Carcinoma verrucous. Medical search

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

Tumors or cancer of the LIVER.

An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.

A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.

A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.

Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)

A malignant epithelial tumor with a glandular organization.

A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)

A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

Tumors or cancer of the NASOPHARYNX.

A cell line derived from cultured tumor cells.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Tumors or cancer of the THYROID GLAND.

Tumors or cancer of the human BREAST.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Tumors or cancer of the LUNG.

A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)

A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.

An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)

Tumors or cancer of the ESOPHAGUS.

Tumors or cancer of the MOUTH.

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.

Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.

Tumors or cancer of the COLON.

A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)

A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Tumors or cancer of the URINARY BLADDER.

Tumors or cancer of the STOMACH.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tumors or cancer of the SKIN.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)

DNA present in neoplastic tissue.

Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Tumors or cancer of the UTERINE CERVIX.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Experimental transplantation of neoplasms in laboratory animals for research purposes.

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)

A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)

Tumors or cancer of the gallbladder.

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.

An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.

Tumors or cancer of the TONGUE.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

Tumors or cancer of the BRONCHI.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Tumors or cancer of the SALIVARY GLANDS.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Elements of limited time intervals, contributing to particular results or situations.

RNA present in neoplastic tissue.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Transplantation between animals of different species.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Antibodies produced by a single clone of cells.

A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.

Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)

A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

Surgical removal of the thyroid gland. (Dorland, 28th ed)

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.

Tumors or cancer of the RECTUM.

A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

Experimentally induced tumors of the LIVER.

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

Tumors or cancers of the ADRENAL CORTEX.

The epithelial lining of the URINARY TRACT.

Tumors or cancer of the VULVA.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

Tumors or cancer of the OROPHARYNX.

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.

Compounds that include the amino-N-phenylamide structure.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.

Tumors or cancer of the BILE DUCTS.

An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)

Tumors or cancer of the URINARY TRACT in either the male or the female.

An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.

A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)

A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.

Established cell cultures that have the potential to propagate indefinitely.

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

Organic salts and esters of benzenesulfonic acid.

Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.

They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Biochemical identification of mutational changes in a nucleotide sequence.

Excision of all or part of the liver. (Dorland, 28th ed)

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Excision of kidney.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.

A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).

An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)

Tumors of cancer of the EYELIDS.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.

A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.

The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)

An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.

A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.

A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)

Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.

Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.

Tumors or cancer of the PHARYNX.

Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.

Tumors or cancer of the HYPOPHARYNX.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Verrucous carcinoma of the female breast. (1/43)

Verrucous carcinoma is a rare skin malignancy of squamous cell origin. It is characterised by negligible cellular atypia and a low mitotic rate. These are reflected in slow locally invasive behaviour and very infrequent metastatic spread. The tumour is also recognised in oral and anogenital sites. Cutaneous lesions present most commonly on the sole of the foot. We report a unique case occurring in the female breast. (+info)

Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions. (2/43)

Nonmalignant tobacco-associated lesions of the oral cavity were discussed in the first part of this two-part article. Here, we describe malignant lesions associated with tobacco use, basic biopsy principles for such lesions and intervention strategies that dental professionals may use to reduce the chances of their patients developing precancerous lesions or primary malignancies. (+info)

Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. (3/43)

BACKGROUND: Understanding the molecular mechanisms of metastasis is critical with respect to oral tumorigenesis. The focal adhesion kinase (FAK) is an intracellular tyrosine kinase associated with the regulation of cell growth, migration, and survival. The purpose of the current study was to determine whether elevated FAK expression in oral malignancies was associated with increased invasiveness and oral carcinoma. METHODS: Immunohistochemical analysis was used to assess levels of FAK expression in archived oral carcinoma tissue samples. Invasion assays after transfections were used to assess the effect of increased FAK expression on invasive potential of oral tumor cells. RESULTS: The human oral carcinoma cell line SCC25 was significantly more invasive (P < 0.05) and expressed higher levels of FAK compared with the less invasive human oral carcinoma cell line SCC15. FAK expression was 3.0-fold higher in the SCC15 cell line and 5.0-fold higher in the SCC25 cell line compared with normal epithelial cells. In the highly invasive SCC25 cell line, FAK expression was 1.5-fold higher compared with the less invasive SCC15 cell line. FAK immunostaining in oral tumors was significantly more intense compared with the immunostaining in surrounding normal epithelium or chronic mucositis. Overexpression of FAK in low-invading SCC15 cells resulted in a 4.5-fold increase in the rate of invasion compared with untransfected or neotransfected control SCC15 cell lines and a nearly 1.5-fold greater rate compared with the highly invasive untransfected SCC25 cell line. CONCLUSIONS: The current results suggest that enhanced expression of FAK in oral carcinoma cells may lead to a selective growth advantage and increased invasive potential of the primary oral tumor. (+info)

Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma. (4/43)

PURPOSE: Oral verrucous carcinoma (VC) has been traditionally treated with surgery or radiation with frequent recurrences and significant morbidity. We describe rapid and dramatic response to oral capecitabine in two patients with advanced refractory VC. EXPERIMENTAL DESIGN: VC is a rare tumor of the oral cavity. It does not metastasize but over time causes morbidity and mortality through local invasion. Radiation and surgery have been the main treatment modalities but are plagued by mutilating effects, recurrences, and possibly malignant degeneration in some cases. To date, no effective chemotherapy regimens have been described in the international literature. The clinical records of two elderly females with extensive oral VC are described. Both patients were prescribed one cycle of capecitabine, 1,000 mg bid for 14 days. Response was documented by photography in one patient. Immunohistochemical evaluation of three 5-fluorouracil metabolizing enzymes on pretreatment biopsies from both patients was also performed. A review of the literature with emphasis on treatment of oral VC is presented in view of our findings. RESULTS: Examination of the oral cavity before treatment revealed extensive involvement with an evenly spreading, exophytic, warty, whitish lesion in both patients. Microscopic examination of H&E-stained slides from biopsies of these lesions confirmed the clinical suspicion of VC. Both patients underwent treatment with oral capecitabine for one cycle (2 weeks on/1 week off) at a reduced dose of 1000 mg, p.o., bid. Both had a dramatic response with near complete resolution of their lesions within 3 weeks of initiating therapy. A durable partial response was documented at 1 year in the first patient and 6 months in the second. Immunohistochemical evaluation of pretreatment biopsies from both patients revealed a high level of expression of thymidine phosphorylase, a key enzyme in the metabolism of capecitabine. CONCLUSIONS: Oral VC is a rare entity with a progressive course over years and limited options in terms of treatment. Preliminary observations in two elderly patients demonstrate that capecitabine, an oral fluoropyrimidine, is well tolerated and may induce rapid, clinically significant response. Although not curative, it may provide a cost-effective alternative for elderly patients with a significant improvement in their quality of life. (+info)

Invasive cutaneous verruco-cystic squamous cell carcinoma. A pattern commonly present in transplant recipients. (5/43)

To determine whether certain histologic features are more common in cutaneous squamous cell carcinomas (CSCCs) arising in transplant recipients than in others, we assessed several features of CSCCs from 23 patients who had not undergone transplantation and 25 transplant recipients (size, depth of invasion, sun damage, nuclear atypia, keratinization, epidermal inclusion cyst [EIC]-like features, verrucous features [VFs], shape, and mitoses per 10 high-power fields). We analyzed relationships by using chi 2 and t tests and logistic regression analysis. Transplant recipients tended to be younger than control subjects (mean [SD] age, 56.2 [14.3]; 74.1 [10.6], respectively; P < .0001) and less likely to show severe sun damage (P = .0455; chi 2). CSCCs with VFs and EIC-like features were associated strongly with transplantation: odds ratio, 12.57 (95% confidence interval, 1.28-123.47; P = .0162). No other features were associated significantly with transplant status. Posttransplant tumors commonly showed verrucous and EIC-like features mimicking benign conditions. The younger age of these patients, the frequent absence of solar elastosis, and the infrequent occurrence of well-differentiated verruco-cystic CSCC in the nontransplant population suggest a different pathogenesis in the development of these neoplasms. Pathologists should be aware of this pattern, especially when diagnosing small biopsy specimens from transplant recipients. (+info)

Surgical treatment of oral verrucous carcinoma. (6/43)

BACKGROUND: The aim of this study was to evaluate the outcome of patients with Verrucous carcinoma (VC) of oral cavity treated at the Chung Gung Memory Hospital with respect to the tumor control rates after surgery, the risk of lymph node metastasis and the role of radiation therapy. METHODS: Thirty-eight patients underwent primary treatment for VC of the oral cavity from January 1996 through February 2002. All of the patients had surgery as their primary treatment. In addition, all patients with sufficient details of the therapy and a minimum 1-year follow-up were selected for evaluation of survival and outcomes. RESULTS: In this study, 94.7% of patients were male and most of them had been exposed to betel nuts, cigarettes, and/or alcohol. The most common site was the buccal mucosa (57.9%), followed by the tongue (13.2%). T3 lesions were the most common type (34.2%). Only two patients had palpable cervical adenopathy during the initial evaluation. Twenty-five patients had free flap for reconstruction. The tumor control rate was 100%. At the time of analysis, no patient had suffered from recurrence in primary site or neck area. CONCLUSION: Surgical excision alone was effective for controlling VC, but elective neck dissection was not necessary even in patients in the advanced stages. (+info)

Verrucous carcinoma of the bladder with koilocytosis unassociated with vesical schistosomiasis. (7/43)

CONTEXT: Verrucous carcinoma of the bladder is a very rare malignant neoplasm, histologically similar to condyloma acuminatum. Usually it shows association with vesical schistosomiasis (bilharziasis). Only 13 cases unrelated to bilharziasis have been reported to date, and none of them reported koilocytosis, a typical finding in human papillomavirus infection. CASE REPORT: We report a case of verrucous carcinoma of the bladder that was unrelated to bilharziasis, with koilocytosis and absence of human papillomavirus. The literature relating to the topic is discussed. (+info)

Association of laryngeal cancer with previous gastric resection. (8/43)

OBJECTIVE: To investigate the association between gastric surgery and cancer of the larynx. SUMMARY BACKGROUND DATA: Biliary reflux is frequent after gastric surgery and may reach the proximal segment of the esophagus and the larynx. It is possible that duodenal content (consisting in bile acids, trypsin), together with pepsin and acid residues when gastric resection is partial, may cause harmful action on the multistratified epithelium of the larynx. METHODS: A retrospective case-control study on subjects admitted between January 1987 and May 2002 in the same hospital in Rome was carried out. The study included 828 consecutive patients with laryngeal cancer (cases) and 825 controls with acute myocardial infarction. Controls were randomly sampled out of a total of 10,000 and matched with cases for age, sex, and year of admission. Logistic regression models were used to assess the role of gastric resection in determining laryngeal cancer risk while controlling for potential confounding factors. RESULTS: Previous gastrectomy was reported by 8.1% of cases and 1.8% of the controls (P < 0.0001). A 4-fold association emerged between gastric surgery and laryngeal cancer risk (adjusted OR = 4.3, 95% CI: 2.4-7.9). The risk appeared strongly increased 20 years after surgery (OR = 14.8, 95% CI: 3.4-64.6). Heavy alcohol drinking (OR = 2.5, 95% CI: 1.8-3.5), smoking (OR = 4.7, 95% CI: 3.3-6.7), and blue-collar occupation (OR = 4.6, 95% CI: 3.2-6.7) were all independently associated with the risk of laryngeal cancer. CONCLUSIONS: Previous gastric surgery is associated with an increased risk of laryngeal cancer. A periodic laryngeal examination should be considered in long-term follow-up of patients with gastric resection. (+info)

Tis: Carcinoma in situ. Ta: Noninvasive verrucous carcinoma. T1a: Tumor invades subepithelial connective tissue without lymph ... Other types of penile cancer such as Merkel cell carcinoma, small cell carcinoma, and melanoma are generally rare. In 2018, it ... sarcomatoid carcinomas (1%) not otherwise specified (49%) Other types of carcinomas are rare and may include small cell, Merkel ... carcinoma in situ-Bowen's disease, Erythroplasia of Queyrat and bowenoid papulosis (BP)); Invasive carcinoma of the penis. ...

https://en.wikipedia.org/wiki/Penile_cancer

ISBN 0-7216-2921-0. Monticciolo NL, Schmidt JD, Morgan MB (2002). "Verrucous carcinoma arising within syringocystadenoma ...

https://en.wikipedia.org/wiki/Syringocystadenoma_papilliferum

This is a type of verrucous carcinoma. Mucous membrane Erythroplakia Proliferative verrucous leukoplakia List of cutaneous ... conditions List of verrucous carcinoma subtypes James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the ...

https://en.wikipedia.org/wiki/Oral_florid_papillomatosis

Squamous cell carcinoma no Keratinizing, Nonkeratininzing, Basalaoid, Verrucous, Warty [16][17][18] ... Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... these include leukemia and most forms of carcinoma in situ. Tumor is also not synonymous with cancer. While cancer is by ...

https://en.wikipedia.org/wiki/List_of_vaginal_tumors

List of cutaneous conditions List of verrucous carcinoma subtypes Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. ( ... wart-like growth that is a verrucous carcinoma. It is attributed to human papillomavirus. Due to their size, these tumors can ... In general these masses are benign, but the potential for malignant transformation to squamous cell carcinoma exists in the ...

https://en.wikipedia.org/wiki/Giant_condyloma_acuminatum

Unilateral palmoplantar verrucous nevus Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume ... Pathology studies are necessary to distinguish carcinoma of the urethra from urethral caruncles. Caruncles can grow back in ...

https://en.wikipedia.org/wiki/Urethral_caruncle

Verrucous carcinoma List of cutaneous conditions List of verrucous carcinoma subtypes Rapini, Ronald P.; Bolognia, Jean L.; ... is a cutaneous condition characterized by verrucous skin lesions, and is due to an HPV infection of the skin. ...

https://en.wikipedia.org/wiki/Papillomatosis_cutis_carcinoides

It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... "Hybrid verrucous carcinoma of the oral cavity: A challenge for the clinician and the pathologist". Oral Oncology Extra. 42 (2 ... They found that the larynx was extensively damaged by ulceration, and microscopic examination confirmed epidermal carcinoma. ... carcinoma in the modern sense) were inherently associated with white blood cells (which are now called macrophages) that ...

https://en.wikipedia.org/wiki/Rudolf_Virchow

There is relatively low risk of transformation of this lesion into mouth cancer (sometimes verrucous carcinoma). Dipping ...

https://en.wikipedia.org/wiki/Dipping_tobacco

There is a very high risk of dysplasia and transformation to OSCC or to verrucous carcinoma. Erythroleukoplakia (also termed ... Verrucous leukoplakias are usually heavily keratinized and are often seen in elderly people. Some verrucous leukoplakias may ... Proliferative verrucous leukoplakia (PVL) is a recognized high risk subtype of non-homogenous leukoplakia. It is uncommon, and ... Verrucous or nodular areas have a higher risk. Although smoking increases risk of malignant transformation, smoking also causes ...

https://en.wikipedia.org/wiki/Leukoplakia

... generally squamous cell carcinoma and its variant verrucous carcinoma) is relatively low. Indeed, veruccous carcinoma is ... Snuff dipping is associated more with verrucous keratosis. As well as the white changes of the oral mucosa, there may be ... The differential diagnosis includes other oral white lesions such as Leukoplakia, squamous cell carcinoma, oral candidiasis, ...

https://en.wikipedia.org/wiki/Smokeless_tobacco_keratosis

A verrucous carcinoma of the vulva is a rare subtype of squamous cell cancer and tends to appear as a slowly growing wart. ... Carcinoma-in-situ is a precursor lesion of squamous cell cancer that does not invade through the basement membrane. There are ... Verrucous vulvar cancers tend to have a good overall prognosis, as these lesions hardly ever spread to regional lymph nodes or ... Basal cell carcinoma account for approximately 8% of all vulvar cancers. It typically affects women in the 7th and 8th decade ...

https://en.wikipedia.org/wiki/Vulvar_cancer

Tis (carcinoma in situ) has been eliminated and the division of T4 into substages (e.g. T4a) has been removed. The major ... HPV16 E6/E7-positive cases are histopathologically characterized by their verrucous or papillary (nipple like) structure and ... Durmus, K; Rangarajan, SV; Old, MO; Agrawal, A; Teknos, TN; Ozer, E (June 2014). "Transoral robotic approach to carcinoma of ... Ragin, Camille C. R.; Taioli, Emanuela (15 October 2007). "Survival of squamous cell carcinoma of the head and neck in relation ...

https://en.wikipedia.org/wiki/HPV-positive_oropharyngeal_cancer

... and verrucous carcinoma. Adenoma is the most common colorectal polyp. Adenomas are not malignant, but rarely adenocarcinoma can ... Because these symptoms are so unspecific, and because symptoms of anal carcinoma may not always be typical, this can lead to ... Jensen, SL; Hagen, K; Shokouh-Amiri, MH; Nielsen, OV (May 1987). "Does an erroneous diagnosis of squamous-cell carcinoma of the ... The most common form is squamous cell carcinoma, followed by adenocarcinoma and melanoma. SCC usually occurs in the anal canal ...

https://en.wikipedia.org/wiki/Rectal_discharge

... analysis of the specimen finally confirmed the tumor to be verrucous carcinoma, a low-grade epithelial cancer with a low ... Keen, stated after Cleveland's death that the tumor was a carcinoma. Other suggestions included ameloblastoma or a benign ...

https://en.wikipedia.org/wiki/Grover_Cleveland

Two related types of cancer of the larynx, namely squamous cell carcinoma and verrucous carcinoma, are strongly associated with ...

https://en.wikipedia.org/wiki/Larynx

It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... "Hybrid verrucous carcinoma of the oral cavity: A challenge for the clinician and the pathologist". Oral Oncology Extra. 42 (2 ... First described by Karl Thiersch in the 1860s.)[42] But he made a crucial observation that certain cancers (carcinoma in modern ... They found that the larynx was extensively damaged due to ulcer, and microscopic examination confirmed epidermal carcinoma. Die ...

https://en.m.wikipedia.org/wiki/Rudolf_Virchow

... integumentary system List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

https://en.wikipedia.org/wiki/List_of_histologic_stains_that_aid_in_diagnosis_of_cutaneous_conditions

... fibroma Trichodiscoma Trichofolliculoma Unilateral palmoplantar verrucous nevus Urethral caruncle Verrucous carcinoma Verrucous ... verrucous seborrheic keratosis) Superficial basal cell carcinoma (superficial multicentric basal cell carcinoma) Syringadenoma ... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ... Microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) Micronodular basal cell carcinoma Milia en plaque Milium Mixed ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

... and verrucous carcinoma Surgical excision is the treatment of choice. Verruciform xanthoma is uncommon, with a female:male ... Haustein UF (1984). "[Xanthomatous cells in inflammatory linear verrucous epidermal nevus or nevoid verruciform xanthoma?]". ...

https://en.wikipedia.org/wiki/Verruciform_xanthoma

actinic keratosis Bowen's disease (intraepidermal carcinoma/squamous carcinoma in situ) dyskeratosis congenita ductal carcinoma ... leukoplakia proliferative verrucous leukoplakia stomatitis nicotina Barrett's esophagus atrophic gastritis colon polyp Plummer- ... Sometimes the term "precancer" is also used for carcinoma in situ, which is a noninvasive cancer that has not progressed to an ... As with other precancerous conditions, not all carcinoma in situ will progress to invasive disease. The term precancerous or ...

https://en.wikipedia.org/wiki/Precancerous_condition

... integumentary system List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

https://en.wikipedia.org/wiki/List_of_cutaneous_neoplasms_associated_with_systemic_syndromes

NOS M8051/0 Verrucous papilloma M8051/3 Verrucous carcinoma, NOS Condylomatous carcinoma Verrucous squamous cell carcinoma ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... Renal cell carcinoma, spindle cell M8319/3 collecting duct carcinoma (C64.9) Bellini duct carcinoma Renal carcinoma, collecting ... NOS Intraepithelial squamous cell carcinoma M8070/3 Squamous cell carcinoma, NOS Epidermoid carcinoma, NOS Squamous carcinoma ...

https://en.wikipedia.org/wiki/International_Classification_of_Diseases_for_Oncology

... with cutaneous reactions List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

https://en.wikipedia.org/wiki/List_of_migrating_cutaneous_conditions

... with cutaneous reactions List of target antigens in pemphigoid List of target antigens in pemphigus List of verrucous carcinoma ...

https://en.wikipedia.org/wiki/List_of_mites_associated_with_cutaneous_reactions

List of cutaneous conditions List of cutaneous conditions caused by mutations in keratins List of verrucous carcinoma subtypes ...

https://en.wikipedia.org/wiki/Epidermolytic_hyperkeratosis

... carcinoma Verrucous lupus erythematosus Proliferative verrucous leukoplakia Verrucous perforating collagenoma ... Verrucous cyst Verrucous vascular malformation Unilateral palmoplantar verrucous nevus This disambiguation page lists articles ... Verrucous (appearing like a wart or "verruca") can refer to: ... associated with the title Verrucous. If an internal link led ...

https://en.wikipedia.org/wiki/Verrucous

... (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ... Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis ... National survey of head and neck verrucous carcinoma. Cancer 2001;92:110-20 McDonald JS, Crissman JD, Gluckman JL. Verrucous ... Epithelioma cuniculatum (also known as Carcinoma cuniculatum, and Ackerman tumor) is a subtype of verrucous carcinoma, ...

https://en.wikipedia.org/wiki/Verrucous_carcinoma

Squamous cell carcinomas have been reported to develop in Mibelli's type porokeratosis over partianal areas involving anal ... hyperkeratotic or verrucous plaques. Sometimes they may show gross overgrowth and even horn-like structures may develop. Skin ... ISBN 0-7216-2921-0. Familial disseminated plaque type porokeratosis with multiple horns and squamous cell carcinoma involving ...

https://en.wikipedia.org/wiki/Porokeratosis

Verrucous squamous cell carcinoma (code 8051/3) Papillary squamous cell carcinoma (code 8052/3) Squamous cell carcinoma (code ... Adenoid squamous cell carcinoma Basaloid squamous cell carcinoma Clear-cell squamous cell carcinoma Spindle-cell squamous cell ... Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different types of cancer that ... Basaloid squamous cell carcinoma is characterized by a predilection for the tongue base. Clear-cell squamous cell carcinoma ( ...

https://en.wikipedia.org/wiki/Squamous_cell_carcinoma

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ...

https://en.wikipedia.org/wiki/Gastrointestinal_carcinoid_tumor

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ... Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Li TJ, Cui J (August 2013). "COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma". Asian Pacific ... It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[12][33] ...

https://en.wikipedia.org/wiki/Lupus_erythematosus–lichen_planus_overlap_syndrome

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ...

https://en.wikipedia.org/wiki/Carcinomas

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ... Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ...

https://en.wikipedia.org/wiki/Aphthous_stomatitis

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Dentin_hypersensitivity

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Somatostatinoma

Verrucous: wart-like. Distribution[edit]. "Distribution" refers to how lesions are localized. They may be confined to a single ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...

https://en.wikipedia.org/wiki/Cutaneous_conditions

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Hepatocellular_adenoma

Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma. *Verrucous carcinoma ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... The incidence of squamous cell carcinoma increases to 37% when the cutaneous horn is present on the penis.[3] Tenderness at the ... Malignancy is present in up to 20% of cases, with squamous cell carcinoma being the most common type. ...

https://en.wikipedia.org/wiki/Cutaneous_horn

squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Verrucous. *Rowell's syndrome. Scleroderma/. Morphea. *Localized scleroderma *Localized morphea. *Morphea-lichen sclerosus et ...

https://en.wikipedia.org/wiki/Callus

Combined small cell carcinoma（英语：Combined small-cell carcinoma）. *Verrucous carcinoma（英语：Verrucous carcinoma） ... Medullary carcinoma（英语：Medullary carcinoma）. *Medullary carcinoma of the breast（英语：Medullary carcinoma of the breast） ... Lobular carcinoma（英语：Lobular carcinoma）. *Lobular carcinoma in situ（英语：Lobular carcinoma in situ） ... Ductal carcinoma（英语：Ductal carcinoma）. *Mammary ductal carcinoma（英语：Mammary ductal carcinoma） ...

https://zh.wikipedia.org/wiki/印戒细胞癌

Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma. *Verrucous carcinoma ... "Squamous cell carcinoma (epidermoid carcinoma) - skin". Atlas of Pathology (3rd ed.). Universitatii St., Iasi, Romania. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... whereas it might be inadequate for invasive nodular basal-cell carcinoma or invasive squamous-cell carcinoma.[citation needed] ...

https://en.wikipedia.org/wiki/Skin_cancer

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Black_hairy_tongue

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ... The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ... Malignancies in the mouth are usually carcinomas, but lymphomas, sarcomas and others may also be possible. Either the tumor ...

https://en.wikipedia.org/wiki/Mouth_ulcer

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ... Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one ... particularly breast and lung carcinoma.[1] It is not associated with H. pylori infection or chronic gastritis. The risk factors ...

https://en.wikipedia.org/wiki/Linitis_plastica

Two related types of cancer of the larynx, namely squamous cell carcinoma and verrucous carcinoma, are strongly associated with ...

https://simple.wikipedia.org/wiki/Larynx

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Gingival_inflammation

Pilepich MV, Asbell SO, Mulholland GS, Pajak T (1984). "Surgical staging in carcinoma of the prostate: the RTOG experience. ... As the disorder progresses, worsening edema and skin changes including discoloration, verrucous (wart-like) hyperplasia, ... October 1984). "Treatment-related morbidity in phase III RTOG studies of extended-field irradiation for carcinoma of the ... "Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a ...

https://en.m.wikipedia.org/wiki/Chronic_lymphedema

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Herpes

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Eagle_syndrome

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://fa.wikipedia.org/wiki/زونا?match=en

Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Behçet’s_disease

Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma. *Verrucous carcinoma ... Moy, RL (Jan 2000). "Clinical presentation of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ...

https://en.wikipedia.org/wiki/Actinic_keratosis

Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Warts

squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Verrucous epidermal nevus. *Nevus sebaceous. *Nevus comedonicus. *Eccrine nevus. *Apocrine nevus. Connective tissue nevi[edit] ...

https://en.wikipedia.org/wiki/Mole_(skin_marking)

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ... Sipple JH (1961). "The association of pheochromocytoma with carcinoma of the thyroid gland". Am. J. Med. 31: 163-6. doi:10.1016 ... In 1959 Hazard et al. described medullary (solid) thyroid carcinoma. In 1961 Sipple described a combination of a ... Micrograph of a medullary thyroid carcinoma, as may be seen in MEN 2A and MEN 2B. H&E stain. ...

https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia

basal cell carcinoma, squamous cell carcinoma, intraepidermal carcinoma [58] Fanconi anemia genes FANCA, B, C, D1, D2, E, F, G ... sarcomas, breast cancers, brain tumors, and adrenocortical carcinomas [69] NTHL1 NTHL1 BER for Tg, FapyG, 5-hC, 5-hU in dsDNA[ ...

https://en.wikipedia.org/wiki/DNA_repair-deficiency_disorder

Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ...

https://en.wikipedia.org/wiki/Warthin's_tumor

Papilloma/carcinoma. *Small-cell carcinoma. *Combined small-cell carcinoma. *Verrucous carcinoma. *Squamous cell carcinoma ...

https://en.wikipedia.org/wiki/Prolactinoma

Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ... Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis ... National survey of head and neck verrucous carcinoma. Cancer 2001;92:110-20 McDonald JS, Crissman JD, Gluckman JL. Verrucous ... Epithelioma cuniculatum (also known as Carcinoma cuniculatum, and Ackerman tumor) is a subtype of verrucous carcinoma, ...

https://en.wikipedia.org/wiki/Verrucous_carcinoma

Several subtypes of verrucous carcinoma have been described. Treatment of verrucous carcinoma with radiation therapy should be ... Verrucous carcinoma is a type of squamous cell carcinoma that may be associated with HPV infection (may be subtypes 16 or 18, ...

https://en.wikipedia.org/wiki/List_of_verrucous_carcinoma_subtypes

Home Education AUAUniversity Education Products & Resources Pathology for Urologists Penis Carcinomas Verrucous Carcinoma ... Radiation should be avoided as it may cause the verrucous carcinoma to dedifferentiate into a highly aggressive spindle cell ... Clinical: Rare, accounts ~4% of penile carcinoma.. *Gross: Exophytic tumor with papillary or spiky surface affecting the glans ... Well-differentiated squamous cell carcinoma with broad pushing borders rather than the finger-like infiltrative borders of a ...

http://auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/penis/carcinomas/verrucous-carcinoma

R. H. Spiro, "Verrucous carcinoma, then and now," American Journal of Surgery, vol. 176, no. 5, pp. 393-397, 1998. View at ... L. V. Ackerman, "Verrucous carcinoma of the oral cavity," Surgery, vol. 23, no. 4, pp. 670-678, 1948. View at Google Scholar · ... Oral Verrucous Carcinoma Mimicking a Chronic Candidiasis: A Case Report. Natália Galvão Garcia,1 Denise Tostes Oliveira,1 João ... J. M. McCoy and C. A. Waldron, "Verrucous carcinoma of the oral cavity. A review of forty-nine cases," Oral Surgery Oral ...

https://www.hindawi.com/journals/crionm/2012/190272/ref/

... Masahiro Kawaida,1 Hiroyuki Fukuda,2 and Naoyuki Kohno3 ... A patient was encountered with verrucous carcinoma of the larynx that presented as a hairy whitish tumor. There was a ...

https://www.hindawi.com/journals/dte/1997/864231/abs/

Warty / condylomatous carcinoma: prominent cytoplasmic halos around tumor cells End of Cervix > Carcinoma > Verrucous carcinoma ... Carcinoma. Verrucous carcinoma. Reviewer: Dr. Branko Perunovic (see Reviewers page). Revised: 13 June 2016, last major update ... Squamous cell carcinoma with papillary growth pattern: usually has finger-like invasive tongues, marked nuclear atypia * ... One paper claims that HPV+ cases are better classified as SIL, giant condyloma or invasive squamous cell carcinoma (Can J Surg ...

http://www.pathologyoutlines.com/topic/cervixverrucous.html

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...

https://www.drugbank.ca/indications/DBCOND0029506

57 - N° 3 - p. 516-519 - Photodynamic therapy for cutaneous verrucous carcinoma - EM,consulte ... Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm ... An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 ... The use of methyl-aminolevulinate-photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far ...

https://www.em-consulte.com/en/article/439018

Treatment options for verrucous carcinoma may depend on the location of the tumor, but they usually begin with surgery. During ... Continue Learning about Verrucous Carcinoma. Are there alternative treatments for verrucous carcinoma? ... Treatment options for verrucous carcinoma may depend on the location of the tumor, but they usually begin with surgery. During ... Verrucous carcinoma begins in certain cells in the skin or mucous membranes. When these cells grow o... ...

https://www.sharecare.com/health/verrucous-carcinoma/what-treatment-options-verrucous-carcinoma

PubMed journal article Endoscopic submucosal dissection for an atypical small verrucous carcinoma: a case repor were found in ... Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. In most cases, verrucous carcinoma ... Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. In most cases, verrucous carcinoma ... These features are consistent with the growth pattern of verrucous carcinoma. CONCLUSIONS: Verrucous carcinoma can manifest as ...

https://www.unboundmedicine.com/medline/citation/27036299/Endoscopic_submucosal_dissection_for_an_atypical_small_verrucous_carcinoma:_a_case_report_

Verrucous carcinomas, first described by Ackermann [1] in 1948, are rare, well-differentiated squamous cell carcinomas in the ... Verrucous carcinomas are rare, well-differentiated squamous cell carcinomas that in most cases seem to be confined to the basal ... While there are a number of reports on verrucous carcinomas of the larynx, we could not find any reports about verrucous ... the possibility of their being verrucous carcinomas should be borne in mind. We believe that a larger number of verrucous ...

http://erj.ersjournals.com/content/43/4/1198

... this lesion is a distinct and particular entity in the vulva carcinoma classification and its scalability is uncertain and ... this lesion is a distinct and particular entity in the vulva carcinoma classification and its scalability is uncertain and ... Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, ... Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, ...

https://www.frontiersin.org/articles/10.3389/fsurg.2016.00008/full

Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and... ... Verrucous carcinoma and giant condyloma of Buschke and Löwenstein are identical lesions. ... Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and Löwenstein. It is a ... 2017) Verrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein. In: Carneiro F., Chaves P., Ensari A. (eds) Pathology of ...

https://rd.springer.com/referenceworkentry/10.1007/978-3-319-40560-5_2864

This is often the appearance of a verrucous carcinoma of the larynx. ...

http://www.entusa.com/larynx_pictures_htm/larynx_leukoplakia-1.htm

Results We identified 732 patients with laryngeal verrucous carcinoma from NCDB. The majority were cTis-T2 (87%) N0 (96%). We ... We identified 732 patients with laryngeal verrucous carcinoma from the NCDB. The majority were cTis-T2 (87%) N0 (96%). We ... is a rare form of laryngeal squamous cell carcinoma. We analyzed the National Cancer Database (NCDB) to examine national ... is a rare form of laryngeal squamous cell carcinoma. We analyzed the National Cancer Database (NCDB) to examine national ...

https://www.frontiersin.org/articles/10.3389/fonc.2020.01241/full

Verrucous Carcinoma Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2016* *Proportion of Verrucous Carcinoma to ... Verrucous Carcinoma Therapeutics, G7 Countries, Clinical Trials by Trial Status, 2016* *Proportion of Verrucous Carcinoma to ... Verrucous Carcinoma Therapeutics, Global, Clinical Trials and Average Enrollment by Top Countries, 2016* *Verrucous Carcinoma ... Proportion of Verrucous Carcinoma to Oncology Clinical Trials, G7 Countries (%), 2016* *Verrucous Carcinoma Therapeutics, G7 ...

https://www.giiresearch.com/report/gd329833-verrucous-carcinoma-global-clinical-trials-review.html

Recurrent Verrucous Carcinoma of the Larynx Recruiting Phase 1 Trials for Paclitaxel (DB01229). Back to Recurrent Verrucous ... DBCOND0029506 (Recurrent Verrucous Carcinoma of the Larynx). Recruiting. 1. clinicaltrials.gov Identifier. Title. Purpose. ...

https://www.drugbank.ca/indications/DBCOND0029506/clinical_trials/DB01229?phase=1&status=recruiting

Abstract Introduction: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which ... Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma / ... in oral verrucous carcinoma and could be considered as a suitable prognostic marker in distinguishing oral verrucous carcinoma ... In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 ...

http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=LILACS&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D12.776.543.750.725.937

... associated squamous cell carcinoma. ... finding in the microenvironment of proliferative verrucous ...

https://insights.ovid.com/pubmed?PMID=27681951

According to this model, secondary immunodeficiency caused by HTLV-1 may induce the development of verrucous carcinomas; ... Biopsies were taken, which showed verrucous epidermal carcinoma and cutaneous lymphoma. Splenomegaly and adenopathy in ... atypical and exaggerated manifestations of verrucous carcinoma have also been described.. Case report:. We present here the ... Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report DOI: https://doi. ...

http://colombiamedica.univalle.edu.co/index.php/comedica/article/view/2174

Inverted papilloma of oral cavity masquerading as verrucous carcinoma: a diagnostic dilemma. Hari J. PILLAI 1 ✉, Samir GUPTA 2 ... Due to high index of suspicion of verrucous carcinoma on clinical presentation and imaging, patient underwent a composite ... Inverted papilloma of oral cavity masquerading as verrucous carcinoma: a diagnostic dilemma. Eur J Oral Maxillofac Surg 2017;1: ...

https://www.minervamedica.it/it/riviste/maxillofacial-surgery/articolo.php?cod=R53Y2017N03A0098

Verrucous carcinoma is a variant of squamous cell carcinoma. It is of low grade malignancy and rarely present with distant ... Verrucous carcinoma is a variant of squamous cell carcinoma. It is of low grade malignancy and rarely present with distant ... Verrucous carcinoma in external auditory canal is extremely rare. This is the presentation of a 45 years old woman who came to ... Squamous Cell Carcinoma of the External Auditory Canal: A Case Report. Adenoid cystic carcinoma of the external auditory canal ...

http://www.oalib.com/paper/2759295

... one expert recommends considering verrucous carcinoma in the differential diagnosis of ILVEN. Initial biopsies can be ... Because verrucous carcinoma and ILVEN can have striking histologic similarities, ... Verrucous carcinoma: Case shows verrucous carcinoma, ILVEN have striking histologic similarities. November 1, 2008 ... Because verrucous carcinoma and ILVEN can have striking histologic similarities, one expert recommends considering verrucous ...

https://www.dermatologytimes.com/view/verrucous-carcinoma-case-shows-verrucous-carcinoma-ilven-have-striking-histologic-similarities

The aim of this study was to examine the expression of transforming growth factor-alpha in proliferative verrucous leukoplakia ... Proliferative verrucous leukoplakia is a unique type of oral leukoplakia that has a high risk of malignant transformation. ... Transforming growth factor-alpha overexpression in proliferative verrucous leukoplakia and oral squamous cell carcinoma: An ... Ten cases each of normal mucosa, proliferative verrucous leukoplakia, and oral squamous cell carcinoma were stained. ...

https://insights.ovid.com/oral-surgery-medicine-pathology-radiology/oooo/1996/07/000/transforming-growth-factor-alpha-overexpression/13/00043790

We present a case of verrucous carcinoma arising on the scalp with negative human papillomavirus testing in a relatively young ... with rare case reports of verrucous carcinoma arising elsewhere on the body. Human papillomaviruses, predominately types 6 and ... Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. It typically involves the oral cavity, larynx, ... Verrucous carcinoma is a distinctive form of low-grade squamous cell carcinoma. It typically involves the oral cavity, larynx, ...

https://escholarship.umassmed.edu/derm_pubs/28/

Verrucous. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Ranked list of diseases related to "Carcinoma, Verrucous"Drugs, active principles and "Carcinoma, Verrucous"Medicinal plants ... Carcinoma, Verrucous. A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also ...

https://lookfordiagnosis.com/mesh_info.php?term=Carcinoma%2C+Verrucous&lang=1

A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, ... Verrucous Carcinoma. A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also ...

https://www.health-portal.net/disease/alphabetically/index_eng.html?disease=216982

DNA in verrucous carcinoma of the larynx. Together they form a unique fingerprint. * Verrucous Carcinoma Medicine & Life ... Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx. / ... Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx. ... title = "Polymerase chain reaction (PCR) identification of human papillomavirus (HPV) DNA in verrucous carcinoma of the larynx ...

https://mayoclinic.pure.elsevier.com/en/publications/polymerase-chain-reaction-pcr-identification-of-human-papillomavi

... is an uncommon variant of oral squamous cell carcinoma (OSCC). Its incidence is between 2% and 16% of all oral cancers. The ...

https://medizzy.com/feed/28603936

Verrucous carcinoma Verrucous carcinoma. Verrucous carcinoma is a variant of squamous cell carcinoma (SCCA). In the head and ... Verrucous carcinoma (1 of 5) Verrucous carcinoma, left vocal cord, persistent after radiotherapy elsewhere, in a patient unable ... Verrucous carcinoma, several weeks after laser treatment (5 of 5) During voicing. Arytenoid moves, but much of membranous vocal ... Verrucous carcinoma, after laser treatment (3 of 5) After several Thulium Laser ablations, using topical and injected local ...

https://laryngopedia.com/verrucous-carcinoma/

Proliferative verrucous leukoplakia is a unique type of oral leukoplakia that has a high risk of malignant transformation. (ovid.com)
The aim of this study was to examine the expression of transforming growth factor-alpha in proliferative verrucous leukoplakia, oral squamous cell carcinoma, and normal mucosa. (ovid.com)
Ten cases each of normal mucosa, proliferative verrucous leukoplakia, and oral squamous cell carcinoma were stained. (ovid.com)
Notably, the mean cytoplasmic optical density of proliferative verrucous leukoplakia was significantly higher than the mean cytoplasmic optical density of normal mucosa ( p (ovid.com)
The mean cytoplasmic optical density values demonstrate that increased transforming growth factor-alpha immunoreactivity occurs in proliferative verrucous leukoplakia and oral squamous cell carcinoma relative to normal mucosa. (ovid.com)
Verrucous carcinoma and proliferative verrucous leukoplakia, are among the injuries presenting difficult differential diagnosis due to histopathological similarities that occur at some stage of evolution. (usp.br)
Proliferative verrucous leukoplakia is characterized by its multifocal involvement, great potential for relapse and progressive profile that results in malignant transformation high risk. (usp.br)
The proliferative verrucous leukoplakia, since it is a lesion with high potential for malignant transformation, can develop into less differentiated and more aggressive invasive squamous cell carcinoma with subsequent poor prognosis, whereas the verrucous carcinoma incurs no metastases and presents a more favorable prognosis. (usp.br)

A patient was encountered with verrucous carcinoma of the larynx that presented as a hairy whitish tumor. (hindawi.com)
While there are a number of reports on verrucous carcinomas of the larynx, we could not find any reports about verrucous carcinomas in the tracheobronchial tree. (ersjournals.com)
Verrucous carcinoma of the larynx (VCL) is a rare form of laryngeal squamous cell carcinoma. (frontiersin.org)
Verrucous carcinoma of larynx (VCL) is a rare type of squamous cell carcinoma that comprises 1-4% of all primary laryngeal squamous cell cancers ( 1 , 2 ). (frontiersin.org)
We accessed the NCDB for patients diagnosed between 2004 and 2015 with verrucous carcinoma of the larynx (ICD-0-3 code C32, Histology code 8051/3). (frontiersin.org)
The incidence of human papillomavirus (HPV) DNA in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using polymerase chain reaction (PCR) with consensus primers and by in situ hybridization designed to detect HPV types 6/11, 16/18, 31/33/35. (elsevier.com)
We here report the case of a CS patient with a history of papillary thyroid carcinoma, developing the very unusual combination of malignant peritoneal mesothelioma (MPM) and well-differentiated verrucous (squamous cell) carcinomas (VC) involving the oropharynx and larynx, a co-occurrence of rare malignancies hitherto without precedent. (biomedcentral.com)
Verrucous carcinoma is a distinct morphologic variant of well differentiated squamous cell carcinoma that is most often seen in the oral cavity & larynx but extremely rare in the nasal cavity . (bvsalud.org)
The most common squamous carcinoma variants in the larynx are covered: spindle cell variant, papillary variant and verrucous carcinoma. (springer.com)
Stenner M, Müller KM, Koopmann M, Rudack C. Squamous cell carcinoma of the larynx arising in multifocal pharyngolaryngeal oncocytic papillary cystadenoma: a case report and review of the literature. (springer.com)

Verrucous carcinoma is a type of squamous cell carcinoma that may be associated with HPV infection (may be subtypes 16 or 18, but types 6 and 11 have also been reported, as have HPV negative variants). (wikipedia.org)
To determine which type of squamous cell carcinoma a patient has, a pathologist will examine a tissue sample underneath a microscope. (moffitt.org)
Verrucous carcinoma is an unusual type of squamous cell carcinoma. (cancerresearchuk.org)

Abstract Introduction: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. (bireme.br)

We present a case of verrucous carcinoma arising on the scalp with negative human papillomavirus testing in a relatively young patient. (umassmed.edu)
A case of verrucous carcinoma of the vulva is reported and the literature concerning verrucous carcinoma of the vulva is reviewed. (meta.org)
Rishard M, Ranaweera A, Seneviratne H, Kaluarachchi A, Abeygunawardane D. A rare case of verrucous carcinoma of the cervix in a patient with uterine prolapse. (sljol.info)
We have reported a long-term follow-up case of verrucous carcinoma of the esophagus that was difficult to diagnose before surgery. (springeropen.com)
We report a case of verrucous carcinoma found in the hard palate & the nasal floor and treated by surgical excision with a review of the literature . (bvsalud.org)
A Case of Verrucous Carcinoma. (nii.ac.jp)

Verrucous carcinoma and giant condyloma of Buschke and Löwenstein are identical lesions. (springer.com)
Results: Our results reveal that the expression of Notch4 was considerably high in oral squamous cell carcinoma lesions compared to normal tissue, whereas in oral verrucous carcinoma, irrespective of the clinicopathological features, complete regula o descendente of Notch4 was observed. (bireme.br)
Cutaneous lesions typically arise in the genitocrural area and plantar surface of the foot, with rare case reports of verrucous carcinoma arising elsewhere on the body. (umassmed.edu)
A single case of basaloid squamous cell carcinoma of the bladder was reported in a 60-year-old woman with incontinence, intractable urinary tract infections (UTIs), and flat, cystoscopic lesions. (medscape.com)
To date, several studies in relatively small cohorts have investigated the role of HPV in verrucous lesions reporting between 0% and 89% of PVL lesions to be HPV positive ( 3 , 5 - 11 ). (aacrjournals.org)
Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions. (naver.com)
Eighteen months later, the polypoid lesions had increased in size, and the biopsy specimen was diagnosed as highly suspicious of well-differentiated squamous cell carcinoma. (springeropen.com)
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon which may, on its own, induce premalignant lesions and carcinomas within a few weeks after it is administered in mucosae [ 4 , 5 ]. (intechopen.com)
Human Papillomavirus (HPV) Profiles of Vulvar Lesions: Possible Implications for the Classification of Vulvar Squamous Cell Carcinoma Precursors and for the Efficacy of Prophylactic HPV Vaccination. (thedoctorsdoctor.com)
To analyze the impact of HPV profiles of vulvar precancerous lesions for their classification and to assess the presumable efficacy of the prophylactic HPV vaccination, 269 vulvar excisions representing lichen sclerosus, lichen simplex chronicus, condylomata acuminata, d-VIN, all grades of u-VIN and squamous cell carcinomas were subjected to the HPV typing by use of GP5+/6+ polymerase chain reaction and reverse line blot hybridization. (thedoctorsdoctor.com)
Depending on the site of involvement, various names have been used in the literature to describe this entity, including Ackerman tumor (solitary oral mucosal lesion), Buschke-Lowenstein tumor (genital involvement), florid oral papillomatosis (multiple oral lesions), and carcinoma cuniculatum (sole of the foot). (mdedge.com)
The critical needs in oral cancer treatment are development of useful approaches to prevention of dysplastic lesions, increased accuracy of diagnosis, and discovery of definitive biological markers for progression of these lesions to carcinomas. (aacrjournals.org)

Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma. (wikipedia.org)
Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. (em-consulte.com)
Esophageal verrucous carcinoma is a rare variant of esophageal squamous cell carcinoma. (unboundmedicine.com)
It is a particular variant of anal and perianal squamous cell carcinoma, characterized by its slow growing, and its tendency to form abscesses and fistulae. (springer.com)
This variant of SCCA is typically less aggressive than other squamous cell carcinomas. (laryngopedia.com)
Esophageal verrucous carcinoma (VC) is a rare variant of esophageal squamous cell carcinoma. (biomedcentral.com)
VC of the esophagus is a rare malignant epithelial tumor representing a variant of squamous cell carcinoma. (biomedcentral.com)
Verrucous squamous cell carcinoma is a rare variant of squamous cell carcinoma of the bladder, accounting for less than 5% of the squamous cell carcinomas. (medscape.com)
Verrucous carcinoma is an unusually well‑differentiated variant of squamous cell carcinoma, characterized by local invasion and cytologically benign appearance. (manipal.edu)
Verrucous carcinoma (VC) was first described as a variant of squamous cell carcinoma by Ackerman in 1948 [ 1 ] and is characterized as a slow growing, well-differentiated, locally spreading tumor. (springeropen.com)
In 1948, Ackerman first described verrucous squamous cell carcinoma (VSC) as a variant of oral squamous cell carcinoma [ 1 ], and he collected 31 cases of oral neoplasms under the name, "Verrucous Carcinoma of the Oral Cavity. (scientificarchives.com)
Verrucous carcinoma (VC) is a locally invasive, nonmetastasising well differentiated variant of squamous cell carcinoma. (elsevier.com)
bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)
Allon D, Kaplan I, Manor R, Calderon S. Carcinoma cuniculatum of the jaw: a rare variant of oral carcinoma. (springer.com)
On the other hand, the verrucous carcinoma, which is considered low-grade variant of squamous cell carcinoma, is unifocal and unlikely to return. (usp.br)
Verrucous carcinoma is a rare variant of squamous cell carcinoma (SCC) with specific clinical and histological features. (mdedge.com)
One variant, called verrucous carcinoma, has a cauliflower appearance. (bellaonline.com)

This randomized phase III trial studies chemotherapy to see how well it works with or without bevacizumab in treating patients with head and neck squamous cell carcinoma that has come back (recurrent) or that has spread to other parts of the body (metastatic). (clinicaltrials.gov)
It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab in treating patients with head and neck squamous cell carcinoma. (clinicaltrials.gov)
Patient Choice of Nonsurgical Treatment Contributes to Disparities in Head and Neck Squamous Cell Carcinoma. (amedeo.com)
Assessing the Impact of Targeting CEACAM1 in Head and Neck Squamous Cell Carcinoma. (amedeo.com)
Effect of Adipose-Derived Stem Cells on Head and Neck Squamous Cell Carcinoma. (amedeo.com)

Verrucous Carcinoma is a diffuse papillary, non metastasizing, well differentiated malignant neoplasm of the oral epithelium. (syriaforums.net)
Primary vaginal carcinoma is rare, constituting only 1-2% of all malignant gynecologic tumors. (medscape.com)
Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the genetic landscape of verrucous carcinomas (VC) is largely uncharted. (biomedcentral.com)
Inverted papillomas are not infrequently associated with malignant tumors, primarily squamous cell carcinoma, and in some instances malignant transformation in an inverted papilloma to carcinoma may be observed. (upmc.edu)
We recently encountered a case in which a malignant tumor was suspected on initial endoscopic evaluation, but two biopsies revealed no carcinoma cells. (elsevier.com)
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
Hürthle cell carcinoma a malignant Hürthle cell tumor . (thefreedictionary.com)

Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis is worse. (wikipedia.org)
Methods: Ten patients reported positive for oral cancer (5 patients with oral verrucous carcinoma and 5 patients with oral squamous cell carcinoma). (bireme.br)
Tissues from patients with oral verrucous carcinoma were examined for the presence of human papillomavirus (HPV). (elsevier.com)

Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus. (naver.com)
Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour? (naver.com)
Although immunoperoxidase stains for human papillomavirus antigens are negative in both components of the tumor mass, inverted papillomas and verrucous carcinomas have been associated with human papillomavirus infection. (upmc.edu)
Human papillomavirus-associated penile squamous cell carcinoma in HIV-positive patients. (cigna.com)
Clinicopathologic features and human papillomavirus dna prevalence of warty and squamous cell carcinoma of the penis. (cigna.com)
The prevailing evidence favors human papillomavirus (HPV) as a causative factor in many genital tract carcinomas. (adventisthealthcare.com)

Squamous carcinoma in situ adjacent to the tumor. (medscape.com)
these include leukemia and most forms of carcinoma in situ . (wikipedia.org)

Verrucous carcinoma of the vulva is a rare lesion ( 1 ). (frontiersin.org)
Squamous cell carcinoma of the vulva progresses through similar stages as squamous cell carcinoma of the cervix and vagina. (thedoctorsdoctor.com)
The majority of the tissue arises from squamous cells and squamous cell carcinoma accounts for 90% of the malignancies of the vulva. (bellaonline.com)
Prognostic factors in carcinoma of the vulva. (adventisthealthcare.com)

Males have predominated, but the proportion of women with VCE (28 males, 18 females, 2 gender unknown) has been higher among esophageal squamous cell carcinoma patients. (scientificarchives.com)
range, 36-79 years) have been similar to those of esophageal squamous cell carcinoma patients. (scientificarchives.com)
Lactate dehydrogenase and baseline markers associated with clinical outcomes of advanced esophageal squamous cell carcinoma patients treated with camrelizumab (SHR-1210), a novel anti-PD-1 antibody. (bioportfolio.com)
Volatile Organic Compounds in the Breath of Oral Squamous Cell Carcinoma Patients: A Pilot Study. (amedeo.com)

List of cutaneous conditions List of verrucous carcinoma subtypes Ridge JA, Glisson BS, Lango MN, et al. (wikipedia.org)
Several subtypes of verrucous carcinoma have been described. (wikipedia.org)

Anal verrucous carcinoma is a very rare tumor and it is difficult to assess its incidence. (springer.com)
The strict criteria used in defining vaginal carcinoma contribute to this low incidence. (medscape.com)
The incidence rate of oral squamous cell carcinoma surrounding implants seems to be higher in patients with previous oral tumors. (isciii.es)

Tokunaga M, Uto H, Oda K, Mawatari S, Kumagai K, Haraguchi K. Influence of human T-lymphotropic virus type 1 coinfection on the development of hepatocellular carcinoma in patients with hepatitis C virus infection. (univalle.edu.co)
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles , consisting of two layers of cells surrounding a minute lumen. (thefreedictionary.com)
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. (thefreedictionary.com)
According to randomized controlled trial requirement, the therapeutic effectiveness of cooled-probe microwave ablation and radiofrequency ablation on early-stage hepatocellular carcinoma i. (bioportfolio.com)
Hepatocellular carcinoma is the third most common cause of cancer-related mortality. (bioportfolio.com)
This study was designed to evaluate the effectiveness of radiofrequency /microwave ablation in patients with hepatocellular carcinoma beyond Milan Criteria. (bioportfolio.com)
Liver resection for recurrent hepatocellular carcinoma after radiofrequency ablation therapy. (bioportfolio.com)
Although radiofrequency ablation (RFA) is an effective local treatment of hepatocellular carcinoma (HCC), local recurrence is relatively frequent. (bioportfolio.com)
Open Liver Resection, Laparoscopic Liver Resection, and Percutaneous Thermal Ablation for Patients with Solitary Small Hepatocellular Carcinoma (≤30 mm): Review of the Literature and Proposal for a Therapeutic Strategy. (bioportfolio.com)
Patients with a single hepatocellular carcinoma (HCC) ≤3 cm and preserved liver function have the highest likelihood to be cured if treated. (bioportfolio.com)
Validity of the Iwate criteria for patients with hepatocellular carcinoma undergoing minimally invasive liver resection. (bioportfolio.com)
Multiple antenna placement in microwave ablation assisted by a three-dimensional fusion image navigation system for hepatocellular carcinoma. (bioportfolio.com)
Improved survival of splenectomy combined with curative treatments for hepatocellular carcinoma in Child B patients: a propensity score matching study. (bioportfolio.com)
To explore the benefits of curative treatments (liver resection or local ablation) combined with splenectomy for patients with hepatocellular carcinoma (HCC) and Child grade B liver function. (bioportfolio.com)
An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. (bioportfolio.com)
It was first cloned from an erythropoietin-producing human hepatocellular carcinoma cell line and is highly conserved among many mammalian species. (bioportfolio.com)

Clinical: Rare, accounts ~4% of penile carcinoma. (auanet.org)
Verrucous carcinoma of the oral cavity: a clinical and pathological study of 101 cases," Oral Oncology , vol. 45, no. 1, pp. 47-51, 2009. (hindawi.com)
GlobalData's clinical trial report, "Verrucous Carcinoma Global Clinical Trials Review, H2, 2016" provides an overview of Verrucous Carcinoma clinical trials scenario. (giiresearch.com)
This report provides top line data relating to the clinical trials on Verrucous Carcinoma. (giiresearch.com)
Due to high index of suspicion of verrucous carcinoma on clinical presentation and imaging, patient underwent a composite resection with posterior segmental mandibulectomy and selective neck node dissection of ipsilateral side. (minervamedica.it)
We here describe the clinical course of a PHTS patient who, in addition to a typical thyroid carcinoma at the age of 36 years, developed a highly-differentiated oral VC and an epithelioid MPM six years later. (biomedcentral.com)
Clinical outcomes of locally advanced esophageal neuroendocrine carcinoma treated with chemoradiotherapy. (bioportfolio.com)
Clinical tools are unavailable for accurately predicting the pathological responses to chemoradiotherapy (CRT) of patients with esophageal squamous cell carcinoma (ESCC) before surgery. (bioportfolio.com)
Padilla RJ, Murrach VA. Carcinoma cuniculatum of the oral mucosa: a potentially underdiagnosed entity in the absence of clinical correlation. (springer.com)
Due to clinical and histological findings, a diagnosis of verrucous carcinoma (VC) was made. (mdedge.com)

It does not metastasize, although it may develop foci of invasive squamous cell carcinoma. (medscape.com)
VIN is found adjacent to 60-80% of superficially invasive squamous cell carcinomas and 25% of deeply invasive carcinomas. (thedoctorsdoctor.com)

The diagnosis of verrucous carcinoma is often not easy because its histopathology mimics verruca vulgaris and other benign diseases. (elsevier.com)

It is important to note that the recurrence of verrucous carcinoma announces a bad prognosis ( 6 ). (frontiersin.org)

The salivary glands are susceptible to several oral cavity cancers, including adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and mucoepidermoid carcinoma. (newhopemedicalcenter.com)
Called also alveolar carcinoma or adenocarcinoma and bronchiolar , bronchioloalveolar , or bronchoalveolar adenocarcinoma . (thefreedictionary.com)
adenocarcinoma of the lung , large cell carcinoma , small cell carcinoma , and squamous cell carcinoma . (thefreedictionary.com)
Squamous cell carcinoma is the most common histology in Eastern Europe and Asia, and adenocarcinoma is most common in N. (bioportfolio.com)
Types of minor salivary gland tumours include adenocarcinoma, adenoid cystic carcinoma and mucoepidermoid carcinoma. (cancer.ca)
The common types of cancer from these cells include melanoma, sarcoma, basal cell carcinoma, adenocarcinoma and Bartholin s gland carcinoma. (bellaonline.com)

Verrucous carcinomas are rare, well-differentiated squamous cell carcinomas that in most cases seem to be confined to the basal membrane, but invasive growth and loco-regional metastases have also been described [ 7 ]. (ersjournals.com)
Basal cell carcinoma. (oncolink.org)
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells , rarely metastatic but locally invasive and aggressive. (thefreedictionary.com)
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements. (thefreedictionary.com)
A marcação mostrou-se escassa, mas evidente em células mitóticas da leucoplasia verrucosa proliferativa, mostrando, no entanto, maior número de células positivas no carcinoma verrucoso, estas visíveis nas camadas basal e parabasal. (usp.br)
Background: Basal cell and squamous cell carcinomas both arise in the epidermis of fair-skinned people in response to ultraviolet light, with the overall frequency of basal cell carcinoma being 4 times that of squamous cell carcinoma. (jddonline.com)
Objective: The study explores whether or not there is a pattern of expression of basal versus squamous cell carcinoma among people with these cancers. (jddonline.com)

Objective: In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. (bireme.br)
5 percent of mouth tumors are verrucous carcinoma or "snuff dipper's cancer," a slow-progressing disease comprising squamous cells. (newhopemedicalcenter.com)

Histopathological variants of cutaneous squamous cell carcinoma a review. (univalle.edu.co)
At Moffitt Cancer Center, we diagnose and treat a complete range of skin cancers, including the unique variants of squamous cell carcinoma. (moffitt.org)
Carcinoma cuniculatum is one of the variants of squamous cell carcinoma. (springer.com)
1% compared to other histological variants of squamous cell carcinoma. (springer.com)

Most patients with verrucous carcinoma have a good prognosis. (wikipedia.org)
The prognosis of locally advanced esophageal squamous cell carcinoma is poor,the role of chemotherapy as neoadjuvant therapy in locally advanced esophageal cancer has been established, whi. (bioportfolio.com)

Hassan, M , Qureshi, A & Nasir, H 2016, ' Recurrent verrucous carcinoma of the urinary bladder after transurethral resection followed by intravesical mitomycin, and a review of the literature ', BMJ Case Reports , vol. 2016, 216146. (elsevier.com)

Verrucous carcinoma is an extremely rare form of cancer in the esophagus. (springeropen.com)
We used the keywords "esophagus" and "verrucous carcinoma" to search the literature in the PubMed database during the period from 1983 to 2018 ( Table 1 ). (scientificarchives.com)
Verrucous carcinoma of the esophagus (VCE) is a rare, slow-growing, well-differentiated squamous cell carcinoma. (elsevier.com)

Fingerprint Dive into the research topics of 'Aberrant β-catenin expression in the histologic differentiation of oral squamous cell carcinoma and verrucous carcinoma: an immunohistochemical study. (elsevier.com)
Sun Y, Kuyama K, Burkhardt A, Yamamoto H. An immunohistochemical study of oral carcinoma cuniculatum. (springer.com)

Over 90 percent of cancers in the mouth and oropharynx are squamous cell carcinoma. (newhopemedicalcenter.com)
Barnes L, Eveson JW, Reichart P, Sidransky D. Tumours of the oral cavity and oropharynx: squamous cell carcinoma. (springer.com)
2 Verrucous carcinoma typically occurs in 1 of 3 locations: the oropharynx, genitals, or soles of the feet. (mdedge.com)

Verrucous carcinoma, left vocal cord, persistent after radiotherapy elsewhere, in a patient unable to undergo general anesthesia due to severe lung disease. (laryngopedia.com)
Is primary radiotherapy an appropriate option for the treatment of verrucous carcinoma of the head and neck? (naver.com)
1968-2005) PMID 19330296 -- "Long-term results of radiotherapy in primary carcinoma of the vagina. (wikibooks.org)
2003 PMID 12829129 -- "High-dose-rate (HDR) brachytherapy with or without external beam radiotherapy in the treatment of primary vaginal carcinoma: long-term results and side effects. (wikibooks.org)

We must consider that verrucous carcinoma can manifest as appearance of a polyp that is not papillary or warty-like with and without extensive superficial growth appearance. (unboundmedicine.com)
Warty carcinoma (verruciform). (cigna.com)
About 75% to 100% of basaloid and warty carcinomas harbor HPV infection. (cigna.com)

Cancers from distant sites that metastasize to the vagina through the blood or lymphatic system also occur, including colon cancer, renal cell carcinoma, melanoma , and breast cancer. (medscape.com)

An endoscopic submucosal dissection was performed and the histopathological findings showed a well-differentiated squamous cell carcinoma with hyperkeratosis with a church spire configuration. (unboundmedicine.com)
b High-magnification image shows well-differentiated squamous cell carcinoma and focal hyperkeratosis with a church spire configuration (H&E, original magnification, ×400). (biomedcentral.com)

Macroscopic examination of the resected specimen showed a white protruding lesion with an irregular surface, and histopathological examination led to a diagnosis of esophageal verrucous carcinoma without lymph node metastasis. (springeropen.com)
Management of Sentinel Lymph Node Metastasis in Merkel Cell Carcinoma: Completion Lymphadenectomy, Radiation, or Both? (moffitt.org)
Tumor Metabolism in the Microenvironment of Nodal Metastasis in Oral Squamous Cell Carcinoma. (amedeo.com)

In most cases, verrucous carcinoma presents as an exophytic, slow-growing mass with an extensive superficial growth pattern. (unboundmedicine.com)
It presented as an exophytic growth in mandibular alveolar region, with histological features consistent with carcinoma cuniculatum. (springer.com)

adenocystic carcinoma ( adenoid cystic carcinoma ) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. (thefreedictionary.com)

Cancer 1998;83:204-12 Saranath D, Chang SE, Bhotie LT, Panchal RG, Kerr IB, Mehta AR, Johnson NW, Deo MG. High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. (wikipedia.org)
The verrucous carcinoma is an uncommon lesion in the vulvar cancer classification. (frontiersin.org)
[ 3 ] Worldwide, however, squamous cell carcinoma is the most common form of bladder cancer, accounting for up to 73% of cases in developing nations, particularly regions with a high prevalence of schistosomiasis (eg, Middle East, Southeast Asia, South America). (medscape.com)
For more information, see Bladder Cancer , as well as Pathologic Findings in Small Cell Bladder Carcinoma and Cystoscopy . (medscape.com)
According to the American Cancer Society, about 51,540 people were expected to receive a diagnosis of oral or oropharyngeal carcinoma (throat cancer) in 2018. (newhopemedicalcenter.com)
Squamous cell carcinoma is a type of skin cancer that accounts for about 90% of vulvar cancers, most of which are found on the labia. (cancer.net)
The most common type of penile cancer is squamous cell carcinoma. (oncolink.org)
A form of cancer , carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. (thefreedictionary.com)
The most common type of hypopharyngeal cancer is squamous cell carcinoma (SCC). (cancer.ca)
The spectrum of HPV types found in vulvar squamous cell carcinomas indicates that the efficacy of HPV vaccination in preventing vulvar cancer might be diminished in the studied population, because the recently developed prophylactic vaccines are targeted against a limited number of HPV types. (thedoctorsdoctor.com)
Typically when the term vulvar cancer is used, it is referring to these squamous cell carcinomas. (bellaonline.com)
Carcinoma means cancer. (cancerresearchuk.org)
Squamous cell carcinoma is cancer starting in the squamous cells. (cancerresearchuk.org)

Anal verrucous carcinoma, also known as anal Buschke-Löwenstein tumor, is a rare neoplasm. (jamanetwork.com)
1 We report a case of anal verrucous carcinoma containing human papilloma virus (HPV) type 11 DNA in an episomal form. (jamanetwork.com)
Zemtsov A, Koss W, Dixon L, Tyring S, Rady P. Anal Verrucous Carcinoma Associated With Human Papilloma Virus Type 11: Magnetic Resonance Imaging and Flow Cytometry Evaluation. (jamanetwork.com)
HPV-16-positive anal and penile carcinomas in a young man--anogenital 'field effect' in the immunosuppressed male? (cigna.com)

In oral squamous cell carcinoma, the number of β-catenin-positive cases and the intensity of expression decreased as cancers became more poorly differentiated. (manipal.edu)
The limited body of data on the topic, however, suggests that the pathogenesis of PVL-associated carcinomas is distinctive from non-PVL-associated cancers. (aacrjournals.org)
Like most cancers, the exact cause of oral carcinoma is not clear. (newhopemedicalcenter.com)
More than 90% of invasive vulvar cancers are squamous cell carcinomas. (cigna.com)
More than 90 out of 100 (90%) mouth and oropharyngeal cancers are squamous cell carcinomas. (cancerresearchuk.org)

Low-magnification micrograph of penile verrucous carcinoma. (wikipedia.org)
Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases. (cigna.com)

The mass was diagnosed as verrucous carcinoma on histopathological examination. (oalib.com)

Because verrucous carcinoma and ILVEN can have striking histologic similarities, one expert recommends considering verrucous carcinoma in the differential diagnosis of ILVEN. (dermatologytimes.com)
The case furthermore suggests that physicians consider verrucous carcinoma in the differential diagnosis of ILVEN, he adds. (dermatologytimes.com)
ILVEN has never before entered into the histologic differential diagnosis of a verrucous carcinoma. (dermatologytimes.com)

Basaloid carcinoma. (cigna.com)

Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinoma related to tobacco use. (wikipedia.org)
Datar UV, Kale A, Mane D. Oral carcinoma cuniculatum: a new entity in the clinicopathological spectrum of oral squamous cell carcinoma. (springer.com)
Oral carcinoma cuniculatum: two cases illustrative of a diagnostic challenge. (springer.com)

Epithelioma cuniculatum (also known as Carcinoma cuniculatum, and Ackerman tumor) is a subtype of verrucous carcinoma, characterized by well-differentiated epithelial cells which lack cytological atypia, but display a blunt papillary/pebbly surface and keratin-filled crypts extending deep into the connective tissue. (wikipedia.org)
medullary carcinoma that composed mainly of epithelial elements with little or no stroma. (thefreedictionary.com)

The most common non-squamous laryngeal carcinoma is neuroendocrine carcinoma. (springer.com)
In addition, neuroendocrine carcinomas can also be seen. (cigna.com)

Radiofrequency ablation is a treatment option for early stages of verrucous esophageal carcinoma. (uniklinik-freiburg.de)

Verrucous carcinoma may occur in various head and neck locations, as well as in the genitalia or sole of the foot. (wikipedia.org)
Int J Oral Surg 1985;14:485-92 Koch BB, Trask DK, Hoffman HT, Karnell LH, Robinson RA, Zhen W, Menck HR. National survey of head and neck verrucous carcinoma. (wikipedia.org)
A national survey of head and neck verrucous carcinomas also reported oral verrucous carcinoma to be more common in elderly females compared with males ( 7 ). (aacrjournals.org)
Papillary squamous cell carcinoma versus verrucous squamous cell carcinoma of the head and neck. (naver.com)
Capecitabine after Surgical Salvage in Recurrent Squamous Cell Carcinoma of Head and Neck. (amedeo.com)
Is Perineural Invasion of Head and Neck Squamous Cell Carcinomas Linked to Tobacco Consumption? (amedeo.com)
I. To find a safe and tolerable interleukin (IL)-12 (recombinant interleukin-12) dose for use in combination with cetuximab in patients with unresectable primary or recurrent squamous cell carcinoma of the head and neck. (knowcancer.com)

After applying various carcinogens, including 9,10-dimethyl-1,2 benzanthracene on the oral epithelium of Syrian hamsters for 3 months, Salley was able to verify the existence of squamous cell carcinomas (SCC) and lymphatic metastases. (intechopen.com)

The excised specimens proved to be superficially invasive verrucous carcinoma, he says. (dermatologytimes.com)
Squamous cell carcinomas have been divided into a superficially invasive type and invasive type. (thedoctorsdoctor.com)

Although primary vaginal carcinoma is a rare gynecologic malignancy, its impact on women's health should not be underestimated, especially when considering the demographic increase in elderly women. (medscape.com)
To improve outcomes of primary vaginal carcinoma, select referral oncology centers should see additional cases per month in order to plan appropriate randomized, prospective studies. (medscape.com)
This would increase the experience of any of these centers in treating primary vaginal carcinoma. (medscape.com)

There is only one case report about a squamous cell carcinoma in a solitary papilloma [ 8 ]. (ersjournals.com)
Sections demonstrate two distinct histologic neoplasms: an inverted papilloma and a coexisting verrucous carcinoma. (upmc.edu)
In this case, there is no transitional zone in the sections examined to suggest that the verrucous carcinoma is arising directly from the inverted papilloma. (upmc.edu)

Squamous cell carcinoma which combined humoral hypercalcemia of malignancy. (nii.ac.jp)

As verrucous carcinomas mostly only show low-grade dysplasia and focal invasion with an otherwise benign appearance, diagnosis based on biopsies is difficult or even impossible [ 5 , 9 ]. (ersjournals.com)

This is a slow-growing subtype of squamous cell carcinoma that looks like a wart. (cancer.net)

Anatomy15

Organisms3

Diseases112

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes28

Disciplines and Occupations1

Information Science5

Health Care16

Verrucous carcinoma of the female breast. (1/43)

Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions. (2/43)

Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. (3/43)

Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma. (4/43)

Invasive cutaneous verruco-cystic squamous cell carcinoma. A pattern commonly present in transplant recipients. (5/43)

Surgical treatment of oral verrucous carcinoma. (6/43)

Verrucous carcinoma of the bladder with koilocytosis unassociated with vesical schistosomiasis. (7/43)

Association of laryngeal cancer with previous gastric resection. (8/43)

Carcinoma

Carcinoma, Squamous Cell

Carcinoma, Hepatocellular

Carcinoma in Situ

Carcinoma, Papillary

Liver Neoplasms

Carcinoma, Ductal, Breast

Carcinoma, Basal Cell

Immunohistochemistry

Carcinoma, Transitional Cell

Carcinoma, Bronchogenic

Carcinoma, Intraductal, Noninfiltrating

Carcinoma, Adenoid Cystic

Carcinoma, Small Cell

Tumor Markers, Biological

Carcinoma, Medullary

Adenocarcinoma

Carcinoma, Lobular

Carcinoma, Neuroendocrine

Neoplasm Invasiveness

Nasopharyngeal Neoplasms

Cell Line, Tumor

Prognosis

Thyroid Neoplasms

Breast Neoplasms

Neoplasm Staging

Gene Expression Regulation, Neoplastic

Tumor Cells, Cultured

Lung Neoplasms

Carcinoma, Mucoepidermoid

Carcinoma, Adenosquamous

Carcinoma, Endometrioid

Head and Neck Neoplasms

Carcinoma, Embryonal

Esophageal Neoplasms

Mouth Neoplasms

Carcinoma, Merkel Cell

Carcinoma, Ductal

Lymphatic Metastasis

Ovarian Neoplasms

Adrenocortical Carcinoma

Colonic Neoplasms

Carcinoma, Verrucous

Carcinoma, Signet Ring Cell

Neoplasm Metastasis

Urinary Bladder Neoplasms

Stomach Neoplasms

Neoplasm Proteins

Skin Neoplasms

Neoplasm Recurrence, Local

Mice, Nude

Carcinoma, Large Cell

DNA, Neoplasm

Laryngeal Neoplasms

Antineoplastic Agents

Retrospective Studies

Uterine Cervical Neoplasms

Immunoenzyme Techniques

RNA, Messenger

Neoplasm Transplantation

Neoplasms, Multiple Primary

Survival Rate

Adenocarcinoma, Follicular

Survival Analysis

Adenocarcinoma, Mucinous

Treatment Outcome

Antigens, Neoplasm

Embryonal Carcinoma Stem Cells

Reverse Transcriptase Polymerase Chain Reaction

Precancerous Conditions

Carcinoma, Papillary, Follicular

Gallbladder Neoplasms

Carcinoma, Non-Small-Cell Lung

Tumor Suppressor Protein p53

Endometrial Neoplasms

Adenocarcinoma, Clear Cell

Disease Progression

Colorectal Neoplasms

Cell Proliferation

alpha-Fetoproteins