A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Tumors or cancer of the MOUTH.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
Tumors or cancer of the ESOPHAGUS.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the SKIN.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Tumors or cancer of the TONGUE.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A malignant epithelial tumor with a glandular organization.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tumors or cancer of the LUNG.
Tumors or cancer of the LIVER.
A cell line derived from cultured tumor cells.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the OROPHARYNX.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tumors or cancer of the UTERINE CERVIX.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the VULVA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Tumors or cancer of the NASOPHARYNX.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Tumors or cancer of the HYPOPHARYNX.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Tumors or cancer of the PHARYNX.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
DNA present in neoplastic tissue.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumors or cancer of the human BREAST.
Tumors or cancer of the THYROID GLAND.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of the PALATINE TONSIL.
A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
Tumors or cancer of the STOMACH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Tumors or cancer of the ANAL CANAL.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Tumors or cancer of the URINARY BLADDER.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the LIP.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the COLON.
A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Any horny growth such as a wart or callus.
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Tumors or cancer of the BRONCHI.
A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.
Elements of limited time intervals, contributing to particular results or situations.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Cancers or tumors of the PENIS or of its component tissues.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
RNA present in neoplastic tissue.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Transplantation between animals of different species.
A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)
Antibodies produced by a single clone of cells.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Treatment that combines chemotherapy with radiotherapy.
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.
Tumors of cancer of the EYELIDS.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Tumors or cancer of the gallbladder.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A general concept for tumors or cancer of any part of the EAR; the NOSE; the THROAT; and the PHARYNX. It is used when there is no specific heading.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
Total or partial excision of the larynx.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Tumors or cancer of the SALIVARY GLANDS.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the CONJUNCTIVA.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Tumors or cancer of the PARANASAL SINUSES.
A genus of DNA viruses in the family PAPILLOMAVIRIDAE. They preferentially infect the anogenital and ORAL MUCOSA in humans and primates, causing both malignant and benign neoplasms. Cutaneous lesions are also seen.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Inhaling and exhaling the smoke of burning TOBACCO.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Biochemical identification of mutational changes in a nucleotide sequence.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A type I keratin found associated with KERATIN-7 in ductal epithelia and gastrointestinal epithelia.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.

Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. (1/13224)

AIM: To investigate the immunocytochemical staining pattern of mdm2 and p21WAF1 proteins in invasive cervical cancer and to determine its relation with the expression of p53 and with the high risk HPV infection. METHODS: Immunocytochemistry for p53, mdm2, and p21WAF1 was performed in 31 paraffin embedded sections of invasive cervical cancer. The results were assessed by image analysis, evaluating for each protein the optical density of the immunostained area, scored as percentage of the total nuclear area. The presence of high risk human papillomavirus (HPV) infection was detected by using the polymerase chain reaction. RESULTS: Immunostaining for both mdm2 and p21WAF1 was correlated with p53 expression; however, the correlation between p53 and mdm2 (R = 0.49; p < 0.01) was more significant than between p53 and p21WAF1 (R = 0.31; p < 0.05); the less stringent correlation between p53 and p21WAF1 might reflect the p53 independent mechanisms of p21WAF1 induction. Similar average levels of p53, mdm2, and p21WAF1 immunostaining were found in the presence or absence of high risk HPV-DNA, without significant differences between the two groups. CONCLUSIONS: These data suggest that mdm2 and p21WAF1 proteins are expressed in invasive cervical cancer and that their immunocytochemical staining pattern is not abrogated by the presence of high risk HPV genomic sequences.  (+info)

Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. (2/13224)

AIMS: To correlate vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma with the clinicopathological characteristics and prognosis; and to assess whether p53 gene status is associated with VEGF expression in human cancers. METHODS: Tumour specimens from 45 patients with oral squamous cell carcinomas were examined. Expression of VEGF was determined using an immunohistochemical method, and a tumour was considered positive when more than 5% of the neoplastic cells showed VEGF immunoreactivity. The p53 gene status was screened using a polymerase chain reaction--single strand conformation polymorphism analysis. RESULTS: VEGF positive staining was detected in 19 (42.2%) of the 45 cases. VEGF immunoreactivity did not correlate with the histological degree of tumour differentiation, clinical stages, or lymph node metastasis. The patients with VEGF positive tumours had a significantly worse prognosis than those with VEGF negative tumours. The five year overall survival rate of the VEGF negative patients was 76.5%, as compared with 48.8% for the VEGF positive patients. No significant association between VEGF expression and the p53 gene status of the tumours was found. CONCLUSIONS: VEGF is a good prognostic indicator of the survival of patients with oral squamous cell carcinoma. The p53 gene status does not seem to be associated with VEGF expression in these cancers.  (+info)

Expression of extracellular matrix proteins in cervical squamous cell carcinoma--a clinicopathological study. (3/13224)

AIM: To evaluate the intracellular and peritumoral expression of matrix proteins in squamous cell carcinoma of the uterine cervix using immunohistochemistry. METHODS: 71 squamous cell carcinomas and 10 controls were stained for laminin, fibronectin, and collagen IV. Cytoplasmic staining in tumour cells and peritumoral deposition of matrix proteins were evaluated. The association between staining results and patient age, tumour stage, histological grade, and survival was studied. RESULTS: Positive cytoplasmic staining for laminin, fibronectin, and collagen IV was observed in 17 (23.9%), 27 (38%), and 10 (14.1%) cases, respectively. Staining for laminin was most pronounced in the invasive front of tumour islands, while for fibronectin and collagen IV it appeared to be diffuse. Peritumoral staining for laminin and collagen IV was detected in 12 cases (16.9%). Early stage (Ia1-Ia2) tumours were uniformly negative for all three proteins. Cytoplasmic staining for laminin correlated with positive staining for fibronectin and collagen IV, and with the presence of a peritumoral deposition of collagen IV and laminin. There was no correlation with any of the three markers between staining results and patient age, stage, grade, or survival. CONCLUSIONS: Expression of extracellular matrix proteins in some cervical squamous cell carcinomas might reflect the enhanced ability of these tumours to modify the peritumoral stroma. This ability seems to be absent in early stage tumours. The correlation between intracytoplasmic and peritumoral expression of matrix proteins supports the evidence of their synthesis by tumour cells. However, this property did not correlate with disease outcome in this study.  (+info)

Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus. (4/13224)

Human UDP-glucuronosyltransferases (UGTs) are expressed in a tissue-specific fashion in hepatic and extrahepatic tissues [Strassburg, Manns and Tukey (1998) J. Biol. Chem. 273, 8719-8726]. Previous work suggests that these enzymes play a protective role in chemical carcinogenesis [Strassburg, Manns and Tukey (1997) Cancer Res. 57, 2979-2985]. In this study, UGT1 and UGT2 gene expression was investigated in human oesophageal epithelium and squamous-cell carcinoma in addition to the characterization of individual UGT isoforms using recombinant protein. UGT mRNA expression was characterized by duplex reverse transcriptase-PCR analysis and revealed the expression of UGT1A7, UGT1A8, UGT1A9 and UGT1A10 mRNAs. UGT1A1, UGT1A3, UGT1A4, UGT1A5 and UGT1A6 transcripts were not detected. UGT2 expression included UGT2B7, UGT2B10 and UGT2B15, but UGT2B4 mRNA was absent. UGT2 mRNA was present at significantly lower levels than UGT1 transcripts. This observation was in agreement with the analysis of catalytic activities in oesophageal microsomal protein, which was characterized by high glucuronidation rates for phenolic xenobiotics, all of which are classical UGT1 substrates. Whereas UGT1A9 was not regulated, differential regulation of UGT1A7 and UGT1A10 mRNA was observed between normal oesophageal epithelium and squamous-cell carcinoma. Expression and analysis in vitro of recombinant UGT1A7, UGT1A9, UGT1A10, UGT2B7 and UGT2B15 demonstrated that UGT1A7, UGT1A9 and UGT1A10 catalysed the glucuronidation of 7-hydroxybenzo(alpha)pyrene, as well as other environmental carcinogens, such as 2-hydroxyamino-1-methyl-6-phenylimidazo-(4, 5-beta)-pyridine. Although UGT1A9 was not regulated in the carcinoma tissue, the five-fold reduction in 7-hydroxybenzo(alpha)pyrene glucuronidation could be attributed to regulation of UGT1A7 and UGT1A10. These data elucidate an individual regulation of human UGT1A and UGT2B genes in human oesophagus and provide evidence for specific catalytic activities of individual human UGT isoforms towards environmental carcinogens that have been implicated in cellular carcinogenesis.  (+info)

Syndecan-1 expression has prognostic significance in head and neck carcinoma. (5/13224)

The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of syndecan-1 expression in squamous cell carcinoma (SCC) of the head and neck treated with surgery and post-operative radiotherapy. Paraffin-embedded tissue samples taken from 175 patients with primary SCC, followed up from 2 to 15 years after surgery, were studied for expression of syndecan-1 by immunohistochemistry. A low number (< or =50%, the median value) of syndecan-1-positive tumour cells was associated with low histological grade of differentiation (P<0.0001), a large primary tumour size (T1-2 vs. T3-4, P = 0.02), positive nodal status (NO vs. N1-3, P = 0.0006), and high clinical stage (stage I or II vs. III or IV, P<0.0001). Low syndecan-1 expression was also associated with unfavourable overall survival in a univariate analysis (P = 0.001). In a multivariate survival analysis, the clinical stage and syndecan-1 expression were the only independent prognostic factors. We conclude that syndecan-1 is a novel prognostic factor in SCC of the head and neck treated with surgery and post-operative radiotherapy.  (+info)

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. (6/13224)

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5-7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer.  (+info)

Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas. (7/13224)

Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by invading tumor cells in squamous cell carcinomas (SCCs) of the head and neck. Here, we have further elucidated the role of MMP-13 in tumor invasion by examining its expression in invasive malignant tumors of the female genital tract. Using in situ hybridization, expression of MMP-13 mRNA was detected in 9 of 12 vulvar SCCs, primarily in tumor cells, but not in intact vulvar epithelium, in cervical SCCs (n = 12), or in endometrial (n = 11) or ovarian adenocarcinomas (n = 8). MMP-13 expression was especially abundant in vulvar carcinomas showing metastasis to lymph nodes and was associated with expression of membrane type 1 MMP by tumor cells and gelatinase-A (MMP-2) by stromal cells, as detected by immunohistochemistry. MMP-13 mRNAs were detected in 9 of 11 cell lines established from vulvar carcinomas and in 4 of 6 cell lines from cervical carcinomas, whereas endometrial (n = 10) and ovarian (n = 9) carcinoma cell lines were negative for MMP-13 mRNA. No correlation was detected between MMP-13 expression and p53 gene mutations in vulvar SCC cell lines. However, MMP-13 expression was detected in 5 of 6 vulvar and cervical SCC cell lines harboring HPV 16 or 68 DNA. These results show that MMP-13 is specifically expressed by malignantly transformed squamous epithelial cells, including vulvar SCC cells, and appears to serve as a marker for their invasive capacity.  (+info)

[3H]gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. (8/13224)

Cellular uptake of many chemotherapeutic nucleoside analogs is dependent on the activity of a family of nucleoside transport proteins located in the cell plasma membrane. In the present study, we examined the role of these transporters in the accumulation of gemcitabine by a human head and neck squamous carcinoma cell line. The uptake of [3H]gemcitibine was compared with that of [3H]uridine and [3H]formycin B in the parent cell line (HN-5a) and in a gemcitabine-resistant variant (GEM-8e). The HN-5a and GEM-8e cells were similar in their transport characteristics and expressed predominantly the es (equilibrative, inhibitor-sensitive) transporter subtype; less than 10% of the influx of [3H]formycin B or [3H]uridine was mediated by the ei (equilibrative inhibitor-resistant) system, and there was no evidence for Na+-dependent nucleoside transporters. [3H]Gemcitabine (10 microM) entered these cells via both the es and ei transporters with an initial rate of uptake similar to that seen with the use of [3H]formycin B or [3H]uridine. In addition, ATP-replete cells accumulated significantly less [3H]gemcitabine than did ATP-depleted cells, which is indicative of an active efflux mechanism for gemcitabine. These results show that gemcitabine is a substrate for both the es and ei nucleoside transporters of HN-5a and GEM-8e cells and that gemcitabine resistance of the GEM-8e cells cannot be attributed to changes in transporter activity. Further studies to define the characteristics of the putative efflux mechanism are clearly warranted because this system has the potential to significantly affect the clinical efficacy of gemcitabine.  (+info)

Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal ...
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Nasopharynx Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage III Salivary Gland Cancer Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal ...
plus cbd oil spray For Squamous Cell Carcinoma, cbd oil spray cv sciences For Squamous Cell Carcinoma, plus cbd oil spray review For Squamous Cell Carcinoma, extra strength pluscbd oil spray For Squamous Cell Carcinoma, cbd oil spray For Squamous Cell Carcinoma, cbd oil spray peppermint 2 oz 500mg cbd For Squamous Cell Carcinoma, herbal renewals cbd oil spray For Squamous Cell Carcinoma, cbd hemp oil spray For Squamous Cell Carcinoma, spray lingual cbd cure oil extract 30ml For Squamous Cell Carcinoma, cbd oil spray for sale For Squamous Cell Carcinoma, cbd oil spray amazon For Squamous Cell Carcinoma, cbd oil spray dosage For Squamous Cell Carcinoma, cbd oil spray juice For Squamous Cell Carcinoma, cbd cure oil extract spray For Squamous Cell Carcinoma, plus cbd oil cbd spray tincture For Squamous Cell Carcinoma, how to use cbd oil spray For Squamous Cell Carcinoma, cbd oil spray jobs For Squamous Cell Carcinoma, cbd oil spray review For Squamous Cell Carcinoma, cbd oil spray for dogs
plus cbd oil spray For Squamous Cell Carcinoma, cbd oil spray cv sciences For Squamous Cell Carcinoma, plus cbd oil spray review For Squamous Cell Carcinoma, extra strength pluscbd oil spray For Squamous Cell Carcinoma, cbd oil spray For Squamous Cell Carcinoma, cbd oil spray peppermint 2 oz 500mg cbd For Squamous Cell Carcinoma, herbal renewals cbd oil spray For Squamous Cell Carcinoma, cbd hemp oil spray For Squamous Cell Carcinoma, spray lingual cbd cure oil extract 30ml For Squamous Cell Carcinoma, cbd oil spray for sale For Squamous Cell Carcinoma, cbd oil spray amazon For Squamous Cell Carcinoma, cbd oil spray dosage For Squamous Cell Carcinoma, cbd oil spray juice For Squamous Cell Carcinoma, cbd cure oil extract spray For Squamous Cell Carcinoma, plus cbd oil cbd spray tincture For Squamous Cell Carcinoma, how to use cbd oil spray For Squamous Cell Carcinoma, cbd oil spray jobs For Squamous Cell Carcinoma, cbd oil spray review For Squamous Cell Carcinoma, cbd oil spray for dogs
Head and neck cancer, including oral squamous cell carcinoma, is the sixth most common cancer worldwide. Although cancer cell invasion and metastasis are crucial for tumor progression, detailed molecular mechanisms underlying the invasion and metastasis of oral squamous cell carcinoma are unclear. Comparison of transcriptional profiles using a cDNA microarray demonstrated that N4BP2L1, a novel oncogene expressed by neural precursor cells, is involved in oral squamous cell carcinoma. Expression of N4BP2L1 in oral squamous cell carcinoma is regulated by activation of miR-448 and is higher than in normal oral mucosa. Knockdown of N4BP2L1 and upregulation of miR-448 significantly reduced the invasive potential of oral squamous cell carcinoma cells. We studied N4BP2L1 expression in 187 cases of oral squamous cell carcinoma and found its overexpression to be significantly associated with nodal metastasis (P = 0.0155) and poor prognosis (P = 0.0136). Expression of miR-448 was found to be inversely associated
Cutaneous Squamous cell Carcinoma (CsCC) - Epidemiology Forecast To 2025 provides an overview of the epidemiology trends of Cutaneous Squamous cell Carcinoma (CsCC) in seven major markets (US, France, Germany, Italy, Spain, UK and Japan). It includes 10 years epidemiology historical and forecasted data of Cutaneous Squamous cell Carcinoma (CsCC) prevalent or incident cases segmented by age, sex and subpopulations. The Report also discusses the prevailing risk factors, disease burden with special emphasis on the unmet medical need associated with the Cutaneous Squamous cell Carcinoma (CsCC). The report is built using data and information sourced from proprietary databases, primary and secondary research and in-house Forecast model analysis by team of industry experts.. The report will help in developing business strategies by understanding the trends shaping and driving the global Cutaneous Squamous cell Carcinoma (CsCC) market. It helps in identifying prevalent patient populations as well as ...
Abstract: ABSTRACT Although many mouse models of lung adenocarcinoma exist, there is no mouse lung squamous cell carcinoma model that has been validated for use in preclinical lung cancer chemoprevention studies. Since most clinical chemoprevention trials of lung cancer are performed in subjects with bronchial dysplasia, development of a lung squamous cell carcinoma mouse model becomes one of the highest priorities. We have shown that lung squamous cell carcinomas can be induced chemically in several strains of mice (Wang et al. 2004) and that green tea polyphenols exhibit a significant efficacy against the development of lung squamous cell carcinomas (preliminary data section). In this proposal, we will use a standardized green tea preparation called Polyphenon E (PE) and its major component, EGCG. The overall objective of this proposal is to determine the efficacy of green tea polyphenols in a mouse lung squamous cell carcinoma model and to determine the molecular mechanism that underlies the ...
Pathology Department, Harvard Medical School, Boston, Massachusetts 02115-5701, USA. We have investigated the functional integrity of the retinoblastoma tumor suppressor pathway in five human squamous cell carcinoma lines. Elevated activity of cyclin-dependent kinase 6 (cdk6), a pRB kinase, was detected in all five squamous cell carcinoma lines. Overexpression of the cdk6 protein was detected in one of the five cell lines. The cdk6-specific inhibitor p18ink4C is expressed and associated with cdk6 in all five squamous cell carcinoma lines. In contrast, only very low levels of p16ink4A were detected in these cell lines. This may contribute to the elevated activity of cdk6 in these lines. Elevated activity of cdk6 may result in hyperphosphorylation of the retinoblastoma protein and, therefore, compromise its negative growth-regulatory activity ...
TY - JOUR. T1 - Primary squamous cell carcinoma of the breast in a young woman - A case report and review of literature. AU - Vidyasagar, M. S.. AU - Fernandes, D. J.. AU - Ramanujam, A. S.. AU - Suresh Rao, D.. AU - Narayan, Ram. PY - 1998/10/1. Y1 - 1998/10/1. N2 - A thirty-four years old woman presented with pure squamous cell carcinoma of the breast, a very rare occurrence in the younger age group. A simple mastectomy with axillary clearance was performed, followed by adjuvant radiotherapy & chemotherapy. The patient is doing well, with no evidence of recurrence thirty months (21/2 years after the treatment. Primary pure squamous cell carcinoma of the breast is a very rare disease. The exact histogenesis still remains obscure. There seems to be no specific prognostic correlation with the morphological characteristics of squamous cell carcinoma of the breast. The clinical behaviour of this tumor is also uncertain. Thus, further study is required to determine whether primary pure squamous cell ...
Treatment of In November 2006, first lady Laura Bush had a small squamous cell carcinoma removed from her shin. Though hers was a high-profile case, it was by no means unique. An estimated 250,000 new cases of squamous cell carcinoma are diagnosed in the United States every year. And though squamous cell carcinoma was once found mainly in older adults, its occurring with increasing frequency in people younger than 40, Mrs. Bushs cancer was caught and treated early. In such cases, squamous cell carcinoma is highly curable and rarely causes further problems. But untreated squamous cell carcinoma can destroy healthy tissue around the tumor, spread to the lymph nodes or other organs, and occasionally prove fatal, Most squamous cell carcinomas result from prolonged exposure to ultraviolet radiation, either from sunlight or from tanning beds or lamps. Avoiding UV light as much as possible is the best protection. Sunscreen is an important part of a sun-safety program, but by itself doesnt completely prevent
Cutaneous squamous cell carcinoma from the head and neck typically metastasize to the lymph nodes of the neck and parotid glands. When a primary is not identified, they are difficult to distinguish from metastases of mucosal origin and primary salivary gland squamous cell carcinoma. UV radiation causes a mutation pattern that predominantly features cytosine to thymine transitions at dipyrimidine sites and has been associated with cutaneous squamous cell carcinoma. In this study, we used whole genome sequencing data from 15 cutaneous squamous cell carcinoma metastases and show that a UV mutation signature is pervasive across the cohort and distinct from mucosal squamous cell carcinoma. The mutational burden was exceptionally high and concentrated in some regions of the genome, especially insulator elements (mean 162 mutations/megabase). We therefore evaluated the likely impact of UV-induced mutations on the dipyrimidine-rich binding site of the main human insulator protein, CCCTC-binding factor, and the
TY - JOUR. T1 - FGFR gene alterations in lung squamous cell carcinoma are potential targets for the multikinase inhibitor nintedanib. AU - Hibi, Masaaki. AU - Kaneda, Hiroyasu. AU - Tanizaki, Junko. AU - Sakai, Kazuko. AU - Togashi, Yosuke. AU - Terashima, Masato. AU - De Velasco, Marco Antonio. AU - Fujita, Yoshihiko. AU - Banno, Eri. AU - Nakamura, Yu. AU - Takeda, Masayuki. AU - Ito, Akihiko. AU - Mitsudomi, Tetsuya. AU - Nakagawa, Kazuhiko. AU - Okamoto, Isamu. AU - Nishio, Kazuto. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Fibroblast growth factor receptor (FGFR) gene alterations are relatively frequent in lung squamous cell carcinoma (LSCC) and are a potential targets for therapy with FGFR inhibitors. However, little is known regarding the clinicopathologic features associated with FGFR alterations. The angiokinase inhibitor nintedanib has shown promising activity in clinical trials for non-small cell lung cancer. We have now applied next-generation sequencing (NGS) to characterize FGFR ...
Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells. These cells form the surface of the skin lining of hollow organs in the body and line the respiratory and digestive tracts. Common types include: Squamous cell skin cancer: A type of skin cancer Squamous-cell carcinoma of the lung: A type of lung cancer Squamous cell thyroid carcinoma: A type of thyroid cancer Esophageal squamous cell carcinoma: A type of esophageal cancer Despite sharing the name squamous cell carcinoma, the SCCs of different body sites can show differences in their presented symptoms, natural history, prognosis, and response to treatment. Human papillomavirus infection (HPV) has been associated with SCC of the oropharynx, lung, fingers and anogenital region. Ninety percent of cases of head and neck cancer (cancer of the mouth, nasal cavity, nasopharynx, throat and associated structures) are due to squamous cell carcinoma. Primary squamous cell ...
TY - JOUR. T1 - Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. AU - Toutfaire, Marie. AU - Dumortier, Elise. AU - Fattaccioli, Antoine. AU - Van Steenbrugge, Martine. AU - Proby, Charlotte M.. AU - Debacq-Chainiaux, Florence. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun exposure and aging, which is concomitant with an accumulation of senescent cells in the skin. The involvement of senescent cells in carcinogenesis has been highlighted in several cancer types and an interaction between cSCC cells and senescent cells is proposed, but still little explored. Tumor-associated effects are mostly attributed to the senescence-associated secretory phenotype (SASP). Here, we compared two in vitro models of senescence, namely replicative senescence and ...
Recurrent squamous cell carcinoma of the skin treated successfully with single agent cetuximab therapy Selcuk Seber,1 Aylin Gonultas,2 Ozlem Ozturk,2 Tarkan Yetisyigit1 1Department of Medical Oncology, Faculty of Medicine, Namik Kemal University, 2Pathology Department, Tekirdag State Hospital, Tekirdag, Turkey Abstract: Recurrent squamous cell carcinoma of the skin is a rare but difficult to treat condition. Frequently, the disease presents itself in elderly patients with poor performance status and bearing many comorbidities, thus the decision to administer systemic chemotherapy becomes difficult to make. In addition, current chemotherapeutic protocols response rates are far from satisfactory. Recently cetuximab, a chimeric antibody against epidermal growth factor receptor, is increasingly being reported as an alternative treatment. We therefore report this case of a recurrent squamous cell carcinoma of the skin in an elderly woman with poor performance status and who had an excellent clinical
Purpose To discuss the expression of S100A4 and E-cad in oral squamous cell carcinoma (OSCC) and their significance.Methods Expression of S100A4 and E-cad was detected by using immunohistochemical SP method in oral squamous cell carcinoma.Correlation between the expression and clinicopathological features was analyzed.Results Expression of S100A4 had positive correlation with lymph node metastasis (P0.05), and no correlation with histological grade(P0.05). Expression of E-cad had positive correlation with histological grade and negative correlation with lymph node metastasis(P0.05). Inverse relationship between S100A4 and E-cad expression was observed in oral squamous cell carcinoma(P0.05).Conclusions E-cad plays an important role in differentiation of OSCC. E-cad and S100A4 is closely related to invasion and metastasis of OSCC. Expression of S100A4 and E-cadherin is significantly associated with tumor progression in oral squamous cell carcinoma,which are valuable markers in predicting biological
Background: Squamous cell carcinoma accounts for 1% of primary thyroid malignancies and is characterized by a rapidly unfavorable outcome. Case presentation: A 64-year-old woman presented with a painless mass in the left neck, coexisting with thyroid goiter. Total thyroidectomy with lymphadenectomy was performed and a primary thyroid squamous cell cancer was confirmed histologically after excluding any other possible primary malignancies. The tumors immunohistochemical profile was explored using a large panel of antibodies. The tumor featured a positive immunoreaction to cytokeratins 7-19 and to squamous cell carcinoma antigen. Low-molecular-weight cytokeratins 5- 6 and epithelial membrane antigen were also expressed. The neoplasms proliferative index (Mib1) was 60%. No immunostaining was detected for cytokeratins 10-20, thyroglobulin, TTF-1, CD5, galectin-3 or p53. Conclusions: This case of primary thyroid squamous cell carcinoma immunohistochemically profiled using a large panel of ...
Squamous cell carcinoma is the commonest Carcinoma in mucosa. Squamous cell carcinoma is a malignant epithelial neoplasm characterized by variable clinical manifestations metastasis. It most common site in the oral cavity is the lip followed by lateral border of the tongue. Squamous cell carcinoma is radiosensitive and chemo sensitive, but surgery remains the main Modality of treatment. Here we report a successfully treated case of squamous cell carcinoma of left maxilla. Patient was a52 year male who had a swelling in the left palatal region for 6 months. Clinical examination revealed anulceroproliferative lesion involving left palate, alveolus region. Left level 1b (submandibular) lymph node was palpable and hard in consistency with no tenderness. The diagnosis of squamous cell carcinoma was made after incisional biopsy. Treatment of wide excision of tumor, associated cervical lymph node dissection by radiotherapy. The prognosis of squamous cell carcinoma maxilla is high when carcinomatous ...
Squamous cell carcinoma is the second most common skin cancer and is increasing at an alarming rate, particularly in the elderly. Squamous cell carcinoma without question is related directly to sun exposure and also to age. The more sun and sunburns you have had and the longer you live the higher your risk of developing squamous cell carcinoma. They often come from precancerous lesions called actinic or solar keratoses which fair-haired, fair-eyed patients suffer from who have had sunburns as a child and have had chronic sun exposure. These red, raw, itchy, sometimes tender scaly spots on the scalp, face, ears, back of the hands and arms can convert to squamous cell carcinoma. Squamous cell carcinoma can also develop on its own and grow rapidly often fooling patients thinking they are bug bites, boils or infected hairs. These types of squamous cell carcinomas can be dangerous; they present as a nodule that hurts, grow rapidly and have between a 5%-25% risk of spreading or becoming metastatic ...
Gentaur molecular products has all kinds of products like :search , US Biomax \ Lung squamous cell carcinoma tissue array, with TNM, stage and grade, 80 cases_80 cores, replacing BS04011; ihc Anti-Actin confirmed \ LC808 for more molecular products just contact us
AIM: To investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.. METHODS: Twenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.. RESULTS: There were approximately 64% (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7% (8/23) and 26.1% (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1% (13/48) tumor samples had virus oncoprotein E6 ...
TY - JOUR. T1 - Comparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer. AU - Kuwano, Hiroyuki. AU - Morita, Masaru. AU - Tsutsui, Shin‐Ichi ‐I. AU - Kido, Yuichiro. AU - Mori, Masaki. AU - Sugimachi, Keizo. PY - 1991/1/1. Y1 - 1991/1/1. N2 - In ongoing reviews of 339 patients with surgically treated primary squamous cell carcinoma, there were 19 (5.6%) with concurrent gastric cancer and 11 (3.2%) with head and neck cancer. The incidences of intra‐esophageal multiple occurrence of esophageal cancer are 27.3% and 26.3% in those with associated head and neck cancer and gastric cancer, respectively, and higher than 7.1% in those without such a concurrent cancer. There was no difference in the clinicopathological characteristics of those with concurrent head and neck and gastric cancers, except for the higher incidence of metachronous occurrence in the former. These findings suggest that, in cases of esophageal ...
Pathogenetically squamous cell skin cancer presented infiltrative growth thorny layer of skin cells.Due to the malignant (uncontrolled) cell proliferation characteristic of atypia and disarray in the tissue.There are two types of squamous cell carcinoma of the skin: the stratum and neorogovevayuschy.The first is characterized by the persistence of abnormal cells have the ability to keratinization that appears horny pearls in the skin.The second type of cancer more malignant atypical cells completely lose the ability to keratinization.. characteristic localization of squamous cell carcinoma - a red border of lips (usually the lower), the vulva, the perianal region.. Squamous cell carcinoma, unlike papilloma characterized by rapid growth, but is also accompanied by inflammation of the surrounding tissue.. Squamous cell carcinoma can be represented by several morphological forms: ulcer, nodular and blyashkoobraznoy.. for ulcerative forms are characteristic saped region, the presence of bloody ...
The squamous cells make up the outer layer of the skin, nose, and mouth. The squamous cell carcinoma arises when the body?s squamous cells become tumorous. Some general presentations include: sun-induced skin cancer, nasal squamous cell carcinoma, oral squamous cell carcinoma, nasal squamous cell carcinoma.
Lung --Squamous cell carcinoma - download at 4shared. Lung --Squamous cell carcinoma is hosted at free file sharing service 4shared. Online video hosting. Fast file transfer. Enterprise sharing. M Adownload from 4shared
How is Head and Neck Squamous Cell Carcinoma abbreviated? H-NSCC stands for Head and Neck Squamous Cell Carcinoma. H-NSCC is defined as Head and Neck Squamous Cell Carcinoma rarely.
TY - JOUR. T1 - AIS is an oncogene amplified in squamous cell carcinoma. AU - Hibi, Kenji. AU - Trink, Barry. AU - Patturajan, Meera. AU - Westra, William H.. AU - Caballero, Otávia L.. AU - Hill, David E.. AU - Ratovitski, Edward A.. AU - Jen, Jin. AU - Sidransky, David. PY - 2000/5/9. Y1 - 2000/5/9. N2 - We and others recently isolated a human p53 homologue (p40/p51/p63/p73L) and localized the gene to the distal long arm of chromosome 3. Here we sought to examine the role of p40/p73L, two variants lacking the N-terminal transactivation domain, in cancer. Fluorescent in situ hybridization (FISH) analysis revealed frequent amplification of this gene locus in primary squamous cell carcinoma of the lung and head and neck cancer cell lines. (We named this locus AIS for amplified in squamous cell carcinoma.) Furthermore, amplification of the AIS locus was accompanied by RNA and protein overexpression of a variant p68(AIS) lacking the terminal transactivation domain. Protein overexpression in ...
Abstract: Cutaneous squamous cell carcinoma (SCC) occurs commonly and can metastasize. Identification of specific molecular aberrations and mechanisms underlying the development and progression of cutaneous SCC may lead to better prognostic and therapeutic approaches and more effective chemoprevention strategies. To identify genetic changes associated with early stages of cutaneous SCC development, we analyzed a series of 40 archived skin tissues ranging from normal skin to invasive SCC. Using high-resolution array-based comparative genomic hybridization, we identified deletions of a region on chromosome 10q harboring the INPP5A gene in 24% of examined SCC tumors. Subsequent validation by immunohistochemistry on an independent sample set of 71 SCC tissues showed reduced INPP5A protein levels in 72% of primary SCC tumors. Decrease in INPP5A protein levels seems to be an early event in SCC development, as it also is observed in 9 of 26 (35%) examined actinic keratoses, the earliest stage in SCC ...
Squamous cell carcinomas account for about 80% of cancers of the uterine cervix, and the majority of the remainder are adenocarcinomas. There is limited evidence on the extent to which these histological types share a common etiology. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374 women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies. Compared to controls, the relative risk of each histological type of invasive cervical cancer was increased with increasing number of sexual partners, younger age at first intercourse, increasing parity, younger age at first full-term pregnancy and increasing duration of oral contraceptive use. Current smoking was associated with a significantly increased risk of squamous cell carcinoma (RR = 1.50, 95% CI: 1.35-1.66) but not of adenocarcinoma (RR = 0.86 (0.70-1.05)), and
Squamous cell carcinomas account for about 80% of cancers of the uterine cervix, and the majority of the remainder are adenocarcinomas. There is limited evidence on the extent to which these histological types share a common etiology. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 8,097 women with invasive squamous cell carcinoma, 1,374 women with invasive adenocarcinoma and 26,445 women without cervical cancer (controls) from 12 epidemiological studies. Compared to controls, the relative risk of each histological type of invasive cervical cancer was increased with increasing number of sexual partners, younger age at first intercourse, increasing parity, younger age at first full-term pregnancy and increasing duration of oral contraceptive use. Current smoking was associated with a significantly increased risk of squamous cell carcinoma (RR = 1.50, 95% CI: 1.35-1.66) but not of adenocarcinoma (RR = 0.86 (0.70-1.05)), and
Semantic Scholar extracted view of Head and neck squamous cell carcinoma cell lines as a model system for the study of oncogene expression during tumor progression and metastasis. by Gary Edward Gallick et al.
An investigation was conducted to assess the incidence and. identify the predisposing factors of bovine squamous cell carcinoma in Kenya. The incidence, breed susceptibility, sites of origin and age distribution of squamous cell carcinoma found in the four breeds of grade cattle in Kenya are reported along with the observed correlation between lack of pigmentation of the bovine vulvae and occurrence of bovine vulva carcinoma. Typical examples of the histology of bovine squamous cell carcinoma which were observed during histological diagnosis are also shown. The data of 18 cattle with vulva carcinoma and 48 cattle with ocular carcinoma on which immunotherapy trials were conducted are reported. The details of the preparation of the saline phenol extract of bovine squamous cell carcinoma used in the study are outlined. The methods by which immunotherapy trials were conducted are described. rIt was found that bovine vulva carcinoma and bovine ocular carcinoma on the eyelid skins did not respond to ...
Squamous cell carcinoma is the most common type of oral cancer, and makes up about 90% of all oral cancer diagnoses. Squamous cells are the flat cells that line the tissues inside your mouth; when these cells become abnormal, squamous cell carcinoma is the result. Heres what you need to know about this condition.. Why does this cancer develop?. Squamous cell carcinoma develops when your cells become abnormal, but why does this happen? There are many reasons. Smoking cigarettes, drinking alcohol, and having HPV infection are considered the main causes, but other things also increase the risk of your cells becoming abnormal. Excessive sun exposure and exposure to x-rays can also cause this type of cancer. You can also develop this cancer without having any of these risk factors since doctors still havent discovered every single cause of cancer. Where can it develop?. Squamous cell carcinoma can affect any of the tissues inside of your mouth. It can form on the inside of your cheeks, on your ...
Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014SummaryGlobal Markets Directs, Head And Neck Cancer Squamous Cell Carcinoma - Pipeline Review, H2 2014, provides an overview of the Head And Neck Cancer Squamous Cell Carcinomas therapeutic pipeline.This report provides comprehensive information on the therapeutic development for Head And Neck Cancer Squamous Cell Carcinoma, co
Mutations in the tumor suppressor gene TP53 and proto-oncogene PIK3CA and alterations of p53 and PIK3CA AKT mTOR pathways are common events in several human cancers. We focused on the analysis of TP53 and PIK3CA gene variations in adenocarcinoma, squamous cell carcinoma as well as in intraepithelial neoplasia grade 3 of the cervix. DNA samples from 28 cervical adenocarcinoma, 55 squamous cell carcinoma and 31 intraepithelial neoplasia grade 3 (CIN3), previously characterized in terms of human papillomavirus (HPV) prevalence and genotype distribution, were analyzed for TP53 and PIK3CA mutations in the exons 4-9 and exon 9, respectively. Single nucleotide substitutions in TP53 and PIK3CA genes were detected in 36% and 11% of adenocarcinoma, in 16% and in 5% of squamous cell carcinoma, and in 13% and none of CIN 3, respectively. Nucleotide changes in TP53 were significantly more frequent in adenocarcinoma cases than in squamous cell carcinoma and CIN3 (P = 0.035) and were independent from HPV infection
Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare. Eleven years prior, a seventy-year-old woman had been treated with transthoracic radical oesophagectomy for oesophageal squamous cell carcinoma. Four years prior, she had undergone chemotherapy for lymph node recurrence at the splenic hilum and achieved a partial response. She had also received chemoradiotherapy for lymph node recurrence at the splenic hilum 3 years prior; a complete response was achieved. However, routine follow-up with abdominal computed tomography recently revealed a tumour at the pancreatic tail and swollen lymph nodes. The patient underwent distal pancreatectomy on the basis of a pre-operative diagnosis of primary pancreatic cancer, although a histological examination of the surgical specimen revealed metastatic squamous cell carcinoma that was compatible with metachronous
Gentaur molecular products has all kinds of products like :search , US Biomax \ Cervix squamous cell carcinoma tissue array with matched adjacent cervix tissue, including TNM and pathology grade, 16 cases_48 cores \ CR484 for more molecular products just contact us
Esophagus squamous cell carcinoma tissue array, including TNM and pathology grade, 48 cases 96 cores related publications, related pathways and related gentaur products
Tonsillar squamous cell carcinoma, which represents 10% of head and neck malignancies, rarely manifests with cutaneous metastases; to date, only three prior patients with tonsillar squamous cell carcinoma have been reported to develop cutaneous metastases. We describe the clinical features of a 59-year-old man with squamous cell carcinoma of the tonsil who developed cutaneous metastases within his prior radiation port and review the literature of prior patients with cutaneous metastases from tonsillar squamous cell carcinoma. The PubMed database was searched for the following keywords: carcinoma, cutaneous, metastasis, squamous, and tonsil. The papers generated by the search and their references were reviewed. Cutaneous metastasis from tonsillar cancer is rare but should be considered in patients with a history of a squamous cell carcinoma of the tonsil; new skin lesions, both overlying the visceral malignancy and at more distant sites, should be biopsied since prognosis in these patients is poor.
Cisplatin is widely used for chemotherapy of head and neck squamous cell carcinoma. However, details of the molecular mechanism responsible for cisplatin resistance are still unclear. The aim of this study was to identify the expression of genes related to cisplatin resistance in oral squamous cell carcinoma cells. A cisplatin-resistant cell line, Tca/cisplatin, was established from a cisplatin-sensitive cell line, Tca8113, which was derived from moderately-differentiated tongue squamous cell carcinoma. Global gene expression in this resistant cell line and its sensitive parent cell line was analyzed using Affymetrix HG-U95Av2 microarrays. Candidate genes involved in DNA repair, the MAP pathway and cell cycle regulation were chosen to validate the microarray analysis results. Cell cycle distribution and apoptosis following cisplatin exposure were also investigated. Cisplatin resistance in Tca/cisplatin cells was stable for two years in cisplatin-free culture medium. The IC50 for cisplatin in Tca
TY - JOUR. T1 - Malignant Brenner tumor mimicking a primary squamous cell carcinoma of the cervix. AU - Badve, Sunil. AU - Fehmian, C.. AU - Cass, I.. AU - Goldberg, G. L.. AU - Jones, J. G.. PY - 1999/9. Y1 - 1999/9. N2 - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant squamous differentiation eroding the cervix and simulating a primary cervical malignancy. We describe this case and review the literature on metastatic tumors to the cervix.. AB - An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. Histology showed a malignant Brenner tumor with abundant ...
TY - JOUR. T1 - Role of Penile Doppler US in the Preoperative Assessment of Penile Squamous Cell Carcinoma Patients. T2 - Results From a Large Prospective Multicenter European Study. AU - Bozzini, Giorgio. AU - Provenzano, Marco. AU - Romero Otero, Javier. AU - Margreiter, Markus. AU - Garcia Cruz, Eduardo. AU - Osmolorskij, Boris. AU - Verze, Paolo. AU - Pavan, Nicola. AU - Sanguedolce, Francesco. AU - Buffi, Nicolò. AU - Ferrucio, Guazzoni Giorgio. AU - Taverna, Gian Luigi. PY - 2016/4/1. Y1 - 2016/4/1. N2 - Objective To determine the role of penile Doppler ultrasound (PDU) compared with magnetic resonance imaging (MRI) in preoperative diagnostic evaluation of patients with penile squamous cell carcinoma. Materials and Methods A prospective analysis on patients presenting with clinical diagnosis of penile squamous cell carcinoma from 6 different European hospitals between 2012 and 2014 was carried out. Each patient who had planned an organ sparing approach underwent an MRI and PDU both with ...
Fingerprint Dive into the research topics of Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: A clinical-pathologic correlation. Together they form a unique fingerprint. ...
Background The National Comprehensive Cancer Network guidelines recommend that patients with oral cavity squamous cell carcinoma (OSCC) and cT4b disease should be either included in clinical trials or...
Parikh A., Shin J. H., Faquin W., Lin D. T., Tirosh I., Sunwoo J. B. & Puram S. V. (2020). Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma. Journal for ImmunoTherapy of Cancer. 2020, 8 (2). ...
Philippine General Hospital, University of the Philippines Manila. Objective. This study aims to determine the prevalence and pattern of thyroid gland involvement in advanced laryngeal squamous cell carcinoma and to identify factors associated with its development.. Method. Records of 118 patients who underwent laryngectomy with thyroidectomy for advanced laryngeal squamous cell carcinoma in a tertiary government hospital from January 2010 to August 2015 were reviewed. Demographic, clinical and histopathology data were obtained. The relationship of the laterality of primary tumor bulk and lobe involvement was analyzed using Fischers exact test. The association between thyroid gland invasion and other factors was analyzed using logistic regression.. Results. Thyroid gland involvement was found in 11% of the patients via direct spread in 92.3%. Single lobe involvement accounted for 61.5% of cases. There is a tendency for laryngeal squamous cell carcinoma to invade the thyroid lobe ipsilateral to ...
Klotho is known as an anti‑aging gene. We previously reported that the expression of Klotho is a postoperative prognostic factor for patients with lung large cell neuroendocrine carcinoma and lung small cell carcinoma. Recently, Klotho was shown to suppress the epithelial‑mesenchymal transition (EMT). In the present study, we examined the association between the expression of Klotho and the regulation of EMT in lung squamous cell carcinoma. We immunohistochemically examined the expression of Klotho in patients with lung squamous cell carcinoma who had undergone surgical resection or photodynamic therapy. The immunohistochemical analysis showed that Klotho expression was observed not only in normal bronchial epithelial cells, but also in centrally located early lung cancers, which were all carcinomas in situ and were treated using PDT. However, in lung cancer patients with invasive and or advanced squamous cell carcinoma who had undergone a complete surgical resection, Klotho expression was ...
Aggressively de-escalated adjuvant radiotherapy for patients with HPV-associated oropharynx squamous cell carcinoma produced local tumor control rates comparable to those of historical controls, according to results of a single-arm phase 2 study published in Journal of Clinical Oncology.. The de-escalated treatment also was associated with decreased toxicity and slight improvement in swallowing function.. HPV-associated oropharyngeal squamous cell carcinoma represents a demographically and biologically distinct disease compared with historical head and neck squamous cell carcinomas, Daniel J. Ma, MD, radiation oncologist at Mayo Clinic in Rochester, Minnesota, and colleagues wrote. Patients are more likely to be younger and nonsmokers and have fewer medical comorbidities. Furthermore, in vitro and in vivo experiments have demonstrated that these tumors are more sensitive to radiotherapy and chemotherapy compared with historical head and neck squamous cell carcinomas.. The current standard ...
Basaloid squamous cell carcinoma (Bas-SqCC) is an uncommon histological variant of lung cancer composed of cells exhibiting cytological and tissue architectural features of both squamous cell lung carcinoma and basal cell carcinoma. Lung cancer is a large and exceptionally heterogeneous family of malignancies. Over 50 different histological variants of lung cancer are explicitly recognized within the fourth (2004) revision of the World Health Organization Classification of Lung Tumours (WHO-2004). Many of these entities are quite rare, have only been recently described, and remain poorly understood. Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. In the third revision of the World Health Organization lung tumor typing and classification scheme, published in 1999, basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct ...
TY - JOUR. T1 - Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma. AU - Chamseddin, Bahir H.. AU - Lee, Eunice E.. AU - Kim, Jiwoong. AU - Zhan, Xiaowei. AU - Yang, Rong. AU - Murphy, Kathleen M.. AU - Lewis, Cheryl. AU - Hosler, Gregory A.. AU - Hammer, Suntrea T.. AU - Wang, Richard C.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Anal squamous cell carcinoma (ASCC) is a rare, potentially fatal malignancy primarily caused by high-risk human papillomaviruses (HPV). The prognostic implication of programmed death-ligand 1 (PD-L1) expression remains controversial, and glucose transporter 1 (GLUT1) expression has never been examined in ASCC. Covalently closed circular RNAs have recently been shown to be widespread in cancers and are proposed to be biomarkers. We discovered HPV16 expresses a circular E7 RNA (circE7) which has not been assessed as a potential biomarker. A retrospective, translational case series at UT Southwestern was conducted to analyze PD-L1, GLUT1, ...
Conditions: Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent ...
Title: 5-Fluorouracil Buccal Tablets for Locoregional Chemotherapy of Oral Squamous Cell Carcinoma: Formulation, Drug Release and Histological Effects on Reconstituted Human Oral Epithelium and Porcine Buccal Mucosa. VOLUME: 7 ISSUE: 2. Author(s):Libero Italo Giannola, Viviana De Caro, Giulia Giandalia, Maria Gabriella Siragusa, Carlo Paderni, Giuseppina Campisi and Ada Maria Florena. Affiliation:Department of Chemistry and Pharmaceutical Technologies, University of Palermo, Via Archirafi 32,90123 Palermo, Italy.. Keywords:5-Fluorouracil, Locoregional drug delivery, Porcine buccal mucosa, Reconstituted human oral epithelium, Oral squamous cell carcinoma, Buccal tablets. Abstract: 5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug delivery have been reported. In this study we would report the development ...
TY - JOUR. T1 - Cutaneous squamous cell carcinoma metastasis to the parotid region lymph nodes. AU - Myers, Larry L. AU - Ahn, Chul. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Objective: To determine the effect on survival of periauricular region cutaneous squamous cell carcinomas (cSCC) metastasizing to parotid region and cervical lymph nodes. Methods: From May 1995 to October 2013, consecutive patients with cSCC undergoing parotidectomy/neck dissection ≥ 18 years without distant metastasis were included. Demographic, clinical, and pathologic data were analyzed. Uni- and multivariate analyses of disease-specific survival and overall survival were performed. Statistical significance was set at P , 0.05. Results: We evaluated 137 patients. Most patients were Caucasian males with an average age of 71.6 years. The median follow-up time was 29.4 months. Thirty-six percent of patients had pathological evidence of cervical metastasis (N+). Seven percent had metastasis to level I, 21.9% to level II, 14.6% to ...
Laryngeal and hypopharyngeal squamous cell carcinomas (LHSCCs) are common head and neck cancers with a high propensity for lymph node (LN) and lung metastasis. Here, we report that LHSCCs express high levels of functional CXCR4 receptors, native for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). Primary tumor immunohistochemistry from LHSCC patients has revealed significant expression of CXCR4 and CXCL12. Greater expression of CXCR4 but not that of CXCL12 is correlated with LN and distant metastasis. Reverse transcription-polymerase chain reaction and western blots have demonstrated that CXCR4 messenger RNA (mRNA) and protein were expressed in LHSCC cell lines as well, but failed to detect CXCL12 mRNA expression. CXCL12 treatment enhanced extracellular signal-regulated kinase (ERK) pathway activation and the motility/invasiveness of LHSCC cell lines, which were blocked by treatment with a CXCR4 antagonist (AMD3100) and a specific MEK inhibitor (U0126). Results show that the mRNA and ...
Tongue squamous cell carcinoma (TSCC) is one of the most common types of oral squamous cell carcinomas (OSCC). TSCC is highly invasive and
Our aim was to document the health-related quality of life (QoL) of patients with squamous cell carcinoma (SCC) of the oral cavity who were treated with chemoradiotherapy, and to compare it with that of patients treated with conventional surgery with or without adjuvant treatment. All patients who presented with SCC of the oral cavity treated with chemoradiotherapy alone at the Royal Brisbane & Womens Hospital between 2000 and 2011 and who were alive without disease were included. Health-related QoL was assessed by the University of Washington QoL questionnaire version 4, and the European Organisation for the Research and Treatment of Cancer (EORTC) QoL questionnaires C30 and HN35. The questionnaires were sent to all survivors. Those who responded to chemoradiotherapy were matched with patients who were treated by conventional surgery with or without adjuvant treatment by age, sex, subsite of tumour, and TNM stage. Sixteen patients completed the questionnaires (8 in each group). There was no ...
The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response. Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. The presence of HPV was detected by chromogenic in situ hybridization. Hsp and GHRH-R expressions were determined using immunohistochemistry. Following neoadjuvant or definitive radiochemotherapy, the patients were restaged according to the Response Evaluation Criteria in Solid Tumors. The correlation between the HPV status, response to treatment and Hsp and GHRH-R expressions were evaluated. Fourteen (19%) patients were HPV-positive. These patients were more likely to respond
The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response. Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. The presence of HPV was detected by chromogenic in situ hybridization. Hsp and GHRH-R expressions were determined using immunohistochemistry. Following neoadjuvant or definitive radiochemotherapy, the patients were restaged according to the Response Evaluation Criteria in Solid Tumors. The correlation between the HPV status, response to treatment and Hsp and GHRH-R expressions were evaluated. Fourteen (19%) patients were HPV-positive. These patients were more likely to respond
Telomerase is a ribonucleoprotein enzyme that maintains telomere length. Telomerase activity is primarily attributed to the expression of telomerase reverse transcriptase (TERT). It has been reported that introduction of an intact human chromosome 3 into the human oral squamous cell carcinoma cell line HSC3 suppresses the tumorigenicity of these cells. However, the mechanisms that regulate tumorigenicity have not been elucidated. To determine whether this reduction in tumorigenicity was...
Health care professionals may find information about advanced esophageal squamous cell carcinoma (ESCC) and KEYTRUDA® (pembrolizumab).
Squamous cell carcinoma of the gallbladder is rare and constitutes only 0.5-3% of all malignancies of this organ. Most of the reported cases have had a component of adenocarcinoma. We report a 70-year-old man who presented with acute onset right upper quadrant pain. He operated on based on a presumptive diagnosis of acute cholecystitis according to clinical and ultrasonographic findings. Histopathological examination of the infiltrating mass of the gallbladder revealed well differentiated keratinized squamous cell carcinoma invading full wall thickness. Thorough evaluations revealed no other primary site for the tumor. Pure primary squamous cell carcinoma of the gallbladder is rarely reported. Clinicians and pathologists must be aware of its vague clinical presentations.
Background: Recently, associations of the human papillomavirus (HPV) with head and neck cancer have become well established. Of particular concern, the severity and pathological outcomes of squamous cell carcinomas are remarkably affected by the genotypes of HPV present in such lesions. This study was conducted to investigate the occurrence of HPV genotypes, particularly high risk 16 and 18, among oral and laryngeal squamous cell carcinomas in Jordan. Methods: During the period of May 2015 to March 2016, we evaluated a total of 108 paraffin-embedded tissue samples, histologically confirmed as SCC, of both oral and laryngeal tumors for the presence of HPV DNA. DNA was extracted using a Zymogen commercial kit. HPV genotypes were detected by nested PCR using consensus primers followed by primer-specific PCR for HPV-16 and HPV-18 genotypes. The genotypes were confirmed by DNA sequencing methods. Results: Sixteen samples were positive for HPV DNA (14.8%) with higher rates in oral tumors compared to their
Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in developing countries, especially in Eastern Asia [ 1 ].
The presence of Lymph node metastasis with extranodal extension (ENE) is considered to be an important adverse prognostic factor for survival in patients with head and neck cancer. The aim of this study was to determine the prognostic significance of ENE in patients with laryngeal squamous cell carcinoma (LSCC). Three hundred and fifty-five patients with LSCC who underwent surgical resection and neck dissection were included. The status of cervical lymph node was classified into three groups: pathological negative nodal (pN-), pathological positive nodal without ENE (ENE-), and pathological positive nodal with ENE (ENE+). A total of 85 of 355 (23.9%) LSCC were pathological nodal positive, and ENE was detected in 22/355 (6.2%) patients. ENE was associated with drinking (p=0.005), T stage (p=0.000), tumor location (p=0.000), and differentiation degree (p=0.000). The number of lymph node metastasis in ENE+ group was associated with almost twice compared to ENE- group (p=0.005). The 5-year overall ...
TY - CONF. T1 - Molecular pathogenesis of human esophageal squamous cell carcinomas. AU - Tang, Cheuk On. AU - Hu, Y.C.. AU - Law, B.F.. AU - Wong, K.Y.. AU - Hu, L.. AU - Guan, X.Y.. AU - Srivastava, G.. PY - 2002. Y1 - 2002. M3 - Conference presentation (not published in journal/proceeding/book). T2 - Hong Kong International Cancer Congress. Y2 - 1 January 2002. ER - ...
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. MicroRNA (miRNA)‑544 is an important cancer‑associated RNA that is downregulated in multiple types of cancer. However, the role of miR‑544 in ESCC progression remains unknown. In the present study, miR‑544 expression level was determined via RT‑qPCR in 30 pairs of ESCC and adjacent normal tissues and in a panel of ESCC cell lines. Cell proliferation and cell apoptosis were assessed by MTT and flow cytometry assays. Luciferase reporter assay and western blot analysis were conducted to verify E2F transcription factor 5 (E2F5), an oncogene in ESCC, as a novel target gene of miR‑544. The results illustrated that miR‑544 is frequently downregulated in ESCC tissues and cell lines. Overexpression of miR‑544 in ESCC cells resulted in decreased cell proliferation and increased cell apoptosis. Thus, E2F5 was identified as a target of miR‑544, and its expression was negatively correlated with ...
Since this squamous cell lung cancer is being considered as destructive neoplasm in lungs, additional care is paid towards incorporating the effective supportive therapy in the regular anti cancerous therapy, involving multi drug combinations. The supportive therapy may include usage of suitable corticosteroid drugs like prednisolone in a routine form and it is noteworthy to mention that in some patients, a repository form of this corticosteroid may also be used to fulfill the need of constant delivery.. Surgery is also being considered as therapy in cases of squamous cell lung cancer. But, if the spread of this is over a wide area, it becomes impossible.. The squamous cell lung cancer in many patients tends to spread to other tissues including kidney or bone. Suppose, if it spreads to bones, most of the times, mandible or skull may get affected and in such cases increased density with occurrence of periosteal new bones may be noticed.. Squamous cell lung cancer at times need confirmation from ...
Esophageal basaloid squamous cell carcinoma (EBSCC) is a rare malignant disease. Advanced EBSCC (AEBSCC) has a poorer prognosis than the more common esophageal squamous cell carcinoma, but no treatment policy has yet been established. This is the first reported case with AEBSCC treated only with radiotherapy. Thus, our long-surviving patient merits consideration. We therefore reviewed cases with the same stage of AEBSCC for further investigation. An 85-year-old man with a chief complaint of difficulty swallowing foods was diagnosed with AEBSCC, cT3N1M0, stage III, by thorough examination. The basaloid carcinoma extended from the upper thoracic esophagus to the middle thoracic esophagus based on imaging studies, endoscopy and biopsy. Morphologically, the tumor was an elevated ulcerative area. We conducted radiotherapy to relieve symptoms, as the patient and his family refused aggressive treatment. He has remained alive without recurrence for 2 years, to date, after completing radiotherapy. Basaloid
TY - JOUR. T1 - Lactate Transporter Monocarboxylate Transporter 4 Induces Bone Pain in Head and Neck Squamous Cell Carcinoma. AU - Hasegawa, Kazuaki. AU - Okui, Tatsuo. AU - Shimo, Tsuyoshi. AU - Ibaragi, Soichiro. AU - Kawai, Hotaka. AU - Ryumon, Shoji. AU - Kishimoto, Koji. AU - Okusya, Yuka. AU - Monsur Hassan, Nur Mohammad. AU - Sasaki, Akira. PY - 2018/10/25. Y1 - 2018/10/25. N2 - Head and neck squamous cell carcinoma (HNSCC) poses a significant challenge clinically, as it can invade facial bones and cause bone pain that is undertreated and poorly understood. Here we studied HNSCC bone pain (HNSCC-BP) in an intratibial mouse xenograft model that uses a human HNSCC cell line (SAS cells). These mice develop HNSCC-BP associated with an upregulation of phosphorylated ERK1/2 (pERK1/2), which is a molecular indicator of neuron excitation in the dorsal root ganglia (DRGs) of sensory nerve cell bodies. Our experiments demonstrated that the inhibition of monocarboxylate transporter 4 (MCT4) by short ...
TY - JOUR. T1 - Incidental case of metastatic squamous cell carcinoma in the posterior thoracic wall. T2 - A cadaveric finding. AU - Kumar, Naveen. AU - Aithal, Ashwini P.. AU - Bishnu, Arijit. AU - Swamy, R. Ravindra. PY - 2016. Y1 - 2016. N2 - Occurrence of secondary tumors from visceral carcinomas on the thoracic cage represent a relatively rare form of metastasis. We present in this report an extremely rare case of an incidental finding of tumor mass (squamous cell carcinoma) in the thoracic wall of an adult male cadaver. During routine dissection of thoracic cavity, we noticed this unique tumor in the posterior thoracic wall. Its gross measurements were noted and a small piece of the tumor mass was processed for histopathological examination, to confirm its nature. The H&E stained section showed presence of infiltrating tumor composed of islands of squamous cells with pleomorphic nuclei, course chromatin, scattered dyskeratotic cells and foci of keratin pearl formation, which confirmed the ...
Bupivacaine inhibits the malignant biological behavior of oral squamous cell carcinoma cells by inhibiting the activation of ERK1/2 and STAT3
Despite improvement in preoperative imaging, surgical technique, and adjuvant therapy, the prognosis of patients with tongue squamous cell carcinoma (SCC) is still unsatisfactory. The mammalian target of rapamycin (mTOR) play a key role in the regulation of tumor cell proliferation and survival. However, the significance of mTOR on the prognosis of tongue SCC remains largely undefined. In the present study, immunohistochemistry was performed to evaluate the expression of phosphorylated mTOR (p-mTOR) in 160 surgically resected tongue SCC, and correlated with survival. Univariate analysis revealed that p-mTOR overexpression (P = 0.006) was associated with inferior overall survival. In multivariate comparison, p-mTOR overexpression (P = 0.002, hazard ratio = 2.082) remained independently associated with worse overall survival. In vitro study, tongue cancer cells treated with everolimus, the specific mTOR inhibitor, or transfected with mTOR-mediated siRNAs dramatically attenuated the abilities of ...
TY - JOUR. T1 - Novel pactamycin analogs induce p53 dependent cell-cycle arrest at S-phase in human head and neck squamous cell carcinoma (HNSCC) cells. AU - Guha, Gunjan. AU - Lu, Wanli. AU - Li, Shan. AU - Liang, Xiaobo. AU - Kulesz-Martin, Molly. AU - Mahmud, Taifo. AU - Indra, Arup Kumar. AU - Ganguli-Indra, Gitali. PY - 2015/5/4. Y1 - 2015/5/4. N2 - (AKI) Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7-deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma (HNSCC) cell lines SCC25 and SCC104. Both TM-025 and TM-026 exert growth inhibitory effects on HNSCC cells by inhibiting cell proliferation. Interestingly, unlike their parent compound pactamycin, the analogs do not inhibit synthesis of nascent protein in a cell-based ...
Mutation plot summary of 60 oral tongue squamous cell carcinoma patients showing frequently mutated genes. The top plot shows the key clinical parameters, below
Basal and squamous cell carcinomas[edit]. The most common forms of skin cancer in humans, basal and squamous cell carcinomas, ... These cancers are relatively mild and rarely fatal, although the treatment of squamous cell carcinoma sometimes requires ... having cells that form when the DNA is damaged by UV radiation. The findings suggest "rising UV levels as a result of ozone ...
Squamous-cell carcinoma is the second-most prevalent skin cancer, followed by melanoma. Squamous-cell carcinoma and melanoma ... 694 Knottenbelt and McGarry, Squamous cell carcinoma, pg. 427 Knottenbelt and McGarry. Squamous cell carcinoma., pg. 433. ... epidermal skin cells that become keratinized. Squamous-cell carcinomas are often solitary, slow-growing tumors that cause ... Squamous-cell carcinoma (SCC) is the most common cancer of the eye, periorbital area and penis, and it is the second most ...
Squamous cell carcinoma is a cancer of the squamous cells, a type of epithelial cell, and is the second most-common type of ... "Squamous Cell Carcinoma". Skin Cancer Foundation. Retrieved December 31, 2016. Skloot 2010, p. 27. World Cancer Report 2014. ... 10% to 15% of cancers of the cervix are adenocarcinomas, the rest more commonly being squamous cell carcinomas. The roller-tube ... The cells from the cancerous sample eventually became known as the HeLa immortal cell line, a commonly used cell line in ...
... also known as oropharyngeal squamous cell carcinoma (OPSCC) and tonsil cancer, is a disease in which abnormal cells with the ... Oropharyngeal Squamous Cell Carcinoma. StatPearls (Updated ed.). Treasure Island (FL): StatPearls Publishing. doi:10.32388/ ... OPC is staged according to the appearance of the abnormal cells on the biopsy coupled with the dimensions and the extent of the ... The National Cancer Institute (2016) provides the following definition: Abnormal cells are found in the lining of the ...
A, Fatima; Zohaib, J (4 December 2020). "Oropharyngeal Squamous Cell Carcinoma". Definitions. StatPearls (Updated ed.). ... is strongly associated with a higher risk of developing head and neck cancer as well as oropharyngeal squamous cell carcinoma ( ...
Alam, Murad; Ratner, Désirée (2001). "Cutaneous Squamous-Cell Carcinoma". New England Journal of Medicine. 344 (13): 975-83. ... "Merkel cell carcinoma". Journal of the National Comprehensive Cancer Network. 7 (3): 322-32. doi:10.6004/jnccn.2009.0024. PMID ... His work has also extended to serving on expert panels such as those dedicated to merkel cell cancer and guidelines of care. He ...
July 2010). "Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population ... Studies have also shown a link between a wide range of HPV types and squamous cell carcinoma of the skin. In such cases, in ... November 2005). "The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck ( ... 2013). "Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in ...
HPV type 16 is also responsible for almost 90% of HPV-positive oropharyngeal squamous-cell carcinoma (OPSCC), a form of cancer ... Lay summary (PDF). Anjum, Fatima; Zohaib, Jamal (4 December 2020). "Oropharyngeal Squamous Cell Carcinoma". Definitions. ... of head and neck squamous cell carcinoma). In principle, HPV vaccines may help reduce incidence of such cancers caused by HPV, ... Vousden KH (1994). Cell transformation by human papillomaviruses. Viruses and Cancer. New York: Press Syndicate of the ...
Anjum, Fatima; Zohaib, Jamal (4 December 2020). "Oropharyngeal Squamous Cell Carcinoma". Definitions. StatPearls (Updated ed ... Since expression of E6 and E7 is required for promoting the growth of cervical cancer cells (and cells within warts), it is ... While most cervical cancer arises in the squamous cells, adenocarcinomas make up a sizable minority of cancers. Further, Pap ... June 2016). "Sequence-based approach for rapid identification of cross-clade CD8+ T-cell vaccine candidates from all high-risk ...
Anjum, Fatima; Zohaib, Jamal (4 December 2020). "Oropharyngeal Squamous Cell Carcinoma". Definitions. StatPearls (Updated ed ... Skin tag Inverted papilloma Squamous cell papilloma Urothelial papilloma Intraductal papilloma of breast Wart Genital wart ... squamous cell papilloma) caused by human papillomavirus (HPV), such as warts. Human papillomavirus infection is a major cause ... of cases of squamous cell papilloma. There is no evidence that papillomas are premalignant. Intraoral verruca vulgaris, ...
Basal cell carcinoma Fleshy, growing mass Areas exposed to the sun Squamous cell carcinoma Unusual growth that is red, scaly or ...
Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ... The relative increase in percentage of CD8+ T cells, caused by a reduction in numbers of CD4+ T cells may be implicated in RAS- ... Mast cells and macrophages are also involved, secreting TNF-α along with the T cells. When early aphthous ulcers are biopsied, ... and the ratio of CD4+ T cells to CD8+ T cells in the peripheral blood of individuals with aphthous stomatitis is decreased.[5] ...
Squamous cell carcinoma. *Adenocarcinoma. Stomach. *Gastric carcinoma. *Signet ring cell carcinoma. *Gastric lymphoma *MALT ... LHCGR (Luteinizing hormone insensitivity, Leydig cell hypoplasia, Male-limited precocious puberty). *FSHR (Follicle-stimulating ...
Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... The three main subtypes of NSCLC are adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma.[1] ... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ... typically leading to squamous-cell lung carcinoma. In the middle airways, implicated stem cells include club cells and ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... An odontoblast cell showing odontoblast process (not in proportion - in reality this process is far longer than the body of the ...
Squamous cell carcinoma. *Adenocarcinoma. Stomach. *Gastric carcinoma. *Signet ring cell carcinoma. *Gastric lymphoma *MALT ...
... with squamous cell carcinoma being the most common type. The incidence of squamous cell carcinoma increases to 37% when the ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... Tenderness at the base of the lesion is often a clue to the presence of a possible underlying squamous cell carcinoma.[citation ... or squamous cell carcinoma (a form of skin cancer). These can look essentially identical clinically. The only reliable way to ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... shedding of surface epithelial cells).[5] Many people with BHT are heavy smokers.[5] Other possible associated factors are poor ...
The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ... Cytotoxic drugs administered during chemotherapy target cells with fast turnovers such as malignant cells. However, the ... Only the superficial epithelial cells of the epidermis or of the mucosa are lost, and the lesion can reach the depth of the ... Malignancies in the mouth are usually carcinomas, but lymphomas, sarcomas and others may also be possible. Either the tumor ...
Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas, ... The next most common type, acinar cell carcinoma of the pancreas, arises in the clusters of cells that produce these enzymes, ... undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast-like giant cells. Solid pseudopapillary tumor is a ... Squamous cell carcinoma. *Adenocarcinoma. Stomach. *Gastric carcinoma. *Signet ring cell carcinoma. *Gastric lymphoma *MALT ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... The involvement of a subset of T cells (Th17) seems to be important.[9] The primary cause is not well known. In fact, no one ... eye inflammation (iritis, uveitis, retinal vasculitis, cells in the vitreous). *genital ulcers (including anal ulcers and spots ... "Humoral and cell mediated immune response to cow's milk proteins in Behçet's disease". Ann. Rheum. Dis. 61 (5): 459-62. doi ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... Histologically, the epithelial cells show signs of intracellular and extracellular edema.[citation needed] ...
Squamous cell carcinoma. *Adenocarcinoma. Stomach. *Gastric carcinoma. *Signet ring cell carcinoma. *Gastric lymphoma *MALT ...
Squamous cell carcinoma no Keratinizing, Nonkeratininzing, Basalaoid, Verrucous, Warty [16][17][18] ... Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain. ... these include leukemia and most forms of carcinoma in situ. Tumor is also not synonymous with cancer. While cancer is by ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... Inflammation (day 1): Virus begins reproducing and infecting cells at the end of the nerve. The healthy cells react to the ... Post-scab (12-14 days): A reddish area may linger at the site of viral infection as the destroyed cells are regenerated. Virus ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... or plasma cell gingivitis, which may be accompanied by glossitis and cheilitis.[10] Apart from BMS itself, a full list of ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Kobielak A, Fuchs E (February 2006). "Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin". Proc. Natl ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... Catenin and EMT interactions may also play a role in hepatocellular carcinoma. VEGF-B treatment of hepatoma carcinoma cells can ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ... the increased production of oily sebum causes the dead skin cells to stick together.[10] The accumulation of dead skin cell ...
Squamous cell carcinoma may occasionally develop, usually in chronic cases, and at the edge of ulcer.[citation needed] Tetanus ... Chronic ulcers involve larger area and may eventually develop into squamous epithelioma after 10 years or more. Skin color: ...
"Role of afatinib in the treatment of advanced lung squamous cell carcinoma". Clinical Pharmacology. 9: 147-157. doi:10.2147/ ... Afatinib, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC). ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... May 2012). "Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of ...
... or tumors such as lymphoma or squamous cell carcinoma. A tonsillolith (also known as a "tonsil stone") is material that ... These M cells then alert the underlying B cells and T cells in the tonsil that a pathogen is present and an immune response is ... The tonsils have on their surface specialized antigen capture cells called M cells that allow for the uptake of antigens ... "Tonsils Make T-Cells, Too, Ohio State Study Shows". Ohio State University. Ohio State University, Comprehensive Cancer Center. ...
Esophageal squamous cell cancer. Over-expression. 47%. Immunohistochemistry. [24]. Renal cell carcinoma. Under-expression. 100% ... "Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma". J Surg ... "Increased expression of SET domain containing proteins and decreased expression of Rad51 in different renal cell carcinomas". ... "Association of BRCA1 with Rad51 in mitotic and meiotic cells". Cell. 88 (2): 265-75. doi:10.1016/s0092-8674(00)81847-4. PMID ...
Small-cell carcinoma. *Soft-tissue sarcoma. *Spinal tumor. *Squamous cell carcinoma. *Stomach cancer ...
"Identification of genes differentially expressed in human primary lung squamous cell carcinoma". Lung Cancer. 56 (3): 307-17. ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... Cell. 154 (2): 452-64. doi:10.1016/j.cell.2013.06.022. PMC 3717207 . PMID 23870131. "Infection and Immunity Immunophenotyping ( ... "Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells". The Journal of Biological Chemistry ...
It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to ... Cell death may be instigated in the meibomian glands,[30][55] hypothalamic cells,[56] hippocampus cells[57][58] and-important ... programmatic cell death) in various cells in the body. ... suppresses hippocampal cell survival in mice". Annals of the ... Nelson AM, Gilliland KL, Cong Z, Thiboutot DM (October 2006). "13-cis Retinoic acid induces apoptosis and cell cycle arrest in ...
Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer ... Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III ... EAU guidelines on renal cell carcinoma: the 2010 update. In: European Urology. Band 58, 2010, S. 398-406, doi:10.1016/j.eururo. ... nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis. In: Cancer Cell. Band 1, Nr. 2, März 2002, S. ...
O குருதி வகையானது squamous cell carcinoma வருவதற்கான சூழிடர் 14% குறைவாகவும், basal cell carcinoma வருவதற்கான சூழிடர் 4% ... Dean L (2005). "Chapter 5: The ABO blood group.". Blood Groups and Red Cell Antigens. பார்த்த நாள் 2007-03-24. ... Laura Dean, MD (2005). Blood Groups an Red Cell Antigens. National Center for Biotechnology Information, United States ... குறிப்பாக, எச்.ஐ.வி உருவாக்கும் உயிரணு வரிசைகளில் (HIV-producing cell lines) வெளிப்படுத்தப்படும் குருதிவகை ...
... including head-and-neck and cervical squamous cell cancers, radiation treatment is preferably completed within a certain amount ... 2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV. The GEC ESTRO handbook of brachytherapy. Belgium ... Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ...
Asia concluded that regularly eating pickled vegetables roughly doubles a person's risk for esophageal squamous cell carcinoma ... Nevertheless, it was known that yeast extracts can ferment sugar even in the absence of living yeast cells. While studying this ... "Alcoholic fermentation is an act correlated with the life and organization of the yeast cells, not with the death or ... found that sugar was fermented even when there were no living yeast cells in the mixture,[10] by an enzyme complex secreted by ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt ... The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the ... However, such encapsulation tends to prevent immune cells from attacking bacteria in the pus, or from reaching the causative ...
Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common ... The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other ... "Squamous Carcinoma and Intraepithelial Neoplasia of the Conjunctiva - The Eye Cancer Network". Retrieved 2010-03-10.. ... large cell lymphoma of the B-cell type, although T cell lymphomas have also been described. ...
Squamous cell carcinoma. *Tibial dyschondroplasia. *Toxoplasmosis. This poultry article is a stub. You can help Wikipedia by ... Eggs are candled to determine the condition of the air cell, yolk, and white. Candling detects bloody whites, blood spots, or ...
Squamous cell carcinoma of the oral cavity, pharynx and larynx. *Oral cancer ...
Mostly these are squamous cell carcinomas.[17][18]. Food debris, desquamated epithelial cells and bacteria often form a visible ... The tongue is equipped with many taste buds on its dorsal surface, and each taste bud is equipped with taste receptor cells ... Chemicals that stimulate taste receptor cells are known as tastants. Once a tastant is dissolved in saliva, it can make contact ... Distinct types of taste receptor cells respectively detect substances that are sweet, bitter, salty, sour, spicy, or taste of ...
... basal cell carcinoma, squamous cell carcinoma).. *Hypothyroidism (an under-active thyroid) and the side effects of its related ... Lei M, Chuong CM (2016). "STEM CELLS. Aging, alopecia, and stem cells". Science. 351 (6273): 559-60. Bibcode:2016Sci...351.. ... The condition also presents as a side effect of chemotherapy - while targeting dividing cancer cells, this treatment also ... Proteolysis of collagen leads to elimination of the damaged cells and then to terminal hair follicle miniaturization. ...
Non-small-cell lung carcinoma. *Squamous-cell carcinoma. *Adenocarcinoma (Mucinous cystadenocarcinoma). *Large-cell lung ... Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. ... Goblet cell carcinoid[edit]. Main article: Goblet cell carcinoid. This is considered to be a hybrid between an exocrine and ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ...
鱗狀細胞癌(英语:Squamous-cell thyroid carcinoma). *良性 *甲狀腺腺瘤(英语:Thyroid adenoma) ... 甲狀腺癌(惡性):上皮細胞(英语:Thyroid epithelial cell)癌 *乳突性(英语:Papillary thyroid cancer) ... 濾泡性(英语:Follicular thyroid cancer)/何氏細胞(英语:Hurthle cell)(
Squamous cell lung carcinoma[edit]. Main article: Squamous cell carcinoma of the lung ... Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ... The most common types of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, but there are several ... Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC ...
The oropharynx is lined by non-keratinised squamous stratified epithelium.. The HACEK organisms (Haemophilus, Actinobacillus ... the vertebrate pharynx is unique in that it gives rise to endoskeletal support through the contribution of neural crest cells.[ ... Nasopharyngeal carcinoma. *Pharyngeal aspiration. *Pharyngeal consonant. *Pharyngeal (disambiguation). *Saccopharynx, a genus ... the laryngopharynx serves as a passageway for food and air and is lined with a stratified squamous epithelium. It is innervated ...
squamous cell carcinoma. *basal cell carcinoma. *merkel cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
"Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". The ... "Molecular Biology of the Cell. 17 (10): 4212-9. PMC 1635342. . PMID 16870703. doi:10.1091/mbc.E06-04-0318. الوسيط ,التاريخ=. تم ...
Squamous-cell carcinoma of the vagina. *Botryoid rhabdomyosarcoma. *Clear cell adenocarcinoma of the vagina ...
Promoter hypermethylation of MLH1 occurs in 48% of non-small-cell lung cancer squamous cell carcinomas. Promoter ... In head and neck squamous cell carcinomas at least 15 DNA repair genes have frequently hypermethylated promoters; these genes ... genes is associated with expression of immune checkpoints and an inflammatory signature in squamous cell carcinoma of the head ... doi:10.1016/j.cell.2011.04.024. PMID 21620139.. *^ Saxonov S, Berg P, Brutlag DL (2006). "A genome-wide analysis of CpG ...
"Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma". The Journal of Biological Chemistry. 280 ( ... Lorimer DD, Benya RV (May 1996). "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human ...
A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. ... A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. ... thymus squamous cell carcinoma. Go to external page http://purl.obolibrary.org/obo/MONDO_0003493 Copy ...
Carcinoma arising from squamous epithelial cells, morphologically characterized by proliferation of atypical, often pleomorphic ... Squamous cell carcinoma arising from the pleura after pneumonectomy for squamous cell carcinoma of the lung. American Journal ... Primary pleural squamous cell carcinoma (SCC) is a very rare pleural malignancy which has seldom been reported. Cases of ... Faiz S., Allen T.C. (2018) Primary Squamous Cell Carcinoma, Pleural. In: Allen T.C., Suster S. (eds) Pathology of the Pleura ...
CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein. Recently, CD109 emerges as... ... Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. ... Squamous cell carcinoma (SCC), also known as prickle cell carcinoma, is one of the leading causes of cancer-related death in ... Lung squamous cell carcinoma (LSCC) is one of the major subtypes of non-small-cell lung cancer (NSCLC), and accounts for ...
... in squamous cells that line the moist, mucosal surfaces inside the head and neck.] ... A head and neck carcinoma that has_material_basis_ ... Synonyms: squamous cell carcinomas of head and neck, carcinoma ... A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and ... squamous cell carcinoma of the head and neck ... cell_carcinoma url:http://www.cancer.gov/cancertopics/factsheet ...
The biopsy says squamous cells but the tumor marker CA9-19 is very elevated raising suspicions... ... squamous cell carcinoma sunanda To Dr.Fernando Roque, Sir, I have certain doubts regarding my mothers biopsy and clinical ... squamous cell carcinoma. To Dr.Fernando Roque, Sir, I have certain doubts regarding my mothers biopsy and clinical tests. The ... If the squamous carcinoma comes from the lung, gemcitabine is useful, but if it came from some other organ such as the cervix, ...
... is a health condition involving the uncontrolled growth of abnormal cells in the skin outer squamous cells of the epidermis. It ... occurs as a result of keratinization of the epidermal cells and has the potential to metastasize to other regions of the body. ... Squamous cell carcinoma is the second most common type of skin cancer, after basal cell carcinoma. ... What is Squamous Cell Carcinoma?. News-Medical. https://www.news-medical.net/health/What-is-Squamous-Cell-Carcinoma.aspx. ( ...
Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Explore symptoms, inheritance, ... Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. Squamous cells are found in the ... medlineplus.gov/genetics/condition/head-and-neck-squamous-cell-carcinoma/ Head and neck squamous cell carcinoma. ... Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat. ...
Squamous Cell Carcinoma (SCC). Overview. Squamous cell carcinoma (SCC) is a cancer that forms in squamous cells. Squamous cells ... Squamous cell carcinoma commonly occurs in areas of skin with high sun exposure such as the face, scalp, head, neck, ears, ... When squamous cell carcinoma is diagnosed, the physician determines the extent (stage) of the disease by evaluating the depth ... Anyone can develop squamous cell carcinoma; however, certain Individuals have an increased risk. ...
S. E. Edge, D. R. Byrd, C. C. Compton et al., "Cutaneous squamous cell carcinoma and other cutaneous carcinomas," in AJCC ... S. K. Barksdale, N. OConnor, and R. Barnhill, "Prognostic factors for cutaneous squamous cell and basal cell carcinoma. ... Molecular Markers in Cutaneous Squamous Cell Carcinoma. Anthony P. Tufaro,1,2 Jim C.-M. Chuang,2 Nijaguna Prasad,3 Alice Chuang ... M. Alam and D. Ratner, "Cutaneous squamous cell carcinoma," New England Journal of Medicine, vol. 344, no. 13, pp. 975-983, ...
Squamous cell carcinomas can be found in many parts of the body including the lungs, skin, anus, esophagus, head ... Definition Squamous cell carcinoma is a type of skin cancer containing squamous cells. ... The appearance of squamous cell carcinoma is more varied than basal cell carcinoma. Squamous cell carcinoma also tends to grow ... Squamous cell carcinoma is a type of skin cancer containing squamous cells. ...
Squamous cell lung carcinoma is a type of non-small cell lung cancer. Well tell you all about treatments, staging, symptoms, ... about 30 percent are squamous cell carcinomas.. Squamous cell lung carcinoma begins in the top layer of cells, called squamous ... Squamous cell lung carcinoma diagnosis. To diagnose squamous cell lung carcinoma, your doctor will first ask you about your ... Squamous cell lung carcinoma treatment. Treatment for squamous cell lung carcinoma depends on how advanced the cancer is, your ...
NMSC includes basal cell carcinoma and squamous cell carcinoma (SCC), with SCCs constituting approximately 20% of all NMSCs. In ... Light blue cells, initiated cells containing ras and/or p53 mutations; dark blue cells, metastatic cells; thin arrow, inducer; ... Primary care: cutaneous squamous-cell carcinoma. N. Engl. J. Med. 344:975-983. View this article via: CrossRef PubMed Google ... A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl. Acad. Sci. U. S. A. 88: ...
... squamous cell carcinoma, squamous epithelium, stabbing pain, staples, stomach, stool, stricture, strictureplasty, submucosa, ... Video Tag: Squamous Cell Carcinoma. SAGES Webinar: Preparing for the ABSITE (December 2016). Webinar Chair: Michael Awad, MD, ... colon carcinoma, colonic polyp, colonoscopic excision, colonoscopy, colorectal carcinoma, colorectal disease, columnar ... white blood cell. Video Authors. Alseidi A, Awad M, Blatnik J, Traugott A. Video Institutions. Ohio State University, Virginia ...
... a carcinoma that arises from squamous epithelium in the skin and sometimes in the mucous membranes. See more. ... scaly epithelial cell, found in organs such as the skin, cervix, oral cavity, larynx, and vulva. Squamous cell carcinoma of the ... A carcinoma that arises from squamous epithelium and is the most common form of skin cancer.cancroid epidermoid carcinoma ... a carcinoma that arises from squamous epithelium in the skin and sometimes in the mucous membranes. ...
If you or your loved one has been diagnosed with squamous cell carcinoma, Memorial Sloan Kettering Cancer Center is ready to ... Signs and Symptoms of Squamous Cell Carcinoma. Squamous cell skin cancers most commonly appear on parts of the body frequently ... The three major types of skin cancer - basal cell carcinoma, squamous cell carcinoma, and melanoma - are distinct entities. ... Squamous Cell Carcinoma More About Squamous Cell Carcinoma Prevention & Risk Factors for Squamous Cell Carcinoma ...
Histopathologic evaluation showed noninvasive squamous cells carcinoma. The present case report evidences the opportunity of ... We report a case of unexpected anal squamous cells carcinoma found in hemorrhoidectomy specimen. The patient had a 3-year ... which may turn into squamous cell carcinomas [6]. Unexpected anal carcinoma, found after hemorrhoidectomy, is a very rare ... Unexpected Anal Squamous Cells Carcinoma after Open Hemorrhoidectomy. Navarra Luca. ,1 Abruzzese Valentina. ,2 Sista Federico. ...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in ... encoded search term (Cutaneous Squamous Cell Carcinoma) and Cutaneous Squamous Cell Carcinoma What to Read Next on Medscape ... Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin ... Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma. JAMA Dermatol. 2016 May ...
Squamous cell carcinoma: Causes. What causes squamous cell carcinoma?. The cause of most squamous cell carcinoma (SCC) of the ... Skin cancer: Squamous cell carcinoma causes. Types and treatment Common types Basal cell Squamous cell Melanoma Merkel cell ... When mutations develop in skin cells called squamous cells, we get squamous cell carcinoma of the skin.. ... As these cells pile up, a tumor develops.. When a tumor forms in skin cells called squamous cells, we get SCC of the skin. ...
Reserved for tumors with pure squamous histology (dont confuse them with urothelial carcinoma showing squamous differentiation ... Renal Cell Carcinomas * Clear Cell Renal Cell Carcinoma * Clear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade ... Home Education AUAUniversity Education Products & Resources Pathology for Urologists Urinary Bladder Non-urothelial Carcinomas ... Verrucous carcinoma is well differentiated with "pushing" border in lamina propria.. *Staging is similar to urothelial ...
Squamous cell carcinoma is the second most common type of skin cancer. If you are seeking treatment for it, contact Moffitt ... When detected and treated early, squamous cell carcinomas (together with basal cell carcinomas, the other type of nonmelanoma ... Most squamous cell carcinomas develop in parts of the skin that are regularly exposed to the sun, such as the neck, hands, arms ... Squamous cell carcinoma is the second most common type of skin cancer. As the name suggests, this type of cancer develops in ...
Over all, 95% to 98% of squamous cell carcinomas can be cured if they are treated early. Once a squamous cell carcinoma has ... Squamous cells are small, flat skin cells in the outer layer of skin. When these cells become cancerous, they typically develop ... Most cases of squamous cell carcinoma occur in people who have spent lots of time in the sun-especially those with fair skin ... Squamous cell skin carcinoma usually appears as a tiny, painless bump or patch. The skin around it can be red and swollen. The ...
Adenoid squamous cell carcinoma Basaloid squamous cell carcinoma Clear-cell squamous cell carcinoma Spindle-cell squamous cell ... Verrucous squamous cell carcinoma (code 8051/3) Papillary squamous cell carcinoma (code 8052/3) Squamous cell carcinoma (code ... Signet ring-cell squamous cell carcinoma (occasionally rendered as signet ring-cell squamous cell carcinoma) is a histological ... Small-cell keratinizing squamous cell carcinoma (code 8073/3) Spindle-cell squamous cell carcinoma (code 8074/3) It is also ...
There are many treatments available for advanced cutaneous squamous cell carcinoma. Fatigue, nausea, skin changes, and weakness ... Steps to Take If Your Advanced Cutaneous Squamous Cell Carcinoma Treatment Stops Working. Medically reviewed by Yamini Ranchod ... 12 Tips for Managing Side Effects of Advanced Cutaneous Squamous Cell Carcinoma Treatments. Medically reviewed by Yamini ... Today there are more treatments than ever to manage advanced cutaneous squamous cell carcinoma (CSCC). These therapies are very ...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in ... encoded search term (Cutaneous Squamous Cell Carcinoma) and Cutaneous Squamous Cell Carcinoma What to Read Next on Medscape ... Increased Risk of Cutaneous Squamous Cell Carcinoma After Vismodegib Therapy for Basal Cell Carcinoma. JAMA Dermatol. 2016 May ... Cutaneous squamous cell carcinoma and other cutaneous carcinomas. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer; ...
Cutaneous squamous cell carcinoma (SCC) is a common cancer arising from malignant proliferation of epidermal keratinocytes. The ... Basal cell carcinoma, squamous cell carcinoma and melanoma of the skin: analysis of the Singapore Cancer Registry data 1968-97 ... Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin ... Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. The New Hampshire Skin ...
... is a type of skin cancer that begins in the squamous cells. These cells are the thin, flat cells that make up the epidermis, or ... When certain genetic changes occur in the DNA of any of these cells which cause them to multiply uncontrollably, skin cancer ... Squamous cell carcinoma (SSC) is a type of skin cancer that begins in the squamous cells. These cells are the thin, flat cells ... When certain genetic changes occur in the DNA of any of these cells which cause them to multiply uncontrollably, skin cancer ...
Squamous cell carcinoma is a very common type of skin cancer that is typically benign, especially if it is caught early enough ... Smokers may be more likely to develop squamous cell carcinoma than non-smokers. Squamous cell carcinoma has the potential to ... for a squamous cell carcinoma skin cancer to spread to other organs. Squamous cell carcinoma is not always a skin cancer. It ... In addition to appearing on the skin, squamous cell carcinoma can also attack squamous cells in other parts of the body, like ...
... with squamous cell carcinomas comprising one of the largest subsets. All squamous cell carcinoma lesions are thought to begin ... can also be used to treat squamous cell carcinomas.[citation needed] Squamous cell carcinoma of eye tissues is one of the most ... squamous cell carcinoma. Once a carcinoma becomes invasive, it is able to spread to other organs and cause a metastasis, or " ... Most conjunctival squamous cell carcinomas are removed with surgery. A few selected cases are treated with topical medication. ...
Cutaneous squamous cell carcinoma (SCC) presents with a wide variety of clinical manifestations, including papules, plaques, or ... Evaluation for locoregional and distant metastases in cutaneous squamous cell and basal cell carcinoma ... and Evaluation for locoregional and distant metastases in cutaneous squamous cell and basal cell carcinoma and Treatment and ... Clinical features and diagnosis of cutaneous squamous cell carcinoma (SCC). Authors. Jean Lee Lim, MD. Jean Lee Lim, MD ...
EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma.. Miyazaki T1, Kato H, Fukuchi M, ... by immunohistochemistry with an anti-EphA2 monoclonal antibody in 80 patients with esophageal squamous cell carcinoma (ESCC) ... The observation of small gaps on Western blot analysis of the ESCC cell lines suggests that there may be a mechanism for EphA2 ... EphA2 was expressed at a high level in the ESCC cell lines compared to CHEK-1. EphA2 phosphorylation was demonstrated in all ...
  • Other unusual types of skin cancer include Merkel cell tumors and dermatofibrosarcoma protruberans. (webmd.com)
  • Tumor susceptibility consistently correlated with the level of recruitment of T cells and mast cells, cell types known to support the development of skin tumors in mice. (jci.org)
  • Reserved for tumors with pure squamous histology (don't confuse them with urothelial carcinoma showing squamous differentiation) (image B) & (image C) . (auanet.org)
  • When these cells become cancerous, they typically develop into flat or raised, rounded skin tumors. (womenshealthmag.com)
  • Cats can be afflicted with several types of squamous cell carcinoma tumors, including in the mouth. (petmd.com)
  • In vivo, SCC cells with increased CSL levels gave rise to rapidly expanding tumors, while cells with silenced CSL formed smaller and more differentiated tumors with enhanced inflammatory infiltrate. (jci.org)
  • We screened 60 primary ESC tumors and 20 cultured ESC cell lines for the mutation of the APC gene within a mutation cluster region in exon 15, where the "hot spot" of somatic mutation for colorectal and pancreatic cancers is thought to be. (aacrjournals.org)
  • Given that this type of cancer arises from squamous cells, tumors can develop anywhere that these cells are present. (vcahospitals.com)
  • If left untreated, squamous cell carcinoma can develop into large tumors and spread to nearby lymph nodes, a direct link to your immune system. (sharecare.com)
  • Recently, Lango MN 13 found that GRPR is overexpressed in both head and neck squamous cell carcinoma (HNSCC) tumors and adjacent normal mucosa from HNSCC patients compared with levels in control mucosa from individuals without cancer. (nature.com)
  • Genomic profiling of lung squamous cell carcinomas (SCC) has identified NRF2 pathway alterations, which activate oxidative response pathways, in one third of tumors. (sigmaaldrich.com)
  • They wanted to find out if skin stem cells had properties than made them more prone to develop tumors than non-stem cells, said Andrew White, a post-doctoral fellow in Lowry's lab and first author of the study. (healthcanal.com)
  • The study also shows that the further-differentiated progeny of these stem cells, the transit amplifying (TA) cells, are unable to generate squamous cell tumors. (cancernetwork.com)
  • range, 39-83) diagnosed at their institution with penile squamous cell carcinoma who had primary tumors or metastatic lesions sufficient for whole-exome sequencing. (healio.com)
  • Also, we showed that the tumor mutation burden in penile squamous cell carcinoma is similar to other squamous tumors where immune checkpoint inhibitors have been approved as part of the systemic therapies available for advanced disease," he said. (healio.com)
  • These studies demonstrate substantial heterogeneity of in situ binding between and within individual squamous cell tumors. (aacrjournals.org)
  • The squamous cell carcinoma is often one of the most heart-breaking tumors any living thing can develop. (marvistavet.com)
  • The mutational spectrum of aggressive cutaneous squamous cell carcinoma contains a signature of exposure to UVB, which should aid in the definitive diagnosis for squamous tumors and metastases with ambiguous site of origin. (aacrjournals.org)
  • The biopsy says squamous cells but the tumor marker CA9-19 is very elevated raising suspicions like pancreatic or colon cancer.The chemotherapy started was gemcitabine (1 gm). (medhelp.org)
  • NOTCH1 , and CDKN2A , function as tumor suppressors, which means they normally keep cells from growing and dividing too rapidly or in an uncontrolled way. (medlineplus.gov)
  • When tumor suppressors are impaired, cells can grow and divide without control, leading to tumor formation. (medlineplus.gov)
  • Cancer cells grow as a mass (tumor) that may also invade other tissues or spread to other parts of the body. (innerbody.com)
  • Curettage and electrodesiccation involves scraping away the tumor and applying electricity to destroy residual cancer cells. (innerbody.com)
  • As the cells multiply, they form a mass called a tumor. (webmd.com)
  • In this stage, there are cancer cells in the sputum, but a tumor can't be found. (healthline.com)
  • Here, we show that D6-deficient mice have increased susceptibility to cutaneous tumor development in response to chemical carcinogenesis protocols and, remarkably, that D6 deletion is sufficient to make resistant mouse strains susceptible to invasive squamous cell carcinoma. (jci.org)
  • As these cells pile up, a tumor develops. (aad.org)
  • When a tumor forms in skin cells called squamous cells, we get SCC of the skin. (aad.org)
  • Grading is based on degree of differentiation, which roughly correlates with the amount of keratin produced by the tumor cells (image D) . (auanet.org)
  • This condition is called squamous cell carcinoma in situ, and it is diagnosed when the tumor has not yet penetrated the basement membrane or other delimiting structure to invade adjacent tissues. (wikipedia.org)
  • The absence of surface changes should raise suspicion of a metastatic focus from another skin or nonskin primary site or of a different and potentially more lethal tumor, such as a Merkel cell carcinoma . (medscape.com)
  • This procedure involves removing anywhere from a few layers of skin from the top of the affected area to a larger section of the tumor, depending on the size of the carcinoma. (knowcancer.com)
  • A squamous cell carcinoma of the lung is a type of metastasizing tumor that arises from the squamous epithelium in the lung cavity. (petmd.com)
  • After consultation with a veterinary oncologist, chemotherapy may be advised for your cat, especially if the presence of tumor cells is suspected. (petmd.com)
  • A squamous cell carcinoma (SCC) can be described as a malignant and particularly invasive tumor that takes hold in the scale like cells of the epithelium - the tissue that covers the body or lines the cavities of the body. (petmd.com)
  • Notch 1/2 genes play tumor-suppressing functions in squamous cell carcinoma (SCC), a very common malignancy in skin and internal organs. (jci.org)
  • My husband has a squamous cell carcinoma tumor on his neck the size of a tennis ball. (earthclinic.com)
  • It is a malignant tumor of squamous epithelium (epithelium that shows squamous cell differentiation). (medicalxpress.com)
  • Description - Cutaneous squamous cell carcinoma or actinic keratosis is a malignant tumor of epidermal cells in which cells show differentiation in keratinocytes (it is the major constituent of the epidermis , constituting 95% of the cells found there). (wearethecure.org)
  • Squamous cell carcinoma ( SCC ) is a tumor of skin cells. (vcahospitals.com)
  • FNA involves taking a small needle with a syringe and suctioning a sample of cells directly from the tumor and placing them on a microscope slide. (vcahospitals.com)
  • The defective cells multiply rapidly and cause a tumor to form. (healthcommunities.com)
  • Indeed, SEL1L plays a role in breast and pancreatic tumor growth and aggressiveness, possibly involving cell-matrix interactions. (aacrjournals.org)
  • Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. (nature.com)
  • Double labeling with AE1/AE3 and S100 showed striking localized proximity of the spindle-cell melanocytic and keratinocyte components in some areas of this tumor. (biomedsearch.com)
  • Adult stem cells are long-lived and can acquire mutations that can cause cancer, but they also have intrinsic properties for self-renewal that are similar to cancer that could make them more tumor prone," White said. (healthcanal.com)
  • Lowry and his team delivered genetic hits - adding an oncogene that is known to cause cancer and removing a tumor suppressor gene - to the hair follicle stem cells and the transit amplifying cells in two groups of mice and waited to see which developed cancer. (healthcanal.com)
  • Koontongkaew S: The tumor microenvironment contribution to development, growth, invasion and metastasis of head and necksquamous cell carcinomas. (spandidos-publications.com)
  • Jung DW, Che ZM, Kim J, Kim K, Kim KY and Williams D: Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. (spandidos-publications.com)
  • Today, we'll discuss an equal opportunity tumor, squamous cell carcinoma, which unfortunately occurs in both our canine and feline friends. (gopetplan.com)
  • Cytokeratins are expressed in varying combination in the course of differentiation of epithelial cells and tumor cells. (biomedsearch.com)
  • SAN FRANCISCO - Characterization of genomic alterations in penile squamous cell carcinoma revealed involvement of multiple cancer genes that likely contribute to tumor development, as well as a genomic profile that appears similar to other HPV-related squamous cell carcinomas, according to study results presented at Genitourinary Cancers Symposium. (healio.com)
  • All eight of these also are significantly mutated in other squamous cell carcinoma tumor types, according to the researchers. (healio.com)
  • Before reviewing some of the more classical presentations of this tumor, let us address what squamous cells are. (marvistavet.com)
  • May act as a protease inhibitor to modulate the host immune response against tumor cells. (antibodies-online.com)
  • CheckMate -141 is a Phase 3, open-label, randomized trial that evaluated Opdivo versus investigator's choice of therapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) with tumor progression within six months of platinum therapy in the adjuvant, primary, recurrent or metastatic setting. (businesswire.com)
  • The mutational spectrum of cSCC is similar to that of head and neck squamous cell carcinoma and dominated by tumor-suppressor genes. (aacrjournals.org)
  • If cancers cells are present at the tissue edge, additional tissue is removed. (innerbody.com)
  • The vast majority of skin cancers are basal cell carcinomas and squamous cell carcinomas. (webmd.com)
  • These cancers can be described based on how differentiated the cells are - well-differentiated, moderately differentiated, and poorly differentiated. (healthcentral.com)
  • Squamous cell cancers are considered superficial when the upper part of the dermis is involved and infiltrative when the lower dermis and fat tissues under the skin (subcutaneous) are invaded. (healthcentral.com)
  • According to the American Cancer Society , most (about 80 percent) of all lung cancers are non-small cell. (healthline.com)
  • The majority of squamous cell skin cancers are easily and successfully treated with current therapies. (mskcc.org)
  • This is where most skin cancers, including squamous cell skin cancer, arise. (mskcc.org)
  • Squamous cell skin cancers most commonly appear on parts of the body frequently exposed to the sun, such as the face, neck, ears, lips, and neck. (mskcc.org)
  • Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
  • Past studies show that nearly 95 percent of all nonmelanoma skin cancers are the direct result of DNA changes that occur in the skin after cells are damaged by UVA or UVB rays, and scientists continue to investigate the possible causes of the remaining 5 percent. (moffitt.org)
  • This is part of the non-melanoma skin cancers that comprise basal cell carcinoma, Merkel cell carcinoma, and squamous cell carcinoma. (ajmc.com)
  • The word cutaneous is a clinical term that means "related to the skin" and is used to distinguish cSCC from other squamous cell cancers, like certain types of head and neck cancers, and lung cancers. (sharecare.com)
  • These findings provide new insights into driving oncogenic events in a subset of lung squamous cancers, and recommend future clinical studies with FGFR inhibitors in patients with lung and head and neck SCC. (nih.gov)
  • Squamous cancers usually show up in areas most exposed to the sun such as the head, neck, and the back of the hands and forearms, often on sun-damaged skin (roughened, wrinkled, discolored, etc. (straightdope.com)
  • Adding the word "cutaneous" identifies it as a skin cancer and differentiates it from squamous cell cancers that can arise inside the body, in places like the mouth, throat or lungs. (skincancer.org)
  • Likhacheva A, Petit JH, Zaky S, Devlin PM. In Reply to the American Academy of Dermatology Letter Regarding: Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: An American Society for Radiation Oncology Clinical Practice Guideline. (harvard.edu)
  • Although the understanding of the pathogenesis, prevention, and treatment of head and neck cancers has increased over the last decade, no significant improvement has been observed in the survival rates of patients with oral carcinoma, and oral cancer still constitutes a major cause of cancer-associated mortality worldwide 1 . (nature.com)
  • Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide, and esophageal squamous dysplasia (ESD) is the only histopathology that predicts the development of ESCC. (aacrjournals.org)
  • Researchers also found that the progeny of those cells, although just a few divisions away from the mother hair follicle stem cells, were not capable of forming squamous cell cancers. (healthcanal.com)
  • Further studying why those progeny, called transit amplifying cells, can't develop cancer could provide vital clues to how squamous cell cancers originate, said William Lowry, an assistant professor of molecular, cell and developmental biology in Life Sciences and senior author of the study. (healthcanal.com)
  • It had been suggested in the literature that squamous cell cancers could arise from the hair follicle, but it was not clear what cell type within the follicle was responsible. (healthcanal.com)
  • This is the first time two distinct cell types in the skin have been compared and contrasted for their ability to develop squamous cell cancers, said Lowry, who is a Jonsson Cancer Center and Broad Stem Cell Research Center scientist. (healthcanal.com)
  • It was surprising that the progeny of these stem cells, which are developmentally more restricted, could not develop cancers when the mother stem cells could," said Lowry. (healthcanal.com)
  • A type of non-melanoma skin cancer, these cancers form in squamous cells, thin, flat cells found on the surface of the skin, the lining of the hollow organs of the body and the passages of the respiratory and digestive tracts. (healthcanal.com)
  • It appears that these TA cells cannot be stimulated by the oncogenic Ras protein, providing a molecular explanation for their inability to form squamous cell cancers. (cancernetwork.com)
  • Further studying why these TA cells can't develop cancer could provide vital clues to how squamous cell cancers originate,' said William Lowry, the senior author of the study. (cancernetwork.com)
  • A significant amount of research indicates that the cyclooxygenase/prostaglandin E2 (PGE2) pathway of inflammation contributes to the development and progression of a variety of cancers, including squamous cell carcinoma of the oral cavity and oropharynx (OSCC). (mdpi.com)
  • Using fluorescence immunohistochemical techniques, we provide data on the presence, distribution, and levels of EF5 binding as a surrogate for hypoxia in human head and neck and uterine cervix squamous cell cancers (SCCs). (aacrjournals.org)
  • John O'Donnell, Ph.D., M.A., vice president, head, Health Economics and Outcomes Research, Bristol-Myers Squibb, commented, "At Bristol-Myers Squibb, we are committed to improving outcomes in advanced cancers and are proud to apply our Immuno-Oncology science to study the way people live with squamous cell carcinoma of the head and neck. (businesswire.com)
  • Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
  • Actinic keratosis and basal cell carcinoma are easily excised and have a very good prognosis, while cSCC has a poor prognosis, especially if it invades the lymph nodes and adjacent vital structures. (medscape.com)
  • of those, approximately 80% were basal cell carcinoma (BCC) and 20% were cSCC. (medscape.com)
  • Today there are more treatments than ever to manage advanced cutaneous squamous cell carcinoma (CSCC). (healthline.com)
  • The initial presentation of cutaneous squamous cell carcinoma (cSCC) typically includes a history of a nonhealing ulcer or abnormal growth in a sun-exposed area (see the image below). (medscape.com)
  • An overview of cutaneous squamous cell carcinoma (CSCC), including diagnosis, distinguishing CSCC from head and neck cancer, and risk factors for developing advanced disease. (ajmc.com)
  • Cutaneous squamous cell carcinoma [CSCC] is a malignancy of the skin that starts in the squamous cells of the skin. (ajmc.com)
  • I think it's important for healthcare providers to understand that there are great differences that exist between skin CSCC and head and neck squamous cell cancer. (ajmc.com)
  • It is also known as cutaneous squamous cell carcinoma (cSCC). (sharecare.com)
  • In most cases of cSCC, the cancerous cells only occur in the skin, but this type of cancer can metastasize. (sharecare.com)
  • For Groups 1 to 4, the primary objective of this study is to estimate the clinical benefit of cemiplimab monotherapy for patients with: metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC. (clinicaltrials.gov)
  • Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. (aacrjournals.org)
  • This is also called carcinoma in situ. (healthline.com)
  • Three carcinomas in situ are associated with SCCs of the penis: Bowen's disease presents as leukoplakia on the shaft. (wikipedia.org)
  • Squamous cell carcinoma in situ (Bowen disease). (medscape.com)
  • A biopsy can determine whether the carcinoma was in situ, meaning that it would only attack the surface layers - or invasive, with the potential to spread. (wisegeek.com)
  • But, is it as effective for Squamous cell carcinoma in situ (bowen's disease)? (earthclinic.com)
  • Of note, dysplasia not otherwise specified (NOS) and moderate dysplasia risks were similar, as were risks for carcinoma in situ and severe dysplasia. (aacrjournals.org)
  • In dysplastic lesions and carcinomata in situ, a quantitative, as well as qualitative decrease of the CK 4- and CK 17-expression with a heterogeneous expression pattern for CK 17 was found. (biomedsearch.com)
  • Two patients with laryngeal squamous cell carcinoma, presenting with a prelaryngeal abscess, are described. (springer.com)
  • A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck. (ebi.ac.uk)
  • Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat. (medlineplus.gov)
  • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. (medlineplus.gov)
  • Mountzios G, Rampias T, Psyrri A. The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact. (medlineplus.gov)
  • Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes," Cancer , vol. 106, no. 5, pp. 1078-1083, 2006. (hindawi.com)
  • High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma," Cancer Research , vol. 56, no. 16, pp. 3630-3633, 1996. (hindawi.com)
  • Squamous cell carcinomas can be found in many parts of the body including the lungs, skin, anus, esophagus, head and neck areas, and cervix. (healthcentral.com)
  • Whereas, head and neck mucosal squamous cell carcinomas are oftentimes related to smoking, tobacco use, or alcohol abuse. (ajmc.com)
  • Where we think of primary head and neck squamous cell carcinomas being treatable either with surgery or chemoradiation, cutaneous squamous cell carcinoma is managed with surgery in many cases, followed by adjuvant radiation. (ajmc.com)
  • JNK1/2 is inactivated in a substantial proportion of human LSCC and JNK1/2 activities positively correlates with survival rates of lung, cervical and head and neck squamous cell carcinoma patients. (nih.gov)
  • Mutations in the HRAS (m HRAS ) proto-oncogene occur in 4%-8% of patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). (nih.gov)
  • Squamous cell carcinomas, such as squamous head and neck cancer, are treated with a combination of radio-therapy and a therapeutic agent that reduces the amount of hsp27 in the squamous cancer cells. (freepatentsonline.com)
  • All eight of these genes are found to be substantial drivers in head and neck squamous cell carcinoma , and five in cervical squamous cell carcinoma. (healio.com)
  • Recent evidence emerged that NOTCH1 loss-of-function mutation can be successfully targeted in NOTCH1 -mutated head and neck squamous cell carcinoma. (healio.com)
  • Overall, these studies suggest that clinical trials for this disease may benefit from insights gained in head and neck cancer and certain other more common squamous sites, Chahoud said. (healio.com)
  • (5) . Using polarographic needle electrodes, a relationship was demonstrated between the pO 2 in fixed lymph node metastases from head and neck carcinomas and response to radiation therapy. (aacrjournals.org)
  • Findings point to potential interest of squamous cell carcinoma antigen SERPINB3 (show SERPINB3 ELISA Kits )/B4 for the stratification of head and neck squamous cell carcinoma (HNSCC) patients in the therapeutic context. (antibodies-online.com)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE: BMY) announced today new patient-reported quality-of-life data from an exploratory endpoint in the pivotal Phase 3 CheckMate -141 trial evaluating Opdivo in patients with recurrent or metastatic squamous cell carcinoma of the head and neck after platinum therapy compared to investigator's choice of therapy (methotrexate, docetaxel or cetuximab). (businesswire.com)
  • Papillary squamous cell carcinoma is a rare variant of squamous cell carcinoma of the aerodigestive tract that has been correlated with a more favorable prognosis than conventional squamous cell carcinoma of the head and neck. (ebscohost.com)
  • Cases of squamous cell carcinoma arising from the pleura in patients with a chronically draining empyema cavity have rarely been reported. (springer.com)
  • In the United States, approximately 700,000 cases of squamous cell carcinoma are diagnosed each year and the incidence has been following an upward trend. (news-medical.net)
  • Most cases of squamous cell carcinoma occur in people who have spent lots of time in the sun-especially those with fair skin and blue eyes. (womenshealthmag.com)
  • Although researchers know what causes many cases of squamous cell carcinoma - most notably, excessive exposure to ultraviolet radiation - studies are still underway to determine how this type of cancer develops in parts of the body that are seldom or never exposed to sunlight. (moffitt.org)
  • The Skin Cancer Foundation estimates that around one million cases of squamous cell carcinoma is diagnosed each year, with an average of 8,000 cases of death associated with this kind of cancer every year. (consumerhealthdigest.com)
  • Loss of an adhesion molecule called E-cadherin (protein present in the cells involved with the binding in other cells) induces these damaged epithelial cells to attack surrounding tissues. (wearethecure.org)
  • A carcinoma that derives_from squamous epithelial cells. (bioontology.org)
  • The cells that line many of the surfaces of our bodies are called epithelial cells. (gopetplan.com)
  • The cells that line these are areas are called " epithelial cells " and then can take many shapes depending on if their job is to protect us from the environment (skin), absorb material from the environment (GI tract), or perform some other sort of job (respiratory tract. (marvistavet.com)
  • Epithelial cells also line our body cavities, the outside of our organs and blood vessels, forming a thin casing. (marvistavet.com)
  • Squamous " epithelial cells are flat plate-like cells which form layers, a sort of a microscopic armor against the wear and tear that comes from interfacing with the environment. (marvistavet.com)
  • Squamous cell carcinoma arising from the pleura after pneumonectomy for squamous cell carcinoma of the lung. (springer.com)
  • If the squamous carcinoma comes from the lung, gemcitabine is useful, but if it came from some other organ such as the cervix, this chemotherapy may be less effective. (medhelp.org)
  • Squamous cell lung carcinoma is a subtype of non-small cell lung cancer. (healthline.com)
  • Squamous cell lung carcinoma begins in the top layer of cells, called squamous cells, that line the large airways ( bronchi ) of the lung. (healthline.com)
  • There are four subtypes of squamous cell lung carcinoma. (healthline.com)
  • Of all the types of non-small cell carcinomas, squamous cell lung carcinomas have the strongest connection to smoking. (healthline.com)
  • Squamous cell lung carcinoma starts in the cells lining the bronchi. (healthline.com)
  • Of all the causes of squamous cell lung cancer, smoking is by far the most important. (healthline.com)
  • When associated with the lung, it is typically a centrally located large-cell cancer (nonsmall-cell lung cancer). (wikipedia.org)
  • It often has a paraneoplastic syndrome causing ectopic production of parathyroid hormone-related protein, resulting in hypercalcemia, but paraneoplastic syndrome is more commonly associated with small-cell lung cancer. (wikipedia.org)
  • JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression. (nih.gov)
  • Mechanisms of lung squamous cell carcinoma (LSCC) development are poorly understood. (nih.gov)
  • Squamous cell carcinoma of the lung is a non-small cell carcinoma which originate in the bronchi. (wikiversity.org)
  • A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung SCC) has recently been reported, enabling the identification of genomic events that contribute to the oncogenesis of this disease. (nih.gov)
  • We present a case of LGI1 encephalitis only partially responsive to immunotherapy with eventual complete resolution after resection of a squamous cell lung carcinoma. (medworm.com)
  • NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma. (sigmaaldrich.com)
  • In cancer cells, decreased expression of DJ-1 enhances apoptosis in prostate ( 10 ) and lung cancer cells ( 9 , 11 ). (aacrjournals.org)
  • This is the first report of systematic immunohistochemical (ABC-method) investigations concerning the expression of different cytokeratin types (KL 1, CK 4, 10 and 17) within the transformation of the bronchial mucosal epithelium with epithelial hyperplasia to potential preneoplasia and early squamous cell carcinoma of the lung. (biomedsearch.com)
  • Squamous cell carcinoma (SCC), also known as prickle cell carcinoma, is one of the leading causes of cancer-related death in worldwide. (springer.com)
  • Squamous cell carcinoma is the second most common type of skin cancer, after basal cell carcinoma. (news-medical.net)
  • Squamous cell carcinoma is a cancer that arises from particular cells called squamous cells. (medlineplus.gov)
  • Squamous cell carcinoma (SCC) is a cancer that forms in squamous cells. (innerbody.com)
  • When squamous cell carcinoma is diagnosed, the physician determines the extent (stage) of the disease by evaluating the depth of the cancer and whether it has spread. (innerbody.com)
  • Cryosurgery involves the use of liquid nitrogen to freeze and destroy cancer cells. (innerbody.com)
  • Photodynamic therapy (PDT) uses a chemical and special light to destroy cancer cells. (innerbody.com)
  • Cancer occurs when normal cells undergo a transformation and grow and multiply without normal controls. (webmd.com)
  • Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis," Genes Chromosomes and Cancer , vol. 46, no. 7, pp. 661-669, 2007. (hindawi.com)
  • Squamous cell carcinoma is a type of skin cancer containing squamous cells. (healthcentral.com)
  • Squamous cell carcinoma (SCC) is the second most common form of skin cancer . (healthcentral.com)
  • It's classified based on how the cancer cells look under a microscope. (healthline.com)
  • A carcinoma that arises from squamous epithelium and is the most common form of skin cancer. (dictionary.com)
  • Systemic therapy travels through the bloodstream to reach and destroy cancer cells all over the body. (cancer.ca)
  • Then the area is treated with an electrical current to destroy any remaining cancer cells. (cancer.ca)
  • It uses high-energy rays or particles to destroy cancer cells. (cancer.ca)
  • It uses a light-sensitive drug (photosensitizer) and a special type of light to destroy cancer cells. (cancer.ca)
  • The three major types of skin cancer - basal cell carcinoma , squamous cell carcinoma, and melanoma - are distinct entities. (mskcc.org)
  • At Memorial Sloan Kettering, our doctors can successfully diagnose and treat squamous cell skin cancer . (mskcc.org)
  • The mutated cells, which are cancer cells, can multiple quickly. (aad.org)
  • Do some people have a higher risk of developing squamous cell carcinoma skin cancer? (aad.org)
  • As the name suggests, this type of cancer develops in the squamous cells, which are found in the top layers of the skin. (moffitt.org)
  • When detected and treated early, squamous cell carcinomas (together with basal cell carcinomas, the other type of nonmelanoma skin cancer) have a survival rate of more than 95 percent. (moffitt.org)
  • At Moffitt Cancer Center, we take a comprehensive, multispecialty approach to diagnosing and treating squamous cell carcinoma. (moffitt.org)
  • People with a weakened immune system are at especially high risk of developing squamous cell cancer. (womenshealthmag.com)
  • Freezing cancer cells with a chemical called liquid nitrogen. (womenshealthmag.com)
  • As a leader in squamous cell carcinoma research, Moffitt Cancer Center is actively involved in studies to determine the precise DNA changes that cause cancer to develop in skin cells, including those that are not subjected to UVA or UVB exposure. (moffitt.org)
  • Squamous cell carcinomas (SCCs), also known as epidermoid carcinomas, comprise a number of different types of cancer that result from squamous cells. (wikipedia.org)
  • Esophageal cancer may be due to either esophageal squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). (wikipedia.org)
  • Most bladder cancer is transitional cell, but bladder cancer associated with schistosomiasis is often SCC. (wikipedia.org)
  • Squamous Cell Carcinoma, well differentiated, left upper paraspinal back marked for biopsy with adjacent actinic keratosis Squamous Cell Carcinoma, left lateral canthus marked for biopsy Squamous Cell Carcinoma, left ventral forearm Cancer can be considered a very large and exceptionally heterogeneous family of malignant diseases, with squamous cell carcinomas comprising one of the largest subsets. (wikipedia.org)
  • All SCC lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics. (wikipedia.org)
  • Accumulation of these cancer cells causes a microscopic focus of abnormal cells that are, at least initially, locally confined within the specific tissue in which the progenitor cell resided. (wikipedia.org)
  • Cutaneous squamous cell carcinoma (SCC) is a common cancer arising from malignant proliferation of epidermal keratinocytes. (uptodate.com)
  • Squamous cell carcinoma (SSC) is a type of skin cancer that begins in the squamous cells. (thedailystar.net)
  • When certain genetic changes occur in the DNA of any of these cells which cause them to multiply uncontrollably, skin cancer occurs. (thedailystar.net)
  • Squamous cell carcinoma is an extremely common form of skin cancer which is usually benign, especially if caught early. (wisegeek.com)
  • EdRick - It is unusual, but not impossible, for a squamous cell carcinoma skin cancer to spread to other organs. (wisegeek.com)
  • Squamous cell carcinoma is not always a skin cancer. (wisegeek.com)
  • Cancer can be considered a very large and exceptionally heterogeneous family of malignant diseases, with squamous cell carcinomas comprising one of the largest subsets. (wikipedia.org)
  • Those most at risk for developing squamous cell carcinoma are men, those with fair skin, and those with a personal history of cancer. (knowcancer.com)
  • Because their skin has a dramatically reduced ability to repair damage from ultraviolet light, people who have the rare genetic disorder xeroderma pigmentosum have a much higher risk of developing skin cancer of all kinds, including squamous cell carcinoma. (knowcancer.com)
  • The most effective and appropriate treatment for squamous cell carcinoma depends on the size and location of the problem area, as well as whether or not the cancer has metastasized. (knowcancer.com)
  • Curettage and electrodesiccation, where the cancer is scraped away with a spoon-like surgical instrument and the surgical wound is cauterized with electricity to kill off remaining cancer cells. (sharecare.com)
  • Photodynamic therapy (PDT) , which uses a light-activated drug to destroy cancer cells. (sharecare.com)
  • The surgeon will also remove some healthy tissue around the growth, to ensure that all cancer cells have been removed. (sharecare.com)
  • The surgeon stops when they arrive at a layer that shows no cancer cells. (sharecare.com)
  • Radiation therapy may be used a follow-up treatment after excisional surgery, to kill off remaining cancer cells. (sharecare.com)
  • Carcinoma is, by definition, an especially malignant and persistent form of cancer, often returning after is has been excised from the body and metastasizing to other organs and locations on the body. (petmd.com)
  • The spectrum of HPV types found in vulvar squamous cell carcinomas indicates that the efficacy of HPV vaccination in preventing vulvar cancer might be diminished in the studied population, because the recently developed prophylactic vaccines are targeted against a limited number of HPV types. (thedoctorsdoctor.com)
  • I'm currently getting radiation treatment for my basal cell cancer on my nostril. (cancer.org)
  • More advanced cases of carcinoma typically require combination therapy, which includes a combination of two or more of the standard cancer treatments (surgery, radiation therapy, and chemotherapy). (microscopyu.com)
  • The doctor told me there was almost nothing to worry about since squamous cell is one of the least dangerous forms of cancer. (straightdope.com)
  • Diagnosing skin cancer is something you want to leave to the pros, but in general basal cell carcinomas are smooth while the squamous cell kind have a sandpapery feel (squamous means scaly). (straightdope.com)
  • One of the most common forms of skin cancer, squamous cell carcinoma manifests as a thin, flat squamous cell that makes up the outer layer of the skin. (earthclinic.com)
  • Squamous cell carcinoma is a cancer of the skin that generally appears as a thin, flat cell on the outer layer of the skin. (earthclinic.com)
  • Treating skin cancer, even a mild form like squamous cell carcinoma, is crucial for alleviating more serious complications. (earthclinic.com)
  • This compound, obtained from the reaction of cesium hydroxide and hydrochloric acid, is considered a salt that is effective at oxygenating the body and starving the cancer cells. (earthclinic.com)
  • Squamous cell carcinoma is a skin cancer related to squamous cells present in skin which spread as patches.mostly caused due to long exposure durations to uv radiations. (omicsonline.org)
  • Squamous cell carcinoma (SCC) of the skin is the second most common form of skin cancer, characterized by abnormal, accelerated growth of squamous cells . (skincancer.org)
  • Squamous-cell carcinoma or squamous cellular cancer is a cancer of a kind of epithelial cellular, the squamous cellular. (sbwire.com)
  • In cats, about 90% of carcinomas of the toes are actually cancer that had spread to the toe from the lungs. (vcahospitals.com)
  • A highly curable skin cancer, squamous cell carcinoma (pronounced SKWAY-mus sel KAR-sih-NOH-muh) affects the cells that form your skin's outer layer. (sharecare.com)
  • eveloping this common cancer.Also called epidermoid carcinoma, this non-melanoma skin cancer may develop from the skin condition actinic keratosis (pronounced ak-TIH-nik KAYR-uh-TOH-sis), which gives your skin thick, scaly patches. (sharecare.com)
  • However, when caught early, it is very rare for squamous cell carcinoma and its sister skin cancer, basal cell carcinoma, to spread. (sharecare.com)
  • Cutaneous squamous cell carcinoma is the most common form of skin cancer after basal cell carcinoma, with one study estimating up to 700,000 new cases diagnosed each year, accounting for nearly 9,000 deaths. (cityofhope.org)
  • History of skin cancer including basal cell carcinoma (BCC). (skincancer.org)
  • You also have an elevated risk of developing another SCC or basal cell carcinoma (BCC), since sun damage is the primary cause of both forms of skin cancer. (skincancer.org)
  • There are 2 main histopathologic types of esophageal cancer, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). (aacrjournals.org)
  • There is something fundamentally different between the two, and it's important that we figure out why one type of cell was able to develop cancer and the other was not. (healthcanal.com)
  • In this study, Lowry and his team sought to determine which cells of the epidermis, or skin, could give rise to squamous cell cancer. (healthcanal.com)
  • Only the mice that received the genetic hits in the hair follicle stem cell population developed squamous cell cancer. (healthcanal.com)
  • Going forward, White will molecularly profile the hair follicle stem cells and the transit amplifying cells to determine what string of biologic events occur when the cancer-causing genes are delivered. (healthcanal.com)
  • The four-year study was funded by the Jonsson Cancer Center Foundation, a training grant from the California Institute for Regenerative Medicine, the National Institutes of Health, the American Cancer Society, the University of California Cancer Research Coordinating Committee and the Maria Rowena Ross Chair in Cell Biology and Biochemistry. (healthcanal.com)
  • Scientists at UCLA's Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified that squamous cell carcinomas can originate from hair follicle stem cells. (cancernetwork.com)
  • Because permanent treatment and prevention of SCC requires knowledge about the mechanism of transformation and the cell type from which the cancer cell originates, this finding may be very important for developing new strategies to treat and prevent the disease. (cancernetwork.com)
  • Oral cancer include malignancy of the oral cavity and oropharynx, 90% of which are squamous cell carcinoma. (mdpi.com)
  • Ulcerative colitis and Crohn's disease increase the risk of colorectal cancer and gastritis associated with Helicobacter pylori infection has been associated with the development of gastric carcinoma [ 2 , 3 ]. (mdpi.com)
  • Bettendorf O, Piffkò J and Bànkfalvi A: Prognostic and predictive factors in oral squamous cell cancer: important tools for planning individual therapy? (spandidos-publications.com)
  • A. Prayitno, E. Asnar, O. Astirin, D. Rosmala and S. Putra, "Heat Shock Protein 40 (Hsp40) and Hsp70 Protein Expression in Oral Squamous Cell Carcinoma (OSCC)," Journal of Cancer Therapy , Vol. 4 No. 3, 2013, pp. 734-741. (scirp.org)
  • Reduced DJ-1 sensitizes prostate cancer cells toward apoptotic-inducing agents ( 10 ). (aacrjournals.org)
  • We have a very limited understanding of the molecular alterations in penile squamous cell carcinoma , which has been a limitation to the development novel therapeutic strategies," Jad Chahoud, MD, fellow in hematology/medical oncology at The University of Texas MD Anderson Cancer Center, told HemOnc Today . (healio.com)
  • Cutaneous squamous cell carcinoma (SCC) is the second-most-common cancer in Australia. (asm.org)
  • Squamous cell carcinoma is one of the most common forms of skin cancer. (mercy.com)
  • This type of cancer affects the cells that make up your skin's upper layers. (mercy.com)
  • In very minor cases, your doctor can treat squamous cell carcinoma with a topical anti-cancer medication. (mercy.com)
  • Most people with squamous cell carcinoma recover completely following treatment, according to the American Cancer Society. (mercy.com)
  • Treatments can remove the cancer cells completely. (mercy.com)
  • Squamous cell carcinoma is known as a slow-growing cancer that affects the skin. (consumerhealthdigest.com)
  • Treatment options can include the removal of the cancer spot, a method that kills cancer cells through an electric needle, dermabrasion, topical chemotherapy, lymph node surgery and cryosurgery. (consumerhealthdigest.com)
  • While squamous cell carcinoma can usually be treated easily when the condition is picked up in an early stage, prolonging treatment can cause several side-effects due to the growth of the cancer. (consumerhealthdigest.com)
  • Millions of patients are diagnosed with squamous cell carcinoma each year and thousands of deaths are caused by this type of cancer. (consumerhealthdigest.com)
  • Transformation of differentiated thyroid cancer into poorly differentiated carcinoma is rare. (ebscohost.com)
  • Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). (nature.com)
  • The effect of ibrutinib, a first-in-class BTK inhibitor, was tested on stem cell-like OSCC tumorspheres. (nature.com)
  • Wound healing, Matrigel invasion, and tumorsphere formation assays, as well as immunofluorescence analysis and flow cytometry, were used to investigate the effects of BTK knockdown (shBTK), ibrutinib, cisplatin, and ibrutinib/cisplatin combination on OSCC cells. (nature.com)
  • shBTK significantly downregulated the stemness markers Nanog, CD133, T cell immunoglobulin-3 (TIM-3), and Krüppel-like factor 4 (KLF4) in SAS tumorspheres and attenuated OSCC cell migration and colony formation. (nature.com)
  • Ibrutinib reduced the number of aldehyde dehydrogenase (ALDH)-rich OSCC cells and reduced tumorsphere formation, migration, and invasion in a dose-dependent manner. (nature.com)
  • These results demonstrate that ibrutinib effectively inhibits the CSCs-like phenotype of OSCC cells through dysregulation of BTK/CD133 signaling. (nature.com)
  • OSCC is particularly aggressive, as evidenced by considerable cell motility, invasiveness, and propensity for metastasis. (nature.com)
  • Oral and oropharyngeal squamous cell carcinoma (OSCC) is a very aggressive neoplasm and is often diagnosed late in the disease. (mdpi.com)
  • Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor prognosis. (springer.com)
  • Pure verrucous carcinoma has better prognosis with no metastatic risk. (auanet.org)
  • Primary squamous cell thyroid carcinoma shows an aggressive biological phenotype resulting in poor prognosis for patients. (wikipedia.org)
  • See 'Treatment and prognosis of cutaneous squamous cell carcinoma' . (uptodate.com)
  • See 'Epidemiology and risk factors for cutaneous squamous cell carcinoma' and 'Evaluation for locoregional and distant metastases in cutaneous squamous cell and basal cell carcinoma' and 'Treatment and prognosis of cutaneous squamous cell carcinoma' . (uptodate.com)
  • EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma. (nih.gov)
  • Lastly, CD3+ T cells were strongly correlated with the number of CD8+ cells and PD-L1 expression.Conclusion: Our findings provide evidence that the TIME profile of OTSSC impacted prognosis. (doaj.org)
  • Serum SCC (show CYP11A1 ELISA Kits )-Ag level was an important predictor for the cervical squamous carcinoma recurrence and prognosis. (antibodies-online.com)
  • Squamous cell carcinoma of the gallbladder (SCCG) is rarer than gallstone ileus and has a poorer prognosis than the more common adenocarcinoma of the gallbladder. (hcplive.com)
  • Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal carcinoma with a poor prognosis. (scirp.org)
  • Squamous cell carcinoma (SCC) is a health condition involving the uncontrolled growth of abnormal cells in the skin outer squamous cells of the epidermis. (news-medical.net)
  • Squamous cells are thin cells found in the most superficial layer of the skin ( epidermis ) and other mucous membranes in the body. (innerbody.com)
  • It arises from the cells that make the protective keratin of the epidermis (keratinocytes). (healthcentral.com)
  • These cells are found in the outermost layer of our skin, which is called the epidermis. (aad.org)
  • These cells are the thin, flat cells that make up the epidermis, or the outermost layer of the skin. (thedailystar.net)
  • In normal skin, new cells (basal cells) are formed at the bottom layer of the epidermis, and are gradually pushed to the surface as they age. (knowcancer.com)
  • One of three main types of cells in the top layer of the skin (the epidermis), squamous cells are flat cells located near the surface of the skin that shed continuously as new ones form. (skincancer.org)
  • It involves the malignant transformation and proliferation of squamous (flat, scaly) cells, which are the most abundant type of cell in the epidermis. (healthcommunities.com)
  • A 46-year-old male developed a multifocal infiltrative squamous cell carcinoma of the lower lip, which also showed sparse melanocyte atypia within the epidermis and an extensive spindle cell proliferation within the dermis, subcutaneous tissues and nerves. (biomedsearch.com)
  • The presentation of squamous cell carcinoma can occur on any area of the body, but is most common in areas that are frequently exposed to ultraviolet (UV) radiation, such as the ears, lips, face, neck, head, arms and legs. (news-medical.net)
  • Most squamous cell carcinomas develop in parts of the skin that are regularly exposed to the sun, such as the neck, hands, arms, lips, ears and face. (moffitt.org)
  • I have had one episode of squamous cell carcinoma on my neck. (wisegeek.com)
  • In some cases, squamous cell carcinomas may appear on the face, ears, neck, hands, or arms as a flat lesion with a scaly crust, or as a raised area on a pre-existing scar or ulcer. (knowcancer.com)
  • My husband has squamous cell, and has had(rad) 8 surgerys one set of chemo didnt work now on to a new chemo he has had his face neck nose bones removed and has tumores on the out side of his face. (cancer.org)
  • Squamous cell carcinomas can be found on any area of the body, including mucous membranes and the genitals, but they most commonly occur in areas frequently exposed to the sun, including the face, scalp, ears, lips, neck and limbs. (euromelanoma.org)
  • citation needed] SCCs arise from squamous cells, which are flat cells that line many areas of the body. (wikipedia.org)
  • Despite making recommendations to the name squamous cellular carcinoma, the SCCs of different whole whole whole whole whole body system websites can show awesome modifications in their presenting signs, natural record, research, and react to treatment. (sbwire.com)
  • Contrary, there was a mostly patchy staining (55% of cases) with peripheral staining of cells in 1-2 layers (100% of cases) in SCCs. (srce.hr)
  • Whether multiple esophageal squamous cell carcinomas (SCCs) in a patient develop through an identical genetic pathway is still unclear. (spandidos-publications.com)
  • The current study uses a mouse model to demonstrate that SCCs can originate from inside the hair follicle stem cell (SC) niche or from the immediate progenitor cells of these stem cells. (cancernetwork.com)
  • Okunaga S, Takasu A, Meshii N, Imai T, Hamada M, Iwai S, Yura Y. Entry of Oncolytic Herpes Simplex Virus into Human Squamous Cell Carcinoma Cells by Ultrasound. (mdpi.com)
  • a carcinoma that arises from squamous epithelium in the skin and sometimes in the mucous membranes. (dictionary.com)
  • This carcinoma attacks the epithelium , the upper layer of the skin. (wisegeek.com)
  • The epithelium has special cells known as squamous cells which are flattened, and in cross-section, they resemble scales. (wisegeek.com)
  • Squamous cell carcinoma develops in the outer layer of the skin (the epithelium), and can eventually spread to other body parts if it is not addressed in a timely manner. (knowcancer.com)
  • The squamous epithelium is the outer layer of the epithelium, consisting of flat, scale-like cells. (petmd.com)
  • A carcinoma derived from stratified squamous epithelium. (harvard.edu)
  • Dysplasias vary from an abnormal epithelium that can closely resemble the normal cells to an epithelium that is so disorganized from the architectural and cytologic point of view that malignancy is clearly evident. (aacrjournals.org)
  • Wilkey JF, Buchberger G, Saucier K, et al: Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1 -oxide-induced dysplasia and neoplasia in murine squamous oral epithelium. (spandidos-publications.com)
  • Actinic keratosis is an area of red or brown, scaly, rough skin, which can develop into squamous cell carcinoma. (webmd.com)
  • Any of various carcinomas that arise from a kind of flat, scaly epithelial cell, found in organs such as the skin, cervix, oral cavity, larynx, and vulva. (dictionary.com)
  • Usually, squamous cell carcinomas look like small, scaly red patches or open sores, although they can also appear as small, raised nodules that crust or bleed. (moffitt.org)
  • The first sign of squamous cell carcinoma is usually a reddened, scaly patch on the skin. (wisegeek.com)
  • Squamous cell carcinomas appear as rough or scaly patches on your skin. (mercy.com)
  • In some cases, squamous cell carcinomas emerge from small, rough lesions called solar or actinic keratosis. (knowcancer.com)
  • Squamous cell carcinomas often originate in actinic keratosis. (euromelanoma.org)
  • Precancerous lesions for squamous cell carcinoma (SCC) are called "actinic keratoses" (AKs). (sharecare.com)
  • Using 55 polymorphic DNA markers covering every autosomal arm except 13p, 21p, and 22p, restriction fragment length polymorphism analysis was performed on 36 esophageal squamous cell carcinomas (ESCs) and their adjacent normal tissue samples. (aacrjournals.org)
  • Kuwabara T, Hiyama T, Tanaka S, Yoshihara M, Arihiro K and Chayama K: Genetic pathways of multiple esophageal squamous cell carcinomas. (spandidos-publications.com)
  • In addition, 36 cases of low-grade squamous intraepithelial lesion (LSIL) in the cervix and 116 cases of cervical high-grade squamous intraepithelial lesion were used for comparison. (thedoctorsdoctor.com)
  • Invasive Keratinizing Squamous Cell Carcinoma of the Endometrium as Extension of Invasive Cervical Squamous Cell Carcinoma. (ebscohost.com)
  • Squamous cell carcinoma of the endometrium, either primary or as an extension of a cervical carcinoma, is extremely rare. (ebscohost.com)
  • EphA2 expression was investigated by immunohistochemistry with an anti-EphA2 monoclonal antibody in 80 patients with esophageal squamous cell carcinoma (ESCC) who had undergone surgery. (nih.gov)
  • EphA2 expression was also investigated in 7 ESCC cell lines (TE-1, -2, -8, -13, -15, TT and TTn) and 1 immortalized human esophageal keratinocyte cell line (CHEK-1). (nih.gov)
  • EphA2 was expressed at a high level in the ESCC cell lines compared to CHEK-1. (nih.gov)
  • Northern blot analysis showed that EphA2 mRNA expression in TE-1 was greater than that in the other ESCC cell lines. (nih.gov)
  • The observation of small gaps on Western blot analysis of the ESCC cell lines suggests that there may be a mechanism for EphA2 regulation at the point of translation. (nih.gov)
  • EphA2 is a potential target to prevent ESCC cells spreading into the lymphatic drainage. (nih.gov)
  • However, its role in esophageal squamous cell carcinoma (ESCC) is unknown. (aacrjournals.org)
  • Esophageal squamous cell carcinoma (ESCC) is common among Asian populations. (aacrjournals.org)
  • Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro, Cell Stress & Chaperones, 2002, pp. 177-185, vol. 7, No. 2. (freepatentsonline.com)
  • There are many ways to treat squamous cell carcinoma that has not spread. (womenshealthmag.com)
  • Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma? (harvard.edu)
  • The data identified the top recurrent mutations in penile squamous cell carcinoma, highlighting NOTCH1 mutations in 35% of patients," Chahoud told HemOnc Today . (healio.com)
  • These data could guide future clinical trials in penile squamous cell carcinoma. (healio.com)
  • Further, research found that TP53 mutations were more common in HPV-negative penile squamous cell carcinoma, occurring in no patients with HPV-positive disease ( P = .03). (healio.com)
  • We would like to validate these findings in a larger cohort and translate these data to the development of clinical trials in patients with penile squamous cell carcinoma in the frontline and relapsed settings," he added. (healio.com)
  • There are several other conditions that may present with similar symptoms to squamous cell carcinoma and require differential diagnosis. (news-medical.net)
  • Medical history, physical examination and medical imaging may suggest a squamous cell carcinoma, but a biopsy for histopathology generally establishes the diagnosis. (wikipedia.org)
  • See 'Clinical features and diagnosis of cutaneous squamous cell carcinoma (SCC)' . (uptodate.com)
  • Studies however revealed that in certain dogs with subungual squamous cell carcinoma there was evidence of pulmonary metastasis at the time of diagnosis. (wearethecure.org)
  • Treatment for cutaneous or skin squamous cell carcinoma - For accurate diagnosis vets depend on microscopic examination of tissue. (wearethecure.org)
  • The diagnosis of squamous cell carcinoma starts with the doctor learning your complete medical history. (mercy.com)
  • it typically arises from mutations in the body's cells that occur during an individual's lifetime. (medlineplus.gov)
  • Through ongoing studies, researchers are also investigating the exact changes that occur within the body after squamous cells are damaged by UV exposure. (moffitt.org)
  • Squamous cell carcinomas occur at least twice as frequently in men as in women. (skincancer.org)
  • However, it can occur anywhere on your body where squamous cells are present - primarily the upper layer of your skin. (mercy.com)
  • A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
  • Once the lesion has grown and progressed to the point where it has breached, penetrated, and infiltrated adjacent structures, it is referred to as "invasive" squamous cell carcinoma. (wikipedia.org)
  • Squamous cell carcinomas usually present as a single, solitary lesion in one location, but there is a kind of SCC called multicentric squamous cell carcinoma (also known as Bowen's disease or Bowenoid carcinoma) that presents as many (two or more) lesions in multiple locations on the body, including the mouth. (vcahospitals.com)
  • Unlike basal cell carcinoma, squamous cell carcinoma looks more like a red, crusted lesion. (sharecare.com)
  • Treatment for squamous cell carcinoma involves total excision of the carcinoma. (wisegeek.com)
  • Surgery is the most common treatment for squamous cell carcinoma. (mercy.com)
  • At Moffitt, we offer a complete range of treatments for squamous cell carcinoma, from Mohs micrographic surgery (offered in conjunction with the USF Department of Dermatology) to targeted radiation therapy. (moffitt.org)
  • Exposure to UV radiation appears to carry the greatest risk of squamous cell carcinoma and is seen as the primary cause of the condition. (news-medical.net)
  • For this reason, people with fair skin living in areas with high sun exposure, such as the predominantly Caucasian population of Australia, are most likely to get squamous cell carcinoma. (news-medical.net)
  • Squamous cells are found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities such as the airways and intestines. (medlineplus.gov)
  • Histopathological characteristics of metastasizing squamous cell carcinoma of the skin and lips," Histopathology , vol. 49, no. 3, pp. 256-264, 2006. (hindawi.com)
  • Squamous cell carcinoma of the skin is associated with sun exposure. (dictionary.com)
  • The following are treatment options for squamous cell carcinoma (SCC) of the skin. (cancer.ca)
  • The cause of most squamous cell carcinoma (SCC) of the skin is well known. (aad.org)
  • Spending time in the sun without protecting your skin from the sun greatly increases your risk of developing squamous cell carcinoma of the skin. (aad.org)
  • Every time UV light hits our skin, it can damage some of the DNA inside our skin's cells. (aad.org)
  • When mutations develop in skin cells called squamous cells, we get squamous cell carcinoma of the skin. (aad.org)
  • Squamous cells are small, flat skin cells in the outer layer of skin. (womenshealthmag.com)
  • Squamous cell skin carcinoma usually appears as a tiny, painless bump or patch. (womenshealthmag.com)
  • Once squamous cell carcinoma develops on the skin, it usually grows slowly. (womenshealthmag.com)
  • If a squamous cell carcinoma develops on your skin, you can limit the damage by detecting the problem early. (womenshealthmag.com)
  • As old cells die, they are pushed to the surface of the skin by the new cells developing underneath. (moffitt.org)
  • Abnormal cells can accumulate without dying off and create bumps or sores on the skin. (moffitt.org)
  • These cells form on the surface of the skin, on the lining of hollow organs in the body, and on the lining of the respiratory and digestive tracts. (wikipedia.org)
  • In addition to appearing on the skin, squamous cell carcinoma can also attack squamous cells in other parts of the body, like internal organs, the tongue, and so forth. (wisegeek.com)
  • The biggest risk factor for squamous cell carcinoma, along with other skin conditions like basal cell carcinoma and melanoma , is pale skin and frequent sun exposure. (wisegeek.com)
  • The term "squamous cell" refers to the flat, scale-like cells that comprise the surface of the skin, the linings of hollow internal organs, and the inner passages of the digestive and respiratory systems. (knowcancer.com)
  • Squamous cell carcinoma may affect any of these areas, but it is most commonly seen on the outer layer of the skin. (knowcancer.com)
  • Although most squamous cell carcinomas appear on parts of the skin that are exposed to the sun, they may also be found in the mouth, anus, or genitals. (knowcancer.com)
  • When DNA damage occurs, though, this process can be disturbed, causing the squamous cells in the next deepest layer of skin to grow out of control. (knowcancer.com)
  • People whose immune systems are weakened by disease and/or use of immunosupressants are also at higher-than-average risk for squamous cell carcinoma, as are individuals who have large scars, skin infections or inflammatory skin diseases like psoriasis. (knowcancer.com)
  • In cases where it is important to absolutely minimize the amount of skin that is removed, doctors may use Moh's surgery, a process where the affected skin is removed layer by layer until all afflicted cells are gone. (knowcancer.com)
  • In addition to the outer layers of the skin, squamous cells are found in the inner linings of the airways, hollow organs, and parts of the digestive tract. (sharecare.com)
  • Squamous cell carcinoma (SCC) and keratoacanthoma (KA) are skin neoplasms of epithelial origin. (srce.hr)
  • As shown in the illustration, the skin is made up of several layers of cells with the squamous layer at the top. (vcahospitals.com)
  • Exposure to papilloma-like viruses also appears to contribute to multicentric SCC in the mouth and other areas of the skin where squamous cells are present. (vcahospitals.com)
  • Like basal cell carcinoma, squamous cell carcinoma is usually present in sun-exposed areas of the skin, can appear quickly, bleed, be sore and may not heal. (sharecare.com)
  • This is a precedent-setting, pivotal trial that could finally establish a standard of care for advanced squamous cell carcinoma of the skin," said one of the study's investigators at City of Hope, dermatologist Badri Modi, M.D . "It's part of the immunotherapy revolution. (cityofhope.org)
  • Squamous cell carcinoma (SCC) of the skin is caused by DNA damage that leads to abnormal changes (mutations) in the squamous cells in the outermost layer of skin. (skincancer.org)
  • Squamous cells are flat scale-like cells in the upper layers of the skin. (sciencephoto.com)
  • These cells cover the surfaces and line the cavities that interact with the outside world, whether that be the skin, mouth, digestive system or respiratory system. (gopetplan.com)
  • Squamous cells are a normal type of epithelial cell, and make up the outer layer of our skin, mouth and nose. (gopetplan.com)
  • UV radiation damages the DNA in your skin, causing the cells to start growing out of control. (mercy.com)
  • Avoiding tanning beds, limiting sun exposure at the time of day when the sun is the brightest, wearing protective clothing and sunscreen and alerting your doctor to any skin changes can go a long way in preventing squamous cell carcinoma. (mercy.com)
  • Your doctor will perform a physical exam and look at your skin for signs of squamous cell carcinoma. (mercy.com)
  • The results of the test will determine if the cells are squamous cell carcinoma or another skin condition. (mercy.com)
  • The squamous cells make up the outer layer of the skin, nose, and mouth. (marvistavet.com)
  • It develops within the squamous cells within the skin. (consumerhealthdigest.com)
  • These cells are found in the outer and middle layer of the skin. (consumerhealthdigest.com)
  • Poorly Differentiated Squamous Cell Carcinoma Arising in Tattooed Skin. (ebscohost.com)
  • The presence of a poorly differentiated squamous cell carcinoma in an old tattooed skin is of interest as it has not been previously. (ebscohost.com)
  • It is well known that squamous cell carcinoma of the esophagus arises from a series of preinvasive lesions or intraepithelial neoplasia. (aacrjournals.org)
  • We analyzed 35 patients with squamous cell carcinoma of the esophagus and found that, contrary to the surrounding normal epithelia, dysplastic and neoplastic cells expressed appreciable levels of the gene. (aacrjournals.org)
  • Faiz S., Allen T.C. (2018) Primary Squamous Cell Carcinoma, Pleural. (springer.com)
  • Non-invasive carcinoma may also be referred to as Bowen's disease. (news-medical.net)
  • A large, ulcerated, invasive squamous cell carcinoma of the left lower eyelid. (medscape.com)
  • Your veterinarian will palpate your cat's lymph nodes to check for swelling - an indication that the body is fighting an invasive disease, and a sample of the lymph fluid will be taken to test for the presence of cancerous cells. (petmd.com)
  • Squamous cell carcinomas have been divided into a superficially invasive type and invasive type. (thedoctorsdoctor.com)
  • VIN is found adjacent to 60-80% of superficially invasive squamous cell carcinomas and 25% of deeply invasive carcinomas. (thedoctorsdoctor.com)
  • Tumuluri V, Thomas GA and Fraser IS: Analysis of the Ki-67 antigen at the invasive tumour front of human oral squamous cell carcinoma. (spandidos-publications.com)
  • We report a case of invasive keratinizing squamous cell carcinoma of the cervix, in which there was replacement of the entire endometrial cavity by an intraepithelial and. (ebscohost.com)
  • basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma . (webmd.com)
  • There are three main types: basal cell carcinoma, squamous cell carcinoma, and melanoma. (straightdope.com)
  • Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip. (biomedsearch.com)
  • We report on a case of the collision of a desmoplastic-neurotropic melanoma and a squamous cell carcinoma on the lip. (biomedsearch.com)
  • To our knowledge, this is the first report of the collision of a squamous cell carcinoma and desmoplastic-neurotropic melanoma. (biomedsearch.com)
  • It occurs as a result of keratinization of the epidermal cells and has the potential to metastasize to other regions of the body. (news-medical.net)
  • SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the squamous cells. (skincancer.org)
  • Squamous cell carcinoma of conjunctiva is rare6 among which pigmented squamous cell carcinoma is very rare.7 It occurs chiefly at limbus and spread over surface and into fornices rarely penetrate the globe. (ebscohost.com)
  • When the body can no longer repair all the damage, changes called mutations develop in our skin's cells. (aad.org)
  • Using cell culture and xenograft models, we show that several of these mutations drive cellular transformation. (nih.gov)
  • squamous cell carcinoma To Dr.Fernando Roque, Sir, I have certain doubts regarding my mother's biopsy and clinical tests. (medhelp.org)
  • incisional biopsy revealed squamous cell carcinoma. (medscape.com)
  • Most doctors like to ensure that the margins are clean, and they may take a biopsy to confirm that the patient had squamous cell carcinoma, and that the carcinoma has been fully removed. (wisegeek.com)
  • Since squamous cell carcinoma can metastasize, (spread to other parts of the body) people who experience any of the symptoms described above are usually advised by their doctors to undergo a biopsy as quickly as possible. (knowcancer.com)
  • They did a biopsy and said it was Squamous Cell Carcinoma. (cancer.org)
  • aspiration suggested: a squamous cell carcinoma whereas needle core biopsy favoured an undifferentiated carcinoma of probable thyroid. (ebscohost.com)
  • However, there are still debates on the clinical value of induction chemotherapy for patients with advanced and resectable oral squamous cell carcinoma. (clinicaltrials.gov)
  • The hypothesis of this study is that the induction chemotherapy of TPF (docetaxel, cisplatin, and 5-fluorouracil) protocol could benefit the patients with locally advanced oral squamous cell carcinoma. (clinicaltrials.gov)
  • Dissanayaka WL, Pitiyage G, Kumarasiri PV, Liyanage RL, Dias KD and Tilakaratne WM: Clinical and histopathologic parameters in survival of oral squamous cell carcinoma. (spandidos-publications.com)
  • Wangsa D, Ryott M, Avall-Lundqvist E, et al: Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma. (spandidos-publications.com)
  • Jerjes W, Upile T, Petrie A, et al: Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients. (spandidos-publications.com)
  • Wang Z, Zhang B, Jiang L, et al: RACK1, an excellent predictor for poor clinical outcome in oral squamous carcinoma, similar to Ki67. (spandidos-publications.com)
  • Rivera MCA: 4NQO carcinogenesis: A model of oral squamous cell carcinoma. (spandidos-publications.com)
  • Fuentes B, Duaso J, Droguett D, et al: Progressive extracellular matrix disorganization in chemically induced murine oral squamous cell carcinoma. (spandidos-publications.com)
  • Rivera CA, Droguett DA, Kemmerling U and Venegas BA: Chronic restraint stress in oral squamous cell carcinoma. (spandidos-publications.com)
  • Whether oncolytic herpes simplex virus type 1 (HSV-1) can be introduced into oral squamous cell carcinoma (SCC) cells through membrane pores remains undetermined. (mdpi.com)
  • Retrieved on January 20, 2020 from https://www.news-medical.net/health/What-is-Squamous-Cell-Carcinoma.aspx. (news-medical.net)
  • Smokers may be more likely to develop squamous cell carcinoma than non-smokers. (wisegeek.com)
  • Up to eighty percent of transplant patients eventually develop squamous cell carcinomas. (knowcancer.com)
  • Human Papillomavirus (HPV) Profiles of Vulvar Lesions: Possible Implications for the Classification of Vulvar Squamous Cell Carcinoma Precursors and for the Efficacy of Prophylactic HPV Vaccination. (thedoctorsdoctor.com)
  • To analyze the impact of HPV profiles of vulvar precancerous lesions for their classification and to assess the presumable efficacy of the prophylactic HPV vaccination, 269 vulvar excisions representing lichen sclerosus, lichen simplex chronicus, condylomata acuminata, d-VIN, all grades of u-VIN and squamous cell carcinomas were subjected to the HPV typing by use of GP5+/6+ polymerase chain reaction and reverse line blot hybridization. (thedoctorsdoctor.com)
  • We conclude that the original VIN terminology proposed in 1986 seems to be appropriate for the classification of vulvar squamous dysplastic lesions. (thedoctorsdoctor.com)
  • Cytokeratin expression in preneoplastic lesions and early squamous cell carcinoma of the bronchi. (biomedsearch.com)
  • CK 10 was expressed only in early squamous cell carcinoma of the bronchus, and CK 17 in varying quantity in hyperplastic, preneoplastic and cancerous lesions of the bronchial mucosa. (biomedsearch.com)
  • Our results reveal an increasing expression of squamous epithelial type-cytokeratins (CK 4, CK 17) in hyperplastic and metaplastic lesions of the bronchial mucosa. (biomedsearch.com)
  • Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. (uptodate.com)
  • While surgery remains the standard of care for treatment of squamous cell carcinoma when it is possible, he wonders whether there is a role for immunotherapy to be combined with surgery to reduce the rate of disease relapse and metastasis. (cityofhope.org)
  • Also, while the damage has probably already been done, I'd skip any future sunbathing - squamous cell carcinoma appears to be directly related to solar exposure. (straightdope.com)
  • Degradation of the cell cycle and the proliferation of malignant cells results in the loss of control mechanisms that ensure the normal function of tissues. (spandidos-publications.com)
  • Errors in protein folding result in a new homeostasis or inhibition of apoptosis and increasing cell proliferation that triggers carcinogenesis. (scirp.org)
  • Proliferation and migration were upregulated in TE-15 cells treated with an miR-150 inhibitor. (wiley.com)
  • MSK's squamous cell carcinoma experts, including Mohs surgeon Erica Lee, are focused on your needs and concerns when planning care. (mskcc.org)
  • It was diagnosed as squamous cell carcinoma and removed with Mohs surgery . (cityofhope.org)
  • As squamous cell carcinoma is a relatively common condition with potentially serious outcomes, there have been considerable public health and educational campaigns in recent decades to reduce the incidence of the disease. (news-medical.net)
  • The peak incidence of squamous cell carcinoma in the dog is between 6 and 10 years of age. (wearethecure.org)
  • Short, coated dogs that spend a long time outdoors, also have a higher incidence of squamous cell carcinoma. (wearethecure.org)
  • SCC forms in squamous cells, the lining of hollow organs, and within the respiratory and digestive tracts. (cancernetwork.com)
  • The direct cause of squamous cell carcinoma is damage to DNA, which typically results from prolonged exposure to UV rays from the sun or commercial tanning beds. (knowcancer.com)
  • Squamous cell carcinomas that afflict the genitals are often caused by exposure to Human papilloma-virus (HPV). (knowcancer.com)
  • Typically a result of extended exposure to ultraviolet radiation, squamous cell carcinoma is highly preventable and also treatable. (earthclinic.com)
  • Squamous cell carcinoma may be caused by high exposure to the sunlight. (sciencephoto.com)
  • The main cause of squamous cell carcinoma is exposure to UV radiation over time. (mercy.com)
  • Viral infection was hardly established without the adsorption step, but plaque number was increased by the exposure of HSV-1-inoculated cells to ultrasound. (mdpi.com)
  • Scanning electron microscopy revealed depressed spots on the cell surface after exposure to ultrasound. (mdpi.com)
  • Secretory carcinoma is slow-growing, so it doesn't always respond well to chemotherapy. (healthline.com)
  • Squamous cell carcinoma of the vulva progresses through similar stages as squamous cell carcinoma of the cervix and vagina. (thedoctorsdoctor.com)
  • A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. (ebi.ac.uk)
  • Primary pleural squamous cell carcinoma (SCC) is a very rare pleural malignancy which has seldom been reported. (springer.com)
  • Primary pleural squamous cell carcinoma misdiagnosed as localized mesothelioma: A case report and review of the literature. (springer.com)
  • Hypercalcaemia in primary squamous cell carcinoma of the stomach. (ebscohost.com)
  • Primary squamous cell carcinoma of the stomach is said to be an extremely rare case. (ebscohost.com)
  • Less than 80 cases of primary squamous cell carcinoma of the stomach have been published. (ebscohost.com)
  • Primary squamous cell carcinoma of the thyroid gland: A case report and role of radiotherapy. (ebscohost.com)
  • Primary squamous cell carcinoma is an extremely rare tumour of the thyroid gland. (ebscohost.com)
  • A case of an elderly lady who was diagnosed to have primary squamous cell carcinoma of the thyroid gland is presented and the role of radiotherapy is discussed. (ebscohost.com)
  • citation needed] Squamous cell carcinoma of eye tissues is one of the most frequent neoplasms of cattle. (wikipedia.org)