Carcinoma small cell. Medical search

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.

A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Tumors or cancer of the LUNG.

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).

A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.

Diamond. A crystalline form of carbon that occurs as hard, colorless or tinted isomeric crystals. It is used as a precious stone, for cutting glass, and as bearings for delicate mechanisms. (From Grant & Hackh's Chemical Dictionary, 5th ed)

A republic in western Africa, south of GUINEA and west of LIBERIA. Its capital is Freetown.

A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.

Tumors or cancer of the URINARY BLADDER.

Pathological processes of the URINARY BLADDER.

A substituted carcinogenic nitrosamine.

A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.

Individuals licensed to practice medicine.

The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.

A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

People who frequently change their place of residence.

Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.

Abnormally high level of calcium in the blood.

The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.

A VITAMIN D that can be regarded as a reduction product of vitamin D2.

A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

A cell line derived from cultured tumor cells.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. (1/2496)

Based on an increased frequency of early death (death within the first treatment cycle) in our two latest randomized trials of combination chemotherapy in small-cell lung cancer (SCLC), we wanted to identify patients at risk of early non-toxic death (ENTD) and early toxic death (ETD). Data were stored in a database and logistic regression analyses were performed to identify predictive factors for early death. During the first cycle, 118 out of 937 patients (12.6%) died. In 38 patients (4%), the cause of death was sepsis. Significant risk factors were age, performance status (PS), lactate dehydrogenase (LDH) and treatment with epipodophyllotoxins and platinum in the first cycle (EP). Risk factors for ENTD were age, PS and LDH. Extensive stage had a hazard ratio of 1.9 (P = 0.07). Risk factors for ETD were EP, PS and LDH, whereas age and stage were not. For EP, the hazard ratio was as high as 6.7 (P = 0.0001). We introduced a simple prognostic algorithm including performance status, LDH and age. Using a prognostic algorithm to exclude poor-risk patients from trials, we could minimize early death, improve long-term survival and increase the survival differences between different regimens. We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification. (+info)

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise. (2/2496)

The assessment of symptom palliation is an essential component of many treatment comparisons in clinical trials, yet an extensive literature search revealed no consensus as to its precise definition, which could embrace relief of symptoms, time to their onset, duration, degree, as well as symptom control and prevention. In an attempt to assess the importance of these aspects and to compare different methods of analysis, we used one symptom (cough) from a patient self-assessment questionnaire (the Rotterdam Symptom Checklist) in a large (>300 patient) multicentre randomized clinical trial (conducted by the Medical Research Council Lung Cancer Working Party) of palliative chemotherapy in small-cell lung cancer. The regimens compared were a two-drug regimen (2D) and a four-drug regimen (4D). No differences were seen between the regimens in time of onset of palliation or its duration. The degree of palliation was strongly related to the initial severity: 90% of the patients with moderate or severe cough at baseline reported improvement, compared with only 53% of those with mild cough. Analyses using different landmark time points gave conflicting results: the 4D regimen was superior at 1 month and at 3 months, whereas at 2 months the 2D regimen appeared superior. When improvement at any time up to 3 months was considered, the 4D regimen showed a significant benefit (4D 79%, 2D 60%, P = 0.02). These findings emphasize the need for caution in interpreting results, and the importance of working towards a standard definition of symptom palliation. The current lack of specified criteria makes analysis and interpretation of trial results difficult, and comparison across trials impossible. A standard definition of palliation for use in the analysis of clinical trials data is proposed, which takes into account aspects of onset, duration and degree of palliation, and symptom improvement, control and prevention. (+info)

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (3/2496)

The EPH family is the largest subfamily of receptor protein tyrosine kinases, consisting of the EPHA and EPHB subgroups. Ephrin-B1, ephrin-B2, and ephrin-B3 are ligands of the EPHB subgroup and are encoded by the EFNB1, EFNB2, and EFNB3 genes, respectively. We have shown previously that EPHB2 transcripts are expressed in six small cell lung carcinoma (SCLC) cell lines. In this study, we examined the expression of EPHB1, EPHB2, EPHB3, EPHB4, and EPHB6 in 4 SCLC tumor specimens and 14 cell lines including 3 cell lines derived from these tumor specimens. To investigate whether potential autocrine loops of EPHB receptors and ephrin-B ligands exist in SCLC, the expression of EFNB1, EFNB2, and EFNB3 was also examined. Our data show that transcripts encoding multiple members of the EPHB subgroup and the ephrin-B subgroup are coexpressed in SCLC cell lines and tumors. These results suggest that the EPHB subgroup receptor kinases may modulate the biological behavior of SCLC through autocrine and/or juxtacrine activation by ephrin-B ligands that are expressed in the same or neighboring cells. (+info)

Combined modality therapy of lung cancer. (4/2496)

Combined modality therapy for lung cancer was first demonstrated to be successful in limited-stage small cell lung cancer. Concurrent administration of chemotherapy with chest and elective brain irradiation appears to produce the best results, with cisplatin/etoposide as the core chemotherapy. Using such programs, 2-year survival in the 40% range and 5-year survivals in excess of 20% may be expected, based on the results of multiple studies. Attempts to improve on these results through the use of altered schemes of chest irradiation or the delivery of high-dose consolidation chemotherapy are ongoing but to date have not been shown to affect survival significantly. We remain at a plateau in the effectiveness of combined modality therapy for small cell lung cancer, with little evidence that it impacts survival at all in extensive-stage disease. The incorporation of new agents in combination chemotherapy regimens, more "specific" immunotherapy directed at tumor-associated antigens, and the potential adjunctive use of broad-spectrum neuropeptide antagonists offer promise for the future. In non-small cell lung cancer, the sequential use of platinum-based chemotherapy and chest irradiation appears superior in survival to standard, daily fractionated radiation therapy used alone, with long-term survival increased from 5-10% to 15-20%. Concurrent administration of chemotherapy with cisplatin/etoposide and chest irradiation produces 2-year survival in the range of 30%, about twice that would be expected for radiation therapy alone, but has not been compared to it in the setting of a randomized trial. Low-dose cisplatin on a daily basis has been combined as a "sensitizer" with chest irradiation, producing initial results that appeared encouraging. However, these have not been reproduced in subsequent, randomized trials. Another approach to combined modalities has been to give chemotherapy or chemotherapy/radiation therapy as induction, followed by surgical resection, with or without subsequent additional treatment. Most patients (80-85%) can be resected, with encouraging survival at 2 and 3 years in the Southwest Oncology Group experience (37 and 26%, respectively). However, toxicity is greater, and such an approach is associated with an overall mortality risk in the range of 10%. A current intergroup study attempts to define the role of surgery in this setting. The major recent development that is likely to influence the future of combined modality therapy for this disease is the advent of multiple new chemotherapeutic agents, such as the taxanes, gemcitabine, vinorelbine, and the topoisomerase-I inhibitors, which have activity in stage IV disease. The immediate challenge is how to combine these agents with platinum analogues, radiation, and surgery. Aiding this process may be the use of molecular biological "markers" that may predict the chance of success or failure with a given systemic agent. The next decade is likely to see substantial improvements in the outcome of treatment for patients with stages I-III non-small cell lung cancer, based on the systemic exploration of combined modalities. (+info)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (5/2496)

We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was analysed with high performance liquid chromatography with UV-detection. Plasma collected during drug administration was tested in vitro for growth inhibition of a teniposide-resistant small-cell lung cancer (SCLC) cell line. The predominant toxicities were elevated liver transaminases (maximum common toxicity criteria (CTC) grade 4) and serum creatinine (maximum CTC grade 2). These showed only a limited increase with increasing doses, often recovered during drug administration and were fully reversible. Duration of elevated alanine-amino transferase (ALT) was dose-limiting in one patient at 20 mg m(-2). Other frequent toxicities were grade 1-2 nausea/vomiting, fever and mild fatigue. Mean fostriecin plasma half-life was 0.36 h (initial; 95% CI, 0-0.76 h) and 1.51 h (terminal; 95% CI, 0.41-2.61 h). A metabolite, most probably dephosphorylated fostriecin, was detected in plasma and urine. No tumour responses were observed, but the plasma concentrations reached in the patients were insufficient to induce significant growth inhibition in vitro. The maximum tolerated dose (MTD) has not been reached, because drug supply was stopped at the 20 mg m(-2) dose level. However, further escalation seems possible and is warranted to achieve potentially effective drug levels. Fostriecin has a short plasma half-life and longer duration of infusion should be considered. (+info)

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (6/2496)

A combination chemotherapy of irinotecan (CPT-11) and cisplatin (CDDP) has been reported to be active for lung cancer. In the previous trial, however, diarrhoea and leucopenia became the major obstacle for sufficient dose escalation of CPT-11 to improve the treatment outcome. We conducted a phase I study to investigate whether the fractionated administration of CDDP and CPT-11 at escalated dose was feasible and could improve the treatment outcome. Twenty-four previously untreated patients with unresectable non-small-cell lung cancer (NSCLC) or extensive disease of small-cell lung cancer (SCLC) were eligible. Both CDDP and CPT-11 were given on days 1 and 8, and repeated every 4 weeks. The dose of CDDP was fixed at 60 mg m(-2) and given by 1-h infusion before CPT-11 administration. The starting dose of CPT-11 was 40 mg m(-2), and the dose was escalated by an increase of 10 mg m(-2). The maximally tolerated dose of CPT-11 was determined as 60 mg m(-2) because grade 4 haematological or grade 3 or 4 non-haematological toxicities developed in six patients out of 11 patients evaluated. Diarrhoea became a dose-limiting toxicity. The objective response rates were 76% for NSCLC and 100% for SCLC. The recommended dose of CPT-11 and CDDP in a phase II study will be 50 mg m(-2) and 60 mg m(-2) respectively. (+info)

Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma. (7/2496)

Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and the epitope specificity of these antibodies was characterised. Anti-amphiphysin I antibodies were evaluated by immunohistochemistry on human and rat cerebellum and immunoblots of rat brain homogenates. Serum samples included 134 patients with PND and anti-Hu antibodies (83% had SCLC), 44 with SCLC and PND without anti-Hu-antibodies, 63 with PND and either Yo, Ri, or Tr antibodies, 146 with SCLC without PND, and 104 with non-PND. Positive serum samples were confirmed with immunoblots of recombinant human amphiphysin I and immunoreacted with five overlapping peptide fragments covering the full length of the molecule. Serum samples positive for anti-amphiphysin I antibodies included those from seven (2.9%) patients with PND and two (1.4%) with SCLC without PND. Six of the seven anti-amphiphysin I antibody positive patients with PND had SCLC (three with Hu-antibodies), and one had anti-Hu-antibodies but no detectable tumour. The PND included encephalomyelitis/sensory neuropathy (five patients), cerebellar degeneration (one), and opsoclonus (one). All anti-amphiphysin I antibodies reacted with the C terminus of amphiphysin I, but seven also recognised other fragments of the molecule. In conclusion, anti-amphiphysin I antibodies are present at low frequency in patients with SCLC irrespective of the presence of an associated PND. All anti-amphiphysin I antibody positive serum samples have in common reactivity with the C terminus of the protein. (+info)

Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule. (8/2496)

PURPOSE: To evaluate the efficacy of paclitaxel and carboplatin (PC) in small-cell lung cancer (SCLC) patients resistant to cyclophosphamide, doxorubicin, and etoposide (CDE). PATIENTS AND METHODS: We performed a phase II study with PC in SCLC patients who relapsed within 3 months after first-line treatment with CDE. Paclitaxel administration (175 mg/m2 by a 3-hour intravenous infusion) was followed by a 30-minute infusion of carboplatin (area under the curve 7; Chatelut formula) once every 3 weeks for five cycles. Dexamethasone, clemastine, and ranitidine were standard premedication before every cycle. RESULTS: Included were 35 patients (median age, 59 years; 16 with limited disease and 19 with extensive disease; Eastern Cooperative Oncology Group performance status of < or = 1; median time off treatment 6 weeks) who were previously treated with CDE (n = 33), oral etoposide (n = 2), and reinduction CDE (n = 15); only one patient had received three CDE treatments of five cycles. The CDE regimen was followed by local thoracic radiotherapy in seven patients. Hematologic toxicity of grade 3 or 4, for leukopenia was 27% and 6%, for thrombocytopenia 21% and 13%, and for anemia 17% and 0%, respectively, for a total of 132 cycles. Two patients had neutropenic fever; no toxic death occurred. Nonhematologic toxicity was paresthesia CTC grade 3, diarrhea grade 4, and myalgia grade 3 in one patient each. Reversible paresthesia (CTC grade 1 and 2) in toes and fingers was reported in 69% of patients. Thirty-four patients were assessable for response: complete response in two patients, partial response in 23 patients, stable disease in eight patients, and progressive disease in one patient (response rate, 73.5%; 95% confidence interval, 59% to 88%). One patient was found to have atypical carcinoid at pathologic review and was excluded. Median time to progression was 21 weeks (range, 3 to 40 weeks). Median survival was 31 weeks (range, 6 to 112 weeks). One-year survival was 9%. CONCLUSION: Second-line PC in CDE-resistant SCLC patients yields a high response rate and seems non-cross-resistant to CDE. Toxicity was mild in these poor-prognosis patients. (+info)

Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ... For therapeutic purposes, two broad classes are distinguished: non-small-cell lung carcinoma and small-cell lung carcinoma.[66] ... Small-cell lung carcinoma (SCLC), non-small-cell lung carcinoma (NSCLC)[3]. ...

https://en.wikipedia.org/wiki/Lung_cancer

Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... Micrograph showing the yolk sac component of a mixed germ cell tumour. H&E stain. ... these include leukemia and most forms of carcinoma in situ. Tumor is also not synonymous with cancer. While cancer is by ... a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears ...

https://en.wikipedia.org/wiki/List_of_vaginal_tumors

Small cell carcinoma is a rare (1%) type that cannot be diagnosed using PSA. As of 2009[update] researchers were investigating ... LNCaP cells express AR, but PC-3 and DU-145 cells express very little or no AR. The proliferation of LNCaP cells is androgen- ... Initially, small clumps of cancer cells remain within otherwise normal prostate glands, a condition known as carcinoma in situ ... Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997). "Small-cell carcinoma of the prostate". Journal of the ...

https://en.wikipedia.org/wiki/Prostate_cancer

... fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to ... ISBN 978-0-387-97050-9. Han S, Khuri FR, Roman J (January 2006). "Fibronectin stimulates non-small cell lung carcinoma cell ... The RGD sequence (Arg-Gly-Asp) is located in III10 and is the site of cell attachment via α5β1 and αVβ3 integrins on the cell ... Fibronectin has been implicated in carcinoma development. In lung carcinoma, ...

https://en.wikipedia.org/wiki/Fibronectin

Celiac disease Ulcerative colitis Crohn's disease Hepatic cirrhosis Hepatocellular carcinoma Lung cancer, including small cell ... Mignogna MD, Fortuna G, Satriano AR (December 2008). "Small-cell lung cancer and necrolytic migratory erythema". The New ... Wilkinson DS (1973). "Necrolytic migratory erythema with carcinoma of the pancreas". Transactions of the St. John's Hospital ... swollen epidermal cells and necrosis of the superficial epidermis are most characteristic. Immunofluorescence is usually ...

https://en.wikipedia.org/wiki/Necrolytic_migratory_erythema

... is typically a squamous cell carcinoma. Other types include adenocarcinoma, small cell carcinoma, and melanoma. ... Most anal cancers are squamous cell carcinomas (epidermoid carcinomas), that arises near the squamocolumnar junction. It may be ... Dewdney A, Rao S (2012). "Metastatic squamous cell carcinoma of the anus: time for a shift in the treatment paradigm?". ISRN ... Human papillomavirus: Examination of squamous cell carcinoma tumor tissues from patients in Denmark and Sweden showed a high ...

https://en.wikipedia.org/wiki/Anal_cancer

Small cell lung carcinoma (SCLC) (FDA Oct 2007). As of 2016, experiments were under way for Neuroblastoma, Brainstem glioma, ... Topotecan is often given in combination with Paclitaxel as first line treatment for extensive-stage small-cell lung cancer. ... "FDA Rubber-Stamps APP Pharma's Generic Topotecan for Small Cell Lung and Cervical Cancers". 30 Nov 2010. DNA Topoisomerases and ... In addition, topotecan is experimentally treating Non-small cell lung cancer, Colorectal Cancer, Breast cancer, Non-Hodgkin ...

https://en.wikipedia.org/wiki/Topotecan

NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for ... "Molecular characterization of prostatic small-cell neuroendocrine carcinoma". Prostate. 55 (1): 55-64. doi:10.1002/pros.10217. ... distinguishing small-cell carcinomas from other tumors. GRCh38: Ensembl release 89: ENSG00000111674 - Ensembl, May 2017 GRCm38 ... Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. ...

https://en.wikipedia.org/wiki/Enolase_2

... small cell carcinoma of the prostate, in turn, exhibit a universal type in that virtually all the constituent tumor cells ... June 2006). "Small cell carcinoma of the prostate: an immunohistochemical study". The American Journal of Surgical Pathology. ... Immunohistochemically, prostatic small cell carcinoma are positive for thyroid transcription factor 1 (TTF-1), CD56, ... These types of prostate cancer comprise true neuroendocrine cancers, such as small cell carcinoma, carcinoid and carcinoid-like ...

https://en.wikipedia.org/wiki/Neuroendocrine_differentiation

Ectopic ACTH syndrome, also known as small-cell carcinoma. Ectopic calcification, a pathologic deposition of calcium salts in ... such as small-cell carcinoma, can cause Cushing's syndrome Ectopia lentis, the displacement of the crystalline lens of the eye ...

https://en.wikipedia.org/wiki/Ectopia_(medicine)

Syrian hamsters are a model for researching Non-small-cell lung carcinoma, which is one of the types of human lung cancer. In ... "Current role of surgery in small cell lung carcinoma". Journal of Cardiothoracic Surgery. 4 (1): 30. doi:10.1186/1749-8090-4-30 ... Oral squamous-cell carcinoma is a common cancer in humans and difficult to treat. Scientists studying this disease broadly ... The scientist can take cell samples from the mouth of the hamster to measure the development of the cancer. This process has ...

https://en.wikipedia.org/wiki/Laboratory_Syrian_hamster

Mary A. McClure, 77, American politician, small-cell carcinoma. Carlos Morocho Hernández, 76, Venezuelan WBA and WBC super ... desmoplastic small-round-cell tumor. Sheilla Lampkin, 70, American politician, member of the Arkansas House of Representatives ... Paddy Phelan, 78, English cricketer (Essex). Anita Reeves, 68, Irish actress (Dancing at Lughnasa, Little Gem), cancer. Wolfram ... sumo's small great 'Wolf,' dies Thomas Edward Danson Jr. Tributes paid to renowned poet and vicar Gwynn ap Gwilym Archived ...

https://en.wikipedia.org/wiki/Deaths_in_July_2016

Pleural desmoplastic small round cell tumor (pleural DSRCT). *Pleural synovial sarcoma. *Pleural solitary fibrous tumor ( ... Pleural carcinomas *Pleural mucoepidermoid carcinoma. *Pleural pseudomesotheliomatous adenocarcinoma. See also[edit]. *Pleural ...

https://en.wikipedia.org/wiki/Pleural_disease

Hietanen S, Lain S, Krausz E, Blattner C, Lane DP (2000). "Activation of p53 in cervical carcinoma cells by small molecules". ... However, recent data shows that leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent ... Cell Res. 242 (2): 540-7. doi:10.1006/excr.1998.4136. PMID 9683540. Nishi K, Yoshida M, Fujiwara D, Nishikawa M, Horinouchi S, ... Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation ...

https://en.wikipedia.org/wiki/Leptomycin

"Gefitinib inhibits MUC5AC synthesis in mucin-secreting non-small cell lung cancer cells". Lung Cancer. 50 (1): 19-24. doi: ... A case of suspected lung metastasis of pancreatic carcinoma with bronchorrhea similar to bronchioloalveolar carcinoma]". Nihon ... Kitazaki T, Fukuda M, Soda H, Kohno S (2005). "Novel effects of gefitinib on mucin production in bronchioloalveolar carcinoma; ... Milton D, Kris M, Gomez J, Feinstein M (2005). "Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma ...

https://en.wikipedia.org/wiki/Bronchorrhea

"Expression of dihydrodiol dehydrogenase in the resected stage I non-small cell lung cancer". Oncology Reports. 9 (3): 515-9. ... "Reduction of dihydrodiol dehydrogenase expression in resected hepatocellular carcinoma". Oncology Reports. 10 (2): 271-6. doi: ... Genes to Cells. 5 (2): 111-25. doi:10.1046/j.1365-2443.2000.00310.x. PMID 10672042. S2CID 25136637. Zhang Y, Dufort I, Rheault ... of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells". The ...

https://en.wikipedia.org/wiki/AKR1C1

Choong, Nicholas W. W.; Quevedo, J. Fernando; Kaur, Judith S. (2005-03-15). "Small cell carcinoma of the urinary bladder: The ... "Priming Tissue-specific Cellular Immunity in a Phase I Trial of Autologous Dendritic Cells for Prostate Cancer". Clinical ...

https://en.wikipedia.org/wiki/Judith_Kaur

It was counterproductive in non-squamous non-small-cell lung carcinoma. International Nonproprietary Names for Pharmaceutical ... name Portrazza for use with gemcitabine and cisplatin in previously untreated metastatic squamous non-small-cell lung carcinoma ...

https://en.wikipedia.org/wiki/Necitumumab

... small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported ... "ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung ... encouraging Phase II results for small-cell lung cancer. Dimond PF (9 March 2010). "Antibody-Drug Conjugates Stage a Comeback ... It comprises the CD56-binding antibody, lorvotuzumab (huN901), with a maytansinoid cell-killing agent, DM1, attached using a ...

https://en.wikipedia.org/wiki/Lorvotuzumab_mertansine

... small superficial basal-cell carcinomas (sBCCs) in adults; clinically typical, non-hyperkeratotic, non-hypertrophic actinic ... squamous cell carcinoma in situ), and, secondary to surgery, for basal cell carcinoma, as well as actinic keratosis. Imiquimod ... Imiquimod should be used for treatment of [superficial basal cell carcinoma] only when surgery is medically less appropriate ... Other cell types activated by imiquimod include natural killer cells, macrophages and B-lymphocytes. Imiquimod exerts its ...

https://en.wikipedia.org/wiki/Imiquimod

Poulsen, H; Junge, J; Vyberg, M; Horn, T; Lundvall, F (2003). "Small vulvar squamous cell carcinomas and adjacent tissues. A ... Lichen sclerosus is associated with 3-7% of all cases of vulvar squamous cell carcinoma. In women, it has been reported that ... "Does lichen sclerosus play a central role in the pathogenesis of human papillomavirus negative vulvar squamous cell carcinoma? ... "High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis". British Journal of Dermatology. 145 ...

https://en.wikipedia.org/wiki/Lichen_sclerosus

Small cell carcinoma, a common cause of ACTH secreted ectopically. *Congenital adrenal hyperplasia, diseases in the production ... ACTH acts by binding to cell surface ACTH receptors, which are located primarily on adrenocortical cells of the adrenal cortex ... ACTH also stimulates lipoprotein uptake into cortical cells. This increases the bioavailability of cholesterol in the cells of ... ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of ...

https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone

Increased expression of mir-126 inhibits cell proliferation of non-small cell lung carcinoma cells in vitro and prevents tomour ... "MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines". Biochem Biophys Res Commun. 373 (4): 607-12. doi: ... Sun Y, Bai Y, Zhang F, Wang Y, Guo Y, Guo L (2010). "miR-126 inhibits non-small cell lung cancer cells proliferation by ... This includes controlled cell death and responses to wounds. During apoptosis cell death, cells release apoptotic bodies ...

https://en.wikipedia.org/wiki/Mir-126

... -containing drugs Gefitinib for treatment of non-small-cell lung carcinoma. Lapatinib for treatment of advanced- ... "Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to ... Lapatinib eliminates the growth of breast cancer stem cells that cause tumor growth. The binding of lapatinib to the ATP- ... the cancer stem cell. Archived from the original on 2008-11-26. Nelson MH, Dolder CR (February 2006). "Lapatinib: a novel dual ...

https://en.wikipedia.org/wiki/Quinazoline

Small cell carcinoma Champaneria MC, Modlin IM, Kidd M, Eick GN (2006). "Friedrich Feyrter: a precise intellect in a diffuse ... "Feyrter's cells": Synonym for neuroendocrine cells, also known as "clear cells" or Kultschitzky cells. "Feyrter disease": ...

https://en.wikipedia.org/wiki/Friedrich_Feyrter

... small cell lung carcinoma. Maksym Pashayev, 20, Ukrainian footballer, car accident. Amalia Solórzano, 97, Mexican First Lady ( ...

https://en.wikipedia.org/wiki/Deaths_in_December_2008

Other types of carcinomas are rare and may include small cell, Merkel cell, clear cell, sebaceous cell or basal cell tumors. ... of penile cancers are squamous cell carcinomas. Other types of penile cancer such as Merkel cell carcinoma, small cell ... Around 95% of penile cancers are squamous cell carcinomas. They are classified into the following types: basaloid (4%) warty (6 ... Tis: Carcinoma in situ. Ta: Noninvasive verrucous carcinoma. T1a: Tumor invades subepithelial connective tissue without lymph ...

https://en.wikipedia.org/wiki/Penile_cancer

There is little evidence that it is effective in preventing basal cell carcinoma. Typical use of sunscreen does not usually ... basal-cell carcinoma and squamous-cell carcinoma. Of greatest concern is that the melanoma risk increases in a dose-dependent ... When the cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the tissue is replaced. Sun ... Sunscreen is effective and thus recommended for preventing melanoma and squamous cell carcinoma. ...

https://en.wikipedia.org/wiki/Sunburn

Chronic exposure can increase the incidence of respiratory cancers, including small cell carcinoma. It is one of 13 chemicals ...

https://en.wikipedia.org/wiki/Chloromethyl_methyl_ether

F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ... In F9 cells lacking both β-catenin and plakoglobin, very little E-cadherin and α-catenin accumulated at the cell surface. Mice ... A tumor cell line with defective δ-catenin, low levels of E-cadherin and poor cell-to-cell adhesion could be restored to normal ... Catenin and EMT interactions may also play a role in hepatocellular carcinoma. VEGF-B treatment of hepatoma carcinoma cells can ...

https://en.wikipedia.org/wiki/Catenin

squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Microneedling is a procedure in which an instrument with multiple rows of tiny needles is rolled over the skin to elicit a ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ...

https://en.wikipedia.org/wiki/Acne_vulgaris

Oral carcinoma[edit]. Patients after HSCT are at a higher risk for oral carcinoma. Post-HSCT oral cancer may have more ... Researchers have conducted small studies using non-myeloablative hematopoietic stem cell transplantation as a possible ... who have lost their stem cells after birth. Other conditions[13] treated with stem cell transplants include sickle-cell disease ... Peripheral blood stem cells[26] are now the most common source of stem cells for HSCT. They are collected from the blood ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

... almost all subtypes of renal cell carcinoma, nephrogenic adenomas, ovarian cancer cells, bladder, prostate, and endometrial ... aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present ... regulation of metanephric nephron tubule epithelial cell differentiation. • cell differentiation. • mesonephric tubule ... positive regulation of metanephric DCT cell differentiation. • negative regulation of mesenchymal cell apoptotic process ...

https://en.m.wikipedia.org/wiki/PAX8

... , sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC). ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... May 2012). "Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of ... "Role of afatinib in the treatment of advanced lung squamous cell carcinoma". Clinical Pharmacology. 9: 147-157. doi:10.2147/ ...

https://en.wikipedia.org/wiki/Afatinib

The removal of cells for biopsy, using a needle Clinical features[edit]. Clinical features can be found in the subhyoid portion ... Thyroglossal duct cyst carcinoma[edit]. Rarely, cancer may be present in a thyroglossal duct cyst. These tumors usually arise ... In some individuals, portions of the duct remain behind, leaving small pockets, known as cysts. During a person's life, these ... Thyroglossal cysts can be defined as an irregular neck mass or a lump which develops from cells and tissues left over after the ...

https://en.wikipedia.org/wiki/Thyroglossal_cyst

Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... However, a smaller tumor in an area such as Wernicke's area (small area responsible for language comprehension) can result in a ... Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ...

https://en.m.wikipedia.org/wiki/Brain_tumors

"Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells ... William Figg; Cindy H. Chau; Eric J. Small (14 September 2010). Drug Management of Prostate Cancer. Springer Science & Business ... G. Raspé; W. Brosig (22 October 2013). International Symposium on the Treatment of Carcinoma of the Prostate, Berlin, November ... Cell Biol. 42 (6): 813-27. doi:10.1016/j.biocel.2009.11.013. PMID 19931639.. ...

https://en.m.wikipedia.org/wiki/Antiandrogen

... or tumors such as lymphoma or squamous cell carcinoma. A tonsillolith (also known as a "tonsil stone") is material that ... No crypts, but small folds. Roof of pharynx Tubal tonsils. Ciliated pseudostratified columnar (respiratory epithelium). Roof of ... These M cells then alert the underlying B cells and T cells in the tonsil that a pathogen is present and an immune response is ... The tonsils have on their surface specialized antigen capture cells called M cells that allow for the uptake of antigens ...

https://en.wikipedia.org/wiki/Tonsil

Thus, in most cases, small amounts of BaP are metabolized prior to being passed into the blood.[citation needed] The lungs are ... BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ... In the 18th century a scrotal cancer of chimney sweepers, the chimney sweeps' carcinoma, was already known to be connected to ... BaP has an effect on the number of white blood cells, inhibiting some of them from differentiating into macrophages, the body's ...

https://en.wikipedia.org/wiki/Benzo(a)pyrene

Esophageal squamous cell cancer. Over-expression. 47%. Immunohistochemistry. [24]. Renal cell carcinoma. Under-expression. 100% ... Non-small-cell lung cancer. Over-expression. 29%. Immunohistochemistry. [22]. Soft tissue sarcoma. Over-expression. 95%. ... of non-small cell lung cancers,[45] and 36% of colon cancers.[46] miR-34a is also generally under-expressed in primary ... "High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients". Br. J. ...

https://en.wikipedia.org/wiki/Rad51

Basal cell carcinoma Fleshy, growing mass Areas exposed to the sun Squamous cell carcinoma Unusual growth that is red, scaly or ... Small, firm, round bumps with pits in the center that may sit on tiny stalks Anywhere ... Small red dots on the skin, or larger, bruise-like spots that appeared after taking medicine Anywhere ... Started with a single scaly, red and slightly itchy spot, and within a few days, did large numbers of smaller patches of the ...

https://en.wikipedia.org/wiki/Skin_rash

Hardiman P, Pillay OC, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003, 361 (9371): 1810-2. PMID ... Gynecologic ultrasonography, specifically looking for small ovarian follicles. These are believed to be the result of disturbed ... and interleukin-1 in modulating progesterone and oestradiol production by human luteinized granulosa cells in culture. Hum. ... 12 or more small follicles should be seen in an ovary on ultrasound examination.[52]More recent research suggests that there ...

https://zh.wikipedia.org/wiki/多囊卵巢綜合症

Small intestine cancer. *Small-cell carcinoma. *Soft-tissue sarcoma. *Spinal tumor. *Squamous cell carcinoma ...

https://simple.wikipedia.org/wiki/Category:Cancer

Binding of AMP at this site, corresponding in a change from the T state of the enzyme to the R state, results in small changes ... The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. ... Shimada S, Matsuzaki H, Marutsuka T, Shiomori K, Ogawa M (July 2001). "Gastric and intestinal phenotypes of gastric carcinoma ... In fact, 70% of dimeric phosphorylase in the cell exists as bound to glycogen granules rather than free floating.[9] ...

https://en.wikipedia.org/wiki/Glycogen_phosphorylase

Small lymphocytes 7-8. Large lymphocytes 12-15. *B cells: releases antibodies and assists activation of T cells ... carcinoma ... T cells: *CD4+ helper T cells: T cells displaying co-receptor ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ... CD8+ cytotoxic T cells: T cells displaying co-receptor CD8 are known as CD8+ T cells. These cells bind antigens presented on ...

https://en.wikipedia.org/wiki/Immune_cell

It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to ... It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, ... Cell death may be instigated in the meibomian glands,[30][55] hypothalamic cells,[56] hippocampus cells[57][58] and-important ... programmatic cell death) in various cells in the body. ... suppresses hippocampal cell survival in mice". Annals of the ...

https://en.wikipedia.org/wiki/Isotretinoin

... produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma ... and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells". Molecular Pharmacology. 75 (1): 196-207. ... Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, ... These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated ...

https://en.wikipedia.org/wiki/Autocrine_signalling

Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. In: The New England Journal of Medicine. Band ... Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III ... Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer ... EAU guidelines on renal cell carcinoma: the 2010 update. In: European Urology. Band 58, 2010, S. 398-406, doi:10.1016/j.eururo. ...

https://de.m.wikipedia.org/wiki/Bevacizumab

O குருதி வகையானது squamous cell carcinoma வருவதற்கான சூழிடர் 14% குறைவாகவும், basal cell carcinoma வருவதற்கான சூழிடர் 4% ... The highest frequencies are found in small, unrelated populations. For example, about 80% of the Blackfoot Indians of Montana ... Dean L (2005). "Chapter 5: The ABO blood group.". Blood Groups and Red Cell Antigens. பார்த்த நாள் 2007-03-24. ... Laura Dean, MD (2005). Blood Groups an Red Cell Antigens. National Center for Biotechnology Information, United States ...

https://ta.m.wikipedia.org/wiki/ஏபிஓ_குருதி_குழு_முறைமை

1983). "Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture". Biol Cell. ... resembles the enterocytes lining the small intestine.[2][3] Caco-2 cells express tight junctions, microvilli, and a number of ... Caco-2 cells are most commonly used not as individual cells, but as a confluent monolayer on a cell culture insert filter (e.g ... 2005). "The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell ...

https://en.wikipedia.org/wiki/Caco-2

PTCH1 (Nevoid basal-cell carcinoma syndrome). *BMPR1A (BMPR1A juvenile polyposis syndrome). *IL2RG (X-linked severe combined ... If the pre-treatment testes are very small and there has been a history of undescended testes it might take longer to achieve ... LHCGR (Luteinizing hormone insensitivity, Leydig cell hypoplasia, Male-limited precocious puberty). *FSHR (Follicle-stimulating ... "The Smallest Kid in School: Evaluating Delayed Puberty". Medscape Pediatrics.. *^ a b Jones H, ed. (2008). "Chapter 9: Puberty ...

https://en.wikipedia.org/wiki/Kallmann_syndrome

Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... The small pink spheres represent the location of the active-site threonine residue in each subunit. Light blue chemical ... "Cell. 137 (1): 133-45. doi:10.1016/j.cell.2009.01.041. PMC 2668214. PMID 19345192.. ... Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ...

https://en.m.wikipedia.org/wiki/Proteasome

The common house mold, Trichoderma longibrachiatum, produces small toxic peptides containing amino acids not found in common ... This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction ... "Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment". Environmental Health Perspectives. 118 (6): ... McCormick A, Loeffler J, Ebel F (November 2010). "Aspergillus fumigatus: contours of an opportunistic human pathogen". Cell. ...

https://en.m.wikipedia.org/wiki/Toxic_mold

"Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". ... CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus ... Various types of CD30-positive T cell lymphomas[11]. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor ...

https://en.wikipedia.org/wiki/CD30

Small-cell carcinoma. *Transitional cell carcinoma. Penis. *Carcinoma *Extramammary Paget's disease. *Bowen's disease ... A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a ... Weidner N (February 1999). "Germ-cell tumors of the mediastinum". Seminars in Diagnostic Pathology. 16 (1): 42-50. PMID ... Testicular seminoma originates in the germinal epithelium of the seminiferous tubules.[2] About half of germ cell tumors of the ...

https://en.wikipedia.org/wiki/Seminoma

"Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma". American Journal of Pathology. 134 (6): ... A small pilot study suggested possible benefit from the tyrosine kinase inhibitor erlotinib in people with advanced ... the actual cell of origin is unknown. Recent evidence has suggested that the initial transformed cell that generates the ... Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to normal liver cells (left of image). H&E stain. ...

https://en.m.wikipedia.org/wiki/Cholangiocarcinoma

Treatment of renal cell carcinoma with infliximab resulted in prolonged disease stabilization in certain patients. Etanercept ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ... but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac ... NK cells, neutrophils, mast cells, eosinophils, and neurons.[5] TNFα is a member of the TNF superfamily, consisting of various ...

https://en.wikipedia.org/wiki/TNF-alpha

Due to its anatomy, the pinna largely eliminates a small segment of the frequency spectrum; this band is called the pinna notch ... benign and malignant neoplasm, including tumors, keratoacanthoma, carcinoma[5]. Additional images[edit]. *. ... These portions of the ear are supplied by the cervical plexus and a small portion by the facial nerve. This explains why ... The fennec fox uses its distinctive oversized pinnae to radiate excess heat and to amplify the sound of small prey burrowing ...

https://en.wikipedia.org/wiki/Pinna_

For example: non-melanoma skin cancer, head and neck cancer, breast cancer, non-small cell lung cancer, cervical cancer, anal ... 2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV. The GEC ESTRO handbook of brachytherapy. Belgium ... Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ...

https://en.wikipedia.org/wiki/Radiation_therapy

"A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma ... Small-cell carcinoma is most often more rapidly and widely metastatic than non-small-cell lung carcinoma (and hence staged ... Compared to non-small cell carcinoma, small cell carcinoma has a shorter doubling time, higher growth fraction, and earlier ... Although combined small-cell lung carcinoma is currently staged and treated similarly to "pure" small-cell carcinoma of the ...

https://en.wikipedia.org/wiki/Small-cell_carcinoma

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC ... Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ... using a uniform scheme for non-small cell lung carcinoma, small-cell lung carcinoma and broncho-pulmonary carcinoid tumors.[30] ... Pie chart showing incidences of non-small cell lung cancers as compared to small cell carcinoma shown at right, with fractions ...

https://en.wikipedia.org/wiki/Non-small-cell_lung_carcinoma

Limited-stage small cell lung carcinoma (LS-SCLC) is a type of small cell lung cancer (SCLC) that is confined to an area which ... 33% patients with small cell lung cancer are diagnosed with limited-stage small cell lung carcinoma when it is first found. ... can also be associated with small cell lung cancer. Unlike extensive-stage small cell lung cancer, limited-stage small cell ... Unlike extensive-stage small cell lung cancer, limited-stage small cell lung cancer is potentially curable. In limited small ...

https://en.wikipedia.org/wiki/Limited-stage_small_cell_lung_carcinoma

... also called oat cell carcinoma, can create its own hormones, which alter body chemistry. ... Small cell carcinoma, also called oat cell carcinoma, can create its own hormones, which alter body chemistry. ...

https://medlineplus.gov/ency/imagepages/18016.htm

Non-small cell carcinomas are the most common lung cancers. ...

https://medlineplus.gov/ency/imagepages/18015.htm

... as extrapulmonary small cell carcinoma (EPSCC). Small cell carcinoma is a distinct clinical and pathologic entity that arises ... it is not uncommon for these cells to arise in nonpulmonary sites, ... from cells of the amine precursor uptake and decarboxylation (APUD) system. ... Small cell carcinomas (SCC) commonly arise in the respiratory tract; however, ...

https://emedicine.medscape.com/article/284288-overview

This article reviews the recent literature on extrapulmonary small cell carcinomas. Until now, only four cases have been ... Small cell carcinoma of the skin is included. This form of small cell carcinoma is often excluded from the larger review series ... Carcinoma, Merkel Cell* / drug therapy, mortality, pathology. Carcinoma, Small Cell* / mortality, pathology, therapy. Diagnosis ... This article reviews the recent literature on extrapulmonary small cell carcinomas. Until now, only four cases have been ...

http://www.biomedsearch.com/nih/Extrapulmonary-small-cell-carcinoma/15813162.html

... Daniel J. Oh,1 Ellen Dinerman,1 Andrew H. Matthews,1 Abraham W. ... She was later diagnosed with small cell carcinoma of the lung. Conclusions. In this case report, we describe a critically ill ... However, its presence in solid tumors such as small cell carcinoma of the lung has been reported rarely [1-5]. Even fewer cases ... Bronchoscopy revealed purulent secretions and biopsy of the mass demonstrated small cell carcinoma. The CT abdomen revealed a ...

https://www.hindawi.com/journals/cricc/2017/6148350/

Primary Small Cell Neuroendocrine Carcinoma of Vagina: A Rare Case Report. Jignasa N. Bhalodia,1 Dhiren V. Kapapura,2 and Malay ... Jignasa N. Bhalodia, Dhiren V. Kapapura, and Malay N. Parekh, "Primary Small Cell Neuroendocrine Carcinoma of Vagina: A Rare ...

https://www.hindawi.com/journals/pri/2011/306921/cta/

Non-Small Cell Lung CarcinomaA Study In Patients With Non-Small Cell Lung Cancer To Test If Erlotinib Plus SU011248 Is Better ... Non-Small Cell Lung CarcinomaTrial of Pemetrexed With or Without PF-3512676 in Advanced Non-Small Cell Lung Cancer NCT00321308 ... Non-Small Cell Lung CarcinomaEvaluation Of The Efficacy Of The Combination Of Axitinib With Pemetrexed And Cisplatin In The ... Non-Small Cell Lung CarcinomaPH 1 Evaluation Of Oral CI-1033 In Combination With Paclitaxel/ Carboplatin As 1st Line ...

https://www.pfizer.com/science/find-a-trial/nct00768755

Non-Small-Cell Lung CarcinomaA Study In Patients With Non-Small Cell Lung Cancer Testing If Erlotinib Plus SU011248 (Sunitinib ... Non-Small-Cell Lung CarcinomaAn Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell ... Non-Small-Cell Lung CarcinomaStudy Of SU011248 In Patients With Metastatic Non-Small Cell Lung Cancer NCT00092001 ... Non-Small-Cell Lung CarcinomaMEK Inhibitor PD-325901 To Treat Advanced Non-Small Cell Lung Cancer NCT00174369 ...

https://www.pfizer.com/science/find-a-trial/nct00265317

Diseases : Carcinoma: Non-Small-Cell Lung, Carcinoma: Small Cell Lung, Lung Cancer, Lung Cancer: Metastatic ... Ganoderma is cytotoxic to both drug-sensitive and drug-resistant small-cell lung carcinoma cells and can reverse resistance to ... Diseases : Carcinoma: Small Cell Lung, Colon Cancer, Lung Cancer, Nasopharyngeal Cancer. Pharmacological Actions : Anti- ... Diseases : Carcinoma: Small Cell Lung, Nicotine/Tobacco Toxicity Pharmacological Actions : Angiogenesis Inhibitors, Anti- ...

http://www.greenmedinfo.com/disease/carcinoma-small-cell-lung-0

... tells Yahoo Entertainment that tests have determined the former child star has stage IV small cell carcinoma cancer after his ... Dustin Diamond completes first round of chemo amid stage IV small cell carcinoma diagnosis. Suzy Byrne. ·Editor, Yahoo ... Dustin Diamond has stage 4 small cell carcinoma, according to his rep. He had been diagnosed with cancer earlier this month. ( ... tells Yahoo Entertainment that tests have determined the former child star has stage IV small cell carcinoma cancer after his ...

https://uk.news.yahoo.com/dustin-diamond-completes-first-round-chemo-stage-4-small-cell-carcinoma-diagnosis-191504765.html

... but Memorial Sloan Kettering experts have experience treating both large cell neuroendocrine carcinoma and small cell carcinoma ... Gastrointestinal small cell carcinoma and large cell carcinoma are usually diagnosed at an advanced stage, after they have ... The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. ... Because small cell and large cell neuroendocrine carcinomas of the gastrointestinal tract are usually found at an advanced ...

https://www.mskcc.org/cancer-care/types/gastrointestinal-neuroendocrine/large-cell-small-cell-gastrointestinal-neuroendocrine-carcinoma

Small cell carcinoma of the urinary bladder (SCCB) is an extremely rare but aggressive tumour constituting less than 0.7% of ... Primary small cell carcinoma of the urinary bladder. October 8, 2019 Small cell carcinoma of the urinary bladder (SCCB) is an ... Diagnosis of SCCB is based on the WHO criteria for small cell lung carcinoma. A 58-year-old man who had presented with ... It is often misdiagnosed as transitional cell carcinoma, owing to the similarities in presentation. ...

https://www.urotoday.com/recent-abstracts/urologic-oncology/bladder-cancer/115561-primary-small-cell-carcinoma-of-the-urinary-bladder.html

Diseases : Non-Small-Cell Lung Carcinoma. Pharmacological Actions : Antiproliferative , Apoptotic, Cell cycle arrest, Tumor ... Diseases : Cancers: Drug Resistant, Lung Cancer, Non-Small-Cell Lung Carcinoma. Pharmacological Actions : Apoptotic, Cell cycle ... Diseases : Lung Cancer, Non-Small-Cell Lung Carcinoma. Pharmacological Actions : Antineoplastic Agents, Apoptotic, Cell cycle ... Diseases : Lung Cancer, Non-Small-Cell Lung Carcinoma. Pharmacological Actions : Anti-metastatic, Antiproliferative , Cell ...

https://www.greenmedinfo.com/disease/non-small-cell-lung-carcinoma

Expression of neurophysin-related precursor in cell membranes of a small-cell lung carcinoma. L C Rosenbaum, E A Neuwelt, H H ... Expression of neurophysin-related precursor in cell membranes of a small-cell lung carcinoma ... Expression of neurophysin-related precursor in cell membranes of a small-cell lung carcinoma ... Expression of neurophysin-related precursor in cell membranes of a small-cell lung carcinoma ...

https://www.pnas.org/content/87/24/9928

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...

https://thorax.bmj.com/content/41/11/896.1

Thymic carcinoma. Small cell carcinoma. Reviewer: Hanni Gulwani, M.D. (see Reviewers page). Revised: 9 March 2013, last major ... Lymphoma: keratin-, CD45+ End of Mediastinum > Thymic carcinoma > Small cell carcinoma. This information is intended for ... Also called oat cell carcinoma, undifferentiated neuroendocrine carcinoma Sites. ... Clusters of small blue cells with minimal cytoplasm, hyperchromatic nuclei, no / minimal nucleoli, nuclear molding, frequent ...

http://www.pathologyoutlines.com/topic/mediastinumsmallcell.html

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...

https://www.drugbank.ca/indications/DBCOND0103105

Pathology obtained from transurethral resection of the prostate revealed pure small cell carcinoma of the prostate. ... An Unusual Etiology of Urinary Retention - Small Cell Prostate Carcinoma June 29, 2016 We report the case of a 63-year-old male ... Small cell carcinoma is an aggressive variant of prostate cancer that often presents late in the clinical course. We review the ... Pathology obtained from transurethral resection of the prostate revealed pure small cell carcinoma of the prostate. Metastatic ...

https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/89684-an-unusual-etiology-of-urinary-retention-small-cell-prostate-carcinoma.html

Small cell carcinoma information including symptoms, causes, diseases, symptoms, treatments, and other medical and health ... Small cell carcinoma. Description of Small cell carcinoma. Small cell carcinoma: highly malignant carcinoma composed of small ... Terms Similar to Small cell carcinoma:. *oat cell carcinoma Source - WordNet 2.1 Broader terms for Small cell carcinoma. * ... Small cell *Small *Small syndrome *Cell *Carcinoma *Anaplastic *Malignant *Bronchogenic *Ovoid *Cytoplasm Terms associated with ...

https://www.rightdiagnosis.com/medical/small_cell_carcinoma.htm

Adjuvant BEmiparin in Small Cell Lung Carcinoma (ABEL STUDY). The safety and scientific validity of this study is the ... Adjuvant therapy with bemiparin in patients with limited-stage small cell lung cancer: results from the ABEL study. Thromb Res ...

https://clinicaltrials.gov/ct2/show/results/NCT00324558?cond=%22Carcinoma%2C+Small+Cell%22

After Phil Gonzalez was diagnosed with squamous cell carcinoma in the left side of his jaw, he came to MD Anderson. But Phil ... After Phil Gonzalez was diagnosed with squamous cell carcinoma in the left side of his jaw, he came to MD Anderson. But Phil ... Phil had squamous cell carcinoma of the left mandible, a type of head and neck cancer. He quickly scheduled an appointment with ... During his squamous cell carcinoma treatment, his wife brought him his favorite food, a banana split, but he couldnt taste it ...

https://www.mdanderson.org/cancerwise/after-squamous-cell-carcinoma-appreciating-the-little-things.h00-158984289.html

... invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell ... lung carcinomas (NSCLC) and certain other human carcinomas. ... cultured cells from a non-small cell lung carcinoma, and (3) ... human lung carcinoma cells from pleural effusions or cultured cells from human non-small cell lung carcinoma, or cells from a ... Lung Carcinoma. Adeno 18/19. Squamous 8/10. Small Cell 2/6. Large Cell 2/2. Breast Carcinoma 13/16. Colon Carcinoma 9/9. ...

http://www.freepatentsonline.com/4906562.html

PubMed journal article Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrenc were found in PRIME ... Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence.. Int J Surg Pathol 2009; 17(1):46-50IJ ... Small Cell Carcinoma: Arising in Lynch Syndrome: a Previously Undocumented Occurrence. Int J Surg Pathol. 2009;17(1):46-50. ... Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence. Int J Surg Pathol. 2009;17(1):46-50. ...

https://www.unboundmedicine.com/medline/citation/18480399/Small_cell_carcinoma:_arising_in_Lynch_syndrome:_a_previously_undocumented_occurrence_

Small Cell Carcinoma of the Ovary, Hypercalcemic Type is a rare and aggressive cancer that typically strikes girls and young ... Small Cell Carcinoma of the Ovary, Hypercalcemic Type - Clinical Trials Fund. .BBFormSelectList{text-transform: capitalize;}. ... It is also the average age of diagnosis for small cell carcinoma of the ovaries hypercalcemic type (SCCOHT) - a highly ... Today, we ask you to join our fight against ovarian cancer by supporting TGens Small Cell Ovarian Cancer Clinical Trial. ...

https://www.tgen.org/giving/celebration-of-life/special-funds/sccoht-clinical-trials-fund/

... little is known about how to prevent it. Recently this type of lung cance ... Because little is known about the actual cause of bronchoalveolar carcinoma, ... Non-Small Cell Lung Cancer. The most common type of lung cancer, non-small cell lung cancer (NSCLC) affects tens of thousands ... Continue Learning about Non-Small Cell Lung Cancer. Treating Non-Small Cell Lung Cancer with Immunotherapy ...

https://www.sharecare.com/health/non-small-cell-lung-cancer/can-bronchoalveolar-carcinoma-be-prevented

Carcinoma, Non-Small-Cell Lung. Carcinoma, Bronchogenic. Bronchial Neoplasms. Lung Neoplasms. Respiratory Tract Neoplasms. ... Local Consolidative Radiotherapy for Oligoprogressive in Non-small Cell Lung Carcinoma. The safety and scientific validity of ... to all sites of oligoprogressive disease in patients with metastatic non-small cell lung carcinoma who have progressed through ... Non Small Cell Lung Cancer Oligoprogressive Radiation: Local consolidative radiation therapy Drug: Standard of care radiation ...

https://clinicaltrials.gov/show/NCT04485026

It can inhibit the growth and induce morphological changes of NSCLC cells in gene transfection studies. To explore the ... gene is a recently identified tumor suppressor gene for human non-small cell lung carcinoma (NSCLC). ... DLC-1 tumor supressor gene induces apoptosis in human non-small cell lung carcinoma cells following a unique process of cell ... Tumors; Cell-morphology; Carcinomas; Cell-growth; Microscopy; Genes; Tumorigens; Tumorigenesis; Gene-mutation; Liver-cells; ...

https://www.cdc.gov/niosh/nioshtic-2/20029957.html

Non-small-cell lung carcinoma ( NSCLC ) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). (wikipedia.org)
The most common types of NSCLC are squamous cell carcinoma , large cell carcinoma , and adenocarcinoma , but there are several other types that occur less frequently. (wikipedia.org)
[5] Non-squamous cell carcinoma almost occupy the half of NSCLC. (wikipedia.org)
LCLC's have typically comprised around 10% of all NSCLC in the past, although newer diagnostic techniques seem to be reducing the incidence of diagnosis of "classic" LCLC in favor of more poorly differentiated squamous cell carcinomas and adenocarcinomas. (wikipedia.org)
Nonsquamous-cell carcinoma almost occupies the half of NSCLC. (wikipedia.org)
AG-013736 (axitinib) in combination with cisplatin and pemetrexed will be evaluated as first-line treatment of patients with locally advanced, recurrent, or metastatic non-squamous, non small cell lung cancer (NSCLC). (pfizer.com)
Patients with mixed NSCLC with predominantly squamous cell carcinoma should be classified as squamous and thus do not qualify for this study. (pfizer.com)
NSCLC that cannot be classified as one of the eligible histologies (adenocarcinoma, large cell or bronchioalveolar). (pfizer.com)
The present invention is concerned with novel monoclonal antibodies which define a glycolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. (freepatentsonline.com)
The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. (freepatentsonline.com)
The most common type of lung cancer, non-small cell lung cancer (NSCLC) affects tens of thousands of people each year. (sharecare.com)
The deleted in liver cancer (DLC-1) gene is a recently identified tumor suppressor gene for human non-small cell lung carcinoma (NSCLC). (cdc.gov)
It can inhibit the growth and induce morphological changes of NSCLC cells in gene transfection studies. (cdc.gov)
A cDNA array analysis was carried out on 5-aza-dC-treated and untreated non small cell lung cancer (NSCLC) cell line NCI-H522. (cdc.gov)
Among them, downregulation of tyrosine protein kinase ABL2 (ABL2) gene and upregulation of hint/protein kinase C inhibitor 1 (Hint/PKCI-1), DVL1, TIMP-1, and TRP-1 genes were found in expanded observations in two or three of five 5-aza-dC-treated NSCLC cell lines. (cdc.gov)
Among these genes, we found that cDNA transfer of Hint/PKCI-1 resulted in a significant in vitro growth inhibition in two cell lines exhibiting 5-aza-dC-induced upregulation of Hint/PKCI-1 and significantly reduced in vivo tumorigenicity of one NSCLC cell line. (cdc.gov)
Non-small Cell Lung Carcinoma is also known as non-small cell lung carcinoma, nonsmall cell lung cancer, nsclc, non-small cell lung cancer (disorder), carcinoma, non-small-cell lung, carcinoma non-small cell lung, carcinoma of lung. (novusbio.com)
Recently, crizotinib, a small molecule inhibitor of ALK, was shown to selectively inhibit the growth of ALK-positive NSCLC ( 6 - 8 ), indicating that a subclass of NSCLC patients are likely to benefit clinically from an ALK inhibitor. (spandidos-publications.com)
However, since the incidence of ROS1 or RET fusions is less than that of ALK fusions in NSCLC, only a small number of NSCLC patients with ROS1 or RET fusions has thus far been identified. (spandidos-publications.com)
The purpose of this work was to assess the capacity of tumor-infiltrating leukocytes (TIL) from human non-small-cell lung carcinoma (NSCLC) specimens to synthesize type-1 and type-2 cytokines. (nih.gov)
The May edition of the Journal of Thoracic Oncology features a study aimed to clarify expression patterns of a novel cancer biomarker, CD24, in non-small cell lung carcinomas (NSCLC) and to correlate the findings to clinicopathologic variables, such as performance status, age, gender and prognostic significance. (scienceblog.com)
NSCLC (includes squamous, large cell or adenocarcinoma). (knowcancer.com)
Chromosome band 9p21 is deleted frequently in non-small cell lung carcinoma (NSCLC), and the p15 and p16 cyclin-dependent kinase-4 inhibitor genes map within this deletion region. (aacrjournals.org)
Recent studies demonstrated deletion of p15 and p16 in NSCLC metastases and cell lines, suggesting a role for these genes in NSCLC progression. (aacrjournals.org)
We studied both the antiproliferative and antitumor properties of a fucoidan extract (HF) obtained from the brown seaweed Ascophyllum nodosum on a cell line derived from a non-small-cell human bronchopulmonary carcinoma (NSCLC-N6), this type of carcinoma is particularly chemo-resistant. (nih.gov)
Recent data suggest that the tumour, node, metastasis classification traditionally reserved for the staging of nonsmall cell lung cancer (NSCLC) can also be applied for the staging of SCLC 3 . (ersjournals.com)
in small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). (ersjournals.com)
Retinoblastoma (RB) protein expression was examined in paraffin and frozen tissue sections of 36 primary non-small cell lung carcinomas (NSCLC) using immunohistochemistry with confirmation by direct Western blotting. (aacrjournals.org)
The modest response of patients with head and neck squamous cell carcinoma (HNSCC) and non-small cell lung carcinoma (NSCLC) to epithelial growth factor receptor tyrosine kinase inhibitors such as gefitinib and erlotinib indicates the need for the development of biomarkers to predict response. (aacrjournals.org)
We confirmed that increased protein expression of vimentin combined with the loss of E-cadherin, claudin 4, and claudin 7 by immunoblotting was associated with gefitinib resistance in both HNSCC and NSCLC cell lines. (aacrjournals.org)
Parathyroid hormone-related protein (PTHrP) is commonly expressed in non-small cell lung carcinomas (NSCLC). (aacrjournals.org)
Because roughly two thirds of non-small cell lung cancers (NSCLC) express PTHrP regardless of histology ( 20 ), the protein could be important in the pathophysiology of the disease beyond its role in causing hypercalcemia. (aacrjournals.org)
To identify the pattern of IRAK-1 protein expression in non-small cell lung carcinoma (NSCLC) and corresponding preneoplastic lesions. (pubmedcentralcanada.ca)
the two most common NSCLC histologic types are squamous cell carcinoma (SCC) and adenocarcinoma (ADCA) ( 2 ). (pubmedcentralcanada.ca)
Both NSCLC histologic types are believed to arise after a sequential progression of premalignant lesions, which include bronchial squamous metaplasias and dysplasias for squamous cell carcinoma, and peripheral atypical alveolar hyperplasias (AAH) for a subset of adenocarcinomas ( 3 ). (pubmedcentralcanada.ca)
Attending the seminar, Dr Basma M'Barek, Hy Vong Cancer Care Centre from FV Hospital, shared her experiences on the topic Optimizing When Using Osimertinib in Treating Non-Small-Cell Lung Carcinoma NSCLC & Sharing Treated Cases . (fvhospital.com)
our earlier studies had shown that reported ID1 is induced by nicotine or EGF stimulation of non-small cell lung cancer (NSCLC) cells and its down regulation abrogates cell proliferation, invasion and migration. (springer.com)
A microarray analysis was done on two different NSCLC cell lines (A549 and H1650) that were transfected with a siRNA to ID1 or a control, non-targeting siRNA. (springer.com)
STMN3 and GSPT1 were found to facilitate the proliferation, invasion and migration of NSCLC cells in response to nAChR activation. (springer.com)
Compared to non-small cell lung cancer (NSCLC), SCLC is generally more aggressive, with decreased doubling times and faster growth rates. (biomedcentral.com)
Aberrant signalling of receptor tyrosine kinases (RTKs), such as c-Met, the receptor for hepatocyte growth factor (HGF), has been implicated in the oncogenesis of various tumours including non-small cell lung carcinoma (NSCLC). (biologists.org)
This finding was confirmed in several NSCLC cell lines as well as in HeLa cells. (biologists.org)
However, the immunological profile of non-small cell lung carcinoma (NSCLC) treated with neoadjuvant chemotherapy (NCT) is not yet fully characterized, and it may be therapeutically important. (deepdyve.com)
The MAGE-A3 cancer/testis antigen is frequently expressed in non-small cell lung cancer (NSCLC) and vaccination with MAGE-A3 in patients with MAGE-A3-positive NSCLC has shown promising results. (biomedcentral.com)
However, little is known about the expression of other cancer/testis antigens in NSCLC. (biomedcentral.com)
Non-small cell lung cancer (NSCLC) accounts for more than 85% of new cases of lung cancer, which is the leading cause of cancer deaths worldwide [ 7 ], highlighting the need for novel therapeutic strategies for treatment of this disease. (biomedcentral.com)
Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. (ersjournals.com)
Until the arrival of pemetrexed, a relatively simple distinction between small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC) was sufficient to guide systemic treatment, and a meta-analysis of four different platinum doublets showed that none offered a significant advantage over the others in the treatment of advanced NSCLC [ 1 ]. (ersjournals.com)
As a result, the pathological diagnosis of lung cancer has become a multistep process, beginning with morphology and immunohistochemistry (IHC) to discriminate benign from malignant process, metastases from primary lung cancer and small cell lung carcinoma and NSCLC. (ersjournals.com)

citation needed] Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for surgery in this disease since the 1970s. (wikipedia.org)
In ES-SCLC, platinum-based combination chemotherapy is the standard of care, with radiotherapy added only to palliate symptoms such as dyspnea, pain from liver or bone metastases, or for treatment of brain metastases, which, in small-cell lung carcinoma, typically have a rapid, if temporary, response to whole brain radiotherapy. (wikipedia.org)
citation needed] In August 2018, the FDA approved nivolumab to treat patients with metastatic small cell lung cancer (SCLC) who failed to respond to platinum-based chemotherapy and at least one other line of treatment. (wikipedia.org)
In these cases, the tumors are classified as combined small cell lung carcinoma (c-SCLC), [7] and are (usually) treated like "pure" SCLC. (wikipedia.org)
LCLC is differentiated from small cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. (wikipedia.org)
The diagnostic criteria for EPSCC require that the tumor demonstrate histolgic features of small cell carcinoma in the absence of small cell lung cancer (SCLC). (medscape.com)
Multidrug resistance is a major problem in small-cell lung cancer (SCLC). (nih.gov)
We tested the effects of Ganoderma on drug-sensitive (H69) and multi-drug resistant (VPA) human SCLC cells. (nih.gov)
When compared untreated controls or SCLC cells treated with extracts of non-cytotoxic Ganoderma species, cells treated with extracts of cytotoxic Ganoderma species responded with an induction of apoptosis similar to cells treated with the chemotherapeutic drugs etoposide and doxorubicin. (nih.gov)
Pre-incubation of drug-resistant SCLC cells with cytotoxic Ganoderma reduced the IC(50) for etoposide (3.4-0.21 microM) and doxorubicin (0.19-0.04 microM). (nih.gov)
These results show that extracts of several species of Ganoderma are cytotoxic to both drug-sensitive and drug-resistant SCLC cells, are pro-apoptotic, induce gene expression patterns that are similar to SCLC cells treated with chemotherapeutic drugs, and can reverse resistance to chemotherapeutic drugs. (nih.gov)
Small cell carcinoma of the lung (SCLC) together with the large cell neuroendocrine carcinoma (LCNEC), typical carcinoid (TC), and atypical carcinoid (AC) make a group of morphologically identifiable neuroendocrine tumors. (srce.hr)
The differential diagnosis of SCLC includes, first of all, other neuroendocrine tumors, and primary or metastatic non-small cell carcinomas. (srce.hr)
This is a Phase 1a/1b study of SC-002 in patients with relapsed small cell lung cancer (SCLC) or large cell neuroendocrine carcinoma (LCNEC). (clinicaltrials.gov)
Part 1A is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with cytologically confirmed, limited or extensive SCLC or LCNEC that have relapsed or refractory limited or extensive disease following no more than 2 prior chemotherapy regimens. (clinicaltrials.gov)
In lung cancer, somatic mutations of epidermal growth factor receptor (EGFR) are concentrated in exons 18-21, especially in adenocarcinoma (Ad), but these mutations have rarely been reported in small cell lung carcinoma (SCLC). (nih.gov)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
In contrast, little progress has been made in the treatment of extensive-stage SCLC (ES-SCLC), apart from the recently documented survival gain by the addition of prophylactic cranial irradiation. (ersjournals.com)
Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
Recently, prophylactic cranial irradiation (PCI) has been shown to improve outcome in patients with ES-SCLC 4 , but only small advances have been made otherwise. (ersjournals.com)
This is the first case report of nab-PAC+CBDCA therapy in small cell lung cancer (SCLC). (go.jp)
Our patient was a 72-year-old man with stage IV SCLC combined with squamous cell carcinoma and interstitial lung disease (ILD). (go.jp)
Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. (aacrjournals.org)
Consistent with these findings, murine non-neuroendocrine SCLC tumors are rejected in a syngeneic model, with clonal expansion of immunodominant effector CD8 T cells. (aacrjournals.org)
Therapeutically, EZH2 inhibition followed by STING agonism enhances T cell recognition and rejection of SCLC in mice. (aacrjournals.org)
No novel chemotherapeutic combinations have demonstrated superior efficacy to etoposide/cisplatin (EP), a standard treatment regimen for extensive-stage small cell lung carcinoma (ES-SCLC) over the past decade. (biomedcentral.com)
In 2015, large cell neuroendocrine carcinoma (LCNEC) was removed from the large cell carcinoma group and classified with small cell lung carcinoma (SCLC) constituting two members of the high-grade neuroendocrine tumors (NETs) of the lung. (jcancer.org)

Primary malignant tumors of the hypopharynx are predominantly squamous cell carcinomas (SqCCs), as primary small-cell carcinoma (SmCC) of the hypopharynx is rare. (spandidos-publications.com)
Squamous cell carcinomas (8.1%) and large cell carcinomas (12.1%) showed high PD-L1 expression more commonly than adenocarcinomas (5.1%) but this was not statistically significant (p=0.072). (garvan.org.au)
Squamous cell carcinomas (SCC) are more frequent among smoking men while females develop adenocarcinomas (ADCA). (diva-portal.org)
When Point-EXACCT was used, K- ras codon 12 mutations were detected in 8 of 52 patients with squamous cell carcinomas, 10 of 29 patients with adenocarcinomas, and 3 of 8 patients with large cell carcinomas. (aaccjnls.org)
The finding of K- ras mutations in squamous cell carcinomas is explained by the high sensitivity of the method. (aaccjnls.org)
Selected agents ( e.g. pemetrexed and nintedanib) show superior efficacy in adenocarcinomas and large cell carcinomas when compared to squamous cell carcinomas (SqCC) [ 2 - 5 ]. (ersjournals.com)

A few neuroendocrine tumors found in the gastrointestinal tract are made of fast-growing, poorly differentiated cancer cells, and respond to different treatments than those used for carcinoid tumors. (mskcc.org)
Other leukocytes such as macrophages (CD14), B lymphocytes (CD20), and natural killer (NK) cells (CD56) were also found to infiltrate the tumors, but in significantly lower numbers. (nih.gov)
Two additional RB positive primary tumors have major foci in which all tumor cells showed no RB protein staining. (aacrjournals.org)
As extra-pulmonary small cell carcinoma (EPSCC) is a rare entity of tumors, the available treatment recommendations are mainly based on retrospective analyses and deduction from treatment of small cell lung cancer. (springermedizin.de)
Keywords: Tumor compartments, Epithelial compartment, Stromal compartment, Adenocarcinoma, Squamous cell carcinoma, Survival, T cells Background suggesting that strategies to control and modify the im- Tumors grow by using a complex composite system that mune cell population are important approaches to can- includes epithelial and stromal cell activation, vessel pro- cer therapy. (deepdyve.com)
Wang J, Ye L, Cai H, Jin M. Comparative study of large cell neuroendocrine carcinoma and small cell lung carcinoma in high-grade neuroendocrine tumors of the lung: a large population-based study. (jcancer.org)

Small-cell carcinoma is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. (wikipedia.org)
This is most often the case when a pathologist examines a small amount of malignant cells or tissue in a cytology or biopsy specimen. (wikipedia.org)
Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung. (wikipedia.org)
Research of Non-small Cell Lung Carcinoma has been linked to Malignant Neoplasm Of Lung, Malignant Neoplasms, Lung Neoplasms, Neoplasms, Carcinoma. (novusbio.com)
If you have been diagnosed with bronchoalveolar carcinoma, it is important to begin treatment immediately to prevent the malignant tumor from metastasizing (spreading). (sharecare.com)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. (thefreedictionary.com)
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
Hürthle cell carcinoma a malignant Hürthle cell tumor . (thefreedictionary.com)
Primary small-cell carcinoma of the cervix (SCCC) is recognised as a rare and aggressive malignant tumour with poor prognosis. (ovid.com)
In normal situations, T lymphocytes recognize ma- pressive, it is now accepted that certain chemotherapy lignant cells as abnormal and activate cytotoxic T lym- agents, such as paclitaxel, cisplatin, gemcitabine, and phocytes through helper T cells at the site, which carboplatin, can regulate and modulate antitumor im- infiltrate and kill the malignant cells. (deepdyve.com)

DLC-1 tumor supressor gene induces apoptosis in human non-small cell lung carcinoma cells following a unique process of cell morphological changes and protein nuclear translocation. (cdc.gov)
Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2 '-deoxycytidine. (cdc.gov)
In the present study, we investigated the effect of trifluoperazine on (a) survival of bleomycin-treated human non-small cell lung carcinoma U1810 cells, (b) induction and repair of bleomycin-induced DNA strand breaks, and (c) nonhomologous end-joining (NHEJ), the major DNA double-strand break (DSB) repair pathway in mammalian cells. (diva-portal.org)

Atezolizumab was associated with a significant improvement in overall survival (HR for death = 0.70) Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. (wikipedia.org)
Median survival in the group of patients with histologically confirmed small cell cancer was 238 days, for women 250 days, and for men 237 days. (srce.hr)
10- and 20-year survival is 63% and 44% respectively (papillary thyroid carcinoma has 95% 10-year survival). (thefreedictionary.com)
in contrast, papillary thyroid carcinoma has 95% 5- and 10-yr survival. (thefreedictionary.com)
To develop reliable nomograms to estimate individualized overall survival (OS) and cancer specific survival (CSS) for patients with primary small cell carcinoma of the bladder (SCCB) and compare the predictive value with the AJCC stages. (jcancer.org)
It has been hypothesized that chronic inflammation is a major consequence of certain environmental factors eventually leading to increased proliferation, survival, and migration of epithelial cells, as well as angiogenesis in the adjacent stroma, thereby promoting epithelial tumor development ( 4 - 6 ). (pubmedcentralcanada.ca)
INTRODUCTION: Little is known about small cell carcinoma of the upper urinary tract (UUT-SCC), the aim of this study is to identify the risk factors in relation to survival of patients with UUT-SCC. (minervamedica.it)

[13] LCLC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer. (wikipedia.org)
Histologic criteria for diagnosis of extrapulmonary small cell carcinoma are same as those for pulmonary small cell carcinoma: the presence of uniform small cells with sparse cytoplasm, dense nuclei, and inconspicuous nucleoli. (medscape.com)
Cytologic specimens for diagnosis or for cell type classification must have been obtained from bronchial brushings or washings or from needle aspiration of a defined lesion. (pfizer.com)
Sputum cytology alone will not be acceptable for diagnosis or for cell type classification. (pfizer.com)
A rep for the Saved By the Bell alum, 44, tells Yahoo Entertainment that tests have determined the former child star has stage IV small cell carcinoma cancer after his initial cancer diagnosis earlier this month. (yahoo.com)
By the time a person gets a diagnosis, small cell lung cancer has typically spread (metastasized) outside of the lungs. (yahoo.com)
The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. (mskcc.org)
Diagnosis of SCCB is based on the WHO criteria for small cell lung carcinoma. (urotoday.com)
It is also the average age of diagnosis for small cell carcinoma of the ovaries hypercalcemic type (SCCOHT) - a highly aggressive tumor that kills more than 65 percent of patients within two years of initial diagnosis. (tgen.org)
In the remaining 77 patients, histological verification of cytological diagnosis was not made and the patients were treated based on cytological diagnosis of small cell carcinoma. (srce.hr)
In 76% of cases (38/50) cytological diagnosis of small cell lung carcinoma was also confirmed histologically. (srce.hr)
A diagnosis of extensive stage small-cell lung cancer was made. (thefreelibrary.com)
Aims To test the incidence of the expression of the immunohistochemical markers that aid diagnosis of gastrointestinal tract small cell carcinoma (GI-SmCC) and to evaluate the incidence of mixed endocrine-exocrine carcinomas in GI-SmCC. (bmj.com)
The patient had axillary and hepatic metastases at the time of diagnosis, and the clinical course suggests that this tumor behaves in an aggressive fashion, analogous to other small cell neuroendocrine carcinomas. (semanticscholar.org)
A diagnosis of poorly differentiated (high-grade) non-small cell neuroendocrine carcinoma was made after a histological analysis and immunostaining. (cureus.com)

Extensive stage small cell lung cancer is classified as a rare disorder. (wikipedia.org)
Historically, adenocarcinoma was more often seen peripherally in the lungs than small cell lung cancer and squamous cell lung cancer, both of which tended to be more often centrally located. (wikipedia.org)
Like pulmonary small cell carcinoma ( lung cancer ), small cell carcinomas arising from extrapulmonary sites may be associated with paraneoplastic syndromes , notably syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hypercalcemia . (medscape.com)
Extrapulmonary small cell carcinoma may have a similar prognosis to that of small cell lung cancer. (medscape.com)
Small cell or carcinoid lung cancer patients are also ineligible. (pfizer.com)
Siberian ginseng extracts had atiproliferative activity on various cancer and normal cell lines. (greenmedinfo.com)
According to the Cleveland Clinic , "Small cell lung cancer is fast-growing lung cancer that develops in the tissues of the lungs. (yahoo.com)
It is also the "least common type of lung cancer" and spreads faster than non-small cell lung cancer. (yahoo.com)
Spontaneous regression of metastatic squamous cell lung cancer. (greenmedinfo.com)
Citrus reticulata peel oil inhibits non-small cell lung cancer cell proliferation. (greenmedinfo.com)
Shikonin could be a novel therapeutic strategy against non-small cell lung cancer. (greenmedinfo.com)
Small cell carcinoma is an aggressive variant of prostate cancer that often presents late in the clinical course. (urotoday.com)
Phil had squamous cell carcinoma of the left mandible, a type of head and neck cancer. (mdanderson.org)
Today, we ask you to join our fight against ovarian cancer by supporting TGen's Small Cell Ovarian Cancer Clinical Trial. (tgen.org)
Immunotherapies are a category of cancer drugs that work by helping the body's immune system identify and destroy cancer cells. (sharecare.com)
What are the different types of non-small cell lung cancer? (sharecare.com)
How can I prepare for an appointment for non-small cell lung cancer? (sharecare.com)
A new approach in identifying alterations of genes that might be relevant to the process of tumor development was used in this study by examining the gene expression profile in human lung cancer cells exposed to 5-aza-2'-deoxycytidine (5-aza-dC). (cdc.gov)
Although the surgical margin was narrow, it was negative for cancer cells. (spandidos-publications.com)
What do I need to know about caring for someone with non-small cell cancer? (sharecare.com)
Small cell lung cancer, another neuroendocrine tumor, is associated with paraneoplastic syndromes (PNS) in up to 20% of cases, notably the syndrome of inappropriate antidiuretic hormone (SIADH) and Lambert-Eaton myasthenic syndrome. (aad.org)
It is more commonly associated with non-small-cell lung cancer, but the temporal association with Bowen's disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer. (thefreelibrary.com)
Zurück zum Zitat Brennan SM, Gregory DL, Stillie A et al (2010) Should extrapulmonary small cell cancer be managed like small cell lung cancer? (springermedizin.de)
Listen as Dr. London Smith (.com) and his producer Cameron discuss Small Cell Lung Cancer with special guest Dr. Benjamin Evans. (stitcher.com)
It has recently been shown that nanoparticle albumin-bound paclitaxel (nab-PAC)+carboplatin (CBDCA) provides a favorable overall response rate in non-small cell lung cancer. (go.jp)
This case indicates that metastasis induced acute pancreatitis can be a manifestation of lung cancer, especially in small cell carcinoma. (eurekamag.com)
The frequencies of micronuclei were measured in lymphocytes of 6 patients with small cell lung cancer treated with a combination of cisplatin and etoposide and 7 patients with ovarian carcinoma treated with a combination of taxol and cisplatin. (ovid.com)
get your pathology reviewed to see if it is a small cell lung cancer or neuroendocrine carcinoid tumor from your small bowel. (justanswer.com)
A form of cancer , carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. (thefreedictionary.com)
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells , rarely metastatic but locally invasive and aggressive. (thefreedictionary.com)
Expression of the protein could have implications for progression of the disease because it regulates cancer cell growth, apoptosis, and angiogenesis. (aacrjournals.org)
It is less widely appreciated that PTHrP also exerts effects direct effects on cancer cells that could be important in the pathology of malignancy. (aacrjournals.org)
Direct actions of PTHrP on cancer cells are frequently related to cell growth or life cycle. (aacrjournals.org)
For example, the protein alters the rate of proliferation in many cancer cell types ( 1 - 4 ) and can have regulatory effects on the propensity to undergo apoptosis ( 5 - 7 ). (aacrjournals.org)
PTHrP also modulates integrin ( 8 - 11 ) and metalloproteinase expression ( 12 ) in various cancer cells and inhibits angiogenesis ( 13 ). (aacrjournals.org)
Background: The ultimate goal of the study was to find a role of curcumin in targeting lung cancer stem cells by reducing their self-renewal efficiency causing DNA damage. (eurekaselect.com)
Materials and Methods: Circulating lung cancer stem cells were isolated by sphere formation assay and further analysed by flow-cytometry and qRT-PCR for the presence of stem cell and stem cell transcription markers. (eurekaselect.com)
Results and Conclusion: Our results demonstrated that curcumin significantly affect the self-renewal ability of circulating lung cancer stem cells. (eurekaselect.com)
Thus, we can conclude that curcumin can be used to target lung cancer stem cells which is responsible for the disease progression and metastasis by causing DNA damage or inhibiting their DNA repair mechanisms. (eurekaselect.com)
Sheefa Mirza, Aakanksha Vasaiya, Hemangini Vora, Nayan Jain and Rakesh Rawal*, "Curcumin Targets Circulating Cancer Stem Cells by Inhibiting Self-Renewal Efficacy in Non-Small Cell Lung Carcinoma", Anti-Cancer Agents in Medicinal Chemistry (2017) 17: 859. (eurekaselect.com)
In Vietnam, lung cancer has one of the highest death rates, with non-small-cell lung carcinoma accounting for 85% of patients being treated. (fvhospital.com)
Background and Purpose: Small cell carcinoma of the esophagus (SCEC) is a rare subtype of esophageal cancer for which optimal treatment is unknown. (eur.nl)
Sattler and Salgia, 2007 ) so that a detailed understanding of processes underlying c-Met-dependent cancer cell migration is important for providing opportunities for the development of new treatments for these diseases. (biologists.org)
We propose that TFP might be capable of inhibiting one or more elements of the DNA DSB repair machinery, thereby increasing the cytotoxicity of bleomycin in lung cancer cells. (diva-portal.org)
A group of lung cancers that are named for the kinds of cells found in the cancer and how the cells look under a microscope. (semanticscholar.org)
Non-small cell lung carcinoma is a leading cause of cancer mortality worldwide. (diva-portal.org)
Wistuba, Ignacio 2018-06-06 00:00:00 Background: The clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor types, including lung cancer. (deepdyve.com)
Conclusions: NCT-NSCLCs exhibited higher levels of PD-L1 expression and T-cell subset regulationthannon-NCT-NSCLCs, suggesting that NCT activates specific immune response mechanisms in lung cancer. (deepdyve.com)
Although neoadjuvant chemotherapy (NCT) liferation, and inflammatory and immune cell activation for cancer has historically been considered immunosup- [1]. (deepdyve.com)
A study presented by Kis et al at the World Congress on Advanced Treatments and Technologies in Skin Cancer (Skin Cancer 2019) ( Poster Board 6 ) aimed to evaluate the effectiveness of treatment with electrochemotherapy for locally advanced primary and recurrent eyelid-periocular basal cell carcinomas. (ascopost.com)
Historically, there has been little awareness of the rare but lethal small cell carcinoma (SCC) in association with prostate cancer. (canjurol.com)

Spike electrogenesis, local depolarizing and hyperpolarizing responses, spontaneous rhythmic firing, and alternating resting potentials were measured in cells from a continuously cultured small cell carcinoma of the lung. (sciencemag.org)

Can bronchoalveolar carcinoma be prevented? (sharecare.com)
Because little is known about the actual cause of bronchoalveolar carcinoma, little is known about how to prevent it. (sharecare.com)
How do I manage bronchoalveolar carcinoma on a daily basis? (sharecare.com)
Because bronchoalveolar carcinoma cells are known to be spread out throughout the lungs, it is crucial that you find and remove cancerous cells as soon as possible. (sharecare.com)
Ask your doctor how to stay healthy while being treated for bronchoalveolar carcinoma. (sharecare.com)
bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)

An abdominal CT showed a well-defined lesion in the superior right hepatic lobe consistent with a hepatic cyst and a mildly enlarged and heterogeneous left hepatic lobe concerning for possible hepatocellular carcinoma. (hindawi.com)
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles , consisting of two layers of cells surrounding a minute lumen. (thefreedictionary.com)
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. (thefreedictionary.com)

TTF-1 positive small cell cancers: Don't think they're always primary pulmonary! (medscape.com)
Primary small cell carcinoma of the urinary bladder. (urotoday.com)
A case report of primary small cell carcinoma of the breast and review of the literature. (biomedsearch.com)
Primary small cell carcinoma (SCC) of the breast, an exceedingly rare and aggressive tumor, is often characterized by rapid progression and poor prognosis. (biomedsearch.com)
Primary small cell carcinoma (SCC) of the breast is a subtype of neuroendocrine carcinoma. (biomedsearch.com)
Two cases of primary small cell carcinoma of the breast showing non-mass-like pattern on diagnostic imaging and histopathology. (semanticscholar.org)
An extremely rare case of primary small cell carcinoma of the distal third of the esophagus arising from dysplastic Barrett's esophagus is herein presented. (springer.com)
Histopathology revealed a primary small cell carcinoma of the distal third of the esophagus arising from dysplastic Barrett's esophagus. (springer.com)

Pie chart showing incidences of non-small cell lung cancers as compared to small cell carcinoma shown at right, with fractions of smokers versus non-smokers shown for each type. (wikipedia.org)
Non-small cell carcinomas are the most common lung cancers. (medlineplus.gov)
Approximately 1000 cases of extrapulmonary small cell carcinoma are reported annually in the United States, with an overall incidence of 0.1-0.4% of all cancers and 2.5-5% of all small cell carcinomas. (medscape.com)
Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese. (greenmedinfo.com)
lung cancers are frequently oat cell carcinomas. (rightdiagnosis.com)
A neuroendocrine tumour that comprises ±5% of thyroid cancers, arising in the C (parafollicular) cells of the ultimobranchial cleft-i.e., neural crest origin. (thefreedictionary.com)

basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements. (thefreedictionary.com)
Increasing evidence is emerging about the effectiveness of electrochemotherapy in the treatment of basal cell carcinomas in the head and neck region. (ascopost.com)
A total of 13 patients with basal cell carcinoma involving the eyelid-periocular region were treated with electrochemotherapy. (ascopost.com)
The researchers concluded, "Electrochemotherapy can be used effectively in the treatment of locally advanced or recurrent basal cell carcinomas in the eyelid-periocular region. (ascopost.com)
There is evidence that the development of poorly-differentiated neuroendocrine cells (similar to those found in oat cell carcinomas of the lung) can be seen in the progression of an initially pure adenocarcinoma, possibly due to the totipotential nature of the basal or reserve cells normally present in the prostatic acini. (canjurol.com)

[1] [2] As a class, NSCLCs are relatively insensitive to chemotherapy , compared to small cell carcinoma. (wikipedia.org)
Because small cell and large cell neuroendocrine carcinomas of the gastrointestinal tract are usually found at an advanced stage, treatment often begins with a combination of platinum-based chemotherapy drugs. (mskcc.org)
Thirteen months earlier, he developed small cell carcinoma of the lung and received 6 cycles of chemotherapy. (eurekamag.com)
Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung. (deepdyve.com)
Chemotherapy has a potential to trigger nant cells have developed sophisticated mechanisms and immune activation by inducing immunogenic cell death pathways through which they regulate negative and posi- and subsequent tumor-associated neoantigen release, tive signals, blocking cytotoxic T cell activation and which in turn activates antigen-presenting cells (APCs) regulatory T cells and thus promoting tumor growth and such as tumor-associated macrophages (TAMs) and eventual tumor metastasis [2]. (deepdyve.com)

Very few cases of small cell esophageal carcinoma arising in Barrett's esophagus have been reported in the literature. (springer.com)
Although small cell esophageal carcinoma is rare and its association with dysplastic Barrett's esophagus is extremely infrequent, the high carcinogenic risk of Barrett's epithelium should be kept in mind. (springer.com)
High-grade neuroendocrine carcinoma (NEC) of the esophagus is an extremely aggressive and rare disease, which is still not well understood. (cureus.com)
Our review of the literature revealed that further research is needed, focusing on neuroendocrine carcinomas of the esophagus and how this entity differs from some of the more well-known neuroendocrine neoplasms in terms of management. (cureus.com)
Neuroendocrine carcinoma of the esophagus is classified within the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) based on the 2010 World Health Organization (WHO) classification system. (cureus.com)
Thirteen patients with small cell carcinoma of the esophagus were treated at the Massachusetts General Hospital between 1978 and 1993. (elsevier.com)
Huncharek, M & Muscat, J 1995, ' Small cell carcinoma of the esophagus: The Massachusetts General Hospital experience, 1978 to 1993 ', CHEST , vol. 107, no. 1, pp. 179-181. (elsevier.com)

Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung. (nih.gov)

MATERIAL AND METHODS: Material from 29 cases of lung carcinoma (small cell, squamous cell, and adenocarcinomas) was examined immunohistochemically for Ki-67 and p53 expression in virtually constructed cylinders of different diameters. (diva-portal.org)
K- ras point mutations are found in approximately 15-56% of the adenocarcinomas and to a lesser extent in other types of non-small cell lung carcinomas (NSCLCs) ( 3 )( 5 )( 7 )( 8 )( 9 )( 10 )( 11 )( 12 )( 13 )( 14 ). (aaccjnls.org)

In 8% of cases (4/50) adenocarcinoma was histologically confirmed, in 10% (5/50) of the cases the squamous carcinoma was confirmed, and there was one case of urothelial carcinoma, one case of sarcoma and one undifferentiated carcinoma. (srce.hr)

A small cell bronchogenic carcinoma associated with tumoral hypophosphataemia and inappropriate antidiuresis. (bmj.com)
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. (thefreedictionary.com)
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation. (thefreedictionary.com)

This is a randomized phase II study designed to evaluate the effect of local consolidative radiation therapy (LCT) to all sites of oligoprogressive disease in patients with metastatic non-small cell lung carcinoma who have progressed through first line systemic therapy containing an immune checkpoint inhibitor (ICI). (clinicaltrials.gov)

The antibodies bind to normal human cells to a much lesser degree than to tumor cells. (freepatentsonline.com)
Altogether, our studies show that tumor cells use EVs as vehicles to carry over long distances and deliver to immune cells a metabolic checkpoint molecule - ARG1, mitigating anti-tumor immune responses. (izon.com)
In general in tumor tissue, a variable number of nonmalignant cells, such as stromal and inflammatory cells, are mixed with tumor cells. (aaccjnls.org)
Because K- ras mutations can be present in only a subpopulation of the tumor cells ( 12 ), a highly sensitive assay is required for the detection of these mutations. (aaccjnls.org)

however, it is not uncommon for these cells to arise in nonpulmonary sites, as extrapulmonary small cell carcinoma (EPSCC). (medscape.com)
[ 2 ] Since extrapulmonary small cell carcinoma has been reported in multiple sites, all cases are thought to have an identical cell of origin that derives from those originating in neural crest and then migrates to different epithelial sites within the body. (medscape.com)
Extrapulmonary small cell carcinoma has been reported to arise in almost all body sites except the central nervous system. (medscape.com)
[ 6 ] Global incidence of extrapulmonary small cell carcinoma is unknown. (medscape.com)
This article reviews the recent literature on extrapulmonary small cell carcinomas. (biomedsearch.com)

2. renal cell carcinoma . (thefreedictionary.com)
Clark PE, Schover LR, Uzzo RG, Hafez KS, Rybicki LA, Novick AC (2001) Quality of life and psychological adaptation after surgical treatment for localized renal cell carcinoma: impact of the amount of remaining renal tissue. (springer.com)

It is often misdiagnosed as transitional cell carcinoma, owing to the similarities in presentation. (urotoday.com)
Background: Small cell carcinoma of the bladder (SCCB) is a rare, poorly differentiated neuroendocrine epithelial tumour linked with a more assertive behaviour and poorer outcome than bladder transitional cell carcinoma (TCC). (alliedacademies.org)

In 1993, a skin biopsy of a lesion on his right elbow was positive for squamous cell carcinoma in situ. (thefreelibrary.com)

I been reading about poorly differated nueroendrocrine small cell carcinoma. (justanswer.com)
My report said small cell carcinoma poorly differated nueroendrocrine. (justanswer.com)
it says poorly differentiated nueroendrocrine small cell carcinoma. (justanswer.com)
Small-cell carcinoma is a variant of poorly differentiated neuroendocrine carcinoma. (ovid.com)
Small cell carcinoma of the bladder (SCCB) is a rare, poorly differentiated and aggressive neuroendocrine malignancy [ 1 ]. (jcancer.org)

Gastrointestinal small cell carcinoma and large cell carcinoma are usually diagnosed at an advanced stage, after they have spread to the lymph nodes or other organs. (mskcc.org)
Gastrointestinal tract small cell carcinoma is an infrequent and aggressive neoplasm that represents 0.1-1% of gastrointestinal malignancies. (springer.com)
Gastrointestinal tract small cell carcinoma is an infrequent and aggressive malignancy. (springer.com)
The tumour contains dense core granules similar to the argentaffin cell granules of the gastrointestinal tract and actively secretes hormones and hormone like products. (gpnotebook.com)

Small cell carcinoma of the urinary bladder (SCCB) is an extremely rare but aggressive tumour constituting less than 0.7% of all urinary bladder tumours. (urotoday.com)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a very rare and lethal tumor, mostly affecting young women, with aggressive clinical course. (thefreelibrary.com)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is exceedingly rare tumor with very aggressive behavior and strikingly poor prognosis. (thefreelibrary.com)
This is a highly aggressive, undifferentiated carcinoma which grows rapidly and metastasizes early. (gpnotebook.com)

adenocarcinoma of the lung , large cell carcinoma , small cell carcinoma , and squamous cell carcinoma . (thefreedictionary.com)

Ursolic Acid and oleanolic acid reduced the proliferation of A549 cells in nude mice. (greenmedinfo.com)
In a small interfering RNA (siRNA)-based high-throughput wound healing screen performed in A549 lung carcinoma cells, we identified ERK2 but not ERK1 as a strong mediator of HGF-induced motility. (biologists.org)

See Anaplastic carcinoma of thyroid, Follicular tumor of thyroid, Papillary carcinoma of thyroid, Thyroid lymphoma. (thefreedictionary.com)

Pathology obtained from transurethral resection of the prostate revealed pure small cell carcinoma of the prostate. (urotoday.com)

On August 31st2019, Ho Chi Minh City Oncology Hospital cooperated with AstraZeneca, a multinational pharmaceutical and biopharmaceutical company, to hold a Scientific Seminar About Diagnosing and Treating Non-Small-Cell Lung Carcinoma Having EGFR Mutation for doctors to discuss and share their experiences in treating the condition. (fvhospital.com)

On average, the frequencies of micronuclei increased during the first half of therapy and declined thereafter, reaching, in some patients with ovarian carcinoma, values below the pre-treatment level. (ovid.com)

A monoclonal antibody (mAb L6) to a small-cell lung carcinoma surface antigen recognizes a common epitope of vasopressin-neurophysin and oxytocin-neurophysin in hypothalamic nuclei. (pnas.org)
Immunohistochemical detection was performed for cytokeratin, epithelial membrane antigen, neuron-specific enolase (NSE), synaptophysin (Syn), chromogranin A (CgA), neuronal cell adhesion molecules (CD56), thyroid transcriptional factor-1 and S100 protein (S100). (ovid.com)
Transient EZH2 inhibition expands these non-neuroendocrine cells, which display intrinsic innate immune signaling and basally restored antigen presentation. (aacrjournals.org)
In mice, ARG1-containing EVs are transported to draining lymph nodes, taken up by dendritic cells and inhibit antigen-specific T-cell proliferation. (izon.com)

Biopsy A small sample of the tumor may be obtained for examination under a microscope using either a thin needle (fine-needle aspiration biopsy) or a wider needle (core biopsy). (mskcc.org)
Bronchoscopy revealed a right middle-lobe tumor, and the biopsy was positive for small-cell lung carcinoma. (thefreelibrary.com)
Biopsy showed small cell esophageal carcinoma. (springer.com)
Biopsy was taken and its evaluation revealed tumor to be small cell carcinoma. (alliedacademies.org)
Small samples (biopsy and cytology) require "tissue" management, which is best achieved by the interaction of all physicians involved. (ersjournals.com)

NECs are further classified into small cell, which is more common, and large cell [2] . (cureus.com)

cells of the tumour have endocrine like characteristics and may secrete one or more of a wide range of hormones , especially regulatory peptides like bombesin . (biology-online.org)
In line with the isoform-specific requirement of ERK2 for HGF-mediated migration in lung tumour cell models, ERK2 but not ERK1 is shown to be responsible for paxillin serine 126 phosphorylation and its increased turnover at focal adhesions. (biologists.org)
oat cell tumour - characterised by uniform small - to - medium sized, closely packed cells arranged in strands, clusters, or singly, with dark-staining nuclei and a high nuclear:cytoplasmic ratio. (gpnotebook.com)
Liquid biopsies ( i.e. analysis of cell-free tumour DNA from blood plasma) have become another important option in such a situation, but are not within the scope of this review. (ersjournals.com)

A number of other malignancies, including those derived from the ovary, stomach, small bowel, and urothelium, have also been linked to this syndrome. (unboundmedicine.com)

These pathways complement our catalog of research reagents for the study of Non-small Cell Lung Carcinoma including antibodies and ELISA kits against EGFR, TP53, VEGFA, MID1, CDKN2A. (novusbio.com)
No somatic mutations were detected in the mutation cluster regions of the KRAS, EGFR, BRAF and PIK3CA genes and the entire coding region of p53 in the carcinoma, and the expression of ALK fusion was negative. (spandidos-publications.com)

HF exerts in vitro a reversible antiproliferative activity with a block observed in the G1 phase the cell cycle. (nih.gov)
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A rare case after In Vitro Fertilization. (thefreelibrary.com)
EVs suppress proliferation of CD4+ and CD8+ T-cells in vitro and in vivo in OvCa mouse models. (izon.com)

[ 1 ] Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system. (medscape.com)
The recent discovery of fusion oncokinases in a subset of non-small cell lung carcinomas (NSCLCs) is of considerable clinical interest, since NSCLCs that express such fusion oncokinases are reportedly sensitive to kinase inhibitors. (spandidos-publications.com)
Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations. (aad.org)

and similar patterns changes in the expressions of 9 genes involved in the cell cycle/apoptosis, as measured by RT-PCR and capillary electrophoresis. (nih.gov)
Cells were stimulated with nicotine and genes that were differentially expressed upon nicotine stimulation and ID1 depletion were analyzed to identify potential downstream targets of ID1. (springer.com)

We herein report a very rare case of combined small‑cell carcinoma (SmCC) of the hypopharynx, with a squamous cell carcinoma (SqCC) element. (spandidos-publications.com)

In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells. (sciencemag.org)
Concomitant therapy with other anti-neoplastic agents or experimental agents except for small volume radiation to a solitary bony metastasis. (knowcancer.com)
GEP-NENs are divided into three grades based on the Ki-67 index, which is a measurement of the proliferative content displayed by neoplastic cells. (cureus.com)

Until then, little was known of the biological underpinnings of this deadly disease. (tgen.org)
A case of Bowen's disease and small-cell lung carcinoma: long-term consequences of chronic arsenic exposure in Chinese traditional medicine. (thefreelibrary.com)
The patient was diagnosed with Bowen's disease and developed extensive-stage small-cell carcinoma of the lung 10 years and 47 years, respectively, after the onset of arsenic exposure. (thefreelibrary.com)
Our study found that pT3a stage disease following PN for small RCCs (≤4 cm) had similar oncological outcomes to those of pT1a stage. (springer.com)

A few of the less common types are pleomorphic, carcinoid tumor, salivary gland carcinoma, and unclassified carcinoma. (wikipedia.org)

the neoplasms should be diagnosed as mixed endocrine-exocrine carcinoma. (bmj.com)

Expression rate also associated more so with adenocarcinoma histology (39 percent) than in squamous cell carcinoma histology (23 percent). (scienceblog.com)

Small cell carcinoma of the urinary bladder successfully managed with palliative radiotherapy and immunotherapy. (alliedacademies.org)

Compared to non-small cell carcinoma, small cell carcinoma has a shorter doubling time, higher growth fraction, and earlier development of metastases. (wikipedia.org)

Anatomy11

Organisms3

Diseases98

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes34

Disciplines and Occupations2

Information Science4

Health Care13

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. (1/2496)

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise. (2/2496)

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (3/2496)

Combined modality therapy of lung cancer. (4/2496)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (5/2496)

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (6/2496)

Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma. (7/2496)

Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule. (8/2496)

Carcinoma, Small Cell

APUD Cells

Apudoma

Carcinoma, Squamous Cell

Lung Neoplasms

Small Cell Lung Carcinoma

Carcinoma, Renal Cell

Diamond

Sierra Leone

Carcinoma, Neuroendocrine

Neuroendocrine Tumors

Gastrointestinal Neoplasms

Carcinoma, Large Cell

Carcinoid Tumor

Urinary Bladder

Urinary Bladder Neoplasms

Urinary Bladder Diseases

Butylhydroxybutylnitrosamine

Mediastinum

Physicians

Judgment

PubMed

Transients and Migrants

Cellular Phone

Hypercalcemia

Ovary

Dihydrotachysterol

Adenocarcinoma, Bronchiolo-Alveolar

Carcinoma, Non-Small-Cell Lung

Bronchoalveolar Lavage Fluid

Lung

Carcinoma

Cell Line, Tumor

Tumor Cells, Cultured

Mice, Nude

Genes, Tumor Suppressor

Apoptosis

Gene Expression Profiling

Early death during chemotherapy in patients with small-cell lung cancer: derivation of a prognostic index for toxic death and progression. (1/2496)

Defining and analysing symptom palliation in cancer clinical trials: a deceptively difficult exercise. (2/2496)

Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. (3/2496)

Combined modality therapy of lung cancer. (4/2496)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (5/2496)

Fractionated administration of irinotecan and cisplatin for treatment of lung cancer: a phase I study. (6/2496)

Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma. (7/2496)

Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule. (8/2496)

A case report of primary small cell carcinoma of the breast and review of the literature.

Extrapulmonary Small Cell Carcinoma Clinical Presentation: History, Physical Examination

Extrapulmonary Small Cell Carcinoma: Practice Essentials, Pathophysiology, Epidemiology

Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23) | Science

Circumvention of multidrug resistance by a quinoline derivative, MS-209, in multidrug-resistant human small-cell lung cancer...

Primary small cell carcinoma of the urinary bladder.

F-18-FDG-PET/CT imaging of small cell carcinoma of the colon<...

Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer | Lung...

Irinotecan and Carboplatin as First-Line Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer - Full Text...

Imfinzi approved in the EU for the treatment of extensive-stage small cell lung cancer

Cisplatin, Etoposide, and Cyclophosphamide in Treating Patients With Extensive-Stage Small Cell Lung Cancer - Full Text View -...

Racial and Other Disparities Persist Among Patients with Extensive-Stage Small Cell Lung Cancer

CCI-779 in Treating Patients With Extensive-Stage Small Cell Lung Cancer

AID 81529 - Cytotoxicity against NCI tumor panel, HOP-92 non small-cell lung cancer cell line - PubChem

Timing of thoracic radiotherapy in the treatment of extensive-stage small-cell lung cancer: important or not? | Radiation...

Timing of thoracic radiotherapy in the treatment of extensive-stage small-cell lung cancer: important or not? | Radiation...

Limited-stage small-cell lung cancer: Patterns of intrathoracic recurrence and the implications for thoracic radiotherapy<...

FDA Approves Tecentriq plus Chemotherapy for First-Line Treatment of Extensive-Stage Small-Cell Lung Cancer | Personalized...

Bombesin stimulates growth of human small cell lung carcinoma in vivo<...

FDA Approves Durvalumab as Part of a First-Line Combination Regimen for Extensive-Stage SCLC - The ASCO Post

Radiotherapy improves the survival of patients with extensive-disease | CMAR

CD24, a signal-transducing molecule expressed on human B cells, is a major surface antigen on small cell lung carcinomas. -...

Primary Small Cell Anaplastic Carcinoma of the Breast Diagnosed by Fin by M Sebenik, Suresh G. Nair MD et al.

Induction of hydrogen peroxide production and bax expression by caspase- 3(-like) proteases in tyrosine kinase inhibitor...

First-Line Pembrolizumab Added to Standard Chemotherapy Improved Progression-Free Survival in Extensive-Stage Small Cell Lung...

Inhibition of the focal adhesion kinase has anti-tumoral effect in small-cell lung cancer cell lines | OncologyPRO

Novel Therapeutic Targets Identified for Small-cell Lung Cancer - Healthcanal.com : Healthcanal.com

IMFINZI in the Phase III CASPIAN trial - OncologyTube

Influence of Bcl-2 Family Members on the Cellular Response of Small-Cell Lung Cancer Cell Lines to ABT-737 | Cancer Research

Delayed leuko-encephalopathy in survivors with small cell lung cancer<...

Pathway-Based Approaches for Analysis of Genome-Wide Association Studies -A Case Report for Metastatic Small Cell Lung Cancer

Combination Chemotherapy and Imatinib Mesylate in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Research Tools | Yeda Research and Development Company Ltd.

Small Cell Lung Cancer| Oat Cell Cancer | Small Cell Lung Cancer Treatment