Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.

Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. (1/1010)

We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also independently of such death receptors. Here we investigated mitochondria-dependent mechanisms of NO-induced apoptosis in Jurkat leukemic cells. NO donor glycerol trinitrate (at the concentration, which induces apoptotic cell death) caused (1) a significant decrease in the concentration of cardiolipin, a major mitochondrial lipid; (2) a downregulation in respiratory chain complex activities; (3) a release of the mitochondrial protein cytochrome c into the cytosol; and (4) an activation of caspase-9 and caspase-3. These changes were accompanied by an increase in the number of cells with low mitochondrial transmembrane potential and with a high level of reactive oxygen species production. Higher resistance of the CD95-resistant Jurkat subclone (APO-R) cells to NO-mediated apoptosis correlated with the absence of cytochrome c release and with less alterations in other mitochondrial parameters. An inhibitor of lipid peroxidation, trolox, significantly suppressed NO-mediated apoptosis in APO-S Jurkat cells, whereas bongkrekic acid (BA), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. Transfection of Jurkat cells with bcl-2 led to a complete block of apoptosis due to the prevention of changes in mitochondrial functions. We suggest that the mitochondrial damage (in particular, cardiolipin degradation and cytochrome c release) induced by NO in human leukemia cells plays a crucial role in the subsequent activation of caspase and apoptosis.  (+info)

Enzymatic properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin. (2/1010)

The recently reported heterologous expression and purification of both human cytochrome P450SCC and adrenodoxin [Woods, S.T., Sadleir, J., Downs, T., Triantopoulos, T., Haedlam, M.J. & Tuckey, R.C. (1998) Arch. Biochem. Biophys. 353, 109-115] has enabled us to perform studies with the membrane-reconstituted human enzymes to better understand the side-chain cleavage reaction in humans. Human P450SCC was successfully reconstituted into dioleoylphosphatidylcholine vesicles with and without cardiolipin and its enzymatic properties characterized in the membrane-bound state. Enhancement of the P450SCC activity and significant activation by cardiolipin were observed when human adrenodoxin instead of bovine adrenodoxin was used as electron donor. In the absence of cardiolipin, Km for cholesterol was decreased twice in the case of human adrenodoxin indicating enhanced cholesterol binding. On the other hand, in the presence of cardiolipin in the membrane both Km and V for cholesterol were decreased with human adrenodoxin as electron donor. Kinetic analysis of the interaction between human P450SCC and its redox partners provided evidence for enhanced binding of the human electron donor to human P450SCC indicated by both an increased V and decreased Kd for human adrenodoxin compared with the values with bovine adrenodoxin. Because no similar effects were observed in Tween 20 micelles, these results suggest that the phospholipid membrane may play an important role in the interaction of human adrenodoxin with human P450SCC.  (+info)

Phospholipid composition of Rickettsia prowazeki grown in chicken embryo yolk sacs. (3/1010)

The phospholipid composition and phospholipid fatty acid composition of purified Rickettsia prowazeki were determined. The lipid phosphorous content was 6.8 +/- 1.3 microgram/mg of total rickettsial protein. The major phospholipid was phosphatidylethanolamine (60 to 70%); phosphatidylglycerol constituted 20%, and phosphatidylcholine constituted 15%. Small amounts of phosphatidylserine and cardiolipin were detected. The principal fatty acids were 18:1, 16:1, and 16:0. The fatty acid composition of the phosphatidylcholine in the rickettsial extracts was very different than that of the other rickettsial phosphatides and very similar to that of normal yolk sac phosphatidylcholine. The specific of the phosphatidylcholine of rickettsiae grown in the presence of 32P was markedly lower than that of phosphatidylethanolamine and phosphatidylglycerol. It is suggested that the phosphatidylcholine in the rickettsial extract is yolk sac derived and either tightly absorbed or exchanged into the rickettsial membrane.  (+info)

Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. (4/1010)

Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a 'cofactor', identified as beta 2-glycoprotein I (beta 2-GPI), to bind phospholipids. We show here that aCL can bind beta 2-GPI in the absence of phospholipid. Binding of aCL to beta 2-GPI is dependent upon the beta 2-GPI being immobilized on an appropriate surface including cardiolipin, irradiated polystyrene and nitrocellulose membrane. This effect cannot be explained by increased antigen density of beta 2-GPI immobilized on these surfaces. Rather, conformational changes that occur following the interaction of beta 2-GPI with phospholipid render this protein antigenic to aCL. Liquid-phase beta 2-GPI was not antigenic for aCL. Thus, aCL cannot bind circulating beta 2-GPI. These findings may explain why patients with aCL can remain healthy for many years but then undergo episodes of thrombosis or fetal loss without changes in their circulating aCL profile, as the triggering event for these pathologies can be predicted to be one that renders beta 2-GPI antigenic for aCL.  (+info)

Transbilayer movement and distribution of spin-labelled phospholipids in the inner mitochondrial membrane. (5/1010)

The transmembrane diffusion and equilibrium distribution of spin-labelled phosphatidylethanolamine (PE*), phosphatidylcholine (PC*) and cardiolipin (CL*) were investigated in purified mitochondrial inner membranes using electron spin resonance spectroscopy. Using the back exchange technique, we found that the outside-inside movement of PE* and PC* in beef-heart inner mitochondrial membranes was rapid (t1/2 in the range 10-15 min at 30 degrees C). The steady-state distributions in non-energised mitoplasts were approximately 30% in the inner leaflet for PC* and 39% for PE*. Within the limits of probe concentration that can possibly be used in these experiments, the initial velocity of the inward movement was not saturable with respect to the amount of analogue added to the membranes, suggesting that the spin-labelled phospholipids diffused passively between the two leaflets of the inner mitochondrial membrane. In energised mitoplasts, PC* behaviour was not affected, PE* diffused approximately two times faster toward the inner monolayer but reached the same plateau. Treatment of energised mitochondria with N-ethylmaleimide did not affect PC* diffusion, while the kinetics of PE* internalisation became identical to that of PC*. Similar results were found when PC* and PE* movements were studied in mitoplasts from beef heart, rat liver or yeast. The spin-labelled cardiolipin, which possesses four long chains, had to be introduced in the mitoplast with some ethanol. After equilibration (t1/2 of the order of 13 min at 30 degrees C), the transmembrane distribution suggested that approximately half of the cardiolipin analogue remained in the outer leaflet. These results do not allow us to determine if a specific protein (or flippase) is involved in the phospholipid transmembrane traffic within inner mitochondrial membranes, but they show that lipids can rapidly flip through the mitochondrial membrane.  (+info)

Involvement of Arg-328, Arg-334 and Arg-342 of DnaA protein in the functional interaction with acidic phospholipids. (6/1010)

We reported previously that three basic amino acids (Arg-360, Arg-364 and Lys-372) of DnaA protein are essential for its functional interaction with cardiolipin. In this study, we examined the effect of mutation of some basic amino acids in a potential amphipathic helix (from Lys-327 to Ile-345) of DnaA protein on this interaction. ATP binding to the mutant DnaA protein, in which Arg-328, Arg-334 and Arg-342 were changed to acidic amino acids, was less inhibited by cardiolipin than that of the wild-type protein, as was the case for mutant DnaA protein with mutations of Arg-360, Arg-364 and Lys-372. A mutant DnaA protein with mutations of all six basic amino acids showed the most resistance to the inhibition of ATP binding by cardiolipin. These results suggest that Arg-328, Arg-334 and Arg-342, like Arg-360, Arg-364 and Lys-372, are also involved in the functional interaction between DnaA protein and acidic phospholipids.  (+info)

Maternal cardiolipin, beta 2-glycoprotein-I and prothrombin antibody expression in high-risk pregnancies with bilateral abnormal uterine artery Doppler waveforms. (7/1010)

OBJECTIVE: To compare the frequency of maternal serum antiphospholipid antibodies (to cardiolipin, beta 2-glycoprotein I and prothrombin) in pregnancies presenting with bilateral abnormal uterine artery Doppler waveforms. DESIGN: Retrospective analysis of stored serum. SUBJECTS: Cases comprised 47 singleton pregnancies with bilateral abnormal uterine artery Doppler waveforms at 24 weeks of gestation, followed from 20 weeks, and controls were 100 healthy pregnancies with normal uterine artery Doppler waveforms. METHODS: Ultrasound examination utilized a 5-MHz curvilinear transabdominal transducer with pulsed and color Doppler facilities. Antiphospholipid antibodies were analyzed by ELISA methodology, and reference ranges were established using the geometric mean +/- 2 SD of healthy non-pregnant adults. Human chorionic gonadotropin (hCG) levels were obtained from patient notes. RESULTS: Anticardiolipin antibodies were detected in 11 (23%) of the cases (IgG, n = 7; IgM, n = 6) compared with ten (10%) of the controls (p < 0.05). Low titer anticardiolipin IgG (range, 5.5-35.3; median, 6.3 GPL units) and anticardiolipin IgM (range, 3.4-14.7; median, 5.3 MPL units) were detected in cases. Amongst the cases, adverse perinatal outcomes were more common in the presence of raised levels of anticardiolipin antibodies. Anti-beta 2-glycoprotein I IgG was not detected in any of the cases. Antiprothrombin IgG was not detected, but antiprothrombin IgM occurred in 10.6% of cases compared with 2% of controls. CONCLUSIONS: Women with persistent bilateral abnormal uterine artery. Doppler waveforms in mid-gestation were more likely to express raised levels of anticardiolipin antibodies than healthy controls with normal uteroplacental perfusion. Anticardiolipin antibodies without anti-beta 2-glycoprotein I binding may be involved in the pathogenesis of uteroplacental ischemia in a proportion of high-risk pregnancies.  (+info)

Polar lipids of four Listeria species containing L-lysylcardiolipin, a novel lipid structure, and other unique phospholipids. (8/1010)

The membrane lipids of Listeria innocua, Listeria monocytogenes, Listeria seeligeri and Listeria welshimeri were fractionated on DEAE-cellulose and purified by chromatography on silica gel and/or preparative TLC. The lipid structures were elucidated by chemical and chromatographic means. The polar lipid composition of the four listeria species was similar. Phospholipids predominated. They consisted of phosphatidylglycerol, L-lysylphosphatidylglycerol, cardiolipin [bis(phosphatidyl)glycerol] and L-lysylcardiolipin. A phospholipid more polar than cardiolipin, possibly two L-lysyl derivatives of it, sn-glycero-1-phosphoglycolipid, its D-alanyl derivative, and polyprenol phosphate were also detected. Towards the end of exponential growth, the relative amounts of cardiolipin and L-lysylcardiolipin increased, approaching 47-78% lipid phosphorus with a ratio of L-lysylcardiolipin to cardiolipin of 0.25-1.6. As shown by fast atom bombardment-mass spectrometry, cardiolipin and L-lysylcardiolipin consisted of five molecular species due to various fatty acid combinations. L-lysylcardiolipin has so far not been found in nature. It belongs to the recently discovered class of substituted cardiolipins. Its occurrence in the four listeria species tested shows that it is a characteristic lipid component of the L. monocytogenes line of descent. Further studies on the lipid pattern of members of the other descent line are required to decide whether lysylcardiolipin can serve as a genus-specific chemotaxonomic marker for listeriae.  (+info)

Cardiolipins are a type of phospholipid that are primarily found in the inner mitochondrial membrane of cells. They play a crucial role in several important cellular processes, including energy production, apoptosis (programmed cell death), and maintenance of the structural integrity of the mitochondria.

Cardiolipins are unique because they contain four fatty acid chains, whereas most other phospholipids contain only two. This gives cardiolipins a distinctive conical shape that is important for their function in maintaining the curvature and stability of the inner mitochondrial membrane.

Cardiolipins have also been implicated in various diseases, including neurodegenerative disorders, cancer, and bacterial infections. For example, changes in cardiolipin composition or distribution have been linked to mitochondrial dysfunction in Parkinson's disease and other neurological conditions. Additionally, certain bacteria, such as Neisseria gonorrhoeae and Chlamydia trachomatis, can manipulate host cell cardiolipins to facilitate their own survival and replication.

In summary, cardiolipins are essential phospholipids found in the inner mitochondrial membrane that play a critical role in several cellular processes, and have been implicated in various diseases.

... from a cow heart is used as an antigen in the Wassermann test for syphilis. Anti-cardiolipin antibodies can also be ... 2009;23(4):210-2. Cardiolipin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Cardiolipin ( ... Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. Because of cardiolipin's unique ... The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. Catabolism of cardiolipin may ...
... (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In ... In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ...
Cardiolipins are a subclass of glycerophospholipids containing four acyl chains and three glycerol groups that are particularly ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-2165 ... Hoch FL (March 1992). "Cardiolipins and biomembrane function" (PDF). Biochimica et Biophysica Acta (BBA) - Reviews on ...
Cardiolipin contains four fatty acids rather than two, and may help to make the inner membrane impermeable, and its disruption ... McMillin JB, Dowhan W (December 2002). "Cardiolipin and apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered ... "Advances in methods to analyse cardiolipin and their clinical applications". Trends in Analytical Chemistry. 157: 116808. doi: ...
It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida. Archaea do not generally ... Mühleip A, McComas SE, Amunts A (November 2019). "Structure of a mitochondrial ATP synthase with bound native cardiolipin". ...
A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861-31870. doi:10.1074/jbc.m300190200. PMID 12805375 ...
Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...
Other members of this family are able hydrolyze other phospholipid substrates, such as cardiolipin, or even the phosphodiester ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. thesis). RWTH-Aachen University ... PLD5 PC-hydrolyzing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins ...
Nowicki M (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...
... and its overexpression in cultured cells resulted in increased cardiolipin synthase activity. As cardiolipin is synthesized in ... The active t-Bid fragment is shown to localize to mitochondria through a positive interaction with cardiolipin. This activated ... M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... Recent findings suggest that PLSCR3 is involved in regulation of biosynthesis of cardiolipin in mitochondria, ...
... and cardiolipin is oxidized by a peroxidase function of the cardiolipin-cytochrome c complex. The hemoprotein is then detached ... Cytochrome c binds to cardiolipin in the inner mitochondrial membrane, thus anchoring its presence and keeping it from ... While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on ... Orrenius S, Zhivotovsky B (September 2005). "Cardiolipin oxidation sets cytochrome c free". Nature Chemical Biology. 1 (4): 188 ...
Ye C, Shen Z, Greenberg ML (April 2016). "Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and ... Barth syndrome patients exhibit defects in cardiolipin metabolism, including aberrant cardiolipin fatty acyl composition, ... After its synthesis, cardiolipin cannot exert its proper functions until it is actively remodeled. Tafazzin, an acyl-specific ... Cardiolipin is a complex glycerophospholipid which contains four acyl groups linked to three glycerol moietie localized in the ...
Erythrocyte sedimentation rate was elevated at 35 mm/hour; cardiolipin IgM was weakly positive at 16.3; C4 was decreased at 10 ...
A membrane lipid cardiolipin is exclusively found in the inner mitochondrial membrane and bacterial cell membranes. Some ... Mileykovskaya, E.; Dowhan, W. (October 2009). "Cardiolipin membrane domains in prokaryotes and eukaryotes". Biochimica et ... that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell membranes; and that some mitochondria and ...
It can stain cardiolipin content of mitochondria. North Atlantic oscillation, a climatic phenomenon Nao (robot), a humanoid ...
Mileykovskaya, E; Dowhan, W (2009). "Cardiolipin Membrane Domains in Prokaryotes and Eukaryotes". Biochimica et Biophysica Acta ...
One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in ... Borchman D, Harris EN, Pierangeli SS, Lamba OP (1995). "Interactions and molecular structure of cardiolipin and beta 2- ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin ...
The main phospholipids are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. Ectoine, glutamate, and, to a ...
Identify via agglutination with cardiolipin sensitive chicken erythrocytes. RCN infected Strain 143 human osteosarcoma cells ...
In addition it contains cardiolipin and phosphatidylcholine as the major phospholipids, while sterols are absent. Cardiolipin ...
... combines with CDP-DAG forming cardiolipin releasing CMP by the action of cardiolipin synthase. Two ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... In eukaryotic mitochondria phosphatidylglycerol is converted to cardiolipin by reacting with a molecule of cytidine diphosphate ...
Alpha helices 2 and 3 bind to cardiolipin. The UQCC3 gene encodes a protein that functions in complex III assembly, downstream ... Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L (April 2015). "C11orf83, a mitochondrial cardiolipin-binding ... Depletion of this protein alters cardiolipin composition, causing cellular and mitochondrial defects. The UQCC3 gene is located ... Depleted levels of the UQCC3 protein cause impaired respiration and subtle yet significant alterations in cardiolipin ...
Yadav, Pradeep Kumar; Rajasekharan, Ram (2017). "Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces ...
Pan, Ronghui; Jones, A. Daniel; Hu, Jianping (2014-02-28). "Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in ...
Cardiolipin is intimately connected with the electron transport chain proteins and the membrane structure of the mitochondrion ... Kulik found that every patient with Barth Syndrome that he tested had abnormalities in their cardiolipin, a lipid found inside ... Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM (December 2008). "The cardiolipin transacylase, tafazzin, ... December 2000). "Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome". Biochemical and Biophysical ...
Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria, ... cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. In the inner mitochondrial membrane, the protein-to- ...
Although MLCL AT-1 and MTP are different proteins, in 2012 the same lab discovered that MTP did indeed have cardiolipin ... This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation. Disorders associated MTP ... "Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation". PLOS ONE. 7 (11): e48628. Bibcode:2012PLoSO ... linking MTP to the remodeling of cardiolipin from monolysocardiolipin. ...
... into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which ... producing cardiolipin. This lipid remodeling is separate from the cardiolipin synthesis pathway, and is essential to maintain ... Since cardiolipin content is significantly diminished in the inner mitochondrial membrane during apoptosis, the increase of ... Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM (2012). "Human trifunctional protein alpha links cardiolipin ...
Corcelli, Angela; Schlame, Michael (2016-06-01). "Cardiolipin as key lipid of mitochondria in health and disease. 2nd Edition, ...
This composition of fatty acyl is also known as tetralinoleoyl cardiolipin (TLCL). However, newly synthesized cardiolipin, also ... leading to cardiolipins with not only non-optimal functionality compared to that of tetralinoleoyl cardiolipin (TLCL), but also ... leading to tetralinoleoyl cardiolipins (TLCL) depletion. That renders cardiolipins high sensitivity to oxidative damage by ... Cao J, Liu Y, Lockwood J, Burn P, Shi Y (July 2004). "A novel cardiolipin-remodeling pathway revealed by a gene encoding an ...
Cardiolipin from a cow heart is used as an antigen in the Wassermann test for syphilis. Anti-cardiolipin antibodies can also be ... 2009;23(4):210-2. Cardiolipin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Cardiolipin ( ... Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. Because of cardiolipins unique ... The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. Catabolism of cardiolipin may ...
Quality Cardiolipin IgG, A, M ELISA kit kit from ELISA kits manufacturer and elisa kits supplier including Cardiolipin ELISA ... Cardiolipin IgG, A, M ELISA kit description:. The Diagnostic Automation Cardiolipin IgA, G, M ELISA kit is a solid phase enzyme ... Cardiolipin IgG, A, M ELISA kit. Name. Cardiolipin IgG, A, M ELISA Test ... See the Cardiolipin Cardiolipin IgA, G, M ELISA Kit product insert for specific details on preparation, procedures, quality ...
Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how ... The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a ... Cardiolipin synthesis and remodeling regulate mitochondrial metabolic plasticity and signaling function. Mauro Corrado, PhD, ... My previous work started to shed light on the effects of cardiolipin deficiency in CD8+ T cell immune response (Corrado et al ...
Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and ...
Regulation of cardiolipin synthesis and the role of this phospholipid in adriamycin-induced cardiotoxicity ... Rua, Diego., "Regulation of cardiolipin synthesis and the role of this phospholipid in adriamycin-induced cardiotoxicity" (1999 ...
Cardiolipin. Clinical Trials. Clinical Trials Phase. Status. Purpose. Conditions. Count. Pharmacoeconomics. Manufacturers. Not ... Cardiolipins. Alternative Parents. Tetracarboxylic acids and derivatives / Fatty acid esters / Dialkyl phosphates / Secondary ... cardiolipin (CHEBI:62861) Affected organisms. Not Available. Chemical Identifiers. UNII. Not Available. CAS number. Not ... Tetrastearoyl cardiolipin. DrugBank Accession Number. DB03429. Background. Not Available. Type. Small Molecule. Groups. ...
The health content and information on this site is made possible through the generous support of the Haspel Education Fund ...
Anti-Cardiolipin IgM. Key Features and Values. - Same sample type can be used across all assays to simplify inclusion into ... Among these, the Cardiolipin is the most commonly used phospholipid as an antigen for determining the aPL by ELISA method. ... Anti Cardiolipin IgM kit is an indirect solid phase immunoassay kit for the quantitative measurement of IgM class auto- ... In 1942 it was discovered that the active component is a phospholipid called Cardiolipin. In the 1950s it was observed that a ...
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For instance, cardiolipin, an anionic phospholipid, has been found to be associated to a number of eukaryotic and prokaryotic ... Moreover, polar and septal accumulation of cardiolipin in a number of prokaryotes may ensure proper spatial segregation and/or ... In this review, we describe current knowledge of the functions associated with cardiolipin binding to respiratory complexes in ...
IgA cardiolipin antibody is occasionally detected in SLE and SLE-like patients and appears to be most commonly associated with ...
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I am working for the LOINC mapping on "anti-cardiolipin IgM" and "anti-cardiolipin IgG". Different reporting unit can be seen ...
Assembly of the Mitochondrial Cristae Organizer Mic10 is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. In: Journal of ... Assembly of the Mitochondrial Cristae Organizer Mic10 is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. Journal of ... Assembly of the Mitochondrial Cristae Organizer Mic10 is Regulated by Mic26-Mic27 Antagonism and Cardiolipin. / Rampelt, Heike ... Assembly of the Mitochondrial Cristae Organizer Mic10 Is Regulated by Mic26-Mic27 Antagonism and CardiolipinFinal publishers ...
Cardiolipin Cardiolipine IgA-Ab. Cardiolipin IgA-Ak Material. Serum: 1 ml, EDTA-Plasma, Heparin-Plasma (kein Citrat-Plasma) ...
Sathappa, Murugappan, "Analysis of the Significance of Cardiolipin in the Mitochondrial Inner Membrane and its Regulation of ... Analysis of the Significance of Cardiolipin in the Mitochondrial Inner Membrane and its Regulation of Mitochondrial ...
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The Cardiolipin antibody (IgG) test (GenBio) is an ELISA for the quantitative detection of autoimmune antibodies to cardiolipin ...
Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA. *P-ANCA ...
Anti-Cardiolipin IgA. Anti-Cardiolipin IgA ist ein auf der ELISA Technik basierendes, automatisiertes In-vitro-Testsystem für ... Anti-Cardiolipin IgG. Anti-Cardiolipin IgG ist ein auf der ELISA Technik basierendes, automatisiertes In-vitro-Testsystem für ... Anti-Cardiolipin IgM. Anti-Cardiolipin IgM ist ein auf der ELISA Technik basierendes, automatisiertes In-vitro-Testsystem für ... Anti-Cardiolipin Screen. Anti-Cardiolipin Screen ist ein auf der ELISA Technik basierendes Screening-Testsystem für die semi- ...
The interaction of mitochondrial cytochrome (cyt) c with cardiolipin (CL) is involved in the initial stages of apoptosis. This ... Interaction of Carbon Monoxide with the Apoptosis-Inducing Cytochrome c-Cardiolipin Complex ... Interaction of Carbon Monoxide with the Apoptosis-Inducing Cytochrome c-Cardiolipin Complex. Biochemistry, 48 (7). pp. 1613- ... Interaction of Carbon Monoxide with the Apoptosis-Inducing Cytochrome c-Cardiolipin Complex. Biochemistry, 48 (7). pp. 1613- ...
Cerebrospinal fluid anti-cardiolipin antibodies in patients with hiv-1 infection. Robin L. Brey*, Ramon Arroyo, R. Neal Boswell ... Cerebrospinal fluid anti-cardiolipin antibodies in patients with hiv-1 infection. / Brey, Robin L.; Arroyo, Ramon; Boswell, R. ... Cerebrospinal fluid anti-cardiolipin antibodies in patients with hiv-1 infection. In: Journal of Acquired Immune Deficiency ... Cerebrospinal fluid anti-cardiolipin antibodies in patients with hiv-1 infection. Journal of Acquired Immune Deficiency ...
  • IgA cardiolipin antibody is occasionally detected in SLE and SLE-like patients and appears to be most commonly associated with cerebrovascular thrombosis. (umich.edu)
  • What is the purpose of a cardiolipin antibody test? (ganeshdiagnostic.com)
  • The product Assay kit for Guinea pig anti-cardiolipin antibody IgG,ACA-IgG (ELISA) should be kept between two and eight degrees Celsius to ensure the retention of the stability and reactivity of the reagents included in the kit. (igganti.com)
  • The product Assay kit for Guinea pig anti-cardiolipin antibody IgG,ACA-IgG (ELISA) is intended to be used for research purposes only. (igganti.com)
  • What are the benefits of CARDIOLIPIN ANTIBODY (ACL) - IGA Full Body Checkup? (hellodox.com)
  • The Diagnostic Automation Cardiolipin IgA, G, M ELISA kit is a solid phase enzyme immunoassay employing highly purified cardiolipin plus native human Beta2-glycoprotein I for the combined semi-quantitative and qualitative detection of IgA, IgG and IgM antibodies against cardiolipin in human serum. (rapidtest.com)
  • Antibodies against cardiolipin belong to the group of anti-phospholipid antibodies specific for negatively charged phospholipids, components of biological membranes.Cardiolipin is an acidic phospholipid derived from glycerol and was named because of its isolation from bovine heart in 1941. (rapidtest.com)
  • The occurrence of anti-cardiolipin antibodies in patients with SLE and related diseases is typical for a secondary anti-phospholipid syndrome (APS). (rapidtest.com)
  • In contrast, anti-cardiolipin antibodies in patients with no other autoimmune diseases characterize the primary anti-phospholipide syndrome (APS). (rapidtest.com)
  • Anti-cardiolipin antibodies mainly recognize specific epitopes on a complex composed out of cardiolipin and Beta2-glycoprotein I which are expressed only when Beta2-glycoprotein I interacts with cardiolipin. (rapidtest.com)
  • Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and Anti-Annexin V Antibodies. (ncbcs.org)
  • Human cardiolipin screen ELISA kit is a procedure for screening in vitro quantitative concentrations of IgG, IgM and IgA auto-antibodies to screen cardiolipin (cardiolipin-IgG, cardiolipin-IgM, cardiolipin-IgA) in human serum and plasma. (elisakits.co.uk)
  • The minimum detection sensitivity level of IgG, IgA or IgM antibodies to screen cardiolipin (cardiolipin-IgG, cardiolipin-IgA, cardiolipin-IgM) using current cardiolipin ELISA kit was 1.0 U/ml. (elisakits.co.uk)
  • Anti Cardiolipin IgM kit is an indirect solid phase immunoassay kit for the quantitative measurement of IgM class auto-antibodies directed against Cardiolipin-β2-glycoprotein complex in human serum or plasma. (diametra.com)
  • REAADS Anti-Cardiolipin (aCL) IgA is an ELISA for the determination of IgA anti-cardiolipin antibodies in human serum or plasma in individuals with systemic lupus erythematosus (SLE) and lupus-like disorders (anti-phospholipid syndrome). (diapharma.com)
  • Diluted serum samples, calibrator sera, and controls are incubated in cardiolipin coated microwells, allowing aCL antibodies present in the samples to react with the immobilized antigen. (diapharma.com)
  • After the removal of unbound serum proteins by washing, antibodies specific for human IgA labeled with horseradish peroxidase (HRP) are added forming complexes with the cardiolipin bound antibodies. (diapharma.com)
  • Cardiolipin antibodies present in the sample will bind to the coated wells. (diapharma.com)
  • The blood test for cardiolipin antibodies, IgA, IgG, and IgM, is used to assess for antiphospholipid syndrome and occasionally other autoimmune illnesses, as well as to help discover the cause of recurrent miscarriage. (ganeshdiagnostic.com)
  • Tests for cardiolipin antibodies typically produce a positive or negative outcome. (ganeshdiagnostic.com)
  • By accident, the antibodies assault cardiolipins. (ganeshdiagnostic.com)
  • Why are cardiolipin antibodies so high? (ganeshdiagnostic.com)
  • How are cardiolipin antibodies managed? (ganeshdiagnostic.com)
  • Unusual cardiolipin antibodies: what are they? (ganeshdiagnostic.com)
  • Both cerebrospinal fluid (CSF) immunologic abnormalities and serum anti-cardiolipin antibodies (aCL) have been reported in patients with HIV-1 infection. (usuhs.edu)
  • Antiphospholipid antibodies, including cardiolipin, are common in lupus. (arthritis.org)
  • The RPR test measures IgM and IgG antibodies to lipoidal material released from damaged host cells, as well as to lipoprotein-like material and possibly cardiolipin released from the treponemes. (cdc.gov)
  • The aCL antibodies bind to b2GPI, or a complex formed by this b2GPI is a platelet adhesin glycoprotein and cardiolipin. (medscape.com)
  • The phospholipid cardiolipin is only found in mitochondrial membranes, making them special within the cell. (ganeshdiagnostic.com)
  • The mitochondrial signature phospholipid cardiolipin shows a stabilizing function on Mic10 oligomers. (rug.nl)
  • Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. (ku.dk)
  • Anti-Cardiolipin IgA ist ein auf der ELISA Technik basierendes, automatisiertes In-vitro-Testsystem für die quantitative Bestimmung von IgA-Antikörpern gegen Cardiolipin in humanem Serum oder Plasma. (orgentec.com)
  • Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin. (cdc.gov)
  • This strain produced triglycerides (TG) as well as four common phospholipids: phosphatidylethanolamine (PE), phosphatidylglycerol (PG), cardiolipin (CL) and lysocardiolipin (LCL). (nature.com)
  • A highly purified cardiolipin is coated on micro-wells saturated with beta-2 glycoprotein I. (elisakits.co.uk)
  • Finally, a molecule of CDP-DAG is bound to PG to form one molecule of cardiolipin, catalyzed by the mitochondria-localized enzyme cardiolipin synthase (CLS). (wikipedia.org)
  • In prokaryotes such as bacteria, diphosphatidylglycerol synthase catalyses a transfer of the phosphatidyl moiety of one phosphatidylglycerol to the free 3'-hydroxyl group of another, with the elimination of one molecule of glycerol, via the action of an enzyme related to phospholipase D. The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. (wikipedia.org)
  • Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. (ku.dk)
  • In stationary phase, cardiolipin synthase activity has been observed to increase approximately 10-fold in the Gram-negative model organism Escherichia coli , suggesting CL is an essential membrane component to cope with starvation 4 . (nature.com)
  • The interaction of mitochondrial cytochrome (cyt) c with cardiolipin (CL) is involved in the initial stages of apoptosis. (essex.ac.uk)
  • We have utilized bovine heart cardiolipin as well as commercially available tetralinoleoyl cardiolipin oxidized with cytochrome c (cyt c) and hydrogen peroxide as well as with lipoxygenase to test the separation power of the system. (cdc.gov)
  • A role of flavonoids in cytochrome c-cardiolipin interactions. (nih.gov)
  • Assays of cardiolipin_levels. (elisakits.co.uk)
  • Some researchers suggest the use of PS instead of Cardiolipin in ELISA assays, for a more precise diagnosis. (diametra.com)
  • Briefly, CD8+ T cells, responsible for fighting infections and safeguarding our organism from cancer, rely on the presence of cardiolipin and on its regulated synthesis and remodeling to properly activate, expand and eliminate pathogens or tumor cells. (barthsyndrome.org)
  • Regulation of cardiolipin synthesis and the role of this phospholipid in adriamycin-i . . ." by Diego. (wayne.edu)
  • Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. (wikipedia.org)
  • ATRA perturbs the homeostasis of numerous lipids and the most relevant effects are observed on cardiolipins, which are located in the mitochondrial inner membranes and play a role in oxidative-phosphorylation. (slub-dresden.de)
  • Alle Anti-Cardiolipin-Tests von ORGENTEC sind mit humanem beta-2-Glycoprotein I als Kofaktor beschichtet. (orgentec.com)
  • Autoantibodies (IgA/G/M) targeting cardiolipin and β 2 glycoprotein-I and specific nuclear antigens were analyzed by multiplexed bead technology. (lu.se)
  • Results: Both prevalence and titers of aPL of the IgG isotype (anti-cardiolipin and/or anti-β 2 glycoprotein-I) were higher in patients with MINOCA and MICAD than in controls. (lu.se)
  • Divisible Microplate: Consisting of 12 modules of 8 wells, highly purified human cardiolipin is bound to microwells. (elisakits.co.uk)
  • In mammalian cells, but also in plant cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane, where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism. (wikipedia.org)
  • Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
  • Metabolism and function of mitochondrial cardiolipin. (elisakits.co.uk)
  • Some isoforms may be involved in cardiolipin metabolism. (lu.se)
  • For instance, cardiolipin, an anionic phospholipid, has been found to be associated to a number of eukaryotic and prokaryotic respiratory complexes. (pasteur.fr)
  • In this review, we describe current knowledge of the functions associated with cardiolipin binding to respiratory complexes in prokaryotes as a frame to discuss how specific lipid binding may tune their reactivity towards quinone and participate to supercomplex formation of both aerobic and anaerobic respiratory chains. (pasteur.fr)
  • Among these, the Cardiolipin is the most commonly used phospholipid as an antigen for determining the aPL by ELISA method. (diametra.com)
  • There is evidence to suggest that the cardiolipin net content of MOM is elevated during the process of apoptosis. (elisakits.co.uk)
  • The tafazzin protein is involved in altering a fat (lipid) called cardiolipin, which plays critical roles in the mitochondrial inner membrane. (medlineplus.gov)
  • Once altered by tafazzin, cardiolipin is key in maintaining mitochondrial shape, energy production, and protein transport within cells. (medlineplus.gov)
  • Cardiolipin remodeling enables protein crowding in the inner mitochondrial membrane. (bvsalud.org)
  • Of note, investigating further the effects of cardiolipin deficiency or modification (oxidation/saturation) in the adaptive immune response is pivotal in the context of current (Tazpower) or future trials impacting cardiolipin remodeling and/or oxidation. (barthsyndrome.org)
  • We utilized three types of biological tissues and oxidative insults, namely rotenone treatment of lymphocytes to induce mitochondrial damage and cell death, pulmonary inhalation exposure to single walled carbon nanotube s, as well as total body irradiation, in order to identify cardiolipin oxidation products, critical to the cell damage/cell death pathways in these tissues following cellular stress/injury. (cdc.gov)
  • Our results indicate that selective cardiolipin (CL) oxidation is a result of a non-random free radical process. (cdc.gov)
  • Whether this might be mediated by the reduction or loss of cardiolipin or the accumulation of specific cardiolipin species, how this could happen and whether this could exacerbate or worsen muscle condition in Barth syndrome patients will be the core of this project. (barthsyndrome.org)
  • Moreover, polar and septal accumulation of cardiolipin in a number of prokaryotes may ensure proper spatial segregation and/or activity of proteins. (pasteur.fr)
  • First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. (elisakits.co.uk)
  • As there are four distinct alkyl chains in cardiolipin, the potential for complexity of this molecule species is enormous. (wikipedia.org)
  • However, in most animal tissues, cardiolipin contains 18-carbon fatty alkyl chains with 2 unsaturated bonds on each of them. (wikipedia.org)
  • Cardiolipin (IUPAC name 1,3-bis(sn-3'-phosphatidyl)-sn-glycerol, "sn" designating stereospecific numbering) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition. (wikipedia.org)
  • Cardiolipin bicyclic structure Structure of NAO NAO & CL arranged in a highly ordered way The detection, quantification, and localisation of CL species is a valuable tool to investigate mitochondrial dysfunction and the pathophysiological mechanisms underpinning several human disorders. (wikipedia.org)
  • Our findings indicate that oxidized species of not only cardiolipin, but other phospholipid species, can be effectively separated from their non-oxidized counterparts in this two dimensional system. (cdc.gov)
  • Bacteria thriving at extremely high pH tend to produce more cardiolipin (CL) as well as bis-mono-acyl-glycero-phosphate (BMP) 3 . (nature.com)
  • The role of decreased cardiolipin and impaired electron transport chai" by J. Tam, A. Hong et al. (hofstra.edu)
  • The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
  • Catabolism of cardiolipin may happen by the catalysis of phospholipase A2 (PLA) to remove fatty acyl groups. (wikipedia.org)
  • Autoantikörper gegen Cardiolipin sind auch ein immunologisches Klassifikationskriterium für den systemischen Lupus erythrematodes (SLE). (orgentec.com)
  • Defects in the adaptive branch of immunity might also further deteriorate muscle function if inflammation is modulated by cardiolipin deficiency. (barthsyndrome.org)
  • This compound belongs to the class of organic compounds known as cardiolipins. (drugbank.com)
  • Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. (ku.dk)
  • As a result, tafazzin cannot alter cardiolipin, and levels of functional cardiolipin are reduced. (medlineplus.gov)
  • A lack of functional cardiolipin and an excess of MLCL are thought to impair normal mitochondrial shape and functions. (medlineplus.gov)
  • ATRA reduces the amounts of cardiolipins and the effect is associated with the growth-inhibitory activity of the retinoid. (slub-dresden.de)
  • Down-regulation of cardiolipins is due to a reduction of mitochondria, which is caused by an ATRA-dependent decrease in the expression of nuclear genes encoding mitochondrial proteins. (slub-dresden.de)
  • See the Cardiolipin Cardiolipin IgA, G, M ELISA Kit product insert for specific details on preparation, procedures, quality control, and test result interpretation. (rapidtest.com)
  • How is a Cardiolipin IgM test performed? (medreach.in)
  • Our findings indicate that the Mic10 core machinery of MICOS is regulated by several mechanisms, including interaction with cardiolipin and antagonistic actions of Mic26 and Mic27. (rug.nl)
  • The name "cardiolipin" is derived from the fact that it was first found in animal hearts. (wikipedia.org)
  • A phospholipid, or type of fat found in the blood, is called cardiolipin. (ganeshdiagnostic.com)