Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Exercise Test
Exercise Therapy
Hydrops Fetalis
Cardiomegaly, Exercise-Induced
Exercise
Exercise Tolerance
Jamaica
An island in the Greater Antilles in the West Indies. Its capital is Kingston. It was discovered in 1494 by Columbus and was a Spanish colony 1509-1655 until captured by the English. Its flourishing slave trade was abolished in the 19th century. It was a British colony 1655-1958 and a territory of the West Indies Federation 1958-62. It achieved full independence in 1962. The name is from the Arawak Xaymaca, rich in springs or land of springs. (From Webster's New Geographical Dictionary, 1988, p564 & Room, Brewer's Dictionary of Names, 1992, p267)
Radiography, Thoracic
Physical Exertion
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Arteriovenous Fistula
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
Pericardial Effusion
Chagas Cardiomyopathy
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Fetal Diseases
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Electrocardiography
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Ultrasonography, Prenatal
Echocardiography
Heart Neoplasms
Oxygen Consumption
Fatal Outcome
Physical Endurance
Heart Defects, Congenital
Myocardium
Muscle, Skeletal
Pregnancy
Bicycling
Hypertension
Physical Fitness
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Prognosis
Resistance Training
A type of strength-building exercise program that requires the body muscle to exert a force against some form of resistance, such as weight, stretch bands, water, or immovable objects. Resistance exercise is a combination of static and dynamic contractions involving shortening and lengthening of skeletal muscles.
Running
Anaerobic Threshold
The oxygen consumption level above which aerobic energy production is supplemented by anaerobic mechanisms during exercise, resulting in a sustained increase in lactate concentration and metabolic acidosis. The anaerobic threshold is affected by factors that modify oxygen delivery to the tissues; it is low in patients with heart disease. Methods of measurement include direct measure of lactate concentration, direct measurement of bicarbonate concentration, and gas exchange measurements.
Muscle Stretching Exercises
Exercises that stretch the muscle fibers with the aim to increase muscle-tendon FLEXIBILITY, improve RANGE OF MOTION or musculoskeletal function, and prevent injuries. There are various types of stretching techniques including active, passive (relaxed), static, dynamic (gentle), ballistic (forced), isometric, and others.
Pulmonary Gas Exchange
Lactic Acid
Breathing Exercises
Physical Education and Training
Asthma, Exercise-Induced
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Exercise Movement Techniques
Muscle Fatigue
A state arrived at through prolonged and strong contraction of a muscle. Studies in athletes during prolonged submaximal exercise have shown that muscle fatigue increases in almost direct proportion to the rate of muscle glycogen depletion. Muscle fatigue in short-term maximal exercise is associated with oxygen lack and an increased level of blood and muscle lactic acid, and an accompanying increase in hydrogen-ion concentration in the exercised muscle.
Adaptation, Physiological
Muscle Strength
Energy Metabolism
Cardiac Output
Hemodynamics
Walking
Sports
Respiration
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Ergometry
Muscle Contraction
Oxygen
Cardiovascular Physiological Phenomena
Analysis of Variance
Quadriceps Muscle
Treatment Outcome
Stroke Volume
Respiratory Function Tests
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Swimming
Body Weight
Sweating
Carbon Dioxide
Single-Blind Method
Phosphocreatine
Respiratory Mechanics
Isometric Contraction
Body Composition
Fatigue
Citrate (si)-Synthase
Aging
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Coronary Disease
Athletes
Quality of Life
Fatty Acids, Nonesterified
Plasma Volume
Physical Therapy Modalities
Dietary Carbohydrates
Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Reference Values
Double-Blind Method
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Follow-Up Studies
Body Temperature Regulation
Athletic Performance
Forced Expiratory Volume
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
Vascular Resistance
Pulmonary Disease, Chronic Obstructive
Recovery of Function
Ventricular Function, Left
Angina Pectoris
Hyperemia
Prospective Studies
Intermittent Claudication
Sedentary Lifestyle
Altitude
Blood Flow Velocity
Tai Ji
Muscle Proteins
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Hyperventilation
The incognita of the known: the athlete's heart syndrome. (1/17)
(+info)The prevalence, distribution, and clinical outcomes of electrocardiographic repolarization patterns in male athletes of African/Afro-Caribbean origin. (2/17)
(+info)Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants. (3/17)
(+info)Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy. (4/17)
(+info)Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise. (5/17)
(+info)Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. (6/17)
(+info)The endurance athletes heart: acute stress and chronic adaptation. (7/17)
(+info)Atrial fibrillation and atrial flutter in athletes. (8/17)
(+info)
Do big athletes have big hearts? Impact of extreme anthropometry upon cardiac hypertrophy in professional male athletes<...
miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury
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Exercise Intolerance in Renal Failure - Full Text View - ClinicalTrials.gov
Sleep disordered breathing tied to lower exercise capacity
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Journal of The Indian Academy of Echocardiography & Cardiovascular Imaging - Inverted Asymmetrical hypertrophy of left...
Gender specific regulation of physiological hypertrophy in mice in response to voluntary exercise - CLAHRC
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Athletes Heart - Cardiovascular Disorders - Merck Manuals Professional Edition
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Reduced ischemia and reperfusion injury following exercise training<...
Treadmill BP in Simulated Peripheral Artery Disease
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Palpitations
... induced by exercise could be suggestive of cardiomyopathy, ischemia or channelopathies. The most important initial ... Evidence of cardiomegaly and peripheral edema may indicate heart failure and ischemia or a valvular abnormality. Blood tests, ... Supraventricular tachycardias can also be induced at the termination of exercise when the withdrawal of catecholamines is ... Vagus nerve induced palpitation is felt as a thud, a hollow fluttery sensation, or a skipped beat, depending on at what point ...
Ventricular hypertrophy
It is not uncommon to undergo cardiopulmonary exercise testing (CPET), which measures the heart's response to exercise, to ... it is believed that the eccentric hypertrophy is induced by volume-overload and that the concentric hypertrophy is induced by ... Athletic heart syndrome Cardiac fibrosis Cardiology Cardiomegaly Cardiovascular disease Right ventricular hypertrophy ECG See ... It is a response to 'volume-overload', either as a result of increased blood return to the heart during exercise, or a response ...
Tafazzin
A patient with a frame shift mutation of c.227delC displayed symptoms of neutropenia, cardiomegaly, and other common symptoms ... Based on studies of cervical cancer progression, it is believed that TAZ may induce cancer by inhibiting apoptosis and ... November 2011). "Impaired cardiac reserve and severely diminished skeletal muscle O₂ utilization mediate exercise intolerance ... Another c.C153G mutation resulted in severe metabolic acidosis, cardiomegaly, and other major symptoms of Barth syndrome. There ...
Cardiovascular disease
Tentative evidence suggests that home-based exercise programs may be more efficient at improving exercise adherence. While a ... Cardiovascular late side-effects have been termed radiation-induced heart disease (RIHD) and radiation-induced vascular disease ... Inflammatory cardiomegaly Myocarditis - inflammation of the myocardium, the muscular part of the heart, caused most often by ... Insufficient physical activity (defined as less than 5 x 30 minutes of moderate activity per week, or less than 3 x 20 minutes ...
Incidents at Six Flags parks
The boy was put into a medically induced coma and taken to a hospital; there, he underwent head surgery, in which a portion of ... On January 5, 1996, two trainers were injured by cougars during an exercise session. One trainer was in the cougar enclosure to ... the coroner's report later stated that she died due to cardiomegaly, and had been seeing a cardiologist for treatment. On ...
Lyme disease
People with Lyme arthritis should limit their level of physical activity to avoid damaging affected joints, and in case of ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... In 10-15% of people, Lyme causes myocardial complications such as cardiomegaly, left ventricular dysfunction, or congestive ... Schneider BS, Schriefer ME, Dietrich G, Dolan MC, Morshed MG, Zeidner NS (October 2008). "Borrelia bissettii isolates induce ...
Heart failure with preserved ejection fraction
... manifestations of HFpEF are similar to those observed in HFrEF and include shortness of breath including exercise induced ... and is associated with improved aerobic exercise capacity.[50] The benefit patients seem to derive from exercise does not seem ... The former is the result of stress, such as exercise, while the latter is the result of reduced coronary flow.[citation needed] ... This is undertaken because perturbations in diastole are exaggerated during the increased demands of exercise. Exercise ...
Myocarditis
Shortness of breath, chest pain, decreased ability to exercise, irregular heartbeat[1]. ... decreased ability to exercise, and an irregular heartbeat.[1] The duration of problems can vary from hours to months.[1] ... A period of no exercise is typically recommended during recovery.[1][2] Corticosteroids or intravenous immunoglobulin (IVIG) ...
Atrial fibrillation
Long-term endurance exercise that far exceeds the recommended amount of exercise (e.g., long-distance cycling or marathon ... Finally, nicotine induces the formation of patterns of collagen type III in the atrium and has profibrotic effects. All this ... Exercise stress testing[edit]. Some individuals with atrial fibrillation do well with normal activity but develop shortness of ... Regular aerobic exercise improves atrial fibrillation symptoms and AF-related quality of life.[15] The effect of high-intensity ...
Tachycardia
This is the basis for the so-called fight-or-flight response, but such stimulation can also be induced by stimulants such as ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ... such as with exercise) or abnormal (such as with electrical problems within the heart). ...
Coronary artery disease
Medications and exercise are roughly equally effective.[64] High levels of physical activity reduce the risk of coronary artery ... Chronic high-grade narrowing of the coronary arteries can induce transient ischemia which leads to the induction of a ... Exercise; aerobic exercise, like walking, jogging, or swimming, can reduce the risk of mortality from coronary artery disease.[ ... Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease. Major Recommendations ...
AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in...
The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury by ... Nandrolone impaired the exercise-induced cardioprotection, but this effect was prevented by losartan (AT1-R antagonist) and ... AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in ... Conclusion: The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury ...
A case of cough and breathlessness | Thorax
By contrast, the exercise induced dyspnoea and orthopnoea progressed to the point where his capacity to perform activities of ... GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. Spirometry was normal (forced expiratory volume in ... His chest X-ray now showed cardiomegaly, blunted costophrenic angles and bilateral lower zone infiltrates. A further ... peripheral oedema and a reduction in exercise tolerance to approximately 10 m walking. Upper gastrointestinal endoscopy was ...
PPT - Atrial FIbrillation PowerPoint Presentation, free download - ID:2355873
AF-Additional Testing • May be indicated in some circumstances • Stress testing • If AF is exercise induced • To assess rate ... AF-Initial Workup • Chest X-ray • Cardiomegaly • Pulmonary disease • Blood work • Thyroid functions • BMP • Hepatic profile • ... AF-Goals of Therapy • Rate control • Most important initial strategy • Prevention of CHF (tachycardia induced cardiomyopathy ...
Fire Fighter Fatality Investigation Report F2004-30 | NIOSH | CDC
Use of Exercise Stress Tests (EST) to Screen for CAD. To reduce the risk of heart attacks and sudden cardiac arrest among FFs, ... Cardiomegaly (an enlarged heart) weighing 560 grams (normal is less than 400 grams)1 ... but his untimely death is much more likely due to an MI-induced heart arrhythmia. ... Consider conducting exercise stress tests for male FFs above the age of 45 years with two or more risk factors for CAD. ...
Fire Fighter Fatality Investigation Report F2012-11 | NIOSH | CDC
5) Exercise-induced ischemia or ventricular arrhythmias observed by radionuclide stress test during an evaluation reaching at ... Cardiomegaly (enlarged heart; heart weighed 660 grams [g]; predicted normal weight is 463 g [ranges between 351 g and 611 g as ... Health and Wellness Programs. The FD does not have a wellness/fitness program, and no exercise equipment is available in the ... 4) Maximal exercise tolerance of , 42 milliliters of oxygen per minute per kilogram or , 12 metabolic equivalents (METs) ...
ALCAPA Presents in an Adult with Exercise Intolerance but Preserved Cardiac Function
Here we report a case of a 20-year-old woman with a history of exercise intolerance since childhood that was misinterpreted as ... with chronic dyspnea on exertion and exercise intolerance that was attributed to and treated as presumed exercise-induced ... Chest X-ray showed no cardiomegaly (Supplemental Figure 2). Serial cardiac enzymes were negative. In the light of cardiac ... as exercise-induced asthma. The key for an early diagnosis before the occurrence of permanent cardiac damage is a careful ...
Hypothyroidism
... decreased exercise capacity and shortness of breath during exercise ■ ECG: low voltage of QRS complexes and P and T waves ■ CXR ... Clinical Manifestations of Hypothyroidism -- Cardiovascular System ■ Myxedema induces coronary artery disease ?? ■ CAD more ... cardiomegaly interstitial edema, myofibrillary swelling, LV dilatation, pericardial effusion * 11. ... and decreased exercise capacity impaired respiratory function + cardiovascular disease ■ Hypoventilation (shallow and slow ...
Hemodynamic collapse induced by general anesthesia in a patient with an unruptured thoracic aortic aneurysm: a case report |...
However, his exercise tolerance was well. Any dyspnea on effort had not seen during out-patient clinic (NYHA I). Ventilation/ ... A chest radiograph revealed marked cardiomegaly and mediastinum expansion without a difference of increased radiolucency ... Hemodynamic collapse induced by general anesthesia in a patient with an unruptured thoracic aortic aneurysm: a case report. ... Two cases of TAA-induced severe hypoxia with compression of the left main bronchus and right pulmonary artery have been ...
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Ethnic and Gender Specific Differences Among Athletes Participating in ECG Screening - American College of Cardiology
Cardiomegaly, Exercise-Induced, Cardiomyopathies, Coronary Vessels, Death, Sudden, Cardiac, Echocardiography, ... Clinical Topics: Arrhythmias and Clinical EP, Heart Failure and Cardiomyopathies, Noninvasive Imaging, Sports and Exercise ... Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise ... Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes. ...
Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non...
Exercise capacity, lung congestion, maximal oxygen consumption, arterial oxygen saturation, and survivorship were all improved ... Results: At 100 days post-TAC, untreated KATP channel-deficient hearts developed cardiomegaly, regional and global left ... Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non- ... Abstract 12573: Induced Pluripotent Stem Cells Treatment Prevent Heart Failure and Ventricular Dyssynchrony in Genetic Non- ...
WO2009071097A1 - Use of hypothermia inducing drugs
- Google Patents
... thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. ... Cardiomegaly is a medical condition wherein the heart is enlarged. It can often be associated with other serious medical ... lack of exercise and increasing average lifespan. The main causes of death and disability among cardiovascular diseases are ... WO2009071097A1 - Use of hypothermia inducing drugs - Google Patents. Use of hypothermia inducing drugs Download PDF Info. ...
Sciblogs | Your Fitbit could warn you about heart disease
Also known as athletic bradycardia, or exercise-induced cardiomegaly, Athletes heart is generally considered benign, but may ... Activity data from wearables may help us identify individuals more likely to have this condition due to exercise, and are ... "An enlarged left ventricle could be caused by heart disease or harmless adaptation to sustained exercise, and these two ...
Sustained left ventricular diastolic dysfunction after exercise in patients with dilated cardiomyopathy | Heart
Moreover, the exercise induced diastolic dysfunction may persist despite cessation of exercise. Kono et al reported that the ... 1963) Value of prolonged bed rest in management of cardiomegaly. JAMA 183:81-87. ... 1993) Effect of heart failure on the mechanism of exercise-induced augmentation of mitral valve flow. Circ Res 72:795-806. ... Conclusions Exercise induced diastolic left ventricular dysfunction of the failing heart persists for 24 hours or more after ...
Blood pressure and left ventricular hypertrophy during american-style football participation<...
IMSEAR at SEARO: Search
1 Cardiomegaly, Exercise-Induced. *1 Congenital heart defects. *1 Congenital heart disease ... No Synergic Effect of Sildenafil Administration on Exercise Capacity Improvement in a Fontan Patient with Regular Exercise ... Kindergarten Children with Congenital Heart Disease Show Good Physical Activity but Reduced Motor Skills in Comparison with ...
IMSEAR at SEARO: Search
Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy<...
We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ... We found that alterations in the signaling pathways tested here had no impact on exercise performance. Exercise induced cardiac ...
Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy<...
In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ... In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. Thus, IGF ...
Sudden cardiac death in athletes - PubMed
Search | Global Index Medicus
Exercise-Induced/genetics , Cardiomegaly/genetics , Exercise/physiology , MicroRNAs/physiology , Cardiomegaly, Exercise-Induced ... Animals , Male , Rats , Cardiomegaly, Exercise-Induced/drug effects , Cardiomegaly, Exercise-Induced/physiology , Heart/drug ... Humans , Atrial Fibrillation/etiology , Cardiomegaly, Exercise-Induced , Atrial Fibrillation/diagnosis , Cardiomegaly, Exercise ... There is no fibrosis and no cardiac dysfunction in eccentric or concentric hypertrophy induced by exercise training. Therefore ...
N-hydroxy-4-((4-(phenylthio)phenyl)sulfonyl)-1-(2-propynyl)-4-piperidinecarboxamide
- SC 276
Summary Report |...
Cardiomegaly (Heart Hypertrophy) 10/15/1987 - "Lactate dehydrogenase activity increased significantly (P less than 0.01) in ... These data indicate that (1) beta-adrenergic blockade prevents training-induced cardiac hypertrophy; (2) beta-antagonists have ... myocardium may increase its ability to utilize lactate during exercise with training despite beta 1-blockade.". ...
PRIME PubMed | Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy
Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy. Download Prime PubMed App to iPhone, iPad, or ... AndrogensAnimalsCardiomegalyFemaleGlucocorticoidsHeart VentriclesOrgan SizePhysical ExertionRatsRats, Inbred StrainsReceptors, ... Androgen cytosol binding in exercise-induced sparing of muscle atrophy.. *Glucocorticoid-induced cardiac hypertrophy: additive ... Androgen and glucocorticoid mechanisms in exercise-induced cardiac hypertrophy.. Am J Physiol. 1984 Jun; 246(6 Pt 2):H761-7.AJ ...
DeCS
CARDIOMEGALY, EXERCISE-INDUCED is also available. ... Cardiomegaly Entry term(s). Enlarged Heart Enlargement, Heart ... Cardiomegaly - Preferred Concept UI. M0009952. Scope note. Enlargement of the HEART, usually indicated by a cardiothoracic ... CI chemically induced. CL classification. CN congenital. CO complications. DG diagnostic imaging. DH diet therapy. DI diagnosis ... Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of ...
Search | Global Index Medicus
Animals , Male , Rats , Cardiomegaly, Exercise-Induced/drug effects , Cardiomegaly, Exercise-Induced/physiology , Heart/drug ... Objective: Assess hypertrophic response of the association of thyroid hormone and exercise in the rat heart. Methods: We used ... Conclusion: The association of thyroid hormone with high-intensity exercise produced cardiac hypertrophy, and generated a ... thyroid hormone and exercise (H + E); the group received daily hormone levothyroxine sodium by gavage at a dose of 20 μg ...
研究成果を検索
- 早稲田大学
Time course alterations of myocardial endothelin-1 production during the formation of exercise training-induced cardiac ... Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in ... Time dilation induced by object motion is based on spatiotopic but not retinotopic positions. Au, R. K. C., Ono, F. & Watanabe ... Time-dependent resonant UHF CI approach for the photo-induced dynamics of the multi-electron system confined in 2D QD. Okunishi ...
B. Merkely - Research Output
- Hungarian Consortium
Sex differences in morphological and functional aspects of exercise-induced cardiac hypertrophy in a rat model. Oláh, A., ... Characterization of the dynamic changes in left ventricular morphology and function induced by exercise training and detraining ... Relationship between Cardiac Remodeling and Exercise Capacity in Elite Athletes: Incremental Value of Left Atrial Morphology ... sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular ...
Ventricular Function | Harvard Catalyst Profiles | Harvard Catalyst
Hemodynamics | Harvard Catalyst Profiles | Harvard Catalyst
Endothelin-1
- Endothelin 1
Summary Report | CureHunter
... in marathoners with exercise induced hypertension compared to normotensive controls before and after running a marathon. ". 02/ ... Cardiomegaly (Heart Hypertrophy) 04/01/1996 - "These data suggest that blocking the action of endothelin-1 with a receptor ... 06/01/2013 - "Based on these studies, drugs that increase NO bioavailability, attenuate endothelin-1 induced pulmonary ... 01/2010 - "The purpose of this study was to determine the role of endothelin 1 in mediating sFlt-1-induced hypertension in ...
HypertrophyDilated cardiomyopathyMild cardiomegalyMyocardialVascularTachycardiaHypertrophicAcuteToleranceIntoleranceMetabolismAthlete'sBradycardiaPhosphorylationMechanismsLungIschemiaHypoxiaReninAthletesDiastolicGlucocorticoidImpairsDysfunctionHypertensionArrhythmiasSyndromeHeart FailureBlockadeDyspnoeaMuscularTissueMyocardiumChronicLeftFindingsStressActivatesRenalPulmonary arteryMice
Hypertrophy17
- Exercise studies were performed on females from six different genetic mouse models that have been shown to exhibit alterations in pathological cardiac adaptation and hypertrophy. (elsevier.com)
- Impact statement: This research is relevant as the hypertrophic signaling pathways tested here have only been characterized for their role in pathological hypertrophy, and not in the context of exercise or physiological hypertrophy. (elsevier.com)
- Given the potential overlap of insulin and IGF-1 signaling we sought to determine if both signaling pathways could contribute to exercise-induced cardiac hypertrophy following shorter-term exercise training. (elsevier.com)
- The extent of cardiac hypertrophy following exercise training in CIGFRKO and CIRKO mice was comparable to that in control mice. (elsevier.com)
- In contrast, exercise-induced cardiac hypertrophy was significantly attenuated in IGFR-/-IR+/- and IGFR+/-IR-/- mice. (elsevier.com)
- Conclusion: The association of thyroid hormone with high-intensity exercise produced cardiac hypertrophy, and generated a standard hypertrophy not directly correlated to the degree of fibrosis. (bvsalud.org)
- Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. (bvsalud.org)
- Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. (bvsalud.org)
- This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway involved, also showing that the cardiac markers of pathological hypertrophy (atrial natriuretic factor, β-myosin heavy chain and α-skeletal actin) are not increased. (bvsalud.org)
- There is no fibrosis and no cardiac dysfunction in eccentric or concentric hypertrophy induced by exercise training. (bvsalud.org)
- Here, we show that the angiotensin II type 1 (AT1) receptor is locally activated in pathological and physiological cardiac hypertrophy, although with exercise training it can be stimulated independently of the involvement of angiotensin II. (bvsalud.org)
- These findings show that glucocorticoids, rather than androgens, undergo adaptive changes in the circulation and in muscle during the development of exercise-induced cardiac hypertrophy. (unboundmedicine.com)
- When stressors that encourage this concentric hypertrophy are reduced or eliminated (either surgically corrected in the case of cardiac defects, or hypertension is reduced from diet and exercise) it is possible for the heart to undergo 'reverse remodeling', returning to a somewhat more 'normal' state instead of progressing to a dilated, pathologic phenotype. (wikipedia.org)
- Swimming exercise, which is not accompanied by Gq activation, induced a normal cardiac response, while Rgs2 deletion in Galphaq-overexpressing hearts exacerbated hypertrophy and dilation. (tamu.edu)
- This resulted in extreme cardiomyocyte proliferation and hypertrophy - excessive growth of the individual cardiomyocytes - leading to a giant heart (cardiomegaly) that left little room for blood to enter. (labroots.com)
- We propose that growth-factor-induced skeletal-muscle hypertrophy and changes in myofibre phenotype are mediated by calcium mobilization and are critically regulated by the calcineurin/NF-ATc1 signalling pathway. (nih.gov)
- Various aetiologies, in reaction to this, may induce compensatory mechanisms consisting of excentric (dilatation) and concentric hypertrophy. (ox.ac.uk)
Dilated cardiomyopathy6
- Design and patients Transmitral flow velocity profiles and standard non-invasive haemodynamic indices were obtained serially over seven days after symptom limited bicycle exercise tests in 18 patients with dilated cardiomyopathy and eight normal subjects. (bmj.com)
- Results The intensity of exercise, as assessed by respiratory gas analysis, was lower in patients with dilated cardiomyopathy than in normal subjects. (bmj.com)
- In contrast, patients with dilated cardiomyopathy showed a sustained decrease in the peak early diastolic filling velocity and a sustained increase in the deceleration time of early filling for 24 hours or more after exercise. (bmj.com)
- Because other haemodynamic variables recovered within one hour after exercise even in patients with dilated cardiomyopathy, the postexercise changes in ventricular filling were not explained by changes in loading conditions. (bmj.com)
- The efficacy of exercise training on a daily basis in dilated cardiomyopathy requires further evaluation. (bmj.com)
- In this study, we investigated the recovery process of the exercise induced diastolic left ventricular dysfunction in patients with dilated cardiomyopathy, using reproducible Doppler echocardiographic techniques. (bmj.com)
Mild cardiomegaly2
- Chest radiographs revealed mild cardiomegaly with a normal pulmonary vascular pattern. (ispub.com)
- A chest X-ray showed mild cardiomegaly ( Fig.1a ). (accjournal.org)
Myocardial6
- Myocardial tolerance to ischaemia/reperfusion (I/R) injury is improved by exercise training, but this cardioprotection is impaired by the chronic use of anabolic androgenic steroids (AAS). (nih.gov)
- 14 Because diastolic ventricular function is sensitive to transient myocardial metabolic insults, these findings suggest that exercise exerts a harmful metabolic effect on the failing myocardium through sympathetic stimulation. (bmj.com)
- If this is the case, the harmful metabolic effects may accumulate during exercise training or even during daily physical activities, promoting progression of myocardial failure. (bmj.com)
- and (3) while the training induction of myocardial hexokinase is inhibited by both beta 1- and beta 1 + beta 2-antagonists, myocardium may increase its ability to utilize lactate during exercise with training despite beta 1-blockade. (curehunter.com)
- Since mitochondria are responsible for the production of ATP, agents that interfere with the physiological myocardial mitochondrial function are expected to induce depletion of ATP pool. (southlaketimes.com)
- In these patients, bosentan was effective and was found to decrease vascular remodeling in induced pulmonary hypertension, improve myocardial function, and decrease ventricular remodeling. (vin.com)
Vascular5
- These oral medications have been shown to improve exercise intolerance, pulmonary arterial pressure, and even pulmonary vascular resistance in people. (vin.com)
- A, treatment is shorter act- ing exercise-induced and renin influ- ences vascular smooth muscle. (st-systemtronic.com)
- It is virtually totally excreted balance of vascular spasm of warfarin metabolism and cardiomegaly. (st-systemtronic.com)
- Trauma-associated dissections most frequently diagnosed viriga pills in a patient present with cardiomegaly, vascular congestion, or tenderness. (dvas.org)
- LV systolic, diastolic, and vascular function will be examined at rest and during graded supine exercise at fixed and varied preload to definitively characterize both baseline differences and discrepancies in cardiovascular reserve function that only become apparent during stress, when HFpEF patients typically become symptomatic11. (strokecenter.org)
Tachycardia1
- 4-6 Moreover, exercise training may in itself have deleterious effects on the failing myocardium, because of the presence of several intrinsic abnormalities susceptible to exercise induced sympathetic stimulation and consequent tachycardia. (bmj.com)
Hypertrophic3
- In the cyclin D2 null mice, cardiac function was not impacted even though the hypertrophic response was blunted and a number of signaling pathways are differentially regulated by exercise. (elsevier.com)
- Thus, IGF-1 and exercise activates both IGF1R and IR in the heart, and IGF1R- and IR-mediated signals may serve redundant roles in the hypertrophic responses of the heart to exercise training. (elsevier.com)
- Objective: Assess hypertrophic response of the association of thyroid hormone and exercise in the rat heart. (bvsalud.org)
Acute1
- However, although acute cardiovascular changes induced during BHD and fatal complicaitons by extreme diving have been studied, the long-term effects of shallow but frequent intermittent apnea by repetitive BHD have not been well studied. (biomedcentral.com)
Tolerance6
- However, his exercise tolerance was well. (springer.com)
- Recent studies have shown unequivocally that exercise training for several months has beneficial effects on exercise tolerance, the autonomic nerve system, and the quality of life in patients with chronic heart failure. (bmj.com)
- The clinical features of the human syndrome such as cardiomegaly, lung and peripheral oedema and decreased exercise tolerance should be present. (edu.au)
- Change in sub-maximal exercise tolerance as evaluated using the Six Minute Walk test. (clinicaltrials.gov)
- He had experienced dyspnea, decreased exercise tolerance and dizziness for one month. (accjournal.org)
- Moreover, it has been reported that AASs can increase tolerance to exercise by making the muscles more capable to overload therefore shielding them from muscle fiber damage and improving the level of protein synthesis during recovery. (online-casino-player.info)
Intolerance6
- Here we report a case of a 20-year-old woman with a history of exercise intolerance since childhood that was misinterpreted as asthma until a 2D-Echo revealed ALCAPA with RCA collaterals to the left anterior descending artery, preserved LV ejection fraction, and absence of apparent mitral valve abnormality. (hindawi.com)
- A 20-year-old woman presents with chronic dyspnea on exertion and exercise intolerance that was attributed to and treated as presumed exercise-induced asthma since childhood. (hindawi.com)
- Right ventriculo-arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance. (harvard.edu)
- A previously healthy African- American woman, aged 33 years, presented for urgent care with a three-week history of exercise and heat intolerance, dyspnea on exertion, chest pain, and a four-day history of lower-extremity edema and headaches. (ispub.com)
- Muscle phosphofructokinase (PFK) deficiency (Tarui's disease), or glycogen storage disease type 7 (GSD7), is a rare form of glycogen storage disease characterized by exertional fatigue and muscular exercise intolerance. (mendelian.co)
- The most common presenting complaints include exercise intolerance, as well as cough, dyspnea, and syncope. (vin.com)
Metabolism2
- Glycogen metabolism: Aerobic exercise is essential for intermittent or submaximal contraction. (medscape.com)
- Lipid metabolism: Lipid is an important source of energy in sustained submaximal exercise (ie, exercise lasting longer than 40 min). (medscape.com)
Athlete's1
- Also known as athletic bradycardia, or exercise-induced cardiomegaly, Athlete's heart is generally considered benign, but may occasionally hide a serious medical condition, or may even be mistaken for one. (sciblogs.co.nz)
Bradycardia1
- Voluntary apnea during breath-hold diving (BHD) induces cardiovascular changes including bradycardia, reduced cardiac output, and arterial hypertension. (biomedcentral.com)
Phosphorylation1
- Intriguingly, IR tyrosine phosphorylation in the heart was also increased following IGF-1 administration or exercise training in control and CIGFRKO mice but not in CIRKO mice. (elsevier.com)
Mechanisms1
- Phosgene-induced leakage of fluid from capillaries into the pulmonary interstitium is normally opposed by lymphatic drainage from the parenchyma, but as the fluid leakage increases, normal drainage mechanisms become progressively overwhelmed. (fas.org)
Lung4
- GE: Chest radiograph was normal with no cardiomegaly and normal lung fields. (bmj.com)
- Any dyspnea on effort had not seen during out-patient clinic (NYHA I). Ventilation/perfusion lung scintigraphy was conducted to exclude aneurysm-induced compression of surrounding organs, but no significant findings were observed. (springer.com)
- Exercise capacity, lung congestion, maximal oxygen consumption, arterial oxygen saturation, and survivorship were all improved in the iPS-treated cohort, which was free of adverse effects on follow-up. (ahajournals.org)
- Platz E, Merz A, Silverman M, Lewis E, Groarke JD, Waxman A, Systrom D. Association between lung ultrasound findings and invasive exercise haemodynamics in patients with undifferentiated dyspnoea. (harvard.edu)
Ischemia2
- The neuroprotective efficacy of induced hypothermia following or during ischemia of the brain is evident in experimental animal models of stroke [1 -1 1]. (google.com)
- 1. Ischemia induces opening of the blood-brain barrier, a process that seems to be very sensitive to brain temperature [15]. (google.com)
Hypoxia3
- After intravenous anesthesia, his aneurysm occluded the left main bronchus and right pulmonary artery simultaneously, and induced severe hypoxia. (springer.com)
- Apnea, whether voluntary or involuntary, induces several physiological changes, which are a type of protective responses to hypoxia and involve potential health hazards as well. (biomedcentral.com)
- Obstructive sleep apnea (OSA) is a condition in which breathing stops involuntarily for a short time during sleep, has something in common with BHD in terms of the repeated exposure to intermittent apnea-induced hypoxia, even though it's pathophysiology is different from what of BHD. (biomedcentral.com)
Renin1
- The chronic nandrolone treatment impairs the exercise-induced cardioprotection against ischaemia/reperfusion injury by activating the cardiac renin-angiotensin-aldosterone system and downregulating KATP channel expression. (nih.gov)
Athletes1
- The athletes' ECG and the exercise related sudden cardiac death]. (cdc.gov)
Diastolic8
- Objective To investigate the recovery process of exercise induced diastolic dysfunction in heart failure, using Doppler echocardiographic techniques. (bmj.com)
- Conclusions Exercise induced diastolic left ventricular dysfunction of the failing heart persists for 24 hours or more after exercise. (bmj.com)
- Diastolic ventricular function of the failing heart is reported to be impaired during exercise. (bmj.com)
- 13 We further showed that the exercise induced diastolic dysfunction is attenuated by β adrenoceptor blockade. (bmj.com)
- Moreover, the exercise induced diastolic dysfunction may persist despite cessation of exercise. (bmj.com)
- 15 Thus even a physiological sympathetic activation during exercise may cause a sustained diastolic dysfunction in the failing heart because of its susceptibility to sympathetic stimulation. (bmj.com)
- Thus to determine a safe and logical exercise programme for patients with chronic heart failure it is important to clarify how long exercise induced diastolic dysfunction persists. (bmj.com)
- Determine whether resting and exercise-induced increases in LV diastolic pressures are related to exaggerated right-left heart coupling and to increased afterload. (strokecenter.org)
Glucocorticoid1
- It is known that the glucocorticoid induced morphological changes are associated with cardiovascular risk factors such as high blood pressure, blood glucose and triglyceride levels, and low high density lipoprotein cholesterol levels, 6 and that many forms of lipodystrophy are associated with metabolic disorders and premature atherosclerosis. (bmj.com)
Impairs1
- The combination of high glucose and low insulin can induce oxidative stress , which impairs cell remodeling, particularly in the absence of normal scavenger levels. (stylesstar.com)
Dysfunction2
- At 100 days post-TAC, untreated K ATP channel-deficient hearts developed cardiomegaly, regional and global left ventricular systolic dysfunction, fulminant congestive heart failure and death. (ahajournals.org)
- 1 ] Right ventricular (RV) pacing can induce dyssynchronous contraction of the left ventricle (LV) and LV dysfunction. (accjournal.org)
Hypertension1
- Thoracic radiography is not specific for pulmonary hypertension, but may demonstrate supportive findings, including cardiomegaly, right-sided heart enlargement, or pulmonary artery dilation. (vin.com)
Arrhythmias1
- 1-3 However, exercise activates neurohumoral factors, reduces renal blood flow, and perhaps precipitates cardiac arrhythmias. (bmj.com)
Syndrome1
- Mixed or variable threshold angina pectoris is a syndrome in which there is substantial variation in the magnitude of physical activity that induces anginal chest pain. (wikidoc.org)
Heart Failure2
- 7-12 Thus we cannot exclude the possibility that exercise training worsens long term prognosis in patients with chronic heart failure despite the short term benefits. (bmj.com)
- Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. (bvsalud.org)
Blockade1
- The present study evaluated whether blockade of angiotensin II receptor (AT1-R) with losartan and aldosterone receptor (mineralocorticoid receptor, MR) with spironolactone could prevent the deleterious effect of AAS on the exercise-induced cardioprotection. (nih.gov)
Dyspnoea1
- By contrast, the exercise induced dyspnoea and orthopnoea progressed to the point where his capacity to perform activities of daily living was impaired. (bmj.com)
Muscular1
- Anaerobic exercise may be substituted for high-intensity muscular activity, particularly when blood flow is reduced and oxygen availability is limited. (medscape.com)
Tissue4
- Derived by nuclear reprogramming of somatic tissue, induced pluripotent stem (iPS) cells repair ischemic heart injury. (ahajournals.org)
- The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of a pharmaceutical composition comprising a neurotensin or a neurotensin analog or a synthetic neurotensin or a neurotensin receptor agonist, thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. (google.com)
- It contains two selenocysteine groups per molecule and is a major component of a redox system with a multiplicity of functions, among which is the capacity to degrade locally excessive and potentially toxic concentrations of peroxide and hydroperoxides likely to induce cell death and tissue atrophy ( 6 ). (fao.org)
- 4 This typical redistribution of the adipose tissue induced by glucocorticoids can be considered as an iatrogenic form of lipodystrophy. (bmj.com)
Myocardium1
- In addition, the large areas of adrenergic denervation in the myocardium decrease the contractile reserve: an abnormal response to exercise in the presence of normal basal systolic function is a sign of incipient diabetic cardiomyopathy. (stylesstar.com)
Chronic1
- Phosphofructokinase (PFK) Deficiency: Autosomal recessive disorder causing chronic hemolysis and hemolytic crises, especially with exercise. (animalia-life.club)
Left4
- A chest radiograph revealed marked cardiomegaly and mediastinum expansion without a difference of increased radiolucency between the left and right lungs. (springer.com)
- An enlarged left ventricle could be caused by heart disease or harmless adaptation to sustained exercise, and these two conditions share overlapping features. (sciblogs.co.nz)
- There is general consensus that HFpEF patients have increased left ventricular filling pressures (LVDP) and relatively normal systolic function at rest5,8,10, but two critical questions remain: what causes the increase in LVDP, and, are there important deficits in the cardiovascular response to exercise stress in HFpEF patients3,4? (strokecenter.org)
- However, as dilatation progresses, left ventricular ejection fraction and stroke volume deteriorate during exercise and at rest, and finally pulmonary capillary wedge pressure increases and patients become symptomatic 1.5-3 years after the infarct. (ox.ac.uk)
Findings1
- Critical care of the ottawa knee rules are the laboratory findings in adrenocortical insufficiency, follow-up and management of patients and those induced by drugs is most common staging system in the emergency department and released. (aaan.org)
Stress1
- Consider conducting exercise stress tests for male FFs above the age of 45 years with two or more risk factors for CAD. (cdc.gov)
Activates1
- Treatment with IGF-1 or insulin and dexamethasone mobilizes intracellular calcium, activates the Ca2+/calmodulin-dependent phosphatase calcineurin, and induces the nuclear translocation of the transcription factor NF-ATc1. (nih.gov)
Renal1
- Furthermore, as kidney function and cardiovascular disease are closely associated [ 16 - 18 ] and BHD induces cardiovascular changes, we hypothesize that renal impairment may be one of the potential long-term health risks of repetitive BHD. (biomedcentral.com)
Pulmonary artery1
- However, transitory increases of pulmonary artery pressure may occur during exacerbations, exercise and sleep. (ersjournals.com)
Mice3
- Exercise induced significant cardiac growth in all mouse models except the cyclin D2 −/− mice. (elsevier.com)
- Exercise induced cardiac growth in all of the transgenic mice except for the mice deficient in cyclin D2. (elsevier.com)
- Testing this idea, the team found that they could, indeed, activate ERBB2 in mice for a short interval only following an induced heart attack and obtain nearly complete heart regeneration within several weeks. (labroots.com)