cardiomyopathy (RCM) is among the five major cardio- myopathies. The purpose of this study was to ... Organic cardiovascular disease (myocarditis, cardiomyopathy, congenital heart disease, rheumatic heart disease,valve) ...
... restrictive cardiomyopathy - Answer: Sindee, I have found that green tea extract helps me but I also monitor ... ... Just was told I have restrictive cardiomyopathy anyone have this ? Did you have a transplant? How?. Asked. 14 Apr 2016 by ... Alcoholic Cardiomyopathy - My fiance was diagnosed with noneschemic cardiomyopathy in may.?. Posted 25 Jul 2015 • 1 answer ... Cardiomyopathy - I was told last month that I have cardiomyopothy, I am scared altho I try not to?. Posted 20 Mar 2010 • 1 ...
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