Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Cell Line, Tumor: A cell line derived from cultured tumor cells.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Breast Neoplasms: Tumors or cancer of the human BREAST.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Carcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Mouth Neoplasms: Tumors or cancer of the MOUTH.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Stomach Neoplasms: Tumors or cancer of the STOMACH.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)DNA, Neoplasm: DNA present in neoplastic tissue.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Tongue Neoplasms: Tumors or cancer of the TONGUE.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Time Factors: Elements of limited time intervals, contributing to particular results or situations.RNA, Neoplasm: RNA present in neoplastic tissue.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Transplantation, Heterologous: Transplantation between animals of different species.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Chemoembolization, Therapeutic: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Rectal Neoplasms: Tumors or cancer of the RECTUM.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Urothelium: The epithelial lining of the URINARY TRACT.Vulvar Neoplasms: Tumors or cancer of the VULVA.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Carcinoma, Giant Cell: An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Niacinamide: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Cell Line: Established cell cultures that have the potential to propagate indefinitely.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Benzenesulfonates: Organic salts and esters of benzenesulfonic acid.Ureteral Neoplasms: Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Mice, Inbred BALB CUp-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Nephrectomy: Excision of kidney.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Adenoma, Oxyphilic: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Adenocarcinoma, Scirrhous: An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)Eyelid Neoplasms: Tumors of cancer of the EYELIDS.Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Neoplasms, Squamous Cell: Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.Carcinoma, Skin Appendage: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Polymorphism, Single-Stranded Conformational: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.Pharyngeal Neoplasms: Tumors or cancer of the PHARYNX.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Verrucous carcinoma of the female breast. (1/43)

Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions present most commonly on the sole of the foot. We report a unique case occurring in the female breast.  (+info)

Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions. (2/43)

Nonmalignant tobacco-associated lesions of the oral cavity were discussed in the first part of this two-part article. Here, we describe malignant lesions associated with tobacco use, basic biopsy principles for such lesions and intervention strategies that dental professionals may use to reduce the chances of their patients developing precancerous lesions or primary malignancies.  (+info)

Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. (3/43)

BACKGROUND: Understanding the molecular mechanisms of metastasis is critical with respect to oral tumorigenesis. The focal adhesion kinase (FAK) is an intracellular tyrosine kinase associated with the regulation of cell growth, migration, and survival. The purpose of the current study was to determine whether elevated FAK expression in oral malignancies was associated with increased invasiveness and oral carcinoma. METHODS: Immunohistochemical analysis was used to assess levels of FAK expression in archived oral carcinoma tissue samples. Invasion assays after transfections were used to assess the effect of increased FAK expression on invasive potential of oral tumor cells. RESULTS: The human oral carcinoma cell line SCC25 was significantly more invasive (P < 0.05) and expressed higher levels of FAK compared with the less invasive human oral carcinoma cell line SCC15. FAK expression was 3.0-fold higher in the SCC15 cell line and 5.0-fold higher in the SCC25 cell line compared with normal epithelial cells. In the highly invasive SCC25 cell line, FAK expression was 1.5-fold higher compared with the less invasive SCC15 cell line. FAK immunostaining in oral tumors was significantly more intense compared with the immunostaining in surrounding normal epithelium or chronic mucositis. Overexpression of FAK in low-invading SCC15 cells resulted in a 4.5-fold increase in the rate of invasion compared with untransfected or neotransfected control SCC15 cell lines and a nearly 1.5-fold greater rate compared with the highly invasive untransfected SCC25 cell line. CONCLUSIONS: The current results suggest that enhanced expression of FAK in oral carcinoma cells may lead to a selective growth advantage and increased invasive potential of the primary oral tumor.  (+info)

Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma. (4/43)

PURPOSE: Oral verrucous carcinoma (VC) has been traditionally treated with surgery or radiation with frequent recurrences and significant morbidity. We describe rapid and dramatic response to oral capecitabine in two patients with advanced refractory VC. EXPERIMENTAL DESIGN: VC is a rare tumor of the oral cavity. It does not metastasize but over time causes morbidity and mortality through local invasion. Radiation and surgery have been the main treatment modalities but are plagued by mutilating effects, recurrences, and possibly malignant degeneration in some cases. To date, no effective chemotherapy regimens have been described in the international literature. The clinical records of two elderly females with extensive oral VC are described. Both patients were prescribed one cycle of capecitabine, 1,000 mg bid for 14 days. Response was documented by photography in one patient. Immunohistochemical evaluation of three 5-fluorouracil metabolizing enzymes on pretreatment biopsies from both patients was also performed. A review of the literature with emphasis on treatment of oral VC is presented in view of our findings. RESULTS: Examination of the oral cavity before treatment revealed extensive involvement with an evenly spreading, exophytic, warty, whitish lesion in both patients. Microscopic examination of H&E-stained slides from biopsies of these lesions confirmed the clinical suspicion of VC. Both patients underwent treatment with oral capecitabine for one cycle (2 weeks on/1 week off) at a reduced dose of 1000 mg, p.o., bid. Both had a dramatic response with near complete resolution of their lesions within 3 weeks of initiating therapy. A durable partial response was documented at 1 year in the first patient and 6 months in the second. Immunohistochemical evaluation of pretreatment biopsies from both patients revealed a high level of expression of thymidine phosphorylase, a key enzyme in the metabolism of capecitabine. CONCLUSIONS: Oral VC is a rare entity with a progressive course over years and limited options in terms of treatment. Preliminary observations in two elderly patients demonstrate that capecitabine, an oral fluoropyrimidine, is well tolerated and may induce rapid, clinically significant response. Although not curative, it may provide a cost-effective alternative for elderly patients with a significant improvement in their quality of life.  (+info)

Invasive cutaneous verruco-cystic squamous cell carcinoma. A pattern commonly present in transplant recipients. (5/43)

To determine whether certain histologic features are more common in cutaneous squamous cell carcinomas (CSCCs) arising in transplant recipients than in others, we assessed several features of CSCCs from 23 patients who had not undergone transplantation and 25 transplant recipients (size, depth of invasion, sun damage, nuclear atypia, keratinization, epidermal inclusion cyst [EIC]-like features, verrucous features [VFs], shape, and mitoses per 10 high-power fields). We analyzed relationships by using chi 2 and t tests and logistic regression analysis. Transplant recipients tended to be younger than control subjects (mean [SD] age, 56.2 [14.3]; 74.1 [10.6], respectively; P < .0001) and less likely to show severe sun damage (P = .0455; chi 2). CSCCs with VFs and EIC-like features were associated strongly with transplantation: odds ratio, 12.57 (95% confidence interval, 1.28-123.47; P = .0162). No other features were associated significantly with transplant status. Posttransplant tumors commonly showed verrucous and EIC-like features mimicking benign conditions. The younger age of these patients, the frequent absence of solar elastosis, and the infrequent occurrence of well-differentiated verruco-cystic CSCC in the nontransplant population suggest a different pathogenesis in the development of these neoplasms. Pathologists should be aware of this pattern, especially when diagnosing small biopsy specimens from transplant recipients.  (+info)

Surgical treatment of oral verrucous carcinoma. (6/43)

BACKGROUND: The aim of this study was to evaluate the outcome of patients with Verrucous carcinoma (VC) of oral cavity treated at the Chung Gung Memory Hospital with respect to the tumor control rates after surgery, the risk of lymph node metastasis and the role of radiation therapy. METHODS: Thirty-eight patients underwent primary treatment for VC of the oral cavity from January 1996 through February 2002. All of the patients had surgery as their primary treatment. In addition, all patients with sufficient details of the therapy and a minimum 1-year follow-up were selected for evaluation of survival and outcomes. RESULTS: In this study, 94.7% of patients were male and most of them had been exposed to betel nuts, cigarettes, and/or alcohol. The most common site was the buccal mucosa (57.9%), followed by the tongue (13.2%). T3 lesions were the most common type (34.2%). Only two patients had palpable cervical adenopathy during the initial evaluation. Twenty-five patients had free flap for reconstruction. The tumor control rate was 100%. At the time of analysis, no patient had suffered from recurrence in primary site or neck area. CONCLUSION: Surgical excision alone was effective for controlling VC, but elective neck dissection was not necessary even in patients in the advanced stages.  (+info)

Verrucous carcinoma of the bladder with koilocytosis unassociated with vesical schistosomiasis. (7/43)

CONTEXT: Verrucous carcinoma of the bladder is a very rare malignant neoplasm, histologically similar to condyloma acuminatum. Usually it shows association with vesical schistosomiasis (bilharziasis). Only 13 cases unrelated to bilharziasis have been reported to date, and none of them reported koilocytosis, a typical finding in human papillomavirus infection. CASE REPORT: We report a case of verrucous carcinoma of the bladder that was unrelated to bilharziasis, with koilocytosis and absence of human papillomavirus. The literature relating to the topic is discussed.  (+info)

Association of laryngeal cancer with previous gastric resection. (8/43)

OBJECTIVE: To investigate the association between gastric surgery and cancer of the larynx. SUMMARY BACKGROUND DATA: Biliary reflux is frequent after gastric surgery and may reach the proximal segment of the esophagus and the larynx. It is possible that duodenal content (consisting in bile acids, trypsin), together with pepsin and acid residues when gastric resection is partial, may cause harmful action on the multistratified epithelium of the larynx. METHODS: A retrospective case-control study on subjects admitted between January 1987 and May 2002 in the same hospital in Rome was carried out. The study included 828 consecutive patients with laryngeal cancer (cases) and 825 controls with acute myocardial infarction. Controls were randomly sampled out of a total of 10,000 and matched with cases for age, sex, and year of admission. Logistic regression models were used to assess the role of gastric resection in determining laryngeal cancer risk while controlling for potential confounding factors. RESULTS: Previous gastrectomy was reported by 8.1% of cases and 1.8% of the controls (P < 0.0001). A 4-fold association emerged between gastric surgery and laryngeal cancer risk (adjusted OR = 4.3, 95% CI: 2.4-7.9). The risk appeared strongly increased 20 years after surgery (OR = 14.8, 95% CI: 3.4-64.6). Heavy alcohol drinking (OR = 2.5, 95% CI: 1.8-3.5), smoking (OR = 4.7, 95% CI: 3.3-6.7), and blue-collar occupation (OR = 4.6, 95% CI: 3.2-6.7) were all independently associated with the risk of laryngeal cancer. CONCLUSIONS: Previous gastric surgery is associated with an increased risk of laryngeal cancer. A periodic laryngeal examination should be considered in long-term follow-up of patients with gastric resection.  (+info)

*Verrucous carcinoma

... (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ... Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis ... National survey of head and neck verrucous carcinoma. Cancer 2001;92:110-20 McDonald JS, Crissman JD, Gluckman JL. Verrucous ... Verrucous carcinoma may occur in various head and neck locations, as well as in the genitalia. The oral cavity is the most ...

*List of verrucous carcinoma subtypes

Several subtypes of verrucous carcinoma have been described. Treatment of verrucous carcinoma with radiation therapy should be ... Verrucous carcinoma is a type of squamous cell carcinoma that may be associated with HPV infection (may be subtypes 16 or 18, ...

*Syringocystadenoma papilliferum

ISBN 0-7216-2921-0. Monticciolo NL, Schmidt JD, Morgan MB (2002). "Verrucous carcinoma arising within syringocystadenoma ...

*Epithelioma cuniculatum

... a type of verrucous carcinoma that may occur on the sole of the foot. List of verrucous carcinoma subtypes James, William; ... Epithelioma cuniculatum (also known as Carcinoma cuniculatum, and Ackerman tumor) is a skin lesion, ...

*Oral florid papillomatosis

This is a type of verrucous carcinoma. Mucous membrane Erythroplakia Proliferative verrucous leukoplakia List of cutaneous ... conditions List of verrucous carcinoma subtypes James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the ...

*Penile cancer

Tis: Carcinoma in situ. Ta: Noninvasive verrucous carcinoma. T1a: Tumor invades subepithelial connective tissue without lymph ... Around 95% of penile cancers are squamous cell carcinomas. Other types of penile cancer such as Merkel cell carcinoma, small ... carcinoma in situ-Bowen's disease, Erythroplasia of Queyrat and bowenoid papulosis (BP)); D. Invasive Carcinoma of the Penis. ... sarcomatoid carcinomas (1%) not otherwise specified (49%) Other types of carcinomas are rare and may include small cell, Merkel ...

*Giant condyloma acuminatum

List of cutaneous conditions List of verrucous carcinoma subtypes Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. ( ... wart-like growth that is a verrucous carcinoma. It is attributed to human papillomavirus. ...

*Papillomatosis cutis carcinoides

Verrucous carcinoma List of cutaneous conditions List of verrucous carcinoma subtypes Rapini, Ronald P.; Bolognia, Jean L.; ... is a cutaneous condition characterized by verrucous skin lesions, and is due to an HPV infection of the skin. ...

*Rudolf Virchow

It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... "Hybrid verrucous carcinoma of the oral cavity: A challenge for the clinician and the pathologist". Oral Oncology Extra. 42 (2 ... First described by Karl Thiersch in the 1860s.) But he made a crucial observation that certain cancers (carcinoma in modern ... They found that the larynx was extensively damaged due to ulcer, and microscopic examination confirmed epidermal carcinoma. Die ...

*Dipping tobacco

There is relatively low risk of transformation of this lesion into mouth cancer (sometimes verrucous carcinoma). Dipping ...

*Leukoplakia

There is a very high risk of dysplasia and transformation to OSCC or to verrucous carcinoma. Erythroleukoplakia (also termed ... Verrucous leukoplakias are usually heavily keratinized and are often seen in elderly people. Some verrucous leukoplakias may ... Proliferative verrucous leukoplakia (PVL) is a recognized high risk subtype of non-homogenous leukoplakia. It is uncommon, and ... Verrucous or nodular areas have a higher risk. Although smoking increases risk of malignant transformation, smoking also causes ...

*International Classification of Diseases for Oncology

NOS M8051/0 Verrucous papilloma M8051/3 Verrucous carcinoma, NOS Condylomatous carcinoma Verrucous squamous cell carcinoma ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... Renal cell carcinoma, spindle cell M8319/3 collecting duct carcinoma (C64.9) Bellini duct carcinoma Renal carcinoma, collecting ... NOS Intraepithelial squamous cell carcinoma M8070/3 Squamous cell carcinoma, NOS Epidermoid carcinoma, NOS Squamous carcinoma ...

*Smokeless tobacco keratosis

... generally squamous cell carcinoma and its variant verrucous carcinoma) is relatively low. Indeed, veruccous carcinoma is ... Snuff dipping is associated more with verrucous keratosis. As well as the white changes of the oral mucosa, there may be ... The differential diagnosis includes other oral white lesions such as Leukoplakia, squamous cell carcinoma, oral candidiasis, ...

*Rectal discharge

... and verrucous carcinoma. Cryotherapy Adenoma is the most common colorectal polyp. Adenomas are not malignant, but rarely ... Anal carcinoma is much less common than colorectal cancer. The most common form is squamous cell carcinoma, followed by ... Because these symptoms are so unspecific, and because symptoms of anal carcinoma may not always be typical, this can lead to ... Jensen, SL; Hagen, K; Shokouh-Amiri, MH; Nielsen, OV (May 1987). "Does an erroneous diagnosis of squamous-cell carcinoma of the ...

*Grover Cleveland

... analysis of the specimen finally confirmed the tumor to be verrucous carcinoma, a low-grade epithelial cancer with a low ... Keen, stated after Cleveland's death that the tumor was a carcinoma. Other suggestions included ameloblastoma or a benign ...

*Larynx

Two related types of cancer of the larynx, namely squamous cell carcinoma and verrucous carcinoma, are strongly associated with ...

*Verrucous

... carcinoma Verrucous lupus erythematosus Proliferative verrucous leukoplakia Verrucous perforating collagenoma ... Verrucous cyst Verrucous vascular malformation Unilateral palmoplantar verrucous nevus. ... Verrucous (appearing like a wart or "verruca") can refer to: ...

*List of histologic stains that aid in diagnosis of cutaneous conditions

... integumentary system List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

*Verruciform xanthoma

... and verrucous carcinoma Surgical excision is the treatment of choice. Verruciform xanthoma is uncommon, with a female:male ... Haustein UF (1984). "[Xanthomatous cells in inflammatory linear verrucous epidermal nevus or nevoid verruciform xanthoma?]". ...

*List of cutaneous neoplasms associated with systemic syndromes

... integumentary system List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

*List of migrating cutaneous conditions

... with cutaneous reactions List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

*List of spiders associated with cutaneous reactions

... with cutaneous reactions List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

*Epidermolytic hyperkeratosis

List of cutaneous conditions List of cutaneous conditions caused by mutations in keratins List of verrucous carcinoma subtypes ...

*Vulvar cancer

A verrucous carcinoma of the vulva is a rare subtype of squamous cell cancer and tends to appear as a slowly growing wart. ... is squamous cell carcinoma, which originates from epidermal squamous cells, the most common type of skin cell. Carcinoma-in- ... Basal cell carcinoma makes up about 1-2% of vulvar cancer. These tend to be slow-growing lesions on the labia majora but can ... Verrucous vulvar cancers tend to have good overall prognoses. Melanoma is the second most common type of vulvar cancer and ...

*Squamous cell carcinoma

Verrucous squamous cell carcinoma (Code 8051/3) Papillary squamous cell carcinoma (Code 8052/3) Squamous cell carcinoma (Code ... Adenoid squamous cell carcinoma Basaloid squamous cell carcinoma Clear-cell squamous cell carcinoma Spindle-cell squamous cell ... Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from ... Three carcinoma in situ are associated with squamous cell carcinoma of the penis: 1) Bowen's disease which presents as ...

*Urethral caruncle

Unilateral palmoplantar verrucous nevus Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume ... Pathologiy studies are necessary to distinguish carcinoma of the urethra from urethral caruncles. Caruncles can grow back in ...
Mucositis Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage III Verrucous Carcinoma of the Larynx Stage III Verrucous Carcinoma of the Oral Cavity Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IVA Squamous Cell ...
Mucositis Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage III Verrucous Carcinoma of the Larynx Stage III Verrucous Carcinoma of the Oral Cavity Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IVA Squamous Cell ...
Maciel, A. P., Tieghi Neto, V., Ikuta, C. R. S., Taveira, L. A. de A., Ponce, J. B., Santos, P. S. da S., & Rubira, C. M. F. (2017). Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. St. Louis. Recuperado de https://doi.org/10.1016/j.oooo.2017.05. ...
Verrucous carcinoma is a variant of squamous cell carcinoma (SCCA). In the head and neck, this uncommon subtype of SCCA is seen most often in the oral cavity or on the vocal cords. Visually, it tends to have an exophytic (outward-growing) and wartlike, irregular surface. This variant of SCCA is typically less aggressive than other squamous cell carcinomas. Local recurrence tends to be the issue more than distant metastasis. Surgery tends to be the most effective treatment, though of course every patients circumstance is individualized and considered in the light of three treatment options: surgery, radiation therapy, and chemotherapy.. ...
PubMed journal article Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case repor were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Journal of the American Academy of Dermatology - Vol. 57 - N° 3 - p. 516-519 - Photodynamic therapy for cutaneous verrucous carcinoma - EM|consulte
Denise Tostes Oliveira, Renato Vieira de Moraes, Jorge Francisco Fiamengui Filho, João Fanton Neto, Gilles Landman, Luiz Paulo Kowalski
Comment:. Sections demonstrate two distinct histologic neoplasms: an inverted papilloma and a coexisting verrucous carcinoma. Microscopically, the inverted papilloma comprises less than 10% of the tumor mass. Inverted papillomas are not infrequently associated with malignant tumors, primarily squamous cell carcinoma, and in some instances malignant transformation in an inverted papilloma to carcinoma may be observed. In this case, there is no transitional zone in the sections examined to suggest that the verrucous carcinoma is arising directly from the inverted papilloma. Although immunoperoxidase stains for human papillomavirus antigens are negative in both components of the tumor mass, inverted papillomas and verrucous carcinomas have been associated with human papillomavirus infection. ...
Diagnostic and Therapeutic Endoscopy is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of diagnostic and therapeutic endoscopy.
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Inclusion Criteria:. Pathologically (histologically) proven diagnosis of squamous cell carcinoma (including variants such as verrucous carcinoma, spindle cell carcinoma, carcinoma not otherwise specified [NOS], etc.) of the head/neck (oral cavity, oropharynx or larynx); note: hypopharynx primaries are excluded. Clinical stage T1, N1-2 or T2-4a, N0-2, M0 including no distant metastases, based upon the following minimum diagnostic workup:. General history and physical examination by a radiation oncologist and/or medical oncologist within 8 weeks prior to registration. Examination by an ear, nose and throat (ENT) or head & neck surgeon, within 8 weeks prior to registration; a laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) is recommended but not required. Chest x-ray (at a minimum) or chest computed tomography (CT) scan (with or without contrast) or CT/positron emission tomography (PET) of chest (with or without contrast) within 8 weeks prior to registration. Gross total ...
Oral cancer accounts for about 3-4% of all cancers. Of all oral cancers, 96% are carcinomas and 4% are sarcomas. The most common type of oral cancer is squamous-cell carcinoma, constituting about 90% of oral malignancies.1 Tobacco smoke contains a number of hydrocarbons that are powerful carcinogens. Tobacco smoke and unburned tobacco, used in chewing or snuff dipping, also contain several potent nitrosamines. These chemicals are all DNA-toxic carcinogens that may play a key role in the initiation and promotion of specific types of cancer such as squamous-cell carcinoma and verrucous carcinoma2 (Figs. 1 and 2). Although the most common intraoral site for carcinoma is the posterior ventrolateral border of the tongue, the floor of the mouth is also frequently affected. Together with the retromolar region, these areas form a horseshoe-shaped zone of increased cancer susceptibility and the location of about 75-85% of all intraoral cancers3 (Fig. 3). Squamous-cell carcinoma of the tongue is the most ...
Cinthia B Drachenberg MD, Remy Blanchaert MD DDS, Olga B Ioffe MD, Robert A Ord MD DDS, John C Papadimitriou MD PhD. In verrucous carcinoma (VC) the apoptotic index consistently ranged from 0.1 to 1%, Ki-67 positive nuclei were confined to the basal epithelial layer, bcl-2 was expressed only in the cytoplasm of few scattered cells and p53 mutations were present in 50% of the lesions. In squamous cell carcinoma the apoptotic index ranged from 3 to 8 %, K-67 positive nuclei were randomly distributed, bcl-2 cytoplasmic and nuclear expression was more widespread and higher than in VC. p53 positive nuclei were identified in 62.5% of the lesions. ,,,. ...
HSV infection in human immunodeficiency virus (HIV)-infected patients and other immunodeficiency states with T-cell defects is common and often presents with more severe and chronic disease. Recurrent outbreaks are more painful, more widespread, last longer, are poorly responsive to therapy, and have a higher risk of viremic dissemination. In addition, genital HSV infections in immunocompromised patients can have atypical presentations. Verrucous and exophytic nodules resembling condyloma acuminatum and verrucous carcinoma have been described. Chronic, nonhealing, painful ulcers occur, particularly in the perianal region. Infection with genital HSV confers an increased risk of acquiring and transmitting HIV. Others at risk for this include marrow and solid organ transplant patients and patients with lymphoma and leukemia ...
The aim of this study was to analyze proliferative verrucous leukoplakia (PVL) and oral squamous cell carcinoma (OSCC) for the possible presence of Epstein-Barr virus (EBV). We studied three groups: Sub-Group 1 was composed of 10 patients with PVL, (6 of whom had developed OSCC); Sub-Group 2 comprised 5 patients with OSCC but no preceding PVL; and Sub-Group 3 were 5 controls with clinically normal oral mucosa. Oral biopsies from all cases were examined for Epstein-Barr virus (EBV) by nested PCR. EBV was detected in 60% of Sub-Group 1 patients (PVL ) and in 40% of Sub-Group 2 (OSCC), but in 0% of SubGroup 3 (controls ...
Penile Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated...
Penile Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated...
Penile carcinoma (PeCa) represents an important public health problem in poor and developing countries. Despite its unpredictable behavior and aggressive treatment, there have only been a few reports regarding its molecular data, especially epigenetic mechanisms. The functional diversity in different cell types is acquired by chromatin modifications, which are established by epigenetic regulatory mechanisms involving DNA methylation, histone acetylation, and miRNAs. Recent evidence indicates that the dysregulation in these processes can result in the development of several diseases, including cancer. Epigenetic alterations, such as the methylation of CpGs islands, may reveal candidates for the development of specific markers for cancer detection, diagnosis and prognosis. There are a few reports on the epigenetic alterations in PeCa, and most of these studies have only focused on alterations in specific genes in a limited number of cases. This review aims to provide an overview of the current knowledge
This is a genetic test used to diagnose some underlying malignant disorder. Your physician might order some additional tests depending on your presentation
Penis 02: penile carcinoma, illustration relating to dogs including description, information, related content and more. WhiteRAS. Canis ISSN: 2398-2942. Related terms: . All information is peer reviewed.
Listen to Argon OVC, Mark Loop Radio, free! Stream songs by Argon OVC, Mark Loop & similar artists plus get the latest info on Argon OVC, Mark Loop!
Bowens disease of the skin. This is an early form of skin cancer that may develop as a result of long-term exposure to the sun. It is easily curable as it does not metastasise (spread) and it stays within the top layer of the skin (the epidermis), so is easily excised. There is a small chance that a Bowens disease lesion will become a malignant (cancerous) squamous cell carcinoma, so early treatment is recommended. - Stock Image C021/3552
This page includes the following topics and synonyms: Penile Carcinoma in Situ, Penile Cancer in Situ, Penile Erythroplasia of Queyrat, Bowen Disease of the Penis, Carcinoma in Situ of Penis.
0031]In an embodiment of the present invention, the jacket 30 is added over the OVC. The OVC is carried in a pallet in the usual manner. FIG. 2 shows an OVC 14 housing cooled equipment (not shown), mounted within a pallet 26, typically an open-sided metal frame, by resilient mounting blocks 28 of rubber or a similarly resilient polymer. The pallet protects the OVC and the cooled equipment from mechanical damage, while the resilient mounting blocks protect the OVC and the cooled equipment from mechanical shocks. Jacket 30 may have holes arranged to allow mounting blocks 28 to pass therethrough, so as not to interfere with the mechanical mounting of the OVC. In such an arrangement, the jacket serves to keep the OVC cool during transport, and may be discarded on arrival at the destination. The pallet may be returned to the supplier for re-use, or may be recycled if this is considered economically viable, or desirable for other reasons. Similarly, the jacket could be returned to the supplier for ...
Visit OVC Smith Lane Animal Hospital in Guelph! Your local OVC Smith Lane Animal Hospital that will care and look after your pet family member. Contact us at 519-840-0100 to set up an appointment!
The adult trachea measures approximately 12 cm but varies anywhere from 10 to 13 cm depending on height and sex. As there is some variability in the length, the anterior portion of the trachea is not subject to tremendous change, for the most part is composed of cartilage, and is C-shaped. The rings maybe complete or bifid. The posterior part of the trachea is also called the membranous portion and is the part of the airway that moves with breathing (Figure 37-1A). ...
Place posted the fastest 5K time in the OVC on Saturday at the Evansville Invitational, running the course in school record time of 17:34.54, which was good enough for third place out of 188 runners and just three seconds behind the individual winner ...
The authors describe the results on EGFR molecular alterations of 29 Brazilian patients with penile carcinoma (PC). DNA extracted from frozen tumor tissue of all patients was submitted to direct sequencing of the four exons (18-21) responsible for the EGFR tyrosine-kinase activity. Corroborating the data by Di Lorenzo et al. published in Expert Opin Ther Targets, none of the sequenced tumor samples showed relevant alterations in the four studied exons of the EGFR gene. © Informa UK, Ltd ...
Bowens disease is a type of skin disorder that is closely linked to skin cancer, often affecting the outermost skin layer called epidermis. This form of skin disorder is slow growing with higher chances of favorable prognosis. People suffering from this condition notice a red and flaky skin patch on the lower part of their legs which they sometimes thought of as psoriasis.. Bowens disease is also referred to squamous cell carcinoma in situ, so individuals who have it should start treatment immediately as the condition may aggravate to cancer (squamous cell carcinoma). There is variety of ways to treat Bowens disease, all of which are often successful.. ...
TY - JOUR. T1 - The association between fecal hemoglobin concentration and oral potentially malignant disorders. AU - Yen, Amy Ming Fang. AU - Wang, Sen Te. AU - Feng, Sheng Wei. AU - Lin, Che Tong. AU - Chen, Sam Li Sheng. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objectives: The present study was to investigate the association between fecal hemoglobin (f-Hb) concentration and oral cancer and its precursor, oral potentially malignant disorders (OPMD). Methods: We used a population-based longitudinal cohort study data based on both Taiwanese nationwide oral and colorectal cancer screening programs implemented between 2004 and 2009. The total of 235,234 smokers and/or betel-quid chewers aged 50 to 69 years free of oral cancer and OPMD at entry were followed up over time to quantify the association between baseline f-Hb concentration on newly diagnosed oral cancer and OPMD. Results: The risk of OPMD increased with baseline f-Hb in a dose manner, yielding a statistically significant elevated risk of ...
Huge locally invasive mass beneath the foreskin obstructing the urethra (arrow) causing it to be distended with urine. Multiple enlarged inguinal lymph nodes. ...
Key Points *Common skin cancer, forming in the cells of the outer skin layer *Most cases caused by sun exposure, but may be the result of other...
In spite of tremendous progress in the field of molecular biology there is yet no single marker that reliably predicts malignant transformation of a potentially malignant disorder of the oral mucosa. Therefore, it is recommended to excise or laser any oral of oropharyngeal leukoplakia/erythroplakia, if feasible, irrespective of the presence or absence of dysplasia. However, it is actually unknown whether such removal truly prevents the possible development of a squamous cell carcinoma. Therefore, lifelong follow-up is recommended at intervals of no more than 6 months ...
Visit OVC Smith Lane Animal Hospital in Guelph! Your local OVC Smith Lane Animal Hospital that will care and look after your pet family member. Contact us at 519-840-0100 to set up an appointment!
Background Oral squamous cell carcinoma (OSCC) is one of the most dangerous cancers in the body, producing serious complications with individual behaviors. Many different pathogenetic factors are...
Oral squamous cell carcinoma: like owner, like cat Links between lifestyle and oral cancers in cats Source: Laura Snyder The Veterinary Journal vol
Pris: 659 kr. Häftad, 2013. Skickas inom 10-15 vardagar. Köp Incidence of Second Primary in Oral Squamous Cell Carcinoma av Baliga Mohan, Shenoy Nandita, Bhambar Rohan på Bokus.com.
Archer appeared and started 14 games, maintaining a 4.04 ERA (10th in the OVC)… struck out a season-high 13 batters in his last start of the season against Austin Peay… totaled 76 strikeouts for the year, ranking fifth in the OVC… threw a complete game against Murray State, giving up just four hits, one earned run, and one walk while striking out seven… tied for third in the conference with 6.3 innings pitched per game… allowed opponents to hit just .264, ranking ninth in the OVC… named OVC Pitcher of the Week for Apr. 2 and May 21.. 2011 (SOPHOMORE): ...
Thirty one patients with carcinoma of penis were studied retrospectively at Kenyatta National Hospital, Nairobi, over a 20-year period (1971-1990). The majority of patients presented late with symptomatology of over one year duration. 88% of patients with carcinoma were uncircumcised, while the three (12%) patients who were circumcised but developed carcinoma were all circumcised late in adolescence and adulthood, confirming that late circumcision may not protect one from developing penile carcinoma as reported in literature. These findings also indicate that carcinoma of penis may be rare in this locality but is still common among the uncircumcised African tribes ...
Out of all the decisions Sarah and I made before our girls were born, naming them was one of the hardest. But with Bowen, every decision has been harder than
One of the few areas where I may not be in entire agreement with my party is on the above subject and the issue of licensing generally (I have not seen evidence of 24 hour drinking in Feltham & Heston or things being any worse than before the legislation, though I do accept that the…
Current organotypic models of dysplasia and oral squamous cell carcinoma (OSCC) lack the complexity that mimics in vivo tissue. Here we describe a three-dimensional in vitro model of the oral epithelium that replicates tumour progression from dysplas
Overall, the dermoscopic criteria most frequently observed in Bowens disease (BD) were scales, glomerular vessels, yellow crusts, focal hemorrhage, focal/multifocal hypopigmentation, linear irregular vessels, clusters of brown structureless areas, periphery radial streaks, and double-edge sign.". Read Full Blog on Dermcast.tv. ...
The Ontario Veterinary College (OVC) is dedicated to the advancement of veterinary and comparative medicine through teaching, research and service. As the oldest veterinary college in Canada and the United States, OVC has been educating veterinarians since 1862. Our Colleges alumni span the globe, working in areas as diverse as clinical practice, food safety and ecosystem health.. ...
Crucial approaches to diagnostics and anaemia treatment in pregnant women with heart failure at the extragenital pathology clinic
Crucial approaches to diagnostics and anaemia treatment in pregnant women with heart failure at the extragenital pathology clinic
Erythroplasia of Queyrat is a carcinoma in situ of the mucosa and the transitional epithelia. It resembles Bowens disease and therefore the terms are frequently equated.

Photodynamic therapy for cutaneous verrucous carcinoma - EM|consultePhotodynamic therapy for cutaneous verrucous carcinoma - EM|consulte

57 - N° 3 - p. 516-519 - Photodynamic therapy for cutaneous verrucous carcinoma - EM,consulte ... Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm ... An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 ... The use of methyl-aminolevulinate-photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far ...
more infohttps://www.em-consulte.com/en/article/439018

PRIME PubMed | Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case reporPRIME PubMed | Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case repor

PubMed journal article Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case repor were found in ... Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. In most cases, verrucous carcinoma ... Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. In most cases, verrucous carcinoma ... These features are consistent with the growth pattern of verrucous carcinoma. CONCLUSIONS: Verrucous carcinoma can manifest as ...
more infohttps://www.unboundmedicine.com/medline/citation/27036299/Endoscopic_submucosal_dissection_for_an_atypical_small_verrucous_carcinoma:_a_case_report_

Verrucous carcinoma - LaryngopediaVerrucous carcinoma - Laryngopedia

Verrucous carcinoma Verrucous carcinoma. Verrucous carcinoma is a variant of squamous cell carcinoma (SCCA). In the head and ... Verrucous carcinoma (1 of 5) Verrucous carcinoma, left vocal cord, persistent after radiotherapy elsewhere, in a patient unable ... Verrucous carcinoma, several weeks after laser treatment (5 of 5) During voicing. Arytenoid moves, but much of membranous vocal ... Verrucous carcinoma, after laser treatment (3 of 5) After several Thulium Laser ablations, using topical and injected local ...
more infohttps://laryngopedia.com/verrucous-carcinoma/

BDPI USP - Detalhe do registro: Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinomaBDPI USP - Detalhe do registro: Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma

Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma (2017). *Authors: *Maciel, Aloizio Premoli - ... Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma [Internet]. Oral Surgery, Oral Medicine, Oral ... Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma [Internet]. Oral Surgery, Oral Medicine, Oral ... Verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma. Oral Surgery, Oral Medicine, Oral Pathology and ...
more infohttps://repositorio.usp.br/item/002856076

Signet ring cell carcinoma - wikidocSignet ring cell carcinoma - wikidoc

Papilloma/carcinoma (8010-8139). Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - ... Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor ... Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous ... Signet ring cell carcinoma is an epilethial malignancy characterized by the histologic appearance of signet ring cells. ...
more infohttp://es.wikidoc.org/index.php/Signet_ring_cell_carcinoma

Verrucous carcinoma - WikipediaVerrucous carcinoma - Wikipedia

Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ... Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis ... National survey of head and neck verrucous carcinoma. Cancer 2001;92:110-20 McDonald JS, Crissman JD, Gluckman JL. Verrucous ... Verrucous carcinoma may occur in various head and neck locations, as well as in the genitalia. The oral cavity is the most ...
more infohttps://en.wikipedia.org/wiki/Verrucous_carcinoma

American Urological Association - Verrucous CarcinomaAmerican Urological Association - Verrucous Carcinoma

Home Education AUAUniversity Education Products & Resources Pathology for Urologists Penis Carcinomas Verrucous Carcinoma ... Radiation should be avoided as it may cause the verrucous carcinoma to dedifferentiate into a highly aggressive spindle cell ... Clinical: Rare, accounts ~4% of penile carcinoma.. *Gross: Exophytic tumor with papillary or spiky surface affecting the glans ... Well-differentiated squamous cell carcinoma with broad pushing borders rather than the finger-like infiltrative borders of a ...
more infohttp://auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/penis/carcinomas/verrucous-carcinoma

Cervix - Verrucous carcinomaCervix - Verrucous carcinoma

Warty / condylomatous carcinoma: prominent cytoplasmic halos around tumor cells End of Cervix > Carcinoma > Verrucous carcinoma ... Carcinoma. Verrucous carcinoma. Reviewer: Dr. Branko Perunovic (see Reviewers page). Revised: 13 June 2016, last major update ... Squamous cell carcinoma with papillary growth pattern: usually has finger-like invasive tongues, marked nuclear atypia * ... One paper claims that HPV+ cases are better classified as SIL, giant condyloma or invasive squamous cell carcinoma (Can J Surg ...
more infohttp://www.pathologyoutlines.com/topic/cervixverrucous.html

List of verrucous carcinoma subtypes - WikipediaList of verrucous carcinoma subtypes - Wikipedia

Several subtypes of verrucous carcinoma have been described. Treatment of verrucous carcinoma with radiation therapy should be ... Verrucous carcinoma is a type of squamous cell carcinoma that may be associated with HPV infection (may be subtypes 16 or 18, ...
more infohttps://en.wikipedia.org/wiki/List_of_verrucous_carcinoma_subtypes

Oral Verrucous Carcinoma Mimicking a Chronic Candidiasis: A Case ReportOral Verrucous Carcinoma Mimicking a Chronic Candidiasis: A Case Report

R. H. Spiro, "Verrucous carcinoma, then and now," American Journal of Surgery, vol. 176, no. 5, pp. 393-397, 1998. View at ... L. V. Ackerman, "Verrucous carcinoma of the oral cavity," Surgery, vol. 23, no. 4, pp. 670-678, 1948. View at Google Scholar · ... Oral Verrucous Carcinoma Mimicking a Chronic Candidiasis: A Case Report. Natália Galvão Garcia,1 Denise Tostes Oliveira,1 João ... J. M. McCoy and C. A. Waldron, "Verrucous carcinoma of the oral cavity. A review of forty-nine cases," Oral Surgery Oral ...
more infohttps://www.hindawi.com/journals/crionm/2012/190272/ref/

Recurrent Verrucous Carcinoma of the Larynx - DrugBankRecurrent Verrucous Carcinoma of the Larynx - DrugBank

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
more infohttps://www.drugbank.ca/indications/DBCOND0029506

Verrucous Carcinoma of the Larynx Presenting as a Hairy Whitish TumorVerrucous Carcinoma of the Larynx Presenting as a Hairy Whitish Tumor

... Masahiro Kawaida,1 Hiroyuki Fukuda,2 and Naoyuki Kohno3 ... A patient was encountered with verrucous carcinoma of the larynx that presented as a hairy whitish tumor. There was a ...
more infohttps://www.hindawi.com/journals/dte/1997/864231/abs/

Verrucous carcinoma of the tracheobronchial tree: an underdiagnosed entity? | European Respiratory SocietyVerrucous carcinoma of the tracheobronchial tree: an underdiagnosed entity? | European Respiratory Society

Verrucous carcinomas, first described by Ackermann [1] in 1948, are rare, well-differentiated squamous cell carcinomas in the ... Verrucous carcinomas are rare, well-differentiated squamous cell carcinomas that in most cases seem to be confined to the basal ... While there are a number of reports on verrucous carcinomas of the larynx, we could not find any reports about verrucous ... the possibility of their being verrucous carcinomas should be borne in mind. We believe that a larger number of verrucous ...
more infohttp://erj.ersjournals.com/content/43/4/1198

Verrucous Carcinoma Global Clinical Trials Review, H2, 2016Verrucous Carcinoma Global Clinical Trials Review, H2, 2016

Verrucous Carcinoma Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2016* *Proportion of Verrucous Carcinoma to ... Verrucous Carcinoma Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2016* *Proportion of Verrucous Carcinoma to ... Verrucous Carcinoma Therapeutics, Global, Clinical Trials and Average Enrollment by Top Countries, 2016* *Verrucous Carcinoma ... Proportion of Verrucous Carcinoma to Oncology Clinical Trials, G7 Countries (%), 2016* *Verrucous Carcinoma Therapeutics, G7 ...
more infohttps://www.giiresearch.com/report/gd329833-verrucous-carcinoma-global-clinical-trials-review.html

Verrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein | Springer for Research & DevelopmentVerrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein | Springer for Research & Development

Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and... ... Verrucous carcinoma and giant condyloma of Buschke and Löwenstein are identical lesions. ... Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and Löwenstein. It is a ... 2017) Verrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein. In: Carneiro F., Chaves P., Ensari A. (eds) Pathology of ...
more infohttps://rd.springer.com/referenceworkentry/10.1007/978-3-319-40560-5_2864

Frontiers | Verrucous Carcinoma of the Vulva: A Case Report and Review of the Literature | SurgeryFrontiers | Verrucous Carcinoma of the Vulva: A Case Report and Review of the Literature | Surgery

... this lesion is a distinct and particular entity in the vulva carcinoma classification and its scalability is uncertain and ... this lesion is a distinct and particular entity in the vulva carcinoma classification and its scalability is uncertain and ... Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, ... Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, ...
more infohttps://www.frontiersin.org/articles/10.3389/fsurg.2016.00008/full

Recurrent Verrucous Carcinoma of the Larynx Recruiting Phase 1 Trials for Paclitaxel (DB01229) - DrugBankRecurrent Verrucous Carcinoma of the Larynx Recruiting Phase 1 Trials for Paclitaxel (DB01229) - DrugBank

Recurrent Verrucous Carcinoma of the Larynx Recruiting Phase 1 Trials for Paclitaxel (DB01229). Back to Recurrent Verrucous ... DBCOND0029506 (Recurrent Verrucous Carcinoma of the Larynx). Recruiting. 1. clinicaltrials.gov Identifier. Title. Purpose. ...
more infohttps://www.drugbank.ca/indications/DBCOND0029506/clinical_trials/DB01229?phase=1&status=recruiting

Verrucous Carcinoma in External Auditory Canal - A Rare Case - Open Access LibraryVerrucous Carcinoma in External Auditory Canal - A Rare Case - Open Access Library

Verrucous carcinoma is a variant of squamous cell carcinoma. It is of low grade malignancy and rarely present with distant ... Verrucous carcinoma is a variant of squamous cell carcinoma. It is of low grade malignancy and rarely present with distant ... Verrucous carcinoma in external auditory canal is extremely rare. This is the presentation of a 45 years old woman who came to ... Squamous Cell Carcinoma of the External Auditory Canal: A Case Report. Adenoid cystic carcinoma of the external auditory canal ...
more infohttp://www.oalib.com/paper/2759295

Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report
							| Colombia...Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report | Colombia...

According to this model, secondary immunodeficiency caused by HTLV-1 may induce the development of verrucous carcinomas; ... Biopsies were taken, which showed verrucous epidermal carcinoma and cutaneous lymphoma. Splenomegaly and adenopathy in ... atypical and exaggerated manifestations of verrucous carcinoma have also been described.. Case report:. We present here the ... Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report DOI: https://doi. ...
more infohttp://colombiamedica.univalle.edu.co/index.php/comedica/article/view/2174

Carcinoma, VerrucousCarcinoma, Verrucous

Verrucous. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Ranked list of diseases related to "Carcinoma, Verrucous"Drugs, active principles and "Carcinoma, Verrucous"Medicinal plants ... Carcinoma, Verrucous. A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also ...
more infohttps://lookfordiagnosis.com/mesh_info.php?term=Carcinoma%2C+Verrucous&lang=1

Verrucous Carcinoma  سرطانة ثؤلوليةVerrucous Carcinoma سرطانة ثؤلولية

Verrucous Carcinoma is a diffuse papillary, non metastasizing, well differentiated malignant neoplasm of the oral epithelium. ... Verrucous Carcinoma. Definition:. Verrucous Carcinoma is a diffuse papillary, non metastasizing, well differentiated malignant ...
more infohttp://dental.syriaforums.net/t261-topic

Alfa img - Showing > Verrucous...Alfa img - Showing > Verrucous...

Verrucous carcinoma(VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ...
more infohttp://alfa-img.com/show/verrucous-carcinoma.html

Verrucous carcinoma of the scalp by Sean F. Pattee, Jeremy S. Bordeaux et al."Verrucous carcinoma of the scalp" by Sean F. Pattee, Jeremy S. Bordeaux et al.

We present a case of verrucous carcinoma arising on the scalp with negative human papillomavirus testing in a relatively young ... with rare case reports of verrucous carcinoma arising elsewhere on the body. Human papillomaviruses, predominately types 6 and ... Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. It typically involves the oral cavity, larynx, ... Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. It typically involves the oral cavity, larynx, ...
more infohttps://escholarship.umassmed.edu/derm_pubs/28/

Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case report | Journal of Medical Case Reports |...Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case report | Journal of Medical Case Reports |...

These features are consistent with the growth pattern of verrucous carcinoma. Verrucous carcinoma can manifest as a small mass ... In most cases, verrucous carcinoma presents as an exophytic, slow-growing mass with an extensive superficial growth pattern. ... We must consider that verrucous carcinoma can manifest as appearance of a polyp that is not papillary or warty-like with and ... In a patient presenting with super early-stage verrucous carcinoma, we were able to eliminate the aberration using endoscopic ...
more infohttps://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-0866-y

NAVER Academic | Oral verrucous carcinoma: a retrospective study in São Paulo Region, Brazil.NAVER Academic | Oral verrucous carcinoma: a retrospective study in São Paulo Region, Brazil.

Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck. A Ferlito et al. Annals of ... Verrucous Carcinoma Buschke-Lowenstein Tumor) (1991) Hank K. Fung et al. * Papillary squamous cell carcinoma of the head and ... Verrucous carcinoma of the oral cavity. A review of forty-nine cases. J M McCoy et al. Oral surgery, oral medicine and oral ... Verrucous carcinoma. Clinical and pathologic study of 105 cases involving oral cavity, larynx and genitalia. F T Kraus et al. ...
more infohttp://academic.naver.com/article.naver?doc_id=147087824
  • An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm 2 irradiations at 634-nm wavelength. (em-consulte.com)
  • Verrucous carcinoma of the renal pelvis: case presentation and review of the literature. (naver.com)
  • Cancers from distant sites that metastasize to the vagina through the blood or lymphatic system also occur, including colon cancer, renal cell carcinoma, melanoma , and breast cancer. (medscape.com)
  • Tokunaga M, Uto H, Oda K, Mawatari S, Kumagai K, Haraguchi K. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. (univalle.edu.co)
  • To improve outcomes of primary vaginal carcinoma, select referral oncology centers should see additional cases per month in order to plan appropriate randomized, prospective studies. (medscape.com)
  • This would increase the experience of any of these centers in treating primary vaginal carcinoma. (medscape.com)
  • Review of literature confirms the rarity of cases of cholesteatoma which could progress and present as verrucous carcinoma in the postauricular region. (manipal.edu)