Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Carcinoma 256, Walker: A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)Uterine Neoplasms: Tumors or cancer of the UTERUS.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Mixed Tumor, Mullerian: A tumor, basically a carcinoma with a single sarcoma such as leiomyosarcoma or angiosarcoma or multiple sarcomas of uterine origin. The role of estrogen has been postulated as a possible etiological factor in this tumor. (Holland et al., Cancer Medicine, 3d ed, p1703)Dermoid Cyst: A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)Pyonephrosis: Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalPhonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)Mixed Tumor, Malignant: A malignant tumor composed of more than one type of neoplastic tissue. (Dorland, 27th ed)Lymph Node Excision: Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.WashingtonHistiocytoma, Benign Fibrous: A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Histiocytoma, Malignant Fibrous: The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.Fasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Xanthophylls: Oxygenated forms of carotenoids. They are usually derived from alpha and beta carotene.Myoepithelioma: A usually benign tumor made up predominantly of myoepithelial cells.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Adenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Solitary Pulmonary Nodule: A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Multiple Pulmonary Nodules: A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Kinesics: Systematic study of the body and the use of its static and dynamic position as a means of communication.Hysterectomy: Excision of the uterus.Fallopian Tubes: A pair of highly specialized muscular canals extending from the UTERUS to its corresponding OVARY. They provide the means for OVUM collection, and the site for the final maturation of gametes and FERTILIZATION. The fallopian tube consists of an interstitium, an isthmus, an ampulla, an infundibulum, and fimbriae. Its wall consists of three histologic layers: serous, muscular, and an internal mucosal layer lined with both ciliated and secretory cells.Self-Help Groups: Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.Rare Diseases: A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.Hysterectomy, Vaginal: Removal of the uterus through the vagina.Intergenerational Relations: The interactions between individuals of different generations. These interactions include communication, caring, accountability, loyalty, and even conflict between related or non-related individuals.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Radiology: A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.Lung Neoplasms: Tumors or cancer of the LUNG.Sarcoma, Synovial: A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Ataxia Telangiectasia Mutated Proteins: A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Central Nervous System: The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.

Walker 256/S carcinosarcoma causes osteoporosis-like changes through ectopical secretion of luteinizing hormone-releasing hormone. (1/191)

We have shown that Walker 256/S mammary carcinoma caused osteoporosis-like changes in young female rats, accompanied by low serum estradiol and hypercalciuria without changes in the serum levels of calcium, phosphorus, and parathyroid hormone-related peptide. In this study, we investigated the cause of bone loss after Walker 256/S inoculation into female 6-week-old Wistar Imamichi rats, focusing on the sex hormone balance in the host animal. Walker 256/S-bearing rats showed characteristic osteoporosis, with a significant increase in spleen weight and a significant decrease in uterine weight by 14 days after s.c. tumor inoculation. In the in vitro bone marrow culture, mineralized nodule formation ability decreased according to the time after tumor inoculation, and tartrate-resistant acid phosphatase-positive multinucleated cell formation increased at 7 days after tumor inoculation, but it began to decrease at 14 days after tumor inoculation. This indicates that after inoculation with Walker 256/S tumor, the progenitors of osteoblasts and ostroclasts lost their balance in the bone turnover, resulting in bone resorption. On the other hand, Walker 256/S carcinoma expressed luteinizing hormone-releasing hormone (LH-RH) mRNA, and in Walker 256/S-bearing rats, the serum LH-RH level increased significantly from 3 days after tumor inoculation, whereas in the healthy control rats, this level was very low. Consequently, the serum levels of follicle-stimulating hormone, luteinizing hormone, estradiol, and progesterone were significantly lower in the tumor-bearing rats than in the healthy control rats. Because the LH-RH gene is located in the long prolactin release-inhibiting factor (PIF) gene and mRNA amplified by reverse transcription-PCR in this study contained whole LH-RH and a part of PIF, the Walker 256/S tumor is thought to express PIF. Indeed, the serum prolactin level decreased in tumor-bearing rats. The serum level of growth hormone, one of the other pituitary hormones, was not changed. Moreover, the level of an osteolytic cytokine, tumor necrosis factor alpha, increased in the serum of Walker 256/S-bearing rats, although this may be a result of the immune response of the host animal to tumor growth as well as an enlarged spleen. In conclusion, the Walker 256/S tumor lowers estrogen secretion through ectopical oversecretion of LH-RH, and then osteolytic cytokines, such as tumor necrosis factor alpha, increase in tumor-bearing rats, escape the control of estrogen, and activate osteoclasts, resulting in bone loss in a short period.  (+info)

Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles. (2/191)

As part of a study of the effects of low-level radiation, 1,343 Beagles, including 671 males and 672 females, were evaluated over their full lifetime for the occurrence of mammary neoplasia; there were 139 control males and 138 control females and 532 irradiated males and 534 irradiated females. All nodules found in surgical specimens or at necropsy were evaluated histologically. The overall incidence, metastasis and recurrence rates, and contribution to mortality of mammary neoplasms were determined. Based on this unique opportunity to correlate morphologic characteristics with ultimate biological behavior of all mammary tumors in a defined canine population, we propose a histogenetically based reclassification of epithelial mammary tumors. Of the 672 female dogs, 70.8% (476) had at least one mammary neoplasm; 60.7% (408) had more than one. Two male dogs had mammary neoplasms. Of 1,639 mammary carcinomas in the 672 females, 18.7% (307) were classified as ductular carcinomas (arising from the small interlobular or intralobular ductules), whereas 80.7% (1,322) were classified as adenocarcinomas of other histogenetic origin. Of 73 fatal carcinomas, ductular carcinomas accounted for 48 fatalities (65.8%), whereas other adenocarcinomas accounted for only 20 fatalities (27.4%). Radiation had no effect on this ratio. Ductular carcinomas also had a higher rate of metastasis than did adenocarcinomas. Existing classifications of mammary carcinomas do not recognize the characteristic morphologic features, the degree of malignancy, and the prognostic importance of these ductular carcinomas. Metastasis rates did not differ between simple and complex carcinomas or between those lesions and adenocarcinomas in mixed tumors. True carcinosarcomas metastasized more frequently (100%, or 5/5) than did adenocarcinomas in mixed tumors (34.4%, or 22/64), emphasizing the importance of not lumping these tumors under the classification of malignant mixed tumors.  (+info)

Increased expression of ornithine decarboxylase messenger RNA in human esophageal carcinoma. (3/191)

Ornithine decarboxylase (ODC) is a key enzyme in the biosynthesis of polyamines, which are essential for cell proliferation. The purpose of this study was to evaluate ODC expression in human esophageal cancer at the mRNA level. Sixty-four pairs of primary esophageal cancers and normal esophageal epithelia were examined by reverse transcription-PCR for ODC mRNA expression. The ODC mRNA levels were higher in primary esophageal carcinoma than in adjacent normal esophageal epithelium in 58 (90.6%) of 64 cases. The tumor:normal (T:N) ratio of ODC mRNA expression in esophageal specimens has a significant correlation with tumor-node-metastasis staging (P = 0.043), lymph node metastasis (P = 0.039), vascular vessel invasion (P = 0.035), and histology (P = 0.034) of the tumor. In well- and moderately differentiated squamous cell carcinoma, the patients with a higher T:N ratio showed a significantly poorer prognosis (P = 0.027), and multivariate analysis also confirmed that the T:N ratio has a significant correlation with poor prognosis (P = 0.043). The steady-state of ODC mRNA overexpression in esophageal carcinoma implies that the ODC gene may play an important role in tumorgenesis in squamous epithelium. Furthermore, ODC mRNA expression may be used as a prognostic marker, especially for well- and moderately differentiated squamous cell carcinoma.  (+info)

Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. (4/191)

Carcinosarcomas of the uterus, ovaries, and fallopian tubes are highly aggressive neoplasms with incompletely understood histogenesis. Although recent immunohistochemical, cell culture, and molecular genetic studies all favor these cancers to be monoclonal in origin, the extent of intratumoral genetic heterogeneity in these tumors with divergent histology has not been reported previously. For this study, we microdissected a total of 172 carcinomatous or sarcomatous foci from 17 gynecological carcinosarcomas and analyzed allelic status with 41 microsatellite markers on chromosomal arms 1p, 1q, 3p, 4q, 5q, 6q, 8p, 9p, 10q, 11p, 11q, 13q, 16q, 17p, 17q, 18q, and 22q. With the exception of a single case with microsatellite instability, we found shared allelic losses and retentions among multiple individually dissected foci of each case, strongly supportive of the concept of a monoclonal origin for these neoplasms. In eight of these cases, we also found heterogeneous patterns of allelic loss at limited numbers of chromosomal loci in either the carcinomatous or sarcomatous components of the neoplasms. These heterogeneous patterns of allelic losses were consistent with either genetic progression or genetic diversion occurring during the clonal evolution of these neoplasms. In two cases, we found the specific patterns of genetic progression to be consistent with sarcomatous components of the neoplasms arising from carcinomatous components. We conclude that most of the gynecological carcinosarcomas have a monoclonal origin, and that genetic progression and diversion parallel the development of divergent phenotypes in these tumors. Because phenotypically divergent areas of the tumors share numerous genetic alterations, this divergence most likely occurs relatively late in the evolution of these tumors.  (+info)

Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components. (5/191)

Neoplasms with mixed carcinomatous and sarcomatous growth patterns occur in many organs and tissues. The pathogenesis of these cancers is thought to be either the result of two independent neoplastic processes merging to form a single tumor, or a neoplasm of monoclonal origin that develops phenotypic diversity. To address this issue, we characterized molecular alterations in separately microdissected epithelial and sarcomatous areas in three cases of pancreatic mucinous cystic neoplasms with sarcomatous stroma. Using microsatellite markers for six chromosomal loci commonly deleted in infiltrating ductal adenocarcinomas of the pancreas, we found genetic alterations to be virtually identical between the sarcomatous and epithelial components of two of the three neoplasms. In the third neoplasm, we found allelic losses and retentions to be identical at five of the six chromosomal loci, but at a single locus, we noted allelic loss in the neoplastic epithelial component but not the sarcomatous component. The same neoplasms were also analyzed for activating point mutations in codon 12 of the K-ras gene by using mutant-enriched polymerase chain reaction and allele-specific oligonucleotide hybridization. A K-ras mutation was identified in the epithelial component of one of the three neoplasms (the same tumor with an additional allelic loss in the neoplastic epithelial cells), but the sarcomatous component of this tumor was wild-type at codon 12 of K-ras, as were both components of the other two neoplasms. Overall, these results suggest a monoclonal origin with subsequent divergence of the neoplastic epithelial and sarcomatous portions of these neoplasms.  (+info)

A so-called carcinosarcoma of the gallbladder in a patient with multiple anomalies--a case report. (6/191)

The patient was a 65-year-old woman with a chief complaint of right upper quadrant pain. Under the diagnosis of gallbladder tumor, preduodenal portal vein and absence of the pancreatic tail, cholecystectomy was performed. Intraoperative findings resulted in a diagnosis of gallbladder tumor, absence of the pancreatic tail, presence of preduodenal portal vein, and malrotation of the intestine. Histological examination of the resected specimens showed a so-called carcinosarcoma. Carcinosarcoma of the gallbladder is a rare tumor of the hepatobiliary region. The present case differs from previously reported cases in its presentation with multiple anomalies including the presence of preduodenal portal vein. Many cases of preduodenal portal vein in an association with duodenal stenosis in children have been reported, but reports of cases of preduodenal portal vein in adult patients are rarely seen in the literature.  (+info)

A case report of sinonasal teratocarcinosarcoma. (7/191)

A sinonasal teratocarcinosarcoma (SNTCS) is a rare and aggressive malignant neoplasm histologically characterized by the combination of one or more epithelial elements and mesenchymal components. We report a case of a 78-year-old man with SNTCS involving the nasal cavity and paranasal sinuses. He complained of epiphora and exophthalmos with weight loss. Physical and diagnostic images resulted T4N0M0. The tumor was completely and widely resected via a trans-facial approach to perform total maxillectomy with orbital exenteration. The clinical presentation, pathologic features, and clinical course are described with a review of the literature.  (+info)

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. (8/191)

Adult, embryonic, and tumor tissues were grafted to the chorioallantoic membrane of the chick embryo to determine whether blood vessels originally within implants were reused in the establishment of a new blood supply. Grafts were examined daily by in vivo stereomicroscopy and in histologic sections. Colloidal carbon injections into the host vasculature served to confirm the precise onset of graft circulation; Preexisting tumor blood vessels disintegrated by 24 hours after implantation and revascularization occurred at 3 days by penetration of proliferating host vessels into the tumor tissue. Adult tissues did not revascularize, and the original graft vasculature progressively disintegrated during the 9 days of observation, Most embryonic tissues revascularized in 1 or 2 days by reperfusion of the existing graft vasculature. Anastomosis of host and graft blood vessels seemed to result from connections between newly formed vascular sprouts arising from both vasculatures. This study indicates that only tumor grafts acquire their blood supply solely by formation of new blood vessels from the host microvasculature. By contrast revascularization of normal tissues, when it does occur, is predominately the result of perfusion of the preexisting graft blood vessels.  (+info)

TY - JOUR. T1 - Carcinosarcoma in the cecum. AU - Ryu, Youngjoon. AU - Kim, Aeree. AU - Kim, Han Kyeom. AU - Lee, Beomjae. AU - Jung, Woonyong. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. AB - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. KW - ...
I JUST found my childhood friends post on Facebook telling me she is having a total hysterectomy today for Uterine Carcinosarcoma and Im heartbroken. I lost one schoolmate about 10 years ago to brain cancer (same as her Mom had died from about 10 years before her). And Ive had several friends at work have cancer, some have died. Ive had another childhood friend how battled breast cancer, a daughter-in-law who had a tonsil become cancerous about 10 years ago which is survived and continues to be cancer free today. I have just been reading everything I can on this horrible uterine cancer. There is no history in my own family of cancer at all but Im terrified, for my friend today having surgery and for myself.. Im now wondering if I might better have a hysterectomy as well. I have a very large uterus caused by 3 huge fibroids... but since there is no cancer in my family, Ive thought it okay to put off a hysterectomy and wait for menopause to shrink them down. Ive been in menopause for 3-4 ...
Uterine carcinosarcomas (previously called malignant mixed Müllerian tumors) are dedifferentiated (metaplastic) carcinomas comprised of carcinomatous and sarcomatous elements arising from a single malignant clone. They may represent a stable disrupti
Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries. Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, based on the observation that skin cancers and superficial malignant fibrous histiocytomas are commonly seen in patients with sun-damaged skin; second, the composition hypothesis, which suggests that the mesenchymal component represents a pseudosarcomatous reaction to the epithelial malignancy; third, the combination hypothesis, which suggests that both the epithelial and mesenchymal components of the tumor arise from a common ...
Herein we report a carcinosarcoma with distinct epithelial and mesenchymal components, at the morphological, immunohistochemical and ultrastructural levels. Moreover, the sarcomatous component was composed of cells reminiscent of smooth muscle differentiation and cells with osteoblastic appearance. Some authors classified as large bowel carcinosarcomas epithelial tumours with areas of sarcomatoid differentiation, weakly immunoreactive for cytokeratins and with no evidence of osteosarcomatous nor chondrosarcomatous differentation [12, 13, 20, 21]. According to Aramendi et al., these cases are not properly carcinosarcomas, but should be considered sarcomatoid poorly differentiated carcinomas [23]. In the present case, the sarcomatous component completely lacked any epithelial signs of differentiation; furthermore, we noted areas of osteosarcomatous differentiation and osteoid material deposition. The topographic distribution was remarkable for the complete separation of the two components. ...
Carcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. They are most commonly seen in the female genital tract. Rarely they arise from the gastrointestinal tract. We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. The most unique feature of this tumour is the presence of osteosarcomatous element. This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma ...
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components. Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1...
PRIMARY OBJECTIVES:. I. To assess the one year recurrence-free survival in patients with uterine carcinosarcoma treated with sandwich therapy-including defining the patterns of recurrence in patients with carcinosarcoma who were treated with this regimen.. II. To evaluate the toxicity and tolerability of pelvic radiation sandwiched between cycles of paclitaxel/carboplatin chemotherapy in patients with uterine carcinosarcoma.. III. To correlate surrogate endpoint biomarkers with progression-free survival and prognosis.. OUTLINE:. CHEMOTHERAPY (weeks 1-9, 14-22): Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for 3 courses during weeks 1-9 and 14-22.. RADIATION THERAPY (weeks 8-16): Patients undergo external beam pelvic radiation therapy once a day, 5 days a week for 5 weeks during weeks 8-13. Patients then undergo high dose radiation (HDR) brachytherapy or intensity-modulated radiation therapy (IMRT) ...
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process ...
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process ...
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old man was operated on for a polypoid tumor of the distal esophagus. Histologically, this tumor was composed of ductal structure
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WASHINGTON -- Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database suggested.
Objective: Uterine carcinosarcoma (UCS) is an aggressive malignancy, making up less than 5% of uterine cancers. Pharmacologic inhibition of ATR kinase synergistically enhances the ability of cisplatin to kill carcinoma cells of many solid tumor types and is further enhanced in ATM low carcinoma cells. It is unknown whether ATR inhibition (ATRi) offers a therapeutic opportunity in UCS. The goal of this study was to evaluate ATM expression in UCS tumors and determine the response of an ATM low UCS model to ATRi + cisplatin combination.. Methods: ATM expression was evaluated in full tissue sections from 74 UCS tumors by immunohistochemistry (IHC) with an ATM specific monoclonal antibody (clone Y170, Abcam), and was categorized as negative vs any positive staining in the carcinomatous (C) vs sarcomatous (S) components. In vitro models of UCS: SK-UT-1, SK-UT-1B, KLE, and RL95-2 cell lines were treated with an ATRi (AZD6738), cisplatin, and ATRi + cisplatin. ATM low models were generated in RL95-2 ...
Hepatocellular carcinoma Neoplasm of ovary Small cell lung cancer Renal cell carcinoma Malignant melanoma of skin Papillary renal cell carcinoma, sporadic Carcinoma of gallbladder Colorectal Neoplasms Ovarian Neoplasms Ovarian Serous Cystadenocarcinoma Adenocarcinoma of prostate Squamous cell carcinoma of lung Glioblastoma Transitional cell carcinoma of the bladder Uterine Carcinosarcoma Pancreatic adenocarcinoma Adenocarcinoma of lung Uterine cervical neoplasms Squamous cell carcinoma of the head and neck Neoplasm of breast Adenocarcinoma of stomach Neoplasm of brain Malignant neoplasm of body of uterus Brainstem glioma Oesophageal carcinoma Nasopharyngeal Neoplasms Carcinoma of colon Epidermal nevus Malignant melanoma ...
A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma Academic Article ...
Matsuo, K.;Takazawa, Y.;Ross, M.S.;Elishaev, E.;Podzielinski, I.;Yunokawa, M.;Sheridan, T.B.;Bush, S.H.;Klobocista, M.M.;Blake, E.A.;Takano, T.;Matsuzaki, S.;Baba, T.;Satoh, S.;Shida, M.;Nishikawa, T.;Ikeda, Y.;Adachi, S.;Yokoyama, T.;Takekuma, M.;Fujiwara, K.;Hazama, Y.;Kadogami, D.;Moffitt, M.N.;Takeuchi, S.;Nishimura, M.;Iwasaki, K.;Ushioda, N.;Johnson, M.S.;Yoshida, M.;Hakam, A.;Li, S.W.;Richmond, A.M.;Machida, H.;Mhawech-Fauceglia, P.;Ueda, Y.;Yoshino, K.;Yamaguchi, K.;Oishi, T.;Kajiwara, H.;Hasegawa, K.;Yasuda, M.;Kawana, K.;Suda, K.;Miyake, T.M.;Moriya, T.;Yuba, Y.;Morgan, T.;Fukagawa, T.;Wakatsuki, A.;Sugiyama, T.;Pejovic, T.;Nagano, T.;Shimoya, K.;Andoh, M.;Shiki, Y.;Enomoto, T.;Sasaki, T.;Fujiwara, K.;Mikami, M.;Shimada, M.;Konishi, I.;Kimura, T.;Post, M.D.;Shahzad, M.M.;Im, D.D.;Yoshida, H.;Omatsu, K.;Ueland, F.R.;Kelley, J.L.;Karabakhtsian, R.G.;Roman, L.D. "Significance of histologic pattern of carcinoma and sarcoma components on survival outcomes of uterine carcinosarcoma." Annals ...
A malignant tumor that is a mixture of carcinoma (cancer of epithelial tissue, which is skin and tissue that lines or covers the internal organs) and sarcoma (cancer of connective tissue, such as bone, cartilage, and fat). Can appear in uterine, ovarian, pancreatic locations. Also known as Mixed Mullerian Tumor.
Of 224 patients entered on this study, 30 were ineligible for a variety of reasons, leaving 194 evaluable patients. Early in the study, the dose of the combination regimen was reduced by 20% (1 day) because of toxicity. The investigational arms were balanced for age, grade, and Gynecologic Oncology Group performance status. Percentages of adverse effects reported in 191 patients receiving chemotherapy included (ifosfamide/cisplatin-ifosfamide) grade 3 or 4 granulocytopenia (36/60), grade 3 or 4 anemia (8/17), grade 3 or 4 central nervous system toxicity (19/14), and grade 3 or 4 peripheral neuropathy (1/12). Treatment may have contributed to the deaths of 6 patients treated with full doses of ifosfamide and cisplatin for 5 days. The proportion of patients responding to ifosfamide alone versus ifosfamide-cisplatin therapy was (0.36 versus 0.54) overall, 0.47 versus 0.61 for pelvic, 0.21 versus 0.54 for lung, and 0.33 versus 0.40 for other metastatic sites of measurable disease. The relative ...
The International Agency for Research on Cancer recently estimated that endometrial carcinoma is the commonest gynaecological cancer in the developed world,1 with a rising incidence in postmenopausal women. In 2007, 7536 new endometrial cancers were diagnosed in the UK, making it the fourth most common cancer in women after breast, lung, and colorectal cancers.2 Cancer of the endometrium is the commonest cancer of the uterine corpus (about 92%, the remainder being uterine carcinosarcomas and sarcomas), according to the Surveillance, Epidemiology and End Results programme of the US National Cancer Institute, which has collected data on cancer from various locations and sources since 1973.3 Cure is possible and the overall five year survival rate for all stages is currently around 80%. Most women present early in the course of the disease when cure is more likely, so primary care practitioners need to be vigilant for potential indicators. We discuss the epidemiology, diagnosis, and treatment of ...
Insight Biotechnology supply high quality reagents for cell and molecular biology, specializing in antibodies for medical research.
About a week later I visited a local gynocologist. With only the written ultrasound analysis in front of her and an external poke-around exam, the gyn told me that the ovary needed to be taken out immediately and at my age, I "didnt need the rest." She wanted to admit me for surgery four days later to do a total abdominal hysterectomy, and while I was on the operating table, the tissues would be sent to pathology. If any cancer was found, fatty tissue and lymph nodes would be removed, with the assistance of an attending local gyn-oncologist. She offered a prescription for Xanax. I demurred, saying that my husband and I had planned a weekend getaway - couldnt I do that - and that I would seek a second opinion at University of Pennsylvania. She reluctantly agreed, and the slight body language response suggested that I had slapped her in the face. For the interim, she ordered a CT scan and CA125 blood test, which I obtained right away ...
Throughout the reported case, we found recurrence within 2 months, and tumor progression was very rapid. However, there were no cases that progressed as rapidly as shown in our case. The cases reported so far mostly presented a polypoid pattern of the tumor in the CT or the pathology of the removed specimen (7 of 10 cases). Alternatively, in the present case, the tumor was flat on the bile duct and tumor growth showed an infiltrative pattern, usually shown in gallbladder carcinosarcoma. An infiltrative pattern may have poor prognosis compared with a polypoid pattern because polypoid types tend to arise earlier with obstruction of the bile duct and obstructive symptoms, which enable easier detection [14]. The present case shows very radical progression, thus having the possibility that multiple small hidden malignancies would go undetected preoperatively, as well as the histochemical features of a tumor, especially sarcomatoid cells, associated with poor prognosis. There are few references which ...
Torenbeek, R., Hermsen, M.A., Meijer, G.A., Baak, J.P. and Meijer, C.J. (1999) Analysis by Comparative Genomic Hybridization of Epithelial and Spindle Cell Components in Sarcomatoid Carcinoma and Carcinosarcoma Histogenetic Aspects. Journal of Pathology, 189, 338-343.
A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma (P204 ...
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recent …
In order to obtain new compounds with antitumoural action the N-(metaacylaminobenzoyl)-α-acylaminobenzoyl)-α-aminoacids 4-9 were prepared. Thesecompounds were subsequently converted into the corresponding δ2-oxazolin-5-ones 10-15,which in turn were submitted to a ring opening reaction with di-(β-chloroethyl)amine toafford the peptide supported N-mustards 16-21, which showed low toxicity and cytostaticactivity similar to that of sarcolisine against the Ehrlich ascite and Walker 253carcinosarcoma.
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
By Litzky, Leslie A * Context.-Sarcomatous pulmonary neoplasms are a rare and diagnostically challenging group of tumors. Primary pulmonary sarcomas must be distinguished from the more frequent occurrence of sarcoma metastatic to the lung, primary pulmonary sarcomatoid carcinoma, and diffuse malignant mesothelioma involving the lung. In current practice, the general availability of ancillary diagnostic techniques, such as immunohistochemistry and molecular analysis, can reliably classify many sarcomatoid lesions. Objective.-To review the literature and report on additional primary material about the application of immunohistochemistry and molecular analysis in the differential diagnosis pulmonary sarcomatous neoplasms. Data Sources.-Literature review of relevant articles indexed in PubMed (National Library of Medicine) between 1961 and 2007 and primary material from the authors institution. Conclusions.-This review discusses specific criteria for the diagnosis of primary lung sarcomas and ...
A paradigm shift has been observed with respect to the development of effective therapies involving the use of complementary drug combinations. The main focus of such therapies is to target all the tumor components and impair their function. Tyrosine kinase receptors, mitochondria and microtubule networks are some of the most common targets of cancer cells. This novel approach helps in elucidating the effects of therapeutic combination on each tumor component and results in unveiling of new anti-cancer mechanisms. These anti-cancer mechanisms in turn pave the path for development of new drugs and strategies to tackle with the condition. Combination therapies are used against complex disorders that have multiple causes along with multiple targets and many small molecule drugs are capable of addressing multiple targets. Multitargeted therapies is the emerging discipline resulting from the combination of chemogenomics and network biology. The market for multitargeted therapies exhibits impressive ...
PURPOSE: UC is a disease of the entire urothelium, characterized by multiplicity and multifocality. The clonal relationship among multiple UCs has implications regarding adjuvant chemotherapy. It has been investigated in studies of chromosomal alteration and single gene mutation. However, these genetic changes can occur in unrelated tumors under similar carcinogenic selection pressures. Tumors with high MSI have numerous DNA mutations, of which many provide no selection benefit. While these tumors represent an ideal model for studying UC clonality, their low frequency has prevented their previous investigation. MATERIALS AND METHODS: We investigated 32 upper and lower urinary tract UCs with high MSI and 4 nonUC primary cancers in 9 patients. We used the high frequency and specificity of individual DNA mutations in these tumors (MSI at 17 loci) and the early timing of epigenetic events (methylation of 7 gene promoters) to investigate tumor clonality. RESULTS: Molecular alterations varied among tumors
Adenofibroma is a benign tumor composed histologically of epithelial elements and mesenchymal stroma. Carcinosarcoma is a malignant neoplasm that contains eleme
Primary malignant tracheal tumors are rare, accounting for approximately 0.2 % of respiratory tract tumors yearly, with squamous cell carcinomas and adenoid cystic carcinomas accounting for two-thirds of these cases. Sarcomatoid carcinomas are a group of poorly differentiated non-small cell lung carcinomas containing a component of sarcoma or sarcoma-like (spindle and/or giant cell) differentiation, categorized into five morphologic subgroups. Spindle cell sarcomatoid carcinoma is a rare variant of sarcomatoid carcinomas, consisting of only spindle-shaped tumor cells. Only one other case has been reported as a primary tracheal tumor. We present a 75-year-old male, having progressive dyspnea and cough, with a spindle cell sarcomatoid carcinoma tumor visualized on chest computed tomography scan and confirmed with biopsy. Due to its low incidence, knowledge of treatment methods, prognostic factors, and etiology is limited thus approaches to eradication have widely varied. We are reporting the second
Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene. UBB is repressed in approximately 30% of high-grade serous ovarian cancer (HGSOC) patients and is a recurrent lesion in uterine carcinosarcoma and endometrial carcinoma. We identified ovarian tumor cell lines that retain UBB in a repressed state, used these cell lines to establish orthotopic ovarian tumors, and found that inducible expression of a UBC-targeting shRNA led to tumor regression, and substantial long-term survival benefit. Thus, we describe a recurrent cancer-specific lesion at the level of ubiquitin production. Moreover, these observations reveal the ...
The mean age of patients was 56.8 years (range, 46-73 years). The CT appearance of the tumor was similar for all our patients: Large mass, peripheral, heterogeneous density, with massive necrotic tissue component that strongly heightened after contrast injection; tumor had a locoregional extension with parietal and bone invasion (n = 5) and a distance extension (n = 4) to the adrenal glands. Pathological examination found a pleomorphic carcinoma (n = 3), a giant cell carcinoma (n = 1) and a carcinosarcoma (n = 2). Sarcomatoid carcinoma diagnosis was increased for the remaining patients without precision of histological subtype. ...
v.10, n.3, 1 Review Article Consensus regarding the diagnosis, prognosis and treatment of canine mammary tumors: benign mixed tumors, carcinomas in mixed tumors and carcinosarcomas Geovanni D. Cassali, Karine A. Damasceno, Angélica C. Bertagnolli, Alessandra Estrela-Lima, Gleidice... Read more » ...
Ovarian cancer is the second most common gynecologic malignancy, but the most lethal gynecologic cancer. Ovarian cancer is divided into Type I and Type II subgroups. Type I tumors include low-grade micropapillary serous carcinoma, mucinous, endometrioid, and clear cell carcinomas and are characterized by high frequency of KRAS, BRAF, PTEN, or beta-catenin mutations. Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors (carcinosarcomas) and undifferentiated carcinomas and are characterized by high genetic instability and high frequency of TP53 mutation. Using gene expression profiling, we found that Pax2, a transcription factor of the Pax gene family, is highly expressed in type I ovarian tumors but is less expressed in Type II tumors. Pax2 is one of the nine Pax genes which have a conserved DNA sequence motif called the paired box, a 128 amino acid domain in the amino-terminal portion of the protein. Pax2 regulates tissue development and cellular differentiation ...
PubMed:: Head and Neck Neoplasms[Mesh] OR (cancer[sb] AND (esophag*[tiab] OR face[tiab] OR facial*[tiab] OR gingiva*[tiab] OR head[tiab] OR hypopharyn*[tiab] OR jaw[tiab] OR jaws[tiab] OR laryn*[tiab] OR lip[tiab] OR lips[tiab] OR mandib*[tiab] OR mouth[tiab] OR nasopharyn*[tiab] OR neck[tiab] OR nose[tiab] OR oesophag*[tiab] OR oral*[tiab] OR oropharyn*[tiab] OR otorhinolaryn*[tiab] OR palatal*[tiab] OR palate[tiab] OR palatum[tiab] OR paranasal*[tiab] OR parathyr*[tiab] OR paroti*[tiab] OR pharyn*[tiab] OR salivar*[tiab] OR sublingual*[tiab] OR submandib*[tiab] OR throat[tiab] OR thyroid*[tiab] OR tongue[tiab] OR tonsil*[tiab] OR uadt[tiab] OR "upper aerodigestive tract"[tiab]));; Embase.com:: (head and neck tumor/exp OR hnscc:ab,ti,kw OR scchn:ab,ti,kw) OR ((neoplasm/exp OR adenoma*:ab,ti,kw OR anticarcinogen*:ab,ti,kw OR blastoma*:ab,ti,kw OR cancer*:ab,ti,kw OR carcinogen*:ab,ti,kw OR carcinom*:ab,ti,kw OR carcinosarcoma*:ab,ti,kw OR chordoma*:ab,ti,kw OR malignan*:ab,ti,kw OR ...
Synonyms for blastomata in Free Thesaurus. Antonyms for blastomata. 2 synonyms for blastoma: blastocytoma, embryonal carcinosarcoma. What are synonyms for blastomata?
Urogenital system development in mammals requires the coordinated differentiation of two distinct tissues, the ductal epithelium and the nephrogenic mesenchyme, both derived from the intermediate mesoderm of the early embryo. The former give rise to the genital tracts, ureters and kidney collecting duct system, whereas mesenchymal components undergo epithelial transformation to form nephrons in both the mesonephric (embryonic) and metanephric (definitive) kidney. Pax-2 is a transcriptional regulator of the paired-box family and is widely expressed during the development of both ductal and mesenchymal components of the urogenital system. We report here that Pax-2 homozygous mutant newborn mice lack kidneys, ureters and genital tracts. We attribute these defects to dysgenesis of both ductal and mesenchymal components of the developing urogenital system. The Wolffian and Mullerian ducts, precursors of male and female genital tracts, respectively, develop only partially and degenerate during ...
Purpose: Magnetic resonance imaging (MRI) is the gold standard in visualizing brain tumors and their effects on adjacent structures. However, no reliable information concerning different tumor components and borders between perifocal edema and infiltration areas can be received. The aim of the study was to establish and evaluate a multimodal imaging concept, in order to differentiate different biological tumor components and to determine tumor borders. Materials and Methods: 12 patients with cerebral gliomas (four low and eight high grade) received a
Folliculosebaceous cystic hamartoma (FSCH), first described by Kimura et al in 1991, is a rare cutaneous hamartoma composed of dilated folliculosebaceous units associated with mesenchymal elements. Some authors have presented evidence suggesting that this lesion is very closely related to trichofolliculoma.. Clinical presentation: Majority of lesions present as 0.5-1.5 cm papules or exophytic nodules. Lesions are usually rubbery to firm in consistency. Typically arise in adulthood but the giant variant appears to be congenital and enlarges during puberty. Site: Face or scalp, ear and upper back. ...
After a median duration of 6 months (range, 4-12 months), seven ALK-positive NSCLC patients developed acquired resistance to crizotinib. Three patients harbored secondary ALK mutations, including one patient with both mutations: L1196M (n = 2) and G1269A (n = 2). Of note, one patient displayed ALK gene copy number gain (4.1-fold increase compared with the pre-crizotinib specimen) and EGFR L858R mutation with high polysomy. The amphiregulin concentration was high in the supernatant fluid from five patients with malignant pleural effusion (116.4-18934.0 pg/ml). SNU-2535 cells derived from a patient who harbored the G1269 mutation were resistant to crizotinib treatment similar to H3122 CR1 cells. L1196M and G1269A mutant clones were less sensitive to crizotinib and ALK downstream signals were ineffectively suppressed in these clones ...
After a median duration of 6 months (range, 4-12 months), seven ALK-positive NSCLC patients developed acquired resistance to crizotinib. Three patients harbored secondary ALK mutations, including one patient with both mutations: L1196M (n = 2) and G1269A (n = 2). Of note, one patient displayed ALK gene copy number gain (4.1-fold increase compared with the pre-crizotinib specimen) and EGFR L858R mutation with high polysomy. The amphiregulin concentration was high in the supernatant fluid from five patients with malignant pleural effusion (116.4-18934.0 pg/ml). SNU-2535 cells derived from a patient who harbored the G1269 mutation were resistant to crizotinib treatment similar to H3122 CR1 cells. L1196M and G1269A mutant clones were less sensitive to crizotinib and ALK downstream signals were ineffectively suppressed in these clones ...
Sarcoma are rare malignant tumors of the soft tissues of the body, and/or of the bone. Very few doctors ever see a sarcoma in their lifetime, because of this it is recommended that patients with suspected sarcoma seek out specialists. Sarcoma Centers specialize in the diagnosis, staging, and treatment of these difficult cancers.
Primary pulmonary leiomyosarcomas are a rare malignant tumor with generally poor prognosis. They pose important problems of differential diagnosis especially with pulmona..
A retinoblastoma is a rare malignant tumor of the retina. It occurs as both hereditary and non-hereditary forms. It is seen typically in children who are below the age of 5 years.
Adenolipoma refers to a variant of a lipoma with entrapped eccrine or, rarely, apocrine units. We present 5 cases of cutaneous adenolipoma to demonstrate the spectrum of changes in the lipomatous and epithelial components. The cases include 3 lesions
A collision tumor involving a tracheal sarcomatoid carcinoma and a papillary thyroid carcinoma has never been reported in the literature. A 78-year-old female presented with a large neck mass and hoarseness. A fine needle aspiration demonstrated papillary thyroid carcinoma. Imaging revealed a right thyroid mass invading into the tracheal lumen with bulky ipsilateral lymphadenopathy. The patient underwent a total thyroidectomy, tracheal resection, and central and right neck dissections. Pathology demonstrated a tracheal sarcomatoid carcinoma invading the right thyroid, which had multifocal papillary thyroid carcinoma with central and lateral neck metastases. The patient subsequently received adjuvant chemoradiotherapy and radioactive iodine. We present a case of a tracheal sarcomatoid carcinoma colliding with a papillary thyroid cancer. Treatment modalities should address the most aggressive tumor, while being tailored to clinical picture, tumor histology, and patient preferences.
We have recently proposed to reclassify the pleomorphic subtype of epithelioid malignant pleural mesothelioma (MPM) as nonepithelioid (biphasic/sarcomatoid) histology because of its similarly poor prognosis. We sought to investigate whether preoperative maximum standardized uptake value (SUVmax) on...
TY - JOUR. T1 - Whole-exome sequencing of metaplastic breast carcinoma indicates monoclonality with associated ductal carcinoma component. AU - Avigdor, Bracha Erlanger. AU - Beierl, Katie. AU - Gocke, Christopher. AU - Zabransky, Daniel J.. AU - Cravero, Karen. AU - Kyker-Snowman, Kelly. AU - Button, Berry. AU - Chu, David. AU - Croessmann, Sarah. AU - Cochran, Rory L.. AU - Connolly, Roisin. AU - Park, Ben H.. AU - Wheelan, Sarah. AU - Cimino-Mathews, Ashley M. PY - 2017/8/15. Y1 - 2017/8/15. N2 - Purpose: Although most human cancers display a single histology, there are unusual cases where two or more distinct tissue types present within a primary tumor. One such example is metaplastic breast carcinoma, a rare but aggressive cancer with a heterogeneous histology, including squamous, chondroid, and spindle cells. Metaplastic carcinomas often contain an admixed conventional ductal invasive or in situ mammary carcinoma component, and are typically triple-negative for estrogen receptor, ...
Inclusion Criteria: - Patients with a histologically confirmed diagnosis of high-grade nonmucinous epithelial ovarian (serous, endometrial, clear cell, carcinosarcoma, an mixed pathologies), fallopian tube, or primary peritoneal cancer that is Stage III or IV according to the International Federation of Gynecology and Obstetrics (FIGO) or tumor, node and metastasis staging criteria. - All patients with Stage IV disease are eligible. This includes those with inoperable disease, those who undergo primary debulking surgery (complete cytoreduction (CC0) or macroscopic disease), or those for whom neoadjuvant chemotherapy is planned. - Patients with Stage III are eligible if they meet one or more of the following criteria: 1. High risk Stage IIIC disease. 2. Planning to receive neoadjuvant chemotherapy. - Patients must provide a blood sample for research at Screening. - Patient must provide sufficient tumor tissue sample (a minimum of 2 formalin-fixed paraffin embedded blocks) at Screening for ...
A fine needle aspiration biopsy (FNAB)) device was designed to utilize a steel spring located between the syringe and its plunger which exerts a constant negative pressure (auto-vacuum). In 43 rats inoculated with breast tumor cells the technique was compared with the standard procedure of FNAB (21 Sp1 and 22 Walker 256 carcinosarcoma). Malignant cells were cytologically confirmed in all cases. Sufficient material was obtained in 95% of FNAB by auto-vacuum system versus 86% by standard technique. The superior results obtained with the auto-vacuum system was seen for both soft and hard tumours ...
Mean uterine volume increased after 6 months of treatment and doubled at the end of the one-year study. An increased incidence of endometrial cancer and uterine sarcoma mostly malignant mixed Mullerian tumours has been reported in association with Nolvadex treatment. You should use an effective non-hormonal type of birth control -- such as condoms, a diaphragm along with spermicide, or a non-hormonal I.. The use of tamoxifen in combination with anastrozole as adjuvant therapy has not shown improved efficacy compared with tamoxifen alone. Nolvadex tamoxifen is a non-steroidal, triphenylethylene-based drug which displays a complex spectrum of oestrogen antagonist and oestrogen agonist-like pharmacological effects in different tissues.. Further, the accuracy, currency and completeness of the information available on this Web site cannot be guaranteed. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. ...
One of the main goals of immunotherapy is to generate cytotoxic T lymphocytes (CTL) that can recognize antigens that are specifically expressed on the tumors, thereby leading to tumor destruction. However, there is considerable molecular diversity in ovarian cancer, and a major factor limiting vaccine progress is the lack of well-characterized rejection antigens (13). IFNγ production and proliferation are clear signs of specific activation; however, they do not prove cytotoxic ability. Our paramount objective was to determine the ability of antigen-specific T cells to kill autologous target cells expressing HERV-K while ignoring benign or normal cells. Our cohort of samples provided us a unique opportunity to achieve this objective in that it allowed cytolytic activity of autologous target cells (instead of an established cancer line not specific to the patient) to be assessed. To this end, we prepared KSU-primed IVS cells from ovarian cancer patient Acc115 (a malignant mixed mullerian tumor; ...
Magnetic resonance imaging (MRI) confirmed the diagnosis and excluded vascular or lymphatic malformation. The patient was scanned with both hands and wrists together (palms facing) to demonstrate the asymmetrical fatty and vascular hypertrophy (Figures 4-7.). Discussion. MDL is a rare congenital, but non-hereditary, form of localised gigantism of the fingers or toes with progressive proliferation of all mesenchymal elements in the distribution of a sclerotome and a disproportionate increase in fibro-adipose tissue.1,2,3 It can involve both the upper extremities (usually in the distribution of the median nerve with the index and middle fingers most commonly involved) and the lower extremities (usually in the distribution of the medial plantar nerve).4 MDL is mostly unilateral, with lower limb involvement more common.. Accelerated soft-tissue and osseous growth in the involved region is self-limiting and usually terminates at puberty.5 MDL may be associated with syndactyly, polydactyly, ...
TY - JOUR. T1 - Gliosarcomas. T2 - Analysis of 11 cases do two subtypes exist?. AU - Salvati, Maurizio. AU - Caroli, Emanuela. AU - Raco, Antonino. AU - Giangaspero, Felice. AU - Delfini, Roberto. AU - Ferrante, Luigi. PY - 2005/8. Y1 - 2005/8. N2 - There are conflicting reports regarding gliosarcomas. The goal of this study is to examine clinical, radiological, surgical and therapeutic aspects of 11 patients with gliosarcoma. Between 1993 and 2001, 11 patients with cerebral gliosarcoma were treated at our Institute. Ten patients underwent surgery and one patient had stereotactic biopsy. Four patients received whole brain radiotherapy with 60Co, five underwent radiotherapy with LINAC extended 2 cm beyond the edema margins. One patient refused any additional treatment after surgery and one patient was not treated postoperatively for poor clinical conditions (KPS 40). Chemotherapy (temozolomide) was administered to four patients. Four patients had a prevalence of sarcomatous component that ...
Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals. Controversy exists as to the benefit of regularly following asymptomatic patients to look for distant metastases because even if one is found, the options for further management are limited. When a metastasis is limited to the lung in an asymptomatic patient with no locoregional recurrence, metastasectomy might provide some long-term benefit, although we cannot know for certain. We encountered such a case, and we opted for surgical resection rather than a conservative approach. There is a need for multicenter trials so that the management of such patients, be it active or conservative, can be evidence-based.. ...
Malignant cells from Melanoma (epitheliod & pleomorphic subtype) usually contain moderate amounts of cytoplasm, and cytoplasmic melanin pigment is identified in tumor cells. Melanin pigment may also be seen in macrophages. The cells exhibit moderate to marked nuclear pleomorphism and, in some cases, contain binucleate and multinucleate cells. Nuclear chromatin is finely or coarsely granular, and…
metastasis, ovary, non-normalized, bulk, CGAP, EST, LTI non-normalized, unknown developmental stage, size fractionated, directionally cloned, phagemid, oligo-dT primed, papillary ovarian carcinoma, serous ovarian tumor, clear cell ovarian tumor, spindle cell ovarian tumor, mixed tumors, mixed mullerian tumor of the ...
Squamous cell carcinoma (SqCC) and sarcomatoid carcinoma (SC) are rare subtypes of prostate cancer. We report a rare case with concurrence of SqCC, SC and adenocarcinoma in a relap[...] ...
Preliminary efficacy and safety results of savolitinib treating patients with pulmonary sarcomatoid carcinoma (PSC) and other types of non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping ...
Note 1: AJCC 7th Edition TNM staging reflects the new staging adopted by the Federation Internationale de Gynecologie et dObstetrique (FIGO) and utilizes three new staging schemas for cancer of the Corpus Uteri based on histology. This is a change from the AJCC 6th Edition TNM staging. The three new schemas are: 1. Carcinoma and carcinosarcoma 2. Leiomyosarcoma and endometrial stromal sarcoma (ESS) 3. Adenosarcoma ...
CD8+ tumor-infiltrating lymphocytes as a novel prognostic biomarker in lung sarcomatoid carcinoma, a rare subtype of lung cancer Jiewei Chen,1,2,* Qingmei He,2,* Jun Liu,1,2,* Yongbo Xiao,1 Canhua Xiao,3 Keming Chen,1 Dan Xie,1,2 Xinke Zhang1,2 1Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, People’s Republic of China; 3Department of Pathology, Qingyuan People’s Hospital, Qingyuan, 511581, People’s Republic of China *These authors contributed equally to this work Purpose: The aim of this study was to investigate the degree of infiltration of CD8+ tumor-infiltrating lymphocytes (TILs) including high and low density in lung sarcomatoid carcinoma (LSC) and their clinicopathological significance.Patients and methods: The density of CD8+ TILs in paraffin-embedded
Diktyoma, or ciliary body medulloepithelioma, or teratoneuroma, is a rare tumor arising from primitive medullary epithelium in the ciliary body of the eye. Almost all diktyomas arise in the ciliary body, although, rarely, they may arise from the optic nerve head or retina. The name "diktyoma" comes from its characteristic findings on histology. Diktyoma is classified into teratoid and nonteratoid types, based on heteroplastic tissue in the former. Each type may be sub-classified as benign or malignant based on histology. Based on histology, the tumor is classified as malignant if it contains poorly differentiated neuroblasts, nuclear pleomorphism, markedly abnormal mitotic activity, sarcomatous components, or invasion into the uvea, cornea, or sclera. Most diktyomas are malignant. The most common symptoms of diktyoma are vision loss and pain, while the most common signs are leukocoria and presence of a mass in the iris or ciliary body. Other signs and symptoms include lens subluxation, glaucoma, ...
Soft tissue sarcoma of the intra-abdominal organ is a rare malignant tumor and leiomyosarcoma is its most common histologic type [3]. Regardless of the histologic type, however, surgical resection is considered standard therapy [1]. There have been few studies of distant metastases that occur after the complete resection of a primary leiomyosarcoma. There is no generally accepted treatment for this either, especially for a liver metastasis, although surgery remains the mainstay, because leiomyosarcoma is relatively chemoresistant and radioresistant [4]. There have been few case reports of primary or metastatic leiomyosarcoma of liver [5]. Faraj et al. [4] reported five cases of liver resection for metastatic colorectal leiomyosarcoma, with a median survival of 47 months. Akwari et al. [6] reported 108 cases of intestinal leiomyosarcoma, but with no mention of the management of these metastases. McGrath et al. [7] analyzed 51 cases of primary gastrointestinal sarcoma (virtually all were ...
Muscle sarcoma. Section through human thigh muscle showing a cancerous tumour or sarcoma. The tumour has been sliced in two (white ovals); thigh muscle is red. The scale reference is in centimetres. Sarcomas are cancers of the connective tissue (muscle, bone, nerves). A sarcoma affecting skeletal (voluntary) muscle, as is the muscle of the thigh, is termed a rhabdomyosarcoma. It is a rare malignant tumour. It commonly affects the large muscle of the arm or leg in patients of old age. The tumour grows rapidly and spreads to other tissues. Rhabdomyosarcoma responds poorly to treatment by radiotherapy and anticancer drugs. Surgical removal is usually necessary. - Stock Image M131/0183
A few models have been established to study cancer cells in vitro. However, the cellular interactions have rarely been studied specifically using bioengineered cancer constructs combining human carcinoma cells and tumor-associated fibroblasts. We developed an in vitro model of tridimensional bioengineered cancer tissue constructs (bCTC) by seeding mammary epithelial cancer cells or normal keratinocytes over a mesenchymal layer containing tumor-derived fibroblastic cells or normal skin fibroblasts. After the introduction of epithelial cells, each construct was cultured for another 10 d. Histologic analyses showed that carcinoma cell lines could invade the subjacent mesenchymal layer and that the capacity to migrate was related to the invasive potential of cancer cells and the type of fibroblasts used, while noninvasive populations did not. Of the tested epithelial cells, MDA-MB-231 and, to a lesser degree, HDQ-P1 cell lines were invasive, and the invasion was deeper into the mesenchymal component ...
Glomangiosarcoma is an extremely rare neoplasm of soft tissue. It originated from a benign glomus tumor. We report a case of glomangiosarcoma occurring on the skin over the left scapular area of a 71-year-old man. The tumor was a dull-red, raised and tender nodule with a maximum diameter of 1 cm. Histologically, the skin lesion revealed a sarcomatous nodule that was surrounded by benign glomus cells at the periphery. In immunohistochemical studies, the tumor cells stained intensely and diffusely ..................More ...
Background & Objective: Chronic non healing ulcers or scar undergoing malignant transformation is a rare phenomenon with an estimated incidence of 2%. Though, numerous predisposing factors have been identified, still it is rarely diagnosed and commonly mistaken for a benign condition. The objective of this study was to verify the efficacy of the Fine Needle Aspiration Cytology/ Scrape cytology of chronic non healing ulcers, and its use in the early detection of the malignant transformation, thereby facilitating early management. Methods: A total of 10 cases of chronic non healing ulcer with malignant transformation were included in the study where the initial diagnosis was made on Fine Needle Aspiration Cytology/Scrape cytology and later on confirmed on histopathology. Results: Squamous cell carcinoma (7 cases), acantholytic variant of Squamous Cell Carcinoma (1 case), malignant fibrous histiocytoma (1 case) and carcinosarcoma (1 case) was seen. A 100% concordance with histopathology was seen in
An increased incidence of uterine malignancies has been reported in association with tamoxifen treatment. The underlying mechanism is unknown, but may be related to the estrogen-like effect of tamoxifen. Most uterine malignancies seen in association with tamoxifen are classified as adenocarcinoma of the endometrium. However, rare uterine sarcomas, including malignant mixed mullerian tumors (MMMT), have also been reported. Uterine sarcoma is generally associated with a higher FIGO stage (III/IV) at diagnosis, poorer prognosis, and shorter survival. Uterine sarcoma has been reported to occur more frequently among long-term users (greater than or equal to 2 years) of tamoxifen citrate than non-users. Some of the uterine malignancies (endometrial carcinoma or uterine sarcoma) have been fatal.. In the NSABP P-1 trial, among participants randomized to tamoxifen there was a statistically significant increase in the incidence of endometrial cancer (33 cases of invasive endometrial cancer, compared to 14 ...
TY - JOUR. T1 - Hepatocellular Carcinoma Containing Sarcomatous Lesions in a Normal Liver, Accompanied by Secondary Budd-Chiari Syndrome [1]. AU - Kishino, Tomonori. AU - Mori, Hideaki. AU - Nishikawa, Kaori. AU - Ishiyama, Narihiro. AU - Yasui, Hideaki. AU - Sugiyama, Masanori. AU - Atomi, Yutaka. AU - Sakamoto, Michiie. AU - Saito, Shozo. AU - Ishida, Hitoshi. AU - Takahashi, ShinIchi. AU - Watanabe, Takashi. PY - 2004/3. Y1 - 2004/3. UR - http://www.scopus.com/inward/record.url?scp=10744233167&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=10744233167&partnerID=8YFLogxK. U2 - 10.1097/00004836-200403000-00019. DO - 10.1097/00004836-200403000-00019. M3 - Article. C2 - 15128080. AN - SCOPUS:10744233167. VL - 38. SP - 296. EP - 297. JO - Journal of Clinical Gastroenterology. JF - Journal of Clinical Gastroenterology. SN - 0192-0790. IS - 3. ER - ...
Background: Gliosarcoma refers to an uncommon astrocytic tumor of the central nervous system. These tumors include both glial and mesenchymal components by definition, and are extremely malignant. Gliosarcomas are particular to tumors with distinct gliomatous and sarcomatous constituents, and are distinguished from gliobastomas which have undergone mesenchymal metaplasia. Gliosarcomas encompass 2-8% of all glioblastoma cases and tend to occupy the supratentorial regions of the brain, especially the temporal lobe. Rare infratentorial lesions including the cerebellar hemisphere, intraventricular, and multi-focal tumors have also been reported. Accurate neuroimaging diagnosis is critical and diffusion tensor imaging (DTI) and spectroscopy can be useful to differentiate from inflammatory disease. Methods: We report a 38 year-old Caucasian male with a right parietal lobe glioblastoma. The patient presented with new onset tonic-clonic seizures lasting approximately five minutes associated with postictal
Physiological changes in postnatal and aging lung are associated with a variety of microscopic changes in the lung, especially the alveolar lung tissue, both in the interstitial and epithelial component. Interstitial tissue of the lung will increase in thickness that is supposed to be due to changes in fiber composition, particularly collagen. However, the exact changes are still under debate and the underlying process is still unclear. The epithelial component that experiences changes is type II alveolar cells or pneumocyte II (surfactant producing cells). The ratio of pneumocyte II against pneumocyte I is expected to decline with age. This decrease will certainly affect their function in maintaining pulmonary surfactant supply. To maintain normal vital functions and synthesis of surfactant, lung tissue is also dependent on the availability of glucose because glucose is the fundamental building blocks of glycerol backbone of surfactant. In the aging process, accumulation of glycogen in the brain,
We report a case of primary sarcoma of the skin with a biphasic histological pattern, being composed of areas of mixed mesenchymal-epithelial cell proliferation and areas of purely sarcomatous growth. The tumor occurred in the posterior cervical region of a 93-year-old man, and its history was marked by sudden, rapid enlargement after many years of stable duration. The excised lesion was about 4 cm in diameter, had a firm consistency and was covered by intact skin. Histological examination showed a multifocal proliferation of follicular germinative cells arranged in corymbiform and petaloid shapes with an overall retiform growth pattern. Epithelial cords and strands were composed of cytologically uniform cells with bland nuclear features and were surrounded by a prominent, fibroblast-rich stroma reminiscent of a perifollicular sheath. In many areas of the tumor the stroma showed abrupt transition into a pleomorphic proliferation of large sarcomatous cells with frequent and often atypical ...
Diagnosis: Endometriosis at the incision site.. Discussion: Endometriosis of the skin and soft tissue tend to occur at sites of prior surgical scars resulting from the spillage of endometrial tissue during surgery. The incidence of endometriosis at the site of prior C-section scar is estimated to be less than 0.1%. They typically present 2-8 years later with nodules around the surgical tract. History of a slow growing mass with cyclical pain may be elicited. Endometriosis needs to be differentiated from other benign and malignant lesions and for possible malignant transformation. The main differential diagnoses include metastatic well differentiated endometrioid adenocarcinoma, low grade endometrial stromal sarcoma and malignant mixed mullerian tumor.. The diagnosis of endometriosis is established by the triad of hemosiderin-laden macrophages, endometrial glands and spindle cell stroma. Unfortunately on cytology, all three components are rarely present and may erroneously suggest a purely ...
Glomangiosarcoma- Patient with glomangiosarcoma usually developed widespread metastases.. Microscopic features: Histologically, the features are those of benign glomus tumour with sarcomatous areas consisting of short spindle cells with hyperchromatic nucleus (round cell or leiomyosarcomatous appearance) and prominent mitotic figures.. II Classification of atypical glomus tumours: (Folpe et al.) 1. Malignant ; 2. Symplastic ; 3. Glomus tumors of uncertain malignant potential, and 4. Glomangiomatosis. Atypical glomus tumour: Glomus tumours display unusual features, such as large size, deep location, infiltrative growth, mitotic activity, nuclear pleomorphism, and necrosis. Atypical features are usually observed centrally with a rim of benign-appearing glomus tumour.. Malignant glomus tumour: Tumour with a deep location and a size of more than 2 cm, or atypical mitotic figures, or moderate to high nuclear grade and 5 mitotic figures or more/50 HPF. High nuclear grade alone, infiltrative growth, ...
TY - JOUR. T1 - Successful treatment of unresectable advanced hepatoblastoma. T2 - Living liver transplantation after surgical removal of lung metastasis. AU - Miyamura, Takako. AU - Yoshida, Ryuichi. AU - Yagi, Takahito. AU - Matsukawa, Hiroyoshi. AU - Chayama, Kousuke. AU - Ishida, Toshiaki. AU - Washio, Kana. AU - Morishita, Naoto. AU - Oda, Megumi. AU - Morishima, Tsuneo. PY - 2011/8. Y1 - 2011/8. N2 - Hepatoblastoma is a rare malignant tumor of the liver in children. Intensive combination chemotherapy has increased the number of surgically resectable cases and improved prognosis markedly. However, unresectable cases and cases with residual metastasis, including lung metastases, have a poor prognosis. In these refractory cases, treatment strategy has not been established. On the other hand, living liver transplantation has been shown to be effective in cases of advanced hepatoblastoma, but its effectiveness in cases with residual distant metastases after chemotherapy remains unclear. We ...
U.S. researchers say theyve identified the molecular trigger of fibroid uterine tumors -- a single stem cell develops a mutation and grows uncontrollably.
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Lipomatous Uterine Tumors
Extreme leukocytosis and leukemoid reaction associated with the lung sarcomatoid carcinoma: an unusual case report Danyang Wang, Haiyan Zhang, Fengkuan Yu, Baijun Fang Department of Hematopathy, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China Purpose: To report a rare case of extreme leukocytosis and leukemoid reaction associated with lung sarcomatoid carcinoma (LSC) and increase people’s awareness of the disease. Patients and methods: A 58-year-old male patient was diagnosed with LSC; however, after the end of the second course of chemotherapy, his white blood cells increased gradually without fever or use of medications such as granulocyte colony-stimulating factor and steroids. A bone marrow biopsy then confirmed it to be a leukemoid reaction. Results: The patient died of multiple organ failure 2 months after being diagnosed with leukocytosis. Conclusion: LSC associated with leukemoid reaction is very rare and the prognosis is
INTRODUCTION: Ameloblastic fibro-odontosarcoma is an extremely rare subtype of odontogenic sarcoma, with only 13 cases reported in the literature.. CASE REPORT: A 4-year-old male presented with a painless mandibular swelling, which appeared 4months previously. Cone beam computed tomography revealed an extensive, ill-circumscribed, multilocular radiolucency of the right mandible extending from the first deciduous molar to the ramus with slightly dense opacities. Histological examination of the incisional biopsy specimen revealed a biphasic tumor with sarcomatous mesenchyme and benign ameloblastic epithelial component compatible with a diagnosis of ameloblastic fibrosarcoma. A right hemimandibular resection was performed. Areas of deposition of dentinoid and enamel material closely adjacent to ameloblastic epithelium were noted in the excised specimen. A final diagnosis of ameloblastic fibro-odontosarcoma was made. After four years of close follow-up, there is no sign of recurrence or ...
Ameloblastic fibrosarcoma is a rare tumor and only the mesenchymal component shows features of malignancy but the epithelial compoment remains (...)
Results.-Glucose transporter-1, p53, insulin-like growth factor 2 messenger RNA-binding protein 3 (IMP-3), desmin, and epithelial membrane antigen have all been claimed to mark either benign or malignant mesothelial processes, but in practice they at best provide statistical differences in large series of cases, without being useful in an individual case. Homozygous deletion of p16 by FISH or loss of BAP1 has only been reported in malignant mesotheliomas and not in benign mesothelial proliferations. BAP1 appears to be lost more frequently in epithelial than mixed or sarcomatous mesotheliomas. Homozygous deletion of p16 by FISH is seen in pleural epithelial, mixed, and sarcomatous mesotheliomas, but it is much less frequent in peritoneal mesothelioma. The major drawback to both these tests is limited sensitivity; moreover, failure to find p16 deletion or BAP1 loss does not make a mesothelial process benign ...
Disease Overview Thymomas and thymic carcinomas are epithelial tumors of the thymus. The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. A thymic epithelial tumor that exhibits clear-cut cytologic atypia and histologic features no longer specific to the...
1. Richmond T Prehn, Lisa M Prehn. Cancer Immunotherapy by Immunosuppression. Theoretical Biology and Medical Modeling. 2010;7:45 2. Prehn RT. The initial immune reaction to a new tumor antigen is always stimulatory and probably necessary for the tumors growth. Clin. Dev Immunol. 2010;2010:851728 3. DOnofrio A, Gatti F, Cerrai P & Freschi L. Delay-induced oscillatory dynamics of tumor-immune system interaction. Math and Computer Model. 2010;51:572- 591 4. Carpenter AC & Bosselut R. Decision checkpoints in the thymus. Nature Immunology. 2010;11(8):666-673 5. Ludford RJ, Barlow H. Sarcomatous transformation of the stroma of mammary carcinomas that stimulated fibroblastic growth in vitro. Cancer Research. 1943;5:257-264 6. Ludford RJ, Barlow H. The influence of malignant cells upon the growth of fibroblasts in vitro. Cancer Research. 1994;8:694-703 7. Kasuta H, Takaota T, Nagai Y. Interaction in culture between normal and tumor cells of rats. In: (ed.) Kasuta H. Cancer Cells In Culture. Tokyo, ...
There are different types of treatment for patients with uterine sarcoma.. Different types of treatments are available for patients with uterine sarcoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.. Four types of standard treatment are used:. Surgery. Surgery is the most common treatment for uterine sarcoma, as described in the Stages of Uterine Sarcoma section of this summary.. Even if the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy ...
Abstract. Background: Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells lose cell-cell contacts and acquire expression of mesenchymal components and manifest a migratory phenotype. Recent studies indicated that EMT is involved in the development of keloids. Therefore, this study aims to investigate the mechanisms of the effects of metformin in hypoxia-induced EMT in keloid fibroblasts (KFs).. Methods: KFs were cultured in a hypoxia incubator to induce EMT and were treated with or without metformin. Cell viability was evaluated by a cell counting kit 8 (CCK-8), and cell migration was measured by the transwell assay. The expression levels of HIF-1α, E-cadherin, vimentin, phosphorylated p70s6k (p-p70s6k) and pyruvate kinase M2 (PKM2) were evaluated by western blotting.. Results: Hypoxia promoted EMT in KFs. Metformin significantly inhibited the expression of HIF-1α and partially abolished hypoxia-induced EMT. PKM2 is involved in hypoxia-induced EMT of KFs and ...
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A carcinoma that arises from the gallbladder. It is characterized by the presence of glandular and squamous malignant epithelial components.
Contents: 1. Cytology of the uterine cervix and corpus M. Fujiwara and C. S. Kong; 2. Cervix: squamous cell carcinoma and precursors M. Fujiwara and C. S. Kong; 3. Cervix: adenocarcinoma and precursors, including variants; 4. Miscellaneous cervical abnormalities; 5. Nonneoplastic endometrium; 6. Endometrial carcinoma precursors: hyperplasia and EIN; 7. Endometrioid adenocarcinoma; 8. Serous adenocarcinoma; 9. Other uterine corpus carcinomas, including variants; 10. Carcinosarcoma; 11. Adenofibroma and adenosarcoma; 12. Uterine smooth muscle tumors; 13. Endometrial stromal tumors; 14. Other uterine mesenchymal tumors; 15. Miscellaneous primary uterine tumors; 16. Uterine metastases: cervix and corpus; 17. Gestational trophoblastic disease; 18. Other pregnancy-related abnormalities; 19. Lynch syndrome (hereditary nonpolyposis colon cancer syndrome); 20. Cytology of peritoneum and abdominal washings C. Haynes and C. S. Kong; Index.. ...
Pulmonary MGA with lack of bronchial relation is extremely unusual.4 Moreover, MGA of the peripheral lung with cartilage islands has not been reported.. The histologic findings of a benign mucous glandular proliferation mixed with cartilage/mesenchymal component suggest several possible scenarios. First, it is reasonable that MGA with myxoid stroma develops chondroid metaplasia, as occurs in other organs. The stroma of MGAs varies, and hyalinized sclerosis can be seen.2 However, no report describing myxoid stroma and cartilage islands in MGA could be found in the English literature.. We also considered coincidental combination of MGA and pulmonary hamartoma. There was a case report of a collision tumor of pulmonary hamartoma and a carcinoid.5 However, this was likely an extremely extraordinary situation, considering the rarity of mucus gland adenoma.. There have been two reported cases of salivary gland-type tumors developed in hamartoma; myoepithelioma and malignant mixed tumor.6 The ...
IVLBCL is a rare malignant tumor that progresses rapidly and that may involve any organ, and IVLBCL involving the thyroid is particularly rare [2]. Depending on the organ involved, the clinical presentations of IVLBCL are non-specific and unpredictable, and may include neurological signs and symptoms, cutaneous lesions, fever, hepatosplenomegaly and cytopenia [5, 7, 15]. Given the high variance of clinical presentation, most patients undergo many investigations before the diagnosis is established. Occasionally, patients cannot be diagnosed or treated promptly as a result of the lack of sensitive diagnostic methods [5].. The patient in this case suffered from dyspnea and intermittent headaches for approximately 1 month. A giant non-tender mass in the neck was accidentally discovered upon physical examination. A CT scan demonstrated that the remarkably enlarged left lobar thyroid was occupied by a giant mass that suppressed the trachea. Thyroid function tests were normal preoperatively, whereas ...
While endometrial cancer and uterine sarcoma are similar, they have different symptoms. Learn what the difference is between endometrial cancer and uterine sarcoma.
American Institutes for Research (AIR) offered to provide in-kind support for usability testing the WAI Web site. The WSTF is incorporating usability testing with the WAI Web Site Redesign Project. AIR provided an early Draft Usability Test Plan and Protocol, which will be modified based on the information below as it is finalized.. This first test of the current WAI Web site is limited by many constraints, e.g., 8 participants in Concord, MA, USA. We expect to conduct much broader testing of early redesign prototypes with more people, with people with more disabilities, in different countries, etc.. ...
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Thymoma and thymic carcinoma originate within the epithelial cells of the thymus, resulting in an anterior mediastinal mass. The term thymoma is customarily used to describe neoplasms that show no overt atypia of the epithelial component, whereas, a thymic epithelial tumor that exhibits clear-cut cytologic atypia and...
Carcinosarcoma no Malignant Mullerian Mixed tumors; metaplastic carcinoma [18] Sarcoma botryoides no botryoid sarcoma, botryoid ...
carcinosarcoma, ICD-O 8980/3). *złośliwy guz rabdoidalny (malignant rhabdoid tumor, ICD-O 8963/3) ...
Sarcomas and carcinosarcomas carry an average survival time of nine to twelve months.[9] Inflammatory carcinomas have a very ... Malignant mammary tumors are divided into sarcomas, carcinosarcomas, inflammatory carcinomas (usually anaplastic carcinomas), ...
Carcinosarcoma Sarcoma Low mag. Intermed. mag. Very high mag. Verschraegen, CF.; Vasuratna, A.; Edwards, C.; Freedman, R.; ... Most tumours are discovered at an early stage and have a good prognosis, especially when compared to uterine carcinosarcoma. ...
Chiu, KC; Lin, MC; Liang, YC; Chen, CY (2008). "Renal carcinosarcoma: case report and review of literature". Renal Failure. 30 ...
... uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer. TCGA accrued samples ... "Integrated Molecular Characterization of Uterine Carcinosarcoma". Cancer Cell. 31 (3): 411-423. doi:10.1016/j.ccell.2017.02.010 ...
Chiu KC, Lin MC, Liang YC, Chen CY (2008). "Renal carcinosarcoma: case report and review of literature". Ren Fail. 30 (10): ... Clear cell adenocarcinoma Transitional cell carcinoma Inverted papilloma Renal lymphoma Teratoma Carcinosarcoma Carcinoid tumor ...
"Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma". The Journal of Pathology. 223 (1 ...
Carcinosarcomas comprise both malignant epithelial and malignant sarcomatous components. Leiomyosarcomas are now staged using ... Tumoral entities include leiomyosarcomas, endometrial stromal sarcomas, carcinosarcomas and "other" sarcomas. If the lesion ...
The differential includes leukemia, lymphoma, high-grade carcinoma, carcinosarcoma, and differentiated pure sarcomas. Polypoid ...
Type II cancers are of higher histological grade and include serous carcinoma and carcinosarcoma. Surface epithelial-stromal ...
"Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic ...
... including carcinosarcoma and pulmonary blastoma. A history of cigarette smoking is the most common cause of large cell ...
Other less common liver cancers include carcinosarcomas, teratomas, yolk sac tumours, carcinoid tumours and lymphomas. ...
... uterine carcinosarcoma, uveal melanoma, thymoma, sarcoma, mesothelioma, and testicular germ cell cancer. Within the context of ...
... carcinosarcoma, and pulmonary blastoma, which are (arguably) related variants. While the 4th revision ("WHO-2004") retained the ...
2002). "Cancer-testis antigen expression in uterine malignancies with an emphasis on carcinosarcomas and papillary serous ...
... and ellagic acid effects on the radiation-sensitized walker 256 rat carcinosarcoma, Radiat. Res., 36(1), 166-79 (1968). D. ...
... carcinosarcoma, and pulmonary blastoma.. ...
... carcinosarcomas), or mesenchymal tumours. Traditional classification of endometrial carcinomas is based either on clinical and ...
There is debate over the naming of MMMT; the term carcinosarcoma was formerly used to describe lesions with homologous tumors, ... While "carcinosarcoma" now considered standard, "malignant mixed Müllerian tumor" has a lengthy history within gynecological ... A malignant mixed Müllerian tumor, also known as malignant mixed mesodermal tumor, MMMT and carcinosarcoma, is a malignant ...
... familial Otosclerosis Otospondylomegaepiphyseal dysplasia Ouvrier-Billson syndrome Ovarian cancer Ovarian carcinosarcoma ...
... carcinosarcoma MeSH C04.557.450.795.290.210 --- carcinoma 256, walker MeSH C04.557.450.795.300 --- chondrosarcoma MeSH C04.557. ... carcinosarcoma MeSH C04.557.435.290.210 --- carcinoma 256, walker MeSH C04.557.435.380 --- hepatoblastoma MeSH C04.557.435.500 ...
... specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma Mammary analogue secretory carcinoma Carcinosarcoma ...
... carcinosarcoma, or (5) pulmonary blastoma. Lung cancer is a large and exceptionally heterogeneous family of malignancies. Over ...
... and taxodione possess in vivo activity against Walker intramuscular carcinosarcoma 256 in rats (25 and 40 mg/kg, ...
title = "Carcinosarcoma in the cecum",. abstract = "Carcinosarcoma of the colon is rare. Seventeen cases have been reported in ... Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the ... Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the ... Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the ...
Carcinosarcoma of the prostate is also known as sarcomatoid carcinoma [1-4]. This malignancy has a very poor prognosis, with a ... The diagnosis of prostatic carcinosarcoma was confirmed by Johns Hopkins University, with a Gleason Grade . Metastatic workup ... Prostatic Carcinosarcoma with Lung Metastases. Stefanie R. Furlan,1 David J. Kang,1 and Armando Armas2 ... In some publications, carcinosarcoma may also be referred to as sarcomatoid carcinoma [1-4]. There are fewer than 100 reported ...
carcinosarcoma synonyms, carcinosarcoma pronunciation, carcinosarcoma translation, English dictionary definition of ... n a malignant tumour composed of carcinoma and sarcoma Noun 1. carcinosarcoma - a malignant neoplasm composed of carcinoma and ... carcinosarcoma. Also found in: Thesaurus, Medical, Wikipedia. carcinosarcoma. (ˌkɑːsɪnəʊˈsɑːkəʊmə) n. a malignant tumour ... Prostatic carcinosarcoma is a rare malignancy composed of sarcomatous and carcinomatous elements.. Prostatic Carcinosarcoma: A ...
Renal carcinosarcoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ...
Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database ... Carcinosarcomas are malignant mixed mullerian tumors. Carcinosarcomas that arise in the female genital tract are rare but ... They found a total of 3,683 cases, including 2,759 women with uterine carcinosarcomas and 924 with ovarian carcinosarcomas. ... Women with uterine carcinosarcomas were slightly older (median age 67.6 versus 65.8, P,0.001), were more likely to be African ...
... C. Iavazzo, F. Kokka, A. Sahdev, N. Singh, and K. Reynolds ... We present a case of a patient with carcinosarcoma arising in a didelphys uterus. Case. A 73-year-old patient presented with ... Tissue was sent for biopsy which revealed high-grade uterine carcinosarcoma. Two uterine fundi and two vaginas in keeping with ... According to our knowledge, this is the second case of carcinosarcoma arising in didelphys uterus in the world literature. ...
Uterine carcinosarcomas (previously called malignant mixed Müllerian tumors) are dedifferentiated (metaplastic) carcinomas ... Carcinosarcomas: tumors in transition? Histol Histopathol 2015; 30:673.. *Arend R, Doneza JA, Wright JD. Uterine carcinosarcoma ... the incidence of carcinosarcoma is approximately 1 to 4 per 100,000 women [5]. Carcinosarcomas occur in older women; the median ... Uterine carcinosarcomas are rare tumors that account for less than 5 percent of all uterine malignancies [4]. As an example, in ...
Au JT, Sugiyama G, Wang H, Nicastri A, Lee D, Ko W, Tak V (2010). "Carcinosarcoma of the oesophagus - a rare mixed type of ... Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/ ... Carcinosarcoma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material from ... Shim HJ, Hong YK, Kim SJ, Choi YJ, Kang JG (2010). "Carcinosarcoma on ascending colon found by bowel perforation: a case report ...
4 patients with carcinosarcoma experience fatigue, depressed mood, pain, anxious mood, and insomnia. ... Find the most comprehensive real-world symptom and treatment data on carcinosarcoma at PatientsLikeMe. ... What is carcinosarcoma?. Carcinosarcoma is a type of mixed malignant tumor that has elements of carcinoma (cancer of skin and ... 0 carcinosarcoma patients report moderate depressed mood (0%). * 1 a carcinosarcoma patient reports mild depressed mood (100%) ...
... carcinosarcoma) is one form. The other 2 forms are carcinoma ex pleomorphic adenoma and metastasizing benign pleomorphic ... What is the prevalence of true malignant mixed tumor (carcinosarcoma)?. What causes true malignant mixed tumor (carcinosarcoma ... Carcinosarcoma of the salivary glands was first described by Kirklin et al in 1951. [1] The term true malignant mixed tumor in ... Carcinosarcoma is an extremely rare and aggressive entity. [3] It accounts for only 0.04-0.16% of all salivary gland tumors. In ...
Also have uterine carcinosarcoma (MMMT) cancer, NED now. If you have any concerns about the treatment plan your doctors have ... uterine carcinosarcoma. EZLiving, thank you ..it is uterine carsinosarcoma, and they said stage one since they got all they ... Given the aggressive nature of uterine carcinosarcoma, I agreed with my doctors to treat this cancer with both chemo and ... I was diagnosed with uterine carcinosarcoma (MMMT) cancer in November, 2016 and staged as IIIB Grade 3 following surgery in ...
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old ... Carcinosarcoma / chemistry, pathology*, surgery. Cell Transformation, Neoplastic. Esophageal Neoplasms / chemistry, pathology ... We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old ...
Carcinosarcomas of the urinary tract are exceedingly rare. We report a unique case of a carcinosarcoma of the ureter with a ... In this study, we present a case of parotid gland de novo carcinosarcoma. Salivary gland carcinosarcoma (or true malignant ... Wistar rats with Walker-256 carcinosarcoma (a model of mammary gland carcinosarcoma) received Toc-6-Ac, magnetic nanoparticles ... in uterine carcinosarcoma. Patients with histologically confirmed uterine carcinosarcoma were enrolled. Abdominal and pelvic ...
Carcinosarcomas are very rare malignant tumors showing both mesenchymal and epithelial differentiation. They most commonly ... CARCINOSARCOMA OF THE SYGMOID COLON WITH MICROPAPILLARY PATTERN: A CASE REPORT. Zoran Jukić Monika Ulamec Hrvoje Čupić Petar ... Carcinosarcomas are very rare malignant tumors showing both mesenchymal and epithelial differentiation. They most commonly ... To the best of our knowledge, this is the first case of carcinosarcoma of the colon showing micropapillary features and ...
... undifferentiated carcinomas or carcino-sarcomas. Carcino-sarcomas are rare malignant tumours that originate from both the ... In humans, carcinosarcomas of the thyroid gland are a well-recognised tumour histotype and are associated with a poor prognosis ... Cooper, K. & Baker, E.M., 1989, Thyroid carcinosarcoma. A case report, South African Journal of Surgery 27, 192-193. [ Links ... The canine thyroid carcino-sarcoma in this report showed similar biological behaviour and was also associated with a poor ...
Grote J., Süsskind R., Vaupel P. (1978) Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their ... Oxygen Diffusion Constants D and K of Tumor Tissue (DS-Carcinosarcoma) and Their Temperature Dependence. ...
I am a 62-year old woman who was treated for carcinosarcoma in a Fallopian tube, and I live outside of Philadelphia, PA.. On ... Fallopian tube carcinosarcoma. Please read, and agree to, the Agreement Announcement prior to posting your personal story. ... The cancer was carcinosarcoma and highly aggressive. The pathologist thought it had been a mistake, consulted with him about ... Fallopian tube carcinosarcoma. by Silverstreak » Wed Mar 20, 2013 11:05 am ...
carcino sarcoma stage 3c. I too was diagnosed with carcino sarcoma stage 3c. You give me much hope. I am very positive that I ... uterine carcinosarcoma. Hi. just to let you know that I was diagnosed with this type of cancer last year- and what a total ... 47 Yrs Old Stage III-C Uterine Carcino Sarcoma. It was July 2011 and I was 47 years old when I found I had stage III-C Uterine ... Carcinosarcoma - uterus/pelvic region. My mom was diagnosed in late Sept. 2009. She did chemo, which worked for a while, but ...
I am a 62-year old woman who was treated for carcinosarcoma in a Fallopian tube, and I live outside of Philadelphia, PA.. On ... The cancer was carcinosarcoma and highly aggressive. The pathologist thought it had been a mistake, consulted with him about ... Fallopian tube carcinosarcoma. http://www.rare-cancer.org/forum/viewtopic.php?f=143&t=4447 ...
Gastric carcinosarcoma is very rare, and there is no standard chemotherapy regimen. We report a case of a 61-year-old woman ... She was diagnosed as carcinosarcoma of the stomach with distant metastases and underwent chemotherapy with S1-cisplatin. ... with gastric carcinosarcoma associated with the liver and lymph node metastases. She underwent distal gastrectomy due to ...
Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1... ... Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or ... Carcinosarcoma of the esophagus: a twenty-case study. Jpn. J. Clin. Oncol. 1990;20 (1): 99-106. Jpn. J. Clin. Oncol. (abstract) ... Carcinosarcoma of the salivary gland on CT. AJNR Am J Neuroradiol. 1995;16 (8): 1733-5. AJNR Am J Neuroradiol (abstract) - ...
Primary Carcinosarcoma and Sarcomatoid Carcinoma of the Liver: Clinical features, Surgical treatment, and Prognosis. Jiong Lu, ... Background and Aim: Primary carcinosarcoma (CS) and sarcomatoid carcinoma (SC) of the liver are extremely rare malignancies ...
Relapsed or Metastatic Uterine Leiomyosarcomas or Carcinosarcomas Drug: Pazopanib plus Gemcitabine Drug: Pazopanib Phase 2 ... Carcinosarcoma. Mixed Tumor, Mullerian. Neoplasms, Muscle Tissue. Neoplasms, Connective and Soft Tissue. Neoplasms by ... Arm B: Pazopanib 800 mg orally once daily Patients with uterine carcinosarcomas will be treated according to Arm A. ... Arm B (control arm / monotherapy arm): Pazopanib 800 mg orally once daily Patients with uterine carcinosarcomas will be treated ...
Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ... Abstract 5131: Establishment of uterine carcinosarcoma primary cell lines for chemosensitivity testing and evaluation of ...
Objective: Uterine carcinosarcoma (UCS) is an aggressive malignancy, making up less than 5% of uterine cancers. Pharmacologic ... Abstract 2359: Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells ... Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells [abstract]. In ... Abstract 2359: Inhibition of the ATR kinase enhances therapeutic efficacy of cisplatin in ATM low uterine carcinosarcoma cells ...
  • Rauh-Hain JA, Growdon WB, Rodriguez N et al (2011) Carcinosarcoma of the ovary: a case-control study. (springer.com)
  • George EM, Herzog TJ, Neugut AI et al (2013) Carcinosarcoma of the ovary: natural history, patterns of treatment, and outcome. (springer.com)
  • Rauh-Hain JA, Diver EJ, Clemmer JT et al (2013) Carcinosarcoma of the ovary compared to papillary serous ovarian carcinoma: a SEER analysis. (springer.com)
  • to "Carcinosarcoma of the Ovary. (nytimes.com)
  • Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. (wikipedia.org)
  • In the major salivary glands, most reported cases of carcinosarcoma (65%) occurred in the parotid gland. (medscape.com)
  • The carcinomatous component of a carcinosarcoma of the parotid gland. (medscape.com)
  • To the authors' knowledge, de Nova parotid gland carcinosarcoma has been described only a few times in the literature. (clinmedjournals.org)
  • We evaluated the expression of human trophoblastic cell-surface marker (Trop-2) and the potential of hRS7 - a humanized monoclonal anti-Trop-2 antibody - as a therapeutic strategy against treatment-refractory human uterine (UMMT) and ovarian (OMMT) carcinosarcoma cell lines. (biomedcentral.com)
  • These findings suggested that the pancreatic carcinosarcoma could be of monoclonal origin, and that the sarcomatous component might have arisen from metaplastic transformation of the carcinomatous component. (elsevier.com)
  • Carcinosarcoma are mostly of monoclonal origin with the carcinomatous component being the driving force. (worldwidescience.org)
  • The typical features of carcinosarcoma are reviewed below. (uptodate.com)
  • We present a case of a 66-year-old male patient with characteristic features of carcinosarcoma, who was successfully treated by wide local excision and subsequent radiation therapy. (bvsalud.org)
  • She was diagnosed as carcinosarcoma of the stomach with distant metastases and underwent chemotherapy with S1-cisplatin. (ovid.com)
  • An important gene associated with Vaginal Carcinosarcoma is ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Apoptosis Pathway . (malacards.org)
  • This is the first case of primary vaginal carcinosarcoma in which the epithelial and sarcomatous components were clearly identified histologically and immunohistochemically. (elsevier.com)
  • a) Histologic section of prostatic carcinosarcoma with characteristic findings. (hindawi.com)
  • Histologic section of prostatic carcinosarcoma with lymphovascular and perineural invasion. (hindawi.com)
  • Salas G et al (2002) Lung carcinosarcoma in a dog: gross and microscopic examination. (vetbook.org)
  • The biopsy showed a uniform, spindle shape with focal pleomorphism which was suggestive of lung carcinosarcoma. (biomedcentral.com)
  • The description of lung carcinosarcoma was developed in the early 20th century. (biomedcentral.com)
  • Koss MN, Hochholzer L, et al: Carcinosarcoma of the lung. (biomedcentral.com)
  • Jenkins BJ, et al: Carcinosarcoma of the lung. (biomedcentral.com)
  • T. Aramendi, M.J. Fernandez-Acenero and M.C. Villanueva: "Carcinosarcoma of the colon report of a rare tumour", Path. (edu.pl)
  • Carcinosarcoma of the colon is a rare tumour with both epithelial and sarcomatous components. (biomedcentral.com)
  • Among the many features, including pleomorphic oncocytoid epithelial components, necrotic background, and mitoses, recognizing the singly scattered atypical spindle cells is most essential in carcinosarcoma. (bvsalud.org)
  • In the gastrointestinal tract, carcinosarcoma arises predominantly in the oesophagus, in the stomach and in the biliary tract [ 2 ], whereas carcinosarcoma of the large intestine has been reported only rarely. (biomedcentral.com)
  • Biopsy of his prostate indicated that the patient had prostatic adenocarcinoma, but histopathology after prostatectomy revealed carcinosarcoma. (hindawi.com)
  • Thyroid carcinosarcoma, a rare and aggressive histotype: a case report. (radiopaedia.org)
  • Grubor B & Haynes JS (2005) Thyroid carcinosarcoma in a dog. (vetbook.org)
  • Gastric carcinosarcoma is very rare, and there is no standard chemotherapy regimen. (ovid.com)
  • Shylasree TS, Bryant A, Athavale R (2013) Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma. (springer.com)