Chemicals and Drugs
Cardiolipins
Cardiolipins
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.

Nitric-oxide-induced apoptosis in human leukemic lines requires mitochondrial lipid degradation and cytochrome C release. (1/1010)

We have previously shown that nitric oxide (NO) stimulates apoptosis in different human neoplastic lymphoid cell lines through activation of caspases not only via CD95/CD95L interaction, but also independently of such death receptors. Here we investigated mitochondria-dependent mechanisms of NO-induced apoptosis in Jurkat leukemic cells. NO donor glycerol trinitrate (at the concentration, which induces apoptotic cell death) caused (1) a significant decrease in the concentration of cardiolipin, a major mitochondrial lipid; (2) a downregulation in respiratory chain complex activities; (3) a release of the mitochondrial protein cytochrome c into the cytosol; and (4) an activation of caspase-9 and caspase-3. These changes were accompanied by an increase in the number of cells with low mitochondrial transmembrane potential and with a high level of reactive oxygen species production. Higher resistance of the CD95-resistant Jurkat subclone (APO-R) cells to NO-mediated apoptosis correlated with the absence of cytochrome c release and with less alterations in other mitochondrial parameters. An inhibitor of lipid peroxidation, trolox, significantly suppressed NO-mediated apoptosis in APO-S Jurkat cells, whereas bongkrekic acid (BA), which blocks mitochondrial permeability transition, provided only a moderate antiapoptotic effect. Transfection of Jurkat cells with bcl-2 led to a complete block of apoptosis due to the prevention of changes in mitochondrial functions. We suggest that the mitochondrial damage (in particular, cardiolipin degradation and cytochrome c release) induced by NO in human leukemia cells plays a crucial role in the subsequent activation of caspase and apoptosis.  (+info)

Enzymatic properties of vesicle-reconstituted human cytochrome P450SCC (CYP11A1) differences in functioning of the mitochondrial electron-transfer chain using human and bovine adrenodoxin and activation by cardiolipin. (2/1010)

The recently reported heterologous expression and purification of both human cytochrome P450SCC and adrenodoxin [Woods, S.T., Sadleir, J., Downs, T., Triantopoulos, T., Haedlam, M.J. & Tuckey, R.C. (1998) Arch. Biochem. Biophys. 353, 109-115] has enabled us to perform studies with the membrane-reconstituted human enzymes to better understand the side-chain cleavage reaction in humans. Human P450SCC was successfully reconstituted into dioleoylphosphatidylcholine vesicles with and without cardiolipin and its enzymatic properties characterized in the membrane-bound state. Enhancement of the P450SCC activity and significant activation by cardiolipin were observed when human adrenodoxin instead of bovine adrenodoxin was used as electron donor. In the absence of cardiolipin, Km for cholesterol was decreased twice in the case of human adrenodoxin indicating enhanced cholesterol binding. On the other hand, in the presence of cardiolipin in the membrane both Km and V for cholesterol were decreased with human adrenodoxin as electron donor. Kinetic analysis of the interaction between human P450SCC and its redox partners provided evidence for enhanced binding of the human electron donor to human P450SCC indicated by both an increased V and decreased Kd for human adrenodoxin compared with the values with bovine adrenodoxin. Because no similar effects were observed in Tween 20 micelles, these results suggest that the phospholipid membrane may play an important role in the interaction of human adrenodoxin with human P450SCC.  (+info)

Phospholipid composition of Rickettsia prowazeki grown in chicken embryo yolk sacs. (3/1010)

The phospholipid composition and phospholipid fatty acid composition of purified Rickettsia prowazeki were determined. The lipid phosphorous content was 6.8 +/- 1.3 microgram/mg of total rickettsial protein. The major phospholipid was phosphatidylethanolamine (60 to 70%); phosphatidylglycerol constituted 20%, and phosphatidylcholine constituted 15%. Small amounts of phosphatidylserine and cardiolipin were detected. The principal fatty acids were 18:1, 16:1, and 16:0. The fatty acid composition of the phosphatidylcholine in the rickettsial extracts was very different than that of the other rickettsial phosphatides and very similar to that of normal yolk sac phosphatidylcholine. The specific of the phosphatidylcholine of rickettsiae grown in the presence of 32P was markedly lower than that of phosphatidylethanolamine and phosphatidylglycerol. It is suggested that the phosphatidylcholine in the rickettsial extract is yolk sac derived and either tightly absorbed or exchanged into the rickettsial membrane.  (+info)

Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. (4/1010)

Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a 'cofactor', identified as beta 2-glycoprotein I (beta 2-GPI), to bind phospholipids. We show here that aCL can bind beta 2-GPI in the absence of phospholipid. Binding of aCL to beta 2-GPI is dependent upon the beta 2-GPI being immobilized on an appropriate surface including cardiolipin, irradiated polystyrene and nitrocellulose membrane. This effect cannot be explained by increased antigen density of beta 2-GPI immobilized on these surfaces. Rather, conformational changes that occur following the interaction of beta 2-GPI with phospholipid render this protein antigenic to aCL. Liquid-phase beta 2-GPI was not antigenic for aCL. Thus, aCL cannot bind circulating beta 2-GPI. These findings may explain why patients with aCL can remain healthy for many years but then undergo episodes of thrombosis or fetal loss without changes in their circulating aCL profile, as the triggering event for these pathologies can be predicted to be one that renders beta 2-GPI antigenic for aCL.  (+info)

Transbilayer movement and distribution of spin-labelled phospholipids in the inner mitochondrial membrane. (5/1010)

The transmembrane diffusion and equilibrium distribution of spin-labelled phosphatidylethanolamine (PE*), phosphatidylcholine (PC*) and cardiolipin (CL*) were investigated in purified mitochondrial inner membranes using electron spin resonance spectroscopy. Using the back exchange technique, we found that the outside-inside movement of PE* and PC* in beef-heart inner mitochondrial membranes was rapid (t1/2 in the range 10-15 min at 30 degrees C). The steady-state distributions in non-energised mitoplasts were approximately 30% in the inner leaflet for PC* and 39% for PE*. Within the limits of probe concentration that can possibly be used in these experiments, the initial velocity of the inward movement was not saturable with respect to the amount of analogue added to the membranes, suggesting that the spin-labelled phospholipids diffused passively between the two leaflets of the inner mitochondrial membrane. In energised mitoplasts, PC* behaviour was not affected, PE* diffused approximately two times faster toward the inner monolayer but reached the same plateau. Treatment of energised mitochondria with N-ethylmaleimide did not affect PC* diffusion, while the kinetics of PE* internalisation became identical to that of PC*. Similar results were found when PC* and PE* movements were studied in mitoplasts from beef heart, rat liver or yeast. The spin-labelled cardiolipin, which possesses four long chains, had to be introduced in the mitoplast with some ethanol. After equilibration (t1/2 of the order of 13 min at 30 degrees C), the transmembrane distribution suggested that approximately half of the cardiolipin analogue remained in the outer leaflet. These results do not allow us to determine if a specific protein (or flippase) is involved in the phospholipid transmembrane traffic within inner mitochondrial membranes, but they show that lipids can rapidly flip through the mitochondrial membrane.  (+info)

Involvement of Arg-328, Arg-334 and Arg-342 of DnaA protein in the functional interaction with acidic phospholipids. (6/1010)

We reported previously that three basic amino acids (Arg-360, Arg-364 and Lys-372) of DnaA protein are essential for its functional interaction with cardiolipin. In this study, we examined the effect of mutation of some basic amino acids in a potential amphipathic helix (from Lys-327 to Ile-345) of DnaA protein on this interaction. ATP binding to the mutant DnaA protein, in which Arg-328, Arg-334 and Arg-342 were changed to acidic amino acids, was less inhibited by cardiolipin than that of the wild-type protein, as was the case for mutant DnaA protein with mutations of Arg-360, Arg-364 and Lys-372. A mutant DnaA protein with mutations of all six basic amino acids showed the most resistance to the inhibition of ATP binding by cardiolipin. These results suggest that Arg-328, Arg-334 and Arg-342, like Arg-360, Arg-364 and Lys-372, are also involved in the functional interaction between DnaA protein and acidic phospholipids.  (+info)

Maternal cardiolipin, beta 2-glycoprotein-I and prothrombin antibody expression in high-risk pregnancies with bilateral abnormal uterine artery Doppler waveforms. (7/1010)

OBJECTIVE: To compare the frequency of maternal serum antiphospholipid antibodies (to cardiolipin, beta 2-glycoprotein I and prothrombin) in pregnancies presenting with bilateral abnormal uterine artery Doppler waveforms. DESIGN: Retrospective analysis of stored serum. SUBJECTS: Cases comprised 47 singleton pregnancies with bilateral abnormal uterine artery Doppler waveforms at 24 weeks of gestation, followed from 20 weeks, and controls were 100 healthy pregnancies with normal uterine artery Doppler waveforms. METHODS: Ultrasound examination utilized a 5-MHz curvilinear transabdominal transducer with pulsed and color Doppler facilities. Antiphospholipid antibodies were analyzed by ELISA methodology, and reference ranges were established using the geometric mean +/- 2 SD of healthy non-pregnant adults. Human chorionic gonadotropin (hCG) levels were obtained from patient notes. RESULTS: Anticardiolipin antibodies were detected in 11 (23%) of the cases (IgG, n = 7; IgM, n = 6) compared with ten (10%) of the controls (p < 0.05). Low titer anticardiolipin IgG (range, 5.5-35.3; median, 6.3 GPL units) and anticardiolipin IgM (range, 3.4-14.7; median, 5.3 MPL units) were detected in cases. Amongst the cases, adverse perinatal outcomes were more common in the presence of raised levels of anticardiolipin antibodies. Anti-beta 2-glycoprotein I IgG was not detected in any of the cases. Antiprothrombin IgG was not detected, but antiprothrombin IgM occurred in 10.6% of cases compared with 2% of controls. CONCLUSIONS: Women with persistent bilateral abnormal uterine artery. Doppler waveforms in mid-gestation were more likely to express raised levels of anticardiolipin antibodies than healthy controls with normal uteroplacental perfusion. Anticardiolipin antibodies without anti-beta 2-glycoprotein I binding may be involved in the pathogenesis of uteroplacental ischemia in a proportion of high-risk pregnancies.  (+info)

Polar lipids of four Listeria species containing L-lysylcardiolipin, a novel lipid structure, and other unique phospholipids. (8/1010)

The membrane lipids of Listeria innocua, Listeria monocytogenes, Listeria seeligeri and Listeria welshimeri were fractionated on DEAE-cellulose and purified by chromatography on silica gel and/or preparative TLC. The lipid structures were elucidated by chemical and chromatographic means. The polar lipid composition of the four listeria species was similar. Phospholipids predominated. They consisted of phosphatidylglycerol, L-lysylphosphatidylglycerol, cardiolipin [bis(phosphatidyl)glycerol] and L-lysylcardiolipin. A phospholipid more polar than cardiolipin, possibly two L-lysyl derivatives of it, sn-glycero-1-phosphoglycolipid, its D-alanyl derivative, and polyprenol phosphate were also detected. Towards the end of exponential growth, the relative amounts of cardiolipin and L-lysylcardiolipin increased, approaching 47-78% lipid phosphorus with a ratio of L-lysylcardiolipin to cardiolipin of 0.25-1.6. As shown by fast atom bombardment-mass spectrometry, cardiolipin and L-lysylcardiolipin consisted of five molecular species due to various fatty acid combinations. L-lysylcardiolipin has so far not been found in nature. It belongs to the recently discovered class of substituted cardiolipins. Its occurrence in the four listeria species tested shows that it is a characteristic lipid component of the L. monocytogenes line of descent. Further studies on the lipid pattern of members of the other descent line are required to decide whether lysylcardiolipin can serve as a genus-specific chemotaxonomic marker for listeriae.  (+info)

Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize...
Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis. Academic Article ...
http://vivo.med.cornell.edu/display/pubid84897388046
Human Metabolome Database: Showing metabocard for CL(18:2(9Z,12Z)/18:1(9Z)/18:1(9Z)/16:0) (HMDB0010234)Human Metabolome Database: Showing metabocard for CL(18:2(9Z,12Z)/18:1(9Z)/18:1(9Z)/16:0) (HMDB0010234)
CL(18:2(9Z,12Z)/18:1(9Z)/18:1(9Z)/16:0) is a cardiolipin (CL). Cardiolipins are sometimes called double phospholipids because they have four fatty acid tails, instead of the usual two. They are glycerophospholipids in which the O1 and O3 oxygen atoms of the central glycerol moiety are each linked to one 1,3-diacylglyerol chain. Their general formula is OC(COP(O)(=O)OC[[email protected]@H](CO[R1])O[R2])COP(O)(=O)OC[[email protected]@H](CO[R3])O[R4], where R1-R4 are four fatty acyl chains. CL(18:2(9Z,12Z)/18:1(9Z)/18:1(9Z)/16:0) contains one chain of (9Z,12Z-octadecadienoyl) at the C1 position, two chains of (9Z-octadecenoyl) at the C2 and C3 positions, one chain of hexadecanoic acid at the C4 position fatty acids. Cardiolipins are known to be present in all mammalian cells, especially cells with a high number of mitochondria. De novo synthesis of Cardiolipins begins with condensing phosphatidic acid (PA) with cytidine-5-triphosphate (CTP) to form cytidine-diphosphate-1,2-diacyl-sn-glycerol (CDP-DG). Glycerol-3-phosphate is ...
https://hmdb.ca/metabolites/HMDB0010234
Human Metabolome Database: Showing metabocard for CL(i-12:0/i-24:0/i-15:0/i-21:0) (HMDB0089312)Human Metabolome Database: Showing metabocard for CL(i-12:0/i-24:0/i-15:0/i-21:0) (HMDB0089312)
CL(i-12:0/i-24:0/i-15:0/i-21:0) is a cardiolipin (CL). Cardiolipins are sometimes called double phospholipids because they have four fatty acid tails, instead of the usual two. They are glycerophospholipids in which the O1 and O3 oxygen atoms of the central glycerol moiety are each linked to one 1,3-diacylglyerol chain. Their general formula is OC(COP(O)(=O)OC[[email protected]@H](CO[R1])O[R2])COP(O)(=O)OC[[email protected]@H](CO[R3])O[R4], where R1-R4 are four fatty acyl chains. CL(i-12:0/i-24:0/i-15:0/i-21:0) contains one chain of 10-methylundecanoic acid at the C1 position, one chain of 22-methyltricosanoic acid at the C2 position, one chain of 13-methyltetradecanoic acid at the C3 position, one chain of 19-methyleicosanoic acid at the C4 position fatty acids. Cardiolipins are known to be present in all mammalian cells, especially cells with a high number of mitochondria. De novo synthesis of Cardiolipins begins with condensing phosphatidic acid (PA) with cytidine-5-triphosphate (CTP) to form ...
https://hmdb.ca/metabolites/HMDB0089312
Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation<...
TY - JOUR. T1 - Lysocardiolipin acyltransferase regulates TGF-β mediated lung fibroblast differentiation. AU - Huang, Long Shuang. AU - Jiang, Peiyue. AU - Feghali-Bostwick, Carol. AU - Reddy, Sekhar P.. AU - Garcia, Joe G.N.. AU - Natarajan, Viswanathan. PY - 2017/11. Y1 - 2017/11. N2 - Lysocardiolipin acyltransferase (LYCAT), a cardiolipin remodeling enzyme, plays a key role in mitochondrial function and vascular development. We previously reported that reduced LYCAT mRNA levels in peripheral blood mononuclear cells correlated with poor pulmonary function outcomes and decreased survival in IPF patients. Further LYCAT overexpression reduced lung fibrosis, and LYCAT knockdown accentuated experimental pulmonary fibrosis. NADPH Oxidase 4 (NOX4) expression and oxidative stress are known to contribute to lung fibroblast differentiation and progression of fibrosis. In this study, we investigated the role of LYCAT in TGF-β mediated differentiation of human lung fibroblasts to myofibroblasts, and ...
https://arizona.pure.elsevier.com/en/publications/lysocardiolipin-acyltransferase-regulates-tgf-%CE%B2-mediated-lung-fib
Glycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-AldrichGlycerophosphoglycerophosphoglycerols (Cardiolipins) - Glycerophospholipids | Sigma-Aldrich
Cardiolipin is found predominantly in the membranes of mitochondria and bacteria. It is a unique diphosphatidylglycerol containing four acyl groups. In animal tissues 80% of the acyl groups are composed of linoleic acid (18:2(n-6)).The identification of Barth′s syndrome, a disease associated with abnormalities in the fatty acid composition of cardiolipin causing cardiomyopathy and neutropenia, has displayed the importance of cardiolipin in mitochondrial functionality. Cardiolipin effects mitochondrial bioenergetics by providing essential structural and functional support to proteins localized within the mitochondria. Specifically, interaction of cardiolipin with cytochrome oxidase and adenine nucleotide translocase is required in order for both of these mitochondrial enzymes to maintain activity.Cardiolipin has been shown to perform a role in a number of other specific biological activities, including oxidative phosphorylation, apoptosis, cholesterol translocation and gene
https://www.sigmaaldrich.com/life-science/biochemicals/biochemical-products.html?TablePage=15845151
CL(14:0/14:0/18:1(11Z)/22:0) (YMDB06665) - Yeast Metabolome Database
CL(14:0/14:0/18:1(11Z)/22:0) is a cardiolipin (CL). Cardiolipins are sometimes called a double phospholipid because they have four fatty acid tails, instead of the usual two. CL(14:0/14:0/18:1(11Z)/22:0) contains two chains of tetradecanoic acid at the C1 and C2 positions, one chain of (11Z-octadecenoyl) at the C3 position, one chain of docosanoic acid at the C4 position. While the theoretical charge of cardiolipins is -2, under normal physiological conditions (pH near 7), the molecule may carry only one negative charge. In prokaryotes such as E. coli, the enzyme known as diphosphatidylglycerol synthase catalyses the transfer of the phosphatidyl moiety of one phosphatidylglycerol to the free 3-hydroxyl group of another, with the elimination of one molecule of glycerol. In E. coli, which acylates its glycerophospholipids with acyl chains ranging in length from 12 to 18 carbons and possibly containing an unsaturation, or a cyclopropane group more than 100 possible CL molecular species are ...
http://www.ymdb.ca/compounds/YMDB06665
If you have trouble with Recurrent Pregnancy Loss - Turkey ivfIf you have trouble with Recurrent Pregnancy Loss - Turkey ivf
Genetic analysis (chromosome/ Karyotype analysis): Blood samples should be taken from man and woman and tested for some probable abnormalities in the chromosomes, (missing chromosomes or additions to each chromosome, and translocations of chromosomes (in which all chromosomes are present but in different locations).. Anti Phospholipid Antibodies (APA) - cardiolipins are proteins found in many cells in your body. They help regulate blood flow throughout the body. However, when your body looks at the cardiolipins as an enemy or invader, it will attack them by creating antibodies . The three main groups anticardiolipins are: IgG, IgM, IgA.. Anti Cardiolipin Antibodies (ACA)- cells that attack the nuclei of other cells in your body. This is a mistake made by the body, thinking the good guys are the bad guys. Low levels should cause no problems.. Anti Nuclear Antibodies (ANA)- Again this is your body mistaking the good for the bad. Only this time it attacks the nuclei of the cell(s).. Lupus Anti ...
http://www.ivfpregnancy.org/ivf-news/320-if-you-have-trouble-with-recurrent-pregnancy-loss.html
Lysocardiolipin acyltransferase 1Lysocardiolipin acyltransferase 1
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages ...
https://pharos.nih.gov/idg/targets/Q6UWP7
Membrane Lipid-Producing Archaeal Enzyme Is PromiscuousMembrane Lipid-Producing Archaeal Enzyme Is Promiscuous
Cardolipins are a separate class of phospholipids present in the cell membranes of organisms from all domains of life. In studying the enzyme that is responsible for producing cardiolipins in archaea biochemists discovered a single archaeal enzyme can produce a range of natural and non-natural cardiolipins, as well as other phospholipids.
https://www.technologynetworks.com/cell-science/news/membrane-lipid-producing-archaeal-enzyme-is-promiscuous-348533
Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid | Journal of Experimental &...Role of mitochondria and cardiolipins in growth inhibition of breast cancer cells by retinoic acid | Journal of Experimental &...
All-trans-retinoic-acid (ATRA) is a promising agent in the prevention/treatment of breast-cancer. There is growing evidence that reprogramming of cellular lipid metabolism contributes to malignant transformation and progression. Lipid metabolism is implicated in cell differentiation and metastatic colonization and it is involved in the mechanisms of sensitivity/resistance to different anti-tumor agents. The role played by lipids in the anti-tumor activity of ATRA has never been studied. We used 16 breast cancer cell-lines whose degree of sensitivity to the anti-proliferative action of ATRA is known. We implemented a non-oriented mass-spectrometry based approach to define the lipidomic profiles of each cell-line grown under basal conditions and following treatment with ATRA. To complement the lipidomic data, untreated and retinoid treated cell-lines were also subjected to RNA-sequencing to define the perturbations afforded by ATRA on the whole-genome gene-expression profiles. The number and functional
https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1438-y
Biology Seminar - Mitochondrial Cardiolipin As A Mediator Of Cell Death Evasion In Highly Glycolytic Cancer - Events | Calvin...Biology Seminar - Mitochondrial Cardiolipin As A Mediator Of Cell Death Evasion In Highly Glycolytic Cancer - Events | Calvin...
Kristin Dittenhafer-Reed, PhD, Van Andel Institute Researcher in the MacKeigan Laboratory that focuses on identifying and understanding the genes and signaling pathways that, when mutated, contribute to the pathophysiology of cancer and neurodegeneration.. Altered cellular metabolism and the evasion of cell death are two hallmarks of cancer. Both of these hallmarks involve the mitochondria, the metabolic centers of the cell and critical players in initiating apoptosis. This seminar will highlight studies of a specific mitochondrial membrane component, cardiolipin, which may serve as a molecular bridge connecting altered metabolism and resistance to cell death. Cardiolipin is required for proper mitochondrial structure and function, and importantly, it facilitates the cellular events that initiate apoptosis. Cancer cells are able to limit or evade apoptosis, often allowing cells to resist chemotherapy and causing a significant clinical problem. Using cellular biology and quantitative biochemistry ...
https://calvin.edu/calendar/event.html?id=d18eced3-ee2a-451e-86aa-39d163c428d7
Role of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity | Microbiology SocietyRole of anionic phospholipids in the adaptation of Bacillus subtilis to high salinity | Microbiology Society
The importance of the content of anionic phospholipids [cardiolipin (CL) and phosphatidylglycerol (PG)] in the osmotic adaptation and in the membrane structure of Bacillus subtilis cultures was investigated. Insertion mutations in the three putative cardiolipin synthase genes (ywiE, ywnE and ywjE) were obtained. Only the ywnE mutation resulted in a complete deficiency in cardiolipin and thus corresponds to a true clsA gene. The osmotolerance of a clsA mutant was impaired: although at NaCl concentrations lower than 1·2 M the growth curves were similar to those of its wild-type control, at 1·5 M NaCl (LBN medium) the lag period increased and the maximal optical density reached was lower. The membrane of the clsA mutant strain showed an increased PG content, at both exponential and stationary phase, but no trace of CL in either LB or LBN medium. As well as the deficiency in CL synthesis, the clsA mutant showed other differences in lipid and fatty acids content compared to the wild-type, suggesting a
https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.28345-0
1-MLCL(0:0/16:0/16:0/16:0) (YMDB11607) - Yeast Metabolome Database
1-MLCL(0:0/16:0/16:0/16:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails, instead of the usual two. 1-MLCL(0:0/16:0/16:0/16:0) contains one chain of at the C1 position, three chains of hexadecanoic acid at the C2, C3 and C4 positions. MLCL is present in eukaryotes as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from a cardiolipin results in generation of monolysocardiolipin (MLCL). MLCL has been used as an inter-mediate in the synthesis of spin-labeled CL to study the interaction of CL with mitochondrial enzymes. Because a role for MLCL has been suggested in apoptosis, this molecule has been used to study its interaction with various enzymes involved in lipid remodeling and apoptosis. There are two species of monolysocardiolipins, 1-MLCL which is missing a fatty acid in position R1 the and 2-MLCL which is missing a fatty acid in position R4 ...
http://www.ymdb.ca/compounds/YMDB11607?smpdb_pathways=10&smpdb_reactions=1322
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies | ScienceCardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies | Science
The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.. ...
http://science.sciencemag.org/content/308/5730/1906?ijkey=euBwaEabvb5Qg&keytype=ref&siteid=sci
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies | ScienceCardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies | Science
Fig. 2. Assay of mAbs 2F5 and 4E10 against lipids and specificity of 2F5 and 4E10 mAb binding to cardiolipin. Microtiter plates were coated with 0.2 to 10 μg of lipid, blocked with 3% phosphate-buffered saline (PBS)-bovine serum albumin (BSA), and mAbs were diluted in PBS-Tween 20 (0.05%) containing 3% BSA and 2% normal goat serum. (A) Enzyme-linked immunosorbent assay (ELISA) reactivity of mAbs 4E10 (solid bars) and 2F5 (open bars) to CL, PS, PC, PE, and SM. Whereas both 4E10 and 2F5 reacted with cardiolipin, only 4E10 reacted with the other lipids tested. The reactivity of control human anti-CCR5 binding site mAb 1.7b was negative (33). Both mAbs 4E10 and 2F5 bound directly to cardiolipin, because cardiolipin binding in ELISA did not require the presence of bovine serum as a source of β2 glycoprotein-1; as an additional negative control, the reactivity of mAbs against empty methanol-coated plates was negative for 2F5 and was seen only at concentrations of 4E10≥2.5 μg per milliliter (33). ...
https://science.sciencemag.org/content/308/5730/1906?ijkey=e07f88225234d3d7a1c3cf11f9f003c228f03db1&keytype2=tf_ipsecsha
Studies on cardiolipin III. Structural identity of ox-heart cardiolipin and synthetic diphosphatidyl glycerolStudies on cardiolipin III. Structural identity of ox-heart cardiolipin and synthetic diphosphatidyl glycerol
Chemical synthesis of diphosphatidyl glycerol, a long-chain fatty acid ester of diphosphatidyl glycerol, phosphatidyl diglyceride and phosphatidyl glycerophosphate has stimulated a structural comparison with natural cardiolipin. Although in certain properties the various polyglycerol phospholipids are quite similar, the results of enzymic hydrolyses with phospholipase A (EC 3.1.1.4), acylation studies, optical ... read more rotation measurements and chromatography of the intact phospholipids and deacylated products indicated that beef-heart cardiolipin has a diphosphatidyl glycerol structure. Conclusive evidence was obtained by means of the breakdown of the phospholipids with phospholipase C (EC 3.1.4.3). The enzyme was found to hydrolyse both natural and synthetic diphosphatidyl glycerol into 1,2-diglyceride and 1,3-glycerol diphosphate, phosphatidyl glycerophosphate being an intermediate hydrolysis product. show less ...
http://dspace.library.uu.nl/handle/1874/16895
Cardiolipin - definition of cardiolipin by The Free DictionaryCardiolipin - definition of cardiolipin by The Free Dictionary
Define cardiolipin. cardiolipin synonyms, cardiolipin pronunciation, cardiolipin translation, English dictionary definition of cardiolipin. n. A phospholipid usually obtained from beef heart, used in combination with phosphatidylcholine and cholesterol as an antigen to diagnose syphilis
https://www.thefreedictionary.com/cardiolipin
Canadian Longitudinal Study on Aging (CLSA) - Partnerships - CIHRCanadian Longitudinal Study on Aging (CLSA) - Partnerships - CIHR
CLSAs vision is that partners will enrich the CLSA research platform, promote and foster its development into a dynamic, rich, comprehensive and unique resource for aging research. This premium resource will result in beneficial rewards for the partners through facilitating rapid adoption of sound research into health practice, programs, policies, services and products that will contribute to healthy aging and enhanced quality of life for older adults. The CLSA has been successful in additional fundraising with a variety of partners to support the implementation and baseline data collection phase of the CLSA (2010-2015). The CLSA continues to develop partnerships for the first (2015-2018) and second (2018-2021) follow-ups to support and sustain the long-term vision of the CLSA. A full list of CLSA partnerships is available on the Partners section of the CLSA website.. ...
https://cihr-irsc.gc.ca/e/51057.html
Research Interests
Another focus of our research on cytochrome c is the proteins interaction with anionic cardiolipin containing liposomes by CD, absorption and resonance Raman spectroscopy. The specific aim of this project is to fully characterize structure and energy landscape of oxidized and reduced cytochrome c after the binding to the surface of such liposomes and after dissociation form the surface. These liposome serve as a model for the innermembrane of mitochondria. This will lead us to understand why the protein gains peroxidase activity on membrane surface if challenged with hydrogen peroxide. A detailed study aimed at exploring the binding and subsequent conformational changes of ferricytochrome c to cardiolipin containing liposomes have revealed two protein binding sites. For liposomes with 20% cardiolipin binding via site 1 is insensitive to the addition of NaCl and mostly preserves the native state, including the Fe-M80 linkage. Binding via site 2, however, causes a conformational transition into a ...
http://www.pages.drexel.edu/~rs344/Biospectroscopy_Research_Group/Research_Interests.html
About the CLSA Research Platform | Canadian Longitudinal Study on Aging
The Canadian Longitudinal Study on Aging (CLSA) is a large, national, long-term study of more than 50,000 individuals who were between the ages of 45 and 85 when recruited. These participants will be followed until 2033 or death. The aim of the CLSA is to find ways to help us live long and live well, and understand why some people age in healthy fashion while others do not.. Between 2010 and 2015, the CLSA recruited and collected information from more than 50,000 individuals. Now the study has entered its next phase where each individual recruited between 2010 and 2015 (baseline) will be re-contacted for the first follow-up. The first follow-up will be conducted between 2015 and 2018. During this phase, the CLSA research team will collect the same type of information that was collected at baseline, along with several new measures that have been introduced.. The CLSA is a longitudinal design, meaning that it will follow people over a long period of time. However, researchers will not wait years ...
https://clsa-elcv.ca/about-us/about-clsa-research-platform
High‐affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter | EMBO Reports
The mitochondrial calcium uniporter is a Ca2+‐activated Ca2+ channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca2+ signals. It is regulated by two paralogous EF‐hand proteins-MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate that both MICU1 and MICU2 are stabilized by Ca2+. We reconstitute the MICU1-MICU2 heterodimer and demonstrate that it binds Ca2+ cooperatively with high affinity. We discover that both MICU1 and MICU2 exhibit affinity for the mitochondria‐specific lipid cardiolipin. We determine the minimum Ca2+ concentration required for disinhibition of the uniporter in permeabilized cells and report a close match with the Ca2+‐binding affinity of MICU1-MICU2. We conclude that cooperative, high‐affinity interaction of the MICU1-MICU2 complex with Ca2+ serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca2+ signals. ...
http://embor.embopress.org/content/early/2017/06/14/embr.201643748
Mitochondrial lipids in neurodegeneration - pdf descargar
Mitochondrial lipids in neurodegeneration. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jul7/150078154118-Mitochondrial-lipids-in-neurodegeneration.php
On the Ornithinyl Ester of Phosphatidylglycerol of Mycobacterium 607 | Journal of BacteriologyOn the Ornithinyl Ester of Phosphatidylglycerol of Mycobacterium 607 | Journal of Bacteriology
Ornithinyl ester of phosphatidyl glycerol was found to accumulate in Mycobacterium 607 under acidic conditions (pH 5.6) of growth or in cultures of ultraviolet-irradiated (320 to 420 nm) bacilli. There was a corresponding decrease in cardiolipin content of the organisms under these conditions. ...
https://jb.asm.org/content/101/2/654?ijkey=cecad53e5bbb6afc309289d6d022b947fb8f0b67&keytype2=tf_ipsecsha
Discovery of Molecule That Makes Pneumonia Worse Could Lead to Ways of Treating InfectionDiscovery of Molecule That Makes Pneumonia Worse Could Lead to Ways of Treating Infection
Despite decades of research, there has been little new information on what biological mechanisms make bacterial pneumonia get worse, said senior author Rama K. Mallampalli, MD, a professor in the Acute Lung Injury Center of Excellence, University of Pittsburgh School of Medicine, and pulmonary division chief at the VA Pittsburgh Healthcare System.. Our study reveals some of the molecular steps that can lead to lung injury after infection and shows us new avenues for pneumonia therapy that dont have to target bacteria, as antibiotics do, Mallampalli says.. The researchers found that lung fluid from humans and mice with pneumonia contains abnormally high levels of cardiolipin, a structural molecule that is typically found in the membranes of energy-making mitochondria. A carrier protein called Atp8b1 transports the molecule from the lung fluid into the cell, acting as a pump that regulates cardiolipin levels.. Infection leads to the death of cells, and that releases cellular components, ...
https://www.infectioncontroltoday.com/view/discovery-molecule-makes-pneumonia-worse-could-lead-ways-treating-infection
clsa: Words Containing clsa
clsa: acls, acsl, alcs, alsc, ascl, aslc, cals, casl, clas, clsa, csal, csla, lacs, lasc, lcas, lcsa, lsac, lsca, sacl, salc, scal, scla, slac, slca, consolidate, clasp, declass, cleanse, clash, channel-surf, places, loquaciousness, class, accomplish, calories, classify, scrawl, facilities, collapse, scaffold, discombobulate, muscular, self-contained, altruistic, secular, ultramasculine, disconsolate, circumstantial, close-grained, consolidated, calaboose, claus, classic, classical, classy, mucilaginous, materialistic, clear-sighted, ceaseless, accomplished, acidulous, consultancy, consultative, calamitous, consolatory, chargeless, companionless, calescent, scantily, scarcely, callous, clangorous, convalescent, casual, crestfallen, collapsing, emasculate, musical, lackadaisical, formalistic, consultant, carelessness, ecclesiastic, ecclesiarch, disclaimer, cleansing, eschewal, disgracefulness, transatlantic, scholar, scholastic, scholasticism, accessibility, accomplishment, accomplishments, ...
http://2s2.info/clsa.html
Governance | Canadian Longitudinal Study on Aging
The Knowledge Translation and Communications Committee (KTCC) is the primary body responsible for initiating and facilitating knowledge translation and communications activities that support the objectives of the CLSA. It is a standing sub-committee of the CLSA Operations Committee, which provides recommendations to the CLSA Scientific Management Team.. The KTCC is composed of five voting members who are appointed by the CLSA Operations Committee (OC) for a term of two years.. The composition will include individuals, both internal and external to the CLSA, with knowledge translation expertise as well as representatives of key target audiences such as researchers, health-care providers and policy-makers. The KTCC will include at least one member of the OC.. The committee is supported by the CLSA communications officer who, as a non-voting member, will assist in coordinating the activities of the committee and maintaining documentation in collaboration with the chair. The committee will also ...
https://www.clsa-elcv.ca/about-us/governance
PRELID3A - PRELI domain containing protein 3A - Homo sapiens (Human) - PRELID3A gene & proteinPRELID3A - PRELI domain containing protein 3A - Homo sapiens (Human) - PRELID3A gene & protein
In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane.
https://www.uniprot.org/uniprot/Q96N28
Role of cardiolipin alterations in mitochondrial dysfunction and diseaseRole of cardiolipin alterations in mitochondrial dysfunction and disease
Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane where it is required for optimal mitochondrial function. In addition to its role in maintaining membrane potential and architecture, CL is known to provide essential structural and functional …
https://pubmed.ncbi.nlm.nih.gov/16899548/?dopt=Abstract
Maltaner Cardiolipin Antigen (cardiolipin Wasserman antigen) - TCS BiosciencesMaltaner Cardiolipin Antigen (cardiolipin Wasserman antigen) - TCS Biosciences
Manufacture and distribution of animal blood products, plasma, serum, microbiological diagnostic kits and quality control products, Buckinghamshire, UK
https://www.tcsbiosciences.co.uk/catalog/product_detail.php?CI_ID=4149
DI-fusion Holdings: Saturation of acyl chains converts cardiolipin from...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/289130/Holdings
Tafazzin - WikipediaTafazzin - Wikipedia
Tafazzin is a protein that in humans is encoded by the TAZ gene. Tafazzin is highly expressed in cardiac and skeletal muscle. It is involved in the metabolism of cardiolipin. Tafazzin functions as a phospholipid-lysophospholipid transacylase. The mutation of the tafazzin gene is associated with a number of clinical disorders including Barth syndrome (BTHS) (type II 3-Methylglutaconic aciduria), dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Tafazzin is responsible for remodeling of a phospholipid cardiolipin (CL), the signature lipid of the mitochondrial inner membrane. As a result, BTHS patients exhibit defects in CL metabolism, including aberrant CL fatty acyl composition, accumulation of monolysocardiolipin (MLCL) and reduced total CL levels. The protein was identified by Italian scientists Silvia Bione et al. in 1996. Owing to the complex procedure required for the identification of tafazzin, the protein was named after ...
https://en.wikipedia.org/wiki/Tafazzin
TafazzinTafazzin
Quantitative and qualitative alterations of mitochondrial cardiolipin have been implicated in the pathogenesis of Barth syndrome, an X-linked cardioskeletal myopathy caused by a deficiency in tafazzin, an enzyme in the cardiolipin remodeling pathway. A tafazzin-deficient Drosophila model of Barth syndrome that is characterized by low cardiolipin (CL) concentration, abnormal cardiolipin fatty acyl composition, abnormal mitochondria, and poor motor function has been generated earlier. This study shows that tafazzin deficiency in Drosophila disrupts the final stage of spermatogenesis, spermatid individualization, and causes male sterility. This phenotype can be genetically suppressed by inactivation of the gene encoding a calcium-independent phospholipase A2, iPLA2-VIA, which also prevents cardiolipin depletion/monolysocardiolipin accumulation, although in wild-type flies inactivation of the iPLA2-VIA does not affect the molecular composition of cardiolipin. Furthermore, it was shown that treatment ...
https://www.sdbonline.org/sites/FLY/genebrief/tafazzin.htm
Barth Syndrome Foundation : Barth Syndrome : What is Barth Syndrome?Barth Syndrome Foundation : Barth Syndrome : What is Barth Syndrome?
Barth syndrome (BTHS) is an X-linked genetic condition, usually transmitted from mother to son (although there is a relatively high incidence of new mutations in Barth syndrome and one confirmed case report of a female Barth syndrome patient). A mother who is a carrier of a Barth syndrome mutation (the gene is named tafazzin - also called TAZ or G4.5) shows no signs or symptoms of this disorder herself, probably due to skewed X-chromosome inactivation.. There is a 50% chance that a boy born to a female carrier will have Barth syndrome, whereas girls born to a carrier have a 50% risk of being carriers themselves. All daughters of a male with Barth syndrome will be carriers, however no sons will be affected. Because there are proven non-carrier mothers, all mothers of Barth syndrome children should be tested in order to define the genetic risk in each family.. Any male child related through the female line to a Barth syndrome individual should be tested for the disorder, as there can be great ...
https://www.barthsyndrome.org/barthsyndrome/whatisbarthsyndrome.html
LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry...LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry...
Lipids are ubiquitous and serve numerous biological functions; thus lipids have been shown to have great potential as candidates for elucidating biomarkers and pathway perturbations associated with disease. Methods expanding coverage of the lipidome increase the likelihood of biomarker discovery and could lead to more comprehensive understanding of disease etiology. We introduce LipidMatch, an R-based tool for lipid identification for liquid chromatography tandem mass spectrometry workflows. LipidMatch currently has over 250,000 lipid species spanning 56 lipid types contained in in silico fragmentation libraries. Unique fragmentation libraries, compared to other open source software, include oxidized lipids, bile acids, sphingosines, and previously uncharacterized adducts, including ammoniated cardiolipins. LipidMatch uses rule-based identification. For each lipid type, the user can select which fragments must be observed for identification. Rule-based identification allows for correct annotation of
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-017-1744-3
Inhibitory effects of anticardiolipin antibodies on lymphocyte proliferation and neutrophil phagocytosis. | Annals of the...Inhibitory effects of anticardiolipin antibodies on lymphocyte proliferation and neutrophil phagocytosis. | Annals of the...
Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles were studied for their effects on lymphocytes and neutrophils. At a concentration of 160 micrograms/ml they markedly suppressed the [3H]thymidine incorporation of mononuclear cells stimulated by phytohaemagglutinin (4.9 (SEM 1.9%) of the control) and pokeweed mitogen (26.7 (10.5%) of the control). In addition, anticardiolipin antibodies changed the cell cycle of phytohaemagglutinin stimulated lymphocytes such that the S and G2+M phases were significantly diminished (G0/G1 = 64.62%, S = 20.59%, G2+M = 14.78% in the presence of normal human IgG v G0/G1 = 86.07%, S = 10.32%, G2+M = 3.59% in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was shown not to be caused by an alteration of T cell subpopulations. However, the interleukin 2 receptors on the cell surface and the soluble interleukin 2 receptors in ...
http://ard.bmj.com/content/50/12/903
Inhibition of cardiolipin synthesis following infection with herpes simplex virus. - Semantic ScholarInhibition of cardiolipin synthesis following infection with herpes simplex virus. - Semantic Scholar
The results of this study show that the synthesis of the inner mitochondrial membrane phospholipid, cardiolipin, is markedly inhibited following infection of human embryonic lung or hamster embryo fibroblast cells with herpes simplex virus type 1 or 2. The synthesis of other phospholipids, i.e., phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, and phosphatidylinositol, is relatively unaffected.
https://www.semanticscholar.org/paper/Inhibition-of-cardiolipin-synthesis-following-infe-Tucker-Steiner/32e81e029f5a6eeab805eff59825e35de1d1e05f
Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts | Heart and Circulatory...
Tafazzin knockdown causes hypertrophy of neonatal cardiac myocytes (34), and mutation of the tafazzin gene causes dilated cardiomyopathy in Barth syndrome (64). Our work with neonatal cardiac fibroblasts (NVFs) showed that tafazzin knockdown increased ROS production, activated MAPKs including p42/44 and p38, stimulated transcriptional and translational factors, which in turn activated cell cycle regulators, and increased DNA and protein synthesis. On the other hand, tafazzin knockdown also decreased intracellular ATP, activated AMPK, and halted the energy-consuming process (i.e., cell proliferation), ultimately resulting in multinucleation, hypertrophy, and enhanced collagen secretion.. Tafazzin plays an important role in de novo cardiolipin synthesis and remodeling in the mitochondria. Tafazzin knockdown leads to reduced cardiolipin, which is consistent with previous studies involving yeast (28), Drosophila (72), and human skin fibroblasts (68). To be consistent with what is reported in mice ...
http://ajpheart.physiology.org/content/305/9/H1332.long
Barth Syndrome Diagnostic Laboratory TestingBarth Syndrome Diagnostic Laboratory Testing
General Information. There are several laboratory tests that can be undertaken to confirm the diagnosis of Barth syndrome. Finding a tafazzin gene (TAZ, also called G4.5) mutation that clearly disables protein synthesis or function is the most definitive test for Xq28-linked Barth syndrome. In addition, the finding of a severely depressed level of tetralinoleoyl-cardiolipin [Schlame et al (2002)], [Vreken et al (2000)] in platelets, cultured cells, or muscle tissue appears to be specific for Barth syndrome caused by mutations in the tafazzin gene. However, because completion of these tests can take more time than desirable when a child has critical cardiac disease, other laboratory tests, as discussed below, in the appropriate clinical setting can be all but diagnostic of Barth syndrome. Although not all clinicians follow the regulations, it is important to recognize that diagnostic information that is given to a patient or patients family must be provided by a laboratory that has met that ...
https://www.barthsyndrome.org/barthsyndrome/diagnose/diagnosticlaboratorytesting.html
Experimental and modeled chlorine solubilities in aluminosilicate melts at 1 to 7000 bars and 700 to 1250 °C: Applications to...Experimental and modeled chlorine solubilities in aluminosilicate melts at 1 to 7000 bars and 700 to 1250 °C: Applications to...
Hydrothermal experiments were conducted at ca. 1 to 7000 bars and 700 to 1250 °C in 121 rhyolitic to basaltic systems to determine Cl solubility in silicate melts, i.e., the maximum Cl concentration in melts that are saturated in a hydrosaline liquid with or without an aqueous or aqueous-carbonic vapor. The Cl concentration of melts increases with the Cl contents of the fluid unless the melt coexists with vapor plus hydrosaline liquid at fixed pressure and temperature; this phase assemblage buffers the Cl content of each phase with increasing Cl in the system. The Cl content of fluid(s)-saturated melts is independent of the CO2 concentration of the saline liquid ± vapor with up to 21 wt% CO2 in the fluid(s). The experiments show that Cl dissolution in aluminosilicate melts increases with temperature and pressure. Chlorine solubility is also a function of melt composition; it increases with the molar ([Al1/2+Ca1/2+Mg1/2+Na]/Si) of the melt.. These experimental data have been integrated with ...
https://pubs.geoscienceworld.org/msa/ammin/article-abstract/100/2-3/522/40399/experimental-and-modeled-chlorine-solubilities-in?redirectedFrom=fulltext
Cardiolipin synthase (CMP-forming)Cardiolipin synthase (CMP-forming)
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions ...
https://pharos.nih.gov/idg/targets/Q9UJA2
The role of structural lipids for proton translocation of respiratory complexes - Transport across and into membranes
Translocation of ions across biological membranes is an essential process of life. It is enabled by membrane proteins and relies on tight integration of these proteins into the lipid bilayer. The tight seal is the prerequisite for the generation of electrochemical proton gradients which are the key to biological energy conversion. It is now generally accepted that specific interactions between individual lipids and proteins are crucial for function and structural integrity of membrane proteins [1,2]. Of special interest is cardiolipin (CL), the signature lipid of mitochondria. CL is essential for the function of respiratory complex III and other mitochondrial membrane proteins and also for the integrity of respiratory supercomplexes. Yet, the molecular mechanisms and underlying structure-function relationships are not understood. Disruption of CL biosynthesis leads to the Barth syndrome. This cardio-skeletal myopathy is caused by mutations in the gene of the acyl transferase tafazzin resulting ...
http://www.taim.uni-freiburg.de/research/research-projects/P7
Summer 2015: Barth SyndromeSummer 2015: Barth Syndrome
After obtaining a skin sample from a patient with Barth syndrome, Pu was able to make stem cells from the patients skin cells, which he then turned into heart muscle cells. What was once skin became a beating heart muscle.. Next, Pu worked with Kevin Kit Parkers bioengineering group at the Wyss Institute for Biologically Inspired Engineering to assemble the muscle cells on a tiny, flexible plastic film that instructs the cells to line up and form organized muscle fibers. When the cells are assembled into this heart-on-a-chip format, they are able to work together so their beating bends the plastic film. The amount of force the patients heart muscle generates can be measured by how much the sheet bends with each beat. Comparing a Barth syndrome patients sheet with one from a patient with a normally functioning heart further revealed that the Barth heart muscle cells were very weak compared to normal heart muscle cells. Thus, combining the stem cell and heart-on-a-chip technologies allowed ...
https://heartmurmurs.childrenshospital.org/research/summer-2015-barth-syndrome/
Barth Syndrome Uk - Rare Disease UK
Barth syndrome is a rare genetic condition that mostly affects boys. Main symptoms:Heart muscle weakness (cardiomyopathy)Neutropenia (lack of white blood cells needed to fight bacterial infections).Fatigue and general muscle weakness. Growth/feeding issues Barth Syndrome UK is a well-established ...
https://www.raredisease.org.uk/member/barth-syndrome-uk/
Mitochondrial lipids of eld ascites tumor cells. Abstr. by C E. Park and C E. WennerMitochondrial lipids of eld ascites tumor cells. Abstr. by C E. Park and C E. Wenner
Park, C E. and Wenner, C E., Mitochondrial lipids of eld ascites tumor cells. Abstr. (1968). Subject Strain Bibliography 1968. 223 ...
https://mouseion.jax.org/ssbb1968/223/
AccessGUDID - DEVICE: ANTI-CARDIOLIPIN IgA (04260157080133)AccessGUDID - DEVICE: ANTI-CARDIOLIPIN IgA (04260157080133)
AccessGUDID - ANTI-CARDIOLIPIN IgA (04260157080133)- Anti-Cardiolipin Screen is an ELISA test system for the quantitative measurement of IgA class autoantibodies against cardiolipin in human serum or plasma. This product is intended for professional in vitro diagnostic use only.
https://accessgudid.nlm.nih.gov/devices/04260157080133
DSpace at EWHA: 혈액투석 환자에서 항 인지질 항체(항 cardiolipin 항체, 루푸스 항응고인자)가 동정맥루 폐쇄에 미치는 영향에 관한 임상적 연구DSpace at EWHA: 혈액투석 환자에서 항 인지질 항체(항 cardiolipin 항체, 루푸스 항응고인자)가 동정맥루 폐쇄에 미치는 영향에 관한 임상적 연구
혈액투석 환자에서 혈전형성에 의한 동정맥루 폐쇄 (vascualr access occlusion)는 가장 흔한 합병증 중의 하나로 혈관 수술 기술의 발전, 동맥경화증의 치료 및 항 혈소판 제제 사용을 포함한 약물적 치료에도 불구하고 혈액투석 환자 중 입원일수의 5-50% 정도를 차지하는 것으로 되어 있다. Anticardiolipin Antibody(ACA) 와 lupus anticoagulant(LA)는 항 인지질 항체들로 혈관 폐쇄 및 반복적인 유산의 중요한 위험인자로 알려져 있으나 혈액투석 치료를 받는 환자에서의 정확한 양성율 및 동정맥루 폐쇄와의 상관관계에 관해서는 아직 많은 이견이 있는 상태이다. 이에 저자는 이화여자대학교 부속병원에서 유지 혈액투석 중인 환자 50명, 총 68예의 동정맥루 (52 AV fistula, 16 AV grafts)를 대상으로 항 cardiolipin 항체와 루프스 항응고인자를 측정하고 병력 및 임상 기록 검토를 통해 이러한 ...
http://dspace.ewha.ac.kr/handle/2015.oak/187303
Phospholipid synthesis and exchange in isolated liver cells | Biochemical JournalPhospholipid synthesis and exchange in isolated liver cells | Biochemical Journal
1. The [32P]phosphate incorporated into the phospholipids of isolated rat hepatic cells is present in phosphatidic acid and to a smaller extent in phosphatidylinositol. 2. The ability to synthesize nitrogen-containing phospholipids is restored by adding a liver supernatant fraction, and it is suggested that the metabolic deficiency is caused by the leakage of cytoplasmic enzymes of the synthetase system from the cells. 3. Fortified cell preparations were pulse-labelled with [32P]phosphate, [Me-14C]choline, [2-14C]ethanolamine and [U-14C]inositol and the subsequent fate of the labelled microsomal and mitochondrial phospholipids followed. 4. A fall in the specific radioactivity of microsomal phospholipids and a rise in that of mitochondrial phospholipids is interpreted as providing evidence of a transfer of labelled phospholipid molecules from the synthetic site (endoplasmic reticulum) to the mitochondrial membranes in the intact cells. 5. The formation of the phospholipids of mitochondrial ...
http://www.biochemj.org/content/117/3/481
Cardiolipin ELISA kit | Autoimmune Disease kits | FDA-CE | 818-5913030 USA.Cardiolipin ELISA kit | Autoimmune Disease kits | FDA-CE | 818-5913030 USA.
Quality Cardiolipin ELISA kit from ELISA kits manufacturer and elisa kits supplier: Cardiolipin ELISA kit. Our kits are FDA, CE and ISO certified.
https://www.rapidtest.com/index.php?i=Blood-bank-ELISA-kits&id=13&cat=129
Cardiolipin ELISA kit |FDA-CE| 818 591 3030, USA.Cardiolipin ELISA kit |FDA-CE| 818 591 3030, USA.
Quality Cardiolipin ELISA kit from ELISA kits manufacturer and elisa kits suppliers: Cardiolipin IgG ELISA kit. Our kits are FDA-CE and ISO certified.
http://www.rapidtest.com/index.php?i=Autoimmune-Disease-kits&id=12&cat=8
The Fight Against Barth SyndromeThe Fight Against Barth Syndrome
A Perry, Florida mom is featured in this months edition of Readers Digest for promoting awareness of Barth Syndrome. Her son suffers from the disease that attacks young children.
http://www.wctv.tv/home/headlines/348266.html?site=full
BioVision launches-The First And The Best Cardiolipin Assay Kit In The Market - ePRNewsBioVision launches-The First And The Best Cardiolipin Assay Kit In The Market - ePRNews
MILPITAS, Calif. /ePRNews/ Cardiolipin is an important phospholipid present in the inner mitochondrial membrane and constitutes about 20% of its total lipid composition. It is essential for several mitochondrial functions such as electron…
https://eprnews.com/biovision-launches-the-first-and-the-best-cardiolipin-assay-kit-in-the-market-53577/
Farmer payouts to normalize Thailand: CLSAFarmer payouts to normalize Thailand: CLSA
Prinn Panitchpakdi, Country Head for Thailand at CLSA, discusses the armys decision to begin paying almost $5 billion worth of rice subsidies owed to Thai farmers.
https://www.cnbc.com/video/2014/05/25/farmer-payouts-to-normalize-thailand-clsa.html
Cardiolipin Antibody
This test helps your healthcare provider diagnose clotting disorders and autoimmune diseases. It measures the concentration of antibodies related to a fat molecule in your blood.
http://healthlibrary.lomalindahealth.org/Library/TestsProcedures/167,cardiolipin_antibody
Cardiolipin AntibodyCardiolipin Antibody
This test helps your healthcare provider diagnose clotting disorders and autoimmune diseases. It measures the concentration of antibodies related to a fat molecule in your blood.
http://healthlibrary.kansashealthsystem.com/RelatedItems/167,cardiolipin_antibody
25 Knot Winds Blast Off the Start of Les Voiles de St Barth 2011 - ALL AT SEA25 Knot Winds Blast Off the Start of Les Voiles de St Barth 2011 - ALL AT SEA
The first day of racing at the 2nd edition of Les Voiles de St. Barth dawned with 25 knots of tropical tradewind breeze and showers sweeping over the picturesque French island located midway down the Caribbean chain.
https://www.allatsea.net/25-knot-winds-blast-off-the-start-of-les-voiles-de-st-barth-2011/
Fighting a Rare Illness--TogetherFighting a Rare Illness--Together
The McCurdy Family (clockwise from left): Steve, Will, Kate, andEliza (photo courtesy of the McCurdy family) For more on the McCurdys and the Barth Syndrome Foundation, tune in to NBCs TODAY show onMonday, February 16. From the day he was born in 1986, Will McCurdy was a bright, engaging, and alert child. Butwhen he [...]
https://parade.com/36997/parade/fighting-a-rare-illnesstogether/
CardiolipinCardiolipin
... from a cow heart is used as an antigen in the Wassermann test for syphilis. Anti-cardiolipin antibodies can also be ... 2009;23(4):210-2. Cardiolipin at the US National Library of Medicine Medical Subject Headings (MeSH) Cardiolipin ( ... Phospholipase D (PLD) in the mitochondrion hydrolyses cardiolipin to phosphatidic acid. Because of cardiolipin's unique ... The enzyme can operate in reverse under some physiological conditions to remove cardiolipin. Catabolism of cardiolipin may ...
https://en.wikipedia.org/wiki/Cardiolipin
Anti-cardiolipin antibodiesAnti-cardiolipin antibodies
... (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In ... In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present individually or together; the two types of ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ...
https://en.wikipedia.org/wiki/Anti-cardiolipin_antibodies
LipidLipid
Cardiolipins are a subclass of glycerophospholipids containing four acyl chains and three glycerol groups that are particularly ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Hoch FL (March 1992). "Cardiolipins and biomembrane function" (PDF). Biochimica et Biophysica Acta (BBA) - Reviews on ...
https://en.wikipedia.org/wiki/Lipid
MitochondrionMitochondrion
Cardiolipin contains four fatty acids rather than two, and may help to make the inner membrane impermeable. Unlike the outer ... McMillin JB, Dowhan W (December 2002). "Cardiolipin and apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular and Cell ... Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin. This phospholipid was originally discovered ...
https://en.wikipedia.org/wiki/Mitochondrion
ATP synthaseATP synthase
It uses cardiolipin. The inhibitory IF1 also binds differently, in a way shared with trypanosomatida. Archaea do not generally ... Mühleip A, McComas SE, Amunts A (November 2019). "Structure of a mitochondrial ATP synthase with bound native cardiolipin". ...
https://en.wikipedia.org/wiki/ATP_synthase
ApoptosisApoptosis
A role for cardiolipin". The Journal of Biological Chemistry. 278 (34): 31861-31870. doi:10.1074/jbc.m300190200. PMID 12805375 ...
https://en.wikipedia.org/wiki/Apoptosis
CDS1 (gene)CDS1 (gene)
Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...
https://en.wikipedia.org/wiki/CDS1_(gene)
Phospholipase DPhospholipase D
Other members of this family are able hydrolyze other phospholipid substrates, such as cardiolipin, or even the phosphodiester ... Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. ... Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. thesis). RWTH-Aachen University ... PLD5 PC-hydrolyzing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins ...
https://en.wikipedia.org/wiki/Phospholipase_D
CDS2CDS2
Nowicki M (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161-5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335 ... of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin ...
https://en.wikipedia.org/wiki/CDS2
Phospholipid scramblasePhospholipid scramblase
... and its overexpression in cultured cells resulted in increased cardiolipin synthase, activity. As cardiolipin is synthesized in ... The active t-Bid fragment is shown to localize to mitochondria through a positive interaction with cardiolipin. This activated ... M. Nowicki (2006). "Characterization of the Cardiolipin Synthase from Arabidopsis thaliana". Ph.D. Thesis, RWTH-Aachen ... Recent findings suggest that PLSCR3 is involved in regulation of biosynthesis of cardiolipin in mitochondria, ...
https://en.wikipedia.org/wiki/Phospholipid_scramblase
Cytochrome cCytochrome c
... and cardiolipin is oxidized by a peroxidase function of the cardiolipin-cytochrome c complex. The hemoprotein is then detached ... Cytochrome c binds to cardiolipin in the inner mitochondrial membrane, thus anchoring its presence and keeping it from ... While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on ... Orrenius S, Zhivotovsky B (September 2005). "Cardiolipin oxidation sets cytochrome c free". Nature Chemical Biology. 1 (4): 188 ...
https://en.wikipedia.org/wiki/Cytochrome_c
TafazzinTafazzin
Ye C, Shen Z, Greenberg ML (April 2016). "Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and ... Barth syndrome patients exhibit defects in cardiolipin metabolism, including aberrant cardiolipin fatty acyl composition, ... After its synthesis, cardiolipin cannot exert its proper functions until it is actively remodeled. Tafazzin, an acyl-specific ... Cardiolipin is a complex glycerophospholipid which contains 4 acyl groups linked to three glycerol moietie localized in the ...
https://en.wikipedia.org/wiki/Tafazzin
Levamisole induced necrosis syndromeLevamisole induced necrosis syndrome
Erythrocyte sedimentation rate was elevated at 35 mm/hour; cardiolipin IgM was weakly positive at 16.3; C4 was decreased at 10 ...
https://en.wikipedia.org/wiki/Levamisole_induced_necrosis_syndrome
SymbiogenesisSymbiogenesis
A membrane lipid cardiolipin is exclusively found in the inner mitochondrial membrane and bacterial cell membranes. Some ... Mileykovskaya, E.; Dowhan, W. (October 2009). "Cardiolipin membrane domains in prokaryotes and eukaryotes". Biochimica et ... that cardiolipin is found only in the inner mitochondrial membrane and bacterial cell membranes; and that some mitochondria and ...
https://en.wikipedia.org/wiki/Symbiogenesis
Phomoxanthone APhomoxanthone A
Mileykovskaya, E; Dowhan, W (2009). "Cardiolipin Membrane Domains in Prokaryotes and Eukaryotes". Biochimica et Biophysica Acta ...
https://en.wikipedia.org/wiki/Phomoxanthone_A
Apolipoprotein HApolipoprotein H
One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in ... Borchman D, Harris EN, Pierangeli SS, Lamba OP (1995). "Interactions and molecular structure of cardiolipin and beta 2- ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin ...
https://en.wikipedia.org/wiki/Apolipoprotein_H
Methylophaga muralisMethylophaga muralis
The main phospholipids are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. Ectoine, glutamate, and, to a ...
https://en.wikipedia.org/wiki/Methylophaga_muralis
Raccoonpox virusRaccoonpox virus
Identify via agglutination with cardiolipin sensitive chicken erythrocytes. RCN infected Strain 143 human osteosarcoma cells ...
https://en.wikipedia.org/wiki/Raccoonpox_virus
Angomonas deaneiAngomonas deanei
In addition it contains cardiolipin and phosphatidylcholine as the major phospholipids, while sterols are absent. Cardiolipin ...
https://en.wikipedia.org/wiki/Angomonas_deanei
PhosphatidylglycerolPhosphatidylglycerol
... combines with CDP-DAG forming cardiolipin releasing CMP by the action of cardiolipin synthase. Two ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... The mechanism of cardiolipin biosynthesis in liver mitochondria. Biochim Biophys Acta. 1972 Mar 23;260(3):507-13. doi: 10.1016/ ... In eukaryotic mitochondria phosphatidylglycerol is converted to cardiolipin by reacting with a molecule of cytidine diphosphate ...
https://en.wikipedia.org/wiki/Phosphatidylglycerol
UQCC3UQCC3
Alpha helices 2 and 3 bind to cardiolipin. The UQCC3 gene encodes a protein that functions in complex III assembly, downstream ... Desmurs M, Foti M, Raemy E, Vaz FM, Martinou JC, Bairoch A, Lane L (April 2015). "C11orf83, a mitochondrial cardiolipin-binding ... Depletion of this protein alters cardiolipin composition, causing cellular and mitochondrial defects. The UQCC3 gene is located ... Depleted levels of the UQCC3 protein cause impaired respiration and subtle yet significant alterations in cardiolipin ...
https://en.wikipedia.org/wiki/UQCC3
Ram RajasekharanRam Rajasekharan
Yadav, Pradeep Kumar; Rajasekharan, Ram (2017). "Cardiolipin deficiency causes triacylglycerol accumulation in Saccharomyces ...
https://en.wikipedia.org/wiki/Ram_Rajasekharan
MSU-DOE Plant Research LaboratoryMSU-DOE Plant Research Laboratory
Pan, Ronghui; Jones, A. Daniel; Hu, Jianping (2014-02-28). "Cardiolipin-Mediated Mitochondrial Dynamics and Stress Response in ...
https://en.wikipedia.org/wiki/MSU-DOE_Plant_Research_Laboratory
Barth syndromeBarth syndrome
Cardiolipin is intimately connected with the electron transport chain proteins and the membrane structure of the mitochondrion ... Kulik found that every patient with Barth Syndrome that he tested had abnormalities in their cardiolipin, a lipid found inside ... Claypool SM, Boontheung P, McCaffery JM, Loo JA, Koehler CM (December 2008). "The cardiolipin transacylase, tafazzin, ... December 2000). "Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome". Biochemical and Biophysical ...
https://en.wikipedia.org/wiki/Barth_syndrome
Inner mitochondrial membraneInner mitochondrial membrane
Phosphatidylcholine makes up about 26.5%, cardiolipin 25.4%, and phosphatidylinositol 4.5%. In S. cerevisiae mitochondria, ... cardiolipin 16.1%, phosphatidylserine 3.8%, and phosphatidic acid 1.5%. In the inner mitochondrial membrane, the protein-to- ...
https://en.wikipedia.org/wiki/Inner_mitochondrial_membrane
Mitochondrial trifunctional proteinMitochondrial trifunctional protein
Although MLCL AT-1 and MTP are different proteins, in 2012 the same lab discovered that MTP did indeed have cardiolipin ... This suggests a possible link between mitochondrial membrane cardiolipin content and beta oxidation. Disorders associated MTP ... "Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation". PLOS ONE. 7 (11): e48628. Bibcode:2012PLoSO ... linking MTP to the remodeling of cardiolipin from monolysocardiolipin. ...
https://en.wikipedia.org/wiki/Mitochondrial_trifunctional_protein
Monolysocardiolipin acyltransferaseMonolysocardiolipin acyltransferase
... into cardiolipin. In 1990, biologists Michael Schlame and Bernd Rustow observed the deacylation of cardiolipin into MLCL, which ... producing cardiolipin. This lipid remodeling is separate from the cardiolipin synthesis pathway, and is essential to maintain ... Since cardiolipin content is significantly diminished in the inner mitochondrial membrane during apoptosis, the increase of ... Taylor WA, Mejia EM, Mitchell RW, Choy PC, Sparagna GC, Hatch GM (2012). "Human trifunctional protein alpha links cardiolipin ...
https://en.wikipedia.org/wiki/Monolysocardiolipin_acyltransferase
TafazziTafazzi
Corcelli, Angela; Schlame, Michael (2016-06-01). "Cardiolipin as key lipid of mitochondria in health and disease. 2nd Edition, ...
https://en.wikipedia.org/wiki/Tafazzi
CerebritisCerebritis
The two antibodies implicated are anti-cardiolipin and lupus anticoagulant. Anti-cardiolipin antibodies attach to the ...
https://en.wikipedia.org/wiki/Cerebritis
SupercomplexSupercomplex
... and in particular requires the presence of cardiolipin, a unique mitochondrial lipid. In yeast mitochondria lacking cardiolipin ... Zhang, M. (2005). "Cardiolipin Is Essential for Organization of Complexes III and IV into a Supercomplex in Intact Yeast ... 2009), cardiolipin stabilizes the supercomplex formation by neutralizing the charges of lysine residues in the interaction ... CARDIOLIPIN IS REQUIRED FOR SUPERCOMPLEX FORMATION IN THE INNER MITOCHONDRIAL MEMBRANE". Journal of Biological Chemistry. 277 ( ...
https://en.wikipedia.org/wiki/Supercomplex
Browsing by Subject CardiolipinsBrowsing by Subject "Cardiolipins"
Cardiolipin antigens : preparation and chemical and serological control / Mary C. Pangborn ... [‎et al.]‎  ...
https://extranet.who.int/iris/restricted/browse?authority=Cardiolipins&type=mesh
Cardiolipin AntibodyCardiolipin Antibody
Cardiolipin antibodies (IgG, IgM, IgA), anticardiolipin What is this test?. A cardiolipin antibodies test measures the ... When high levels of cardiolipins are found in people with these or other issues, it is known as cardiolipin antibody syndrome. ... The results of a cardiolipin antibodies test are easy to understand. If youre negative for cardiolipin antibodies, that is ... as they relate to the amount of cardiolipins. Cardiolipin is a phospholipid, or lipid (fat) molecule, in the blood. The levels ...
https://baycare.org/health-library/cardiolipin-antibody
Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in LiposomesRole of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes
Remodeling of the acyl chain compositions of cardiolipin (CL) species by the transacylase tafazzin is an important process for ... Role of Acyl Chain Composition of Phosphatidylcholine in Tafazzin-Mediated Remodeling of Cardiolipin in Liposomes Biochemistry ... Remodeling of the acyl chain compositions of cardiolipin (CL) species by the transacylase tafazzin is an important process for ...
https://pubmed.ncbi.nlm.nih.gov/29091407/
A synthetic route to cardiolipins - WRAP: Warwick Research Archive PortalA synthetic route to cardiolipins - WRAP: Warwick Research Archive Portal
The phospholipid cardiolipin was found to be exclusively located in the inner membrane of the mitochondrion in eukaryotic cells ... Since no coherent review on cardiolipin has been published, there is presented here (Chapter 1) an up-to-date (concluded with ... Starting from1, 2-diacyl-sn-glycerols three cardiolipin species were prepared in a yield of 20 - 28% by a four step sequence ... overview of what is known about and what has been proposed for cardiolipins. Bis-phosphatidic acids are also reviewed since, ...
http://wrap.warwick.ac.uk/138138/
Anti-cardiolipin and anti-β2-glycoprotein I (β2GP-I) antibody assays as screening for anti-phospholipid syndrome - IOS PressAnti-cardiolipin and anti-β2-glycoprotein I (β2GP-I) antibody assays as screening for anti-phospholipid syndrome - IOS Press
Anti-cardiolipin and anti-β2-glycoprotein I (β2GP-I) antibody assays as screening for anti-phospholipid syndrome Article type: ...
https://content.iospress.com/articles/human-antibodies/hab00075
MCLIP - Overview: Phospholipid (Cardiolipin) Antibodies, IgM, SerumMCLIP - Overview: Phospholipid (Cardiolipin) Antibodies, IgM, Serum
Purified cardiolipin antigen is bound to the wells of a polystyrene microwell plate under conditions that will preserve the ... Prediluted controls and diluted patient sera are added to separate wells, allowing any cardiolipin antibodies present to bind ... After stopping the enzymatic production of colored product, the presence or absence of cardiolipin antibody is determined by ... the source of cardiolipin and/or B2GPI, aPL antibody class (IgG, IgM, or IgA) and level as well as whether antibody positivity ...
https://www.mayocliniclabs.com/test-catalog/overview/81900
Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy<...
Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. In: ... Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. ... Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. / ... Prevalence of anti-cardiolipin, anti-β2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy. ...
https://moh-it.pure.elsevier.com/en/publications/prevalence-of-anti-cardiolipin-anti-%CE%B22-glycoprotein-i-and-anti-pr
Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus...Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus...
Cardiolipins Cerebral Cortex Hippocampus Male Rats Rats, Sprague-Dawley Spectrometry, Mass, Matrix-Assisted Laser Desorption- ... Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus ... Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and Thalamus ... Title : Imaging Mass Spectrometry Reveals Loss of Polyunsaturated Cardiolipins in the Cortical Contusion, Hippocampus and ...
https://stacks.cdc.gov/view/cdc/44348
Details for: Cardiolipin antigens : › WHO HQ Library catalog
Cardiolipin antigens : preparation and chemical and serological control / Mary C. Pangborn ... [et al.] Contributor(s): ... Cardiolipins , Syphilis serodiagnosisNLM classification: QU 93Online resources: Click here to access online ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=su%3A%7BSyphilis%7D%20and%20location%3AONLINE&sort_by=relevance_dsc&count=20&limit=au:Pangborn,%20Mary%20C.
Anti-CardiolipinAnti-Cardiolipin
REAADS Anti-Cardiolipin (aCL) IgM. ELISA Kit/192 tests IVD 13529 REAADS Anti-Cardiolipin (aCL) IgG/IgM. ELISA Kit/96 tests IVD ... REAADS Anti-Cardiolipin (aCL) IgA. ELISA Kit/192 tests IVD 13530 REAADS Anti-Cardiolipin (aCL) IgG. ELISA Kit/192 tests IVD ... Products ❳ Hemostasis ❳ Hemostasis Autoimmunity ❳ Anti-Cardiolipin. Anti-Cardiolipin. Anti-Cardiolipin antibodies (IgG, IgM, ... REAADS Anti-Cardiolipin (aCL) IgG/IgM. ELISA Kit/288 tests IVD K023-002 - Discontinued. Replacement: K023-001 ...
https://diapharma.com/products/hemostasis/hemostasis-autoimmunity/anti-cardiolipin/
Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different...Use of the fluorescent dye 10-N-nonyl acridine orange in quantitative and location assays of cardiolipin: a study on different...
... due to interaction with cardiolipin, is significantly modified by factors that control the spatial arrangement of cardiolipin ... thus confirming that reliable measurements of cardiolipin concentration can be obtained only when the NAO/cardiolipin molar ... due to interaction with cardiolipin, is significantly modified by factors that control the spatial arrangement of cardiolipin ... thus confirming that reliable measurements of cardiolipin concentration can be obtained only when the NAO/cardiolipin molar ...
https://iris.unimore.it/handle/11380/305540
Anti- Cardiolipin IgM - goldenbiotechnologies.comAnti- Cardiolipin IgM - goldenbiotechnologies.com
Be the first to review "Anti- Cardiolipin IgM" Cancel reply. Your email address will not be published. Required fields are ... Home REAGENTS/ASSAYS ELISA Kits AUTOIMMUNE DISEASES ELISA KITS Anti- Cardiolipin IgM ...
https://goldenbiotechnologies.com/product/anti-cardiolipin-igm/
RELISA® Cardiolipin Screen - Português - Immuno ConceptsRELISA® Cardiolipin Screen - Português - Immuno Concepts
This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience ...
https://immunoconcepts.com/support/sds/relisa-acl-test-sys-pt/
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Cardiolipin Antibody Igm Elevated - ChIP-Grade AntibodiesCardiolipin Antibody Igm Elevated - ChIP-Grade Antibodies
Home / Cardiolipin Antibody Igm Elevated Cardiolipin Antibody Igm Elevated. Lab Reagents Igm Antibody Laboratories manufactures ... Other Cardiolipin products are available in stock. Specificity: Cardiolipin Category: Antibody Group: Igm Elevated ... The Cardiolipin Antibody Igm Elevated reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To ... Description: A sandwich ELISA for quantitative measurement of Rat anti cardiolipin antibody IgM,ACA IgM in samples from blood, ...
https://chipgrade.com/cardiolipin-antibody-igm-elevated/
Cardiolipin Synthesis & Protein Import During mtUPR - Lipotype GmbHCardiolipin Synthesis & Protein Import During mtUPR - Lipotype GmbH
Cardiolipin profile: Comparison of cardiolipin species in wild-type and mas1ts mitochondria after induction of mtUPR for four ... Cardiolipins: Cardiolipins belong to the phospholipids. Their structure consists of two diacyl-glycerophosphates linked to each ... Cardiolipin Synthesis & Protein Import During mtUPR. Research Article The mtUPR in yeast exhibits an initial increase in ... For example, cardiolipin constitutes 15-20% of the inner mitochondrial membrane and is rarely found in other cellular membranes ...
https://www.lipotype.com/lipidomics-applications/mitochondrial-unfolded-protein-response-mtupr/
Anti Cardiolipin Antibodies IgA, Serum ₹ - 1800 | RANBAXY DIAGNOSTICSAnti Cardiolipin Antibodies IgA, Serum ₹ - 1800 | RANBAXY DIAGNOSTICS
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Cardiolipin Antibody | UCLA Health Library, Los Angeles, CACardiolipin Antibody | UCLA Health Library, Los Angeles, CA
Try looking up a doctor, a clinic location, or information about a condition/treatment ...
https://healthinfo.uclahealth.org/RelatedItems/RelatedDocuments.pg?d=&TypeId=167&ContentId=cardiolipin_antibody&Category=DC
Systemic Lupus Erythematosus (SLE) Treatment & Management: Approach Considerations, Pivotal and New Lupus Therapies, Emergency...Systemic Lupus Erythematosus (SLE) Treatment & Management: Approach Considerations, Pivotal and New Lupus Therapies, Emergency...
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that has protean manifestations and follows a relapsing and remitting course. More than 90% of cases of SLE occur in women, frequently starting at childbearing age.
https://www.medscape.com/answers/332244-19839/how-effective-is-belimumab-benlysta-in-the-treatment-of-systemic-lupus-erythematosus-sle
3202 AESKULISA Cardiolipin-Check Instruction Manual (DE) - AESKU.GROUP - Experts in Diagnostics3202 AESKULISA Cardiolipin-Check Instruction Manual (DE) - AESKU.GROUP - Experts in Diagnostics
Instruction Manual for AESKULISA Cardiolipin-Check (REF 3202) in german language. For professional usage only!... ... pdf 3202 AESKULISA Cardiolipin-Check Instruction Manual (DE) Popular Tagged in German (DE) ... Instruction Manual for AESKULISA Cardiolipin-Check (REF 3202) in german language. For professional usage only! ...
https://aesku.com/index.php/service/downloads/diagnostics/instruction-manuals/aeskulisa/german/378-3202-aeskulisa-cardiolipin-check-instruction-manual-de
Book CARDIOLIPIN ANTIBODY (ACL) - IgA test in Pudukottai at 60 % off on priceBook CARDIOLIPIN ANTIBODY (ACL) - IgA test in Pudukottai at 60 % off on price
Get reports for CARDIOLIPIN ANTIBODY (ACL) - IgA blood test in 24 Hrs in Pudukottai . Book Thyrocare test on Mediyaar.com. ... CARDIOLIPIN ANTIBODY (ACL) - IgA test can be booked online at low price in Pudukottai now , ... CARDIOLIPIN ANTIBODY (ACL) - IgA test can booked online at a discounted price in Pudukottai . CARDIOLIPIN ANTIBODY (ACL) - IgA ... CARDIOLIPIN ANTIBODY (ACL) - IgA test in Pudukottai To help investigate inappropriate blood clot formation, to help determine ...
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Science Clips - Volume 12, Issue 15, May 15, 2020Science Clips - Volume 12, Issue 15, May 15, 2020
METHODS: Cardiolipin was modified and coupled to magnetic microbeads. Serum diluted in phosphate-buffered saline was mixed with ... cardiolipin-coupled beads and incubated in a round bottom microplate for 90-120 min followed by visual inspection. A panel of ...
https://www.cdc.gov/library/sciclips/issues/v12issue15.html
MEGDEL syndrome: MedlinePlus GeneticsMEGDEL syndrome: MedlinePlus Genetics
Another phospholipid called cardiolipin is made from phosphatidylglycerol. Cardiolipin is a component of the membrane that ... As a result, phosphatidylglycerol remodeling is impaired, which likely alters the composition of cardiolipin. Researchers ... speculate that the abnormal cardiolipin affects mitochondrial function, reducing cellular energy production and leading to the ...
https://medlineplus.gov/genetics/condition/megdel-syndrome
Cardiolipin liposomes specifically inhibit HIV-1 infectivity by Krystyna Konopka, B. R. Davis et al."Cardiolipin liposomes specifically inhibit HIV-1 infectivity" by Krystyna Konopka, B. R. Davis et al.
Konopka, K., Davis, B. R., Larsen, C. E., & Düzgüneş, N. (1991). Cardiolipin liposomes specifically inhibit HIV-1 infectivity. ...
https://scholarlycommons.pacific.edu/dugoni-facpres/244/
Cells | Free Full-Text | Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic SteatohepatitisCells | Free Full-Text | Mitochondria and the NLRP3 Inflammasome in Alcoholic and Nonalcoholic Steatohepatitis
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation. Immunity 2013, 39, 311-323. [Google Scholar] [CrossRef ... Cardiolipin translocation. Decreased mGSH Ox-mtDNA. Loss of MMP. Impaired mitophagy. Inflammasome complex activation (MAMs). ... The NLRP3 inflammasome complex activation is located in MAMs, where cardiolipin translocation and Ca2+ influx by VDAC occurs, ... The NLRP3 inflammasome complex activation is located in MAMs, where cardiolipin translocation and Ca2+ influx by VDAC occurs, ...
https://www.mdpi.com/2073-4409/11/9/1475
PHOSPHOLIPID Syndrome Panel*Cardiolipin Antibodies IgG & IgM*Phospholipid Antibodies Panel *Lupus Anticoagulant by dRVVT -...PHOSPHOLIPID Syndrome Panel*Cardiolipin Antibodies IgG & IgM*Phospholipid Antibodies Panel *Lupus Anticoagulant by dRVVT -...
PHOSPHOLIPID Syndrome Panel*Cardiolipin Antibodies IgG & IgM*Phospholipid Antibodies Panel *Lupus Anticoagulant by dRVVT. ... PHOSPHOLIPID Syndrome Panel*Cardiolipin Antibodies IgG & IgM*Phospholipid Antibodies Panel *Lupus Anticoagulant by dRVVT ... PHOSPHOLIPID Syndrome Panel*Cardiolipin Antibodies IgG & IgM*Phospholipid Antibodies Panel *Lupus Anticoagulant by dRVVT ...
https://homehealth.trackhub.ng/product/phospholipid-syndrome-panelcardiolipin-antibodies-igg-igmphospholipid-antibodies-panel-lupus-anticoagulant-by-drvvt/
Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization | Nature...Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization | Nature...
The analysis of natively bound lipids showed that cardiolipins are by far the most predominant. A key cardiolipin was observed ... form a hydrophobic dimer interface with cardiolipins (CDL, red). Cardiolipin density is carved 2.6 Å around atoms in Fo-dimer ... e Cardiolipins sequestered in the Fo-subcomplex. CDLm corresponds to matrix leaflet lipids, CDLl corresponds to luminal leaflet ... Mühleip, A., McComas, S. E. & Amunts, A. Structure of a mitochondrial ATP synthase with bound native cardiolipin. Elife 8, 1-23 ...
https://www.nature.com/articles/s41467-020-18993-6?error=cookies_not_supported&code=282ea313-3d66-44c5-bc66-28cd17e5457a
PLEKHN1 pleckstrin homology domain containing N1 [Homo sapiens (human)] - Gene - NCBIPLEKHN1 pleckstrin homology domain containing N1 [Homo sapiens (human)] - Gene - NCBI
enables cardiolipin binding IBA Inferred from Biological aspect of Ancestor. more info ... Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule. Sano E, et al. ...
https://www.ncbi.nlm.nih.gov/gene/84069
2022 BSF SciMed Symposium2022 BSF SciMed Symposium
Cardiolipin in Physiology. Chaired by Steven Claypool, Johns Hopkins University. Cardiolipin coordinates lipolysaccharide- ... Cardiolipin bound to mitochondrial ADP/ATP carrier supports the structure and transport-related function - Nanami Senoo, Johns ... Advances in understanding cardiolipin synthesis and pathological effects of dysregulation in cells and animals - Robin E. ... Cardiolipin metabolism regulates myoD1 expression and muscle development Linh Vo - Wayne State University (Watch Video) ...
https://barthsyndrome.org/research/virtual-symposiums/2022-scimedsymposium/
AntibodyAntibodiesSynthaseSynthesisLipidsRole of cardiolipinPresence of cardiolipinMembranesLiposomesMitochondria-specific phospholipidPhospholipid cardiolipinLipidMoleculePhosphatidylglycerolMolar ratioCytochromeMembraneSpeciesSyndromeMoleculesPhosphateRespiratoryFoundChemistryHumanFunctionsUniqueReview
Antibody9
  • When high levels of cardiolipins are found in people with these or other issues, it is known as cardiolipin antibody syndrome. (baycare.org)
  • If you're positive, you might have cardiolipin antibody syndrome and will probably be retested to see if the antibody stays in your blood. (baycare.org)
  • Igm Antibody Laboratories manufactures the cardiolipin antibody igm elevated reagents distributed by Genprice. (chipgrade.com)
  • The Cardiolipin Antibody Igm Elevated reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (chipgrade.com)
  • Description: A sandwich ELISA for quantitative measurement of Rat anti cardiolipin antibody IgM,ACA IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (chipgrade.com)
  • Description: A sandwich ELISA for quantitative measurement of Human anti cardiolipin antibody IgM,ACA IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (chipgrade.com)
  • CARDIOLIPIN ANTIBODY (ACL) - IgA blood test in Pudukottai is done at fully automated NABL accredited diagnostic laboratory Thyrocare which has Centralized Processing Lab in Mumbai for esoteric tests and Regional Processing Labs in major cities of India. (mediyaar.com)
  • Mediyaar Healthcare in Pudukottai provides online facility for booking of CARDIOLIPIN ANTIBODY (ACL) - IgA where sample can be collected from your home or offce in Pudukottai. (mediyaar.com)
  • CusabioHuman anti-cardiolipin antibody (IgG) ELISA Kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment. (joplink.net)
Antibodies14
  • A cardiolipin antibodies test measures the concentration of the antibodies IgG (immunoglobulin G), IgA (immunoglobulin A), and IgM (immunoglobulin M) as they relate to the amount of cardiolipins. (baycare.org)
  • Your health care provider may order a cardiolipin antibodies test if you are having frequent and abnormal blood clot formation or abnormal bleeding. (baycare.org)
  • Finally, some autoimmune diseases, such as lupus, are related to the presence of cardiolipin antibodies in the blood. (baycare.org)
  • The cardiolipin antibodies test is usually just one of many tests given. (baycare.org)
  • The results of a cardiolipin antibodies test are easy to understand. (baycare.org)
  • If you're negative for cardiolipin antibodies, that is normal. (baycare.org)
  • Although cardiolipin antibodies are commonly related to lupus, a positive test for them doesn't mean you have lupus. (baycare.org)
  • Purpose: To measure anti-cardiolipin (aCL), anti-β 2 glycoprotein I (anti-β2GPI), and anti-prothrombin (aPT) antibodies in young patients with epilepsy, and to correlate their presence with demographic data, clinical diagnoses, laboratory and neuroradiologic findings, and antiepileptic drugs (AEDs). (elsevier.com)
  • Anti-Cardiolipin antibodies (IgG, IgM, and IgA) are associated with arterial and venous thrombosis, thrombocytopenia, and recurrent fetal loss (antiphospholipid syndrome). (diapharma.com)
  • Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and Anti-Annexin V Antibodies. (ncbcs.org)
  • The RPR test measures IgM and IgG antibodies to lipoidal material released from damaged host cells, as well as to lipoprotein-like material and possibly cardiolipin released from the treponemes. (cdc.gov)
  • Testing for cardiolipin antibodies and beta-2 glycoprotein antibodies is negative, and lupus anticoagulant testing is positive (while the patient is on anticoagulation). (medscape.com)
  • Detection of Anti-Cardiolipin and Anti-Β2glycoprotein I Antibodies Differs between Platforms without Influence on Association with Clinical Symptoms. (krakow.pl)
  • Nontreponemal tests, such as the Rapid Plasma Reagin (RPR) test and Venereal Disease Research Laboratory (VDRL) test, detect antibodies to cardiolipin and are not specific for treponemal infection. (cdc.gov)
Synthase3
  • In the prokaryotic pathway, the first and the third reactions are catalyzed by phosphatidylglycerol phosphate synthase (Pgps) belonging to the transferase family and cardiolipin synthase (Cls) belonging to the hydrolase family, while in the eukaryotic pathway, those same reactions are catalyzed by unrelated homonymous enzymes: Pgps of the hydrolase family and Cls of the transferase family. (silverchair.com)
  • In eukaryotic cells, CLS (cardiolipin synthase) is involved in the final step of cardiolipin synthesis by catalysing the transfer of a phosphatidyl residue from CDP-DAG (diacylglycerol) to PG (phosphatidylglycerol). (uthscsa.edu)
  • Furthermore, overexpression of hCLS1 cDNA in COS-7 cells resulted in a significant increase in cardiolipin synthesis in intact COS-7 cells without any significant effects on the activity of the endogenous phosphatidylglycerophosphate synthase of the transfected COS-7 cells. (uthscsa.edu)
Synthesis4
  • These molecules arose as by-products in our chemical synthesis of cardiolipins. (warwick.ac.uk)
  • In Chapter 2, the current available methodology for the chemical synthesis of cardiolipins is reviewed. (warwick.ac.uk)
  • Unsuccessful application of two phosphorylating agents, bis-(0, g, 0- trichloroethyl) phosphorochloridate and CAP-anhydrides, CXV, to phospholipid chemistry is outlined in Chapter 7, while the successful application of CEP-O-CEP, CXXVIII, for the chemical synthesis of cardiolipins is presented in Chapter 8. (warwick.ac.uk)
  • The recombinant hCLS1 enzyme expressed in COS-7 cells catalysed efficiently the synthesis of cardiolipin in vitro using CDP-DAG and PG as substrates. (uthscsa.edu)
Lipids2
  • cardiolipin lipids in the membrane models using packmol? (ambermd.org)
  • Anionic lipids, especially cardiolipin, initiate a concerted rotation of the cytoplasmic domain subunits. (tcdb.org)
Role of cardiolipin1
  • Despite an important role of cardiolipin in regulating mitochondrial function, a gene encoding the mammalian CLS has not been identified so far. (uthscsa.edu)
Presence of cardiolipin1
  • The aim of this research was to investigate the effects of some experimental factors on the selective fluorescence of NAO in the presence of cardiolipin in artificial and natural membranes (mitochondria). (unimore.it)
Membranes1
  • Cardiolipin (CL) is known as mitochondria-specific phospholipid since it is almost exclusively biosynthesized and located in the inner mitochondrial membranes. (encapsula.com)
Liposomes6
  • Cardiolipin liposomes specifically inhibit HIV-1 infectivity" by Krystyna Konopka, B. R. Davis et al. (pacific.edu)
  • Extensive studies [23-29] of pharmacological, toxicological, and therapeutic effects have shown that the incorporation of doxorubicin in cardiolipin liposomes improved the antitumor activity of doxorubicin, while the histopathologic lesions in cardiac tissue of mice significantly decreased. (encapsula.com)
  • It has been reported that cardiolipin-containing liposomes have lower (at least 2-fold lower than that observed with conventional doxorubicin) cardiotoxicity associated with doxorubicin by altering the pharmacokinetics and tissue distribution of the drug in mice [29]. (encapsula.com)
  • Hence, the cardiolipin-liposomes has been suggested as a convenient carrier for doxorubicin delivery to increase the therapeutic index of the drug [23]. (encapsula.com)
  • Cellsome® made from cardiolipin lipid catalog containing many different types of saturated and unsaturated cardiolipin based liposomes made from 0.5 up to 100 percent of cardiolipin. (encapsula.com)
  • Cellsome®-Cardiolipin liposomes are unilamellar and sized to 100 nm. (encapsula.com)
Mitochondria-specific phospholipid1
  • This review is focused on a newly discovered early stage of mitochondria-dependent apoptosis - oxidative lipid signaling involving a mitochondria-specific phospholipid cardiolipin (CL). (cdc.gov)
Phospholipid cardiolipin1
  • The phospholipid cardiolipin was found to be exclusively located in the inner membrane of the mitochondrion in eukaryotic cells. (warwick.ac.uk)
Lipid3
  • Cardiolipin is a phospholipid, or lipid (fat) molecule, in the blood. (baycare.org)
  • Cardiolipin is a negatively charged lipid. (encapsula.com)
  • Dear colleague, This message is to let you know that we are organizing a second workshop dedicated to cardiolipin, the signature lipid of mitochondria, as a satellite meeting to the 13th Euro Fed Lipid congress to be held in Florence, on 27-30 September 2015. (dgfett.de)
Molecule3
  • In an effort to achieve a quick, efficient method for -unsaturated cardiolipins, a detailed study on the preparation and chemistry of various components of the cardiolipin molecule was carried out. (warwick.ac.uk)
  • The structure of 18:1 cardiolipin molecule with an anionic headgroup. (encapsula.com)
  • The structure of 14:0 cardiolipin molecule with an anionic headgroup. (encapsula.com)
Phosphatidylglycerol3
  • Another phospholipid called cardiolipin is made from phosphatidylglycerol. (medlineplus.gov)
  • As a result, phosphatidylglycerol remodeling is impaired, which likely alters the composition of cardiolipin. (medlineplus.gov)
  • Cardiolipin (CL) and its precursor phosphatidylglycerol (PG) are important anionic phospholipids widely distributed throughout all domains of life. (silverchair.com)
Molar ratio1
  • Moreover, the present observations suggest that the specific effect of cardiolipin is to facilitate the dimerization of this fluorescent dye, thus confirming that reliable measurements of cardiolipin concentration can be obtained only when the NAO/cardiolipin molar ratio is equal to 2. (unimore.it)
Cytochrome2
  • During apoptosis in presence of H 2 O 2 , CL-bound Cytochrome c catalyzes the peroxidation of cardiolipin, releasing Cytochrome c, which is a death-inducing protein. (encapsula.com)
  • Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. (cdc.gov)
Membrane1
  • The results show that the fluorescence of NAO, due to interaction with cardiolipin, is significantly modified by factors that control the spatial arrangement of cardiolipin molecules within the space of the membrane under investigation. (unimore.it)
Species3
  • Remodeling of the acyl chain compositions of cardiolipin (CL) species by the transacylase tafazzin is an important process for maintaining optimal mitochondrial functions. (nih.gov)
  • Starting from1, 2-diacyl-sn-glycerols three cardiolipin species were prepared in a yield of 20 - 28% by a four step sequence requiring purification only for two of these steps. (warwick.ac.uk)
  • Formation of molecular species of mitochondrial cardiolipin. (bvsalud.org)
Syndrome1
  • Researchers speculate that the abnormal cardiolipin affects mitochondrial function, reducing cellular energy production and leading to the neurological and hearing problems characteristic of MEGDEL syndrome. (medlineplus.gov)
Molecules2
  • Data-driven discovery of cardiolipin-selective small molecules by computational active learning. (mpg.de)
  • The inner lining of the mitochondria is made of cardiolipin, which contains four fat molecules. (drdanenberg.com)
Phosphate1
  • Due to deprotonation of one of these phosphate groups, cardiolipin is negatively charged in physiological pH [1,2]. (encapsula.com)
Respiratory1
  • The finding is also reported that in isolated respiring mitochondria the interaction of NAO with cardiolipin is somewhat related to the respiratory state of mitochondria. (unimore.it)
Found1
  • The name "cardiolipin" is derived from fact that it was first found and isolated from animal heart. (encapsula.com)
Chemistry1
  • Discovery of an intramolecular catalysis by a P-OH group towards a g-located ether bond greatly simplified the synthetic chemistry of cardiolipins. (warwick.ac.uk)
Human1
  • This time, the idea is to draw more connections between cardiolipin research and human pathophysiology. (dgfett.de)
Functions1
  • This one-day workshop will offer the opportunity to discuss various aspects of basic cardiolipin functions in biomembranes of prokaryotes and animal cells. (dgfett.de)
Unique1
  • Cardiolipin (CL) is a unique phospholipid with a very interesting chemical and specific ultrastructural characteristics. (encapsula.com)
Review1
  • Since no coherent review on cardiolipin has been published, there is presented here (Chapter 1) an up-to-date (concluded with December 1975 issue of Chem, Abs. (warwick.ac.uk)