Carcinoma, Signet Ring Cell
Proto-Oncogene Proteins B-raf
Carcinoma, Squamous Cell
Loss of Heterozygosity
Signet ring cell carcinoma of the stomach: a clinicopathological comparison with the other histological types. (1/223)A retrospective analysis was carried out on 93 patients with signet ring cell carcinoma of the stomach operated on between 1985 and 1995, to review the clinicopathologic characteristics from the database of gastric cancer at Sendai National Hospital. The results were compared with those for 590 patients with other types of gastric carcinoma. Women were afflicted as commonly as men in the signet ring cell carcinoma group. These patients tended to be younger and to have larger tumors. The histological type was commonly scirrhous and infiltrative. The survival of patients with signet ring cell carcinoma was worse than that of patients with other types of gastric cancer but the difference was not statistically significant. Patients with early signet ring cell carcinoma had a good prognosis, similar to that of the other groups. However, prognosis of patients with advanced signet ring cell carcinoma was poor compared with patients with other types of this disease. In multivariate analysis, the statistical significant prognostic factors were vascular microinvasion and tumor location. These findings suggest that signet ring cell carcinoma of the stomach should be regarded as a distinct type of gastric cancer. (+info)
alpha-catenin-deficient F9 cells differentiate into signet ring cells. (2/223)It has been demonstrated that alpha-catenin is frequently lost in diffuse type adenocarcinomas. We have isolated alpha-catenin-deficient mouse teratocarcinoma F9 cells by gene targeting. Wild-type F9 cell aggregates cultured in the presence of retinoic acid differentiated into embryoid bodies with an outer layer of epithelial cells. In contrast, cell aggregates of alpha-catenin-deficient cells did not develop outer layers under the same conditions. The outer surface cells of alpha-catenin-deficient cell aggregates, however, differentiated into epithelial cells as determined by their expression of epithelial marker proteins. These differentiated cells scattered from aggregates and showed signet ring cell morphology, which is frequently observed in diffuse type adenocarcinomas. We have provided clear evidence that a single mutation in the alpha-catenin gene may be a direct cause not only of the scattered properties of cells but also of signet ring cell formation in diffuse type adenocarcinoma. (+info)
Chylothorax, chylopericardium and lymphoedema--the presenting features of signet-ring cell carcinoma. (3/223)This report describes a patient with chylous pleural and pericardial effusions in conjunction with severe lymphoedema resembling elephantiasis. The chylous effusions and generalized lymphoedema were associated with a signet-ring cell carcinoma. (+info)
Identification of natural antigenic peptides of a human gastric signet ring cell carcinoma recognized by HLA-A31-restricted cytotoxic T lymphocytes. (4/223)Peptides of human melanomas recognized by CD8+ CTLs have been identified, but the nature of those of nonmelanoma tumors remains to be elucidated. Previously, we established a gastric signet ring cell carcinoma HST-2 and HLA-A31 (A*31012)-restricted autologous CTL clone, TcHST-2. In the present study, we determined the natural antigenic peptides of HST-2 cells. The purified preparation of acid-extracted Ags was submitted to the peptide sequencer, and one peptide, designated F4.2 (Tyr-Ser-Trp-Met-Asp-Ile-Ser-Cys-Trp-Ile), appeared to be immunogenic. To confirm the antigenicity of F4.2 further, we constructed an expression minigene vector (pF4.2ss) coding adenovirus E3, a 19-kDa protein signal sequence plus F4.2. An introduction of pF4.2ss minigene to HST-2 and HLA-A31(+) allogeneic tumor cells clearly enhanced and induced the TcHST-2 reactivity, respectively. Furthermore, when synthetic peptides of F4.2 C-terminal-deleted peptides were pulsed to HST-2 cells, F4.2-9 (nonamers), but not F4.2-8 or F4.2-7 (octamer or heptamer, respectively), enhanced the reactivity of TcHST-2, suggesting that the N-terminal ninth Trp might be a T cell epitope. This was confirmed by lack of antigenicity when using synthetic substituted peptides as well as minigenes coding F4.2 variant peptides with Ala or Arg at the ninth position of F4.2. Meanwhile, it was indicated that the sixth position Ile was critically important for the binding to HLA-A31 molecules. Thus, our data indicate that F4.2 may work as an HLA-A31-restricted natural antigenic peptide recognized by CTLs. (+info)
Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. (5/223)To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer. (+info)
Radiologic findings of metastatic signet ring cell carcinoma to the breast from stomach. (6/223)Two Korean women (41 and 23-years of age) presented with painful breast enlargement and redness. The involved breast was confirmed as metastatic signet ring cell carcinoma. Although metastatic signet ring cell carcinoma of the breast shows similar clinical symptoms to inflammatory breast cancer, the difference between the two is that this malignancy showed no microcalcifications or mass on radiographic findings (mammograms and US). Therefore, after the confirmation of signet ring cell carcinoma of the breast has been made, metastatic signet ring cell carcinoma should be considered if there are no microcalcifications or masses evident on radiographic findings. (+info)
Node-positive mucosal gastric cancer: a follow-up study. (7/223)BACKGROUND: Lymph node metastasis from mucosal gastric carcinoma is rare and the prognosis of the patients has seldom been reported. METHODS: Forty-five patients with node-positive mucosal gastric cancer were studied. They accounted for 2.5% of 1770 patients with mucosal gastric cancer who underwent gastrectomy with lymphadenectomy at the National Cancer Center Hospital, Tokyo. The clinicopathological features were studied and the current clinical status was sought. RESULTS: The majority of patients (87%) were treated with D2 lymphadenectomy. The metastasis was confined to the perigastric nodes (pN1 by Japanese classification) in 30 patients (67%). The number of positive nodes was less than seven (pN1 by TNM) in 42 patients (93%). Two patients had para-aortic nodal metastasis. The median follow-up period was 11 years. Four patients died of definite or possible recurrent disease and the disease-specific 5- and 10-year survival rates were 95 and 89%, respectively. CONCLUSIONS: Although nodal metastasis is an important prognostic factor for gastric cancer, the prognosis was excellent as long as the primary tumor was confined to the mucosa and was treated with gastrectomy and lymphadenectomy. (+info)
Collecting-duct carcinoma of the kidney with prominent signet ring cell features. (8/223)We report a case in a 74-year-old woman of collecting-duct carcinoma of the kidney with prominent signet ring cell features. Grossly, the tumor measured 5.5 cm in greatest dimension, occupied the entire upper pole of the kidney, and was well circumscribed. Microscopically, it displayed a predominant tubulopapillary pattern of growth with a hyalinizing stroma. The tumor tubules were lined by a single layer of cells with large, pleomorphic nuclei, some of which had a hobnail appearance. Large intracytoplasmic vacuoles with compression of nuclei (signet ring cells) were present throughout the tumor. Alcian blue, mucicarmine, and periodic acid-Schiff stains failed to identify intracellular mucin or glycogen in the signet ring cells. Enlarged cells with intracytoplasmic vacuoles were also noted in the adjacent collecting ducts. The tumor cells were immunohistochemically positive for cytokeratin including cytokeratin 7, CAM 5.2, AE1/3, and 34 beta E12, vimentin, peanut lectin agglutinin, and Ulex europaeus agglutinin. Electron microscopy revealed that the intracytoplasmic vacuoles were due to intracellular edema. To the best of our knowledge, this is the first reported case of renal collecting-duct carcinoma with prominent signet ring cell features. (+info)
A rare type of carcinoma that develops in the gastrointestinal tract (GI tract) such as stomach, small intestine, or large intestine is known as signet ring cell carcinoma. This cancerous tumor is characterized by its appearance under a microscope, which displays cells arranged in a signet ring pattern.
These cells have a distinctive round nucleus and prominent nucleoli that give them a characteristic signet ring appearance. Signet ring cell carcinomas tend to grow slowly, and they do not typically cause any symptoms until they reach an advanced stage.
Signet ring cell carcinoma can be difficult to diagnose because it often looks like other types of noncancerous conditions, such as inflammation or infection. To diagnose this condition, a healthcare provider will need to perform tests such as endoscopy, imaging studies (such as CT scan or MRI), and biopsy.
Treatment options for signet ring cell carcinoma include surgery to remove the tumor, chemotherapy, radiation therapy, or a combination of these. Treatment decisions depend on the stage of the cancer, location, and other factors such as patient's overall health status and personal preferences.
In summary, signet ring cell carcinoma is a rare type of gastrointestinal tract cancer characterized by its distinctive signet ring appearance under a microscope. It tends to grow slowly and can be difficult to diagnose until it reaches an advanced stage. Treatment options include surgery, chemotherapy, radiation therapy, or combination of these depending on the stage of the cancer and other factors.
American Cancer Society. (2022). Signet Ring Cell Carcinoma of the Stomach. Retrieved from
National Cancer Institute. (2022). Signet Ring Cell Carcinoma of the Gastrointestinal Tract. Retrieved from
Examples of 'Adenocarcinoma, Mucinous' in medical literature:
* The patient was diagnosed with adenocarcinoma, mucinous type, in their colon after undergoing a colonoscopy and biopsy. (From the Journal of Clinical Oncology)
* The patient had a history of adenocarcinoma, mucinous type, in their breast and was being monitored for potential recurrence. (From the Journal of Surgical Oncology)
* The tumor was found to be an adenocarcinoma, mucinous type, with a high grade and was treated with surgery and chemotherapy. (From the Journal of Gastrointestinal Oncology)
Synonyms for 'Adenocarcinoma, Mucinous' include:
* Mucinous adenocarcinoma
* Colon adenocarcinoma, mucinous type
* Rectal adenocarcinoma, mucinous type
* Adenocarcinoma of the colon and rectum, mucinous type.
There are several types of stomach neoplasms, including:
1. Adenocarcinoma: This is the most common type of stomach cancer, accounting for approximately 90% of all cases. It begins in the glandular cells that line the stomach and can spread to other parts of the body.
2. Squamous cell carcinoma: This type of cancer begins in the squamous cells that cover the outer layer of the stomach. It is less common than adenocarcinoma but more likely to be found in the upper part of the stomach.
3. Gastric mixed adenocarcinomasquamous cell carcinoma: This type of cancer is a combination of adenocarcinoma and squamous cell carcinoma.
4. Lymphoma: This is a cancer of the immune system that can occur in the stomach. It is less common than other types of stomach cancer but can be more aggressive.
5. Carcinomas of the stomach: These are malignant tumors that arise from the epithelial cells lining the stomach. They can be subdivided into adenocarcinoma, squamous cell carcinoma, and others.
6. Gastric brunner's gland adenoma: This is a rare type of benign tumor that arises from the Brunner's glands in the stomach.
7. Gastric polyps: These are growths that occur on the lining of the stomach and can be either benign or malignant.
The symptoms of stomach neoplasms vary depending on the location, size, and type of tumor. Common symptoms include abdominal pain, nausea, vomiting, weight loss, and difficulty swallowing. Diagnosis is usually made through a combination of endoscopy, imaging studies (such as CT or PET scans), and biopsy. Treatment depends on the type and stage of the tumor and may include surgery, chemotherapy, radiation therapy, or a combination of these. The prognosis for stomach neoplasms varies depending on the type and stage of the tumor, but early detection and treatment can improve outcomes.
Appendiceal neoplasms refer to abnormal growths or tumors that occur in the appendix, a small tube-like structure attached to the large intestine. These growths can be benign (non-cancerous) or malignant (cancerous). Malignant appendiceal neoplasms are rare, but they can spread quickly to other parts of the body if left untreated.
Types of Appendiceal Neoplasms:
There are several types of appendiceal neoplasms, including:
1. Adenoma: A benign tumor that arises from glandular cells in the appendix.
2. Carcinoma: A malignant tumor that arises from epithelial cells in the appendix.
3. Mucinous cystadenoma: A benign tumor that arises from glandular cells in the appendix and typically contains mucin, a type of protein.
4. Goblet cell carcinoid: A rare type of malignant tumor that arises from goblet cells, which are specialized cells that produce mucin in the appendix.
5. Signet ring cell carcinoma: A rare and aggressive type of malignant tumor that arises from glandular cells in the appendix.
Symptoms and Diagnosis:
The symptoms of appendiceal neoplasms can vary depending on the size and location of the tumor, but may include abdominal pain, nausea, vomiting, fever, and loss of appetite. Diagnosis is typically made through a combination of physical examination, imaging tests such as CT scans or MRI, and biopsy.
Treatment for appendiceal neoplasms usually involves surgical removal of the affected appendix, which may involve a laparoscopic or open procedure. In some cases, chemotherapy or radiation therapy may also be recommended to destroy any remaining cancer cells. The prognosis for patients with appendiceal neoplasms depends on the type and stage of the tumor at the time of diagnosis.
The prognosis for patients with appendiceal neoplasms is generally good if the tumor is detected early and treated appropriately. However, if the tumor is not diagnosed until a later stage, the prognosis may be poorer. The 5-year survival rate for patients with appendiceal cancer is approximately 70-80%.
Appendiceal neoplasms are rare and aggressive tumors that can arise in the appendix. Early diagnosis and treatment are critical for improving outcomes. Imaging tests such as CT scans and MRI can help identify these tumors, and surgical removal of the affected appendix is usually the first line of treatment. Chemotherapy or radiation therapy may also be recommended in some cases. The prognosis for patients with appendiceal neoplasms is generally good if the tumor is detected early, but can be poorer if not diagnosed until a later stage.
There are several subtypes of carcinoma, including:
1. Adenocarcinoma: This type of carcinoma originates in glandular cells, which produce fluids or mucus. Examples include breast cancer, prostate cancer, and colon cancer.
2. Squamous cell carcinoma: This type of carcinoma originates in squamous cells, which are found on the surface layers of skin and mucous membranes. Examples include head and neck cancers, cervical cancer, and anal cancer.
3. Basal cell carcinoma: This type of carcinoma originates in the deepest layer of skin, called the basal layer. It is the most common type of skin cancer and tends to grow slowly.
4. Neuroendocrine carcinoma: This type of carcinoma originates in cells that produce hormones and neurotransmitters. Examples include lung cancer, pancreatic cancer, and thyroid cancer.
5. Small cell carcinoma: This type of carcinoma is a highly aggressive form of lung cancer that spreads quickly to other parts of the body.
The signs and symptoms of carcinoma depend on the location and stage of the cancer. Some common symptoms include:
* A lump or mass
* Skin changes, such as a new mole or a change in the color or texture of the skin
* Changes in bowel or bladder habits
* Abnormal bleeding
The diagnosis of carcinoma typically involves a combination of imaging tests, such as X-rays, CT scans, MRI scans, and PET scans, and a biopsy, which involves removing a small sample of tissue for examination under a microscope. Treatment options for carcinoma depend on the location and stage of the cancer and may include surgery, radiation therapy, chemotherapy, or a combination of these.
In conclusion, carcinoma is a type of cancer that originates in epithelial cells and can occur in various parts of the body. Early detection and treatment are important for improving outcomes.
1. American Cancer Society. (2022). Carcinoma. Retrieved from
2. Mayo Clinic. (2022). Carcinoma. Retrieved from
3. MedlinePlus. (2022). Carcinoma. Retrieved from
MSI is a common feature of many types of cancer, including colorectal cancer, gastrointestinal cancers, and endometrial cancer. It is estimated that up to 15% of all cancers exhibit MSI, with the highest prevalence found in colon cancer (40-50%).
MSI can be caused by a variety of genetic mutations, including defects in DNA repair genes such as MLH1 and MSH2, which are involved in the repair of microsatellites. Other causes of MSI include defects in the proofreading mechanism of DNA replication and the absence of the protein that corrects errors during DNA replication.
The significance of MSI in cancer is that it can be used as a biomarker for predicting the response of cancer cells to immunotherapy, such as checkpoint inhibitors. Cancer cells that exhibit MSI are more likely to respond to these therapies and have a better prognosis compared to those that do not exhibit MSI. Additionally, MSI can be used as a predictive biomarker for the presence of Lynch syndrome, an inherited condition that increases the risk of developing colorectal cancer and other cancers.
Overall, the study of microsatellite instability is an important area of cancer research, as it can provide valuable insights into the mechanisms of cancer development and progression, and may lead to the development of new diagnostic and therapeutic strategies for cancer treatment.
Rare diseases can be caused by genetic mutations, infections, allergies, or other factors, and they can affect any part of the body. Some examples of rare diseases include cystic fibrosis, Huntington's disease, sickle cell anemia, and Tay-Sachs disease.
Because rare diseases are so uncommon, they often receive less attention and funding for research and treatment than more common conditions. However, there are organizations and resources available to support individuals with rare diseases and their families. These include patient advocacy groups, research foundations, and specialized healthcare providers.
Some of the key features of rare diseases include:
1. Low prevalence: Rare diseases affect a small percentage of the population, typically less than 1%.
2. Limited understanding: Many rare diseases are not well understood, and their causes and mechanisms are not yet fully understood.
3. Lack of effective treatments: There may be limited or no effective treatments for rare diseases, leading to a significant impact on quality of life.
4. High cost: Treatment for rare diseases can be expensive, and the financial burden can be significant for families and individuals affected.
5. Limited access to care: Due to the rarity of the disease, individuals may have limited access to specialized healthcare providers and resources.
Rare diseases are a significant public health concern, as they affect millions of people worldwide and can have a profound impact on their quality of life. There is a need for increased research, advocacy, and support for individuals with rare diseases and their families.
Adenocarcinoma is a term used to describe a variety of different types of cancer that arise in glandular tissue, including:
1. Colorectal adenocarcinoma (cancer of the colon or rectum)
2. Breast adenocarcinoma (cancer of the breast)
3. Prostate adenocarcinoma (cancer of the prostate gland)
4. Pancreatic adenocarcinoma (cancer of the pancreas)
5. Lung adenocarcinoma (cancer of the lung)
6. Thyroid adenocarcinoma (cancer of the thyroid gland)
7. Skin adenocarcinoma (cancer of the skin)
The symptoms of adenocarcinoma depend on the location of the cancer and can include:
1. Blood in the stool or urine
2. Abdominal pain or discomfort
3. Changes in bowel habits
4. Unusual vaginal bleeding (in the case of endometrial adenocarcinoma)
5. A lump or thickening in the breast or elsewhere
6. Weight loss
8. Coughing up blood (in the case of lung adenocarcinoma)
The diagnosis of adenocarcinoma is typically made through a combination of imaging tests, such as CT scans, MRI scans, and PET scans, and a biopsy, which involves removing a sample of tissue from the affected area and examining it under a microscope for cancer cells.
Treatment options for adenocarcinoma depend on the location of the cancer and can include:
1. Surgery to remove the tumor
2. Chemotherapy, which involves using drugs to kill cancer cells
3. Radiation therapy, which involves using high-energy X-rays or other particles to kill cancer cells
4. Targeted therapy, which involves using drugs that target specific molecules on cancer cells to kill them
5. Immunotherapy, which involves using drugs that stimulate the immune system to fight cancer cells.
The prognosis for adenocarcinoma is generally good if the cancer is detected and treated early, but it can be more challenging to treat if the cancer has spread to other parts of the body.
Peritoneal neoplasms are relatively rare, but they can be aggressive and difficult to treat. The most common types of peritoneal neoplasms include:
1. Peritoneal mesothelioma: This is the most common type of peritoneal neoplasm and arises from the mesothelial cells that line the abdominal cavity. It is often associated with asbestos exposure.
2. Ovarian cancer: This type of cancer originates in the ovaries and can spread to the peritoneum.
3. Appendiceal cancer: This type of cancer arises in the appendix and can spread to the peritoneum.
4. Pseudomyxoma peritonei: This is a rare type of cancer that originates in the abdominal cavity and resembles a mucin-secreting tumor.
5. Primary peritoneal cancer: This type of cancer originates in the peritoneum itself and can be of various types, including adenocarcinoma, squamous cell carcinoma, and sarcoma.
The symptoms of peritoneal neoplasms vary depending on the location and size of the tumor, but may include abdominal pain, distension, and difficulty eating or passing stool. Treatment options for peritoneal neoplasms depend on the type and stage of the cancer, but may include surgery, chemotherapy, and radiation therapy. Prognosis for peritoneal neoplasms is generally poor, with a five-year survival rate of around 20-30%.
The causes of colorectal neoplasms are not fully understood, but factors such as age, genetics, diet, and lifestyle have been implicated. Symptoms of colorectal cancer can include changes in bowel habits, blood in the stool, abdominal pain, and weight loss. Screening for colorectal cancer is recommended for adults over the age of 50, as it can help detect early-stage tumors and improve survival rates.
There are several subtypes of colorectal neoplasms, including adenomas (which are precancerous polyps), carcinomas (which are malignant tumors), and lymphomas (which are cancers of the immune system). Treatment options for colorectal cancer depend on the stage and location of the tumor, but may include surgery, chemotherapy, radiation therapy, or a combination of these.
Research into the causes and treatment of colorectal neoplasms is ongoing, and there has been significant progress in recent years. Advances in screening and treatment have improved survival rates for patients with colorectal cancer, and there is hope that continued research will lead to even more effective treatments in the future.
SCC typically appears as a firm, flat, or raised bump on the skin, and may be pink, red, or scaly. The cancer cells are usually well-differentiated, meaning they resemble normal squamous cells, but they can grow rapidly and invade surrounding tissues if left untreated.
SCC is more common in fair-skinned individuals and those who spend a lot of time in the sun, as UV radiation can damage the skin cells and increase the risk of cancer. The cancer can also spread to other parts of the body, such as lymph nodes or organs, and can be life-threatening if not treated promptly and effectively.
Treatment for SCC usually involves surgery to remove the cancerous tissue, and may also include radiation therapy or chemotherapy to kill any remaining cancer cells. Early detection and treatment are important to improve outcomes for patients with SCC.
There are several risk factors for developing HCC, including:
* Cirrhosis, which can be caused by heavy alcohol consumption, viral hepatitis (such as hepatitis B and C), or fatty liver disease
* Family history of liver disease
* Chronic obstructive pulmonary disease (COPD)
HCC can be challenging to diagnose, as the symptoms are non-specific and can be similar to those of other conditions. However, some common symptoms of HCC include:
* Yellowing of the skin and eyes (jaundice)
* Loss of appetite
* Abdominal pain or discomfort
* Weight loss
If HCC is suspected, a doctor may perform several tests to confirm the diagnosis, including:
* Imaging tests, such as ultrasound, CT scan, or MRI, to look for tumors in the liver
* Blood tests to check for liver function and detect certain substances that are produced by the liver
* Biopsy, which involves removing a small sample of tissue from the liver to examine under a microscope
Once HCC is diagnosed, treatment options will depend on several factors, including the stage and location of the cancer, the patient's overall health, and their personal preferences. Treatment options may include:
* Surgery to remove the tumor or parts of the liver
* Ablation, which involves destroying the cancer cells using heat or cold
* Chemoembolization, which involves injecting chemotherapy drugs into the hepatic artery to reach the cancer cells
* Targeted therapy, which uses drugs or other substances to target specific molecules that are involved in the growth and spread of the cancer
Overall, the prognosis for HCC is poor, with a 5-year survival rate of approximately 20%. However, early detection and treatment can improve outcomes. It is important for individuals at high risk for HCC to be monitored regularly by a healthcare provider, and to seek medical attention if they experience any symptoms.
1. Tumor size and location: Larger tumors that have spread to nearby tissues or organs are generally considered more invasive than smaller tumors that are confined to the original site.
2. Cellular growth patterns: The way in which cancer cells grow and divide can also contribute to the overall invasiveness of a neoplasm. For example, cells that grow in a disorganized or chaotic manner may be more likely to invade surrounding tissues.
3. Mitotic index: The mitotic index is a measure of how quickly the cancer cells are dividing. A higher mitotic index is generally associated with more aggressive and invasive cancers.
4. Necrosis: Necrosis, or the death of cells, can be an indication of the level of invasiveness of a neoplasm. The presence of significant necrosis in a tumor is often a sign that the cancer has invaded surrounding tissues and organs.
5. Lymphovascular invasion: Cancer cells that have invaded lymphatic vessels or blood vessels are considered more invasive than those that have not.
6. Perineural invasion: Cancer cells that have invaded nerve fibers are also considered more invasive.
7. Histological grade: The histological grade of a neoplasm is a measure of how abnormal the cancer cells look under a microscope. Higher-grade cancers are generally considered more aggressive and invasive than lower-grade cancers.
8. Immunohistochemical markers: Certain immunohistochemical markers, such as Ki-67, can be used to evaluate the proliferative activity of cancer cells. Higher levels of these markers are generally associated with more aggressive and invasive cancers.
Overall, the degree of neoplasm invasiveness is an important factor in determining the likelihood of the cancer spreading to other parts of the body (metastasizing) and in determining the appropriate treatment strategy for the patient.
Signet ring cell carcinoma
Signet ring cell
Sclerosing epithelioid fibrosarcoma
Poorly cohesive gastric carcinoma
EML4-ALK positive lung cancer
Lobular carcinoma in situ
Mucinous cystadenocarcinoma of the lung
Papillary carcinomas of the breast
High-grade prostatic intraepithelial neoplasia
Squamous cell carcinoma
Histopathology of colorectal adenocarcinoma
Mammary secretory carcinoma
Large-cell lung carcinoma with rhabdoid phenotype
Fatty liver disease
Gleason grading system
Santosh G. Honavar
Index of oncology articles
Histopathologic diagnosis of prostate cancer
Anaplastic lymphoma kinase
List of skin conditions
List of MeSH codes (C04)
International Classification of Diseases for Oncology
Primary signet-ring cell carcinoma of the urinary bladder inducing renal failure - PubMed
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Plasmacytoid/Signet Ring Cell Bladder Carcinoma
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- There were 4-318 microscopic foci of intramucosal signet ring cell adenocarcinoma in the six macroscopically normal stomachs (foci size 0.1-10 mm in diameter). (nih.gov)
- 1. [Atypical skin metastases of mucinous adenocarcinoma of the prostate with signet ring cells]. (nih.gov)
- 4. Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. (nih.gov)
- 5. [A case of mucinous cystic adenocarcinoma of the lung with signet-ring cells]. (nih.gov)
- 6. Histologic variants of adenocarcinoma and other carcinomas of prostate: pathologic criteria and clinical significance. (nih.gov)
- 9. [Comparison of clinicopathological characteristics between colorectal signet-ring cell carcinoma and mucinous adenocarcinoma]. (nih.gov)
- 10. Prostate mucinous adenocarcinoma with signet ring cell. (nih.gov)
- 12. Primary signet-ring cell adenocarcinoma of the prostate (a case report). (nih.gov)
- 18. [Cutaneous metastasis of signet ring cell adenocarcinoma]. (nih.gov)
- Gallbladder carcinoma, mainly adenocarcinoma, is a common malignant tumor in the extrahepatic biliary system [ 1 ]. (hindawi.com)
- Adenocarcinoma pobremente diferenciado en el cual el núcleo está desplazado hacia un lado por una gota citoplasmática de moco. (bvsalud.org)
- Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. (lookformedical.com)
- CRC is histologically divided into 3 categories: adenocarcinoma, mucinous adenocarcinoma, and signet ring cell type. (kjco.org)
- Correlation of E-cadherin polymorphisms to esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. (cdc.gov)
- CADM1 mRNA expression and clinicopathological significance in esophageal squamous cell carcinoma tissue. (geneticsmr.com)
- The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. (geneticsmr.com)
- Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. (lookformedical.com)
- The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells. (lookformedical.com)
- Aim: The aim of this study is to identify CCs in various histological grades of oral squamous cell carcinoma (OSCC) and to relate them with the pattern of invasion, lymphocytic response (LR), and mitotic figures (Mfs). (who.int)
- My research focuses 0n identifying the molecular and genetic characterizations of subsets of urothelial carcinoma that are associated with aggressive behavior such as small-cell carcinoma and plasmacytoid/signet ring-cell carcinoma, or those that harbor specific genetic aberrations that can be subjected to targeted therapy such as FGFR3 mutations and Her2 amplification. (sloankettering.edu)
- 8. Mucin-producing gastric cancer: clinicopathological difference between signet ring cell carcinoma and mucinous carcinoma. (nih.gov)
- Presence or history of histologically confirmed, muscle invasive, locally advanced, nonresectable, or metastatic urothelial carcinoma (that is, greater than and equal to T2). (who.int)
- 2. Must not have had urothelial carcinoma or histological variant at any site outside of the urinary bladder (that is, urethra, ureter, or renal pelvis). (who.int)
- The studies provided evidence of FAPI benefit in differentiated thyroid cancer, gastrointestinal (GI) malignancies, breast cancer, hepatocellular carcinoma, and others. (snmjournals.org)
- Accordingly, presence of enteric, clear cell, spindle cell and signet-ring cell features complicates determinating of origin of adenocarinomas. (solen.sk)
- To diagnose basal cell carcinomas, a biopsy (where tissue is taken for pathological study) is done using local anesthesia. (bionity.com)
- Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. (lookformedical.com)
- On histology, there is diffuse infiltration of single cells/cords of cells between collagen bundles within dermis, with well-differentiated signet-ring or poorly-differentiated histiocytoid cells. (cos-sco.ca)
- Linitis plastica is common in women and in poorly differentiated and signet ring cell histologies: an analysis of 217 patients (abstract). (medscape.com)
- While two recent series of prophylactic gastrectomy described microscopic foci of signet ring cell carcinoma in sample sections from 10 macroscopically normal stomachs, whole stomach phenotype has not been mapped. (nih.gov)
- Histopathology was mapped to a mucosal photograph of each stomach, enabling precise localisation of carcinoma foci, benign pathology, and mucosal zones. (nih.gov)
- Signet ring cell carcinoma is more commonly found in the stomach than at other sites of the digestive system. (deepdyve.com)
- 20. Signet-ring cell carcinoma of the gallbladder with skin metastases. (nih.gov)
- Changes of XGP have been described in kidneys destroyed as a result of pyonephrosis, in renal cell carcinoma, in transitional cell carcinoma, and, rarely, in a renal cyst. (medscape.com)
- Mixed histology tumors are allowed if urothelial differentiation (transitional cell histology) is predominant. (who.int)
- Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus. (cdc.gov)
- Histopathology: Basal cell carcinoma is a malignant epithelial tumor arising only in skin, from the basal layer of the epidermis or of the pilosebaceous adnexa. (bionity.com)
- Germ cell tumor with somatic malignant transformation is an uncommon phenomenon occurring about 7% of all mediastinal teratomas. (deepdyve.com)
- Basal cell carcinoma ( BCC ) is the most common form of skin cancer . (bionity.com)
- About two-thirds of basal cell carcinomas occur on sun-exposed areas of the body. (bionity.com)
- One-third occur on areas of the body that are not exposed to sunlight, emphasizing the genetic susceptibility of the basal cell cancer patients. (bionity.com)
- Basal Cell Carcinomas present as a firm nodule, clearly growing within the skin and below it, rather than on the surface. (bionity.com)
- Once the basal cells have invaded the deeper tissues the rolled edge disappears. (bionity.com)
- Tumor cells resemble normal basal cells (small, monomorphous) are disposed in palisade at the periphery of the tumor nests, but are spindle-shaped and irregular in the middle. (bionity.com)
- Basal cell carcinomas develop in the basal cell layer of the skin . (bionity.com)
- Basal cell carcinoma is the most common skin cancer. (bionity.com)
- Most basal cell carcinomas are removed surgically. (bionity.com)
- One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body. (lookformedical.com)
- Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation. (geneticsmr.com)
- Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS). (lookformedical.com)
- These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation. (lookformedical.com)
- Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. (lookformedical.com)
- Epithelial cells. (lookformedical.com)
- 2. Significance of signet-ring cells in patients with colorectal cancer. (nih.gov)
- from the First Affiliated Hospital of Xiamen University (China) reported on "Comparison of 68 Ga-FAPI and 18 F-FDG uptake in patients with gastric signet-ring cell carcinoma: A multicenter retrospective study" . (snmjournals.org)
- OBJECTIVES: The International Germ Cell Cancer Collaborative Group Update Consortium showed the improved survival of patients with a non-seminomatous germ cell tumor. (bvsalud.org)
- We updated the survival data of the non-seminomatous germ cell tumor patients treated at our hospital. (bvsalud.org)
- We used a web-based application of the International Germ Cell Cancer Collaborative Group Update model to calculate each patient's predicted 3-year progression-free survival. (bvsalud.org)
- XGP is characterized histologically by the presence of foamy, lipid-containing macrophages (xanthoma cells), diffuse infiltration with plasma cells, and histiocytes. (medscape.com)
- Immunohistochemistry is useful method to determine the origin of tumor in case when histomorphology alone is insufficient in poor differentatied carcinomas. (solen.sk)
- We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. (geneticsmr.com)
- An alternative mechanism is the type IV secretion apparatus induces externalization of phosphatidylserine, which resides on the inner leaflet of the cell membrane under resting conditions. (biomedcentral.com)
- It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells. (lookformedical.com)
- It is defined as a large cell enclosing a smaller one within its cytoplasm and is known by odd names such as "bird's eye cells" or "signet ring cells. (who.int)
- The gastric epithelium is comprised of a single layer of cells that invaginate to form highly organized gastric glands, populated by a distinct variety of cell types. (biomedcentral.com)
- Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. (lookformedical.com)
- When the P16 protein is expressed at a low level, it will cause cell disorders and abnormal cell growth, and ultimately, it will lead to the formation of tumors [ 4 ]. (hindawi.com)
- Cannibalism is a cell eating cell phenomenon. (who.int)