Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Cardiomyopathy, Hypertrophic: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).Alcoholics: Persons who have a history of physical or psychological dependence on ETHANOL.Cardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.Cardiomyopathy, Restrictive: A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis.Takotsubo Cardiomyopathy: A transient left ventricular apical dysfunction or ballooning accompanied by electrocardiographic (ECG) T wave inversions. This abnormality is associated with high levels of CATECHOLAMINES, either administered or endogenously secreted from a tumor or during extreme stress.Cardiomyopathy, Alcoholic: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).Fatty Liver, Alcoholic: Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.Pancreatitis, Alcoholic: Acute or chronic INFLAMMATION of the PANCREAS due to excessive ALCOHOL DRINKING. Alcoholic pancreatitis usually presents as an acute episode but it is a chronic progressive disease in alcoholics.Alcoholic Beverages: Drinkable liquids containing ETHANOL.Cardiomyopathy, Hypertrophic, Familial: An autosomal dominant inherited form of HYPERTROPHIC CARDIOMYOPATHY. It results from any of more than 50 mutations involving genes encoding contractile proteins such as VENTRICULAR MYOSINS; cardiac TROPONIN T; ALPHA-TROPOMYOSIN.Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)Alcoholics Anonymous: An organization of self-proclaimed alcoholics who meet frequently to reinforce their practice of abstinence.Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Ethanol: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.Arrhythmogenic Right Ventricular Dysplasia: A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.Temperance: Habitual moderation in the indulgence of a natural appetite, especially but not exclusively the consumption of alcohol.Diabetic Cardiomyopathies: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Alcoholic Neuropathy: A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)Psychoses, Alcoholic: A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Myocarditis: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Heart Septum: This structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Ventricular Outflow Obstruction: Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.Alcohol Amnestic Disorder: A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)Myocardial Contraction: Contractile activity of the MYOCARDIUM.Heart: The hollow, muscular organ that maintains the circulation of the blood.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Cardiac Myosins: Myosin type II isoforms found in cardiac muscle.Beer: An alcoholic beverage usually made from malted cereal grain (as barley), flavored with hops, and brewed by slow fermentation.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Peripartum Period: The period shortly before, during, and immediately after giving birth.Wernicke Encephalopathy: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)Echocardiography, Doppler: Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.Ventricular Myosins: Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Sarcomeres: The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.Endomyocardial Fibrosis: A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Myosin Heavy Chains: The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.Hypertrophy, Left Ventricular: Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Endocardium: The innermost layer of the heart, comprised of endothelial cells.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Alcoholic Intoxication: An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.Plakophilins: Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.Alcohol Withdrawal Delirium: An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)Heart Transplantation: The transference of a heart from one human or animal to another.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Lamin Type A: A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during mitosis.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Diastole: Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.Sarcoglycans: A family of transmembrane dystrophin-associated proteins that play a role in the membrane association of the DYSTROPHIN-ASSOCIATED PROTEIN COMPLEX.Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.Magnetic Resonance Imaging, Cine: A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Desmoglein 2: A CALCIUM-dependent adhesion molecule of DESMOSOMES that also plays a role in embryonic STEM CELL proliferation.Central Nervous System Depressants: A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Systole: Period of contraction of the HEART, especially of the HEART VENTRICLES.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Glycogen Storage Disease Type IIb: An X-linked dominant multisystem disorder resulting in cardiomyopathy, myopathy and INTELLECTUAL DISABILITY. It is caused by mutation in the gene encoding LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Isolated Noncompaction of the Ventricular Myocardium: Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.Pregnancy Complications, Cardiovascular: The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.Desmin: An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Dystrophin: A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.Ventricular Dysfunction: A condition in which HEART VENTRICLES exhibit impaired function.Adrenergic beta-Antagonists: Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.Mitral Valve: The valve between the left atrium and left ventricle of the heart.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mitral Valve Insufficiency: Backflow of blood from the LEFT VENTRICLE into the LEFT ATRIUM due to imperfect closure of the MITRAL VALVE. This can lead to mitral valve regurgitation.Ablation Techniques: Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Cardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Catheter Ablation: Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Cytochrome P-450 CYP2E1: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Liver Diseases: Pathological processes of the LIVER.Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)Liver Function Tests: Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)Epicardial Mapping: Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.Tropomyosin: A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Electrocardiography, Ambulatory: Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.Ventricular Dysfunction, Right: A condition in which the RIGHT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE or MYOCARDIAL INFARCTION, and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the right ventricular wall.Connectin: A giant elastic protein of molecular mass ranging from 2,993 kDa (cardiac), 3,300 kDa (psoas), to 3,700 kDa (soleus) having a kinase domain. The amino- terminal is involved in a Z line binding, and the carboxy-terminal region is bound to the myosin filament with an overlap between the counter-connectin filaments at the M line.Alcohol Abstinence: Non-consumption of ALCOHOLIC BEVERAGES.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Myofibrils: The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .Mitochondria, Heart: The mitochondria of the myocardium.Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.Bundle-Branch Block: A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.Electrophysiologic Techniques, Cardiac: Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Echocardiography, Doppler, Color: Echocardiography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image.Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.Coxsackievirus Infections: A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.Pericarditis, Constrictive: Inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Propanolamines: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Heart-Assist Devices: Small pumps, often implantable, designed for temporarily assisting the heart, usually the LEFT VENTRICLE, to pump blood. They consist of a pumping chamber and a power source, which may be partially or totally external to the body and activated by electromagnetic motors.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS.Genetic Testing: Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.Echocardiography, Doppler, Pulsed: Echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.Child of Impaired Parents: Child with one or more parents afflicted by a physical or mental disorder.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)IodobenzenesDesmocollins: A group of desmosomal cadherins with cytoplasmic tails that are divergent from those of classical CADHERINS. Their intracytoplasmic domains bind PLAKOGLOBIN; PLAKOPHILINS; and DESMOPLAKINS.LIM Domain Proteins: A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Hyalin: A clear, homogenous, structureless, eosinophilic substance occurring in pathological degeneration of tissues.Desmoplakins: Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Noonan Syndrome: A genetically heterogeneous, multifaceted disorder characterized by short stature, webbed neck, ptosis, skeletal malformations, hypertelorism, hormonal imbalance, CRYPTORCHIDISM, multiple cardiac abnormalities (most commonly including PULMONARY VALVE STENOSIS), and some degree of INTELLECTUAL DISABILITY. The phenotype bears similarities to that of TURNER SYNDROME that occurs only in females and has its basis in a 45, X karyotype abnormality. Noonan syndrome occurs in both males and females with a normal karyotype (46,XX and 46,XY). Mutations in a several genes (PTPN11, KRAS, SOS1, NF1 and RAF1) have been associated the the NS phenotype. Mutations in PTPN11 are the most common. LEOPARD SYNDROME, a disorder that has clinical features overlapping those of Noonan Syndrome, is also due to mutations in PTPN11. In addition, there is overlap with the syndrome called neurofibromatosis-Noonan syndrome due to mutations in NF1.Receptors, Adrenergic, beta-1: A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-1 receptors are equally sensitive to EPINEPHRINE and NOREPINEPHRINE and bind the agonist DOBUTAMINE and the antagonist METOPROLOL with high affinity. They are found in the HEART, juxtaglomerular cells, and in the central and peripheral nervous systems.Desmosomes: A type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990; Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Ventricular Pressure: The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.Muscle Proteins: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.Carbazoles: Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Dobutamine: A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.Ventricular Premature Complexes: A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.Aspartate Aminotransferases: Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Mice, Inbred C57BLGenetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)Muscular Dystrophies: A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Ventricular Septum: The muscular structure separating the right and the left lower chambers (HEART VENTRICLES) of the heart. The ventricular septum consists of a very small membranous portion just beneath the AORTIC VALVE, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum.Penetrance: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)Radionuclide Ventriculography: Imaging of a ventricle of the heart after the injection of a radioactive contrast medium. The technique is less invasive than cardiac catheterization and is used to assess ventricular function.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Pellagra: A disease due to deficiency of NIACIN, a B-complex vitamin, or its precursor TRYPTOPHAN. It is characterized by scaly DERMATITIS which is often associated with DIARRHEA and DEMENTIA (the three D's).Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.Alcohol Deterrents: Substances interfering with the metabolism of ethyl alcohol, causing unpleasant side effects thought to discourage the drinking of alcoholic beverages. Alcohol deterrents are used in the treatment of alcoholism.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Mitochondrial Myopathies: A group of muscle diseases associated with abnormal mitochondria function.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Sarcoplasmic Reticulum Calcium-Transporting ATPases: Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.Organ Size: The measurement of an organ in volume, mass, or heaviness.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.Heart Aneurysm: A localized bulging or dilatation in the muscle wall of a heart (MYOCARDIUM), usually in the LEFT VENTRICLE. Blood-filled aneurysms are dangerous because they may burst. Fibrous aneurysms interfere with the heart function through the loss of contractility. True aneurysm is bound by the vessel wall or cardiac wall. False aneurysms are HEMATOMA caused by myocardial rupture.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

A transgenic model of acetaldehyde overproduction accelerates alcohol cardiomyopathy. (1/44)

Chronic alcohol consumption produces alcoholic heart muscle disease (AHMD), a prevalent form of congestive heart failure. Several hypotheses have been proposed to explain the damaging effects of alcohol on the heart, but neither the mechanism nor the ultimate toxin has been established. In this study, we use transgenic overexpression of alcohol dehydrogenase to elevate cardiac exposure to acetaldehyde, the major and most reactive metabolite of alcohol. Overexpression of alcohol dehydrogenase by 40-fold produced no detectable deleterious effects to the heart in the absence of alcohol. In the presence of alcohol, transgenic hearts contained 4-fold higher acetaldehyde than control hearts. Chronic alcohol exposure produced many changes similar to AHMD in transgenic hearts. Compared with control hearts, these pathological changes occurred more rapidly and to a greater extent: alcohol-exposed transgenic hearts were almost twice as large as control hearts. They demonstrated ultrastructural damage consistent with AHMD and had much lower contractility than alcohol-exposed control hearts. In addition, the transgenic hearts showed greater changes in mRNA expression for alpha-skeletal actin and atrial natriuretic factor than alcohol-exposed control hearts. Alterations in NAD(+)/NADH levels were insufficient to account for such severe damage in cardiomyopathic hearts. The increased damage produced in transgenic hearts suggests an important role for acetaldehyde in AHMD.  (+info)

A pilot study of a new chicken model of alcohol-induced cardiomyopathy. (2/44)

BACKGROUND: Excessive alcohol consumption is recognized as a common cause of left ventricular (LV) dysfunction. It is currently thought that 36% of all cases of dilated cardiomyopathy are due to excessive alcohol intake. Suitable animal models are needed to study the pathogenic mechanisms of ethanol-induced LV dysfunction. We have therefore created a new model of ethanol-induced LV dysfunction in the chicken. METHODS: For 12 weeks, adult chickens were given, twice a day, by gavage, 73% of their total calculated daily water intake containing a 20% ethanol concentration. Twenty percent ethanol also was placed in the water and provided ad libitum. Control chickens received the same volume of water by gavage twice a day without ethanol. Water without ethanol was given ad libitum to control birds. RESULTS: Our study shows that after a relatively short duration of ethanol ingestion, chickens developed LV dilatation and LV dysfunction. The serum concentrations of ethanol attained in this new model were similar to those reported in humans. Furthermore, unlike other currently available animal models of ethanol-induced cardiac disease, this model demonstrates myocyte hypertrophy, interstitial fibrosis, and myocytolysis, similar to observations in human ethanol-induced cardiac dysfunction. CONCLUSIONS: We conclude that this new avian model should provide a useful tool for investigating the mechanism(s) and pathophysiology of ethanol-induced dilated cardiomyopathy and heart failure.  (+info)

Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy. (3/44)

AIMS: The outcome of alcoholic cardiomyopathy is thought to be better than idiopathic dilated cardiomyopathy if patients abstain from alcohol. The aim of this study was to compare the long-term clinical outcome of alcoholic and idiopathic dilated cardiomyopathy. METHODS AND RESULTS: Of 134 patients with dilated cardiomyopathy and normal coronary angiography, 50 had alcoholic cardiomyopathy; they were compared serially to 84 patients with idiopathic dilated cardiomyopathy. Left ventricular end-diastolic diameter, left ventricular ejection fraction and cardiac index, severity of ventricular arrhythmias, measurement of heart rate variability and results of signal-averaged ECG were similar in both groups. Although alcohol withdrawal was strongly recommended but observed in only 70% of patients with alcoholic cardiomyopathy, both groups had similar outcome in terms of cardiac death after follow-up treatment of 47+/-40 months. Multivariate analysis in the entire cohort demonstrated that increased pulmonary capillary wedge pressure (P=0. 003), alcoholism and lack of abstinence during follow-up (P=0.006) and decreased standard deviation of all normal-to-normal RR intervals (P=0.02) were independent predictors of cardiac death. CONCLUSION: In contrast with previous studies, patients with alcoholic cardiomyopathy did not have a better outcome than patients with idiopathic dilated cardiomyopathy. Alcoholism without abstinence was a strong predictor of cardiac death. This suggests that a more aggressive approach to alcohol cessation is needed in these patients.  (+info)

Early changes in left ventricular function in chronic asymptomatic alcoholics: relation to the duration of heavy drinking. (4/44)

OBJECTIVES: This study sought to assess preclinical cardiac abnormalities in chronic alcoholic patients and possible differences among alcoholics related to the duration of heavy drinking. BACKGROUND: Chronic excessive alcohol intake has been reported as a possible cause of dilated cardiomyopathy. However, before the appearance of severe cardiac dysfunction, subtle signs of cardiac abnormalities may be identified. METHODS: We studied 30 healthy subjects (age 44 +/- 8 years) and 89 asymptomatic alcoholics (age 45 +/- 8 years, p = NS) divided into three groups, with short (S, 5-9 years, n = 31), intermediate (I, 10-15 years, n = 31) and long (L, 16-28 years, n = 27) duration of alcoholism. Transmitral early (E) and late (A) Doppler flow velocities, E/A ratio, deceleration time of E (DT) and isovolumic relaxation time (IVRT) were obtained. Left ventricular (LV) wall thickness and volumes were also determined by echocardiography, and LV mass and ejection fraction (EF) were calculated. RESULTS: The alcoholics had prolonged IVRT (92 +/- 11 vs. 83 +/- 7 ms, p < 0.001), longer DT (180 +/- 20 vs. 170 +/- 10 ms, p < 0.01), smaller E/A (1.25 +/- 0.34 vs. 1.40 +/- 0.32, p < 0.05), larger LV volumes (73 +/- 8 vs. 65 +/- 7 ml/m2, p < 0.001 for end-diastolic volume index; 25 +/- 4 vs. 21 +/- 2 ml/m2, p < 0.001 for end-systolic volume index), higher LV mass index (92 +/- 14 vs. 78 +/- 8 g/m2, p < 0.001) and thicker posterior wall (9 +/- 1 vs. 8 +/- 1 mm, p < 0.001). Ejection fraction did not differ between the two groups (66 +/- 4 vs. 67 +/- 2%). Deceleration time of the early transmitral flow velocity was longer in groups L (187 +/- 18 ms) and I (185 +/- 16 ms) compared with group S (168 +/- 17 ms, p < 0.001 for L and I vs. S), whereas A was higher in group L compared with S (43 +/- 10 vs. 51 +/- 10 cm/s, p < 0.005). Multiple regression analysis identified duration of heavy drinking as the most important variable affecting DT and A. CONCLUSIONS: Left ventricular dilation with preserved EF and impaired LV relaxation characterized LV function in chronic asymptomatic alcoholic patients. It appeared that the progression of abnormalities in LV diastolic filling related to the duration of alcoholism.  (+info)

Metabolic cardiomyopathies. (5/44)

The energy needed by cardiac muscle to maintain proper function is supplied by adenosine Ariphosphate primarily (ATP) production through breakdown of fatty acids. Metabolic cardiomyopathies can be caused by disturbances in metabolism, for example diabetes mellitus, hypertrophy and heart failure or alcoholic cardiomyopathy. Deficiency in enzymes of the mitochondrial beta-oxidation show a varying degree of cardiac manifestation. Aberrations of mitochondrial DNA lead to a wide variety of cardiac disorders, without any obvious correlation between genotype and phenotype. A completely different pathogenetic model comprises cardiac manifestation of systemic metabolic diseases caused by deficiencies of various enzymes in a variety of metabolic pathways. Examples of these disorders are glycogen storage diseases (e.g. glycogenosis type II and III), lysosomal storage diseases (e.g. Niemann-Pick disease, Gaucher disease, I-cell disease, various types of mucopolysaccharidoses, GM1 gangliosidosis, galactosialidosis, carbohydrate-deficient glycoprotein syndromes and Sandhoff's disease). There are some systemic diseases which can also affect the heart, for example triosephosphate isomerase deficiency, hereditary haemochromatosis, CD 36 defect or propionic acidaemia.  (+info)

Dose dependent but non-linear effects of alcohol on the left and right ventricle. (6/44)

OBJECTIVE: To assess how left (LV) and right ventricular (RV) size, wall thickness, and mass depend on daily alcohol consumption. Among alcoholics, most common findings have been LV hypertrophy and mild systolic or diastolic dysfunction, accompanied occasionally by ventricular dilatation resembling dilated cardiomyopathy. Although it is commonly agreed that chronic heavy alcohol use is injurious to the heart, the dose-injury relation remains a matter of dispute. DESIGN: Prospective series of 700 Finnish men aged 33-70 years who died out of hospital and underwent a medicolegal necropsy. METHODS AND RESULTS: Data on alcohol use and other risk factors were obtained from the spouse. At necropsy, a transversal slice of the heart was traced on a transparent sheet and analysed later for LV and RV cavity areas and wall thicknesses. Coronary artery stenoses were measured from silicone casts of the arteries. In analyses of all men, daily alcohol dose predicted heart weight (beta = 0.17, p < 0.001) and RV cavity area (beta = 0.14, p = 0.007) independent of body size, age, coronary artery disease, hypertension, diabetes, and smoking. In the subgroup of men free of significant coronary artery disease, LV area averaged (SEM) 11.0 (1.0) cm(2) in men drinking < 12 g/day, 7.7 (0.7) cm(2) in those drinking 72-180 g/day, and 10.0 (0.9) cm(2) in those drinking > 180 g/day (p = 0.054). Very heavy drinking (> 180 g/day) was associated with an increase in RV cavity area (p = 0.005). CONCLUSIONS: The effects of alcohol on the heart in middle aged men are dose dependent but partly non-linear. In the absence of coronary artery disease, LV size shows a U shaped reduction with increasing daily alcohol use accompanied by an increase in RV size with very heavy drinking. These findings question the idea of progressive LV dilatation with increasing alcohol consumption among male victims of sudden death.  (+info)

Mitochondria enter the nucleus (one further problem in chronic alcoholism). (7/44)

Electron microscopy of cardiomyocytes of patients with hypertrophic and alcoholic cardiomyopathies revealed the presence of nuclei with mitochondria accumulated in their core. This was associated with chromatin displacement towards the core of the nucleus. No large-scale intermixing of the nuclear content with the cytosol was found, although in some sections there were disruptions in the nuclear envelop continuity. The entrance of mitochondria into the nucleus was modeled in rats that were given ethanol and the catalase inhibitor aminotriazole for 12 weeks. It is suggested that the entrance of mitochondria into the nucleus promotes both the attack of mitochondria by nuclear proteins and the attack of nuclear DNA and proteins by proteins of the mitochondrial intermembrane space.  (+info)

Cardiac manifestations of cocaine abuse: a cross-sectional study of asymptomatic men with a history of long-term abuse of "crack" cocaine. (8/44)

OBJECTIVES: The objective of this study was to evaluate the prevalence of cardiac abnormalities in young, asymptomatic long-term "crack" cocaine abusers. BACKGROUND: Although the cardiac complications of cocaine abuse have received widespread attention, the prevalence of cardiac abnormalities in asymptomatic long-term cocaine abusers is unknown. METHODS: History, physical examination, electrocardiogram (ECG) and echocardiogram were performed in 52 consecutive long-term cocaine abusers admitted to a drug rehabilitation program. Findings were compared with those in 14 age-matched normal volunteers and 14 age-matched normotensive patients admitted to a psychiatric service who had a pattern of smoking and alcohol consumption similar to that of the study patients. RESULTS: The ECG findings were abnormal in 29% of cocaine abusers, and included nonspecific ST-T wave changes in 15%, abnormal ST segment elevation in 10%, old inferior infarction in 2%, old anteroseptal infarction in 2% and abnormal precordial R wave progression in 10%. When compared with normal volunteers and control patients, cocaine abusers had increased left ventricular posterior wall thickness (1.12 vs. 0.76 and 0.85 cm, respectively, p < 0.0001), increased septal thickness (1.13 vs. 0.76 and 0.86 cm, p < 0.001) and higher left ventricular mass index (142 vs. 84 and 94 g/m2, p < 0.0001). Left ventricular diastolic filling variables did not differ significantly among the three groups. Diastolic filling variables were similar in cocaine abusers with and without left ventricular hypertrophy, and the prevalence of left ventricular hypertrophy did not differ significantly between those who used no alcohol or < 35 ml/week of alcohol and those who consumed > or = 500 ml/week of alcohol. Left ventricular segmental wall motion abnormalities were present in 11 subjects (21%) and the ejection fraction was decreased (< 0.45) in 2 (4%). CONCLUSIONS: Electrocardiographic and echocardiographic abnormalities are common in long-term cocaine abusers. Despite the frequent occurrence of left ventricular hypertrophy, Doppler-derived diastolic filling pattern was not altered. Concomitant alcohol use did not affect the prevalence of these abnormalities.  (+info)

Medical information, Alcoholic cardiomyopathy. Definition of Alcoholic cardiomyopathy, symptoms of Alcoholic cardiomyopathy, treatment of Alcoholic cardiomyopathy, and prevention of Alcoholic cardiomyopathy. Exams and Tests Alcoholic cardiomyopathy.
Studies have shown that alcohol is easily the most frequently consumed toxic substance, but when its mistreated, it may cause a number of health issues, including alcoholic cardiomyopathy.. Precisely what is alcoholic cardiomyopathy? Well, its a type of cardiovascular disease occurring because of lengthy-term excessive drinking. Doctors have noted for a lengthy time that mistreating alcohol for any lengthy time period can weaken and thin the center muscles, which could change up the hearts capability to pump bloodstream. This inefficient pumping of bloodstream could affect all of your bodys vital functions and result in existence-threatening heart issues.. Alcoholic cardiomyopathy is typical in males between 35 and 50 however, make no mistake, it may also affect women. Individuals who are afflicted by alcoholic cardiomyopathy will often have a lengthy-term good reputation for heavy consuming. With regards to drinking, lengthy-term is understood to be five to fifteen years. Heavy consuming of ...
Another name for Alcoholic Cardiomyopathy is Alcoholic Cardiomyopathy. There is no cure for alcoholic cardiomyopathy, but treatment can control symptoms ...
Alcoholic cardiomyopathy is a type of heart failure thats brought on by long-term alcohol abuse. The main signs of alcoholic...
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Page 2 Ξ Pathophysiology of alcoholism pdf ➥ Pathophysiology of alcoholism withdrawal ➥ Alcoholic liver pathophysiology ➥ Chronic alcoholism pathophysiology ➥ Alcoholism pathophysiology ➥ Geriatric alcoholism pathophysiology and dental implications ➥ Pathophysiology alcoholic liver cirrhosis ➥ Alcoholic cirrhosis pathophysiology ppt ➥ Pathophysiology alcoholic liver disease ➥ Alcoholism pathophysiology ppt Pancreatitis alcoholism pathophysiology Alcoholism anemia pathophysiology Geriatric alcoholism pathophysiology and dental implications Alcoholism hypertension pathophysiology Alcoholism pathophysiology Alcoholic cirrhosis pathophysiology Alcoholic cardiomyopathy pathophysiology Alcoholic cirrhosis pathophysiology pdf Alcoholic cirrhosis pathophysiology ppt Alcoholic cardiomyopathy pathophysiological insights Chronic alcoholism pathophysiology Alcohol use disorder pathophysiology Alcoholic encephalopathy pathophysiology Pathophysiology alcoholic fatty liver Pathophysiology for
Another name for Heart Failure from Alcoholism is Alcoholic Cardiomyopathy. To better understand alcoholic cardiomyopathy, it helps to understand the ...
Grant Support: By grants from Fondo de Investigaciones Sanitarias (FIS 98/0330 and 99/0115) and by Generalitat de Catalunya (CUIR 1999/SGR-279).. Requests for Single Reprints: Emanuel Rubin, MD, Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Suite 279, Philadelphia, PA 19107.. Current Author Addresses: Drs. Nicolás, Fernández-Solà, Estruch, Paré, Sacanella, and Urbano-Márquez: Hospital Clinic, Villarroel, 170, Barcelona, Spain 08036.. Dr. Rubin: Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Suite 279, Philadelphia, PA 19107.. Author Contributions: Conception and design: J.M. Nicolás, J. Fernández-Solà, A. Urbano-Márquez, E. Rubin.. Analysis and interpretation of the data: J.M. Nicolás, J. Fernández-Solà, J.C. Paré, E. Rubin.. Drafting of the article: J.M. Nicolás, J. Fernández-Solà, E. Rubin.. Critical revision of the article for important intellectual content: D. Estruch, E. ...
Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, alcoholic cardiomyopathy, and muscle damage. Further, we have reviewed the role of altered microRNAs in the circulation, teratogenic effects of alcohol, and during maternal or paternal alcohol consumption.
METHODS AND FINDINGS: We collected and harmonized data on mortality from four alcohol-related causes (alcoholic psychosis, dependence, and abuse; alcoholic cardiomyopathy; alcoholic liver cirrhosis; and accidental poisoning by alcohol) by age, sex, education level, and occupational class in 20 European populations from 17 different countries, both for a recent period and for previous points in time, using data from mortality registers. Mortality was age-standardized using the European Standard Population, and measures for both relative and absolute inequality between low and high socioeconomic groups (as measured by educational level and occupational class) were calculated. Rates of alcohol-related mortality are higher in lower educational and occupational groups in all countries. Both relative and absolute inequalities are largest in Eastern Europe, and Finland and Denmark also have very large absolute inequalities in alcohol-related mortality. For example, for educational inequality among ...
Dow Breweries was a brewing company based in the province of Quebec, Canada. The company was founded in Montreal by William Dow (1800-1868). Its brewery in Quebec City was formed in 1952 in the facilities formerly used by the Boswell Brewery (1843-1952). It was acquired by Carling OKeefe and stopped its activities on March 31, 1966. After the purchase by Carling OKeefe, the Dow brand came under the ownership of Molson, but disappeared from the Canadian market in the spring of 1997. Brands brewed by Dow included Dow Ale, Kingsbeer Lager and Black Horse Ale. At the urging of Board chair and academic Pierre Gendron, Dow Breweries supported the construction of the Montreal Planetarium, originally calling it "Dow Planetarium". It was completed in 1966 as one of many projects for the Canadian Centennial. In August 1965, a patient presented to a hospital in Quebec City with symptoms suggestive of alcoholic cardiomyopathy. Over the next 8 months 50 more cases with similar findings appeared in the same ...
One hundred and forty-five alcoholics without known causes of heart disease, who were serially admitted to the alcohol detoxification centre, were studied to see the incidence of cardiac abnormalities and dose related effects of ethanol. All patients were divided into heavy (consumed more than the equivalent amount of 125 ml of pure ethanol daily for 10 years or more) and moderate drinkers (consumed 75 to 125 ml of ethanol daily). All of them were ambulatory and free from cardiac symptoms. There was no difference among heavy and moderate drinkers in the incidence of abnormalities detected by the electrocardiograms and chest x-ray films. In the alcoholics, the most frequent finding was a prolonged QTc interval of more than 0.44 s on the electrocardiogram (62 patients, 42.8%), unrelated to serum electrolytes imbalance. Cardiomegaly on chest x-ray film was observed in 25 patients (17.2%). M-mode echocardiogram was recorded in randomly selected patients and compared with age and sex matched ...
High-dose alcohol misuse induces multiple noxious cardiac effects, including myocyte hypertrophy and necrosis, interstitial fibrosis, decreased ventricular contraction and ventricle enlargement. These effects produce diastolic and systolic ventricular dysfunction leading to congestive heart failure, arrhythmias and an increased death rate. There are multiple, dose-dependent, synchronic and synergistic mechanisms of alcohol-induced cardiac damage. Ethanol alters membrane permeability and composition, interferes with receptors and intracellular transients, induces oxidative, metabolic and energy damage, decreases protein synthesis, excitation-contraction coupling and increases cell apoptosis. In addition, ethanol decreases myocyte protective and repair mechanisms and their regeneration. Although there are diverse different strategies to directly target alcohol-induced heart damage, they are partially effective, and can only be used as support medication in a multidisciplinary approach. Alcohol abstinence
Chronic alcohol exposure affects the central nervous system, influences behavior, and induces neuroadaptive changes in vertebrate species including our own. literature to be alcohol related. We conclude that the zebrafish is an excellent tool for the analysis of genes associated with alcohols actions in vertebrates, one which may facilitate the discovery and better understanding of […]. ...
Naruto froze mid-Shunpo as he felt Renjis reiatsu begin to rapidly diminish. Renji… I guess it all depends on Ichigo now… he bit his cheek. He hadnt expected Renji to best Byakuya, but he knew that Renji at least stood a fair chance of inflicting a wound. He knew of his feelings towards Byakuya, and he knew that this duel would better the camaraderie between the two Shinigami. He turned to the other direction as he felt a different reiatsu. Thats Kenpachi-taicho… Tosen-taicho? Komamura-taicho? Whats going on? Why are they fighting? after a moment, he shrugged. Well, I guess thats just two less captains to deal with. he took off again, racing towards the Sokyoku.. With Renji. It was a truly wondrous sight. Thousands of razor-sharp blade shards danced like petals in the air, their beauty hiding their lethality. The scene they created, however, was much less majestic. Renji laid in a pool of his blood, the shattered remnants of his Bankai scattered around him. He futilely held onto ...
Chronic alcohol exposure affects the central nervous system, influences behavior, and induces neuroadaptive changes in vertebrate species including our own. literature to be alcohol related. We conclude that the zebrafish is an excellent tool for the analysis of genes associated with alcohols actions in vertebrates, one which may facilitate the discovery and better understanding of […]. ...
Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month...
If you suspect Beriberi then treat it! Diagnosis is clinical and difficult to confirm, treatment is simple/inexpensive/effective, there is little risk to treatment, and the risk of morbidity/mortality from not treating is high. ...
Las 100 grandes canciones para brillar hebilla. Todos las hemos bailado alguna vez, así sea en diciembre, o en las fiestas de los abuelos. Este no es propiamente pa brillar hebilla, pero aguanta ...
Abstract:The Asia Pacific Beriberi soap market size is $XX million USD in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million USD by.
C-vitamiini õige manustamine võib ravi ühe osana olla efektiivne nt alkoholismi, artriidi, beriberi, gripi, seljavalude, hammaste ja igemete haiguste, diabeedi, stenokardia jne puhul. C-vitamiini on kasulik manustada koos foolhappe, püridoksiini, niatsiini, B1, B2, bioflavonoidide, E-vitamiini, kaltsiumi ja magneesiumiga. See komplekt tagab optimaalse mõju omavahel seotud bioloogilistele protsessidele. Suuremate annuste puhul tuleb silmas pidada, et C-vitamiini rasvlahustuvad vormid imenduvad paremini. Päevaseks ohutuks koguseks korduval manustamisel on sätestatud 1000 mg (kõhulahtisuse riski vältimiseks), ühekordset ohutut annust pole sätestatud. Väga suurtes kogustes C-vitamiini tarbimine võib põhjustada kõhukrampe, iiveldust, kõhulahtisust ning on vastunäidustatud neerupuudulikkuse, pidevalt hemodialüüsi saavatel haigetel ning raua omastamisega seotud haigusseisundite korral. On oletatud, et pidev megaannuste tarbimine võib kahjustada neere ning soodustada neerukivide ...
To assess the role of acute alcohol ingestion as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. Paired Mantel-Haenszel analysis revealed that alcohol ingestion within 24 (p = 0.07) and 72 (p = 0.001) hours of stroke onset and medical histories of smoking (p less than 0.0001), hypertension (p less than 0.001), and transient ischemic attacks (p = 0.051) were more common among stroke index cases than controls. Matched multiple logistic analysis revealed that both hypertension (p less than 0.05) and smoking (p less than 0.05) were independently associated with stroke, while alcohol consumption was not. In analyses to assess the possibility of mutual confounding effects of independent variables, the effect of alcohol ingestion was lost when adjusting for smoking. We conclude that acute alcohol ingestion is not an ...
Beriberi, white rice, and vitamin B by Kenneth J. Carpenter; 4 editions; First published in 2000; Subjects: Adverse effects, Beri-beri, Beriberi, Etiology, History, Oryza sativa, Rice, Therapeutic use, Thiamine, Thiamine Deficiency, Vitamin B1
Looking for online definition of Ehlers-Danlos-like syndrome due to tenascin-X deficiency in the Medical Dictionary? Ehlers-Danlos-like syndrome due to tenascin-X deficiency explanation free. What is Ehlers-Danlos-like syndrome due to tenascin-X deficiency? Meaning of Ehlers-Danlos-like syndrome due to tenascin-X deficiency medical term. What does Ehlers-Danlos-like syndrome due to tenascin-X deficiency mean?
A review article published online in Behavioral Brain Research provides novel insight into changes that happen in the brain as a result of chronic alcohol exposure that can lead to disruptions in the sleep cycle.
1. Chronic consumption of alcohol has a very negative effect on the human body. Not only does it impair your judgment, but it is also very harmful to the organs in your body. When someone consumes more than enough alcohol, it tends to lead to Brain, Li...
Alcoholism takes a toll on every aspect of a persons life, including skin problems. Now, a new research report appearing in the April 2015 issue of the Journal of Leukocyte ...
Beriberi is caused by a lack of thiamine, or vitamin B1. Thiamine deficiency is rare in developed countries, but it still occurs...
A new study by MU School of Medicine researchers shows that chronic alcohol use, when combined with repeated binge drinking, causes more damage to the liver than previously thought.
Depend on body weight, tolerance, and amount and time period of alcohol ingestion; full absorption may not occur until 6h after ingestion ...
Beriberi, ailment caused by a deficiency of vitamin B1 (thiamine), the symptoms of which may include weight loss, emotional disturbances, impaired sensory perception, weakness, and periods of irregular heartbeat. Beriberi, Microsoft® Encarta® Encyclopedia 2000. © 1993-1999 Microsoft Corporation. All rights reserved.
Beriberi disease is due to vitamin B1 (thiamine) deficiency. It manifests as neurological disorders, peripheral paralysis, psychosis, weakened heart and impaired circulatory system and results in heart failure and death.
Beriberi is one of the most destructive vitamin deficiency diseases, especially in cases of prolonged lack of thiamine in the diet. Initial symptoms include
It is very unusual to have pain in the liver area because of HCV. When this happens it is usually because enlargement of the liver secondary to fat deposition, as can be seen in diabetes, alcohol ingestion, obesity etc. Another cause for pain can be a tumor of the liver, seen in cases with advanced liver disease, and cirrhosis. Most frequently patients think that all they feel in the abdomen area is caused by the HCV, and the majority of times symptoms are caused by the rest of the gastrointestinal tract ...
2. Fanel seeds : Make a paste by grinding small fennel and apply it on the affected part, it ends swelling of the hand and feet.. 3. Cactus root: Make a paste by grinding cactus root with rosewater. Apply this paste on the affected part; it is useful to end swelling of the hand and feet.. 4. Flavieria repanda: Make a powder by grinding seeds of flavieria repanda and toast it with ghee. Take 1.5 grams to 3 grams this powder twice a day to get relief in beriberi. This medicine is very useful to cure beriberi.. 5. Garlic: Mix 10-30 drops juice of garlic with milk and take it 2-3 times in a day, it provides relief in beriberi.. 6. Himalayan cedar: Take 3-6 grams powder of Himalayan cedar twice a day, it is useful to end body swelling.. 7. Gmelina arborea: Take 20-40 ml decoction of ground root of gmelina arborea twice a day regularly, it is useful to end feet swelling.. 8. Potato: Take one spoon potato juice twice a day regularly, it is useful to cure beriberi.. 9. Orange: Take orange juice, it is ...
Puerarin is an isoflavone component extracted from Kudzu (Pueraria lobata) and has been demonstrated to alleviate alcohol-related disorder. The purpose of this study was to examine whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotxin gut-leakage, the subsequent Kupffer cells (KCs) activation and lipopolysaccharide (LPS) receptors expression. Rats were provided with the Liber-DeCarli liquid diet for eight weeks. Puerarin (90 mg and 180 mg/kg.d) was orally administered from the beginning of the third week till the end of the experiment. Chronic alcohol intake caused increased serum ALT, AST, hepatic GGT and TG levels as well as fatty liver and neutrophil infiltration in hepatic lobules determined by biochemical and histological assay. A significant increase of liver tumor necrosis factor α (TNF-α) was detected by enzyme-linked immunosorbent assay. These pathological effects correlated with increased endotoxin level in portal vein and up-regulated protein ...
Introduction: Extracorporeal Membrane Oxygenation (ECMO) serves as a mechanical circulatory support bridge to recovery in children, allowing the heart to overcome severe insults such as ischemia/reperfusion injury. ECMO unloads the left ventricle, decreasing contractile work and oxygen consumption. Decreased loading can induce myocardial atrophy, which may affect recovery of function. The mechanisms leading to myocardial atrophy and dysfunction are unclear, but may relate to alterations in protein synthesis or degradation with increases in amino acid (AA) oxidation.. Hypothesis: We tested the hypothesis that ventricular unloading (ECMO) increases AA contribution to oxidative flux while decreasing AA protein incorporation.. Methods: We placed immature swine (7.8-14.5 kg, n=16) under general anesthesia and provided intracoronary infusion of 13C6, 15N L-leucine alone or with sodium 2-13C pyruvate after 8 hours of loaded (LOAD) or ECMO conditions (arterial pulse pressure: 26 ± 2.3 mmHg vs. 6 ± 1.1 ...
Meddyg nodedig o Japan oedd Takaki Kanehiro (30 Hydref 1849 - 13 Ebrill 1920). Meddyg llyngesol Japaneaidd ydoedd. Ym 1905, cafodd ei anrhydeddu ar teitl danshaku (barwn) am ei gyfraniadau ynghylch dileu beriberi o Lynges Imperialaidd Japan, dyfarnwyd iddo hefyd yr Order of the Rising Sun (dosbarth cyntaf). Cafodd ei eni yn Hyūga Talaith, Japan ac addysgwyd ef yn Ysgol Feddygol Ysbyty St Thomas. Bu farw yn Tokyo. ...
Separately, chronic alcohol ingestion and HIV-1 infection are associated with severe skeletal muscle derangements, including atrophy and wasting, weakness, and fatigue. One prospective cohort study reported that 41% of HIV-infected patients met the criteria for alcoholism, however; few reports exist on the co-morbid effects of these two disease processes on skeletal muscle homeostasis. Thus, we analyzed the atrophic effects of chronic alcohol ingestion in HIV-1 transgenic rats and identified alterations to several catabolic and anabolic factors. Relative plantaris mass, total protein content, and fiber cross-sectional area were reduced in each experimental group compared to healthy, control-fed rats. Alcohol abuse further reduced plantaris fiber area in HIV-1 transgenic rats. Consistent with previous reports, gene levels of myostatin and its receptor activin IIB were not increased in HIV-1 transgenic rat muscle. However, myostatin and activin IIB were induced in healthy and HIV-1 transgenic rats fed
Although alcoholism and depression are highly comorbid, treatment options that take this into account are lacking, and mouse models of alcohol (ethanol (EtOH)) intake-induced depressive-like behavior have not been well established. Recent studies utilizing contingent EtOH administration through prolonged two-bottle choice access have demonstrated depression-like behavior following EtOH abstinence in singly housed female C57BL/6J mice. In the present study, we found that depression-like behavior in the forced swim test (FST) is revealed only after a protracted (2 weeks), but not acute (24 h), abstinence period. No effect on anxiety-like behavior in the EPM was observed. Further, we found that, once established, the affective disturbance is long-lasting, as we observed significantly enhanced latencies to approach food even 35 days after ethanol withdrawal in the novelty-suppressed feeding test (NSFT). We were able to reverse affective disturbances measured in the NSFT following EtOH abstinence ...
Two-dimensional gels offer a powerful method for separating complex protein mixtures, but subsequent methods for analysing individual components, such as protein sequencing and Western immunoblotting, are laborious and slow. The identification of proteins can be accelerated by using a combination of protease digestion and matrix assisted laser desorption-mass spectrometry (MALDI-MS). The peptide mass spectrum of a protein represents a unique fingerprint determined by the amino acid sequence and the cleavage properties of the protease. Software has been developed so that peptide masses can be used to search a mass-based peptide database generated from established protein sequence databases. A list of the closest matching proteins is produced to allow identification of the sample. The strategy was applied to 52 protein spots from human myocardial tissue separated by two-dimensional electrophoresis (2-DE) gels and analysed blind. Conditions for optimal trypsin digestion of proteins electroblotted ...
the disease beriberi that results from a dietary deficiency of vitamin b1 thiamine is characterized by the neurological, Hire Biology Expert, Ask Academics Expert, Assignment Help, Homework Help, Textbooks Solutions
cardiomyopathy - MedHelps cardiomyopathy Center for Information, Symptoms, Resources, Treatments and Tools for cardiomyopathy. Find cardiomyopathy information, treatments for cardiomyopathy and cardiomyopathy symptoms.
Cardiomyopathy is a set of heart conditions. Treatment of cardiomyopathy includes treating the causes of the condition and treating the disorders brought on by cardiomyopathy.
Alcohol-induced hypertension information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
The ALLMedicine™ Cardiomyopathy Center contains research, news, guidelines, drugs, clinical trials, and patient ed. Information related to Cardiomyopathy. Browse Now!
How is cardiomyopathy diagnosed? In some cases, cardiomyopathy does not have any presenting symptoms, particularly in the early stages. This is because the hear
Has your dog recently been diagnosed with Dilated Cardiomyopathy? Learn more about the causes and treatment methods for Dilated Cardiomyopathy in dogs.
The ACM India Council is an effort of ACM aimed at increasing the level and visibility of ACM activities across India. The ACM community in India is growing in membership, number of chapters, sponsored conferences and symposia.. The ACM India Council comprises a cross section of the computer science and information technology community committed to increasing the visibility and relevance of ACM in India. The council is focused on a wide range of ACM activities including:. ...
Puerperal cardiomyopathy information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
Inquire for Dilated Cardiomyopathy Therapeutics Market 2017 Competitive Analysis, Trends and Forecast till 2022, with free sample copy of the report.
Alcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the rewarding effects of alcohol, dopaminergic ventral tegmental area (VTA) projections to the nucleus accumbens (NAc) have been identified. Acute exposure to alcohol stimulates dopamine release into the NAc, which activates D1 receptors, stimulating PKA signaling and subsequent CREB-mediated gene expression, whereas chronic alcohol exposure leads to an adaptive downregulation of this pathway, in particular of CREB function. The decreased CREB function in the NAc may promote the intake of drugs of abuse to achieve an increase in reward and thus may be involved in the regulation of positive affective states of addiction. PKA signaling also affects NMDA receptor activity and may play an important role in neuroadaptation in response to chronic alcohol exposure ...
Alcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the rewarding effects of alcohol, dopaminergic ventral tegmental area (VTA) projections to the nucleus accumbens (NAc) have been identified. Acute exposure to alcohol stimulates dopamine release into the NAc, which activates D1 receptors, stimulating PKA signaling and subsequent CREB-mediated gene expression, whereas chronic alcohol exposure leads to an adaptive downregulation of this pathway, in particular of CREB function. The decreased CREB function in the NAc may promote the intake of drugs of abuse to achieve an increase in reward and thus may be involved in the regulation of positive affective states of addiction. PKA signaling also affects NMDA receptor activity and may play an important role in neuroadaptation in response to chronic alcohol exposure ...
The effects of chronic alcohol intake on menstrual cycle status and hormonal function were studied in 26 healthy, adult women under controlled research ward conditions. Women were classified as heavy, social or occasional alcohol users on the basis of the actual number of drinks consumed during 3 consecutive weeks of alcohol availability. Heavy, social and occasional users drank an average of 7.81 ( +/- 0.69), 3.84 ( +/- 0.19) and 1.22 ( +/- 0.21) drinks/day, respectively. This drinking pattern was highly consistent with subjects self-reports of alcohol use before the study. No evidence of menstrual cycle dysfunction or abnormality in reproductive hormone levels was found in the occasional drinkers or in two of the social drinkers who consumed less than an average of three drinks/day. In contrast, 50% of the social drinkers who consumed more than three drinks/day and 60% of the heavy drinkers had significant derangements of menstrual cycle and reproductive hormone function. The major ...
The purpose of this study was to determine the effects of a combined antioxidant supplementation on myocardial protein carbonyls (PC) and malondialdehyde (MDA) in rats after aerobic downhill running. Sixty-six male Sprague-Dawley rats were randomly ...
In this study, we demonstrate that sodium deprivation in rats causes alterations in cardiac βAR affinity responsiveness assessed by adenylyl cyclase activity. Our data indicate that a primary mechanism is the reduction of the percentage of βARs in the high affinity conformation caused by the increased expression and activity of cardiac βARK1. Interestingly, atenolol treatment prevented the rise in βARK1 levels in the heart and improved βAR signaling.. The pivotal role of βARK1 in cardiac βAR signaling and function was first shown in transgenic mice with cardiac overexpression of this GRK.24 In that study it was shown for the first time that this regulator of βAR signaling was able (in absence of other alterations of the excitation-contractile machinery of the heart) to dampen the cardiac contractile response to βAR stimulation.24 After this initial study, many observational studies have associated increased cardiac βARK1 levels to animal and human models of cardiac dysfunction.5-10 ...
Caring - We are devoted to supporting those affected by cardiomyopathy. Dedicated - We are committed to giving information, advice & support across the UK. Responsive - We reach out to anyone who needs us. Collaborative - We work with others to benefit those affected by cardiomyopathy. Expert - We provide up to date specialist knowledge about cardiomyopathy. Realistic - We are always honest and realistic about cardiomyopathy and the impact it can have. ...
Do You Have Dilated Cardiomyopathy? Join friendly people sharing 39 true stories in the I Have Dilated Cardiomyopathy group. Find support forums, advice and chat with groups who share this life experience. A Dilated Cardiomyopathy anonymous support g...
The global cardiomyopathy medication market is expected to reach $ 1148.9 mn by the year 2026, at a CAGR of 2.1%. cardiomyopathy is an ailment of the heart muscle that makes it difficult for ones heart to pump blood to the other parts of the body.
Viral cardiomyopathy is a heart condition caused by a viral infection. Though viral cardiomyopathy can be treated, it can cause...
The Cardiomyopathy information page was created to share information about genetic heart disease and the incidence of cardio in Scottish Folds.
Alcoholic enabler is an individual who by means of their actions make it easy for an addict to go on with their self destructive attitude by rescuing or
Cardiomyopathy is a condition which makes it harder for the heart to pump and supply blood to the other parts of the body. Know its causes, symptoms, treatment.
So many people ask the question, what are the signs of an alcoholic and many people really dont know the answer and why is that? The reason they dont know the answer is because they are not one.
How many of the Omnium should I take? 1 or 2 pills. I dont take anything to thin my blood so I suppose it will be OK to take this ...
It is so good to hear from you. Thank you for continuing to keep this Forum available. It truly means a lot to so many.I hope all is well for you, and your loved ones ...
Alcoholic cardiomyopathy. *Alcohol flush reaction (AFR). Gastrointestinal diseases. *Alcoholic liver disease (ALD): *Alcoholic ...
Large amount of alcohol over the long term can lead to alcoholic cardiomyopathy. Alcoholic cardiomyopathy presents in a manner ... 2010). "Alcoholic and cocaine-associated cardiomyopathies". Prog Cardiovasc Dis. 52 (4): 289-99. doi:10.1016/j.pcad.2009.11.004 ... 2. Alcoholic dementia or alcoholic cognitive impairment?". Psychol Neuropsychiatr Vieil (in French). 1 (4): 237-49. PMID ... "There is sufficient evidence for the carcinogenicity of alcoholic beverages in humans.... Alcoholic beverages are carcinogenic ...
In August 1965, a patient presented to a hospital in Quebec City with symptoms suggestive of alcoholic cardiomyopathy. Over the ... Morin Y, Tětu A, Mercier G (1969). "Quebec beer-drinkers' cardiomyopathy: Clinical and hemodynamic aspects]". Ann N Y Acad Sci ... cardiomyopathy: forty-eight cases". Canadian Medical Association Journal. 97: 881-883. PMC 1923396 . PMID 6051256. ...
In August 1965, a patient presented to a hospital in Quebec City with symptoms suggestive of alcoholic cardiomyopathy. Over the ... Morin Y, Tětu A, Mercier G (1969). "Quebec beer-drinkers' cardiomyopathy: Clinical and hemodynamic aspects]". Ann N Y Acad Sci ... Y. L. Morin; A. R. Foley; G. Martineau; J. Roussel (1967). "Quebec beer-drinkers' cardiomyopathy: forty-eight cases". Canadian ...
His unsuccessful struggle with his addiction caused his death on 19 July 2013 of heart failure due to alcoholic cardiomyopathy ... With Korol i Shut: Solo albums: 2005 - I'm Alcoholic Anarchist ("Я алкоголик-анархист") Mikhail Gorshenyov at Find a Grave ...
Alcoholic cardiomyopathy (425.7) Nutritional and metabolic cardiomyopathy (425.8) Cardiomyopathy in other diseases classified ... Cardiomyopathy (425.0) Endomyocardial fibrosis (425.1) Hypertrophic obstructive cardiomyopathy (425.2) Obscure cardiomyopathy ... elsewhere (425.9) Secondary cardiomyopathy unspecified (426) Conduction disorders (426.0) Atrioventricular block, third degree ... of africa (425.3) Endocardial fibroelastosis (425.4) Other primary cardiomyopathies (425.5) ...
Alcoholic cardiomyopathy (I42.8) Other cardiomyopathies Arrhythmogenic right ventricular dysplasia (I43) Cardiomyopathy in ... Cardiomyopathy (I42.0) Dilated cardiomyopathy (I42.1) Obstructive hypertrophy cardiomyopathy (I42.2) Other hypertrophic ... Ischaemic cardiomyopathy (I25.6) Silent myocardial ischaemia (I25.8) Other forms of chronic ischaemic heart disease (I25.9) ... cardiomyopathy (I42.3) Endomyocardial (eosinophilic) disease Eosinophilic myocarditis Endomyocardial (tropical) fibrosis ...
... alcoholic hepatitis, alcoholic liver disease, alcoholic cardiomyopathy.) Substance abuse is also often associated with ...
... alcoholic neuropathy MeSH C21.739.100.087.250 --- cardiomyopathy, alcoholic MeSH C21.739.100.087.397 --- fetal alcohol syndrome ... alcoholic MeSH C21.739.100.087.645.490 --- hepatitis, alcoholic MeSH C21.739.100.087.645.550 --- liver cirrhosis, alcoholic ... alcoholic MeSH C21.739.100.175 --- alcoholic intoxication MeSH C21.739.100.250 --- alcoholism MeSH C21.739.100.625 --- wernicke ... alcoholic neuropathy MeSH C21.613.705.200 --- dyskinesia, drug-induced MeSH C21.613.705.400 --- mptp poisoning MeSH C21.613. ...
... cardiomyopathy, alcoholic MeSH C14.280.238.070 --- cardiomyopathy, dilated MeSH C14.280.238.100 --- cardiomyopathy, ... cardiomyopathy, restrictive MeSH C14.280.238.190 --- chagas cardiomyopathy MeSH C14.280.238.281 --- endocardial fibroelastosis ... cardiomyopathy, dilated MeSH C14.280.434.313 --- dyspnea, paroxysmal MeSH C14.280.434.482 --- edema, cardiac MeSH C14.280. ... cardiomyopathy, dilated MeSH C14.280.195.400 --- hypertrophy, left ventricular MeSH C14.280.195.410 --- hypertrophy, right ...
... is a type of dilated cardiomyopathy. Due to the direct toxic effects of alcohol on heart muscle, the ... Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol) leads to heart failure. ... Treatment for alcoholic cardiomyopathy involves lifestyle changes, including complete abstinence from alcohol use, a low sodium ... Signs and symptoms presented by the occurrence of alcoholic cardiomyopathy are the result of the heart failing and usually ...
Alcohol abuse (alcoholic cardiomyopathy) Nonalcoholic toxic insults include administration of certain chemotherapeutic agents, ... Cardiomyopathy - Stanford Children's Health Cardiomyopathy Association: Dilated cardiomyopathy Children's Cardiomyopathy ... Dilated cardiomyopathy occurs late in gestation or several weeks to months postpartum as a peripartum cardiomyopathy. It is ... "What Is Cardiomyopathy?". NHLBI. 22 June 2016. Retrieved 10 November 2017. "Types of Cardiomyopathy". NHLBI. 22 June 2016. ...
Alcoholic hallucinosis Korsakoff's syndrome (F11) use of opioids Opioid overdose Opioid dependency ...
Difference between alcoholic and nonalcoholic subjects". The New England Journal of Medicine. 292 (8): 386-9. doi:10.1056/ ... Pawan GL (May 1973). "Alcoholic drinks and hangover effects". The Proceedings of the Nutrition Society. 32 (1): 15A. PMID ... Beverage-specific effects of additives or by-products such as congeners in alcoholic beverages also play an important role.[1] ... Social drinkers and alcoholics claim that drinking more alcohol gives relief from hangover symptoms, but research shows that ...
Alcoholic cardiomyopathy. *Alcohol flush reaction. SUD. *Alcoholism (alcohol use disorder). *Binge drinking ...
In the Qur'an,[54][55][56] there is a prohibition on the consumption of grape-based alcoholic beverages, and intoxication is ... Alcohol intoxication typically begins after two or more alcoholic drinks.[4] Risk factors include a social situation where ... Ruminant farm animals have natural fermentation occurring in their stomach, and adding alcoholic beverages in small amounts to ... sudden lapses into and out of unconsciousness or semi-consciousness (with later alcoholic amnesia) ...
Alcoholic cardiomyopathy. *Alcohol flush reaction. SUD. *Alcoholism (alcohol use disorder). *Binge drinking ...
Alcoholic cardiomyopathy. *Alcohol flush reaction. SUD. *Alcoholism (alcohol use disorder). *Binge drinking ...
Alcoholic cardiomyopathy. *Alcohol flush reaction. Gastrointestinal diseases. *Alcoholic liver disease: *Alcoholic hepatitis ... As many as 30-50% of alcoholics are also benzodiazepine misusers.[14] Drug abusers often abuse high doses which makes serious ... alcoholics or amphetamine addicts when "coming down".[21] but sometimes are misused in isolation as the primary drug of misuse ... "Liability to alprazolam abuse in daughters of alcoholics". The American Journal of Psychiatry. 153 (7): 956-958. doi:10.1176/ ...
Di Rocco M, Patrini C, Rimini A, Rindi G. A 6-month-old girl with cardiomyopathy who nearly died. Lancet. 1997;349(9052):616 ... Benfotiamine efficacy in alcoholic polyneuropathy therapy] Zh Nevrol Psikhiatr Im S S Korsakova. 2001;101(12):32-6. Russian ... Woelk H, Lehrl S, Bitsch R, Kopcke W. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled ... upregulation contribute to the onset of diabetic cardiomyopathy. J Cell Mol Med. 2008 Oct 13. Abstract ...
Alcoholics may have thiamine deficiency because of the following: *Inadequate nutritional intake: Alcoholics tend to intake ... Dilated cardiomyopathy. Gastrointestinal beriberi[edit]. Gastrointestinal beriberi causes abdominal pain. Gastrointestinal ...
The cause of death was ventricular fibrillation triggered by cardiomyopathy. Before he died, Würzel was working on new material ... a rehabilitation centre for drug addicts and alcoholics) Atomgods - WOW! (1988) Warhead - Warhead (1995) Disgust - A World Of ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Tachycardia-induced. *Restrictive. *Loeffler endocarditis. *Cardiac ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis. *Endocardial ...
Cardiomyopathy *Dilated *Alcoholic. *Hypertrophic. *Restrictive. *Loeffler endocarditis. *Cardiac amyloidosis. *Endocardial ...
Tinctures are alcoholic extracts of herbs, which are generally stronger than herbal teas.[34] Tinctures are usually obtained by ... Current research focuses on the possibility that this plant also protects gorillas from fibrosing cardiomyopathy, which has a ... Herbal wine and elixirs are alcoholic extract of herbs, usually with an ethanol percentage of 12-38%.[33] Extracts include ...
Alcoholic cardiomyopathy is a type of heart failure thats brought on by long-term alcohol abuse. The main signs of alcoholic ... Alcoholic cardiomyopathy is a form of heart failure that is brought on by long term abuse of alcohol. Also referred to as ... Damage to the heart muscle, or alcoholic cardiomyopathy, may occur in a patient with a long term pattern of consuming seven to ... Several tests may be done to diagnose alcoholic cardiomyopathy. The physician may order a chest X-ray which would show that the ...
There is no cure for alcoholic cardiomyopathy, but treatment can control symptoms ... ... Another name for Alcoholic Cardiomyopathy is Alcoholic Cardiomyopathy. ... Alcoholic Cardiomyopathy Low Sodium Diet. A person with alcoholic cardiomyopathy may benefit from a low sodium diet.. Increased ... Alcoholic Cardiomyopathy Treatment. There is no cure for alcoholic cardiomyopathy, but treatment can control symptoms and ...
Definition of Alcoholic cardiomyopathy, symptoms of Alcoholic cardiomyopathy, treatment of Alcoholic cardiomyopathy, and ... prevention of Alcoholic cardiomyopathy. Exams and Tests Alcoholic cardiomyopathy. ... Alcoholic cardiomyopathy. Definition. Alcoholic cardiomyopathy is a disorder in which excessive, habitual use of alcohol ... Cardiomyopathy - alcoholic Causes. Drinking alcohol in large quantities has a toxic effect on heart muscle cells. Alcoholic ...
Symptoms of alcoholic neuropathy, like those of many of the other axonal mixed polyneuropathies, manifest initially in the ... Diseases & Conditions Alcoholic Cardiomyopathy * 2010 octacosyl-alcohol-octacosanol-344625 Drugs Drugs octacosanol ... encoded search term (Alcoholic Neuropathy) and Alcoholic Neuropathy What to Read Next on Medscape. Related Conditions and ... Most patients diagnosed with alcoholic neuropathy are aged 40-60 years. As mentioned previously, development of alcoholic ...
Alcoholic cardiomyopathy recovery can be difficult. Combined with the strategy to alcoholic cardiomyopathy, it is vital that ... Prognosis of alcoholic cardiomyopathy. Alcoholic cardiomyopathy prognosis depends upon just how much alcohol continues to be ... How you can treat alcoholic cardiomyopathy. Theres no quick cure. Alcoholic cardiomyopathy treatment concentrates on ... Existence expectancy and recovery of alcoholic cardiomyopathy. People frequently inquire about alcoholic cardiomyopathy ...
Alcoholic cardiomyopathy. * Alcoholic liver disease * Alcoholic neuropathy *Blood clotting disorders. * Wernicke-Korsakoff ... Support groups (such as Alcoholics Anonymous). The patient should be tested, and if necessary, treated for other medical ...
What is alcoholic polyneuropathy? Meaning of alcoholic polyneuropathy medical term. What does alcoholic polyneuropathy mean? ... Looking for online definition of alcoholic polyneuropathy in the Medical Dictionary? alcoholic polyneuropathy explanation free ... 117 533 Alcohol Abuse 70 21 91 Epilepsy 21 16 37 Alcoholic Polyneuropathy 0 0 0 Hypertension 23 7 30 Alcoholic Cardiomyopathy ... 1,966 1,163 3,129 Epilepsy 655 569 1,224 Alcoholic Polyneuropathy 41 131 54 Hypertension 329 1341 462 Alcoholic Cardiomyopathy ...
Excessive use of alcohol has a direct toxic effect on the heart muscle cells. The heart muscle becomes weakened and cannot pump blood efficiently. The lack of blood flow affects all parts of the body,
Alcoholic Cardiomyopathy. Topic Overview. Alcoholic cardiomyopathy is caused by long-term alcohol abuse. It is a type of ... Continued alcohol consumption, on the other hand, will continue to make alcoholic cardiomyopathy worse. Treatment includes ... 2011). Dilated cardiomyopathies. In V Fuster et al., eds., Hursts the Heart, 13th ed., vol. 1, pp. 821-836. New York: McGraw- ... Muscular weakness may also be present because of the effect of alcohol on muscles (alcoholic myopathy). ...
Alcoholic cardiomyopathy is a type of dilated cardiomyopathy. Due to the direct toxic effects of alcohol on heart muscle, the ... Alcoholic cardiomyopathy is a disease in which the chronic long-term abuse of alcohol (i.e., ethanol) leads to heart failure. ... Treatment for alcoholic cardiomyopathy involves lifestyle changes, including complete abstinence from alcohol use, a low sodium ... Signs and symptoms presented by the occurrence of alcoholic cardiomyopathy are the result of the heart failing and usually ...
... review is on the effects of alcohol on the myocardium and its role as a cause of heart failure due to dilated cardiomyopathy ( ... encoded search term (Alcoholic Cardiomyopathy) and Alcoholic Cardiomyopathy What to Read Next on Medscape. Related Conditions ... Alcoholic cardiomyopathy is a disease that primarily affects persons of at least middle age and is observed less commonly in ... Alcoholic cardiomyopathy and cirrhosis. For many years, people who abused alcohol and had cirrhosis were believed to be spared ...
... Subscriber Sign In VisualDx Mobile Feedback Select Language Share Get VisualDx Mobile. There are ... I42.6 - Alcoholic cardiomyopathy. SNOMEDCT:. 83521008 - Dilated cardiomyopathy secondary to alcohol. Differential Diagnosis & ... Symptoms (dyspnea with exercise, orthopnea, and paroxysmal nocturnal dyspnea) are those of dilated cardiomyopathy and LV ...
Alcoholic patients with cardiomyopathy had less muscle strength than did alcoholic patients with normal cardiac function, ... The Relation of Alcoholic Myopathy to Cardiomyopathy Joaquim Fernandez-Sola, MD; Ramon Estruch, MD; Josep M. Grau, MD; Joan ... Fernandez-Sola J, Estruch R, Grau JM, Pare JC, Rubin E, Urbano-Marquez A. The Relation of Alcoholic Myopathy to Cardiomyopathy ... Among alcoholic patients with cardiomyopathy, 20 of 24 (83%) had histologic findings of skeletal myopathy compared with 1 of 24 ...
55 alcoholic men with cardiomyopathy who had been drinking a minimum of 100 g of ethanol per day for at least 10 years. ... In patients with alcoholic cardiomyopathy, both abstinence and controlled drinking of up to 60 g of ethanol per day (four ... Cardiomyopathy is a potentially fatal complication of alcohol abuse. In alcoholic persons who develop cardiac dysfunction, ... The Effect of Controlled Drinking in Alcoholic Cardiomyopathy Josep María Nicolás, MD; Joaquim Fernández-Solà, MD; Ramon ...
Patients with alcoholic cardiomyopathy (ACM) have more variants in dilated cardiomyopathy (DCM)-associated genes than those ... More Variants in DCM-Tied Genes in Alcoholic Cardiomyopathy. May 17, 2018 , HealthDay , 0 , ... James S. Ware, M.B.B.S., Ph.D., from Imperial College London, and colleagues examined the role of variation in cardiomyopathy- ...
... sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. In: ... sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ... sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy, ... sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. ...
Affected by alcoholic cardio myopathy, mild diabetic, stopped alcohol. How long can i live?. Ask a Doctor about uses, dosages ... I am 59 years old and affected by alcoholic cardio myopathy . My EF is 40% . I have completely stopped alcohol. I want to know ... Affected by alcoholic cardio myopathy, mild diabetic, stopped alcohol. How long can i live?. ... There are very good drugs to control Cardiomyopathy like ACE inhibitor,Beta blocker as tolerated and Levocarnitine,and cardiac ...
Alcoholic Cardiomyopathy Introduction. Alcoholic cardiomyopathy is prevalent in men between 35 and 55 years of age, but it may ... life expectancy for dilated cardiomyopathy postpartum cardiomyopathy dialated cardiomyopathy How is hypertrophic cardiomyopathy ... Symptoms of Alcoholic Cardiomyopathy. In early stages alcoholic cardiomyopathy is usually asymptomatic. However, as the disease ... Treatment for Alcoholic Cardiomyopathy. Diagnosis of alcoholic cardiomyopathy is based on physical examination, medical history ...
What is alcoholic cardiomyopathy? Meaning of alcoholic cardiomyopathy medical term. What does alcoholic cardiomyopathy mean? ... Looking for online definition of alcoholic cardiomyopathy in the Medical Dictionary? alcoholic cardiomyopathy explanation free ... Synonym(s): alcoholic myocardiopathy, beer heart. alcoholic cardiomyopathy. Etymology: Ar, alkohl, essence; Gk, kardia, heart, ... "Animal Models of Alcoholic Cardiomyopathy," pp.. 1994), (For information on a chicken model of alcoholic cardiomyopathy, see ...
Alcohol use can lead to alcoholic cardiomyopathy, which has the potential to progress and lead to congestive heart failure if ... How is alcoholic cardiomyopathy diagnosed?. If you suspect you may have alcoholic cardiomyopathy, make an appointment with a ... Can alcoholic cardiomyopathy be treated?. While there is no foolproof treatment for alcoholic cardiomyopathy, certain steps can ... What are the symptoms of alcoholic cardiomyopathy?. Alcoholic cardiomyopathy can be dangerous because it may be asymptomatic ...
Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; ... or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and ...
American Roentgen Ray Society Images of Alcoholic cardiomyopathy physical examination All Images. X-rays. Echo & Ultrasound. CT ... Patients with alcoholic cardiomyopathy present with signs similar to that of heart failure. Most common findings include pedal ... Retrieved from "https://www.wikidoc.org/index.php?title=Alcoholic_cardiomyopathy_physical_examination&oldid=1225161" ... Other sequelae of alcoholic liver disease may also be noted on physical examination. ...
American Roentgen Ray Society Images of Alcoholic cardiomyopathy primary prevention All Images. X-rays. Echo & Ultrasound. CT ... Retrieved from "https://www.wikidoc.org/index.php?title=Alcoholic_cardiomyopathy_primary_prevention&oldid=1225162" ...
Common symptoms caused by alcoholic cardiomyopathy are: a decreased urine output, swollen ankles, legs and feet, loss of ... How is alcoholic cardiomyopathy treated?. The first thing to do to treat alcoholic cardiomyopathy is for you to put a complete ... What is alcoholic cardiomyopathy?. Alcoholic cardiomyopathy is one of the consequences of prolonged use of alcohol. ... How is alcoholic cardiomyopathy diagnosed?. To diagnose you of alcoholic cardiomyopathy, your doctor will have to examine you ...
... alcoholic cardiomyopathy, and muscle damage. Further, we have reviewed the role of altered microRNAs in the circulation, ... In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal ... Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ... females are more susceptible to alcoholic myopathy and cardiomyopathy than male counterparts [172,173]. Alcoholic myopathy was ...
  • Alcoholic polyneuropathy or bilateral common peroneal nerve palsy was suspected as the preliminary diagnosis and electroneuromyography (ENMG) was performed which revealed normal conduction velocities of the bilateral sural, median, and ulnar nerves. (thefreedictionary.com)
  • A review of the human literature implicates nutritional deficiencies, most often thiamine deficiency, that are common in alcoholic patients, as commonly accompanying complicating factors in the development of this neuropathy. (medscape.com)
  • Thiamine deficiency is commonly found in alcoholic patients, due to decreased absorption and hepatic depletion. (medscape.com)
  • Severe cases of alcoholic neuropathy can lead to the development of symptoms in the proximal lower extremities and distal upper extremities. (medscape.com)
  • Another study demonstrated that in a rat model, tocotrienol, an isoform of vitamin E, given after the development of alcoholic neuropathy may be neuroprotective via its antioxidant properties. (medscape.com)
  • In most cases of alcoholic neuropathy, the onset of the polyneuropathy is insidious and prolonged, but some cases have been associated with acute, rapidly progressive onset. (medscape.com)
  • These might include: Shortness of breath Syncope (fainting) Angina, but only in the presence of ischemic heart disease A person suffering from dilated cardiomyopathy may have an enlarged heart, with pulmonary edema and an elevated jugular venous pressure and a low pulse pressure. (wikipedia.org)
  • Most guidelines on alcohol consumption recommend that men should regularly consume no more than two alcoholic drinks per day and that women should regularly consume no more than one drink per day (a "drink" is, roughly speaking, a can of beer or a small glass of wine). (plos.org)