Pilomatrixoma: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Sebaceous Gland NeoplasmsAdenocarcinoma, Sebaceous: A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. The tumor is solitary, firm, somewhat raised, more or less translucent, and covered with normal or slightly verrucose epidermis. It may be yellow or orange. The face and scalp are the commonest sites. The growth can be slow or rapid but metastasis is uncommon. Surgery cures most of the cases. (From Rook et al., Textbook of Dermatology, 4th ed, pp2403-4)Hair Diseases: Diseases affecting the orderly growth and persistence of hair.Neoplasms, Adnexal and Skin Appendage: Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.Neoplasms, Basal Cell: Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.Dermatology: A medical specialty concerned with the skin, its structure, functions, diseases, and treatment.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Carcinoma, Skin Appendage: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)Parathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Ectodysplasins: Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.Feathers: Flat keratinous structures found on the skin surface of birds. Feathers are made partly of a hollow shaft fringed with barbs. They constitute the plumage.Integumentary System: The outer covering of the body composed of the SKIN and the skin appendages, which are the HAIR, the NAILS; and the SEBACEOUS GLANDS and the SWEAT GLANDS and their ducts.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.TartratesLevalbuterol: The R-isomer of albuterol.Drug Incompatibility: The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.Ipratropium: A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.Tosyl CompoundsAnilidesNitriles: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.Androgen Antagonists: Compounds which inhibit or antagonize the biosynthesis or actions of androgens.Liver Diseases: Pathological processes of the LIVER.Androgen Receptor Antagonists: Compounds that bind to and inhibit the activation of ANDROGEN RECEPTORS.Receptors, Androgen: Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.Injections: Introduction of substances into the body using a needle and syringe.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Injections, Subcutaneous: Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.Injections, Intralesional: Injections introduced directly into localized lesions.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Injections, Intraperitoneal: Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.Confidentiality: The privacy of information and its protection against unauthorized disclosure.NevadaNeoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Medical Laboratory Science: The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.Laboratory Infection: Accidentally acquired infection in laboratory workers.Laboratories: Facilities equipped to carry out investigative procedures.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Adnexal Diseases: Diseases of the uterine appendages (ADNEXA UTERI) including diseases involving the OVARY, the FALLOPIAN TUBES, and ligaments of the uterus (BROAD LIGAMENT; ROUND LIGAMENT).Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Sarcoma, Clear Cell: A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)

Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages. (1/25)

Familial cylindromatosis (turban tumor syndrome; Brooke-Spiegler syndrome) (OMIM numbers 123850, 132700, 313100, and 605041) is a rare autosomal dominantly inherited tumor syndrome. The disorder can present with cutaneous adnexal tumors such as cylindromas, trichoepitheliomas, and spiradenomas, and tumors preferably develop in hairy areas of the body such as head and neck. In affected families, mutations have been demonstrated in the CYLD gene located on chromosome 16q12-13 and reveal the characteristic attributes of a tumor suppressor. Here, we studied familial cylindromatosis in a multigeneration family of German origin. Clinically, some individuals only revealed discrete small skin-colored tumors localized in the nasolabial region whereas one family member showed expansion of multiple big tumors on the trunk and in a turban-like fashion on the scalp. Histologically, cylindromas as well as epithelioma adenoides cysticum were found. We detected a frameshift mutation in the CYLD gene, designated 2253delG, underlying the disorder and were able to show that a single mutation can result in distinct clinical and histologic expression in familial cylindromatosis. The reasons for different expression patterns of the same genetic defect in this disease remain elusive, however. Identification of mutations in the CYLD gene enable us to rapidly confirm putative diagnoses on the genetic level and to provide affected families with genetic counseling.  (+info)

Piloleiomyoma--a report of five cases. (2/25)

Piloleiomyomas are uncommon smooth muscle neoplasms of the skin with a few reproted cases in Indian literature (1,2,3,4,5). They are often misdiagnosed clinically. A correct biopsy report is important because patients may have to be managed medically since surgery is associated with a high rate of recurrence. The classical histologic findings, and Masson's stain to confirm the smooth muscle origin aids in the correct diagnosis.  (+info)

Squamous cell carcinoma in situ arising in mature cystic teratoma. (3/25)

Mature cystic teratomas of ovary are common tumors. A few may exhibit malignant degeneration, most of these being invasive squamous cell carcinoma. We report a rare case of pure squamous cell carcinoma in situ in benign cystic teratoma.  (+info)

A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome. (4/25)

Brooke-Spiegler syndrome (BSS, familial cylindromatosis or turban tumor syndrome) is an inherited disease characterized by neoplasms of the skin appendages such as cylindroma, trichoepithelioma, and spiradenoma. The disease has been mapped to 16q12-13, and mutations in the CYLD gene have been identified in families with this disorder. Of interest, multiple familial trichoepithelioma (MFT) has been described as a distinct disorder characterized by the familial occurrence of trichoepitheliomas. MFT has been mapped to 9p21; however, to date a candidate gene has not been identified. In this report, we describe a four-generation family with BSS presenting predominantly with trichoepitheliomas (resembling MFT phenotype). We identified a novel missense mutation in the CYLD gene, designated E474G, in the affected individuals of this family. Our findings exemplify clinical heterogeneity within BSS and extend the body of evidence that mutations in CYLD are implicated in this disease. Although not conclusive, these findings suggest that BSS and MFT may represent a single entity.  (+info)

Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. (5/25)

Brooke-Spiegler syndrome (BSS), familial cylindromatosis (FC), and multiple familial trichoepithelioma (MFT), originally described as distinct entities, share overlapping clinical findings. Patients with BSS are predisposed to multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. FC, however, is characterized by cylindromas and MFT by trichoepitheliomas as the only tumor type. These disorders have recently been associated with mutations in the CYLD gene. In this report, we describe three families with BSS, one with FC, and two with MFT phenotypes associated with novel and recurrent mutations in CYLD. We provide evidence that these disorders represent phenotypic variation of a single entity and lack genotype-phenotype correlation.  (+info)

Sex steroid hormone receptors in human skin appendage and its neoplasms. (6/25)

Sex steroids have been postulated to influence pathophysiology of human skin through various skin appendages. The presence of sex steroid receptors has been also reported in adnexal tumors but its details still remained unknown. Therefore, in this study, we immunolocalized sex steroid receptor protein (estrogen receptor (ER)alpha, ERbeta, progesterone receptor (PR)A, PRB and androgen receptor (AR)) in 23 cases of non-pathological skin (male: 10, female: 13) and in 50 cases of skin adnexal tumors (male 24, female 26; 38 benign and 12 malignant). ERalpha immunoreactivity was detected exclusively in basal cells of sebaceous glands of non-pathological skin. AR and PRB immunoreactivity was detected in both differentiated and basal cells of sebaceous gland. AR and ERbeta immunoreactivity was also detected in sebaceous and eccrine sweat glands but not in outer root sheath of hair follicles. In sebaceous gland neoplasms, the number of ERalpha positive cases was significantly lower in skin appendage neoplasms than non-pathological skin. ERbeta immunoreactivity was not detected in any of sebaceous gland neoplasms examined. There were no significant differences in PRA, PRB and AR immunoreactivity between non-pathological sebaceous gland and its neoplasm. In sweat gland neoplasms, the number of AR positive cases was significantly lower in benign neoplasms than their non-pathological counterpart. Therefore sex steroids are considered to play important roles in regulation of non-pathological skin appendage function and pathogenesis and/or development of its neoplasm. In addition, the status of the great majority of sex steroid hormone receptors was maintained throughout the process of neoplastic transformation of skin appendages, except for AR and ERalpha in sweat and sebaceous gland neoplasms.  (+info)

Genetics of skin appendage neoplasms and related syndromes. (7/25)

In the past decade the molecular basis of many inherited syndromes has been unravelled. This article reviews the clinical and genetic aspects of inherited syndromes that are characterised by skin appendage neoplasms, including Cowden syndrome, Birt-Hogg-Dube syndrome, naevoid basal cell carcinoma syndrome, generalised basaloid follicular hamartoma syndrome, Bazex syndrome, Brooke-Spiegler syndrome, familial cylindromatosis, multiple familial trichoepitheliomas, and Muir-Torre syndrome.  (+info)

Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. (8/25)

Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff-positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as "clear-cell hidradenocarcinoma" and "follicular stem cell carcinoma." The authors propose the designation "cutaneous clear cell adnexal carcinoma."  (+info)

*Carcinoma

Adenoid cystic carcinoma (M8312/3) Renal cell carcinoma (M8312/3) Grawitz tumor (8390-8420) Adnexal and Skin appendage ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ... Carcinoma is a type of cancer that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a ... A history of cigarette smoking is the most common cause of large cell carcinoma. The term carcinoma has also come to encompass ...

*International Classification of Diseases for Oncology

Skin appendage tumor, benign Adnexal tumor, benign M8390/3 Skin appendage carcinoma (C44._) Adnexal carcinoma M8391/0 ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... Renal cell carcinoma, spindle cell M8319/3 collecting duct carcinoma (C64.9) Bellini duct carcinoma Renal carcinoma, collecting ... NOS Condylomatous carcinoma Verrucous squamous cell carcinoma Verrucous epidermoid carcinoma Warty carcinoma M8052/0 Squamous ...

*List of MeSH codes (C04)

... carcinoma, skin appendage MeSH C04.557.470.565 --- neoplasms, basal cell MeSH C04.557.470.565.165 --- carcinoma, basal cell ... carcinoma, verrucous MeSH C04.557.470.550 --- neoplasms, adnexal and skin appendage MeSH C04.557.470.550.105 --- adenocarcinoma ... carcinoma, skin appendage MeSH C04.557.470.200.025.450 --- cholangiocarcinoma MeSH C04.557.470.200.025.455 --- choriocarcinoma ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ...

*List of cutaneous conditions

... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ... Conditions of the skin appendages are those affecting the glands of the skin, hair, nails, and arrector pili muscles. Acne ... Peeling skin syndrome (acral peeling skin syndrome, continual peeling skin syndrome, familial continual skin peeling, ... The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the " ...

*Keratin 8

1991). "Immunohistochemical demonstration of keratins 8 and 14 in benign tumours of the skin appendage". Virchows Archiv A. 418 ... Antibodies to CK8 (e.g. CAM 5.2) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the ... such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph ... In normal tissue, it reacts mainly with secretory epithelia, but not with squamous epithelium, such as that found in the skin, ...

*Myiasis

Once hatched, the larvae then lacerate the skin with their mouthparts, causing open sores. Once the skin has been breached, the ... Namazi MR, Fallahzadeh MK (November 2009). "Wound myiasis in a patient with squamous cell carcinoma". ScientificWorldJournal. 9 ... probing appendages protruding on either side of the "mouth". Maggot therapy - also known as maggot debridement therapy (MDT), ... where skin is removed from young animals to tighten remaining skin - leaving it less prone to fly attack. To prevent myiasis in ...

*Keratin

It is the key structural material making up hair, horns, claws, hooves, and the outer layer of human skin. Keratin is also the ... which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. The only ... Epidermolytic hyperkeratosis Steatocystoma multiplex Keratosis pharyngis Rhabdoid cell formation in Large cell lung carcinoma ... Cells in the epidermis contain a structural matrix of keratin, which makes this outermost layer of the skin almost waterproof, ...

*Scrotal ultrasound

Embryonal cell carcinoma Embryonal cell carcinomas, a more aggressive tumor than seminoma usually occurs in men in their 30s. ... Four testicular appendages have been described: the appendix testis, the appendix epididymis, the vas aberrans, and the ... 30], reactive hydrocele and skin thickening of the scrotum is common, increased peripheral vascular flow may be found around ... Clinically pain may occur with torsion of either appendage. Physical examination showed a small, firm nodule is palpable on the ...

*Desmoplasia

... malignant melanoma Desmoplastic squamous cell carcinoma Morpheaform basal cell carcinoma Microcystic adnexal carcinoma ... and no appendages. This is distinguished from desmoplasia in the organization of the tissue, the appendages, and orientation of ... A mixture of these cell types is recognized, normally, as a wound, as in the example of a cut to the skin. Metastasis is an ... El-Torkey, M; Giltman, LI; Dabbous, M (1985). "Collagens in scar carcinoma of the lung". The American Journal of Pathology. 121 ...

*Hair loss

Tumours and skin outgrowths also induce localized baldness (sebaceous nevus, basal cell carcinoma, squamous cell carcinoma). ... Vary JC, Jr (November 2015). "Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis". The Medical clinics of ... Scalp reduction is the process is the decreasing of the area of bald skin on the head. In time, the skin on the head becomes ... It should not be used when cancer is present in the skin of the scalp or for lymphoma or leukemia. There are generally only ...

*Hedgehog signaling pathway

... prostate and skin. Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with ... Hedgehog has roles in larval body segment development and in formation of adult appendages. During the formation of body ... Diseases associated with the malfunction of this pathway include basal cell carcinoma. The Hedgehog signaling pathway is one of ... Furthermore, overexpression of PTCH2 does not replace mutated PTCH1 in basal cell carcinoma. In invertebrates, just as in ...

*Cystic fibrosis transmembrane conductance regulator

In the skin CFTR is strongly expressed in the sebaceous and eccrine sweat glands. In the eccrine glands, CFTR is located on the ... "Primary hepatocellular carcinoma with severe hypoglycemia: involvement of insulin-like growth factors". Liver. 12 (2): 90-3. ... and CFTR in the human epidermis and epidermal appendages". Histochemistry and Cell Biology. 147 (6): 733-748. doi:10.1007/ ...

*List of diseases (C)

... syndrome Carbon baby syndrome Carbonic anhydrase II deficiency Carcinoid syndrome Carcinoma of the vocal tract Carcinoma, ... total congenital Cataract-glaucoma CATCH 22 syndrome Catecholamine hypertension Catel-Manzke syndrome Caudal appendage deafness ... jaundice Congenital rubella Congenital short bowel Congenital short femur Congenital skeletal disorder Congenital skin disorder ... squamous cell of head and neck Carcinoma, squamous cell Carcinophobia Cardiac amyloidosis Cardiac and laterality defects ...
Multiple familial trichoepithelioma (also known as Brooke-Spiegler syndrome and epithelioma adenoides cysticum) is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face. The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene. Types include: Brooke-Spiegler syndrome is a condition where multiple skin tumors develop from skin structures. Tumors commonly occurring in this syndrome include spiradenomas, trichoepitheliomas, and cylindromas. The tumors are generally benign, but may become malignant. Affected individuals are also at increased risk of developing tumors in tissues other than skin - particularly benign or malignant tumors of the salivary glands. Tumours in Brooke-Spiegler typically appear in early adulthood ...
... is a rare type of cancer that usually develops in areas of the body where sweat is produced (sweat glands). The largest of these sweat-producing sites and also the most common location where microcystic adnexal carcinoma develops is the central face. The cancer forms when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Microcystic adnexal carcinoma may also occur in the general head and neck regions. Some of these cancerous cells can break off and spread ("metastasize") to other parts of the body and grow there.. Microcystic adnexal carcinoma most commonly occurs in adults between the ages of 40 and 60, though it can appear in all age groups. Factors that may increase the risk of developing microcystic adnexal carcinoma include excess exposure to sunlight, sunburn, and a family history of skin cancer. The most common symptoms of microcystic adnexal carcinoma include redness, inflammation, and irritation of ...
Multiple familial trichoepithelioma can be caused by mutations in the CYLD gene. This gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that help protect cells from self-destruction (apoptosis) in response to certain signals. In regulating the action of nuclear factor-kappa-B, the CYLD protein allows cells to respond properly to signals to self-destruct when appropriate, such as when the cells become abnormal. By this mechanism, the CYLD protein acts as a tumor suppressor, which means that it helps prevent cells from growing and dividing too fast or in an uncontrolled way.. People with CYLD-related multiple familial trichoepithelioma are born with a mutation in one of the two copies of the CYLD gene in each cell. This mutation prevents the cell from making functional CYLD protein from the altered copy of the gene. However, enough protein is usually produced from the other, normal copy of the gene to ...
Blake , PW, Toro , JR. "Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling". Hum Mutat. vol. 30. 2009. pp. 1025-36. (A comprehensive review about the clinical features, molecular genetics, and the animal models of Brooke-Spiegler syndrome.). Layegh , P, Sharifi-Sistani , N, Abadian , M, Moghiman , T. "Brooke-Spiegler syndrome". Indian J Dermatol Venereol Leprol. vol. 74. 2008. pp. 632-4. (A case report describing a patient diagnosed as Brooke-Spiegler syndrome.). Kazakov , DV, Zelger , B, Rütten , A, Vazmitel , M, Spagnolo , DV, Kacerovska , D. "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome". Am J Surg Pathol. vol. 33. 2009. pp. 705-19. (An article describing a series of 24 malignant neoplasms arising in preexisting benign spiradenoma ...
Dermatopathology reference describes microcystic adnexal carcinoma histopathology including histologic features and provides links to additional medical references.
Brooke-Spiegler Syndrome. Quyn Sherrod, MD; Miguel Gutierrez, MD; Keith Carlson, MD UCLA/WLA VA Division of Dermatology David Geffen School of Medicine Los Angeles, California. History. 39 year-old, healthy, Caucasian male Multiple lesions on face and scalp beginning at 10 years old...
COPYRIGHT (C) 2016 KISTI. ALL RIGHTS RESERVED.. 대전광역시 유성구 대학로 245 한국과학기술정보연구원TEL : 042.869.1234 서울시 동대문구 회기로 66NDSL고객센터 : 080.969.4114E-mail : [email protected] ...
CYLD is a negative regulator of TRAF2 and NF-kappa B signaling pathway. CYLD has a deubiquitinating activity that is directed towards non-Lys48-linked polyubiquitin chains. Defects in CYLD are the cause of familial cylindromatosis, a highly tumor type-specific disorder ...
Looking for online definition of Brooke-Fordyce trichoepithelioma in the Medical Dictionary? Brooke-Fordyce trichoepithelioma explanation free. What is Brooke-Fordyce trichoepithelioma? Meaning of Brooke-Fordyce trichoepithelioma medical term. What does Brooke-Fordyce trichoepithelioma mean?
The Role of Bcl-2, CD10 and CD34 Expression in Differentiation between Basal Cell Carcinoma and Trichoepithelioma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of patterns. Here, we first introduce the basics of pattern formation and their possible biological basis. We then discuss different categories of skin patterns and their potential underlying molecular mechanisms. Some patterns, such as the lines of Blaschko and Naevus, are based on cell lineage and genetic mosaicism. Other patterns, such as regionally specific skin appendages, can be set by distinct combinatorial molecular codes, which in turn may be set by morphogenetic gradients. There are also some patterns, such as the arrangement of hair follicles (hair whorls) and fingerprints, which involve genetics as well as stochastic epigenetic events based on physiochemical principles. Many appendage primordia are laid out in developmental waves. In the adult, some patterns, such as those involving cycling hair ...
Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early stages in embryonic mammary development strikingly resemble analogous steps in
A type 1 excludes note is a pure excludes. It means "not coded here". A type 1 excludes note indicates that the code excluded should never be used at the same time as L60-L75. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition ...
Dermatology is a specialty that deals with all illnesses that occur in any part of the skin, spinous mucosal membrane, finger and toe nails, hair and other skin appendages. The Department of Dermatology treats and provides assistance to patients through comprehensive research in various top-notch fields such as immunology, genetics and molecular biology as well as basic medicine. ...
Looking for online definition of desmoplastic trichoepithelioma in the Medical Dictionary? desmoplastic trichoepithelioma explanation free. What is desmoplastic trichoepithelioma? Meaning of desmoplastic trichoepithelioma medical term. What does desmoplastic trichoepithelioma mean?
To the Editor:. Misago et al1 have recently published 6 cases of infundibular (follicular) and 2 examples of infundibulocystic squamous cell carcinoma and have redefined the original criteria for both follicular squamous cell carcinoma and infundibulocystic squamous cell carcinoma.2,3 They propose that the term infundibular squamous cell carcinoma was synonymous with follicular squamous cell carcinoma, and infundibulocystic carcinoma was a distinctive tumor sharing features with microcystic adnexal carcinoma.. In the initial description of 16 examples of follicular squamous cell carcinoma by Diaz-Cascajo et al,2 these squamous cell carcinomas arose in follicles and formed nodular tumors that replaced the follicles but did not demonstrate follicular differentiation even when the tumor infiltrated the surrounding tissue. From a clinical perspective, follicular squamous cell carcinomas in the original study were described as dermal nodules that did not resemble keratoacanthoma and were diagnosed as ...
Less Common Skin Cancers. Merkel Cell Carcinoma is a rare and aggressive form of skin cancer. It arises from Merkel cells in the lower part of the epidermis. Merkel cells are similar to nerve cells and give the skin "touch" sensation. Treatment involves a team approach from physicians with significant experience with the disease.. Atypical Fibroxanthoma is thought to arise from the dermis, which is deeper than the epidermis, the source of most other skin cancers. It classically appears on the face or scalp as a reddish, sometimes glistening plaque (broad, raised area on the skin).. Microcystic Adnexal Carcinoma is thought to be derived from cells that produce the adnexal structures, such as hair follicles and sweat glands in the skin. It classically occurs on the face. It may have a deceivingly benign appearance and may be mistaken for a common melanocytic nevus (mole ...
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful ...
Skin appendages (or adnexa) are skin-associated structures that serve a particular function including sensation, contractility, lubrication and heat loss. In humans, some of the more common skin appendages are hairs (sensation, heat loss, filter for breathing, protection), arrector pilli (smooth muscles that pull hairs straight), sebaceous glands (secrete sebum onto hair follicle, which oils the hair), sweat glands (can be sweat secreted with strong odour (apocrine) or with a faint odour (eccrine)) and nails (protection). Skin appendages are derived from the skin, and are usually adjacent to it. Types of Appendages include hair, glands, and nails. Sweat Glands are distributed all over the body except nipples and outer genitals. Although the nipples do have the mammary glands, these are known as modified sweat glands. Sebaceous Glands are typically found in the opening shaft of hair. They are not on the palms of the hands or the soles of the feet. These glands secret an antibacterial moisture ...
Hum Pathol. 2009 Oct;40(10):1499-503. doi: 10.1016/j.humpath.2009.02.015. Epub 2009 May 19. Case Reports; Research Support, Non-U.S. Govt
Lin, C.M and Jiang, T.X. and Baker, Ruth E. and Maini, P. K. and Widelitz, R. B. and Chunong, C.M. (2009) Spots & stripes: pleomorphic patterning of stem cells via p-ERK-depenendent cell chemotaxis shown by feather morphogenesis & mathematical simulation. Developmental Biology, 334 (2). pp. 369-382. Lin, C. and Jiang, T. and Baker, Ruth E. and Maini, P. K. and Hughes, M. and Widelitz, R. B. and Chuong, C. (2008) Periodic patterning stem cells and induction of skin appendages: p-ERK-dependent mesenchymal condensation is coupled with Turing mechanism to convert stripes to spots. Journal of Investigative Dermatology, 128 (S1). S156. Widelitz, R. B. and Baker, Ruth E. and Plikus, M. V. and Lin, C. and Maini, P. K. and Paus, R. and Chuong, C. M. (2006) Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Research (Part C),, 78 (3). pp. 280-291. ...
Allergy bumps in eyes - I have little white bumps under my eyes, have allergies, I take medicine but what can I do to make the white bumps go away? White bumps. It is unclear from your description whether these are not normal skin appendages. You can try warm compresses for 10 minutes at a time. Otherwise best seen in person.
Background: Skin Adnexal Tumours (SATs ) are large and divergent group of tumours which are classified based on their appendageal differentiation into eccrine,follicular,sebaceous and apocrine.They pose daunting diagnostic challenges to both clinicians and pathologists alike.This study aims to evaluate the histopathological charecterestics of skin adnexal neoplasms and correlate with their clinical profile.Methods : This is a retrospective study of skin adnexal tumours (28 cases) diagnosed on histopathological examination over a period of two years .( January 2014 to December 2015 ).Results: Skin adnexal tumours are uncommon lesions with an incidence of 0.27%.These tumours were common in the 51 to 60 age group and showed a female preponderance. Head and neck region particularly the scalp was commonly involved. Benign tumours were more common (78.6% ) than the malignant ones (21.4%). .Sweat gland tumours constituted the largest group (61%) followed by hair follicle tumours (21%)and sebaceous ...
This study aims to evaluate a new ointment to treat an inherited skin tumour condition called cylindromatosis. Patients from families with this condition carry an error in their DNA (CYLD mutation) that results in the development of multiple skin tumours on the face, scalp and trunk. These tumours are disfiguring, can be painful, and may ulcerate and bleed. Surgery is the only available treatment, and up to 1 in 4 patients with this condition undergo removal of their entire scalp to manage this condition. We have recently discovered an abnormal signal in the tumour cells called TRK. This signal is recognised to give tumour cells the ability to survive, and in laboratory tests blocking it with drugs called TRK inhibitors results in the tumour cells dying. We propose a study of an ointment form of TRK inhibitor as a means to reduce tumour growth in these patients. We have partnered with a drug company (Creabilis) who have already produced this ointment (called CT327) for trials in skin conditions. ...
Drosophila CYLD protein: ortholog of the human cylindromatosis tumor suppressor protein; involved in a broad range of functions associated with fat homeostasis and host defence; RefSeq NM_164909.1; NP_723554.1
Growing evidence in clinical studies suggests that ubiquitin systems are greatly related to the progression of atherosclerosis, particularly in relation to inflammation and cell proliferation. However, there were few reports referred to molecular mechanisms of vascular remodeling related to ubiquitin systems. NF-κB is an important transcriptional factor which plays central roles in pathogenesis of atherosclerosis. Thus, in this study, we focused on CYLD which is a NF-κB-related deubiquitinating enzyme and may be a therapeutic target of tumor in cancer research. From Northern blot and immunohistology, CYLD was endogenously expressed in vascular endothelial cells (EC) and smooth muscle cells (VSMC). Interestingly, the treatment of TNF-α significantly increased CYLD expression in EC and VSMC. CYLD was markedly induced in the neointima of the balloon-injured carotid arteries, and was also present in atherosclerotic lesions from human carotid arteries. Thus, the expression of CYLD could be ...
aka Mature cystic teratoma Contains tissue from all 3 germ cell layers hence have all kinds of tissue - fat, hair, skin, teeth, cartilage, etc 10% bilateral Complications: torsion haemorrhage malignant degeneration - rare
A mature cystic teratoma of the ovary is called a dermoid cyst. This patient presented with a palpable lump per abdomen. The initial ultrasound scan showed the characteristic sonographic features of an ovarian dermoid cyst. CT abdomen was done la...
The skin is the largest organ of the human body, comprising approximately 17% of the body weight. An average adult would have a skin total surface area of around 1.7 square meters. The thickness of the skin varies depending on the site where it resides, ranging from 3mm to 6mm. The skin is the most visible and exposed organ of the body, and hence it is the first line of defense of the body against the harsh environment.. The structure of the skin comprises of three main layers, namely the epidermis, the dermis and the hypodermis. There are also skin appendages that play their own respective roles in the skin. Each make-up of each layer will be described below.. EPIDERMIS. The epidermis is the most dynamic layer among all the layers of the skin. Despite being the thinnest layer, it is actually the most important layer among all. The epidermis consists of 5 sub-layers, that will be listed below:. (a) Stratum germinativum (basal cell layer) - This is the deepest layer composed of keratinocytes. ...
A group of hereditary disorders involving tissues and structures derived from the embryonic ectoderm. They are characterized by the presence of abnormalities at birth and involvement of both the epidermis and skin appendages. They are generally nonprogressive and diffuse. Various forms exist, including anhidrotic and hidrotic dysplasias, FOCAL DERMAL HYPOPLASIA, and aplasia cutis congenita.. ...
Results: MCT comprised 230 (57.6%) out of total 399 cases of ovarian neoplasms. The age range of the patients was 8-74 years. The sizes of the tumors ranged from 2.5-20cm. 12% of the cases were bilateral. Ischemic modifications, presumably due to torsion, were noted in 10% of the cases, mostly in tumors larger than 10cm. None of the tumors of less than 5cm presented with signs of torsion. Malignant transformation was present in seven (3%) cases and was seen especially in older patients and in larger tumors. Squamous cell carcinoma was the most common malignant tumor seen in five cases. One case was a mixed germ cell tumor with components of MCT and yolk sac tumor. ...
Discussion Mature cystic teratoma (dermoid cysts), accounts for approximately 25% of all ovarian tumors. They are unilateral in 88% of the cases and present with symptoms related to the mass lesion. They contain a varied mixture of ectodermal, mesodermal and endodermal structures distributed in an organized fashion.[1] The first description of pneumatosis cystoides-like appearance in a mature cystic teratoma was given by Maudsley and Zakhour in a 29 year old primigravida in 1988.[2] Subsequently, two case studies with 13 and 7 cases respectively have been reported.[34] These multicystic structures have been variably called as sieve-like areas and Pneumatosis cystoides-like appearances by various authors.[234] The multicystic structures can occur in any age group, but they are generally found in tumors from older patients.[5] Maudsley and Zakhour suggested these cysts to be gas cysts, as on routine staining and immunohistochemistry neither cyst contents, nor endothelial lining were identified.[2] ...
Read "Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes, Archives of Gynecology and Obstetrics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Genetic wildlife monitoring is increasingly carried out on the basis of non-invasively collected samples, whereby the most commonly used DNA sources are skin appendages (hairs, feathers) and faeces....
Dutch researcher Sebastian Nijman has discovered new genes which are i...Patients with the very rare genetic condition cylindromatosis develop ...People with this disease have a mutated form of the protein CYLD. Nijm...An important implication of this research is that inhibition of the NF...Fanconi anaemia ...,Function,of,new,cancer,genes,discovered,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Austin Texas dermatologists Dr. Miriam Hanson and Dr. Adam Mamelak discuss the appearance, health implications and treatment of a Pilar Cyst in the skin.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Full Text - CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes, protects from premature aging and cancer. We have generated transgenic mice expressing the mutant CYLDC/S protein, lacking its deubiquitinase function, under the control of the keratin 5 promoter, the K5-CYLDC/S mice. These mice express the transgene in different organs, including those considered to be more susceptible to aging, such as skin and thymus. Our results show that K5-CYLDC/S mice exhibit epidermal, hair follicle, and sebaceous gland alterations; and, importantly, they show signs of premature aging from an early age. Typically, 3-month-old K5-CYLDC/S mice exhibit a phenotype characterized by alopecia and kyphosis, and, the histological examination reveals that transgenic mice show signs
cyld displays a dominant genetic linkage to multiple types of cutaneous adnexal tumors that often develop in bulky clusters in the head, neck, trunk, and pubic areas (10, 37). Although predominantly benign (10), these tumors are painful and disfiguring, can undergo malignant transformation with metastasis over time, and eventually lead to mortality (38-41). Thus, the malignant features of the tumors developed on K14-CYLDm transgenic mice are in line with the clinical manifestations seen in patients. Our transgenic tumor models allowed us to define JNK/AP1 signaling cascade as a key regulator in CYLDm-driven epidermal malignancy.. Cyld loss of function is not only relevant to cutaneous adnexal tumors but also to many other cancers including SCC (22,42). It is worth noting that cyld−/− mice are sensitive to chemically induced carcinogenesis, but the tumors developed on these mice are not more malignant than those of WT mice (22). We predict that the differential tumor growth phenotypes ...
Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol. 1978 Mar; 69(3):289-98.. ...
clear cell hidradenoma breast Malignant clear cell hidradenoma is a rare oncologic entity and has only rarely been reported to occur in the breast. The rarity of the tumor, inconsistent nomenclature and histologic similarities with other tumors creates a diagnostic challenge [2, 4. clear cell hidradenoma breast Clear cell hidradenoma (CCH) is an uncommon skin adnexal tumor arising from eccrine glands. Although several kind of skin adnexal tumors arise in the breast tissue, CCH of the breast is an extremely rare entity. Failure to identify its
The epidermis and dermis are separated by the basement membrane zone. Anchoring fibrils connect these two layers. The dermis consists of a superficial thin layer called the papillary dermis and a deep, dense layer called the reticular dermis. The primary cell of the dermis is the fibroblast that produces the collagen, elastic fibers, and ground substance that compose the bulk of the dermis. Inflammatory cells migrate through the ground substance beneath the dermis, a large plexus of arterioles and venules called the subdermal plexus. This plexus further branches into superficial smaller vessels called the papillary plexus. The skin appendages, sebaceous glands, sweat glands, and hair follicles all lie within the dermis. ...
Purpose: The hypermetabolic nature of cancer cells, especially their increased reliance on aerobic glycolysis which has been associated with more aggressive phenotype, is considered metabolic hallmarks of cancer cells including oral squamous cell carcinoma (OSCC) cells. However, its precise mechanisms remain unknown. Cylindromatosis (CYLD) is recognized as a tumor suppressor gene whereas little is available about its impact on cancer progression. Our unpublished data showed that lower CYLD expression was associated with poor prognosis in OSCC patients. The objective of our study was to address specific contributions of CYLD to the signature metabolic features of OSCC cells.. Materials and methods: We determined the level of glucose consumption as well as lactate production to evaluate the effects of CYLD knockdown by siRNA on aerobic glycolysis in human OSCC cell lines. In addition, we measured extracellular acidification and oxygen consumption rates in OSCC cells by using XF Extracellular Flux ...
Teratomas are germ cell tumors commonly composed of multiple cell types derived from one or more of the 3 germ layers. Inconsistent nomenclature often confuses discussions of various subtypes of teratomas.

Carcinoma, Skin Appendage | Profiles RNSCarcinoma, Skin Appendage | Profiles RNS

Skin Appendage" by people in this website by year, and whether "Carcinoma, Skin Appendage" was a major or minor topic of these ... "Carcinoma, Skin Appendage" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Carcinoma, Skin Appendage" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Carcinoma, Skin Appendage". ...
more infohttps://profiles.umassmed.edu/display/116330

adnexal skin appendage tumour 2005:2010[pubdate] *count=100 - BioMedLib™ search engineadnexal skin appendage tumour 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Carcinoma, Basal Cell / pathology. Neoplasms, Adnexal and Skin Appendage / pathology. Skin Neoplasms / pathology ... MeSH-major] Carcinoma, Skin Appendage / radiotherapy. Head and Neck Neoplasms / radiotherapy. Radiotherapy, Adjuvant. Skin ... Carcinoma, Basal Cell / metabolism. Mucin-1 / metabolism. Neoplasms, Adnexal and Skin Appendage / metabolism. Skin Neoplasms / ... Carcinoma, Skin Appendage / pathology. Humans. Syringoma / pathology. *. [Email] Email this result item Email the results to ...
more infohttp://www.bmlsearch.com/?kwr=adnexal+skin+appendage+tumour+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Carcinoma, Skin Appendage Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
more infohttps://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Carcinoma,+Skin+Appendage&parentid=33383&catid=33360

Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)

Categories: Carcinoma, Skin Appendage Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
more infohttps://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Carcinoma,+Skin+Appendage&parentid=1961&catid=33359

Brooke-Spiegler Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsBrooke-Spiegler Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Carcinoma, Skin Appendage 45 Eccrine Dermal Cylindroma 74 Skin Appendage Carcinoma 17 ... skin,NS,carcinoma,basal cell carcinoma c.5825G,A. p.G1942E. 16:72796857-72796857. 0. ... skin,NS,carcinoma,basal cell carcinoma c.11050G,A. p.D3684N. 16:72787226-72787226. 0. ... skin,NS,carcinoma,basal cell carcinoma c.1991C,T. p.S664F. 16:72958155-72958155. 0. ...
more infohttps://www.malacards.org/card/brooke_spiegler_syndrome

basal cell carcinoma with adnexal differentiation 2005:2010[pubdate] *count=100 - BioMedLib™ search enginebasal cell carcinoma with adnexal differentiation 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / chemistry. Carcinoma, Skin Appendage / pathology. Cell ... Carcinoma, Skin Appendage / diagnosis. Skin / pathology. Skin Neoplasms / diagnosis. *[MeSH-minor] Biopsy. Carcinoma, Squamous ... MeSH-major] Carcinoma, Basal Cell / pathology. Carcinoma, Skin Appendage / pathology. Mohs Surgery. Skin Neoplasms / pathology ... Carcinoma, Basal Cell / diagnosis. Carcinoma, Skin Appendage / diagnosis. Skin Neoplasms / diagnosis. Trans-Activators / ...
more infohttp://www.bmlsearch.com/?kwr=basal+cell+carcinoma+with+adnexal+differentiation+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Davud Sirjanis Profile | Stanford ProfilesDavud Sirjani's Profile | Stanford Profiles

Carcinoma, Skin Appendage. Academic Appointments. * Clinical Associate Professor, Otolaryngology (Head and Neck Surgery) ... Oral Squamous Cell Carcinoma Mimicking Peri-Implantitis CLINICAL ADVANCES IN PERIODONTICS Chainani-Wu, N., Chang, C., Sim, C., ... Oropharyngeal squamous cell carcinoma incidence and mortality trends in the United States, 1973-2013. The Laryngoscope Megwalu ... Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma. Otolaryngology--head and neck surgery : official ...
more infohttps://profiles.stanford.edu/davud-sirjani

Dermatology - Research Output
     - Mayo ClinicDermatology - Research Output - Mayo Clinic

Skin Appendage Carcinoma Mohs Surgery Skin Neoplasms Head and Neck Neoplasms Retrospective Studies ... Aggressive skin cancer in chronic GvHD after allogeneic hematopoietic cell transplantation. Lehman, J., Baum, C., Moore, E., ... Mohs micrographic surgery in the treatment of trichilemmal carcinoma: The Mayo Clinic experience. Tolkachjov, S. N., Hocker, T ... Potential diagnostic pitfall in direct immunofluorescence evaluation for vasculitis in skin biopsies: Fluorescent secretory ...
more infohttps://mayoclinic.pure.elsevier.com/en/organisations/dermatology/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Fletter

Code System ConceptCode System Concept

Skin appendage carcinoma (morphologic abnormality). Code System Preferred Concept Name. Skin appendage carcinoma (morphologic ... Malignant neoplasm, primary (morphologic abnormality) {86049000 , SNOMED-CT } Malignant skin appendage tumor (morphologic ... Skin appendage carcinoma Current Synonym true false 106380017 Adnexal carcinoma Current Synonym true false ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=64000002

Value Set Concept DetailsValue Set Concept Details

Skin appendage carcinoma (morphologic abnormality) Code System Concept Status. Published. Code System Preferred Concept Name. ...
more infohttps://phinvads.cdc.gov/vads/ViewValueSetConcept.action?id=C224B172-4A08-4613-B2EF-5476337A6705

Carcinoma - WikipediaCarcinoma - Wikipedia

8390-8420) Adnexal and Skin appendage Neoplasms. *(8430-8439) Mucoepidermoid Neoplasms. *(8440-8490) Cystic, Mucinous and ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ... Carcinoma is a category of types of cancer that develop from epithelial cells.[1] Specifically, a carcinoma is a cancer that ...
more infohttps://en.wikipedia.org/wiki/Carcinomas

Acinic cell carcinomaAcinic cell carcinoma

ICD-9 142.0 ICD-O: M8550/3 Acinic cell carcinoma is a tumor most ... Adnexal And Skin appendage (8390-8429). sweat gland ( ... Acinic cell carcinoma Acinic cell carcinomaClassification & external resources ICD-10 C07. ... Papilloma/carcinoma (8010-8139). Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - ... Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor ...
more infohttps://www.bionity.com/en/encyclopedia/Acinic_cell_carcinoma.html

The Mammary Bud as a Skin Appendage: Unique and Shared Aspects of Development | SpringerLinkThe Mammary Bud as a Skin Appendage: Unique and Shared Aspects of Development | SpringerLink

Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early ... Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85(6):841-51.PubMed ... Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early ... Homeobox genes Msx-1 and Msx-2 are associated with induction and growth of skin appendages. J Invest Dermatol 1995;104(5):711-9 ...
more infohttps://link.springer.com/article/10.1007%2Fs10911-006-9029-x

Skin Appendage Tumors Seem on the Rise in U.S. | Health24Skin Appendage Tumors Seem on the Rise in U.S. | Health24

Cutaneous appendageal carcinoma incidence rates are increasing in the United States, especially for sebaceous carcinoma, ... Skin Appendage Tumors Seem on the Rise in U.S.. Cancer of sweat glands most common, but cases of eyelid cancer also up, study ... MONDAY, June 21 (HealthDay News) -- Tumors of skin appendages, such as sweat glands, mammary glands, hair and nails, appear to ... The most common type was cancer of the sweat glands (apocrine-eccrine carcinoma). ...
more infohttp://www.health24.com/Medical/Cancer/News/Skin-Appendage-Tumors-Seem-on-the-Rise-in-US-20120721

PPT - Diseases of the Skin Appendages PowerPoint Presentation - ID:76728PPT - Diseases of the Skin Appendages PowerPoint Presentation - ID:76728

Diseases of the Skin Appendages. Adam Wray, D.O. September 13, 2005. Non-scarring alopecias. Alopecia areata. Characterized by ... Skin Theory -. skin theory skin disorders skin care. dermatology. the study of skin, its structures, function, diseases and ... Chapter 6: Skin and Its Appendages -. introduction. skin (integument) is the bodys largest organ approximately 1.6 to 1.9 m 2 ... COMMON SKIN INFECTIONS -. presented by shalina shaik pgy 2 emory family medicine. skin infections. the skin always has some ...
more infohttps://www.slideserve.com/DoraAna/diseases-of-the-skin-appendages

Most recent papers with the keyword nose reconstruction | Read by QxMDMost recent papers with the keyword nose reconstruction | Read by QxMD

... squamous cell carcinoma, cancer of skin appendages, and precancerous lesions and 194 lesions were included... ... 180 patients who were surgically treated with diagnoses of skin basal cell carcinoma, ... Surgery of the nose to remove skin cancer often requires the use of local flaps. We present a defect after the extirpation of a ... This procedure comprised raising a flap of skin from the upper arm to reconstruct the nose. The arm was kept in place, with the ...
more infohttps://www.readbyqxmd.com/keyword/34658

Brovana (Arformoterol Tartrate Inhalation Solution): Side Effects, Interactions, Warning, Dosage & UsesBrovana (Arformoterol Tartrate Inhalation Solution): Side Effects, Interactions, Warning, Dosage & Uses

Respiratory: carcinoma of the lung, respiratory disorder, voice alteration. Skin and Appendages : dry skin, herpes simplex, ... arformoterol caused a statistically significant increase in the incidence of thyroid gland c-cell adenoma and carcinoma in ...
more infohttps://www.rxlist.com/brovana-drug.htm

International Classification of Diseases for Oncology - WikipediaInternational Classification of Diseases for Oncology - Wikipedia

Skin appendage tumor, benign Adnexal tumor, benign M8390/3 Skin appendage carcinoma (C44._) Adnexal carcinoma M8391/0 ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... Renal cell carcinoma, spindle cell M8319/3 collecting duct carcinoma (C64.9) Bellini duct carcinoma Renal carcinoma, collecting ... NOS Condylomatous carcinoma Verrucous squamous cell carcinoma Verrucous epidermoid carcinoma Warty carcinoma M8052/0 Squamous ...
more infohttps://en.wikipedia.org/wiki/International_Classification_of_Diseases_for_Oncology

DailyMed - BICALUTAMIDE tablet, film coatedDailyMed - BICALUTAMIDE tablet, film coated

Skin and Appendages: Dry Skin; Alopecia; Pruritus; Herpes Zoster; Skin Carcinoma; Skin Disorder ... Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or ... Yellowing of the skin and eyes (jaundice), dark urine, right upper stomach pain, nausea, vomiting, tiredness, loss of appetite ... Symptoms of an allergic reaction include: itching of the skin, hives (raised bumps), swelling of the face, lips, tongue, throat ...
more infohttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c267f783-1d39-4f27-83ed-8288577bf66d

DailyMed - BICALUTAMIDE - bicalutamide tablet, film coatedDailyMed - BICALUTAMIDE - bicalutamide tablet, film coated

Skin and Appendages: Dry Skin; Alopecia; Pruritus; Herpes Zoster; Skin Carcinoma; Skin Disorder ... Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or ... Yellowing of the skin and eyes (jaundice), dark urine, right upper stomach pain, nausea, vomiting, tiredness, loss of appetite ... An allergic reaction. Symptoms of an allergic reaction include: itching of the skin, hives (raised bumps), swelling of the face ...
more infohttps://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8b533fe4-287f-482c-b530-d9a5bf2ce40c

Yi LU, et al. DNA-Gold Nanoparticle GeometryYi LU, et al. DNA-Gold Nanoparticle Geometry

... tumors of the skin (e.g., squamous cell carcinoma, basal cell carcinoma, malignant melanoma, skin appendage tumors, Kaposi ... carcinoma, bladder carcinoma (including, for instance, transitional cell carcinoma, adenocarcinoma, and squamous carcinoma), ... sarcoma, cutaneous lymphoma, skin adnexal tumors and various types of sarcomas and Merkel cell carcinoma), esophageal carcinoma ... non-small cell carcinoma, large cell carcinoma, squamous carcinoma, and adenocarcinoma), mesothelioma of the lung, colorectal ...
more infohttp://rexresearch.com/lu-dnau/lu-dnau.htm

Intraductal carcinoma arising in intraductal papilloma
in an axillary lymph node: review of the literature and proposed...Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed...

Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed ... 1-5) In the axilla, benign heterotopic glands are hypothesized to arise from breast or skin appendage glands by theories of ... Intraductal carcinoma arising in intraductal papilloma in an axillary lymph node: review of the literature and proposed ... Thyroid carcinoma developing in a cervical lymph node. Ann Intern Med. 1979;90:205-206.. (9.) Adkins GF, Hinckley DM. Primary ...
more infohttp://www.biomedsearch.com/article/Intraductal-carcinoma-arising-in-intraductal/230246894.html

Carcinoma - WikipediaCarcinoma - Wikipedia

Adenoid cystic carcinoma (M8312/3) Renal cell carcinoma (M8312/3) Grawitz tumor (8390-8420) Adnexal and Skin appendage ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ... Carcinoma is a type of cancer that develops from epithelial cells. Specifically, a carcinoma is a cancer that begins in a ... A history of cigarette smoking is the most common cause of large cell carcinoma. The term carcinoma has also come to encompass ...
more infohttps://en.wikipedia.org/wiki/Carcinoma

Prevacid I.v. For Injection Information from Drugs.comPrevacid I.v. For Injection Information from Drugs.com

... dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, rash, skin carcinoma, skin disorder, ... Skin and Appendages - severe dermatologic reactions including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal ... Body as a Whole - abdomen enlarged, allergic reaction, asthenia, back pain, candidiasis, carcinoma, chest pain (not otherwise ... It also produced an increased incidence of liver tumors (hepatocellular adenoma plus carcinoma). The tumor incidences in male ...
more infohttps://www.drugs.com/drp/prevacid-i-v-for-injection.html

NAC: CHAPTER 457 - CANCERNAC: CHAPTER 457 - CANCER

7. Adnexal and skin appendage neoplasms:. Skin appendage carcinoma. Adnexal carcinoma. Sweat gland adenocarcinoma ... Carcinoma in situ of the cervix and noninvasive basal and squamous cell carcinomas of the skin are not required to be reported ...
more infohttps://www.leg.state.nv.us/NAC/NAC-457.html
  • Bicalutamide Tablets, USP 50 mg are an androgen receptor inhibitor indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D 2 metastatic carcinoma of the prostate. (nih.gov)
  • There was no evidence of invasive or metastatic carcinoma. (biomedsearch.com)
  • Here, we review what is known of the molecular and cellular mechanisms controlling early steps in the development of these organs, attempt to unravel both common themes and unique aspects that can begin to explain the diversity of appendage formation, and discuss human genetic diseases that affect appendage morphogenesis. (springer.com)
  • Mammary-like glands (MLGs) are present in the skin of the anogenital region of males as well as females. (biomedcentral.com)
  • Cutaneous appendageal carcinoma incidence rates are increasing in the United States, especially for sebaceous carcinoma, perhaps related to improved recognition and classification, but factors such as UV exposure and immunosuppression may also play a role,' Patrick W. Blake and colleagues said in a news release from the publisher. (health24.com)
  • Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal , mesodermal or ectodermal germ layer during embryogenesis . (wikipedia.org)
  • Small-cell lung carcinoma can occur in combination with a wide variety of other histological variants of lung cancer , [ 9 ] including extremely complex malignant tissue admixtures. (omicsgroup.org)
  • adeno = gland ) Refers to a carcinoma featuring microscopic glandular-related tissue cytology, tissue architecture, and/or gland-related molecular products, e.g., mucin . (wikipedia.org)