AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
CardiomegalyHydrops FetalisCardiomegaly, Exercise-InducedJamaicaRadiography, ThoracicCardiomyopathiesArteriovenous FistulaPericardial EffusionChagas CardiomyopathyFetal DiseasesUltrasonography, PrenatalHeart NeoplasmsHeart FailureFatal OutcomeElectrocardiographyEchocardiographyHeart Defects, CongenitalMyocardiumPregnancyRetrospective StudiesInfant, NewbornHypertensionPrognosisStudentsNursesEncyclopedias as TopicRisk FactorsMedical Missions, OfficialNaval MedicineFractures, CompressionVertebroplastyPleural EffusionPulmonary AtelectasisSpinal Cord CompressionAnemiaPercussionPulmonary Disease, Chronic ObstructiveDyspneaInternal MedicineThoracic Surgical ProceduresDyspnea, ParoxysmalAngina PectorisLymphedemaVirus DiseasesWorkloadHeartTerminology as TopicCopyrightDictionaries, MedicalDictionaries as TopicNigeriaDictionaries, ChemicalDiagnostic and Statistical Manual of Mental Disorders
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Hydrops Fetalis
Abnormal accumulation of serous fluid in two or more fetal compartments, such as SKIN; PLEURA; PERICARDIUM; PLACENTA; PERITONEUM; AMNIOTIC FLUID. General fetal EDEMA may be of non-immunologic origin, or of immunologic origin as in the case of ERYTHROBLASTOSIS FETALIS.
Cardiomegaly, Exercise-Induced
Heart enlargement and other remodeling in cardiac morphology and electrical circutry found in individuals who participate in intense repeated exercises.
Jamaica
An island in the Greater Antilles in the West Indies. Its capital is Kingston. It was discovered in 1494 by Columbus and was a Spanish colony 1509-1655 until captured by the English. Its flourishing slave trade was abolished in the 19th century. It was a British colony 1655-1958 and a territory of the West Indies Federation 1958-62. It achieved full independence in 1962. The name is from the Arawak Xaymaca, rich in springs or land of springs. (From Webster's New Geographical Dictionary, 1988, p564 & Room, Brewer's Dictionary of Names, 1992, p267)
Radiography, Thoracic
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Cardiomyopathies
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Arteriovenous Fistula
An abnormal direct communication between an artery and a vein without passing through the CAPILLARIES. An A-V fistula usually leads to the formation of a dilated sac-like connection, arteriovenous aneurysm. The locations and size of the shunts determine the degree of effects on the cardiovascular functions such as BLOOD PRESSURE and HEART RATE.
Pericardial Effusion
Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
Chagas Cardiomyopathy
A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.
Fetal Diseases
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
Ultrasonography, Prenatal
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Heart Neoplasms
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Fatal Outcome
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Electrocardiography
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
Echocardiography
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Heart Defects, Congenital
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Myocardium
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Infant, Newborn
An infant during the first month after birth.
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Prognosis
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Students
Individuals enrolled in a school or formal educational program.
Nurses
Professionals qualified by graduation from an accredited school of nursing and by passage of a national licensing examination to practice nursing. They provide services to patients requiring assistance in recovering or maintaining their physical or mental health.
Encyclopedias as Topic
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Risk Factors
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Medical Missions, Official
Travel by a group of physicians for the purpose of making a special study or undertaking a special project of short-term duration.
Naval Medicine
The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.
Fractures, Compression
Crumbling or smashing of cancellous BONE by forces acting parallel to the long axis of bone. It is applied particularly to vertebral body fractures (SPINAL FRACTURES). (Blauvelt and Nelson, A Manual of Orthopedic Terminology, 1994, p4)
Vertebroplasty
Procedures to repair or stabilize vertebral fractures, especially compression fractures accomplished by injecting BONE CEMENTS into the fractured VERTEBRAE.
Pleural Effusion
Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Pulmonary Atelectasis
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Spinal Cord Compression
Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Anemia
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Percussion
Act of striking a part with short, sharp blows as an aid in diagnosing the condition beneath the sound obtained.
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
Dyspnea
Difficult or labored breathing.
Internal Medicine
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
Thoracic Surgical Procedures
Surgery performed on the thoracic organs, most commonly the lungs and the heart.
Dyspnea, Paroxysmal
A disorder characterized by sudden attacks of respiratory distress in at rest patients with HEART FAILURE and PULMONARY EDEMA. It usually occurs at night after several hours of sleep in a reclining position. Patients awaken with a feeling of suffocation, coughing, a cold sweat, and TACHYCARDIA. When there is significant WHEEZING, it is called cardiac asthma.
Angina Pectoris
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Lymphedema
Edema due to obstruction of lymph vessels or disorders of the lymph nodes.
Virus Diseases
A general term for diseases produced by viruses.
Workload
The total amount of work to be performed by an individual, a department, or other group of workers in a period of time.
Heart
The hollow, muscular organ that maintains the circulation of the blood.
Terminology as Topic
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Copyright
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Nigeria
A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
Dictionaries, Chemical
Diagnostic and Statistical Manual of Mental Disorders
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)

Gender-related differences in myocyte remodeling in progression to heart failure. (1/3277)

Gender-related differences responsible for the better prognosis of females with heart failure have not been clearly established. To address this issue, we investigated potential gender-related differences in myocyte remodeling in spontaneously hypertensive heart failure rats. Echocardiograms and myocyte growth were compared between males and females at compensated (2, 4, and 6 months) and decompensated (18 months in males and 24 months in females) stages of cardiac hypertrophy. Although left ventricular diastolic dimensions did not differ significantly between failing male and female rats, fractional shortening declined significantly only in failing males. Myocyte cross-sectional area did not change after 4 months of age in both genders, which is likely to be responsible for the absence of a change in left ventricular wall thickness during the progression to heart failure. Myocyte volume and cross-sectional area were significantly larger in males than females at 2, 4, and 6 months of age, although there were no significant differences at the failing stage. Reduced adaptive hypertrophic reserve was observed in males, which is likely to contribute to the higher morbidity and mortality of males with chronic heart failure.  (+info)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (2/3277)

The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of L-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of L-carnitine administration in JVS mice.  (+info)

Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks. (3/3277)

To investigate the cellular mechanisms for altered Ca2+ homeostasis and contractility in cardiac hypertrophy, we measured whole-cell L-type Ca2+ currents (ICa,L), whole-cell Ca2+ transients ([Ca2+]i), and Ca2+ sparks in ventricular cells from 6-month-old spontaneously hypertensive rats (SHRs) and from age- and sex-matched Wistar-Kyoto and Sprague-Dawley control rats. By echocardiography, SHR hearts had cardiac hypertrophy and enhanced contractility (increased fractional shortening) and no signs of heart failure. SHR cells had a voltage-dependent increase in peak [Ca2+]i amplitude (at 0 mV, 1330+/-62 nmol/L [SHRs] versus 836+/-48 nmol/L [controls], P<0.05) that was not associated with changes in ICa,L density or kinetics, resting [Ca2+]i, or Ca2+ content of the sarcoplasmic reticulum (SR). SHR cells had increased time of relaxation. Ca2+ sparks from SHR cells had larger average amplitudes (173+/-192 nmol/L [SHRs] versus 109+/-64 nmol/L [control]; P<0.05), which was due to redistribution of Ca2+ sparks to a larger amplitude population. This change in Ca2+ spark amplitude distribution was not associated with any change in the density of ryanodine receptors, calsequestrin, junctin, triadin 1, Ca2+-ATPase, or phospholamban. Therefore, SHRs with cardiac hypertrophy have increased contractility, [Ca2+]i amplitude, time to relaxation, and average Ca2+ spark amplitude ("big sparks"). Importantly, big sparks occurred without alteration in the trigger for SR Ca2+ release (ICa,L), SR Ca2+ content, or the expression of several SR Ca2+-cycling proteins. Thus, cardiac hypertrophy in SHRs is linked with an alteration in the coupling of Ca2+ entry through L-type Ca2+ channels and the release of Ca2+ from the SR, leading to big sparks and enhanced contractility. Alterations in the microdomain between L-type Ca2+ channels and SR Ca2+ release channels may underlie the changes in Ca2+ homeostasis observed in cardiac hypertrophy. Modulation of SR Ca2+ release may provide a new therapeutic strategy for cardiac hypertrophy and for its progression to heart failure and sudden death.  (+info)

Rho family small G proteins play critical roles in mechanical stress-induced hypertrophic responses in cardiac myocytes. (4/3277)

-Mechanical stress induces a variety of hypertrophic responses, such as activation of protein kinases, reprogramming of gene expression, and an increase in protein synthesis. In the present study, to elucidate how mechanical stress induces such events, we examined the role of Rho family small GTP-binding proteins (G proteins) in mechanical stress-induced cardiac hypertrophy. Treatment of neonatal rat cardiomyocytes with the C3 exoenzyme, which abrogates Rho functions, suppressed stretch-induced activation of extracellular signal-regulated protein kinases (ERKs). Overexpression of the Rho GDP dissociation inhibitor (Rho-GDI), dominant-negative mutants of RhoA (DNRhoA), or DNRac1 significantly inhibited stretch-induced activation of transfected ERK2. Overexpression of constitutively active mutants of RhoA slightly activated ERK2 in cardiac myocytes. Overexpression of C-terminal Src kinase, which inhibits functions of the Src family of tyrosine kinases, or overexpression of DNRas had no effect on stretch-induced activation of transfected ERK2. The promoter activity of skeletal alpha-actin and c-fos genes was increased by stretch, and these increases were completely inhibited by either cotransfection of Rho-GDI or pretreatment with C3 exoenzyme. Mechanical stretch increased phenylalanine incorporation into cardiac myocytes by approximately 1.5-fold compared with control, and this increase was also significantly suppressed by pretreatment with C3 exoenzyme. Overexpression of Rho-GDI or DNRhoA did not affect angiotensin II-induced activation of ERK. ERKs were activated by culture media conditioned by stretch of cardiomyocytes without any treatment, but not of cardiomyocytes with pretreatment by C3 exoenzyme. These results suggest that the Rho family of small G proteins plays critical roles in mechanical stress-induced hypertrophic responses.  (+info)

TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin. (5/3277)

Differential display identified that gene fragment HA220 homologous to the transcriptional activator factor II 250 (TAFII250) gene, or CCG1, was increased in hypertrophied rodent heart. To determine whether TAFII250 gene expression is modified after cardiac damage, we measured TAFII250 expression in vivo in mouse hearts after injection of the cardiotoxic agent doxorubicin (DXR) and in vitro in DXR-treated isolated rat neonatal cardiomyocytes. In vivo atrial natriuretic factor (ANF), beta-myosin heavy chain (beta-MHC), Egr-1, and TAFII250 expression increased with dose and time after a single DXR injection, but only ANF and beta-MHC expression were increased after multiple injections. After DXR treatment of neonatal cardiomyocytes we found decreased ANF, alpha-MHC, Egr-1, and TAFII250 expression. Expression of the TAFII250-regulated genes, the D-type cyclins, was increased after a single injection in adult mice and was decreased in DXR-treated cardiomyocytes. Thus expression of Erg-1, TAFII250, and the D-type cyclins is modulated after cardiotoxic damage in adult and neonatal heart.  (+info)

Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. (6/3277)

AIM: To develop a cardiac hypertrophic model in rats. METHODS: Rats were i.p. levothyroxine 0.5 mg.kg-1.d-1 x 10 d. The action potentials of right papillary muscles were recorded by standard glass-microelectrode technique. The left coronary artery was ligated followed by reperfusion and the apparent infarcted zone (AIZ) was determined by tetracycline fluoresence, and the superoxide dismutase (SOD) activity and malondialdehyde (MDA) product in myocardium were also measured. RESULTS: In the rats treated by levothyroxine, the heart was hypertrophic and the action potential duration (APD) and effective refractory period (ERP) were prolonged, the APD20, APD50, APD90, and ERP were prolonged by 80%, 79%, 74%, and 68%, respectively. No changes in resting potential (RP), action potential amplitude (APA), and Vmax were produced. The incidence of heart arrest (8/8) and the risk of death (67 +/- 0) induced by ischemia-reperfusion in rats with hypertrophic heart was higher than those in normal rats (4/10 and 44 +/- 19, respectively). The AIZ was expanded markedly in hypertrophic heart, and attenuated by lidocaine and propranolol. CONCLUSION: Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats.  (+info)

A case of eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. (7/3277)

This report describes a patient with eosinophilic myocarditis complicated by Kimura's disease (eosinophilic hyperplastic lymphogranuloma) and erythroderma. A 50-year-old man presented with a complaint of precordial pain. However, the only abnormal finding on examinatioin was eosinophilia (1617 eosinophils/microl). Three years later, the patient developed chronic eczema, and was diagnosed with erythroderma posteczematosa. One year later, a tumor was detected in the right auricule, and a diagnosis of Kimura's disease was made, based on the biopsy findings. The patient developed progressive dyspnea 6 months later and was found to have cardiomegaly and a depressed left ventricular ejection fraction (17%). A diagnosis of eosinophilic myocarditis was made based on the results of a right ventricular endomyocardial biopsy. The eosinophilic myocarditis and erythrodrema were treated with steroids with improvement of both the eosinophilia and left ventricular function.  (+info)

Transcriptional activation of the glucose transporter GLUT1 in ventricular cardiac myocytes by hypertrophic agonists. (8/3277)

Myocardial hypertrophy is associated with increased basal glucose metabolism. Basal glucose transport into cardiac myocytes is mediated by the GLUT1 isoform of glucose transporters, whereas the GLUT4 isoform is responsible for regulatable glucose transport. Treatment of neonatal cardiac myocytes with the hypertrophic agonist 12-O-tetradecanoylphorbol-13-acetate or phenylephrine increased expression of Glut1 mRNA relative to Glut4 mRNA. To study the transcriptional regulation of GLUT1 expression, myocytes were transfected with luciferase reporter constructs under the control of the Glut1 promoter. Stimulation of the cells with 12-O-tetradecanoylphorbol-13-acetate or phenylephrine induced transcription from the Glut1 promoter, which was inhibited by cotransfection with the mitogen-activated protein kinase phosphatases CL100 and MKP-3. Cotransfection of the myocytes with constitutively active versions of Ras and MEK1 or an estrogen-inducible version of Raf1 also stimulated transcription from the Glut1 promoter. Hypertrophic induction of the Glut1 promoter was also partially sensitive to inhibition of the phosphatidylinositol 3-kinase pathway and was strongly inhibited by cotransfection with dominant-negative Ras. Thus, Ras activation and pathways downstream of Ras mediate induction of the Glut1 promoter during myocardial hypertrophy.  (+info)

Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy | JCBMicrotubule Stabilization in Pressure Overload Cardiac Hypertrophy | JCB
The cardiocyte contractile dysfunction characteristic of pressure overload cardiac hypertrophy is accounted for to a remarkable degree by increased density of the cellular microtubule network (Tsutsui et al., 1993, 1994), which imposes a primarily viscous load on active myofilaments; that is, structural damping via intracellular frictional dissipation that impedes sarcomere shortening (Tagawa et al., 1997). This is accompanied by persistent increases in α- and β-tubulin on both the mRNA and protein levels (Tagawa et al., 1996). Thus, increased synthesis of αβ-tubulin heterodimers, effecting in turn microtubule formation, is one apparent cause for this greater microtubule density. Given, however, that the αβ-tubulin heterodimer-microtubule system is in dynamic equilibrium, enhanced microtubule stability is a second, and potentially synergistic, candidate mechanism for augmented microtubule density. This study was designed to evaluate this second potential mechanism.. The restriction of the ...
http://jcb.rupress.org/content/139/4/963
Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction...Mineralocorticoid Receptor Deficiency in T Cells Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction...
Although functions of MR in several other cell types have been elucidated in pathologic cardiac hypertrophy and heart failure,15-17,19,36-38 the roles of MR in T cells have not been illuminated. Through this study, we demonstrated that eplerenone and TMRKO attenuated POL-induced cardiac remodeling and dysfunction in parallel with attenuated cardiac inflammation, as well as decreased T-cell accumulation and activation in the heart. Moreover, in vitro results illustrated direct regulation of T-cell activation by MR.. This study implies that MR blockade in T cells is a feasible approach to treat pathologic cardiac hypertrophy and heart failure. MR deficiency in T cells was sufficient to suppress POL-induced cardiac hypertrophy, cardiac fibrosis, and cardiac dysfunction, as well as cardiac inflammation in mice. Particularly, TMRKO completely abrogated parts of the phenotype 1 week after POL, indicating that MR in T cells may be more important than MR in other cellular compartments in the early stage ...
http://hyper.ahajournals.org/content/70/1/137
c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function...c-Myc alters substrate utilization and O-GlcNAc protein posttranslational modifications without altering cardiac function...
The protooncogene C-Myc (Myc) regulates cardiac hypertrophy. Myc promotes compensated cardiac function, suggesting that the operative mechanisms differ from those leading to heart failure. Myc regulation of substrate metabolism is a reasonable target, as Myc alters metabolism in other tissues. We hypothesize that Myc-induced shifts in substrate utilization signal and promote compensated hypertrophy. We used cardiac specific Myc-inducible C57/BL6 male mice between 4-6 months old that develop hypertrophy with tamoxifen (tam). Isolated working hearts and 13Carbon (13C )-NMR were used to measure function and fractional contributions (Fc) to the citric acid cycle by using perfusate containing 13C-labeled free fatty acids,more » acetoacetate, lactate, unlabeled glucose and insulin. Studies were performed at pre-hypertrophy (3-days tam, 3dMyc), established hypertrophy (7-days tam, 7dMyc) or vehicle control (cont). Non-transgenic siblings (NTG) received 7-days tam or vehicle to assess drug effect. ...
https://www.osti.gov/pages/biblio/1229960-myc-alters-substrate-utilization-glcnac-protein-posttranslational-modifications-without-altering-cardiac-function-during-early-aortic-constriction
Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1...Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1...
Cardiac hypertrophy increases the risk of morbidity and mortality of cardiovascular disease and thus inhibiting such hypertrophy is beneficial. In the present study, we explored the effect of a bioactive peptide (PAP) on angiotensin II (Ang II)-induced hypertrophy and associated ventricular arrhythmias in in vitro and in vivo models. PAP enhances p21 activated kinase 1 (Pak1) activity by increasing the level of phosphorylated Pak1 in cultured neonatal rat ventricular myocytes (NRVMs). Such PAP-induced Pak1 activation is associated with a significant reduction of Ang II-induced hypertrophy in NRVMs and C57BL/6 mice, in vitro and in vivo, respectively. Furthermore, PAP antagonizes ventricular arrhythmias associated with Ang II-induced hypertrophy in mice. Its antiarrhythmic effect is likely to be involved in multiple mechanisms to affect both substrate and trigger of ventricular arrhythmogenesis. Thus our results suggest that Pak1 activation achieved by specific bioactive peptide represents a potential
https://www.cardioscience.ox.ac.uk/publications/475681
Growth Arrest-Specific 6 Exacerbates Pressure Overload-Induced Cardiac HypertrophyNovelty and Significance | HypertensionGrowth Arrest-Specific 6 Exacerbates Pressure Overload-Induced Cardiac HypertrophyNovelty and Significance | Hypertension
Pathological cardiac hypertrophy is a complicated dynamic process that ultimately leads to heart failure. At present, we still have few effective methods to reverse pathological cardiac hypertrophy. Because the cardiovascular mortality increased 6- to 10-fold because of the development of pathological cardiac hypertrophy,21 it is of great importance to elucidate the underlying molecular mechanism of cardiac hypertrophy and discover potential target molecules to regulate pathological cardiac hypertrophy. Using genetic loss-of-function and gain-of-function animal models, the present study provides the systemic direct evidence that selective inhibition of GAS6 may be a therapeutic target for treating cardiac hypertrophy and congestive heart failure.. Mechanical stress and neurohormone stimuli are the 2 major causes for pathological cardiac hypertrophy.22 Both of these initially cause number of extracellular molecules to bind with their receptors and subsequently activate intrinsic signaling ...
http://hyper.ahajournals.org/content/67/1/118
Abstract 18184: Deficiency in the Novel Small Leucin-Rich Repeat Protein Podocan Promotes Pressure Load-Induced Cardiac...Abstract 18184: Deficiency in the Novel Small Leucin-Rich Repeat Protein Podocan Promotes Pressure Load-Induced Cardiac...
Background: Extracellular matrix (ECM) molecules have been increasingly implicated in cardiac remodeling, and in particular the myocardial response to pressure overload. Podocan is a novel member of the small leucin-rich-repeat protein family of ECM proteins. We recently have characterized podocan as an inhibitor of the migration and proliferation of vascular smooth muscle cells. Now we are testing if podocan deficiency has an effect on pressure load-induced cardiac hypertrophy.. Methods and Results: We induced pressure overload cardiac hypertrophy using aortic banding (AB) in mice (age 10-12 weeks) with podocan-/- (n=6) and wild-type (WT) (n=7) genotype. Four weeks after AB, cardiac anatomy and function were assessed by echocardiography. In addition, histological analysis was used to assess the myocardial response to AB. Podocan-deficient mice showed significantly greater cardiac hypertrophy compared with WT mice after AB, whereas no significant differences were observed when comparing ...
http://circ.ahajournals.org/content/128/Suppl_22/A18184
Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy |...Neuron-derived orphan receptor-1 modulates cardiac gene expression and exacerbates angiotensin II-induced cardiac hypertrophy |...
Hypertensive cardiac hypertrophy (HCH) is a common cause of heart failure (HF), a major public health problem worldwide. However, the molecular bases of HCH have not been completely elucidated. Neuron-derived orphan receptor-1 (NOR-1) is a nuclear receptor whose role in cardiac remodelling is poorly understood. The aim of the present study was to generate a transgenic mouse over-expressing NOR-1 in the heart (TgNOR-1) and assess the impact of this gain-of-function on HCH. The CAG promoter-driven transgenesis led to viable animals that over-expressed NOR-1 in the heart, mainly in cardiomyocytes and also in cardiofibroblasts. Cardiomyocytes from TgNOR-1 exhibited an enhanced cell surface area and myosin heavy chain 7 (Myh7)/Myh6 expression ratio, and increased cell shortening elicited by electric field stimulation. TgNOR-1 cardiofibroblasts expressed higher levels of myofibroblast markers than wild-type (WT) cells (α 1 skeletal muscle actin (Acta1), transgelin (Sm22α)) and were more prone to ...
https://www.portlandpress.com/clinsci/article-abstract/134/3/359/221950/Neuron-derived-orphan-receptor-1-modulates-cardiac?redirectedFrom=fulltext
Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response<...Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response<...
TY - JOUR. T1 - Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response. AU - Van Berlo, Jop H.. AU - Aronow, Bruce J.. AU - Molkentin, Jeffery D.. PY - 2013/12/31. Y1 - 2013/12/31. N2 - The transcriptional code that programs cardiac hypertrophy involves the zinc finger-containing DNA binding factors GATA-4 and GATA-6, both of which are required to mount a hypertrophic response of the adult heart. Here we performed conditional gene deletion of Gata4 or Gata6 in the mouse heart in conjunction with reciprocal gene replacement using a transgene encoding either GATA-4 or GATA-6 in the heart as a means of parsing dosage effects of GATA-4 and GATA-6 versus unique functional roles. We determined that GATA-4 and GATA-6 play a redundant and dosage-sensitive role in programming the hypertrophic growth response of the heart following pressure overload stimulation. However, non-redundant functions were identified in allowing the heart to compensate and ...
https://experts.umn.edu/en/publications/parsing-the-roles-of-the-transcription-factors-gata-4-and-gata-6-
Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. ...Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. ...
Circulation. 2012 Oct 2;126(14):1705-16. doi: 10.1161/CIRCULATIONAHA.111.075978. Epub 2012 Aug 29. Research Support, N.I.H., Extramural
https://www.ncbi.nlm.nih.gov/pubmed/22932257?dopt=Abstract
Cardiomegaly - WikipediaCardiomegaly - Wikipedia
Cardiomegaly is a medical condition in which the heart is enlarged. It is more commonly referred to as an enlarged heart. The causes of cardiomegaly may vary. Many times this condition results from high blood pressure (hypertension) or coronary artery disease. An enlarged heart may not pump blood effectively, resulting in congestive heart failure. Cardiomegaly may improve over time, but many people with an enlarged heart need lifelong treatment with medications. Having an immediate family member who has or had cardiomegaly may indicate that a person is more susceptible to getting this condition. Cardiomegaly is not a disease but rather a condition that can result from a host of other diseases such as obesity or coronary artery disease. Recent studies suggest that cardiomegaly is associated with a higher risk of sudden cardiac death (SCD). Cardiomegaly is a condition affecting the cardiovascular system, specifically the heart. This condition is strongly associated with congestive heart failure. ...
https://en.wikipedia.org/wiki/Cardiomegaly
Cardiomegaly - WikipediaCardiomegaly - Wikipedia
The causes of cardiomegaly are not well understood and many cases of cardiomegaly are idiopathic (having no known cause). Prevention of cardiomegaly starts with detection. If a person has a family history of cardiomegaly, one should let ones doctor know so that treatments can be implemented to help prevent worsening of the condition. In addition, prevention includes avoiding certain lifestyle risk factors such as tobacco use and controlling ones high cholesterol, high blood pressure, and diabetes. Non-lifestyle risk factors include family history of cardiomegaly, coronary artery disease (CAD), congenital heart failure, Atherosclerotic disease, valvular heart disease, exposure to cardiac toxins, sleep disordered breathing (such as sleep apnea), sustained cardiac arrhythmias, abnormal electrocardiograms, and cardiomegaly on chest X-ray. Lifestyle factors which can help prevent cardiomegaly include eating a healthy diet, controlling blood pressure, exercise, medications, and not abusing alcohol ...
https://en.m.wikipedia.org/wiki/Enlarged_heart
Abstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload | CirculationAbstract 13685: Toll-Like Receptor 2 Mediates Cardiac Adaptive Response to Pressure Overload | Circulation
Background: Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. TLR2 is a member of the TLR family, and has been shown to recognize not only foreign substances, but also endogenous ligands, which induce inflammatory response called homeostatic inflammation. Recently, homeostatic inflammation has been revealed to contribute to the pathophysiology of various diseases. However, the role of homeostatic inflammation mediated by TLR2 on pressure overload-induced cardiac hypertrophy remains unclear.. Methods and Results: Pressure overload was induced in 8- to 12-week-old wild-type (WT) and TLR2 knock-out (KO) mice by transverse aortic constriction (TAC). In WT mice, TLR2 mRNA expression at 2 weeks after TAC was up-regulated compared with that after sham operation (1.32±0.18 versus 0.50±0.03, n=4, p=0.004). At 2 weeks after TAC, KO mice showed reduced cardiac hypertrophy and fibrosis with more left ventricular dilatation and impaired systolic function ...
http://circ.ahajournals.org/content/126/Suppl_21/A13685
cardiomegaly - Symptoms, Treatments and Resources for cardiomegalycardiomegaly - Symptoms, Treatments and Resources for cardiomegaly
cardiomegaly - MedHelps cardiomegaly Center for Information, Symptoms, Resources, Treatments and Tools for cardiomegaly. Find cardiomegaly information, treatments for cardiomegaly and cardiomegaly symptoms.
http://www.medhelp.org/tags/show/1502/cardiomegaly
Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling | Circulation...Genetic Manipulation of Periostin Expression Reveals a Role in Cardiac Hypertrophy and Ventricular Remodeling | Circulation...
Here we observed that Pn contributes to the cardiac hypertrophic response, an observation that was not anticipated, given its primary function as an ECM cellular adhesion protein. That a cellular adhesion protein might affect the cardiac hypertrophic response is not without precedence, especially given the known importance of integrins in regulating cardiac reactive signaling4,35 and given the known role of Pn as a substrate for multiple combinations of integrins. For example, both focal adhesion kinase and integrin-linked kinase, which are intracellular signaling components of the integrin complex, function as important regulators of the cardiac hypertrophy response.36,37 Indeed, mice lacking the protein osteopontin, which is another cardiac inducible and secreted ECM protein that binds integrins, showed less pressure overload hypertrophy compared with wild-type mice.38 Based on these results, it is tempting to speculate that Pn alters the cardiac hypertrophic response by affecting signaling ...
http://circres.ahajournals.org/content/101/3/313
Activation of Hypoxia-Inducible Factor-2 in Adipocytes Results in Pathological Cardiac Hypertrophy | Journal of the American...Activation of Hypoxia-Inducible Factor-2 in Adipocytes Results in Pathological Cardiac Hypertrophy | Journal of the American...
Our findings presented herein have uncovered a previously unappreciated transcription factor pathway, mediated by HIF-2 in adipocytes, that plays a critical role in the regulation of adipocyte functions. Chronic activation of HIF-2, but not HIF-1, in adipocytes leads to adipose inflammation and pathological hypertrophy in the heart. The hypertrophic heart conditions presented by our mouse models are reminiscent of the cardiac hypertrophy observed in severely obese persons.2 Our solid genetic evidence strongly suggests that adipose hypoxia, observed under the condition of pathological obesity,5-7 may facilitate the development of obesity-related cardiac hypertrophy via sustained activation of HIF-2 in adipocytes.. Our findings demonstrate that HIF activation in adipocytes exerts its cardiac effects in a manner distinct from other purported mechanisms linked to obesity-associated cardiomyopathy. The pathological cardiomegaly observed herein occurs in the absence of lipid accumulation in blood ...
http://jaha.ahajournals.org/content/2/6/e000548
Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy - pdf descargarSpeckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy - pdf descargar
Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun9/149853919176-Speckle-Tracking-Based-Strain-Analysis-Is-Sensitive-for-Early-Detection-of-Pathological-Cardiac-Hypertrophy.php
Regulation of fetal gene expression in heart failure<...Regulation of fetal gene expression in heart failure<...
TY - JOUR. T1 - Regulation of fetal gene expression in heart failure. AU - Dirkx, Ellen. AU - da Costa Martins, Paula A.. AU - De Windt, Leon J.. PY - 2013/12. Y1 - 2013/12. KW - Gene regulation. KW - Transcription factors. KW - Epigenetics. U2 - 10.1016/j.bbadis.2013.07.023. DO - 10.1016/j.bbadis.2013.07.023. M3 - Article. VL - 1832. SP - 2414. EP - 2424. JO - Biochimica et Biophysica Acta-Molecular Basis of Disease. JF - Biochimica et Biophysica Acta-Molecular Basis of Disease. SN - 0925-4439. IS - 12. ER - ...
https://cris.maastrichtuniversity.nl/en/publications/regulation-of-fetal-gene-expression-in-heart-failure
Plus itPlus it
Physiological cardiac growth occurs during postnatal development, and in response to long-term exercise training (15). This form of hypertrophy is associated with normal or enhanced cardiac function and normal cardiac structure. In contrast, pathological cardiac hypertrophy may arise as a compensatory mechanism against increased myocyte stress in many disease states. Any initial benefit is however overridden by eventual derangement of myocardial architecture and deterioration of function (15). Diabetic cardiomyopathy is characterized by adverse structural changes to the heart, including increased cardiac fibrosis (pathological in nature) and cardiomyocyte hypertrophy. Our results show that diabetes increased several markers of cardiomyocyte hypertrophy, including cardiomyocyte width as well as gene expression of β-myosin heavy chain, ANP, and BNP as previously described (13). No changes in heart weight-to-body weight or heart weight-to-tibia length ratios were observed in Ntg diabetic mice, ...
http://diabetes.diabetesjournals.org/content/59/6/1512
glossary:cardiomegaly [Lymphedema People]glossary:cardiomegaly [Lymphedema People]
An abnormal enlargement of the heart; mild cardiomegaly is common in athletes. Cardiomegaly is a condition wherein the heart enlarges in a cardiothoracic ratio of more than 0.50. It can be attributed to a lot of causes, but mostly it is because of low heart output, otherwise referred to as a cardiac failure. A cardiothoracic ratio is the way to measure the size of a persons heart. In this case, cardiomegaly occurs if the heart is more than 50 percent bigger than the inner diameter of ones rib cage. Cardiomegaly is assumed to be the direct effect of the thickening of the heart muscles and that happens when the heart is given an increased workload. This increase workload on the other hand, may be due to other health conditions present in the body. Viral illnesses and previous heart attacks can cause the heart to overwork. Drug abuse, inflammation of the heart, and uncontrolled hypertension are the known issues that may give rise to cardiomegaly. ...
http://lymphedemapeople.com/wiki/doku.php?id=glossary:cardiomegaly
glossary:cardiomegalyglossary:cardiomegaly
An abnormal enlargement of the heart; mild cardiomegaly is common in athletes. Cardiomegaly is a condition wherein the heart enlarges in a cardiothoracic ratio of more than 0.50. It can be attributed to a lot of causes, but mostly it is because of low heart output, otherwise referred to as a cardiac failure. A cardiothoracic ratio is the way to measure the size of a persons heart. In this case, cardiomegaly occurs if the heart is more than 50 percent bigger than the inner diameter of ones rib cage. Cardiomegaly is assumed to be the direct effect of the thickening of the heart muscles and that happens when the heart is given an increased workload. This increase workload on the other hand, may be due to other health conditions present in the body. Viral illnesses and previous heart attacks can cause the heart to overwork. Drug abuse, inflammation of the heart, and uncontrolled hypertension are the known issues that may give rise to cardiomegaly. ...
http://www.lymphedemapeople.com/wiki/doku.php?id=glossary:cardiomegaly
Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats |...Cardiac hypertrophy is stimulated by altered training intensity and correlates with autophagy modulation in male Wistar rats |...
The mechanism for cardiac hypertrophy process that would be a benefit for improvement of cardiovascular endurance needed to be investigated throughly. Specific intensity of training may play a role for homeostasis process in cardiac during training. In the present study, we examine the effect of different intensity of treadmill training on cardiac hypertrophy process and autophagy related gene expression in male wistar rats. Three different intensities of treadmill training were conducted on 15 male wistar rats (Low Intensity: 10 m/minute, Moderate Intensity: 20 m/minute, and High Intensity: 30 m/minute) compared to 5 sedentary rats as control. Training duration was 30 min per day, frequency was 5 days per week, during 8 weeks period. Heart weight and heart weight/body weight ratio were measured after the experiments. Left ventricle myocardium was taken for microscopic analysis with HE staining. mRNA was extracted from left ventricle myocardium for examining αMHC and autophagy related gene expression
https://bmcsportsscimedrehabil.biomedcentral.com/articles/10.1186/s13102-019-0121-0/email/correspondent/c1/new
Estrogen receptor-β mediates male-female differences in the development of pressure overload hypertrophy | Heart and...Estrogen receptor-β mediates male-female differences in the development of pressure overload hypertrophy | Heart and...
We found that hypertrophy induced secondary to pressure overload was significantly less in female WT mice compared with age-matched male WT mice at 2 wk postsurgery. We were therefore interested in determining whether this male/female difference was mediated via the ER and, if so, which receptor.. Direct effects of estrogen on the myocardium have been demonstrated (7, 14, 26), but the physiological roles of ER-α and ER-β in the myocardium remain largely unexplored. For the first time, we report the response of ERKO mice to pressure overload hypertrophy. We found that homozygous α-ERKO female mice exhibit a response to TAC that is identical to the response of WT females. This finding indicates that ER-α is not essential for the attenuation of the hypertrophic response. In contrast, we found that homozygous β-ERKO female mice subjected to TAC exhibited an increased degree of hypertrophy compared with WT female mice, comparable to WT males, indicating a role for ER-β in mediating an ...
http://ajpheart.physiology.org/content/288/2/H469.long
Phenotyping Hypertrophy | Circulation ResearchPhenotyping Hypertrophy | Circulation Research
The widespread use of the term hypertrophy to describe one or a few specific pathophysiological conditions is a holdover from the earliest scientific work on cardiac response to stress, in which cardiac enlargement was largely assumed to be the result of increased cardiomyocyte size and was qualitatively predictable based on the nature of the provocative stimulus.4 Hence, morphogenic changes in the heart were classified by the nature of the inciting hemodynamic stress as pressure-overload or volume-overload hypertrophy, referring to concentric hypertrophy (increased thickness of ventricular walls with little or no change in chamber volume) and eccentric hypertrophy (increased chamber volume with ventricular wall thickness increased in proportion with chamber dimensions), respectively. Note that, in both forms of hypertrophy, cardiac dry mass is increased. These etiologic/morphometric descriptors could be further categorized as compensated or decompensated, based on left ventricular ...
http://circres.ahajournals.org/content/92/11/1171
日本超音波医学会会員専用サイト日本超音波医学会会員専用サイト
阿部 美保1, 福田 信夫2, 井形 次郎1, 稲山 久美1, 福田 保1, 篠原 尚典2, 添木 武2, 酒部 宏一2, 小野瀬 由紀子2, 田村 禎通2. Miho ABE1, Nobuo FUKUDA2, Ziro IKATA1, Kumi INAYAMA1, Tamotsu FUKUDA1, Hisanori SHINOHARA2, Takeshi SOEKI2, Kouichi SAKABE2, Yukiko ONOSE2, Yoshiyuki TAMURA2. 1公立学校共済組合四国中央病院内科, 2国立善通寺病院循環器科・臨床研究部. 1Depertment of Internal Medicine Shikoku Central Hospital, 2Division of Cardiology, and Clinical Research, Zentsuji National Hospital. キーワード : acute myocarditis, diastolic dysfunction of the ventricle, echocardiography, mitral annular velocity, left ventricular inflow velocity A man aged 27 years was admitted to the hospital because of fever and general fatigue. The electrocardiogram showed abnormal Q wave in leads II, III, and aVF, and poor R-wave progression in leads V3 through V6 at time of admission. The chest roentgenogram showed cardiac enlargement and no ...
https://www.jsum.or.jp/journals/2474
Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice.Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice.
Serotonin, in addition to its fundamental role as a neurotransmitter, plays a critical role in the cardiovascular system, where it is thought to be involved in the development of cardiac hypertrophy and failure. Indeed, we recently found that mice with deletion of monoamine oxidase A had enhanced levels of blood and cardiac 5-HT, which contributed to exacerbation of hypertrophy in a model of experimental pressure overload. 5-HT2A receptors are expressed in the heart and mediate a hypertrophic response to 5-HT in cardiac cells. However, their role in cardiac remodeling in vivo and the signaling pathways associated are not well understood. In the present study, we evaluated the effect of a selective 5-HT2A receptor antagonist, M100907, on the development of cardiac hypertrophy induced by transverse aortic constriction (TAC). Cardiac 5-HT2A receptor expression was transiently increased after TAC, and was recapitulated in cardiomyocytes, as observed with 5-HT2A in situ labeling by immunohistochemistry.
http://www.hal.inserm.fr/inserm-00852242
Support the Hypertrophic Heart Center | Tufts Medical CenterSupport the Hypertrophic Heart Center | Tufts Medical Center
Support the Hypertrophic Heart Center at Tufts Medical Center in Boston by making a donation to help improve patient care, research, and clinical trials.
https://www.tuftsmedicalcenter.org/patient-care-services/Departments-and-Services/Hypertrophic-Cardiomyopathy-Center/Support-HCM-Center
Difference Between Cardiomegaly and Cardiomyopathy | Cardiomegaly vs CardiomyopathyDifference Between Cardiomegaly and Cardiomyopathy | Cardiomegaly vs Cardiomyopathy
What is the difference between Cardiomegaly and Cardiomyopathy? Cardiomegaly, the abnormal enlargement of heart, is a clinical manifestation of cardiomyopathies
http://www.differencebetween.com/difference-between-cardiomegaly-and-vs-cardiomyopathy/
Weight Loss Workout Without CardiomegalyWeight Loss Workout Without Cardiomegaly
An enlarged heart, or cardiomegaly, is a symptom of another medical condition it is not a. Physicians at the Mayo Clinic advise that patients with cardiomegaly get modest exercise, after. How to Reduce Estrogen in Men Through the Diet. Adherence to an appropriate diet and regular exercise. Diet should. Cardiomegaly. A nine pound weight loss was re-. vascular markings, and normal exercise tol erance without stridor. The patient. ale due to airway obstruction but without.
http://pacifichealthedu.info/weight-loss-workout-without-cardiomegaly_rc.htm
Biochemistry of Hypertrophy and Heart Failure by Danny P. Goel, David A. Ford (auth.), Lorrie A. Kirshenbaum, - LibraryBiochemistry of Hypertrophy and Heart Failure by Danny P. Goel, David A. Ford (auth.), Lorrie A. Kirshenbaum, - Library
Yet not much is known about patients with PA, VSD at a cellular level, so any available new data for this group is taken along in the understanding of this disease. As mentioned earlier, we studied limited numbers of patients and controls. Therefore the conclusions can only be drawn with caution. It may be added here that the limited clinical data on normal myocardium in young healthy children is a limitation of our study as well. We are currently accumulating appropriate tissue biopsies to increase the number of contro ls. Two of these mutations are found within a troponin T binding site, located at amino acids 175 and 180. In this study, we analyze a transgenic mouse model for one of the mutations that occur at codon 180: a substitution of a glutami c acid for a glycine. These mice develop severe cardiac hypertrophy, substantial interstitial fibrosis, and have an increased heart weight! body weight ratio . Results show that calcium-handling proteins associated with the sarcoplasmic reticulum ...
http://mamenchica.com/index.php/download/biochemistry-of-hypertrophy-and-heart-failure
JCI - The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophyJCI - The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated these marks with their associated transcriptomes. This analysis revealed the pervasive loss of euchromatic H3K9me2 as a conserved feature of pathological hypertrophy that was associated with reexpression of fetal genes. In hypertrophy, H3K9me2 was reduced following a miR-217-mediated decrease in expression of the H3K9 dimethyltransferases EHMT1 and EHMT2 (EHMT1/2). miR-217-mediated, genetic, ...
https://www.jci.org/articles/view/88353/pdf
Top Cardiomegaly Hospitals in Bangalore | CredihealthTop Cardiomegaly Hospitals in Bangalore | Credihealth
View details of top cardiomegaly hospitals in Bangalore. Get guidance from medical experts to select best cardiomegaly hospital in Bangalore
https://www.credihealth.com/hospitals/bangalore/cardiomegaly
Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload...Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload...
Tolerance of the canine heart to prolonged ischemic arrest was studied in 10 hearts from normal control dogs and 15 hearts from dogs with left ventricular hypertrophy (LVH); experiments were performed 1 year after banding the aorta in 8-week-old pupp
http://www.biomedsearch.com/nih/Tolerance-hypertrophic-heart-to-ischemia/2139593.html
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function | PNASPTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function | PNAS
We present several noteworthy observations from our genetic deletion studies supporting the importance of PINK1 in the murine heart during postnatal development. In particular, PINK1−/− mice develop LV dysfunction with a reduced fractional shortening and evidence of pathological cardiac hypertrophy as early as 2 mo of age. Associated with this baseline cardiac phenotype we have shown that the PINK1−/− mice have higher degrees of cardiomyocyte apoptosis with fibrosis and reciprocal reduction in capillary density. In addition, the PINK1−/− mice have greater levels of oxidative stress as reflected by higher levels of lipid peroxidation, DNA damage, and decreased aconitase activity in conjunction with reduced activity of several cytoplasmic and mitochondrial antioxidative systems. In response to biomechanical stress, the PINK1−/− mice developed a further exaggeration in the degree of cardiac hypertrophy compared with their littermate controls. Of clinical relevance is the finding ...
https://www.pnas.org/content/108/23/9572?ijkey=c75d6d6ee87f87916243fa7f11b1f334c25118da&keytype2=tf_ipsecsha
Application Of Gene Expression Data And Cellular Automata To Predict Disease Progress In A Cardiac Hypertrophy ModelApplication Of Gene Expression Data And Cellular Automata To Predict Disease Progress In A Cardiac Hypertrophy Model
The discernment of gene expression changes at the molecular level presents great opportunities to conquer human disease; therefore it is important that...
https://www.witpress.com/elibrary/dne-volumes/6/1/499
Hypertensive Heart Disease | The Virtual Physiological Rat ProjectHypertensive Heart Disease | The Virtual Physiological Rat Project
Hypertension can lead to hypertrophic heart disease is a multi-factorial, multi-scale problem in which altered whole body hemodynamics and neurohormonal factors lead to a complex growth and remodeling response in the heart. The cells and extracellular matrix in the myocardium initially compensate to the abnormal environmental factors with altered gene expression, changes in contractile and mechanoenergetic function, cell and tissue structural remodeling, in turn further affecting circulatory dynamics and often leading to decompensation and failure. The goal of this project is to integrate novel cell signaling models of myocyte hypertrophy into organ-level continuum models of ventricular growth, remodeling and mechanoenergetics coupled to hemodynamic models of systemic hypertension, and validate these multi-scale models with experiments in rats subjected to ventricular hemodynamic overload and treated with drugs that target key response pathways. The resulting model systems will enable ...
http://vpr.sites.uofmhosting.net/research-projects/hypertensive-heart-disease
Sex- and oestrogen-dependent regulation of miRNAs in cardiac hypertrophySex- and oestrogen-dependent regulation of miRNAs in cardiac hypertrophy
The present study aimed to identify sex-differently expressed miRNAs in a late stage of hypertrophy (9 weeks) and the possible role of ERs in the regulation of these differences. Our previous studies identified ERbeta as an important determinant factor of the observed sex differences in pressure overload, playing different roles in males and females. This report identified a total of 30 miRNAs with sex and/or sex*surgery interaction effect 9 weeks after TAC in WT mice. The same effects were not observed in ERbeta-/- animals partially due to the higher expression of these miRNAs in ERbeta-/- females than in their WT counterparts. This study reveals a repression of a number of miRNAs by estradiol and its receptors alpha and beta in female cardiomyocytes, confirming the in vivo results and accentuating the important protective role of oestrogen and ERbeta in the female heart. Six of the miRNAs with sex differences in WT but not in ERbeta-/- hypertrophy models were found to be possible fibrosis ...
https://edoc.hu-berlin.de/handle/18452/17817
NO TABOO: The treatmentNO TABOO: The treatment
They asked themselves, how can something as commonplace and benign as a fruit extract reverse so many aspects of coronary artery disease, simultaneously, as it was evidenced by the study above? They say that the answer might be found in the fact that our ancestors evolved together with certain foods (fruits in particular) for so long that a lack of adequate quantities of these foods may directly result in deteriorating organ function. The journal Atherosclerosis published an interesting study in which they confirm that pomegranate extract may reverse or/and prevent the primary pathology associated with cardiac mortality: the accumulation of fatty materials on the coronary arteries known as atherosclerosis.What really surprised the researchers,were the other beneficial effects of the pomegranate extract treatment: Reduced lipid accumulation in the heart muscle Reduced ECG abnormalities Reduced levels of oxidative stress Reduced cardiac enlargement Reduced monocytie chemotactic protein-1, a ...
http://notaboohere.blogspot.com/2017/04/the-treatment.html
The effects of FABP4 on cardiac hypertrophy ended up investigated in the presence of an ERK signaling inhibitor PD098059 | www...The effects of FABP4 on cardiac hypertrophy ended up investigated in the presence of an ERK signaling inhibitor PD098059 | www...
Notably, the Ang II-induced expression of hypertrophic hall marks had been also profoundly enhanced in Advertisement-FABP4-infected NRCMs compared with
http://www.nrtisinhibitor.com/2016/06/21/the-effects-of-fabp4-on-cardiac-hypertrophy-ended-up-investigated-in-the-presence-of-an-erk-signaling-inhibitor-pd098059/
Enlarged Heart (Cardiomegaly): Causes, Treatment, and More- dr-china.infoEnlarged Heart (Cardiomegaly): Causes, Treatment, and More- dr-china.info
Cardiomegaly, or an enlarged heart, can be caused by a birth defect or it can develop later in life. Treatment and outlook depend on the underlying cause.
http://dr-china.info/health/enlarged-heart
Cardiomegaly | Causes, Symptoms & Treatment | MercyCardiomegaly | Causes, Symptoms & Treatment | Mercy
Cardiomegaly, which is an enlargement of the heart, may develop from a number of conditions. Learn more about the causes, symptoms & treatment.
https://www.mercy.net/service/cardiomegaly/
Glycogen disease; report of two cases with cardiomegaly.<...Glycogen disease; report of two cases with cardiomegaly.<...
TY - JOUR. T1 - Glycogen disease; report of two cases with cardiomegaly.. AU - MARTIN, J. F.. AU - BONTE, F. J.. PY - 1951/12/1. Y1 - 1951/12/1. UR - http://www.scopus.com/inward/record.url?scp=0041689496&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0041689496&partnerID=8YFLogxK. M3 - Article. C2 - 14894746. AN - SCOPUS:0041689496. VL - 66. SP - 922. EP - 928. JO - American Journal of Roentgenology. JF - American Journal of Roentgenology. SN - 0361-803X. IS - 6. ER - ...
https://utsouthwestern.pure.elsevier.com/en/publications/glycogen-disease-report-of-two-cases-with-cardiomegaly
About Cardiomegaly | allnursesAbout Cardiomegaly | allnurses
About Cardiomegaly - Welcome to my allnursesPage! You can learn all about me here. Together, we can learn, share, and network with nurses and nursing students from all around the world.
http://allnurses.com/member-715440/
Sodium Ferulate Protects against Angiotensin II-Induced Cardiac Hypertrophy in Mice by Regulating the MAPK/ERK and JNK PathwaysSodium Ferulate Protects against Angiotensin II-Induced Cardiac Hypertrophy in Mice by Regulating the MAPK/ERK and JNK Pathways
|i|Background and Objective|/i|. It has been reported that sodium ferulate (SF) has hematopoietic function against anemia and immune regulation, inflammatory reaction inhibition, inhibition of tumor cell proliferation, cardiovascular and cerebrovascular protection, and other functions. Thus, this study aimed to investigate the effects of SF on angiotensin II- (AngII-) induced cardiac hypertrophy in mice through the MAPK/ERK and JNK signaling pathways.|i| Methods|/i|. Seventy-two male C57BL/6J mice were selected and divided into 6 groups: control group, PBS group, model group (AngII), model + low-dose SF group (AngII + 10 mg/kg SF), model + high-dose SF group (AngII + 40 mg/kg SF), and model + high-dose SF + agonist group (AngII + 40 mg/kg SCU + 10 mg/kg TBHQ). After 7 d/14 d/28 days of treatments, the changes of blood pressure and heart rates of mice were compared. The morphology of myocardial tissue and the apoptosis rate of myocardial cells were observed. The mRNA and protein expressions of atrial
https://www.hindawi.com/journals/bmri/2017/3754942/
Left atrial enlargement: Causes, signs and symptoms, and treatment - Latin-HeartsLeft atrial enlargement: Causes, signs and symptoms, and treatment - Latin-Hearts
Detecting left atrial enlargement is frequently suspected in line with the presentation of signs and symptoms of the underlying cardiogenic condition. Once other tests addressing other complications are carried out to assist eliminate any potentially existence-threatening disorders, additional testing searching in the structure from the heart can be achieved to find out if left atrial enlargement exists.. Probably the most generally done test to identify left atrial enlargement is applying imaging methods known as echocardiograms. To control your emotions by utilizing seem waves to consider images of the center structures. Using other imaging tests, namely CT or MRI scans, may also be used to identify left atrial enlargement.. With respect to the underlying condition, treatment will normally follow. For instance, treating high bloodstream pressure calls for the effective use of bloodstream pressure medication for example beta-blockers and diuretics. Also, maintaining a healthy diet plan, ...
http://latin-hearts.com/left-atrial-enlargement-causes-signs-and-symptoms-and-treatment/
Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome. | Nat Commun...Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome. | Nat Commun...
Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-activating RAF1 alleles typically develop pathological left ventricular hypertrophy (LVH), which is reproduced in Raf1L613V/+ knock-in mice. Here, using inducible Raf1L613V expression, we show that LVH results from the interplay of cardiac cell types. Cardiomyocyte Raf1L613V enhances Ca2+ sensitivity and cardiac contractility without causing hypertrophy. Raf1L613V expression in cardiomyocytes or activated fibroblasts exacerbates pressure overload-evoked fibrosis. Endothelial/endocardial (EC) Raf1L613V causes cardiac hypertrophy without affecting contractility. Co-culture and neutralizing antibody experiments reveal a cytokine (TNF/IL6) hierarchy in Raf1L613V-expressing ECs that drives cardiomyocyte hypertrophy in vitro. Furthermore, postnatal TNF inhibition normalizes the increased wall thickness and cardiomyocyte hypertrophy ...
https://pesquisa.bvsalud.org/portal/resource/pt/mdl-28548091
Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload (Journal Article) ...Taxifolin protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload (Journal Article) ...
Cardiac hypertrophy is a key pathophysiological component to biomechanical stress, which has been considered to be an independent and predictive risk factor for adverse cardiovascular events. Taxifolin (TAX) is a typical plant flavonoid, which has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. However, very little is known about whether TAX can influence the development of cardiac hypertrophy. In vitro studies, we found that TAX concentration-dependently inhibited angiotensin II (Ang II) induced hypertrophy and protein synthesis in cardiac myocytes. Then we established a mouse model by transverse aortic constriction (TAC) to further confirm our findings. It was demonstrated that TAX prevented pressure overload induced cardiac hypertrophy in mice, as assessed by ventricular mass/body weight, echocardiographic parameters, myocyte cross-sectional area, and the expression of ANP, BNP and β-MHC. The excess production of reactive oxygen species (ROS) played ...
https://www.osti.gov/scitech/biblio/22465817-taxifolin-protects-against-cardiac-hypertrophy-fibrosis-during-biomechanical-stress-pressure-overload
Frontiers | Toll-Like Receptor 4 Inhibition Improves Oxidative Stress and Mitochondrial Health in Isoproterenol-Induced Cardiac...Frontiers | Toll-Like Receptor 4 Inhibition Improves Oxidative Stress and Mitochondrial Health in Isoproterenol-Induced Cardiac...
Background- Inflammation remains a crucial factor for progression of cardiac diseases and cardiac hypertrophy remains an important cause of cardiac failure over all age groups. As a key regulator of inflammation, toll like receptor 4 (TLR4) plays an important role in pathogenesis of cardiac diseases. Being an important regulator of innate immunity, the precise pathway of TLR4 mediated cardiac complications is yet to be established. Therefore, the primary objective of the present study was to find the role of TLR4 in cardiac hypertrophy and the molecular mechanism thereof. Methods- Cardiac hypertrophy was induced with administration of isoproterenol (5mg/kg/day, sc). TLR4 receptor inhibitor RS-LPS (lipopolysaccharide from the photosynthetic bacterium Rhodobacter sphaeroides; 5 microgram/day) and agonist LPS (Lipopolysaccharide from Escherichia coli; 3.12 microgram/day) were administered through osmotic pump along with isoproterenol. Cardiac hypertrophy as well as oxidative stress and mitochondrial
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00719/full
Effect of SKF‑96365 on cardiomyocyte hypertrophy induced by angiotensin IIEffect of SKF‑96365 on cardiomyocyte hypertrophy induced by angiotensin II
Angiotensin II (Ang II) is an important bioactive peptide in the renin‑angiotensin system, and it can contribute to cell proliferation and cardiac hypertrophy. Dysfunctions in transient receptor potential canonical (TRPC) channels are involved in many types of cardiovascular diseases. The aim of the present study was to investigate the role of the TRPC channel inhibitor SKF‑96365 in cardiomyocyte hypertrophy induced by Ang II and the potential mechanisms of SKF‑96365. H9c2 cells were treated with different concentrations of Ang II. The expression levels of cardiomyocyte hypertrophy markers and TRPC channel‑related proteins were also determined. The morphology and surface area of the H9c2 cells, the expression of hypertrophic markers and TRPC channel‑related proteins and the [3H] leucine incorporation rate were detected in the Ang II‑treated H9c2 cells following treatment with the TRPC channel inhibitor SKF‑96365. The intracellular Ca2+ concentration was tested by flow cytometry. ...
https://tessera.spandidos-publications.com/10.3892/mmr.2019.10877/abstract
Collaborative Regulation of LRG1 by TGF-beta 1 and PPAR-beta/delta Modulates Chronic Pressure Overload-Induced Cardiac FibrosisCollaborative Regulation of LRG1 by TGF-beta 1 and PPAR-beta/delta Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis
BACKGROUND:Despite its established significance in fibrotic cardiac remodeling, clinical benefits of global inhibition of TGF (transforming growth factor)-β1 signaling remain controversial. LRG1 (leucine-rich-α2 glycoprotein 1) is known to regulate endothelial TGFβ signaling. This study evaluated the role of LRG1 in cardiac fibrosis and its transcriptional regulatory network in cardiac fibroblasts. METHODS:Pressure overload-induced heart failure was established by transverse aortic constriction. Western blot, quantitative reverse transcription polymerase chain reaction, immunofluorescence, and immunohistochemistry were used to evaluate the expression level and pattern of interested targets or pathology during fibrotic cardiac remodeling. Cardiac function was assessed by pressure-volume loop analysis. RESULTS:LRG1 expression was significantly suppressed in left ventricle of mice with transverse aortic constriction-induced fibrotic cardiac remodeling (mean difference, -0.00085 [95% CI, -0.0013 ...
https://scholars.latrobe.edu.au/display/publication834819
Pituitary Adenylate Cyclase Activating Peptide Receptors | Selective Sirt2 inhibition by ligand-induced rearrangementPituitary Adenylate Cyclase Activating Peptide Receptors | Selective Sirt2 inhibition by ligand-induced rearrangement
Supplementary MaterialsSupplementary Information 41598_2019_44331_MOESM1_ESM. in CACNA1H the denseness of DHPR and RyR2 clusters with pressure-overload cardiac hypertrophy and a rise in the denseness of SERCA2A proteins clusters. PLN proteins clusters reduced in denseness in 2-week TAC but came back to sham amounts Meptyldinocap by 4-week TAC. Furthermore, 2D-FFT evaluation revealed adjustments in molecular firm during pathological hypertrophy, with RyR2 and DHPR becoming dispersed while both SERCA2A and PLN sequestered into dense clusters. Our function reveals molecular adaptations that happen in important SR protein at an individual molecule during pressure overload-induced cardiomyopathy. Nanoscale modifications in proteins localization and patterns of manifestation of important SR proteins inside the cardiomyocyte offered insights in to the pathogenesis of cardiac hypertrophy, and particular proof that cardiomyocytes go through significant structural redesigning during the development of ...
http://themodernsolution.com/category/pituitary-adenylate-cyclase-activating-peptide-receptors/
Mitoquinone Ameliorates Pressure Overload-Induced Cardiac Fibrosis and by Kah Yong Goh, Li He et al.Mitoquinone Ameliorates Pressure Overload-Induced Cardiac Fibrosis and by Kah Yong Goh, Li He et al.
Increasing evidence indicates that mitochondrial-associated redox signaling contributes to the pathophysiology of heart failure (HF). The mitochondrial-targeted antioxidant, mitoquinone (MitoQ), is capable of modifying mitochondrial signaling and has shown beneficial effects on HF-dependent mitochondrial dysfunction. However, the potential therapeutic impact of MitoQ-based mitochondrial therapies for HF in response to pressure overload is reliant upon demonstration of improved cardiac contractile function and suppression of deleterious cardiac remodeling. Using a new (patho)physiologically relevant model of pressure overload-induced HF we tested the hypothesis that MitoQ is capable of ameliorating cardiac contractile dysfunction and suppressing fibrosis. To test this C57BL/6J mice were subjected to left ventricular (LV) pressure overload by ascending aortic constriction (AAC) followed by MitoQ treatment (2 µmol) for 7 consecutive days. Doppler echocardiography showed that AAC caused severe LV
https://scholarcommons.usf.edu/intmed_facpub/15/
The Effect of 12-Week Resistance Training on Cardiac Hypertrophy Glucose Level Insulin and Insulin Resistance Index in STZ...The Effect of 12-Week Resistance Training on Cardiac Hypertrophy Glucose Level Insulin and Insulin Resistance Index in STZ...
Background and Objectives: Type 2 diabetes is a risk factor for heart disease and has a major contribution in mortality due to cardiovascular diseases. In the present study, the effect of 12-week resistance training was investigated on cardiac hypertrophy, glucose, level, insulin, and insulin resistance index in STZ-induced diabetic rats. Methods: A total of ...
http://journal.muq.ac.ir/article-1-436-en.html
381 Does the BNP may be used as a biochemical marker for assessing severity of left ventricular hypertrophy in aortic stenosis?381 Does the BNP may be used as a biochemical marker for assessing severity of left ventricular hypertrophy in aortic stenosis?
54 Downregulation Erb2 and Erb4 receptors in patients with congestive cardiomyopathy and in patients with pressure overload hypertrophy due to aortic stenosis is related to diastolic load. Delrue, L.; Bartunek, J.; Goethals, M.; De Bruyne, B.; De Beenhouwer, H.; Vanderheyden, M. // European Journal of Heart Failure. Supplements;Jun2004, Vol. 3 Issue 1, p12 An abstract of the study Downregulation Erb2 and Erb4 Receptors in Patients With Congestive Cardiomyopathy and in Patients With Pressure Overload Hypertrophy Due to Aortic Stenosis Is Related to Diastolic Load, by L. Delrue and colleagues is presented. ...
http://connection.ebscohost.com/c/abstracts/14270528/381-does-bnp-may-be-used-as-biochemical-marker-assessing-severity-left-ventricular-hypertrophy-aortic-stenosis
Aging | Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy - FigureAging | Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy - Figure
Circular RNA (circRNA) is a novel class of noncoding RNAs, and the roles of circRNAs in the development of cardiac hypertrophy remain to be explored. Here, we investigate the potential roles of circRNAs in cardiac hypertrophy. By circRNA sequencing in left ventricular specimens collected from 8-week-old mice with isoproterenol hydrochloride-induced cardiac hypertrophy, we found 401 out of 3323 total circRNAs were dysregulated in the hypertrophic hearts compared with the controls. Of these, 303 circRNAs were upregulated and 98 were downregulated. Moreover, the GO and KEGG analyses revealed that the majority of parental gene of differentially expressed circRNAs were not only related to biological process such as metabolic process and response to stimulus, but also related to pathway such as circulatory system and cardiovascular diseases. On the other hand, total 1974 miRNAs were predicted to binding to these differentially expressed circRNAs, and the possible target mRNAs of those miRNAs were also
https://www.aging-us.com/figure/102761/f10
ECG: left atrial enlargement | DiagnosaurusECG: left atrial enlargement | Diagnosaurus
ECG: left atrial enlargement answers are found in the Diagnosaurus powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://im.unboundmedicine.com/medicine/view/Diagnosaurus/114633/all/ECG:_left_atrial_enlargement
JCI - Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of...JCI - Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of...
The heart initially compensates for hypertension-mediated pressure overload by enhancing its contractile force and developing hypertrophy without dilation. Gq protein-coupled receptor pathways become activated and can depress function, leading to cardiac failure. Initial adaptation mechanisms to reduce cardiac damage during such stimulation remain largely unknown. Here we have shown that this initial adaptation requires regulator of G protein signaling 2 (RGS2). Mice lacking RGS2 had a normal basal cardiac phenotype, yet responded rapidly to pressure overload, with increased myocardial Gq signaling, marked cardiac hypertrophy and failure, and early mortality. Swimming exercise, which is not accompanied by Gq activation, induced a normal cardiac response, while Rgs2 deletion in Gαq-overexpressing hearts exacerbated hypertrophy and dilation. In vascular smooth muscle, RGS2 is activated by cGMP-dependent protein kinase (PKG), suppressing Gq-stimulated vascular contraction. In normal mice, but not ...
https://www.jci.org/articles/view/35620/pdf
Myocardial and Coronary Effects of Propofol in Rabbits with Compensated Cardiac Hypertrophy | Anesthesiology | ASA PublicationsMyocardial and Coronary Effects of Propofol in Rabbits with Compensated Cardiac Hypertrophy | Anesthesiology | ASA Publications
In the current study, we used an experimental model of compensated cardiac hypertrophy induced by pressure overload over a 12-week period. The degree of hypertrophy induced in our study (136 ± 21%) was consistent with previous studies using the same model and reported a mean cardiac hypertrophy of 127%11 and 136%. 32 These authors reported noncardiac abnormalities associated with cardiac hypertrophy, including skeletal and diaphragmatic muscle abnormalities, without any physical signs of congestive heart failure, but they did not perform accurate evaluation of myocardial performance. 11 Our results showed a preserved state of contractility as indicated by the absence of significant difference in indexed Emaxbetween SHAM and LVH groups but an alteration of the diastolic compliance in the LVH group (fig. 1). These results explain significant differences in the inotropic and lusitropic baseline values between SHAM and LVH1groups. In the latter group, by altered diastolic compliance, the value of ...
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1944520
Role of cyclin-dependent Kinase 9 in the zebrafish embryonic heartRole of cyclin-dependent Kinase 9 in the zebrafish embryonic heart
Cardiac hypertrophy leading to heart failure remains a leading cause of morbidity and mortality in the 21st century despite major therapeutic advances. Improved understanding of novel molecular and cellular processes contributing to cardiac hypertrophy therefore continues to be important. Cyclin-dependent Kinase 9 (CDK9), part of a family of proteins controlling cell cycle and growth, has emerged as one such potential candidate over the last 5 years. CDK9 is the catalytic subunit of the CDK9/CyclinT complex and acts by phosphorylating the carboxy-terminal domain of RNA polymerase II. Hypertrophic signals, such as Endothelin-1 (ET-1) and phenylephrine, have been shown to cause CDK9 activation leading to a hypertrophic response in cultured mouse cardiomyocytes associated with reactivation of the foetal gene program. CDK9 also forms a complex with GATA4 to play a role in differentiation of mouse ES cells into cardiomyocytes. These findings suggest a specific role for CDK9 in controlling growth and ...
https://www.era.lib.ed.ac.uk/handle/1842/11820
IP3 Receptor Linked to Cardiac Hypertrophy - Drug Discovery OpinionIP3 Receptor Linked to Cardiac Hypertrophy - Drug Discovery Opinion
Cardiac hypertrophy is a thickening of the heart muscle - characterized by increased cell size rather than number - in response to conditions such as high blood pressure and coronary heart disease, which results in a decrease in size of the chambers of the heart, including the left and right ventricles. Since hypertrophy is associated with heart failure, irregular heart rhythms and an increased risk of angina and heart attack, understanding the mechanisms underlying this abnormal thickening is of great importance. Scientists at the Babraham Institute have now identified a new signalling process in the heart which contributes to cardiac hypertrophy. Rhythmical Ca2+ increases are fundamental to contraction of the heart muscle, but elevated Ca2+ levels also regulate the gene transcription that leads to hypertrophy. The Babraham team found that it is localised increases in Ca2+ concentrations in the cell nucleus that activate the genes responsible for hypertrophy. These nuclear Ca2+ signals, which ...
http://drugdiscoveryopinion.com/2009/03/ip3-receptor-linked-to-cardiac-hypertrophy/
ACROMEGALY AND THE HEART: A CLINICAL AND PATHOLOGIC STUDY* | Annals of Internal Medicine | American College of PhysiciansACROMEGALY AND THE HEART: A CLINICAL AND PATHOLOGIC STUDY* | Annals of Internal Medicine | American College of Physicians
Heart disease has long been known as a frequent complicating factor and a common cause of exitus in acromegaly. Only nine years after the recognition of the features of acromegaly by Marie1 in 1886, Huchard2 reported cardiac enlargement in the clinical and autopsy findings of three patients with the disease. Fournier3 drew particular attention to the features of cardiac failure in a series of 25 patients, pointing out the frequent association of cardiomegaly with hypertrophy of all the viscera. Similar reports, consisting usually of one or two cases, have appeared from time to time in the French and German literature, ...
http://annals.org/aim/article-abstract/674692/acromegaly-heart-clinical-pathologic-study
Plus itPlus it
Four weeks of aortic banding resulted in significant hypertrophy in rats. This was evident from a significant increase in LVm/BW ratios. Furthermore, the hypertrophy was concentric in nature as evident from significant increases in the IVS and LVPW, an indication of increased septal and posterior wall thickness, respectively, at both systole and diastole. There was no change observed in LVID, an indication of increased chamber size, at systole and diastole. Results of the current study are consistent with results from our previous study (4). Treatment of aortic-banded rats with 2.5 mg·kg−1·day−1 resveratrol completely prevented development of hypertrophy because there was a normalization of the increase in left ventricle-to-body weight ratio. Resveratrol treatment also prevented concentric remodeling by normalizing IVS and LVPW at both systole and diastole. The beneficial effects of resveratrol in preventing PO-induced cardiac hypertrophy are consistent with another recent study, which ...
http://ajpheart.physiology.org/content/292/5/H2138
cNMA and Fuzzy -Logic Based Ligand Screening for Preventing Myocardial Lipid Accumulation in Pressure-Overload Cardiac...cNMA and Fuzzy -Logic Based Ligand Screening for Preventing Myocardial Lipid Accumulation in Pressure-Overload Cardiac...
Inherited and acquired cardiomyopathy due to obesity and diabetes results in impaired lipid accumulation in the myocyte. Lipid accumulation in the heart leads t
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3529895
left ventricular hypertrophy - Heartbeats of Licking Countyleft ventricular hypertrophy - Heartbeats of Licking County
September 29th is World Heart Day, that is held and arranged through the world heart foundation. The objective of this occasion would be to inform people about cardiovascular illnesses, which cause most cases of avoidable dying on the planet. To higher facilitate this purpose, weve compiled a summary of articles to assist enable you to get began on what causes cardiovascular disease. Youll find info on what can cause an enlarged heart and fluid round the heart, diabetes and cardiovascular disease, and what to anticipate throughout a massive cardiac arrest. Hopefully these details might help our readers and potentially save a existence later on.. Cardiomegaly (enlarged heart) isnt an illness by itself, but instead an indicator of some other condition. An enlarged heart is visible on X-ray images, but additional exams are needed to look for the exact reason for cardiomegaly.. Cardiomegaly could be temporary or chronic, based on its underlying cause. Oftentimes, cardiomegaly is really a ...
http://heartbeats-olc.org/tag/left-ventricular-hypertrophy/
A change of heart: Epigenetic basis of cardiac hypertrophy uncoveredA change of heart: Epigenetic basis of cardiac hypertrophy uncovered
Their research, published in the Journal of Clinical Investigation, compared the differences between hypertrophic heart growth in rats as a result of exercise - which is beneficial - and heart growth induced by pathology - in this case increased load. Specifically, they compared epigenetic marks responsible for locking cells in their final developed state - important for preventing cells from switching to a less differentiated state. Notably for their analysis, the researchers employed a powerful cell sorting technique to allow them to study pure populations of heart muscle cells (cardiomyocytes) rather than a mix of all cell types in the heart - which, due to an alteration in composition during disease, would confound analysis ...
http://www.vib.be/en/news/Pages/A-change-of-heart.aspx
ESC calls for renaming of term cardiac hypertrophy | Cardiovascular NewsESC calls for renaming of term cardiac hypertrophy | Cardiovascular News
The term myocardial hypertrophy, say the working group, lacks precision. In cell biology the term hypertrophy describes growth via cell enlargement as opposed to growth by cell division, where hyperplasia is the correct term. Currently in cardiology the term hypertrophy is commonly applied to the situation in the whole heart where myocardial enlargement is accompanied by both hypertrophy and hyperplasia. In addition the term hypertrophy does not take account of the fact that non myocytes in the heart are not passive bystanders and also change in number when the heart remodels. Additionally there may be an invasion of inflammatory cells into the heart, and angiogenesis may occur.. The advantage of the term cardiac remodelling is that it simply defines reorganisation of the different cardiac tissue components, and can be used to describe an increase, or decrease in the size of the left ventricle, as well as a change to the cellular components, explained the first author of the paper, Ralph ...
https://cardiovascularnews.com/esc-calls-for-renaming-of-term-cardiac-hypertrophy/
Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice.Apocynin attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction in mice.
To investigate whether apocynin, a NADPH oxidase inhibitor, produced cardioproteictive effects in Ang II-induced hypertensive mice, and to elucidate the underlying mechanisms. C57BL/6 mice were subcutaneously infused Ang II for 4 weeks to mimic
http://www.biomedsearch.com/nih/Apocynin-attenuates-oxidative-stress-cardiac/23334241.html
Most recent papers with the keyword Transverse aortic constriction | Read by QxMDMost recent papers with the keyword Transverse aortic constriction | Read by QxMD
Dipeptidyl peptidase-4 (DPP-4) inhibitors are hypoglycemic agents. DPP-4 inhibitor has cardioprotective effects after transverse aortic constriction (TAC), but role of DPP-4 on cardiac fibrosis after TAC is not well known. Our aim was to determine the effects of DPP-4 on cardiac fibrosis in murine TAC model. Wild-type mice and DPP-4 knockout mice were subjected to TAC. Wild-type mice were then treated with vehicle or DPP-4 inhibitor. DPP-4 activities in serum and heart tissue were significantly increased at 2 weeks after TAC, but they were significantly decreased by DPP-4 inhibitor treatment ...
https://www.readbyqxmd.com/keyword/53493
Signs or symptoms hematomacrosis - Tips and Tricks From DoctorsSigns or symptoms hematomacrosis - Tips and Tricks From Doctors
Signs or symptoms hematomacrosis - What are the symptoms of hemochromatosis? Varies. Many times, it is only presented with high iron saturation and or iron storage without having any symptoms. However, the clinical manifestations of iron accumulation can include liver disease, elevation of liver enzymes, skin pigmentation, diabetes mellitus, arthropathy, impotence in males, and cardiac enlargement with or without heart failure or conduction defects etc.
https://www.healthtap.com/topics/signs-or-symptoms-hematomacrosis
Plus itPlus it
Although cardiac hypertrophy is an important condition that usually precedes heart failure (Carreno et al., 2006), there are limited reports of altered expression of P450 genes during cardiac hypertrophy. The expression of P450 has been studied in SHRs as compared with SD rats (Thum and Borlak, 2002) and the expression of sEH has been studied in spontaneously hypertensive heart failure (SHHF) rats as compared with normal strains (Monti et al., 2008). Nevertheless, there are no data about the effect of experimentally induced cardiac hypertrophy on the expression of P450 and sEH genes and their associated P450-derived metabolites of AA. To the best of our knowledge, this work demonstrates for the first time the effect of experimentally induced cardiac hypertrophy on the expression of several P450 genes and P450-dependent AA metabolism in rats. In addition, the current study demonstrates the tissue-specific expression of many P450 genes and sEH in male SD rats.. Tissue-specific expression of P450 ...
http://dmd.aspetjournals.org/content/36/11/2277
Therapeutic inhibition of the miR-34 family (miR-34a -b -c) or miR-34a - BRAF inhibitors on Immune-based antitumor therapyTherapeutic inhibition of the miR-34 family (miR-34a -b -c) or miR-34a - BRAF inhibitors on Immune-based antitumor therapy
Therapeutic inhibition of the miR-34 family (miR-34a -b -c) or miR-34a only have emerged as encouraging strategies for the treating cardiac pathology. safety this approach will probably result in much less potential off-target results. Subsequently silencing of miR-34a only may be inadequate in configurations of founded cardiac pathology. We lately proven Cobicistat that inhibition from the miR-34 family members however not miR-34a only provided benefit inside a chronic style of myocardial infarction. Inhibition of miR-34 also attenuated cardiac redesigning and improved center function pursuing pressure overload nevertheless silencing of miR-34a only was not analyzed. The purpose of this research was to assess whether inhibition of miR-34a could attenuate cardiac redesigning inside a mouse model with pre-existing pathological hypertrophy. Mice had been put through pressure overload via constriction from the transverse aorta for a month and echocardiography was performed to verify remaining ...
http://www.bioinbrief.com/2017/05/29/therapeutic-inhibition-of-the-mir-34-family-mir-34a-b-c-or-mir-34a/
Left atrial enlargement increases the risk of major adverse cardiac events independent of coronary vasodilator capacity. |...Left atrial enlargement increases the risk of major adverse cardiac events independent of coronary vasodilator capacity. |...
Sigma-Aldrich offers abstracts and full-text articles by [Angela S Koh, Venkatesh L Murthy, Arkadiusz Sitek, Peter Gayed, John Bruyere, Justina Wu, Marcelo F Di Carli, Sharmila Dorbala].
https://www.sigmaaldrich.com/catalog/papers/26012901
Enlarged Aortic Root Left Atrial Enlargement Sigmoid Septum - Coronary ArteryEnlarged Aortic Root Left Atrial Enlargement Sigmoid Septum - Coronary Artery
Figure 2-35 Various locations of left ventricular false tendons. A. Two false tendons arrows from posteromedial mitral papillary muscle PM to ventricular
https://www.78stepshealth.us/coronary-artery/b.html
Riaz HaiderRiaz Haider
A rare cause of cardiomegaly". British Heart Journal. 35 (9): 981-984. doi:10.1136/hrt.35.9.981. ISSN 0007-0769. PMC 458738. ...
https://en.wikipedia.org/wiki/Riaz_Haider
MegacolonMegacolon
Koeberle F (1963). "Enteromegaly and cardiomegaly in Chagas disease". Gut. 4 (4): 399-405. doi:10.1136/gut.4.4.399. PMC 1413478 ...
https://en.wikipedia.org/wiki/Megacolon
Left ventricular hypertrophyLeft ventricular hypertrophy
Cardiomegaly Ventricular hypertrophy Primary hyperparathyroidism Maron, Barry J; Maron, Martin S (2013-01-19). "Hypertrophic ...
https://en.wikipedia.org/wiki/Left_ventricular_hypertrophy
Ernest BethellErnest Bethell
He died of cardiomegaly on 1 May 1909. The Korean people erected a monument in his honour. This was defaced by the Japanese. ...
https://en.wikipedia.org/wiki/Ernest_Bethell
Fritz KöberleFritz Köberle
Koeberle, F. Enteromegaly and cardiomegaly in Chagas disease. Gut. 1963 Dec;41:399-405. Rezende, J.M.: Fritz Köberle and his ... cardiomegaly, heart ventricular aneurysm, achalasia, etc., and the mechanism of the causation of these several pathologies. By ...
https://en.wikipedia.org/wiki/Fritz_Köberle
Rh factor testingRh factor testing
Splenomegaly, cardiomegaly and hepatomegaly may occur in the baby. Excessive tissue fluid may accumulate in the stomach, lungs ...
https://en.wikipedia.org/wiki/Rh_factor_testing
Emmanuel Badu KobiEmmanuel Badu Kobi
The actor was reported suffering from enlargement of the heart or cardiomegaly. In February 2019, Abronye DC of the ruling New ...
https://en.wikipedia.org/wiki/Emmanuel_Badu_Kobi
Right atrial enlargementRight atrial enlargement
... (RAE) is a form of cardiomegaly, or heart enlargement. It can broadly be classified as either right ...
https://en.wikipedia.org/wiki/Right_atrial_enlargement
Max BarrettMax Barrett
Barrett, A. M. (1963). "Arterial measurements in the interpretation of cardiomegaly at necropsy: Cardiac hypertrophy and ...
https://en.wikipedia.org/wiki/Max_Barrett
David Alexander (singer)David Alexander (singer)
In November 1994, Alexander was rushed into hospital and diagnosed with cardiomegaly (an enlarged heart). He was advised by ...
https://en.wikipedia.org/wiki/David_Alexander_(singer)
Seth RobertsSeth Roberts
Occlusive coronary artery disease and cardiomegaly contributed to his death. Seth Roberts Blog. "Seth", 27 April 2014. ...
https://en.wikipedia.org/wiki/Seth_Roberts
Athletic heart syndromeAthletic heart syndrome
Cardiomegaly is the state of an enlarged heart, and cardiac hypertrophy the thickening of the muscular wall of the heart, ... Athlete's heart is not dangerous for athletes (though if a nonathlete has symptoms of bradycardia, cardiomegaly, and cardiac ... cardiomegaly, and cardiac hypertrophy. Bradycardia is a slower than normal heartbeat, at around 40-60 beats per minute. ...
https://en.wikipedia.org/wiki/Athletic_heart_syndrome
Left atrial enlargementLeft atrial enlargement
... and is a form of cardiomegaly. Left atrial enlargement can be mild, moderate or severe depending on the extent of the ...
https://en.wikipedia.org/wiki/Left_atrial_enlargement
Apex beatApex beat
... called cardiomegaly. The apex beat may also be displaced by other conditions: Pleural or pulmonary diseases Deformities of the ...
https://en.wikipedia.org/wiki/Apex_beat
Glycogen storage disease type IIGlycogen storage disease type II
The usual presenting features are cardiomegaly (92%), hypotonia (88%), cardiomyopathy (88%), respiratory distress (78%), muscle ... due to cardiomegaly), arrhythmias and evidence of heart failure. Prior to the development of a treatment, median age at death ...
https://en.wikipedia.org/wiki/Glycogen_storage_disease_type_II
Systemic primary carnitine deficiencySystemic primary carnitine deficiency
... cardiomegaly, cardiomyopathy and marked carnitine deficiency in plasma and tissues, combined with increased excretion in urine ...
https://en.wikipedia.org/wiki/Systemic_primary_carnitine_deficiency
List of MeSH codes (C23)List of MeSH codes (C23)
... cardiomegaly MeSH C23.300.775.525 - hepatomegaly MeSH C23.300.775.750 - splenomegaly MeSH C23.300.825.411 - intestinal polyps ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C23)
Singleton Merten syndromeSingleton Merten syndrome
... cardiomegaly, and intramural calcification of the proximal aorta with occasional extension into the aortic or mitral valves.[ ...
https://en.wikipedia.org/wiki/Singleton_Merten_syndrome
Cardiovascular diseaseCardiovascular disease
Inflammatory cardiomegaly Myocarditis - inflammation of the myocardium, the muscular part of the heart, caused most often by ...
https://en.wikipedia.org/wiki/Cardiovascular_disease
AnagrelideAnagrelide
Less common side effects include: congestive heart failure, myocardial infarction, cardiomyopathy, cardiomegaly, complete heart ...
https://en.wikipedia.org/wiki/Anagrelide
Hypertensive heart diseaseHypertensive heart disease
An enlarged heart (cardiomegaly). *Left ventricular hypertrophy and left ventricular remodeling[5] ...
https://en.wikipedia.org/wiki/Hypertensive_heart_disease
HeartHeart
"Comparing fist size to heart size is not a viable technique to assess cardiomegaly". Cardiovascular Pathology: The Official ...
https://en.wikipedia.org/wiki/Heart
Don HoDon Ho
By 2002, he had developed cardiomegaly, an enlarged heart, unrelated to coronary artery disease, leaving him with only 30% of ...
https://en.wikipedia.org/wiki/Don_Ho
Wernicke encephalopathyWernicke encephalopathy
... and also patients may have developed cardiomegaly.[26] Heart failure with lactic acidosis syndrome has been observed.[27] ...
https://en.m.wikipedia.org/wiki/Wernicke's_encephalopathy
TachycardiaTachycardia
The word tachycardia came to English from New Latin as a neoclassical compound built from the combining forms tachy- + -cardia, which are from the Greek ταχύς tachys, "quick, rapid" and καρδία, kardia, "heart". As a matter both of usage choices in the medical literature and of idiom in natural language, the words tachycardia and tachyarrhythmia are usually used interchangeably, or loosely enough that precise differentiation is not explicit. Some careful writers have tried to maintain a logical differentiation between them, which is reflected in major medical dictionaries[7][8][9] and major general dictionaries.[10][11][12] The distinction is that tachycardia be reserved for the rapid heart rate itself, regardless of cause, physiologic or pathologic (that is, from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form (that is, an arrhythmia of the rapid rate type). This is why five of the previously referenced ...
https://en.wikipedia.org/wiki/Reflex_tachycardia
Atrial fibrillationAtrial fibrillation
Anticoagulation can be used to reduce the risk of stroke from AF. Anticoagulation is recommended in most people other than those at low risk of stroke[77] or those at high risk of bleeding. The risk of falls and consequent bleeding in frail elderly people should not be considered a barrier to initiating or continuing anticoagulation since the risk of fall-related brain bleeding is low and the benefit of stroke prevention often outweighs the risk of bleeding.[78][79] Similarly, the presence or absence of AF symptoms does not determine whether a person warrants anticoagulation and is not an indicator of stroke risk.[33] Oral anticoagulation is underused in atrial fibrillation, while aspirin is overused in many who should be treated with a direct oral anticoagulant (DOAC) or warfarin.[80][81][82] In 2019, DOACs were often recommended over warfarin by the American Heart Association.[83] The risk of stroke from non-valvular AF can be estimated using the CHA2DS2-VASc score. In the 2019 AHA/ACC/HRS ...
https://en.wikipedia.org/wiki/Atrial_fibrillation
Lown-Ganong-Levine syndromeLown-Ganong-Levine syndrome
LGL syndrome is diagnosed in a person who has experienced episodes of abnormal heart racing (arrhythmias) who has a PR interval less than or equal to 0.12 second (120 ms) with normal QRS complex configuration and duration on their resting ECG.[1] A short PR interval found incidentally on an ECG without episodes of tachycardia is simply a benign ECG variant. LGL can be distinguished from WPW syndrome because the delta waves seen in WPW syndrome are not seen in LGL syndrome. The QRS complex will also be narrow in LGL syndrome, as opposed to WPW, because ventricular conduction is via the His-Purkinje system. Lown-Ganong-Levine syndrome is a clinical diagnosis that came about before the advent of electrophysiology studies. It is important to be aware that not all WPW ECGs have a delta wave; the absence of a delta wave does not conclusively rule out WPW. ...
https://en.wikipedia.org/wiki/Lown–Ganong–Levine_syndrome
Premature junctional contractionPremature junctional contraction
... s (PJCs), also called atrioventricular junctional premature complexes or junctional extrasystole, are premature cardiac electrical impulses originating from the atrioventricular node of the heart or "junction". This area is not the normal but only a secondary source of cardiac electrical impulse formation. These premature beats can be found occasionally in healthy people and more commonly in some pathologic conditions, typically in the case of drug cardiotoxicity, electrolyte imbalance, mitral valve surgery, and cold water immersion.[1] If more than two such beats are seen, then the condition is termed junctional rhythm. On the surface ECG, premature junctional contractions will appear as a normally shaped ventricular complex or QRS complex, not preceded by any atrial complex or P wave or preceded by an abnormal P wave with a shorter PR interval. Rarely, the abnormal P wave can follow the QRS.[2] ...
https://en.wikipedia.org/wiki/Premature_junctional_contractions
BigeminyBigeminy
After any PVC there is a pause that can lead to the development of bigeminy. A PVC wavefront often encounters a refractory AV node that does not conduct the wavefront retrograde. Thus the atrium is not depolarized and the sinus node is not reset. Since the sinus p wave to PVC interval is less than the normal P-P interval, the interval between the PVC and the next p wave is prolonged to equal the normal time elapsed during two P-P intervals. This is called a "compensatory" pause. The pause after the PVC leads to a longer recovery time, which is associated with a higher likelihood of myocardium being in different stages of repolarization. This then allows for re-entrant circuits and sets up the ventricle for another PVC after the next sinus beat.[2] The constant interval between the sinus beat and PVC suggests a reentrant etiology rather than spontaneous automaticity of the ventricle.[3] Atrial premature complexes (APCs) do not have a compensatory pause since they reset the sinus node but atrial ...
https://en.wikipedia.org/wiki/Ventricular_bigeminy
ICD-10 Chapter IX: Diseases of the circulatory systemICD-10 Chapter IX: Diseases of the circulatory system
I51.7) Cardiomegaly *Ventricular hypertrophy *Left ventricular hypertrophy. *(I51.8) Other ill-defined heart diseases ...
https://en.wikipedia.org/wiki/ICD-10_Chapter_IX:_Diseases_of_the_circulatory_system
AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
CardiomegalyHydrops FetalisCardiomegaly, Exercise-InducedJamaicaRadiography, ThoracicCardiomyopathiesArteriovenous FistulaPericardial EffusionChagas CardiomyopathyFetal DiseasesUltrasonography, PrenatalHeart NeoplasmsHeart FailureFatal OutcomeElectrocardiographyEchocardiographyHeart Defects, CongenitalMyocardiumPregnancyRetrospective StudiesInfant, NewbornHypertensionPrognosisStudentsNursesEncyclopedias as TopicRisk FactorsMedical Missions, OfficialNaval MedicineFractures, CompressionVertebroplastyPleural EffusionPulmonary AtelectasisSpinal Cord CompressionAnemiaPercussionPulmonary Disease, Chronic ObstructiveDyspneaInternal MedicineThoracic Surgical ProceduresDyspnea, ParoxysmalAngina PectorisLymphedemaVirus DiseasesWorkloadHeartTerminology as TopicCopyrightDictionaries, MedicalDictionaries as TopicNigeriaDictionaries, ChemicalDiagnostic and Statistical Manual of Mental Disorders
About Cardiomegaly | allnursesAbout Cardiomegaly | allnurses
About Cardiomegaly - Welcome to my allnursesPage! You can learn all about me here. Together, we can learn, share, and network ...
http://allnurses.com/member-715440/
Cardiomegaly - WikipediaCardiomegaly - Wikipedia
"What Is an Enlarged Heart (Cardiomegaly)?". WebMD.. *^ a b c d e f g h i "Enlarged heart - Symptoms and causes". mayoclinic.org ... The causes of cardiomegaly are not well understood and many cases of cardiomegaly are idiopathic (having no known cause). ... There are two main types of cardiomegaly: Dilated cardiomyopathy is the most common type of cardiomegaly. In this condition, ... Prevention of cardiomegaly starts with detection. If a person has a family history of cardiomegaly, one should let ones doctor ...
https://en.m.wikipedia.org/wiki/Enlarged_heart
cardiomegaly - Symptoms, Treatments and Resources for cardiomegalycardiomegaly - Symptoms, Treatments and Resources for cardiomegaly
Treatments and Tools for cardiomegaly. Find cardiomegaly information, treatments for cardiomegaly and cardiomegaly symptoms. ... cardiomegaly - MedHelps cardiomegaly Center for Information, Symptoms, Resources, ... what do mean by mild cardiomegaly? This discussion is related to Mild Cardiomegaly. ... ... can a radiologist see moderate cardiomegaly from a chest and abdomen ct scan w(with and w/o... ...
http://www.medhelp.org/tags/show/1502/cardiomegaly
Cardiomegaly | Causes, Symptoms & Treatment | MercyCardiomegaly | Causes, Symptoms & Treatment | Mercy
Cardiomegaly, which is an enlargement of the heart, may develop from a number of conditions. Learn more about the causes, ... The term cardiomegaly most commonly refers to an enlarged heart. It is not a disease, but rather a symptom of another disease ... How is Cardiomegaly Treated?. Treatments for an enlarged heart focus on correcting the cause. Based on the problem, your doctor ...
https://www.mercy.net/service/cardiomegaly/
glossary:cardiomegaly [Lymphedema People]glossary:cardiomegaly [Lymphedema People]
glossary:cardiomegaly. An abnormal enlargement of the heart; "mild cardiomegaly is common in athletes". Cardiomegaly is a ... Cardiomegaly is assumed to be the direct effect of the thickening of the heart muscles and that happens when the heart is given ... In this case, cardiomegaly occurs if the heart is more than 50 percent bigger than the inner diameter of ones rib cage. ... Drug abuse, inflammation of the heart, and uncontrolled hypertension are the known issues that may give rise to cardiomegaly. ...
http://lymphedemapeople.com/wiki/doku.php?id=glossary:cardiomegaly
Weight Loss Workout Without CardiomegalyWeight Loss Workout Without Cardiomegaly
Cardiomegaly. A nine pound weight loss was re-. vascular markings, and normal exercise tol erance without stridor. The patient ... Physicians at the Mayo Clinic advise that patients with cardiomegaly get modest exercise, after. How to Reduce Estrogen in Men ... or cardiomegaly, is a symptom of another medical condition it is not a. ... Weight Loss Workout Without Cardiomegaly. Indians came to the celebration in automobiles, deep pits were dug, 2008, the lawless ...
http://pacifichealthedu.info/weight-loss-workout-without-cardiomegaly_rc.htm
Top Cardiomegaly Hospitals in Bangalore | CredihealthTop Cardiomegaly Hospitals in Bangalore | Credihealth
Get guidance from medical experts to select best cardiomegaly hospital in Bangalore ... View details of top cardiomegaly hospitals in Bangalore. ... Best hospitals for cardiomegaly in Bangalore List of best ... Need help in choosing the right cardiomegaly hospital? The medical expert will guide you for all hospital needs ... Need help in choosing the right cardiomegaly hospital? The medical expert will guide you for all hospital needs ...
https://www.credihealth.com/hospitals/bangalore/cardiomegaly
Difference Between Cardiomegaly and Cardiomyopathy | Cardiomegaly vs CardiomyopathyDifference Between Cardiomegaly and Cardiomyopathy | Cardiomegaly vs Cardiomyopathy
Cardiomegaly, the abnormal enlargement of heart, is a clinical manifestation of cardiomyopathies ... What is the difference between Cardiomegaly and Cardiomyopathy? ... Cardiomegaly vs Cardiomyopathy. An abnormal enlargement of the ... Cardiomegaly Causes, Cardiomegaly Clinical features, Cardiomegaly Definition, Cardiomegaly Diagnosis, Cardiomegaly Management, ... Filed Under: Cardiology Tagged With: Cardiomegaly, Cardiomegaly and Cardiomyopathy Differences, Cardiomegaly and Cardiomyopathy ...
http://www.differencebetween.com/difference-between-cardiomegaly-and-vs-cardiomyopathy/
Enlarged Heart (Cardiomegaly): Causes, Treatment, and More- dr-china.infoEnlarged Heart (Cardiomegaly): Causes, Treatment, and More- dr-china.info
Cardiomegaly, or an enlarged heart, can be caused by a birth defect or it can develop later in life. Treatment and outlook ... What Is Mild Cardiomegaly?. Mild cardiomegaly can be a sign of a heart condition. Learn more about the symptoms and treatment ... An enlarged heart (cardiomegaly) means that your heart is bigger than normal. Your heart can become enlarged if the muscle ... Congenital cardiomegaly is a heart disorder youre born with. Congenital heart defects that cause this symptom include:. *. ...
http://dr-china.info/health/enlarged-heart
Glycogen disease; report of two cases with cardiomegaly.<...Glycogen disease; report of two cases with cardiomegaly.<...
MARTIN, J. F. ; BONTE, F. J. / Glycogen disease; report of two cases with cardiomegaly. In: The American journal of ... MARTIN, J. F., & BONTE, F. J. (1951). Glycogen disease; report of two cases with cardiomegaly. The American journal of ... MARTIN, JF & BONTE, FJ 1951, Glycogen disease; report of two cases with cardiomegaly., The American journal of roentgenology ... Glycogen disease; report of two cases with cardiomegaly. The American journal of roentgenology, radium therapy, and nuclear ...
https://utsouthwestern.pure.elsevier.com/en/publications/glycogen-disease-report-of-two-cases-with-cardiomegaly
Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload...Tolerance of the hypertrophic heart to ischemia. Studies in compensated and failing dog hearts with pressure overload...
Cardiomegaly / physiopathology*. Coronary Circulation / physiology*. Dogs. Heart Arrest, Induced*. Heart Ventricles / ...
http://www.biomedsearch.com/nih/Tolerance-hypertrophic-heart-to-ischemia/2139593.html
Cardiomegaly and Cardiomyopathy | HealthCentralCardiomegaly and Cardiomyopathy | HealthCentral
https://www.healthcentral.com/encyclopedia/cardiomegaly-and-cardiomyopathy. Encyclopedia /C /. Cardiomegaly and Cardiomyopathy ...
https://healthcentral.com/encyclopedia/cardiomegaly-and-cardiomyopathy
Cardiomegaly and Cardiomyopathy | HealthCentralCardiomegaly and Cardiomyopathy | HealthCentral
Description There are three basic types of cardiomyopathy: 1. Dilated cardiomyopathy. The heart muscle becomes weak and the heart chambers subsequently enlarge (dilate). 2. Hypertrophic cardiomyopathy
https://www.healthcentral.com/encyclopedia/cardiomegaly-and-cardiomyopathy
Enlarged Heart (Cardiomegaly): Causes, Treatment, and MoreEnlarged Heart (Cardiomegaly): Causes, Treatment, and More
Cardiomegaly, or an enlarged heart, can be caused by a birth defect or it can develop later in life. Treatment and outlook ... An enlarged heart (cardiomegaly) means that your heart is bigger than normal. Your heart can become enlarged if the muscle ... Congenital cardiomegaly is a heart disorder youre born with. Congenital heart defects that cause this symptom include:. * ... Mild cardiomegaly can be a sign of a heart condition. Learn more about the symptoms and treatment options. ...
https://www.healthline.com/health/enlarged-heart
Enlarged heart (cardiomegaly): Causes, symptoms, diagnosis and treatmentEnlarged heart (cardiomegaly): Causes, symptoms, diagnosis and treatment
Cardiomegaly (enlarged heart) isnt a disease on its own, but rather a symptom of another condition. An enlarged heart can be ... Cardiomegaly can be temporary or chronic, depending on its underlying cause. In many cases, cardiomegaly is a treatable ... Cardiomegaly (enlarged heart) isnt a disease on its own, but rather a symptom of another condition. An enlarged heart can be ... seen on X-ray images, but additional tests are required to determine the exact cause of cardiomegaly. ...
https://www.selfgrowth.com/articles/httpswwwbelmarrahealthcomenlarged-heart-cardiomegaly-causes-symptoms-diagnosis-treatment
Splenomegaly, Cardiomegaly, and Osteoporosis in a Child with Gaucher DiseaseSplenomegaly, Cardiomegaly, and Osteoporosis in a Child with Gaucher Disease
At the age of 4 years, severe osteoporosis and cardiomegaly with pulmonary congestion were observed in the child. Molecular ... Splenomegaly, Cardiomegaly, and Osteoporosis in a Child with Gaucher Disease. J. J. Sheth,1 C. M. Ankleshwaria. ,1 M. A. Mistri ... Splenomegaly, Cardiomegaly, and Osteoporosis in a Child with Gaucher Disease,. Case Reports in Pediatrics,. vol. 2011. ,. ... Cardiomegaly with pulmonary congestion was also observed at this time, and it is likely to occur due to frank infiltration of ...
https://www.hindawi.com/journals/cripe/2011/564868/
What Are the Treatments for Cardiomegaly? | Livestrong.comWhat Are the Treatments for Cardiomegaly? | Livestrong.com
Cardiomegaly occurs from multiple causes, and poorly controlled high blood pressure is a common factor. ... Cardiomegaly is an enlarged heart and a symptom of cardiomyopathy, or disease of the heart. ... Cardiomegaly is an enlarged heart and a symptom of cardiomyopathy, or disease of the heart. Cardiomegaly occurs from multiple ... Cardiomegaly weakens the heart muscle and reduces the ability of the heart to pump blood to the rest of the body. Treatment for ...
https://www.livestrong.com/article/185678-what-are-the-treatments-for-cardiomegaly/
A 76-year-old woman with anaemia and cardiomegaly | HeartA 76-year-old woman with anaemia and cardiomegaly | Heart
Because her chest radiography showed cardiomegaly and left-sided pleural effusion with small atelectasis, transthoracic ...
http://heart.bmj.com/content/103/24/2009
Precordial percussion for detecting cardiomegaly | Annals of Internal Medicine | American College of PhysiciansPrecordial percussion for detecting cardiomegaly | Annals of Internal Medicine | American College of Physicians
Precordial percussion for detecting cardiomegaly. ACP J Club. 1992;116:20. doi: 10.7326/ACPJC-1992-116-1-020 ... To assess the accuracy of precordial percussion and apical impulse palpation in detecting cardiomegaly radiographically. ... Accuracy of precordial percussion in detecting cardiomegaly. Am J Med. 1991 Oct;91:328-34. ...
http://annals.org/aim/article-abstract/2535111/precordial-percussion-detecting-cardiomegaly
GM1-generalized gangliosidosis variant with cardiomegaly | Postgraduate Medical JournalGM1-generalized gangliosidosis variant with cardiomegaly | Postgraduate Medical Journal
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
https://pmj.bmj.com/content/52/605/159.info
cardiomegaly | Tabers Medical Dictionarycardiomegaly | Taber's Medical Dictionary
cardiomegaly answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, ... cardiomegaly is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please sign in or purchase a ... "Cardiomegaly." Tabers Medical Dictionary, 23rd ed., F.A. Davis Company, 2017. Tabers Online, www.tabers.com/tabersonline/view ... Dictionary/731709/all/cardiomegaly. Cardiomegaly. In: Venes D, ed. Tabers Medical Dictionary. 23rd ed. F.A. Davis Company; ...
https://www.tabers.com/tabersonline/view/Tabers-Dictionary/731709/all/cardiomegaly
Zoloft Cardiomegaly Side EffectsZoloft Cardiomegaly Side Effects
View Cardiomegaly Zoloft side effect risks. Male, weighting 17.00 lb, was diagnosed with depression and took Zoloft 25 Mg Daily ... Is Cardiomegaly a common side effect of Zoloft? ... Cardiomegaly This Cardiomegaly Zoloft side effect was reported ... Zoloft Cardiomegaly Side Effect Reports. Home → Zoloft → Cardiomegaly The following Zoloft Cardiomegaly side effect reports ... Atrial Septal Defect, Cardiomegaly This Cardiomegaly Zoloft side effect was reported by a consumer or non-health professional ...
http://patientsville.com/zoloft/cardiomegaly.htm
Giant left atrium: a forgotten cause of cardiomegaly | Postgraduate Medical JournalGiant left atrium: a forgotten cause of cardiomegaly | Postgraduate Medical Journal
References (1)Shah BN., Rubens M Giant left atrium: a forgotten cause of cardiomegaly Postgrad Med J 2012;88:673-4 (2) Puri A ... References (1)Shah BN., Rubens M Giant left atrium: a forgotten cause of cardiomegaly Postgrad Med J 2... ... Vijay SK., Chaudhary G et al A rare cause of cardiomegaly Journal of the American College of Cardiology dx.doi.org/10.1016/j. ...
https://pmj.bmj.com/content/88/1045/673.responses
Cardiomegaly | Radiology Reference Article | Radiopaedia.orgCardiomegaly | Radiology Reference Article | Radiopaedia.org
Cardiomegaly is a catch-all term to refer to enlargement of the heart, and should not be confused with causes of enlargement of ... Cardiomegaly is a catch-all term to refer to enlargement of the heart, and should not be confused with causes of enlargement of ... Although in most cases merely eye-balling a chest x-ray will be sufficient in detecting cardiomegaly (as in most cases the ...
https://radiopaedia.org/articles/cardiomegaly?lang=us
Cardiomegaly | Profiles RNSCardiomegaly | Profiles RNS
Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of ... "Cardiomegaly" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Cardiomegaly" by people in this website by year, and whether " ... Below are the most recent publications written about "Cardiomegaly" by people in Profiles. ...
https://profiles.umassmed.edu/display/119660
A 10-year-old girl being evaluated for cardiomegaly | Lurie ChildrensA 10-year-old girl being evaluated for cardiomegaly | Lurie Children's
Research InnovationPublications A 10-year-old girl being evaluated for cardiomegaly ...
https://www.luriechildrens.org/en/research/publications/a-10-year-old-girl-being-evaluated-for-cardiomegaly/
cardiomegaly - Word of the Day - English - The Free Dictionary Language Forumscardiomegaly - Word of the Day - English - The Free Dictionary Language Forums
cardiomegaly. (noun) An abnormal enlargement of the heart.. Synonyms: enlarged heart, megacardia, megalocardia. Usage: The ... cardiomegaly. Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.. car·di·o·meg·a·ly (kär′dē-ō-mĕg′ə-lē). n. ... cardiomegaly. Medicine. an abnormal enlargement of the heart.. See also: Heart. -Ologies & -Isms. Copyright 2008 The Gale Group ... The Free Dictionary Language Forums » English » The Free Dictionary Daily Feed » Word of the Day » cardiomegaly ...
http://forum.thefreedictionary.com/postsm1006263_cardiomegaly.aspx
William Liby (21) died from chronic alcoholism with cardiomegaly - MyDeathSpace.comWilliam Liby (21) died from chronic alcoholism with cardiomegaly - MyDeathSpace.com
Cause of Death: Natural-chronic alcoholism with cardiomegaly. Location: Denton, TX. URL: view their profile ...
http://www.mydeathspace.com/article/2020/07/06/William_Liby_
Cardiomegaly and Vasoactive Hormones in Rats with Chronic Myocardial Infarction: Long-Term Effects of Chlorothiazide | Clinical...Cardiomegaly and Vasoactive Hormones in Rats with Chronic Myocardial Infarction: Long-Term Effects of Chlorothiazide | Clinical...
Cardiomegaly and Vasoactive Hormones in Rats with Chronic Myocardial Infarction: Long-Term Effects of Chlorothiazide Masahiro ... Cardiomegaly and Vasoactive Hormones in Rats with Chronic Myocardial Infarction: Long-Term Effects of Chlorothiazide. Clin Sci ...
https://portlandpress.com/clinsci/article-abstract/90/1/31/76240/Cardiomegaly-and-Vasoactive-Hormones-in-Rats-with?redirectedFrom=fulltext
Heart: right-sided cardiomegaly (hepatomegaly) - radiograph illustration | dogs | Vetlexicon Canis from Vetstream | Definitive...Heart: right-sided cardiomegaly (hepatomegaly) - radiograph illustration | dogs | Vetlexicon Canis from Vetstream | Definitive...
... right-sided cardiomegaly (hepatomegaly) - radiograph, illustration relating to dogs including description, information, related ...
https://www.vetstream.com/treat/canis/illustration/heart-right-sided-cardiomegaly-
MedPix Case - Cardiomegaly (CHF)MedPix Case - Cardiomegaly (CHF)
Cardiomegaly with right lung consolidation/effusion. Heart measures approx 16.6cm x 12.2 cm x 13.1 cm (LAT x A-P x C-C) at ...
https://medpix.nlm.nih.gov/case?id=052cbfa0-d4d4-43cd-9deb-4779cf94def0&quiz=t
Should be concerned about Atherosclerotic vascular calcification and Mild cardiomegaly in a scan? - Answered by top doctors on...Should be concerned about Atherosclerotic vascular calcification and Mild cardiomegaly in a scan? - Answered by top doctors on...
Some calcification is to be expected because we are Americans and eat too much dairy but ,a href="/topics/cardiomegaly" track_ ... Now a has cardiomegaly, vascular conjestion & lungs with water. more If a had 1st attack in nov 2011 2nd in may 2012. Now a has ... I had an X-ray done in the ER a couple of nights ago results: Cardiomegaly with suspected mild central vascular c more I had an ... She had cardiomegaly and vascular congest more My mother was suffering from dengue. Her platelates had come upto 5000. She had ...
https://www.healthtap.com/user_questions/6753216-should-be-concerned-about-atherosclerotic-vascular-calcification-and-mild-cardiomegaly-in-a-scan
March 2014 ECG is normal. im afraid i have cardiomegaly. i measured my apical pulse when lying left side think its |3cm in...March 2014 ECG is normal. im afraid i have cardiomegaly. i measured my apical pulse when lying left side think its |3cm in...
Pizzo responded: Cardiomegaly. Suggest you obtain a medical opinion from a doctor who can examine you, and not try to self ... I can feel my heart moving while lying on left side whem i touch my ribs.is normal?do i have cardiomegaly?so afr more I can ... In brief: Cardiomegaly Suggest you obtain a medical opinion from a doctor who can examine you, and not try to self diagnosis ... In brief: Cardiomegaly Suggest you obtain a medical opinion from a doctor who can examine you, and not try to self diagnosis ...
https://www.healthtap.com/user_questions/6622360-march-2014-ecg-is-normal-im-afraid-i-have-cardiomegaly-i-measured-my-apical-pulse-when-lying-left
Cardiomegaly Meaning in Urdu - دل کا بڑھنا Meaning, English to Urdu DictionaryCardiomegaly Meaning in Urdu - دل کا بڑھنا Meaning, English to Urdu Dictionary
Definition Synonyms at English to Urdu dictionary gives you the best and accurate urdu translation and meanings of Cardiomegaly ... Cardiomegaly meaning in Urdu: دل کا بڑھنا - meaning, ... CARDIOMEGALY MEANING IN URDU Cardiomegaly meaning in Urdu is دل ... CARDIOMEGALY Synonyms & Definition Trending Words in News: Cardiomegaly. The word Cardiomegaly is tredning recently in news and ... Cardiomegaly Meaning in Urdu. Cardiomegaly Meaning in Urdu - In the age of digital communication, it is better for any person ...
https://hamariweb.com/dictionaries/cardiomegaly_urdu-meanings.aspx
2101.07606v1] Deep Learning Models for Calculation of Cardiothoracic Ratio from Chest Radiographs for Assisted Diagnosis of...2101.07606v1] Deep Learning Models for Calculation of Cardiothoracic Ratio from Chest Radiographs for Assisted Diagnosis of...
... we hope to mitigate human subjectivity arising out of visual assessment in the detection of cardiomegaly. Comments: 6 pages. ... Deep Learning Models for Calculation of Cardiothoracic Ratio from Chest Radiographs for Assisted Diagnosis of Cardiomegaly. ... propose an automated method based on deep learning to compute the cardiothoracic ratio and detect the presence of cardiomegaly ...
http://export.arxiv.org/abs/2101.07606v1
X-ray showed mild cardiomegaly, aorta unfolding. Meaning and its cure? - Doctors insight on HealthcareMagicX-ray showed mild cardiomegaly, aorta unfolding. Meaning and its cure? - Doctor's insight on HealthcareMagic
Meaning and its cure? . Ask a Doctor about diagnosis, treatment and medication for Cardiomegaly, Ask a Cardiologist ... Cardiomegaly literally means a big heart. Mild cardiomegaly in a plain X-ray chest means the heart shadow looks a bit larger ... Cardiomegaly literally means a big heart. Mild cardiomegaly in a plain X-ray chest means the heart shadow looks a bit larger ... An X ray of chest indicated mild cardiomegaly and unfolding of aorta noted. What does this mean and what are its consequences ...
https://www.healthcaremagic.com/questions/X-ray-showed-mild-cardiomegaly-aorta-unfolding-Meaning-and-its-cure/326516
AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
CardiomegalyHydrops FetalisCardiomegaly, Exercise-InducedJamaicaRadiography, ThoracicCardiomyopathiesArteriovenous FistulaPericardial EffusionChagas CardiomyopathyFetal DiseasesUltrasonography, PrenatalHeart NeoplasmsHeart FailureFatal OutcomeElectrocardiographyEchocardiographyHeart Defects, CongenitalMyocardiumPregnancyRetrospective StudiesInfant, NewbornHypertensionPrognosisStudentsNursesEncyclopedias as TopicRisk FactorsMedical Missions, OfficialNaval MedicineFractures, CompressionVertebroplastyPleural EffusionPulmonary AtelectasisSpinal Cord CompressionAnemiaPercussionPulmonary Disease, Chronic ObstructiveDyspneaInternal MedicineThoracic Surgical ProceduresDyspnea, ParoxysmalAngina PectorisLymphedemaVirus DiseasesWorkloadHeartTerminology as TopicCopyrightDictionaries, MedicalDictionaries as TopicNigeriaDictionaries, ChemicalDiagnostic and Statistical Manual of Mental Disorders
Coronary arteryCardiacOne'sCommonlyConditionTreatmentTypeContentPeopleTerm cardiomegalyCardiomyopathyTypes of cardiomegalyPrevent cardiomegalyCommon type of cardiomegalyFamily history of cardiomegalyCardiothoracic ratioPatent Ductus ArtSymptoms of Enlarged HeartRadiographsCases of cardiomegalyEnlargement of the heartIdiopathicDefinitionTreatments2017HepatomegalyDiseasePulmonary congestionPleural effusionMedicallySyndrome2020Myocardial InfarctionShortnessHypertensivePathologyAsymptomaticDiseasesLeft ventriclePacemakerEtiologyDilationHyperthyroidismVascularSevereChronicSymptomApicalDiureticsDetectionMeaningPump
Coronary artery2
  • [13] Cardiomegaly is not a disease but rather a condition that can result from a host of other diseases such as obesity or coronary artery disease. (wikipedia.org)
  • Non-lifestyle risk factors include family history of cardiomegaly, coronary artery disease (CAD), congenital heart failure, Atherosclerotic disease, valvular heart disease, exposure to cardiac toxins, sleep disordered breathing (such as sleep apnea), sustained cardiac arrhythmias , abnormal electrocardiograms , and cardiomegaly on chest X-ray. (wikipedia.org)
Cardiac1
  • Recent studies suggest that cardiomegaly is associated with a higher risk of sudden cardiac death (SCD). (wikipedia.org)
One's1
  • If a person has a family history of cardiomegaly, one should let one's doctor know so that treatments can be implemented to help prevent worsening of the condition. (wikipedia.org)
Commonly1
  • The term cardiomegaly most commonly refers to an enlarged heart. (mercy.net)
Condition3
  • Cardiomegaly is a medical condition in which the heart is enlarged. (wikipedia.org)
  • [12] Having an immediate family member who has or had cardiomegaly may indicate that a person is more susceptible to getting this condition. (wikipedia.org)
  • Cardiomegaly is a condition affecting the cardiovascular system, specifically the heart. (wikipedia.org)
Treatment1
  • Cardiomegaly may improve over time, but many people with an enlarged heart need lifelong treatment with medications. (wikipedia.org)
Type1
  • Dilated cardiomyopathy is the most common type of cardiomegaly. (wikipedia.org)
Content1
  • Please submit any comments about the article Cardiomegaly The StatPearls content team will be working hard to evaluate the comment and make corrections when appropriate. (statpearls.com)
People1
Term cardiomegaly6
  • The term cardiomegaly most commonly refers to an enlarged heart. (mercy.net)
  • The term "cardiomegaly" most commonly refers to an enlarged heart seen on a chest X-ray. (sporthearts.org)
  • In medical field term cardiomegaly is referred to a condition where abnormal enlargement of heart is observed. (epainassist.com)
  • The term Cardiomegaly means an enlarged heart. (hxbenefit.com)
  • What is the suffix of the term cardiomegaly? (weegy.com)
  • The suffix of the term cardiomegaly is: -MEGALY. (weegy.com)
Cardiomyopathy9
  • Dilated cardiomyopathy is the most common type of cardiomegaly. (wikipedia.org)
  • Cardiomegaly is an enlarged heart and a symptom of cardiomyopathy, or disease of the heart. (livestrong.com)
  • The treatment for cardiomegaly depends on the type of cardiomyopathy and underlying disease process. (livestrong.com)
  • Currently in cardiology practice there is a significant increase in the incidence of cardiomyopathy of alcoholic origin, which inevitably provokes the development of cardiomegaly due to a significant expansion of the cavities of the heart.This clinical variant cardiomegaly has extremely poor prognosis and high mortality caused by complications of accession. (diets-doctor.com)
  • When dilation is the primary etiological reason as to why a person suffers Cardiomegaly, it is then medically labeled as congestive cardiomyopathy or DCM, otherwise known as dilated Cardiomegaly. (healthzene.com)
  • Chest x-ray - Cardiomegaly x-ray will help detect dilated cardiomyopathy as manifested by increased in the size of the heart. (healthool.com)
  • Plain radiograph pericardial calcification pulmonary edema pulmonary ossification : due to mitral valve disease 4 cardiomegaly global cardiomegaly from a dilated cardiomyopathy [radiopaedia.org] Echocardiography evaluation showed thickened aortic and mitral valve leaflets with mild to moderate degree of mitral regurgitation. (symptoma.com)
  • Although relatively rare in cats, dilated cardiomyopathy - or DCM - is an example of this type of cardiomegaly. (petcarerx.com)
  • Cardiomegaly can also be caused by certain health conditions, including hypertension , hyperthyroidism , kidney failure , and in the case of dilated cardiomyopathy, a deficiency of the essential amino acid taurine. (petcarerx.com)
Types of cardiomegaly2
  • In the other types of cardiomegaly, the heart's large muscular left ventricle becomes abnormally thick. (gutenberg.org)
  • A cat with an enlarged heart is at risk for developing a number of health problems, and as a pet parent it is useful to be aware of the different types of cardiomegaly, the dangers, and what you can do to prevent and treat the condition. (petcarerx.com)
Prevent cardiomegaly3
  • Lifestyle factors which can help prevent cardiomegaly include eating a healthy diet, controlling blood pressure, exercise, medications, and not abusing alcohol and cocaine. (wikipedia.org)
  • Case Study in Data Analysis Does a drug prevent cardiomegaly in heart failure? (docplayer.net)
  • The best way to prevent cardiomegaly is to visit your vet for regular check-ups . (petcarerx.com)
Common type of cardiomegaly1
  • The most common type of cardiomegaly, it is characterized by a thickening of the heart muscle tissue in response to a heavy workload. (petcarerx.com)
Family history of cardiomegaly2
  • If a person has a family history of cardiomegaly, one should let one's doctor know so that treatments can be implemented to help prevent worsening of the condition. (wikipedia.org)
  • Those who have a family history of cardiomegaly are at risk. (healthool.com)
Cardiothoracic ratio6
  • Cardiomegaly is a condition wherein the heart enlarges in a cardiothoracic ratio of more than 0.50. (lymphedemapeople.com)
  • Although in most cases merely 'eye-balling' a chest x-ray will be sufficient in detecting cardiomegaly (as in most cases the heart is either clearly normal in size or clearly abnormally enlarged) when unsure the cardiothoracic ratio can be measured. (radiopaedia.org)
  • We propose an automated method based on deep learning to compute the cardiothoracic ratio and detect the presence of cardiomegaly from chest radiographs. (arxiv.org)
  • By providing a numeric measurement of the cardiothoracic ratio, we hope to mitigate human subjectivity arising out of visual assessment in the detection of cardiomegaly. (arxiv.org)
  • If cardiothoracic ratio is greater than 0.5, then suggest cardiomegaly. (acrdsi.org)
  • Study Objective: This study is to ascertain the normal mean value in cardiothoracic ratio of Ghanaians using chest radiography to serve as baseline for screening for cardiomegaly. (edu.gh)
Patent Ductus Art1
  • Many infants with Cantú syndrome are born with a heart defect such as an enlarged heart (cardiomegaly) or patent ductus arteriosus (PDA). (medlineplus.gov)
Symptoms of Enlarged Heart1
Radiographs1
  • Serial chest radiographs demonstrated progressive cardiomegaly with mediastinal widening. (semanticscholar.org)
Cases of cardiomegaly1
  • Many cases of cardiomegaly are congenital, meaning that the enlarged heart is caused by structural problems that have been inherited and/or present since birth. (petcarerx.com)
Enlargement of the heart3
Idiopathic1
  • idiopathic cardiomegaly version is a rarity, but now, thanks to the use of highly accurate diagnostic methods can be detected even fetal cardiomegaly.The appearance of cardiomegaly congenital form is triggered by inherited genetic factors, in this connection, the outlook for the maintenance of normal quality of life of these patients is extremely doubtful. (diets-doctor.com)
Definition1
  • Cardiomegaly meaning in Urdu is دل کا بڑھنا, where Cardiomegaly synonym is and also find here definition and translation of Cardiomegaly. (hamariweb.com)
Treatments2
  • What Are the Treatments for Cardiomegaly? (livestrong.com)
  • The diuretics furosemide, spironolactone and hydrochlothiazide can be used as treatments for cardiomegaly. (livestrong.com)
20171
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/731709/all/cardiomegaly. (tabers.com)
Hepatomegaly1
  • Eventually, the RV fails, which manifests as hepatomegaly and/or ascites, edema of the extremities, and cardiomegaly on radiography. (symptoma.com)
Disease8
  • [13] Cardiomegaly is not a disease but rather a condition that can result from a host of other diseases such as obesity or coronary artery disease. (wikipedia.org)
  • Cardiomegaly (enlarged heart) isn't a disease on its own, but rather a symptom of another condition. (selfgrowth.com)
  • An enlarged heart (cardiomegaly) isn't a disease, but rather a symptom of another condition. (sporthearts.org)
  • Cardiomegaly - this change in the form of parameters and the total weight of the heart in the direction of increasing these parameters, which is the main manifestation of chronic heart and sometimes noncardiac abnormalities.In most situations, this term is meant not a separate disease entities, and the syndrome. (diets-doctor.com)
  • The symptoms that are associated with Cardiomegaly will greatly depend on the severity and etiological factors that are linked with this kind of disease condition. (healthzene.com)
  • It can be used as a quick initial screening tool for cardiomegaly, which in and of itself can be used as a marker for heart disease. (acrdsi.org)
  • Cardiomegaly is not a disease itself but a manifestation of an underlying health condition. (healthool.com)
  • Pimobendan helps prolong the symptom-free period for dogs with pre-clinical degenerative valve disease and cardiomegaly - EPIC Trial results. (medvetforpets.com)
Pulmonary congestion1
  • At the age of 4 years, severe osteoporosis and cardiomegaly with pulmonary congestion were observed in the child. (hindawi.com)
Pleural effusion1
  • Because her chest radiography showed cardiomegaly and left-sided pleural effusion with small atelectasis, transthoracic echocardiography and contrast enhanced chest CT were performed ( figure 1 , see online supplementary video ). (bmj.com)
Medically1
Syndrome2
  • A particular kind of dwarfism called morquio syndrome or otherwise known as mucopolysaccharidosis IV can result in Cardiomegaly. (healthzene.com)
  • The hypertrichosis and osteochondrodysplasia syndrome is a rare entity with clinical findings including macrosomia at birth cardiomegaly. (udg.mx)
20202
  • Cardiomegaly meaning in Urdu has been searched 2092 (two thousand and ninety-two) times till Mar 30, 2020. (hamariweb.com)
  • 2020. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688096/all/Cardiomegaly. (unboundmedicine.com)
Myocardial Infarction1
  • People with myocardial infarction are at risk for cardiomegaly. (healthool.com)
Shortness1
  • Controlling a patient's fluid volume helps maintain a stable blood pressure and relieves the symptoms of shortness of breath, fatigue and cough caused by cardiomegaly. (livestrong.com)
Hypertensive1
  • Hypertension occurs when there is high blood pressure, causing the heart difficulty pumping blood throughout the body, making the heart muscle thicker and eventually leading to a hypertensive kind of Cardiomegaly. (healthzene.com)
Pathology1
  • cardiomegaly are both innate and acquired types, so this pathology can occur in patients of different age groups. (diets-doctor.com)
Asymptomatic3
  • For many people, cardiomegaly is asymptomatic . (wikipedia.org)
  • Some people affected with Cardiomegaly are usually asymptomatic, meaning they do not suffer from any symptoms. (hxbenefit.com)
  • Cardiomegaly in its early stage can be quite difficult to diagnose considering that it is mostly asymptomatic. (healthool.com)
Diseases1
Left ventricle1
  • A contrast CT revealed cardiomegaly and a filling defect in the left atrium extending through the left ventricle. (symptoma.com)
Pacemaker1
  • When medications are not enough to control the symptoms of cardiomegaly, a pacemaker may be inserted to help synchronize the beating action of the heart. (livestrong.com)
Etiology1
  • IMSEAR at SEARO: Cardiomegaly of unknown etiology in a family. (who.int)
Dilation2
  • Cardiomegaly with marked biventricular dilation and fibrosis were noticeable histopathological findings. (symptoma.com)
  • There was generalized cardiomegaly with dilation of the pulmonary vessels. (balkanvets.com)
Hyperthyroidism1
  • Hypothyroidism and hyperthyroidism leads to Cardiomegaly. (healthzene.com)
Vascular1
  • Does cardiomegaly, vascular congestion and lungs filled with water cause death my mother died because of these? (healthtap.com)
Severe1
  • [ncbi.nlm.nih.gov] Oral prednisone is useful in patients with severe form of carditis, characterized by cardiomegaly and congestive heart failure. (symptoma.com)
Chronic2
Symptom2
Apical1
  • To assess the accuracy of precordial percussion and apical impulse palpation in detecting cardiomegaly radiographically. (annals.org)
Diuretics2
  • Diuretics are prescribed for enlarged heart or cardiomegaly as they control the level of water and sodium in the body. (epainassist.com)
  • If Cardiomegaly is caused by high blood pressure , beta blockers, angiotensin-converting enzyme (ACE) inhibitors and diuretics may be used to reduce pressure level. (hxbenefit.com)
Detection1
  • Prevention of cardiomegaly starts with detection. (wikipedia.org)
Meaning2
  • Cardiomegaly Meaning in Urdu - In the age of digital communication, it is better for any person to learn and understand multiple languages for the better communication. (hamariweb.com)
  • The Cardiomegaly meaning in Urdu will improve your knowledge about Cardiomegaly. (hamariweb.com)
Pump2
  • Cardiomegaly weakens the heart muscle and reduces the ability of the heart to pump blood to the rest of the body. (livestrong.com)
  • With time, the pumping chambers of the failing heart may weaken and dilate, resulting in not only a further increase in heart size, cardiomegaly, but also a decreased ability to pump blood efficiently. (docplayer.net)
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The BMJ research homepage: make an impact, change clinical practice | The BMJ (bmj.com)
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Enlarged Heart Treatment and Symptoms | Livestrong.com (livestrong.com)
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What Are the Treatments for Cardiomegaly? | Livestrong.com (livestrong.com)
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Fire Fighter Fatality Investigation Report F2011-03 | NIOSH | CDC (cdc.gov)
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Fire Fighter Fatality Investigation Report F2008-30 | NIOSH | CDC (cdc.gov)
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy - Full Text View - ClinicalTrials.gov
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
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