Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Salivary Glands, Minor: Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Adenolymphoma: A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.Mucoepidermoid Tumor: A malignant epithelial tumor of glandular tissue, especially the salivary glands, characterized by acini with mucus-producing cells and by the presence of malignant squamous elements. Most mucoepidermoid tumors are low-grade lesions readily cured by adequate excision. They may appear in any age group. They grow slowly. If high-grade, they behave aggressively, widely infiltrating the salivary gland and producing lymph node and distant metastases. (Dorland, 27th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Tracheal NeoplasmsAdenoma, Pleomorphic: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Cystadenoma, Papillary: A benign neoplasm of the ovary.Maxillary Neoplasms: Cancer or tumors of the MAXILLA or upper jaw.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Palatal Neoplasms: Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.Jaw Cysts: Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.Sublingual Gland Neoplasms: Neoplasms of the sublingual glands.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Mandibular Neoplasms: Tumors or cancer of the MANDIBLE.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Lacrimal Apparatus Diseases: Diseases of the lacrimal apparatus.Gene Fusion: The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. ARTIFICIAL GENE FUSION is carried out in vitro by RECOMBINANT DNA technology.Maxillary Sinus: The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.Radiography, Panoramic: Extraoral body-section radiography depicting an entire maxilla, or both maxilla and mandible, on a single film.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Lung Neoplasms: Tumors or cancer of the LUNG.Liver Neoplasms: Tumors or cancer of the LIVER.Mouth Neoplasms: Tumors or cancer of the MOUTH.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Oncogene Proteins, Fusion: The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Mucus: The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).BooksScrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.Sublingual Gland: A salivary gland on each side of the mouth below the TONGUE.Parotid Gland: The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Pathology, Clinical: A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.

Regulation of human airway mucins by acrolein and inflammatory mediators. (1/163)

Bronchitis, asthma, and cystic fibrosis, marked by inflammation and mucus hypersecretion, can be caused or exacerbated by airway pathogens or irritants including acrolein, an aldehyde present in tobacco smoke. To determine whether acrolein and inflammatory mediators alter mucin gene expression, steady-state mRNA levels of two airway mucins, MUC5AC and MUC5B, were measured (by RT-PCR) in human lung carcinoma cells (NCI-H292). MUC5AC mRNA levels increased after >/=0.01 nM acrolein, 10 microM prostaglandin E2 or 15-hydroxyeicosatetraenoic acid, 1.0 nM tumor necrosis factor-alpha (TNF-alpha), or 10 nM phorbol 12-myristate 13-acetate (a protein kinase C activator). In contrast, MUC5B mRNA levels, although easily detected, were unaffected by these agonists, suggesting that irritants and associated inflammatory mediators increase mucin biosynthesis by inducing MUC5AC message levels, whereas MUC5B is constitutively expressed. When transcription was inhibited, TNF-alpha exposure increased MUC5AC message half-life compared with control level, suggesting that transcript stabilization is a major mechanism controlling increased MUC5AC message levels. Together, these findings imply that irritants like acrolein can directly and indirectly (via inflammatory mediators) increase airway mucin transcripts in epithelial cells.  (+info)

Sclerosing Mucoepidermoid carcinoma with eosinophilia of the thyroid glands: a case report with clinical manifestation of recurrent neck mass. (2/163)

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a recently recognized malignant neoplasm of the thyroid gland. About 14 cases of SMECE have been reported and this is the first reported case in Korea. A 57-year-old woman presented with right neck mass for 20 years. Total thyroidectomy was performed under the impression of thyroid carcinoma. The resected thyroid gland showed a poorly circumscribed hard mass. Histologically, the tumor consisted of solid nests of large atypical cells with dense fibrous stroma. The tumor cells showed squamoid appearance with abundant eosinophilic cytoplasm. There were also rare mucin-containing cells within the nests. Within the hyalinized stroma, numerous eosinophils were found. The surrounding thyroid parenchyma displayed Hashimoto's thyroiditis. There was metastasis in a regional lymph node. Two years after initial surgery, she underwent a modified radical neck dissection due to recurrent neck mass. After the radiation therapy for eight weeks, laryngectomy and esophagectomy were performed due to a recurrent carcinoma in the esophageal wall. We report an additional case of SMECE, with metastasis to regional lymph nodes and esophagus. The tumor appears to be more aggressive than previously reported and a correct diagnosis can be rendered by just examining the metastatic lesions.  (+info)

Characterization of CFTR expression in a human pulmonary mucoepidermoid carcinoma cell line, NCI-H292 cells. (3/163)

The NCI-H292 cell, a human pulmonary mucoepidermoid carcinoma cell line, is commonly used for studying bacterial and viral infections of airway epithelial cells. Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) is the main cause of fetal lung infection in cystic fibrosis patients. In this study, we examined CFTR expression in NCI-H292 cells to determine whether NCI-H292 cells possess sufficient, normally functioning CFTR. The results of RT-PCR and Northern blotting analysis indicated that the CFTR gene expression level was much lower in NCI-H292 cells than in T84 cells. However, Western blotting analysis showed that protein expression in NCI-H292 cells was comparable to that in T84 cells. Furthermore, whole-cell and cell-attached patch clamp electrophysiological techniques indicated that the Cl- current induced by intracellular cAMP elevation in NCI-H292 cells was comparable to that in T84 cells. These findings suggest that NCI-H292 cells with a low level of CFTR gene expression possess enough functional CFTR to show a physiological response.  (+info)

Salivary gland tumors in Jordan: a retrospective study of 221 patients. (4/163)

AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries.  (+info)

Detection of circulating anti-p53 antibodies in esophageal cancer patients. (5/163)

It has been reported that circulating anti-p53 antibodies (p53-Ab) in the serum are detected in some cancers. To investigate the usefulness of detecting p53-Ab, we measured the circulating p53-Ab in comparison with squamous cell carcinoma antigen (SCC-Ag) in patients with esophageal carcinoma. Serum specimens from 46 esophageal cancer patients (42 squamous cell carcinomas, 3 mucoepidermoid carcinomas and 1 basaloid squamous carcinoma) and 13 healthy subjects were studied. Serum p53-Ab was measured by an enzyme-linked immunosorbent assay. Surgically resected specimens from 43 patients were immunohistochemically stained for p53. Serum SCC-Ag was measured by a radioimmunoassay. The results were analyzed with the clinical data and outcome. Serum p53-Ab was detected in 13 (28%) of the 46 patients, but not in any of the healthy subjects. The positive rate was 0% (0/6) in stage I, 60% (3/5) in stage IIA, 30% (3/10) in stage IIB, 29% (7/24) in stage III and 0% (0/1) in stage IV. There was no difference in the outcome between the p53-Ab-positive and p53-Ab-negative patients. Immunohistochemically, 30 (70%) of the 43 specimens stained positively for p53. Serum p53-Ab was detected in 43% (13/30) of the patients with tumors which stained positively for p53. There was a close correlation between positivity for p53 immunostaining and positivity for p53-Ab (p<0.01). An elevated level of SCC-Ag was found in only 13%of the patients, and most patients positive for SCC-Ag already had advanced disease with lymph node metastasis and invasion to the adventitia. In conclusion, serum p53-Ab was detected in Japanese esophageal cancer patients at a frequency similar to that reported in Western countries. Serum p53-Ab may be a potentially useful molecular marker for detection and screening of esophageal cancer. Further studies of a large population may be required to elucidate the true diagnostic usefulness of measuring the serum p53-Ab.  (+info)

Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study. (6/163)

OBJECTIVES: To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. MAIN OUTCOME MEASURES: Demographic data, cancer T- and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. RESULTS: Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. CONCLUSIONS: The N-stage is the main prognostic factor of overall survival, relapse- and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.  (+info)

Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands. (7/163)

CONTEXT: Among the cytological and morphological properties of mucoepidermoid carcinoma, one of the most important criteria for measuring its biological behavior and aggressiveness is cell proliferation. In this way, immunohistochemical markers of cell proliferation have been found to be useful in tumor classification and have formed part of the prognostic and therapeutic studies of these pathologies. OBJECTIVE: To analyze 11 cases of mucoepidermoid carcinoma (MEC) using the proliferation activity marker (PCNA) and to determine its relationship to the grade of malignancy of these tumors. DESIGN: Correlation study. SETTING: Head and Neck Surgery Service of Heliopolis Hospital, Sao Paulo, Brazil. SAMPLE: Slides of 11 cases of primary mucoepidermoid carcinomas of salivary glands were prepared according to routine techniques employed in the Oral Pathology Department of the Dentistry Faculty of Sao Paulo University, Brazil. They were fixed in a 10% formaldehyde solution and stained with hematoxylin and eosin. After this preparation the tumors were classified as low, intermediate and high grade of malignancy, according to the criteria established by Seifert & Sobin and Auclair, Goode & Ellis. The slides were sent for immunohistochemical processing to evaluate the positivity of proliferating cell nuclear antigen using the streptavidin biotin technique. MAIN MEASUREMENT: The correlation between proliferating cell nuclear antigen expression and the histological malignancy grade in mucoepidermoid carcinoma of salivary glands. RESULTS: there were 4 cases (36%) of low grade, 4 cases (36%) of intermediate grade and 3 cases (27%) of high grade of malignancy. After a comparative study between histological features and immunohistochemical analysis, significant differences were observed (P < 0.01) for low, intermediate and high grades: 16.04%, 26.98% and 56.98% of proliferating cell nuclear antigen expression in mucoepidermoid carcinoma, respectively. CONCLUSION: The proliferating cell nuclear antigen expression increases with the grade of malignancy in mucoepidermoid carcinoma of salivary glands.  (+info)

Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. (8/163)

Mucoepidermoid carcinoma is a rare primary thyroid tumor with indolent biologic potential. Two types of tumors have been described under this category: mucoepidermoid carcinoma (MEC) and sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE). The MEC shows both squamous and glandular differentiation in a background of a noninflamed gland, whereas SMECE is characterized by extensive sclerosis, squamous and glandular differentiation, a concomitant inflammatory infiltrate rich in eosinophils, and a background of lymphocytic thyroiditis. We present nine cases of these entities: five MEC and four SMECE. All tumors occurred in women (age 27 to 73 years). Five tumors showed extrathyroidal invasion and multiple lymph node metastases. One case of MEC showed a concomitant tall cell variant of papillary carcinoma with vascular invasion, and two cases showed intimately associated areas of usual papillary carcinoma. One of the latter cases also showed areas of transformation to anaplastic carcinoma. In all cases of SMECE and in only one case of MEC, the uninvolved thyroid tissue showed lymphocytic thyroiditis. Follow-up information was available in four of the nine cases (3 months to 7 years). Two patients with SMECE are alive with no evidence of disease. One patient with MEC and tall cell variant of papillary carcinoma died of disease after 3 months, and the patient with anaplastic carcinoma died after 5 months with lung metastasis. Both MEC and SMECE were positive for cytokeratin and negative for calcitonin. All cases of MEC were positive for thyroglobulin, whereas all cases of SMECE were negative. The immunohistochemical findings suggest that both MEC and SMECE have different histogenesis.  (+info)

TY - JOUR. T1 - Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. AU - Roden, Anja. AU - García, Joaquín J.. AU - Wehrs, Rebecca N.. AU - Colby, Thomas V.. AU - Khoor, Andras. AU - Leslie, Kevin O.. AU - Chen, Longwen. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. t(11;19)(q21;p13) is considered disease-defining for mucoepidermoid carcinoma; its significance in pulmonary mucoepidermoid carcinoma warrants further study. Forty three pulmonary mucoepidermoid carcinomas were re-reviewed and graded according to the Brandwein grading system for mucoepidermoid carcinoma. Four cases were excluded because of a split ...
TY - JOUR. T1 - Oncocytic variant of mucoepidermoid carcinoma of submandibular gland. T2 - An unusual clinical and morphological entity. AU - Krishnanand, Geetha. AU - Kaur, Manpreet. AU - Rao, Ravikala V.. AU - Monappa, Vidya. PY - 2007/7/1. Y1 - 2007/7/1. N2 - In this case report we describe a rare tumor - Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature. Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms, which include oncocytoma, Warthins tumor, and the rare, oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland. To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland. The recognition of this ...
Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node metastasis, and I ...
Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac and thyroid. Mucicarmine staining is one stain used by pathologist for detection. Occurs in adults, with peak incidence from 20-40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research. Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors. This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells. Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749. A possible ...
Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been reported in Brazilian populations. Aim: To report clinical and pathologic data from 173 head and neck MEC treated in the Treatment and Research Center at Hospital do Câncer A. C. Camargo in São Paulo. Study design: Clinical randomized. Material and Method: From 1953 to 1997, 173 cases of MEC were found in the medical files of the center. Data were obtained from the patients records and histological review of all cases. Results: The mean age of the patients was 44 years and 93 (53.8%) were men; parotid glands were affected in 61 cases (35.2%) and intraoral minor salivary glands in 75 (43.4%). TNM revealed 50.3% of the cases in stages I and II, and histological grading revealed 45.2%, 18.5% and 36.3% low-grade, intermediate-grade and high-grade tumors, respectively. Surgical treatment was employed in 80.3% of the cases, with neck dissection in 52 cases (30.1%), and ...
Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis.
Objective. It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.. Methods. This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005. The relationship between clinical and pathologic characteristics and survival rate was investigated.. Results. The 5-year overall and disease-free survival rate was 62.3 and 57.2%. Multivariate analysis demonstrated that the parameters that significantly affected survival were the patients age (P = 0.040) and treatment method (P = 0.011).. Conclusions. The patients age and treatment method is the prognostic parameter in this study. Although complete surgical resection is the standard treatment for MEC, we should aggressively consider adjunctive ...
A 16 year old man underwent an allogeneic bone marrow transplantation (BMT) from an HLA identical sibling donor for acute lymphoblastic leukaemia in 1984. He developed chronic graft versus host disease involving the skin and kidneys. At day 400 after BMT his condition was complicated by obstructive airways disease, which was partially responsive to azathioprine and steroids. Five years after withdrawal of immunosuppressive treatment he developed dyspnoea and decreased pulmonary function test results, and steroid treatment was resumed. Fibrobronchoscopy revealed the presence of a mucoepidermoid carcinoma in the left main bronchus. After surgical laser resection, there was gradual clinical and functional improvement. There was no evidence of recurrence one year after surgery.. ...
Symptoms of Mucoepidermoid including 8 medical symptoms and signs of Mucoepidermoid, alternative diagnoses, misdiagnosis, and correct diagnosis for Mucoepidermoid signs or Mucoepidermoid symptoms.
NOTE: Phase II is complete. Phase II: 1. Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors; 2. Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin. Phase III: 1. Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone. Phase II/III Secondary Objectives: 1. Compare the acute toxicities of these 2 adjuvant treatments; 2. Compare late treatment-related adverse events in patients receiving postoperativeradiation to those receiving concurrent chemoradiation; 3. Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), and the patient cohort ...
E-cadherin is a calcium dependent cell adhesion molecule, important in cell to cell interactions in epithelial tissues. The present study examined E-cadherin expression in normal salivary glands, pleomorphic adenoma, Warthins tumor, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma and adenocarcinoma of salivary glands in paraffin sections using a monoclonal antibody (5H9). This study is firstly reported E-cadherin expression in the salivary gland and tumors.,BR,In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In excretory ducts, high columnar cells showed the strongest reaction at the basal aspect and ductal basal cells were weakly positive or negative, the basement membrane zone lacked staining. No E-cadherin reaction was observed in modified myoepithelial cells and plasmacytoid cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or ...
Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term clinical outcomes and no targeted therapies are available. The majority of MEC tumors contain a t(11;19) chromosomal translocation that fuses two genes, CRTC1 and MAML2, to generate the chimeric protein CRTC1-MAML2. CRTC1-MAML2 displays transforming activity in vitro and is required for human MEC cell growth and survival, partially due to its ability to constitutively activate CREB-mediated transcription. Consequently, CRTC1-MAML2 is implicated as a major etiologic molecular event and a therapeutic target for MEC. However, the molecular mechanisms underlying CRTC1-MAML2 oncogenic action in MEC have not yet been systematically analyzed. Elucidation of the CRTC1-MAML2-regulated transcriptional program and its underlying mechanisms will provide important insights into MEC pathogenesis that are essential
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240 ...
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RAEM. Publicaci n de la Sociedad Argentina de Endocrinolog a y Metabolismo (SAEM) y de la Federaci n Argentina de Sociedades de Endocrinolog a (FASEN).
Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be "just an ulcer". I cannot touch it. It is way far back on my soft pallete. I have to use "miracle mouthwash" before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I havent seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I cant eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. Im going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...
Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be "just an ulcer". I cannot touch it. It is way far back on my soft pallete. I have to use "miracle mouthwash" before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I havent seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I cant eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. Im going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...
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4321 The 11q23 region is a common participant in LOH (Loss of Heterozygosity), observed in 40% of breast cancers, as well as leukemogenic translocations; in this study a search was made for motifs intrinsic to the region that promote recombinogenic events. The human mucoepidermoid carcinoma cell line, H292, was used for initial study on radiation-induced LOH. Here, 5 x 105 cells were exposed to either 4 or 8 Gy, surviving single cells expanded into colonies of 100 cells or more, the colonies isolated and regrown from single cells. 150 separate clones were analyzed in total. After expansion of the doubly picked clones, LOH analysis of chromosome 11 was performed using polymorphic markers at 6 locations both distal and proximal to 11q23 using a genetic analyzer. A total of 38 LOH events were observed within the irradiated groups. A hot spot for LOH was observed at 11q23.2 (Marker 744724) positive in 8/49 and 6/50 clones after 4 and 8 Gy exposure respectively. No LOH was observed centromeric to ...
This most common malignant salivary gland tumour involves minor glands, and accounts for 9.5-23% of all minor gland tumours {669,704,2711}. About half of the cases arise in the palate and other common sites include the buccal mucosa, lips, floor of oral cavity and retromolar pad. They appear to be much more frequent in the lower lip than the upper lip {1871}. The tumour is often asymptomatic and detected during a routine dental examination.Many appear as bluish, domed swellings that resemble mucoceles or haemangiomas. Less commonly, the surface appears granular or papillary. Tumours of the base of tongue or oropharynx may cause dysphagia and sublingual tumours can lead to ankyloglossia and dysphonia. High-grade tumours are uncommon but can result in ulceration, loosening of teeth, paraesthesia or anaesthesia. Mucoepidermoid carcinoma is the most common salivary gland tumour to develop in a central location within the bone of the mandible or, less frequently, the maxilla {280}. The microscopical ...
Paraneoplastic syndromes.. Pathology and tumours of the naso-pharyngeal region: general features; specifically: naso-pharyngeal carcinoma.. Larynx: general features; specifically: nodules and polyps of the vocal cords; solitary papilloma and papillomatosis; Laryngeal carcinoma and precursor lesions.. Diseases of the Thymus. Developmental disorders.. Thymic hyperplasia.. Thymomas.. (A, AB, B1, B2, B3, C).. Thymic carcinoid.. Salivary gland pathology. Pleomorphic adenoma, Warthin tumor; acinic cell carcinoma; mucoepidermoid carcinoma; adenoid-cystic carcinoma; benign and malignant lympho-epithelial lesions. Cysts of the head and neck region.. Diseases of the Gastro-Intestinal system. Esophageal diseases. Pathology and pathogenesis of: esophagitis, Barretts esophagus, squamous carcinoma and adenocarcinoma of the esophagus. Non neoplastic gastric diseases. Pathology and pathogenesis of: gastritis (acute and chronic) and gastric ulcer (peptic and acute). Ménétrieres disease.. Tumor and tumorlike ...
Head and Neck Cancer is a term used to describe a number of different malignant tumours that develop in or around the throat, larynx, nose, sinuses, and mouth.. Most Head and Neck Cancers are Squamous Cell Carcinomas. This type of cancer begins in the flat, squamous cells that make up the thin layer of tissue on the surface of the structures in the head and neck. Directly beneath this lining, which is called the epithelium, some areas of the head and neck have a layer of moist tissue, called the mucosa. If a cancer is limited to the squamous layer of cells, it is called Carcinoma in Situ. If the cancer has grown beyond this cell layer and moved into the deeper tissue, then it is called Invasive Squamous Cell Carcinoma.. If a Head and Neck Cancer starts in the salivary glands, the tumour will usually be classified as an adenocarcinoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma. ...
Mucoepidermoid carcinoma of the lung is a rare subtype of bronchial adenoma first described 35 years ago by Smetana et al. Although initially perceived to be a slow-growing neoplasm exhibiting local but not distant spread, dissemination was later described by Ozlu et al in 1961. Widespread metastases have since been described by many authors. Of […] ...
History: Cryptotanshinone (CT) is a biologically active compound from the root of that has been reported to induce apoptosis in various malignancy cell lines; but it has not yet been fully explored in human mucoepidermoid carcinoma (MEC). of MC-3 cells results in anti-proliferative and apoptotic activities in MC-3 and it is accompanied by a decrease in phosphorylation and dimerization of transmission transducer and activators of transcription 3 (STAT3). CT decreased the expression levels of myeloid cell leukemia-1 (Mcl-1) and surviving whereas Bcl-xL expression was not changed. CT obviously regulates survivin proteins in a transcriptional alters and level Mcl-1 through proteasome-dependent proteins degradation. Furthermore CT-induced apoptotic cell loss of life in YD-15 another individual MEC cell series was from the inhibition BMS-650032 of STAT3 phosphorylation. Bottom line: These data claim that CT BMS-650032 is actually a great apoptotic inducer through adjustment of STAT3 signaling in ...
We submit the case of a child afflicted with a mucoepidermoid bronchial tumor. The patient is a boy, aged seven, who after undergoing antibiotic treatment for six weeks because of a fever and atelectasia-condensation in the right lower lobe showed no signs of clinical improvement and was sent to our department to undergo further study and treatment. A bronchoscopy performed shows a polypoid mass that partially blocks the main bronchial tube a few milimiters under the access to the right upper lobe. A biopsy is carried out and the anatomopathological test shows there is a low degree epidermoid carcinoma ...
MAML3兔多克隆抗体(ab90593)可与小鼠, 人样本反应并经IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage 0 Hypopharyngeal Cancer Stage 0 Laryngeal Cancer Stage 0 Lip and Oral Cavity Cancer Stage I Adenoid Cystic Carcinoma of the Oral Cavity Stage I Mucoepidermoid Carcinoma of the Oral Cavity Stage I Squamous Cell Carcinoma of the Hypopharynx Stage I Squamous Cell Carcinoma of the Larynx Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity Stage I Verrucous Carcinoma of the Larynx Stage I Verrucous Carcinoma of the Oral Cavity Stage II Adenoid Cystic Carcinoma of the Oral Cavity Stage II Mucoepidermoid Carcinoma of the Oral Cavity Stage II Squamous Cell Carcinoma of the Hypopharynx Stage II Squamous Cell Carcinoma of the Larynx ...
Immunostaining for p63, p504S and the androgen receptor status are important markers for carcinomas of the prostate. The purpose of this study was to investigate the staining characteristics of these markers for malignancies of salivary gland origin. Wax blocks of 32 malignant salivary gland neoplasms were retrieved, sections prepared and stained by the H&E method and immunoperoxidase techniques for the demonstration of p63 (Dako N1604), p504S (Dako N1609) and androgen receptors (Dako M3562). The sections were viewed by light microscopy and positivity scored with the aid of a grading scale. Androgen receptor- and p504S positivity were infrequently observed in the study samples, except for salivary duct carcinoma and mucoepidermoid carcinoma where most of the cases stained positive for p504S. The staining pattern of adenoid cystic carcinomas for p63 correlated with the microscopic subtype. The basal- and intermediate cells of mucoepidermoid carcinomas stained positive- and the mucus- and epidermoid
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Salivary gland tumors are more likely to be cancerous in children when compared to adults. About half of the salivary gland tumors are cancerous in children. Most of the tumors occur in a salivary gland called parotid gland (located at the angle of the jaw below the ear lobes on both sides). The types of cancerous salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma and adenocarcinoma NOS.. ...
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
Discussion: Parotid gland neoplasms are quite rare in the pediatric population but when such a lesion is encountered, a higher percentage (40-50%) will be malignant when compared to the adult population (25-35%); therefore, parotid neoplasms in children must be approached with suspicion (1). The mean age at which malignant parotid gland neoplasms occur in the pediatric population is 13.2 years (2). Acinic cell carcinoma (ACC) accounts for an appreciable number of pediatric parotid malignancies; in fact, it is the second most common malignant parotid tumor in this population followed by mucoepidermoid carcinoma (3). Nasse first described the lesion in a 1892 publication in which four cases of parotid adenomas were described (4). Due to the similarity of the tumor cells to normal salivary tissue, the lesions were initially regarded as benign. The benignity of the lesion was questioned in 1953 when Buxton et al. reported three cases of ACC with verified distant metastases (5). Therefore, the lesion ...
Answer: Necrotizing sialometaplasia. Histology: The stroma surrounding the proliferation of bland squamous epithelium in this case is highly inflamed, and shows focal necrosis. The nests of squamous epithelium may appear to be invasive, but on low power have an overall lobular, branching architecture to them. Focally one may see a benign residual duct of native minor salivary gland. Significant cytologic atypia and mitotic activity are not evident. The findings are consistent with necrotizing sialometaplasia, representing squamous metaplasia of injured salivary gland ductal epithelium, typically in the setting of an ischemic insult. Discussion: Invasive squamous cell carcinoma would be highly unusual in this age group, and would demonstrate greater cytological atypia and an infiltrative growth pattern. Mucoepidermoid carcinoma could be suggested by the presence of proliferating squamous epithelium in associationwith the benign residual ducts of the minor salivary gland. The lobular nature of the ...
Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is rare, with several names used in the past. Synonyms have included cylindroma, ceruminoma, ceruminous adenocarcinoma, not otherwise specified (NOS), ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/2 of the external auditory canal as a primary site. If this area is not involved, the diagnosis should be questioned. The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common symptom, followed by either sensorineural or conductive hearing loss, tinnitus or drainage (discharge). A mass lesion may be present, but it is often slow growing. Imaging studies are used to define the extent of the tumor and to exclude direct extension from the parotid gland or nasopharynx. The imaging findings are usually non-specific, and cannot give a ...
|b||i|Background: |/i||/b|Salivary gland tumors (SGTs) are known for their specific heterogeneity and ambiguous outcome for the affected patients. The |i|LKB1 |/i|a
We show that TRH mRNA is expressed in human fetal and adult pancreata, and that TRHR mRNA is expressed in fetal human pancreas but not in adult human pancreas. Comparative evaluation between two immunoenzymatic techniques (FAST and cialis reviews by men Phadezym) and the Phadebas RAST in food allergy. Implications for community interventions and directions for future research are discussed.. PBX1 expression correlated with histologic neuroblastoma cialis pills subtypes, with highest expression in benign ganglioneuromas and lowest in high-risk neuroblastomas. Insulin temperature and stability under simulated transit conditions.. We attempted a meta-analysis of telemedicine research studies of the costs associated with telemedicine. The purpose of this study is to evaluate the usefulness of dual-time-point 18F-FDG cialis patent expiration date extended PET/CT for discriminating between benign and malignant salivary gland tumors. The study included 18 eyes of 16 patients who underwent cataract ...
TY - JOUR. T1 - Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation. AU - Varsegi, Mary F.. AU - Ravis, Scott M.. AU - Hattab, Eyas M.. AU - Henley, John D.. AU - Billings, Steven D.. PY - 2008/6. Y1 - 2008/6. N2 - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a case of widespread cutaneous metastasis from acinic cell carcinoma arising in a 59-year-old woman with a history of acinic cell carcinoma of the parotid gland 20 years prior to her cutaneous disease. To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma.. AB - Acinic cell carcinoma is a rare, low-grade malignant salivary gland neoplasm. Approximately, 20% of patients experience local recurrence and 10% distant metastasis, often many years after initial presentation. We present a ...
Objective:The Purpose of this study was to analyze the clinical presentation, histopathology and complications following parotid surgery. Methods: We retrospectively reviewed the charts of 112 Patients who underwent parotidectomy from January 2000 to February 2010. Data including age, sex, clinical signs and symptoms, histology and complication were collected from medical records. Results: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors. The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%). Analysis of the correlation between fine-needle aspiration cytology and final histology revealed that fine-needle aspiration sensitivity, specificity and accuracy to 86.6%, 97.6% and 94.6% respectively. The most common complication following parotidectomy was transient facial nerve palsy (18.7%). Conclusions: Superficial parotidectomy is associated with a decrease incidence of transient facial nerve dysfunction
Objective: The purpose of this study was to analyze the clinical presentation, histopathology and complications following parotid surgery. Methods: We retrospectively reviewed the charts of 112 patients who underwent parotidectomy from January 2000 to February 2010. Data including age, sex, clinical signs and symptoms, histology and complication were collected from medical records. Results: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors. The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%). Analysis of the correlation between fine-needle aspiration cytology and final histology revealed that fine-needle aspiration sensitivity, specificity and accuracy to 86.6%, 97.56% and 94.64% respectively. The most common complication following parotidectomy was transient facial nerve palsy (18.7%). Conclusion: Superficial parotidectomy is associated with a decrease incidence of transient facial nerve dysfunction
Background: Dentigerous cyst is the most common type of developmental odontogenic cyst which originates from REE. It has the capacity for transformation to ameloblastoma, mucoepidermoid carcinoma and squamous cell carcinoma. ki-67 and PCNA are two cell proliferation markers which can be both detected in cysts and tumors of epithelial origin. ...
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Build: Sat Nov 17 23:53:08 EST 2018 (commit: a759bb7). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
We have shown that alectinib is a potent ALK inhibitor and is being evaluated in clinical trials for the treatment of ALK fusion-positive non-small cell lung cancer (NSCLC). Recently, RET and ROS1 fusion genes have been implicated as driver oncogenes in 1-2% of NSCLC and have been developed into promising molecular targets for antitumor agents. Here, we investigate the additional target indication of alectinib by testing its ability to inhibit the activity of RET and ROS1 kinases. In enzyme assay, alectinib showed kinase inhibitory activity against RET as wells as ALK but did not show against ROS1. Alectinib inhibited the growth of LC-2/ad cells harboring CCDC6-RET and Ba/F3 cells expressing KIF5B-RET by suppressing RET phosphorylation. Alectinib also showed antitumor activity in mouse models of RET fusion-positive tumors (LC-2/ad cells and Ba/F3 cells expressing KIF5B-RET) and of ALK fusion-positive tumors (NCI-H2228 cells harboring EML4-ALK). In addition, alectinib showed kinase inhibitory ...
Acinic cell carcinoma (ACC) is a low-grade salivary gland malignancy characterized by serous acinar differentiation. Most ACCs arise in the parotid gland, but ACCs have been reported to originate in nonparotid salivary glands where serous acini are less abundant. Given the recent discovery of mammary analog secretory carcinoma (MASC)-a salivary malignancy that histologically mimics ACC-a retrospective reevaluation of nonparotid ACCs is warranted. The surgical pathology archives of The Johns Hopkins Hospital were searched for all ACCs arising outside of the parotid gland. For each case, the histologic slides were reviewed; immunohistochemical analysis (mammaglobin, S100 protein) was performed; and confirmatory ETV6 breakapart fluorescence in situ hybridization assay was completed. Demographic and clinical data were obtained from the medical records. Fourteen extraparotid tumors diagnosed as ACC were identified. Eleven of 14 (79%) tumors harbored the ETV6 translocation (oral cavity=9 of 11; ...
Dr. Lakshmi Kavitha Reader. Publications. 1)Cleidocranial dysplasia. Indian Journal of Dental Advancements 2009;1(1):52-55.. 2)Radiological evaluation of a large complex odontoma by computed tomography. Journal of Clinical Dentistry. 2011; 5(6):1307-1309. 3)CT imaging findings of a calcifying epithelial odontogenic tumor. British Journal of Radiology. 2012; 85:e14-e16.. 4)Imaging characteristics of diffuse large cell extra nodal Non - Hodgkins lymphoma involving palate and maxillary sinus: A case report. Imaging Science in Dentistry 2012; June. 5) Unusual imaging appearance of unicysticameloblatoma: a case report. Contemporary Clinical Dentistry 2012; 3(4):44-47. 6) Denture stomatitis : A review.IJDA 2013; 5(1):1107-1112. 7) Erupted compound odontoma: report of a rare case. J Oral and Maxillofacial Radiology2013;1:83-85.. 8) Mucoepidermoid carcinoma misdiagnosed as a palatal abscess: A diagnostic enigma; Journal of Oral Sign 2013, Vol 5, No 2 9) Hereditary Hypohidrotic EctodermalDysplasia: ...
NOTOC__ {{Acinic cell carcinoma}} {{CMG}}; {{AE}} {{RG}} == Overview == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. == Primary Prevention == There are no established measures for the [[primary prevention]] of [[acinic cell carcinoma]]. ==References== {{Reflist,2}} {{WH}} {{WS ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of "hybrid carcinomas" that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Introduction Minor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study...
So-called acinic cell carcinoma of the breast arises from microgladular adenosis and is not a distinct entity.. Mod Pathol. 2017 Oct;30(10):1504. Authors: Rosen PP. PMID: 28972583 [PubMed - in process]. ...
Types of cancer found in the nasal and sinus cavities: Adenocarcinomas and mucoepidermoid cancers (cancers arising from gland cells) are the next most frequent type. Malignant lymphomas, a cancer arising from lymph or immune system cells. Malignant melanoma a cancer of pigment or skin color containing cells. Esthesioneuroblastomas come from the olfactory nerves, the nerves which govern the sense of smell. These cancers usually occur on the roof of the nasal cavity and involve a structure called the cribriform plate, which is a bone deep in the skull.
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two Phase 1 studies in patients with advanced or metastatic solid tumors, including patients with active CNS disease. Here we summarize the overall safety and report the antitumor activity of entrectinib in a cohort of patients with tumors harboring NTRK1/2/3, ROS1, or ALK gene fusions, naïve to prior TKI treatment targeting the specific gene, and who were treated at doses that achieved therapeutic exposures consistent with the RP2D. Entrectinib was well tolerated, with predominantly Grades 1/2 adverse events that were reversible with dose modification. Responses were observed in NSCLC, colorectal cancer, mammary analog secretory carcinoma, melanoma, and renal cell carcinoma, as early as 4 weeks after starting treatment and lasting as long as , 2 years. Notably, a complete CNS response was achieved in a patient with SQSTM1-NTRK1-rearranged lung cancer. ...
As the last boomers hit 50 in 2014, here is advice for people in their 50s about handling caregiving duties and costs for your elderly parents.
Parotid Gland Acinic Cell Carcinoma (Acinic Cell Carcinoma of Parotid): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
This lesion is described as a soft tissue enlargement. Reactive soft tissue enlargements can be excluded from differential diagnosis because the lesion has been present for several years and is progressively enlarging. Also, the lesion is not painful, except for occasional soreness associated with the denture.. Within the category of tumors, malignant tumors can be excluded because the lesion is very slowly growing and essentially asymptomatic. Soft tissue cysts are eliminated because they are fluid filled and have “hydraulic†properties, meaning that they are compressible and expand in all directions uniformly. Cysts do not have a surface with a depression or fissure.. From the category of benign tumors, epithelial lesions and salivary gland tumors can be excluded. Epithelial lesions can be excluded because these have a white, rough surface. Salivary gland tumors can be excluded because the lesion appears to be arising from the alveolar ridge mucosa. Salivary gland tumors may arise ...
1BHY: Multiwavelength anomalous solvent contrast (MASC): derivation of envelope structure-factor amplitudes and comparison with model values.
[IMG] TheReeflexCube magnetic ballasts for HQI lamps are a mix of tried-and-true technology and innovative design. The advanced cooling...
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Conditions: Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent ...
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Examples adenoid cystic carcinoma cribriform adenocarcinoma of minor salivary glands polymorphous adenocarcinoma pleomorphic adenoma (...)
Most salivary gland tumors are benign and occur in parotid gland. The most common sign of a salivary gland tumor is a painless mass.
To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference ( ...
TY - JOUR. T1 - AKT3 drives adenoid cystic carcinoma development in salivary glands. AU - Zboray, Katalin. AU - Mohrherr, Julian. AU - Stiedl, Patricia. AU - Pranz, Klemens. AU - Wandruszka, Laura. AU - Grabner, Beatrice. AU - Eferl, Robert. AU - Moriggl, Richard. AU - Stoiber, Dagmar. AU - Sakamoto, Kazuhito. AU - Wagner, Kay Uwe. AU - Popper, Helmut. AU - Casanova, Emilio. AU - Moll, Herwig P.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic ...
A primary or metastatic malignant neoplasm affecting the head and neck. Representative examples include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Adenoid cystic carcinomas are a rare histological subtype of adenocarcinoma. Pathology Adenoid cystic carcinomas are generally considered low grade 4. The tumours have a notable tendency for perineural spread. Location They have a wide distri...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Salivary gland tumors most commonly occur in the parotid gland, accounting nearly 85% of all salivary gland tumors. But, 25% of parotid tumors are malignant (cancerous).. Pleomorphic adenoma is the most common type of benign salivary gland tumor. It is typically a slow growing tumor and occur most often in the parotid gland. It is also known as mixed tumor which describes its pleomorphic appearance as opposed to its dual origin from epithelial and myoepithelial elements.. The tumor is usually solitary and presents as a slow growing, painless and firm singular nodal mass. It is usually mobile unless found in the palate and can cause atrophy of the mandibular ramus when located in the parotid gland.. ...
... - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
BRAF V600 mutations occur in a wide range of tumor types and RAF inhibition has become standard in several of these cancers. Despite this progress, BRAF V600 mutations have historically been considered a clear demonstration of tumor lineage context-dependent oncogene addiction, based predominantly on the insensitivity of RAF inhibition in colorectal cancer. However, the true broader activity of RAF inhibition pan-cancer remains incompletely understood. To address this, we conducted a multi-cohort basket study of the BRAF inhibitor vemurafenib in non-melanoma BRAF V600 mutation-positive solid tumors. In total, 172 patients with 26 unique cancer types were treated, achieving an overall response rate of 33% and median duration of response of 13 months. Responses were observed in 13 unique cancer types, including historically treatment-refractory tumors such as cholangiocarcinoma, sarcoma, glioma, neuroendocrine carcinoma, and salivary gland carcinomas. Collectively, these data demonstrate that ...
Li, N., Xu, L., Zhao, H., El-Naggar, A. K. and Sturgis, E. M. (2012), A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer, 118: 3945-3953. doi: 10.1002/cncr.26740 ...
Pleomorphic adenoma, also known as benign mixed tumor, is the most common tumor of salivary gland origin, accounting for about 60-70% of all salivary gland tumors (Peel and Seethala, 2007; Downer, et al., 2011; Papadogeorgakis ...
Timothy J. Kelly, MD, FACS, is an otolaryngologist provider specializing in adult & pediatric ENT care, thyroid & salivary gland neoplasms and pediatric airway.
January 11, 2013 FC Barcelona easily qualified for the Copa del Rey quarter finals last night after a 5-0 win against Cordoba, for an aggregate of 7-0. Goals came from Thiago just after the quarter hour mark, and two each from Villa and Alexis. With Tito Vilanova in New York seeking a second opinion on the treatment for his salivary gland tumour, Jordi Roura was once agan in charge. While the result was good, Barça suffered two injuries; Sergi Roberto was replaced just after the second half started, while David Villa came off 12 minutes before the end with a thigh strain.. Barça will face Malaga in the quarter finals. The first leg will be played at home on January 16th, with the away leg on the 23rd.. 1-0 Thiago (min 16 ...
Adenoid cystic carcinoma: Tends to infiltrate perineural spaces and causes pain. (This well have to remember, unless you submit us a mnemonic! =D ) ...
Mouse monoclonal antibody raised against full length recombinant human MAML2. Recombinant protein corresponding to full length human MAML2. (MAB15048) - Products - Abnova
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Discussion: Myoepithelial carcinomas (or malignant myoepitheliomas) are rare malignant salivary gland neoplasms in which the tumor cells show myoepithelial differentiation. The entity was first described by Stromeyer et al. in 1975. The tumor was included in the WHO classification of salivary gland neoplasms as a distinct clinicopathologic entity in 1991. About 60% to 70% of myoepithelial carcinomas develop in a benign mixed tumor (carcinoma ex pleomorphic adenoma), and the remainder arise de novo. Histologically, malignant myoepitheliomas are composed of one or several cell types: spindle, plasmacytoid, epithelioid, and clear cells. Frequently, one of the cell types predominates. The neoplastic cells grow either as multiple nodules or as large solid sheets separated by variable amounts of intervening hyaline or myxoid stroma. By far, the multinodular growth pattern is more prevalent. The cytologic features generally reflect the histology. The cytologic smear can show spindle, epithelioid or ...
TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
Rhabdomyosarcoma comprises two major subtypes, fusion positive (PAX3-FOXO1 or PAX7-FOXO1) and fusion negative. To investigate the significance of DNA methylation in these subtypes, we analyzed methylation profiles of 37 rhabdomyosarcoma tumors and 10 rhabdomyosarcoma cell lines, as well as 8 normal tissues. Unsupervised clustering of DNA methylation clearly distinguished the fusion-positive and fusion-negative subsets. The fusion-positive tumors showed substantially lower overall levels of methylation compared with fusion-negative tumors. Comparison with the methylation pattern of normal skeletal muscle and bone marrow indicates that fusion-negative rhabdomyosarcoma is more similar to these normal tissues compared with fusion-positive rhabdomyosarcoma, and suggests that many of the methylation differences between these subtypes arise from aberrant hyper- and hypomethylation events in fusion-positive rhabdomyosarcoma. Integrative methylation and gene expression analysis revealed that ...
Adenoid cystic carcinoma is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In a brief report published on 17 June 2013 in theJournal of Clinical Investigation, researchers led by Andrew Futreal of the Cancer Genome Project, Wellcome Trust Sanger Institute in Cambridge, United Kingdom, reported on a whole exome sequencing performed in 24 adenoid cystic carcinoma cases.. They uncovered the involvement of multiple cancer genes that are likely to be contributing to tumour development in the context of MYB activation. The data point to disruption of chromatin regulation as a major factor in adenoid cystic carcinoma development. Furthermore, the data implicate NOTCH signalling deregulation in a proportion of cases. Finally, the analysis has identified activating mutations of the receptor tyrosine kinase FGFR2 in ...
Kimberly Smith admired her brother-in-law for his kindness and thoughtfulness, as well as his courageous fight with stage IV adenoid cystic carcinoma (ACC), a rare cancer, when he was only 26 and newly married. In his honor, the family established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research at MD Anderson.
TY - JOUR. T1 - The mutational landscape of adenoid cystic carcinoma. AU - Ho, A.S.. AU - Kannan, K.. AU - Roy, D.M.. AU - Morris, L.G.T.. AU - Ganly, I.. AU - Katabi, N.. AU - Ramaswami, D.. AU - Walsh, L.A.. AU - Eng, S.. AU - Huse, J.T.. AU - Zhang, J.N.. AU - Dolgalev, I.. AU - Huberman, K.. AU - Heguy, A.. AU - Viale, A.. AU - Drobnjak, M.. AU - Leversha, M.A.. AU - Rice, C.E.. AU - Singh, B.. AU - Iyer, N.G.. AU - Leemans, C.R.. AU - Bloemena, E.. AU - Ferris, R.L.. AU - Seethala, R.R.. AU - Gross, B.E.. AU - Liang, Y.P.. AU - Sinha, R.. AU - Peng, L.K.. AU - Raphael, B.J.. AU - Turcan, S.. AU - Gong, Y.X.. AU - Schultz, N.. AU - Kim, S.. AU - Chiosea, S.. AU - Shah, JP. AU - Sander, C. AU - Lee, W.. AU - Chan, T.A.. PY - 2013. Y1 - 2013. U2 - 10.1038/ng.2643. DO - 10.1038/ng.2643. M3 - Article. VL - 45. SP - 791. EP - 798. JO - Nature Genetics. JF - Nature Genetics. SN - 1061-4036. IS - 7. ER - ...
Chris (and any one else who might have some information), I guess I should have been more clear in my request for mouse mammary tumor Abs. Yes, I assume that human cytokeratin Abs will cross-react with the mouse tissue. They have done so on all other species that Ive used them on here in the Vet Diag Lab. What I need is an antibody specific for mammary tumor, so that we can differentiate these tumors from salivary gland tumors, etc. I need to be able to say that it is more than just an epithelial tumor, or even more than a glandular or ductual epithelial tumor. Is there such a beast that will work in mouse tissue? And thanks for the recommendation of using the ARK kit from DAKO. I do have one on hand. Jan ----- Original Message ----- From: C.M. vander Loos ,[email protected], To: ,[email protected], Cc: Jan Shivers ,[email protected], Sent: Thursday, December 14, 2000 2:58 AM Subject: Re: mouse mammary tumor Ab , ,Does anyone know where I could find an antibody ...
Neck surgery, Head surgery, Facial reanimation surgery, Transoral robotic surgery, Reconstructive surgery, Laryngeal ca...ncer, Head and neck cancer, Soft palate cancer, Thyroid cancer, Nasal and paranasal tumors, Throat cancer, Skin tumor, Oral and throat cancer, Mouth cancer, Salivary gland tumor. ...
Dr.Meenesh Juvekar. M.S (ENT), D.N.B, D.O.R.L, M.N.A.M.S (Ear-Nose-Throat & Head Neck surgeon) Call 91+022-25271150 for appointment
Build: Mon Nov 12 13:52:52 EST 2018 (commit: 8a5bcf7). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Extracapsular dissection can be an effective and low-risk method for removing benign, supercial parotid tumors that are less than 4 cm. ...
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Bardella always in pioneering fashion and geared towards the market, Bardella was able to adapt to and often anticipate the requirements a constantly evolving ...
Background: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG). Methods: Cases including 66 PA (35 FNA, 31 resections), 12 BCA (5 FNA, 7 resections), 42 ACC (11 FNA, 31 resections), 1 BCAC FNA, and 10 NNSG (5 FNA, 5 resections) were obtained and stained for LEF-1. Results: On cell block (CB), 51% of PA and 60% of BCA were LEF-1 positive while 91% of ACC were LEF-1 negative. Among resections, there was a higher percentage of LEF-1 positive PA (84%) and BCA (86%), and a higher percentage of LEF-1 negative ACC (97%). LEF-1 ...
Definition of auricular nerve, great in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is auricular nerve, great? Meaning of auricular nerve, great as a legal term. What does auricular nerve, great mean in law?
Define auricular nerve, posterior. auricular nerve, posterior synonyms, auricular nerve, posterior pronunciation, auricular nerve, posterior translation, English dictionary definition of auricular nerve, posterior. n. 1. Any of the cordlike bundles of fibers made up of neurons through which sensory stimuli and motor impulses pass between the brain or other parts of the...
Mucoepidermoid carcinoma • Mucogingival junction • Mucosal lichen planus • Mucous membrane pemphigoid • Mucous retention cyst ... Acinic cell carcinoma • Acrodont • Adalbert J. Volck • Adenomatoid odontogenic tumor • Adhesive Dentistry • Aetna • Agar • ...
53:105-8. Tandon DA, Deka RC & Chowdhury C. (1985). Mucoepidermoid carcinoma of the larynx. Ear Nose Throat J. 64:555-7. Bhatia ... 1980). Middle-ear carcinoma in a girl of eighteen. J Laryngol Otol. 94:429-31. Witter HL, Deka RC, Lipscomb DM & Shambaugh GE ...
Pleural carcinomas *Pleural mucoepidermoid carcinoma. *Pleural pseudomesotheliomatous adenocarcinoma. See also[edit]. *Pleural ...
Tumours of the salivary glands may occur, including mucoepidermoid carcinoma. The salivary glands of some species however, are ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature ... "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign ... "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research. 12 (13): 3902- ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nat. Genet. ... "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign ... "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clin. Cancer Res. 12 (13): 3902-7. doi: ... "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: ...
The most common form of malignant parotid neoplasms are mucoepidermoid carcinomas. The exact cause of malignant parotid tumors ...
The malignant tumors include ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. List of ...
Eventually, it may cause mucoepidermoid carcinoma and possibly other malignancies such as prostate cancer. HCMV is found ... "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic ...
Shieh YS, Chang LC, Chiu KC, Wu CW, Lee HS (2003). "Cadherin and catenin expression in mucoepidermoid carcinoma: correlation ...
Occasionally the wall of a dentigerous cyst may give rise to a more ominous mucoepidermoid carcinoma. Due to the tendency for ...
... ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/ ... NOS Ceruminous adenoid cystic carcinoma Ceruminous mucoepidermoid carcinoma All of the tumors are infiltrative into the soft ... The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types. ... especially when dealing with an adenoid cystic or mucoepidermoid carcinoma. This can be eliminated by clinical or imaging ...
... with the most common tumors being mucoepidermoid carcinoma and adenoid cystic carcinoma. Other malignant tumors of the parotid ... squamous cell carcinoma (arising from parenchyma of parotid gland), and undifferentiated carcinoma. Metastasis from other sites ... gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma (arising from ductal epithelium of parotid ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature ...
It may be confused with a number of benign and malignant neoplasms, including Warthin tumour, mucoepidermoid carcinoma and ...
... and mucoepidermoid carcinomas. Rarer still are melanomas and lymphomas of the upper aerodigestive tract. Around 75% of cases ... Squamous cell carcinoma is most likely to appear in males over 40 years of age with a history of heavy alcohol use coupled with ... Squamous-cell carcinoma is a cancer of the squamous cell - a kind of epithelial cell found in both the skin and mucous ... Oropharyngeal squamous cell carcinomas (OSCC) begins in the oropharynx (throat), the middle part of the throat that includes ...
... mucoepidermoid carcinoma, and pulmonary mucinous bronchioloalveolar carcinoma. The mouse monoclonal antibody 1D3, developed to ... mucoepidermoid carcinoma, mucinous bronchioloalveolar carcinoma, signet ring cell adenocarcinoma, mucinous cystadenocarcinoma, ... Tsuta K; Ishii G; Nitadori J (May 2006). "Comparison of the immunophenotypes of signet-ring cell carcinoma, solid ... For treatment purposes, MCACL has been traditionally considered a non-small cell lung carcinoma (NSCLC). Complete radical ...
... is associated with mucoepidermoid carcinoma and possibly other malignancies. Not all oncoviruses are DNA viruses. Some RNA ... "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma". ... Although this agent was the clear cause of hepatitis and might contribute to liver cancer hepatocellular carcinoma, this link ...
Example would be to distinguished between high grade Mucoepidermoid Carcinoma of the parotid, which stains positive vs Squamous ... Cell Carcinoma of the parotid which does not. Lazcano, O (Jan 1993). "Combined histochemical stains in the differential ...
... or primary mucoepidermoid cutaneous carcinoma) is a malignant adnexal tumor of the sweat gland. It is the malignant variant of ... Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine carcinoma, ...
Human cytomegalovirus (CMV or HHV-5) is associated with mucoepidermoid carcinoma and possibly other malignancies.[46] ... Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic ...
... including mucoepidermoid carcinoma, a malignant growth.[37]. Clinical tests/investigationsEdit. A sialogram is a radiocontrast ... "Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma". Cancer. ...
... or the malignant squamous cell carcinoma and mucoepidermoid carcinoma. Treatment ranges from simple enucleation of the cyst to ... central mucoepidermoid carcinoma). There are cysts, e.g. buccal bifurcation cyst with self-resolation nature, in which close ... these can appear solitary or associated with the Gorlin-Goltz or Nevoid basal cell carcinoma syndrome. The latest World Health ...
... carcinoma, lobular MeSH C04.557.470.200.025.340 --- carcinoma, mucoepidermoid MeSH C04.557.470.200.025.370 --- carcinoma, ... carcinoma, mucoepidermoid MeSH C04.557.470.590.415 --- carcinoma, signet ring cell MeSH C04.557.470.590.415.410 --- krukenberg ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ... carcinoma, krebs 2 MeSH C04.557.470.200.260 --- carcinoma, large cell MeSH C04.557.470.200.280 --- carcinoma, lewis lung MeSH ...
... papilliferum Cystadenoma Malignant epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma ... not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma Mammary analogue secretory carcinoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... Carcinosarcoma Metastasizing pleomorphic adenoma Squamous cell carcinoma Large cell carcinoma Lymphoepithelial carcinoma ...
... lining and the potential for recurrence with characteristics similar to a central variant of low-grade mucoepidermoid carcinoma ... This lesion may be associated with the Nevoid basal cell carcinoma syndrome. Buccal bifurcation cyst which appears in the ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ...
Renal cell carcinoma (M8312/3) Grawitz tumor (8390-8420) Adnexal and Skin appendage Neoplasms (8430-8439) Mucoepidermoid ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ...
Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can ... Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of ... "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain Histopathologic image of mucoepidermoid carcinoma. Postoperative ... Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal ...
... is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma ( ... is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma ( ...
Fibrobronchoscopy revealed the presence of a mucoepidermoid carcinoma in the left main bronchus. After surgical laser resection ...
N2 - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary ... AB - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary ... Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary ... abstract = "Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. ...
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review ... Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review ... Mucoepidermoid carcinomas (MECs) of lung are rare neoplasms originating in bronchial submucosal glands and comprising 0.1-0.2% ...
It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a ... It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a ...
Head And Heck Mucoepidermoid Carcinoma: Clinicopathologic Study Of 173 Cases. Author: Pires F.R.. Alves F.D.A.. De Almeida O.P. ... Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been ...
... oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases ... oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases ... oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases ... oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases ...
central mucoepidermoid carcinoma ; clinicopathologic profile ; pathogenesis ; immunohistochemistry 刊名: AMERICAN JOURNAL OF ... Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic ... Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese Patients[J]. AMERICAN JOURNAL ... Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese Patients ...
Mucoepidermoid cancer of the trachea. *Squamous cell carcinoma of the trachea. *Tracheal carcinoma ... Mucoepidermoid lung tumors. Ann Thorac Surg 1989; 47:394.. *Molina JR, Aubry MC, Lewis JE, et al. Primary salivary gland-type ... Occurrence of tracheal carcinoma in Finland. Acta Otolaryngol 1991; 111:1162.. *Licht PB, Friis S, Pettersson G. Tracheal ... Adenoid cystic carcinoma of the airway: thirty-two-year experience. J Thorac Cardiovasc Surg 1996; 112:1522. ...
Prognostic factors in mucoepidermoid carcinoma of the salivary glands.. McHugh CH1, Roberts DB, El-Naggar AK, Hanna EY, Garden ... Mucoepidermoid carcinoma (MEC) is the most common malignancy of the major salivary glands. Prior reports noted histological ...
... Salvatore Martellucci,1 Giulio Pagliuca,1 Marco de ... Mucoepidermoid carcinoma of the tongue base gives rise to a rather vague and aspecific symptomatology. Early symptoms include ... A 69-year-old woman with mucoepidermoid carcinoma (MEC) of the tongue base came under our observation complaining of repeated ... We report a case of mucoepidermoid carcinoma of the tongue base mimicking an ectopic thyroid. ...
Mucoepidermoid Carcinomaadmin2018-06-05T15:08:10+00:00 Mucoepidermoid carcinomas represent a distinct type of tumor. They ... Notably, Binder et al cited the misclassification of high-grade mucoepidermoid carcinomas as adenosquamous carcinomas. Likewise ... Reports of mucoepidermoid carcinomas of the subglottis are not common. Women are more commonly affected than men (3:2), and the ... 1) Mucoepidermoid carcinomas were first described by Masson and Berger in 1924. Since then, they have become well recognized as ...
Re: Mucoepidermoid Carcinoma. Hey Marc, Hope all went well with your surgery. I had a mucoepidermoid carcinoma of the parotid ... Re: Mucoepidermoid Carcinoma. Hi Marc. I just found your entry. I also had mucoepidermoid carcinoma. I was diagnosed in 1998 ... Mucoepidermoid carcinoma of the lung. Aurora7. I also was diagnosed with this same cancer, I had a chest x-ray 4 months before ... Re: Mucoepidermoid Carcinoma. I had it in 1969 at age 8. This year I celebrate 37 years of survival. Hope all went well with ...
Mucoepidermoid carcinoma. Reviewer: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Reviewers page). Revised: 24 June 2013, ... End of Penis and scrotum > Other malignancies > Mucoepidermoid carcinoma. This information is intended for physicians and ... Adenosquamous carcinoma: areas of true glandular differentiation, mucin stains glandular but not squamous structures ... Minor component of well-differentiated non-keratinizing squamous cell carcinoma *Resembles similar tumor of cervix Micro images ...
Carcinoma - Mucoepidermoid carcinoma. Reviewer: Nat Pernick, M.D. (see Reviewers page). Revised: 27 September 2013, last major ... Mucoepidermoid carcinoma of the conjunctiva of the lower lid (Indian J Ophthalmol 1996;44:231) *Conjunctival mucoepidermoid ... End of Eye > Conjunctiva > Carcinoma - Mucoepidermoid carcinoma. This information is intended for physicians and related ... Resembles squamous cell carcinoma but with mucus secreting cells, intermediate cells, epidermoid squamous cells and ...
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features. Erratum. ...
CAF induction in mucoepidermoid carcinoma. αSMA immunohistochemistry was carried out in the mucoepidermoid carcinoma specimens ... Mucoepidermoid carcinoma was formerly classified as a benign tumor termed the mucoepidermoid tumor. Most patients have a ... Clinical features of the mucoepidermoid carcinoma cases examined.. Case no.. Gender. Age (years). Primary site. cTNM. ... Mucoepidermoid carcinoma is the most common malignant tumor of the major and minor salivary glands, accounting for ~30% of ...
Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm characterized by proliferation of epidermoid, mucous, and ... Expression of CD34 and D2-40 in different grades of mucoepidermoid carcinoma. ...
... resources and questions answered by our Genetic and Rare Diseases Information Specialists for Mucoepidermoid carcinoma ... of these are mucoepidermoid carcinomas.[1][2] Mucoepidermoid carcinoma develops when a cell. randomly acquires changes (. ... Mucoepidermoid carcinoma is a type of cancer. of the salivary glands. Salivary gland cancer is diagnosed in 2-3 individuals per ... ClinicalTrials.gov lists trials that are related to Mucoepidermoid carcinoma. Click on the link to go to ClinicalTrials.gov to ...
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with ... Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with ... Oncocytic Mucoepidermoid Carcinoma: Clinicopathologic Description in a Series of 12 Cases. Am J Surg Pathol. 2008 Oct 28. PMID ... MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic ...
Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a ... Mucoepidermoid" by people in this website by year, and whether "Carcinoma, Mucoepidermoid" was a major or minor topic of these ... Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. ... "Carcinoma, Mucoepidermoid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
Purpose: Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. Mucoepidermoid carcinoma ... Clinical characteristics of the patients with mucoepidermoid carcinoma. The group of mucoepidermoid carcinoma patients ... Experimental Design: Seventy-one cases of mucoepidermoid carcinoma and 51 cases of nonmucoepidermoid carcinoma salivary gland ... fusion transcript may be specific to mucoepidermoid carcinoma and associated with a distinct mucoepidermoid carcinoma subset ...
Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features ... Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features ...
Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With : Report of a Rare Case in a 17-Year-Old Boy and a Review of ... Mucoepidermoid carcinoma (MEC) with a predominant spindle cell composition occurring in the palatine tonsil is exceedingly rare ...
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