Carcinoma, Skin Appendage
Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Members of the TNF receptor family that are specific for ECTODYSPLASIN. At least two subtypes of the ectodysplasin receptor exist, each being specific for a ectodysplasin isoform. Signaling through ectodysplasin receptors plays an essential role in the normal ectodermal development. Genetic defects that result in loss of ectodysplasin receptor function results ECTODERMAL DYSPLASIA.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
Neoplasms, Adnexal and Skin Appendage
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
A group of hereditary disorders involving tissues and structures derived from the embryonic ectoderm. They are characterized by the presence of abnormalities at birth and involvement of both the epidermis and skin appendages. They are generally nonprogressive and diffuse. Various forms exist, including anhidrotic and hidrotic dysplasias, FOCAL DERMAL HYPOPLASIA, and aplasia cutis congenita.
Hoof and Claw
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Tumors or cancer of the SKIN.
Carcinoma in Situ
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.
Carcinoma, Basal Cell
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Carcinoma, Ductal, Breast
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
Skin Physiological Phenomena
Carcinoma, Transitional Cell
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Carcinoma, Intraductal, Noninfiltrating
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma, Adenoid Cystic
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Carcinoma, Small Cell
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Uptake of substances through the SKIN.
Gene Expression Regulation, Neoplastic
Coloration of the skin.
Tumor Cells, Cultured
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Carcinoma, Merkel Cell
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
Carcinoma, Signet Ring Cell
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
Neoplasm Recurrence, Local
Spermatic Cord Torsion
The twisting of the SPERMATIC CORD due to an anatomical abnormality that left the TESTIS mobile and dangling in the SCROTUM. The initial effect of testicular torsion is obstruction of venous return. Depending on the duration and degree of cord rotation, testicular symptoms range from EDEMA to interrupted arterial flow and testicular pain. If blood flow to testis is absent for 4 to 6 h, SPERMATOGENESIS may be permanently lost.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Reverse Transcriptase Polymerase Chain Reaction
Carcinoma, Large Cell
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Neoplasms, Multiple Primary
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any of numerous burrowing mammals found in temperate regions and having minute eyes often covered with skin.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
Gene Expression Regulation, Developmental
Congenital structural abnormalities of the skin.
In Situ Hybridization
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumor Suppressor Protein p53
Embryonal Carcinoma Stem Cells
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Carcinoma, Papillary, Follicular
Carcinoma, Non-Small-Cell Lung
Tomography, X-Ray Computed
Adenocarcinoma, Clear Cell
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The family Gryllidae consists of the common house cricket, Acheta domesticus, which is used in neurological and physiological studies. Other genera include Gryllotalpa (mole cricket); Gryllus (field cricket); and Oecanthus (tree cricket).
Combined Modality Therapy
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Carcinoma, Lewis Lung
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages. (1/25)Familial cylindromatosis (turban tumor syndrome; Brooke-Spiegler syndrome) (OMIM numbers 123850, 132700, 313100, and 605041) is a rare autosomal dominantly inherited tumor syndrome. The disorder can present with cutaneous adnexal tumors such as cylindromas, trichoepitheliomas, and spiradenomas, and tumors preferably develop in hairy areas of the body such as head and neck. In affected families, mutations have been demonstrated in the CYLD gene located on chromosome 16q12-13 and reveal the characteristic attributes of a tumor suppressor. Here, we studied familial cylindromatosis in a multigeneration family of German origin. Clinically, some individuals only revealed discrete small skin-colored tumors localized in the nasolabial region whereas one family member showed expansion of multiple big tumors on the trunk and in a turban-like fashion on the scalp. Histologically, cylindromas as well as epithelioma adenoides cysticum were found. We detected a frameshift mutation in the CYLD gene, designated 2253delG, underlying the disorder and were able to show that a single mutation can result in distinct clinical and histologic expression in familial cylindromatosis. The reasons for different expression patterns of the same genetic defect in this disease remain elusive, however. Identification of mutations in the CYLD gene enable us to rapidly confirm putative diagnoses on the genetic level and to provide affected families with genetic counseling. (+info)
Piloleiomyoma--a report of five cases. (2/25)Piloleiomyomas are uncommon smooth muscle neoplasms of the skin with a few reproted cases in Indian literature (1,2,3,4,5). They are often misdiagnosed clinically. A correct biopsy report is important because patients may have to be managed medically since surgery is associated with a high rate of recurrence. The classical histologic findings, and Masson's stain to confirm the smooth muscle origin aids in the correct diagnosis. (+info)
Squamous cell carcinoma in situ arising in mature cystic teratoma. (3/25)Mature cystic teratomas of ovary are common tumors. A few may exhibit malignant degeneration, most of these being invasive squamous cell carcinoma. We report a rare case of pure squamous cell carcinoma in situ in benign cystic teratoma. (+info)
A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome. (4/25)Brooke-Spiegler syndrome (BSS, familial cylindromatosis or turban tumor syndrome) is an inherited disease characterized by neoplasms of the skin appendages such as cylindroma, trichoepithelioma, and spiradenoma. The disease has been mapped to 16q12-13, and mutations in the CYLD gene have been identified in families with this disorder. Of interest, multiple familial trichoepithelioma (MFT) has been described as a distinct disorder characterized by the familial occurrence of trichoepitheliomas. MFT has been mapped to 9p21; however, to date a candidate gene has not been identified. In this report, we describe a four-generation family with BSS presenting predominantly with trichoepitheliomas (resembling MFT phenotype). We identified a novel missense mutation in the CYLD gene, designated E474G, in the affected individuals of this family. Our findings exemplify clinical heterogeneity within BSS and extend the body of evidence that mutations in CYLD are implicated in this disease. Although not conclusive, these findings suggest that BSS and MFT may represent a single entity. (+info)
Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. (5/25)Brooke-Spiegler syndrome (BSS), familial cylindromatosis (FC), and multiple familial trichoepithelioma (MFT), originally described as distinct entities, share overlapping clinical findings. Patients with BSS are predisposed to multiple skin appendage tumors such as cylindroma, trichoepithelioma, and spiradenoma. FC, however, is characterized by cylindromas and MFT by trichoepitheliomas as the only tumor type. These disorders have recently been associated with mutations in the CYLD gene. In this report, we describe three families with BSS, one with FC, and two with MFT phenotypes associated with novel and recurrent mutations in CYLD. We provide evidence that these disorders represent phenotypic variation of a single entity and lack genotype-phenotype correlation. (+info)
Sex steroid hormone receptors in human skin appendage and its neoplasms. (6/25)Sex steroids have been postulated to influence pathophysiology of human skin through various skin appendages. The presence of sex steroid receptors has been also reported in adnexal tumors but its details still remained unknown. Therefore, in this study, we immunolocalized sex steroid receptor protein (estrogen receptor (ER)alpha, ERbeta, progesterone receptor (PR)A, PRB and androgen receptor (AR)) in 23 cases of non-pathological skin (male: 10, female: 13) and in 50 cases of skin adnexal tumors (male 24, female 26; 38 benign and 12 malignant). ERalpha immunoreactivity was detected exclusively in basal cells of sebaceous glands of non-pathological skin. AR and PRB immunoreactivity was detected in both differentiated and basal cells of sebaceous gland. AR and ERbeta immunoreactivity was also detected in sebaceous and eccrine sweat glands but not in outer root sheath of hair follicles. In sebaceous gland neoplasms, the number of ERalpha positive cases was significantly lower in skin appendage neoplasms than non-pathological skin. ERbeta immunoreactivity was not detected in any of sebaceous gland neoplasms examined. There were no significant differences in PRA, PRB and AR immunoreactivity between non-pathological sebaceous gland and its neoplasm. In sweat gland neoplasms, the number of AR positive cases was significantly lower in benign neoplasms than their non-pathological counterpart. Therefore sex steroids are considered to play important roles in regulation of non-pathological skin appendage function and pathogenesis and/or development of its neoplasm. In addition, the status of the great majority of sex steroid hormone receptors was maintained throughout the process of neoplastic transformation of skin appendages, except for AR and ERalpha in sweat and sebaceous gland neoplasms. (+info)
Genetics of skin appendage neoplasms and related syndromes. (7/25)In the past decade the molecular basis of many inherited syndromes has been unravelled. This article reviews the clinical and genetic aspects of inherited syndromes that are characterised by skin appendage neoplasms, including Cowden syndrome, Birt-Hogg-Dube syndrome, naevoid basal cell carcinoma syndrome, generalised basaloid follicular hamartoma syndrome, Bazex syndrome, Brooke-Spiegler syndrome, familial cylindromatosis, multiple familial trichoepitheliomas, and Muir-Torre syndrome. (+info)
Canine cutaneous clear cell adnexal carcinoma: histopathology, immunohistochemistry, and biologic behavior of 26 cases. (8/25)Thirty tumors including 27 distinctive cutaneous neoplasms and 3 metastatic tumors from 26 dogs were collected from diagnostic submissions to 3 laboratories. Characteristic histopathologic features included location in the subcutis or dermis (or both); lobular, nodular, and nest-like architecture; and a component of epithelioid cells with clear cytoplasm. Additional features present in most cases included follicular dermal papilla-like structures, low mitotic index, nuclear pleomorphism, necrosis, and mineralization. Cytoplasmic periodic acid Schiff-positivity, which was abolished by pretreatment with diastase, indicated the presence of glycogen in all cases. The oil red O stain did not demonstrate cytoplasmic lipid. Melanin granules, accentuated by the Fontana-Masson method, were observed infrequently. A sparsely cellular mucinous stroma and stromal cartilaginous differentiation were uncommon. By immunohistochemistry, neoplastic cells stained positively for cytokeratin (29 of 29), vimentin (28 of 28), S-100 protein (24 of 29), and melan A (8 of 12); results were negative for smooth muscle actin and calponin in all cases. Clinical follow-up information was obtained on all 26 dogs. One tumor recurred, 1 metastasized to a regional lymph node, and 1 metastasized to regional lymph nodes twice. In another case, possible pulmonary metastasis was noted radiographically. The findings are consistent with a poorly differentiated, low-grade, adnexal carcinoma of the skin. Similar canine cutaneous neoplasms have been reported as "clear-cell hidradenocarcinoma" and "follicular stem cell carcinoma." The authors propose the designation "cutaneous clear cell adnexal carcinoma." (+info)
Multiple familial trichoepithelioma - Wikipedia
Multiple familial trichoepithelioma (also known as Brooke-Spiegler syndrome and epithelioma adenoides cysticum) is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face. The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene. Types include: Brooke-Spiegler syndrome is a condition where multiple skin tumors develop from skin structures. Tumors commonly occurring in this syndrome include spiradenomas, trichoepitheliomas, and cylindromas. The tumors are generally benign, but may become malignant. Affected individuals are also at increased risk of developing tumors in tissues other than skin - particularly benign or malignant tumors of the salivary glands. Tumours in Brooke-Spiegler typically appear in early adulthood ...
Microcystic adnexal carcinoma
Microcystic adnexal carcinoma is a rare type of cancer that usually develops in areas of the body where sweat is produced (sweat glands). The largest of these sweat-producing sites and also the most common location where microcystic adnexal carcinoma develops is the central face. The cancer forms when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Microcystic adnexal carcinoma may also occur in the general head and neck regions. Some of these cancerous cells can break off and spread (metastasize) to other parts of the body and grow there.. Microcystic adnexal carcinoma most commonly occurs in adults between the ages of 40 and 60, though it can appear in all age groups. Factors that may increase the risk of developing microcystic adnexal carcinoma include excess exposure to sunlight, sunburn, and a family history of skin cancer. The most common symptoms of microcystic adnexal carcinoma include redness, inflammation, and irritation of ...
Multiple familial trichoepithelioma - Genetics Home Reference
Multiple familial trichoepithelioma can be caused by mutations in the CYLD gene. This gene provides instructions for making a protein that helps regulate nuclear factor-kappa-B. Nuclear factor-kappa-B is a group of related proteins that help protect cells from self-destruction (apoptosis) in response to certain signals. In regulating the action of nuclear factor-kappa-B, the CYLD protein allows cells to respond properly to signals to self-destruct when appropriate, such as when the cells become abnormal. By this mechanism, the CYLD protein acts as a tumor suppressor, which means that it helps prevent cells from growing and dividing too fast or in an uncontrolled way.. People with CYLD-related multiple familial trichoepithelioma are born with a mutation in one of the two copies of the CYLD gene in each cell. This mutation prevents the cell from making functional CYLD protein from the altered copy of the gene. However, enough protein is usually produced from the other, normal copy of the gene to ...
Microcystic adnexal carcinoma: an unpredictable aggressive neoplasm.<...
TY - JOUR. T1 - Microcystic adnexal carcinoma. T2 - an unpredictable aggressive neoplasm.. AU - Hamm, J. C.. AU - Argenta, L. C.. AU - Swanson, N. A.. PY - 1987/8. Y1 - 1987/8. N2 - Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm that has been recently recognized as a distinct entity. Typically it appears as a papular, flesh-colored mass on the face of women patients. Because of its benign appearance, it is often present for months or years before diagnosis. Histologically, there is a paucity of mitotic figures and other criteria usually associated with aggressive lesions. In this article we discuss 3 cases of microcystic adnexal carcinoma, each presenting as a small, localized lesion but all requiring extensive surgical extirpation with margin control using the Mohs tissue resection technique.. AB - Microcystic adnexal carcinoma is a rare, locally aggressive cutaneous neoplasm that has been recently recognized as a distinct entity. Typically it appears as a ...
Brooke-Spiegler syndrome - Dermatology Advisor
Blake , PW, Toro , JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat. vol. 30. 2009. pp. 1025-36. (A comprehensive review about the clinical features, molecular genetics, and the animal models of Brooke-Spiegler syndrome.). Layegh , P, Sharifi-Sistani , N, Abadian , M, Moghiman , T. Brooke-Spiegler syndrome. Indian J Dermatol Venereol Leprol. vol. 74. 2008. pp. 632-4. (A case report describing a patient diagnosed as Brooke-Spiegler syndrome.). Kazakov , DV, Zelger , B, Rütten , A, Vazmitel , M, Spagnolo , DV, Kacerovska , D. Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol. vol. 33. 2009. pp. 705-19. (An article describing a series of 24 malignant neoplasms arising in preexisting benign spiradenoma ...
RePub, Erasmus University Repository: Multiple familial trichoepithelioma and familial cylindroma: One cause!
Oranje, A.P, Halley, D.J.J, den Hollander, J.C, Teepe, R.G.J, van de Graaf, R, van den Ouweland, A.M.W, & Wagner, A. (2008). Multiple familial trichoepithelioma and familial cylindroma: One cause!. Journal of the European Academy of Dermatology and Venereology, 22(11), 1395-1396. doi:10.1111/j.1468-3083.2008.02648. ...
microcystic adnexal carcinoma histopathology - Loma Linda Dermatopathology
Dermatopathology reference describes microcystic adnexal carcinoma histopathology including histologic features and provides links to additional medical references.
Familial Cylindromatosis (Turban Tumor Syndrome): Symptoms, Diagnosis and Treatment - Symptoma
Familial Cylindromatosis (Turban Tumor Syndrome): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
PPT - Brooke-Spiegler Syndrome PowerPoint Presentation - ID:156085
Brooke-Spiegler Syndrome. Quyn Sherrod, MD; Miguel Gutierrez, MD; Keith Carlson, MD UCLA/WLA VA Division of Dermatology David Geffen School of Medicine Los Angeles, California. History. 39 year-old, healthy, Caucasian male Multiple lesions on face and scalp beginning at 10 years old...
A Case of Microcystic Adnexal Carcinoma
COPYRIGHT (C) 2016 KISTI. ALL RIGHTS RESERVED.. 대전광역시 유성구 대학로 245 한국과학기술정보연구원TEL : 042.869.1234 서울시 동대문구 회기로 66NDSL고객센터 : 080.969.4114E-mail : [email protected] ...
CYLD Peptide | Abbiotec
CYLD is a negative regulator of TRAF2 and NF-kappa B signaling pathway. CYLD has a deubiquitinating activity that is directed towards non-Lys48-linked polyubiquitin chains. Defects in CYLD are the cause of familial cylindromatosis, a highly tumor type-specific disorder ...
CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin | SFB 829
CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating enzyme that was shown to regulate cell proliferation, cell survival and inflammatory responses, mainly through inhibiting NF-kappaB signalling. Here we show that CYLD controls cell growth and division at the G(1)/S-phase as well as cytokinesis by associating with alpha-tubulin and microtubules through its CAP-Gly domains. Translocation of activated CYLD to the perinuclear region of the cell is achieved by an inhibitory interaction of CYLD with histone deacetylase-6 (HDAC6) leading to an increase in the levels of acetylated alpha-tubulin around the nucleus. This facilitates the interaction of CYLD with Bcl-3, leading to a significant delay in the G(1)-to-S-phase transition. Finally, CYLD also interacts with HDAC6 in the midbody where it regulates the rate of cytokinesis in a deubiquitinase-independent manner. Altogether these results identify a ...
Brooke-Fordyce trichoepithelioma | definition of Brooke-Fordyce trichoepithelioma by Medical dictionary
Looking for online definition of Brooke-Fordyce trichoepithelioma in the Medical Dictionary? Brooke-Fordyce trichoepithelioma explanation free. What is Brooke-Fordyce trichoepithelioma? Meaning of Brooke-Fordyce trichoepithelioma medical term. What does Brooke-Fordyce trichoepithelioma mean?
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB | Nature
Protein modification by the conjugation of ubiquitin moieties-ubiquitination-plays a major part in many biological processes, including cell cycle and apoptosis1. The enzymes that mediate ubiquitin-conjugation have been well-studied, but much less is known about the ubiquitin-specific proteases that mediate de-ubiquitination of cellular substrates2,3. To study this gene family, we designed a collection of RNA interference vectors to suppress 50 human de-ubiquitinating enzymes, and used these vectors to identify de-ubiquitinating enzymes in cancer-relevant pathways. We report here that inhibition of one of these enzymes, the familial cylindromatosis tumour suppressor gene (CYLD)4, having no known function, enhances activation of the transcription factor NF-κB. We show that CYLD binds to the NEMO (also known as IKKγ) component of the IκB kinase (IKK) complex, and appears to regulate its activity through de-ubiquitination of TRAF2, as TRAF2 ubiquitination can be modulated by CYLD. Inhibition of CYLD
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. - NDM Research...
The mechanism by which Wnt receptors transduce signals to activate downstream beta-catenin-mediated target gene transcription remains incompletely understood but involves Frizzled (Fz) receptor-mediated plasma membrane recruitment and activation of the cytoplasmic effector Dishevelled (Dvl). Here, we identify the deubiquitinating enzyme CYLD, the familial cylindromatosis tumor suppressor gene, as a negative regulator of proximal events in Wnt/beta-catenin signaling. Depletion of CYLD from cultured cells markedly enhances Wnt-induced accumulation of beta-catenin and target gene activation. Moreover, we demonstrate hyperactive Wnt signaling in human cylindroma skin tumors that arise from mutations in CYLD. At the molecular level, CYLD interacts with and regulates K63-linked ubiquitination of Dvl. Enhanced ubiquitination of the polymerization-prone DIX domain in CYLD-deficient cells positively links to the signaling activity of Dvl. Together, our results argue that loss of CYLD instigates tumor growth in
The Role of Bcl-2, CD10 and CD34 Expression in Differentiation between Basal Cell Carcinoma and Trichoepithelioma - pdf...
The Role of Bcl-2, CD10 and CD34 Expression in Differentiation between Basal Cell Carcinoma and Trichoepithelioma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Distinct mechanisms underlie pattern formation in the skin and skin appendages - The Mathematical Institute, University of...
Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of patterns. Here, we first introduce the basics of pattern formation and their possible biological basis. We then discuss different categories of skin patterns and their potential underlying molecular mechanisms. Some patterns, such as the lines of Blaschko and Naevus, are based on cell lineage and genetic mosaicism. Other patterns, such as regionally specific skin appendages, can be set by distinct combinatorial molecular codes, which in turn may be set by morphogenetic gradients. There are also some patterns, such as the arrangement of hair follicles (hair whorls) and fingerprints, which involve genetics as well as stochastic epigenetic events based on physiochemical principles. Many appendage primordia are laid out in developmental waves. In the adult, some patterns, such as those involving cycling hair ...
The Mammary Bud as a Skin Appendage: Unique and Shared Aspects of Development | SpringerLink
Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early stages in embryonic mammary development strikingly resemble analogous steps in
2020 ICD-10-CM Codes L60-L75: Disorders of skin appendages
A type 1 excludes note is a pure excludes. It means not coded here. A type 1 excludes note indicates that the code excluded should never be used at the same time as L60-L75. A type 1 excludes note is for used for when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition ...
SOON CHUN HYANG UNIVERSITY HOSPITAL BUCHEON
Dermatology is a specialty that deals with all illnesses that occur in any part of the skin, spinous mucosal membrane, finger and toe nails, hair and other skin appendages. The Department of Dermatology treats and provides assistance to patients through comprehensive research in various top-notch fields such as immunology, genetics and molecular biology as well as basic medicine. ...
Desmoplastic trichoepithelioma | definition of desmoplastic trichoepithelioma by Medical dictionary
Looking for online definition of desmoplastic trichoepithelioma in the Medical Dictionary? desmoplastic trichoepithelioma explanation free. What is desmoplastic trichoepithelioma? Meaning of desmoplastic trichoepithelioma medical term. What does desmoplastic trichoepithelioma mean?
Infundibular (Follicular) and Infundibulocystic Squamous Cel... : The American Journal of Dermatopathology
To the Editor:. Misago et al1 have recently published 6 cases of infundibular (follicular) and 2 examples of infundibulocystic squamous cell carcinoma and have redefined the original criteria for both follicular squamous cell carcinoma and infundibulocystic squamous cell carcinoma.2,3 They propose that the term infundibular squamous cell carcinoma was synonymous with follicular squamous cell carcinoma, and infundibulocystic carcinoma was a distinctive tumor sharing features with microcystic adnexal carcinoma.. In the initial description of 16 examples of follicular squamous cell carcinoma by Diaz-Cascajo et al,2 these squamous cell carcinomas arose in follicles and formed nodular tumors that replaced the follicles but did not demonstrate follicular differentiation even when the tumor infiltrated the surrounding tissue. From a clinical perspective, follicular squamous cell carcinomas in the original study were described as dermal nodules that did not resemble keratoacanthoma and were diagnosed as ...
Dermatology Specialists of St. Louis - Precancers & Skin Cancers
Less Common Skin Cancers. Merkel Cell Carcinoma is a rare and aggressive form of skin cancer. It arises from Merkel cells in the lower part of the epidermis. Merkel cells are similar to nerve cells and give the skin touch sensation. Treatment involves a team approach from physicians with significant experience with the disease.. Atypical Fibroxanthoma is thought to arise from the dermis, which is deeper than the epidermis, the source of most other skin cancers. It classically appears on the face or scalp as a reddish, sometimes glistening plaque (broad, raised area on the skin).. Microcystic Adnexal Carcinoma is thought to be derived from cells that produce the adnexal structures, such as hair follicles and sweat glands in the skin. It classically occurs on the face. It may have a deceivingly benign appearance and may be mistaken for a common melanocytic nevus (mole ...
Most recent papers with the keyword sebaceous carcinoma | Read by QxMD
Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. In this context, sebaceous differentiation in MAC would support the first option. However, there are only 3 cases of MAC with sebaceous differentiation in the literature, and all of them were reported before adipophilin was available, which in the appropriate context (eg, testing clear cells for sebaceous vs eccrine differentiation) is very useful ...
Skin appendage - Wikipedia
Skin appendages (or adnexa) are skin-associated structures that serve a particular function including sensation, contractility, lubrication and heat loss. In humans, some of the more common skin appendages are hairs (sensation, heat loss, filter for breathing, protection), arrector pilli (smooth muscles that pull hairs straight), sebaceous glands (secrete sebum onto hair follicle, which oils the hair), sweat glands (can be sweat secreted with strong odour (apocrine) or with a faint odour (eccrine)) and nails (protection). Skin appendages are derived from the skin, and are usually adjacent to it. Types of Appendages include hair, glands, and nails. Sweat Glands are distributed all over the body except nipples and outer genitals. Although the nipples do have the mammary glands, these are known as modified sweat glands. Sebaceous Glands are typically found in the opening shaft of hair. They are not on the palms of the hands or the soles of the feet. These glands secret an antibacterial moisture ...
Skin type spiradenoma of the parotid gland with malignant transformation: report of a case with analysis of the CYLD gene. -...
Hum Pathol. 2009 Oct;40(10):1499-503. doi: 10.1016/j.humpath.2009.02.015. Epub 2009 May 19. Case Reports; Research Support, Non-U.S. Govt
GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma - Lunds universitet
CYLD is a deubiquitination enzyme that regulates different cellular processes, such as cell proliferation and cell survival. Mutation and loss of heterozygosity of the CYLD gene causes development of cylindromatosis, a benign tumour originating from the skin. Our study shows that CYLD expression is dramatically downregulated in basal cell carcinoma (BCC), the most common cancer in humans. Reduced CYLD expression in basal cell carcinoma was mediated by GLI1-dependent activation of the transcriptional repressor Snail. Inhibition of GLI1 restored the CYLD expression-mediated Snail signaling pathway, and caused a significant delay in the G1 to S phase transition, as well as proliferation. Our data suggest that GLI1-mediated suppression of CYLD has a significant role in basal cell carcinoma progression. Oncogene (2011) 30, 4523-4530; doi: 10.1038/onc.2011.163; published online 16 May ...
Browse by Author - The Mathematical Institute, University of Oxford, Eprints Archive
Lin, C.M and Jiang, T.X. and Baker, Ruth E. and Maini, P. K. and Widelitz, R. B. and Chunong, C.M. (2009) Spots & stripes: pleomorphic patterning of stem cells via p-ERK-depenendent cell chemotaxis shown by feather morphogenesis & mathematical simulation. Developmental Biology, 334 (2). pp. 369-382. Lin, C. and Jiang, T. and Baker, Ruth E. and Maini, P. K. and Hughes, M. and Widelitz, R. B. and Chuong, C. (2008) Periodic patterning stem cells and induction of skin appendages: p-ERK-dependent mesenchymal condensation is coupled with Turing mechanism to convert stripes to spots. Journal of Investigative Dermatology, 128 (S1). S156. Widelitz, R. B. and Baker, Ruth E. and Plikus, M. V. and Lin, C. and Maini, P. K. and Paus, R. and Chuong, C. M. (2006) Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Research (Part C),, 78 (3). pp. 280-291. ...
Allergy bumps in eyes - Things You Didnt Know
Allergy bumps in eyes - I have little white bumps under my eyes, have allergies, I take medicine but what can I do to make the white bumps go away? White bumps. It is unclear from your description whether these are not normal skin appendages. You can try warm compresses for 10 minutes at a time. Otherwise best seen in person.
Histomorphological spectrum of skin adnexal tumours : a retrospective study in a tertiary care centre | Annals of...
Background: Skin Adnexal Tumours (SATs ) are large and divergent group of tumours which are classified based on their appendageal differentiation into eccrine,follicular,sebaceous and apocrine.They pose daunting diagnostic challenges to both clinicians and pathologists alike.This study aims to evaluate the histopathological charecterestics of skin adnexal neoplasms and correlate with their clinical profile.Methods : This is a retrospective study of skin adnexal tumours (28 cases) diagnosed on histopathological examination over a period of two years .( January 2014 to December 2015 ).Results: Skin adnexal tumours are uncommon lesions with an incidence of 0.27%.These tumours were common in the 51 to 60 age group and showed a female preponderance. Head and neck region particularly the scalp was commonly involved. Benign tumours were more common (78.6% ) than the malignant ones (21.4%). .Sweat gland tumours constituted the largest group (61%) followed by hair follicle tumours (21%)and sebaceous ...
ISRCTN - ISRCTN75715723: Tropomyosin receptor kinase antagonism in cylindromatosis
This study aims to evaluate a new ointment to treat an inherited skin tumour condition called cylindromatosis. Patients from families with this condition carry an error in their DNA (CYLD mutation) that results in the development of multiple skin tumours on the face, scalp and trunk. These tumours are disfiguring, can be painful, and may ulcerate and bleed. Surgery is the only available treatment, and up to 1 in 4 patients with this condition undergo removal of their entire scalp to manage this condition. We have recently discovered an abnormal signal in the tumour cells called TRK. This signal is recognised to give tumour cells the ability to survive, and in laboratory tests blocking it with drugs called TRK inhibitors results in the tumour cells dying. We propose a study of an ointment form of TRK inhibitor as a means to reduce tumour growth in these patients. We have partnered with a drug company (Creabilis) who have already produced this ointment (called CT327) for trials in skin conditions. ...
Drosophila CYLD protein Summary Report | CureHunter
Drosophila CYLD protein: ortholog of the human cylindromatosis tumor suppressor protein; involved in a broad range of functions associated with fat homeostasis and host defence; RefSeq NM_164909.1; NP_723554.1
benign neoplasm of scalp 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
We describe the anatomy of the scalp, epidemiology of scalp tumors, theories of field cancerization and field therapy, photodynamic therapy, excisional surgical techniques and reconstruction, lymphoscintigraphy, chemoprevention, as well as details relating to atypical fibroxanthoma, Brooke-Spiegler syndrome, nevus sebaceus, cutaneous lymphoma, and metastatic disease ...
Abstract 595: Anti-inflammatory and Anti-proliferative Action of Cylindromatosis (CYLD) in Atherosclerosis as a...
Growing evidence in clinical studies suggests that ubiquitin systems are greatly related to the progression of atherosclerosis, particularly in relation to inflammation and cell proliferation. However, there were few reports referred to molecular mechanisms of vascular remodeling related to ubiquitin systems. NF-κB is an important transcriptional factor which plays central roles in pathogenesis of atherosclerosis. Thus, in this study, we focused on CYLD which is a NF-κB-related deubiquitinating enzyme and may be a therapeutic target of tumor in cancer research. From Northern blot and immunohistology, CYLD was endogenously expressed in vascular endothelial cells (EC) and smooth muscle cells (VSMC). Interestingly, the treatment of TNF-α significantly increased CYLD expression in EC and VSMC. CYLD was markedly induced in the neointima of the balloon-injured carotid arteries, and was also present in atherosclerotic lesions from human carotid arteries. Thus, the expression of CYLD could be ...
Ovarian dermoid cyst | Radiology Case | Radiopaedia.org
Ovarian dermoid | Radiology Case | Radiopaedia.org
A mature cystic teratoma of the ovary is called a dermoid cyst. This patient presented with a palpable lump per abdomen. The initial ultrasound scan showed the characteristic sonographic features of an ovarian dermoid cyst. CT abdomen was done la...
The Structure Of The Skin
The skin is the largest organ of the human body, comprising approximately 17% of the body weight. An average adult would have a skin total surface area of around 1.7 square meters. The thickness of the skin varies depending on the site where it resides, ranging from 3mm to 6mm. The skin is the most visible and exposed organ of the body, and hence it is the first line of defense of the body against the harsh environment.. The structure of the skin comprises of three main layers, namely the epidermis, the dermis and the hypodermis. There are also skin appendages that play their own respective roles in the skin. Each make-up of each layer will be described below.. EPIDERMIS. The epidermis is the most dynamic layer among all the layers of the skin. Despite being the thinnest layer, it is actually the most important layer among all. The epidermis consists of 5 sub-layers, that will be listed below:. (a) Stratum germinativum (basal cell layer) - This is the deepest layer composed of keratinocytes. ...
A group of hereditary disorders involving tissues and structures derived from the embryonic ectoderm. They are characterized by the presence of abnormalities at birth and involvement of both the epidermis and skin appendages. They are generally nonprogressive and diffuse. Various forms exist, including anhidrotic and hidrotic dysplasias, FOCAL DERMAL HYPOPLASIA, and aplasia cutis congenita.. ...
A clinicopathologic evaluation of 230 cases of mature cystic teratomas | Nepal Journal of Obstetrics and Gynaecology
Results: MCT comprised 230 (57.6%) out of total 399 cases of ovarian neoplasms. The age range of the patients was 8-74 years. The sizes of the tumors ranged from 2.5-20cm. 12% of the cases were bilateral. Ischemic modifications, presumably due to torsion, were noted in 10% of the cases, mostly in tumors larger than 10cm. None of the tumors of less than 5cm presented with signs of torsion. Malignant transformation was present in seven (3%) cases and was seen especially in older patients and in larger tumors. Squamous cell carcinoma was the most common malignant tumor seen in five cases. One case was a mixed germ cell tumor with components of MCT and yolk sac tumor. ...
Internet Scientific Publications
Discussion Mature cystic teratoma (dermoid cysts), accounts for approximately 25% of all ovarian tumors. They are unilateral in 88% of the cases and present with symptoms related to the mass lesion. They contain a varied mixture of ectodermal, mesodermal and endodermal structures distributed in an organized fashion. The first description of pneumatosis cystoides-like appearance in a mature cystic teratoma was given by Maudsley and Zakhour in a 29 year old primigravida in 1988. Subsequently, two case studies with 13 and 7 cases respectively have been reported. These multicystic structures have been variably called as sieve-like areas and Pneumatosis cystoides-like appearances by various authors. The multicystic structures can occur in any age group, but they are generally found in tumors from older patients. Maudsley and Zakhour suggested these cysts to be gas cysts, as on routine staining and immunohistochemistry neither cyst contents, nor endothelial lining were identified. ...
Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes, Archives of...
Read Melanoma arising in an ovarian cystic teratoma: a systematic review of presentation, treatment, and outcomes, Archives of Gynecology and Obstetrics on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Low genotyping error rates in non-invasively collected samples from roe deer of the Bavarian Forest National Park | SpringerLink
Function of new cancer genes discovered ( Dutch researcher Sebastian Nijman has d...)
Dutch researcher Sebastian Nijman has discovered new genes which are i...Patients with the very rare genetic condition cylindromatosis develop ...People with this disease have a mutated form of the protein CYLD. Nijm...An important implication of this research is that inhibition of the NF...Fanconi anaemia ...,Function,of,new,cancer,genes,discovered,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Pilar Cysts and Trichilemmal Cysts
Austin Texas dermatologists Dr. Miriam Hanson and Dr. Adam Mamelak discuss the appearance, health implications and treatment of a Pilar Cyst in the skin.
TRADING PAINT: Too Many Questions Surround Mayfields Suspension
The D part of Claritin-D stands for decongestant. The decongestant is psuedoephedrine which is available without a prescription, but kept behind the pharmacy counter. It is what the Meth-heads use to cook meth. That is most likely why it flagged positive on the drug test. If he is on any other meds (prescription/non-prescription) the body may not eliminate the meds as quickly/efficiently and it starts to accumulate in the bloodstream. NA$CAR is putting these guys in the position of being fearful of taking ANY meds! What does Jeff Gordon take for his back? What do any of them take for a cold? If someone is taking medication under doctors supervision, with a legal prescription, for legitimate health ailments the substance abuse policy is waived. Brian France wouldnt know a metabolic pathway from a hole in his behind. The NA$CAR doctor is probably nothing more than another yes man. I hope Jeremy is being straight with us. It has exposed a huge flaw in what shouldve been a positive ...
Skin adnexal neoplasms - part 2: An approach to tumours of cutaneous sweat glands | Journal of Clinical Pathology
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Aging | Premature aging and cancer development in transgenic mice lacking functional CYLD - Full Text
Full Text - CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript we report that the tumor suppressor CYLD, similarly to other renowned tumor suppressor genes, protects from premature aging and cancer. We have generated transgenic mice expressing the mutant CYLDC/S protein, lacking its deubiquitinase function, under the control of the keratin 5 promoter, the K5-CYLDC/S mice. These mice express the transgene in different organs, including those considered to be more susceptible to aging, such as skin and thymus. Our results show that K5-CYLDC/S mice exhibit epidermal, hair follicle, and sebaceous gland alterations; and, importantly, they show signs of premature aging from an early age. Typically, 3-month-old K5-CYLDC/S mice exhibit a phenotype characterized by alopecia and kyphosis, and, the histological examination reveals that transgenic mice show signs
cyld displays a dominant genetic linkage to multiple types of cutaneous adnexal tumors that often develop in bulky clusters in the head, neck, trunk, and pubic areas (10, 37). Although predominantly benign (10), these tumors are painful and disfiguring, can undergo malignant transformation with metastasis over time, and eventually lead to mortality (38-41). Thus, the malignant features of the tumors developed on K14-CYLDm transgenic mice are in line with the clinical manifestations seen in patients. Our transgenic tumor models allowed us to define JNK/AP1 signaling cascade as a key regulator in CYLDm-driven epidermal malignancy.. Cyld loss of function is not only relevant to cutaneous adnexal tumors but also to many other cancers including SCC (22,42). It is worth noting that cyld−/− mice are sensitive to chemically induced carcinogenesis, but the tumors developed on these mice are not more malignant than those of WT mice (22). We predict that the differential tumor growth phenotypes ...
Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol. 1978 Mar; 69(3):289-98.. ...
Clear cell hidradenoma breast | travellor
clear cell hidradenoma breast Malignant clear cell hidradenoma is a rare oncologic entity and has only rarely been reported to occur in the breast. The rarity of the tumor, inconsistent nomenclature and histologic similarities with other tumors creates a diagnostic challenge [2, 4. clear cell hidradenoma breast Clear cell hidradenoma (CCH) is an uncommon skin adnexal tumor arising from eccrine glands. Although several kind of skin adnexal tumors arise in the breast tissue, CCH of the breast is an extremely rare entity. Failure to identify its
Doctors for Adnexal Tumors available in Pakistan
Timings, Address, Fee And Complete Details Of PMDC Verified Cancer Specialist / Oncologists For Treatment For Adnexal Tumors In Pakistan. Book Appointment Or Consult Online. Phone: 042-32...
Burns | Surgery Review Illustrated, 2e | AccessSurgery | McGraw-Hill Medical
The epidermis and dermis are separated by the basement membrane zone. Anchoring fibrils connect these two layers. The dermis consists of a superficial thin layer called the papillary dermis and a deep, dense layer called the reticular dermis. The primary cell of the dermis is the fibroblast that produces the collagen, elastic fibers, and ground substance that compose the bulk of the dermis. Inflammatory cells migrate through the ground substance beneath the dermis, a large plexus of arterioles and venules called the subdermal plexus. This plexus further branches into superficial smaller vessels called the papillary plexus. The skin appendages, sebaceous glands, sweat glands, and hair follicles all lie within the dermis. ...
Purpose: The hypermetabolic nature of cancer cells, especially their increased reliance on aerobic glycolysis which has been associated with more aggressive phenotype, is considered metabolic hallmarks of cancer cells including oral squamous cell carcinoma (OSCC) cells. However, its precise mechanisms remain unknown. Cylindromatosis (CYLD) is recognized as a tumor suppressor gene whereas little is available about its impact on cancer progression. Our unpublished data showed that lower CYLD expression was associated with poor prognosis in OSCC patients. The objective of our study was to address specific contributions of CYLD to the signature metabolic features of OSCC cells.. Materials and methods: We determined the level of glucose consumption as well as lactate production to evaluate the effects of CYLD knockdown by siRNA on aerobic glycolysis in human OSCC cell lines. In addition, we measured extracellular acidification and oxygen consumption rates in OSCC cells by using XF Extracellular Flux ...
Cystic Teratoma Differential Diagnoses
Teratomas are germ cell tumors commonly composed of multiple cell types derived from one or more of the 3 germ layers. Inconsistent nomenclature often confuses discussions of various subtypes of teratomas.
8390-8420) Adnexal and Skin appendage Neoplasms. *(8430-8439) Mucoepidermoid Neoplasms. *(8440-8490) Cystic, Mucinous and ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ...
Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor. Most are typically about 10 mm in size at ... Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 ... Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them. ...
Skin abscesses are common; internal abscesses tend to be harder to diagnose, and more serious. Skin abscesses are also ... Even without treatment, skin abscesses rarely result in death, as they will naturally break through the skin. ... Cox, Carol Turkington, Jeffrey S. Dover ; medical illustrations, Birck (2007). The encyclopedia of skin and skin disorders (3rd ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... Metastatic carcinoma. *Giant-cell tumor of the tendon sheath. *Glomus tumor. *Granular cell tumor ... A dermatofibroma, or benign fibrous histiocytomas, is a benign skin growth. ... Dermatofibromas are classed as benign skin lesions, meaning they are completely harmless, though they may be confused with a ...
2% vehicle). Erythema was the most frequently reported local skin reaction. Severe local skin reactions reported by Aldara- ... Basal-cell carcinoma. *Wart (caused by the Human papillomavirus; also similar in appearance to molluscum) ... Molluscum contagiosum (MC), sometimes called water warts, is a viral infection of the skin that results in small, raised, pink ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ...
Systemic lupus erythematosus
Skin. As many as 70% of people with lupus have some skin symptoms. The three main categories of lesions are chronic cutaneous ( ... Micrograph of a section of human skin prepared for direct immunofluorescence using an anti-IgG antibody. The skin is from a ... Direct immunofluorescence can detect deposits of immunoglobulins and complement proteins in the people's skin. When skin not ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
This may result in areas of the skin turning darker or lighter than the color of the skin on the rest of the body. Because of ... The fact that eTG has been found in precipitates of skin-bound IgA from skin affected by this condition has been used to ... Squamous-cell carcinoma. *Basal-cell carcinoma. *Merkel-cell carcinoma. *Nevus sebaceous. *Trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *Wart. *Callus ...
They can sometimes occur on the thicker palmar or plantar skin surfaces. Corns form when the pressure point against the skin ... Because diabetes affects the capillaries, the small blood vessels which feed the skin, thickening of the skin with callus ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... It is the natural reaction of the palmar or plantar skin. Too much friction occurring too fast for the skin to develop a ...
... when the skin is exposed to ultraviolet light from the sun. Small amounts of sun exposure can make melasma return to the skin ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... Tunzi, M; Gray, GR (January 2007). "Common skin conditions during pregnancy". Am Fam Physician. 75 (2): 211-18. PMID 17263216. ...
Marie Antoinette syndrome
Conditions of the skin appendages. *Marie Antoinette. *Syndromes. Hidden categories: *Articles needing expert attention with no ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
... virus 2 is typically contracted through direct skin-to-skin contact with an infected individual, but can also be ... Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978- ...
Porphyria cutanea tarda
Though blisters are the most common skin manifestations of PCT, other skin manifestations like hyperpigmentation (as if they ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... The dermatological symptoms of PCT that include blistering and lesions on sun-exposed areas of the skin are caused by a buildup ...
... and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... and in areas where the skin folds. Flakes may be yellow, white or grayish. Redness and flaking may also occur on the skin ... Jeanette Jacknin (2001). Smart Medicine for Your Skin: A Comprehensive Guide to Understanding Conventional and Alternative ...
Disseminated intravascular coagulation
Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... or bleeding into the skin. Complications may include organ failure. ...
It may be applied to the skin as a cream or ointment. If the reaction covers a relatively large portion of the skin or is ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... A barrier cream, such as those containing zinc oxide (e.g., Desitin, etc.), may help protect the skin and retain moisture. ...
... and inflamed skin. Areas of the skin rich in oil-producing glands are often affected including the scalp, face, and chest.[2 ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... and in areas where the skin folds. Flakes may be yellow, white or grayish. Redness and flaking may also occur on the skin ... the colonization rate of affected skin may be lower than that of unaffected skin. ...
Diseases of the skin and appendages by morphology. Growths. Epidermal. *Wart. *Callus ... Squamous-cell carcinoma. *Basal-cell carcinoma. *Merkel-cell carcinoma. *Nevus sebaceous. *Trichoepithelioma ... Elston, William D. James, Timothy G. Berger, Dirk M. (2006). Andrew's diseases of the skin: clinical dermatology (10 ed.). ... Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal ...
An average of 3 to 4 treatments are required for warts on thin skin. Warts on calloused skin like plantar warts might take ... Callus, seborrheic keratosis, squamous cell carcinoma. Treatment. Salicylic acid, cryotherapy. ... Warts are typically small, rough, and hard growths that are similar in color to the rest of the skin. They typically do ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ...
... (or nevi if multiple) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa.[1 ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) ...
Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Keloids expand in claw-like growths over normal skin. They have the capability to hurt with a needle-like pain or to itch, ... Most skin injury types can contribute to scarring. This includes burns, acne scars, chickenpox scars, ear piercing, scratches, ...
... which connects the lower skin layer (dermis) to the upper skin layer (epidermis) and keeps it attached to the body. ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... When the condition is active, the basement membrane is dissolved by the antibodies produced, and areas of skin lift away at the ...
Positive skin smears.. Skin lesions can be single or many, and usually hypopigmented, although occasionally reddish or ... It is characterized by one or more hypopigmented skin macules and patches where skin sensations are lost because of damaged ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... The skin can crack and if the skin injuries are not carefully cared for and rested, there is a risk for a secondary infection ...
Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Any part of the skin surface can be involved. Oral lesions are present in a minority of cases. The disease may be acute, but ... Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately ...
Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Some of these skin infections are known as ringworm or tinea. Toenail and fingernail infections are referred to as ... Infected hair shafts are broken off just at the base, leaving a black dot just under the surface of the skin. Scraping these ...
... and in areas where the skin folds. Flakes may be yellow, white or grayish. Redness and flaking may also occur on the skin ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... the colonization rate of affected skin may be lower than that of unaffected skin. ...
Vary JC, Jr (November 2015). "Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis". The Medical clinics of ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... The underlying skin is unscarred and looks superficially normal. Although these patches can take many shapes, they are usually ... Skin Conditions: Alopecia Areata Archived 2007-12-17 at the Wayback Machine.. WebMD. Retrieved on December 2, 2007. ...
Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one ... skin appendage (8390-8429). *sweat gland *Hidrocystoma. *Syringoma. *Syringocystadenoma papilliferum. Cystic, mucinous,. and ... particularly breast and lung carcinoma. It is not associated with H. pylori infection or chronic gastritis. The risk factors ...
Skin disorders: (cicatricial) skin lesions, hypopigmentation. Infection late in gestation or immediately following birth is ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... Infectious skin disease: Viral cutaneous conditions, including viral exanthema (B00-B09, 050-059) ...
This reddened skin or rash may signal a deeper, more serious infection of the inner layers of skin. Once below the skin, the ... Cellulitis is caused by a type of bacteria entering the skin, usually by way of a cut, abrasion, or break in the skin. This ... This article is about infection of skin and its underlying connective tissue. For the dimpled appearance of skin, see cellulite ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
The physical examination of the skin and its appendages, as well as the mucous membranes, forms the cornerstone of an accurate ... Diseases of the skin include skin infections and skin neoplasms (including skin cancer). ... The two main types of human skin are glabrous skin, the nonhairy skin on the palms and soles (also referred to as the " ... Layer of skin involved. Main article: Integumentary system. The skin weighs an average of 4 kg (8.8 lb), covers an area ...
Vary JC (November 2015). "Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis". The Medical Clinics of North ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ... and accumulation of skin cells in the hair follicle. In healthy skin, the skin cells that have died come up to the surface ... Skin care. In general, it is recommended that people with acne do not wash affected skin more than twice daily. The ...
Tumours and skin outgrowths also induce localized baldness (sebaceous nevus, basal cell carcinoma, squamous cell carcinoma). ... Vary JC, Jr (November 2015). "Selected Disorders of Skin Appendages--Acne, Alopecia, Hyperhidrosis". The Medical Clinics of ... Scalp reduction is the process is the decreasing of the area of bald skin on the head. In time, the skin on the head becomes ... "Skin Therapy Letter. 17 (6): 1-4. PMID 22735503. Archived from the original on 2015-12-12.. Cite uses deprecated parameter , ...
The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... skin appendage (8390-8429). *sweat gland *Hidrocystoma. *Syringoma. *Syringocystadenoma papilliferum. Cystic, mucinous,. and ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ...
ಕುಷ್ಠರೋಗ - ವಿಕಿಪೀಡಿಯ
2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.. CS1 maint: Explicit use of ... squamous cell carcinoma. *basal cell carcinoma. *merkel cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Job C, Jayakumar J, Aschhoff M (1999). ""Large numbers" of Mycobacterium leprae are discharged from the intact skin of ... Ishida Y, Pecorini L, Guglielmelli E (2000). "Three cases of pure neuritic (PN) leprosy at detection in which skin lesions ...
Oral squamous cell carcinoma (SCC). SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Genital lichen planus, which may cause lesions on the glans penis or skin of the scrotum in males, and the vulva or vagina in ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... It is found that cutaneous lichen planus does not carry a risk of skin cancer. In contrast to cutaneous LP, which is self ...
Insect bites and stings
any exposed skin. painful and immediate. Painful welt, several hours.. bed bugs. appendages, neck, exposed skin. usually not. ... and Squamous Cell Carcinomas". Am J Pathol. 24 (2): 367-387. PMC 1942711 . PMID 18904647.. ... exposed appendages. often[dubious - discuss]. Low raised welt, itches several hours.. midges and no-see-ums. exposed appendages ... The skin reaction to insect bites and stings usually lasts for up to a few days. However, in some cases the local reaction can ...
"Skin Therapy Letter. 13 (7): 1-4. PMID 18839042.. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z Neville BW, Damm DD, ... Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma. ... aphthous stomatitis may be three times more common in white-skinned people than black-skinned people. ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *Wart. *Callus ...
skin appendage (8390-8429). *sweat gland *Hidrocystoma. *Syringoma. *Syringocystadenoma papilliferum. Cystic, mucinous,. and ... Papilloma/carcinoma. (8010-8139). *Small cell carcinoma. *Combined small cell carcinoma. *Verrucous carcinoma ...
Category:Infobox medical condition (new)
Adnexal and skin appendage neoplasms. *Adnexal mass. *Adrenal crisis. *Adrenal insufficiency. *Adrenal tumor ... Acquired cystic kidney disease-associated renal cell carcinoma. *Acquired generalized lipodystrophy. *Acquired non-inflammatory ...
skin appendage (8390-8429). *sweat gland *Hidrocystoma. *Syringoma. *Syringocystadenoma papilliferum. Cystic, mucinous,. and ... as is seen in hepatocellular carcinoma. ... Lobular carcinoma. *Lobular carcinoma in situ. *Invasive ...
It may be applied to the skin as a cream or ointment. If the reaction covers a relatively large portion of the skin or is ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Diseases of the skin and appendages by morphology. Growths. Epidermal. *wart. *callus ... A barrier cream, such as those containing zinc oxide (e.g., Desitin, etc.), may help protect the skin and retain moisture. ...
... s are involved in skin problems such as acne and keratosis pilaris. In the skin pores, sebum and keratin can ... Sebaceous carcinoma, an uncommon and aggressive cutaneous tumour.. *Sebaceous cyst is a term used to refer to both an ... "Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages". Histochemistry and ... "Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface". 10 May 2011.. ...
印戒细胞癌 - 维基百科，自由的百科全
Adnexal and skin appendage（英语：Adnexal and skin appendage neoplasms） (8390-8429). *汗腺 *Hidrocystoma（英语：Hidrocystoma） ... Medullary carcinoma（英语：Medullary carcinoma）. *Medullary carcinoma of the breast（英语：Medullary carcinoma of the breast） ... Lobular carcinoma（英语：Lobular carcinoma）. *Lobular carcinoma in situ（英语：Lobular carcinoma in situ） ... Ductal carcinoma（英语：Ductal carcinoma）. *Mammary ductal carcinoma（英语：Mammary ductal carcinoma） ...
Tumors: Skin neoplasm, skin appendages / Adnexal and skin appendage (C44.L40-L68/D23.L15-49, 173/216) ... There are three main types of skin cancer: basal-cell skin cancer (basal-cell carcinoma) (BCC), squamous-cell skin cancer ( ... Larger defects may require repair with a skin graft, local skin flap, pedicled skin flap, or a microvascular free flap. Skin ... "Squamous cell carcinoma (epidermoid carcinoma) - skin". Atlas of Pathology (3rd ed.). Universitatii St., Iasi, Romania. ...
... is a long-term skin condition characterized by patches of the skin losing their pigment. The patches of skin ... Skin with vitiligo, when exposed to a blacklight, will glow blue. In contrast, healthy skin will have no reaction.[citation ... If the affected person is pale-skinned, the patches can be made less visible by avoiding tanning of unaffected skin. ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
... is a benign condition characterized by hyperplasia of the epidermis and epithelium of skin appendages, with irregular ... "Pseudoepitheliomatous hyperplasia: A clinical entity mistaken for squamous cell carcinoma". Journal of Cutaneous and Aesthetic ... Skin color. The amount and distribution of melanin pigment in the epidermis is the main reason for variation in skin ... Skin hydration. The ability of the skin to hold water is primarily due to the stratum corneum and is critical for ...
PPT - Brooke-Spiegler Syndrome PowerPoint Presentation - ID:156085
Brooke-Spiegler syndrome - Dermatology Advisor
Patients with multiple skin appendage tumors usually beginning to appear in the second or third decade. The family history ... Trichoepitheliomas should be distinguished from basal cell carcinoma. Painful spiradenoma may be mistaken for a leiomyoma, ... "Andrews diseases of the skin". Clinical Dermatology. 2006. (Detailed textbook especially about clinical dermatology. Skin ... The appendage tumors show their classical features.. Trichoepithelioma: Different-sized nests or cribriform cords consisting of ...
Carcinoma, Skin Appendage | Profiles RNS
Skin Appendage" by people in this website by year, and whether "Carcinoma, Skin Appendage" was a major or minor topic of these ... Skin Appendage*Carcinoma, Skin Appendage. *Appendage Carcinoma, Skin. *Appendage Carcinomas, Skin. *Carcinomas, Skin Appendage ... "Carcinoma, Skin Appendage" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Carcinoma, Skin Appendage" by people in Profiles. ...
The Mammary Bud as a Skin Appendage: Unique and Shared Aspects of Development | SpringerLink
Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early ... Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85(6):841-51.PubMed ... Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. Early ... Homeobox genes Msx-1 and Msx-2 are associated with induction and growth of skin appendages. J Invest Dermatol 1995;104(5):711-9 ...
Carcinoma - Wikipedia
8390-8420) Adnexal and Skin appendage Neoplasms. *(8430-8439) Mucoepidermoid Neoplasms. *(8440-8490) Cystic, Mucinous and ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ...
Brovana (Arformoterol Tartrate Inhalation Solution): Side Effects, Interactions, Warning, Dosage & Uses
Bicalutamide - FDA prescribing information, side effects and uses
Skin and Appendages:. Dry Skin; Alopecia; Pruritus; Herpes Zoster; Skin Carcinoma; Skin Disorder ... Skin and subcutaneous tissue disorders: Photosensitivity. Drug Interactions. Clinical studies have not shown any drug ... Prostatic carcinoma is known to be androgen sensitive and responds to treatment that counteracts the effect of androgen and/or ... A small increase in the incidence of hepatocellular carcinoma in male mice given 75 mg/kg/day of Bicalutamide (approximately 4 ...
Lioresal Intrathecal - FDA prescribing information, side effects and uses
Skin and Appendages: Rash, sweating, alopecia, contact dermatitis and skin ulcer.. Special Senses: Abnormality of accommodation ... Body as a Whole: Death, fever, abdominal pain, carcinoma, malaise and hypothermia. ... Skin and Appendages: Alopecia and sweating.. Metabolic and Nutritional Disorders: Weight loss, albuminuria, dehydration and ... Place the template on the skin over the pump, and align the refill template. Align the right edge of the template with the ...
BROVANA®(arformoterol tartrate) Inhalation Solution 15 mcg*/2 mL
Respiratory: carcinoma of the lung, respiratory disorder, voice alteration Skin and Appendages: dry skin, herpes simplex, ... herpes zoster, skin discoloration, skin hypertrophy Special Senses: abnormal vision, glaucoma Urogenital: breast neoplasm, ... arformoterol caused a statistically significant increase in the incidence of thyroid gland c-cell adenoma and carcinoma in ...
DailyMed - TIZANIDINE HYDROCHLORIDE - tizanidine hydrochloride tablet
Skin and Appendages Frequent: Rash, sweating, skin ulcer. Infrequent: Pruritus, dry skin, acne, alopecia, urticaria. Rare: ... skin carcinoma. Special Senses Infrequent: Ear pain, tinnitus, deafness, glaucoma, conjunctivitis, eye pain, optic neuritis, ... Rare: Carcinoma, congenital anomaly, suicide attempt. Cardiovascular System Infrequent: Vasodilatation postural hypotension, ...
Skin Appendage Tumors Seem on the Rise in U.S. | Health24
Cutaneous appendageal carcinoma incidence rates are increasing in the United States, especially for sebaceous carcinoma, ... Skin Appendage Tumors Seem on the Rise in U.S.. Cancer of sweat glands most common, but cases of eyelid cancer also up, study ... MONDAY, June 21 (HealthDay News) -- Tumors of skin appendages, such as sweat glands, mammary glands, hair and nails, appear to ... Rates of sweat gland cancer increased 170 percent and rates of cancers of the eyelid glands (sebaceous carcinomas) increased ...
Intrathecal Baclofen Therapy - Post-Implant Follow-Up | Medtronic
Skin and Appendages: Rash, sweating, alopecia, contact dermatitis and skin ulcer.. Special Senses: Abnormality of accommodation ... Body as a Whole: Death, fever, abdominal pain, carcinoma, malaise and hypothermia. ... Skin and Appendages: Alopecia and sweating.. Metabolic and Nutritional Disorders: Weight loss, albuminuria, dehydration and ... The pump is refilled by inserting a needle through the skin into the pump septum. A refill template, included in the Lioresal ...
Intrathecal Baclofen Therapy - Patient Selection Considerations by Condition | Medtronic
Skin and Appendages: Rash, sweating, alopecia, contact dermatitis and skin ulcer.. Special Senses: Abnormality of accommodation ... Body as a Whole: Death, fever, abdominal pain, carcinoma, malaise and hypothermia. ... Skin and Appendages: Alopecia and sweating.. Metabolic and Nutritional Disorders: Weight loss, albuminuria, dehydration and ... implant depth greater than 2.5 cm below skin; insufficient body size; and spinal anomalies. Use of the system with drugs with ...
Advanced Search Results - Public Health Image Library(PHIL)
Acinic cell carcinoma
ICD-9 142.0 ICD-O: M8550/3 Acinic cell carcinoma is a tumor most ... Adnexal And Skin appendage (8390-8429). sweat gland ( ... Acinic cell carcinoma Acinic cell carcinomaClassification & external resources ICD-10 C07. ... Papilloma/carcinoma (8010-8139). Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - ... Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor ...
PPT - Diseases of the Skin Appendages PowerPoint Presentation - ID:76728
Diseases of the Skin Appendages. Adam Wray, D.O. September 13, 2005. Non-scarring alopecias. Alopecia areata. Characterized by ... Adrenal causes include congenital adrenal hyperplasia and adrenal tumors such as adrenal adenomas and carcinomas ... Skin Theory -. skin theory skin disorders skin care. dermatology. the study of skin, its structures, function, diseases and ... Chapter 6: Skin and Its Appendages -. introduction. skin (integument) is the bodys largest organ approximately 1.6 to 1.9 m 2 ...
Neoral (Cyclosporine): Uses, Dosage, Side Effects, Interactions, Warning
Skin and Appendages: abnormal pigmentation, angioedema, dermatitis, dry skin, eczema, nail disorder, pruritus, skin disorder, ... Of the 16 patients with skin cancer, 11 patients had 18 squamous cell carcinomas and 7 patients had 10 basal cell carcinomas. ... Neoplasms: skin malignancies [squamous cell (0.9%) and basal cell (0.4%) carcinomas];. Reticuloendothelial: platelet, bleeding ... The most common forms of neoplasms are non-Hodgkinâ€™s lymphoma and carcinomas of the skin. The risk of malignancies in ...
External Ear Inflammatory Diseases: Overview, Immunologic and Inflammatory Disorders, Traumatic Disorders
... and all associated appendages. The skin and cartilage of the ear are subject to the same insults as similar tissues found ... Differential diagnoses include basal cell carcinoma, squamous cell carcinoma, and premalignant keratoses. To exclude these ... The patch test is compared with an area of skin that is exposed only to UV-A light and to an area of skin that has been treated ... Dry atrophic skin with telangiectasias, mottled hyperpigmentation and hypopigmentation, and loss of appendages characterizes ...
Squamous Cell Carcinoma of the Vulva
May involve the skin appendages in 50% of cases. Abnormal mitoses consistently present in VIN 2 and 3 ... Inverted follicular keratosis of the vulvar skin: a lesion that can be confused with squamous cell carcinoma. ... MICROINVASIVE SQUAMOUS CELL CARCINOMA (THIN) 1A carcinoma. Defined as a single lesion measuring 2 cm or less in diameter and ... Verrucous carcinoma (VC) of the vulva is a rare variant of squamous cell carcinoma (SCC) of the vulva that afflicts older women ...
FLOT2 Gene - GeneCards | FLOT2 Protein | FLOT2 Antibody
Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the ... Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. ...
Anti-Flotillin 2/ESA antibody (ab96507) | Abcam
In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the ... Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma ... Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. ...
INTERROGATORIO GINECOLOGICO PDF
Epidermal thickness and skin appendage involvement in vulvar intraepithelial neoplasia. Husseinzadeh N, Recinto C. How to cite ... Treatment of intraepithelial carcinoma of the vulva by skin excision and graft. ... Involvement of the vulval skin appendages by intraepithelial neoplasia. Am J Clin Pathol. ... Analysis of alterations adjacent to invasive vulvar carcinoma and their relationship with associated carcinoma: J Natl Cancer ...
Flotillin 2 293T transfected lysate (ab94259) | Abcam
Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the ... Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. Similarity: Belongs to the band 7/ ...
Multiple endocrine neoplasia
Adnexal And Skin appendage (8390-8429). sweat gland (Hidrocystoma, Syringoma). Cystic, Mucinous And Serous (8440-8499). ( ... Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - Signet ring cell carcinoma/Krukenberg tumor ... Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous ... Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the ...
Basal Cell Carcinoma of the Female Breast Masquerading as Invasive Primary Breast Carcinoma: An Uncommon Presentation Site
It comprises two types: melanoma and nonmelanoma skin cancers. Of the nonmelanomas, basal cell carcinoma (BCC) constitutes ... We present a case of a Caucasian woman who presented with what was initially thought to be invasive carcinoma of the breast ... The importance of this case lies in the rare site of presentation of basal cell carcinoma and the importance of early detection ... Skin cancer as a single entity is the most common malignancy in North America, accounting for half of all human cancers. ...
Brooke-Spiegler Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Carcinoma, Skin Appendage 45 Eccrine Dermal Cylindroma 74 Skin Appendage Carcinoma 17 ... skin,NS,carcinoma,basal cell carcinoma c.5825G,A. p.G1942E. 16:72796857-72796857. 0. ... skin,NS,carcinoma,basal cell carcinoma c.11050G,A. p.D3684N. 16:72787226-72787226. 0. ... skin,NS,carcinoma,basal cell carcinoma c.1991C,T. p.S664F. 16:72958155-72958155. 0. ...
Treatment of basal cell carcinomas at high risk for recurrence
... is a common skin cancer that arises from the basal layer of epidermis and its appendages. Treatment of BCC is indicated due to ... the locally invasive, aggressive, and destructive effects of BCC on skin and surrounding tissues ... Basal cell carcinoma (BCC) is a common skin cancer that arises from the basal layer of epidermis and its appendages. Treatment ... Therapeutic ionizing radiation and the incidence of basal cell carcinoma and squamous cell carcinoma. The New Hampshire Skin ...
Frederick A. Leaf, M.D. | Seattle, WA
Squamous Cell Carcinoma Of Skin Of Lip. *Squamous Cell Carcinoma Of The Skin ... Malignant Neoplasm Of Skin Appendages. *Mastocytosis. *Melanoma On Ear. *Melanoma On Face ... The skin is often a reflection of the state of the body, in general. Therefore, a holistic approach to skin care is important. ...
Prescribing Information - Avonex® (Interferon beta-1a)
Skin and Appendages: basal cell carcinoma, blisters, cold clammy skin, contact dermatitis, erythema, furunculosis, genital ... Insert the needle with a quick dart-like thrust at a 90o angle, through the skin and into the muscle. Expect to feel some ... 2. With one hand stretch the skin taut around the injection site. Hold the syringe with the other hand, making sure it is ... 1. Use a new alcohol wipe to clean the skin at one of the recommended intramuscular injection sites. Pull the protective cover ...
Skin Tumor Markers | SpringerLink
The most common malignant tumors of skin are basal-cell carcinomas, and the next... ... Skin cancers are the most common malignant tumors of man, constituting approximately one-third of all human cancers. ... A variety of other malignancies arise from specialized cells present in skin or its appendages, but these are very rare and ... The most common malignant tumors of skin are basal-cell carcinomas, and the next most common are squamous-cell carcinomas. The ...
Epithelioma adenoides cysticum | Article about epithelioma adenoides cysticum by The Free Dictionary
A tumor derived from epithelium; usually a skin cancer, occasionally cancer of a mucous membrane. a benign or malignant tumor ... mainly of the skin and its appendages. In the USSR, the term is applied only to several rare skin tumors, for example, blue ... It was formerly used to designate basal cell carcinoma (basal cell epithelioma) and squamous cell carcinoma of the skin ( ... A tumor derived from epithelium; usually a skin cancer, occasionally cancer of a mucous membrane. ...
Paraffin waxes and Hydrocarbon waxes,... - Registration Dossier - ECHA
Two tumours originating from the skin appendages, a squamous cell carcinoma and a benign trichoepithelioma, were observed in ... A lifetime skin painting carcinogenicity study of petroleum waxes (Klimisch score = 2) was conducted in mice and rabbits ( ... cortical adenomas with a few carcinomas and pheochromocytomas) and of the pituitary. The number of tumour-bearing animals and ...
NeoplasmsBasalTumorTumorsBasal cell carcinomasAdnexalNeoplasmsSquamous Cell Carcinoma of theSituIncidenceEpidermalLesionsEpithelialMalignancy of the skinCutaneousMetastatic carcinomaEpidermis and its appendagesCancersAdenocarcinomaEyelidNonmelanoma skin cancerLesionAbstractBenignVulvaFair-skinned personsDiseasesArisesDermis2017Eccrine carcinomaSebaceous carcinomaAdenosquamous carcinomaDiagnosisSmall cell carcBreast CarcinomaOccurHistologicallyCancerDifferentiationVulvar intraepitLymph nodesNeuroendocrineMucousGlandsSyndromeMerkelAlopeciaSalivaryClinicopathologicTumourClinical
- Patients with multiple skin appendage tumors usually beginning to appear in the second or third decade. (dermatologyadvisor.com)
- The family history reveals similar multiple skin tumors involving relatives of the affected patient. (dermatologyadvisor.com)
- The appendage tumors show their classical features. (dermatologyadvisor.com)
Basal cell carcinomas8
- Of the 3.5 million cases of nonmelanoma skin cancer (NMSC) diagnosed each year, 80% are basal cell carcinomas (BCCs), which makes BCCs the most common skin cancer [ 2 ]. (hindawi.com)
- Individuals with Brooke-Spiegler syndrome are also at increased risk of developing tumors in tissues in other areas, particularly benign or malignant tumors of the salivary or parotid glands and basal cell carcinomas. (malacards.org)
- The most common malignant tumors of skin are basal-cell carcinomas, and the next most common are squamous-cell carcinomas. (springer.com)
- Although basal-cell carcinomas grow slowly and only very rarely metastasize, they do invade locally and cause considerable destruction of adjacent tissues, which can result in disfigurement. (healingcancernaturally.com)
- Although multiple basal cell carcinomas may develop early in life as an inherited trait (nevoid basal cell carcinoma syndrome, or as a complication of xeroderma pigmentosum), most arise later. (healingcancernaturally.com)
- See 'Treatment of basal cell carcinomas at high risk for recurrence' . (uptodate.com)
- The clinical presentation of trichilemmal carcinoma is variable, as it may mimic basal cell carcinomas and squamous cell carcinomas, thus requiring histologic diagnosis. (bvsalud.org)
- Most basal cell carcinomas are caused by chronic sun exposure, especially in people with fair skin, light hair and blue, green or grey eyes. (highlandsscc.com.au)
- Microcystic adnexal carcinoma. (umassmed.edu)
- It was therefore proposed that all cases of extramammary Paget's disease arose as epidermotropic spread from an in situ or invasive neoplasm arising in an adnexal gland within the dermis, analogous to mammary Paget's disease arising from ductal carcinoma in situ. (bmj.com)
- Adnexal clear cell carcinoma with comedonecrosis (ACCCC) is a very rare malignancy of the skin with an aggressive clinical course and a predilection for the scalp. (elsevier.com)
- Abstract: Trichilemmal carcinoma is a rare adnexal neoplasia with histologic features reminiscent of the outer root sheath of hair follicles. (bvsalud.org)
- Refers to a heterogeneous group of high-grade carcinomas that feature cells lacking distinct histological or cytological evidence of any of the more specifically differentiated neoplasms . (wikipedia.org)
Squamous Cell Carcinoma of the2
- High-grade vulval intraepithelial neoplasia VIN 3: Carcinoma in situ of the vulva. (no-pasaran.mobi)
- In situ and invasive vulvar cancer incidence trends to Intraepithelial carcinoma of the vulva. (no-pasaran.mobi)
- Surgical approach to interrogstorio carcinoma in situ of the vulva. (no-pasaran.mobi)
- We report a case of an axillary lymph node containing benign glandular lesions, intraductal papilloma with florid and atypical duct hyperplasia, and ductal carcinoma in situ. (biomedsearch.com)
- In one of these cases, ductal carcinoma in situ (DCIS) has been described as arising in a background of intraductal papilloma in an axillary lymph node. (biomedsearch.com)
- The true incidence of VIN probably is higher, because generally only a subset, carcinoma in situ (VIN 3) cases, is reported. (springer.com)
- The prevailing view is that most, if not all, cases of mammary Paget's disease originate from in situ or invasive ductal carcinoma in the underlying breast tissue. (bmj.com)
- Cutaneous appendageal carcinoma incidence rates are increasing in the United States, especially for sebaceous carcinoma, perhaps related to improved recognition and classification, but factors such as UV exposure and immunosuppression may also play a role,' Patrick W. Blake and colleagues said in a news release from the publisher. (health24.com)
- Skin cancers occur in highest incidence on the exposed skin of the head and neck of persons chronically exposed to sunlight. (healingcancernaturally.com)
- The incidence and prevalence of skin cancer can be greatly reduced by simple preventive measures, such as avoidance of exposure to the Sun and to excessive ionizing radiation. (healingcancernaturally.com)
- Avoidance of unnecessary sunlight and careful control of ionizing radiation significantly lowers the incidence of basal cell carcinoma. (healingcancernaturally.com)
- Squamous cell carcinoma and basal cell carcinoma account for 95% of cases of nonmelanomatous skin cancer, and the incidence of squamous cell carcinoma has been increasing. (mdedge.com)
- In skin, expressed in epidermis and epidermal appendages but not in dermis. (abcam.com)
- Epidermal thickness and skin appendage involvement in vulvar intraepithelial neoplasia. (no-pasaran.mobi)
- Tissue specificity: In skin, expressed in epidermis and epidermal appendages but not in dermis. (abcam.com)
- Benedet JL, Wilson PS, Matisic J (1991) Epidermal thickness and skin appendage involvement in vulvar intraepithelial neoplasia. (springer.com)
- The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby affect the response of BCC to topical treatment. (hindawi.com)
- The stratum corneum (SC) is the outermost epidermal layer of the skin. (hindawi.com)
- Squamous Cell Carcinoma SCC is a major type of cancer that arises from the outer epidermal layer of the skin and mucous membranes and occurs most commonly on areas exposed to the sun. (highlandsscc.com.au)
- Serious skin reactions (e.g., toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme) have been reported in patients receiving BEXTRA. (wikidoc.org)
- Atopic dermatitis, also known as eczema, is a systemic disease that manifests as intensely pruritic, erythematous, skin lesions. (medscape.com)
- Human Papillomavirus (HPV) Profiles of Vulvar Lesions: Possible Implications for the Classification of Vulvar Squamous Cell Carcinoma Precursors and for the Efficacy of Prophylactic HPV Vaccination. (thedoctorsdoctor.com)
- To analyze the impact of HPV profiles of vulvar precancerous lesions for their classification and to assess the presumable efficacy of the prophylactic HPV vaccination, 269 vulvar excisions representing lichen sclerosus, lichen simplex chronicus, condylomata acuminata, d-VIN, all grades of u-VIN and squamous cell carcinomas were subjected to the HPV typing by use of GP5+/6+ polymerase chain reaction and reverse line blot hybridization. (thedoctorsdoctor.com)
- The lesions occur in fair-skinned persons and on areas of skin that receive the greatest exposure to sunlight. (healingcancernaturally.com)
- All squamous cell carcinoma lesions are thought to begin via the repeated, uncontrolled division of cancer stem cells of epithelial lineage or characteristics. (enacademic.com)
- BEXTRA should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. (wikidoc.org)
- Unlike basal cell carcinoma, which usually arises de novo, squamous cell carcinoma often arises from precursor lesions, such as actinic keratosis and Bowen disease. (mdedge.com)
- Like other skin appendages, the embryonic mammary gland develops via extensive epithelial-mesenchymal interactions. (springer.com)
- Carcinoma is a category of types of cancer that develop from epithelial cells . (wikipedia.org)
- Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. (hindawi.com)
Malignancy of the skin2
- Because these cutaneous appendageal carcinomas are still rare, research into them has been limited. (health24.com)
- Further increases in cutaneous appendageal carcinomas over time should prompt new strategies for cancer screening and early intervention of this cancer. (health24.com)
- The Merkel cell carcinoma, also known as cutaneous neuroendocrine carcinoma, is a very rare and aggressive neoplasm. (bvsalud.org)
- The immunohistochemical study reveals that it is a cutaneous neuroendocrine carcinoma, exeresis is performed with negative histological edges, but after a few months it relapses, so a deeper surgery is performed and it is accompanied by chemotherapy. (bvsalud.org)
- Merkel cell carcinoma accounts for less than 1 of cutaneous malignancies, and an etiologic role for chronic sun exposure has been proposed. (mussenhealth.us)
- Cutaneous lymphoma, characterized by atypical proliferation of T or B lymphocytes in the skin, usually presents as a slow-growing indurated nodule or plaque. (mdedge.com)
- Bicalutamide tablets 50 mg daily is indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D 2 metastatic carcinoma of the prostate. (drugs.com)
- There was no evidence of invasive or metastatic carcinoma. (biomedsearch.com)
- Hycamtin is indicated for the treatment of: metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy. (cancermonthly.com)
Epidermis and its appendages2
- spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
- Rates of sweat gland cancer increased 170 percent and rates of cancers of the eyelid glands (sebaceous carcinomas) increased 217 percent. (health24.com)
- Skin cancer as a single entity is the most common malignancy in North America, accounting for half of all human cancers. (hindawi.com)
- It comprises two types: melanoma and nonmelanoma skin cancers. (hindawi.com)
- Of the nonmelanomas, basal cell carcinoma (BCC) constitutes about 80% of the cancers diagnosed every year. (hindawi.com)
- Generally, they could be divided into two types: melanoma and nonmelanoma skin cancers. (hindawi.com)
- She had no prior personal or family history of skin and breast cancers. (hindawi.com)
- Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which are known collectively as nonmelanoma skin cancer, are two of the most common malignancies in the United States and are often caused by sun exposure, although several hereditary syndromes and genes are also associated with an increased risk of developing these cancers. (oncolink.org)
- Treatment of hereditary skin cancers is similar to the treatment of sporadic skin cancers. (oncolink.org)
- Most of the psychosocial literature about hereditary skin cancers has focused on patients with familial melanoma. (oncolink.org)
- Squamous cell carcinoma is one of the most common cancers in humans and other animals, and usually arises from mutated ectodermal or endodermal cells lining body cavities. (enacademic.com)
- Skin cancers are less common among black skinned races. (highlandsscc.com.au)
- Melanoma is a deadly skin cancer and if not treated early accounts for 70% of deaths from skin cancer and common skin cancers which have grown too large, or have spread throughout the body, accounts for the remaining 30% of skin cancer deaths. (highlandsscc.com.au)
- Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus at least a 10% component of cells characteristic of more highly differentiated types (i.e. adenocarcinoma and/or squamous cell carcinoma). (wikipedia.org)
- Adenoid Squamous Cell Carcinoma, also known as adenocarcinoma with squamous metaplasia , is related to angiosarcoma and eyelid carcinoma . (malacards.org)
Nonmelanoma skin cancer3
- Melanoma is less common than nonmelanoma skin cancer, but 5% to 10% of all melanomas arise in multiple-case families and may be inherited in an autosomal dominant fashion. (oncolink.org)
- Person with 1 nonmelanoma skin cancer are at increased risk of developing others in the future. (blogspot.com)
- The rate of new nonmelanoma skin cancer is 35% at 3 years and 50% at 5 years after an initial diagnosis of skin cancer. (blogspot.com)
- Although not specific to atopic dermatitis, affected skin exhibits white dermatographism (ie, appearance of a white line when the lesion is stroked). (medscape.com)
- Once the lesion has grown and progressed to the point where it has breached, penetrated, and infiltrated adjacent structures, it is referred to as " invasive " squamous cell carcinoma. (enacademic.com)
- [ 7 ] Approximately 3 to 90 days after the initial exposure (average 21 days) a skin lesion, called a chancre , appears at the point of contact. (gutenberg.cc)
- Verrucous carcinoma of the vulva appears as a large condyloma or a lesion suspicious for invasive carcinoma. (glowm.com)
- We describe a case of DEC presenting as an eczematous, crusted skin lesion on the right nipple-areolar complex in a 67-year-old woman. (yonsei.ac.kr)
- A healthy 68-year-old farmer presents with an asymptomatic skin lesion on his right arm that appeared spontaneously without trauma or bite 5 months ago and has grown progressively since then. (mdedge.com)
- Not to be confused with carcinoid , which is sometimes a type of carcinoma but is more often benign. (wikipedia.org)
- Two tumours originating from the skin appendages, a squamous cell carcinoma and a benign trichoepithelioma, were observed in the wax-painted groups. (europa.eu)
- 5) We describe yet another case of intraductal carcinoma arising in a background of intraductal papilloma with atypical duct hyperplasia and adjacent benign glandular inclusions. (biomedsearch.com)
- We concur with the theory that the intraductal carcinoma probably arose from the benign glandular inclusions. (biomedsearch.com)
- Malignancies arising from benign glandular inclusions in lymph nodes have rarely been described in pelvic lymph nodes containing mullerian carcinomas, (6,7) thyroid, (8) salivary glands, (9) and the axilla. (biomedsearch.com)
- 1-5) In the axilla, benign heterotopic glands are hypothesized to arise from breast or skin appendage glands by theories of implantation, metaplasia, or embryonal rests. (biomedsearch.com)
- 10) The coexistence of benign glandular inclusions and intraductal carcinoma in axillary lymph nodes lends support to the theory that the former led to the latter. (biomedsearch.com)
- Treatment of intraepithelial carcinoma of the vulva by skin excision and graft. (no-pasaran.mobi)
- Benedet JL, Miller DM, Ehlen TG et al (1997) Basal cell carcinoma of the vulva: clinical features and treatment results in 28 patients. (springer.com)
- 1 Verrucous carcinoma may involve large areas of the vulva, and it has a pushing rather than an infiltrative border. (glowm.com)
- It is most common among fair-skinned persons, with a lifetime risk of 33% to 39% in white men and 23% to 28% in white women in the United States [ 1 ]. (hindawi.com)
- Here, we review what is known of the molecular and cellular mechanisms controlling early steps in the development of these organs, attempt to unravel both common themes and unique aspects that can begin to explain the diversity of appendage formation, and discuss human genetic diseases that affect appendage morphogenesis. (springer.com)
- With over 30 years in private practice as a respected dermatologist, Dr. James Hu utilizes careful observation and thoughtful analysis to treat a variety of common and rare skin, hair and nail diseases. (swedish.org)
- Psoriasis can be hard to diagnose because it can look like other skin diseases. (larpring.de)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. (larpring.de)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish. (larpring.de)
- Find a Dermatologist American Academy of Dermatology National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish. (larpring.de)
- The primary NIH organization for research on Psoriasis is the National Institute of Arthritis and Musculoskeletal and Skin Diseases. (larpring.de)
-  Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal , mesodermal  or ectodermal germ layer during embryogenesis . (wikipedia.org)
- It arises from basal cells in the deepest layer of the skin (the undifferentiated basal keratinocytes of the epidermis). (healingcancernaturally.com)
- Squamous-cell carcinoma arises from the platelike flat cells that constitute the major cellular component of skin. (healingcancernaturally.com)
- Marjolin's ulcer is a type of squamous cell carcinoma that arises from a non-healing ulcer or burn wound. (enacademic.com)
- however, the diagnosis was revealed to be a basal cell carcinoma after histopathological examination. (hindawi.com)
- Because of the high rate of metastasis of squamous cell carcinomas, early diagnosis is important, especially in persons with a skin ulcer that fails to heal. (healingcancernaturally.com)
- Genetic testing, Psoriasis vulgaris Form for HLA-Cw6 is a Psoriasis vulgaris Form aid to diagnosis, although most diagnosis is done quite easily on the basis of the skin presentation. (festival-celle.de)
Small cell carc8
- Compared to non-small cell carcinoma, small cell carcinoma has a shorter doubling time, higher growth fraction, and earlier development of metastases. (omicsgroup.org)
- Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. (omicsgroup.org)
- Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. (omicsgroup.org)
- Lambert-Eaton myasthenic syndrome (LEMS) is a well-known paraneoplastic condition linked to small-cell carcinoma. (omicsgroup.org)
- Histopathologic image of small-cell carcinoma of the lung. (omicsgroup.org)
- [ 7 ] Approximately half of all individuals diagnosed with Lambert-Eaton myasthenic syndrome (LEMS) will eventually be found to have a small-cell carcinoma of the lung. (omicsgroup.org)
- Small-cell carcinoma is most often more rapidly and widely metastatic than non-small cell lung carcinoma [ 8 ] (and hence staged differently). (omicsgroup.org)
- Very rarely, the primary site for small-cell carcinoma is outside of the lungs and pleural space, it is referred to as extrapulmonary small-cell carcinoma (EPSCC). (omicsgroup.org)
- Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant . (wikipedia.org)
- Small-cell lung carcinoma can occur in combination with a wide variety of other histological variants of lung cancer , [ 9 ] including extremely complex malignant tissue admixtures. (omicsgroup.org)
- Although more likely to develop in fair-skinned individuals, squamous cell carcinoma may occur in dark-skinned people, especially at sites of preexisting inflammatory conditions or burns. (highlandsscc.com.au)
- Lipoatrophy and skin necrosis may occur. (copaxone.com)
- The spectrum of HPV types found in vulvar squamous cell carcinomas indicates that the efficacy of HPV vaccination in preventing vulvar cancer might be diminished in the studied population, because the recently developed prophylactic vaccines are targeted against a limited number of HPV types. (thedoctorsdoctor.com)
- Analysis of alterations adjacent to invasive vulvar carcinoma and their relationship with associated carcinoma: J Natl Cancer Inst. (no-pasaran.mobi)
- Skin cancer as a single entity is the most common malignancy in North America [ 1 ]. (hindawi.com)
- usually a skin cancer, occasionally cancer of a mucous membrane. (thefreedictionary.com)
- Skin cancer is one of the most common forms of cancer in humans. (healingcancernaturally.com)
- The behaviour of squamous-cell carcinoma differs somewhat from that of basal-cell cancer, in that the cells are not only capable of local invasion but also may metastasize to regional lymph nodes and, rarely, to more distant sites. (healingcancernaturally.com)
- Squamous cell carcinoma is also an occupational hazard, as was noted at the end of the 19th century in regard to chimney sweeps who contracted cancer after exposure to tars. (healingcancernaturally.com)
- Expert-reviewed information summary about the genetics of skin cancer - basal cell carcinoma, squamous cell carcinoma, and melanoma - including information about specific gene mutations and related cancer syndromes. (oncolink.org)
- The summary also contains information about interventions that may influence the risk of developing skin cancer in individuals who may be genetically susceptible to these syndromes. (oncolink.org)
- This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the genetics of skin cancer. (oncolink.org)
- This executive summary reviews the topics covered in this PDQ summary on the genetics of skin cancer, with hyperlinks to detailed sections below that describe the evidence on each topic. (oncolink.org)
- Several genes and hereditary syndromes are associated with the development of skin cancer. (oncolink.org)
- Risk-reducing strategies for individuals with an increased hereditary predisposition to skin cancer are similar to recommendations for the general population, and include sun avoidance, use of sunscreen, use of sun-protective clothing, and avoidance of tanning beds. (oncolink.org)
- To receive news and publication updates for Journal of Skin Cancer, enter your email address in the box below. (hindawi.com)
- It is the most common type of invasive skin cancer in the fair skinned population of the world, causing significant patient morbidity, and should be managed properly [ 2 ]. (hindawi.com)
- Skin cancer kills more than 1,000 Australians each year. (highlandsscc.com.au)
- There are three main types of skin cancer - Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC) and Melanoma. (highlandsscc.com.au)
- Rare skin cancer types include - Merkel Cell Carcinoma, Keratoacanthoma, skin appendage cancer. (highlandsscc.com.au)
- Basal Cell Carcinoma BCC is the most common form of skin cancer. (highlandsscc.com.au)
- Although this skin cancer rarely spreads (metastasizes) to other organs of the body, it can cause destruction of surrounding tissue. (highlandsscc.com.au)
- Malignant Melanoma is a serious form of skin cancer of melanocytes, the cells that produce dark protective pigment called melanin. (highlandsscc.com.au)
- Melanoma may spread to other organs, making it essential to treat this skin cancer early. (highlandsscc.com.au)
- Basal Cell Carcinoma (BCC) is the most common skin cancer. (blogspot.com)
- Refers to a carcinoma with observable features and characteristics indicative of squamous differentiation (intercellular bridges, keratinization, squamous pearls). (wikipedia.org)
- Trichofolliculomas are believed to represent abortive differentiation of pluripotent skin cells on their way to develop into hair follicles. (mussenhealth.us)
- Due to its high grade neuroendocrine nature, small-cell carcinomas can produce ectopic hormones , including adrenocorticotropic hormone (ACTH) and anti-diuretic hormone (ADH). (omicsgroup.org)
- In addition, because of their neuroendocrine cell origin, small-cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome . (omicsgroup.org)
- The most common tumours were those of the mammary regions (fibrocarcinomas, adenocarcinomas, fibromas, and sarcomas), of the adrenal glands (cortical adenomas with a few carcinomas and pheochromocytomas) and of the pituitary. (europa.eu)
- It originates in the pilo-sebaceous glands , and is similar in clinical presentation and microscopic analysis to squamous cell carcinoma, except that it contains a central keratin plug. (enacademic.com)
-  This neoplasm is thought to arise from sebaceous glands in the skin and, therefore, may originate anywhere in the body where these glands are found. (wikipedia.org)
- Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them. (wikipedia.org)
- Typically, 3-month-old K5-CYLD C/S mice exhibit a phenotype characterized by alopecia and kyphosis, and, the histological examination reveals that transgenic mice show signs of accelerated aging in numerous organs such as skin, thymus, pancreas, liver and lung. (aging-us.com)
- Skin/Appendages: Total alopecia (grade 2) occurred in 31% of patients. (cancermonthly.com)