A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the LUNG.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the SKIN.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
DNA present in neoplastic tissue.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the UTERINE CERVIX.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Tumors or cancer of the BRONCHI.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Elements of limited time intervals, contributing to particular results or situations.
RNA present in neoplastic tissue.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Transplantation between animals of different species.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Antibodies produced by a single clone of cells.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Tumors or cancer of the RECTUM.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Experimentally induced tumors of the LIVER.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Tumors or cancers of the ADRENAL CORTEX.
The epithelial lining of the URINARY TRACT.
Tumors or cancer of the VULVA.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Tumors or cancer of the OROPHARYNX.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Compounds that include the amino-N-phenylamide structure.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the BILE DUCTS.
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the URINARY TRACT in either the male or the female.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Established cell cultures that have the potential to propagate indefinitely.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Organic salts and esters of benzenesulfonic acid.
Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Biochemical identification of mutational changes in a nucleotide sequence.
Excision of all or part of the liver. (Dorland, 28th ed)
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Excision of kidney.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)
Tumors of cancer of the EYELIDS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Tumors or cancer of the PHARYNX.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Tumors or cancer of the HYPOPHARYNX.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Case-control study of thyroid cancer in Northern Italy: attributable risk. (1/100)

BACKGROUND: The percentage of thyroid cancer cases attributable to specific risk factors can be calculated to focus preventive strategies. The per cent population attributable risks (PAR) for thyroid cancer were estimated in relation to history of benign thyroid diseases, history of radiotherapy, residence in endemic goitre areas and selected indicators of a poor diet, using data from a case-control study conducted between 1986 and 1992 in Northern Italy. METHODS: Cases were 399 histologically confirmed incident thyroid cancers and controls were 617 patients, admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. The PAR were computed on the basis of multivariate odds ratios (OR) and on the distribution of risk exposure among cases, assuming they are representative of the general population of cases. RESULTS: A history of benign thyroid disease accounted for 18.9% of cases, radiotherapy for 1.2%, residence for > or =20 years in endemic goitre areas for 2.4% of cases, and their combination for 21.7% of thyroid cancer cases; selected indicators of a poor diet accounted for 40.9% of thyroid cancer cases in this population. The combination of all factors considered explained over 57% of thyroid cancer cases in both sexes. The estimates for thyroid-related conditions were higher in women than men, whereas the opposite was true for dietary indicators. The overall PAR were somewhat higher in people aged > or =45 years (63.8%) than in younger subjects, and for follicular (69.1%) rather than papillary (53.7%) cancers. CONCLUSIONS: Exposure to a few simply identified and potentially modifiable risk factors or indicators (benign thyroid disease, residence in endemic goitre area and a poor diet) explained about 60% of thyroid cancer cases in this Italian population, indicating the theoretical scope for prevention.  (+info)

Mixed medullary-follicular thyroid carcinoma. Molecular evidence for a dual origin of tumor components. (2/100)

Mixed medullary-follicular carcinomas (MMFCs) are tumors of the thyroid that display morphological and immunohistochemical features of both medullary and follicular neoplasms. The histogenetic origin and possible molecular mechanisms leading to MMFCs are still unclear. To address these questions, we have isolated the two histological components of 12 MMFCs by (laser-based) microdissection, analyzed them for mutations in the RET proto-oncogene and allelic losses of nine loci on six chromosomes, and studied the clonal composition of MMFCs in female patients. Our results provide strong evidence that the follicular and medullary components in MMFCs are not derived from a single progenitor cell, because the seven tumors amenable for analysis consistently exhibited a different pattern of mutations, allelic losses, and clonal composition. We also demonstrate that follicular structures in MMFCs are often oligo/polyclonal and more frequently exhibit hyperplastic than neoplastic histological features, indicating that at least a subset of MMFCs are composed of a medullary thyroid carcinoma containing hyperplastic follicles.  (+info)

Reproductive and hormonal risk factors for thyroid cancer in Los Angeles County females. (3/100)

We conducted an individually matched case-control study (292 pairs) of female thyroid cancer patients to examine the role of reproductive history and exogenous hormones in this disease. Radiation treatment to the head or neck [28 cases and 2 controls exposed; odds ratio (OR), 14.0; 95% confidence interval (CI), 3.5-121.3] and certain benign thyroid diseases (including adolescent thyroid enlargement, goiter, and nodules or tumors) were strongly associated with thyroid cancer. Irregular menstruation increased risk (OR, 1.8; 95% CI, 0.9-3.7). Age at menarche and pregnancy history were not related to disease. Women with natural menopause and hysterectomized women without oophorectomy had no increase in risk, but disease risk was elevated in women with bilateral oophorectomy (OR, 6.5; 95% CI, 1.1-38.1). In general, use of oral contraceptives and other exogenous estrogens was not associated with thyroid cancer. However, risk increased with number of pregnancies in women using lactation suppressants (P = 0.03) and decreased with duration of breastfeeding (P = 0.04). These data provide only limited support for the hypothesis that reproductive and hormonal exposures are responsible for the marked excess of thyroid cancer risk in adult females.  (+info)

Follicular carcinoma in a functioning struma ovarii. (4/100)

We describe a case of follicular carcinoma in a functioning struma ovarii, which presented as an ovarian mass in a patient who had undergone a near-total thyroidectomy for a benign lesion. She underwent bilateral salpingo-oophorectomy and received radiotherapy and L-thyroxine treatment with no evidence of metastases in 4 years follow-up.  (+info)

Encapsulated follicular variant of papillary thyroid carcinoma with bone metastases. (5/100)

Although true follicular thyroid carcinoma is known to metastasize via the bloodstream and give rise to bone and lung metastases, such a pattern of spread is rare in papillary thyroid carcinoma. The follicular variant of papillary thyroid carcinoma (FVPTC) is believed to behave in a clinical manner similar to usual or classical papillary cancer and to follow a similar indolent course. There have been a few reports of "aggressive" FVPTC wherein follicular patterned tumors with nuclear features of papillary carcinoma have metastasized hematogenously; these neoplasms have been diffusely invasive or multicentric in the thyroid. We report five cases of FVPTC, which were encapsulated and simulated grossly and microscopically follicular adenomas. In two of these, the primary was discovered after clinical presentation of bone metastases. In three others, bony metastases (without other nonosseous metastases) arose 7 to 17 years after thyroid lobectomy for lesions initially diagnosed as follicular adenoma In retrospect, these three encapsulated lesions had vascular invasion. We wish to bring attention to these innocuous-appearing lesions, which, although sharing nuclear features of papillary cancer, behave clinically in an unexpectedly malignant fashion.  (+info)

Immunohistochemical diagnosis of papillary thyroid carcinoma. (6/100)

In thyroid, the diagnosis of papillary carcinoma (PC) is based on nuclear features; however, identification of these features is inconsistent and controversial. Proposed markers of PC include HBME-1, specific cytokeratins (CK) such as CK19, and ret, the latter reflecting a ret/PTC rearrangement. We applied immunohistochemical stains to determine the diagnostic accuracy of these three markers. Formalin-fixed, paraffin-embedded tissue from 232 surgically resected thyroid nodules included 40 hyperplastic nodules (NH), 35 follicular adenomas (FA), 138 papillary carcinomas (PC; 54 classical papillary tumors and 84 follicular variant papillary carcinomas [FVPC]), 4 follicular carcinomas (FC), 6 insular carcinomas (IC), 7 Hurthle cell carcinomas (HCC), and 2 anaplastic carcinomas (AC). HBME-1 and ret were negative in all NH and FA; some of these exhibited focal CK19 reactivity in areas of degeneration. Half of the FC and AC exhibited HBME-1 staining but no positivity for CK19 or ret. In PC, 20% of cases stained for all three markers. Classical PC had the highest positivity with staining for HBME-1 in 70%, CK19 in 80%, and ret in 78%. FVPC were positive for HBME-1 in 45%, for CK19 in 57%, and for ret in 63%; only 7 FVPC were negative for all three markers. The six IC exhibited 67% staining for HBME-1 and 50% positivity for CK19 and ret. The seven HCC had 29% positivity for HBME-1 and CK19, and 57% positivity for ret. This panel of three immunohistochemical markers provides a useful means of diagnosing PC. Focal CK19 staining may be found in benign lesions, but diffuse positivity is characteristic of PC. HBME-1 positivity indicates malignancy but not papillary differentiation. Only rarely are all three markers negative in PC; this panel therefore provides an objective and reproducible tool for the analysis of difficult thyroid nodules.  (+info)

Thyroglobulin immunoreactivity in lymph node histiocytes: a potential diagnostic pitfall. (7/100)

AIMS: Strong thyroglobulin immunoreactivity within sinus histiocytes in a lymph node draining a papillary thyroid carcinoma was observed in a recent case. This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy. METHODS: Eighty seven lymph nodes were studied from 21 cases of thyroid malignancy. These comprised papillary carcinoma (n = 12), follicular carcinoma (n = 4), medullary carcinoma (n = 3), and one case each of squamous and anaplastic carcinoma. Eleven cervical lymph nodes from patients with no evidence of thyroid disease were included as controls. Sections were stained with a monoclonal antibody against thyroglobulin. RESULTS: In the cases of thyroid malignancy, 32 of 87 lymph nodes showed positive staining for thyroglobulin of histiocytes within the subcapsular and medullary sinuses. In an additional four cases, there was positive staining of lymph within lymphatic channels. Positivity was present in at least one node in 15 of 21 cases. There was no positivity in the control cases. There was no correlation between the size of the primary tumour and the presence of thyroglobulin positivity. CONCLUSIONS: Positive staining with antithyroglobulin occurs not uncommonly in sinus histiocytes in lymph nodes draining thyroid tumours. This positivity could be the result of the destruction of normal thyroid follicles, with the release of thyroglobulin, which is taken up by histiocytes, which subsequently drain to local lymph nodes. Pathologists should be aware of this phenomenon and should be careful not to interpret this as metastatic tumour.  (+info)

Fine needle aspiration biopsy of thyroid nodules. (8/100)

BACKGROUND: Fine needle aspiration biopsy (FNA) is a routine diagnostic technique for evaluating thyroid nodules. Many reports in adults consider that FNA is superior to thyroid ultrasonography (USG) and radionuclide scanning (RS). Only five studies have been published on FNA of childhood thyroid nodules. AIMS: To investigate the reliability of FNA in the evaluation and management of thyroid nodules, and compare the results of FNA, USG, and RS with regard to final histopathological diagnosis. METHODS: FNA was performed in 46 children with thyroid nodules after USG and RS examination. We investigated the sensitivity, specificity, accuracy, and positive and negative predictive values of USG, RS, and FNA in their management. RESULTS: Six patients who had malignant or suspicious cells on FNA examination underwent immediate surgery. The other 40 patients received medical treatment according to their hormonal status. Fifteen of these nodules either disappeared or decreased in number and/or size. Surgery was performed in 25 patients who did not respond to therapy. Statistical analysis revealed sensitivity, specificity, accuracy, and positive and negative predictive values respectively as follows: 60%, 59%, 59%, 15%, and 92% for USG; 30%, 42%, 39%, 12%, and 68% for SC; 100%, 95%, 95%, 67%, and 100% for FNAB. CONCLUSION: FNAB is as reliable in children as in adults for definitive diagnosis of thyroid nodules. Using this technique avoids unnecessary thyroid surgery in children.  (+info)

The I131 Whole Body Scan is a Gamma Camera equipment based investigation. Test Type : Radiology Preparation : Inform us for your medical history to evaluate eligibility for therapy Reporting : Within 48 Hours* Components : 99m Tc- DTPA RENAL DYNAMIC SCAN (RDS) WITH GFR (GATES METHOD) Test Price: Please choose Location and other options on this page to view final cost in Delhi NCR.
Low power view demonstrates follicular cells arranged mainly in a microfollicular pattern. High power view demonstrates follicular cells with abundant cytoplasms. Nuclear features include finely granular chromatin, intranuclear cytoplasmic inclusions as well as nuclear grooves. Colloid is identified in the background. Architectural arrangement raises the possibility of a follicular lesion, however the nuclear features are in keeping with a papillary carcinoma ...
Pediatrician Dr. Jim Sears visits Texas Scottish Rite Hospital in Dallas, Texas to see how 3-D body scans are used to create customized, corrective casts for children with scoliosis.
At the heart of the uproar over full-body scans is that people are creeped out by the idea that a stranger would see a picture of them naked, much less that those images would be recorded and stored somewhere.
With the development of ZYTO biocommunication, it is easy to identify your body’s biological preference for things relating to your health
Aspartame consumption is implicated in the development of obesity and metabolic disease despite the intention of limiting caloric intake. The mechanisms responsible for this association remain unclear, but may involve circulating metabolites and the gut microbiota. Aims were to examine the impact of chronic low-dose aspartame consumption on anthropometric, metabolic and microbial parameters in a…
To date several published series have documented the difficulty in diagnosing follicular patterned lesions of the thyroid in cytology preparations 513-15]. The histologic follow-up of cases diagnosed as follicular lesions of neoplasm includes hyperplastic/adenomatoid nodules, follicular adenoma, follicular carcinoma and follicular variant of papillary carcinoma 615]. An earlier study published by Schlinkert et al from Mayo clinic showed that only 12% cases diagnosed as suspicious for follicular neoplasm on FNA were malignant on histologic follow-up. Interestingly, 27% were papillary carcinomas (majority were follicular variant) 4. Tuttle et al reported malignancy rate of 21% in their series of 149 patients diagnosed as follicular neoplasm on cytology 8. In our previous study the malignancy rate was 31% in 122 patients diagnosed as follicular neoplasm and almost half of these cases were follicular variant of papillary carcinoma.. In view of these above-mentioned studies we retrospectively ...
Quick background: I am a 26 y/o male, and I have aggressively pursued treatment of my thyroid and thyroid cancer. Here is my story and then my major question. Nov. of 2011 I went for a check-up because I was having problems focusing, getting out of bed, having energy and motivation through the day and gaining weight. Was diagnosed with Hoshimotothyroiditus. Doc asked if my thyroid was tender at all, I never noticed it before but now that he mentioned it yes it was. Ultrasound came back indicating multiple smaller nodules on the left and right lob and a larger nodule on the isthmus. Doc referred me to ENT and ENT sent me for a biopsy Jan. 13 2012, they only biopsied the nodule on the isthmus which measured 1.17x.59x1.02 CM. Biopsy indicated ( moderate groups of follicular cells, with areas of nuclear atypia, differential diagnosis, was follicular neoplasm and a follicular variant of papillary carcinoma. ENT says hes still not convinced its cancer, but wants to remove the nodule. I asked why not ...
Were all familiar with stress running the show, so next time you feel familiar anxiety creeping in, use this body scan meditation to halt it in its tracks.
The idea of body scan meditation is one of those things that you either embrace or rebel against. The thought of conducting a series of
Dr. Farkas has been my dermatologist for a few years now and she is like no other I have ever had.- Other than being highly qualified, she is so easy to talk to and will answer all of your questions with honesty. - She will let you know anything and everything about whatever skincare procedure you might be considering, and help you decide what is best for you.- Dr. Farkas has a kind, gentle demeanor, making you feel comfortable immediately and does everything possible to maintain that comfort level during your visit and/or procedure. -via Vitals. Dr. Farkas is a true example of a Dr. that cares about her patients, she gives her patients the feeling that they are the only ones that are important to her at the time… - D. Kuehm. I moved out of the area yet still return for my annual body scan (driving 1 1/2 hrs. each way). Dr. Farkas is an extremely professional and knowledgeable physician as well as personable and easy-going. - Patient ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. There are several specific inclusion and exclusion criteria (see below). When these are met, this tumor has an extremely low malignant potential. Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of ...
Mutation of the BRAF gene is common in thyroid cancer. Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous diagnostic controversies among pathologists. The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern of BRAF mutation than conventional papillary thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and (2) to study the relationship of clinicopathological features of papillary thyroid carcinomas with BRAF mutation. Tissue blocks from 76 patients with diagnostic features of papillary thyroid carcinomas (40 with conventional type and 36 with follicular variant) were included in the study. From these, DNA was extracted and BRAF V600E mutations were detected by polymerase chain reaction followed by restriction enzyme digestion and sequencing of exon 15. Analysis of the data indicated ...
TY - JOUR. T1 - Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations. AU - Attia, Doaa. AU - Lurie, Alexander. AU - Zhai, Qihui. AU - Smallridge, Robert. PY - 2020/6/30. Y1 - 2020/6/30. N2 - BCL6 corepressor like-1 (BCORL1) mutation has rarely been described in thyroid cancer or in association with BRAF mutations in any malignancy. However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the BRAF K601E and BCORL1 mutations. The patient underwent a total thyroidectomy for a 3.6 cm right thyroid nodule and a smaller lesion in the left lobe in 2007; both were FV-PTCs with no lymphovascular invasion or metastases. In 2015, a positron emission tomography-CT scan showed a small defect in the left posterior lateral fifth rib with mild increased hypermetabolic activity with standardised uptake value of 3.9 and another lesion in the right hip at the junction of the femoral neck ...
Dr. Keshab Paudel answered: Please see below: Papillary and follicular thyroid cancers are referred to as differentiated thyroid...
Recently, the rearrangement of RET proto-oncogene has been reported to be the most common genetic change in papillary thyroid carcinoma (PTC). However, its prevalence has been reported variably and its relation to clinical outcome has been controversial. The characteristic nuclear features of PTC ...
Hi, Im hoping to get some clarity on the findings of my biopsy report. I dont have it in front of me, but the report listed a few different type of cells. Follicular Carcinoma is the one my Endocron...
For the rest of the talk Im really going to treat papillary and follicular carcinomas together as far as treatment decisions are concerned. The prognostic
I have read with great interest the recent systematic review by Gartland and Lubitz. Their results and conclusion suggest that lobectomy and total …
To: David N Parente, Pim J Bongers, Raoul Verzijl, Lorne E Rotstein, Sylvia L Asa, Wouter P Kluijfhout, Karen M Devon, David P Goldstein, Ozgur Mete, Jesse D ...
The question as to whether BRAF confers a distinct biological behaviour to PTC that could have a prognostic value is still controversial. The inconsistent results described by several groups (Soares et al. 2003, Xu et al. 2003, Fugazzola et al. 2004, Trovisco et al. 2005) could be partially due to an insufficient number of patients and/or to the different combinations of various subtypes of PTC included in each study. Subtype stratification is likely to be important as BRAF is present predominantly in the classic and tall cell variants of PTC and not in the follicular variant. In our study, with classic PTC accounting for more than 50% of the total, BRAF mutation predicted an increased risk of recurrence. The univariate analysis also revealed that BRAF was associated with extra-thyroidal extension and advanced clinical stage. Indeed, larger series including mortality rate and multivariate analysis with adjustment for various confounding factors will reveal the independent prognostic role of ...
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Patient went on to have surgery. HISTOLOGY MICROSCOPIC DESCRIPTION: Paraffin sections show a moderately hypercellular meningioma with a well developed syncytial architecture. Tumour cells have uniform nuclear features. No mitotic figures or are...
One thing needs to be made very clear, there are many types of prostate cancer, the low-grade types in particular, where body scanning is overkill - its ridiculous. We know these particular types of cancer never spread, so why would we expose patients to unnecessary radiation, cost, and inconvenience looking for a cancer that we know cannot be outside the prostate. Unfortunately these sorts of well meaning scans - bone scans and CAT scans are often done on a reflex basis at the first sign of anything called cancer. But Grade 6 prostate cancers, of which there are probably close to 100,000 of these types of newly diagnosed cases every year in the US, dont need bones scans and they certainly dont need CAT scans ...
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Mahameru International offer an extensive array of services supported by well-equipped facilities to detect the onset of diseases and to provide medical care in various medical disciplines.
Mahameru International offer an extensive array of services supported by well-equipped facilities to detect the onset of diseases and to provide medical care in various medical disciplines.
Audio Dharma is an archive of Dharma talks given by Gil Fronsdal and various guest speakers at the Insight Meditation Center in Redwood City, CA. Each talk illuminates aspects of the Buddhas teachings. The purpose is the same that the Buddha had for his teachings, to guide us toward the end of suffering and the attainment of freedom.
These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited ...
The report provides comprehensive information on the therapeutics under development for Follicular Thyroid Cancer, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
FOLLICULAR NEOPLASMS (with emphasis on lesions of the inconstant portion of the hair follicle, particularly the follicular sheaths): Hair follicles are subject to a remarkable number of both inflammatory diseases, and an array of distinctive neoplasms. Follicles are epithelial structures whose histologic patterns patterns can be correlated with inherent cyclic phenomena; such correlations are a must in attempts to meaningfully classify follicular neoplasms. At regular intervals, with the phenomena of an individual follicle mostly independent of the activity of neighboring follicles, an immature follicle matures and, after an interval of generative activity, regresses to then assume a resting state; after an interval of rest, the phenomena are repeated. Inflammatory diseases, and trauma can alter the cyclic phenomena. A resting follicle is small. It composed of uniform squamous cells. Small cords of small squamous cells often project from the surface of such a structure (F5Ch12); a limited domain ...
2Department of Endocrinology, Gulhane Military Medical Academy, Ankara-Turkey Brain metastasis is an uncommon and morbid complication of thyroid carcinoma, especially follicular carcinoma. Because of its rarity, management is still debated.. A 64-year-old woman presented with signs of blindness. After ophthalmological and radiological evaluations, A frontobasal mass lesion was detected. The lesion was removed and pathological examination revealed the diagnosis of follicular thyroid carcinoma metastasis. The patient also underwent thyroidectomy, radiotherapy and chemotherapy for follicular carcinoma.. This case shows that the follicular thyroid carcinoma may present with distant metastasis even if it is a rare occurence. Keywords : Follicular thyroid carcinoma, brain metastasis, surgery ...
Purpose: To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC). Patients and Methods: Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entry was required. Each patient received dabrafenib (150 mg twice daily) for 25 days prior to thyrotropin alfa-stimulated iodine-131 whole body scan (4 mCi/148 MBq). Patients whose scan showed new sites of radioiodine uptake remained on dabrafenib for 17 more days, then were treated with 150 mCi (5.5 GBq) iodine-131. The primary end point of the study was the percentage of patients with new radioiodine uptake after treatment with dabrafenib. Results: Six of ten patients (60%) demonstrated new radioiodine uptake on whole body scan after treatment with dabrafenib. All six were treated with 5.5 GBq iodine-131. ...
The thyroid is the organ that has the greatest risk of malignant tumors among the endocrine tumors. The papillary carcinoma occupies 80% of the entire thyroid tumors. Immunohistochemical staining of galectin-3 has usually been used in differentiating papillary carcinoma and follicular carcinoma. The p53 gene of the cell cycle is a tumor suppressor gene acting in on the control points. The cyclin D1 genes in the cell cycle, involved in the implementation of G1 and S phase, plays an important role in the progression of thyroid tumors. This research compares and analyzes correlation between papillary carcinoma, follicular carcinoma, p53, cyclin D1 and galectin-3 gene expression patterns. In a total of 30 cases from papillary carcinoma, 21 cases from p53 (70%), 27 cases in galectin-3 (90%), and 26 cases in cyclin D1 (86.7%) showed positive rate. The galectin-3 staining investigated, showed a significant difference between a papillary carcinoma and a follicular carcinoma. Follicular carcinoma from 15 ...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a borderline thyroid tumour formerly known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma. The prevalence of NIFTP is estimated at 4.4-9.1% of all papillary thyroid carcinomas worldwide; however, the rate of occurrence of NIFTP is eight times lower in Asian countries than in Western Europe and America. At the molecular level, NIFTP is characterised by the lack of BRAF V600E and BRAF V600E-like mutations or other high-risk mutations (TERT, TP53) and a high rate of RAS mutations, which is similar to other follicular-pattern thyroid tumours. The diagnosis of NIFTP can only be made after histological examination of the entire tumour removed during surgery and is based on strictly defined inclusion and exclusion criteria. Although the diagnosis is postoperative, the combination of certain findings of preoperative tests including ultrasonography, cytology, and molecular testing may ...
eng] INTRODUCTION: Proliferation and apoptosis are opposing processes by which the cell numbers are kept in a delicate balance, essential for tissue homeostasis, whereas uncontrolled growth of cells is a hallmark of cancer. Papillary thyroid cancer (PTC) is the commonest type of thyroid cancer, with some PTC following an indolent course, whereas the other ones are more aggressive. AIM: To evaluate respective contribution of proliferation and apoptosis in the tumorigenesis of PTC by automated analysis. MATERIALS AND METHODS: We investigated the immunolabeling of phosphorylated histone H3 (pHH3), cyclin D1, active caspase-3, and bcl-2 in thirteen cases each of metastatic PTC, follicular variant of PTC (FVPTC), papillary microcarcinoma (PMC) and well differentiated tumor of uncertain malignant potential (WDT-UMP). FVPTC cases comprised seven encapsulated and six unencapsulated cases. RESULTS: Proliferation, as assessed by pHH3 and cyclin D1 immunolabeling, was increased in all PTC variants, ...
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Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are the two most common thyroid cancers. They account for 90% to 95% of all thyroid malignancies and are most often seen in patients over 40 years of age (1). The tumor usually presents as an asymptomatic solitary intrathyroid nodule. In patients with FTC, distant metastases at the time of diagnosis are reported in 11% to 20% of patients (2). FTC tends to metastasize hematogeneously to lung and bone, whereas PTC is commonly metastatic to regional lymph nodes and lung. Synchronous lung metastasis in both types of cancers has been reported in ∼20% of cases, with a mean age at presentation of ,50 years (3).. Despite being classified collectively as well-differentiated thyroid carcinoma, PTC and FTC have distinct clinicopathologic features, biological behavior, and clinical outcome (4, 5). FTC is generally considered to be a more aggressive tumor than PTC and is associated with a worse prognosis. Patients with FTC often present ...
Over the last decades the incidence rate of thyroid cancer increases worldwide [1]. In Saudi Arabia, thyroid carcinoma (TC) is considered the second most common cancer in young women [2]. About 80% of all TCs are PTCs. The majority of PTCs are histologically classified as conventional PTCs. The follicular variant of PTC (FVPTC) represents the largest subtype and accounts for about 30% of all PTCs [3]. Minor and rare subtypes include Hurthle cell variant PTC and insular PTC which bears an aggressive clinical behavior [4]. Conventional PTCs are characterized on the molecular level by a moderate to high frequency of BRAF mutations (40 % - 70 %) that distinguishes them from FVPTCs (10 % - 20 %) [5].. BRAF is a cytoplasmic receptor serine/threonine kinase and a key molecule in the mitogen activated protein kinase (MAPK) pathway. BRAF is mutated in diverse human malignancies although frequency and clinical presentation varies considerably between different types of cancers [6]. Over 90 % of all BRAF ...
The main nonmedullary form of thyroid cancer is papillary thyroid carcinoma (PTC) that accounts for 80-90% of all thyroid malignancies. Only 3-10% of PTC
Core needle biopsy findings of a follicular neoplasm with a macrofollicular growth pattern. The images in the left column and the right column show the core nee
Follicular thyroid cancer (FTC) is normally a much less common type of differentiated thyroid cancer. common type of differentiated thyroid cancers and spreads via haematogenous dissemination with faraway metastases taking place in 10 to 15 percent of sufferers most commonly situated in bone tissue or lungs. Based on the American thyroid association suggestions, treatment of FTC faraway metastases needs 131I so long as iodine avidity is normally conserved. We survey the initial case of an individual presenting a intensifying non resectable and iodine nonavid hepatic metastasis of FTC treated by radioembolization using hepatic selective inner rays therapy (SIRT). Case display A 69-year-old guy offered follicular thyroid cancers (T4N1M1) originally treated by total thyroidectomy and ablation of 1 bone tissue metastasis (cervical) accompanied by a first dosage of radioactive 131-iodine (131I). During 14 years follow-up, the individual provided many recurrences in bone fragments frequently, lungs, ...
Day 11: Whole Body Scan. If this {which is what I had done last month} or something very much like it is what you just had done, then the first WBS was just to determine the size of the large dose of I-131 you got on day 4.. Both scans should look pretty much the same or maybe the second scan will show something the first missed. The WBS youre taking is looking to see where gamma rays are eminating from your body. The day 2 dose {for me it was 2mCi} is much less strong than the day 4 dose {for me it was also 75 mCi}, so it will cause far fewer gamma rays {in my case something like 1/20th}. So they do the day 11 scan in order to see if the day 2 scan missed anything. The large dose will take maybe as long as 6 to 9 months to finish killing off thyroid cells, assuming it kills them all.. When do I get to be cancer free? No one has been able to answer that for me, so I doubt anyone will be able to answer it for you. Theres no way that you can know if there isnt some very small undetectable ...
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Other neoplasms affecting the age range including germ cell tumours, sarcoma, thyroid malignancy, melanoma etc. (Please note, not all these tumours will be able to be cared for by the Treat Unique team, but we will refer appropriately on to an expert in the area as appropriate ...
Dr Uday Pathak repeatedly called for a full body scan to be carried out on his wife Pradnya after he suspected she had Hodgkin's lymphoma.
The Philips Ingenia 3,0T MRI system is equipped with additional functions for oncological* and cardiological examinations.. *this is a screening method for the detection of abnormalities as early as possible, or to qualitatively evaluate an existing pathology. MRI examination is a special acquirement for oncological diagnosis as the full body scan helps to find early metastases. ...
TY - JOUR. T1 - Follicular thyroid carcinoma with skull metastases. AU - Chiofalo, Maria Grazia. AU - Setola, Sergio Venanzio. AU - Di Gennaro, Francesca. AU - Fulciniti, Franco. AU - Catapano, Giuseppe. AU - Losito, Nunzia Simona. AU - Sandomenico, Fabio. AU - Catalano, Orlando. AU - Pezzullo, Luciano. PY - 2015. Y1 - 2015. N2 - Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull. The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid ...
Factor VIII-related antigen is a recognised marker of endothelial cells. A brief immunocytochemical study of its distribution in follicular carcinoma of the thyroid and its value in the recognition of vascular invasion by this tumour has been carried out. Ten cases of follicular carcinoma of the thyroid were studied. In each strong endothelial staining was found in the majority of vessels in the adjacent normal thyroid. Lymphatic endothelium was negative. In eight of the 10 cases the staining of vessels within the tumour was absent or very weak. Staining was also absent in the majority of vessels completely occluded by tumour, but was present in the endothelium of vessels only partly occluded by tumour. It is concluded that factor VIII-related antigen staining has only limited value in the recognition of vascular invasion in follicular carcinoma. The absence of vascular staining in the tumour leads us to suggest that inhibition of factor VIII production by the tumour could be a possible ...
Results: CD56 expression was significantly higher in papillary thyroid carcinoma (PTC) (conventional and follicular variants) compared to other categories of follicular thyroid lesions, and it was significantly higher in the follicular variant of papillary carcinoma compared to follicular adenomas (FA) and hyperplastic nodules (HN). A bivariate analysis showed that the malignancy in follicular thyroid lesions was significantly associated with higher CD56 expression and older patients age. Both parameters were used to build a logistic regression model and equation for prediction of malignancy in follicular thyroid lesions. On the application of the equation to the studied cases, it was found to conform to their diagnostic nature ...
Follicular thyroid carcinoma comprises about 25% of all thyroid cancers, and its malignancy generally exceeds that of papillary carcinoma. It spreads relatively early to distant sites such as bone, lungs, and liver by invasion of blood vessels, and regional lymph nodes are usually involved only late. Production of thyroid hormones is almost exclusively associated with the follicular histologic type. In many reported cases the production of thyroid hormones by metastases has been sufficient to cause hyperthyroidism. One of these cases was that of a patient with T3 thyrotoxicosis (1).. We describe here a patient having metastatic follicular thyroid carcinoma with ...
TY - JOUR. T1 - Identification of unique, heterozygous germline mutation, STK11 (p.F354L), in a child with an encapsulated follicular variant of papillary thyroid carcinoma within six months of completing treatment for neuroblastoma. AU - Buryk, Melissa A.. AU - Picarsic, Jennifer L.. AU - Creary, Susan E.. AU - Shaw, Peter H.. AU - Simons, Jeffrey P.. AU - Deutsch, Melvin. AU - Monaco, Sara E.. AU - Nikiforov, Yuri E.. AU - Witchel, Selma Feldman. PY - 2015/7/1. Y1 - 2015/7/1. N2 - Papillary thyroid carcinoma (PTC) is rare in children, although it is a known secondary malignancy after treatment for neuroblastoma (NB). The interval between NB treatment completion and PTC is usually more than 5 years. A 4-year-old, female patient with a high risk adrenal NB was found to have a 2.9-cm, right thyroid nodule on surveillance chest computed tomography (CT) 6 months after completion of her NB treatment (induction chemotherapy, tumor resection, autologous stem cell transplantation, external beam ...
Even ME/CFS patients who are receiving treatment for thyroid disease that is non-malignant along with abnormal SPECT scans might also not improve despite hormone replacement therapy. How many of us with ME/CFS reading this are on thyroid medicine (Im raising my hand!).. In thegeneral population, thyroid malignancy is only found in approximately 0.5 - 3 patients in 100,000. As a comparision, when a subgroup of patients havning a mammography were tested for thyroid malignancy, the incidence rate was as high as 3 in 100,000. Another study revealed it was 15 per 100,000.. For ME/CFS 6,000 cases per 100,000 is a lot - especially when you compare it to the general population statistics of less than one to 3 cases per 100,000. Thats kind of scary.. For this study, there were 100 ME/CFS patients tested for thyroid malignancy. In each of these patients the diagnosis was made by ultrasonography and needle biopsy under ultrasonography. This was followed by surgical removal of the thyroid, and each case ...
We are delighted to announce another CogSci Apps™ Invention for your sleep, well-being and productivity, mySleepButton® 1.4 for iOS, which contains the worlds first personalized body scan meditation pack! Body scan meditation is a mindfulness practice that involves surveying different areas of ones body with an attitude of curiosity of acceptance.. There has been considerable research in the last several years demonstrating the helpfulness of mindfulness practices for sleep. For instance, Dr. Nancy Digdon of MacEwan University, with whom I published a study about the cognitive shuffle at SLEEP-2016, found that mindfulness predicts sleep quality. (See also Black et al, 2015).. While, mindfulness practices performed during the day can provide benefits for nocturnal sleep, a body scan meditation is also a potentially helpful pre-sleep activity. It can help one unwind from a cognitively and emotionally charged day. After such a day, before launching into a cognitive shuffle pack, you can ...
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension ...
Fingerprint Dive into the research topics of Synchronous Bony and Soft Tissue Metastases from Follicular Carcinoma of the Thyroid. Together they form a unique fingerprint. ...
Background: Recent decades have seen a rise in the incidence of well-differentiated (mainly papillary) thyroid carcinoma around the world. In Germany, the age-adjusted incidence of well-differentiated thyroid carcinoma in 2010 was 3.5 per 100 000 men and 8.7 per 100 000 women per year. Method: This review is based on randomized, controlled trials and multicenter trials on the treatment of well-differentiated thyroid carcinoma that were retrieved by a selective literature search, as well as on three updated guidelines issued in the past two years. Results: The recommended extent of surgical resection depends on whether the tumor is classified as low-risk or high-risk, so that papillary microcar cinomas, which carry a highly favorable prognosis, will not be overtreated. More than 90% of localized, well-differentiated thyroid carcinomas can be cured with a combination of surgery and radioactive iodine therapy. Radio active iodine therapy is also effective in the treatment of well-differentiated ...
Follicular patterned lesions of the thyroid are problematic and interpretation is often subjective. While thyroid experts are comfortable with their own criteria and thresholds, those encountering these lesions sporadically have a degree of uncertainty with a proportion of cases. The purpose of this review is to highlight the importance of proper diligent sampling of an encapsulated thyroid lesion (in totality in many cases), examination for capsular and vascular invasion, and finally the assessment of nuclear changes that are pathognomonic of papillary thyroid carcinoma (PTC). Based on these established criteria, an algorithmic approach is suggested using known, accepted terminology. The importance of unequivocal, clear-cut nuclear features of PTC as opposed to inconclusive features is stressed. If the nuclear features in an encapsulated, non-invasive follicular patterned lesion fall short of those encountered in classical PTC, but nonetheless are still worrying or concerning, the term ...
The PAX 8 gene has some association with follicular thyroid tumors. PAX8/PPARy rearrangement account for 30-40% of conventional type follicular carcinomas[14] and less than 5% of oncocytic carcinomas (aka Hurthle-Cell Neoplasms).[15] Tumors expressing the PAX8/PPARy are usually present in at a young age, small in size, present in a solid/nested growth pattern and frequently involve vascular invasion. It has been observed that PAX8/PPAR y-positive tumors rarely express RAS mutations in combination. This suggests that follicular carcinomas develop in two distinct pathways either with PAX8/PPAR y or RAS. Some whole-genome sequencing studies have shown that PAX8 also targets BRCA1 (carcinogenesis), MAPK pathways (thyroid malignancies), and Ccnb1 and Ccnb2 (cell-cycle processes). PAX8 is shown to be involved in tumor cell proliferation and differentiation, signal transduction, apoptosis, cell polarity and transport, cell motility and adhesion.[8]. Expression of PAX8 is increased in neoplastic renal ...
TY - JOUR. T1 - Recurrence of papillary thyroid carcinoma in a remnant pyramidal lobe. AU - Lee, Yong Sang. AU - Kim, Kuk Jin. AU - Kim, Bup Woo. AU - Chang, Hang Seok. AU - Park, Cheong Soo. PY - 2011/4. Y1 - 2011/4. UR - http://www.scopus.com/inward/record.url?scp=79952784194&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79952784194&partnerID=8YFLogxK. U2 - 10.1111/j.1445-2197.2011.05687.x. DO - 10.1111/j.1445-2197.2011.05687.x. M3 - Letter. C2 - 21418489. AN - SCOPUS:79952784194. VL - 81. SP - 304. JO - ANZ Journal of Surgery. JF - ANZ Journal of Surgery. SN - 1445-1433. IS - 4. ER - ...
TY - JOUR. T1 - Managing patients with a preoperative diagnosis of AJCC/UICC stage I (T1N0M0) papillary thyroid carcinoma. T2 - East versus west, whose policy is best?. AU - Hay, Ian D.. PY - 2010/6/1. Y1 - 2010/6/1. UR - http://www.scopus.com/inward/record.url?scp=77955551369&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=77955551369&partnerID=8YFLogxK. U2 - 10.1007/s00268-010-0469-5. DO - 10.1007/s00268-010-0469-5. M3 - Article. C2 - 20162281. AN - SCOPUS:77955551369. VL - 34. SP - 1291. EP - 1293. JO - Presentations from the 9th Annual Electric Utilities Environmental Conference. JF - Presentations from the 9th Annual Electric Utilities Environmental Conference. SN - 0364-2313. IS - 6. ER - ...
Rates of thyroid cancer have tripled in the last few decades, making it the fastest growing form of cancer. 80% of thyroid cancer cases are Papillary Thyroid Ca...
Researchers at Memorial Sloan Kettering Cancer Center did a retrospective review of patients with well-differentiated thryoid cancers: who should receive RAI?
Shutterstock. A renal specialist has warned that tens of thousands of people who have had Covid-19 may require kidney transplants or dialysis.. Donal ODonoghue, a consultant renal physician at Salford Royal NHS Trust said it is believed the kidneys may be injured by the inflammation caused by, or may be directly attacked by, Covid-19.. He told the House of Lords science and technology committee: Normally we see maybe 20% of people that go on to intensive care unit need to have a form of dialysis. During Covid it was up to 40% - and 85% of people had some degree of kidney injury.. He said this could result in tens of thousands more people requiring dialysis or kidney transplants.. The issue was reiterated by Chris Brightling, professor of respiratory medicine of the University of Leicester and the leader of a study into the long-term effects of the coronavirus, who said whole body scans of patients were showing end-organ damage in the kidneys, in the liver, in the lungs and in the ...
history of IgG monoclonal gamopathy. An ultrasound of the thyroid showed a 10 mm diameter nodule to the right and a 12 mm diameter nodule ... and the prognosis is excellent (in the case the tumor is papillary carcinoma- the most common thyroid malignancy). To conclude- .... ...
long story short, you can read my entire blog for the whole story, my new doctor ordered tests and did a biopsy. it was discovered that i had stage three, papillary cancer with follicular variant, which had spread to my lymphatic system and to two of my parathyroids. my surgery lasted almost 5 hours and was one of the most difficult ones my surgeon, who is head of the cancer department at the large hospital that i went to, had ever done.( his words- in his surgery notes) . there is no doubt in my mind that if i had continued to go to my old doctor, that i would not be here today! my endocrinologist is a caring physician, who prescribes my medication based on HOW I AM FEELING, but of course, also with my lab work in mind. i am a four year survivor as of this year. i still have to go back every six months for an ultrasound and blood work because my doctor said that my cancer was aggressive, and the risk of recurrence does not go away after five years or whatever, but could come back at any time. ...
Where other fitting methods rely on personal opinion, cycling mythology or hastily-taken tape measurements, the Body Scanning CRM uses the latest technology to ensure an exquisitely precise fit based on your exact measurements. Not only can we ensure a precise fit, but we can tailor that fit to your level of riding, from casual to performance, and to your type of bicycle, road, mountain, comfort, hybrid, even cruisers. At New Horizons were bike fit experts with over 20 years of fitting experience, always using the most up to date technolgy available.. ...
This mindful movement expands on the previous practice, working with thoughts, feelings, and sensations while in an upright posture. It also builds flexibility of body and mind.. To listen to these audio files, please enter your information in the form below. You will receive a link to the secure audio files page, as well as a username and password to access the page. Note: You will be added to our mailing list as well.. ...
Note: The determination of AJCC stage group from T, N, and M for thyroid depends on histologic type, grade, and age. The Histologies, Grade, Stage table shows the selection of the AJCC Stage table based on histology and grade. For papillary and follicular carcinomas, age is also needed for the selection; if age at diagnosis is unknown, AJCC stage will be derived as unknown for these histologies ...
DR. SAMUEL WELLS/ST. LOUIS CHILDRENS HOSPITAL: ITS KIND OF A STRANGE THING FOR A SURGEON TO SAY, BUT A MUCH BETTER WAY TO MANAGE THESE FAMILIES WOULD BE TO DO SOMETHING PREVENTATIVE. IT WILL PROBABLY BE POSSIBLE TO DEVISE SOME BIOCHEMICAL AGENT OR SOME PHARMACEUTICAL AGENT THAT WILL PREVENT PATIENTS WITH THIS DISEASE EVER FROM DEVELOPING A THYROID MALIGNANCY. )) ...
An anonymous reader writes It is now compulsory for people selected for a full body scan to take part, or they will not be allowed to fly from Heathrow or Manchester airports. There is no optional pat down. Also, a rule which meant that people under 18 were not allowed to participate in the body sc...
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Done in cases of papillary or follicular carcinoma of thyroid, medullary carcinoma of thyroid. This is now also the most common ...
"Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma". Endocrine ...
Others Thyroid lymphoma Squamous cell thyroid carcinoma Sarcoma of thyroid Hürthle cell carcinoma The follicular and papillary ... Lymphatic spread is most common in papillary carcinoma. Cervical lymph nodes become palpable in papillary carcinoma even when ... first arbitrarily coined the term "occult papillary carcinoma", in 1960, to describe papillary carcinomas ≤ 1.5 cm in diameter ... of new cases of papillary thyroid carcinoma are papillary microcarcinoma. Management strategies for incidental papillary ...
... is implicated in some follicular thyroid carcinomas and follicular-variant papillary thyroid carcinoma. The mechanism for this ... Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular ... of conventional type follicular carcinomas., and less than 5% of oncocytic carcinomas (aka Hurthle-Cell Neoplasms). Expression ... This suggests that follicular carcinomas develop in two distinct pathways either with PAX8/PPAR y or RAS. Alternate ...
... dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas". ...
A subsequent elevation of the thyroglobulin level is an indication of recurrence of papillary or follicular thyroid carcinoma. ... levels can be serially monitored in follow-up of patients with papillary or follicular thyroid carcinoma.[clarification needed ... particularly papillary or follicular thyroid cancer). Thyroglobulin is not produced by medullary or anaplastic thyroid ... the colloid is endocytosed from the follicular lumen into the surrounding thyroid follicular epithelial cells. The colloid is ...
Squamous cell carcinomas of the skin may also occur. Thyroid Two thirds of patients suffer from thyroid disorders, and these ... Cases of papillary thyroid cancer have been reported as well. Female and Male Genitourinary Females have an elevated risk of ... In the setting of thyroid cancer or a follicular adenoma, a total thyroidectomy is recommended even in cases where it appears ... It is estimated that less than 10 percent of individuals with Cowden syndrome may develop follicular thyroid cancer. ...
Incidentally detected thyroid carcinomas are more likely to be papillary thyroid carcinomas (PTCs) (Fig. 3). Incidentally ... The absence of these features does not exclude malignant tumours, especially papillary, follicular, and medullary thyroid ... Papillary thyroid carcinoma arising from a thyroglossal duct cyst in a 28-year-old male. an Axial enhanced CT scan shows a ... It is important to note that papillary carcinoma may mimic a benign-looking cyst. Simple serous cysts appear with fluid density ...
... from Encapsulated Follicular Variant of Papillary Thyroid Carcinoma to Noninvasive Follicular Thyroid Neoplasm With Papillary- ... Comprehensive microRNA expression profiling identifies novel markers in follicular variant of papillary thyroid carcinoma. ... PAX8/PPARγ Rearrangement in Thyroid Nodules Predicts Follicular-Pattern Carcinomas, in Particular the Encapsulated Follicular ... in a child with encapsulated follicular variant of papillary thyroid carcinoma within 6 months of completing treatment for ...
Maciel RM, Kimura ET, Cerutti JM (Jan 2006). "[Pathogenesis of differentiated thyroid cancer (papillary and follicular)]". Arq ... "A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression". J Clin ...
... between the V600E mutation of the BRAF oncogene and papillary thyroid cancer that cannot concentrate iodine into its follicular ... Using RT-PCR tests, it has been proved that there is no expression of NIS in cancer cells (which forms a thyroid carcinoma). ... NIS mediated uptake of iodide into follicular cells of the thyroid gland is the first step in the synthesis of thyroid hormone ... The lack of iodide transport inside follicular cells tends to cause goitres. There are some mutations in the NIS DNA that cause ...
Statistical models also allowed for the discrimination of normal thyroid from papillary thyroid carcinomas with 97.8% accuracy ... and from follicular thyroid adenomas with 94.7% accuracy. The report also demonstrated the ability of the MasSpec Pen ... The authors analyzed 160 human ovarian tissue samples, including 78 normal ovary and 82 serous carcinomas, with the MasSpec Pen ... December 2016). "Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging". ...
Strong correlation between nuclear localization of RELA and clinicopathological parameters for papillary thyroid carcinoma (PTC ... IL-8 and GST-pi in follicular thyroid carcinomas via morphoproteomic analysis. Mutations in the transactivation domain of RELA ... "Activation of nuclear factor-κB contributes to growth and aggressiveness of papillary thyroid carcinoma". Pathology, Research ... "Morphoproteomic confirmation of an activated nuclear factor-кBp65 pathway in follicular thyroid carcinoma". International ...
... examination may be necessary to distinguish a thyroid adenoma from a minimally invasive follicular thyroid carcinoma. Most ... Hyalinizing trabecular adenoma Papillary adenomata are very rare. A thyroid adenoma is distinguished from a multinodular goiter ... follicular) adenoma, particularly in larger lesions. Almost all thyroid adenomata are follicular adenomata. Follicular ... Thyroid follicular adenoma ranges in diameter from 3 cm on an average, but sometimes is larger (up to 10 cm) or smaller. The ...
... one of the Coloured Book protocols Noninvasive follicular thyroid neoplasm with papillary-like nuclear features - a tumour ... previously classified as papillary thyroid carcinoma This disambiguation page lists articles associated with the title NIFTP. ...
... follicular Thyroid carcinoma, papillary (TPC) Thyroid hormone plasma membrane transport defect Thyroid, renal and digital ... pigmentation anomaly Thumb deformity Thumb stiff brachydactyly mental retardation Thymic carcinoma Thymic epithelial tumor ... Thymoma Thymus neoplasm Thyrocerebrorenal syndrome Thyroglossal tract cyst Thyroid agenesis Thyroid cancer Thyroid carcinoma, ... erythroblastopenia of childhood Transient global amnesia Transient neonatal arthrogryposis Transitional cell carcinoma ...
... follicular MeSH C04.557.470.200.025.060.225 - carcinoma, papillary, follicular MeSH C04.557.470.200.025.075 - adenocarcinoma, ... carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell lung MeSH C04.557.470.200.360 - carcinoma, papillary ... carcinoma, papillary, follicular MeSH C04.557.470.200.025.095 - adenocarcinoma, scirrhous MeSH C04.557.470.200.025.095.410 - ... carcinoma, papillary MeSH C04.557.470.700.400 - carcinoma, squamous cell MeSH C04.557.470.700.400.130 - bowen's disease MeSH ...
I evidence to recommend its use in the setting of differentiated thyroid cancers such as papillary and follicular carcinomas. ... Squamous cell carcinoma of the thyroid gland is a rare cause of this presentation. ATC is considered an emergency cancer ... Anaplastic thyroid carcinomas, however, are histologically distinct from differentiated thyroid cancers and due to the highly ... There are a number of clinical trials for anaplastic thyroid carcinoma underway or being planned. The overall 5-year survival ...
Malignant nodules, which only occur in about 5% of nodules, include follicular, papillary, medullary carcinomas and metastases ... Follicular cells The core of a follicle is surrounded by a single layer of follicular cells. When stimulated by thyroid ... Most malignant thyroid cancers are papillary, followed by follicular, medullary, and thyroid lymphoma. Because of the ... the follicular cells reabsorb thyroglobulin from the follicular lumen. The iodinated tyrosines are cleaved, forming the thyroid ...
Abid, SA; Stack BC, Jr; Bodenner, DL (2014). "Metastatic Follicular Thyroid Carcinoma Secreting Thyroid Hormone and Radioiodine ... Yu, Run (2018). "High T3 Syndrome Associated with Metastatic Papillary and Poorly Differentiated Thyroid Cancer" (PDF). ... "Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels ... High-T3 syndrome in thyroid carcinoma may result from autonomous thyroid hormone secretion or overexpression of type 2 ...
"Nomenclature Revision for encapsulated follicular variant of papillary thyroid carcinoma: A Paradigm Shift to Reduce ... Papillary thyroid cancer or papillary thyroid carcinoma is the most common type of thyroid cancer, representing 75 percent to ... Papillary thyroid carcinoma is usually discovered on routine examination as an asymptomatic thyroid nodule that appears as a ... "Papillary Carcinomas". Archived from the original on April 19, 2010. Retrieved 2010-07-15. Ip, Yiu-Tung; Dias Filho, Marco ...
Follicular carcinoma tends to metastasize to lung and bone via the bloodstream. Papillary thyroid carcinoma commonly ... it is common to carry out hemithyroidectomy to distinguish between follicular adenoma and follicular carcinoma on ... Thus, follicular thyroid carcinomas seem to arise by two distinct and virtually nonoverlapping molecular pathways. Hurthle cell ... Like follicular carcinoma, unilateral hemithyroidectomy is performed for non-invasive disease, and total thyroidectomy for ...
... follicular renal cell carcinoma Acquired cystic kidney disease-associated renal cell carcinoma Renal cell carcinoma with t(6;11 ... Clear cell papillary renal cell carcinoma and Clear cell renal cell carcinoma with smooth muscle stroma Mucinous tubular and ... Metastatic renal cell carcinoma (mRCC) is the spread of the primary renal cell carcinoma from the kidney to other organs. 25-30 ... Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary ...
Growth pattern: solid - acinar cells, microcytic - small cystic spaces mucinous or eosinophilic, papillary-cystic - large ... cystic lined by epithelium, follicular - similar to thyroid tissue. These tumors, which resemble serous acinar cells, vary in ... "Acinic Cell Carcinoma Overview Archived 2009-12-15 at the Wayback Machine." Acinic Cell Carcinoma Information Center. Web. 07 ... "The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma". The American Journal of Surgical ...
Embryonal carcinoma and teratoma Teratoma and seminoma Choriocarcinoma and teratoma.embryonal carcinoma Others Sex cord/Gonadal ... of the testes activin receptor-like kinase-1-negative anaplastic large cell lymphoma of the testes pediatric-type follicular ... of the paratesticular structures Adenomatoid tumor Malignant and benign mesothelioma Adenocarcinoma of the epididymis Papillary ... carcinoma in situ) Specified types Tumors of one histologic type (pure forms) Seminoma Variant - Seminoma with ...
... basal cell carcinoma, and basal cell carcinoma with follicular differentiation". Int. J. Dermatol. 48 (7): 713-7. doi:10.1111/j ... CD10+ differentiates mucinous cystic neoplasms (CD10+/CK20+) from intraductal papillary mucinous neoplasm of branch duct type ( ... basal cell carcinoma with follicular differentiation (CD10 stromal and epithelial staining) and squamous cell carcinoma (strong ... Some benign T cells can be CD10+ Clear cell renal cell carcinoma (Clear cell RCC) CD10+ distinguishes renal cell carcinoma, ...
"Thyroid-like Follicular Carcinoma of the Kidney and Papillary Renal Cell Carcinoma with Thyroid-like Feature: Comparison of Two ... Thyroid-like follicular renal cell carcinoma is rare subtype of renal cell carcinoma. Li, Congcong; Dong, Hongyan; Fu, Weiwei; ...
Encapsulated follicular variant of papillary thyroid carcinoma. PTC: Papillary thyroid carcinoma. The new classification will ... showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. There are several ... Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was ... BRAF V600E mutations and RET gene fusions that are commonly seen in classical type papillary carcinoma are not seen in this ...
... showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ... "Proteomic profiling of follicular and papillary thyroid tumors". European Journal of Endocrinology. 166 (4): 657-67. doi: ...
... are considered to be medium-strength peels and affect the skin as deep as the papillary dermis.[32] Formulations of ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
... is implicated in some follicular thyroid carcinomas and follicular-variant papillary thyroid carcinoma.[10] The mechanism for ... Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular ... of conventional type follicular carcinomas[14] and less than 5% of oncocytic carcinomas (aka Hurthle-Cell Neoplasms).[15] ... This suggests that follicular carcinomas develop in two distinct pathways either with PAX8/PPAR y or RAS. ...
乳突性(英语:Papillary thyroid cancer). *濾泡性(英语:Follicular thyroid cancer)/何氏細胞(英语:Hurthle cell)(嗜酸性濾泡細胞) ... 鱗狀細胞癌(英语:Squamous-cell thyroid carcinoma). *良性
Done in cases of papillary or follicular carcinoma of thyroid, medullary carcinoma of thyroid. This is now also the most common ...
Papillary cystadenoma lymphomatosum. *Pleomorphic adenoma. *Sebaceous adenoma. *Malignant: Acinic cell carcinoma. * ... Follicular Characterized by follicular, flat, elevated or hemispherical erythematous papules with or without keratoses ... is characterized by the appearance of follicular LP on the trunk with LP follicularis decalvans on the scalp. Follicular LP on ... Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ...
Thyroid cancer (malignant): epithelial-cell carcinoma *Papillary. *Follicular/Hurthle cell. *Parafollicular cell *Medullary ...
The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary dermis ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... and the reticular dermis.[24] The superficial papillary dermis interdigitates with the overlying rete ridges of the epidermis, ...
"Squamous cell carcinoma (epidermoid carcinoma) - skin". Atlas of Pathology (3rd ed.). Universitatii St., Iasi, Romania. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... whereas it might be inadequate for invasive nodular basal-cell carcinoma or invasive squamous-cell carcinoma.[citation needed] ... sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and ...
Thyroid cancer (malignant): epithelial-cell carcinoma *Papillary. *Follicular/Hurthle cell. *Parafollicular cell *Medullary ... Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas, ... undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast-like giant cells. Solid pseudopapillary tumor is a ... The next most common type, acinar cell carcinoma of the pancreas, arises in the clusters of cells that produce these enzymes, ...
... is an uncommon and aggressive malignant cutaneous tumor.[1] Most are typically about 10 mm in size at ... Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 ... Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them.[1][2] ... This type of carcinoma is commonly managed by local resection, cryotherapy, topical chemotherapy, and radiotherapy. Multimodal ...
Malignant nodules, which only occur in about 5% of nodules, include follicular, papillary, medullary carcinomas and metastases ... Follicular cells. The core of a follicle is surrounded by a single layer of follicular cells. When stimulated by thyroid ... When the follicular cells are stimulated by thyroid-stimulating hormone, the follicular cells reabsorb thyroglobulin from the ... This is a protein within the follicular space that is originally created within the rough endoplasmic reticulum of follicular ...
Papillary cystadenoma lymphomatosum. *Pleomorphic adenoma. *Sebaceous adenoma. *Malignant: Acinic cell carcinoma. * ... Post-vaccination follicular eruption. *Lipschütz ulcer. *Eruptive pseudoangiomatosis. *Viral-associated trichodysplasia. * ...
Papillary cystadenoma lymphomatosum. *Pleomorphic adenoma. *Sebaceous adenoma. *Malignant: Acinic cell carcinoma. * ... Post-vaccination follicular eruption. *Lipschütz ulcer. *Eruptive pseudoangiomatosis. *Viral-associated trichodysplasia. * ...
Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma. *Microcystic ... Pigmented AKs: gray to brown dots or globules surrounding follicular openings, and annular-granular rhomboidal structures; ... Moy, RL (Jan 2000). "Clinical presentation of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ...
Aggressive digital papillary adenocarcinoma. *Extramammary Paget's disease. Ungrouped. *Merkel cell carcinoma. *Microcystic ... Post-vaccination follicular eruption. *Lipschütz ulcer. *Eruptive pseudoangiomatosis. *Viral-associated trichodysplasia. * ...
Thyroglobulin (TG) levels can be elevated in well-differentiated papillary or follicular adenocarcinoma. It is often used to ... "Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma". Thyroid. 25 (6): 567-610. ...
Thyroid cancer (malignant): epithelial-cell carcinoma *Papillary. *Follicular/Hurthle cell. *Parafollicular cell *Medullary ... Sipple JH (1961). "The association of pheochromocytoma with carcinoma of the thyroid gland". Am. J. Med. 31: 163-6. doi:10.1016 ... In 1959 Hazard et al. described medullary (solid) thyroid carcinoma. In 1961 Sipple described a combination of a ... Micrograph of a medullary thyroid carcinoma, as may be seen in MEN 2A and MEN 2B. H&E stain. ...
Uterine papillary serous carcinoma. *Endometrial intraepithelial neoplasia. *Uterine clear-cell carcinoma. Cervix. *Cervical ... Follicular cells flat epithelial cells that originate from surface epithelium covering the ovary, are surrounded by Granulosa ... Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica ...
In diagnostic immunohistochemistry, the expression of thyroid peroxidase (TPO) is lost in papillary thyroid carcinoma. Ruf J, ... Inorganic iodine enters the body primarily as iodide, I−. After entering the thyroid follicle (or thyroid follicular cell) via ... "Immunohistochemical loss of thyroid peroxidase in papillary thyroid carcinoma: strong suppression of peroxidase gene expression ...
Aggressive digital papillary adenocarcinoma (digital papillary adenocarcinoma, papillary adenoma) Apocrine gland carcinoma ... Basal cell carcinoma Basaloid follicular hamartoma Basaloid squamous cell carcinoma Birt-Hogg-Dubé syndrome Bowen's disease ( ... classic basal cell carcinoma) Paget's disease of the breast Papillary eccrine adenoma (tubular apocrine adenoma) Papillary ... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ...
DUOX2 Thyroid carcinoma, follicular; 188470; MINPP1 Thyroid carcinoma, follicular; 188470; NRAS Thyroid carcinoma, papillary; ... NCOA4 Thyroid carcinoma, papillary; 188550; PCM1 Thyroid carcinoma, papillary; 188550; PRKAR1A Thyroid carcinoma, papillary; ... OGG1 Renal cell carcinoma, papillary, 1; 605074; PRCC Renal cell carcinoma, papillary, 1; 605074; TFE3 Renal cell carcinoma, ... FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma; 144700; RNF139 Renal cell ...
There are two histological types of thyroid carcinoma arising from follicular cells, which are papillary carcinoma (PTC) and ... There are some important prognostic factors for papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). In ... are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas," ... Prognostic Factors of Papillary and Follicular Carcinomas in Japan Based on Data of Kuma Hospital. Yasuhiro Ito and Akira ...
REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary and Follicular Thyroid Carcinomas. The safety and ... Alternatively, follicular or papillary thyroid carcinoma patients with large distant tumor burdens which have not sufficiently ... Histological confirmation of follicular, papillary, insular, or Hürthle-cell thyroid carcinoma. Histologic slides and/or tissue ... Phase II Trial of REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary & Follicular Thyroid Carcinomas. ...
Alternatively, follicular or papillary thyroid. carcinoma patients with large distant tumor burdens which have not sufficiently ... papillary and follicular thyroid carcinomas, which no longer concentrate radioiodine, have. no known effective systemic ... Histological confirmation of follicular, papillary, insular, or Hürthle-cell thyroid. carcinoma. Histologic slides and/or ... Phase II Trial of REVLIMID® (Lenalidomide) for Therapy of Radioiodine-Unresponsive Papillary & Follicular Thyroid Carcinomas. ...
By the 1990s, it was claimed that RRA diminished recurrence rates in follicular cell-derived cancer (FCDC) patients and ... in the initial management of papillary and follicular thyroid cancer. ... Carcinoma, Papillary, Follicular / mortality * Carcinoma, Papillary, Follicular / pathology * Carcinoma, Papillary, Follicular ... in the initial management of papillary and follicular thyroid cancer. By the 1990s, it was claimed that RRA diminished ...
... read as suspicious by the Afirma molecular marker test were ultimately diagnosed as noninvasive follicular variant papillary ... a subgroup of papillary thyroid cancer called noninvasive follicular variant papillary thyroid cancer that has a very low risk ... Noninvasive follicular variant of papillary thyroid carcinoma and the Afirma gene-expression classifier. Thyroid 2016;26:911-5. ... Of the 16 cases of follicular variant papillary thyroid cancer, 14 of them were noninvasive follicular variant of papillary ...
Twenty patients with DTC (eight follicular, seven papillary, five oxyphilic) were selected for treatment with retinoic acid 1.5 ... Iodine uptake increased in eight patients (three follicular, three papillary, two oxyphilic). Thyroglobulin (TG) as parameter ... course of tumor progression the differentiated morphologic and functional characteristics of differentiated thyroid carcinomas ... Redifferentiation Therapy with Retinoids: Therapeutic Option for Advanced Follicular and Papillary Thyroid Carcinoma. @article{ ...
... and histological examination revealed follicular architecture with nuclear features of papillary carcinoma in 1 cm area of the ... We performed a fine needle aspiration (FNA), and the cytological examination suggested the possibility of thyroid carcinoma. ... Follicular variant of papillary thyroid carcinoma (FVPTC) presented as an autonomous functioning thyroid nodule is a rare ... Follicular variant of papillary thyroid carcinoma is found in 9-22.5% of patients with papillary thyroid carcinoma. It ...
For the rest of the talk Im really going to treat papillary and follicular carcinomas together as far as treatment decisions ... For the rest of the talk Im really going to treat papillary and follicular carcinomas together as far as treatment decisions ... and although it has traditionally been said that the outcome in follicular cancer is worse than the outcome in papillary cancer ... There have been several staging systems that have been popularized for papillary thyroid cancer. Its sort of one of these ...
From papillary thyroid cancer to follicular thyroid cancer, find out about the different types of cancer that can develop in ... Hurthle Cell Carcinoma. This is a rare form of follicular thyroid cancer. Some people refer to is as oxyphil cell carcinoma. It ... Follicular Thyroid Cancer. Fewer people have follicular thyroid cancer than papillary thyroid cancer. This type of thyroid ... The disease usually develops from a papillary thyroid cancer or follicular thyroid cancer thats in the body already. It ...
Papillary Carcinoma Follicular Variant Intermediate power image of papillary carcinoma, some micro acini are present. Note the ... Follicular_CA,_microfollicles_in_sheet_bx_proven,_DQ.jpg. Album name:. dkurtycz / Papillary Thyroid Carcinoma - Follicular ...
Follicular_neoplasm2,_low_power,_confirmed_FVPTC_DQ_SM.jpg. Album name:. dkurtycz / Papillary Thyroid Carcinoma - Follicular ...
Thyroid Papillary Carcinoma, Follicular Type. Wenig, Bruce M. Wenig, Bruce M. Less ... Exophytic and Papillary Squamous Cell Carcinoma of the Larynx. Kardon, David E.; Thompson, Lester D. R. ... Basaloid Squamous Cell Carcinoma: An Aggressive Variant of Squamous Cell Carcinoma of the Head and Neck Region. Wieneke, ... Cystic Squamous Cell Carcinomas of the Neck: Cytologic and Histologic Considerations. Ocal, Idris Tolgay; Suhrland, Mark J.; ...
... and follicular adenoma (FA) are histologically closely related tumors and differential diagnosis remains challenging. RNA ... Follicular variant of papillary thyroid carcinoma (FVPTC) and follicular adenoma (FA) are histologically closely related tumors ... Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas ... Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. Endocr Pathol. ...
BRAF mutation; C-PTC; FV-PTC; classic papillary thyroid carcinoma; follicular variant of papillary thyroid carcinoma ... The majority of papillary thyroid carcinoma (PTC) cases comprise classic papillary (C-PTC) and follicular variant (FV-PTC) ... Long-term outcomes of follicular variant vs classic papillary thyroid carcinoma.. Henke LE1, Pfeifer JD2, Baranski TJ3, DeWees ... Recurrence-free survival based on histologic sub-type of papillary thyroid carcinoma. ...
... dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid carcinomas.. ... in 47 thyroid carcinomas, including 10 paired normal/tumoral tissues. In carcinomas, variations of DUOX1 and DUOX2 mRNA levels ... Carcinoma, Papillary/genetics*. *Carcinoma, Papillary/metabolism*. *Carcinoma, Papillary, Follicular/genetics*. *Carcinoma, ...
Follicular thyroid carcinoma; Metastatic thyroid carcinoma; Molecular signatures of thyroid carcinoma; Papillary thyroid ... Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures.. Cracolici V1, Mujacic ... We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. ... To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, ...
Also termed papillary thyroid carcinoma (PTC). *Is a differentiated thyroid cancer meaning the cells may resemble normal ... Papillary cells resemble finger-like projections. *Tumor development can be related to radiation exposure, such as radiation ... Most common type of thyroid cancer: 70% to 80% of all thyroid cancers are papillary thyroid cancer ...
The skin metastasis of follicular variant of papillary carcinoma thyroid (FVPTC) is a rare condition and the lesions should be ... Occult Follicular Variant of Papillary Thyroid Carcinoma Presenting as Scalp Metastasis: A Case Report. ... Occult Follicular Variant of Papillary Thyroid Carcinoma Presenting as Scalp Metastasis: A ... cutaneous lesion may be the first evidence of disseminated malignancy in a patient with occult papillary thyroid carcinoma. ...
... follicular variant of papillary carcinoma and poorly differentiated carcinoma-as well as the problems raised by the newly ... It will address the differential diagnosis between follicular carcinoma and three tumor types-follicular adenoma, ... described categories of follicular tumors: follicular tumor of uncertain malignant potential, well-differentiated tumor of ... Follicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well- ...
Papillary and follicular thyroid carcinoma. N Engl J Med 1998;338:297-306. ... Papillary and follicular thyroid cancer: a selective approach to diagnosis and treatment. Annu Rev Med 1981;32:73-91. ... Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are the two most common thyroid cancers. They account for 90 ... Lin JD, Chao TC, Hsueh C. Follicular thyroid carcinomas with lung metastases: a 23-year retrospective study. Endocr J 2004;51: ...
... and the follicular (FTC) thyroid carcinomas which, following dedifferentiation, are assumed to give... ... Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas. ... Cohen Y, Xing M, Mambo E et al (2003) BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 95:625-627CrossRefPubMed ... A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas. Mol Cell Endocrinol 399: ...
Papillary carcinoma - radioiodine; Follicular carcinoma - radioiodine; I-131 therapy ...
... in papillary thyroid cancer (PTC) are poorly understood. We attempted to analyze the gene expression profile in PTC primary ... Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using ... BRAF Wild-Type Papillary Thyroid Carcinoma. J. Clin. Endocrinol. Metab. 2014, 99, E338-E347. [Google Scholar] [CrossRef] [ ... In our study, we undertook a step-by-step analysis to find differences between M0 and M1 papillary thyroid carcinomas. As ...
Attia D, Lurie A, Zhai Q, Smallridge R. Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF ... However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the ... Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations. In: BMJ case ... However, we report a 49-year-old woman who had aggressive follicular variant papillary thyroid carcinoma (FV-PTC) with both the ...
... ... The Molecular Profile Will More Accurately Indicate the Risk Of Malignancy Of the Thyroid Nodule Reported As a Follicular ... Frequently the Cytological Diagnosis is Reported As a Follicular Neoplasm. This Diagnosis Cannot Rule Out the Presence Of a ... Currently In the Market There is No Accepted Test That Will Improve Our Pre-operative Diagnostic Accuracy Of Follicular ...
Carcinoma. Thyroid Neoplasms. Thyroid Cancer, Papillary. Carcinoma, Medullary. Adenocarcinoma, Follicular. Thyroid Diseases. ... Genetic and Rare Diseases Information Center resources: Papillary Thyroid Carcinoma Thyroid Cancer, Follicular Thyroid Cancer, ... Stage IV Follicular Thyroid Cancer Stage IV Papillary Thyroid Cancer Thyroid Gland Medullary Carcinoma Drug: vorinostat Phase 2 ... Insular Thyroid Cancer Recurrent Thyroid Cancer Stage II Follicular Thyroid Cancer Stage II Papillary Thyroid Cancer ...
Papillary Thyroid Carcinoma Renal Cell Carcinoma Thyroid Cancer, Follicular Hurthle Cell Thyroid Cancer ... Papillary Thyroid Cancer Follicular Thyroid Cancer Huerthle Cell Thyroid Cancer Renal Cell Carcinoma Drug: rosiglitazone Drug: ... Carcinoma, Renal Cell. Thyroid Neoplasms. Thyroid Cancer, Papillary. Adenocarcinoma, Follicular. Thyroid Diseases. Endocrine ... Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Kidney Neoplasms. Urologic Neoplasms. ...
Follicular variant of papillary thyroid carcinoma is a variant of papillary thyroid carcinoma that has created continuous ... We concluded that follicular variant of papillary thyroid carcinoma differs from conventional papillary thyroid carcinoma in ... The aims of this study are to (1) investigate whether follicular variant of papillary thyroid carcinoma has a different pattern ... thyroid carcinoma in a large cohort of patients with typical features of follicular variant of papillary thyroid carcinoma and ...
Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular. December 18, 2018. Sherri Kuhn ... Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) will be the most ... of these are papillary thyroid carcinomas (PTC) [2]. The introduction of ultrasound exam to regular practice has found out a ... There is absolutely no proof vascular or capsular invasion in these neoplasms; normally, the lesion is known as carcinoma [3]. ...
We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal ... An Unusual Association between Sweets Syndrome and Metastatic Papillary Follicular Thyroid Carcinoma ... An Unusual Association between Sweets Syndrome and Metastatic Papillary Follicular Thyroi ... Adenocarcinoma, Follicular , Dermis , Exanthema , Fever , Hand , Humans , Immune System Diseases , Leukocyte Disorders , ...
  • Follicular variant of papillary thyroid carcinoma (FVPTC) and follicular adenoma (FA) are histologically closely related tumors and differential diagnosis remains challenging. (biomedcentral.com)
  • The skin metastasis of follicular variant of papillary carcinoma thyroid (FVPTC) is a rare condition and the lesions should be differentiated from primary skin tumors . (bvsalud.org)
  • Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer. (frontiersin.org)
  • Contrary to this HRAS T81C SNP of HRAS gene moderately increases thyroid cancer risk with rare allele as a predictive marker for follicular tumors. (springer.com)
  • Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor that was previously classified as an encapsulated follicular variant of papillary thyroid carcinoma, necessitating a new classification as it was recognized that encapsulated tumors without invasion have an indolent behavior, and may be over-treated if classified as a type of cancer. (wikipedia.org)
  • Although these tumors are also usually slow growing, they behave somewhat more aggressively than papillary carcinomas and are more likely to spread to the lungs or bones. (healthcentral.com)
  • Oncocytic adenomas and carcinomas are a subset of thyroid tumors predominantly composed (at least 75%) of oncocytic cells. (aacrjournals.org)
  • Tumors composed of oncocytic cells may occur at a variety of sites but are particularly common among thyroid tumors of follicular cell derivation ( 1 ). (aacrjournals.org)
  • Oncocytic thyroid tumors have long been suspected to be more aggressive than their non-oncocytic counterparts ( 1 ) and the presence of oncocytic features is now considered an adverse prognostic indicator for follicular thyroid carcinomas ( 2 ). (aacrjournals.org)
  • Thyroid cancer refers to any of four kinds of tumors of the thyroid gland which include papillary , follicular , medullary and anaplastic tumors . (wikidoc.org)
  • Papillary and follicular tumors are the most common and are usually benign . (wikidoc.org)
  • Papillary and follicular tumors have a slow growth and may recur, but are generally not fatal in patients under 45 years of age. (wikidoc.org)
  • Journal Article] Immunohistochemical Detection of NRASQ61R Protein in Follicular-patterned Thyroid Tumors. (nii.ac.jp)
  • 1] reported 5% of lymph node ''when defined with strict histopathologic criteria, these metastases and 1% of distant metastases in 102 patients tumors are not expected to show molecular alterations V600E with ''noninvasive follicular thyroid neoplasm with papil- associated with classic PTC, such as BRAF muta- lary-like nuclear features'' (NIFTP). (deepdyve.com)
  • Patients with a history of radiation administered in childhood for benign conditions of the head and neck have an increased risk of thyroid cancer, and inherited gene mutations are associated with certain medullary and papillary tumors. (vesalius.com)
  • Thyroid tumors are dominated by well-differentiated carcinomas, including papillary carcinoma, which makes up about 80% of thyroid cancers, and follicular carcinoma, which makes up about 10% of thyroid cancers. (vesalius.com)
  • Hurthle cell tumors are classified as a type of follicular carcinoma, representing about a quarter of the diagnoses in that category. (vesalius.com)
  • Papillary carcinoma has an 80-90% 10-year survival, and follicular tumors are associated with a 65-75% 10-year survival rate. (vesalius.com)
  • Insular thyroid cancer may also be seen variably in typical papillary or follicular thyroid tumors. (vesalius.com)
  • Papillary tumors metastasize usually through the lymph system, while follicular tumors travel through blood vessels. (vesalius.com)
  • The presence of vascular invasion is a poor prognostic factor in follicular tumors, and the prognosis for patients with distant metastasis usually to the lungs or bone is poor. (vesalius.com)
  • Recently, a proposal was made to reclassify this tumour type as a premalignant lesion and rename it non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). (cdc.gov)
  • Frequently the Cytological Diagnosis is Reported As a Follicular Neoplasm. (corfo.cl)
  • Follicular Neoplasm. (medhelp.org)
  • Has anyone had a follicular neoplasm which turned out to be cancer of the thyroid? (medhelp.org)
  • The other Univ of PA med center said follicular neoplasm with oncocytic features. (medhelp.org)
  • Definition of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): A noninvasive neoplasm that arises from the thyroid follicular cells (cells that normally make thyroid hormone), showing a predominantly follicular growth pattern and with nuclear features of papillary thyroid carcinoma. (wikipedia.org)
  • Abbreviations: NIFTP: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features EFVPTC: Encapsulated follicular variant of papillary thyroid carcinoma. (wikipedia.org)
  • Patients with follicular neoplasm, as determined with FNAB results, should undergo surgery for thyroid lobectomy for tissue diagnosis. (medscape.com)
  • FTC and other thyroid neoplasms arising from follicular cells (adenomas, papillary/follicular carcinoma, and noninvasive follicular thyroid neoplasm with papillary-like nuclear features [NIFTP]) show a broad range of overlapping clinical and cytologic features. (medscape.com)
  • If fine needle aspiration cytology (FNAC) suggests follicular neoplasm, thyroid lobectomy should be performed to establish the histopathological diagnosis. (wikipedia.org)
  • Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? (deepdyve.com)
  • Rosário, Pedro 2017-11-10 00:00:00 World J Surg (2018) 42:2277-2278 DOI 10.1007/s00268-017-4351-6 LETTE R T O T HE EDI T OR Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Did We Trade Six for a Half a Dozen? (deepdyve.com)
  • Approximately 90 percent of thyroid cancers arise from follicular cells (the cells that comprise most of the thyroid and make thyroid hormone). (rarediseases.org)
  • Well-differentiated cancers are made of cells that retain the look of the cells from which they arose (e.g., thyroid follicular cells). (rarediseases.org)
  • This rise has been predominantly driven by an increase in small papillary thyroid cancers, with mortality remaining largely unchanged. (gehealthcare.com)
  • 8 These small papillary thyroid cancers are increasingly being detected because of new technologies, increased access to health services, and thyroid cancer screening. (gehealthcare.com)
  • The most common type is papillary, comprising 70% to 80% of thyroid cancers. (aacrjournals.org)
  • Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. (genecards.org)
  • [ 9 ] In the United States, about 10-15% of all thyroid cancers are follicular. (medscape.com)
  • Medullary carcinoma is derived from parafollicular or C cells, whereas follicular cells give rise to several types of thyroid cancers. (news-medical.net)
  • The PAX8-PPARγ1 fusion is present in approximately one-third of follicular thyroid carcinomas, specifically those cancers with a t(2;3)(q13;p25) translocation, permitting juxtaposition of portions of both genes. (wikipedia.org)
  • About 90 percent of thyroid cancers develop from the follicular cells. (healthcentral.com)
  • Three percent of thyroid cancers are undifferentiated (anaplastic) carcinomas. (healthcentral.com)
  • Medullary carcinomas make up almost 5 percent of thyroid cancers. (healthcentral.com)
  • A number of factors affect the prognosis for papillary and follicular thyroid cancers. (healthcentral.com)
  • Follicular thyroid carcinoma comprises about 25% of all thyroid cancers, and its malignancy generally exceeds that of papillary carcinoma. (annals.org)
  • Papillary cancers are highly curable and rarely fatal. (southcoast.org)
  • Anaplastic carcinoma develops when papillary or follicular cancers mutate into a very aggressive form. (southcoast.org)
  • Papillary thyroid carcinoma (PTC) constitutes 70% of all thyroid cancers in the United States (Becker, 2001). (ndnr.com)
  • Follicular thyroid carcinoma (FTC) accounts for 5-10% of all thyroid cancers in the United States (Becker, 2001). (ndnr.com)
  • Medullary thyroid carcinoma (MTC) constitutes 10% of all thyroid cancers (Becker, 2001). (ndnr.com)
  • Poorly differentiated cancers, such as medullary and anaplastic carcinomas are much less common, each representing about 5% of thyroid malignancies. (vesalius.com)
  • Squamous cell carcinoma represents approximately 1% of all thyroid cancers, and often occurs in elderly men with history of thyroid gland enlargement (e.g., goiter). (vesalius.com)
  • Fine-needle aspiration does not effectively diagnose follicular-cell cancers because they require histologic demonstration of capsular or vascular invasion. (vesalius.com)
  • During the course of tumor progression the differentiated morphologic and functional characteristics of differentiated thyroid carcinomas (DTC) disappear. (semanticscholar.org)
  • The prognostic factors are similar for staging, and although it has traditionally been said that the outcome in follicular cancer is worse than the outcome in papillary cancer , oftentimes it's not clear if it relates to the difference in the tumor type or if it's more properly accounted for by these risk factors. (cancerstreatment.com)
  • Conclusion BRAF V600E was correlated with smaller tumor size and suspicious ultrasonographic features in follicular variant of PTC. (elsevier.com)
  • Comparison between thyroid tumor specimens and normal corresponding samples of 35 cancer patients demonstrated identical patterns, suggesting that the GST system is not involved in the process of follicular dedifferentiation. (aacrjournals.org)
  • Loh KC, Greenspan FS, Gee L, Miller TR, Yeo PP (1997) Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of 700 patients. (springer.com)
  • However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. (frontiersin.org)
  • Larger tumor size predicts nodal involvement in patients with follicular thyroid carcinoma. (nih.gov)
  • Given their resemblance to one of the variants of papillary thyroid carcinoma (which was excluded by both clinical and immunohistochemical means), such cases were referred to as 'breast tumor resembling the tall-cell variant of papillary thyroid carcinoma. (nature.com)
  • If this were the case, one might expect that such features need not be limited to cases of 'breast tumor resembling the tall-cell variant of papillary thyroid carcinoma', but may be common to papillary carcinomas of the breast in general. (nature.com)
  • The receptors' expression levels were variable in different tumor stage, molecular, and immune subtypes of renal carcinoma. (frontiersin.org)
  • Thyroglobulin (Tg) can be used as a tumor marker for well-differentiated follicular thyroid cancer. (wikipedia.org)
  • Features sine qua non for the diagnosis of follicular carcinoma are capsular invasion and vascular invasion by tumor cells. (wikipedia.org)
  • A better prognosis can be expected with a pure papillary carcinoma in younger patients (women under 50 and men under 40), a tumor smaller than 3/4 inch (2 cm.) small diffuse metastases, female sex, and low-grade lesions. (healthcentral.com)
  • A worse prognosis is related to age over 40, the degree of invasion (vascular and thyroid capsule) in follicular carcinoma, distant metastases, a large tumor (especially over 1 1/2 inch (5cm), large nodular metastases, male sex and high-grade lesions (aneuploid). (healthcentral.com)
  • Decreased survival in patients with oncocytic carcinomas may be due to reduced competence in iodine uptake by the tumor cells, resulting in poor response to radioiodine treatment ( 1 ). (aacrjournals.org)
  • Gross pathological section of a follicular thyroid carcinoma (tumor at the bottom). (bionity.com)
  • Our studies provide insight into the tumor type-specific mechanisms of antitumor effects of HDAC inhibitors and a framework for future clinical applications of HDAC inhibitors in patients with thyroid cancer, including histologic subtypes (e.g., anaplastic and medullary thyroid carcinomas) for which limited, if any, therapeutic options are available. (aacrjournals.org)
  • Soft-tissue involvement, tumor recurrence, and metastasis are more prevalent features of TCV compared with typical papillary carcinoma. (vesalius.com)
  • The incidence of regional nodal metastasis in thyroid cancer varies between 20-70%, depending on whether the tumor is papillary or follicular. (vesalius.com)
  • this happens a few atypical cells are seen but not enough to be abnormal (atypia of unknown significance (AUS) or follicular lesion of unknown significance (FLUS)) or when the diagnosis is a follicular or hurthle cell lesion. (thyroid.org)
  • Follicular and hurthle cells are normal cells found in the thyroid. (thyroid.org)
  • Current analysis of thyroid biopsy results cannot differentiate between follicular or hurthle cell cancer from noncancerous adenomas. (thyroid.org)
  • Reduced HBME1 immunoreactivity of papillary thyroid carcinoma and papillary thyroid carcinoma-related neoplastic lesions with Hurthle cell and/or apocrine-like changes. (thefreedictionary.com)
  • This includes the papillary or mixed follicular, follicular or hurthle cell, medullary and the anaplastic infections. (exclusivepapers.com)
  • Hurthle cell carcinoma should be considered a variant of FTC. (medscape.com)
  • Hurthle cell thyroid cancer is often considered a variant of follicular cell carcinoma. (wikipedia.org)
  • Hurthle cell forms are more likely than follicular carcinomas to be bilateral and multifocal and to metastasize to lymph nodes. (wikipedia.org)
  • In the test series the Hurthle cell line XTC, the follicular cell line HTC+, the anaplastic cell line and the cell line Hth74 as well as a cell line isolated from natural thyroid tissue (Thy1) were examined. (uni-marburg.de)
  • In addition, the aspirates showed many follicular cells with marked reactive changes as many Hurthle cells with large vesicular nuclei with prominent nucleoli and relatively abundant granular cytoplasm [ Figure 2 ]. (cytojournal.com)
  • Focally, some lymphoepithelial structures with Hurthle cells/thyroid follicular cells infiltrated by lymphocytes were present [ Figure 3 ]. (cytojournal.com)
  • 75% of follicular cells as oncocytes (Hurthle cells) with round nuclei showing prominent nucleoli, and abundant eosinophilic, granular cytoplasm, and without a significant amount of colloid. (cytojournal.com)
  • Hurthle cell carcinoma is a variant of follicular carcinoma, but it is harder to detect and treat. (southcoast.org)
  • See also medullary thyroid carcinoma and Hurthle cell thyroid cancer discussions. (vesalius.com)
  • Next generation sequencing showed BRAF V600E mutation in the primary papillary carcinoma and NRAS Q61R mutation in the primary follicular carcinoma and bony metastasis. (cdc.gov)
  • Occult Follicular Variant of Papillary Thyroid Carcinoma Presenting as Scalp Metastasis: A Case Report. (bvsalud.org)
  • In this report , we aim to present a case report of a 65 year -old female with scalp metastasis of FVPTC highlighting the fact that a solitary cutaneous lesion may be the first evidence of disseminated malignancy in a patient with occult papillary thyroid carcinoma . (bvsalud.org)
  • To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. (frontiersin.org)
  • In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. (frontiersin.org)
  • Factors predictive of lymph node metastasis in the follicular variant of papillary thyroid carcinoma. (nih.gov)
  • Accuracy of intraoperative determination of central node metastasis by the surgeon in papillary thyroid carcinoma. (nih.gov)
  • Experience and analysis of Delphian lymph node metastasis in patients with papillary thyroid carcinoma. (nih.gov)
  • Predictive factors for ipsilateral or contralateral central lymph node metastasis in unilateral papillary thyroid carcinoma. (nih.gov)
  • Factors related with metastasis of right retroesophageal lymph nodes in papillary thyroid cancer. (medscape.com)
  • Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma. (amedeo.com)
  • Metastasis to local lymph nodes does not worsen the prognosis of either of those carcinomas. (vesalius.com)
  • There are two histological types of thyroid carcinoma arising from follicular cells, which are papillary carcinoma (PTC) and follicular carcinoma (FTC). (hindawi.com)
  • Radioiodine remnant ablation (RRA) was developed in the 1960s to "complete a thyroidectomy" in the initial management of papillary and follicular thyroid cancer. (nih.gov)
  • One stage thyroidectomy and bilateral neck dissection for well-differentiated thyroid carcinoma]. (nih.gov)
  • Total thyroidectomy has been the mainstay for treating well-differentiated thyroid carcinoma. (medscape.com)
  • I had my total thyroidectomy about 12 years ago because I had a follicular nodule. (medhelp.org)
  • Current National Comprehensive Cancer Network (NCCN) guidelines recommend lobectomy plus isthmusectomy as the initial surgery for patients with follicular neoplasms, with prompt completion of thyroidectomy if invasive FTC is found on the final histologic section. (medscape.com)
  • Like follicular carcinoma, unilateral hemithyroidectomy is performed for non-invasive disease, and total thyroidectomy for invasive disease. (wikipedia.org)
  • If follicular cells are found on cytological testing, it is common to carry out hemithyroidectomy to distinguish between follicular adenoma and follicular carcinoma on histopathological examination, proceeding to completion thyroidectomy and postoperative radioiodine ablation where carcinoma is confirmed. (wikipedia.org)
  • The Molecular Profile Will More Accurately Indicate the Risk Of Malignancy Of the Thyroid Nodule Reported As a Follicular Neoplasms. (corfo.cl)
  • Currently In the Market There is No Accepted Test That Will Improve Our Pre-operative Diagnostic Accuracy Of Follicular Neoplasms. (corfo.cl)
  • Rare breast neoplasms resembling the tall-cell variant of papillary thyroid carcinoma have been reported. (nature.com)
  • Cytological examination helps to solve this issue more accurately but a cancer risk still exists in patients with a negative cytology, non-diagnostic or suspicious follicular neoplasms. (nih.gov)
  • It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. (wikipedia.org)
  • We report a case of synchronous papillary and follicular thyroid carcinomas metastatic to lymph node and bone, respectively. (cdc.gov)
  • We report for the first time a synchronous papillary and follicular thyroid carcinoma in a 12-year-old girl presenting with a large (5 cm diameter) left thyroid nodule, an increased left and right upper pole technetium tracer uptake at scintigraphy and hyperthyroidism. (biomedcentral.com)
  • Approximately just 5% of thyroid nodules are malignant [1] and 70% of these are papillary thyroid carcinomas (PTC) [2]. (cdkkinase.com)
  • There were 49 cases of benign and 67 cases of malignant nodules: 50 papillary and 17 follicular carcinomas. (aacrjournals.org)
  • Excluding lesions partly involving benign papillomas, malignant papillary lesions of the breast include papillary ductal carcinoma in situ , intracystic (encapsulated) papillary carcinoma, and solid papillary carcinoma, all of which may or may not be associated with unequivocal invasive carcinoma. (nature.com)
  • If the nuclear features in an encapsulated, non-invasive follicular patterned lesion fall short of those encountered in classical PTC, but nonetheless are still worrying or concerning, the term 'uncertain malignant potential or behaviour, most likely benign' is suggested. (bmj.com)
  • The diagnosis of encapsulated follicular-patterned thyroid carcinoma (EFPTC) is challenging, and the detection of capsular invasion and/or vascular invasion is essential in distinguishing benign lesions from malignant lesions. (springer.com)
  • Only 4 follicular adenomas (of 26) and 1 goiter (of 27) were positive for HBME1 on the TMA (5 of 80), whereas the corresponding whole section immunohistochemistry showed positive expression in 9 cases (1 of 8 FTCs, 4 of 26 adenomas, and 4 of 27 goiters). (thefreedictionary.com)
  • A study of differential gene expression profiling of aggressive and nonaggressive follicular carcinomas identified 94 genes that distinguish follicular carcinomas from follicular adenomas (including PBP and CKS2 ) and 4 genes that distinguish aggressive follicular carcinomas from nonaggressive follicular carcinomas ( NID2, TM7SF2, TRIM2, and GLTSCR2 ). (medscape.com)
  • and anaplastic carcinoma (AC): 8) and 152 follicular adenomas (FAs). (mdpi.com)
  • Thyroid nodules may be adenomas or carcinomas. (wellspan.org)
  • benign), 25% of cases had follicular variant papillary thyroid cancer, 2% of cases had classical papillary thyroid cancer and 8% of cases had follicular thyroid cancer. (thyroid.org)
  • Five sections comprise this atlas, including the normal thyroid, diffuse thyroid lesions, both benign and malicious lesions (including various carcinomas), and rare findings. (google.co.uk)
  • Among the 356 cases with benign nodular lesions, 99 cases of papillary carcinoma were found in the thyroid parenchyma. (nih.gov)
  • Clinical safety of renaming encapsulated follicular variant of papillary thyroid carcinoma: is NIFTP truly benign? (deepdyve.com)
  • 1. Intro Solitary and multiple nodules from the thyroid gland have become common in medical practice, with many of them becoming harmless lesions, either thyroid nodular hyperplasia (TNH) or follicular thyroid adenoma (FTA). (cdkkinase.com)
  • At present, the " in diebus illis " of the pathologist resides in the differential diagnosis of encapsulated lesions with some of the aforementioned nuclear characteristics and a follicular pattern of growth. (scielo.br)
  • Follicular patterned lesions of the thyroid are problematic and interpretation is often subjective. (bmj.com)
  • Papillary carcinomas spread to nearby lymph nodes and the tissues in the neck, with metastatic lesions to the lungs and bones. (healthcentral.com)
  • This modified gross examination method might allow a better differential diagnosis among various encapsulated micro-follicular proliferative lesions. (springer.com)
  • There are some important prognostic factors for papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC). (hindawi.com)
  • These two histological types are also called differentiated carcinoma (DTC) and analyzed as a single group for clinical studies investigating prognostic factors and prognosis of patients. (hindawi.com)
  • Dean DS, Hay ID (2000) Prognostic indicators in differentiated thyroid carcinoma. (springer.com)
  • Gilliland FD, Hunt WC, Morris DM, Key CR (1997) Prognostic factors for thyroid carcinoma. (springer.com)
  • Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. (springer.com)
  • Ito Y, Miyauchi A. Prognostic factors and therapeutic strategies for differentiated carcinoma of the thyroid. (springer.com)
  • Papillary thyroid carcinoma (PTC), medullary thyroid carcinoma (MTC), follicular thyroid carcinoma (FTC), and ana-plastic thyroid carcinoma (ATC) are the four main types of thyroid carcinoma ( 4 ). (frontiersin.org)
  • Molecular genotyping of the non-invasive encapsulated follicular variant of papillary thyroid carcinoma. (cdc.gov)
  • The non-invasive encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) has been managed as a low-risk malignancy. (cdc.gov)
  • Capsular and vascular invasion remain the only reliable predictors of outcome, as non-invasive, encapsulated follicular variant PTC, even with diffuse PTC nuclear change, behaves in an indolent fashion. (bmj.com)
  • The diagnostic rate of follicular thyroid carcinoma and invasive encapsulated follicular variant of papillary thyroid carcinoma was higher with the modified method ( p = 0.003 and p = 0.028, respectively). (springer.com)
  • His rant about the reclassification of a non-encapsulated follicular variant of papillary thyroid cancer as not cancer is more of the same, as you will see. (scienceblogs.com)
  • These findings have shown that patients with low-risk thyroid cancer, the most common type being the noninvasive encapsulated follicular variant of papillary thyroid carcinoma (EnFvPTC), are usually at decreased risk of adverse outcome, this pointing to the need for less aggressive treatment in these subjects. (springer.com)
  • Finally, pathologists have expanded the types of nodules that are diagnosed as carcinomas, and this is an area of controversy in thyroid pathology. (news-medical.net)
  • Disease free of other prior malignancies for ≥ 5 years, with the exception of currently treated basal cell/squamous cell carcinoma of the skin or "in-situ" carcinoma of the cervix or breast. (knowcancer.com)
  • Rare forms of thyroid cancer include thyroid teratoma, lymphoma, and squamous cell carcinoma. (rarediseases.org)
  • Rare and unusual forms of thyroid cancer include the tall cell variant (TCV) form of papillary carcinoma, insular thyroid cancer, squamous cell carcinoma, and thyroid lymphoma. (vesalius.com)
  • After the Pathology test I was diagnosed with PAPILLARY CARCINOMA cancer. (cancer.org)
  • Inclusion criteria were detailed case descriptions of children aged below 16 years old with a clinical and biological hyperthyroidism and an underlying differentiated thyroid carcinoma documented at histological examination. (biomedcentral.com)
  • By histological stratification analyis, we observed that the association between the presence of heterozygozity in the MUTYH Gln335His polymorphism and TC risk almost reached significance for the papillary subtype of TC. (spandidos-publications.com)
  • Papillary and follicular thyroid carcinomas are the most common histological varieties, with papillary TC representing about 85% of all cases. (spandidos-publications.com)
  • Thyroid carcinoma (TC) is the most frequent endocrine malignancy, accounting for approximately 3.8% of all newly diagnosed cancer ( 1 ). (frontiersin.org)
  • Thyroid carcinomas are the most frequent malignancy of endocrine organs. (uni-marburg.de)
  • To our knowledge, this is the first reported case of synchronous and metastatic primary papillary and follicular carcinomas, and the first report of synchronous BRAF V600E mutated papillary and NRAS mutated follicular carcinoma. (cdc.gov)
  • Methods Eighty-four patients with pathologically confirmed follicular variant of PTC, who underwent a preoperative BRAF V600E study, were analyzed. (elsevier.com)
  • BRAF V600E was a significant parameter for predicting multifocality of follicular variant of PTC. (elsevier.com)
  • Frasca F, Nucera C, Pellegriti G, Gangemi P, Attard M, Stella M et al (2008) BRAF(V600E) mutation and the biology of papillary thyroid cancer. (springer.com)
  • In this study, we evaluated 33 intraductal/intracystic papillary carcinomas of the breast for the presence and extent of nuclear overlap, grooves, clearing, and inclusions, as well as features of the tall-cell or columnar-cell variants of papillary thyroid carcinoma. (nature.com)
  • The aim of this study was to find out how often indeterminate thyroid biopsy specimens which were read as "suspicious" by the GEC test were ultimately diagnosed as noninvasive follicular variant papillary thyroid cancer after surgery. (thyroid.org)
  • The authors concluded that a GEC suspicious test result may include noninvasive follicular variant papillary thyroid cancer as well as classical papillary thyroid cancer. (thyroid.org)
  • An important limitation of this study is that the authors did not examine the rate of noninvasive follicular variant papillary thyroid cancer in specimens that were not reported as suspicious by the GEC test. (thyroid.org)
  • One local one said highly suspicious for papillary carcinoma. (medhelp.org)
  • Although papillary carcinomas of breast often display one or more cytoarchitectural features of papillary thyroid carcinoma, there is no evidence that RET rearrangements are involved. (nature.com)
  • Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. (scielo.br)
  • These figures, together with the fact that some cases of conventional PTC have an aggressive behaviour and may even progress to anaplastic thyroid carcinoma (ATC) (5,6), highlight the need of more powerful indicators for diagnosis and prognosis in PTC. (scielo.br)
  • This study suggests that more research is needed to determine if the noninvasive follicular variant thyroid cancer can be diagnosed by molecular markers without proceeding to surgery. (thyroid.org)
  • Synchronous and Metastatic Papillary and Follicular Thyroid Carcinomas with Unique Molecular Signatures. (cdc.gov)
  • Molecular genetics of papillary thyroid carcinoma: great expectations. (scielo.br)
  • Genética molecular do carcinoma papilífero de tireóide grandes esperanças. (scielo.br)
  • Thus, follicular thyroid carcinomas seem to arise by two distinct and virtually nonoverlapping molecular pathways. (wikipedia.org)
  • Surgical extent of central lymph node dissection in clinically node-negative papillary thyroid cancer. (nih.gov)
  • Lymph node dissection in non-medullary differentiated thyroid carcinoma]. (nih.gov)
  • Despite the generally favourable prognosis of patients with papillary microcarcinomas, "cancer-related mortality rates may be as high as 1.0%, the rate of distant metastases as high as 2.5%, and rates of lymph node recurrence as high as 5%" (3,4). (scielo.br)
  • Autopsy studies show a large reservoir of undetected papillary thyroid cancer that never causes harm, 7 and the incidence of thyroid cancer has risen substantially in many developed countries. (gehealthcare.com)
  • Production of thyroid hormones is almost exclusively associated with the follicular histologic type. (annals.org)
  • It is impossible to distinguish between follicular adenoma and carcinoma on cytological grounds. (wikipedia.org)
  • Papillary thyroid cancer is the most common type of thyroid cancer. (thyroid.org)
  • This type of thyroid cancer is sometimes called undifferentiated carcinoma . (mskcc.org)
  • In the 1980s, a pathological entity of poorly differentiated carcinoma (PDC) was proposed by Sakamoto et al. (hindawi.com)
  • Representative images showing collagen XXIII staining in the NSCLC subtypes: (A) lung adenocarcinoma, (B) large cell carcinoma, and (C) SqCC. (aacrjournals.org)
  • Together, papillary carcinoma and follicular carcinoma are called differentiated thyroid cancer. (cancer.ca)
  • Done in cases of papillary or follicular carcinoma of thyroid, medullary carcinoma of thyroid. (wikipedia.org)
  • We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal pharyngitis . (bvsalud.org)
  • To assess the bioenergetic efficiency of mitochondria, we analyzed the thyroid oncocytic follicular cell line XTC.UC1 and compared it with other non-oncocytic lines of follicular cell derivation. (aacrjournals.org)
  • Contribution of immunocytochemical stainings for galectin-3, CD44, and HBME1 to fine-needle aspiration cytology diagnosis of papillary thyroid carcinoma. (thefreedictionary.com)
  • Likewise, for both low risk ductal carcinoma in situ (DCIS) and localised prostate cancer, detection strategies have become controversial as long term outcomes for both conditions have been shown to be excellent 11 12 and there is evidence and concern about overdiagnosis and overtreament. (gehealthcare.com)
  • For example, as a breast cancer surgeon, I deal all the time with a disease entity known as ductal carcinoma in situ (DCIS). (scienceblogs.com)
  • 6 A prime example is low risk papillary thyroid cancer. (gehealthcare.com)
  • Adjuvant radioactive iodine therapy is associated with improved survival for patients with intermediate risk papillary thyroid cancer. (medscape.com)
  • Therefore, the diagnosis of NIFTP, like that of follicular adenoma, may require surgical resection and exclusion of those tumours with any papillae. (cdc.gov)
  • Ali, Syed Z. / Cytological diagnosis of follicular variant of papillary thyroid carcinoma before and after the bethesda system for reporting thyroid cytopathology . (elsevier.com)
  • The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. (intechopen.com)
  • Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. (thefreedictionary.com)
  • The results of selective use of radioactive iodine on survival and on recurrence in the management of papillary thyroid cancer, based on memorial sloan-kettering cancer center risk group stratification. (medscape.com)
  • As the thyroid cancer can uptake iodine , radioactive iodine is commonly used for the treatment of thyroid carcinomas. (wikidoc.org)
  • Ten years have now elapsed since the first patient with carcinoma of the thyroid was treated with radioactive iodine. (annals.org)
  • 1 More than 250 thyroid carcinoma patients have been treated since then with radioactive iodine, I 131 . (annals.org)
  • Generally, PTC and FTC are indolent diseases and show good prognoses of patients, but when the lesion dedifferentiates, becoming undifferentiated carcinoma (anaplastic carcinoma), the prognosis of patients turned to be extremely poor. (hindawi.com)
  • normally, the lesion is known as carcinoma [3]. (cdkkinase.com)
  • The purpose of this review is to highlight the importance of proper diligent sampling of an encapsulated thyroid lesion (in totality in many cases), examination for capsular and vascular invasion, and finally the assessment of nuclear changes that are pathognomonic of papillary thyroid carcinoma (PTC). (bmj.com)
  • By the 1990s, it was claimed that RRA diminished recurrence rates in follicular cell-derived cancer (FCDC) patients and decreased the cause-specific mortality (CSM) in patients more than 40 years old at initial surgery. (nih.gov)
  • A group of expert pathologists have recently identified a subgroup of papillary thyroid cancer called noninvasive follicular variant papillary thyroid cancer that has a very low risk of relapsing after surgical removal. (thyroid.org)
  • Cervical node metastases in papillary thyroid cancer certainly are not a terrible risk factor, and in fact many studies would suggest that there is little difference in outcome related to the presence or absence of cervical nodes, but there may be some factor. (cancerstreatment.com)
  • Most of the deaths from papillary thyroid cancer, from differentiated thyroid cancer, occur in patients who acquire the disease at an older age. (cancerstreatment.com)
  • There have been several staging systems that have been popularized for papillary thyroid cancer . (cancerstreatment.com)
  • You'll notice that for differentiated follicular cancer, for patients less than 45, the only differentiating factor is the presence of absence of metastases. (cancerstreatment.com)
  • Most people with thyroid cancer have papillary thyroid cancer. (mskcc.org)
  • Fewer people have follicular thyroid cancer than papillary thyroid cancer. (mskcc.org)
  • The disease usually develops from a papillary thyroid cancer or follicular thyroid cancer that's in the body already. (mskcc.org)
  • Despite the relatively high prevalence of thyroid cancer, the occurrence of multiple synchronous, distinct subtypes of primary thyroid carcinoma is uncommon. (cdc.gov)
  • Initial enrollment will be limited to differentiated thyroid cancer and renal cell carcinoma. (clinicaltrials.gov)
  • Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, Rhoden KJ et al (2005) BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. (springer.com)
  • Thyroid cancer (carcinoma) is cancer affecting the thyroid gland, a butterfly-shaped structure located at the base of the neck. (rarediseases.org)
  • The four main types of thyroid cancer are papillary, follicular, medullary and anaplastic. (rarediseases.org)
  • Papillary cancer is by far the most common, comprising about 80% of all thyroid cancer. (rarediseases.org)
  • Well-differentiated thyroid cancer usually refers to papillary or follicular forms of thyroid cancer. (rarediseases.org)
  • Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. (springer.com)
  • High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. (springer.com)
  • Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer. (springer.com)
  • Papillary thyroid cancer is often described as the "good cancer" because of its treatability and relatively favorable survival rates. (bioportfolio.com)
  • We sought to characterize the thoughts of papillary thyroid cancer. (bioportfolio.com)
  • 4 Studies show that rates of metastases, progression to clinical disease, and tumour growth in patients with small papillary thyroid cancer who receive immediate surgery are comparable with those in patients who follow active surveillance. (gehealthcare.com)
  • A multicenter, open-label, phase II trial was conducted to evaluate the efficacy, safety, and tolerability of selumetinib in iodine-refractory papillary thyroid cancer (IRPTC). (aacrjournals.org)
  • Patients with iodine-refractory papillary thyroid cancer (IRPTC) have few therapeutic options, and there is currently no consensus standard of care for patients in this setting. (aacrjournals.org)
  • The prognosis is extremely good for papillary thyroid cancer (PTC) with overall 10-year survival rates of 98% ( 1-3 ). (aacrjournals.org)
  • Mutations in this gene have been identified in human papillary thyroid carcinoma (PTC) patients that abrogate the ability of encoded lncRNA to inhibit cancer cell growth. (genecards.org)
  • Busko M. Study supports selective RAI use in papillary thyroid cancer. (medscape.com)
  • Seventy-nine of the 99 cases were clinical cancer and were found preoperatively by cytology, while 20 out of 277 (7.22%) cases were found postoperatively as incidental carcinoma. (nih.gov)
  • Papillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. (scielo.br)
  • Follicular thyroid carcinoma (FTC) is the second most common cancer of the thyroid, after papillary carcinoma . (medscape.com)
  • Patients with FTC are more likely to develop lung and bone metastases than are patients with papillary thyroid cancer. (medscape.com)
  • Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50 years of age. (wikipedia.org)
  • Mutations in MINPP1 have likewise been observed, as well as germline PTEN gene mutations responsible for Cowden syndrome of which follicular thyroid cancer is a feature. (wikipedia.org)
  • By overall cancer staging into stages I to IV, follicular thyroid cancer has a 5-year survival rate of 100% for stages I and II, 71% for stage III, and 50% for stage IV. (wikipedia.org)
  • An important factor of cancer progression was recognized in the capacity of thyroid carcinoma cells to angiogenesis, procuring them an unlimited growth and the invasion of the surrounding tissue. (uni-marburg.de)
  • For more information on papillary thyroid cancer causes , click here . (wikidoc.org)
  • Follicular thyroid cancer is a form of thyroid cancer which occurs more commonly in women of over 50 years old. (bionity.com)
  • Differentiated thyroid cancer (papillary and follicular carcinomas), anaplastic carcinoma and medullary carcinoma each have their own staging. (cancer.ca)
  • Albores-Saavedra J, Henson DE, Glazer E, Schwartz AM. Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype-papillary, follicular and anaplastic: a morphological and epidemiological study. (springer.com)
  • Radiomics in predicting mutation status for thyroid cancer: A preliminary study using radiomics features for predicting BRAFV600E mutations in papillary thyroid carcinoma. (amedeo.com)
  • Thyroid carcinoma in children, adolescents, and young adults in Brazil: A report from 11 population-based cancer registries. (amedeo.com)
  • It is generally highest in papillary cancer the most common form. (vesalius.com)
  • Distantly metastatic, unresectable medullary thyroid carcinomas, as well as de-differentiated papillary and follicular thyroid carcinomas, which no longer concentrate radioiodine, have no known effective systemic therapies. (knowcancer.com)
  • Pathological definition and clinical significance of vascular invasion in thyroid carcinomas of follicular epithelial derivation. (springer.com)
  • Expression of nicotinamide adenine dinucleotide phosphate oxidase flavoprotein DUOX genes and proteins in human papillary and follicular thyroid ca. (nih.gov)
  • Initially, we examined 1387 cases (624 follicular adenoma, 399 FTC, 203 non-invasive encapsulated FV-PTC/NIFTP, and 161 invasive encapsulated FV-PTC cases), which were diagnosed as EFPTN after thyroid surgery at Asan Medical Center from 2013 to 2014 by conventional transverse gross examination and from 2016 to 2017 by modified transverse-vertical gross examination (Supp. (springer.com)