Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
An island in the Greater Antilles in the West Indies. Its capital is Kingston. It was discovered in 1494 by Columbus and was a Spanish colony 1509-1655 until captured by the English. Its flourishing slave trade was abolished in the 19th century. It was a British colony 1655-1958 and a territory of the West Indies Federation 1958-62. It achieved full independence in 1962. The name is from the Arawak Xaymaca, rich in springs or land of springs. (From Webster's New Geographical Dictionary, 1988, p564 & Room, Brewer's Dictionary of Names, 1992, p267)
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Heart Defects, Congenital
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A type of strength-building exercise program that requires the body muscle to exert a force against some form of resistance, such as weight, stretch bands, water, or immovable objects. Resistance exercise is a combination of static and dynamic contractions involving shortening and lengthening of skeletal muscles.
The oxygen consumption level above which aerobic energy production is supplemented by anaerobic mechanisms during exercise, resulting in a sustained increase in lactate concentration and metabolic acidosis. The anaerobic threshold is affected by factors that modify oxygen delivery to the tissues; it is low in patients with heart disease. Methods of measurement include direct measure of lactate concentration, direct measurement of bicarbonate concentration, and gas exchange measurements.
Muscle Stretching Exercises
Exercises that stretch the muscle fibers with the aim to increase muscle-tendon FLEXIBILITY, improve RANGE OF MOTION or musculoskeletal function, and prevent injuries. There are various types of stretching techniques including active, passive (relaxed), static, dynamic (gentle), ballistic (forced), isometric, and others.
Pulmonary Gas Exchange
Physical Education and Training
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Exercise Movement Techniques
A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Cardiovascular Physiological Phenomena
Analysis of Variance
Respiratory Function Tests
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Quality of Life
Fatty Acids, Nonesterified
Physical Therapy Modalities
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Body Temperature Regulation
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Pulmonary Disease, Chronic Obstructive
Recovery of Function
Ventricular Function, Left
Blood Flow Velocity
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
The incognita of the known: the athlete's heart syndrome. (1/17)(+info)
The prevalence, distribution, and clinical outcomes of electrocardiographic repolarization patterns in male athletes of African/Afro-Caribbean origin. (2/17)(+info)
Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants. (3/17)(+info)
Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. (4/17)(+info)
Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise. (5/17)(+info)
Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. (6/17)(+info)
The endurance athletes heart: acute stress and chronic adaptation. (7/17)(+info)
Atrial fibrillation and atrial flutter in athletes. (8/17)(+info)
Do big athletes have big hearts? Impact of extreme anthropometry upon cardiac hypertrophy in professional male athletes<...
TY - JOUR. T1 - Do big athletes have big hearts? Impact of extreme anthropometry upon cardiac hypertrophy in professional male athletes. AU - Riding, Nathan R.. AU - Salah, Othman. AU - Sharma, Sanjay. AU - Carré, François. AU - OHanlon, Rory. AU - George, Keith P.. AU - Hamilton, Bruce. AU - Chalabi, Hakim. AU - Whyte, Gregory P.. AU - Wilson, Mathew G.. PY - 2012/11. Y1 - 2012/11. N2 - Aim Differentiating physiological cardiac hypertrophy from pathology is challenging when the athlete presents with extreme anthropometry. While upper normal limits exist for maximal left ventricular (LV) wall thickness (14 mm) and LV internal diameter in diastole (LVIDd, 65 mm), it is unknown if these limits are applicable to athletes with a body surface area (BSA) ,2.3 m 2. Purpose To investigate cardiac structure in professional male athletes with a BSA,2.3 m 2, and to assess the validity of established upper normal limits for physiological cardiac hypertrophy. Methods 836 asymptomatic athletes without a ...
miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury
Limited microRNAs (miRNAs, miRs) have been reported to be necessary for exercise-induced cardiac growth and essential for protection against pathological cardiac remodeling. Here we determined members of the miR-17-92 cluster and their passenger miRNAs expressions in two distinct murine exercise models and found that miR-17-3p was increased in both. miR-17-3p ... read more promoted cardiomyocyte hypertrophy, proliferation, and survival. TIMP-3 was identified as a direct target gene of miR-17-3p whereas PTEN was indirectly inhibited by miR-17-3p. Inhibition of miR-17-3p in vivo attenuated exercise-induced cardiac growth including cardiomyocyte hypertrophy and expression of markers of myocyte proliferation. Importantly, mice injected with miR-17-3p agomir were protected from adverse remodeling after cardiac ischemia/reperfusion injury. Collectively, these data suggest that miR-17-3p contributes to exercise-induced cardiac growth and protects against adverse ventricular remodeling. miR-17-3p may ...
Buy 2Pcs Womens Anklet Chains Flower Heart Pattern Chic Body Chains Accessory & Body Chains - at Jolly Chic
2Pcs Womens Anklet Chains Flower Heart Pattern Chic Body Chains Accessory Item Id : #A2W990AW1WF , Style : Casual, Sexy, Vintage, Sweet, OL, Punk, Top Fashion, Celebrity, Pastoral, Ethnic , Decoration : Beading, Flowers , Pattern : Geometric, Floral
Cardiovascular reactivity patterns and pathways to hypertension: A multivariate cluster analysis - Department of Paediatrics
© 2016 Macmillan Publishers Limited, part of Springer Nature. Substantial evidence links exaggerated mental stress induced blood pressure reactivity to future hypertension, but the results for heart rate reactivity are less clear. For this reason multivariate cluster analysis was carried out to examine the relationship between heart rate and blood pressure reactivity patterns and hypertension in a large prospective cohort (age range 55-60 years). Four clusters emerged with statistically different systolic and diastolic blood pressure and heart rate reactivity patterns. Cluster 1 was characterised by a relatively exaggerated blood pressure and heart rate response while the blood pressure and heart rate responses of cluster 2 were relatively modest and in line with the sample mean. Cluster 3 was characterised by blunted cardiovascular stress reactivity across all variables and cluster 4, by an exaggerated blood pressure response and modest heart rate response. Membership to cluster 4 conferred an
Exercise-induced cardiac growth factors govern c-kitpos | Open-i
Exercise-induced cardiac growth factors govern c-kitpos endogenous cardiac stem-progenitor cell growth and differentiation in vitro. (A-F) Histogram plots and
Exercise Intolerance in Renal Failure - Full Text View - ClinicalTrials.gov
Patients with chronic kidney disease have profound exercise intolerance which contributes to an increased risk of cardiovascular disease. The investigators have found that chronic kidney disease patients have an exaggerated increase in blood pressure during certain forms of exercise that could certainly contribute to exercise dysfunction as well as cardiovascular risk. The investigators will test the mechanisms underlying this exaggerated blood pressure response, as well as the potential benefits of short-term tetrahydrobiopterin (BH4) with folic acid on both exercise dysfunction and cardiovascular risk factors in chronic kidney disease. The investigators will test whether short-term treatment with tetrahydrobiopterin (BH4), a cofactor for nitric oxide, together with folic acid improves inflammation, vascular health, and adrenaline levels, both at rest and during exercise in chronic kidney disease ...
Sleep disordered breathing tied to lower exercise capacity
(HealthDay)-Sleep-disordered breathing (SDB) severity is associated with lower functional aerobic capacity (FAC) and increased blood pressure, according to a study published in the June 1 issue of The American Journal of ...
3D Abstract Heart Pattern Silicon AirPod Case | Kalakaar Indiaa
UNLIKE OTHER GENERIC CASES THAT are mass produced, all of our cases are designed IN HOUSE FROM SCRATCH. From a concept, all the way to a finished product, every aspect of creating a product is done in-house to ensure that you get a case that WILL FIT PERFECTLY, HELP PROTECT FROM DROPS, AND LOOKS GREAT - SAVING YOU TIME
Heart Pattern Color Block Soft Long Sweatshirt (BLACK,M) in Sweatshirts & Hoodies | DressLily.com
Youve used up all your tries today. You can only share up to 10 items per day. Please come back tomorrow to share any other items youd like to get for free. ...
Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging - Inverted Asymmetrical hypertrophy of left...
This is a temporary file and hence do not link it from a website, instead link the URL of this page if you wish to link the PDF file ...
Gender specific regulation of physiological hypertrophy in mice in response to voluntary exercise - CLAHRC
Athletes Heart - Cardiovascular Disorders - Merck Manuals Professional Edition
Athletes Heart - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.
Archives of Cardiovascular Diseases Supplements
The objective of this work is to study in cardiac MRI the difference between the physiological hypertrophy of the myocardium of the athletes heart and the hypertrophy of the pathological myocardium by comparing athletes (athlete group) to a group of subjects. non-athlete followed for HCM (HCM group).Material and methodsWe conducted a prospective comparative study including 61 subjects. The group of athletes comprised 31 subjects. TheHCM group consisted of 30 subjects. All subjects were paired to age and body surface and had cardiac MRI with the late enhancement study.ResultsThe thickness of the LV wall (mea ...
Athletes Heart - Cardiovascular Disorders - Merck Manuals Professional Edition
Learn about the causes, symptoms, diagnosis & treatment of Sports and the Heart from the Professional Version of the Merck Manuals.
MARNI MARKET N S Shopping Bag In Polypropylene With Heart Pattern | Marni
MARNI MARKET N S Shopping Bag In Polypropylene With Heart Pattern from the Marni Fall/Winter 2020 collection. Shop online on the official store and discover the full catalogue.
Reduced ischemia and reperfusion injury following exercise training<...
TY - JOUR. T1 - Reduced ischemia and reperfusion injury following exercise training. AU - Libonati, Joseph R.. AU - Gaughan, John P.. AU - Hefner, Colleen A.. AU - Gow, Andrew. AU - Paolone, Albert M.. AU - Houser, Steven R.. PY - 1997. Y1 - 1997. N2 - We examined the effects of two exercise training modalities, i.e., low intensity endurance and sprint running, on in vitro, isovolumic myocardial performance following ischemia and reperfusion. Rats ran on a treadmill 5 d · wk-1 for 6 wk at the following levels: endurance; 20 m · min-1, 0% grade, 60 min · d-1 and sprint; five 1-min runs at 75 m · min-1, 15% grade interspersed with 1-min active recovery runs at 20 m · min-1, 15% grade. Both endurance and sprint training significantly improved exercise tolerance relative to control (P ,0.05) on two graded exercise tests. Buffer perfused hearts of control (N = 18), endurance (N = 20), and sprint (N = 13) trained animals underwent no-flow ischemia (20 min) and reperfusion (30 min) in a ...
Treadmill BP in Simulated Peripheral Artery Disease
What is driving the exaggerated blood pressure response to exercise in patients with peripheral arterial disease (PAD)? In this podcast, Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews senior author Gail Thomas (Penn State College of Medicine) and content expert Hanjun Wang (University of Nebraska Medical Center) about the unique study by Kuczmarski et al. Thomas and co-authors used telemetry to record blood pressure during exercise in conscious animals, both before and after bi-lateral femoral artery ligation. The studied was conducted over a period of two months, a technical success given that the authors used chronically-instrumented conscious animals. Thomas and collaborators found that the blood pressure response was exaggerated as early as 3 days after femoral artery ligation and lasted for the duration of the experiment in both female and male mice. Are the mechanisms that play a role in blood pressure response to short-term ligation, such as cytokines ...
Audio professional male voice needed short recordings Jobs, Ansættelse | Freelancer
Søg efter jobs der relaterer sig til Audio professional male voice needed short recordings, eller ansæt på verdens største freelance-markedsplads med 16m+ jobs. Det er gratis at tilmelde sig og byde på jobs.
Picture of the Day: Worlds Oldest Marathon Runner, 100 year-old Fauja Singh » TwistedSifter
WORLDS OLDEST MARATHON RUNNER, 100 YEAR-OLD FAUJA SINGH Photograph via Reddit Fauja Singh (born April 1, 1911) is a centenarian Sikh. He is a marathon runner of Indian descent who is a world record holder in his age bracket.
Pertussis in Soldiers, Israel - Volume 11, Number 3-March 2005 - Emerging Infectious Disease journal - CDC
To the Editor: The role of adults as reservoirs of pertussis was previously well established (1-7). Young army recruits undergoing basic training in the Israeli Defense Force constitute a unique adult population because of their special living and service conditions. This and the fact that they are not vaccinated with the diphtheria, tetanus, and pertussis (DTP) vaccine after the age of 1 year (unlike children in most of the Western countries) led us to hypothesize that this semiclosed population may have an exceptionally high risk for pertussis. These young soldiers are on leave on weekends, during which time they come in close contact with susceptible family members, including young infants, and may thus facilitate the import and export of pertussis between the military setting and the general population. An outbreak of pertussis that recently occurred among infantry soldiers (8) indicated the need to conduct the present study, in which we sought to evaluate the prevalence and incidence of ...
marathon runner height
writes: Who knows for sure - it seems most elite marathon runners tend to be on the short side. Luke Puskedra is the newest member of a select group. However, this is inevitable since it appears the suggested values were based on real-life heights and weights of professional runners. After delivering PPE at the height of the pandemic, the pre-med student is running the virtual New York City Marathon to raise funds for health care workers in need. The theory is that, because foot size doesnt necessarily increase in proportion to height, taller runners are subject to greater biomechanical forces, and could have an increased susceptibility to injury. We may earn commission if you buy from a link. This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. Related, the similarly built shorter runner has a relatively greater surface area, which, everything else being equal, allows for better heat dissipation. Thereafter, he is ...
World s Oldest Marathon Runner to Retire Aged 101
The world s oldest marathon runner has revealed that he will be retiring at the age of 101 years after one final run in Hong Kong next month.
Marathon Runner Reunited With Stray Dog Who Followed Him & Now Theyre Both Heading Home
Like all good stories the story of Dion Leonard, a marathon runner from Scotland, and a stray dog now named Gobi has many twists and turns along the way.
The Average Athletes Heart Rate During a Marathon | Chron.com
The average athletes heart rate during a marathon is 160 beats per minute. Thats based on a person in his or her 20s who has a resting heart rate of 55 bpm and a maximum heart rate of 200 bpm. A ...
Heart Rhythm Stabilization | Heart & Vascular | Lexington Medical Center
Our Heart & Vascular Center offers dedicated heart rhythm suites and the most advanced technology to detect and treat irregular heart patterns.
Background Blocks Scattered Hearts Clear Stamp - Uniko
Another addition to the clear stamp series called Background Blocks. They are what they say, simply a block of yummy pattern!. Background Blocks Scattered Hearts. This is a lovely scattered outline heart design, which can be stamped once to create a backdrop for a focal point. It has also been designed to be able to stamp to fill a large area to create a random scattered heart pattern.. This stamp measures approximately 6.5 x 9 cm.. PLEASE NOTE:- To protect my designs and discourage the blatant theft of them, there is a watermark over the top of the product image. This makes the image appear that the lines are not solid. I apologise for the inconvenience and ensure you that this is not part of the design or physical stamps you will receive. To see what the stamp/s look like when stamped, please have a look at the samples in the product gallery. Thank you for your understanding. ...
From Diet To Drinking: A Week In the Life Of An Elite Rugby Union Star
From diet to weekly exercise regimes and everything in between, Harlequins coach Adam Bishop gives loaded the lowdown on what is expected at the elite level
Is It Safe For My Teenager To Run Marathons? | Runners World
I have been running for years and started running marathons in the past 3 years. My 16-year-old son finished the Napa Valley Marathon with me. He started running 8 months ago as a way to lose weight. I have consistently asked him if he wanted to go running, but he was never interested before. My wife and I thought the marathon training was a one off; hed do it and thatd it. He finished in 3:15 and now he wants to runs 2-4 marathons a year. Hes running track in high school for the first time right now (1600 and 3200 meters).
And a (Ultra)Marathon Runner was Born: But I want to now!
Im not sure yet. I will be running a marathon the weekend before, so it depends on how my legs feel. I intend to run full out at this marathon. I have a few friends that will be running the SFM so Im thinking of doing the second half (because the first half is just TOO EARLY!) as a fun run and enjoying yet another race experience. Plus it was my very first 1/2 marathon I did...would be nice to start a tradition!. ...
Veggie Runners Baby - Pregnant Marathon Runner Alert! - Veggie Runners
Bibi is having a baby! Two days after running the London Marathon, she discovered she was pregnant. This post shares some thoughts and research on running while trying to conceive, running during pregnancy and marathon training with a baby on board.
The Trials and Tribulations of a Novice Marathon Runner - Hope Fitness
In 2007 I ran the marathon to celebrate my 30th birthday and raise money for St. Elizabeths Hospice, Ipswich, who cared for my Dad in his last few days. Needless to say I am not a natural runner and the experience is one I will never forget.. Prepare yourself for blood, sweat and tears... Wednesday 27th December 2006 20 Minutes approx. 3.21km (On Treadmill). First day of training today. This time yesterday I was eating my second Christmas dinner! Anyway, was able to complete 20 minutes on the treadmill at 10km/hr comfortably so a good start. However, it will be much harder out on the roads so I can look forward to that!. Thursday 28th December 2006 30 Minutes approx. 2.3km. First run outside and started off quite well although I think I started off too fast. Wanted to die after the first very slight hill! I ran round the Orwell Country Park, which was a bit too muddy and slippery. I couldnt complete the 30 minutes; I had to walk one bit of my route (which was uphill and muddy) but then ...
What Makes Kenyas Marathon Runners The Worlds Best? : Goats and Soda : NPR
Kenyan distance runners won both the mens and womens divisions of Sundays New York City Marathon. A Harvard evolutionary biologist suggests some possible reasons why.
And a (Ultra)Marathon Runner was Born: When did running 6 miles get hard??
Now I find myself slowing down, but going much longer distances. I guess Im really becoming an ultramarathoner. Its funny how after two marathons, I still didnt see myself as a marathoner or even a real runner. Since then, I have run about 7 ultras and now across the state of Iowa and Im now thinking I might be an ultramarathoner. Its funny how my past can play such a big part of my view of my world and my future ...
Is Tony The Fridge the worlds most extreme marathon runner? - Telegraph
As Mo Farahs collapse at the New York half marathon shows how tough long distance running can be, meet Tony The Fridge Morrison, who runs with a 42kg refrigerator strapped to his back
Masterminding the Marathon | Runners World
A month after giving birth to our first child, my wife, Macy, had a crazy idea. She wanted to set a personal best in the marathon. And she wanted to do it soon.
Sharon is a mom, a marathon runner, and a licensed therapist. Using Jeff Galloways Run-Walk-Run method, she went from being a non-runner to a marathon runner in one year. She is a passionate advocate of the Galloway training method and knows firsthand that everyday moms can run marathons.
Marathon Runners Face Low Risk Of Cardiac Arrest | WKAR
Running long-distance races isn't going to hurt your heart any more than other vigorous sports, researchers say. Just make sure you're fit enough
NC mom, former marathon runner thriving after losing 3 limbs to flu | myfox8.com
MATTHEWS, N.C. -- A North Carolina mom is thriving once again after losing three limbs to the flu just two years ago. In 2013, Kristan Seaford caught a bad case of the flu that turned into sepsis and nearly killed her, according to WCNC.
Point of Care Testing Aids Collapsed Marathon Runners
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Point of Care Testing Aids Collapsed Marathon Runners
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
Soldiers, snakes and marathon runners in hidden world of fungi | Mirage News
Researchers at Lund University in Sweden have discovered the individual traits of fungi, and how their hyphae - that is, the fungal threads that grow in...
Counterpoint: lack of evidence for echocardiography screening in athletes | Heart
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Army takes a steady, cautious approach to women in infantry - News - Ashland Times-Gazette - Ashland, OH
FORT BENNING, Ga. (AP) - The young Army infantry recruits lined up in full combat gear, guns at the ready. At the signal, a soldier in front kicked in the door and they burst into the room, swiveling to check around the walls for threats. Youre dead! one would-be enemy yelled out from a dark corner, the voice slightly higher than the others echoing through the building. It was 18-year-old Kirsten, training to become one of the Armys first women serving as infantry soldiers.
Army takes a steady, cautious approach to women in infantry
FORT BENNING, Ga. (AP) - The young Army infantry recruits lined up in full combat gear, guns at the ready. At the signal, a soldier in front kicked in the door and they burst into
Fatal fall of Wright airship - Wikisource, the free online library
WASHINGTON, Sept. 17.―Falling from a height of 75 feet, Orville Wright and Lieut. Thomas E. Selfridge of the Signal Corps were buried in the wreckage of Wrights aeroplane shortly after 5 oclock this afternoon. The young army officer died at 8:10 oclock to-night. Wright is badly hurt, although he probably will recover. The flying machine is a mass of tangled wires, torn and twisted planes, and tattered canvas. The accident was due to the breaking of one of the blades of the propeller on the left side.. Although there had been but a handful of people at the aeronautical testing grounds at Fort Myer during the last few days, fully 2,000 had gathered by 4:30 this afternoon. The aeroplane was still in its shed, but Mr. Wright arrived a few minutes later and ordered it taken to the northern end of the field, to be placed on the starting track in readiness for a flight.. Selfridge In First.. Everybody was ordered back from the machine, and Mr. Wright turned to Lieut. Selfridge and said: You might ...
What is Oxycodones nickname? | Socratic
See this site. Do not be tempted. It used to be called hillbilly heroin, before it became the drug of choice for older professional males.
A Marathon Mentality for Ministry | The Christward Collective
I was always better at sprinting than running long distance--back in the days when I actually ran...in high shcool. My wife, by way of contrast, was and is a marathon runner. One of the things that Ive noticed as I have watched her run over the years is that she knows how to pace herself.
IF Bekele were to race Farah next year, what strategy could he use?
Another way to estimate is to look at the typical slowdown from 10K pace to marathon pace, which for world-class marathon runners is usually around 24 seconds per mile (6 seconds per 400m) to 28 seconds per mile (7 seconds per 400m). Bekele just ran a marathon at just under 70.0 seconds per 400m, which would work out to a 10K between 26:15 (63 sec pace) and 26:40 (64 sec pace)â€¦.while Mo Farah has a 10K PR of 26:46 ...
Compression Arm Sleeves / Pair | McDavidUSA
The best compression arm sleeves to promote blood flow and circulation for running, crossfit training, ultra runners, marathon runners, and triathletes. Also great for obstacle race running and trail running.
Collective Diary 1-2 years | Cancer and Careers
Type and Description of Treatments: I recieved 6 rounds of CHOP+E chemotherapy from June 2016 to December 2016. At the end of Januar... How do you feel today? Same as everyday. Very difficult to get going after waking up in the morning. It always feels like it takes until 5 in the afternoon before I feel fully awake. I try to exercise but the toll the stem cell transplant and other treatments have taken on me is profound. I used to be a marathon runner but the effort of running even 1 mile... Continue Reading ...
The Beautiful Life Of The Girl Next Door
So why do I feel the need to write this all out? Because it drives me mad that people, who have no idea what its like to have cancer, feel like they can call people, who are fighting for their lives, liars because we dont look sick enough. Why do I have to look sick for you to believe me? First, what does sick look like? And why is it that me looking sick would make you feel more comfortable? Does it make you uncomfortable because if a normal looking girl can get cancer, that means that you could too? You could. Anyone can get cancer. It does not care how old, young, strong, healthy, you are. You could be a vegan marathon runner and somehow still end up with cancer. Anyone could have or get cancer ...
National Running Day Tips | Glamour
Just in case your feet were feeling the need to get moving (maybe this 91-year-old marathon runner was some inspiration?), today just happens to be National...
How Jogging Can Add Years to Your Life | Washingtonian (DC)
For those who trot along the track as speed demons whiz by, rejoice! You dont have to be a sprinter or marathon runner to add years to your life--jogging at a slow or average pace for a couple hours...
... induced by exercise could be suggestive of cardiomyopathy, ischemia or channelopathies. The most important initial ... Evidence of cardiomegaly and peripheral edema may indicate heart failure and ischemia or a valvular abnormality. Blood tests, ... Supraventricular tachycardias can also be induced at the termination of exercise when the withdrawal of catecholamines is ... Vagus nerve induced palpitation is felt as a thud, a hollow fluttery sensation, or a skipped beat, depending on at what point ...
It is not uncommon to undergo cardiopulmonary exercise testing (CPET), which measures the heart's response to exercise, to ... it is believed that the eccentric hypertrophy is induced by volume-overload and that the concentric hypertrophy is induced by ... Athletic heart syndrome Cardiac fibrosis Cardiology Cardiomegaly Cardiovascular disease Right ventricular hypertrophy ECG See ... It is a response to 'volume-overload', either as a result of increased blood return to the heart during exercise, or a response ...
A patient with a frame shift mutation of c.227delC displayed symptoms of neutropenia, cardiomegaly, and other common symptoms ... Based on studies of cervical cancer progression, it is believed that TAZ may induce cancer by inhibiting apoptosis and ... November 2011). "Impaired cardiac reserve and severely diminished skeletal muscle O₂ utilization mediate exercise intolerance ... Another c.C153G mutation resulted in severe metabolic acidosis, cardiomegaly, and other major symptoms of Barth syndrome. There ...
Tentative evidence suggests that home-based exercise programs may be more efficient at improving exercise adherence. While a ... Cardiovascular late side-effects have been termed radiation-induced heart disease (RIHD) and radiation-induced vascular disease ... Inflammatory cardiomegaly Myocarditis - inflammation of the myocardium, the muscular part of the heart, caused most often by ... Insufficient physical activity (defined as less than 5 x 30 minutes of moderate activity per week, or less than 3 x 20 minutes ...
Incidents at Six Flags parks
The boy was put into a medically induced coma and taken to a hospital; there, he underwent head surgery, in which a portion of ... On January 5, 1996, two trainers were injured by cougars during an exercise session. One trainer was in the cougar enclosure to ... the coroner's report later stated that she died due to cardiomegaly, and had been seeing a cardiologist for treatment. On ...
People with Lyme arthritis should limit their level of physical activity to avoid damaging affected joints, and in case of ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... In 10-15% of people, Lyme causes myocardial complications such as cardiomegaly, left ventricular dysfunction, or congestive ... Schneider BS, Schriefer ME, Dietrich G, Dolan MC, Morshed MG, Zeidner NS (October 2008). "Borrelia bissettii isolates induce ...
Heart failure with preserved ejection fraction
... manifestations of HFpEF are similar to those observed in HFrEF and include shortness of breath including exercise induced ... and is associated with improved aerobic exercise capacity. The benefit patients seem to derive from exercise does not seem ... The former is the result of stress, such as exercise, while the latter is the result of reduced coronary flow. ... This is undertaken because perturbations in diastole are exaggerated during the increased demands of exercise. Exercise ...
Shortness of breath, chest pain, decreased ability to exercise, irregular heartbeat. ... decreased ability to exercise, and an irregular heartbeat. The duration of problems can vary from hours to months. ... A period of no exercise is typically recommended during recovery. Corticosteroids or intravenous immunoglobulin (IVIG) ...
Long-term endurance exercise that far exceeds the recommended amount of exercise (e.g., long-distance cycling or marathon ... Finally, nicotine induces the formation of patterns of collagen type III in the atrium and has profibrotic effects. All this ... Exercise stress testing. Some individuals with atrial fibrillation do well with normal activity but develop shortness of ... Regular aerobic exercise improves atrial fibrillation symptoms and AF-related quality of life. The effect of high-intensity ...
This is the basis for the so-called fight-or-flight response, but such stimulation can also be induced by stimulants such as ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ... such as with exercise) or abnormal (such as with electrical problems within the heart). ...
Coronary artery disease
Medications and exercise are roughly equally effective. High levels of physical activity reduce the risk of coronary artery ... Chronic high-grade narrowing of the coronary arteries can induce transient ischemia which leads to the induction of a ... Exercise; aerobic exercise, like walking, jogging, or swimming, can reduce the risk of mortality from coronary artery disease.[ ... Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Major Recommendations ...
AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in...
The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury by ... Nandrolone impaired the exercise-induced cardioprotection, but this effect was prevented by losartan (AT1-R antagonist) and ... AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in ... Conclusion: The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury ...
A case of cough and breathlessness | Thorax
By contrast, the exercise induced dyspnoea and orthopnoea progressed to the point where his capacity to perform activities of ... GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. Spirometry was normal (forced expiratory volume in ... His chest X-ray now showed cardiomegaly, blunted costophrenic angles and bilateral lower zone infiltrates. A further ... peripheral oedema and a reduction in exercise tolerance to approximately 10 m walking. Upper gastrointestinal endoscopy was ...
PPT - Atrial FIbrillation PowerPoint Presentation, free download - ID:2355873
AF-Additional Testing • May be indicated in some circumstances • Stress testing • If AF is exercise induced • To assess rate ... AF-Initial Workup • Chest X-ray • Cardiomegaly • Pulmonary disease • Blood work • Thyroid functions • BMP • Hepatic profile • ... AF-Goals of Therapy • Rate control • Most important initial strategy • Prevention of CHF (tachycardia induced cardiomyopathy ...
Fire Fighter Fatality Investigation Report F2004-30 | NIOSH | CDC
Use of Exercise Stress Tests (EST) to Screen for CAD. To reduce the risk of heart attacks and sudden cardiac arrest among FFs, ... Cardiomegaly (an enlarged heart) weighing 560 grams (normal is less than 400 grams)1 ... but his untimely death is much more likely due to an MI-induced heart arrhythmia. ... Consider conducting exercise stress tests for male FFs above the age of 45 years with two or more risk factors for CAD. ...
Fire Fighter Fatality Investigation Report F2012-11 | NIOSH | CDC
5) Exercise-induced ischemia or ventricular arrhythmias observed by radionuclide stress test during an evaluation reaching at ... Cardiomegaly (enlarged heart; heart weighed 660 grams [g]; predicted normal weight is 463 g [ranges between 351 g and 611 g as ... Health and Wellness Programs. The FD does not have a wellness/fitness program, and no exercise equipment is available in the ... 4) Maximal exercise tolerance of , 42 milliliters of oxygen per minute per kilogram or , 12 metabolic equivalents (METs) ...
ALCAPA Presents in an Adult with Exercise Intolerance but Preserved Cardiac Function
Here we report a case of a 20-year-old woman with a history of exercise intolerance since childhood that was misinterpreted as ... with chronic dyspnea on exertion and exercise intolerance that was attributed to and treated as presumed exercise-induced ... Chest X-ray showed no cardiomegaly (Supplemental Figure 2). Serial cardiac enzymes were negative. In the light of cardiac ... as exercise-induced asthma. The key for an early diagnosis before the occurrence of permanent cardiac damage is a careful ...
... decreased exercise capacity and shortness of breath during exercise ■ ECG: low voltage of QRS complexes and P and T waves ■ CXR ... Clinical Manifestations of Hypothyroidism -- Cardiovascular System ■ Myxedema induces coronary artery disease ?? ■ CAD more ... cardiomegaly interstitial edema, myofibrillary swelling, LV dilatation, pericardial effusion * 11. ... and decreased exercise capacity impaired respiratory function + cardiovascular disease ■ Hypoventilation (shallow and slow ...
Hemodynamic collapse induced by general anesthesia in a patient with an unruptured thoracic aortic aneurysm: a case report |...
However, his exercise tolerance was well. Any dyspnea on effort had not seen during out-patient clinic (NYHA I). Ventilation/ ... A chest radiograph revealed marked cardiomegaly and mediastinum expansion without a difference of increased radiolucency ... Hemodynamic collapse induced by general anesthesia in a patient with an unruptured thoracic aortic aneurysm: a case report. ... Two cases of TAA-induced severe hypoxia with compression of the left main bronchus and right pulmonary artery have been ...
Canadian Cyclist annie-ewart-a-career-cut-short
Ethnic and Gender Specific Differences Among Athletes Participating in ECG Screening - American College of Cardiology
Cardiomegaly, Exercise-Induced, Cardiomyopathies, Coronary Vessels, Death, Sudden, Cardiac, Echocardiography, ... Clinical Topics: Arrhythmias and Clinical EP, Heart Failure and Cardiomyopathies, Noninvasive Imaging, Sports and Exercise ... Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise ... Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes. ...
Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non...
Exercise capacity, lung congestion, maximal oxygen consumption, arterial oxygen saturation, and survivorship were all improved ... Results: At 100 days post-TAC, untreated KATP channel-deficient hearts developed cardiomegaly, regional and global left ... Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non- ... Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non- ...
WO2009071097A1 - Use of hypothermia inducing drugs - Google Patents
... thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. ... Cardiomegaly is a medical condition wherein the heart is enlarged. It can often be associated with other serious medical ... lack of exercise and increasing average lifespan. The main causes of death and disability among cardiovascular diseases are ... WO2009071097A1 - Use of hypothermia inducing drugs - Google Patents. Use of hypothermia inducing drugs Download PDF Info. ...
Sciblogs | Your Fitbit could warn you about heart disease
Also known as athletic bradycardia, or exercise-induced cardiomegaly, Athletes heart is generally considered benign, but may ... Activity data from wearables may help us identify individuals more likely to have this condition due to exercise, and are ... "An enlarged left ventricle could be caused by heart disease or harmless adaptation to sustained exercise, and these two ...
Sustained left ventricular diastolic dysfunction after exercise in patients with dilated cardiomyopathy | Heart
Moreover, the exercise induced diastolic dysfunction may persist despite cessation of exercise. Kono et al reported that the ... 1963) Value of prolonged bed rest in management of cardiomegaly. JAMA 183:81-87. ... 1993) Effect of heart failure on the mechanism of exercise-induced augmentation of mitral valve flow. Circ Res 72:795-806. ... Conclusions Exercise induced diastolic left ventricular dysfunction of the failing heart persists for 24 hours or more after ...
Blood pressure and left ventricular hypertrophy during american-style football participation<...
IMSEAR at SEARO: Search
1 Cardiomegaly, Exercise-Induced. *1 Congenital heart defects. *1 Congenital heart disease ... No Synergic Effect of Sildenafil Administration on Exercise Capacity Improvement in a Fontan Patient with Regular Exercise ... Kindergarten Children with Congenital Heart Disease Show Good Physical Activity but Reduced Motor Skills in Comparison with ...
IMSEAR at SEARO: Search
Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy<...
We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ...
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy<...
In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ...
Sudden cardiac death in athletes - PubMed
Search | Global Index Medicus
Exercise-Induced/genetics , Cardiomegaly/genetics , Exercise/physiology , MicroRNAs/physiology , Cardiomegaly, Exercise-Induced ... Animals , Male , Rats , Cardiomegaly, Exercise-Induced/drug effects , Cardiomegaly, Exercise-Induced/physiology , Heart/drug ... Humans , Atrial Fibrillation/etiology , Cardiomegaly, Exercise-Induced , Atrial Fibrillation/diagnosis , Cardiomegaly, Exercise ... There is no fibrosis and no cardiac dysfunction in eccentric or concentric hypertrophy induced by exercise training. Therefore ...
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide - SC 276 Summary Report |...
Cardiomegaly (Heart Hypertrophy) 10/15/1987 - "Lactate dehydrogenase activity increased significantly (P less than 0.01) in ... These data indicate that (1) beta-adrenergic blockade prevents training-induced cardiac hypertrophy; (2) beta-antagonists have ... myocardium may increase its ability to utilize lactate during exercise with training despite beta 1-blockade.". ...
PRIME PubMed | Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy
Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. Download Prime PubMed App to iPhone, iPad, or ... AndrogensAnimalsCardiomegalyFemaleGlucocorticoidsHeart VentriclesOrgan SizePhysical ExertionRatsRats, Inbred StrainsReceptors, ... Androgen cytosol binding in exercise-induced sparing of muscle atrophy.. *Glucocorticoid-induced cardiac hypertrophy: additive ... Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy.. Am J Physiol. 1984 Jun; 246(6 Pt 2):H761-7.AJ ...
CARDIOMEGALY, EXERCISE-INDUCED is also available. ... Cardiomegaly Entry term(s). Enlarged Heart Enlargement, Heart ... Cardiomegaly - Preferred Concept UI. M0009952. Scope note. Enlargement of the HEART, usually indicated by a cardiothoracic ... CI chemically induced. CL classification. CN congenital. CO complications. DG diagnostic imaging. DH diet therapy. DI diagnosis ... Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of ...
Search | Global Index Medicus
Animals , Male , Rats , Cardiomegaly, Exercise-Induced/drug effects , Cardiomegaly, Exercise-Induced/physiology , Heart/drug ... Objective: Assess hypertrophic response of the association of thyroid hormone and exercise in the rat heart. Methods: We used ... Conclusion: The association of thyroid hormone with high-intensity exercise produced cardiac hypertrophy, and generated a ... thyroid hormone and exercise (H + E); the group received daily hormone levothyroxine sodium by gavage at a dose of 20 μg ...
研究成果を検索 - 早稲田大学
Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac ... Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in ... Time dilation induced by object motion is based on spatiotopic but not retinotopic positions. Au, R. K. C., Ono, F. & Watanabe ... Time-dependent resonant UHF CI approach for the photo-induced dynamics of the multi-electron system confined in 2D QD. Okunishi ...
B. Merkely - Research Output - Hungarian Consortium
Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model. Oláh, A., ... Characterization of the dynamic changes in left ventricular morphology and function induced by exercise training and detraining ... Relationship between Cardiac Remodeling and Exercise Capacity in Elite Athletes: Incremental Value of Left Atrial Morphology ... sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular ...
Ventricular Function | Harvard Catalyst Profiles | Harvard Catalyst
Hemodynamics | Harvard Catalyst Profiles | Harvard Catalyst
Endothelin-1 - Endothelin 1 Summary Report | CureHunter
... in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. ". 02/ ... Cardiomegaly (Heart Hypertrophy) 04/01/1996 - "These data suggest that blocking the action of endothelin-1 with a receptor ... 06/01/2013 - "Based on these studies, drugs that increase NO bioavailability, attenuate endothelin-1 induced pulmonary ... 01/2010 - "The purpose of this study was to determine the role of endothelin 1 in mediating sFlt-1-induced hypertension in ...
HypertrophyDilated cardiomyopathyMild cardiomegalyMyocardialVascularTachycardiaHypertrophicAcuteToleranceIntoleranceMetabolismAthlete'sBradycardiaPhosphorylationMechanismsLungIschemiaHypoxiaReninAthletesDiastolicGlucocorticoidImpairsDysfunctionHypertensionArrhythmiasSyndromeHeart FailureBlockadeDyspnoeaMuscularTissueMyocardiumChronicLeftFindingsStressActivatesRenalPulmonary arteryMice
- Exercise studies were performed on females from six different genetic mouse models that have been shown to exhibit alterations in pathological cardiac adaptation and hypertrophy. (elsevier.com)
- Impact statement: This research is relevant as the hypertrophic signaling pathways tested here have only been characterized for their role in pathological hypertrophy, and not in the context of exercise or physiological hypertrophy. (elsevier.com)
- Given the potential overlap of insulin and IGF-1 signaling we sought to determine if both signaling pathways could contribute to exercise-induced cardiac hypertrophy following shorter-term exercise training. (elsevier.com)
- The extent of cardiac hypertrophy following exercise training in CIGFRKO and CIRKO mice was comparable to that in control mice. (elsevier.com)
- In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. (elsevier.com)
- Conclusion: The association of thyroid hormone with high-intensity exercise produced cardiac hypertrophy, and generated a standard hypertrophy not directly correlated to the degree of fibrosis. (bvsalud.org)
- Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. (bvsalud.org)
- Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. (bvsalud.org)
- This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway involved, also showing that the cardiac markers of pathological hypertrophy (atrial natriuretic factor, β-myosin heavy chain and α-skeletal actin) are not increased. (bvsalud.org)
- There is no fibrosis and no cardiac dysfunction in eccentric or concentric hypertrophy induced by exercise training. (bvsalud.org)
- Here, we show that the angiotensin II type 1 (AT1) receptor is locally activated in pathological and physiological cardiac hypertrophy, although with exercise training it can be stimulated independently of the involvement of angiotensin II. (bvsalud.org)
- These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy. (unboundmedicine.com)
- When stressors that encourage this concentric hypertrophy are reduced or eliminated (either surgically corrected in the case of cardiac defects, or hypertension is reduced from diet and exercise) it is possible for the heart to undergo 'reverse remodeling', returning to a somewhat more 'normal' state instead of progressing to a dilated, pathologic phenotype. (wikipedia.org)
- Swimming exercise, which is not accompanied by Gq activation, induced a normal cardiac response, while Rgs2 deletion in Galphaq-overexpressing hearts exacerbated hypertrophy and dilation. (tamu.edu)
- This resulted in extreme cardiomyocyte proliferation and hypertrophy - excessive growth of the individual cardiomyocytes - leading to a giant heart (cardiomegaly) that left little room for blood to enter. (labroots.com)
- We propose that growth-factor-induced skeletal-muscle hypertrophy and changes in myofibre phenotype are mediated by calcium mobilization and are critically regulated by the calcineurin/NF-ATc1 signalling pathway. (nih.gov)
- Various aetiologies, in reaction to this, may induce compensatory mechanisms consisting of excentric (dilatation) and concentric hypertrophy. (ox.ac.uk)
- Design and patients Transmitral flow velocity profiles and standard non-invasive haemodynamic indices were obtained serially over seven days after symptom limited bicycle exercise tests in 18 patients with dilated cardiomyopathy and eight normal subjects. (bmj.com)
- Results The intensity of exercise, as assessed by respiratory gas analysis, was lower in patients with dilated cardiomyopathy than in normal subjects. (bmj.com)
- In contrast, patients with dilated cardiomyopathy showed a sustained decrease in the peak early diastolic filling velocity and a sustained increase in the deceleration time of early filling for 24 hours or more after exercise. (bmj.com)
- Because other haemodynamic variables recovered within one hour after exercise even in patients with dilated cardiomyopathy, the postexercise changes in ventricular filling were not explained by changes in loading conditions. (bmj.com)
- The efficacy of exercise training on a daily basis in dilated cardiomyopathy requires further evaluation. (bmj.com)
- In this study, we investigated the recovery process of the exercise induced diastolic left ventricular dysfunction in patients with dilated cardiomyopathy, using reproducible Doppler echocardiographic techniques. (bmj.com)
- Myocardial tolerance to ischaemia/reperfusion (I/R) injury is improved by exercise training, but this cardioprotection is impaired by the chronic use of anabolic androgenic steroids (AAS). (nih.gov)
- 14 Because diastolic ventricular function is sensitive to transient myocardial metabolic insults, these findings suggest that exercise exerts a harmful metabolic effect on the failing myocardium through sympathetic stimulation. (bmj.com)
- If this is the case, the harmful metabolic effects may accumulate during exercise training or even during daily physical activities, promoting progression of myocardial failure. (bmj.com)
- and (3) while the training induction of myocardial hexokinase is inhibited by both beta 1- and beta 1 + beta 2-antagonists, myocardium may increase its ability to utilize lactate during exercise with training despite beta 1-blockade. (curehunter.com)
- Since mitochondria are responsible for the production of ATP, agents that interfere with the physiological myocardial mitochondrial function are expected to induce depletion of ATP pool. (southlaketimes.com)
- In these patients, bosentan was effective and was found to decrease vascular remodeling in induced pulmonary hypertension, improve myocardial function, and decrease ventricular remodeling. (vin.com)
- These oral medications have been shown to improve exercise intolerance, pulmonary arterial pressure, and even pulmonary vascular resistance in people. (vin.com)
- A, treatment is shorter act- ing exercise-induced and renin influ- ences vascular smooth muscle. (st-systemtronic.com)
- It is virtually totally excreted balance of vascular spasm of warfarin metabolism and cardiomegaly. (st-systemtronic.com)
- Trauma-associated dissections most frequently diagnosed viriga pills in a patient present with cardiomegaly, vascular congestion, or tenderness. (dvas.org)
- LV systolic, diastolic, and vascular function will be examined at rest and during graded supine exercise at fixed and varied preload to definitively characterize both baseline differences and discrepancies in cardiovascular reserve function that only become apparent during stress, when HFpEF patients typically become symptomatic11. (strokecenter.org)
- 4-6 Moreover, exercise training may in itself have deleterious effects on the failing myocardium, because of the presence of several intrinsic abnormalities susceptible to exercise induced sympathetic stimulation and consequent tachycardia. (bmj.com)
- In the cyclin D2 null mice, cardiac function was not impacted even though the hypertrophic response was blunted and a number of signaling pathways are differentially regulated by exercise. (elsevier.com)
- Thus, IGF-1 and exercise activates both IGF1R and IR in the heart, and IGF1R- and IR-mediated signals may serve redundant roles in the hypertrophic responses of the heart to exercise training. (elsevier.com)
- Objective: Assess hypertrophic response of the association of thyroid hormone and exercise in the rat heart. (bvsalud.org)
- However, although acute cardiovascular changes induced during BHD and fatal complicaitons by extreme diving have been studied, the long-term effects of shallow but frequent intermittent apnea by repetitive BHD have not been well studied. (biomedcentral.com)
- However, his exercise tolerance was well. (springer.com)
- Recent studies have shown unequivocally that exercise training for several months has beneficial effects on exercise tolerance, the autonomic nerve system, and the quality of life in patients with chronic heart failure. (bmj.com)
- The clinical features of the human syndrome such as cardiomegaly, lung and peripheral oedema and decreased exercise tolerance should be present. (edu.au)
- Change in sub-maximal exercise tolerance as evaluated using the Six Minute Walk test. (clinicaltrials.gov)
- He had experienced dyspnea, decreased exercise tolerance and dizziness for one month. (accjournal.org)
- Moreover, it has been reported that AASs can increase tolerance to exercise by making the muscles more capable to overload therefore shielding them from muscle fiber damage and improving the level of protein synthesis during recovery. (online-casino-player.info)
- Here we report a case of a 20-year-old woman with a history of exercise intolerance since childhood that was misinterpreted as asthma until a 2D-Echo revealed ALCAPA with RCA collaterals to the left anterior descending artery, preserved LV ejection fraction, and absence of apparent mitral valve abnormality. (hindawi.com)
- A 20-year-old woman presents with chronic dyspnea on exertion and exercise intolerance that was attributed to and treated as presumed exercise-induced asthma since childhood. (hindawi.com)
- Right ventriculo-arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance. (harvard.edu)
- A previously healthy African- American woman, aged 33 years, presented for urgent care with a three-week history of exercise and heat intolerance, dyspnea on exertion, chest pain, and a four-day history of lower-extremity edema and headaches. (ispub.com)
- Muscle phosphofructokinase (PFK) deficiency (Tarui's disease), or glycogen storage disease type 7 (GSD7), is a rare form of glycogen storage disease characterized by exertional fatigue and muscular exercise intolerance. (mendelian.co)
- The most common presenting complaints include exercise intolerance, as well as cough, dyspnea, and syncope. (vin.com)
- Also known as athletic bradycardia, or exercise-induced cardiomegaly, Athlete's heart is generally considered benign, but may occasionally hide a serious medical condition, or may even be mistaken for one. (sciblogs.co.nz)
- Voluntary apnea during breath-hold diving (BHD) induces cardiovascular changes including bradycardia, reduced cardiac output, and arterial hypertension. (biomedcentral.com)
- Intriguingly, IR tyrosine phosphorylation in the heart was also increased following IGF-1 administration or exercise training in control and CIGFRKO mice but not in CIRKO mice. (elsevier.com)
- Phosgene-induced leakage of fluid from capillaries into the pulmonary interstitium is normally opposed by lymphatic drainage from the parenchyma, but as the fluid leakage increases, normal drainage mechanisms become progressively overwhelmed. (fas.org)
- GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. (bmj.com)
- Any dyspnea on effort had not seen during out-patient clinic (NYHA I). Ventilation/perfusion lung scintigraphy was conducted to exclude aneurysm-induced compression of surrounding organs, but no significant findings were observed. (springer.com)
- Exercise capacity, lung congestion, maximal oxygen consumption, arterial oxygen saturation, and survivorship were all improved in the iPS-treated cohort, which was free of adverse effects on follow-up. (ahajournals.org)
- Platz E, Merz A, Silverman M, Lewis E, Groarke JD, Waxman A, Systrom D. Association between lung ultrasound findings and invasive exercise haemodynamics in patients with undifferentiated dyspnoea. (harvard.edu)
- The neuroprotective efficacy of induced hypothermia following or during ischemia of the brain is evident in experimental animal models of stroke [1 -1 1]. (google.com)
- 1. Ischemia induces opening of the blood-brain barrier, a process that seems to be very sensitive to brain temperature . (google.com)
- After intravenous anesthesia, his aneurysm occluded the left main bronchus and right pulmonary artery simultaneously, and induced severe hypoxia. (springer.com)
- Apnea, whether voluntary or involuntary, induces several physiological changes, which are a type of protective responses to hypoxia and involve potential health hazards as well. (biomedcentral.com)
- Obstructive sleep apnea (OSA) is a condition in which breathing stops involuntarily for a short time during sleep, has something in common with BHD in terms of the repeated exposure to intermittent apnea-induced hypoxia, even though it's pathophysiology is different from what of BHD. (biomedcentral.com)
- The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury by activating the cardiac renin-angiotensin-aldosterone system and downregulating KATP channel expression. (nih.gov)
- The athletes' ECG and the exercise related sudden cardiac death]. (cdc.gov)
- Objective To investigate the recovery process of exercise induced diastolic dysfunction in heart failure, using Doppler echocardiographic techniques. (bmj.com)
- Conclusions Exercise induced diastolic left ventricular dysfunction of the failing heart persists for 24 hours or more after exercise. (bmj.com)
- Diastolic ventricular function of the failing heart is reported to be impaired during exercise. (bmj.com)
- 13 We further showed that the exercise induced diastolic dysfunction is attenuated by β adrenoceptor blockade. (bmj.com)
- Moreover, the exercise induced diastolic dysfunction may persist despite cessation of exercise. (bmj.com)
- 15 Thus even a physiological sympathetic activation during exercise may cause a sustained diastolic dysfunction in the failing heart because of its susceptibility to sympathetic stimulation. (bmj.com)
- Thus to determine a safe and logical exercise programme for patients with chronic heart failure it is important to clarify how long exercise induced diastolic dysfunction persists. (bmj.com)
- Determine whether resting and exercise-induced increases in LV diastolic pressures are related to exaggerated right-left heart coupling and to increased afterload. (strokecenter.org)
- It is known that the glucocorticoid induced morphological changes are associated with cardiovascular risk factors such as high blood pressure, blood glucose and triglyceride levels, and low high density lipoprotein cholesterol levels, 6 and that many forms of lipodystrophy are associated with metabolic disorders and premature atherosclerosis. (bmj.com)
- The combination of high glucose and low insulin can induce oxidative stress , which impairs cell remodeling, particularly in the absence of normal scavenger levels. (stylesstar.com)
- At 100 days post-TAC, untreated K ATP channel-deficient hearts developed cardiomegaly, regional and global left ventricular systolic dysfunction, fulminant congestive heart failure and death. (ahajournals.org)
- 1 ] Right ventricular (RV) pacing can induce dyssynchronous contraction of the left ventricle (LV) and LV dysfunction. (accjournal.org)
- Thoracic radiography is not specific for pulmonary hypertension, but may demonstrate supportive findings, including cardiomegaly, right-sided heart enlargement, or pulmonary artery dilation. (vin.com)
- 1-3 However, exercise activates neurohumoral factors, reduces renal blood flow, and perhaps precipitates cardiac arrhythmias. (bmj.com)
- Mixed or variable threshold angina pectoris is a syndrome in which there is substantial variation in the magnitude of physical activity that induces anginal chest pain. (wikidoc.org)
- 7-12 Thus we cannot exclude the possibility that exercise training worsens long term prognosis in patients with chronic heart failure despite the short term benefits. (bmj.com)
- Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. (bvsalud.org)
- The present study evaluated whether blockade of angiotensin II receptor (AT1-R) with losartan and aldosterone receptor (mineralocorticoid receptor, MR) with spironolactone could prevent the deleterious effect of AAS on the exercise-induced cardioprotection. (nih.gov)
- By contrast, the exercise induced dyspnoea and orthopnoea progressed to the point where his capacity to perform activities of daily living was impaired. (bmj.com)
- Anaerobic exercise may be substituted for high-intensity muscular activity, particularly when blood flow is reduced and oxygen availability is limited. (medscape.com)
- Derived by nuclear reprogramming of somatic tissue, induced pluripotent stem (iPS) cells repair ischemic heart injury. (ahajournals.org)
- The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of a pharmaceutical composition comprising a neurotensin or a neurotensin analog or a synthetic neurotensin or a neurotensin receptor agonist, thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. (google.com)
- It contains two selenocysteine groups per molecule and is a major component of a redox system with a multiplicity of functions, among which is the capacity to degrade locally excessive and potentially toxic concentrations of peroxide and hydroperoxides likely to induce cell death and tissue atrophy ( 6 ). (fao.org)
- 4 This typical redistribution of the adipose tissue induced by glucocorticoids can be considered as an iatrogenic form of lipodystrophy. (bmj.com)
- In addition, the large areas of adrenergic denervation in the myocardium decrease the contractile reserve: an abnormal response to exercise in the presence of normal basal systolic function is a sign of incipient diabetic cardiomyopathy. (stylesstar.com)
- Phosphofructokinase (PFK) Deficiency: Autosomal recessive disorder causing chronic hemolysis and hemolytic crises, especially with exercise. (animalia-life.club)
- A chest radiograph revealed marked cardiomegaly and mediastinum expansion without a difference of increased radiolucency between the left and right lungs. (springer.com)
- An enlarged left ventricle could be caused by heart disease or harmless adaptation to sustained exercise, and these two conditions share overlapping features. (sciblogs.co.nz)
- There is general consensus that HFpEF patients have increased left ventricular filling pressures (LVDP) and relatively normal systolic function at rest5,8,10, but two critical questions remain: what causes the increase in LVDP, and, are there important deficits in the cardiovascular response to exercise stress in HFpEF patients3,4? (strokecenter.org)
- However, as dilatation progresses, left ventricular ejection fraction and stroke volume deteriorate during exercise and at rest, and finally pulmonary capillary wedge pressure increases and patients become symptomatic 1.5-3 years after the infarct. (ox.ac.uk)
- Critical care of the ottawa knee rules are the laboratory findings in adrenocortical insufficiency, follow-up and management of patients and those induced by drugs is most common staging system in the emergency department and released. (aaan.org)
- Consider conducting exercise stress tests for male FFs above the age of 45 years with two or more risk factors for CAD. (cdc.gov)
- Treatment with IGF-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the Ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor NF-ATc1. (nih.gov)
- Furthermore, as kidney function and cardiovascular disease are closely associated [ 16 - 18 ] and BHD induces cardiovascular changes, we hypothesize that renal impairment may be one of the potential long-term health risks of repetitive BHD. (biomedcentral.com)
- However, transitory increases of pulmonary artery pressure may occur during exacerbations, exercise and sleep. (ersjournals.com)
- Exercise induced significant cardiac growth in all mouse models except the cyclin D2 −/− mice. (elsevier.com)
- Exercise induced cardiac growth in all of the transgenic mice except for the mice deficient in cyclin D2. (elsevier.com)
- Testing this idea, the team found that they could, indeed, activate ERBB2 in mice for a short interval only following an induced heart attack and obtain nearly complete heart regeneration within several weeks. (labroots.com)