Dictionaries, MedicalCardenolides: C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone at C-17. They are aglycone constituents of CARDIAC GLYCOSIDES and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include DIGITOXIN and DIGOXIN and their derivatives and the STROPHANTHINS.Apocynaceae: The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Nerium: A plant genus of the family APOCYNACEAE. It is a very poisonous plant that contains cardioactive agents.Strophanthus: A plant genus of the family APOCYNACEAE that contains OUABAIN cardiac glycosides.Methomyl: A carbamate insecticide with anticholinesterase activity.Digitalis: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.Asclepias: A plant genus of the family ASCLEPIADACEAE. This is the true milkweed; APOCYNUM & EUPHORBIA hirta are rarely called milkweed. Asclepias asthmatica has been changed to TYLOPHORA.Calotropis: A plant genus of the family ASCLEPIADACEAE. The downy akund floss fiber from the seeds is used like kapok.Digitoxigenin: 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide. A cardenolide which is the aglycon of digitoxin. Synonyms: Cerberigenin; Echujetin; Evonogenin; Thevetigenin.Thevetia: A plant genus of the family APOCYNACEAE. Members contain thevetin.GlucosidesCardiac Glycosides: Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Celastraceae: A plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.Cordia: A plant genus of the family BORAGINACEAE. Members contain TRITERPENES and naphthoxirene.Pregnanes: Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.Rhizome: Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.Liliaceae: A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.Saponins: A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.Spirostans: Cholestane derivatives containing a fused lactone ring at the 16,17-position and a spiroglycosidic linkage at C-22. Members include sarsaponin, DIOSGENIN and yamogenin.Hosta: A plant genus of the family LILIACEAE. Members contain steroidal saponins.Beetles: INSECTS of the order Coleoptera, containing over 350,000 species in 150 families. They possess hard bodies and their mouthparts are adapted for chewing.Butterflies: Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Pyrrolizidine Alkaloids: A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.Animal Migration: Periodic movements of animals in response to seasonal changes or reproductive instinct. Hormonal changes are the trigger in at least some animals. Most migrations are made for reasons of climatic change, feeding, or breeding.Moths: Insects of the suborder Heterocera of the order LEPIDOPTERA.Ricin: A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.

A probable relationship between an endogenous digitalis-like substance and concentric cardiac hypertrophy in primary aldosteronism. (1/165)

A 44-year-old woman was admitted to our hospital due to severe hypertension. An electrocardiogram (ECG) and an echocardiogram showed severe left ventricular hypertrophy. Her plasma aldosterone level was elevated. Magnetic resonance imaging revealed a small mass in the right adrenal gland. Before removal of the tumor, plasma endogenous digitalis-like substance (EDLS) levels were elevated. After removal of the tumor, EDLS levels quickly returned to the normal level. A series of echocardiograms and ECGs over a 6- year period after removal of the tumor showed marked regression of cardiac hypertrophy. These findings suggest that EDLS may be closely related to the development of concentric cardiac hypertrophy in primary aldosteronism.  (+info)

Increases in plasma ouabainlike immunoreactivity during surgical extirpation of pheochromocytoma. (2/165)

The ouabainlike factor (OLF) is thought to be an important modulator of salt and water metabolism. Plasma OLF could be derived from the central nervous system and/or the adrenal gland. Since the adrenal medulla is of neural origin, the cytology of pheochromocytoma of adrenomedullary origin resembles that of neuronal cells. Ouabainlike immunoreactivity (OLI) is, in fact, present in the adrenal medulla as shown by immunohistochemistry. The plasma levels of catecholamines and OLI were significantly elevated during surgical extirpation of pheochromocytoma in this case. To clarify the origin of circulating OLI in a patient with pheochromocytoma, the relationship between plasma OLI and catecholamines during adrenalectomy was investigated. Plasma catecholamine levels exceeded the normal reference interval, and plasma OLI was positively correlated with the patient's plasma level of norepinephrine. The peak level during operation was about 10 times higher than the baseline level. Both levels reached a maximum when the tumor was mechanically pressed, and then gradually decreased thereafter. The level of OLI in the tumor was higher than that of the normal adrenal cortex. When OLI in the tumor was characterized by reversed-phase high-performance liquid chromatography, the retention time of OLI corresponded with that of authentic ouabain. These results suggest that the circulating OLI in this patients was derived mainly from the pheochromocytoma of adrenomedullary origin.  (+info)

Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction. (3/165)

In chronic heart failure (CHF), sympathetic activity increases in parallel with the impairment of left ventricle (LV) function, and sympathetic hyperactivity has been postulated to contribute to the progression of heart failure. In the brain, compounds with ouabain-like activity ("ouabain," for brevity) and the renin-angiotensin system contribute to sympathetic hyperactivity in rats with CHF after myocardial infarction (MI). In the present studies, we assessed whether, in rats, chronic blockade of brain "ouabain" or the brain renin-angiotensin system inhibits the post-MI LV dysfunction. In rats, an MI was induced by acute coronary artery ligation. At either 0.5 or 4 wk post-MI, chronic treatment with Fab fragments for blocking brain "ouabain" or with losartan for blocking brain AT(1) receptors was started and continued until 8 wk post-MI using osmotic minipumps connected to intracerebroventricular cannulas. At 8 wk post-MI, in conscious rats, LV pressures were measured at rest and in response to volume and pressure overload, followed by LV passive pressure-volume curves in vitro. At 8 wk post-MI, control MI rats exhibited clear increases in LV end-diastolic pressure (LVEDP) at rest and in response to pressure and volume overload. LV pressure-volume curves in vitro showed a marked shift to the right. Intravenous administration of the Fab fragments or losartan at rates used for central blockade did not affect these parameters. In contrast, chronic central blockade with either Fab fragments or losartan significantly lowered LVEDP at rest (only in 0.5- to 8-wk groups) and particularly in response to pressure or volume overload. LV dilation, as assessed from LV pressure-volume curves, was also significantly inhibited. These results indicate that chronic blockade of brain "ouabain" or brain AT(1) receptors substantially inhibits development of LV dilation and dysfunction in rats post-MI.  (+info)

Sodium pump inhibition and regional expression of sodium pump alpha-isoforms in lens. (4/165)

Both hypertension and cataract formation have been associated with reductions in sodium pump activity, possibly as a result of an endogenous inhibitor. The objective of the present study was to answer 4 closely related questions: (1) Is the lens sodium pump effectively inhibited by a labile, digitalis-like factor we have identified in the peritoneal dialysate from hypertensive patients in end-stage renal failure? (2) How does that inhibition compare to that induced by ouabain? (3) Does sodium pump isoform distribution determine the degree of lens sodium pump inhibition? (This question was precipitated by the unanticipated finding that the labile DLF was more effective in inhibiting lens sodium pump than was anticipated.) (4) Is sodium pump activity altered in lens in response to increased salt intake, a maneuver known to increase endogenous digitalis-like factor? We found that whereas ouabain produced equivalent or significantly less inhibition of lens Na(+), K(+)-ATPase from calf or rabbit, respectively, compared with brain, labile digitalis-like factor preferentially inhibited lens compared with brain. Analysis of whole-lens preparations from rabbit, calf, and normal human lens revealed substantial alpha2- and alpha3-isoforms of the sodium pump but little alpha1-isoform. Ouabain inhibition of whole-lens Na(+),K(+)-ATPase from rabbit and calf were comparable: for rabbit lens, K(i)=5.2x10(-7) mol/L; for calf lens, K(i)=1.0x10(-6) mol/L. Limited quantities of labile digitalis-like factor prohibited similar determinations; however, its concentration-activity profile paralleled that of ouabain. Na(+), K(+)-ATPase activity, measured in the 3 major anatomic regions of lens and normalized to nucleus, was greatest in epithelium (56. 9+/-17.9) compared with cortex (5.8+/-1.4) and nucleus (1.0+/-0.0; P=0.01). Immunohistochemistry of rabbit lens found abundant alpha2- and alpha3-isoforms in epithelium and limited alpha3 but undetectable alpha1 in cortex and nucleus. Finally, rats randomized to a high Na diet showed significantly reduced lens Na(+), K(+)-ATPase activity compared with those on a low Na diet, consistent with the effects of a sodium pump inhibitor. In conclusion, the present study suggests that digitalis-like factor may provide a link between hypertension and cataract formation.  (+info)

Recent aspects in the genetic renal mechanisms involved in hypertension. (5/165)

The kidney plays an important role in the blood pressure regulation primarily by modulating tubular sodium reabsorption. Various hormones, vasoactive peptides, autacoids and transporters or channels in renal tubules are involved in this process. Genes associated with renal tubular sodium handling are possibly related to the development of hypertension. Genes of the renin-angiotensin-aldosterone system are thought to be especially important as causal genes of hypertension. Na-K-ATPase, biochemically equal to Na pump, exists on the basolateral membrane of renal epithelial cells. It plays a central role in Na reabsorption and creates a driving force for transepithelial transport. Na-K-ATPase activity is regulated by adducin, a membrane-bound skeletal protein, as well as by several hormones such as dopamine, endogenous ouabain-like factor or cytochrome P450 metabolites. Genes of these factors involved in Na-K-ATPase regulation should be related to the development of hypertension. The endothelin system, atrial natriuretic peptide and nitric oxide regulate the tonus of blood vessels as well as renal sodium excretion. Several reports have indicated that genes of these substances are crucial in the pathogenesis of hypertension.  (+info)

Increased digitalis-like immunoreactive substances in patients with hypertrophic cardiomyopathy. (6/165)

AIMS: Although increased digitalis-like immunoreactive substances have been found in cases of hypertension and heart failure, no information is available about digitalis-like immunoreactive substances in patients with hypertrophic cardiomyopathy. We investigated digitalis-like immunoreactive substances in the plasma and biopsied specimens of patients with hypertrophic cardiomyopathy. METHODS AND RESULTS: In 40 patients with hypertrophic cardiomyopathy (27 with the non-obstructive type and 13 with the obstructive type), the plasma concentration of digitalis-like immunoreactive substances was studied by fluorescence polarization immunoassay. Right ventricular endomyocardial biopsy specimens were analysed immunohistochemically, using a monoclonal antibody against digoxin. An increase in digitalis-like immunoreactive substances of more than 0.2 ng. ml(-1)in plasma was found in six of 27 patients with non-obstructive hypertrophic cardiomyopathy (22.2%) and five of 13 with obstructive hypertrophic cardiomyopathy (38.4%). Under light microscopy, positive staining against the antibody was observed heterogeneously on some cardiocytes. In non-obstructive hypertrophic cardiomyopathy, digitalis-like immunoreactive substances in the plasma correlated with the left atrial dimension and inversely with the cardiac index. In obstructive hypertrophic cardiomyopathy, plasma and myocardial digitalis-like immunoreactive substances were positively correlated; they also correlated with left ventricular end-diastolic pressures. Under electron microscopy, digitalis-like immunoreactive substances were detected at the sarcolemma in the free wall, T-tubules, intercalated discs and Z-bands of cardiocytes. CONCLUSIONS: Increased digitalis-like immunoreactive substances in plasma and cardiocytes, which may have been caused by pressure and/or volume overload, were found in patients with hypertrophic cardiomyopathy. Digitalis-like immunoreactive substances may act on the sarcolemma of cardiocytes and be transported into the cytoplasm.  (+info)

Interleukin-13 prevents diaphragm muscle deterioration in a septic animal model. (7/165)

The effects of an intravenous injection of Interleukin-13 (IL-13) after endotoxin administration on diaphragm muscle were studied using Wistar rats. Two treatment groups, a control (saline+endotoxin) group and an IL-13 (IL-13+endotoxin) group were studied. E. coli endotoxin (10 mg/kg) was injected intraperitoneally 5 minutes after saline or IL-13 (0.25 microg) injection. The force-frequency curves, twitch kinetics and fatigability were measured at 0 and 4 hours after endotoxin injection. The force-frequency curves and twitch tension in the control group were significantly lower at 4 hours than those at 0 hour due to endotoxin. On the other hand, IL-13 prevented the decrement of the force-frequency curves and twitch tension induced by endotoxin. Nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase histochemistry showed positive staining at 4 hours due to endotoxin in the control group; however, IL-13 also blocked NADPH diaphorase staining at 4 hours. Furthermore, the positive muscle fibers detected by the NADPH diaphorase staining were classified as type I (slow twitch) muscle fibers by ATPase staining. We conclude that IL-13 prevents the deterioration of contraction induced by endotoxin by inhibiting nitric oxide production in the diaphragm muscle, mainly the type I muscle fibers.  (+info)

Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. (8/165)

Cardiac glycosides are used clinically to increase contractile force in patients with cardiac disorders. Their mechanism of action is well established and involves inhibition of the plasma membrane Na+/K+-ATPase, leading to alterations in intracellular K+ and Ca(2+) levels. Here, we report that the cardiac glycosides oleandrin, ouabain, and digoxin induce apoptosis in androgen-independent human prostate cancer cell lines in vitro. Cell death was associated with early release of cytochrome c from mitochondria, followed by proteolytic processing of caspases 8 and 3. Oleandrin also promoted caspase activation, detected by cleavage poly(ADP-ribose) polymerase and hydrolysis of a peptide substrate (DEVD-pNA). Comparison of the rates of apoptosis in poorly metastatic PC3 M-Pro4 and highly metastatic PC3 M-LN4 subclones demonstrated that cell death was delayed in the latter because of a delay in mitochondrial cytochrome c release. Single-cell imaging of intracellular Ca(2+) fluxes demonstrated that the proapoptotic effects of the cardiac glycosides were linked to their abilities to induce sustained Ca(2+) increases in the cells. Our results define a novel activity for cardiac glycosides that could prove relevant to the treatment of metastatic prostate cancer.  (+info)

*Cardenolide

... is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the ... The cardenolide content in butterflies deters most vertebrate predators, except a few which have evolved to become cardenolide- ... form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are ... Species such as the monarch, queen, and plain tiger ingest the cardenolides contained in the milkweeds (Asclepias) that they ...

*Asclepias

Milkweed is named for its milky sap, which consists of a latex containing cardiac glycosides termed cardenolides. Most species ... Milkweeds use three primary defenses to limit damage caused by caterpillars: hairs on the leaves, cardenolide toxins, and latex ... Singh, B. and Rastogi, R.P. (1970). Cardenolides-glycosides and genins. Phytochemistry 9: 315-331. Agrawal, Anurag (2017-03-07 ... "Toxic cardenolides: chemical ecology and coevolution of specialized plant-herbivore interactions". New Phytologist. 194 (1): 28 ...

*Asclepias curassavica

Cardenolides-glycosides and genins. Phytochemistry 9: 315-331. Singh, B. and Rastogi, R.P. 1972. Structure of ascelpin and some ...

*Digitoxigenin

... , a cardenolide, is the aglycone of digitoxin. Digitoxigenin can be used to prepare actodigin. In Lednicer's book ... "Synthetic Cardenolides and Related Products. III. Isocardenolides". Canadian Journal of Chemistry. 52 (9): 1652-1661. doi: ...

*Neoconvalloside

... is a cardenolide glycoside extracted from Convallaria majalis. Viqar Uddin Ahmad & Anwer Basha (2006). ... ISBN 978-0-387-31162-3. Komissarenko, N. F.; Stupakova, E. P. (1986). "Neoconvalloside - a cardenolide glycoside from plants of ... Spectroscopic Data of Steroid Glycosides: Cardenolides and Pregnanes. 4. doi:10.1007/978-0-387-39576-0_386. ...

*Digitalis grandiflora

As the plant contains cardenolides, all parts are toxic. Its leaves contain 0.2% glycosides of the digitoxin-type and about 0,1 ...

*Ornithogalum

The bulbs contain alkaloids and cardenolides, which are toxic. Ornithogalum has been listed as one of the 38 plants used to ...

*Black-eared mouse

1992). "Effectiveness of cardenolides as feeding deterrents to Peromyscus mice". Journal of Chemical Ecology. 18 (9): 1559-1575 ... Unusually, they are able to tolerate very bitter cardenolide chemicals, allowing them to consume relatively large quantities of ...

*Cycnia tenera

It is a common feeder on Apocynum cannabinum (dogbane, Indian hemp) which produces a milky latex containing cardenolides, toxic ... Cycnia tenera tenera Cycnia tenera sciurus (Boisduval, 1869) James A. Cohen & Lincoln P. Brower (1983). "Cardenolide ...

*PROPHET system

"Functional receptor mapping for modified cardenolides: Use of the PROPHET system." 1979. 259-279. Weeks, Charles M., et al. " ...

*Arctiinae (moth)

... or cardenolides), pyrrolizidine alkaloids, pyrazines and histamines. Larvae usually acquire these chemicals, and may retain ...

*Cascabela thevetia

These cardenolides are not destroyed by drying or heating and they are very similar to digoxin from Digitalis purpurea. They ... The main toxins are the cardenolides called thevetin A and thevetin B; others include peruvoside, neriifolin, thevetoxin and ...

*3beta-hydroxy-5beta-steroid dehydrogenase

Stuhlemmer U; Kreis W (1996). "Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, ... Seitz HU; Gaertner DE (1994). "Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea". Plant Cell. 38: 337- ...

*Danaus chrysippus

The ability of D. chrysippus to store cardenolides varies across populations, so likely both cardenolides and pyrrolizidine ... Brower, Lincoln P.; Gibson, D. O.; Moffitt, C. M.; Panchen, A. L. (1978-06-01). "Cardenolide content of Danaus chrysippus ... Previously, it was thought that cardenolides obtained from food sources during the larval stage were responsible for the ... Milkweed contains toxic compounds, cardenolides, which are often consumed and stored by many butterflies. Because of their ...

*Cerberin

... , with its five-membered ring, belongs to the cardenolide class;[subscription required] cardenolides are 23-carbon ... Cheenpracha S., Karalai C., Rat-A-Pa Y., Ponglimanont C. & Chantrapromma K., 2004, "New cytotoxic cardenolide glycoside from ... The cardenolide substructure to which the sugar is attached has also been independently characterised, and can be referred to ... Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65, 507-510. Robert A. Newman, Peiying Yang, ...

*Asclepias curtissii

The sap of Asclepias curtissii contains cardenolides which are toxic to vertebrates in high quantities. Despite this deer are ...

*K-Strophanthidin

... is a cardenolide found in species of the genus Strophanthus. It is the aglycone of k-strophanthin, an analogue ... Fricke U, Klaus W (1981). "The influence of reduced serum potassium level on the toxicity of some cardenolides in guinea pigs ...

*Mukaiyama hydration

A Bioactive Cardenolide". Science. 339 (6115): 59-63. Bibcode:2013Sci...339...59R. doi:10.1126/science.1230631. ISSN 0036-8075 ...

*Southern fiscal

Brower, Lincoln P.; Gibson, D. O.; Moffitt, C. M.; Panchen, A. L. (1978-06-01). "Cardenolide content of Danaus chrysippus ...

*Norrish reaction

A Bioactive Cardenolide". Science. 339 (6115): 59-63. Bibcode:2013Sci...339...59R. doi:10.1126/science.1230631. PMC 4365795 . ... synthetically useful Norrish type II reaction can be found early in the total synthesis of the biologically active cardenolide ...

*Scilloideae

Many Scilloideae produce poisonous steroidal saponins such as bufadienolides and cardenolides, making them inedible.[citation ...

*Queen (butterfly)

It was shown that queens reared on the high-cardenolide A. curassavica sequester and store levels of cardenolides similar to ... However, queens reared on S. clausum, a larval host plant known to be a very poor cardenolide source, contain no detectable ... Most of the toxic cardenolides that make queens so unpalatable to its predators are sequestered from larval host plants. For ... Unpalatability is correlated with the level of cardenolides obtained via the larval diet, but other compounds like alkaloids ...

*Bufadienolide

Cardenolides at the US National Library of Medicine Medical Subject Headings (MeSH). ... the other being the cardenolide glycosides. Both bufadienolides and their glycosides are toxic; specifically, they can cause an ... Proscillaridin Daigremontianin Cardenolides Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German ...

*Strophanthin

The singular may refer to : g-Strophanthin, also known as ouabain k-Strophanthin Cardenolide. ...

*Digitalis thapsi

In studies, the restriction of calcium ions resulted in cardenolide accumulation in D. thapsi. Calcium quantity affects the ... 1 October 1991). "Effect of calcium, manganese and lithium on growth and cardenolide content in cell suspension cultures of ... 1995). "Calcium restriction induces cardenolide accumulation in cell suspension cultures of Digitalis thapsi L". Plant Cell ... "Relationship between active oxygen species and cardenolide production in cell cultures of Digitalis thapsi: effect of calcium ...
1. Endogenous digoxin-like immunoreactivity (EDLI) was measured by radioimmunoassay for digoxin in 13 paired samples of arterial and venous umbilical cord serum. EDLI was present in vein and artery, but was higher in the venous samples (P , 0.025).. 2. The venous cord serum inhibited the ouabain-sensitive sodium efflux rate constant of a normal mixed leucocyte population when compared with the effect of arterial cord serum (P , 0.005).. 3. It is suggested that the placenta may be involved in the production or metabolism of neonatal EDLI and of the inhibitor of sodium transport. ...
Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are often toxic; specifically, they are heart-arresting. The term derives card- "heart" (from Greek καρδία kardiā) and the suffix -enolide, referring to the lactone ring at C17. It should not be confused with cardanolides. Cardanolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype of this class (see MeSH D codes list). Cardenolides are C(23)-steroids with methyl groups at C-10 and C-13 and a five-membered lactone (specifically a butenolide) at C-17. They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes cardadienolides and cardatrienolides. Members include: acetyldigitoxins acetyldigoxins cymarine digitoxin ...
TY - JOUR. T1 - A digoxin-like factor associates with erythrocyte sodium concentration, sodium transport, and ouabain binding. AU - Hunt, Steven. AU - Wu, Lily L.. AU - Stults, Barry M.. AU - Williams, Roger R.. PY - 1988. Y1 - 1988. N2 - To investigate what effects a circulating digoxin-like factor (DLF) might have on sodium metabolism, we examined data collected on 1,327 individuals screened in the Cardiovascular Genetics Clinic at the University of Utah. This sample included 639 unmedicated adults, 582 youths under age 18, and 106 medicated hypertensive individuals, all on an unrestricted diet when attending clinic. No individuals took digitalis. A digoxin assay detected measurable levels of plasma DLF in 13.4% of the youths, 17.2% of the normotensive adults, and 25.5% of the hypertensive adults. In all three groups of individuals, those with a measurable DLF had a significantly lower erythrocyte ouabain sensitive sodium efflux rate constant (adjusted for age, sex and body mass) than those ...
Recent studies have pointed to the existence of an endogenous digoxin-like immuno-active factor (DLIF), which may be associated with hypertension and pre-eclampsia. The DLIF levels in the umbilical venous and umbilical arterial blood of neonates, as well as the maternal serum of primigravidas and multigravidas with and without pre-eclampsia, were determined by means of a commercially available radioimmunoassay kit, which is cross-reactive with DLIF, in 44 mothers and their babies in search for a possible placental, fetal or maternal origin of the DLIF. The mean placental and neonatal masses were significantly lower in the pre-eclampsia group than in the control group (P , 0,01). However, the DLIF levels in the maternal serum, umbilical cord venous and umbilical cord arterial serum were statistically significantly higher in the pre-eclampsia group than in the control pregnant group (P , 0,05). A very strong correlation was found between umbulical cord venous and arterial DLIF levels (r = 0,90; P ...
Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive ...
Knowledge of the details of migration is relatively recent. Their lifecycle was proven by chemical analysis of their cardenolides, the toxic substance the larvae acquire from feeding on milkweed. There are differences in the "chemical fingerprint" of the cardenolides. Studies showed that the chemical found in wintering butterflies and those first heading north from Mexico was distinctive, produced only in milkweed plants from the Northern US and Canada. Their wintering grounds werent even discovered until 1975 ...
Exposure of PC-3 cells to UNBS5162 (1 µM for 5 successive days) dramatically decreases the expression of the proangiogenic CXCL chemokines. UNBS5162 displays weak in vitro antiproliferative activity with IC50 values of 17.3 μM, 16 μM, 4.7 μM, 8.5 μM, 28.8 μM, 8.9 μM, 46.5 μM, 21.2 μM, 9.1 μM in PC-3, DU-145, U373-MG, Hs683, HCT-15, LoVo, MCF-7, A549 and Bx-PC-3 cells. At 10 µM UNBS5162 markedly impairs PC-3 tumor cell growth kinetics, without inducing senescence, whereas the reverse feature is observed with respect to DU-145 cells. This difference might result from their respective p53 status and/or the extent of p16 expression. At 1 µM, UNBS5162 induces no such antitumor effects. UNBS5162 at 10 µM markedly increased the levels of heterochromatin in PC-3 cells through an increase in number of histones, at least at the mRNA levels[1]. UNBS5162 has been identified to decrease levels of CXC chemokine ligand (CXCL) chemokines, including CXCL1, CXCL5 and CXCL8, in experimental prostate ...
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Application of [14C]-progesterone to the leaves of Nerium oleander L. (Apocynaceae) resulted in the formation of [14C]-digitoxigenin and [14C]-oleandrigenin glycosides; the labelled aglycones were obtained after hydrolysis from the cardenolide extract. Both radioactive cardenolide aglycones were further transformed by the leaves of Nerium oleander L. to the corresponding 3-O-β-glucosides digitoxigenin glucoside and oleandrigenin glucoside. It could be shown that both cardenolide glucosides are genuine constituents of the cardenolide fraction of Nerium oleander L. leaves. The structures of these newly identified compounds were verified by 1H-NMR and FAB+ mass spectroscopy and by enzymatic cleavage of the glycosidic bond with a β-glucosidase from Helix pomatia. ...
We showed before that in isolated cardiac myocytes, digitalis binding to NaK- ATPase α1 isoform initiates selective activation of the class 1A PI3K/Akt signaling pathways, causing myocyte hypertrophy akin to physiological growth. This suggests that putative endogenous digitalis-like compounds (EDLs) may have beneficial effects on cardiac function and growth, including the ability to antagonize pressure overload-induced hypertrophy. To test this hypothesis, it was necessary to use a transgenic mouse, because the natural rodent NaK-ATPase α1 (in contrast to that of man) is highly insensitive to digitalis, and not likely to respond to physiological levels of EDLs. Hence we generated a NaK-ATPase α1-sensitive mouse (α1 S/S) by amino acid substitutions, leaving the other Na,K-ATPase isoforms in their natural states. This transgenic mouse and the Wt control (α1R/R) were then subjected to transverse aortic constriction (TAC) or sham operation, and compared. There were no differences in body ...
A new cardenolide, 12 beta, 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12 beta-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12 beta-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16 alpha-hydroxyasclepin (10), 16 alpha-acetoxycalotropin (11), and 16 alpha-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC(50) value of 0.02 mu M against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC(50) values of 0.69 and 1.46 mu M, respectively. (C) 2009 Elsevier ...
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In this study, we have examined the antioxidant activity and total phenolic content of different extracts (including water, methanol, water : methanol and acetone) of Nerium oleander L. grown in the north of Iran by employing various in-vitro assay, i.e. DPPH free radical scavenging, reducing power and total antioxidant capacity through the Mo (VI) reduction. The extracts showed different levels of efficacy in each assay in a dose-dependent manner. Methanolic and aqueous methanolic extracts with the highest amount of total phenolic (by using the Folin-Ciocalteu phenol reagent method), were the most potent antioxidant in all of the assays that were used. According to the results of present study, Nerium oleander L. flowers were found to serve as a potential source of natural antioxidants.
Looking for online definition of cardenolide in the Medical Dictionary? cardenolide explanation free. What is cardenolide? Meaning of cardenolide medical term. What does cardenolide mean?
Although volume and vasoconstriction have been considered polar elements in a useful pathogenetic hypertension model, many observations suggest that vasoconstriction is involved in volume-dependent hypertension, reflecting the effect of a digitalis-like factor. To examine that possibility, we assessed the depressor responses to Digibind, an antibody Fab directed against digoxin, in a volume-dependent model--DOCA-salt-induced hypertension in rats. Digibind (10 mg/kg, intravenously) induced a gradual blood pressure fall over 2 h that was sustained for 4 h (P | .001). Blood pressure did not fall with Digibind when DOCA was administered without salt or a high-salt intake was provided without DOCA. The intracellular sodium content of the rat aorta, measured by atomic absorption spectroscopy after cold choline wash, was increased in the DOCA-high-salt rats (23.3 +/- 2.7 mEq/L) compared to control rats (12.1 +/- 0.8 mEq/L; P | .001). Aorta sodium content, in parallel with blood pressure, was not increased
Oleander, Nerium oleander,[1] is a poisonous shrub. It is commonly used in gardens because of its pink colored flowers.[2][3] Nerium oleander is native to northern Africa, the eastern Mediterranean basin and southeast Asia. Oleander prefers dry, warm climates and may naturalize in such areas.[4] Recently, scientific studies on cardenolide oleandrin show that it may be used to prevent mutagenesis.[5]. ...
Nerium oleander is an evergreen shrub reaching 6 to 12 feet in height and spread, occasionally 20 feet. Not cold hardy, so subject to freeze damage. The leaves
Flores em Israel - flores exóticas (Marthas backyard) - Digitalis purpurea,Foxglove, Purple Foxglove, Ladys Glove,אצבעונית ארגמנית
Nerium skin care is an age-defying skin care cream developed from Nerium oleander. Nerium skin care will help you Retain that youthful, healthy glow for life.
Journal of Chemistry is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles on all aspects of fundamental and applied chemistry.
Oleander is a tough plant that blooms even in drought and punishing heat but, unfortunately, the shrub is sometimes preyed upon by a few common oleander pests. Click here to learn what you can do about oleander plant pests.
Prolonged exposure to 17-beta-estradiol (E2) is important in causing breast cancer. The carcinogenic effects are imposed on the estrogen receptors on the surface of breast cells. Anti-estrogen treatments, such as by tamoxifen and by the aromatase inhibitors, are beneficial at first, but, resistance to them develops and the cancer grows. Aromatase enzyme promotes the conversion […]. View Post ...
Novotny, J; Mudgett, hunter M.; Haber, E; and Margolies, M N., "Primary structure of a mouse anti-digoxin hybridoma antibody. Abstr." (1981). Subject Strain Bibliography 1981. 1000 ...
Light micrograph of the central region of a foxglove (Digitalis purpurea) flower. At centre are the female reproductive parts of the plant (the carpal). The long style is topped by the stigma. Surrounding the carpal are the male stamens. Each stamen consists of a filament (stalk) and an anther (yellow) that contains pollen grains (white). The cream petal is in the background. - Stock Image C036/0907
Anatomy and Physiology: The Unity of Form and Function with OLC Bind-in Card Hardcover: 1216 pages Publisher: McGraw-Hill Science/Engineering/Math; 3 edition (December 31, 2002) Language: English ISBN: 0072429038 Author: Kenneth S. Saladin Format: PDF Size: 85M
Network Forgetting a new co-workers name is a common problem, but admitting it openly is a surprisingly welcomed solution, and it can open the door to positive rapport. Eric Cai writes more from his experience.. ...
Adelfa / Nerium oleander / SOUTH SEA ROSE - Philippine Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Stuart
A garden picture of Digitalis purpurea, Preferred common namecommon foxglove FamilyPlantaginaceae Digitalis can be biennials or usually short-lived perennials forming a rosette of simple leaves with bell-shaped flowers in slender, erect, usually one-sided racemes D. purpurea is a biennial or short-lived perennial, freely self-sowing, with a rosette of softly hairy, oval leaves and tall, one-sided spires of pendant, tubular, bright rosy-purple flowers 6cm long, spotted within, in summer Other common names bloody bells bloody finger cow flop dead mans bells dead mens bells dogs lugs dragons mouth fairy bells fairy fingers fairy gloves fairy thimbles fairys cap fairys petticoat fairys thimble finger flower flap dock folks gloves fox finger gloves of Mary ladys fingers ladys gloves ladys thimble lions mouth lusmore lustmore pop dock thimble finger thimble flower throat root witches bells witches fingers witches gloves witches thimbles
Digitalis purpurea is a biennial foxglove that produces only a basal rosette of light green, oblong leaves in the first year from seed. Flowers are borne in the second year in terminal, one-sided racemes atop leafy, 2-4 tall (infrequently to 5) spires arising from the centers of the basal rosettes. Pendulous, 2-3" long, tubular, funnel-shaped, dark rose-pink to purple (sometimes white) flowers with purple and white spots inside are closely grouped along each spike. Flowers are attractive to hummingbirds. Plant leaves are a source of the drug digitalis and are highly poisonous. A late spring bloomer that reaches its peak about the same time as roses begin to bloom. After flowering, plants can become somewhat scraggly by late summer, and, because they are biennials, consideration may be given to removing them from the garden as soon as they release their seed. Individual flowers resemble the snipped off fingers of a glove, hence the common name of foxglove ...
A new cardenolide tupichinolide (1) and a new steroidal saponin tupichinin A (2), together with seven known compounds, were isolated from the rhizomes of Tupistra chinensis. Their structures were established using spectroscopic analysis and chemical methods. Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. (C) 2012 Elsevier B.V. All rights reserved ...
Next to the main building a dwarf, pink-blossomed oleander is at its peak of flowering, as shown at http://www.backyardnature.net/n/11/110918om.jpg.. Most oleanders, which are NERIUM OLEANDER, are taller, up to 20 feet (6m), less bushy, and often have leaves with a grayer bloom. But theres a whole world of different kinds of oleanders, because of their prettiness, drought tolerance and ability to thrive in poor soil and fairly polluted air. Oleanders are among the worlds most planted woody species, at least in warmer areas. Over 400 cultivars have been named, some with flower colors not generally seen in Nature. You might enjoy browsing a page featuring many oleander cultivars -- ones with evocative names like Marrakesh, Mary Constance, Mrs. Kelso, Sister Agnes and Pleasants Postoffice Pink -- at http://www.oleander.org/varieties.html.. If you have a highly modified oleander cultivar, how do you know you have a real oleander? For one thing, an oleanders flower clusters, or ...
Preeclampsia (PE) complicates from 5 to 10% of pregnancies and it is a number one cause of maternal and fetal morbidity and mortality worldwide. Nevertheless, a specific and highly effective therapy of this disorder does not exist. As illustrated by therapeutic efficacy of anti-digoxin antibody (DIGIBIND) in preeclampsia, endogenous digitalis-like sodium pump ligands play an important role in the pathogenesis of this syndrome. Previously, we demonstrated that levels of endogenous bufadienolide Na/KATPase inhibitors are elevated in patients with PE, and that antibody to marinobufagenin lower blood pressure in rats with pregnancy-induced hypertension and ex vivo reverse inhibition of the Na/K-ATPase from erythrocytes from patients with PE. Most recently, we developed three anti-MBG monoclonal antibodies which in lower blood pressure in several rat experimental models.. We are proposing a pilot proof-of concept study aimed to demonstrate that MBG is target for DIGIBIND in preeclampsia. If ...
Mesotelioma de pulmão - DR H. Ziya Ozel - Nerium oleander Nerium oleander Usou ANVIRZEL extrato da planta CASE REPORT Diagnosis: Mesothelioma - HD A 53-year-old woman presented in September 1991 to Adiyaman
Journal of Parasitology Research is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of basic and applied parasitology. Articles covering host-parasite relationships and parasitic diseases will be considered, as well as studies on disease vectors. Articles highlighting social and economic issues around the impact of parasites are also encouraged. As an international, Open Access publication, Journal of Parasitology Research aims to foster learning and collaboration between countries and communities.
Until recently, Phoenix Biotech was the only active manufacturer of the patented oleander medication Anvirzel, which has passed FDA phase I toxicity trials and has been used successfully outside the United States for many years, including the Salud Integral Clinic in Honduras, which Phoenix Biotech owns. Within the past month or so, Phoenix has spun off the Anvirzel portion of its operations, including the Honduras facility, and is now concentrating all of its efforts in oleander medicine on a new pill form and proprietary extraction method that uses liquid carbon dioxide and micro-fine particles of oleander and which is reported to result in a greater concentration of the cardiac glycosides and no loss of all the supporting compounds ...
From the parotid secretion of the South African toad, Bufo regularis, the following principles have been isolated and studied pharmacologically:. A. Cholesterol.. B. Regularo-bufagin, C23H34O5, which has a digitalis-like action. The minimal emetic dose in pigeons is 0.3 mgm., that in cats 0.09 mgm., and the average fatal dose in cats is 0.15 mgm. per kilogram.. C. Regularo-bufotoxin, C37H60O10N4, which also has a digitalis-like action. The minimal emetic dose in pigeons is 0.35 mgm., that in cats 0.275 mgm., and the average fatal dose in 10 cats is 0.48 mgm. per kilogram. Both regularo-bufagin and -bufotoxin have a pressor action, and stimulate isolated smooth muscle organs. The cardiac action of regularo-bufotoxin seems to be relatively more persistent than that of regularo-bufagin.. D. Regularo-bufotenine, which is an indole derivative, in the form of a flavianate. It stimulates both the isolated rabbits intestines and guinea pigs uteri, and raises the arterial blood pressure, its activity ...
Nephritis after scarlatina. Cystitis. Inflammation of neck of bladder ; after passing a few drops the desire to urinate is increased and the patient walks about in great distress, associated with tenesmus of rectum ; these symptoms have indicated the use of the drug for the relief of acute inflammation in chronic enlargement of the prostate. In inflammation of the kidneys of the chronic form it is sometimes of temporary value when there is threatened failure of the heart, or very scanty or suppressed urine, with œdema of the lungs, etc ...
While the monarchs might be fun to spot in your garden, make sure to keep pets and children from trying to sample the insects. As larvae, the monarchs eat a strict diet of only milkweed, which helps them develop cardenolides - a poison that works like digitalis - as adults. How much the larvae ate is directly proportionate to how poisonous the adult becomes ...
Brown thrashers, grackles, robins, cardinals, sparrows, scrub jays and pinyon jays are known to feed on monarchs. Some of these birds avoid the body parts with higher concentrations of cardenolides by eating only the abdomens or by eating this kind of food in moderation. When monarchs arrive in their wintering grounds in Mexico they are plump with stored fats that will keep them through the winter. A whole new set of predators is eagerly awaiting them. Mice feast mostly on dead and dying butterflies that have fallen to the ground. Several species of birds, especially black-backed orioles and black-headed grosbeaks take a heavy toll on the millions of wintering butterflies. A few months after their arrival in Mexico, the monarchs may have lost a fair amount of toxins, making them more appetizing. It is estimated that between 7 and 40% of them fall victims to predation in their roosting grounds ...
The duality of death and beauty extends to the seed cases. Flourished with golden plumes and parachuting seeds, the oleander is a dreamy design. I still remember how a friend remarked that they made her "want to fly." And indeed, that is what they do, with a passing breeze. And yes, these beauties are also poisonous, stopping the heart - literally and figuratively, if you will.. Romantics aside, the oleander is an interesting specimen of form and function, particularly in the seed pod. Lets start at the beginning: pollination. Its numerous flowers offer neither nectar nor easy access to pollen, so while few blossoms will yield fruit, each pod can hold hundreds of seeds. This strategy allows the flower to allocate lots of resources to each pod and its concentrated stuffing of downy seeds. The high thread count is unwoven when the pod bursts open and the tufted clouds disperse. And while the oleander does grow quite well in dry conditions, its native habitats are along stream banks in the ...
In this study, an efficient protocol for the regeneration of encapsulated explants of oleander (Nerium oleander L.) has been developed. Shoot tips and 1st nodal segments below the shoot tip, from in vitro-derived oleander microshoots, were encapsulated in 2.5% sodium alginate prepared in liquid MS sucrose-free nutrient medium and hardened in 50 mM of calcium chloride producing solid beads, uniform ...
Following in vitro safety testing and IUCAC approval, we applied increasing concentrations of topical NSPI drops (0.002% to 0.7%) in two canines with normal intraocular pressures. Drops were applied routinely in both animals. We collected ophthalmic data including: rebound tonometry (ICARER), indirect ophthalmoscopic video fundus examination, and slit lamp and external inspection for surface and intraocular toxicity. We monitored for systemic toxicity with urine analysis and venous blood sampling for hematology, serum chemistries and liver function tests.. ...
Phoenix Biotechnology is developing therapeutics derived from herbal extracts of Nerium oleander for viral infections, including HIV infections and
Although the name foxglove (Digitalis spp.) refers to a group of short-lived perennial and biennial plants, it is most often used to refer to the most common of those plants, Digitalis purpurea. The ...
This plant grows upto 3 feet tall producing purple, white or pink, sometimes dotted inside the central stalk. Its Latin name is Digitalis purpurea. If we eat any part of the plants in wild, we would likely get heart problems, after a spell of nausea, vomiting, cramps, diarrhoea and pain in the mouth. If we a doctor, he might administer charcoal to absorb the toxin or pump your stomach, and might also administer drugs to bring your heart rate back to normal. Other names for this plant include fairy bells, rabbit flower, throatwort and witches thimbles ...
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Question: My oleanders are losing lots of lower leaves, which turn yellow and fill with black spots. Is this normal?Answer: Its that time of the year when many plants change out the foliage. The
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An angiotensin I-like immunoreactive substance (AI) was evidenced by a radioimmunoassay technique in the rat brain. The concentration of AI was significantly greater in the pineal tissue as compared to the hypothalamic or cerebral cortex tissue (p less than 0.001); its concentration was also higher in the pineal of the homozygous rats with hereditary diabetes insipidus (Brattleboro strain) as compared to the same tissue of the normal rats (p less than 0.001). The possible role of a pineal angiotensin system in the hydrosaline regulation is discussed ...
Oleander (Nerium oleander) is an ornamental indoor shrub found in Canadian homes and offices. This plant is quite toxic if the leaves or stems are ingested. Humans have died after eating meat that was skewered with oleander stems. Ingesting a single leaf may be toxic to a person. The dry leaves remain toxic. Cattle, horses, and sheep have been poisoned experimentally (Wilson 1909, Kingsbury 1964). Livestock are not likely to have access to oleander in Canada. Children and family pets should be prevented from ingesting green or dry leaves, chewing stems, or sucking the nectar from flowers.. ...
Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (NAE-8®) Kathleen F Benson,1 Robert A Newman,2,3 Gitte S Jensen1 1NIS Labs, Klamath Falls, Oregon, USA; 2University of Texas MD Anderson Cancer Center, Houston, TX, USA; 3Nerium Biotechnology, Inc, San Antonio, TX, USA Objective: The goal for this study was to evaluate the effects of an Aloe vera-based Nerium oleander extract (NAE-8®), compared to an extract of A. vera gel alone (ALOE), and to an aqueous extract of N. oleander (AQ-NOE) in bioassays pertaining to dermatologic potential with respect to antioxidant protection, anti-inflammatory effects, and cytokine profiles in vitro. Methods: Cellular antioxidant protection was evaluated in three separate bioassays: The cellular antioxidant protection of erythrocytes (CAP-e) assay, protection of cellular viability and prevention of apoptosis, and protection of intracellular reduced glutathione levels, where the last
We reconstructed the macroevolution of two adaptations to host plant toxins, cardenolide resistance and sequestration. We found that both traits are probably basal features of the Lygaeinae. Our findings demonstrate that the coevolutionary response of herbivores to plant toxins and their use as an acquired defence involves a combination of traits not just a single adaptation. As several insect species with cardenolide-resistant Na+/K+-ATPase were also shown to sequester the toxins, the two traits might often be linked and are probably co-adaptive (e.g. Chrysochus auratus: Chrysomelidae; Poekilocerus bufonius: Pyrgomorphidae; Danaus plexippus: Nymphalidae; [41-45]). However, the leaf beetle Labidomera clivicollis which feeds on Asclepias species without sequestering cardenolides but still has a Na+/K+-ATPase bearing resistance conferring substitutions [7] and cardenolide-sequestering arctiid moths (e.g. Empyreuma pugione) with sensitive Na+/K+-ATPases [34] indicate that both traits are not ...
Ouabain, that has been isolated from bovine adrenals and hypothalamus, is a new cardiotonic steroid hormone, which is either synthesized in the adrenals or stored there after it has absorbed from the diet. Little is known ,i,in vivo,/i, which events may lead to the release of ouabain into blood. Moreover, a binding protein for cardiotonic steroids exists in blood, which binds cardiac glycosides with high affinity. It may affect the action of endogenous ouabain on heart and circulation, but the physiological function of this protein is unclear. To realize, which physiological stimuli ,i,in vivo,/i, may affect blood concentrations of endogenous ouabain and which function the cardiotonic binding protein may have in modulating ouabain effects, the effect of physical exercise on endogenous ouabain was studied and the tissue distribution of its binding protein was investigated. We found that endogenous ouabain changes rapidly in blood upon physical exercise and behaves like expected for a hormone of ...
Introduction. Poisoning of livestock by cardiac glycoside-containing plants has the greatest economic impact of all plant-associated poisonings in the Republic of South Africa. Collectively, they are held responsible for 33% of all mortalities from plant poisonings of cattle and 10% of those in small stock (Kellerman, Naudé & Fourie 1996).. Chemically, two major groups of cardiac glycosides, namely the cardenolides and bufadienolides, are recognised (Steyn & Van Heerden 1998). Poisoning of livestock by bufadienolide-containing plants, which surpasses cardenolide-induced poisonings in importance, may either be acute or chronic. Tulp poisoning (induced by various Moraea species) and slangkop poisoning (caused by various Drimia species) induce only acute intoxication, as these species contain non-cumulative bufadienolides (Kellerman et al. 2005). On the other hand, members of three genera of the Crassulaceae (Cotyledon, Tylecodon and Kalanchoe), generally referred to as plakkies, may cause either ...
Indicated in affections of the heart, with weak, irregular contractions, causing a fluttering sensation. Sense of faintness and fear of death from dread that the heart?s action will suddenly cease. Of great value in organic heart disease, with scantiness of urine and dropsical effusion. Also in hepatic disease with jaundice, ascites, nephritis with cardiac symptoms, percarditis with effusion; pneumonia, especially of the aged, with weakness of the heart?s action. Less often in urethritis, specific and non-specific, and in prostatitis ...
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Rare spontaneous variants of the anti-digoxin antibody-producing hybridoma 40-150 (Ko = 5.4 x 10(9) M-1) were selected for altered antigen binding by two-color fluorescence-activated cell sorting. The parent antibody binds digoxin 890-fold greater than digitoxin. The variant 40-150 A2.4 has reduced affinity for digoxin (Ko = 9.2 x 10(6) M-1) and binds digoxin 33-fold greater than digitoxin. A second-order variant, derived from 40-150 A2.4 (designated 40-150 A2.4 P.10), demonstrated partial regain of digoxin binding (Ko = 4.4 x 10(8) M-1). The altered binding of the variant 40-150 A2.4 was accounted for by a point mutation resulting in substitution of arginine for serine at position 94 in the heavy chain variable region. Antibody 40-150 A2.4 P.10 also contains this arginine but owes its enhanced antigen binding to deletion of two amino acids from the heavy chain amino terminus. This unusual sequence alteration in an immunoglobulin framework region confers increased affinity for antigen.
1. The presence of immunoreactive substance P (I-SP) in the vagus nerve of 5 species was demonstrated by radioimmunoassay. Different amounts of SP per unit weight were found: Guinea pig > cat >...
The treatment of cardiac failure is complicated by the difficulty in determining the optimal therapeutic response and undesirable side-effects. The side-effects of cardiac glycosides can be...
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The Mirror Effect involves a certain progression of steps: (1) the viewer consumes a consistent diet of images of celebrities behaving in attention-getting, narcissistic ways, images that make the behavior appear both entertaining and attractive. (2) The viewer develops a preoccupation with these images, to the point the behavior begins to seem normal, even desirable. (3) Consciously or unconsciously, the viewer begins to adopt the behavior, with detrimental or even dangerous consequences. Though its not a necessary step, the cycle is completed if (4) the viewer then takes advantage of open-access media to indulge his own narcissistic urges, reflecting the behavior back to the public at large." ~The Mirror Effect, page 136-137 ...
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Interviews Have you ever wondered why you never got a callback for that interview? Or perhaps, youre wondering how you can make sure that you do get called in the future. Either way, wouldnt it be nice to know how to increase your chances of getting an interview? I sat down with a Human Resources professional to find out how he evaluates resumes and select who to interview. ...
Few cases of IIH managed with digoxin have been reported, to our knowledge. Digoxin acts on the ouabain-sensitive Na+/K+ ATPase receptors in the choroid plexus, thereby decreasing CSF production. Neblett et al12 discussed 3 cases in which the use of digoxin correlated with decreasing CSF production by up to 78%. They concluded that digoxin may be beneficial to conditions of increased CSF pressure. Schott and Holt,13 however, used digoxin in a patient with IIH without success. This instance may illustrate that there is more than 1 mechanism for the increased intracranial pressure and perhaps the mechanism in our patient is different from the mechanism in the patient noted by Schott and Holt.13 Borsody et al14 noted that levels of brain ouabain-like compounds, which inhibit the Na+/K+ ATPase receptors, were lower in patients with unsuccessfully managed IIH. Digoxin is similar to ouabain-like compounds, which could explain our patients improvement. ...
Looking for online definition of cardiac glycosides in the Medical Dictionary? cardiac glycosides explanation free. What is cardiac glycosides? Meaning of cardiac glycosides medical term. What does cardiac glycosides mean?
nanogram/ml. However, serum digoxin concentration should be interpreted in the clinical context. Toxicity may occur with lower digoxin serum concentrations. In deciding whether a patients symptoms are due to digoxin, the clinical state together with the serum potassium level and thyroid function are important factors (see Section 4.9). Determination of the serum digoxin concentration may be very helpful in making a decision to treat with further digoxin, but other glycosides and endogenous digoxin-like substances, including metabolites of digoxin, can interfere with the assays that are available and one should always be wary of values which do not seem commensurate with the clinical state of the patient. Observations while temporary withholding digoxin might be more appropriate. Sinoatrial disorder Cardiac amyloidosis Myocarditis Beri-beri heart disease Constrictive pericarditis Exercise tolerance Withdrawal Electrocardiograhy Hypokalaemia Hypokalaemia Hypoxia, hypomagnesaemia and ...
References:. Agrawal, A.A. 2005. Natural selection on common milkweed (Asclepias syriaca) by a community of specialized insect herbivores. Evolutionary Ecology Research, 7: 651 667.. Agrawal, A.A. & P.A. Van Zandt. 2003. Ecological play in the coevolutionary theater: Genetic and environmental determinants of attack by a specialist weevil on milkweed. Journal of Ecology 91: 1049-1059.. Arnett, R.H., Jr., M.C. Thomas, P. E. Skelley & J.H. Frank. (editors). 2002. American Beetles, Volume II: Polyphaga: Scarabaeoidea through Curculionoidea. CRC Press. 861 pp.. Fordyce, J.A. & S.B. Malcolm. 2000. Specialist weevil, Rhyssomatus lineaticollis, does not spatially avoid cardenolide defenses of common milkweed by ovipositing into pith tissue. Journal of Chemical Ecology, 26: 2857 2874.. Nishio, S., M.S. Blum, S. Takahashi. 1983. Intraplant distribution of cardenolides in Asclepias humistrata (Asclepiadaceae), with additional notes on their fates in Tetraopes melanurus (Coleoptera: Cerambycidae) and ...
De Roode and Hunter discovered in 2010 that female monarch butterflies infected with the parasite Ophryocystis elektroscirrha prefer to lay their eggs on species of milkweed that will make their caterpillars less sick. Monarchs appear to have evolved the ability to medicate their offspring by choosing milkweed plants with high levels of cardenolides, a class of toxins that appear to kill the parasites ...
Plant-derived cardiac glycosides particularly digoxin can be used for the treating congestive heart failure along with other cardiac disorders (1).05) Figure 1: Cardiac glycoside items of detoxified TSM...
Unfortunately, compounds like oleandrin can also be insidiously toxic, with high doses capable of decreasing cardiac function and reducing the availability of oxygen to the tissues of the body. Without treatment, this can most certainly be fatal. Multiple cases of deaths due to ingestion (accidental or otherwise) ingestion of oleander and preparations of its leaves. In 2000, two toddlers, aged two and three years old, died as a result of ingesting the leaves. This case is in itself unusual, as the leaves are reported to have an incredibly bitter taste, with Dr. Clarke, a medical toxicologist and director of the California Poison Control Centre, commenting that "There is not a single other case in the American literature that I know of of people eating oleander leaves and dying ...
Ubiquitously expressed sodium pumps are best known for maintaining the ionic gradients and resting membrane potential required for generating action potentials. However, activity- and state-dependent changes in pump activity can also influence neuronal firing and regulate rhythmic network output. Here we demonstrate that changes in sodium pump activity regulate locomotor networks in the spinal cord of neonatal mice. The sodium pump inhibitor, ouabain, increased the frequency and decreased the amplitude of drug-induced locomotor bursting, effects that were dependent on the presence of the neuromodulator dopamine. Conversely, activating the pump with the sodium ionophore monensin decreased burst frequency. When more "natural" locomotor output was evoked using dorsal-root stimulation, ouabain increased burst frequency and extended locomotor episode duration, whereas monensin slowed and shortened episodes. Decreasing the time between dorsal-root stimulation, and therefore interepisode interval, also ...
This is the more popular of only 2 species of evergreen shrubs or trees in the Nerium genus which is part of the larger Dogbane family. It is native from southwest Asia into China but is very commonly grown in the region around the Mediterranean Sea. Variable in habit, the fast growing Oleander typically is multi-stemmed, bushy and erect in habit, reaching around 15 feet if left unpruned. Some records include: largest on record - 35 x 36 feet with a trunk diameter of 1.7 feet; 1st year - 5 feet; 7 years - 15 feet ( avg ); fastest recorded growth rate - 5 feet ...
One of the finest of all Hawkmoths. The larvae are very fast growing indeed and they consume a lot of food. Apart from Oleander Nerium, the larvae thrive on Periwinkle Vinca, and these are being reared on Privet Ligustrum.. Larvae cannot be posted outside GB. See XXP for courier delivery to Europe, which does not guarantee safe delivery but is very fast (1-2 days), and minimises risk.. ...
Digitalis-like steroids and related agents have been a mainstay in the treatment of congestive heart failure ever since the publication, in 1785, of Witherings seminal monograph on foxglove. Heart failure refers to the clinical syndrome that results when the heart is unable to pump sufficient blood to keep up with the metabolic demands of the body. Congestive heart failure is characterized by excessive neuronal and hormonal-mediated fluid retention, expanded intravascular volume, high pulmonary and systemic venous pressures with consequent dyspnea (shortness of breath) on exertion, reduced exercise tolerance, and fatigue. Most heart failure patients also have impaired ventricular systolic function and depressed cardiac output; these are the patients most often treated with digitalis glycosides. These drugs are positive inotropic agents and enhance cardiac contraction. The "cardiotonic steroids" cause cardiac muscle to lose K+ and gain Na+ because they inhibit the Na+ pump (Na+,K+-ATPase), a ...
The management of patients with suspected or known cardiac glycoside poisoning is complicated by the variable time course in toxicity and unpredictable dose-response relationship. Management is also complicated by the fact that there is variability in the onset of toxicity as discussed above. For example, death has occurred after ingestion of one or two yellow oleander seeds, while other patients have survived after consuming 10 or more seeds without requiring pacing or anti‐digoxin antitoxin.. Given the structural similarity of the cardiac glycosides, treatments are frequently extrapolated from digitalis poisoning. However, in recent years, there have been an increasing number of clinical trials assessing yellow oleander poisoning. Currently, randomized controlled trials are only available for yellow oleander poisoning, so data supporting recommendations for poisoning with other cardiac glycosides including digoxin is of low quality.. In general, patients with acute poisoning should be ...
Certain steroids obtained from plants are potent inhibitors of the Sodium-Potassium pump. Digitoxigenin and ouabain are members of this class of inhibitors, which are known as cardiotonic steroids because of their effects on the heart. These compounds inhibit the dephosphorylation of the E2-P form of the ATPase when applied on the extracellular face of the membrane. Digitalis is a mixture of cardiotonic steroids derived from the dried leaf of the foxglove plant (Digitalis purpurea). The compound increases the force of contraction produced by the heart, and is the drug of choice in heart failure. The inhibition of the sodium potassium pump by Digitalis leads to a higher level of Na+ inside the cell. The diminished Na+ gradient results in a slower intrusion of Ca2+ by the sodium-calcium exchanger. The increase of Ca2+ enhances the ability of the cardiac muscle to contract. Digitalis was being used long before its discovery through foxglove extract. People were using it to cure people with ...
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Our retrospective analysis of patients from the DIG trial demonstrates that the clinical effects of digoxin in women, as in men, are significantly influenced by serum concentration, with divergent outcomes relative to placebo at low versus high concentrations. Specifically, there was no evidence that digoxin increased mortality in women at low serum concentrations by any of our analytical approaches. The point estimate for the relative risk of death on digoxin versus placebo was below unity for women at detectable serum concentrations ,1 ng/ml. In addition, digoxin substantially reduced the risk of hospital stay for worsening HF and the risk of the combined end point of mortality and HF hospital stay in women at low SDCs (0.5 to 0.9 ng/ml). In contrast, the risk for mortality was greater than placebo when serum concentrations were ≥1.2 ng/ml, and there was no reduction in the risk of the combined end point at higher serum concentrations. Our study cannot define the mechanisms responsible for ...

Glycosylation of Cardenolide Aglycones in the Leaves of Nerium oleander L.  - Publikationsserver der Universität RegensburgGlycosylation of Cardenolide Aglycones in the Leaves of Nerium oleander L. - Publikationsserver der Universität Regensburg

It could be shown that both cardenolide glucosides are genuine constituents of the cardenolide fraction of Nerium oleander L. ... the labelled aglycones were obtained after hydrolysis from the cardenolide extract. Both radioactive cardenolide aglycones were ... the labelled aglycones were obtained after hydrolysis from the cardenolide extract. Both radioactive cardenolide aglycones were ... Paper, D. und Franz, Gerhard (1989) Glycosylation of Cardenolide Aglycones in the Leaves of Nerium oleander L. Planta Medica 55 ...
more infohttps://epub.uni-regensburg.de/22527/

中国科学院昆明植物研究所机构知识库(KIB OpenIR): Cytotoxicity of cardenolides and cardenolide glycosides from中国科学院昆明植物研究所机构知识库(KIB OpenIR): Cytotoxicity of cardenolides and cardenolide glycosides from

Asclepias curassavica ; Asclepiadaceae ; Cardenolide ; Cardenolide glycoside ; Cytotoxicity 英文摘要: A new cardenolide, 12 beta, ... Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica. 作者: Li, Jun-Zhu1; Qing, Chen2; Chen, Chang- ... Li, JZ; Qing, C; Chen, CX; Hao, XJ; Liu, HY.Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica, ... 14 beta-dihydroxy-3 beta, 19-epoxy-3 alpha-methoxy-5 alpha-card-20(22)-enolide (6), and a new doubly linked cardenolide ...
more infohttp://ir.kib.ac.cn/handle/151853/2901

Supplemental data to The genome and transcriptome of common milkweed (Asclepias syriaca): resources for evolutionary,...Supplemental data to 'The genome and transcriptome of common milkweed (Asclepias syriaca): resources for evolutionary,...

This dataset contains a draft assembly of the common milkweed (Asclepias syriaca) nuclear genome, linkage group information, and gene family counts for Asclepias and related species. The genome assembly is accompanied by annotation of gene models, repeat models, transfer RNAs, and open reading frames, and mapping information of Asclepias transcripts, Calotropis transcripts, and Coffea proteins onto the assembled scaffolds. The linkage group information includes data input into the linkage group analysis, R scripts for processing, and a final list of scaffolds assigned to linkage groups. Additional data includes the coding sequence alignment of P5βR paralogs described in the article and a table of gene family counts in Asclepias, other Apocynaceae, coffee (Coffea), and grape (Vitis ...
more infohttps://ir.library.oregonstate.edu/concern/datasets/vd66w525h

Cardenolide - WikipediaCardenolide - Wikipedia

Cardenolide is a type of steroid. Many plants contain derivatives, collectively known as cardenolides, including many in the ... The cardenolide content in butterflies deters most vertebrate predators, except a few which have evolved to become cardenolide- ... form of cardenolide glycosides (cardenolides that contain structural groups derived from sugars). Cardenolide glycosides are ... Species such as the monarch, queen, and plain tiger ingest the cardenolides contained in the milkweeds (Asclepias) that they ...
more infohttps://en.wikipedia.org/wiki/Cardenolide

Cardenolide dictionary definition | cardenolide definedCardenolide dictionary definition | cardenolide defined

... plural cardenolides) 1. (organic chemistry) Any of many steroid lactones present in plants as glycosides; they are all toxic, ... cardenolide. Noun (plural cardenolides). *(organic chemistry) Any of many steroid lactones present in plants as glycosides; ... "cardenolide." YourDictionary, n.d. Web. 05 December 2018. ,https://www.yourdictionary.com/cardenolide,. ... cardenolide. (n.d.). Retrieved December 05th, 2018, from https://www.yourdictionary.com/cardenolide ...
more infohttp://www.yourdictionary.com/cardenolide

Cardenolides of Adonis amurensis | Springer for Research & DevelopmentCardenolides of Adonis amurensis | Springer for Research & Development

Kharkov Chemical and Pharmaceutical Scientific-Research Institute. Leningrad Chemical and Pharmaceutical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 848-849, November-December, 1971. ...
more infohttps://rd.springer.com/article/10.1007/BF00567970

Milkweed Cardenolides and Their Comparative Processing by Monarch Butterflies ( Danaus plexippus L.) | SpringerLinkMilkweed Cardenolides and Their Comparative Processing by Monarch Butterflies ( Danaus plexippus L.) | SpringerLink

Cardenolide storage in Danaus chrysippus (L.) with additional notes on D. plexippus. Proc. R. Soc. Lond. B., 190:1.Google ... Cardenolides of some species of the genus Asclepias. Farm. Glas., 23:3. [Chem. Abstr., 67:8686g]Google Scholar ... Cardenolides in the milkweed plant and feeding by the milkweed bug. Ann. Entomol. Soc. Am., 64:1173.Google Scholar ... Cardenolides in leaves of Asclepias glaucophylla. Rev. Port. Quim., 6: 97. [Chem. Abstr., 64:5549f]Google Scholar ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-2646-5_3

Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha | WaterstonesSpectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides by Viqar Uddin Ahmad, Anwer Basha | Waterstones

Cardenolides by Viqar Uddin Ahmad, Anwer Basha from Waterstones today! Click and Collect from your local Waterstones or get ... Spectroscopic Data of Steroid Glycosides: Spirostanes, Bufanolides, Cardenolides: Volume 3 (Paperback). Viqar Uddin Ahmad ( ...
more infohttps://www.waterstones.com/book/spectroscopic-data-of-steroid-glycosides-spirostanes-bufanolides-cardenolides/viqar-uddin-ahmad/anwer-basha/9781489997135

Cardenolide | definition of cardenolide by Medical dictionaryCardenolide | definition of cardenolide by Medical dictionary

... cardenolide explanation free. What is cardenolide? Meaning of cardenolide medical term. What does cardenolide mean? ... Looking for online definition of cardenolide in the Medical Dictionary? ... Cardenolides are a secondary chemical that milkweeds use as a defense compound; many plant and animal species use cardenolides ... Cardenolide , definition of cardenolide by Medical dictionary https://medical-dictionary.thefreedictionary.com/cardenolide ...
more infohttp://medical-dictionary.thefreedictionary.com/Cardenolide

Cardenolides from Gomphocarpus sinaicus and Pergularia tomentosa (Apocynaceae: Asclepiadoideae) deter the feeding of Spodoptera...Cardenolides from Gomphocarpus sinaicus and Pergularia tomentosa (Apocynaceae: Asclepiadoideae) deter the feeding of Spodoptera...

Each of the 6 cardenolides deterred feeding by S. littoralis, while two cardenolide standards, digoxin and digitoxin, did not ... Differences among cardenolides in their effect on feeding were associated with specific structural features. C. acutum is the ... Abdel-Azim NS (1998) A cardenolide glycoside from Gomphocarpus sinaicus. Phytochemistry 49:273-275CrossRefGoogle Scholar ... El-Askary H, Hölzl J, Hilal S, El-Kashoury E-S (1995a) A comparative study of the cardenolide content of different organs of ...
more infohttps://link.springer.com/article/10.1007%2Fs11829-011-9131-x

Cardenolides : Insights from chemical structure and pharmacological utilityCardenolides : Insights from chemical structure and pharmacological utility

Cardenolides: Insights from chemical structure and pharmacological utility. El-Seedi, Hesham R. ...
more infohttp://su.diva-portal.org/smash/record.jsf?pid=diva2:1304526

The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K PDK1 axis signaling.The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K PDK1 axis signaling.

Cardenolides are plant-derived toxic substances. Their cytotoxicity and the underlying mechanistic signaling axes have been ... The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K_PDK1 axis signaling.. 08 ... Ouabain, a representative cardenolide, was found to potently diminish TGEV titers and inhibit the TGEV-induced production of IL ... Summary of "The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K_PDK1 axis ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2108829/The-cardenolide-ouabain-suppresses-coronaviral-replication-via-augmenting-a-Na-K-ATPase.html

Revisiting Old Drugs as Novel Agents for Retinoblastoma: In Vitro and In Vivo Antitumor Activity of Cardenolides | IOVS | ARVO...Revisiting Old Drugs as Novel Agents for Retinoblastoma: In Vitro and In Vivo Antitumor Activity of Cardenolides | IOVS | ARVO...

Cardenolide. Ion pump effector. Cardiotonic. 0.44. 0.47. 2.1. 0.23. 0.04. Digoxin. Cardenolide. Ion pump effector. Prevention ... Cardenolide. Ion pump effector. Cardiotonic. 0.44. 0.47. 2.1. 0.23. 0.04. Digoxin. Cardenolide. Ion pump effector. Prevention ... Cardenolide. Ion pump effector. -. 2.6. 7. 4.6. 1.9. 3.8. Propachlor. Chlorophenylacetamide. Herbicide. -. 2.1. 2.1. 7.1. 6.2. ... Cardenolide. Ion pump effector. -. 2.6. 7. 4.6. 1.9. 3.8. Propachlor. Chlorophenylacetamide. Herbicide. -. 2.1. 2.1. 7.1. 6.2. ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2165263&resultClick=1

Plus itPlus it

The binding of cardenolides to the sodium pump causes rapid modifications in the levels of Src family kinase activity and ... The data from the present study thus show that the use of a cardenolide (UNBS1450) that binds to the sodium pump and therefore ... The binding of the UNBS1450 cardenolide to the sodium pump in human glioblastoma (GBM) cells dramatically impairs both their ... The binding of the UNBS1450 cardenolide to the sodium pump in human glioblastoma (GBM) cells dramatically impairs both their ...
more infohttp://cancerres.aacrjournals.org/content/66/8_Supplement/1053.5

On the structure of erycanoside, a cardenolide glycoside from Erysimum cancescens Roth]. - Semantic ScholarOn the structure of erycanoside, a cardenolide glycoside from Erysimum cancescens Roth]. - Semantic Scholar

... a cardenolide glycoside from Erysimum cancescens Roth]. by Luca Nover ... On the structure of erycanoside, a cardenolide glycoside from Erysimum cancescens Roth].. *. Luca Nover ...
more infohttps://www.semanticscholar.org/paper/%5BOn-the-structure-of-erycanoside%2C-a-cardenolide-Nover/335d7db9b9f3820a4d9cff1b48bd5f389c749d81

Oncotarget | A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2...Oncotarget | A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2...

A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle ... A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle ... A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle ... The new semisynthetic cardenolide analog AMANTADIG ((3β-[2-(1-amantadine)-1-on-ethylamine]-digitoxigenin) was previously ...
more infohttp://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=14644&path%5B%5D=46711

Cryptosin, a cardenolide from the leaves of Cryptolepis buchanani  - ePrints@IIScCryptosin, a cardenolide from the leaves of Cryptolepis buchanani - [email protected]

Cryptolepis buchanani;Asclepiadaceae;cardenolide; 3β-(d-deoxy glucose-oxy)-14β,11β-di- hydroxy-7α,8α-epoxy-12-oxo-5β-card-20 ( ... A new cardenolide named cryptosin was isolated from the leaves of Cryptolepis buchanani. By spectral studies and single crystal ... Venkateswara, R and Narendra, N and Viswamitra, MA and Vaidyanathan, CS (1989) Cryptosin, a cardenolide from the leaves of ...
more infohttp://eprints.iisc.ernet.in/31511/

Cytotoxic cardenolides from cheiranthus cheiri L.flowersCytotoxic cardenolides from cheiranthus cheiri L.flowers

Subjects: Cardenolides , Toxicity *Abstract English. The ethanolic extract of the flowers of the Egyptian species of ... Cytotoxic cardenolides from cheiranthus cheiri L.flowers Bull. Fac. Pharm. -Cairo Univ. 1998; 36 (3): 147-9 El Tanbouly N. D. ... Citation: N. D. El Tanbouly , Cytotoxic cardenolides from cheiranthus cheiri L.flowers, Bull. Fac. Pharm. -Cairo Univ. 1998; 36 ... Keywords: Cardenolides ,isolation & purification ,Cytotoxicity Immunologic ,Cytotoxicity Tests, Immunologic ,Plants ...
more infohttps://vlibrary.emro.who.int/imemr/cytotoxic-cardenolides-from-cheiranthus-cheiri-l-flowers/?skeyword=

Digoxin - the cardenolide that may give you van Goghs yellow vision - University of CopenhagenDigoxin - the cardenolide that may give you van Gogh's "yellow vision" - University of Copenhagen

Digoxin - the cardenolide that may give you van Goghs "yellow vision". NATURAL TOXIN. In the final years of Vincent van Goghs ... Digoxin - the cardenolide that may give you van Goghs "yellow vision" - University of Copenhagen. ...
more infohttps://natoxaq.ku.dk/toxin-of-the-week/digoxin/

中国科学院昆明植物研究所机构知识库(KIB OpenIR): A cytotoxic cardenolide and a saponin from the rhizomes of中国科学院昆明植物研究所机构知识库(KIB OpenIR): A cytotoxic cardenolide and a saponin from the rhizomes of

Tupistra chinensis ; Cardenolide ; Steroidal saponin ; Tupichinolide ; Tupichinin A ; Cytotoxicity 英文摘要: A new cardenolide ... A cytotoxic cardenolide and a saponin from the rhizomes of Tupistra chinensis. ... Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human ...
more infohttp://ir.kib.ac.cn/handle/151853/20395

Frontiers | Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death | PharmacologyFrontiers | Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death | Pharmacology

To discover novel cytotoxic CG scaffolds, we selected the cardenolide glucoevatromonoside (GEV) out of 46 CGs for its low ... To discover novel cytotoxic CG scaffolds, we selected the cardenolide glucoevatromonoside (GEV) out of 46 CGs for its low ... Cardenolides and Chemicals. The origin of all tested cardenolides is indicated in Supplementary Table 1. Compounds were ... 2006). The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small ...
more infohttps://www.frontiersin.org/articles/10.3389/fphar.2018.00070/full

Asclepias - WikipediaAsclepias - Wikipedia

Milkweed is named for its milky sap, which consists of a latex containing cardiac glycosides termed cardenolides. Most species ... Milkweeds use three primary defenses to limit damage caused by caterpillars: hairs on the leaves, cardenolide toxins, and latex ... Singh, B. and Rastogi, R.P. (1970). Cardenolides-glycosides and genins. Phytochemistry 9: 315-331. Agrawal, Anurag (2017-03-07 ... "Toxic cardenolides: chemical ecology and coevolution of specialized plant-herbivore interactions". New Phytologist. 194 (1): 28 ...
more infohttps://en.wikipedia.org/wiki/Asclepias

Cardiac glycoside - WikipediaCardiac glycoside - Wikipedia

For example, cardenolides have been primarily derived from the foxglove plants Digitalis purpurea and Digitalis lanata, while ... Plants from which cardenolides can be derivedEdit. *Convallaria majalis (Lily of the Valley): convallotoxin[7] ... Cardenolides differ from bufadienolides due to the presence of an "enolide," a five-membered ring with a single double bond, at ... cardenolides are more commonly used medicinally, primarily due to the widespread availability of the plants from which they are ...
more infohttps://en.m.wikipedia.org/wiki/Cardiac_glycoside
  • Each of the 6 cardenolides deterred feeding by S. littoralis , while two cardenolide standards, digoxin and digitoxin, did not affect feeding. (springer.com)
  • Their cytotoxicity and the underlying mechanistic signaling axes have been extensively documented, but only a few anti-viral activities of cardenolides and the associated signaling pathways have been reported. (bioportfolio.com)
  • Compound 1 was the first cardenolide isolated from Tupistra chinensis and exhibited potent cytotoxicity against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. (kib.ac.cn)
  • The cardenolide ouabain suppresses coronaviral replication via augmenting a Na/K-ATPase-dependent PI3K_PDK1 axis signaling. (bioportfolio.com)
  • Ouabain, a representative cardenolide, was found to potently diminish TGEV titers and inhibit the TGEV-induced production of IL-6 in a dose dependent manner, with 50% inhibitory concentrations of 37 nM and 23 nM respectively. (bioportfolio.com)
  • When tested in a xenograft model of retinoblastoma, the cardenolide ouabain induced complete tumor regression in the treated mice. (arvojournals.org)
  • For example, cardenolides have been primarily derived from the foxglove plants Digitalis purpurea and Digitalis lanata , while bufadienolides have been derived from the venom of the cane toad Bufo marinus , from which they receive the "bufo" portion of their name. (wikipedia.org)
  • Activity-guided fractionation of the methanol extracts of G. sinaicus and P. tomentosa resulted in the isolation of six cardenolides: 7,8-dehydrocalotropin, calotropin and coroglaucigenin 3-(6-deoxy-β-allopyranoside)-19-acetate (frugoside 19-acetate) from G. sinaicus , and coroglaucigenin, 16α-acetoxycalotropin and calactin from P. tomentosa . (springer.com)
  • led to the isolation of 2 cardenolides, strophanthidin 1, and helveticoside 2, where the latter demonstrated potent activity against 6 cell lines tested, especially A-549 [human lung carcinoma]. (who.int)
  • The observed feeding deterrent activity of the cardenolide-free methanol extract of C. acutum would suggest that compounds other than cardenolides are responsible for the deterrent activity. (springer.com)
  • Caspase-3 activation studies provided an insight into the mechanism of action of cardenolides in retinoblastoma cells. (arvojournals.org)
  • The aim of the present work was therefore to investigate whether the partial inhibition of the sodium pump activity in human glioblastoma cells by the UNBS1450 cardenolide (Van Quaquebeke et al. (aacrjournals.org)
  • The data from the present study thus show that the use of a cardenolide (UNBS1450) that binds to the sodium pump and therefore markedly impairs Src- and EGF-R-related signalling pathways could be added to the limited set of drugs aiming to efficiently combat glioblastoma. (aacrjournals.org)
  • The binding of cardenolides to the sodium pump causes rapid modifications in the levels of Src family kinase activity and therefore in those of EGF-R because the sodium pump, Src and EGF-R are partners in a cellular compartment named the sodium pump signalosome. (aacrjournals.org)
  • Differences among cardenolides in their effect on feeding were associated with specific structural features. (springer.com)
  • Cardenolides were identified as a new class of antitumor agents for the treatment of retinoblastoma. (arvojournals.org)