A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.
A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.
An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.
Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.
Contractile activity of the MYOCARDIUM.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
The hollow, muscular organ that maintains the circulation of the blood.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Myosin type II isoforms found in cardiac muscle.
The period shortly before, during, and immediately after giving birth.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
The innermost layer of the heart, comprised of endothelial cells.
Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.
The transference of a heart from one human or animal to another.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
A CALCIUM-dependent adhesion molecule of DESMOSOMES that also plays a role in embryonic STEM CELL proliferation.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Period of contraction of the HEART, especially of the HEART VENTRICLES.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A condition in which HEART VENTRICLES exhibit impaired function.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
The valve between the left atrium and left ventricle of the heart.
Examinations used to diagnose and treat heart conditions.
Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.
Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Elements of limited time intervals, contributing to particular results or situations.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.
A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.
A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.
The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .
The mitochondria of the myocardium.
A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.
Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The circulation of blood through the CORONARY VESSELS of the HEART.
AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.
Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.
A group of desmosomal cadherins with cytoplasmic tails that are divergent from those of classical CADHERINS. Their intracytoplasmic domains bind PLAKOGLOBIN; PLAKOPHILINS; and DESMOPLAKINS.
Biochemical identification of mutational changes in a nucleotide sequence.
A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.
A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
An individual having different alleles at one or more loci regarding a specific character.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.
The muscular structure separating the right and the left lower chambers (HEART VENTRICLES) of the heart. The ventricular septum consists of a very small membranous portion just beneath the AORTIC VALVE, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum.
The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)
Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
A group of muscle diseases associated with abnormal mitochondria function.
Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Activities or games, usually involving physical effort or skill. Reasons for engagement in sports include pleasure, competition, and/or financial reward.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.
A species of ENTEROVIRUS infecting humans and containing 36 serotypes. It is comprised of all the echoviruses and a few coxsackieviruses, including all of those previously named coxsackievirus B.
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
Rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist.
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Substances used to allow enhanced visualization of tissues.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.
Transport proteins that carry specific substances in the blood or across cell membranes.
Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
Radionuclide ventriculography where scintigraphic data is acquired during repeated cardiac cycles at specific times in the cycle, using an electrocardiographic synchronizer or gating device. Analysis of right ventricular function is difficult with this technique; that is best evaluated by first-pass ventriculography (VENTRICULOGRAPHY, FIRST-PASS).
Radiography of the heart and great vessels after injection of a contrast medium.
A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.
A strain of mice arising from a spontaneous MUTATION (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein DYSTROPHIN, have high serum levels of muscle ENZYMES, and possess histological lesions similar to human MUSCULAR DYSTROPHY. The histological features, linkage, and map position of mdx make these mice a worthy animal model of DUCHENNE MUSCULAR DYSTROPHY.
Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
The hemodynamic and electrophysiological action of the right HEART VENTRICLE.
The chambers of the heart, to which the BLOOD returns from the circulation.
A characteristic symptom complex.
An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An autosomal dominant disorder with an acronym of its seven features (LENTIGO; ELECTROCARDIOGRAM abnormalities; ocular HYPERTELORISM; PULMONARY STENOSIS; abnormal genitalia; retardation of growth; and DEAFNESS or SENSORINEURAL HEARING LOSS). This syndrome is caused by mutations of PTPN11 gene encoding the non-receptor PROTEIN TYROSINE PHOSPHATASE, type 11, and is an allelic to NOONAN SYNDROME. Features of LEOPARD syndrome overlap with those of NEUROFIBROMATOSIS 1 which is caused by mutations in the NEUROFIBROMATOSIS 1 GENES.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A method of recording heart motion and internal structures by combining ultrasonic imaging with exercise testing (EXERCISE TEST) or pharmacologic stress.
A condition characterized by the thickening of ENDOCARDIUM due to proliferation of fibrous and elastic tissue, usually in the left ventricle leading to impaired cardiac function (CARDIOMYOPATHY, RESTRICTIVE). It is most commonly seen in young children and rarely in adults. It is often associated with congenital heart anomalies (HEART DEFECTS CONGENITAL;) INFECTION; or gene mutation. Defects in the tafazzin protein, encoded by TAZ gene, result in a form of autosomal dominant familial endocardial fibroelastosis.
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.
A family of RNA viruses that infect fungi and protozoa. There are three genera: TOTIVIRUS; GIARDIAVIRUS; and LEISHMANIAVIRUS.
A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.
Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity.
The measurement of an organ in volume, mass, or heaviness.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
A single-pass transmembrane glycoproteins that mediate CALCIUM-dependent CELL ADHESION and are core components of DESMOSOMES.
Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.

Cardiac sympathetic activity estimated by 123I-MIBG myocardial imaging in patients with dilated cardiomyopathy after beta-blocker or angiotensin-converting enzyme inhibitor therapy. (1/2423)

Impaired cardiac sympathetic activity can be evaluated by 123I-metaiodobenzylguanidine (MIBG) imaging. METHODS: We studied the significance of MIBG imaging for 24 patients (age 58+/-12 y) with dilated cardiomyopathy (DCM). We compared 12 patients (group A) treated with metoprolol (dose from 30-60 mg/d) with 12 patients treated with angiotensin-converting enzyme (ACE) inhibitors. Patients were studied before treatment, after 5 mo of treatment (only in group A) and after 1 y of treatment. Cardiac MIBG uptake was assessed as the heart-to-mediastinum activity ratio (H/M) and total defect score (TDS) from anterior planar and SPECT MIBG images, which were acquired in 4 h after tracer injection. New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF) calculated by echocardiography were also assessed. RESULTS: TDS decreased in both groups (in group A, from 30+/-7 through 23+/-9 to 18+/-10; P < 0.01, in group B, from 30+/-6 to 24+/-8; P < 0.01) and H/M was increased in both groups (in group A, from 1.87+/-0.31 through 2.03+/-0.28 to 2.14+/-0.29; P < 0.01, in group B, from 1.82+/-0.28 to 1.94+/-0.26; P < 0.05). But TDS and H/M were more improved in group A than in group B (P < 0.05). LVEF was significantly increased in only group A (from 38+/-6 through 43+/-8 to 49%+/-9%; P < 0.01). NYHA improved in both groups (in group A, from mean 2.5 through 2.1 to 1.8; P < 0.01, in group B, from mean 2.6 to 2.1; P < 0.05) but was more improved in group A than in group B (P < 0.05). CONCLUSION: Cardiac function, symptom and cardiac sympathetic activity evaluated by MIBG images improved after the beta-blocker therapy more than with the treatment that used ACE inhibitors.  (+info)

Sympathetic nerve alterations assessed with 123I-MIBG in the failing human heart. (2/2423)

Norepinephrine (NE) reuptake function is impaired in heart failure and this may participate in myocyte hyperstimulation by the neurotransmitter. This alteration can be assessed by 123I-metaiodobenzylguanidine (MIBG) scintigraphy. METHODS: To determine whether the impairment of neuronal NE reuptake was reversible after metoprolol therapy, we studied 18 patients (43+/-7 y) with idiopathic dilated cardiomyopathy who were stabilized at least for 3 mo with captopril and diuretics. Patients underwent, before and after 6 mo of therapy with metoprolol, measurements of radionuclide left ventricular ejection fraction (LVEF), maximal oxygen consumption and plasma NE concentration. The cardiac adrenergic innervation function was scintigraphically assessed with MIBG uptake and release measurements on the planar images obtained 20 min and 4 h after tracer injection. To evaluate whether metoprolol had a direct interaction with cardiac MIBG uptake and release, six normal subjects were studied before and after a 1-mo metoprolol intake. RESULTS: In controls, neither cardiac MIBG uptake and release nor circulating NE concentration changed after the 1-mo metoprolol intake. Conversely, after a 6-mo therapy with metoprolol, patients showed increased cardiac MIBG uptake (129%+/-10% versus 138%+/-17%; P = 0.009), unchanged cardiac MIBG release and decreased plasma NE concentration (0.930+/-412 versus 0.721+/-0.370 ng/mL; P = 0.02). In parallel, patients showed improved New York Heart Association class (2.44+/-0.51 versus 2.05+/-0.23; P = 0.004) and increased LVEF (20%+/-8% versus 27%+/-8%; P = 0.0005), whereas maximal oxygen uptake remained unchanged. CONCLUSION: Thus, a parallel improvement of myocardial NE reuptake and of hemodynamics was observed after a 6-mo metoprolol therapy, suggesting that such agents may be beneficial in heart failure by directly protecting the myocardium against excessive NE stimulation.  (+info)

Regional patterns of myocardial sympathetic denervation in dilated cardiomyopathy: an analysis using carbon-11 hydroxyephedrine and positron emission tomography. (3/2423)

OBJECTIVE: To assess presynaptic function of cardiac autonomic innervation in patients with advanced congestive heart failure using positron emission tomography (PET) and the recently developed radiolabelled catecholamine analogue carbon-11 hydroxyephedrine (HED) as a marker for neuronal catecholamine uptake function. DESIGN AND PATIENTS: 29 patients suffering from dilated cardiomyopathy with moderate to severe heart failure were compared with eight healthy controls. Perfusion scan was followed by HED dynamic PET imaging of cardiac sympathetic innervation. The scintigraphic results were compared with markers of disease severity and the degree of sympathetic dysfunction assessed by means of heart rate variability. RESULTS: In contrast to nearly normal perfusions, mean (SD) HED retention in dilated cardiomyopathy patients was abnormal in 64 (32)% of the left ventricle. Absolute myocardial HED retention was 10.7 (1.0)%/min in controls v 6.2 (1.6)%/min in dilated cardiomyopathy patients (p < 0.001). Moreover, significant regional reduction of HED retention was demonstrated in apical and inferoapical segments. HED retention was significantly correlated with New York Heart Association functional class (r = -0.55, p = 0. 002) and ejection fraction (r = 0.63, p < 0.001), but not, however, with plasma noradrenaline concentrations as well as parameters of heart rate variability. CONCLUSIONS: In this study, using PET in combination with HED in patients with dilated cardiomyopathy, not only global reduction but also regional abnormalities of cardiac sympathetic tracer uptake were demonstrated. The degree of abnormality was positively correlated to markers of severity of heart failure. The pathogenetic mechanisms leading to the regional differences of neuronal damage as well as the prognostic significance of these findings remain to be defined.  (+info)

Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. (4/2423)

OBJECTIVE: To determine whether increased plasma concentrations of endothelin-1 (ET-1) and big endothelin (BET) play a role in the regulation of coronary circulation in patients with idiopathic dilated cardiomyopathy (IDCM). SETTING: Tertiary referral centre for cardiac diseases. PATIENTS: Fourteen patients (eight male/six female; mean (SD) age 59 (9) years) with IDCM (ejection fraction 36 (9)%) and five normotensive subjects (two male/three female; age 52 (7) years) serving as controls were studied. METHODS: Functional status was classified according to New York Heart Association (NYHA) class. Endogenous ET-1 and BET plasma concentrations from the aorta and the coronary sinus were determined by radioimmunoassay. Coronary blood flow, using the inert chromatographic argon method, myocardial oxygen consumption, and coronary sinus oxygen content under basal conditions were determined. RESULTS: In the aorta, mean (SD) concentrations of ET-1 (IDCM 0.76 (0.25) v controls 0.31 (0.06) fmol/ml; p = 0.002) and BET (IDCM 3.58 (1.06) v controls 2.11 (0.58) fmol/ml; p = 0.014) were increased in patients with IDCM. Aortic ET-1 concentrations correlated positively with NYHA class (r = 0. 731; p < 0.001), myocardial oxygen consumption (r = 0.749; p < 0. 001), and coronary blood flow (r = 0.645; p = 0.003), but inversely with coronary sinus oxygen content (r = -0.633; p = 0.004), which was significantly decreased in IDCM patients (IDCM 4.68 (1.05) v controls 6.70 (1.06) vol%; p = 0.003). CONCLUSIONS: The coronary circulation in patients with IDCM is exposed to an increased endothelin load. ET-1 concentrations correlate with functional deterioration. A decrease of the coronary sinus content of oxygen suggests a mismatch between coronary blood flow and metabolic demand. Thus, ET-1 might be a marker of a disequilibrium between myocardial oxygen demand and coronary blood flow in IDCM.  (+info)

Familial dilated cardiomyopathy locus maps to chromosome 2q31. (5/2423)

BACKGROUND: Inherited gene defects are an important cause of dilated cardiomyopathy. Although the chromosome locations of some defects and 1 disease gene (actin) have been identified, the genetic etiologies of most cases of familial dilated cardiomyopathy remain unknown. METHODS AND RESULTS: We clinically evaluated 3 generations of a kindred with autosomal dominant transmission of dilated cardiomyopathy. Nine surviving and affected individuals had early-onset disease (ventricular chamber dilation during the teenage years and congestive heart failure during the third decade of life). The disease was nonpenetrant in 2 obligate carriers. To identify the causal gene defect, linkage studies were performed. A new dilated cardiomyopathy locus was identified on chromosome 2 between loci GCG and D2S72 (maximum logarithm of odds [LOD] score=4.86 at theta=0). Because the massive gene encoding titin, a cytoskeletal muscle protein, resides in this disease interval, sequences encoding 900 amino acid residues of the cardiac-specific (N2-B) domain were analyzed. Five sequence variants were identified, but none segregated with disease in this family. CONCLUSIONS: A dilated cardiomyopathy locus (designated CMD1G) is located on chromosome 2q31 and causes early-onset congestive heart failure. Although titin remains an intriguing candidate gene for this disorder, a disease-causing mutation is not present in its cardiac-specific N2-B domain.  (+info)

From myocarditis to cardiomyopathy: mechanisms of inflammation and cell death: learning from the past for the future. (6/2423)

A progression from viral myocarditis to dilated cardiomyopathy has long been hypothesized, but the actual extent of this progression has been uncertain. However, a causal link between viral myocarditis and dilated cardiomyopathy has become more evident than before with the tremendous developments in the molecular analyses of autopsy and endomyocardial biopsy specimens, new techniques of viral gene amplification, and modern immunology. The persistence of viral RNA in the myocardium beyond 90 days after inoculation, confirmed by the method of polymerase chain reaction, has given us new insights into the pathogenesis of dilated cardiomyopathy. Moreover, new knowledge of T-cell-mediated immune responses in murine viral myocarditis has contributed a great deal to the understanding of the mechanisms of ongoing disease processes. Apoptotic cell death may provide the third concept to explain the pathogenesis of dilated cardiomyopathy, in addition to persistent viral RNA in the heart tissue and an immune system-mediated mechanism. Beneficial effects of alpha1-adrenergic blocking agents, carteolol, verapamil, and ACE inhibitors have been shown clinically and experimentally in the treatment of viral myocarditis and dilated cardiomyopathy. Antiviral agents should be more extensively investigated for clinical use. The rather discouraging results obtained to date with immunosuppressive agents in the treatment of viral myocarditis indicated the importance of sparing neutralizing antibody production, which may be controlled by B cells, and raised the possibility of promising developments in immunomodulating therapy.  (+info)

Echo derived variables predicting exercise tolerance in patients with dilated and poorly functioning left ventricle. (7/2423)

OBJECTIVE: To determine whether resting echo derived measurements predict exercise tolerance and its interrelation with heart rate response and ventilation drive in patients with systolic left ventricular disease. DESIGN: Prospective echocardiographic examination followed by cardiopulmonary exercise testing. SETTING: A tertiary referral centre for cardiac diseases. SUBJECTS: 21 patients (11 with coronary artery disease, 10 with idiopathic dilated cardiomyopathy) with end diastolic dimension > 6.4 cm, shortening fraction < 25%, and in sinus rhythm. There were 11 age matched normal controls. RESULTS: In the patients, peak oxygen consumption (mVo2) correlated with right ventricular long axis excursion (r = 0.62); 65% of the variance in mVo2 was predictable using a multivariate model with right ventricular long axis excursion and peak lengthening rate, and peak mitral atrial filling velocity as independent variables. Aetiology was not an independent predictor, although the right ventricular long axis excursion (mean (SD)) was greater in patients with idiopathic dilated cardiomyopathy than in those with coronary artery disease (2.4 (0.5) cm v 1.6 (0.5) cm, p < 0.001). Peak heart rate correlated with duration of mitral regurgitation (r = -0.52) and the slope of ventilation against CO2 production correlated with M mode isovolumic relaxation time (r = 0.61). CONCLUSIONS: In patients with systolic left ventricular dysfunction, more than half the variance in exercise tolerance can be predicted by factors measured on echocardiography at rest, particularly right ventricular long axis excursion.  (+info)

Effects of dilated cardiomyopathy on the diaphragm in the Syrian hamster. (8/2423)

This study aimed to elucidate changes in respiratory muscles and their mechanism in cardiomyopathy. The contractile properties and histology of the diaphragm, as well as serum levels of insulin-like growth factor (IGF)-1, were examined in 10 hamsters with idiopathic dilated cardiomyopathy (CM) and 10 controls. At 28 weeks, body weight in CM was reduced compared with controls (114+/-10 versus 144+/-14 g, p<0.0001). The ratio of diaphragm to body weight was significantly higher in CM than in controls (0.228+/-0.015 versus 0.182+/-0.017, p<0.0001). In vitro, maximal diaphragmatic twitch (303+/-63 versus 455+/-119 g x cm(-2)) and tetanic tensions (1,555+/-369 versus 2,204+/-506 g x cm(-2)) were significantly lower in CM than in controls (p<0.005). The half-relaxation time was significantly shorter in CM (19+/-1 ms) than in controls (24+/-3 ms, p<0.0005). Fatiguability at 25 Hz was significantly less in CM (28%) than in controls (42%, p<0.0001). Diaphragm and gastrocnemius adenosine triphosphatase staining showed type I fibre atrophy in CM, associated with an increase in the number of type I fibres in the diaphragm. Histological examination of both muscles revealed an abnormal muscular pattern. Finally, serum levels of IGF-1 were 47% lower in the CM group than in controls (p<0.0001) and were clearly related to the changes in the contractile properties and histology of the diaphragm. In conclusion, cardiomyopathy in hamsters: 1) depressed the force-generating capacity and shortened the relaxation of the hamster diaphragm; 2) induced type I fibre atrophy in combination with a myopathic pattern; and 3) was associated with a significant reduction in serum levels of insulin-like growth factor-1, related to the diaphragmatic changes. Whether these changes are primary myopathic or secondary to heart failure remains to be elucidated.  (+info)

We acknowledge and thank Dr Fukamachi and colleagues for their comments regarding our report describing the immediate effects of partial left ventriculectomy (PLV) on cardiac performance in a group of 8 patients with severe heart failure.R1 This study used pressure-area relations by echocardiographic automated border detection as a surrogate for pressure-volume relations to assess ventricular function in a predominately load-independent manner. Estimates of end-systolic elastance (Ees) and preload recruitable stroke work demonstrated variable immediate results of PLV. Changes in Ees and preload recruitable stroke work were inversely correlated with semiquantitative histological measures of myocardial fibrosis and directly related to degrees of hypertrophy.. Although Fukamachi et al raise some interesting points regarding the analysis of Ees from our data, they did not account for the fact that we used cross-sectional area as a surrogate for ventricular volume to estimate ventricular performance. ...
Surgical therapy for heart failure: care of the patient with partial left ventriculectomy. When to transplant: recipient selection for heart transplantation
Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM (familial DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of familial DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an idiopathic DCM. Current hypotheses regarding causes of idiopathic DCM focus on myocarditis induced by enterovirus and subsequent autoimmune myocardium impairments. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with idiopathic DCM, may increase the concentration of intracellular cAMP and ...
301 Semiquantitative histomorphometric analysis of myocardium following partial left ventriculectomy: one-year follow-up. Vasiljevic, J.D.; Otasevic, P.; Popovic, Z.B.; Neskovic, A.N.; Popovic, Z.V.; Vidakovic, R.V.; Radovancevic, B.; Frazier, O.Howard; Gradinac, S. // European Journal of Heart Failure. Supplements;Jun2004, Vol. 3 Issue 1, p73 An abstract of the article Semiquantitative histomorphometric analysis of myocardium following partial left ventriculectomy: one-year follow-up, by J. D. Vasiljevic et al., is presented. ...
Dilated cardiomyopathy (DCM) is a general diagnosis provided for a heart that is enlarged with decreased pumping function/contractility (i.e. systolic dysfunction). There are several etiologies that can result in DCM. The most common cause is a primary heart muscle disease called idiopathic dilated cardiomyopathy. Idiopathic DCM is thought to be genetic in many cases based on human studies and the prevalence of the disease in certain dog breeds (Doberman Pinschers, Irish Wolfhounds, Great Danes, Golden Retrievers, etc.). Other causes of DCM include an abnormally rapid arrhythmia (tachycardia-induced cardiomyopathy; TICM), nutritional/dietary deficiency (ex: taurine, L-carnitine, BEG diets), hypothyroidism (low thyroid level), infection/inflammation of the heart muscle (called myocarditis), degeneration of the mitral valve in large breed dogs, and some toxins/drugs.. As the heart dilates and loses its ability to contract appropriately, blood begins to pool within the left side of the heart ...
NTUSI, Ntobeko B A et al. Frequency and clinical genetics of familial dilated cardiomyopathy in Cape Town: implications for the evaluation of patients with unexplained cardiomyopathy. SAMJ, S. Afr. med. j. [online]. 2011, vol.101, n.6, pp.394-398. ISSN 2078-5135.. BACKGROUND: Studies from Europe and North America suggest that 20 - 50% of patients with dilated cardiomyopathy (DCM) may have familial disease. There is little information on the frequency and clinical genetics of familial DCM in Africa. PURPOSE: To determine the frequency and probable mode of inheritance of familial DCM in patients referred for investigation of the cause of DCM at a tertiary centre in Cape Town. METHODS: We conducted a retrospective analysis of consecutive patients diagnosed with DCM between 1 February 1996 and 31 December 2009 to determine the frequency of familial disease. RESULTS: Of 109 unrelated patients with DCM, 29 (26.6%) had familial disease. Their mean age of onset of cardiomyopathy (28.01 (standard ...
Heart problems are very important in people with Human Immunodeficiency Virus (HIV) as Acquired ImmunoDeficiency Syndrome (AIDS) patients with left ventricular dysfunction have a median survival of 101 days as compared to 472 days in AIDS patients with healthy hearts. HIV is a major cause of cardiomyopathy (problems with the heart muscle that reduce the efficiency with which the heart pumps blood). The most common type of HIV induced cardiomyopathy is dilated cardiomyopathy also known as eccentric ventricular hypertrophy which leads to impaired contraction of the ventricles due to volume overload. The annual incidence of HIV associated dilated cardiomyopathy was 15.9/1000 before the introduction of highly active antiretroviral therapy (HAART). However, in 2014, a study found that 17.6% of HIV patients have dilated cardiomyopathy (176/1000) meaning the incidence has greatly increased. Dilated cardiomyopathy can be due to pericardial effusion or infective endocarditis, especially in intravenous ...
TY - JOUR AU - Mestroni, L AU - Milašin, Jelena AU - Vatta, M AU - Pinamonti, B AU - Sinagra, G AU - Rocco, C AU - Matulić, M AU - Falaschi, A AU - Giacca, M. AU - Camerini, F PY - 1996 UR - http://smile.stomf.bg.ac.rs/handle/123456789/1070 AB - Recent studies have demonstrated that genetic factors are likely to play a major role in the pathogenesis of idiopathic dilated cardiomyopathy (IDC), In clinical surveys, a familial trait has been demonstrated in 20 to 30% of idiopathic dilated cardiomyopathy patients (familial dilated cardiomyopathy), Molecular genetic studies have confirmed the clinical hypothesis of genetic heterogeneity in familial dilated cardiomyopathy, and are currently producing relevant advances in the understanding of this disease, The autosomal dominant form is considered to be the most frequent form of inherited idiopathic dilated cardiomyopathy. After the exclusion of a large series of candidate genes, the first familial dilated cardiomyopathy gene has been mapped to the ...
Hypertrophic cardiomyopathy usually affects cats. The overall cardiac dysfunction associated with hypertrophic cardiomyopathy relates to a decrease in diastolic function. Anesthetic regimens that minimize increases in heart rate and stress-related catecholamine release are desirable. Patients with dilative cardiomyopathy can present asymptomatic or in congestive heart failure. The overall myocardial defect is a depression of systolic function. An anesthetic regimen that minimizes myocardial depression is essential.
The term cardiomyopathy is used to indicate myocardial dysfunction in the absence of an obstructive lesion or sustained hypertension. Cardiomyopathy can occur either in isolation or as a manifestation of a multisystem disease. Neonates who have an unrecognized cardiomyopathy may come to medical attention with a life-threatening decompensation associated with an otherwise minor illness, such as a viral upper respiratory infection. Alternatively, evidence of cardiomyopathy may be noted on an echocardiogram performed for evaluation of an unrelated problem. Other conditions cause ventricular dysfunction but may not have a long-term impact on cardiac muscle function, such as myocarditis or anomalous origin of the left coronary artery from the pulmonary artery, and will be discussed at the end of the chapter. ...
Define primary cardiomyopathy. primary cardiomyopathy synonyms, primary cardiomyopathy pronunciation, primary cardiomyopathy translation, English dictionary definition of primary cardiomyopathy. n. pl. car·di·o·my·op·a·thies A disease or disorder of the heart muscle, especially of unknown or obscure cause. n pathol a disease of the heart muscle...
Dilated cardiomyopathy (DCM) represents the most common cardiomyopathy worldwide. The familial type, named idiopathic, account for 20-48% of all cases. An accumulating body of literature indicates that the pathophysiologic mechanism of genetic DCM may be much more complex than expected involving the finely tuned mechanism of protein homeostasis. Intracellular proteins aggregation seems to be at the base of the activation of the inflammasome bringing to the release of inflammatory cytokines, such as IL1ß, IL 4 and IL 6 and may be involved in the clinical deterioration of patients affected by idiopathic DCM. For this purpose the cytokine levels of surgical patients affected by idiopathic terminal DCM were compared with healthy controls to assess the hypothesis that pro inflammatory status plays a role on the natural history of the DCM and to see if the VAD insertion was related to a reduction of the inflammasome activation. 10 idiopathic DCM affected patients who underwent VAD insertion were ...
The results of the study, to identify new genes involved in childrens cardiomyopathy, were presented to the annual conference of the European Society of Human Genetics by Dr Johanna Herkert, a clinical geneticist at the University Medical Centre of Groningen, The Netherlands.. The researchers mapped all the genes of two families with children with unexplained cardiomyopathy. They then looked for mutations on a candidate gene in 60 unrelated children with cardiomyopathy. Their immediate family members were also genetically tested.. They found five children from three unrelated families with cardiomyopathy caused by mutations in ALPK3. The children with mutations from both parents had severe hypertrophic and/or dilated cardiomyopathy in utero, at birth, or in early childhood.. Deficiency of alpha-kinase 3 has previously been associated with hypertrophic and dilated cardiomyopathy in mice.. The researchers concluded that mutations from both parents in the newly identified gene ALPK3 gave rise to ...
cardiomyopathy - MedHelps cardiomyopathy Center for Information, Symptoms, Resources, Treatments and Tools for cardiomyopathy. Find cardiomyopathy information, treatments for cardiomyopathy and cardiomyopathy symptoms.
Purpose: To estimate the cost-effectiveness of diagnostic pathways for assessing patients with ischaemic cardiomyopathy to identify patients with viable myocardium with a view to revascularisation Method: A decision analytic model was developed to estimate the cost-effectiveness of diagnostic strategies for assessing patients with ischaemic cardiomyopathy. The different diagnostic pathways were applied to a hypothetical cohort of patients with ischaemic cardiomyopathy and the probability of successful identification of viable myocardium and non-viable myocardium was determined by the accuracy of the diagnostic pathway. It was assumed that patients diagnosed with viable myocardium would be managed promptly by revascularisation and that the patients diagnosed with non-viable myocardium would be on medical therapy. The model assigned each patient a risk of death and rehospitalisation depending upon whether they are truly viable and whether they had revascularisation or not. Each patient then ...
TY - JOUR. T1 - Prognostic value of cardiopulmonary exercise testing in Idiopathic Dilated Cardiomyopathy. AU - Sinagra, Gianfranco. AU - Iorio, Annamaria. AU - Merlo, Marco. AU - Cannatà, Antonio. AU - Stolfo, Davide. AU - Zambon, Elena. AU - Di Nora, Concetta. AU - Paolillo, Stefania. AU - Barbati, Giulia. AU - Berton, Emanuela. AU - Carriere, Cosimo. AU - Magrì, Damiano. AU - Cattadori, Gaia. AU - Confalonieri, Marco. AU - Di Lenarda, Andrea. AU - Agostoni, Piergiuseppe. PY - 2016/11/15. Y1 - 2016/11/15. N2 - Background Although cardiopulmonary exercise testing (CPET) is considered as an important tool in risk stratification of patients with heart failure (HF), prognostic data in the specific setting of Idiopathic Dilated Cardiomyopathy (iDCM) are still undetermined. The aim of the study was to test the prognostic value of CPET in a large cohort of iDCM patients. Methods and results We analyzed 381 iDCM patients who consecutively performed CPET. The study end-point was a composite of ...
Cardiovascular disease is a leading cause of death in both humans and dogs. Dilated cardiomyopathy (DCM) accounts for a large number of these cases, reported to be the third most common form of cardiac disease in humans and the second most common in dogs. In human studies of DCM there are more than 50 genetic loci associated with the disease. Despite canine DCM having similar disease progression to human DCM studies into the genetic basis of canine DCM lag far behind those of human DCM. In this review the aetiology, epidemiology, and clinical characteristics of canine DCM are examined, along with highlighting possible different subtypes of canine DCM and their potential relevance to human DCM. Finally the current position of genetic research into canine and human DCM, including the genetic loci, is identified and the reasons many studies may have failed to find a genetic association with canine DCM are reviewed.. ...
TY - JOUR. T1 - Surgical options for the management of ischemic cardiomyopathy. AU - Michler, Robert E.. PY - 2013/10. Y1 - 2013/10. N2 - Opinion statement: Novel surgical alternatives and the refinement of conventional surgical therapies for the treatment of ischemic cardiomyopathy are in constant evolution. Current approaches involve the determined application of the appropriateness criteria for CABG surgery, the extension of mitral valve repair to complex patients with ischemic cardiomyopathy, finding appropriate patients who might benefit from surgical ventricular reconstruction, and surgical attempts to regenerate lost or damaged myocardium with transplanted stem cells. The refinement of surgical techniques and the medical optimization of candidates for surgery remain a cornerstone of management for patients with complex heart disease like ischemic cardiomyopathy. The horizon is bright for patients suffering from this condition and concentrated research efforts by groups such as the ...
Join us this September in raising awareness of pediatric cardiomyopathy, the number one cause of sudden cardiac arrest and heart transplants in children. In every state, city and neighborhood there is most likely a child with cardiomyopathy - one diagnosed today and one to be diagnosed tomorrow. You can help us get the word out that heart disease isnt just about adults; it affects kids too. In three easy ways, you can increase awareness of pediatric cardiomyopathy throughout the month of September. You can view each weeks activities by clicking on the below links or view the complete awareness activity calendar by clicking here. ...
Ischemic Cardiomyopathy - Patients with end-stage heart failure secondary to either ischemic or idiopathic cardiomyopathy frequently demonstrate worsening..
Atrial cardiomyopathy is a frequently encountered but underappreciated clinical entity that is characterized by altered atrial size and function. Although traditionally considered a primary atrial disorder, atrial cardiomyopathy was recently redefined to include secondary atrial remodelling. This conceptual shift has implications for the scope of etiological factors and intervention strategies. Our aim was to evaluate the potential contribution of genetics to atrial cardiomyopathy. Although the genetics of atrial cardiomyopathy is relatively unexplored, extensive efforts have been made to identify the genetic underpinnings of atrial fibrillation, which is a common complication of atrial cardiomyopathy. Interestingly, in-silico and functional studies suggest that atrial fibrillation-associated genetic variants mainly act by generating a proarrhythmogenic atrial cardiomyopathic substrate. Investigating the genetic basis of primary defects in atrial structure and function, as well as the genetic ...
AIMS: Cardiac dysfunction is a severe complication of anthracycline-containing anticancer therapy. The outcome of anthracycline-induced cardiomyopathy (AICM) compared with other non-ischaemic causes of heart failure (HF), such as idiopathic dilated cardiomyopathy (IDCM), is unresolved. The aim of this study was to compare the survival of AICM patients with an IDCM cohort followed at our centre from 1990 to 2016. METHODS AND RESULTS: We included 67 patients (67% female, 50 ± 15 years) with AICM, defined as onset of otherwise unexplained left ventricular ejection fraction (LVEF) ≤50% following anthracycline therapy, and 488 IDCM patients (28% female, 55 ± 12 years ...
The present study clearly demonstrated that the production of ET-1 is markedly increased in the LV of Bio 14.6 cardiomyopathic hamsters at a stage of CHF. The chronic administration of an ETA antagonist, TA-0201, markedly improved the survival rate of cardiomyopathic hamsters. In addition, after 6 weeks of treatment, TA-0201 effectively prevented (1) the increase in LVEDP, RVEDP, and CVP; (2) the decrease in LV +dP/dt/Pmax and RV +dP/dt/Pmax; and (3) RV hypertrophy. These results suggest that chronic ET blockade improves the survival rate and ameliorates both LV and RV dysfunction in cardiomyopathic hamsters. Therefore, it is strongly suggested that endogenous ET-1 plays an important role in the deterioration of CHF due to cardiomyopathy in hamsters.. Cardiomyopathy, as well as myocardial infarction, is one of the major causes of CHF.19 It has been reported that plasma ET-1 level is increased in patients with cardiomyopathy.2 To date, however, the contribution of ET-1 in CHF caused by ...
Viral infections that infect the heart are a major cause of cardiomyopathy. In some instances, cardiomyopathy is a result of another disease or its treatment, such as complex congenital (present at birth) heart disease, nutritional deficiencies, uncontrollable, fast heart rhythms, or certain types of chemotherapy for cancer. Sometimes, cardiomyopathy can be linked to a genetic abnormality. Other times, the cause is unknown. Three types of cardiomyopathy typically affect adults.. ...
Cardiomyopathy refers to diseases of the heart muscle. These diseases have a variety of causes, symptoms, and treatments. In cardiomyopathy, the heart muscle becomes enlarged or abnormally thick or rigid. In rare cases, the muscle tissue in the heart is replaced with scar tissue. As cardiomyopathy progresses, the heart becomes weaker and less able to pump blood through the body. This can lead to heart failure, arrhythmias (abnormal heart rhythms), fluid buildup in the lungs or legs, and, more rarely, endocarditis (a bacterial infection of the lining of the heart). The weakening of the heart also can lead to other severe complications. The four main types of cardiomyopathy are: ...
BACKGROUND. In dilated cardiomyopathies (DCMs) changes in expression of protein-coding genes are associated with reverse remodeling, and these changes can be regulated by microRNAs (miRs). We tested the general hypothesis that dynamic changes in myocardial miR expression are predictive of β-blocker-associated reverse remodeling.. METHODS. Forty-three idiopathic DCM patients (mean left ventricular ejection fraction 0.24 ± 0.09) were treated with β-blockers. Serial ventriculography and endomyocardial biopsies were performed at baseline, and after 3 and 12 months of treatment. Changes in RT-PCR (candidate miRs) or array-measured miRs were compared based on the presence (R) or absence (NR) of a reverse-remodeling response, and a miR-mRNA-function pathway analysis (PA) was performed.. RESULTS. At 3 months, 2 candidate miRs were selectively changed in Rs, decreases in miR-208a-3p and miR-591. PA revealed changes in miR-mRNA interactions predictive of decreased apoptosis and myocardial cell death. ...
Viral infections that infect the heart are a major cause of cardiomyopathy. In some instances, cardiomyopathy is a result of another disease or its treatment, such as complex congenital (present at birth) heart disease, nutritional deficiencies, uncontrollable, fast heart rhythms, or certain types of chemotherapy for cancer. Sometimes, cardiomyopathy can be linked to a genetic abnormality. Other times, the cause is unknown. Three types of cardiomyopathy typically affect adults.. ...
During National Heart Month, adult heart disease takes center stage. Join us this February in telling America that heart disease affects kids too, often with worse outcomes. Pediatric cardiomyopathy is the number one cause of sudden cardiac arrest and heart transplants in children. In every state, city and neighborhood there is most likely a child with cardiomyopathy - one diagnosed today and one to be diagnosed tomorrow. Participate in our National Heart Month 50-State Challenge in five easy ways and put a heart on your state in honor of cardiomyopathy heart kids across America. ...
This is a multicentre European double-blind,randomized and controlled trial with 2 parallel groups (1 study medication, 1 placebo) in order to analyse the impact of ACE inhibitors (ACEi) in subjects who carry a mutation but have not yet developed DCM (dilated cardiomyopathy).. Objective of the trial: Study the impact of ACE inhibitors (ACEi) in subjects who carry a mutation (leading to a genetic form of heart failure) but have not yet developed DCM.. Context. Dilated Cardiomyopathy (DCM) is one of the leading causes of Heart Failure due to systolic dysfunction and at least 30% of DCM are of familial/genetic origin, usually with autosomal dominant inheritance, and underlying genes and mutations are increasingly identified. Familial Dilated Cardiomyopathy (fDCM) is characterized by age-related penetrance (or delayed-onset), that means that the cardiac expression of the disease (echocardiographic abnormalities) is usually absent for a long period and progressively appears with advanced age, usually ...
TY - JOUR. T1 - Familial Dilated Cardiomyopathy. AU - Coughlin, Steven Scott. AU - Woosley, Raymond L.. AU - Michels, Virginia. AU - Moll, Patricia. AU - Rodeheffer, Richard J.. PY - 1992/6/11. Y1 - 1992/6/11. N2 - To the Editor: The well-designed study by Michels et al. (Jan. 9 issue)1 provides further evidence that the percentage of patients with idiopathic dilated cardiomyopathy who have familial disease is higher than previously thought. It should be noted, however, that all but one of the index patients in this series of patients from the Mayo Clinic were white.1 Epidemiologic studies have suggested that blacks may be at increased risk for idiopathic dilated cardiomyopathy, although few genetic studies of this disease have been undertaken in multiracial populations.2 , 3 In a recent case-control study of idiopathic dilated cardiomyopathy in Baltimore, a roughly threefold…. AB - To the Editor: The well-designed study by Michels et al. (Jan. 9 issue)1 provides further evidence that the ...
Symptoms of Cardiomyopathy dilated 1W including 7 medical symptoms and signs of Cardiomyopathy dilated 1W, alternative diagnoses, misdiagnosis, and correct diagnosis for Cardiomyopathy dilated 1W signs or Cardiomyopathy dilated 1W symptoms.
Caring - We are devoted to supporting those affected by cardiomyopathy. Dedicated - We are committed to giving information, advice & support across the UK. Responsive - We reach out to anyone who needs us. Collaborative - We work with others to benefit those affected by cardiomyopathy. Expert - We provide up to date specialist knowledge about cardiomyopathy. Realistic - We are always honest and realistic about cardiomyopathy and the impact it can have. ...
Dilated or congestive cardiomyopathy is a condition in which the heart becomes weakened and enlarged and the pumping chambers contract poorly. Dilated cardiomyopathy is the most common form of cardiomyopathy. It occurs more frequently in men than in women, and most common between the ages of 20 and 60. The decreased heart function can affect the delivery of blood to the lungs, liver and other body systems.. ...
In this study of patients with recent-onset cardiomyopathy, patients with lower expression of the receptors that initiate the apoptosis pathway, Fas and TNFR1, had significantly more LV recovery during subsequent follow-up, with mean improvements in LVEF of more than 20 EF units at 6 and 12 months. In contrast, patients with the highest Fas and TNFR1 expression had minimal improvements of LVEF evident during the course of the study. This analysis suggests that activation of apoptotic pathways may limit myocardial recovery in this disorder, and that the levels of Fas and TNFR1 expression may be useful clinical predictors of the potential for subsequent LV recovery.. In the IMAC study of acute cardiomyopathy and myocarditis, biopsy status, hemodynamic assessment, and metabolic stress testing all failed to predict subsequent improvements in LVEF (12). In cardiomyopathy of recent onset, the percentage of patients with biopsy-proven myocarditis in published series is variable, with as few as 10% ...
Jackie has very kindly asked me to provide some of my early experiences of Dilated Cardiomyopathy mainly, I think, because I have been living with DCM for 18 years, have had 2 ordinary pacemakers, 4 biventricular pacemakers and I helped set up and run two Support Groups in different parts of the country. First off, for any newly diagnosed cardiomyopathy sufferers, there are two golden rules. Firstly, most people diagnosed with cardiomyopathy these days can expect to live a normal life span and secondly, no two cases are ever the same.. My first indications of something wrong were chest pains on exertion (cycling) then waking up in the middle of the night taking, a few deep breaths and going back to sleep. I took myself off to my GP. The next thing I knew I was in the cardiac department of my local hospital having my blood pressure taken, my height measured, my weight checked, a blood sample sent for analysis and having the first of several electrocardiagrams (ECGs) and an echocardiogram. And ...
The Childrens Cardiomyopathy Foundation (CCF) is a national, non-profit 501(c) (3) organization focused on pediatric cardiomyopathy, a chronic and potentially life-threatening heart disease. Consider
Let others know that September is about pediatric cardiomyopathy. Add a Facebook frame, change your social media images, and share facts about cardiomyopathy with your network. Right click on the below links to download. ...
Anxiety cause enlarged heart cardiomyopathy - Is it possible for prolonged anxiety to cause an enlarged heart and cardiomyopathy in children? Never. Cardiomyopathy is a condition that can be inherited or it can be produced by a virus or it can be caused by an inherited metabolic problem. It is a chronic disease that affects the heart muscle.
Have you or a loved one been diagnosed with cardiomyopathy?. Please know CHF member group Cardiomyopathy UK has a booklet called Living with Cardiomyopathy which can be ordered for free or downloaded in digital format.. There is also a booklet called Hearty that is aimed at children of 8 years and under, to explain what cardiomyopathy is and how the heart functions. This too, is free to download.. Further information:. http://www.cardiomyopathy.org/booklets/booklet-order-form. ...
Press Release issued Feb 14, 2018: Transparency Market Research in a recent publication says competition in the global dilated cardiomyopathy therapeutics market is expected to grow as prominent companies strive to develop effective drugs for the treatment of dilated cardiomyopathy. For example, in February 2017, Myokardia Inc., a biopharmaceutical company, announced first time administer of MYK-491 to a batch of healthy subjects. MYK-491 is a treatment for dilated cardiomyopathy which is in Phase 1.
Cardiomyopathys Heart Bleeps Campaign is centred around confronting the stereotypes of how people with heart conditions are meant to look like. These assumptions lead to people with cardiomyopathy facing challenges when it comes to employment, benefits and lifestyle as people assume there is nothing wrong.. The campaign is made up of 9 case studies of people with Cardiomyopathy who have experienced judgement in the past from people who judge there to be nothing wrong with them on first impressions.. We worked with Cardiomyopathy to help visualise the campaign on their site and social channels. Creating a series of illustrated animations and images for each of the 9 case studies and additional social assets to help promote the supporter stories on their social channels.. ...
have a diagnosis of cardiomyopathy and is now broadly offered by the NHS. Although some clinical decisions may take into account the result of the genetic testing, genetic testing may have no clinical value to the individual already diagnosed with cardiomyopathy; however, it is important for the family members and it can help to identify individuals who are at risk of developing cardiomyopathy.. Inherited cardiac conditions usually have a 50% chance of being passed on and they do not skip generations.. It is also a useful test for family members who are thinking of planning a family and ...
Cardiomyopathy is a term used to refer to a group of heart disease disorders that are related to the heart muscle. There are 4 specific types of...
Cardiomyopathy is a set of heart conditions. Treatment of cardiomyopathy includes treating the causes of the condition and treating the disorders brought on by cardiomyopathy.
Hemochromatosis-Related Cardiomyopathy (Haemochromatosis-Related Cardiomyopathy): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
A 17-year-old, 1-kg, colony-housed, male squirrel monkey (Saimiri sciureus) developed clinical signs of congestive heart failure. The monkey presented with lethargy, increased heart and respiratory rates, and mild abdominal distention. The clinical history, laboratory analysis, and radiographic findings were consistent with heart failure due to dilative cardiomyopathy. Gross and microscopic examination of the heart confirmed a dilative cardiomyopathy. This is the first report describing congestive heart failure caused by dilative cardiomyopathy in a squirrel monkey. Spontaneous dilative cardiomyopathy may be infrequently observed in the squirrel monkeys because they are not routinely housed in the research environment during their advancing years ...
Exome sequencing will be used as part of a tiered genetic analysis in a large cohort of up to 700 pediatric cardiomyopathy subjects with systolic (dilated cardiomyopathy) or diastolic (hypertrophic or restrictive cardiomyopathy) dysfunction. The biological parent(s) of enrolled participants will also be approached about participating and providing a blood sample for genetic testing. In addition to the parent(s), the participants siblings and other relatives may also be approached regarding enrollment, based on the pedigree and family history.. This study will significantly increase our understanding of pediatric cardiomyopathy by defining the prevalence of mutations in genes known to cause cardiomyopathy as well as identifying novel disease-causing genes in the pediatric population. Genetic association tests will identify variants that modify disease. Novel bioinformatics and systems biology applications for interpretation of exome level genetic information will contribute fundamental knowledge ...
Extrinsic Cardiomyopathy are a more common type of Cardiomyopathy. It is where the primary pathology is outside the myocardium. Meanwhile, intrinsic Cardiomyopathy is defined as weakness inside the muscle of the heart. There are three more specific types of Cardiomyopathy. These are Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy and Restrictive Cardiomyopathy. Dilated Cardiomyopathy is the most common form. This form can lead to enlargement of the heart, especially the left ventricle, and the pumping function decreases. Hypertrophic Cardiomyopathy is when the muscle thickens, which can get in the way of the blood flow and prevents the heart to pump properly. Restrictive Cardiomyopathy is the most rarest form of Cardiomyopathy. It is when the walls of the ventricles stiffens but not thickens and can resist the normal filling of blood in the heart ...
Peripartum cardiomyopathy (PPCM) and dilated cardiomyopathy (DCM) show similarities in clinical presentation. However, while DCM patients do not recover and slowly deteriorate further, PPCM patients show either a fast cardiac deterioration or complete recovery. The aim of this study was to assess if underlying cellular changes can explain the clinical ... read more similarities and differences in the two diseases. We therefore assessed sarcomeric protein expression, modification, titin isoform shift, and contractile behavior of cardiomyocytes in heart tissue of PPCM and DCM patients and compared these to non-failing controls. Heart samples from ischemic heart disease (ISHD) patients served as heart failure control samples. Passive force was only increased in PPCM samples compared to controls while PPCM, DCM and ISHD samples all showed increased myofilament Ca(2+)-sensitivity. Length-dependent activation was significantly impaired in PPCM compared to controls, while no impairment was observed in ...
TY - JOUR. T1 - Recovery of echocardiographic function in children with idiopathic dilated cardiomyopathy. T2 - Results from the pediatric cardiomyopathy registry. AU - Everitt, Melanie D.. AU - Sleeper, Lynn A.. AU - Lu, Minmin. AU - Canter, Charles E.. AU - Pahl, Elfriede. AU - Wilkinson, James D.. AU - Addonizio, Linda J.. AU - Towbin, Jeffrey A.. AU - Rossano, Joseph. AU - Singh, Rakesh K.. AU - Lamour, Jacqueline. AU - Webber, Steven A.. AU - Colan, Steven D.. AU - Margossian, Renee. AU - Kantor, Paul F.. AU - Jefferies, John L.. AU - Lipshultz, Steven E.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 2014/4/15. Y1 - 2014/4/15. N2 - Objectives This study sought to determine the incidence and predictors of recovery of normal echocardiographic function among children with idiopathic dilated cardiomyopathy (DCM). Background Most children with idiopathic DCM have poor outcomes; however, some improve. Methods We studied children ,18 years of age from the Pediatric ...
Ischemic cardiomyopathy is a type of cardiomyopathy caused by a narrowing of the coronary arteries which supply blood to the heart. Typically, patients with ischemic cardiomyopathy have a history of acute myocardial infarction, however, it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. This cardiomyopathy is one of the leading causes of sudden cardiac death. The adjective iscehemic means characteristic of, or accompanied by ischemia - local anaemia due to mechanical obstruction of the blood supply.[citation needed] Signs and symptoms of ischemic cardiomyopathy include sudden fatigue, shortness of breath, dizziness, and palpitations.[citation needed] Ischemic cardiomyopathy is the cause of more than 60% of all cases of systolic congestive heart failure in most countries of the world. A chest radiograph that demonstrates coronary artery calcification is a probable indication of ischemic cardiomyopathy. The following are causes of ...
TY - JOUR. T1 - Preventing pediatric cardiomyopathy. T2 - A 2015 outlook. AU - Kantor, Paul F.. AU - Kleinman, Jake A.. AU - Ryan, Thomas D.. AU - Wilmot, Ivan. AU - Zuckerman, Warren A.. AU - Addonizio, Linda J.. AU - Everitt, Melanie D.. AU - Jefferies, John L.. AU - Lee, Teresa M.. AU - Towbin, Jeffrey A.. AU - Wilkinson, James D.. AU - Lipshultz, Steven E. PY - 2016/3/3. Y1 - 2016/3/3. N2 - Cardiomyopathies in children encompass a broad range of diseases, both genetic and acquired, which manifest as a primary cardiac disorder or as a cardiomyopathy secondary to systemic disease. The burden of this group of disorders is substantial, and growing on a global scale. The availability of disease altering treatments is limited, and therefore a focused review on the prevention of cardiomyopathies is justified. In this review, we address the prevention of cardiomyopathy in children by dealing with the root causes of disease at a molecular, clinical and population level. Recent years have yielded ...
The Syrian cardiomyopathic hamster (BIO14.6), that develops both muscular dystrophy and progressive cardiomyopathy, is widely used as an animal model of autosomal recessive cardiomyopathy mimicking human hypertrophic cardiomyopathy, and five genes have been proposed as strong candidates for the cause of cardiomyopathy. We recently mapped the cardiomyopathy locus of the hamster to the centromeric region of chromosome 9qa2.1-b1 by construction of a genetic linkage map of the Syrian hamster. Thus, we analyzed the loci of the five candidate genes, α tropomyosin, cardiac troponin T, adhalin, calpain 3 and cardiac myosin binding protein-C, by the FISH method, and found that these genes were mapped on the distal portion of chromosome 12qa5 and 4pa2 and the proximal portion of chromosomes 9qb7, 1qc1.1 and 1qb3, respectively. These results provide strong evidence that the five candidate genes previously proposed are not related to the hamster cardiomyopathy.. ...
Hypertrophic cardiomyopathy occurs as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the beta cardiac myosin heavy chain (MHC) gene account for approximately half of all cases of familial hypertrophic cardiomyopathy, the molecular causes of sporadic hypertrophic cardiomyopathy are unknown. To determine whether beta cardiac MHC mutations are also associated with sporadic disease, we screened this gene in seven individuals with sporadic hypertrophic cardiomyopathy. Mutations in the beta cardiac MHC genes were identified in two probands with sporadic disease. In that their parents were neither clinically nor genetically affected, we conclude that mutations in each proband arose de novo. Transmission of the mutation and disease to an offspring occurred in one pedigree, predicting that these are germline mutations. The demonstration of hypertrophic cardiomyopathy arising within a pedigree coincident with the appearance of a ...
The Center for Pediatric Cardiomyopathy, Heart Failure and Transplantation at NewYork-Presbyterian/Morgan Stanley Childrens Hospital brings together the expertise of a wide range of pediatric heart specialists to care for your child. We have extensive experience taking care of children with complex congenital heart disease and severe heart disorders, such as cardiomyopathy and congestive heart failure.
Dilated cardiomyopathy is myocardial disease characterized by dilatation and impaired contraction of the left ventricle or both left and right ventricle. The majority of these cases are secondary to coronary artery disease, hypertension and valvular cardiomyopathy. Patients diagnosed with dilated cardiomyopathy are further clinically evaluated for evidence of familial history of the disease. Those families have shown to have genetic predisposition to dilated cardiomyopathy; thus, currently there is no available single genetic test that allows comprehensive testing of all causative genes. We report a Kuwaiti case of dilated cardiomyopathy that was diagnosed at young age. The patient clinical presentation pointed out to the fact that this was a familial disease. This case is the first reported in Kuwait clinically presented with familial dilated cardiomyopathy implying a genetic susceptibility factor to be further investigated within the at-risk family members. 23-year-old Arab ethnicity Kuwaiti male with
Childrens Minnesota explains pediatric cardiomyopathy treatment & care. Learn more about causes, symptoms & diagnosis of cardiomyopathy in children today.
Steve R. Ommen: The hypertrophic cardiomyopathy is a condition that has been under-diagnosed and overly feared throughout the world. In the United States alone, there are over a half a million people that have hypertrophic cardiomyopathy, many of whom are completely asymptomatic and unaware of their diagnosis. Some people can die suddenly. Sudden cardiac death occurs randomly without warning.. Hartzell V. Schaff: Over 2/3 of the patients will have obstruction. And the obstruction to the left ventricular outflow tract is an indication for operation in patients that have symptoms. So we know now that 2/3 of the patients with hypertrophic cardiomyopathy and obstruction are candidates for surgery.. Steve R. Ommen: Hypertrophic cardiomyopathy is the most common inherited cardiomyopathy or heart muscle disease. People are born with the genetics for it, but the hypertrophy doesnt appear to start developing until adolescence, growth spurts, or beyond. It is possible for infants to born with thick heart ...
Steve R. Ommen: The hypertrophic cardiomyopathy is a condition that has been under-diagnosed and overly feared throughout the world. In the United States alone, there are over a half a million people that have hypertrophic cardiomyopathy, many of whom are completely asymptomatic and unaware of their diagnosis. Some people can die suddenly. Sudden cardiac death occurs randomly without warning.. Hartzell V. Schaff: Over 2/3 of the patients will have obstruction. And the obstruction to the left ventricular outflow tract is an indication for operation in patients that have symptoms. So we know now that 2/3 of the patients with hypertrophic cardiomyopathy and obstruction are candidates for surgery.. Steve R. Ommen: Hypertrophic cardiomyopathy is the most common inherited cardiomyopathy or heart muscle disease. People are born with the genetics for it, but the hypertrophy doesnt appear to start developing until adolescence, growth spurts, or beyond. It is possible for infants to born with thick heart ...
TY - JOUR. T1 - Apical myectomy for patients with hypertrophic cardiomyopathy and advanced heart failure. AU - Nguyen, Anita. AU - Schaff, Hartzell V. AU - Nishimura, Rick A.. AU - Geske, Jeffrey B.. AU - Dearani, Joseph A.. AU - King, Katherine S.. AU - Ommen, Steve R.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objective: In patients with apical hypertrophic cardiomyopathy, extensive apical hypertrophy may reduce left ventricular end-diastolic volume and contribute to diastolic dysfunction, angina, and ventricular arrhythmias. Transapical myectomy to augment left ventricular cavity size can increase stroke volume and decrease left ventricular end-diastolic pressure. In this study, we describe early outcomes of patients with apical hypertrophic cardiomyopathy after transapical myectomy and compare survival with that of patients with hypertrophic cardiomyopathy listed for heart transplantation. Methods: Between September 1993 and March 2017, 113 symptomatic patients with apical hypertrophic ...
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At the Stony Brook Heart Failure and Cardiomyopathy Center, we recognize that excellent heart failure care involves putting you in control of your condition with the help of your dedicated heart failure team. For many patients, heart failure is a chronic condition that requires long-term, well-managed care with doctors and nurses specially trained to evaluate and treat even the most complex forms of heart failure.. What is Cardiomyopathy?. Cardiomyopathy is any disease of the heart muscle that impairs the ability of the heart to pump normally. Cardiomyopathy may result in heart failure, where the heart cant pump as much blood as the body needs.. What is Heart Failure?. Heart failure means that your heart is not pumping blood through the heart and around the body as well as it should. It does not mean that your heart has stopped or is about to stop. In a healthy heart, the strong muscular walls both squeeze and relax in order to pump blood throughout the body. Learn more about heart failure ...
TY - JOUR. T1 - Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin. AU - Maeda, Masato. AU - Holder, Emma. AU - Lowes, Brian. AU - Valent, Scott. AU - Bies, Roger D.. PY - 1997/1/1. Y1 - 1997/1/1. N2 - Background: The cytoskeleton plays an important role in maintaining cell structure and integrity. Defects in cytoskeletal proteins can cripple cell strength and may cause cardiomyopathy. We analyzed heart tissues from subjects with dilated cardiomyopathy for abnormalities in the cardiac cytoskeleton. Metavinculin, a cardiac isoform of the cytoskeletal protein vinculin, connects actin microfilaments to the intercalated disk and membrane costameres of the heart. Methods and Results: Metavinculin and vinculin transcripts and protein were analyzed by polymerase chain reaction (PCR) and Western blotting. Thirty three human heart specimens were studied, including 5 normal controls, 4 subjects with ischemic cardiomyopathy, 1 with X-linked cardiomyopathy, and 23 ...
Their study, Rare Variant Mutations in Pregnancy-Associated or Peripartum Cardiomyopathy, will be published in the May 25 edition of Circulation but appears today in the online version of the nations leading journal of cardiovascular medicine. The article provides clinicians critical information on managing women, as well as the families of the women, who are diagnosed with cardiomyopathy, or heart muscle disease, of unknown cause during or after pregnancy.. There are literally thousands of women who have had peripartum cardiomyopathy but have no idea what caused it, Hershberger said. Some have died, some have had heart transplants and some live with severe heart dysfunction. What we have shown is that in some cases it has a genetic cause. They need to know that because it has dramatic implications for screening their offspring, as well as their siblings and parents. With an early indication of dilated cardiomyopathy in their at-risk family members, we can start treatment to prevent advanced ...
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By Dr. David Gross. My mothers Maine Coon cat has cardiomyopathy. What is that?. Cardio obviously pertains to the heart, myo pertains to muscle and pathy signifies pathology or abnormality. Therefore, cardiomyopathy is pathology or abnormality of the heart muscle. We describe two kinds of cardiomyopathy; hypertrophic and dilated. Both types occur because of genetic mutations in one or more of the various proteins that comprise the heart muscle.. A study published in 1993 in the American Journal of Cardiology compared lesions found in 38 humans, 51 cats and 10 dogs that died of spontaneous hypertrophic cardiomyopathy. The authors of the paper discovered almost identical changes in all of the subjects.. Hypertrophic cardiomyopathy results in an increase in the volume of the heart muscle. As the muscle, usually that of the left ventricle, the chamber of the heart responsible for pumping blood out into the body, is forced to work harder it becomes thicker. As this happens the muscle also ...
Dilated cardiomyopathy (DCM), a primary disorder of the cardiac muscle characterized by ventricular chamber dilation and diminished cardiac contractility (1), is the most common cause of chronic heart failure (CHF) in the young and the most common indication for cardiac transplantation (2). The underlying etiologies are varied and include genetic, viral (myocarditis), toxins like alcohol, mitochondrial, and metabolic disorders (3-6).. Familial inheritance is seen in ≈30% to 40% of DCM patients (5). Autosomal dominant mode of inheritance is the most common (≈90%), followed by X-linked (5% to 10%), autosomal recessive, and mitochondrial inheritance patterns (,5%) (7). To date, mutations in ≈20 genes have been discovered in patients with DCM (8). Of these genes, the genes encoding Z-band alternatively spliced PDZ-motif protein, titin, lamin A/C, and β-myosin heavy chain may each be responsible for 5% to 10% of familial DCM cases (9-12), with dystrophin thought to contribute in 10% to 15% of ...
In some cases, cardiomyopathy is diagnosed when a heart murmur is detected at a routine doctor visit, although children with cardiomyopathy do not always have a heart murmur. Another way of diagnosing cardiomyopathy is through special genetic screening, which may be performed if a family member has the condition. Unfortunately, since cardiomyopathy is hard to detect, many children are not diagnosed until the disease has progressed to the point that they have signs of heart failure.. A number of tests may be used to aid the diagnosis of cardiomyopathy as well as to determine the type of the disease. These include:. ...
The report on the Global Cardiomyopathy Devices market offers complete data on the Cardiomyopathy Devices market. Components, for example, main players, analysis, size, situation of the business, SWOT analysis, and best patterns in the market are included in the report. In addition to this, the report sports numbers, tables, and charts that offer a clear viewpoint of the Cardiomyopathy Devices market. The top contenders Cleveland Clinic, Boston Scientific, Bionet, BTL Corporate, GE Healthcare, Innomed Medical, Roche, Aixin Medical Equipment, Mortara Instrument, Philips Healthcare, Schiller AG of the global Cardiomyopathy Devices market are further covered in the report .. Access to the sample pages of the report at: http://www.extentresearch.com/request-for-sample.html?repid=20376. The report also segments the global Cardiomyopathy Devices market based on product mode and segmentation Diagnosis Equipments, Treatment Devices. The study includes a profound summary of the key sectors and the ...
TY - JOUR. T1 - Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy. AU - Brauch, Katharine M.. AU - Karst, Margaret L.. AU - Herron, Kathleen J.. AU - de Andrade, Mariza. AU - Pellikka, Patricia A.. AU - Rodeheffer, Richard J.. AU - Michels, Virginia V.. AU - Olson, Timothy M.. PY - 2009/9/1. Y1 - 2009/9/1. N2 - Objectives: We sought to identify a novel gene for dilated cardiomyopathy (DCM). Background: DCM is a heritable, genetically heterogeneous disorder that remains idiopathic in the majority of patients. Familial cases provide an opportunity to discover unsuspected molecular bases of DCM, enabling pre-clinical risk detection. Methods: Two large families with autosomal-dominant DCM were studied. Genome-wide linkage analysis was used to identify a disease locus, followed by fine mapping and positional candidate gene sequencing. Mutation scanning was then performed in 278 unrelated subjects with idiopathic DCM, prospectively identified at the Mayo Clinic. ...
Cardiomyopathy refers to diseases of the heart muscle which cause the heart to become weaker. There are many different causes of cardiomyopathy. This study is looking at patients with cardiomyopathy that is not due to a reduced blood supply to the heart muscle. Reduced blood supply is called ischemic, so this study is looking at patients with non-ischemic cardiomyopathy (NICM). Ejection fraction (EF) is the amount of blood leaving the heart each time it contracts. EF is a measure of the strength, or how well the heart pumps with each beat and it is measured on tests such as echocardiogram (ultrasound) and cardiac magnetic resonance imaging (CMR). Patients newly diagnosed with NICM who have a reduced ejection fraction (EF) of less than or equal to 40% may be eligible for this study. Patients with NICM are at increased risk for hospitalizations due to congestive heart failure, abnormal heart rhythms and are also at an increased risk of sudden cardiac death. An implanted device, called an ...
TY - JOUR. T1 - A case of congenital hypertrophic cardiomyopathy. AU - Seo, Hyeon Seok. AU - Lee, In Hak. AU - Song, Young Wooh. AU - Choi, Byung Min. AU - Jang, Gi Young. AU - Son, Chang Sung. AU - Lee, Joo Won. PY - 2013/1. Y1 - 2013/1. N2 - Congenital hypertrophic cardiomyopathy (HCMP) is a very rare congenital heart disease. Here, we report a case of neonatal HCMP, which was confirmed by two-dimensional echocardiography and autopsy. The HCMP rapidly progressed and the patients condition deteriorated, despite the treatment for congestive heart failure.. AB - Congenital hypertrophic cardiomyopathy (HCMP) is a very rare congenital heart disease. Here, we report a case of neonatal HCMP, which was confirmed by two-dimensional echocardiography and autopsy. The HCMP rapidly progressed and the patients condition deteriorated, despite the treatment for congestive heart failure.. KW - Cardiomyopathy, hypertrophic. KW - Newborns. UR - ...
Obstructive hypertrophic cardiomyopathy (HCOM) is known as a familial genetic disorder. The most potent risk factor in the development of hypertrophic cardiomyopathy aregenetic mutations in Beta-myosin heavy chain, Myosin binding protein C, and Cardiac troponin T. Genes involved in the pathogenesis of hypertrophic cardiomyopathy include but not limited to MYH7, TNNT2, TPM1. However, hypertension, thyroid disease, diabetes, and obesity also play a role in non obstructive forms of hypertrophic cardiomyopathy. This is in response to chronic effects of abnormal pressure and volumes on the myocardium and is different from apical hypertrophy (Yamaguchi syndrome). ...
Although clinical studies indicate that patients with idiopathic dilated congestive cardiomyopathy who develop electrocardiographic or angiographic signs of left ventricular (LV) hypertrophy may survive longer, there is little morphologic evidence for such anatomic favorable of unfavorable prognostic groups. We studied 30 autopsied patients who died of dilated cardiomyopathy; of these, 15 died within 1 year of the first symptom of their disease (short-term survivors) and 15 patients died 1-14 years after initial symptoms (long-term survivors). There were no significant differences in sex, race, clinical presentation or cause of death between the groups, but there were significant morphologic differences. In the short-term survivors, average heart weight was 540 g and LV wall thickness was 1.0 cm, whereas in the long-term survivors, the average heart weight was 759 g and LV wall thickness was 1.3 cm (p less than 0.001). LV cavity dilatation as measured by maximal transverse diameter from the ...
Global Hypertrophic Cardiomyopathy Therapeutics Market - Key Trends With heart diseases emerging as one of the most common causes of mortality among men and women worldwide, Transparency Market Research (TMR) expects the demand for hypertrophic cardiomyopathy (HCM) therapeutics to surge considerably. Furthermore, the market is expected to gain significant impetus from successful government interventions aimed at spreading awareness about hypertrophic cardiomyopathy.. View Report-. https://www.transparencymarketresearch.com/hypertrophic-cardiomyopathy-therapeutics-market.html. TMR projects the global HCM therapeutics market to expand at a moderate 1.4% CAGR between 2015 and 2023. Despite witnessing positive opportunities, the rising demand for advanced medical devices could threaten the markets growth to an extent. Nevertheless, since the majority of HCM drugs are yet to get approved, the hypertrophic cardiomyopathy therapeutics market is likely to gain momentum post their approval in the near ...
Dilated cardiomyopathy (DCM) is a breed-specific, high prevalence disorder in Doberman Pinschers. However, the genetic background of DCM and its relationship to cardiac arrhythmias remains largely unknown. To uncover the genetic risk loci and variants that are associated with DCM, we have established a cohort of over 550 Dobermans with cardiological examination, which included echography, electrocardiogram and 24-hour Holter monitoring. The cohort was genotyped using Affymetrix Axiom 2.0 arrays with ~1.2 M SNPs, and 180 cases and 180 controls that met inclusion criteria were selected for analysis. About 290k informative SNPs remained for analysis after quality control. Genome wide association analysis was performed with single-locus and mixed model approaches and multiple testing was corrected by permutation or Bonferroni correction. A novel locus in chromosome 5 was revealed with genome wide significance (praw=1.376×10-11, pBonf=4.099×10-6). This new locus is different from the previously ...
Heart failure resulting from ischaemic heart disease is associated with a poor prognosis despite optimal medical treatment. Despite this, patients with ischaemic cardiomyopathy have been largely excluded from randomised trials of revascularisation in stable coronary artery disease. Revascularisation has multiple potential mechanisms of benefit, including the reversal of myocardial hibernation, suppression of ventricular arrhythmias and prevention of spontaneous myocardial infarction. Coronary artery bypass grafting is considered the first-line mode of revascularisation in these patients; however, evidence from the Surgical Treatment of Ischaemic Heart Failure (STICH) trial showed a reduction in mortality, though this only became apparent with extended follow-up due to an excess of early adverse events in the surgical arm. There is currently no randomised controlled trial evidence for percutaneous coronary intervention in patients with ischaemic cardiomyopathy; however, the REVIVED-BCIS2 trial ...
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Another heart problem in the breed is dilated cardiomyopathy, a condition in which the heart becomes weakened and enlarged and ... "Dilated Cardiomyopathy: Dogue de Bordeaux". Genetic welfare problems of companion animals. Universities Federation for Animal ...
Dystrophin abnormalities in X-linked dilated cardiomyopathy". Circulation. 95 (10): 2344-7. doi:10.1161/01.cir.95.10.2344. PMID ... and DMD-associated dilated cardiomyopathy. The mild end of the spectrum includes asymptomatic increases in serum creatine ...
Healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain. Subepicardial fibrosis ( ... Subepicardial fibrosis, which is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy. ... "Catheter Ablation of VT in Non-Ischaemic Cardiomyopathies: Endocardial, Epicardial and Intramural Approaches". Heart, Lung and ...
Healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain. Replacement fibrosis in ...
"Postrenal biopsy AVM leading to severe hypertension and dilated cardiomyopathy". Pediatr. Nephrol. 24 (12): 2459-62. doi: ... "Gregory M. Hirsch Hypertrophic Cardiomyopathy Center". Archived from the original on January 27, 2011. Retrieved November 9, ...
Hypertrophy of interventricular septum and left ventricle and dilated cardiomyopathy. Hypogonadism, kidney failure, urogenital ...
Micrograph of healthy myocardium versus interstitial fibrosis in dilated cardiomyopathy. Alcian blue stain. The fibrosis is ... and is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy. Replacement fibrosis, ... "Catheter Ablation of VT in Non-Ischaemic Cardiomyopathies: Endocardial, Epicardial and Intramural Approaches". Heart, Lung and ...
... a role in idiopathic dilated cardiomyopathy?". Journal of Molecular Medicine. 78 (2): 87-93. doi:10.1007/s001090000080. PMID ...
Cardiomyopathy, Dilated, 1f And Limb-Girdle Muscular Dystrophy Type 1d, Formerly. CMD1f And LGMD1d, Formerly. Cardiomyopathy, ... Arrhythmogenic Right Ventricular Cardiomyopathy 7, Formerly; ARVC7, Formerly. Inclusion Body Myopathy 1, Autosomal Dominant, ... Myofibrillar Myopathy With Arrhythmogenic Right Ventricular Cardiomyopathy. Desmin-Related Myopathy With Arrhythmogenic Right ... Dilated, with Conduction Defect and Muscular Dystrophy; CDCD3, formerly. Huizing, Marjan; Krasnewich, Donna M. (2009-09-01). " ...
The official cause of death was ruled accidental, citing dilated cardiomyopathy. Between April 2008 and June 2008, statements ... of drugs or a heart attack in Barrier's body A later autopsy report later stated that Barrier died of dilated cardiomyopathy ( ...
Wishard died in Indianapolis on July 11, 1917 from dilated cardiomyopathy. He was buried at Crown Hill Cemetery. Wishard's ...
In 2016, Maeda revealed that he is suffering from dilated cardiomyopathy. To recover from this condition, he will need a heart ...
"Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy". American Heart Journal. 122 (3 ...
Cardiomyopathy is one of the more severe manifestations of BTHS. The myocardium is dilated, reducing the systolic pump of the ... Though not always present, the cardinal characteristics of this multi-system disorder include: cardiomyopathy (dilated or ... November 1991). "X-linked dilated cardiomyopathy with neutropenia, growth retardation, and 3-methylglutaconic aciduria". The ... A majority of BTHS patients are hypotonic at birth, show signs of cardiomyopathy within the first few months of life, and ...
... patients often present with dilated cardiomyopathy. The ocular muscles are usually spared.[citation needed] The different genes ...
May 2001). "Partial left ventriculectomy for dilated cardiomyopathy: is this an alternative to transplantation?". J. Thorac. ... Chagas cardiomyopathy thus represents a unique method of study of diastolic heart failure. It may be addressed by removal of a ... heart procedure that proposed the reversal of the effects of remodeling in cases of end-stage dilated cardiomyopathy refractory ... by Brazilian physician and cardiac surgeon Randas Batista in 1994 for use in patients with non-ischemic dilated cardiomyopathy ...
... were responsible for dilated cardiomyopathy, especially after ischemia/reperfusion. It is still unclear as to whether opening ... "ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating". Nat. Genet. 36 (4): 382-7. ...
"Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies". Circulation. 121 (8): 997-1004. doi: ...
A postmortem exam revealed the cause of death to have been dilated cardiomyopathy. After her husband's sudden death, McElhone ...
Juvenile dilated cardiomyopathy is a fatal condition caused by an autosomal recessive gene. Affected puppies die suddenly or ... which will determine if a dog is a carrier of the gene for juvenile dilated cardiomyopathy. All breeding animals can be tested ... there is no known cure or treatment but there is a way to prevent producing puppies affected by juvenile dilated cardiomyopathy ...
If ventricular compliance increases (such as in dilated cardiomyopathy where the ventricle becomes highly dilated without ... In dilated cardiomyopathy, the ventricle becomes dilated without compensatory thickening of the wall. The LV is unable to pump ... Restrictive cardiomyopathy includes a group of heart disorders in which the walls of the ventricles become stiff (but not ... Cardiomyopathy and heart failure cause a reduction in cardiac output, whereas infection and sepsis are known to increase ...
... has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy". Circulation. 118 (12): 1250-8. doi:10.1161/ ...
However, on 14 August, she died due to Ischaemic dilated cardiomyopathy precipitated by pneumonia. On 20 August 2009 one new ...
Furthermore, mutations in SCN5A can cause Brugada syndrome, cardiac conduction disease, and dilated cardiomyopathy. In rare ...
"Percutaneous Mitral Annular Reduction Provides Continued Benefit in an Ovine Model of Dilated Cardiomyopathy". Circulation. 110 ...
Very frequent PVCs in people with dilated cardiomyopathy may be treated with radiofrequency ablation. Although there are many ... Some possible underlying causes of PVCs include: Adrenaline excess High blood calcium Cardiomyopathy, hypertrophic or dilated ... can develop dilated cardiomyopathy. In these cases, if the PVCs are reduced or removed (for example, via ablation therapy) the ... In general, PVCs are harmless, but frequent PVCs may increase the risk of developing arrhythmias or cardiomyopathy, which can ...
"Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy". Clin. Chim. Acta ...
Vinnie Paul died on June 22, 2018; his cause of death was later announced as dilated cardiomyopathy and coronary artery disease ...
Johns died on 1 August 2014, at the age of 35 of dilated cardiomyopathy. John Lee was born in Perth, Western Australia on 20 ... On 18 November 2014, the coroner reported that Johns had died of dilated cardiomyopathy, which inhibited the flow of blood to ...
... can help detect cardiomyopathies, such as hypertrophic cardiomyopathy, dilated cardiomyopathy, and many others ... Goland S, Czer LS, Luthringer D, Siegel RJ (January 2008). "A case of arrhythmogenic right ventricular cardiomyopathy". Can J ... This enables detailed anatomical assessment of cardiac pathology, particularly valvular defects, and cardiomyopathies. The ...
LMNA-Related Dilated Cardiomyopathy. 19 September 2013. PMID 20301717. NBK1674.. In GeneReviews *OMIM Cardiomyopathy, Dilated, ... dilated cardiomyopathy, Charcot-Marie-Tooth disease, Restrictive dermopathy and Hutchinson-Gilford progeria syndrome. A ...
... symptoms of the deficiency can present as dilated cardiomyopathy, congestive heart failure, and respiratory failure. The ...
"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase". Nature Genetics. 11 (4): ...
"Ubiquitin proteasome dysfunction in human hypertrophic and dilated cardiomyopathies". Circulation. 121 (8): 997-1004. doi: ...
"Tuberculous dilated cardiomyopathy: an under-recognized entity?". BMC Infect Dis. svezak 5 (broj 1): str. 29. PMC 1090580. PMID ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Tachycardia-induced. *Restrictive. *Loeffler endocarditis. *Cardiac ...
Agarwal, R., Malhotra, P., Awasthi, A., Kakkar, N., Gupta, D. Tuberculous dilated cardiomyopathy: an under-recognized entity?. ...
Cardiomyopathy: Dilated (Alcoholic), Hypertrophic, and Restrictive *Loeffler endocarditis. *Cardiac amyloidosis. *Endocardial ...
Familial AF presenting in the setting of another inherited cardiac disease (hypertrophic cardiomyopathy, dilated cardiomyopathy ... High blood pressure, valvular heart disease, coronary artery disease, cardiomyopathy, congenital heart disease, COPD, obesity, ... cardiomyopathy, and congenital heart disease.[5] In the developing world, valvular heart disease often occurs as a result of ... hypertrophic cardiomyopathy (HCM), pericarditis, congenital heart disease, and previous heart surgery.[24] Congenital heart ...
About two-thirds of people with chronic symptoms have cardiac damage, including dilated cardiomyopathy, which causes heart ... Autonomic disease imparted by Chagas may eventually result in megaesophagus, megacolon and accelerated dilated cardiomyopathy. ...
Agarwal R, Malhotra P, Awasthi A, Kakkar N, Gupta D (2005). "Tuberculous dilated cardiomyopathy: an under-recognized entity?". ...
Chest radiographs of cardiac resynchronization therapy with defibrillator (CRT-D) in an individual with dilated cardiomyopathy ... "Effective cardiac resynchronization therapy for an adolescent patient with dilated cardiomyopathy seven years after mitral ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Tachycardia-induced. *Restrictive. *Loeffler endocarditis. *Cardiac ...
This leads to diagonal double vision and a dilated pupil. The fourth (trochlear) and sixth (abducens) cranial nerves are ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis. *Endocardial ...
"Tuberculous dilated cardiomyopathy: an under-recognized entity?". BMC Infect Dis. 5 (1): 29. doi:10.1186/1471-2334-5-29. PMC ...
... dilated cardiomyopathy). ... and Cardiomyopathy - Evalve, Inc Archived June 8, 2007, at the ...
Myocarditis - Cardiomyopathy (Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Restrictive cardiomyopathy) - Arrhythmogenic ...
Dilated cardiomyopathy 1I. *GFAP: Alexander disease. *Peripherin: Amyotrophic lateral sclerosis. 4. *Neurofilament: Parkinson's ...
HIV is a major cause of cardiomyopathy - in particular dilated cardiomyopathy. Dilated cardiomyopathy can be due to pericardial ... of HIV patients have dilated cardiomyopathy (176/1000) meaning the incidence has greatly increased. Dilated cardiomyopathy can ... The most common type of HIV induced cardiomyopathy is dilated cardiomyopathy also known as eccentric ventricular hypertrophy ... Zidovudine is an example of a nucleoside analogue and has been shown to cause: myocarditis and dilated cardiomyopathy as well ...
I42) Cardiomyopathy *(I42.0) Dilated cardiomyopathy. *(I42.1) Obstructive hypertrophy cardiomyopathy. *(I42.2) Other ... I43) Cardiomyopathy in diseases classified elsewhere. Other[edit]. *(I50) Heart failure *(I50.0) Congestive heart failure * ...
1997). "Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin". Circulation 95 (1): 17-20 ...
സർ‌വ സാധാരണമായി കാണുന്ന രോഗങൾ ഡൈലേറ്റഡ് കാർഡിയോമയോപ്പതി(dilated cardiomyopathy)[8],വോബ്ലർ രോഗം (wobbler disease)[9], വോൺ വിൽ ...
"Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin- ...
ताकोसुबो कार्दियोमायोप्याथी (Transient apical ballooning, stress-induced cardiomyopathy) A type of dilated cardiomyopathy ... A type of dilated cardiomyopathy caused by chronic tachycardia.. ... Cardiomyopathy caused by excessive rigidity of the heart.. ... एरिद्मोजेनिक राइत भेन्त्रिकुलर दिस्प्लेसिया (Arrhythmogenic right ventricular cardiomyopathy) Cardiomyopathy caused by a ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis. *Endocardial ...
Other effects of a diet lacking in this essential amino acid are dilated cardiomyopathy and reproductive failure in females.[55 ... Decreased plasma taurine concentration has been demonstrated to be associated with feline dilated cardiomyopathy.[58] Unlike ... a reversible cardiomyopathy". Science. 237 (4816): 764-8. Bibcode:1987Sci...237..764P. doi:10.1126/science.3616607. PMID ...
Photographing the back of the dilated eye allows the confirmation of bone spicule accumulation in the fundus, which presents ...
Myocarditis - Cardiomyopathy (Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Restrictive cardiomyopathy) - Arrhythmogenic ...
Echocardiography can help detect cardiomyopathies, such as hypertrophic cardiomyopathy, dilated cardiomyopathy, and many others ... Heart disease, Cardiovascular disease, Atherosclerosis, Cardiomyopathy, Hypertension (High Blood Pressure). Significant tests. ... Cardiac disorders such as coronary heart disease, including myocardial infarction, heart failure, cardiomyopathy, and ... Wallace Brigden (1916-2008), identified cardiomyopathy. *Willem Einthoven (1860-1927), a physiologist who built the first ...
dilated cardiomyopathy Dilated or congestive cardiomyopathy is a condition in which the heart becomes weakened and enlarged and ... Dilated cardiomyopathy is the most common form of cardiomyopathy. It occurs more frequently in men than in women, and most ...
... in intravascular volume and cardiac output during pregnancy is poorly tolerated by patients with primary dilated cardiomyopathy ... Primary dilated cardiomyopathy is rare in women of childbearing age. The expected increase ... BACKGROUND: Primary dilated cardiomyopathy is rare in women of childbearing age. The expected increase in intravascular volume ... Cardiomyopathy, Dilated / physiopathology*. Female. Humans. Pregnancy. Pregnancy Complications, Cardiovascular / ...
The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med. ... Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science. 1998; 280: 750-752. ... Deletion of the dystrophin muscle-promoter region associated with x-linked dilated cardiomyopathy. N Engl J Med. 1993; 329: 921 ... Dilated cardiomyopathy associated with deficiency of the cytoskeletal protein metavinculin. Circulation. 1997; 95: 17-20. ...
Dilated CardiomyopathyDilated cardiomyopathy is a term used to describe a condition of the heart in which one or more of the ... Dilated cardiomyopathy is a term used to describe a condition of the heart in which one or more of the chambers of the heart ... In dilated cardiomyopathy the heart fails to pump adequately. This can result in symptoms such as breathlessness, weakness and ... Hypertrophic cardiomyopathy is a…. *. ICD DeviceAn Implantable Cardioverter Defibrillator, or ICD, is a battery-powered device ...
Genetics Home Reference related topics: X-linked dilated cardiomyopathy Familial dilated cardiomyopathy ... Cardiomyopathies. Cardiomyopathy, Dilated. Heart Diseases. Cardiovascular Diseases. Cardiomegaly. Coenzyme Q10. Ubiquinone. ... Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy. The safety and scientific validity of this ... known cases of idiopathic dilated cardiomyopathy who received placebo. Drug: Placebo dose of 2 mg/kg/day in 2 or 3 divided ...
Join friendly people sharing 39 true stories in the I Have Dilated Cardiomyopathy group. Find support forums, advice and chat ... Dilated Cardiomyopathy Ef 24% My husband (36 yrs) was just diagnosed 1 month ago w/ CHF dilated cardiomyopathy. His ef is 24 % ... Dilated Cardiomyopathy @ 23 hi there. i have recently found out i have dilated cardiomyopathy. i was tested as my mother was ... Dilated Cardiomyopathy I am 36 years old and was recently diagnosed with idiopathic dilated cardiomyopathy. I have been in good ...
Results of comprehensive diagnostic work-up in idiopathic dilated cardiomyopathy. dc.date.accessioned. 2016-04-20T12:30:50Z. ... Objective Dilated cardiomyopathy (DCM) is characterised by left ventricular dilation and dysfunction not caused by coronary ... Broch, Kaspar (2016) Dilated cardiomyopathy: diagnostic work-up, pathogenesis, prognosis and treatment. Doctoral thesis. http ... Results of comprehensive diagnostic work-up in idiopathic dilated cardiomyopathy. en_US. ...
Dilated cardiomyopathy (DCM) - Reference pathway Help. [ Pathway menu , Organism menu , Pathway entry , Show description , ... Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ...
Humes on is dilated cardiomyopathy curable: Depends on how severe it is. Milder forms can be controlled with medications, which ... Doctors give advice for those with Dilated who are concerned about Cardiomyopathy: Dr. ... Dilated Cardiomyopathy (Definition) Dilated means that the heart is enlarged, & cardiomyopathy means sick heart muscle. There ... Cardiomyopathy: Dilated cardiomyopathy is a weak heart condition. It is serious and requires long term treatment. It is caused ...
Is this true? My uncle had been diagnosed with dilated cardiomyopathy (with EF of 39%), when he was 45 years old. His reports ... idiopathic dilated cardiomyopathy,/b,. An ECG, echo-cardiogram and subsequently cardio-angio-graph was done, EF was 35%. The ... Q: My family member aged 62 years has been diagnosed with idiopathic dilated cardiomyopathy. An ECG, echo-cardiogram and ... Is this true? My uncle had been diagnosed with dilated cardiomyopathy (with EF of 39%), when he was 45 years old. His reports ...
... What is Dilated Cardiomyopathy?. Dilated Cardiomyopathy (DCM) is a disease process that affects the ... Special testing for taurine levels may be indicated in animals suspected of dilated cardiomyopathy secondary to nutritional ... The heart muscle overtime becomes dilated or stretched and can no longer pump blood efficiently. This disease is characterized ...
Cardiomyopathy is disease in which the heart muscle becomes weakened, stretched, or has another structural problem. ... Cardiomyopathy - dilated; Primary cardiomyopathy; Diabetic cardiomyopathy; Idiopathic cardiomyopathy; Alcoholic cardiomyopathy ... called idiopathic dilated cardiomyopathy. There is no known cause for this type of dilated cardiomyopathy. ... There are many types of cardiomyopathy. Dilated cardiomyopathy is the most common form, but it may be the result of different ...
Familial dilated cardiomyopathy is a genetic form of heart disease. Explore symptoms, inheritance, genetics of this condition. ... medlineplus.gov/genetics/condition/familial-dilated-cardiomyopathy/ Familial dilated cardiomyopathy. ... Familial dilated cardiomyopathy. is a genetic form of heart disease. It occurs when heart (cardiac) muscle. becomes thin and ... People with familial dilated cardiomyopathy often do not have an identified mutation in any of the known associated genes. The ...
The right ventricle may also be dilated and dysfun... more ... Dilated cardiomyopathy is a progressive disease of heart muscle ... Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study ... Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25. 121(20):2169-75. [Medline]. ... The right ventricle may also be dilated and dysfunctional. Dilated cardiomyopathy is the third most common cause of heart ...
The right ventricle may also be dilated and dysfun... more ... Dilated cardiomyopathy is a progressive disease of heart muscle ... encoded search term (How is dilated cardiomyopathy characterized?) and How is dilated cardiomyopathy characterized? What to ... Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study ... Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25. 121(20):2169-75. [Medline]. ...
This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines ... of Dilated Cardiomyopathy Arrhythmias in dilated cardiomyopathies follow-up in dilated cardiomyopathy Open issues in dilated ... Imaging in Dilated Cardiomyopathy Echocardiography in Dilated Cardiomyopathy Endomyocardial biopsy in Dilated Cardiomyopathy ... Etiology of Dilated Cardiomyopathy Regenerative Medicine and dilated cardiomyopathy Multidisciplinary approach to Dilated ...
... and treatment of dilated cardiomyopathy, a condition in which the hearts ability to pump blood is decreased. ... Dilated cardiomyopathy (DCM) is when the hearts ability to pump blood is lessened because its main pumping chamber, the left ... Many people with dilated cardiomyopathy have no symptoms. Some that do have only minor ones, and live a normal life. Others ... If you have a relative with dilated cardiomyopathy, ask your doctor if you should be screened for it. Genetic testing may also ...
... it is also the most common cardiomyopathy encountered. The condition can be a result of underlying diseases,... ... Dilated cardiomyopathy (DCM) is a significant burden affecting 5 people in 100,000, ... Dilated cardiomyopathy (DCM) is a significant burden affecting 5 people in 100,000, it is also the most common cardiomyopathy ... Right ventricular dilated cardiomyopathy. Br Heart J. 1984;51(1):25-9.CrossRefPubMedPubMedCentralGoogle Scholar ...
dilated cardiomyopathy. dear sir i am suffering from dcm , my lvef is 29 % i have gone for crt is there any treatment for dcm ... Dilated cardiomyopathy is an enlarged left ventricle and that condition will reduce the EF. Usually that condition develops ... Dilated cardiomyopathy is an enlarged left ventricle and that condition will reduce the EF. Usually that condition develops ... Several years ago, I had dcm and other heart issues...medication that dilate the vessels reduces the resistance, and medication ...
Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations in many genes. TTN, the gene encoding the sarcomere ... We analyzed TTN in 312 subjects with dilated cardiomyopathy, 231 subjects with hypertrophic cardiomyopathy, and 249 controls by ... Truncations of titin causing dilated cardiomyopathy.. Herman DS1, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, ... Mutations associated with dilated cardiomyopathy were overrepresented in the titin A-band but were absent from the Z-disk and M ...
Cardiomyopathy? Below is a list of common natural remedies used to treat or reduce the symptoms of Dilated+Cardiomyopathy. ... Considering taking a vitamin or supplement to treat Dilated+ ... 5 results found for Dilated+Cardiomyopathy. Treatment name. ...
The right ventricle may also be dilated and dysfunctional. ... Dilated cardiomyopathy is a progressive disease of heart muscle ... encoded search term (Dilated Cardiomyopathy) and Dilated Cardiomyopathy What to Read Next on Medscape ... Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study ... Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. Circulation. 2010 May 25. 121(20):2169-75. [Medline]. ...
Dilated cardiomyopathy is a progressive, usually irreversible, disease causing global systolic (contractile) dysfunction with ... encoded search term (Dilated Cardiomyopathy Pathology) and Dilated Cardiomyopathy Pathology What to Read Next on Medscape. ... Familial dilated cardiomyopathy, which is considered to be responsible for at least 25% of cases of dilated cardiomyopathy, [1 ... The clinical picture and prognosis of mildly dilated cardiomyopathy are very similar to those of typical dilated cardiomyopathy ...
Dilated Cardiomyopathy (DCM) This information is not meant to be a substitute for veterinary care. Always follow the ...
... into the issue of dilated cardiomyopathy in dogs eating certain pet foods in a high level of technical detail suited for ... In July 2018, the FDA alerted the public about an investigation into reports of canine dilated cardiomyopathy (DCM) in dogs ... Journal of American Veterinary Medical Association - Diet-associated dilated cardiomyopathy in dogs: what do we know? (December ... FDA Investigation into Potential Link between Certain Diets and Canine Dilated Cardiomyopathy (June 2019) ...
Dilated cardiomyopathy is a common cause of heart failure, which happens when the heart cant adequately supply the body with ... George Michaels Death: What Causes Dilated Cardiomyopathy?. By Rachael Rettner 2017-03-08T22:38:14Z. Health ... Dilated cardiomyopathy is a condition that affects the heart muscle, and myocarditis means inflammation of the heart wall. ... In people with dilated cardiomyopathy, the heart muscle stretches and becomes thinner, according to the American Heart ...
The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med. ... families with familial idiopathic dilated cardiomyopathy and families with non-familial idiopathic dilated cardiomyopathy. ... Idiopathic Dilated Cardiomyopathy. The safety and scientific validity of this study is the responsibility of the study sponsor ... In 1987 idiopathic dilated cardiomyopathy was a disorder of unknown cause that directly affected one or both cardiac ventricles ...
Dilated cardiomyopathy Open pop-up dialog box Close Dilated cardiomyopathy. Dilated cardiomyopathy. Compared with a normal ... The cause of dilated cardiomyopathy often cant be determined. However, numerous factors can cause the left ventricle to dilate ... Healthy lifestyle habits can help you prevent or minimize the effects of dilated cardiomyopathy. If you have dilated ... Complications from dilated cardiomyopathy include:. *Heart failure. Poor blood flow from the left ventricle can lead to heart ...
In dilated cardiomyopathy, which is a frequent cause of heart transplantation, unraveling the specific comb… ... Proteomic signature of circulating extracellular vesicles in dilated cardiomyopathy. *Santiago Roura1. ,2. ,3. na1, ... Dilated cardiomyopathy (DCM) remains a major cause of heart failure and carries a poor prognosis despite important advances in ... Idiopathic dilated cardiomyopathy exhibits defective vascularization and vessel formation. Eur J Heart Fail. 2007;9:995-1002. ...
... ischaemic dilated cardiomyopathy. AbstractAimContemporary survival trends in dilated cardiomyopathy (DCM) are largely unknown. ... ischemic Dilated Cardiomyopathy. AbstractBackgroundContemporary survival trends of Dilated Cardiomyopathy (DCM) patients are ... AbstractPurpose of reviewIn this review, we will focus the role of CMR in dilated cardiomyopathy and genetic cardiomyopathy. ... A total of 215 patients with CHF (124 ischemic cardiomyopathy (ICM) and 91 dilated cardiomyopathy (DCM)) and 215 healthy ...
Genetic causes of dilated cardiomyopathy Valentina Favalli, Alessandra Serio, Maurizia Grasso, Eloisa Arbustini ... combined with delayed-enhancement magnetic resonance improves risk stratification in patients with dilated cardiomyopathy ...
A rare cause of reversible dilated cardiomyopathy: hypocalcemia.. Avsar A1, Dogan A, Tavli T. ...
In contrast, dilated cardiomyopathy (DCM) is far more genetically heterogeneous, with mutations in genes encoding cytoskeletal ... In hypertrophic cardiomyopathy (HCM), cardiac output is limited by the thickened myocardium through impaired filling and ... Genetic mutations account for a significant percentage of cardiomyopathies, which are a leading cause of congestive heart ...
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the body. Treatment aims to ... Hypertrophic Cardiomyopathy: In this condition the heart muscles get thicker making it harder for blood to leave.. ► Dilated ... Cardiomyopathy is classified into three morphologic types: dilated, restrictive, and hypertrophic. When the exact cause is not ... TNNT2 Gene Polymorphisms Are Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in the Han Chinese Population. ...
Cardiomyopathy - dilated; Primary cardiomyopathy; Diabetic cardiomyopathy; Idiopathic cardiomyopathy; Alcoholic cardiomyopathy ... There are many types of cardiomyopathy. Dilated cardiomyopathy is the most common form. ... Dilated cardiomyopathy is a condition in which the heart muscle becomes weakened and enlarged. As a result, the heart cannot ... The dilated, restrictive, and infiltrative cardiomyopathies. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald ...
Dilated cardiomyopathy involves enlargement of the heart muscle and is the most common type of cardiomyopathy. The heart muscle ...
Dilated cardiomyopathy (DCM) is a disease of the heart muscle in which the heart becomes thin walled and dilated. There are two ... Dilated cardiomyopathy (DCM) is disease of the heart muscle in which the heart becomes thin walled and dilated. There are two ... Outline: Dilated cardiomyopathy (DCM) is disease of the heart muscle in which the heart becomes thin walled and dilated. Dogs ... Figure 3. In cases of dilated cardiomyopathy, the ventricles dilate and become larger, and the cardiac muscle surrounding them ...
Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Thomas L. Lynch IV,1 Mayandi Sivaguru,2 Murugesan ... Qin Yu, Rongmei Na, Baiting Liu, and Qianxiao Li, "Omega-3 polyunsaturated fatty acids prevent murine dilated cardiomyopathy by ... "Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation," Journal of Molecular and Cellular Cardiology ... Paul Wijnker, Vasco Sequeira, Diederik Kuster, and Jolanda van der Velden, "Hypertrophic cardiomyopathy: a vicious cycle ...
Dilated Cardiomyopathy and The Role of Autoimmunity in Cardiovascular Diseases. 716 Words3 Pages ... More about Dilated Cardiomyopathy and The Role of Autoimmunity in Cardiovascular Diseases. ... It is well established that cardiomyopathy can be recapitulated by experimental immunization with cardiac myosin plus an ... partial epitopes to induce potentially harmful anti-M2AChR-el2 and anti-M2AChR-il3 antibodies and establish cardiomyopathy. All ...
  • Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. (kegg.jp)
  • An icd ( defibrillator ) may rescue you from cardiac arrest , which is a risk one carries with cardiomyopathy - but it doesn't cure cardiomyopathy. (healthtap.com)
  • 35%), e. g. after myocarditis, dilated cardiomyopathy, acute myocardial infarction, in patients with postpartum cardiomyopathy or implantable cardioverter-defibrillator (ICD) and cardiac resynchronization treatment plus defibrillator (CRT-D) infection with temporary explantation of the system is a medical challenge. (readbyqxmd.com)
  • Lamin A/C gene (LMNA) associated cardiomyopathy is a form of dilated cardiomyopathy with poor prognosis and high mortality, and a rapid evolution toward end-stage heart failure and malignant ventricular arrhythmias associated with increased risk of sudden cardiac death. (medpharmareports.com)
  • Join us this September in raising awareness of pediatric cardiomyopathy, the number one cause of sudden cardiac arrest and heart transplants in children. (childrenscardiomyopathy.org)
  • Know the signs and symptoms of cardiomyopathy to help identify children who may be at risk for a sudden cardiac arrest. (childrenscardiomyopathy.org)
  • It includes types of cardiomyopathy that are not related to coronary artery disease. (stdavids.com)
  • Canines suffer from two types of cardiomyopathy: dilated cardiomyopathy and hypertrophic cardiomyopathy. (bowwowinsurance.com.au)
  • Share this fact: #KnowYourHeart Symptoms can vary widely with different types of cardiomyopathy. (childrenscardiomyopathy.org)
  • There are many other types of cardiomyopathy that can be classified by what causes the heart muscle problem. (uncmedicalcenter.org)
  • Furthermore, other cytoskeletal proteins, such as adhalin, could be involved in the pathogenesis of familial dilated cardiomyopathy, In familial right ventricular cardiomyopathy (or arrhythmogenic right ventricular dysplasia) characterized by isolated or prevalent right ventricular involvement, three different disease loci have been identified so far : two localized on the long arm of chromosome 14 and one on chromosome 1. (ac.rs)
  • The DCM Research Project was started in 1993, first named the Familial Dilated Cardiomyopathy Research Project, with the singular focus to gather very large families with multiple individuals affected with DCM. (dcmproject.com)
  • From 1993 - 2013, the research study of the Project was entitled "The Familial Dilated Cardiomyopathy (FDC) Study. (dcmproject.com)
  • Rodeheffer, Richard J. / Familial Dilated Cardiomyopathy . (elsevier.com)
  • There are many reasons for the heart muscle to get weak/dilated including genetic disorders, certain inflammatory conditions, & toxins including alcohol. (healthtap.com)
  • The disease genes are still unknown and are currently under investigation, The study of the genetic factors at the molecular level is starting to elucidate the pathogenetic mechanisms of idiopathic dilated cardiomyopathy, These findings will also have relevant clinical and therapeutic implications. (ac.rs)
  • 1 Epidemiologic studies have suggested that blacks may be at increased risk for idiopathic dilated cardiomyopathy, although few genetic studies of this disease have been undertaken in multiracial populations. (elsevier.com)
  • If the diagnosis is correct, all forms of hypertrophic cardiomyopathy aren't curable in the sense that it will just get better and go away. (healthtap.com)
  • Dilated cardiomyopathy (DCM) is a general diagnosis provided for a heart that is enlarged with decreased pumping function/contractility (i.e. systolic dysfunction). (vetspecialty.com)
  • Tampa General Hospital's Cardiovascular Center provides the latest advances in cardiomyopathy diagnosis and treatment. (tgh.org)
  • Known cases of idiopathic dilated cardiomyopathy who received supplementation of coenzyme Q10 as a part of their medical regimen. (clinicaltrials.gov)
  • The Cardiomyopathy Registry of the EURObservational Research Programme is a prospective, observational, and multinational registry of consecutive patients with four cardiomyopathy subtypes: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and restrictive cardiomyopathy (RCM). (readbyqxmd.com)
  • Share this fact: #KnowYourHeart There are five different forms of cardiomyopathy: dilated, hypertrophic, restrictive, arrhythmogenic right ventricular and left ventricular non-compaction. (childrenscardiomyopathy.org)
  • Arrhythmogenic right ventricular dysplasia - Treatment for this type of cardiomyopathy may involve medications to help control heart rhythms or the placement of an ICD. (tgh.org)
  • Symptoms vary, depending on the type of cardiomyopathy and its severity. (stdavids.com)
  • Treatment for cardiomyopathy depends on the type of cardiomyopathy and the type of heart problems that occur as a result of the changes in the heart muscle. (uncmedicalcenter.org)
  • The specifics of cardiomyopathy treatment vary according to the type of cardiomyopathy present and the overall health of the patient. (tgh.org)
  • Hypertrophic cardiomyopathy - Physicians may suggest several treatments for this type of cardiomyopathy, including medication to maintain a healthy heart rhythm and the placement of an implantable cardioverter-defibrillator (ICD) that emits gentle electric shocks to correct abnormal rhythms. (tgh.org)
  • ped to chromosome 1 and 3, respectively, The identification of the disease genes is in progress, In families with X-linked dilated cardiomyopathy, the disease gene has been identified as the dystrophin gene, The 5' end of the gene appears to be the critical region for the development of dilated cardiomyopathy without clinical evidence of muscle dystrophy. (ac.rs)
  • There are many diseases that can cause a heart to dilate including coronary artery disease, valvular heart disease, metabolic diseases of the heart, infections and in some cases the cause is not determined. (medmovie.com)
  • Objective Dilated cardiomyopathy (DCM) is characterised by left ventricular dilation and dysfunction not caused by coronary disease, valvular disease or hypertension. (uio.no)
  • This type includes alcoholic cardiomyopathy and also peripartum cardiomyopathy, which can happen during or after pregnancy. (uncmedicalcenter.org)
  • Restrictive cardiomyopathy - Patients with this form of cardiomyopathy are often given medications to address symptoms, reduce blood pressure, and correct abnormal heart rhythms. (tgh.org)
  • Dilated cardiomyopathy is the most common form of cardiomyopathy. (heart.org)
  • Apical hypertrophic cardiomyopathy is a form of hypertrophic cardiomyopathy whereby the thickening is localized at the tip of the left ventricle. (healthtap.com)
  • Cardiomyopathy can also occur as a result of other diseases (such as a heart infection), medications (such as certain anti-cancer drugs), or exposure to a toxin. (bowwowinsurance.com.au)
  • There are two categories of cardiomyopathy: ischemic and non-ischemic. (stdavids.com)
  • Share this fact: #KnowYourHeart Cardiomyopathy in children can either be inherited genetically through one or both parents or acquired through a viral infection or cancer chemotherapy. (childrenscardiomyopathy.org)
  • It is evident that dilated cardiomyopathy in dogs is fairly widespread among certain large breeds and the disease is therefore assumed to have a hereditary component. (bowwowinsurance.com.au)
  • Secondary mitral regurgitation (MR) is a common finding in patients with dilated cardiomyopathy, and it is associated with poor outcomes. (readbyqxmd.com)
  • Share this fact: #KnowYourHeart Cardiomyopathy can occur in any child regardless of age, race, gender or socioeconomic background. (childrenscardiomyopathy.org)
  • Cardiomyopathy may occur as a result of damage to the heart, such as from a heart attack, or a person may inherit the tendency to develop it. (uncmedicalcenter.org)
  • Is apical hypertrophic cardiomyopathy uncurable? (healthtap.com)
  • Is apical hypertrophic cardiomyopathy an incurable disease? (healthtap.com)