Myocarditis: Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.Coxsackievirus Infections: A heterogeneous group of infections produced by coxsackieviruses, including HERPANGINA, aseptic meningitis (MENINGITIS, ASEPTIC), a common-cold-like syndrome, a non-paralytic poliomyelitis-like syndrome, epidemic pleurodynia (PLEURODYNIA, EPIDEMIC) and a serious MYOCARDITIS.Enterovirus B, Human: A species of ENTEROVIRUS infecting humans and containing 36 serotypes. It is comprised of all the echoviruses and a few coxsackieviruses, including all of those previously named coxsackievirus B.Myocytes, Cardiac: Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Heart: The hollow, muscular organ that maintains the circulation of the blood.Cardiac Output: The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.Cardiac Myosins: Myosin type II isoforms found in cardiac muscle.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Cardiac Surgical Procedures: Surgery performed on the heart.Enterovirus InfectionsCardiomyopathies: A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).Chagas Cardiomyopathy: A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.Enterovirus: A genus of the family PICORNAVIRIDAE whose members preferentially inhabit the intestinal tract of a variety of hosts. The genus contains many species. Newly described members of human enteroviruses are assigned continuous numbers with the species designated "human enterovirus".Acute Disease: Disease having a short and relatively severe course.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Rats, Inbred LewCardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.Endocardium: The innermost layer of the heart, comprised of endothelial cells.Heart Ventricles: The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.Cardiovirus Infections: Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.Encephalomyocarditis virus: The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.Cardiac Pacing, Artificial: Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.Echocardiography: Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Myosins: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.Cardiac Tamponade: Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Pericarditis: Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.Myocardial Contraction: Contractile activity of the MYOCARDIUM.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Edema, Cardiac: Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).Heart Transplantation: The transference of a heart from one human or animal to another.Reoviridae Infections: Infections produced by reoviruses, general or unspecified.Ventricular Function, Left: The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Heart Arrest: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.Troponin I: One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.Virus Diseases: A general term for diseases produced by viruses.Ventricular Remodeling: The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.Endomyocardial Fibrosis: A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Cardiac Output, Low: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Giant Cells: Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Ventricular Dysfunction, Left: A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.Ventricular Myosins: Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Myoblasts, Cardiac: Precursor cells destined to differentiate into cardiac myocytes (MYOCYTES, CARDIAC).Troponin T: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.Mice, Inbred BALB CFatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Cardiac Imaging Techniques: Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.Stroke Volume: The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.Heart Function Tests: Examinations used to diagnose and treat heart conditions.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Cardiac Glycosides: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.Trypanosoma cruzi: The agent of South American trypanosomiasis or CHAGAS DISEASE. Its vertebrate hosts are man and various domestic and wild animals. Insects of several species are vectors.Shock, Cardiogenic: Shock resulting from diminution of cardiac output in heart disease.Out-of-Hospital Cardiac Arrest: Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Magnetic Resonance Imaging, Cine: A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.Mice, Inbred C57BLCardiotonic Agents: Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).Cardiac Volume: The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.Cardiopulmonary Resuscitation: The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Parvovirus B19, Human: The type species of ERYTHROVIRUS and the etiological agent of ERYTHEMA INFECTIOSUM, a disease most commonly seen in school-age children.Heart Block: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Blauwet, Lori A.; Cooper, Leslie T. (31 October 2012). "Idiopathic giant cell myocarditis and cardiac sarcoidosis". Heart ... "Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease". Journal ... "Unresolved issues in theories of autoimmune disease using myocarditis as a framework". Journal of Theoretical Biology. 375: 101 ...
Complications can include cardiac tamponade, myocarditis, and constrictive pericarditis. It is a less common cause of chest ... In such cases of cardiac tamponade, EKG or Holter monitor will then depict electrical alternans indicating wobbling of the ... Chest X-ray usually shows an enlarged cardiac silhouette ("water bottle" appearance) and clear lungs. Pulmonary congestion is ... Imazio, M; Gaita, F (July 2015). "Diagnosis and treatment of pericarditis". Heart (British Cardiac Society). 101 (14): 1159-68 ...
Symptoms can also include cardiac arrhythmias, myocarditis, and cranial and peripheral nerve palsies. Laryngeal diphtheria can ... Abnormal cardiac rhythms can occur early in the course of the illness or weeks later, and can lead to heart failure. Diphtheria ... Myocarditis may result in an abnormal heart rate and inflammation of the nerves may result in paralysis. Diphtheria is usually ... Complications may include myocarditis, inflammation of nerves, kidney problems, and bleeding problems due to low levels of ...
... profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis". ...
The venom produces mainly cardiopulmonary abnormalities like circulatory derangements, myocarditis and changes in cardiac ...
Moreover, experimental inoculation of C. burnetii in cattle induced not only respiratory disorders and cardiac failures ( ... myocarditis), but also frequent abortions and irregular repeat breedings. Beare PA, Samuel JE, Howe D, Virtaneva K, Porcella SF ...
Amongst the viruses capable of causing myocarditis, CVB3 is a common agent identified in inducing cardiac damage. ... it can travel and infect the heart and cause myocarditis. Myocarditis is an inflammation of the heart, most commonly cause by ... resulting in severe and rapid cardiac decompensation. With loss of cardiac cells increasing progressively, infected individual ... The role of the immune system in response to the presence of a virus has both beneficial and detrimental effects on the cardiac ...
... myocarditis and cardiac insufficiency, acute adrenal insufficiency, and nephritis. Cancer immunotherapy#Immune checkpoints ...
Cardiac: Heart attack Pericarditis/myocarditis Aortic aneurysm Gastrointestinal:Gastroesophageal reflux disease Gastritis ... Chest pain is considered a medical emergency until life-threatening cardiac issues (such as an acute coronary syndrome) can be ...
When used as a tocolytic, hexoprenaline is contraindicated in: Hyperthyroidism Cardiovascular diseases, e.g. cardiac ... arrhythmias, tachycardia, myocarditis, mitral valve disease and aortic stenosis Ischemic heart disease Hypertension Angle- ...
Left ventricular aneurysm Blunt trauma to the chest resulting in a cardiac contusion Hyperkalemia Acute myocarditis Pulmonary ... generating a vector that points towards the normal cardiac cells (which have positive charges on their surface). This vector ... a ventricle with subepicardial ischemia will exhibit cells with higher amplitude of depolarization in the cardiac endocardium. ...
... potentially causing inflammation of skeletal and cardiac muscle (myositis and myocarditis), encephalitic signs, and limb edema ...
Eosinophilic myocarditis is a subtype of myocarditis in which cardiac tissue is infiltrated by another type of pro-inflammatory ... myocarditis is the most common cardiac pathological finding at autopsy, with a prevalence of 50% or more. Cases of myocarditis ... Cardiac magnetic resonance imaging (cMRI or CMR) has been shown to be very useful in diagnosing myocarditis by visualizing ... Complications may include heart failure due to dilated cardiomyopathy or cardiac arrest. Myocarditis is most often due to a ...
... myocarditis) account for 10% of all SCDs. Examples of these include: cardiomyopathy, cardiac rhythm disturbances, myocarditis, ... Sudden cardiac arrest can result from cardiac and non-cardiac causes including the following: Coronary artery disease (CAD), ... is sudden death from cardiac causes. However, sometimes physicians call cardiac arrest "sudden cardiac death" even if the ... In those with cardiac arrest due to local anesthetic lipid emulsion may be used. Cooling adults after cardiac arrest who have a ...
Cardiac manifestations of eosinophilic myocarditis range from none to life-threatening conditions such as cardiogenic shock or ... Perhaps less commonly, eosinophilic myocarditis, eosinophilic thrombotic myocarditis, and eosinophilic fibrotic myocarditis are ... Eotaxins are also elevated in the cardiac muscle biopsy specimens of individuals with eosinphilic myocarditis compared to their ... However, the only definitive test for eosinophilic myocarditis in cardiac muscle biopsy showing the presence of eosinophilic ...
... myocarditis, dilated cardiomyopathies, Chagas, cardiac hypertrophy and heart failure, as well as in heart transplant rejection ... Altara R, Mallat Z, Booz GW, Zouein FA (2016). "The CXCL10/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy ... acute cardiac allograft rejection and possibly Celiac Disease. Development of agents to block CXCR3-ligand interactions may ... γ-inducible chemokines and the development of adverse cardiac remodeling. Recent reports indicate that there is a significant ...
Dysplasia, dystrophy, or myocarditis?". Circulation. 94 (5): 983-91. doi:10.1161/01.cir.94.5.983. PMID 8790036. Dorfman, TA; ... cardiac remodeling, and dehydration medications that interfere with the cardiac potassium ion channels. Which of these factors ... Cardiac rhythm disturbances could jeopardize mission objectives and, at the most extreme, the life of crewmembers. The worst- ... Systematic studies of cardiac rhythm disturbances have been performed during short-duration space flight. These studies were ...
Chronic: Valve diseases as noted above; Reduced cardiac output; Exercise intolerance. Intensive cardiac care and ... Myocarditis: Here the muscle bulk of the heart gets inflamed. Inflamed muscles have reduced functional capacity. This may be ... Autoimmune heart diseases are the effects of the body's own immune defense system mistaking cardiac antigens as foreign and ... Acutely, it can cause pericardial effusion leading to cardiac tamponade and death. After healing, there may be fibrosis and ...
Nonneurologic complications of WNV infection that may rarely occur include fulminant hepatitis, pancreatitis, myocarditis, ... rhabdomyolysis, orchitis, nephritis, optic neuritis and cardiac dysrhythmias and hemorrhagic fever with coagulopathy. ...
The heart muscle may become inflamed in a condition called myocarditis, most commonly by viruses but sometimes by the body's ... The ease of ion movement along cardiac muscle fibers axes is such that action potentials are able to travel from one cardiac ... Cardiac fibroblasts are vital supporting cells within cardiac muscle. They are unable to provide forceful contractions like ... Most of the wall is taken up by bricks, which in cardiac muscle are individual cardiac muscle cells or cardiomyocytes. The ...
... of patients have not experienced any opportunistic infection before the onset of cardiac symptoms. Myocarditis has been ... Cardiac autoimmunity in HIV related heart muscle disease. Heart 1998;79:599-604. Lipshultz SE, Easley KA, Orav EJ, et al. ... Nutritional status and cardiac mass and function in children infected with the human immunodeficiency virus. Am J Clin Nutr ... Cardiac dysfunction in the HIV-1 transgenic mouse treated with zidovudine. Lab Invest 2000;80:187-97. Lewis W, Simpson JF, ...
Breathlessness Pink frothy sputum Cardiac dysrhythmia Tachycardia or bradycardia Hypotension or hypertension Acute myocarditis ... Kanoo, S.; M. B. Mandal; A. B. Alex & S. B. Deshpande (2009). "Cardiac dysrhythmia produced by Mesobuthus tamulus venom ...
Myocarditis Coronary Artery Disease (CAD) Ion Channelopathies - Long QT syndrome (inc. Jervell and Lange-Nielsen syndrome & ... Cardiac Risk in the Young. Retrieved 4 December 2015. "Young sudden death cardiac research". Cardiac Risk in the Young. Cardiac ... Surrey, United Kingdom: Cardiac Risk in the Young. 2015. p. 5. "Bereavement". Cardiac Risk in the Young. Cardiac Risk in the ... Cardiac Risk in the Young Test My Heart CRY Centre for Cardiac Pathology Sudden Arrhythmic Death Syndrome myheart Network. ...
Product indications: as a cardiac stimulant and diuretic in cases of heart failure, myocardial insufficiency, myocarditis, ... auricular flutter and fibrillation, edema due to impaired pectoris, and acute infectious myocarditis. ...
Cardiac traumas such as myocardial infarction (commonly called a heart attack), myocarditis, peripartum cardiomyopathy, ... Acute cardiac unloading is able to functionally uncouple the heart from cardiac output, allowing the heart to rest and recover ... Acute cardiac unloading decreases cardiac MVO2 and has been demonstrated to limit the amount of scar tissue that forms, thus ... Maintaining sufficient cardiac output is the primary objective of therapeutic approaches treating these cardiac conditions. ...
Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, narrow complex rhythm. ... Ventricular tachycardia (VT or V-tach) is a potentially life-threatening cardiac arrhythmia that originates in the ventricles. ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ... Unstable means that either important organ functions are affected or cardiac arrest is about to occur. ...
Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease ... without interfering with vascularization or myocarditis intensity. Resveratrol was even capable of improving heart function of ... improved stroke volume and cardiac output. Resveratrol activated the AMPK-pathway and reduced both ROS production and heart ...
Development of New Cardiac Deformity Indexes for Pectus Excavatum on Computed Tomography: Feasibility for Pre- and Post- ... Trypanosoma cruzi infection in humans and experimental animals causes Chagas disease which is often accompanied by myocarditis ... The present study used magnetic resonance un-aging to assess changes in the cardiac morphology of infected mice after therapy ... Important pathophysiological mechanisms involved in the cardiac lesions include activation of the endothelium and induced ...
... Diana Lindner,1,2 Jia Li,1 ... Significantly different versus cardiac fibroblasts; ; significantly different versus cardiomyocytes; ; (c) significantly ... Myocarditis is an inflammatory disease of the heart muscle often resulting in cardiac dysfunction and death, especially in ... Inflammation during Viral Myocarditis. First, we analyzed the cardiac tissue from B6 mice, which were peritoneally infected ...
... ... The myocarditis, revealed by post-mortem histology, was unexpected. The pathological finding of active lymphocytic myocarditis ... L. T. Cooper, "Myocarditis," New England Journal of Medicine, vol. 360, no. 15, pp. 1526-1538, 2009. View at Publisher · View ... Cardiac enzymes were normal (Table 1). A blood film revealed a heavy P. falciparum parasitaemia of 20%. A chest X-ray was ...
CD117+/CD90+ cardiac cells were detected in all biopsies. The highest expression of CD90 was revealed in the myocarditis group ... CD117+/CD90+ cardiac cells were detected in all biopsies. The highest expression of CD90 was revealed in the myocarditis group ... myocarditis and controls from healthy cardiac patients. High-resolution scanning microscopy of the whole slide enabled a ... myocarditis and controls from healthy cardiac patients. High-resolution scanning microscopy of the whole slide enabled a ...
Cardiotropic Viruses in Cardiac Surgery Patients Without Clinical Evidence of Myocarditis or Myocarditic Sequelae. This study ... myocarditis. parvovirus B19 (PVB19). human herpes virus 6 (HHV6). cardiac magnetic resonance tomography (CMR). ... Prevalence of Cardiotropic Viruses in Cardiac Surgery Patients Without Clinical Evidence of Myocarditis or Myocarditic Sequelae ... Correlation of non-invasive myocarditis screening exams (cardiac magnetic resonance, ecg, history, inflammatory markers) with ...
While diagnostic criteria were elaborated for acute myocarditis using cardiac magnetic resonance (CMR) in 2009, studies have ... Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis. ... Acute myocarditis Cardiac magnetic resonance Lake Louise criteria Parametric mapping Meta-analysis ... Diagnostic and prognostic value of cardiac magnetic resonance in acute myocarditis: a systematic review and meta-analysis. ...
Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic ... Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic ... Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic ... Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic ...
The aim of our study was to assess the clinical and economic impact of an early use of cardiac MRI in the management of ... Cardiac MRI directly identifies the presence and exact location of myocardial damage caused by myocarditis. ... OBJECTIVE: Cardiac MRI directly identifies the presence and exact location of myocardial damage caused by myocarditis. The aim ... Early use of cardiac magnetic resonance reduces hospitalization time and costs in patients with acute myocarditis and preserved ...
Kandolin R, Lehtonen J, Kupari M. Cardiac sarcoidosis and giant cell myocarditis as causes of atrioventricular block in young ... Importance of endomyocardial biopsy in distinguishing between cardiac sarcoidosis and giant cell myocarditis. Need to ... Importance of endomyocardial biopsy in distinguishing between cardiac sarcoidosis and giant cell myocarditis. Need to ... Shabetai R. Idiopathic giant-cell myocarditis-natural history and treatment. Multicenter Giant Cell Myocarditis Study Group ...
Figure 2. MRM imaging of mice affected with autoimmune myocarditis reveals cardiac abnormalities. Myocarditis was induced in A/ ... Neu, N., et al. Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity. Eur Heart J. 12 Suppl D, 117-120 ... Pummerer, C. L., et al. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J ... The disease can be induced in myocarditis-susceptible A/J and Balb/c mice by immunizing the animals with cardiac myosin heavy ...
Cardiac MRI Findings Suggest Myocarditis in Severe Ebola Virus Disease. Daniel S. Chertow, Richard W. Childs, Andrew E. Arai, ... Cardiac MRI Findings Suggest Myocarditis in Severe Ebola Virus Disease. Daniel S. Chertow, Richard W. Childs, Andrew E. Arai ... Cardiac MRI Findings Suggest Myocarditis in Severe Ebola Virus Disease Message Subject (Your Name) has forwarded a page to you ... including cardiac death, and may be attributable to inflammatory cytokines (4). The contribution of viral myocarditis to ...
cardiac MR. Myocarditis is a common cardiac disease. It appears to be a major cause of sudden death, and may progress to ... Cardiac magnetic resonance appearance of myocarditis caused by high dose IL-2: similarities to community-acquired myocarditis. ... Cardiac magnetic resonance (CMR) has recently emerged as a noninvasive tool to diagnose myocarditis (3-6), as well as to follow ... 2002) [Cardiac MRI in suspected myocarditis]. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 174:1530-1536. ...
20192019The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in MyocarditisThe Cardiac ... The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Hou, X;Chen, G;Bracamonte-Baran, ... We propose that MHCII+Ly6Clo MDMs are associated with the reduction of cardiac fibrosis and prevention of the myocarditis ... We propose that MHCII+Ly6Clo MDMs are associated with the reduction of cardiac fibrosis and prevention of the myocarditis ...
As reported in Table 4, there were 8 major cardiac events (4 sudden cardiac deaths; 2 resuscitated cardiac arrests, 2 ... acute myocarditis. AS. anteroseptal. CMR. cardiac magnetic resonance. CRP. C-reactive protein. ECG. electrocardiographic. EDV. ... Cardiac magnetic resonance images of a case of acute myocarditis with the inferolateral (IL) pattern of LGE. Abbreviations as ... Cardiac magnetic resonance images of a case of acute myocarditis with the anteroseptal (AS) pattern of late gadolinium ...
Ve esta fotografía de stock de Chagas Disease In Cardiac Muscle Of A Patient With Chronic Myocarditis This Serious Disease Is ... Chagas disease in cardiac muscle of a patient with chronic myocarditis. This serious disease is caused by the Protozoa ...
... and elevated cardiac biomarkers as having myocarditis. However, biopsy verification of actual myocarditis was not undertaken in ... Natural History of Myocarditis. The natural history of myocarditis is as varied as its clinical presentations. Myocarditis ... Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol. 1997; 30: 1354-1359. ... Elevations of cardiac troponin I associated with myocarditis: experimental and clinical correlates. Circulation. 1997; 95: 163- ...
Cardiac magnetic resonance (CMR) has become the primary noninvasive tool for the diagnosis and evaluation of myocarditis. The ... Cardiac morphology and function and myocardial tissue characterization at baseline and follow-up CMR were compared using paired ... aim of our study was to assess the CMR findings at different course of FM and the short-term outcomes of fulminant myocarditis ... Background Fulminant myocarditis (FM) is an inflammatory disease of the myocardium that results in ventricular systolic ...
Hypersensitivity myocarditis is a rare form of myocarditis. Numerous drugs can induce myocarditis, which is typically ... Drug-related myocarditis can be classified into five types: 1) hypersensitivity myocarditis; 2) toxic myocarditis; 3) ... Myocarditis. Lancet 2012;379:738-747PMID : 22185868.. 6. Kindermann I, Barth C, Mahfoud F, et al. Update on myocarditis. J Am ... Here, we report a case of hypersensitivity myocarditis, as confirmed by cardiac magnetic resonance imaging (CMR) and ...
Cardiac biomarkers such as troponins and creatine kinase lack specificity, but may help to confirm the diagnosis of myocarditis ... Evaluates cardiac chamber size and wall thickness *Assess systolic and diastolic function *Rule out other causes of cardiac ... Acute myocarditis: lymphocytic infiltrates in association with myocyte necrosis *Borderline myocarditis: inflammatory ... The Myocarditis Treatment Trial reported the incidence of biopsy proven myocarditis in patients with unexplained heart failure ...
... and even sudden cardiac death. Diagnosing myocarditis is challenging with no current uniform clinical gold-standard. CMR is a ... CMR Features in Patients With Suspected Myocarditis (CMRMyo). The safety and scientific validity of this study is the ... Major adverse cardiac events [ Time Frame: through study completion, an average of 2 years ]. Heart failure hospitalization; ... Presentation of myocarditis is heterogeneous, often ranges from being asymptomatic, to chest pain, dyspnoea, palpitations, ...
Diagnosis and Treatment and Related Diseases Myocarditis is inflammation of the heart muscle due to tissue injury or infection ... Cardiac CT scan and MRI. Echocardiography. Cardiac catherization. Treatment:. Treatment of myocarditis is dependent on the ... This book describes Myocarditis, Diagnosis and Treatment and Related Diseases. Myocarditis is inflammation of the heart muscle ... Myocarditis is acute or chronic inflammation of the heart muscle due to reaction of living tissue to injury or infection.. The ...
Sudden cardiac death. Certain serious arrhythmias can cause your heart to stop beating (sudden cardiac arrest). Its fatal if ... Myocarditis. Myocarditis. Myocarditis is inflammation of the heart muscle. This illustration shows normal heart muscle compared ... Severe myocarditis can permanently damage your heart muscle, possibly causing:. *Heart failure. Untreated, myocarditis can ... Myocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your hearts ...
Eosinophilic myocarditis is a subtype of myocarditis in which cardiac tissue is infiltrated by another type of pro-inflammatory ... Cardiac magnetic resonance imaging (cMRI or CMR) has been shown to be very useful in diagnosing myocarditis by visualizing ... Among patients with HIV, myocarditis is the most common cardiac pathological finding at autopsy, with a prevalence of 50% or ... Cases of myocarditis have been documented as early as the 1600s, but the term "myocarditis", implying an inflammatory ...
... (pronounced my-oh-car-DIE-tis) is inflammation of the myocardium, the hearts muscle wall. This muscle contracts to ... cardiac intensivists, cardiac surgeons, respiratory therapists, nurses, child life specialists, social workers and others, if ... Myocarditis in children. In children, the most common cause of myocarditis is a viral infection, such as influenza or the ... What is myocarditis? Myocarditis (pronounced my-oh-car-DIE-tis) is inflammation of the myocardium, the hearts muscle wall. ...
Left ventricularHeartDilated cardiomyopathyViralSuddenCause myocarditisDiagnosis of acute myocarditisFulminantLate gadolinium enhancementSymptomsVentricularPatients with acuteFibrosisHypersensitivity2019AbstractDiseaseIncidenceInfectionChest painPathogenesisCongestiveUnderwentMurineAcute or subacuteDevelop myocarditisPrevalenceHeart failureCoronary angiographyDiagnosed with cardiac insufficiencyIdiopathicInterstitial
- Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. (physiciansweekly.com)
- Resveratrol activated the AMPK-pathway and reduced both ROS production and heart parasite burden, without interfering with vascularization or myocarditis intensity. (physiciansweekly.com)
- This virus-induced myocarditis remains still one major cause of dilated cardiomyopathy. (hindawi.com)
- If enough scar tissue forms in the heart, it can ultimately lead to congestive heart failure or dilated cardiomyopathy as a consequence of myocarditis. (blogspot.com)
- A case of human immunodeficiency virus-related heart failure resembling dilated cardiomyopathy but accompanied by high cardiac output. (nih.gov)
- Surgical treatment may include cardiac transplantation for patients that develop a chronic, symptomatic dilated cardiomyopathy. (medscape.com)
- Myocarditis is an inflammatory heart disease that can lead to dilated cardiomyopathy, arrhythmias, and sudden cardiac death. (auntminnieeurope.com)
- Its use, limited by the well-known agranulocytosis risk, has also been associated with severe cardiovascular side effects and sudden death.1-3 Both dilated cardiomyopathy and myocarditis, as result of direct toxicity and drug hypersensitivity, respectively, have been described at autopsy.2,3 We report a case of hypersensitivity myocarditis secondary to clozapine administration diagnosed for the first time in vivo by endomyocardial biopsy and successfully treated with corticosteroids. (redorbit.com)
- Patients with a slow onset of congestive failure and ventricular dilatation, without a viral prodrome, or with no evidence of inflammation, are often diagnosed with idiopathic dilated cardiomyopathy, rather than viral myocarditis. (oncologynurseadvisor.com)
- However, viral myocarditis may progress to chronic dilated cardiomyopathy, and it is difficult, on clinical grounds, to distinguish patients with myocarditis from those with dilated cardiomyopathy due to other causes. (oncologynurseadvisor.com)
- Viral infections have also been estimated to trigger 35-50% of inflammatory dilated cardiomyopathy (DCMi) and early diagnosis and treatment of viral myocarditis aims to prevent it. (escardio.org)
- Towbin and colleagues reported that the incidence of dilated cardiomyopathy (DCM) in children was 0.57 cases per 100,000 per year overall, 46% of which were caused by myocarditis ( 5 ). (frontiersin.org)
- AbstractIn humans, it is acknowledged that dilated cardiomyopathy is also caused by infection-induced myocarditis. (medworm.com)
- To evaluate whether the occurrence of lesions of dilated cardiomyopathy in cattle may be triggered by myocarditis, an adult Holstein-Friesian dairy cow which showed dilated cardiomyopathy associated with myocarditis was examined by histopathology. (medworm.com)
- Even though the pathogenetical mechanism of dilated cardiomyopathy following myocarditis in humans may not necessarily be applicable to that of the hereditarily determined dilated cardiomyopathy in the cow, the myocardium of latter showed histopathological features similar to some degree to those of the human heart disease. (medworm.com)
- This disease is a precursor to 10%-20% of chronic myocarditis cases and dilated cardiomyopathy (DCM), which is a leading cause of heart transplantation worldwide (2). (thefreedictionary.com)
- Although the majority of EV infections remain asymptomatic, these viruses, especially group B coxsackieviruses (CVB), are considered to be a common cause of acute myocarditis in children and young adults, a disease which is a precursor to 10-20% of chronic myocarditis cases as well as dilated cardiomyopathy (DCM, prevalence = 7 cases / 100,000, second leading cause of heart transplantation worldwide after ischemic heart disease). (thefreedictionary.com)
- An acute viral myocarditis may evolve into chronic myocarditis , leading to a dilated cardiomyopathy in an individual with the above defect. (thefreedictionary.com)
- Myocarditis is an inflammatory disease caused by viral infection. (hindawi.com)
- Due to viral infection, the expression of TNF-α, IL-6, MCP-1, and IFN- β was significantly increased in cardiac fibroblasts compared to cardiomyocytes or macrophages. (hindawi.com)
- CVB3-induced viral myocarditis is a well-established model to elucidate viral myocarditis in mice [ 8 - 14 ]. (hindawi.com)
- But those cytokines can be expressed due to the infiltration of inflammatory cells or due to activation of resident cardiac cells triggered by viral infection [ 18 - 20 ]. (hindawi.com)
- Gold standard diagnostic criteria for viral myocarditis require endomyocardial biopsy using standardized histopathological (Dallas criteria) and immunohistochemical diagnostic criteria (2) . (onlinejacc.org)
- Myocarditis often occurs due to viral infections and postviral immune-mediated responses. (kjim.org)
- A viral infection can often cause inflammation of the heart muscles a condition called myocarditis which can lead to sudden heart attack and death. (smashwords.com)
- A viral infection usually causes myocarditis, but it can result from a reaction to a drug or be part of a more general inflammatory condition. (mayoclinic.org)
- Myocarditis is most often due to a viral infection . (wikipedia.org)
- Since myocarditis is often due to a viral illness, many patients give a history of symptoms consistent with a recent viral infection, including fever, rash, diarrhea , joint pains , and easily becoming tired. (wikipedia.org)
- In viral myocarditis, the Coxsackie B family of the single-stranded RNA viruses, in particular the plus-strand RNA virus Coxsackievirus B3 and Coxsackievirus B5 are the most frequent cause. (wikipedia.org)
- In children, the most common cause of myocarditis is a viral infection, such as influenza or the common cold. (seattlechildrens.org)
- Certain rare types of viral myocarditis, such as giant cell and eosinophilic myocarditis, respond to corticosteroids or other medications to suppress your immune system. (mayoclinic.org)
- For example, people with only mild viral myocarditis may be allowed to rest at home. (blogspot.com)
- When the cause of myocarditis is found, it's usually an infection that has made its way to the heart muscle, such as a viral infection (the most common) or a bacterial, parasitic, or fungal infection. (healthline.com)
- Clozapine-related myocarditis or acute viral myocarditis following a throat infection then was suspected, clozapine therapy was withdrawn, and the patient was transferred into the ICU. (redorbit.com)
- Trips to her pediatrician and the emergency room revealed she had likely contracted a form of myocarditis, an inflammation of the heart muscle usually caused by a viral infection, such as influenza. (clevelandclinic.org)
- I was concerned about a viral infection over a year ago and found that it is VERY difficult to find myocarditis specialists and the typical Dr response I heard was that viruses will work themselves out given time - while I consider that advice laughable it is often true - though many people do suffer from post viral fatigue, virally induced autoimmune problems, virally induced CFS etc etc. (medhelp.org)
- To our knowledge, this is the first study which demonstrates that TGF-β1 mRNA increases in viral-induced myocarditis at acute inflammatory phase. (nii.ac.jp)
- The outcome of viral myocarditis is closely associated with the immune response of the affected individual. (news-medical.net)
- This case reaffirms the possibility of cardiac involvement in CMV infection and emphasises the importance of viral aetiologies as differential diagnoses for acute myocarditis. (springer.com)
- However, in any viral epidemic only a very small % of victims are afflicted by clinically detectable myocarditis for an unknown reason (genetic predisposition? (brainscape.com)
- Death from myocarditis requires the presence of myocardial inflammation, without any other structural heart disease, and is frequently associated with a viral infection (1) . (onlinejacc.org)
- Are you sure your patient has viral myocarditis? (oncologynurseadvisor.com)
- Viral myocarditis may present subacutely, with symptoms of congestive heart failure, or it may present acutely, with hypotension and cardiac failure. (oncologynurseadvisor.com)
- The exclusion of other causes for heart failure and predominantly occur in patients with failure of viral clearance combination of symptoms, laboratory testing, ECG findings, leading to persistent inflammation or those that develop patho- and cardiac imaging leads to the diagnosis of myocarditis [3, genic cardiac autoantibodies directed against myocardial epi- (deepdyve.com)
- To date, treatment of myocarditis largely focuses tions are the most important causes of myocarditis with up to on supportive care to prevent heart failure or concomitant ad- 38% of the samples being positive for viral genomes [5- (deepdyve.com)
- As deleterious inflammatory responses to viral infections provoke myocardial dysfunction in myocarditis, therapies di- * Alexander Niessner rected towards immunomodulation have been assumed to be [email protected] beneficial. (deepdyve.com)
- In North America and Europe myocarditis is most often caused by viral infections. (escardio.org)
- The authors determined prospectively the diagnostic value of virus serology as compared to EMB and viral genome detection and immunohistochemistry in patients with clinically suspected myocarditis. (escardio.org)
- While there are several contributing factors that may lead to myocarditis, the primary cause is viral. (thefreedictionary.com)
- It is generally believed that viral infection is a major cause of myocarditis. (frontiersin.org)
- The pathophysiology of myocarditis consists of direct viral injury from viral proteins, the innate immune response including cytokines, toll-like receptors, and complements, and the acquired immune response involving T cells and antibodies. (frontiersin.org)
- Infectious myocardities are frequent, most of the time viral and can evolve to cardiac insufficiency. (bioportfolio.com)
- The article describes the etiology and potential clinical features of viral myocarditis in children and discusses its pathophysiology and critical care management. (ebscohost.com)
- Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis. (bvsalud.org)
- Left ventricular (LV) dysfunction in viral myocarditis is attributed to myocardial inflammation and fibrosis , inducing acute and long- time cardiac damage. (bvsalud.org)
- Early intervention with the MRA eplerenone modulates the acute host and defence reaction and prevents cardiac disease progression in experimental CVB3-induced myocarditis without aggravation of viral load . (bvsalud.org)
- The findings advocate for an initiation of therapy of viral myocarditis as early as possible, even before the onset of inflammation -induced myocardial dysfunction. (bvsalud.org)
- As a result, low replicative terminally deleted viral forms could be generated and selected in heart tissues during the early acute viral replication phase (myocarditis) and could establish an ongoing persistent human cardiac infection leading to chronic myocarditis and the DCM clinical phase. (thefreedictionary.com)
- Viral myocarditis is the most common form and is usually caused by coxsackieviruses, but a host of other agents have also been responsible. (health.am)
- Doolan A, Langlois N, Semsarian C (2004) Causes of sudden cardiac death in young Australians. (springer.com)
- Postmortem studies have identified myocarditis in up to 42% of cases of sudden cardiac death, suggesting a significant epidemiological impact. (auntminnieeurope.com)
- According to one study just 21% of 48 athletes who died of hypertrophic cardiomyopathy related sudden death had previous signs or symptoms of cardiac disease (chest pain, exertional dyspnea, syncope, dizziness) before death (Koester, 2001). (bartleby.com)
- How high are my chances of sudden cardiac death(real worry)? (medhelp.org)
- 2. Since your symptoms are not suggestive of an arrhythmia, the chances of sudden cardiac death and further complications does not arise. (medhelp.org)
- While not always life-threatening, in many cases it can lead to heart failure or sudden cardiac death. (healthcanal.com)
- By now, further testing revealed: Sophia had a form of the disease called fulminant myocarditis, which typically results in either sudden death or is self-resolving in a matter of days. (clevelandclinic.org)
- However, the potential catastrophic nature of a sudden cardiac death in the remote, but highly public, environment of space flight has led to continued concern since the early days of the space program over the possibility that space flight might be arrhythmogenic. (wikipedia.org)
- From a clinical perspective, according to the "biological model" of sudden cardiac death, both the substrate and the trigger for arrhythmias should be considered to determine whether long-term space flight could lead to an increased risk of sudden death. (wikipedia.org)
- Sudden, intense myocarditis can lead to heart failure . (medicalcityhospital.com)
- The term sudden cardiac death refers to natural death from cardiac causes, heralded by abrupt loss of consciousness within one hour of the onset of acute symptoms. (news-medical.net)
- Some heart disease patients face a higher risk of sudden cardiac death, which can happen when an arrhythmia -- an irregular heartbeat-- disrupts the normal electrical activity in the heart and causes the organ to stop pumping. (news-medical.net)
- Johns Hopkins researchers report that the level, or "copy number," of mitochondrial DNA--genetic information stored not in a cell's nucleus but in the body's energy-creating mitochondria--is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen. (news-medical.net)
- Other agencies have proposed a three-pronged On February 5, 2001, a 33-year-old male Fire strategy for reducing the risk of cardiac arrest and Fighter lost consciousness while he was exercising sudden cardiac death among fire fighters. (cdc.gov)
- in the day caused his sudden cardiac death (SCD). (cdc.gov)
- In the evening of October 24, 2005, a 47-year-old arrival they were met by personnel from another station male LT suffered a sudden cardiac death at his fi re who had already extinguished the fi re. (cdc.gov)
- To prove this hypothesis, we prospectively collected 3 cases of myocarditis-related sudden death (SD), according to the Dallas criteria (2) . (onlinejacc.org)
- To further investigate the genetic basis, we screened the most prevalent 55 sudden cardiac death-related genes (3) . (onlinejacc.org)
- Myocarditis is an important cause of sudden death in previously healthy adolescents. (oncologynurseadvisor.com)
- Determinants ECG changes to sudden cardiac death and acute deteriorating of progression from myocarditis to DCM remain unknown, but heart failure. (deepdyve.com)
- The latter is the cause of most sudden cardiac deaths that occur every year. (netdoctor.co.uk)
- Acute eosinophilic necrotizing myocarditis, another type of eosinophilic heart disease, is characterized by sudden onset, severe heart failure (of the ventricles), and high mortality. (readabstracts.com)
- This is different from drug-related hypersensitivity myocarditis, distinguished by a history of sensitivity to drugs, rapid pulse, and sudden and unexpected death from heart failure. (readabstracts.com)
- Drug therapy may be effective in treating endomyocarditis, but sudden acute necrotizing eosinophilic myocarditis is rare, rapid, and fatal. (readabstracts.com)
- With a wide range of symptoms from mild chest pain to severe arrhythmias or sudden cardiac death, myocarditis presents a clinical challenge. (escardio.org)
- In contrast to this type of mild appearance, myocarditis may also appear suddenly in the form of heart failure, or sudden cardiac death without any prior symptoms. (thefreedictionary.com)
- All children who underwent cardiac MRI (CMR) for evaluation of sudden acute chest pain with elevated troponins from April 2010 to May 2015 at our institution were included in the study and their findings were compared to age-matched controls with normal CMR. (biomedcentral.com)
- Sudden cardiac death -- Ch. 25. (epa.gov)
- Gastrointestinal infections (echoviruses), mononucleosis (Epstein-Barr virus) and German measles (rubella) also can cause myocarditis. (mayoclinic.org)
- Numerous bacteria can cause myocarditis, including staphylococcus, streptococcus, the bacterium that causes diphtheria and the tick-borne bacterium responsible for Lyme disease. (mayoclinic.org)
- and other fungi, such as histoplasma, often found in bird droppings, can sometimes cause myocarditis, particularly in people with weakened immune systems. (mayoclinic.org)
- Exposure to certain chemicals, such as carbon monoxide, and radiation can sometimes cause myocarditis. (mayoclinic.org)
- It is not clear why the same viruses cause myocarditis in some patients and different diseases - gastroenteritis, pneumonia, or hepatitis, for example - in others. (blogspot.com)
- The most common viruses to cause myocarditis include Coxsackievirus group B (an enterovirus), Human Herpes Virus 6, and Parvovirus B19 (which causes fifth disease ). (healthline.com)
- Yeast infections, molds, and other fungi can sometimes cause myocarditis. (healthline.com)
- They can also cause myocarditis. (healthline.com)
- Autoimmune diseases that cause inflammation in other parts of the body, like rheumatoid arthritis or SLE, can also sometimes cause myocarditis. (healthline.com)
- but toxins, drugs, and immunologic disorders can also cause myocarditis. (health.am)
- The potential for the HIV virus to cause myocarditis is now well recognized, though the prevalence of this complication is not known. (health.am)
- METHODS: Twenty-three consecutive white patients (38 ± 14 years, two women) discharged from our cardiac care unit with a diagnosis of acute myocarditis were evaluated retrospectively. (biomedsearch.com)
- STUDY OBJECTIVES: To explore the diagnostic performance of MRI for the diagnosis of acute myocarditis, using a comprehensive imaging approach. (biomedsearch.com)
- Endomyocardial biopsies have proven helpful with regard to the diagnosis of acute myocarditis superimposed on amyloidosis, in patients who present with conduction disorder and relatively preserved ventricular function, as was seen in this case. (elsevier.com)
- Nucifora, G, Gilbert, C & Selvanayagam, J 2016, ' Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging ', International Journal of Cardiology , vol. 223, pp. 881-882. (edu.au)
- A retrospective study: cardiac MRI of fulminant myocarditis in children-can we evaluate the short-term outcomes? (peerj.com)
- Wang H, Zhao B, Jia H, Gao F, Zhao J, Wang C. ( 2016 ) A retrospective study: cardiac MRI of fulminant myocarditis in children-can we evaluate the short-term outcomes? (peerj.com)
- Fulminant myocarditis (FM) is an inflammatory disease of the myocardium that results in ventricular systolic dysfunction and causes acute-onset heart failure. (peerj.com)
- The aim of our study was to assess the CMR findings at different course of FM and the short-term outcomes of fulminant myocarditis (FM) in children. (peerj.com)
- Some children with fulminant myocarditis develop progressive and fatal course and these patients should be supported by extracorporeal membrane oxygenation (ECMO) or ventricular assist devices (VAD) acutely. (medscape.com)
- Survival and left ventricular function changes in fulminant versus nonfulminant acute myocarditis. (springermedizin.de)
- We report a case of fulminant myocarditis after steroid pulse therapy for acute hepatitis. (nih.gov)
- Background The prognostic role of cardiac magnetic resonance (CMR) and late gadolinium enhancement (LGE) has not been clarified in acute myocarditis (AM) with preserved left ventricular (LV) ejection fraction (EF). (onlinejacc.org)
- The cardiac MR imaging protocol included T2-weighted imaging to assess edema and late gadolinium enhancement images acquired 10 minutes after weight-based administration of gadobutrol (Gadovist, Bayer HealthCare ) to detect necrosis. (auntminnieeurope.com)
- Quantitative changes in late gadolinium enhancement at cardiac magnetic resonance in the early phase of acute myocarditis. (springermedizin.de)
- If you have a mild case of myocarditis or are in the early stages, you might have no symptoms or mild ones, such as chest pain or shortness of breath. (mayoclinic.org)
- In serious cases, the signs and symptoms of myocarditis vary, depending on the cause of the disease. (mayoclinic.org)
- Contact your doctor if you have symptoms of myocarditis, particularly chest pain and shortness of breath. (mayoclinic.org)
- If you've had an infection, be alert for the symptoms of myocarditis and let your doctor know if they occur. (mayoclinic.org)
- Myocarditis is often associated with pericarditis , and many people with myocarditis present with signs and symptoms that suggest myocarditis and pericarditis at the same time. (wikipedia.org)
- Myocarditis treatment focuses on the cause and the symptoms, such as heart failure. (mayoclinic.org)
- In mild cases, myocarditis may have no noticeable symptoms. (blogspot.com)
- The best way to diagnose myocarditis may be through a person's observation of his or her own symptoms, followed by a thorough medical history and physical exam conducted by a doctor. (blogspot.com)
- Some patients may continue to have symptoms of moderate to severe CHF that may require eventual cardiac transplantation. (medscape.com)
- We have demonstrated that systematic workup of patients with angina-like symptoms, elevated troponin, and no significant coronary artery disease led to an almost fivefold increase in the diagnosis of myocarditis in our tertiary care center," wrote the researchers led by Dr. Bettina Heidecker of University Hospital Zurich. (auntminnieeurope.com)
- Before changing their strategy, the researchers only used cardiac MRI in patients with classic symptoms of myocarditis, which include chest pain, dyspnea, and palpitations. (auntminnieeurope.com)
- The authors hypothesized that systematic screening of patients presenting with angina-like symptoms, elevated troponin T, and no significant coronary artery disease using CMR will provide an approximation of the true incidence of myocarditis. (onlinejacc.org)
- Considering the potentially lethal adverse events of myocarditis if left untreated, we recommend a low threshold for the use of CMR in patients with angina-like symptoms and elevated TnT-hs after exclusion of coronary artery disease. (onlinejacc.org)
- The dangerous thing about myocarditis is that it can affect anyone, occur at any age, and may proceed without displaying any symptoms. (healthline.com)
- Though myocarditis can be difficult to diagnose, your doctor can use several tests to narrow down the source of your symptoms. (healthline.com)
- Clozapine withdrawal and targeted 8-day, low-dose corticosteroid therapy resolved the symptoms and restored cardiac function. (redorbit.com)
- I'm not sure what else might be the cause, or whether it's normal for myocarditis to have intermittent symptoms like this. (medhelp.org)
- Myocarditis can occur with no symptoms and remain undiagnosed. (medicalcityhospital.com)
- Some people have no symptoms of myocarditis. (medicalcityhospital.com)
- When respiratory symptoms are prominent, myocarditis may be misdiagnosed as pneumonia, bronchiolitis, or asthma. (oncologynurseadvisor.com)
- Symptoms of myocarditis may start as fatigue , shortness of breath, fever and aching of the joints, all characteristic of a flu-like illness. (thefreedictionary.com)
- A 57-year-old female was presented with chest pain and pre-syncope after flu-like symptoms, and was promptly diagnosed with acute myocarditis. (elsevier.com)
- In previously asymptomatic children, myocarditis can present with symptoms of acute chest pain suspicious for coronary ischemia. (biomedcentral.com)
- Early use of cardiac magnetic resonance reduces hospitalization time and costs in patients with acute myocarditis and preserved left ventricular function: a single center experience. (biomedsearch.com)
- Patients with signs of acute myocarditis (fever, WCC, flu-like illness and hemodynamic compromise) should be transferred to ICU, as ventricular support and oxygen support may become necessary. (smashwords.com)
- Steroid therapy is indicated in cardiac sarcoidosis in the presence of ventricular dysfunction and/or arrhythmia and in some forms of infection-negative eosinophilic or toxic myocarditis with heart failure and/or arrhythmia. (medscape.com)
- Pediatric ventricular assist devices (VADs) have been used as bridges to children with end-stage heart failure, including those resulting from myocarditis. (medscape.com)
- Heart attacks and infections (myocarditis) weaken the ventricular muscles leading to systolic dysfunction. (medindia.net)
- Objectives: Right ventricular (RV) myocarditis (MY) is unrecognized, and its prevalence is unknown. (unich.it)
- We evaluated the prevalence of RV involvement in acute MY and its association with cardiac events (cardiac death, cardiac arrest, ventricular assist device, transplantation, and appropriate ICD intervention). (unich.it)
- A cardiac mandatory regular medical evaluations and monitor showed ventricular fibrillation which was periodic physical examinations to determine unresponsive to several defibrillation attempts. (cdc.gov)
- Continuous medical education and training of physicians in these concepts is essential to avoid inappropriate interpretation of chronic mild elevations of cTn associated with, for example, heart failure or other structural cardiac disorders such as valvular heart disease and left ventricular hypertrophy as signs of MI. (medscape.com)
- Owing to the rare incidence of myo- tory treatment to prevent the development of cardiomyopathy carditis with severely impaired left ventricular function, this as a sequel of myocarditis were identified. (deepdyve.com)
- He had myocarditis causing left ventricular failure and acute respiratory distress syndrome. (springer.com)
- This is the first report of conduction system disturbances and slow ventricular tachycardia (VT), related to acute myocarditis associated with cardiac amyloidosis. (elsevier.com)
- Lim, HE, Pak, HN & Kim, YH 2006, ' Acute myocarditis associated with cardiac amyloidosis manifesting as transient complete atrioventricular block and slow ventricular tachycardia ', International Journal of Cardiology , vol. 109, no. 3, pp. 395-397. (elsevier.com)
- Mild myocardial dysfunction and subtle findings of edema or inflammation with evidence of progression to fibrosis suggest the presence of myocarditis. (onlinejacc.org)
- We propose that MHCII+Ly6Clo MDMs are associated with the reduction of cardiac fibrosis and prevention of the myocarditis sequalae. (listlabs.com)
- Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis. (clinicaltrials.gov)
- Overexpression of Interleukin-18 Aggravates Cardiac Fibrosis and Diastolic Dysfunction in Fructose-Fed Rats. (ebscohost.com)
- On the basis of the link between inflammation , fibrosis , aldosterone , and extracellular matrix regulation , we aimed to investigate the effect of an early intervention with the mineralocorticoid receptor antagonist (MRA) eplerenone on cardiac remodelling in a murine model of persistent coxsackievirus B3 (CVB3)-induced myocarditis . (bvsalud.org)
- These ameliorations were in vivo translated into prevention of cardiac fibrosis , as shown by 1.4-fold (P collagen content in the LV of eplerenone -treated vs. untreated CVB3-infected mice at Days 8 and 28, respectively. (bvsalud.org)
- Chronic myocarditis is characterized by degeneration of muscle tissue and fibrosis or infiltration of interstitial tissues. (thefreedictionary.com)
- Giant cell myocarditis must be distinguished from more common disorders that may contain giant cells, including sarcoidosis and hypersensitivity myocarditis. (ahajournals.org)
- Hypersensitivity myocarditis is a rare form of myocarditis. (kjim.org)
- Here, we report a case of hypersensitivity myocarditis that was probably triggered by amoxicillin and that resolved completely with heart failure management as well as discontinuation of the drug. (kjim.org)
- Among these, hypersensitivity myocarditis is very rare, and its true incidence is unknown. (kjim.org)
- 1 ] reported that seven explanted hearts from 288 heart transplants (2.4%) had histological evidence of hypersensitivity myocarditis. (kjim.org)
- Unlike other forms of myocarditis, the prognosis of hypersensitivity myocarditis is excellent, usually improving after administration of the causative drug is ceased. (kjim.org)
- Thus, suspicion of hypersensitivity myocarditis is important. (kjim.org)
- Pediatric Life-Threatening Coronavirus Disease 2019 With Myocarditis. (cdc.gov)
- July 11, 2019 -- Myocarditis remains underdiagnosed, and lowering the threshold for diagnostic workup with cardiac MRI can help to identify myocarditis early, leading to significant improvements in patient care, according to a joint Swiss-German study published on 3 July in Swiss Medical Weekly . (auntminnieeurope.com)
- The utility of cardiac magnetic resonance imaging (MRI) as a screening tool for myocarditis in competitive student athletes returning to training after recovering from coronavirus disease 2019 (COVID-19) infection is unknown. (cdc.gov)
- Abstract 1927: Role of Cardiac Magnetic Resonance Imaging in Patients with Myocarditis: Does late Enhancement have Prognostic Value? (ahajournals.org)
- abstract = "There is a growing consensus to recognize the role of cardiac magnetic resonance (MR) imaging in the diagnosis of myocarditis. (elsevier.com)
- Most patients affected with myocarditis remain asymptomatic and the disease is spontaneously resolved 2 . (jove.com)
- The disease can be induced in myocarditis-susceptible A/J and Balb/c mice by immunizing the animals with cardiac myosin heavy chain (Myhc)-α or its immunodominant peptide fragments or by infecting with pathogens like coxsackievirus B3 4-9 . (jove.com)
- Myocarditis is a common cardiac disease. (onlinejacc.org)
- Chagas' disease in cardiac muscle of a patient with chronic myocarditis. (gettyimages.es)
- In the active phase of the disease, the giant cells are typically located immediately adjacent to necrotic cardiac myocytes. (ahajournals.org)
- Myocarditis is also caused due to Chagas disease, an infectious illness that is transmitted by insects. (blogspot.com)
- Treatment of the specific causes of the myocarditis (ie, bacterial sepsis, rickettsial disease) is necessary. (medscape.com)
- Consider immunosuppression in proven autoimmune (eg, infection-negative) forms of myocarditis, without immunosuppression contraindications (eg, giant cell myocarditis, cardiac sarcoidosis, myocarditis associated with known extracardiac autoimmune disease). (medscape.com)
- How does a coronary heart disease affect the cardiac muscle? (healthtap.com)
- By redesigning their approach to use cardiac MRI to examine all unexplained cases of myocardial infarction and nonobstructive coronary artery disease, and by implementing key MR imaging protocols during the scans, researchers were able to significantly increase the detection rate of myocarditis from 12.7 per 100,000 hospitalizations between 2011 and 2015 to 62.5 per 100,000 hospitalizations between 2016 and 2017. (auntminnieeurope.com)
- Beginning in 2016, cardiac MRI was used for all unexplained cases of myocardial infarction and nonobstructive coronary artery disease, based on guidelines from the European Society of Cardiology (ESC). (auntminnieeurope.com)
- CKD patients with advanced disease have misfortune of having both a dramatically high rate of cardiac mortality paired with decreased ability to detect, it due to elevated Cardiac Troponin levels. (bartleby.com)
- Kawasaki disease may also be associated with myocarditis. (oncologynurseadvisor.com)
- Myocarditis may present like congestive heart failure due to other causes- including congenital malformations of the heart, valvular disease, cardiac ischemia, and Kawasaki disease. (oncologynurseadvisor.com)
- Each section presents a structured review of the theory and practice of cardiac imaging, while detailing the application of different modalities in diagnosing cardiovascular disease. (powells.com)
- Although the inflammation or degeneration of the heart muscle that myocarditis causes may be fatal, this disease often goes undetected. (thefreedictionary.com)
- Approach to cardiac disease diagnosis -- Ch. 2. (epa.gov)
- Myocarditis, the inflammation of the heart muscle, could be in some cases serious and potentially fatal disease. (e-booksdirectory.com)
- Offering comprehensive coverage of CMR and the latest cardiology applications, this practical reference enhances the understanding of cardiac physiology and the interpretation and diagnosis of cardiovascular disease. (weltbild.de)
- My disease was cardiac insufficiency caused by acute myocarditis which is inflammation in the heart from high fever. (christiantelegraph.com)
- Histologic examination of the explanted heart otherwise showed the usual severe chronic myocarditis characteristic of this disease (Figure, 1A), most extensively involving the left ventricle. (thefreedictionary.com)
- While cardiac MRI is one option to diagnose the condition, the "true incidence of myocarditis remains unknown," the researchers noted. (auntminnieeurope.com)
- Objectives This study sought to obtain an approximation of the true incidence of myocarditis by systematic screening of patients at risk using cardiac magnetic resonance imaging (CMR) in a tertiary care center. (onlinejacc.org)
- Conclusions A novel diagnostic screening algorithm led to a 6.3-fold increase of the incidence of myocarditis in our hospital. (onlinejacc.org)
- The exact incidence of myocarditis in children remains unknown ( 1 ). (frontiersin.org)
- We found that in addition to cardiomyocytes cardiac fibroblasts were infected by CVB3 and displayed a higher virus replication (132-fold increase) compared to cardiomyocytes (14-fold increase) between 6 and 24 hours after infection. (hindawi.com)
- One of the most common causes for acute myocarditis is a cardiac infection with viruses, especially with enteroviruses of the Coxsackievirus B family [ 1 , 6 , 7 ]. (hindawi.com)
- Myocarditis is acute or chronic inflammation of the heart muscle due to reaction of living tissue to injury or infection. (smashwords.com)
- Blood tests can also detect antibodies against viruses and other organisms that might indicate a myocarditis-related infection. (mayoclinic.org)
- Rest and medication to help your body fight off the infection causing myocarditis might be all you need. (mayoclinic.org)
- Acute myocardial damage similar to that seen in human myocarditis occurs in BALB/c mice after infection with coxsackievirus B3 (CB3) or encephalomyocarditis virus (EMC). (ahajournals.org)
- Myocarditis can also result from infection with Staphylococcus aureus or Corynebacterium diptheriae . (healthline.com)
- We report a case of myocarditis and cardiac insufficiency due to primary CMV infection. (springer.com)
- We describe a previously healthy man who developed myocarditis and cardiac insufficiency due to primary CMV infection. (springer.com)
- Recent reports have linked human herpesvirus 6 (HHV-6) infection, typically a benign infection in childhood, with myocarditis. (nih.gov)
- These cases suggest that HHV-6 infection should be considered as an etiology of myocarditis in immunosuppressed patients regardless of correlating blood levels. (nih.gov)
- Various animal models have been developed to study the immune pathogenesis of myocarditis. (jove.com)
- These results indicate that immature but antigen-specific T cells play a role in the pathogenesis of ongoing myocarditis. (ahajournals.org)
- Most viruses involved in the pathogenesis of myocarditis are also prevalent in the population and these facts complicate the interpretation of serological results. (escardio.org)
- An approach used only with a patient's consent, this procedure may also confirm acute myocarditis, allowing close monitoring of potential congestive heart failure. (blogspot.com)
- Myocarditis should be considered in the differential diagnosis of all children who present with unexplained congestive heart failure. (oncologynurseadvisor.com)
- DESIGN AND SETTINGS: Twenty patients with myocarditis and 7 age-matched and gender-matched control subjects underwent comprehensive MRI. (biomedsearch.com)
- In this case series, an electronic health record search was performed at our institution (University of Wisconsin) to identify all competitive athletes (a consecutive sample) recovering from COVID-19, who underwent gadolinium-enhanced cardiac MRI between January 1, 2020, and November 29, 2020. (cdc.gov)
- Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and its prevalence is projected to rise continuously over the next few decades because of an aging population. (news-medical.net)
- Human immunodeficiency virus (HIV) is also now recognized as a cause of myocarditis, though its prevalence is not known. (thefreedictionary.com)
- It is estimated that the prevalence of pediatric myocarditis is 0.3 cases per year per 100,000 children ( 6 ). (frontiersin.org)
- To describe the prevalence and severity of cardiac MRI findings of myocarditis in a population of competitive student athletes recovering from COVID-19. (cdc.gov)
- Heart failure is the leading cause of deaths, and myocarditis is one predominant cause of heart failure in young adolescents 1 . (jove.com)
- Cardiac catheterization and angiography are additional diagnostic tests used to determine the presence of myocarditis, or to rule out other possible heart diseases that may lead to heart failure. (blogspot.com)
- Myocardial expression of the anaphylatoxin receptor C3aR is associated with cardiac inflammation and prognosis in patients with non-ischaemic heart failure . (nih.gov)
- The Heart Failure Society of America does not recommend routine use of immunosuppressive therapies for patients with myocarditis. (medscape.com)
- What is the difference between a heart attack, heart failure and cardiac arrest? (healthtap.com)
- Diphtheritic myocarditis is caused by the exotoxin and often is manifested by conduction abnormalities as well as heart failure. (health.am)
- Toxoplasmosis causes myocarditis that is usually asymptomatic but can lead to heart failure. (health.am)
- Small steps for idiopathic giant cell myocarditis. (springermedizin.at)
- Shabetai R. Idiopathic giant-cell myocarditis-natural history and treatment. (springermedizin.at)
- This is called idiopathic myocarditis. (medicalcityhospital.com)
- Giant cell myocarditis is a rare idiopathic disorder characterized by giant cell and lymphocyte infiltration of the heart muscle. (health.am)