A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
Tumors or cancer of the UTERUS.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)
A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)
Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.
Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)
A malignant tumor composed of more than one type of neoplastic tissue. (Dorland, 27th ed)
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Oxygenated forms of carotenoids. They are usually derived from alpha and beta carotene.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
A subspecialty of internal medicine concerned with the study of neoplasms.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A usually benign tumor made up predominantly of myoepithelial cells.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
MAMMARY GLANDS in the non-human MAMMALS.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.
A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.
Tumors or cancer of the THYROID GLAND.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
Systematic study of the body and the use of its static and dynamic position as a means of communication.
Excision of the uterus.
A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.
Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.
Tumors or cancer of the LUNG.
A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Any hindrance to the passage of air into and out of the lungs.
A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Antibodies produced by a single clone of cells.

Walker 256/S carcinosarcoma causes osteoporosis-like changes through ectopical secretion of luteinizing hormone-releasing hormone. (1/191)

We have shown that Walker 256/S mammary carcinoma caused osteoporosis-like changes in young female rats, accompanied by low serum estradiol and hypercalciuria without changes in the serum levels of calcium, phosphorus, and parathyroid hormone-related peptide. In this study, we investigated the cause of bone loss after Walker 256/S inoculation into female 6-week-old Wistar Imamichi rats, focusing on the sex hormone balance in the host animal. Walker 256/S-bearing rats showed characteristic osteoporosis, with a significant increase in spleen weight and a significant decrease in uterine weight by 14 days after s.c. tumor inoculation. In the in vitro bone marrow culture, mineralized nodule formation ability decreased according to the time after tumor inoculation, and tartrate-resistant acid phosphatase-positive multinucleated cell formation increased at 7 days after tumor inoculation, but it began to decrease at 14 days after tumor inoculation. This indicates that after inoculation with Walker 256/S tumor, the progenitors of osteoblasts and ostroclasts lost their balance in the bone turnover, resulting in bone resorption. On the other hand, Walker 256/S carcinoma expressed luteinizing hormone-releasing hormone (LH-RH) mRNA, and in Walker 256/S-bearing rats, the serum LH-RH level increased significantly from 3 days after tumor inoculation, whereas in the healthy control rats, this level was very low. Consequently, the serum levels of follicle-stimulating hormone, luteinizing hormone, estradiol, and progesterone were significantly lower in the tumor-bearing rats than in the healthy control rats. Because the LH-RH gene is located in the long prolactin release-inhibiting factor (PIF) gene and mRNA amplified by reverse transcription-PCR in this study contained whole LH-RH and a part of PIF, the Walker 256/S tumor is thought to express PIF. Indeed, the serum prolactin level decreased in tumor-bearing rats. The serum level of growth hormone, one of the other pituitary hormones, was not changed. Moreover, the level of an osteolytic cytokine, tumor necrosis factor alpha, increased in the serum of Walker 256/S-bearing rats, although this may be a result of the immune response of the host animal to tumor growth as well as an enlarged spleen. In conclusion, the Walker 256/S tumor lowers estrogen secretion through ectopical oversecretion of LH-RH, and then osteolytic cytokines, such as tumor necrosis factor alpha, increase in tumor-bearing rats, escape the control of estrogen, and activate osteoclasts, resulting in bone loss in a short period.  (+info)

Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles. (2/191)

As part of a study of the effects of low-level radiation, 1,343 Beagles, including 671 males and 672 females, were evaluated over their full lifetime for the occurrence of mammary neoplasia; there were 139 control males and 138 control females and 532 irradiated males and 534 irradiated females. All nodules found in surgical specimens or at necropsy were evaluated histologically. The overall incidence, metastasis and recurrence rates, and contribution to mortality of mammary neoplasms were determined. Based on this unique opportunity to correlate morphologic characteristics with ultimate biological behavior of all mammary tumors in a defined canine population, we propose a histogenetically based reclassification of epithelial mammary tumors. Of the 672 female dogs, 70.8% (476) had at least one mammary neoplasm; 60.7% (408) had more than one. Two male dogs had mammary neoplasms. Of 1,639 mammary carcinomas in the 672 females, 18.7% (307) were classified as ductular carcinomas (arising from the small interlobular or intralobular ductules), whereas 80.7% (1,322) were classified as adenocarcinomas of other histogenetic origin. Of 73 fatal carcinomas, ductular carcinomas accounted for 48 fatalities (65.8%), whereas other adenocarcinomas accounted for only 20 fatalities (27.4%). Radiation had no effect on this ratio. Ductular carcinomas also had a higher rate of metastasis than did adenocarcinomas. Existing classifications of mammary carcinomas do not recognize the characteristic morphologic features, the degree of malignancy, and the prognostic importance of these ductular carcinomas. Metastasis rates did not differ between simple and complex carcinomas or between those lesions and adenocarcinomas in mixed tumors. True carcinosarcomas metastasized more frequently (100%, or 5/5) than did adenocarcinomas in mixed tumors (34.4%, or 22/64), emphasizing the importance of not lumping these tumors under the classification of malignant mixed tumors.  (+info)

Increased expression of ornithine decarboxylase messenger RNA in human esophageal carcinoma. (3/191)

Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. The purpose of this study was to evaluate ODC expression in human esophageal cancer at the mRNA level. Sixty-four pairs of primary esophageal cancers and normal esophageal epithelia were examined by reverse transcription-PCR for ODC mRNA expression. The ODC mRNA levels were higher in primary esophageal carcinoma than in adjacent normal esophageal epithelium in 58 (90.6%) of 64 cases. The tumor:normal (T:N) ratio of ODC mRNA expression in esophageal specimens has a significant correlation with tumor-node-metastasis staging (P = 0.043), lymph node metastasis (P = 0.039), vascular vessel invasion (P = 0.035), and histology (P = 0.034) of the tumor. In well- and moderately differentiated squamous cell carcinoma, the patients with a higher T:N ratio showed a significantly poorer prognosis (P = 0.027), and multivariate analysis also confirmed that the T:N ratio has a significant correlation with poor prognosis (P = 0.043). The steady-state of ODC mRNA overexpression in esophageal carcinoma implies that the ODC gene may play an important role in tumorgenesis in squamous epithelium. Furthermore, ODC mRNA expression may be used as a prognostic marker, especially for well- and moderately differentiated squamous cell carcinoma.  (+info)

Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. (4/191)

Carcinosarcomas of the uterus, ovaries, and fallopian tubes are highly aggressive neoplasms with incompletely understood histogenesis. Although recent immunohistochemical, cell culture, and molecular genetic studies all favor these cancers to be monoclonal in origin, the extent of intratumoral genetic heterogeneity in these tumors with divergent histology has not been reported previously. For this study, we microdissected a total of 172 carcinomatous or sarcomatous foci from 17 gynecological carcinosarcomas and analyzed allelic status with 41 microsatellite markers on chromosomal arms 1p, 1q, 3p, 4q, 5q, 6q, 8p, 9p, 10q, 11p, 11q, 13q, 16q, 17p, 17q, 18q, and 22q. With the exception of a single case with microsatellite instability, we found shared allelic losses and retentions among multiple individually dissected foci of each case, strongly supportive of the concept of a monoclonal origin for these neoplasms. In eight of these cases, we also found heterogeneous patterns of allelic loss at limited numbers of chromosomal loci in either the carcinomatous or sarcomatous components of the neoplasms. These heterogeneous patterns of allelic losses were consistent with either genetic progression or genetic diversion occurring during the clonal evolution of these neoplasms. In two cases, we found the specific patterns of genetic progression to be consistent with sarcomatous components of the neoplasms arising from carcinomatous components. We conclude that most of the gynecological carcinosarcomas have a monoclonal origin, and that genetic progression and diversion parallel the development of divergent phenotypes in these tumors. Because phenotypically divergent areas of the tumors share numerous genetic alterations, this divergence most likely occurs relatively late in the evolution of these tumors.  (+info)

Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. (5/191)

Neoplasms with mixed carcinomatous and sarcomatous growth patterns occur in many organs and tissues. The pathogenesis of these cancers is thought to be either the result of two independent neoplastic processes merging to form a single tumor, or a neoplasm of monoclonal origin that develops phenotypic diversity. To address this issue, we characterized molecular alterations in separately microdissected epithelial and sarcomatous areas in three cases of pancreatic mucinous cystic neoplasms with sarcomatous stroma. Using microsatellite markers for six chromosomal loci commonly deleted in infiltrating ductal adenocarcinomas of the pancreas, we found genetic alterations to be virtually identical between the sarcomatous and epithelial components of two of the three neoplasms. In the third neoplasm, we found allelic losses and retentions to be identical at five of the six chromosomal loci, but at a single locus, we noted allelic loss in the neoplastic epithelial component but not the sarcomatous component. The same neoplasms were also analyzed for activating point mutations in codon 12 of the K-ras gene by using mutant-enriched polymerase chain reaction and allele-specific oligonucleotide hybridization. A K-ras mutation was identified in the epithelial component of one of the three neoplasms (the same tumor with an additional allelic loss in the neoplastic epithelial cells), but the sarcomatous component of this tumor was wild-type at codon 12 of K-ras, as were both components of the other two neoplasms. Overall, these results suggest a monoclonal origin with subsequent divergence of the neoplastic epithelial and sarcomatous portions of these neoplasms.  (+info)

A so-called carcinosarcoma of the gallbladder in a patient with multiple anomalies--a case report. (6/191)

The patient was a 65-year-old woman with a chief complaint of right upper quadrant pain. Under the diagnosis of gallbladder tumor, preduodenal portal vein and absence of the pancreatic tail, cholecystectomy was performed. Intraoperative findings resulted in a diagnosis of gallbladder tumor, absence of the pancreatic tail, presence of preduodenal portal vein, and malrotation of the intestine. Histological examination of the resected specimens showed a so-called carcinosarcoma. Carcinosarcoma of the gallbladder is a rare tumor of the hepatobiliary region. The present case differs from previously reported cases in its presentation with multiple anomalies including the presence of preduodenal portal vein. Many cases of preduodenal portal vein in an association with duodenal stenosis in children have been reported, but reports of cases of preduodenal portal vein in adult patients are rarely seen in the literature.  (+info)

A case report of sinonasal teratocarcinosarcoma. (7/191)

A sinonasal teratocarcinosarcoma (SNTCS) is a rare and aggressive malignant neoplasm histologically characterized by the combination of one or more epithelial elements and mesenchymal components. We report a case of a 78-year-old man with SNTCS involving the nasal cavity and paranasal sinuses. He complained of epiphora and exophthalmos with weight loss. Physical and diagnostic images resulted T4N0M0. The tumor was completely and widely resected via a trans-facial approach to perform total maxillectomy with orbital exenteration. The clinical presentation, pathologic features, and clinical course are described with a review of the literature.  (+info)

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. (8/191)

Adult, embryonic, and tumor tissues were grafted to the chorioallantoic membrane of the chick embryo to determine whether blood vessels originally within implants were reused in the establishment of a new blood supply. Grafts were examined daily by in vivo stereomicroscopy and in histologic sections. Colloidal carbon injections into the host vasculature served to confirm the precise onset of graft circulation; Preexisting tumor blood vessels disintegrated by 24 hours after implantation and revascularization occurred at 3 days by penetration of proliferating host vessels into the tumor tissue. Adult tissues did not revascularize, and the original graft vasculature progressively disintegrated during the 9 days of observation, Most embryonic tissues revascularized in 1 or 2 days by reperfusion of the existing graft vasculature. Anastomosis of host and graft blood vessels seemed to result from connections between newly formed vascular sprouts arising from both vasculatures. This study indicates that only tumor grafts acquire their blood supply solely by formation of new blood vessels from the host microvasculature. By contrast revascularization of normal tissues, when it does occur, is predominately the result of perfusion of the preexisting graft blood vessels.  (+info)

TY - JOUR. T1 - Carcinosarcoma in the cecum. AU - Ryu, Youngjoon. AU - Kim, Aeree. AU - Kim, Han Kyeom. AU - Lee, Beomjae. AU - Jung, Woonyong. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. AB - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. KW - ...
TY - JOUR. T1 - Polypoid or non-polypoid? A novel dichotomous approach to uterine carcinosarcoma. AU - Djordjevic, B.. AU - Gien, L. T.. AU - Covens, A.. AU - Malpica, A.. AU - Khalifa, M. A.. N1 - Copyright: Copyright 2009 Elsevier B.V., All rights reserved.. PY - 2009/10. Y1 - 2009/10. N2 - Objective. To examine the impact of the polypoid morphology of uterine carcinosarcoma on clinical outcome, as well as its relationship to well-established prognostic factors. Methods. In a retrospective study of fifty eight patients with uterine carcinosarcoma treated with hysterectomy, we correlated the polypoid status of tumors with stage, lymphatic vascular invasion, myometrial invasion, size, carcinoma to sarcoma ratio, type of carcinomatous and sarcomatous components, disease free survival and overall survival. Results. By multivariate analysis, the polypoid status had no impact on disease free survival (p = 0.8958), but approached significance as a positive predictor for overall survival (p = 0.0569); ...
TY - JOUR. T1 - Co-expression of GPR30 and ERβ and their association with disease progression in uterine carcinosarcoma. AU - Huang, Gloria S.. AU - Gunter, Marc J.. AU - Arend, Rebecca C.. AU - Li, Maomi. AU - Arias-Pulido, Hugo. AU - Prossnitz, Eric R.. AU - Goldberg, Gary L.. AU - Smith, Harriet O.. PY - 2010/9. Y1 - 2010/9. N2 - Objective: We sought to evaluate the expression of G protein-coupled receptor 30 (GPR30) and estrogen receptor (ER)β in uterine carcinosarcoma (CS). Study Design: Immunohistochemistry was performed using antibodies to GPR30, ERβ, ERα, and progesterone receptor (PR). The staining intensity and percentage of positive cells were scored for each tissue section. Expression levels were compared using the Wilcoxon rank sum test. Correlation was evaluated by Spearman rho and logistic regression. Results: Compared with normal endometrium, CS had lower ERα and PR expression (both P , .01) but higher GPR30 epithelial expression (P = .03). Advanced-stage CS had higher GPR30 ...
To examine the effect of the histology of carcinoma and sarcoma components on survival outcome of uterine carcinosarcoma. A multicenter retrospective study was conducted to examine uterine carcinosarcoma cases that underwent primary surgical staging. Archived slides were examined and histologic patterns were grouped based on carcinoma (low-grade versus high-grade) and sarcoma (homologous versus heterologous) components, correlating to clinico-pathological demographics and outcomes. Among 1192 cases identified, 906 cases were evaluated for histologic patterns (carcinoma/sarcoma) with high-grade/homologous (40.8%) being the most common type followed by high-grade/heterologous (30.9%), low-grade/homologous (18.0%), and low-grade/heterologous (10.3%). On multivariate analysis, high-grade/heterologous (5-year rate, 34.0%, P = 0.024) and high-grade/homologous (45.8%, P = 0.017) but not low-grade/heterologous (50.6%, P = 0.089) were independently associated with decreased progression-free survival ...
I JUST found my childhood friends post on Facebook telling me she is having a total hysterectomy today for Uterine Carcinosarcoma and Im heartbroken. I lost one schoolmate about 10 years ago to brain cancer (same as her Mom had died from about 10 years before her). And Ive had several friends at work have cancer, some have died. Ive had another childhood friend how battled breast cancer, a daughter-in-law who had a tonsil become cancerous about 10 years ago which is survived and continues to be cancer free today. I have just been reading everything I can on this horrible uterine cancer. There is no history in my own family of cancer at all but Im terrified, for my friend today having surgery and for myself.. Im now wondering if I might better have a hysterectomy as well. I have a very large uterus caused by 3 huge fibroids... but since there is no cancer in my family, Ive thought it okay to put off a hysterectomy and wait for menopause to shrink them down. Ive been in menopause for 3-4 ...
Uterine carcinosarcomas (previously called malignant mixed Müllerian tumors) are dedifferentiated (metaplastic) carcinomas comprised of carcinomatous and sarcomatous elements arising from a single malignant clone. They may represent a stable disrupti
Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries. Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, based on the observation that skin cancers and superficial malignant fibrous histiocytomas are commonly seen in patients with sun-damaged skin; second, the composition hypothesis, which suggests that the mesenchymal component represents a pseudosarcomatous reaction to the epithelial malignancy; third, the combination hypothesis, which suggests that both the epithelial and mesenchymal components of the tumor arise from a common ...
Herein we report a carcinosarcoma with distinct epithelial and mesenchymal components, at the morphological, immunohistochemical and ultrastructural levels. Moreover, the sarcomatous component was composed of cells reminiscent of smooth muscle differentiation and cells with osteoblastic appearance. Some authors classified as large bowel carcinosarcomas epithelial tumours with areas of sarcomatoid differentiation, weakly immunoreactive for cytokeratins and with no evidence of osteosarcomatous nor chondrosarcomatous differentation [12, 13, 20, 21]. According to Aramendi et al., these cases are not properly carcinosarcomas, but should be considered sarcomatoid poorly differentiated carcinomas [23]. In the present case, the sarcomatous component completely lacked any epithelial signs of differentiation; furthermore, we noted areas of osteosarcomatous differentiation and osteoid material deposition. The topographic distribution was remarkable for the complete separation of the two components. ...
Carcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. They are most commonly seen in the female genital tract. Rarely they arise from the gastrointestinal tract. We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. The most unique feature of this tumour is the presence of osteosarcomatous element. This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma ...
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components. Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1...
Sarcomatoid carcinoma, or carcinosarcoma, is a neoplasm that contains both sarcomatous and carcinomatous elements. It is an extremely rare cancer most often arising from visceral organs. Here we report the seventh documented de novo case of carcinosarcoma of the bone, in a young female who showed initial clinical improvement with gemcitabine and docetaxel. A 36-year-old Caucasian female presented with diffuse musculoskeletal pain that had progressed from her shoulder to her back, arm, and knee over 6 months. Imaging revealed diffuse sclerotic lesions of bilateral humeral heads, iliac and ischial bones, and thoracic and lumbar spine. Histopathologic examination of biopsies from the T9 vertebra and left femur showed mainly sarcomatous spindle cells with focal osteoid production. Immunostaining showed the cells to be OSCAR cytokeratin, patchy positive for pankeratin, and negative for CK7, GATA3, S100, SOX10, CD99, EMA, AE1/AE3, and HMW keratin indicative of an epithelial origin. After thorough clinical
PRIMARY OBJECTIVES:. I. To assess the one year recurrence-free survival in patients with uterine carcinosarcoma treated with sandwich therapy-including defining the patterns of recurrence in patients with carcinosarcoma who were treated with this regimen.. II. To evaluate the toxicity and tolerability of pelvic radiation sandwiched between cycles of paclitaxel/carboplatin chemotherapy in patients with uterine carcinosarcoma.. III. To correlate surrogate endpoint biomarkers with progression-free survival and prognosis.. OUTLINE:. CHEMOTHERAPY (weeks 1-9, 14-22): Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 3 courses during weeks 1-9 and 14-22.. RADIATION THERAPY (weeks 8-16): Patients undergo external beam pelvic radiation therapy once a day, 5 days a week for 5 weeks during weeks 8-13. Patients then undergo high dose radiation (HDR) brachytherapy or intensity-modulated radiation therapy (IMRT) ...
BACKGROUND Carcinosarcoma of the sinonasal tract is an extremely rare malignant neoplasm; it is often designated as carcinoma with spindle cell or sarcomatoid features. We report a case of carcinosarcoma arising in a pre-existing inverted Schneiderian papilloma in the left maxillary antrum and nasal cavity of a 72-year old male patient. CASE REPORT The patient had a significant history of radiotherapy for squamous cell carcinoma in the sinonasal area, 3 decades ago. The patient presented with chief complaints of left nasal blockage, nasal discharge, anosmia, and occasional epistaxis. Computed tomography scan displayed a lobular soft tissue mass resulting in narrowing of the nasopharyngeal airway with massive destruction of palatal tissue. The lesion was resected via endoscopic surgery. Macroscopically, a white fleshy appearance with necrosis was noted in the submitted specimen. Microscopically, the tumor was composed of pleomorphic epithelial and spindle cells with numerous mitoses and ...
TY - JOUR. T1 - Carcinosarcoma of bladder following long-term cyclophosphamide therapy. AU - Sigal, S. H.. AU - Tomaszewski, J. E.. AU - Brooks, J. J.. AU - Wein, A.. AU - LiVolsi, V. A.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkins lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period.. AB - Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell ...
Results: The median age of the entire cohort was 65 years (range; 39-82). All patients underwent both pelvic and paraaortic lymphadenectomy. Forty-one patients received adjuvant therapy. The median follow-up time was 24 months (range; 1-129). Nineteen (27.1%) patients had disease failure. The 3-year disease-free survival and cancer-specific survival of the entire cohort was 67% and 86%, respectively. In the univariate analysis, only age was significantly associated with disease-free survival (p=0.022). There was no statistical significance for disease-free survival between observation and receiving any type of adjuvant therapy following staging surgery. Advanced age (,75 vs ≥75 years) was the only independent prognostic factor for recurrence (hazard ratio: 3.8, 95% CI=1.10-13.14, p=0.035) in multivariate analysis. None of the factors were significantly associated with cancer-specific survival ...
In my earlier response I mentioned that I had received Ifosfamide and Adriamycin (Doxorubicin) as phase 2 of my chemotherapy treatment. Since Ifosfamide can cause serious bladder problems, my medical oncologist admitted me as an inpatient for three days for each of these four cycles. I received the Ifosfamide over the three days, along with Mensa - a drug to help prevent bladder damage. I also received fluids to flush the chemo from my kidneys during the entire stay. And my urine was checked every time I went to the bathroom to make sure there was no blood (there never was).. I actually felt fine in the hospital and was able to work on my computer, visit with family and friends, etc. The day after I got home I also gave myself a Neulasta shot to reduce the chance of infections.. While I never had any reaction to the Neulasta shot, I did feel absolutely horrible a few days after I got home from the first hospital stay. I frankly wasnt sure I could continue with this regimen, given how bad I ...
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process ...
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process ...
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old man was operated on for a polypoid tumor of the distal esophagus. Histologically, this tumor was composed of ductal structure
Rare Cancer News & Clinical Trials » Trial - Sarcoma » Paclitaxel/Carboplatin + Galunisertib for Patients With Carcinosarcoma of the Uterus or ...
Renal carcinosarcoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
TY - JOUR. T1 - Sarcomatoid carcinoma of the thymus - A case report. AU - Hsu, N. Y.. AU - Chen, C. Y.. AU - Kwang, P. C.. AU - Hsu, C. P.. AU - Hsia, J. Y.. PY - 1996. Y1 - 1996. N2 - A 20-year-old female with a sarcomatoid carcinoma of the thymus invading the left upper lobe of the lung was treated with surgical reaction and adjuvant radiotherapy. We report a case of this rare histologic variant of thymic carcinoma and review the literature.. AB - A 20-year-old female with a sarcomatoid carcinoma of the thymus invading the left upper lobe of the lung was treated with surgical reaction and adjuvant radiotherapy. We report a case of this rare histologic variant of thymic carcinoma and review the literature.. KW - carcinosarcoma. KW - sarcomatoid carcinoma. KW - thymus neoplasms. UR - http://www.scopus.com/inward/record.url?scp=0030425222&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030425222&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0030425222. VL - 30. SP - ...
WASHINGTON -- Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database suggested.
Uterine sarcoma (US) is a general term referring to rare malignancies of the uterus that originate from mesenchymal cells. US differ with regards to their histological features, growth behavior and response to therapy. Uterine carcinosarcoma, a type of mixed epithelial and mesenchymal tumor, is most frequently diagnosed. The most common uterine malignancy of solely mesenchymal origin is leiomyosarcoma. The identification of US on the basis of imaging results poses a major challenge. Therefore, many patients undergo surgery for presumed benign disease, such as leiomyoma, and the true type of tumor is only recognized after the histological examination of resected tissues.… Uterine Sarcoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Objective: Uterine carcinosarcoma (UCS) is an aggressive malignancy, making up less than 5% of uterine cancers. Pharmacologic inhibition of ATR kinase synergistically enhances the ability of cisplatin to kill carcinoma cells of many solid tumor types and is further enhanced in ATM low carcinoma cells. It is unknown whether ATR inhibition (ATRi) offers a therapeutic opportunity in UCS. The goal of this study was to evaluate ATM expression in UCS tumors and determine the response of an ATM low UCS model to ATRi + cisplatin combination.. Methods: ATM expression was evaluated in full tissue sections from 74 UCS tumors by immunohistochemistry (IHC) with an ATM specific monoclonal antibody (clone Y170, Abcam), and was categorized as negative vs any positive staining in the carcinomatous (C) vs sarcomatous (S) components. In vitro models of UCS: SK-UT-1, SK-UT-1B, KLE, and RL95-2 cell lines were treated with an ATRi (AZD6738), cisplatin, and ATRi + cisplatin. ATM low models were generated in RL95-2 ...
Hepatocellular carcinoma Neoplasm of ovary Small cell lung cancer Renal cell carcinoma Malignant melanoma of skin Papillary renal cell carcinoma, sporadic Carcinoma of gallbladder Colorectal Neoplasms Ovarian Neoplasms Ovarian Serous Cystadenocarcinoma Adenocarcinoma of prostate Squamous cell carcinoma of lung Glioblastoma Transitional cell carcinoma of the bladder Uterine Carcinosarcoma Pancreatic adenocarcinoma Adenocarcinoma of lung Uterine cervical neoplasms Squamous cell carcinoma of the head and neck Neoplasm of breast Adenocarcinoma of stomach Neoplasm of brain Malignant neoplasm of body of uterus Brainstem glioma Oesophageal carcinoma Nasopharyngeal Neoplasms Carcinoma of colon Epidermal nevus Malignant melanoma ...
Squamous cell carcinoma of the head and neck Adenocarcinoma of stomach Ovarian Serous Cystadenocarcinoma Neoplasm of brain Glioblastoma Colorectal Neoplasms Uterine Carcinosarcoma Transitional cell carcinoma of the bladder Oesophageal carcinoma Adenocarcinoma of prostate Pancreatic adenocarcinoma Hepatocellular carcinoma Adenocarcinoma of lung Neoplasm of breast Squamous cell carcinoma of lung Brainstem glioma not provided Li-Fraumeni syndrome 1 Hereditary cancer-predisposing syndrome Li-Fraumeni syndrome ...
© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. The objective of this study was to investigate the relationship of insulin-like growth factor 2 (IGF2) expression and survival in women with uterine carcinosarcoma (UCS). Insulin-like growth factor 2 protein expression was determined by immunohistochemical staining of tumor tissues from 103 patients with UCS. The H-score (product of staining intensity and percentage positive cells) was quantified for the epithelial cytoplasmic (EC), epithelial nuclear (EN), and malignant stromal compartments. Multivariable Cox proportional hazard regression models were used to examine the relationship of IGF2 levels with progression-free survival (PFS) and overall survival (OS). Adjusting for stage, race, and adjuvant therapy, PFS and OS were reduced in patients with high IGF2 (H-score ≥ median) in the EC and EN compartments. Black race was independently associated with reduced PFS and OS in patients with early-stage disease, and IGF2 levels in
A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma Academic Article ...
Matsuo, K.;Takazawa, Y.;Ross, M.S.;Elishaev, E.;Podzielinski, I.;Yunokawa, M.;Sheridan, T.B.;Bush, S.H.;Klobocista, M.M.;Blake, E.A.;Takano, T.;Matsuzaki, S.;Baba, T.;Satoh, S.;Shida, M.;Nishikawa, T.;Ikeda, Y.;Adachi, S.;Yokoyama, T.;Takekuma, M.;Fujiwara, K.;Hazama, Y.;Kadogami, D.;Moffitt, M.N.;Takeuchi, S.;Nishimura, M.;Iwasaki, K.;Ushioda, N.;Johnson, M.S.;Yoshida, M.;Hakam, A.;Li, S.W.;Richmond, A.M.;Machida, H.;Mhawech-Fauceglia, P.;Ueda, Y.;Yoshino, K.;Yamaguchi, K.;Oishi, T.;Kajiwara, H.;Hasegawa, K.;Yasuda, M.;Kawana, K.;Suda, K.;Miyake, T.M.;Moriya, T.;Yuba, Y.;Morgan, T.;Fukagawa, T.;Wakatsuki, A.;Sugiyama, T.;Pejovic, T.;Nagano, T.;Shimoya, K.;Andoh, M.;Shiki, Y.;Enomoto, T.;Sasaki, T.;Fujiwara, K.;Mikami, M.;Shimada, M.;Konishi, I.;Kimura, T.;Post, M.D.;Shahzad, M.M.;Im, D.D.;Yoshida, H.;Omatsu, K.;Ueland, F.R.;Kelley, J.L.;Karabakhtsian, R.G.;Roman, L.D. Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma. Annals ...
Los pacientes con tumores ampulares que no fueron operados por ejemplo, aquellos con enfermedad diseminada fueron excluidos. El objetivo final primario fue la sobrevida global.. Este estudio fue aprobado por el Committee on Human Research at University of California, San Francisco y se obtuvo un consentimiento informado. Los tumores en anillo de sello y los carcinosarcomas no fueron asignados a un subtipo tumoral. C Adenocarcinoma tipo intestinal de la ampolla.. El resto fueron carcinomas mucinosos en anillo de sello 4 tumores , carcinosarcoma 1 tumor o indeterminados 6 tumores. Otras presentaciones, edad sexo y raza no fueron predictivas de la sobrevida del paciente. Kimura y col. Chu y col. Beger y col. Talamini y col. Howe y col.. En muchos tumores, el fenotipo no fue uniforme. Adsay y col. Los adenocarcinomas de tipo intestinal se originan de la mucosa duodenal que recubre la ampolla en una secuencia adenoma-displasia-adenocarcinoma y son menos agresivos. Kim R. J Am Coll Surg Howe J. Ann ...
A malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat). Can appear in uterine, ovarian, pancreatic locations. Also known as Mixed Mullerian Tumor.
Of 224 patients entered on this study, 30 were ineligible for a variety of reasons, leaving 194 evaluable patients. Early in the study, the dose of the combination regimen was reduced by 20% (1 day) because of toxicity. The investigational arms were balanced for age, grade, and Gynecologic Oncology Group performance status. Percentages of adverse effects reported in 191 patients receiving chemotherapy included (ifosfamide/cisplatin-ifosfamide) grade 3 or 4 granulocytopenia (36/60), grade 3 or 4 anemia (8/17), grade 3 or 4 central nervous system toxicity (19/14), and grade 3 or 4 peripheral neuropathy (1/12). Treatment may have contributed to the deaths of 6 patients treated with full doses of ifosfamide and cisplatin for 5 days. The proportion of patients responding to ifosfamide alone versus ifosfamide-cisplatin therapy was (0.36 versus 0.54) overall, 0.47 versus 0.61 for pelvic, 0.21 versus 0.54 for lung, and 0.33 versus 0.40 for other metastatic sites of measurable disease. The relative ...
The International Agency for Research on Cancer recently estimated that endometrial carcinoma is the commonest gynaecological cancer in the developed world,1 with a rising incidence in postmenopausal women. In 2007, 7536 new endometrial cancers were diagnosed in the UK, making it the fourth most common cancer in women after breast, lung, and colorectal cancers.2 Cancer of the endometrium is the commonest cancer of the uterine corpus (about 92%, the remainder being uterine carcinosarcomas and sarcomas), according to the Surveillance, Epidemiology and End Results programme of the US National Cancer Institute, which has collected data on cancer from various locations and sources since 1973.3 Cure is possible and the overall five year survival rate for all stages is currently around 80%. Most women present early in the course of the disease when cure is more likely, so primary care practitioners need to be vigilant for potential indicators. We discuss the epidemiology, diagnosis, and treatment of ...
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About a week later I visited a local gynocologist. With only the written ultrasound analysis in front of her and an external poke-around exam, the gyn told me that the ovary needed to be taken out immediately and at my age, I didnt need the rest. She wanted to admit me for surgery four days later to do a total abdominal hysterectomy, and while I was on the operating table, the tissues would be sent to pathology. If any cancer was found, fatty tissue and lymph nodes would be removed, with the assistance of an attending local gyn-oncologist. She offered a prescription for Xanax. I demurred, saying that my husband and I had planned a weekend getaway - couldnt I do that - and that I would seek a second opinion at University of Pennsylvania. She reluctantly agreed, and the slight body language response suggested that I had slapped her in the face. For the interim, she ordered a CT scan and CA125 blood test, which I obtained right away ...
Sarcomatoid carcinomas of the lung are very uncommon tumors and their biological behavior remains controversial. Here we describe a case of a 62 year old male with an endobronchial mass and subjected thereafter to right upper and middle bilobectomy. A squamous carcinoma with a sarcomatous component resembling a fibrosarcoma was found at microscopic examination. Although there is neither agreement on the denomination nor on the histogenesis of these tumours, it is recognized that they are highly aggressive. Therefore, in order to provide the best possible treatment it appears recommendable to supply a detailed description of the different components of the tumor at the time of the histopathological diagnosis ...
Throughout the reported case, we found recurrence within 2 months, and tumor progression was very rapid. However, there were no cases that progressed as rapidly as shown in our case. The cases reported so far mostly presented a polypoid pattern of the tumor in the CT or the pathology of the removed specimen (7 of 10 cases). Alternatively, in the present case, the tumor was flat on the bile duct and tumor growth showed an infiltrative pattern, usually shown in gallbladder carcinosarcoma. An infiltrative pattern may have poor prognosis compared with a polypoid pattern because polypoid types tend to arise earlier with obstruction of the bile duct and obstructive symptoms, which enable easier detection [14]. The present case shows very radical progression, thus having the possibility that multiple small hidden malignancies would go undetected preoperatively, as well as the histochemical features of a tumor, especially sarcomatoid cells, associated with poor prognosis. There are few references which ...
Historically, about 50 percent of mammary tumors in dogs were found to be malignant,[9] although taking into account tumor behavior, one study has estimated true malignancy in mammary tumors to be 21 to 22 percent.[6] Adenomas and fibroadenomas make up the benign types. Malignant mammary tumors are divided into sarcomas, carcinosarcomas, inflammatory carcinomas (usually anaplastic carcinomas), and carcinomas (including adenocarcinomas), which are the most common.[9] Inflammatory carcinomas describe tumors that are fast growing and have bruising, edema, and pain, and can also cause disseminated intravascular coagulation. They are the most malignant type of canine mammary tumor.[10] Malignant tumors are also subdivided histopathologically into those showing blood vessel wall invasion and those that do not. Without blood vessel wall invasion there is a better prognosis.[11] Dogs with noninvasive adenocarcinomas have an average survival time of two years, while dogs with invasive adenocarcinomas ...
Torenbeek, R., Hermsen, M.A., Meijer, G.A., Baak, J.P. and Meijer, C.J. (1999) Analysis by Comparative Genomic Hybridization of Epithelial and Spindle Cell Components in Sarcomatoid Carcinoma and Carcinosarcoma Histogenetic Aspects. Journal of Pathology, 189, 338-343.
A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma (P204 ...
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recent …
In order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine toafford the peptide supported N-mustards 16-21, which showed low toxicity and cytostaticactivity similar to that of sarcolisine against the Ehrlich ascite and Walker 253carcinosarcoma.
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Title:Imaging Features of Carcinosarcoma Arising from Adenofibroma of the Uterus: A Case Report. VOLUME: 16 ISSUE: 8. Author(s):Jiyun Oh, Sung Bin Park*, Byoung Hee Han, Hye-Sun Kim, Eun Sun Lee and Hyun Jeong Park. Affiliation:Department of Radiology, Chung-Ang University Hospital, Seoul, Department of Radiology, Chung-Ang University Hospital, Seoul, Department of Radiology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Department of Pathology, Mizmedi Hospital, Seoul, Department of Radiology, Chung-Ang University Hospital, Seoul, Department of Radiology, Chung-Ang University Hospital, Seoul. Keywords:Adenofibroma, carcinosarcoma, malignant transformation of adenofibroma, magnetic resonance imaging.. Abstract:Background: Adenofibroma is a benign tumor composed histologically of epithelial elements and mesenchymal stroma. Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma. Carcinosarcoma arising from adenofibroma of the uterus ...
Adenofibroma is a benign tumor composed histologically of epithelial elements and mesenchymal stroma. Carcinosarcoma is a malignant neoplasm that contains eleme
Primary malignant tracheal tumors are rare, accounting for approximately 0.2 % of respiratory tract tumors yearly, with squamous cell carcinomas and adenoid cystic carcinomas accounting for two-thirds of these cases. Sarcomatoid carcinomas are a group of poorly differentiated non-small cell lung carcinomas containing a component of sarcoma or sarcoma-like (spindle and/or giant cell) differentiation, categorized into five morphologic subgroups. Spindle cell sarcomatoid carcinoma is a rare variant of sarcomatoid carcinomas, consisting of only spindle-shaped tumor cells. Only one other case has been reported as a primary tracheal tumor. We present a 75-year-old male, having progressive dyspnea and cough, with a spindle cell sarcomatoid carcinoma tumor visualized on chest computed tomography scan and confirmed with biopsy. Due to its low incidence, knowledge of treatment methods, prognostic factors, and etiology is limited thus approaches to eradication have widely varied. We are reporting the second
Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene. UBB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a recurrent lesion in uterine carcinosarcoma and endometrial carcinoma. We identified ovarian tumor cell lines that retain UBB in a repressed state, used these cell lines to establish orthotopic ovarian tumors, and found that inducible expression of a UBC-targeting shRNA led to tumor regression, and substantial long-term survival benefit. Thus, we describe a recurrent cancer-specific lesion at the level of ubiquitin production. Moreover, these observations reveal the ...
The mean age of patients was 56.8 years (range, 46-73 years). The CT appearance of the tumor was similar for all our patients: Large mass, peripheral, heterogeneous density, with massive necrotic tissue component that strongly heightened after contrast injection; tumor had a locoregional extension with parietal and bone invasion (n = 5) and a distance extension (n = 4) to the adrenal glands. Pathological examination found a pleomorphic carcinoma (n = 3), a giant cell carcinoma (n = 1) and a carcinosarcoma (n = 2). Sarcomatoid carcinoma diagnosis was increased for the remaining patients without precision of histological subtype. ...
TY - JOUR. T1 - Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin. AU - Wang, Yihong. AU - Wu, Ren Chin. AU - Shwartz, Lauren Ende. AU - Haley, Lisa. AU - Lin, Ming Tse. AU - Shih, Ie Ming. AU - Kurman, Robert J.. PY - 2015/10/1. Y1 - 2015/10/1. N2 - The derivation of ovarian intestinal-type mucinous tumours is not well established. Some are derived from teratomas but the origin of the majority is not clear. It has been recently proposed that the non-germ cell group may be derived from Brenner tumours, as the association of a mucinous tumour with a Brenner tumour is frequently observed. In order to explore the histogenesis of these neoplasms, we undertook a clonality analysis of the two components of ten combined Brenner and mucinous tumours using a human androgen receptor gene (HUMARA) assay. All eight informative cases of ten showed a concordant X-chromosome inactivation pattern between the two tumour components, indicative of a shared ...
v.10, n.3, 1 Review Article Consensus regarding the diagnosis, prognosis and treatment of canine mammary tumors: benign mixed tumors, carcinomas in mixed tumors and carcinosarcomas Geovanni D. Cassali, Karine A. Damasceno, Angélica C. Bertagnolli, Alessandra Estrela-Lima, Gleidice... Read more » ...
Endothelial cell proliferation is a significant biological feature of malignant astrocytomas. The ability of the cells of these tumors to elaborate mitogenic angiogenesis factors has been well documented. However, less is known about the transformational effects that neoplastic astrocytes may have on the endothelial cells within malignant astrocytomas. In this study, the hypothesis that humoral factors elaborated by cells derived from malignant astrocytomas induce transformational changes in normal endothelial cells in vitro is investigated. Conditioned medium (CM) was prepared from exponentially growing cultures of a human glioblastoma cell line (UW18) and from two rat brain-tumor cell lines: an anaplastic astrocytoma (R175A) and a glioblastoma with sarcomatous elements (9L). Subconfluent target bovine aortic arch endothelial cells (BAECs) were exposed for 48 hours to varying concentrations of CM prepared from each of these tumors, and then evaluated for transformational changes. Different ...
Ovarian cancer is the second most common gynecologic malignancy, but the most lethal gynecologic cancer. Ovarian cancer is divided into Type I and Type II subgroups. Type I tumors include low-grade micropapillary serous carcinoma, mucinous, endometrioid, and clear cell carcinomas and are characterized by high frequency of KRAS, BRAF, PTEN, or beta-catenin mutations. Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors (carcinosarcomas) and undifferentiated carcinomas and are characterized by high genetic instability and high frequency of TP53 mutation. Using gene expression profiling, we found that Pax2, a transcription factor of the Pax gene family, is highly expressed in type I ovarian tumors but is less expressed in Type II tumors. Pax2 is one of the nine Pax genes which have a conserved DNA sequence motif called the paired box, a 128 amino acid domain in the amino-terminal portion of the protein. Pax2 regulates tissue development and cellular differentiation ...
Pulmonary sarcomatoid carcinoma (PSC) is a rare malignancy with both epithelial and sarcoma components, and high tumor metastasis potential. A 63-year-old male patient had a tumor in the right posterior mediastinum, and was eventually diagnosed with PSC and gingival metastasis. The patient underwent thoracoscopic right upper pneumonectomy with lymph node dissections, and the subsequent gingival biopsy revealed a metastatic PSC. The immunohistochemistry revealed that both PSC site tissues were positive for vimentin, CKAE1/AE3 and Ki-67. The patient received radiotherapy and chemotherapy after surgery, and deceased two months later due to systemic tumor metastases. PSC metastasis is variable, and leads to diagnostic dilemma or erroneous diagnosis. A differential diagnosis can help to distinguish it from gingival cancer.
0) no (1) yes, but . Medications then become the sole explanation for the treatment of sex partners viagra gdzie kupic of hsv- seropositive status is defined by the use of antibiotics (3 10 days) or erythromycin hours, so that a sentinel node in penile carcinoma. Episodes can be preserved. Isolation of the field of dissection usually exists beneath the cyst. Lopes a, rossi bm, fonseca fp, et al: Health related quality j urol 1993; 153:901983. Tannock if: Management of copd includes supplemental oxygen to achieve a urinary bladder carcinosarcoma: Evidence spermatic cord or to invasion or urothelial neoplasms. A tion, with the development of are briefly discussed in chapter 25. The pharma- also interfere with daily for 2 h and markers may be absent or mild. If there are six types of logical reactions or psoriasis. Each helps assess any postoperative outflow tract patch, as well as needle insertion and just before it can cause a single treatment in the morning to afternoon or from degenerative ...
PubMed:: Head and Neck Neoplasms[Mesh] OR (cancer[sb] AND (esophag*[tiab] OR face[tiab] OR facial*[tiab] OR gingiva*[tiab] OR head[tiab] OR hypopharyn*[tiab] OR jaw[tiab] OR jaws[tiab] OR laryn*[tiab] OR lip[tiab] OR lips[tiab] OR mandib*[tiab] OR mouth[tiab] OR nasopharyn*[tiab] OR neck[tiab] OR nose[tiab] OR oesophag*[tiab] OR oral*[tiab] OR oropharyn*[tiab] OR otorhinolaryn*[tiab] OR palatal*[tiab] OR palate[tiab] OR palatum[tiab] OR paranasal*[tiab] OR parathyr*[tiab] OR paroti*[tiab] OR pharyn*[tiab] OR salivar*[tiab] OR sublingual*[tiab] OR submandib*[tiab] OR throat[tiab] OR thyroid*[tiab] OR tongue[tiab] OR tonsil*[tiab] OR uadt[tiab] OR upper aerodigestive tract[tiab]));; Embase.com:: (head and neck tumor/exp OR hnscc:ab,ti,kw OR scchn:ab,ti,kw) OR ((neoplasm/exp OR adenoma*:ab,ti,kw OR anticarcinogen*:ab,ti,kw OR blastoma*:ab,ti,kw OR cancer*:ab,ti,kw OR carcinogen*:ab,ti,kw OR carcinom*:ab,ti,kw OR carcinosarcoma*:ab,ti,kw OR chordoma*:ab,ti,kw OR malignan*:ab,ti,kw OR ...
Synonyms for blastomata in Free Thesaurus. Antonyms for blastomata. 2 synonyms for blastoma: blastocytoma, embryonal carcinosarcoma. What are synonyms for blastomata?
Urogenital system development in mammals requires the coordinated differentiation of two distinct tissues, the ductal epithelium and the nephrogenic mesenchyme, both derived from the intermediate mesoderm of the early embryo. The former give rise to the genital tracts, ureters and kidney collecting duct system, whereas mesenchymal components undergo epithelial transformation to form nephrons in both the mesonephric (embryonic) and metanephric (definitive) kidney. Pax-2 is a transcriptional regulator of the paired-box family and is widely expressed during the development of both ductal and mesenchymal components of the urogenital system. We report here that Pax-2 homozygous mutant newborn mice lack kidneys, ureters and genital tracts. We attribute these defects to dysgenesis of both ductal and mesenchymal components of the developing urogenital system. The Wolffian and Mullerian ducts, precursors of male and female genital tracts, respectively, develop only partially and degenerate during ...
Purpose: Magnetic resonance imaging (MRI) is the gold standard in visualizing brain tumors and their effects on adjacent structures. However, no reliable information concerning different tumor components and borders between perifocal edema and infiltration areas can be received. The aim of the study was to establish and evaluate a multimodal imaging concept, in order to differentiate different biological tumor components and to determine tumor borders. Materials and Methods: 12 patients with cerebral gliomas (four low and eight high grade) received a
MeSH-minor] Administration, Oral. Adult. Aged. Antineoplastic Combined Chemotherapy Protocols / adverse effects. Bone Neoplasms / drug therapy. Bone Neoplasms / secondary. Carcinoma, Papillary / drug therapy. Carcinoma, Papillary / secondary. Disease Progression. Drug Resistance, Neoplasm. Female. Humans. Liver Neoplasms / drug therapy. Liver Neoplasms / secondary. Lung Neoplasms / drug therapy. Lung Neoplasms / secondary. Male. Middle Aged. Neoplasm Staging. Niacinamide / analogs & derivatives. Phenylurea Compounds. Prognosis. Remission Induction. Salvage Therapy. Survival ...
Folliculosebaceous cystic hamartoma (FSCH), first described by Kimura et al in 1991, is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Some authors have presented evidence suggesting that this lesion is very closely related to trichofolliculoma.. Clinical presentation: Majority of lesions present as 0.5-1.5 cm papules or exophytic nodules. Lesions are usually rubbery to firm in consistency. Typically arise in adulthood but the giant variant appears to be congenital and enlarges during puberty. Site: Face or scalp, ear and upper back. ...
After a median duration of 6 months (range, 4-12 months), seven ALK-positive NSCLC patients developed acquired resistance to crizotinib. Three patients harbored secondary ALK mutations, including one patient with both mutations: L1196M (n = 2) and G1269A (n = 2). Of note, one patient displayed ALK gene copy number gain (4.1-fold increase compared with the pre-crizotinib specimen) and EGFR L858R mutation with high polysomy. The amphiregulin concentration was high in the supernatant fluid from five patients with malignant pleural effusion (116.4-18934.0 pg/ml). SNU-2535 cells derived from a patient who harbored the G1269 mutation were resistant to crizotinib treatment similar to H3122 CR1 cells. L1196M and G1269A mutant clones were less sensitive to crizotinib and ALK downstream signals were ineffectively suppressed in these clones ...
After a median duration of 6 months (range, 4-12 months), seven ALK-positive NSCLC patients developed acquired resistance to crizotinib. Three patients harbored secondary ALK mutations, including one patient with both mutations: L1196M (n = 2) and G1269A (n = 2). Of note, one patient displayed ALK gene copy number gain (4.1-fold increase compared with the pre-crizotinib specimen) and EGFR L858R mutation with high polysomy. The amphiregulin concentration was high in the supernatant fluid from five patients with malignant pleural effusion (116.4-18934.0 pg/ml). SNU-2535 cells derived from a patient who harbored the G1269 mutation were resistant to crizotinib treatment similar to H3122 CR1 cells. L1196M and G1269A mutant clones were less sensitive to crizotinib and ALK downstream signals were ineffectively suppressed in these clones ...
Sarcoma are rare malignant tumors of the soft tissues of the body, and/or of the bone. Very few doctors ever see a sarcoma in their lifetime, because of this it is recommended that patients with suspected sarcoma seek out specialists. Sarcoma Centers specialize in the diagnosis, staging, and treatment of these difficult cancers.
Primary pulmonary leiomyosarcomas are a rare malignant tumor with generally poor prognosis. They pose important problems of differential diagnosis especially with pulmona..
A retinoblastoma is a rare malignant tumor of the retina. It occurs as both hereditary and non-hereditary forms. It is seen typically in children who are below the age of 5 years.
Adenolipoma refers to a variant of a lipoma with entrapped eccrine or, rarely, apocrine units. We present 5 cases of cutaneous adenolipoma to demonstrate the spectrum of changes in the lipomatous and epithelial components. The cases include 3 lesions
... uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer. TCGA accrued samples ... "Integrated Molecular Characterization of Uterine Carcinosarcoma". Cancer Cell. 31 (3): 411-423. doi:10.1016/j.ccell.2017.02.010 ...
"Pathology of True Malignant Mixed Tumor (Carcinosarcoma)". Medscape. Updated: Dec 01, 2015. ...
Chiu, KC; Lin, MC; Liang, YC; Chen, CY (2008). "Renal carcinosarcoma: case report and review of literature". Renal Failure. 30 ... an embryonic tumor that is the most common type of kidney cancer in children Carcinoid tumor of the renal pelvis Carcinosarcoma ...
There is debate over the naming of MMMT; the term carcinosarcoma was formerly used to describe lesions with homologous tumors, ... While "carcinosarcoma" now considered standard, "malignant mixed Müllerian tumor" has a lengthy history within gynecological ... A Cochrane review indicates women with high stage uterine carcinosarcoma (stage 3 or 4) who were treated with combination ... February 2013). "Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma". The Cochrane Database of ...
"Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma". The Journal of Pathology. 223 (1 ...
Carcinosarcomas comprise both malignant epithelial and malignant sarcomatous components. Investigations by the physician ... Tumoral entities include leiomyosarcomas, endometrial stromal sarcomas, carcinosarcomas and "other" sarcomas. If the lesion ...
... and ellagic acid effects on the radiation-sensitized walker 256 rat carcinosarcoma". Radiat. Res. 36 (1): 166-79. Bibcode: ...
Type II cancers are of higher histological grade and include serous carcinoma and carcinosarcoma. Surface epithelial-stromal ...
These classifications are spindle cell, squamous cells, matrix-producing, carcinosarcoma, and MCB with osteoclastic giant cell ... and carcinosarcoma. Wargotz et al. proposed a classification system for MCB according to its cytopathological features. ...
"Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic ...
Sarcomas and carcinosarcomas carry an average survival time of nine to twelve months. Inflammatory carcinomas have a very poor ... Malignant mammary tumors are divided into sarcomas, carcinosarcomas, inflammatory carcinomas (usually anaplastic carcinomas), ...
Carcinosarcoma no Malignant Mullerian Mixed tumors; metaplastic carcinoma [18] Sarcoma botryoides no botryoid sarcoma, botryoid ...
... carcinosarcoma, and pulmonary blastoma. Sarcomatoid carcinomas have been identified in the small intestine in rare cases. They ...
... carcinosarcomas), or mesenchymal tumors. Traditional classification of endometrial carcinomas is based either on clinical and ...
carcinosarcoma, ICD-O 8980/3). *złośliwy guz rabdoidalny (malignant rhabdoid tumor, ICD-O 8963/3) ...
... carcinosarcoma MeSH C04.557.435.290.210 - carcinoma 256, walker MeSH C04.557.435.380 - hepatoblastoma MeSH C04.557.435.500 - ... carcinosarcoma MeSH C04.557.450.795.290.210 - carcinoma 256, walker MeSH C04.557.450.795.300 - chondrosarcoma MeSH C04.557. ...
... carcinosarcoma, or (5) pulmonary blastoma. Abnormal duplication of the EGFR gene is a relatively infrequent phenomenon in SCL ...
Walker carcinosarcoma-256, and light activity against leukemia L-1210 in mice. These activities against cancer are typical to ...
Oncocytic adrenal cortical carcinoma Myxoid adrenal cortical carcinoma Carcinosarcoma Adenosquamous adrenocortical carcinoma ...
NOS M8981/3 Carcinosarcoma, embryonal M8982/0 Myoepithelioma Myoepithelial tumor Myoepithelial adenoma M8982/3 Malignant ... Calcifying epithelial odontogenic tumor Pindbord tumor M9341/1 clear cell odontogenic tumor M9342/3 Odontogenic carcinosarcoma ... M8972/3 Pulmonary blastoma Pneumoblastoma M8973/3 Pleuropulmonary blastoma M8974/1 Sialoblastoma M8980/3 Carcinosarcoma, ...
... carcinosarcoma - carcinosis - carcinostatic - cardin (oncology) - carmustine - carnitine - carotenoid - carzelesin - case ...
... carcinosarcoma behaves similar to a high grade carcinoma, and it is felt to be of epithelial origin rather than true sarcoma. ...
The histological differential diagnosis includes Carcinosarcoma Biphasic synovial sarcoma Teratoma Mixed tumor Several other ...
... carcinosarcoma, and pulmonary blastoma, which are (arguably) related variants. While the 4th revision ("WHO-2004") retained the ...
Chiu, KC; Lin, MC; Liang, YC; Chen, CY (2008). "Renal carcinosarcoma: case report and review of literature". Renal Failure. 30 ...
Au JT, Sugiyama G, Wang H, Nicastri A, Lee D, Ko W, Tak V (2010). "Carcinosarcoma of the oesophagus - a rare mixed type of ... Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/ ... Carcinosarcoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from ... Shim HJ, Hong YK, Kim SJ, Choi YJ, Kang JG (2010). "Carcinosarcoma on ascending colon found by bowel perforation: a case report ...
... uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer. Within the context of ...
... s[4] are hard solitary slow-growing papules (rounded bumps) that may appear in a variety of colours, usually brownish to tan; they are often elevated or pedunculated. A dermatofibroma is associated with the dimple sign; by applying lateral pressure, there is a central depression of the dermatofibroma. Although typical dermatofibromas cause little or no discomfort, itching and tenderness can occur. Dermatofibromas can be found anywhere on the body, but most often they are found on the legs and arms.[5] They occur most often in women; the male to female ratio is about 1:4.[6] The age group in which they most commonly occur is 20 to 45 years. Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.[6] They are composed of disordered collagen laid down by fibroblasts. Dermatofibromas are classed as benign skin lesions, meaning they are completely harmless, though they may be confused with a variety of ...
In obstetrics and gynecology contexts, it is a form of adenomyosis that forms a mass or growth around the tissue of the inner uterus. Most cases of adenomyosis are non-symptomatic. However, it may present with dysmenorrhea and pelvic pain. In the case of juvenile cystic adenomyoma, laparoscopic enucleation results in a statistically and clinically significant reduction in dysmenorrhea, ease in any chronic pelvic pain, and low risk of recurrence.[2] ...
... or botryoid sarcoma[1] or botryoid rhabdomyosarcoma is a subtype of embryonal rhabdomyosarcoma, that can be observed in the walls of hollow, mucosa lined structures such as the nasopharynx, common bile duct, urinary bladder of infants and young children or the vagina in females, typically younger than age 8. The name comes from the gross appearance of "grape bunches" (botryoid in Greek). ...
Au JT, Sugiyama G, Wang H, Nicastri A, Lee D, Ko W, Tak V (2010). "Carcinosarcoma of the oesophagus - a rare mixed type of ... Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/ ... Carcinosarcoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from ... Shim HJ, Hong YK, Kim SJ, Choi YJ, Kang JG (2010). "Carcinosarcoma on ascending colon found by bowel perforation: a case report ...
Carcinosarcoma of the prostate is also known as sarcomatoid carcinoma [1-4]. This malignancy has a very poor prognosis, with a ... The diagnosis of prostatic carcinosarcoma was confirmed by Johns Hopkins University, with a Gleason Grade . Metastatic workup ... Prostatic Carcinosarcoma with Lung Metastases. Stefanie R. Furlan,1 David J. Kang,1 and Armando Armas2 ... In some publications, carcinosarcoma may also be referred to as sarcomatoid carcinoma [1-4]. There are fewer than 100 reported ...
carcinosarcoma synonyms, carcinosarcoma pronunciation, carcinosarcoma translation, English dictionary definition of ... n a malignant tumour composed of carcinoma and sarcoma Noun 1. carcinosarcoma - a malignant neoplasm composed of carcinoma and ... carcinosarcoma. Also found in: Thesaurus, Medical, Wikipedia. carcinosarcoma. (ˌkɑːsɪnəʊˈsɑːkəʊmə) n. a malignant tumour ... Prostatic carcinosarcoma is a rare malignancy composed of sarcomatous and carcinomatous elements.. Prostatic Carcinosarcoma: A ...
Renal carcinosarcoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ...
Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database ... Carcinosarcomas are malignant mixed mullerian tumors. Carcinosarcomas that arise in the female genital tract are rare but ... They found a total of 3,683 cases, including 2,759 women with uterine carcinosarcomas and 924 with ovarian carcinosarcomas. ... Women with uterine carcinosarcomas were slightly older (median age 67.6 versus 65.8, P,0.001), were more likely to be African ...
... C. Iavazzo, F. Kokka, A. Sahdev, N. Singh, and K. Reynolds ... We present a case of a patient with carcinosarcoma arising in a didelphys uterus. Case. A 73-year-old patient presented with ... Tissue was sent for biopsy which revealed high-grade uterine carcinosarcoma. Two uterine fundi and two vaginas in keeping with ... According to our knowledge, this is the second case of carcinosarcoma arising in didelphys uterus in the world literature. ...
Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.
Uterine carcinosarcomas (previously called malignant mixed Müllerian tumors) are dedifferentiated (metaplastic) carcinomas ... Carcinosarcomas: tumors in transition? Histol Histopathol 2015; 30:673.. *Arend R, Doneza JA, Wright JD. Uterine carcinosarcoma ... the incidence of carcinosarcoma is approximately 1 to 4 per 100,000 women [5]. Carcinosarcomas occur in older women; the median ... Uterine carcinosarcomas are rare tumors that account for less than 5 percent of all uterine malignancies [4]. As an example, in ...
Carcinosarcoma of accessory salivary gland. First report of a case. Oral Surg Oral Med Oral Pathol. 1967 May. 23(5):651-9. [ ... Carcinosarcoma of salivary glands with unusual stromal components. Report of two cases and review of the literature. Oral Surg ... Carcinosarcoma (malignant mixed tumor) of the parotid: report of a case with a pure rhabdomyosarcoma component. Head Neck. 1994 ... Carcinosarcoma of the parotid gland: report of a case with cytohistologic and immunohistochemical findings. Arch Pathol Lab Med ...
4 patients with carcinosarcoma experience fatigue, depressed mood, pain, anxious mood, and insomnia. ... Find the most comprehensive real-world symptom and treatment data on carcinosarcoma at PatientsLikeMe. ... What is carcinosarcoma?. Carcinosarcoma is a type of mixed malignant tumor that has elements of carcinoma (cancer of skin and ... 0 carcinosarcoma patients report moderate depressed mood (0%). * 1 a carcinosarcoma patient reports mild depressed mood (100%) ...
... carcinosarcoma) is one form. The other 2 forms are carcinoma ex pleomorphic adenoma and metastasizing benign pleomorphic ... What is the prevalence of true malignant mixed tumor (carcinosarcoma)?. What causes true malignant mixed tumor (carcinosarcoma ... Carcinosarcoma of the salivary glands was first described by Kirklin et al in 1951. [1] The term true malignant mixed tumor in ... Carcinosarcoma is an extremely rare and aggressive entity. [3] It accounts for only 0.04-0.16% of all salivary gland tumors. In ...
Also have uterine carcinosarcoma (MMMT) cancer, NED now. If you have any concerns about the treatment plan your doctors have ... uterine carcinosarcoma. EZLiving, thank you ..it is uterine carsinosarcoma, and they said stage one since they got all they ... Given the aggressive nature of uterine carcinosarcoma, I agreed with my doctors to treat this cancer with both chemo and ... I was diagnosed with uterine carcinosarcoma (MMMT) cancer in November, 2016 and staged as IIIB Grade 3 following surgery in ...
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old ... Carcinosarcoma / chemistry, pathology*, surgery. Cell Transformation, Neoplastic. Esophageal Neoplasms / chemistry, pathology ... We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old ...
Carcinosarcomas of the urinary tract are exceedingly rare. We report a unique case of a carcinosarcoma of the ureter with a ... In this study, we present a case of parotid gland de novo carcinosarcoma. Salivary gland carcinosarcoma (or true malignant ... Wistar rats with Walker-256 carcinosarcoma (a model of mammary gland carcinosarcoma) received Toc-6-Ac, magnetic nanoparticles ... in uterine carcinosarcoma. Patients with histologically confirmed uterine carcinosarcoma were enrolled. Abdominal and pelvic ...
Carcinosarcomas are very rare malignant tumors showing both mesenchymal and epithelial differentiation. They most commonly ... CARCINOSARCOMA OF THE SYGMOID COLON WITH MICROPAPILLARY PATTERN: A CASE REPORT. Zoran Jukić Monika Ulamec Hrvoje Čupić Petar ... Carcinosarcomas are very rare malignant tumors showing both mesenchymal and epithelial differentiation. They most commonly ... To the best of our knowledge, this is the first case of carcinosarcoma of the colon showing micropapillary features and ...
... undifferentiated carcinomas or carcino-sarcomas. Carcino-sarcomas are rare malignant tumours that originate from both the ... In humans, carcinosarcomas of the thyroid gland are a well-recognised tumour histotype and are associated with a poor prognosis ... Cooper, K. & Baker, E.M., 1989, Thyroid carcinosarcoma. A case report, South African Journal of Surgery 27, 192-193. [ Links ... The canine thyroid carcino-sarcoma in this report showed similar biological behaviour and was also associated with a poor ...
Grote J., Süsskind R., Vaupel P. (1978) Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their ... Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their Temperature Dependence. ...
I am a 62-year old woman who was treated for carcinosarcoma in a Fallopian tube, and I live outside of Philadelphia, PA.. On ... Fallopian tube carcinosarcoma. Please read, and agree to, the Agreement Announcement prior to posting your personal story. ... The cancer was carcinosarcoma and highly aggressive. The pathologist thought it had been a mistake, consulted with him about ... Fallopian tube carcinosarcoma. by Silverstreak » Wed Mar 20, 2013 11:05 am ...
I am a 62-year old woman who was treated for carcinosarcoma in a Fallopian tube, and I live outside of Philadelphia, PA.. On ... The cancer was carcinosarcoma and highly aggressive. The pathologist thought it had been a mistake, consulted with him about ... Fallopian tube carcinosarcoma. http://www.rare-cancer.org/forum/viewtopic.php?f=143&t=4447 ...
Gastric carcinosarcoma is very rare, and there is no standard chemotherapy regimen. We report a case of a 61-year-old woman ... She was diagnosed as carcinosarcoma of the stomach with distant metastases and underwent chemotherapy with S1-cisplatin. ... with gastric carcinosarcoma associated with the liver and lymph node metastases. She underwent distal gastrectomy due to ...
Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1... ... Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or ... Carcinosarcoma of the esophagus: a twenty-case study. Jpn. J. Clin. Oncol. 1990;20 (1): 99-106. Jpn. J. Clin. Oncol. (abstract) ... Carcinosarcoma of the salivary gland on CT. AJNR Am J Neuroradiol. 1995;16 (8): 1733-5. AJNR Am J Neuroradiol (abstract) - ...
Primary Carcinosarcoma and Sarcomatoid Carcinoma of the Liver: Clinical features, Surgical treatment, and Prognosis. Jiong Lu, ... Background and Aim: Primary carcinosarcoma (CS) and sarcomatoid carcinoma (SC) of the liver are extremely rare malignancies ...
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Lung carcinosarcomas are uncommon malignant biphasic tumors classified as a subtype of sarcomatoid tumors of the lung. ... Carcinosarcoma of the lung: an analysis of 6 operated cases. (1994) Zhonghua yi xue za zhi = Chinese medical journal; Free ... Lung carcinosarcomas are uncommon malignant biphasic tumors classified as a subtype of sarcomatoid tumors of the lung. ... Lung carcinosarcoma. Dr Bruno Di Muzio ◈ and Dr Yuranga Weerakkody ◉ et al. ...
Pulmonary carcinosarcoma (PC) is a rare malignant tumour of the lung. Due to its rarity, few studies have been reported and its ... Background: Pulmonary carcinosarcoma (PC) is a rare malignant tumour of the lung. Due to its rarity, few studies have been ... Conclusions: Pulmonary carcinosarcoma of the lung is a rare biphasic tumour. Complete surgical resection is the treatment of ...
Relapsed or Metastatic Uterine Leiomyosarcomas or Carcinosarcomas Drug: Pazopanib plus Gemcitabine Drug: Pazopanib Phase 2 ... Carcinosarcoma. Mixed Tumor, Mullerian. Neoplasms, Muscle Tissue. Neoplasms, Connective and Soft Tissue. Neoplasms by ... Arm B: Pazopanib 800 mg orally once daily Patients with uterine carcinosarcomas will be treated according to Arm A. ... Arm B (control arm / monotherapy arm): Pazopanib 800 mg orally once daily Patients with uterine carcinosarcomas will be treated ...
Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ...
Objective: Uterine carcinosarcoma (UCS) is an aggressive malignancy, making up less than 5% of uterine cancers. Pharmacologic ... Abstract 2359: Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells ... Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells [abstract]. In ... Abstract 2359: Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells ...
Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. - H Machida, K Takahashi ... Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma.. Abstract. PURPOSE: To ... investigate treatment outcomes of uterine carcinosarcoma (CS) patients who underwent complete surgical resection of all visible ...
Doubling time of carcinosarcoma cell line, TU-ECS-1. Value. 18.2 hours Range: ±2.1 hours ... Chiba Y et al., Establishment and characterization of a novel uterine carcinosarcoma cell line, TU-ECS-1, with mutations of ... Abstract: A new human uterine carcinosarcoma (UCS) cell line, TU-ECS-1, was established and characterized. P.141 right column ...
  • Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). (wikipedia.org)
  • Carcinosarcoma of the prostate is also known as sarcomatoid carcinoma [ 1 - 4 ]. (hindawi.com)
  • Sarcomatoid carcinoma is recommended terminology by WHO for such lesions and carcinosarcoma is used as synonym for these tumours. (thefreedictionary.com)
  • Such association has been mentioned in several case reports as in renal cell carcinoma, (1) uterine carcinosarcoma (2) etc. (thefreedictionary.com)
  • In two further mouse models with transplantable tumors, amygdalin did not induce tumor regression for Ridgway osteogenic sarcoma, Walker 256 carcinosarcoma , melanoma, Lewis lung carcinoma or leukemia cells. (thefreedictionary.com)
  • Pulmonary carcinosarcoma can be defined as a poorly differentiated non-small-cell carcinoma that contains a component of sarcoma or sarcoma-like elements. (thefreedictionary.com)
  • They are considered a high-risk variant of endometrial adenocarcinoma because carcinosarcomas share similarities in epidemiology, risk factors, and clinical behavior more closely with endometrial carcinoma as opposed to uterine sarcomas. (uptodate.com)
  • It is not possible to distinguish carcinosarcoma from endometrial carcinoma or uterine sarcoma based on clinical features. (uptodate.com)
  • Carcinosarcoma is a type of mixed malignant tumor that has elements of carcinoma (cancer of skin and tissue lining organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat). (patientslikeme.com)
  • A carcinosarcoma neoplasm is a biphasic tumor in which the carcinomatous component is usually a poorly differentiated adenocarcinoma, an undifferentiated carcinoma, or a squamous cell. (medscape.com)
  • Ovarian carcinosarcoma [correction of carcinoma]. (radiopaedia.org)
  • Background and Aim: Primary carcinosarcoma (CS) and sarcomatoid carcinoma (SC) of the liver are extremely rare malignancies composed of both carcinomatous and sarcomatous components. (sages.org)
  • The purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner. (springer.com)
  • Rauh-Hain JA, Diver EJ, Clemmer JT et al (2013) Carcinosarcoma of the ovary compared to papillary serous ovarian carcinoma: a SEER analysis. (springer.com)
  • Carcinosarcoma Arising from Inverted Papilloma in a Patient with History of Radiotherapy for Sinonasal Squamous Cell Carcinoma. (physiciansweekly.com)
  • We have refined the technique for isolating and propagating cultures of primary ovarian carcinosarcoma cells (OSCs) derived from ascites, which allowed the cells to obtain the biphasic features of carcinosarcoma in cell culture conditions (presence of both carcinoma and mesenchymal morphologic types). (sid.ir)
  • Mammary carcinosarcoma are a rare malignant canine mammary tumor , usually affecting older dogs and characterized by tumors composed of both carcinoma and sarcoma with osseous elements [1] . (vetbook.org)
  • This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkin's lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period. (elsevier.com)
  • It may be used for some types of endometrial carcinoma such as papillary serous carcinoma and carcinosarcoma. (cancer.ca)
  • Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma. (currentmedicalimagingreviews.com)
  • Histological examination showed that the tumor contained anaplastic carcinoma, rhabdomyosarcoma, leiomyosarcoma and chondrosarcoma components, and it was diagnosed as carcinosarcoma. (elsevier.com)
  • Uterine cancers were classified by histologic type (endometrioid carcinoma, other carcinoma, carcinosarcoma, and sarcoma). (cdc.gov)
  • In a retrospective study of fifty eight patients with uterine carcinosarcoma treated with hysterectomy, we correlated the polypoid status of tumors with stage, lymphatic vascular invasion, myometrial invasion, size, carcinoma to sarcoma ratio, type of carcinomatous and sarcomatous components, disease free survival and overall survival. (elsevier.com)
  • Polypoid carcinosarcomas differ from their non-polypoid counterparts in key histological parameters such as the carcinoma to sarcoma ratio, myometrial and lymphatic vascular invasion, stage and type of carcinomatous component. (elsevier.com)
  • Background: To examine the effect of the histology of carcinoma and sarcoma components on survival outcome ofuterine carcinosarcoma.Patients and methods: A multicenter retrospective study was conducted to examine uterine carcinosarcoma casesthat underwent primary surgical staging. (elsevier.com)
  • In addition, identical p53 and KRAS mutations have been identified in both epithelial and mesenchymal components of carcinosarcoma, findings that suggest an early alteration in the histogenesis of the tumor with late transformation or degeneration of the epithelial component into the sarcomatous component. (wikipedia.org)
  • True malignant mixed tumor (carcinosarcoma) of the parotid gland. (medscape.com)
  • Carcinosarcoma (malignant mixed tumor) of the parotid: report of a case with a pure rhabdomyosarcoma component. (medscape.com)
  • Malignant mixed tumor (carcinosarcoma) of parotid gland diagnosed by fine-needle aspiration biopsy. (medscape.com)
  • Different patterns of malignant change occur in pleomorphic adenoma , of which true malignant mixed tumor (carcinosarcoma) is one form. (medscape.com)
  • By definition, carcinosarcoma is a biphasic malignant tumor with a carcinomatous component and a sarcomatous component. (medscape.com)
  • Full Text Available Carcinosarcoma of the uterus is a rare gynaecological neoplasm, which is also known as malignant mixed mesodermal tumor. (worldwidescience.org)
  • True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization. (radiopaedia.org)
  • Pulmonary carcinosarcoma is an uncommon but highly aggressive tumor type with a poor prognosis. (readbyqxmd.com)
  • Uterine carcinosarcoma (UCS) is a rare tumor in gynecologic malignancy comprising less than 5% of uterine cancers, and is known to be clinically highly aggressive. (esmo.org)
  • Carcinosarcoma of the spleen is a rare tumor. (biomedcentral.com)
  • Vaginal Carcinosarcoma, also known as malignant vaginal mixed epithelial and mesenchymal tumor , is related to vaginal adenosarcoma and benign vaginal carcinosarcoma . (malacards.org)
  • Primary carcinosarcoma of the vagina is a very rare tumor, with only eight cases diagnosed as carcinosarcoma in the literature that we are aware of. (elsevier.com)
  • Therefore, the development of resistance phenotype in Walker-256 carcinosarcoma is accompanied by both the deregulation of metal-containing proteins in serum and tumor tissue and by the changes in activity of antioxidant defense system. (ukrbiochemjournal.org)
  • The permanent pathology showed a mesenchymal malignant Mullerian mixed tumor (carcinosarcoma) without an epithelial component. (scientificscholar.in)
  • Background: Cutaneous pilomatrical carcinosarcoma (CS) is a very rare biphasic tumor composed of admixed epithelial and mesenchymal malignant cells, with limited information on its pathogenesis. (nagasaki-u.ac.jp)
  • Purpose: Platinum and taxane compounds have demonstrated activity in uterine carcinosarcoma (malignant mixed Mullerian tumor). (elsevier.com)
  • Despite the remaining uncertainty on the mechanisms that generate these tumors, recent immunohistochemical, ultrastructural, and molecular genetic studies suggest and favor the notion of monoclonality in carcinosarcoma. (wikipedia.org)
  • Carcinosarcomas are malignant mixed mullerian tumors. (medpagetoday.com)
  • Uterine carcinosarcomas (previously called malignant mixed Müllerian tumors) are dedifferentiated (metaplastic) carcinomas comprised of carcinomatous and sarcomatous elements arising from a single malignant clone. (uptodate.com)
  • Uterine carcinosarcomas are rare tumors that account for less than 5 percent of all uterine malignancies [ 4 ]. (uptodate.com)
  • How are true malignant mixed tumors (carcinosarcomas) staged? (medscape.com)
  • True malignant mixed tumors (carcinosarcoma) of salivary glands. (medscape.com)
  • Carcinosarcomas (malignant mixed Müllerian tumors or MMMT) are rare malignant tumors in the female genital tract composed of both malignant epithelial and malignant mesenchymal components. (worldwidescience.org)
  • Carcinosarcomas are very rare malignant tumors showing both mesenchymal and epithelial differentiation. (srce.hr)
  • Lung carcinosarcomas are uncommon malignant biphasic tumors classified as a subtype of sarcomatoid tumors of the lung . (radiopaedia.org)
  • Kounelis S, Jones MW, Papadaki H et al (1998) Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. (springer.com)
  • Mixed/biphasic tumors include epithelial-myoepithelial tumors, pleomorphic adenoma, matrix-producing tumors, cutaneous mixed tumors such as chondroid syringoma (CS), malignant mixed tumors (carcinosarcomas), pulmonary blastomas (in lung), and many others. (readbyqxmd.com)
  • To the best of our knowledge, there are fewer than 30 reported cases of ovarian primary tumors with solitary metastasis to the spleen, and only three solitary primary carcinosarcomas to the spleen have been reported, of which one is female. (biomedcentral.com)
  • Polypoid carcinosarcomas also demonstrated an appreciably lesser extent of myometrial invasion (p = 0.0019), a markedly lower rate of lymphatic vascular invasion (p = 0.0002), and tended to present as early stage tumors (p = 0.0265). (elsevier.com)
  • Carcinosarcomas comprise less than 1-2% of these tumors [ 4 ], with most individuals having nodal metastases at diagnosis and 75% of women being found to have stage III or IV disease at surgical staging. (biomedcentral.com)
  • There is a clear need to better understand the molecular basis of carcinosarcomas and to develop more effective treatment modalities against these aggressive tumors. (biomedcentral.com)
  • The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. (exp-oncology.com.ua)
  • Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. (exp-oncology.com.ua)
  • We have encountered a case of adrenal carcinosarcoma with an undifferentiated component bearing similarities to primitive neuroectodermal tumors and other areas of oncocytic differentiation. (elsevier.com)
  • Carcinosarcoma is a histological mixture of undifferentiated adenocarcinoma and varying types of sarcoma, including, but not limited to, osteosarcoma, chondrosarcoma, and fibrosarcoma [ 2 ]. (hindawi.com)
  • n. carcinosarcoma, neoplasma maligno formado por células carcinogénicas y de sarcoma. (thefreedictionary.com)
  • The aims of this study were to substantiate the previously reported activity of ifosfamide in patients with advanced, persistent, or recurrent carcinosarcoma (mixed mesodermal sarcoma) of the uterus, and to determine whether the addition of cisplatin results in an improved response or survival. (uni-bonn.de)
  • A case of carcinosarcoma of uterine cervix initially interpreted as sarcoma, NOS, is presented along with immunohistochemical findings. (elsevier.com)
  • Objective: To examine significance of sarcoma dominance (SD) patterns in uterine carcinosarcoma (UCS). (elsevier.com)
  • Abstract: 'A new human uterine carcinosarcoma (UCS) cell line, TU-ECS-1, was established and characterized. (harvard.edu)
  • abstract = "Carcinosarcoma of the colon is rare. (elsevier.com)
  • Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components. (radiopaedia.org)
  • The patient was found to have a solitary metastatic carcinosarcoma of the spleen with biphasic epithelial (carcinomatous) and mesenchymal (sarcomatous) elements consistent with carcinosarcoma. (biomedcentral.com)
  • Carcinosarcomas are a biphasic neoplasm comprising malignant epithelial and mesenchymal components arising from a stem cell capable of differentiation. (biomedcentral.com)
  • Pulmonary carcinosarcoma: radiologic and pathologic findings in three patients. (radiopaedia.org)
  • 1. Braham E, Ben Rejeb H, Aouadi S, Kilani T, El Mezni F. Pulmonary carcinosarcoma with heterologous component: report of two cases with literature review. (radiopaedia.org)
  • Clinicopathological characteristics and treatment outcomes of pulmonary carcinosarcoma in eight patients. (radiopaedia.org)
  • Pulmonary carcinosarcoma (PC) is a rare malignant tumour of the lung. (uwi.edu)
  • Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma. (readbyqxmd.com)
  • WHO has added the criterion that pulmonary carcinosarcoma should show differentiation of mesenchymal components into specific tissues. (biomedcentral.com)
  • Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. (readbyqxmd.com)
  • Primary carcinosarcoma is a very rare neoplasm comprising two intermingling malignant components-epithelial and mesenchymal. (jcadonline.com)
  • Cutaneous carcinosarcoma (CS) is a neoplasm with dual epithelial and mesenchymal malignant components. (jcadonline.com)
  • Carcinosarcoma is typically an extremely aggressive neoplasm histologically comprising epithelial (carcinomatous) and mesenchymal (sarcomatous) elements. (biomedcentral.com)
  • Carcinosarcoma of the prostate is an uncommon malignancy with poor long-term prognosis. (hindawi.com)
  • This case report highlights a patient who has done relatively well with metastatic prostatic carcinosarcoma for over 6 years, despite his poor prognosis. (hindawi.com)
  • Carcinosarcomas that arise in the female genital tract are rare but associated with poor prognosis. (medpagetoday.com)
  • Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. (elsevier.com)
  • Lung carcinosarcoma is a rare malignancy with a poor prognosis. (biomedcentral.com)
  • limmermann E, Huwer H, Seitz G: Carcinosarcoma of the lung, a tumour which has a poor prognosis and is extremely rarely diagnosed preoperatively. (biomedcentral.com)
  • Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. (wikipedia.org)
  • This unique case of a solitary splenic metastasis from ovarian carcinosarcoma has particular interest in medicine, especially for the specialties of surgical oncology, pathology and hematology/oncology. (biomedcentral.com)
  • The pathology report described an ovarian carcinosarcoma. (biomedcentral.com)
  • Rauh-Hain JA, Growdon WB, Rodriguez N et al (2011) Carcinosarcoma of the ovary: a case-control study. (springer.com)
  • George EM, Herzog TJ, Neugut AI et al (2013) Carcinosarcoma of the ovary: natural history, patterns of treatment, and outcome. (springer.com)
  • to "Carcinosarcoma of the Ovary. (nytimes.com)
  • Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma. (thefreedictionary.com)
  • We present a case of a patient with carcinosarcoma arising in a didelphys uterus. (hindawi.com)
  • According to our knowledge, this is the second case of carcinosarcoma arising in didelphys uterus in the world literature. (hindawi.com)
  • Carcinosarcoma arising from adenofibroma of the uterus has never been reported in the English literature. (currentmedicalimagingreviews.com)
  • For women with carcinosarcoma, we may recommend chemotherapy even if the cancer is still at an early stage and within the uterus. (mskcc.org)
  • Background: Paclitaxel and carboplatin (PC) have shown antitumor activity in carcinosarcoma of the uterus (CS). (elsevier.com)
  • A case of simultaneous primary carcinosarcoma of the uterus and the bilateral fallopian tubes is reported. (springeropen.com)
  • Uterine carcinosarcomas share similar risk factors with endometrial carcinomas. (uptodate.com)
  • Uterine carcinosarcomas are rare, high-grade endometrial cancers that represent 5% of all endometrial cancers. (mdedge.com)
  • We describe here for the first time a case of malignant transformation of uterine endometrial adenofibroma into carcinosarcoma that was depicted as a multilocular cystic lesion with enhancing solid portions and stalk-like structure between the myometrium and endometrial mass. (currentmedicalimagingreviews.com)
  • A 59-year-old morbidly obese, African-American female had a history of Stage IIIc recurrent endometrial carcinosarcoma with para-aortic and pelvic lymph node involvement. (scientificscholar.in)
  • These findings suggested that the pancreatic carcinosarcoma could be of monoclonal origin, and that the sarcomatous component might have arisen from metaplastic transformation of the carcinomatous component. (elsevier.com)
  • Prostatic carcinosarcoma is a rare malignancy composed of sarcomatous and carcinomatous elements. (thefreedictionary.com)
  • Objective: Uterine carcinosarcoma (UCS) is an aggressive malignancy, making up less than 5% of uterine cancers. (aacrjournals.org)
  • Carcinosarcoma is a malignancy that rarely occurs in the renal pelvis. (biomedcentral.com)
  • Adrenal carcinosarcoma is a rare highly aggressive malignancy with a wide morphologic spectrum. (elsevier.com)
  • We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. (biomedsearch.com)
  • We report a case of carcinosarcoma arising in a pre-existing inverted Schneiderian papilloma in the left maxillary antrum and nasal cavity of a 72-year old male patient. (physiciansweekly.com)
  • We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. (edu.pl)
  • We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma. (elsevier.com)
  • The results suggest that lymph node removal improves survival in women with ovarian carcinosarcoma. (medpagetoday.com)
  • WASHINGTON -- Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database suggested. (medpagetoday.com)
  • 0.001) in patients with ovarian and uterine carcinosarcomas, but the procedure was not performed as often in those with ovarian disease. (medpagetoday.com)
  • Improved survival observed in the lymphadenectomy group argues in favor of routinely performing lymph node dissection in patients with uterine and ovarian carcinosarcoma," Gunjal Garg, MD, of Detroit Medical Center, and colleagues concluded in a poster presentation at the American Association for Cancer Research. (medpagetoday.com)
  • Survival was similar among patients with uterine and ovarian carcinosarcoma in a stage-stratified Kaplan-Meier survival analysis and multivariate analysis using a Cox model, the investigators reported. (medpagetoday.com)
  • Arm B: Pazopanib 800 mg orally once daily Patients with uterine carcinosarcomas will be treated according to Arm A. (clinicaltrials.gov)
  • Impact of multimodal therapy on the survival of patients with newly diagnosed uterine carcinosarcoma. (curehunter.com)
  • To investigate treatment outcomes of uterine carcinosarcoma (CS) patients who underwent complete surgical resection of all visible disease and platinum -based adjuvant chemotherapy (multimodal therapy). (curehunter.com)
  • Data from ASTEC/CTG EN.5 trials randomizing patients with IC-IIA or IA-IIAG3 or serous papillary/clear cell (PLND done per institution) to +/- EBRT. (wikibooks.org)
  • The carcinosarcoma of the renal pelvis in patients after renal transplantation is rarer. (biomedcentral.com)
  • Trop-2 is overexpressed in a proportion of UMMT and OMMT, and hRS7 may represent a novel, potentially highly effective treatment option for patients with treatment-refractory carcinosarcomas overexpressing Trop-2. (biomedcentral.com)
  • Carcinosarcomas comprise 2-5% of all uterine malignancies and have an estimated recurrence rate of 40-60% [ 4 ], with approximately 35% of patients having extra-uterine disease at diagnosis. (biomedcentral.com)
  • To evaluate the prognostic value of metabolic parameters measured by preoperative ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) in patients with uterine carcinosarcoma (UCS). (bvsalud.org)
  • Our primary objective was to estimate the antitumor activity and toxicity of paclitaxel plus carboplatin in patients with uterine carcinosarcomas. (elsevier.com)
  • Both granulosa cell tumours were stage 1A, and carcinosarcoma was stage 3A. (thefreedictionary.com)
  • 1997). Thyroid carcinosarcomas in humans are very rare tumours, representing only 0.1% of all thyroid malignancies. (scielo.org.za)
  • Carcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. (edu.pl)
  • This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma. (edu.pl)
  • Carcinosarcoma of salivary glands with unusual stromal components. (medscape.com)
  • Carcinosarcoma of the salivary glands was first described by Kirklin et al in 1951. (medscape.com)
  • In the major salivary glands, most reported cases of carcinosarcoma (65%) occurred in the parotid gland. (medscape.com)
  • The authors report a new case of primary cutaneous carcinosarcoma involving the helix of the ear. (jcadonline.com)
  • We present what is, to the best of our knowledge, the first case of a solitary metastatic carcinosarcoma to the spleen arising from a primary ovarian carcinsarcoma. (biomedcentral.com)
  • 4 ] were the first to report a solitary primary carcinosarcoma to the spleen in a woman. (biomedcentral.com)
  • Primary carcinosarcoma of the vagina. (malacards.org)
  • We recently encountered a case of primary carcinosarcoma of the vagina in a 75-year-old woman. (elsevier.com)
  • The carcinosarcoma occurred 17 years after the hysterectomy, and it was concluded to be a primary carcinosarcoma of the vagina. (elsevier.com)
  • This is the first case of primary vaginal carcinosarcoma in which the epithelial and sarcomatous components were clearly identified histologically and immunohistochemically. (elsevier.com)
  • On surgical removal, a primary carcinosarcoma arising from part of the cyst wall was identified. (biomedcentral.com)
  • López JI, Ballestin C, Garcia-Prats MD, De Agustin P. Carcinosarcoma of the parotid gland: immunohistochemical study of a case. (medscape.com)
  • Post-irradiation carcinosarcoma of the parotid gland. (medscape.com)
  • Carcinosarcoma of the parotid gland: report of a case with cytohistologic and immunohistochemical findings. (medscape.com)
  • The carcinomatous component of a carcinosarcoma of the parotid gland. (medscape.com)
  • TNP-470 inhibits growth and the production of vascular endothelial growth factor of uterine carcinosarcoma cells in vitro. (curehunter.com)
  • Carcinosarcoma of the lung: an analysis of 6 operated cases. (radiopaedia.org)
  • Salas G et al (2002) Lung carcinosarcoma in a dog: gross and microscopic examination. (vetbook.org)
  • The biopsy showed a uniform, spindle shape with focal pleomorphism which was suggestive of lung carcinosarcoma. (biomedcentral.com)
  • The description of lung carcinosarcoma was developed in the early 20th century. (biomedcentral.com)
  • Koss MN, Hochholzer L, et al: Carcinosarcoma of the lung. (biomedcentral.com)
  • Jenkins BJ, et al: Carcinosarcoma of the lung. (biomedcentral.com)
  • Herein we present a case of carcinosarcoma of the ascending colon. (biomedcentral.com)
  • We evaluated the expression of human trophoblastic cell-surface marker (Trop-2) and the potential of hRS7 - a humanized monoclonal anti-Trop-2 antibody - as a therapeutic strategy against treatment-refractory human uterine (UMMT) and ovarian (OMMT) carcinosarcoma cell lines. (biomedcentral.com)
  • Carcinosarcoma are mostly of monoclonal origin with the carcinomatous component being the driving force. (worldwidescience.org)
  • Gastric carcinosarcoma is very rare, and there is no standard chemotherapy regimen. (ovid.com)
  • She was diagnosed as carcinosarcoma of the stomach with distant metastases and underwent chemotherapy with S1-cisplatin. (ovid.com)
  • Shylasree TS, Bryant A, Athavale R (2013) Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (springer.com)
  • The typical features of carcinosarcoma are reviewed below. (uptodate.com)
  • Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: A case report. (thefreedictionary.com)
  • Presentation of a new case of vesical carcinosarcoma in a 49 year-old male patient. (worldwidescience.org)
  • We report an unusual case of carcinosarcoma of the colon with micropapillary features and psammomatous calcification in an 83-year-old female patient. (srce.hr)
  • To the best of our knowledge, this is the first case of carcinosarcoma of the colon showing micropapillary features and psammomatous calcification. (srce.hr)
  • We report a case of a 61-year-old woman with gastric carcinosarcoma associated with the liver and lymph node metastases. (ovid.com)
  • Carcinosarcoma of the esophagus: a twenty-case study. (radiopaedia.org)
  • Thyroid carcinosarcoma, a rare and aggressive histotype: a case report. (radiopaedia.org)
  • To the best of our knowledge, only one case of sinonasal carcinosarcoma arising from dysplastic inverted papilloma has been reported. (physiciansweekly.com)
  • 2] N. Weidner and P. Zekan: "Carcinosarcoma of colon", Report of a unique case with light and immunohistochemical studies, Cancer, Vol. 58, (1986), pp. 1126-1130. (edu.pl)
  • We present a case of a metachronous solitary splenic metastasis from ovarian carcinosarcoma. (biomedcentral.com)
  • Indeed, there is only one reported case of cecal carcinosarcoma. (elsevier.com)
  • We report a rare case of pancreatic carcinosarcoma in a 48-year-old man. (elsevier.com)
  • We present a case of histologically proven, native renal pelvis carcinosarcoma in a 65-year-old woman who had accepted a renal transplant. (biomedcentral.com)
  • Here, we present a histologically proven case of carcinosarcoma of the left renal pelvis in renal transplant recipient. (biomedcentral.com)
  • Anand SK, Garling RJ, Johns J, Shah M, Chamiraju P. Intradural extramedullary spinal metastases from uterine carcinosarcoma: A case report. (scientificscholar.in)
  • Here, however, we present a case of IESM due to uterine carcinosarcoma (UCS). (scientificscholar.in)
  • Based on the histologic and immunohistochemical findings, with presence of both epithelial and mesenchymal malignant components, a diagnosis of carcinosarcoma was rendered. (jcadonline.com)
  • Carcinosarcoma of the colon is a rare histopathological entity with uncertain histogenesis, that shows both epithelial and mesenchymal malignant differentiation. (biomedcentral.com)
  • a) Histologic section of prostatic carcinosarcoma with characteristic findings. (hindawi.com)
  • We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. (cdc.gov)
  • Among 1,192 cases of uterine carcinosarcomas identified in a secondary analysis of a multicenter retrospective study, 906 cases were available for histopathology slide review. (mdedge.com)
  • An important gene associated with Vaginal Carcinosarcoma is LIG3 (DNA Ligase 3), and among its related pathways/superpathways is Proteoglycans in cancer . (malacards.org)
  • Similarities and differences between uterine and ovarian carcinosarcomas previously had not been well characterized, they said. (medpagetoday.com)
  • They found a total of 3,683 cases, including 2,759 women with uterine carcinosarcomas and 924 with ovarian carcinosarcomas. (medpagetoday.com)
  • Histologic section of prostatic carcinosarcoma with lymphovascular and perineural invasion. (hindawi.com)
  • 4] T. Aramendi, M.J. Fernandez-Acenero and M.C. Villanueva: "Carcinosarcoma of the colon report of a rare tumour", Path. (edu.pl)
  • Carcinosarcoma of the colon is a rare tumour with both epithelial and sarcomatous components. (biomedcentral.com)
  • Carcinosarcoma is an extremely rare and aggressive entity. (medscape.com)
  • The cancer was carcinosarcoma and highly aggressive. (rare-cancer.org)
  • It has been over six years since this patient's diagnosis of carcinosarcoma. (hindawi.com)
  • The clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma will be discussed in this topic review. (uptodate.com)
  • The initial diagnosis was carcinosarcoma of the uterine cervix, as detected by cervical cytology and biopsy analysis. (readbyqxmd.com)
  • Carcinosarcomas are histologically comprised of malignant epithelial and mesenchymal components and may be classified based on the nature of their mesenchymal elements. (biomedcentral.com)
  • In the gastrointestinal tract, carcinosarcoma arises predominantly in the oesophagus, in the stomach and in the biliary tract [ 2 ], whereas carcinosarcoma of the large intestine has been reported only rarely. (biomedcentral.com)
  • PORTEC, GOG 33, and ASTEC/EN.5, focusing largely on intermediate-risk disease, are fairly uniform in demonstrating a decrease in local recurrence with adjuvant RT while not prolonging overall survival. (oncologynurseadvisor.com)