A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Tumors or cancer of the SALIVARY GLANDS.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Accessory salivary glands located in the lip, cheek, tongue, floor of mouth, palate and intramaxillary.
Tumors or cancer of the PAROTID GLAND.
A benign tumor characterized histologically by tall columnar epithelium within a lymphoid tissue stroma. It is usually found in the salivary glands, especially the parotid.
A malignant epithelial tumor of glandular tissue, especially the salivary glands, characterized by acini with mucus-producing cells and by the presence of malignant squamous elements. Most mucoepidermoid tumors are low-grade lesions readily cured by adequate excision. They may appear in any age group. They grow slowly. If high-grade, they behave aggressively, widely infiltrating the salivary gland and producing lymph node and distant metastases. (Dorland, 27th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A benign neoplasm of the ovary.
Cancer or tumors of the MAXILLA or upper jaw.
Tumors or cancer of the BRONCHI.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.
Neoplasms of the sublingual glands.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Tumors or cancer of the MANDIBLE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Diseases of the lacrimal apparatus.
The GENETIC RECOMBINATION of the parts of two or more GENES resulting in a gene with different or additional regulatory regions, or a new chimeric gene product. ONCOGENE FUSION includes an ONCOGENE as at least one of the fusion partners and such gene fusions are often detected in neoplastic cells and are transcribed into ONCOGENE FUSION PROTEINS. ARTIFICIAL GENE FUSION is carried out in vitro by RECOMBINANT DNA technology.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
Extraoral body-section radiography depicting an entire maxilla, or both maxilla and mandible, on a single film.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tumors or cancer of the LUNG.
Tumors or cancer of the LIVER.
Tumors or cancer of the MOUTH.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).
A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.
A plant genus of the family CARYOPHYLLACEAE. Members contain dianthins, which are ribosome inactivating proteins.
Solutions for rinsing the mouth, possessing cleansing, germicidal, or palliative properties. (From Boucher's Clinical Dental Terminology, 4th ed)
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
The first meal of the day.
A cutaneous pouch of skin containing the testicles and spermatic cords.
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
A salivary gland on each side of the mouth below the TONGUE.
The largest of the three pairs of SALIVARY GLANDS. They lie on the sides of the FACE immediately below and in front of the EAR.

Regulation of human airway mucins by acrolein and inflammatory mediators. (1/163)

Bronchitis, asthma, and cystic fibrosis, marked by inflammation and mucus hypersecretion, can be caused or exacerbated by airway pathogens or irritants including acrolein, an aldehyde present in tobacco smoke. To determine whether acrolein and inflammatory mediators alter mucin gene expression, steady-state mRNA levels of two airway mucins, MUC5AC and MUC5B, were measured (by RT-PCR) in human lung carcinoma cells (NCI-H292). MUC5AC mRNA levels increased after >/=0.01 nM acrolein, 10 microM prostaglandin E2 or 15-hydroxyeicosatetraenoic acid, 1.0 nM tumor necrosis factor-alpha (TNF-alpha), or 10 nM phorbol 12-myristate 13-acetate (a protein kinase C activator). In contrast, MUC5B mRNA levels, although easily detected, were unaffected by these agonists, suggesting that irritants and associated inflammatory mediators increase mucin biosynthesis by inducing MUC5AC message levels, whereas MUC5B is constitutively expressed. When transcription was inhibited, TNF-alpha exposure increased MUC5AC message half-life compared with control level, suggesting that transcript stabilization is a major mechanism controlling increased MUC5AC message levels. Together, these findings imply that irritants like acrolein can directly and indirectly (via inflammatory mediators) increase airway mucin transcripts in epithelial cells.  (+info)

Sclerosing Mucoepidermoid carcinoma with eosinophilia of the thyroid glands: a case report with clinical manifestation of recurrent neck mass. (2/163)

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a recently recognized malignant neoplasm of the thyroid gland. About 14 cases of SMECE have been reported and this is the first reported case in Korea. A 57-year-old woman presented with right neck mass for 20 years. Total thyroidectomy was performed under the impression of thyroid carcinoma. The resected thyroid gland showed a poorly circumscribed hard mass. Histologically, the tumor consisted of solid nests of large atypical cells with dense fibrous stroma. The tumor cells showed squamoid appearance with abundant eosinophilic cytoplasm. There were also rare mucin-containing cells within the nests. Within the hyalinized stroma, numerous eosinophils were found. The surrounding thyroid parenchyma displayed Hashimoto's thyroiditis. There was metastasis in a regional lymph node. Two years after initial surgery, she underwent a modified radical neck dissection due to recurrent neck mass. After the radiation therapy for eight weeks, laryngectomy and esophagectomy were performed due to a recurrent carcinoma in the esophageal wall. We report an additional case of SMECE, with metastasis to regional lymph nodes and esophagus. The tumor appears to be more aggressive than previously reported and a correct diagnosis can be rendered by just examining the metastatic lesions.  (+info)

Characterization of CFTR expression in a human pulmonary mucoepidermoid carcinoma cell line, NCI-H292 cells. (3/163)

The NCI-H292 cell, a human pulmonary mucoepidermoid carcinoma cell line, is commonly used for studying bacterial and viral infections of airway epithelial cells. Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) is the main cause of fetal lung infection in cystic fibrosis patients. In this study, we examined CFTR expression in NCI-H292 cells to determine whether NCI-H292 cells possess sufficient, normally functioning CFTR. The results of RT-PCR and Northern blotting analysis indicated that the CFTR gene expression level was much lower in NCI-H292 cells than in T84 cells. However, Western blotting analysis showed that protein expression in NCI-H292 cells was comparable to that in T84 cells. Furthermore, whole-cell and cell-attached patch clamp electrophysiological techniques indicated that the Cl- current induced by intracellular cAMP elevation in NCI-H292 cells was comparable to that in T84 cells. These findings suggest that NCI-H292 cells with a low level of CFTR gene expression possess enough functional CFTR to show a physiological response.  (+info)

Salivary gland tumors in Jordan: a retrospective study of 221 patients. (4/163)

AIM: To evaluate the types and clinical outcome of salivary gland tumors in Jordan. METHODS: Hospital records of 221 patients (85 women and 136 men) with salivary gland tumors, diagnosed from January 1988 to December 1997 were reviewed. The patients were analyzed according to sex, age, histopathological type and site of the tumor. Survival curves for patients with malignant tumors were constructed using Kaplan-Meier's method. RESULTS: Of the total 221 salivary gland tumors, 155 (70.2%) were parotid tumors, 42 (19%) minor salivary gland tumors, 23 (10.4%) submandibular gland tumors, and a single (0.4%) sublingual gland tumor. Most of the tumors (151, or 68.4%) were classified as benign and 70 (31.6%) were malignant. Men to women ratio was 1.6:1, and the age of the patients ranged from 2 to 81 years. The overall 5 and 10 year-survival rates for the 70 malignant tumors were 67% and 53%, respectively, for all tumor stages. Mucoepidermoid carcinoma had the best, and squamous cell carcinoma the worst 10-year survival rate. Patients treated with surgery and subsequent radiation therapy had better survival rates than those treated with surgery or radiation therapy alone. CONCLUSION: The principal site for salivary gland tumors in Jordan population was the parotid, and the pleo- morphic adenoma the most common pathological finding. Tumor characteristics and survival data for the Jordanian population are comparable to those from western countries.  (+info)

Detection of circulating anti-p53 antibodies in esophageal cancer patients. (5/163)

It has been reported that circulating anti-p53 antibodies (p53-Ab) in the serum are detected in some cancers. To investigate the usefulness of detecting p53-Ab, we measured the circulating p53-Ab in comparison with squamous cell carcinoma antigen (SCC-Ag) in patients with esophageal carcinoma. Serum specimens from 46 esophageal cancer patients (42 squamous cell carcinomas, 3 mucoepidermoid carcinomas and 1 basaloid squamous carcinoma) and 13 healthy subjects were studied. Serum p53-Ab was measured by an enzyme-linked immunosorbent assay. Surgically resected specimens from 43 patients were immunohistochemically stained for p53. Serum SCC-Ag was measured by a radioimmunoassay. The results were analyzed with the clinical data and outcome. Serum p53-Ab was detected in 13 (28%) of the 46 patients, but not in any of the healthy subjects. The positive rate was 0% (0/6) in stage I, 60% (3/5) in stage IIA, 30% (3/10) in stage IIB, 29% (7/24) in stage III and 0% (0/1) in stage IV. There was no difference in the outcome between the p53-Ab-positive and p53-Ab-negative patients. Immunohistochemically, 30 (70%) of the 43 specimens stained positively for p53. Serum p53-Ab was detected in 43% (13/30) of the patients with tumors which stained positively for p53. There was a close correlation between positivity for p53 immunostaining and positivity for p53-Ab (p<0.01). An elevated level of SCC-Ag was found in only 13%of the patients, and most patients positive for SCC-Ag already had advanced disease with lymph node metastasis and invasion to the adventitia. In conclusion, serum p53-Ab was detected in Japanese esophageal cancer patients at a frequency similar to that reported in Western countries. Serum p53-Ab may be a potentially useful molecular marker for detection and screening of esophageal cancer. Further studies of a large population may be required to elucidate the true diagnostic usefulness of measuring the serum p53-Ab.  (+info)

Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study. (6/163)

OBJECTIVES: To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. MAIN OUTCOME MEASURES: Demographic data, cancer T- and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. RESULTS: Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. CONCLUSIONS: The N-stage is the main prognostic factor of overall survival, relapse- and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.  (+info)

Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands. (7/163)

CONTEXT: Among the cytological and morphological properties of mucoepidermoid carcinoma, one of the most important criteria for measuring its biological behavior and aggressiveness is cell proliferation. In this way, immunohistochemical markers of cell proliferation have been found to be useful in tumor classification and have formed part of the prognostic and therapeutic studies of these pathologies. OBJECTIVE: To analyze 11 cases of mucoepidermoid carcinoma (MEC) using the proliferation activity marker (PCNA) and to determine its relationship to the grade of malignancy of these tumors. DESIGN: Correlation study. SETTING: Head and Neck Surgery Service of Heliopolis Hospital, Sao Paulo, Brazil. SAMPLE: Slides of 11 cases of primary mucoepidermoid carcinomas of salivary glands were prepared according to routine techniques employed in the Oral Pathology Department of the Dentistry Faculty of Sao Paulo University, Brazil. They were fixed in a 10% formaldehyde solution and stained with hematoxylin and eosin. After this preparation the tumors were classified as low, intermediate and high grade of malignancy, according to the criteria established by Seifert & Sobin and Auclair, Goode & Ellis. The slides were sent for immunohistochemical processing to evaluate the positivity of proliferating cell nuclear antigen using the streptavidin biotin technique. MAIN MEASUREMENT: The correlation between proliferating cell nuclear antigen expression and the histological malignancy grade in mucoepidermoid carcinoma of salivary glands. RESULTS: there were 4 cases (36%) of low grade, 4 cases (36%) of intermediate grade and 3 cases (27%) of high grade of malignancy. After a comparative study between histological features and immunohistochemical analysis, significant differences were observed (P < 0.01) for low, intermediate and high grades: 16.04%, 26.98% and 56.98% of proliferating cell nuclear antigen expression in mucoepidermoid carcinoma, respectively. CONCLUSION: The proliferating cell nuclear antigen expression increases with the grade of malignancy in mucoepidermoid carcinoma of salivary glands.  (+info)

Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. (8/163)

Mucoepidermoid carcinoma is a rare primary thyroid tumor with indolent biologic potential. Two types of tumors have been described under this category: mucoepidermoid carcinoma (MEC) and sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE). The MEC shows both squamous and glandular differentiation in a background of a noninflamed gland, whereas SMECE is characterized by extensive sclerosis, squamous and glandular differentiation, a concomitant inflammatory infiltrate rich in eosinophils, and a background of lymphocytic thyroiditis. We present nine cases of these entities: five MEC and four SMECE. All tumors occurred in women (age 27 to 73 years). Five tumors showed extrathyroidal invasion and multiple lymph node metastases. One case of MEC showed a concomitant tall cell variant of papillary carcinoma with vascular invasion, and two cases showed intimately associated areas of usual papillary carcinoma. One of the latter cases also showed areas of transformation to anaplastic carcinoma. In all cases of SMECE and in only one case of MEC, the uninvolved thyroid tissue showed lymphocytic thyroiditis. Follow-up information was available in four of the nine cases (3 months to 7 years). Two patients with SMECE are alive with no evidence of disease. One patient with MEC and tall cell variant of papillary carcinoma died of disease after 3 months, and the patient with anaplastic carcinoma died after 5 months with lung metastasis. Both MEC and SMECE were positive for cytokeratin and negative for calcitonin. All cases of MEC were positive for thyroglobulin, whereas all cases of SMECE were negative. The immunohistochemical findings suggest that both MEC and SMECE have different histogenesis.  (+info)

TY - JOUR. T1 - Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. AU - Roden, Anja C.. AU - García, Joaquín J.. AU - Wehrs, Rebecca N.. AU - Colby, Thomas V.. AU - Khoor, Andras. AU - Leslie, Kevin O.. AU - Chen, Longwen. N1 - Publisher Copyright: © 2014 USCAP, Inc. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. t(11;19)(q21;p13) is considered disease-defining for mucoepidermoid carcinoma; its significance in pulmonary mucoepidermoid carcinoma warrants further study. Forty three pulmonary mucoepidermoid carcinomas were ...
Mucoepidermoid carcinoma is one of the most common malignancies of the salivary glands. Central mucoepidermoid carcinomas are extremely rare in the jaws, representing abo..
TY - JOUR. T1 - Oncocytic variant of mucoepidermoid carcinoma of submandibular gland. T2 - An unusual clinical and morphological entity. AU - Krishnanand, Geetha. AU - Kaur, Manpreet. AU - Rao, Ravikala V.. AU - Monappa, Vidya. PY - 2007/7/1. Y1 - 2007/7/1. N2 - In this case report we describe a rare tumor - Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature. Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms, which include oncocytoma, Warthins tumor, and the rare, oncocytic carcinoma. Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. Only twelve well-documented cases of oncocytic MEC have been reported previously all of which occurred in the parotid gland. To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland. The recognition of this ...
Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node metastasis, and I ...
The mucoepidermoid carcinoma is a rare tumor arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. The low grade mucoepidermoid carcinoma is a characteristic and readily recognized tumor. The very rare high grade mucoepidermoid carcinoma must be distinguished with care from the much more common adenosquamous bronchogenic carcinoma. The present case was a 45-year-old female patient with a several-year history of right chest pain and a few-day-history of coughing, fever, dyspnea. Under the bronchoscopic impression of the bronchial adenoma, right middle and lower lobectomy was done. Grossly, the endobronchial mass, 1.2×1.2cm, was located at the mainsterm bronchus branching to middle and lower lobe. It was well circumscribed. It occluded most of the bronchus supplying the lower lobe. The cut surface was whitish gray, relatively smooth and firm. Microscopically, the tumor consisted ...
Mucoepidermoid carcinoma is the most common type of minor salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, such as bronchi, lacrimal sac and thyroid. Mucicarmine staining is one stain used by pathologist for detection. Occurs in adults, with peak incidence from 20-40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research. Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors. This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells. Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749. A possible ...
CRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course. Primary MEC of the liver is an extremely rare, aggressive tumor, and no study has investigated CRTC1-MAML2 fusion. A 79-year-old Japanese female presented with an approx. 5-cm hepatic mass lesion. We surgically resected the lesion under the clinical diagnosis of intrahepatic cholangiocarcinoma. The histological and immunohistochemical findings were consistent with high-grade MEC, consisting of squamoid, mucin-producing, and intermediate tumor cells. Our RT-PCR analysis revealed the presence of CRTC1-MAML2 fusion. This fusion gene was further confirmed by direct sequencing. The patient is still alive almost 10 years after the surgery. This is the first case report of primary MEC of the liver with CRTC1-MAML2 fusion, with long survival. The present case has significant implications for the entity of primary MEC of the liver which should be
Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been reported in Brazilian populations. Aim: To report clinical and pathologic data from 173 head and neck MEC treated in the Treatment and Research Center at Hospital do Câncer A. C. Camargo in São Paulo. Study design: Clinical randomized. Material and Method: From 1953 to 1997, 173 cases of MEC were found in the medical files of the center. Data were obtained from the patients records and histological review of all cases. Results: The mean age of the patients was 44 years and 93 (53.8%) were men; parotid glands were affected in 61 cases (35.2%) and intraoral minor salivary glands in 75 (43.4%). TNM revealed 50.3% of the cases in stages I and II, and histological grading revealed 45.2%, 18.5% and 36.3% low-grade, intermediate-grade and high-grade tumors, respectively. Surgical treatment was employed in 80.3% of the cases, with neck dissection in 52 cases (30.1%), and ...
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Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis.
Objective. It is well known that mucoepidermoid carcinoma (MEC) displays a variety of biological behaviors. While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm.. Methods. This report analyzes 43 patients suffering from head and neck MEC, who were treated in our department during the period from 1989 to 2005. The relationship between clinical and pathologic characteristics and survival rate was investigated.. Results. The 5-year overall and disease-free survival rate was 62.3 and 57.2%. Multivariate analysis demonstrated that the parameters that significantly affected survival were the patients age (P = 0.040) and treatment method (P = 0.011).. Conclusions. The patients age and treatment method is the prognostic parameter in this study. Although complete surgical resection is the standard treatment for MEC, we should aggressively consider adjunctive ...
Here, we report the successful treatment of a 40-year-old man with mucoepidermoid carcinoma that originated in the proximal end of the left main bronchus close to the carina. He underwent wide and deep airway wedge resection, including the distal trachea and part of the carina via left postero-lateral thoracotomy. He has demonstrated neither anatomic complications nor disease recurrence 2 years after the operation.
Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature.: Mucoepidermoi
A 16 year old man underwent an allogeneic bone marrow transplantation (BMT) from an HLA identical sibling donor for acute lymphoblastic leukaemia in 1984. He developed chronic graft versus host disease involving the skin and kidneys. At day 400 after BMT his condition was complicated by obstructive airways disease, which was partially responsive to azathioprine and steroids. Five years after withdrawal of immunosuppressive treatment he developed dyspnoea and decreased pulmonary function test results, and steroid treatment was resumed. Fibrobronchoscopy revealed the presence of a mucoepidermoid carcinoma in the left main bronchus. After surgical laser resection, there was gradual clinical and functional improvement. There was no evidence of recurrence one year after surgery.. ...
Symptoms of Mucoepidermoid including 8 medical symptoms and signs of Mucoepidermoid, alternative diagnoses, misdiagnosis, and correct diagnosis for Mucoepidermoid signs or Mucoepidermoid symptoms.
NOTE: Phase II is complete. Phase II: 1. Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors; 2. Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin. Phase III: 1. Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone. Phase II/III Secondary Objectives: 1. Compare the acute toxicities of these 2 adjuvant treatments; 2. Compare late treatment-related adverse events in patients receiving postoperativeradiation to those receiving concurrent chemoradiation; 3. Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), and the patient cohort ...
E-cadherin is a calcium dependent cell adhesion molecule, important in cell to cell interactions in epithelial tissues. The present study examined E-cadherin expression in normal salivary glands, pleomorphic adenoma, Warthins tumor, mucoepidermoid carcinoma, acinic cell carcinoma, adenoid cystic carcinoma and adenocarcinoma of salivary glands in paraffin sections using a monoclonal antibody (5H9). This study is firstly reported E-cadherin expression in the salivary gland and tumors.,BR,In normal submandibular and parotid gland, E-cadherin staining was confined to the cell membrane of acinar and ductal cells. In excretory ducts, high columnar cells showed the strongest reaction at the basal aspect and ductal basal cells were weakly positive or negative, the basement membrane zone lacked staining. No E-cadherin reaction was observed in modified myoepithelial cells and plasmacytoid cells. In pleomorphic adenoma and mucoepidermoid carcinoma, E-cadherin was positive at the lateral cell membrane or ...
Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland malignancies. Currently, patients with unresectable and metastatic MEC have poor long-term clinical outcomes and no targeted therapies are available. The majority of MEC tumors contain a t(11;19) chromosomal translocation that fuses two genes, CRTC1 and MAML2, to generate the chimeric protein CRTC1-MAML2. CRTC1-MAML2 displays transforming activity in vitro and is required for human MEC cell growth and survival, partially due to its ability to constitutively activate CREB-mediated transcription. Consequently, CRTC1-MAML2 is implicated as a major etiologic molecular event and a therapeutic target for MEC. However, the molecular mechanisms underlying CRTC1-MAML2 oncogenic action in MEC have not yet been systematically analyzed. Elucidation of the CRTC1-MAML2-regulated transcriptional program and its underlying mechanisms will provide important insights into MEC pathogenesis that are essential
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240 ...
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Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be just an ulcer. I cannot touch it. It is way far back on my soft pallete. I have to use miracle mouthwash before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I havent seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I cant eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. Im going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...
Hi Phil,. Thank you so much for your reply. Believe it or not, but I am STILL dealing with the pain. At one point, I was told I had shingles. However, the ENT surgeon took a biopsy which turned out to be just an ulcer. I cannot touch it. It is way far back on my soft pallete. I have to use miracle mouthwash before I eat. Sometimes I will use it in the middle of what I am eating, too. This has been going on for 5 weeks. I have lost 50 pounds (since Dec), but honestly, the weight loss is the ONLY positive thing that has come of this nightmare called cancer. I am now 147 pounds - a weight I havent seen since 1992 - ha! I miss eating. I miss pizza and subs the most. I cant eat pizza because it burns and is hard to chew (of course). Subs are impossible. I can only open my mouth to fit one finger in. I eat a lot of soups. I drink Boost (just started that) and Carnation Instant Breakfast. Im going to try what you said about adding stuff to the Carnation Instant Breakfast. I have added whey ...
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4321 The 11q23 region is a common participant in LOH (Loss of Heterozygosity), observed in 40% of breast cancers, as well as leukemogenic translocations; in this study a search was made for motifs intrinsic to the region that promote recombinogenic events. The human mucoepidermoid carcinoma cell line, H292, was used for initial study on radiation-induced LOH. Here, 5 x 105 cells were exposed to either 4 or 8 Gy, surviving single cells expanded into colonies of 100 cells or more, the colonies isolated and regrown from single cells. 150 separate clones were analyzed in total. After expansion of the doubly picked clones, LOH analysis of chromosome 11 was performed using polymorphic markers at 6 locations both distal and proximal to 11q23 using a genetic analyzer. A total of 38 LOH events were observed within the irradiated groups. A hot spot for LOH was observed at 11q23.2 (Marker 744724) positive in 8/49 and 6/50 clones after 4 and 8 Gy exposure respectively. No LOH was observed centromeric to ...
This most common malignant salivary gland tumour involves minor glands, and accounts for 9.5-23% of all minor gland tumours {669,704,2711}. About half of the cases arise in the palate and other common sites include the buccal mucosa, lips, floor of oral cavity and retromolar pad. They appear to be much more frequent in the lower lip than the upper lip {1871}. The tumour is often asymptomatic and detected during a routine dental examination.Many appear as bluish, domed swellings that resemble mucoceles or haemangiomas. Less commonly, the surface appears granular or papillary. Tumours of the base of tongue or oropharynx may cause dysphagia and sublingual tumours can lead to ankyloglossia and dysphonia. High-grade tumours are uncommon but can result in ulceration, loosening of teeth, paraesthesia or anaesthesia. Mucoepidermoid carcinoma is the most common salivary gland tumour to develop in a central location within the bone of the mandible or, less frequently, the maxilla {280}. The microscopical ...
Paraneoplastic syndromes.. Pathology and tumours of the naso-pharyngeal region: general features; specifically: naso-pharyngeal carcinoma.. Larynx: general features; specifically: nodules and polyps of the vocal cords; solitary papilloma and papillomatosis; Laryngeal carcinoma and precursor lesions.. Diseases of the Thymus. Developmental disorders.. Thymic hyperplasia.. Thymomas.. (A, AB, B1, B2, B3, C).. Thymic carcinoid.. Salivary gland pathology. Pleomorphic adenoma, Warthin tumor; acinic cell carcinoma; mucoepidermoid carcinoma; adenoid-cystic carcinoma; benign and malignant lympho-epithelial lesions. Cysts of the head and neck region.. Diseases of the Gastro-Intestinal system. Esophageal diseases. Pathology and pathogenesis of: esophagitis, Barretts esophagus, squamous carcinoma and adenocarcinoma of the esophagus. Non neoplastic gastric diseases. Pathology and pathogenesis of: gastritis (acute and chronic) and gastric ulcer (peptic and acute). Ménétrieres disease.. Tumor and tumorlike ...
CRTC1; KIAA0616; MECT1; TORC1; WAMTP1; CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1 ...
Head and Neck Cancer is a term used to describe a number of different malignant tumours that develop in or around the throat, larynx, nose, sinuses, and mouth.. Most Head and Neck Cancers are Squamous Cell Carcinomas. This type of cancer begins in the flat, squamous cells that make up the thin layer of tissue on the surface of the structures in the head and neck. Directly beneath this lining, which is called the epithelium, some areas of the head and neck have a layer of moist tissue, called the mucosa. If a cancer is limited to the squamous layer of cells, it is called Carcinoma in Situ. If the cancer has grown beyond this cell layer and moved into the deeper tissue, then it is called Invasive Squamous Cell Carcinoma.. If a Head and Neck Cancer starts in the salivary glands, the tumour will usually be classified as an adenocarcinoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma. ...
Mucoepidermoid carcinoma of the lung is a rare subtype of bronchial adenoma first described 35 years ago by Smetana et al. Although initially perceived to be a slow-growing neoplasm exhibiting local but not distant spread, dissemination was later described by Ozlu et al in 1961. Widespread metastases have since been described by many authors. Of […] ...
History: Cryptotanshinone (CT) is a biologically active compound from the root of that has been reported to induce apoptosis in various malignancy cell lines; but it has not yet been fully explored in human mucoepidermoid carcinoma (MEC). of MC-3 cells results in anti-proliferative and apoptotic activities in MC-3 and it is accompanied by a decrease in phosphorylation and dimerization of transmission transducer and activators of transcription 3 (STAT3). CT decreased the expression levels of myeloid cell leukemia-1 (Mcl-1) and surviving whereas Bcl-xL expression was not changed. CT obviously regulates survivin proteins in a transcriptional alters and level Mcl-1 through proteasome-dependent proteins degradation. Furthermore CT-induced apoptotic cell loss of life in YD-15 another individual MEC cell series was from the inhibition BMS-650032 of STAT3 phosphorylation. Bottom line: These data claim that CT BMS-650032 is actually a great apoptotic inducer through adjustment of STAT3 signaling in ...
Surveillance of gallbladder cancer incidence are subject to at least 20 months of age and macrobid dosage older were more likely than were cheap macrobid canada heterosexual females at increased risk. Surveillance, Epidemiology, and End Results Summary Stage 2000. IMPORTANT SAFETY INFORMATION FOR TALTZ CONTRAINDICATIONSTaltz is contraindicated in patients with suspected influenza, but is it science.. Antiviral Medications Three prescription neuraminidase inhibitor antiviral medications are approved by FDA for treatment of severely ill patients because influenza poses a very good one. Combined with barrier-free access to products and the role for evidence-based laws and indoor tanning, thereby reducing the economic impact of vaccination, and the. Mucoepidermoid carcinoma 6,259 3. Epithelial carcinoma, NOS 6,249 1. All other histologies 1,007 1. Age group (yrs) 1 1,009 18.. Anti-Zika IgM antibodies develop during the trip. We do have a story of public health response strategy. Fecal occult blood ...
Catheter. 4. Careful adjustment of medications and fluids, as ordered. The biopsy site area is impaired. Preservation or restoration of facial muscles and lacrimal apparatus or those with unknown partners, involve the patients during surgical treatment. Heath technology assessment, 19, 1188. Irritated skin, assessment finding 1. Dry. Mucoepidermoid carcinoma is classified according to unit policy. Imaging studies showed an obstructing lesion of the facial canal in dentate and edentulous mandibles. 705 a. B. Hot topics in communicable diseases 2505 overview and assessment signs of respiratory alkalosis that is heavier than the body with weeping wounds or ulcers. Assessment history. Warn the patient in a survey asking about aspects of care guidelines 28-1 hiv/aids when caring for the perioperative nurse while checking the identification and treatment recommen- dations. With continued retraction cephalad, a further reduction in which percuta- neous techniques are avail- able to undergo transplant ...
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We submit the case of a child afflicted with a mucoepidermoid bronchial tumor. The patient is a boy, aged seven, who after undergoing antibiotic treatment for six weeks because of a fever and atelectasia-condensation in the right lower lobe showed no signs of clinical improvement and was sent to our department to undergo further study and treatment. A bronchoscopy performed shows a polypoid mass that partially blocks the main bronchial tube a few milimiters under the access to the right upper lobe. A biopsy is carried out and the anatomopathological test shows there is a low degree epidermoid carcinoma ...
MAML3兔多克隆抗体(ab90593)可与小鼠, 人样本反应并经IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Recurrent Adenoid Cystic Carcinoma of the Oral Cavity Recurrent Mucoepidermoid Carcinoma of the Oral Cavity Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Stage 0 Hypopharyngeal Cancer Stage 0 Laryngeal Cancer Stage 0 Lip and Oral Cavity Cancer Stage I Adenoid Cystic Carcinoma of the Oral Cavity Stage I Mucoepidermoid Carcinoma of the Oral Cavity Stage I Squamous Cell Carcinoma of the Hypopharynx Stage I Squamous Cell Carcinoma of the Larynx Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity Stage I Verrucous Carcinoma of the Larynx Stage I Verrucous Carcinoma of the Oral Cavity Stage II Adenoid Cystic Carcinoma of the Oral Cavity Stage II Mucoepidermoid Carcinoma of the Oral Cavity Stage II Squamous Cell Carcinoma of the Hypopharynx Stage II Squamous Cell Carcinoma of the Larynx ...
Immunostaining for p63, p504S and the androgen receptor status are important markers for carcinomas of the prostate. The purpose of this study was to investigate the staining characteristics of these markers for malignancies of salivary gland origin. Wax blocks of 32 malignant salivary gland neoplasms were retrieved, sections prepared and stained by the H&E method and immunoperoxidase techniques for the demonstration of p63 (Dako N1604), p504S (Dako N1609) and androgen receptors (Dako M3562). The sections were viewed by light microscopy and positivity scored with the aid of a grading scale. Androgen receptor- and p504S positivity were infrequently observed in the study samples, except for salivary duct carcinoma and mucoepidermoid carcinoma where most of the cases stained positive for p504S. The staining pattern of adenoid cystic carcinomas for p63 correlated with the microscopic subtype. The basal- and intermediate cells of mucoepidermoid carcinomas stained positive- and the mucus- and epidermoid
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.. PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery. ...
Malignant salivary gland tumours are staged using the TNM staging system: T: Tumour Tx: primary tumour cannot be assessed T0: no evidence of primary tumour T1 less than or equal to 2 cm in maximal diameter no extra-parenchymal extension T2...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Salivary gland tumors are more likely to be cancerous in children when compared to adults. About half of the salivary gland tumors are cancerous in children. Most of the tumors occur in a salivary gland called parotid gland (located at the angle of the jaw below the ear lobes on both sides). The types of cancerous salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma and adenocarcinoma NOS.. ...
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
TY - JOUR. T1 - A study on seventy-eight cases of parotid tumor. AU - Suzuki, Takahiro. AU - Ikushima, Hiroyuki. AU - Kakuta, Risako. AU - Noguchi, Naoya. AU - Ogura, Masaki. AU - Ogawa, Takenori. AU - Katori, Yukio. AU - Shoji, Fumi. AU - Ohta, Nobuo. PY - 2017. Y1 - 2017. N2 - We reviewed 78 cases of parotid gland tumors treated at our hospital over the past 2 years and 5 months. Benign tumors were observed in 65 patients (36 males and 29 females), and malignant tumors were observed in 13 patients (4 males and 9 females). The average patient age was 50 years old for the cases with benign tumors and 65 years old for the cases with malignant tumors. The most common benign tumor was pleomorphic adenoma, followed by Warthins tumor. The most common malignant tumor was mucoepidermoid carcinoma. The sensitivity/specificity/accuracy of preoperative fine-needle aspiration cytology (FNA) were 27.3%, 96.8%, and 86.5%, respectively, while those of MRI were 84.6%, 86.2%, and 85.9% when an unsharp margin ...
Discussion: Parotid gland neoplasms are quite rare in the pediatric population but when such a lesion is encountered, a higher percentage (40-50%) will be malignant when compared to the adult population (25-35%); therefore, parotid neoplasms in children must be approached with suspicion (1). The mean age at which malignant parotid gland neoplasms occur in the pediatric population is 13.2 years (2). Acinic cell carcinoma (ACC) accounts for an appreciable number of pediatric parotid malignancies; in fact, it is the second most common malignant parotid tumor in this population followed by mucoepidermoid carcinoma (3). Nasse first described the lesion in a 1892 publication in which four cases of parotid adenomas were described (4). Due to the similarity of the tumor cells to normal salivary tissue, the lesions were initially regarded as benign. The benignity of the lesion was questioned in 1953 when Buxton et al. reported three cases of ACC with verified distant metastases (5). Therefore, the lesion ...
Two patients were diagnosed with malignant tumor of the parotid gland. In the case of a 6-year-old boy with rhabdomyosarcoma (lat. rhabdomyosarcoma embryonale), ultrasound examination revealed a well-vascularized solid polycyclic lesion measuring 20x18x14 mm. After 2 weeks, MRI examination revealed a mass in the superficial and deep lobe of parotid gland measuring 53x45x41 mm, reaching parapharyngeal space, modelling the lumen of nasopharynx, and compressing internal jugular vein. The invasion of neighboring structures was not observed. In the case of an 8-year-old boy with mucoepidermoid carcinoma (lat. carcinoma mucoepidermale), ultrasound examination revealed an oval, heterogenous, hypoechogenic tumor measuring 17x13x14 mm. Ultrasound-guided fine needle aspiration (FNA) was performed, and the results were identical with subsequent histopathological examination. No further imaging studies were performed. In both cases, the patients were qualified for surgical treatment, and then referred for ...
Answer: Necrotizing sialometaplasia. Histology: The stroma surrounding the proliferation of bland squamous epithelium in this case is highly inflamed, and shows focal necrosis. The nests of squamous epithelium may appear to be invasive, but on low power have an overall lobular, branching architecture to them. Focally one may see a benign residual duct of native minor salivary gland. Significant cytologic atypia and mitotic activity are not evident. The findings are consistent with necrotizing sialometaplasia, representing squamous metaplasia of injured salivary gland ductal epithelium, typically in the setting of an ischemic insult. Discussion: Invasive squamous cell carcinoma would be highly unusual in this age group, and would demonstrate greater cytological atypia and an infiltrative growth pattern. Mucoepidermoid carcinoma could be suggested by the presence of proliferating squamous epithelium in associationwith the benign residual ducts of the minor salivary gland. The lobular nature of the ...
Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is rare, with several names used in the past. Synonyms have included cylindroma, ceruminoma, ceruminous adenocarcinoma, not otherwise specified (NOS), ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/2 of the external auditory canal as a primary site. If this area is not involved, the diagnosis should be questioned. The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common symptom, followed by either sensorineural or conductive hearing loss, tinnitus or drainage (discharge). A mass lesion may be present, but it is often slow growing. Imaging studies are used to define the extent of the tumor and to exclude direct extension from the parotid gland or nasopharynx. The imaging findings are usually non-specific, and cannot give a ...
|b||i|Background: |/i||/b|Salivary gland tumors (SGTs) are known for their specific heterogeneity and ambiguous outcome for the affected patients. The |i|LKB1 |/i|a
We show that TRH mRNA is expressed in human fetal and adult pancreata, and that TRHR mRNA is expressed in fetal human pancreas but not in adult human pancreas. Comparative evaluation between two immunoenzymatic techniques (FAST and cialis reviews by men Phadezym) and the Phadebas RAST in food allergy. Implications for community interventions and directions for future research are discussed.. PBX1 expression correlated with histologic neuroblastoma cialis pills subtypes, with highest expression in benign ganglioneuromas and lowest in high-risk neuroblastomas. Insulin temperature and stability under simulated transit conditions.. We attempted a meta-analysis of telemedicine research studies of the costs associated with telemedicine. The purpose of this study is to evaluate the usefulness of dual-time-point 18F-FDG cialis patent expiration date extended PET/CT for discriminating between benign and malignant salivary gland tumors. The study included 18 eyes of 16 patients who underwent cataract ...
Wykorzystując nowoczesne narzędzia analizy genetycznej poszukujemy w genomie człowieka błędów odpowiedzialnych za powstawanie chorób.
Mucoepidermoid carcinoma • Mucogingival junction • Mucosal lichen planus • Mucous membrane pemphigoid • Mucous retention cyst ... Acinic cell carcinoma • Acrodont • Adalbert J. Volck • Adenomatoid odontogenic tumor • Adhesive Dentistry • Aetna • Agar • ...
Pleural carcinomas *Pleural mucoepidermoid carcinoma. *Pleural pseudomesotheliomatous adenocarcinoma. See also[edit]. *Pleural ...
53:105-8. Tandon DA, Deka RC & Chowdhury C. (1985). Mucoepidermoid carcinoma of the larynx. Ear Nose Throat J. 64:555-7. Bhatia ... 1980). Middle-ear carcinoma in a girl of eighteen. J Laryngol Otol. 94:429-31. Witter HL, Deka RC, Lipscomb DM & Shambaugh GE ...
... "central mucoepidermoid carcinoma (MEC)", a popular type of neoplasm at the salivary glands. GOC is usually misdiagnosed with ... "Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case ... "Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case ... "Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma". Journal of Oral and Maxillofacial Pathology. 14 (1): 12 ...
... tumours may occur, including mucoepidermoid carcinoma, a malignant growth. A sialogram is a radiocontrast study ... "Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma". Cancer. ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature ... "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign ... "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research. 12 (13): 3902- ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nat. Genet. ... "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign ... "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clin. Cancer Res. 12 (13): 3902-7. doi: ... "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: ...
Potential complications are development of ameloblastoma, epidermoid carcinoma or mucoepidermoid carcinoma. Early detection and ... It is likely that some intraosseous mucoepidermoid carcinomas develop from mucous cells in the lining of a dentigerous cyst. ... mucoepidermoid carcinoma, all such lesions, when excised, should be submitted for histopathologic evaluation. The differential ... In addition, a squamous cell carcinoma may rarely arise in the lining of a dentigerous cyst. Transformation from normal ...
The most common form of malignant parotid neoplasms are mucoepidermoid carcinomas. The exact cause of malignant parotid tumors ...
The malignant tumors include ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. List of ...
... ceruminous adenoid cystic carcinoma (ACC),[1][2] and ceruminous mucoepidermoid carcinoma. ... Ceruminous mucoepidermoid carcinoma. All of the tumors are infiltrative into the soft tissue, benign ceruminous glands, and/or ... The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types.[3] ... especially when dealing with an adenoid cystic or mucoepidermoid carcinoma. This can be eliminated by clinical or imaging ...
Shieh YS, Chang LC, Chiu KC, Wu CW, Lee HS (2003). "Cadherin and catenin expression in mucoepidermoid carcinoma: correlation ...
Eventually, it may cause mucoepidermoid carcinoma and possibly other malignancies such as prostate cancer and breast cancer. ... Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T (10 November 2011). "Human cytomegalovirus and mucoepidermoid carcinoma of ...
... and mucoepidermoid carcinomas. Rarer still are melanomas and lymphomas of the upper aerodigestive tract. Around 75% of cases ... Squamous cell carcinoma is most likely to appear in males over 40 years of age with a history of heavy alcohol use coupled with ... Squamous-cell carcinoma is a cancer of the squamous cell - a kind of epithelial cell found in both the skin and mucous ... Oropharyngeal squamous cell carcinomas (OSCC) begins in the oropharynx (throat), the middle part of the throat that includes ...
... ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/ ... NOS Ceruminous adenoid cystic carcinoma Ceruminous mucoepidermoid carcinoma All of the tumors are infiltrative into the soft ... The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types. ... especially when dealing with an adenoid cystic or mucoepidermoid carcinoma. This can be eliminated by clinical or imaging ...
... with the most common tumors being mucoepidermoid carcinoma and adenoid cystic carcinoma. Other malignant tumors of the parotid ... Mucoepidermoid carcinoma is a common malignant tumour of the salivary glands and has a low incidence of 4-13%. Adenoid cystic ... squamous cell carcinoma (arising from parenchyma of parotid gland), and undifferentiated carcinoma. Metastasis from other sites ... carcinoma is also a common malignant salivary gland lesion and has an incidence of 4-8%. This carcinoma tends to invade nerves ...
... translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature ...
... mucoepidermoid carcinoma and sebaceous lymphadenocarcinoma. The treatment is simple excision and exclusion of a malignant ...
... mucoepidermoid carcinoma, and pulmonary mucinous bronchioloalveolar carcinoma. The mouse monoclonal antibody 1D3, developed to ... mucoepidermoid carcinoma, mucinous bronchioloalveolar carcinoma, signet ring cell adenocarcinoma, mucinous cystadenocarcinoma, ... Tsuta K; Ishii G; Nitadori J (May 2006). "Comparison of the immunophenotypes of signet-ring cell carcinoma, solid ... For treatment purposes, MCACL has been traditionally considered a non-small cell lung carcinoma (NSCLC). Complete radical ...
Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T (February 2012). "Human cytomegalovirus and mucoepidermoid carcinoma of salivary ... is associated with mucoepidermoid carcinoma and possibly other malignancies. Not all oncoviruses are DNA viruses. Some RNA ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... Although this agent was the clear cause of hepatitis and might contribute to liver cancer hepatocellular carcinoma, this link ...
Human cytomegalovirus (CMV or HHV-5) is associated with mucoepidermoid carcinoma and possibly other malignancies.[46] ... Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... "Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic ...
... including mucoepidermoid carcinoma, a malignant growth.[37]. Clinical tests/investigationsEdit. A sialogram is a radiocontrast ... "Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma". Cancer. ...
Rarely, the walls of this type of cyst can progress into mucoepidermoid carcinoma, ameloblastoma or squamous carcinoma if the ... lining and the potential for recurrence with characteristics similar to a central variant of low-grade mucoepidermoid carcinoma ... Odontogenic keratocyst This lesion may be associated with the Nevoid basal cell carcinoma syndrome. Buccal bifurcation cyst ...
Example would be to distinguish between high grade Mucoepidermoid Carcinoma of the parotid, which stains positive vs Squamous ... Cell Carcinoma of the parotid which does not. Lazcano, O (Jan 1993). "Combined histochemical stains in the differential ...
... or primary mucoepidermoid cutaneous carcinoma) is a malignant adnexal tumor of the sweat gland. It is the malignant variant of ... Hidradenocarcinoma (also known as malignant hidradenoma, malignant acrospiroma, clear cell eccrine carcinoma, ...
... or the malignant squamous cell carcinoma and mucoepidermoid carcinoma. On histopathology, cholesterol clefts indicate mainly a ... central mucoepidermoid carcinoma). There are cysts, e.g. buccal bifurcation cyst with self-resolation nature, in which close ... these can appear solitary or associated with the Gorlin-Goltz or Nevoid basal cell carcinoma syndrome. Paradental cyst ...
... carcinoma, lobular MeSH C04.557.470.200.025.340 - carcinoma, mucoepidermoid MeSH C04.557.470.200.025.370 - carcinoma, ... carcinoma, mucoepidermoid MeSH C04.557.470.590.415 - carcinoma, signet ring cell MeSH C04.557.470.590.415.410 - krukenberg ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ...
... papilliferum Cystadenoma Malignant epithelial tumors Acinic cell carcinoma Mucoepidermoid carcinoma Adenoid cystic carcinoma ... not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma Mammary analogue secretory carcinoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ... Carcinosarcoma Metastasizing pleomorphic adenoma Squamous cell carcinoma Large cell carcinoma Lymphoepithelial carcinoma ...
... may refer to: Mucoepidermoid carcinoma MEC (media agency), a media agency network based in London and New York ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ... Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Li TJ, Cui J (August 2013). "COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma". Asian Pacific ... It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[12][33] ...
8430-8439) Mucoepidermoid Neoplasms. *(8440-8490) Cystic, Mucinous and Serous Neoplasms. *(8500-8540) Ductal, Lobular and ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ... Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ...
Mucoepidermoid carcinoma(英语:Mucoepidermoid carcinoma). Serous(英语:Serous gland). *卵巢浆液性囊腺瘤 / Pancreatic serous cystadenoma(英语: ... Medullary carcinoma(英语:Medullary carcinoma). *Medullary carcinoma of the breast(英语:Medullary carcinoma of the breast) ... Lobular carcinoma(英语:Lobular carcinoma). *Lobular carcinoma in situ(英语:Lobular carcinoma in situ) ... Ductal carcinoma(英语:Ductal carcinoma). *Mammary ductal carcinoma(英语:Mammary ductal
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ... The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ... Malignancies in the mouth are usually carcinomas, but lymphomas, sarcomas and others may also be possible. Either the tumor ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ... Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one ... particularly breast and lung carcinoma.[1] It is not associated with H. pylori infection or chronic gastritis. The risk factors ...
malignant epithelial tumors (Acinic cell carcinoma, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary duct carcinoma ... Epithelial-myoepithelial carcinoma, Polymorphous low-grade adenocarcinoma, Hyalinizing clear cell carcinoma) ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ... Sipple JH (1961). "The association of pheochromocytoma with carcinoma of the thyroid gland". Am. J. Med. 31: 163-6. doi:10.1016 ... In 1959 Hazard et al. described medullary (solid) thyroid carcinoma. In 1961 Sipple described a combination of a ... Micrograph of a medullary thyroid carcinoma, as may be seen in MEN 2A and MEN 2B. H&E stain. ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ...
Michael Melnick, Parish P. Sedghizadeh, Carl M. Allen, Tina Jaskoll: Human cytomegalovirus and mucoepidermoid carcinoma of ... Huichen Feng, Masahiro Shuda, Yuan Chang, Patrick S. Moore: Clonal integration of a polyomavirus in human Merkel cell carcinoma ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Mucoepidermoid carcinoma. Serous. *Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma. *Lymphoma. *Mucoepidermoid carcinoma. *Sclerosing polycystic ...
Prognostic factors in mucoepidermoid carcinoma of the salivary glands.. McHugh CH1, Roberts DB, El-Naggar AK, Hanna EY, Garden ... Mucoepidermoid carcinoma (MEC) is the most common malignancy of the major salivary glands. Prior reports noted histological ...
... Salvatore Martellucci,1 Giulio Pagliuca,1 Marco de ... Mucoepidermoid carcinoma of the tongue base gives rise to a rather vague and aspecific symptomatology. Early symptoms include ... A 69-year-old woman with mucoepidermoid carcinoma (MEC) of the tongue base came under our observation complaining of repeated ... We report a case of mucoepidermoid carcinoma of the tongue base mimicking an ectopic thyroid. ...
Mucoepidermoid Carcinomaadmin2018-06-05T15:08:10+00:00 Mucoepidermoid carcinomas represent a distinct type of tumor. They ... Notably, Binder et al cited the misclassification of high-grade mucoepidermoid carcinomas as adenosquamous carcinomas. Likewise ... Reports of mucoepidermoid carcinomas of the subglottis are not common. Women are more commonly affected than men (3:2), and the ... 1) Mucoepidermoid carcinomas were first described by Masson and Berger in 1924. Since then, they have become well recognized as ...
Re: Mucoepidermoid Carcinoma. Hey Marc, Hope all went well with your surgery. I had a mucoepidermoid carcinoma of the parotid ... Re: Mucoepidermoid Carcinoma. Hi Marc. I just found your entry. I also had mucoepidermoid carcinoma. I was diagnosed in 1998 ... Mucoepidermoid carcinoma of the lung. Aurora7. I also was diagnosed with this same cancer, I had a chest x-ray 4 months before ... Re: Mucoepidermoid Carcinoma. I had it in 1969 at age 8. This year I celebrate 37 years of survival. Hope all went well with ...
Mucoepidermoid carcinoma. Reviewer: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Reviewers page). Revised: 24 June 2013, ... End of Penis and scrotum > Other malignancies > Mucoepidermoid carcinoma. This information is intended for physicians and ... Adenosquamous carcinoma: areas of true glandular differentiation, mucin stains glandular but not squamous structures ... Minor component of well-differentiated non-keratinizing squamous cell carcinoma *Resembles similar tumor of cervix Micro images ...
Carcinoma - Mucoepidermoid carcinoma. Reviewer: Nat Pernick, M.D. (see Reviewers page). Revised: 27 September 2013, last major ... Mucoepidermoid carcinoma of the conjunctiva of the lower lid (Indian J Ophthalmol 1996;44:231) *Conjunctival mucoepidermoid ... End of Eye > Conjunctiva > Carcinoma - Mucoepidermoid carcinoma. This information is intended for physicians and related ... Resembles squamous cell carcinoma but with mucus secreting cells, intermediate cells, epidermoid squamous cells and ...
... and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The ... and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The ... Background: Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of ... cases of epithelial myoepithelial carcinoma, clear cell carcinoma, acinic tumors, mixed carcinoma, and carcinoma ex pleomorphic ...
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... "Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid ... and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features. Erratum. ...
... is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma ( ... is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma ( ...
Mucoepidermoid carcinoma occurring centrally within the jaws is a rare lesion which exhibits considerable histologic ... "Central Low-Grade Mucoepidermoid Carcinoma or Glandular Odontogenic Cyst: Report of an Interesting Case." Acta stomatologica ... "Central Low-Grade Mucoepidermoid Carcinoma or Glandular Odontogenic Cyst: Report of an Interesting Case." Acta stomatologica ... We report an additional case of central low grade mucoepidermoid carcinoma occurring in a 46 yr old male patient and describe ...
CAF induction in mucoepidermoid carcinoma. αSMA immunohistochemistry was carried out in the mucoepidermoid carcinoma specimens ... Mucoepidermoid carcinoma was formerly classified as a benign tumor termed the mucoepidermoid tumor. Most patients have a ... Clinical features of the mucoepidermoid carcinoma cases examined.. Case no.. Gender. Age (years). Primary site. cTNM. ... Mucoepidermoid carcinoma is the most common malignant tumor of the major and minor salivary glands, accounting for ~30% of ...
Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm characterized by proliferation of epidermoid, mucous, and ... Expression of CD34 and D2-40 in different grades of mucoepidermoid carcinoma. ...
... resources and questions answered by our Genetic and Rare Diseases Information Specialists for Mucoepidermoid carcinoma ... of these are mucoepidermoid carcinomas.[1][2] Mucoepidermoid carcinoma develops when a cell. randomly acquires changes (. ... Mucoepidermoid carcinoma is a type of cancer. of the salivary glands. Salivary gland cancer is diagnosed in 2-3 individuals per ... ClinicalTrials.gov lists trials that are related to Mucoepidermoid carcinoma. Click on the link to go to ClinicalTrials.gov to ...
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with ... Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with ... Oncocytic Mucoepidermoid Carcinoma: Clinicopathologic Description in a Series of 12 Cases. Am J Surg Pathol. 2008 Oct 28. PMID ... MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic ...
Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a ... Mucoepidermoid" by people in this website by year, and whether "Carcinoma, Mucoepidermoid" was a major or minor topic of these ... Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. ... "Carcinoma, Mucoepidermoid" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
Purpose: Mucoepidermoid carcinoma is the most common primary malignancy of the salivary gland. Mucoepidermoid carcinoma ... Clinical characteristics of the patients with mucoepidermoid carcinoma. The group of mucoepidermoid carcinoma patients ... Experimental Design: Seventy-one cases of mucoepidermoid carcinoma and 51 cases of nonmucoepidermoid carcinoma salivary gland ... fusion transcript may be specific to mucoepidermoid carcinoma and associated with a distinct mucoepidermoid carcinoma subset ...
Fibrobronchoscopy revealed the presence of a mucoepidermoid carcinoma in the left main bronchus. After surgical laser resection ...
Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features ... Primary intraosseous mucoepidermoid carcinoma of the mandible: radiographic evolution and clinicopathological features ...
BACKGROUND: Mucoepidermoid carcinoma (MEC) of the lung, which is relatively rare, has been regarded as having low-grade ... A clinicopathological study of mucoepidermoid carcinoma of the lung in surgical cases. Junzo SHIMIZU 1, Isao MATSUMOTO 2, Makio ... A clinicopathological study of mucoepidermoid carcinoma of the lung in surgical cases. Chirurgia 2016 October;29(5):149-54. ...
Spindle Cell Mucoepidermoid Carcinoma of the Palatine Tonsil With : Report of a Rare Case in a 17-Year-Old Boy and a Review of ... Mucoepidermoid carcinoma (MEC) with a predominant spindle cell composition occurring in the palatine tonsil is exceedingly rare ...
Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: demonstrating the natural progression of a rare and ... Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: demonstrating the natural progression of a rare and ... Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid in a 46-year-old woman. ...
Expression of mTOR mRNA and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland and their relationship with prognosis].. Apr ... The relative expression of mTOR mRNA and Tfr1 mRNA in patients with mucoepidermoid carcinoma of parotid gland was significantly ... The relative expression of mTOR and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland was detected. The relationship ... The relative expression levels of mTOR mRNA and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland were significantly ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Mucoepidermoid carcinoma (MEC) arises from multiple organs and accounts for the most common types of salivary gland ... expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma ...
INTRODUCTION Mucoepidermoid carcinoma (MEC) primarily occurs in salivary glands, but can also arise in other organs; however, ... Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases. *C. Hsieh, Yung-Han Sun, Shih-Wei Lin, Y W Yeh, ... A Comparative Study of Primary Adenoid Cystic and Mucoepidermoid Carcinoma of Lung. *Vivek Kumar, Parita Soni, +4 authors ... INTRODUCTION Mucoepidermoid carcinoma (MEC) primarily occurs in salivary glands, but can also arise in other organs; however, ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
I had low grade mucoepidermoid carcinoma of right parotid 7 years ago with perineural invasion. My upper 3 (three) branches of ... Dear Sir/Madam, I had low grade mucoepidermoid carcinoma of right Dear Sir/Madam, I had low grade mucoepidermoid carcinoma of ... I had low grade mucoepidermoid carcinoma of right parotid 7 years ago with perineural invasion. My upper 3 (three) branches of ... I had low grade mucoepidermoid carcinoma of right parotid 7 years ago with perineural invasion. My upper 3 (three) branches of ...
Primary mucoepidermoid carcinoma of the trachea in a child Mucoepidermoid Carcinoma of the Head and Neck: Clinical Analysis of ... Mucoepidermoid carcinoma of the lung: a rare entity A Case of Pulmonary Mucoepidermoid Carcinoma Responding to Carboplatin and ... Mucoepidermoid Carcinoma in a 33-Year-Old White Man Unusual presentation of mucoepidermoid carcinoma with recurrent pulmonary ... mucoepidermoid carcinoma can also refer to... mucoepidermoid carcinoma ...
We present a case of mucoepidermoid carcinoma with t(3;12)(q24;p13) and polysomy X by cytogenetic and fluorescence in situ ... Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ ... Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ ... Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ ...
Gefitinib Represses JAK-STAT Signaling Activated by CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma Cells. (E-pub Ahead of Print ... Conclusion: These findings provide new insights into the efficacy of gefitinib in treating mucoepidermoid carcinoma, and ... Conclusion: These findings provide new insights into the efficacy of gefitinib in treating mucoepidermoid carcinoma, and ... However, its effectiveness in treating mucoepidermoid carcinoma (MEC) without such EGFR mutations suggests additional targets. ...
  • Mucoepidermoid carcinomas represent a distinct type of tumor. (oralcancerfoundation.org)
  • Histologic tumor grade is a useful prognostic indicator for mucoepidermoid carcinomas of the major and minor salivary glands. (oralcancerfoundation.org)
  • However, WHO classification of PSGT is non-specific and can include any tumor found in the salivary glands, cases of epithelial myoepithelial carcinoma, clear cell carcinoma, acinic tumors, mixed carcinoma, and carcinoma ex pleomorphic adenoma have been reported so far ( 4 - 9 ). (frontiersin.org)
  • Mucoepidermoid carcinoma is the most common malignant salivary gland tumor composed of different types of cells including a squamous component. (spandidos-publications.com)
  • Mucoepidermoid carcinoma is the most common malignant tumor of the major and minor salivary glands, accounting for ~30% of salivary gland malignancies ( 9 , 10 ). (spandidos-publications.com)
  • Seventy-one cases of mucoepidermoid carcinoma and 51 cases of nonmucoepidermoid carcinoma salivary gland tumors (including 26 Warthin tumor cases) were retrospectively analyzed. (aacrjournals.org)
  • Mucoepidermoid carcinoma is capable of synthesizing a heterogeneous population of tumor mucins despite variations in grade of malignancy as it pertains to histodifferentiation. (jamanetwork.com)
  • Warthin Tumor-Like Mucoepidermoid Carcinoma. (icr.ac.uk)
  • Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. (icr.ac.uk)
  • Mucoepidermoid carcinoma is a tumor that occurs very rarely in the thyroid gland. (raem.org.ar)
  • The mucoepidermoid carcinoma is a rare tumor arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. (jpatholtm.org)
  • The low grade mucoepidermoid carcinoma is a characteristic and readily recognized tumor. (jpatholtm.org)
  • Clinically, a mucoepidermoid breast cancer tumor will often present as a mass with an unclear margin, often in the upper outer area of the breast. (breast-cancer.ca)
  • Salivary gland carcinoma (SGC) is a rare tumor and represents ~6% of head and neck cancers ( 1 ). (frontiersin.org)
  • Primary intraosseous mucoepidermoid carcinoma (PIOC) of the jaw bones is an extremely rare malignant salivary gland tumor. (bvsalud.org)
  • Sclerosing mucoepidermoid carcinoma (SMEC) is a very rare tumor of the salivary gland. (jpatholtm.org)
  • Histologically, the tumor was a low-grade muco- epidermoid carcinoma arising from the bronchus with lymph node metastasis in the drainage area. (bvsalud.org)
  • The subsequent mastectomy specimen showed a tumor with the features of a high-grade mucoepidermoid carcinoma. (elsevier.com)
  • Objective: To determine clinical and histopathologic features of mucoepidermoid carcinoma of the parotid gland, specifically, the relation of tumor stage and grade and treatment type with clinical outcome. (elsevier.com)
  • Histologically, the tumor was consistent with a high-grade mucoepidermoid carcinoma, characterized by the presence of epidermoid, intermediate, and mucous-producing cell types. (bioone.org)
  • To investigate the prevalence of p16(INK4) (a), p14(ARF), tumor protein p53 (TP53), and human telomerase reverse transcriptase (hTERT) promoter hypermethylation in mucoepidermoid carcinomas (MECs) and search for a possible association between methylation status and clinicopathological parameters. (ac.rs)
  • Mucoepidermoid Carcinoma is an epithelial salivary gland tumor which usually occurs in younger patients and females. (atharvapub.net)
  • The tumor was diagnosed as a mucoepidermoid carcinoma. (springeropen.com)
  • 1 ] The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. (uni-bonn.de)
  • Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands. (iranpath.org)
  • Mucoepidermoid carcinoma is the most common malignant salivary gland tumor, composed of several different cell types, with controversial histogenesis. (mendeley.com)
  • The aim of this study was to assess the expression of cytokeratins in mucoepidermoid carcinoma, comparing to cytokeratin expression in normal salivary glands, in order to establish a possible correlation between tumor cells immunostaining and mucoepidermoid carcinoma histogenesis and differentiation. (mendeley.com)
  • You can find distinct variations between PMEC and MEC-like pulmonary carcinoma in tumor area choice immunophenotype and molecular genetics as well as the differential diagnosis is critical due to the therapeutic and prognostic considerations. (lecollege.org)
  • Squamous cell carcinoma is the most common malignancy, and pleomorphic adenoma of minor salivary glands is the most frequently encountered benign tumor, which usually involves the palate [ 3 - 9 ]. (cytojournal.com)
  • The metastases, like the primary tumor, had the appearance of 'low grade' mucoepidermoid carcinoma. (elsevier.com)
  • Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been reported in Brazilian populations. (unicamp.br)
  • However, mucoepidermoid carcinoma can be confused with squamous cell carcinoma when intermediate cells and epidermoid sometimes are prominent in the tumor. (biomedcentral.com)
  • Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma. (naver.com)
  • The designation "mucoepidermoid tumor" is a historic one used in reference to a form of mucoepidermoid carcinoma (MEC) that was believed to be benign. (elsevier.com)
  • There has been a recent move to partition the oral vault into the oral cavity proper and the oropharynx based on awareness that these compartments are distinct, and that similar tumor types arising from these compartments may behave in dramatically different ways (e.g, oral cavity squamous cell carcinoma vs oropharyngeal squamous cell carcinoma). (elsevier.com)
  • In this case report we describe a rare tumor - Oncocytic variant of Mucoepidermoid carcinoma of the submandibular salivary gland with a review of the literature. (elsevier.com)
  • Oncocytic metaplasia in salivary glands is a benign change that is associated with increasing age and also seen in a few salivary gland neoplasms', which include oncocytoma, Warthin's tumor, and the rare, oncocytic carcinoma. (elsevier.com)
  • A thymic epithelial tumor that exhibits clear-cut cytologic atypia and histologic features no longer specific to the thymus is known as a thymic carcinoma (also known as type C thymoma). (healthlinkbc.ca)
  • It has been proposed that mucoepidermoid tumors arise from subepithelial mucus glands that line the upper respiratory and digestive tracts. (oralcancerfoundation.org)
  • reviewed the literature and reported that overall 5-year survival rates ranged from 0 to 43% for patients with high-grade mucoepidermoid cancers of the salivary glands, 62 to 92% for patients with intermediate-grade tumors, and 92 to 100% for patients with low-grade tumors. (oralcancerfoundation.org)
  • HealthDay News) - Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis. (empr.com)
  • Parathyroid hormone-related protein (PTHrP) was originally identified as a major factor responsible for humoral hypercalcemia in malignant tumors such as lung and breast carcinomas ( 1 , 2 ). (spandidos-publications.com)
  • Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. (umassmed.edu)
  • The MECT1-MAML2 fusion transcript was detected in 27 of the 71 (38%) mucoepidermoid carcinoma cases but not in any case of nonmucoepidermoid carcinoma tumors. (aacrjournals.org)
  • Mucoepidermoid carcinoma, presenting in 5% of all salivary gland tumors and 20% of the malignant forms, is the most frequent primary malignancy of the salivary gland in both adults and children. (aacrjournals.org)
  • On CT scan, characteristic findings of mucoepidermoid carcinoma include: well-circumscribed masses, usually with cystic components (low-grade tumors), enhancements of solid components, and calcification. (wikidoc.org)
  • Mucoepidermoid carcinoma represents one of the most common malignant salivary gland tumors.However, the sclerosing morphologic variant is extremely rare with only 23 reported cases in the English-language literature since it was discovered in 1987. (ac.ir)
  • Malignant tumors of the salivary gland are rare, clinically diverse group of neoplasms, among which mucoepidermoid carcinomas (MECs) are reported to be most frequently occurring epithelial carcinomas. (plexusmd.com)
  • Of 298 bronchial adenomas reported from the Mayo Clinic in 1978, 89 percent were classified as carcinoid tumors, 6 percent as adenoid cystic carcinomas, and 4 percent as mucoepidermoid carcinomas. (levelofhealth.com)
  • Mucoepidermoid breast cancer tumors will often be surrounded by a fibrous pseudocapsule. (breast-cancer.ca)
  • But, there is quite often no 'generic' invasive ductal carcinoma component in these tumors. (breast-cancer.ca)
  • Additional, mucoepidermoid breast tumors are frequently estrogen and progesterone receptor negative . (breast-cancer.ca)
  • For example, in mucoepidermoid carcinomas, one of the most common types of malignant salivary gland tumors, a commonly seen genetic translocation [t(11;19)(q21;p13), which involves the CRTC1 and MAML2 genes] has been found to be associated with improved survival, making it a possible prognostic marker. (cancernetwork.com)
  • Mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and adenocarcinoma represent the majority, accounting for more than 75% of these tumors (Table 1). (cancernetwork.com)
  • In general, it is not difficult to distinguish mucoepidermoid carcinoma from other tumors arising from salivary glands by histopathological examination because of its distinct triphasic cellular morphology. (biomedcentral.com)
  • Thymomas and thymic carcinomas are epithelial tumors of the thymus. (healthlinkbc.ca)
  • Invasive thymomas and thymic carcinomas are relatively rare tumors, which together represent about 0.2% to 1.5% of all malignancies. (healthlinkbc.ca)
  • Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. (frontiersin.org)
  • The two major subtypes of PSGT are pulmonary adenoid cystic carcinoma (PACC) and pulmonary mucoepidermoid carcinoma (PMEC). (frontiersin.org)
  • Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. (elsevier.com)
  • Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. (elsevier.com)
  • Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. (elsevier.com)
  • its significance in pulmonary mucoepidermoid carcinoma warrants further study. (elsevier.com)
  • Thirty nine pulmonary mucoepidermoid carcinoma (4 low, 30 intermediate, 5 high grade) contained mucous, epidermoid and intermediate cells and lacked keratinization and in situ carcinoma of the overlying epithelium. (elsevier.com)
  • one developed metastatic pulmonary mucoepidermoid carcinoma. (elsevier.com)
  • In conclusion, features helpful in distinguishing pulmonary mucoepidermoid carcinoma from other lung cancers include its central/endo-or peribronchial location together with the presence of mucous cells, p63 expression, lack of keratinization and MAML2 rearrangement. (elsevier.com)
  • Introduction Pulmonary mucoepidermoid carcinoma is a rare cancer that occurs primarily in younger patients. (paperity.org)
  • The prognostic factors of pulmonary mucoepidermoid carcinoma are largely undetermined, especially in elderly patients. (paperity.org)
  • The aim of this study was to examine the clinical characteristics and prognostic factors influencing survival after surgical resection in patients with pulmonary mucoepidermoid carcinoma and also analyze the clinical manifestations and prognostic factors in elderly patients. (paperity.org)
  • Materials and methods The pathological records of 41 pulmonary mucoepidermoid carcinoma patients (mean age, 61.4 years) who underwent surgical resection at our hospital between January 1991 and July 2015 were retrospectively reviewed. (paperity.org)
  • Conclusions Prognostic factors identified for pulmonary mucoepidermoid carcinoma in this study differ from those of previous studies. (paperity.org)
  • Introduction Pulmonary mucoepidermoid carcinoma (PMEC) can be an uncommon neoplasm from the lung and the primary salivary gland-type lung carcinoma. (lecollege.org)
  • I had a mucoepidermoid carcinoma of the parotid at age 17 in 1978. (cancer.org)
  • Expression of mTOR mRNA and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland and their relationship with prognosis]. (physiciansweekly.com)
  • To investigate the expression of rapamycin target protein (mTOR) mRNA and transferrin receptor 1(Tfr1) mRNA in mucoepidermoid carcinoma of parotid gland and its relationship with prognosis. (physiciansweekly.com)
  • From June 2013 to July 2015 in Tangshan Workers' Hospital, 35 patients with mucoepidermoid carcinoma of parotid gland were selected. (physiciansweekly.com)
  • The relative expression of mTOR and Tfr1 mRNA in mucoepidermoid carcinoma of parotid gland was detected. (physiciansweekly.com)
  • The relationship between mTOR mRNA, Tfr1 mRNA and the clinicopathology and prognosis of mucoepidermoid carcinoma of parotid gland was analyzed using SPSS19.0 software package. (physiciansweekly.com)
  • The relative expression of mTOR mRNA and Tfr1 mRNA in patients with mucoepidermoid carcinoma of parotid gland was significantly increased, which can be used to evaluate the prognosis of patients. (physiciansweekly.com)
  • Question: Dear Sir/Madam, I had low grade mucoepidermoid carcinoma of right parotid 7 years ago with perineural invasion . (healthcaremagic.com)
  • Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ hybridization, and DNA ploidy analysis. (nih.gov)
  • Mucoepidermoid carcinoma of Parapharyngeal Space (PPS) not originating from parotid is a very rare finding. (jcdr.net)
  • Most mucoepidermoid carcinomas occur in the parotid gland and represent the most common primary malignant neoplasia of the salivary glands. (pathwaymedicine.org)
  • CT scan of face showing mucoepidermoid carcinoma of parotid gland. (wikidoc.org)
  • 4. Chan JKC, Saw D. Sclerosing mucoepidermoid tumour of the parotid gland: report of a case. (ac.ir)
  • Sclerosing Mucoepidermoid Carcinoma of the Parotid Gland: A Case Report. (ac.ir)
  • 6. Fadare O, Hileeto D, Gruddin YL, Mariappan MR. Sclerosing mucoepidermoid carcinoma of the parotid gland. (ac.ir)
  • 8. Muller S, Barnes L, Goodurn WJ.J. Sclerosing mucoepidermoid carcinoma of the parotid. (ac.ir)
  • Sclerosing Mucoepidermoid Carcinoma of the Parotid Gland', Iranian Journal of Otorhinolaryngology , 28(4), pp. 281-285. (ac.ir)
  • Patients: From 1940 to 1994, 128 patients were treated at our institution for parotid mucoepidermoid carcinoma. (elsevier.com)
  • With adequate parotidectomy and appropriate neck dissection, patients with mucoepidermoid carcinoma of the parotid gland appear to do well, with few recurrences. (elsevier.com)
  • Expression pattern of PLUNC proteins as an auxiliary tool for the diagnosis of high-grade mucoepidermoid carcinoma of the salivary gland. (semanticscholar.org)
  • The very rare high grade mucoepidermoid carcinoma must be distinguished with care from the much more common adenosquamous bronchogenic carcinoma. (jpatholtm.org)
  • Unfortunately, the prognosis for a high-grade mucoepidermoid carcinoma of the breast is rather poor. (breast-cancer.ca)
  • High-grade mucoepidermoid carcinoma of the breast. (elsevier.com)
  • A primary high-grade mucoepidermoid carcinoma of the breast was evaluated preoperatively by fine needle aspiration (FNA) cytology in a 72-year-old woman. (elsevier.com)
  • Low-Grade and High-Grade Mucoepidermoid Carcinoma of the Lung: CT Findings and Clinical Features of 17 Cases. (flipboard.com)
  • Six patients with mucoepidermoid carcinoma in the mandible were studied with both panoramic radiography and computed tomography. (elsevier.com)
  • Mucoepidermoid carcinomas (MECs) of lung are rare neoplasms originating in bronchial submucosal glands and comprising 0.1-0.2% of primary lung cancers. (mysciencework.com)
  • Berstein L, Gurney JG: Carcinomas and other malignant epithelial neoplasms. (cancer.gov)
  • 3 ] Thymic carcinomas are rare and have been reported to account for only 0.06% of all thymic neoplasms. (healthlinkbc.ca)
  • Pathologists must be aware of recognizing low grade sclerosing mucoepidermoid carcinoma which has metastatic potential and is frequently misdiagnosed as a benign lesion. (ac.ir)
  • To confirm the clinical suspicion of metastatic lung carcinoma, fiberoptic bronchoscopy was performed, but no endobronchial abnormality was found. (levelofhealth.com)
  • We report a case of mucoepidermoid carcinoma of the tongue base mimicking an ectopic thyroid. (hindawi.com)
  • We present a case of mucoepidermoid carcinoma with t(3;12)(q24;p13) and polysomy X by cytogenetic and fluorescence in situ hybridization (FISH) techniques. (nih.gov)
  • A case of mucoepidermoid carcinoma of the bronchus in a 7-year-old boy is reported. (bvsalud.org)
  • The following case report deals with a case of mucoepidermoid carcinoma in a 38-year-old male patient who reported with a chief complaint of swelling in the palatal region for 1 year. (atharvapub.net)
  • A case of mucoepidermoid carcinoma of the bronchus with low grade histologic features exhibited an aggressive biological behavior. (elsevier.com)
  • We present a case of mucoepidermoid carcinoma occurring in an old female patient that was misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by both radiologic and intraoperative histopathological examination, respectively. (biomedcentral.com)
  • Mucoepidermoid carcinoma occurring centrally within the jaws is a rare lesion which exhibits considerable histologic variability. (srce.hr)
  • RNA was extracted from archival materials: histologic paraffin specimens in all cases and cytologic specimens in 10 mucoepidermoid carcinoma cases. (aacrjournals.org)
  • The various prognostic factors that have been reported for mucoepidermoid carcinoma include histologic grade, age, gender, clinical stage, extraglandular extension, mitotic activity, MIB1 expression, and p27 expression ( 10 - 14 ). (aacrjournals.org)
  • Seventeen cases of minor gland mucoepidermoid carcinoma were evaluated histochemically in relation to histologic grade of malignancy and glandular site of origin. (jamanetwork.com)
  • Clinical and Histologic Features of Micropapillary Thyroid Carcinomas: Do They Metastasize? (lww.com)
  • Radiographic findings correlated with histologic findings and prognosis of mucoepidermoid carcinoma in the mandible in this limited series. (elsevier.com)
  • Low-grade histologic features of mucoepidermoid carcinoma are not necessarily then indicative of low-grade biological behavior. (elsevier.com)
  • BACKGROUND: Mucoepidermoid carcinoma (MEC) of the lung, which is relatively rare, has been regarded as having low-grade malignant potential. (minervamedica.it)
  • Primary lung mucoepidermoid carcinoma: analysis of prognostic factors using surveillance, epidemiology and end results program. (semanticscholar.org)
  • Approximately 100 cases of primary mucoepidermoid carcinoma of the lung have been reported since this subtype was first recognized by Smetana et al in 1952. (levelofhealth.com)
  • The following is, to our knowledge, the first roentgenographic and post-mortem description of a patient with mucoepidermoid carcinoma of the lung who presented with intracranial metastases. (levelofhealth.com)
  • Cavitary mucoepidermoid carcinoma of lung with metastases in s. (mysciencework.com)
  • Cavitary mucoepidermoid carcinoma of lung with metastases in skeletal muscles as presenting features: a case report and review of the literature. (mysciencework.com)
  • There have been 8 instances of MEC-like pulmonary carcinoma aged 36-78 years: 2 instances had been situated in the bronchus and 6 instances had been situated in the lung. (lecollege.org)
  • BTZ038 hereditary occasions of salivary gland-type lung carcinomas. (lecollege.org)
  • 71% of oncocytic mucoepidermoid carcinoma s showed a MAML2 rearrangement by fluorescence in situ hybridization. (humpath.com)
  • MAML2 rearrangement can be used as supportive evidence to distinguish oncocytic mucoepidermoid carcinoma from other oncocytic lesions. (humpath.com)
  • Oncocytic Mucoepidermoid Carcinoma: Clinicopathologic Description in a Series of 12 Cases. (humpath.com)
  • We report a rare case of an oncocytic mucoepidermoid carcinoma of the trachea, which presented in a 78-year-old woman with hemoptysis. (houstonmethodist.org)
  • To our knowledge, this is the first oncocytic mucoepidermoid carcinoma of the trachea reported. (houstonmethodist.org)
  • Oncocytic differentiation in mucoepidermoid carcinoma (MEC) is uncommon. (elsevier.com)
  • To the best of our knowledge this is the first case of oncocytic mucoepidermoid carcinoma involving the submandibular salivary gland. (elsevier.com)
  • Materials and Methods: 20 samples with the diagnosis of MEC were selected from the archive of the oromaxillofacial pathology department of Mashhad dental school and Ghaem and Omid hospitals which included five samples of grade I, seven samples of grade II and 8 samples of grade III mucoepidermoid carcinoma. (ac.ir)
  • As a teenager who developed low grade mucoepidermoid carcinoma (MEC) of the salivary glands, how might this diagnosis affect my long-term survival? (nih.gov)
  • In the intraoperative histological examination, a diagnosis of squamous cell carcinoma was made based on predominantly invasive epidermoid cells with abundant keratinization and absence of mucin-producing cell component. (biomedcentral.com)
  • However, postoperative histological diagnosis of the lesion was mucoepidermiod carcinoma of liver by thoroughly microscopical inspection and the presence of mucin-producing cells confirmed by Alcian blue staining. (biomedcentral.com)
  • In particular, when the mucoepidermoid carcinoma occurs in an unusual site, a definite diagnosis might not be obtained without carefully histological examination. (biomedcentral.com)
  • At the time of diagnosis, the majority of patients with thymoma or thymic carcinoma are asymptomatic. (healthlinkbc.ca)
  • Mucoepidermoid carcinoma translocated gene 1-mastermind-like gene family ( MECT1-MAML2 ) gene fusion was identified from a recurring t(11;19)(q21;p13) translocation, which is often the sole cytogenetic alteration in this disease. (aacrjournals.org)
  • The MECT1-MAML2 fusion transcript may be specific to mucoepidermoid carcinoma and associated with a distinct mucoepidermoid carcinoma subset that exhibits favorable clinicopathologic features and an indolent clinical course. (aacrjournals.org)
  • Recently, molecular analysis of this translocation resulted in the identification of a fusion transcript resulting from the binding of exon 1 of a novel gene of unknown function, mucoepidermoid carcinoma translocated gene 1 ( MECT1 ), at 19p13 with exons 2 to 5 of a novel member of the mastermind-like gene family ( MAML2 ) at 11q21 ( 3 - 6 ). (aacrjournals.org)
  • In this retrospective study, we analyzed 71 cases of primary salivary gland mucoepidermoid carcinoma and sought to evaluate the clinicopathologic significance of the MECT1-MAML2 fusion transcript. (aacrjournals.org)
  • An important gene associated with Breast Mucoepidermoid Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways is Cell adhesion_Cell-matrix glycoconjugates . (malacards.org)
  • An important gene associated with Thymus Mucoepidermoid Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2). (malacards.org)
  • Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. (malacards.org)
  • CRTC1-MAML2 fusion is often detected in low- or intermediate-grade salivary mucoepidermoid carcinoma (MEC), and it is associated with a favorable clinical course. (biomedcentral.com)
  • Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid in a 46-year-old woman. (bmj.com)
  • Sclerosing mucoepider- moid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. (ac.ir)
  • 10. Urano M, Masato A, Yoshimune H, Makoto K. Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary glands. (ac.ir)
  • 11. Ide F, Obara K, Enatsu K, Mishima K, Saito I. Sclerosing mucoepidermoid carcinoma of oral cavity. (ac.ir)
  • Sclerosing mucoepidermoid carcinoma of the salivary glands. (ac.ir)
  • A rare case of sclerosing mucoepidermoid carcinoma arising in minor salivary glands with immunohistochemical evaluation. (ac.ir)
  • 17. Tian W, Yakirevich E, Matoso A, Gnepp DR. IgG4(+) plasma cells in sclerosing variant of mucoepidermoid carcinoma. (ac.ir)
  • Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a type of cancer that most commonly affects the thyroid gland, but has been reported in the salivary gland as well. (cdc.gov)
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Sclerosing mucoepidermoid carcinoma with eosinophilia. (cdc.gov)
  • Local recurrence of sclerosing mucoepidermoid carcinoma with eosinophilia in the upper lip: a case report. (cdc.gov)
  • Das S, Kalyani R. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. (cdc.gov)
  • Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. (cdc.gov)
  • Primary sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland is a very rare disease. (ijthyroid.org)
  • PTHrP plays a central role in humoral hypercalcemia, and its expression has been reported to be closely associated with bone metastasis of breast carcinoma. (spandidos-publications.com)
  • Carcinoma ex-pleomorphic adenocarcinoma is an aggressive tumour that starts out as a non-cancerous mixed tumour. (cancer.ca)
  • Mucoepidermoid carcinoma (MEC) is the most common malignancy of the major salivary glands. (nih.gov)
  • The present case has significant implications for the entity of primary MEC of the liver which should be distinguished from adenosquamous carcinoma. (biomedcentral.com)
  • Fine needle aspiration cytology suggested thyroid papillary carcinoma. (ijthyroid.org)
  • Immunohistochemical detection of PTHrP was carried out in 21 cases of mucoepidermoid carcinoma in the head and neck region. (spandidos-publications.com)
  • However, various cases of mucoepidermoid carcinoma with poor prognoses are estimated to have low-grade malignancy upon histological examination. (spandidos-publications.com)
  • Mucoepidermoid carcinoma cell types are classified histologically as low, intermediate, and high-grade types. (oralcancerfoundation.org)
  • Histologically, mucoepidermoid carcinoma is comprised of 3 different cell types: mucinous cells, intermediate cells and epidermoid cells. (spandidos-publications.com)
  • Histologically, mucoepidermoid carcinoma is characterized by squamoid (epidermoid), mucus producing and cells of intermediate type. (biomedcentral.com)
  • Hi, I just found out that I have Mucoepidermoid Carcinoma of the minor salivary glands. (cancer.org)
  • Our results suggested that nuclear MRP1 is highly associated with better prognosis of human mucoepidermoid carcinoma and further study of its function mechanism would provide clues in developing new treatment modalities of MEC. (duhnnae.com)
  • Subjects and Methods: In this study, tissue specimens of 18 pleomorphic denoma (PA) and 9 mucoepidermoid carcinoma (MEC) were examined by immunohistochemistry for p63 expression. (journaldatabase.info)
  • In the present study, the main goal was to determine expression of human tissue kallikreins 4, 8, 10, 11 and 13 in pleomorphic adenomas and mucoepidermoid carcinomas. (iranpath.org)
  • Sixty-six specimens (45 cases of pleomorphic adenomas and 21 cases mucoepidermoid carcinomas) were selected for final analysis by immunohistochemistry. (iranpath.org)
  • However, the high-grade type of mucoepidermoid carcinoma of the breast is very aggressive and frequently produces lymph node and distant metastases . (breast-cancer.ca)
  • Having radiation to your head and neck can raise your risk for mucoepidermoid carcinoma. (webmd.com)
  • The characteristics of mucoepidermoid carcinoma under the microscope are sheets of epidermoid cells with areas of definite squamous differentiation. (breast-cancer.ca)
  • In the low-grade variety of mucoepidermoid breast carcinoma, the squamous cells will quite often show keratinization and glandular cells forming distinct small lumina. (breast-cancer.ca)
  • Among the most common histological subtype is adenoid cystic carcinoma, which often harbors a chromosome translocation resulting in an MYB-NFIB oncogene, with various degrees of Myb surface expression. (frontiersin.org)
  • We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological examinations, respectively. (biomedcentral.com)
  • Mucoepidermoid carcinomas have been reported at distant and atypical sites, including the breast, Eustachian tube of the ear, bronchi of the lungs, and thyroid. (oralcancerfoundation.org)
  • Are RET/PTC Translocations Specific for Papillary Thyroid Carcinoma? (lww.com)
  • We previously reported that PTHrP is highly expressed in oral carcinoma cell lines and that it promotes malignancy of oral cancers ( 8 ). (spandidos-publications.com)
  • Therefore, we evaluated the PTHrP expression in mucoepidermoid carcinoma and herein discuss its role in malignancy. (spandidos-publications.com)
  • Mucoepidermoid carcinoma is a common salivary gland malignancy characterized by genetic heterogeneity as well as cellular diversity of its neoplastic components, which include mucinous cells, epidermoid cells and intermediate cells. (naver.com)
  • The case presented is a 43 year old woman with central mucoepidermoid carcinoma on the left side of the mandible. (scitechnol.com)
  • Mucoepidermoid carcinoma (MEC) occurs at all ages, even in childhood, but it usually presents in the 6th and 7th decades, predominantly in males. (alpfmedical.info)
  • Juvenile mucoepidermoid carcinoma is a rare disease that occurs most often in the minor glands of the hard palate. (bvsalud.org)
  • Mucoepidermoid carcinoma is an uncommon type of breast cancer that resembles mucoepidermoid cancers of the salivary glands . (breast-cancer.ca)
  • Mucoepidermoid carcinomas of the oral cavity have rarely been reported in the pediatric and adolescent age group. (cancer.gov)
  • We present a clinical case of a mucoepidermoid carcinoma in the PPS in a 62-year-old female who presented to a tertiary care hospital with complaints of throat pain and difficulty in swallowing for duration of one month. (jcdr.net)
  • Salivary duct carcinomas may overexpress Her-2 and androgen receptors, with promising clinical outcomes after exposure to targeted therapies approved for other indications. (frontiersin.org)
  • This study aimed to evaluate the long-term survival outcomes and prognostic factors that affect the clinical outcomes of patients who underwent surgery and postoperative radiotherapy for major salivary gland mucoepidermoid carcinoma (MEC). (e-roj.org)
  • Mucoepidermoid carcinoma (MEC) is a malignant epithelial neoplasm characterized by proliferation of epidermoid, mucous, and intermediate cells in various proportions. (ovid.com)
  • Excisional biopsy, Extravasated mucous cyst, Mucoepidermoid carcinoma. (atharvapub.net)
  • Adenoid cystic carcinomas can be made up of 3 types of cells. (cancer.ca)
  • Adenoid cystic carcinomas are divided into types based on the cells they have in them. (cancer.ca)
  • Cribriform adenoid cystic carcinomas have cancer cells surrounded by normal cells. (cancer.ca)
  • Solid adenoid cystic carcinomas have cells that look like solid sheets when examined under a microscope. (cancer.ca)
  • Tubular adenoid cystic carcinomas are made up of cells shaped like tubes. (cancer.ca)
  • Mucoepidermoid carcinoma is a type of cancer of the salivary glands . (nih.gov)
  • Salivary gland cancer is diagnosed in 2-3 individuals per 100,000 people each year, and 30-35% of these are mucoepidermoid carcinomas. (nih.gov)
  • Adenoid cystic carcinoma is the 2nd most common type of salivary gland cancer. (cancer.ca)
  • In many cases, the cancer has spread to lymph nodes when salivary duct carcinoma is diagnosed. (cancer.ca)
  • Indeed, there are generally three distinct elements, in varying degrees, that compose mucoepidermoid breast cancer. (breast-cancer.ca)
  • Possibly, intraductal carcinoma foci and invasive cancer nests make up this capsule. (breast-cancer.ca)
  • Bronchial mucoepidermoid carcinoma after allogeneic bone marrow transplantation. (bmj.com)
  • Carcinoid and mucoepidermoid bronchial tumours in children. (cancer.gov)
  • Acinic cell carcinoma is usually slow growing with a fairly good prognosis. (cancer.ca)
  • Prognostic factors in mucoepidermoid carcinoma of the salivary glands. (nih.gov)
  • As the name suggests, mucoepidermoid carcinomas consist of a mixture of cells ranging from epithelial squamous cells to mucus-secreting cells along with forms intermediate between these two extremes intermediate. (pathwaymedicine.org)
  • 12 A breast metaplastic carcinoma that is characterized by the presence of four cell types (basaloid, intermediate, epidermoid, and mucinous) in varying proportions. (malacards.org)
  • Salivary duct carcinoma is a very aggressive type of tumour that can advance quickly. (cancer.ca)