Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and an epidermal cell.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
A species of POLYOMAVIRUS suspected to be the cause of most cases of MERKEL CELL CARCINOMA, a rare but highly lethal form of skin cancer.
Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Tumors or cancer of the SKIN.
A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
MUCOUS MEMBRANE extending from floor of mouth to the under-surface of the tongue.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Tumors or cancer of the LIVER.
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A cell line derived from cultured tumor cells.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A type II keratin found associated with KERATIN-18 in simple, or predominately single layered, internal epithelia.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Tumors or cancer of the LUNG.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Tumors or cancer of the LIP.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Tumors of cancer of the EYELIDS.
The part of the face that is below the eye and to the side of the nose and mouth.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the NASOPHARYNX.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The specificity of a virus for infecting a particular type of cell or tissue.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Merkel cell carcinoma and melanoma: etiological similarities and differences. (1/218)

Merkel cell carcinoma (MCC) of the skin and cutaneous malignant melanoma can now be compared epidemiologically through the use of population-based data not previously available for MCC. The results may provide new clues to etiology. In this study, United States data covered by the Surveillance, Epidemiology, and End Results (SEER) Program were from nine areas of the United States (approximately 10% of the population). In 1986-1994, 425 cases of MCC were registered. The annual age-adjusted incidence per 100,000 of MCC was 0.23 for whites and 0.01 for blacks; among whites, the ratio of melanoma to MCC was approximately 65 to 1. Only 5% of MCC occurred before age 50, unlike the lifelong risk of nodular and superficial spreading melanoma. Regional incidence rates of both cancers increased similarly with increasing sun exposure as measured by the UVB solar index. The most sun-exposed anatomical site, the face, was the location of 36% of MCC but only 14% of melanoma. Both cancers increased in frequency and aggressiveness after immunosuppression and organ transplantation (36 cases from the Cincinnati Transplant Tumor registry and 12 from published case reports) and after B-cell neoplasia (5 cases in this study; 13 from case series in the literature). The SEER data contained reports of six patients with both types of cancer; 5 melanomas before the diagnosis of MCC and 1 after diagnosis. MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face.  (+info)

Mutation analysis of P73 and TP53 in Merkel cell carcinoma. (2/218)

The p73 gene has been mapped to 1p36.33, a region which is frequently deleted in a wide variety of neoplasms including tumours of neuroectodermal origin. The p73 protein shows structural and functional homology to p53. For these reasons, p73 was considered as a positional and functional candidate tumour suppressor gene. Thus far, mutation analysis has provided no evidence for involvement of p73 in oligodendrogliomas, lung carcinoma, oesophageal carcinoma, prostatic carcinoma and hepatocellular carcinoma. In neuroblastoma, two mutations have been observed in a series of 140 tumours. In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines and ten MCC tumours to test potential tumour suppressor function for this gene in MCC. In view of the possible complementary functions of p73 and TP53 we also examined the status of the TP53 gene. Sequence analysis of the entire coding region of the p73 gene revealed previously reported polymorphisms in four MCCs. In one MCC tumour, a mis-sense mutation located in the NH2-terminal transactivation region of the p73 gene was found. These results show that p73, analogous to neuroblastoma, is infrequently mutated in MCC. This is also the first report in which the role of TP53 in MCC has been investigated by sequencing the entire coding region of TP53. TP53 mis-sense mutations and one non-sense mutation were detected in three of 15 examined MCCs, suggesting that TP53 mutations may play a role in the pathogenesis or progression of a subset of MCCs. Moreover, typical UVB induced C to T mutations were found in one MCC cell line thus providing further evidence for sun-exposure in the aetiology of this rare skin cancer.  (+info)

Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. (3/218)

Merkel cell carcinoma was first described in 1972 by Toker and is an aggressive neuroendocrine skin tumor with a high metastatic potential. Merkel cell carcinoma is thought to derive from the neuroendocrine (Merkel) cells of the skin, although in contrast to fetal and especially adult Merkel cells, Merkel cell carcinomas express high levels of the Bcl-2 oncoprotein. Bcl-2 is capable of blocking programmed cell death and has been shown to play an important role in normal cell turnover, tumor biology, and chemoresistance. High Bcl-2 expression leading to prolonged survival of cells may therefore be of importance in the biological and clinical characteristics of Merkel cell carcinoma. In a SCID mouse xenotransplantation model for human Merkel cell carcinoma, we investigated the influence of the bcl-2 antisense oligonucleotide G3139 (Genta) on tumor growth in comparison with control oligonucleotides or cisplatin. Bcl-2 antisense treatment, targeting the first six codons of the bcl-2 mRNA, resulted in either a dramatic reduction of tumor growth or complete remission, whereas reverse sequence and two-base mismatch control oligonucleotides or cisplatin had no significant antitumor effects compared with saline-treated controls. Apoptosis was enhanced 2.4-fold in the bcl-2 antisense treated tumors compared with the saline-treated group, and no other treatment showed a comparable increase in apoptosis. Our findings suggest that bcl-2 antisense treatment may be a novel approach to improve treatment outcome of human Merkel cell carcinoma.  (+info)

Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. (4/218)

PURPOSE: To study the use of chemotherapy for Merkel cell carcinoma (MCC) of the skin. PATIENTS AND METHODS: Twenty-five cases of MCC were treated at the London Regional Cancer Center between 1987 and 1997. Thirteen cases treated with chemotherapy were reviewed with 191 cases from the literature. RESULTS: At presentation, 24 patients had localized skin lesions (stage I) and one had locoregional involvement (stage II). Among the nine cases with recurrent nodal disease, six had chemotherapy as a component of salvage treatment. They were all free of disease at a median of 19 months (range, 12 to 37 months). In contrast, two patients who had salvage radiotherapy alone died of disease. Overall survival (OS) and disease-free survival (DFS) were 59% and 43%, respectively, at two years. Median OS and DFS were 29 months (range, 1 to 133 months) and 9 months (range, 1 to 133 months), respectively. Nodal disease developed in 12 (50%) of 24 patients with stage I disease, and distant metastases developed in six (25%) of 24. Including those from the literature, there were 204 cases treated with chemotherapy. Cyclophosphamide/doxorubicin (or epirubicin)/vincristine combination +/- prednisone was the most commonly used chemotherapy regimen (47 cases), with an overall response rate of 75.7% (35.1% complete, 35. 1% partial, and 5.4% minor responses). Etoposide/cisplatin (or carboplatin) was the next most commonly used regimen (27 cases), with an overall response rate of 60% (36% complete and 24% partial responses). The difference in response rate was not statistically significant (P =.19). Among the 204 cases, there were seven (3.4%) toxic deaths. CONCLUSION: Chemoradiation for locally recurrent or advanced disease may be an option for patients with a good performance status.  (+info)

Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies. (5/218)

This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in the subcutaneous interstitial space and in tumour tissue (melanoma, malignant fibrous histiocytoma, Merkel cell tumour and osteosarcoma) in patients undergoing regional chemotherapy by Isolated Limb Infusion (ILI). 19 patients undergoing ILI for treatment of various limb malignancies were monitored for intra-operative melphalan concentrations in plasma and, using microdialysis, in subcutaneous and tumour tissues. Peak and mean concentrations of melphalan were significantly higher in plasma than in subcutaneous or tumour microdialysate. There was no significant difference between drug peak and mean concentrations in interstitial and tumour tissue, indicating that there was no preferential uptake of melphalan into the tumours. The time course of melphalan in the microdialysate could be described by a pharmacokinetic model which assumed melphalan distributed from the plasma into the interstitial space. The model also accounted for the vascular dispersion of melphalan in the limb. Tumour response in the whole group to treatment was partial response: 53.8% (n = 7); complete response: 33.3% (n = 5); no response: 6.7% (n = 1). There was a significant association between tumour response and melphalan concentrations measured over time in subcutaneous microdialysate (P< 0.01). No significant relationship existed between the severity of toxic reactions in the limb or peak plasma creatine phosphokinase levels and peak melphalan microdialysate or plasma concentrations. It is concluded that microdialysis is a technique well suited for measuring concentrations of cytotoxic drug during ILI. The possibility of predicting actual concentrations of cytotoxic drug in the limb during ILI using our model opens an opportunity for improved drug dose calculation. The combination of predicting tissue concentrations and monitoring in microdialysate of subcutaneous tissue could help optimise ILI with regard to post-operative limb morbidity and tumour response.  (+info)

Indium-111 octreotide scintigraphy of Merkel cell carcinomas and their metastases. (6/218)

BACKGROUND: Somatostatin receptor scintigraphy (SRS) may be of interest for staging Merkel Cell Carcinoma (MCC). This study was undertaken to evaluate the sensitivity and specificity of SRS and to determine its role compared to conventional investigations. PATIENTS AND METHODS: From 1993 to December 2000, 20 patients (10 females and 10 males, aged from 38 to 88, mean 66 years) were included prospectively. At the time of SRS: 12 patients had been diagnosed as having stage I disease, 6 stage II and 4 stage III. Two patients had two SRS studies during the course of their disease. SRS was performed with Indium-111 pentetreotide (Octreoscan), a radiolabelled somatostatin analogue. Patients were treated according to the clinical stage. A regular follow-up was scheduled every three months. RESULTS: SRS depicted stage I and II MCC tumour sites with an overall sensitivity of 78% (95% confidence interval (CI): 40%-97%) and a specificity of 96% (81%-100%). The histopathological diagnosis was used as the gold standard. Sites visualised by SRS were compared to those detected with conventional modalities and to follow-up data for all stages: SRS visualised four out of five primary tumour sites, six out of eight lymph node sites, no skin metastases (14 sites in 2 patients), two out of three thoracic metastases and zero out of two hepatic metastases. SRS did not influence treatment decision-making in any of the cases. CONCLUSIONS: Although SRS seems highly specific in MCC and could be of help in difficult cases, it cannot be recommended for routine evaluation.  (+info)

Merkel cell carcinoma: a rare cause of hypervascular nasal tumor. (7/218)

Cutaneous neuroendocrine carcinoma, first described in 1972, is an aggressive disease usually occurring in sun-exposed skin. Other sites have been described, however; such tumors occasionally occur within the nasal fossa. A high rate of metastasis (>30%) explains the poor prognosis. Descriptions of the imaging features of these tumors, mainly located in cutaneous region, are rare. We therefore present the imaging features of two cases of Merkel cell carcinoma involving the sinonasal region, suggestive of a hypervascular tumor.  (+info)

Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. (8/218)

AIM: To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). METHODS: Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. RESULTS: Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. CONCLUSIONS: The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.  (+info)

Merkel cell carcinoma is a rare and aggressive skin malignancy that arises from primary neural cells and has a tendency for local recurrence and regional lymph node metastases. There are only a few cases in the literature reporting metastases of Merkel cell carcinoma to the gastrointestinal tract. We present a 70 year old Caucasian female with distant history of Merkel cell carcinoma who presented with iron-deficiency anemia. Colonoscopy performed later for the evaluation of anemia revealed 1 cm polyp in ascending colon which turned out to be the recurrence of Merkel cell carcinoma. Metastatic Merkel cell carcinoma to the gastrointestinal tract or any other organ should be considered in patients with a history of Merkel cell carcinoma.
1. Lemos B, Nghiem P: Merkel cell carcinoma: more deaths but still no pathway to blame. J Investig Dermatol 2007; 127: 2100-2103. 2. Lemos BD, Storer BR, Iyer JG et al.: Pathologic nodal evaluation improves prognostic accuracy in merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63: 751-761. 3. Toker C: Trabecular carcinoma of the skin. Arch Dermatol 1972; 105: 107-110. 4. Agelli M, Clegg LX: Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 2003; 49: 832-841. 5. Miller RW, Rabkin CS: Merkel cell carcinoma and melanoma: etiology similarities and differences. Cancer Epidemiol Biomarkers Prev 1999; 8: 485. 6. Feng H, Shuda M, Chang Y et al.: Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008; 319: 1096-1100. 7. Shuda M, Feng H, Kwun HJ et al.: T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA 2008; ...
So these are the characteristics of the 88 patients treated. You can see 25% of the patients were under 65, the vast majority of patients were over the age of 65, consistent with the clinical course of Merkel cell carcinoma. 74% of the patients were men, most had good ECOG performance status. Not surprisingly, 76% of the patients presented with a primary cutaneous Merkel cell carcinoma but some patients their initial presentation was in the lymph node or other sites. Although 59% of the patients had one prior therapy its important to note that 35% of this population had actually failed two or more lines of prior therapy so this is a fairly advanced group. 53% of the patients had evidence of visceral metastases at the study entry and 21% had only lymph node disease at the time they entered.. We also looked at the tumour burden to see if that might be an independent predictor of response, so that data is shown there. We basically measured the sum of the longest diameters of all the index lesions ...
Merkel cell carcinoma is an aggressive type of skin cancer. Merkel cell carcinoma generally appears in sun-damaged regions of skin of the head, neck, mouth, upper and lower limbs, truck and genital lining. It is more common in elderly males. Merkel cell carcinoma can re-occur after treatment. Want to know about Merkel cell carcinoma? Wondering how it can be treated? Read the following article to know all about the treatment for Merkel cell carcinoma, its causes, symptoms, and complications.
Avelumab showed early positive survival data and lasting responses for patients with pretreated advanced or metastatic Merkel cell carcinoma, according to findings from the phase II JAVELIN Merkel 200 trial presented at the 2016 ASCO Annual Meeting.
Primary: To compare the efficacy, as measured by objective response rate (ORR), provided by nivolumab plus ipilimumab with or without SBRT in subjects with metastatic Merkel cell carcinoma. Secondary: To compare the progression free survival (PFS) of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To compare the overall survival (OS) of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To evaluate the local control of irradiated tumor provided by SBRT in combination with nivolumab and ipilimumab. To assess the overall safety and tolerability of of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To evaluate whether PD-L1 expression is a predictive biomarker for ORR. To evaluate the Health Related Quality of Life (HRQoL) as assessed by European Organisation for Research and Treatment of Cancer ...
On September 24, 2017, Posted by Birgit Rogell , In Press Releases, With Kommentare deaktiviert für Merck: European Commission Approves Bavencio (avelumab) for Metastatic Merkel Cell Carcinoma ...
TY - JOUR. T1 - Merkel cell carcinoma. T2 - Diagnosis, management, and outcomes. AU - Senchenkov, Alex. AU - Moran, Steven Lawrence. PY - 2013/5. Y1 - 2013/5. N2 - Merkel cell carcinoma is a rare, aggressive cutaneous malignancy with high rates of recurrence, metastases, and mortality. Its nonspecific clinical presentation often delays the diagnosis, and its treatment is still controversial because of the infrequent nature of the tumor. The authors provide an overview of the current literature on epidemiology, cause, pathogenesis, staging, management, and outcomes of this disease. Effective diagnostic and treatment modalities such as wide local excision of the primary tumor, importance of sentinel node biopsy for staging, evidence for the use of adjuvant radiation therapy, and emphasis on a multidisciplinary treatment approach of Merkel cell carcinoma as it pertains to surgical practice are reviewed.. AB - Merkel cell carcinoma is a rare, aggressive cutaneous malignancy with high rates of ...
Merkel cell carcinoma (MCC) is a rare form of skin cancer, often described as the most aggressive cutaneous malignancy. Its high propensity for dermal-lymphatic invasion, local recurrence, and rapid lymphatic and distant metastasis poses a significant treatment challenge to clinicians. Combining its highly aggressive nature with its low incidence, merkel cell carcinoma is a particularly difficult cancer to study. Two major staging criteria exist for Merkel cell carcinoma. The purpose of this study is to validate and compare the Memorial Sloan Kettering Cancer Center (MSKCC) staging criteria with the American Joint Committee on Cancer (AJCC) Tumor, Node, Metastasis (TNM) staging criteria for Merkel cell carcinoma (MCC) utilizing the Surveillance, Epidemiology, and End Results (SEER) database. The role of radiation therapy (RT) is also evaluated. 1556 cases of MCC from the SEER database (1988-2002) were identified and evaluated. Tumor size, lymph node status, and metastases were staged according to the
TY - JOUR. T1 - Expression profiles associated with aggressive behavior in Merkel cell carcinoma. AU - Fernández-Figueras, María Teresa. AU - Puig, Lluís. AU - Musulén, Eva. AU - Gilaberte, Montserrat. AU - Lerma, Enrique. AU - Serrano, Sergio. AU - Ferrándiz, Carlos. AU - Ariza, Aurelio. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm. In spite of its similarities to small cell carcinomas from other locations, Merkel cell carcinoma shows many peculiarities probably related to its epidermal origin and the etiologic role of UV radiation. We have immunohistochemically investigated 43 markers on a tissue microarray in which 31 surgically resected Merkel cell carcinomas were represented. Of these, 15 patients remained free of disease after removal, whereas 16 developed metastases. Immunoreactivity was scored according to staining intensity and the percentage of positive cells. We found ...
Full Title A Phase II Randomized Parallel Two-Arm Clinical Trial Assessing Comprehensive Ablative Radiation Therapy with or without Avelumab in Unresectable and Metastatic Merkel Cell Carcinoma (CARTA) Purpose The purpose of this study is to assess the safety and effectiveness of comprehensive ablative radiation therapy (CART) with or without the immunotherapy drug avelumab in patients with inoperable or metastatic Merkel cell carcinoma (MCC) that has continued to grow despite prior immunotherapy.
Merkel cell carcinoma is a malignant skin tumor with a poor prognosis that primarily affects photoexposed areas of elderly patients. Tumor size is a very strong prognostic factor, with much better outcomes associated with small lesions, measuring less than 1cm. However, such lesions are rarely seen in the clinic in view of the rapid growth of this tumor. We report 2 cases of incipient Merkel cell carcinoma. Both cases of incipient Merkel cell carcinoma measured approximately 5mm in diameter. One tumor was confined to the epidermis and papillary dermis on the nose of a 79-year-old man and the other was located in the deep dermis, almost in the hypodermis, on the buttock of an 82-year-old woman. In both cases, the lesions had appeared weeks earlier. The first tumor seemed to originate in the dermoepidermal junction whereas the second originated almost in the hypodermis. Although the lesions were at a similar disease stage and had a similar size, their different locations within the dermis ...
INTRODUCTION: Merkel cell carcinoma is a rare cutaneous, aggressive tumor. Although it shares many neuroendocrine features with small cell lung carcinoma, it has only occasionally been reported with paraneoplastic neurological syndromes. METHODS: A healthy 67-year-old man developed acute ataxia, vertigo, and nausea. Subsequently he also developed dysarthria, diplopia, xerostomia, fatigability and progressive anorexia. He underwent a full diagnostic workup and was found to have a high titer of voltage-gated calcium channel antibodies in serum and cerebrospinal fluid, neurophysiological findings compatible with Lambert-Eaton myasthenia and neurological signs compatible with cerebellar degeneration. RESULTS: A positron emission tomography study revealed a hypermetabolic lesion in the axilla, subsequently biopsied and consistent with Merkel cell carcinoma. CONCLUSIONS: In most previous reports, neurological symptoms preceded the Merkel cell carcinoma diagnosis, and the primary localization was in lymph
Merkel cell carcinoma commonly present on the extremities and the head. Merkel cell carcinoma is a form of subcutaneous to cutaneous papule or nodule. Merkel cell carcinoma is a red, violet,pink or reddish brown dome shaped lesion.
Find the best merkel cell carcinoma doctors in Navi Mumbai. Get guidance from medical experts to select merkel cell carcinoma specialist in Navi Mumbai from trusted hospitals - credihealth.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has been discovered between MCC and either integration of the Merkel cell polyomavirus, which likely drives tumorigenesis, or somatic mutations owing to ultraviolet-induced DNA damage. Both virus-positive and virus-negative MCCs are immunogenic, and inhibition of the programmed cell death protein 1 (PD-1)-programmed cell death 1 ligand 1 (PD-L1) immune checkpoint has proved to be highly effective in treating patients with metastatic MCC; however, not all patients have a durable response to immunotherapy. Despite these rapid advances in the understanding and management of patients with MCC, many basic, translational and clinical research questions remain unanswered. In March 2018, an International Workshop on Merkel Cell Carcinoma Research was held at the US National Cancer Institute, at which academic, government and industry experts met to ...
Given the lack of effective treatment options for patients with metastatic Merkel cell carcinoma whose cancer has recurred after chemotherapy, we are excited to see such a high objective response rate. It is also noteworthy that nearly all of the patients whose cancer initially responded to avelumab exhibited durable responses, with most ongoing for more than a year, continued Kaufman, who is also professor of surgery and medicine at the Rutgers Robert Wood Johnson Medical School. Based on data from this clinical trial, avelumab became the first ever treatment approved by the U.S. Food and Drug Administration for treating patients with this devastating disease.. Kaufman explained that avelumab targets the PD-L1 protein and that the rationale for treating patients with Merkel cell carcinoma with the immunotherapeutic came from studies showing that PD-L1 is found on tumor samples from nearly all patients with this form of cancer.. Kaufman and colleagues enrolled 88 patients with metastatic ...
Merkel cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by a virus (Merkel cell polyomavirus)
Evidence-based recommendations on avelumab (Bavencio) for treating metastatic (secondary) Merkel cell carcinoma (skin cancer) in adults
TY - JOUR. T1 - Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC. AU - Becker, Juergen C.. AU - Stang, Andreas. AU - zur Hausen, Axel. AU - Fischer, Nicole. AU - DeCaprio, James A.. AU - Tothill, Richard W.. AU - Lyngaa, Rikke. AU - Hansen, Ulla Kring. AU - Ritter, Cathrin. AU - Nghiem, Paul. AU - Bichakjian, Christopher K.. AU - Ugurel, Selma. AU - Schrama, David. PY - 2018. Y1 - 2018. N2 - Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations affect comparable signaling pathways such as RB restriction of cell cycle progression or p53 inactivation. Despite its low incidence, MCC recently received much attention based on its exquisite immunogenicity and the resulting major success of immune modulating ...
So you might say this would be a great test, but we dont use it in our patients. Why not? Because it makes no difference therapeutically to the one in five patients who has this favorable CD8 profile. Such patients need to receive the same treatment as other patients, regardless of CD8 infiltration status. Disease can recur in such patients, but if it does, we can cure it. Because the CD8 profile really doesnt change our management, we dont routinely do this test.. Optimal Management. Whats the optimal approach, then, for managing the newly diagnosed Merkel cell carcinoma patient? In most cases of Merkel cell carcinoma (about 80%), Merkel cell polyomavirus is clonally integrated in the tumor cells, and viral oncoproteins drive oncogenesis. There is increasing evidence that these patients do somewhat better than polyomavirus-negative patients. What this means clinically is that the 20% of patients who are virus-negative might need more careful monitoring for recurrence.. Several early ...
Business Wire IndiaMerck and Pfizer today announced that the US Food and Drug Administration (FDA) has granted avelumab*, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, Fast Track designation for the treatment of metastatic Merkel cell carcinoma (MCC), a rare and aggressive type of skin cancer
Merkel cell carcinoma (MCC) is an extremely aggressive epidermis cancer with a growing incidence. This acquiring as well as our observation the fact that PI3K/AKT pathway is certainly activated in nearly all individual MCCs recognizes PI3K/AKT being a potential brand-new therapeutic focus on for MCC sufferers. Launch Merkel cell carcinoma (MCC) is certainly a very intense malignant epidermis tumor. The condition affects older patients. It really is localized in the chronically UV-exposed epidermis preferentially. The relationship between UV light and MCC is most likely because of the immunosuppressive as opposed to the mutagenic aftereffect of UV irradiation. In sufferers with immunosuppression, MCC might occur in a younger age group significantly. The pathogenesis of MCC is really as however not really grasped [1] totally, but the latest demonstration the fact that Merkel cell polyoma pathogen (MCV) DNA is generally within MCC suggests a viral R935788 induced carcinogenesis [2], [3]. Regardless ...
Treatment of 26 patients with advanced previously untreated Merkel cell carcinoma with Keytruda® (pembrolizumab) every three weeks resulted in an overall response rate of 56% suggesting this novel therapy could represent a new treatment option for these hard to treat cancers. Merkel cell carcinoma is a rare aggressive skin cancer with limited treatment options for […]. ...
We have recently discovered a new human polyomavirus monoclonally-integrated into human Merkel cell carcinomas (MCC) that we call Merkel cell polyomavirus (MCPy...
Dr. Xiaohui Bi joins the lab to work on molecular and biological studies of Merkel cell carcinoma. She will use high resolution array-comparative genomic hybridization (CGH) to discover chromosomal copy number alterations (CNAs) that may indicate tumor suppressors (loss of region) and oncogenes (gain of region) in collaboration with Dr. Lynda Chin at the Dana-Farber Cancer Institute. She will also use large scale lentiviral siRNA-based screening in Merkel cell carcinoma cell lines to search for kinases/signaling pathways that are essential for this cell type to grow. siRNA-based screening will be a collaboration with Dr. William Hahn at the Dana-Farber Cancer Institute. Dr. Bi brings a high level of experience in cancer biology and cell cycle biology with her from her postdoctoral fellowship with Dr. Cyrus Vaziri at Boston Medical Center.. ...
Sentinel lymph node biopsy (SLNB) is commonly recommended for patients with primary Merkel cell carcinoma (MCC). However, it is critically discussed whether survival rates improve by SLNB in MCC patients in general or in subgroups of higher risk (e.g. with primary tumor size ,1 cm). The present study correlates clinical data, histology and lymph node status with follow-up and survival data to see if subgroups can be identified for modification of the current recommendations. The medical records of 47 patients with histologically confirmed MCC treated between 1995 and 2010 at a German dermatosurgery department were reviewed. Nineteen patients with excision of the primary tumor and SLNB were compared to 28 patients with excision of the primary tumor but without SLNB. End-points of this study were disease-free survival (DFS) and overall survival (OS). In addition, clinical course was correlated with tumor size and size of safety margin. The group of patients who received SLNB showed a significant ...
Clinical trial for sclc | small cell carcinoma | Small Cell Lung Cancer | Neuroendocrine carcinoma | small cell carcinoma of the lung | Merkel cell carcinoma | Neuroendocrine Carcinoma , Safety and Efficacy of XmAb18087 Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer
Many unanswered questions remain about what constitutes appropriate guidelines for treatment of Merkel cell carcinoma (MCC). In this review, we address current uncertainty surrounding optimal management of Merkel cell carcinoma. These areas of uncertainty include early recognition features; clinical and histopathologic prognostic factors; optimum margins of excision of the primary tumor; indications for and value of surgical staging of the clinically negative regional nodes; optimum management of the patient with pathologically positive regional nodes; and indications for and value of radiation to the primary and regional nodes. Through identifying and elaborating on these areas of uncertainty, the authors hope to foster additional research and ultimately improve the evidence base for future iterations of the NCCN Clinical Practice Guidelines in Oncology in this rare but increasingly encountered cutaneous malignancy. The intent, however, is not to exhaustively identify all areas of controversy, ...
At Moffitt Cancer Center, our oncologists can expertly diagnose any patient who presents with the signs of Merkel cell carcinoma, then stage the cancer following a diagnosis, as we have extensive experience treating even the rarest forms of skin cancer. Appointments are available with or without a physicians referral.. Our oncologists can provide additional information about the Merkel cell carcinoma staging process and the treatment options available for metastatic and non-metastatic skin cancers. To schedule a consultation, call 1-888-663-3488 or submit a new patient registration form online.. ...
Merkel cell carcinoma is a rare and aggressive malignancy of the skin. Approximately 2000 cases of Merkel cell carcinoma have been reported since its first publ
What is Merkel Cell Carcinoma? Get the facts about Merkel Cell Carcinoma symptoms, testing, treatment and care options from trusted sources.
What is Merkel Cell Carcinoma? Get the facts about Merkel Cell Carcinoma symptoms, testing, treatment and care options from trusted sources.
NEW YORK, June 29, 2017 /PRNewswire/ -- Merkel Cell Carcinoma - Pipeline Review, H1 2017. Merkel Cell Carcinoma - Pipeline Review, H1 2017.
Merkel cell carcinoma (also known as a Cutaneous apudoma, Primary neuroendocrine carcinoma of the skin, Primary small cell carcinoma of the skin, and Trabecular carcinoma of the skin is a rare and highly aggressive cancer in which malignant cancer cells develop on or just beneath the skin and in hair follicles.. • The majority of Merkel cell carcinomas appear to be caused in part by a newly discovered virus, Merkel cell polyomavirus or MCV. Direct evidence for this comes from studies showing that inhibition of MCV proteins causes MCV-infected Merkel carcinoma cells to die but has no effect on tumor cells from Merkel cell carcinomas that are not infected with the virus. • This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Once it has metastasized to the lymph nodes, the 5-year survival rate for a patient is about 50 percent. A patient with a small tumor (less than 2 cm) that has not metastasized to the lymph nodes may have a 5-year survival rate of more than 80 ...
The FDA has granted an accelerated approval to pembrolizumab for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma.
Cabozantinib (XL184) is an inhibitor of multiple receptor tyrosine kinases and was approved by the U.S. Food and Drug Administration (FDA) on 29 November 2012 for the treatment of patients with progressive, metastatic medullary thyroid cancer. It is commercially available as COMETRIQ™ in the United States.. During the Pre Treatment Period, participants are consented and qualified (screened) for the study. Treatment will be administered on an outpatient basis.. Each treatment cycle lasts 28 days, during which time the participant will be taking the study drug, cabozantinib, once daily. The participant will be given a study drug-dosing diary for each treatment cycle. The diary will also include special instructions for taking the study drug.. - Participants will be followed for 8 weeks after removal from study or until death, whichever occurs first. Participants removed from study for unacceptable adverse events will be followed until resolution or stabilization of the adverse event. ...
Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations af …
Merkel cell carcinoma (MCC) is one of the most aggressive cancers of the skin. RASSFs are a family of tumor suppressors that are frequently inactivated by promoter hypermethylation in various cancers. We studied CpG island promoter hypermethylation in MCC of RASSF2, RASSF5A, RASSF5C and RASSF10 by combined bisulfite restriction analysis (COBRA) in MCC samples and control tissue. We found RASSF2 to be methylated in three out of 43 (7%), RASSF5A in 17 out of 39 (44%, but also 43% in normal tissue), RASSF5C in two out of 26 (8%) and RASSF10 in 19 out of 84 (23%) of the cancer samples. No correlation between the methylation status of the analyzed RASSFs or between RASSF methylation and MCC characteristics (primary versus metastatic, Merkel cell polyoma virus infection, age, sex) was found. Our results show that RASSF2, RASSF5C and RASSF10 are aberrantly hypermethylated in MCC to a varying degree and this might contribute to Merkel cell carcinogenesis.
Merkel cell carcinoma (MCC) was originally described by Toker in 1972 as trabecular carcinoma of the skin.[1] Other names include Toker tumor, primary small cell carcinoma of the skin, primary cutaneous neuroendocrine tumor, and malignant trichodiscoma.[2] MCC is an aggressive neuroendocrine carcinoma arising in the...
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. To diagnose nodal MCC with an unknown primary disease is challenging, and it has to be separated from other nodal metastatic neoplasms. We report a unique case of nodal MCC in head and neck lesions with an unknown primary. A 70-year-old woman was admitted to our department with a right submandibular mass. Fine needle aspiration biopsy was performed and indicated malignancy. F-18-fluorodeoxyglucose positron emission tomography (PET) demonstrated abnormal accumulation in the right submandibular lymph node, right palatine tonsil, and right thyroid gland. For diagnostics and treatment, bilateral selective neck lymph node dissection, right tonsillectomy, and right thyroidectomy were performed. Histopathological examination revealed that most parts of the submandibular lymph node were occupied by diffuse sheets of tumor cells. Contrary to our expectation, malignant cells were not detected in the right palatine tonsil and ...
Background: There are limited data on the travel burden for cancer patients with rare tumor types, such as Merkel cell carcinoma (MCC).. Objective: The objective of this study was to understand the travel burden of MCC patients.. Methods: This study used data from an MCC registry at the Seattle Cancer Care Alliance (SCCA). All MCC patients enrolled at SCCA with a valid 3-digit ZIP code were included. Patients were followed up from January 1, 2012 until their last follow-up, death, or end of data (January 1, 2017). Travel burden was measured by one-way travel distance to SCCA from each patients 3-digit ZIP code. Patient demographics, tumor characteristics, and follow-up visit were evaluated and stratified by one-way driving distance of ≤300 and ,300 miles.. Results: A total of 391 MCC patients were included (68% men, mean age = 67 years [±SD = ±11 years], 67% residing in the West, and 70% white). At diagnosis, 53% of the patients had Stage III or IV MCC. Mean one-way distance traveled by ...
Merkel cell carcinoma, also known as primary cutaneous neuroendocrine carcinoma,1 was characterized in 1972.2 It is a rare but challenging neuroendocrine cancer of the skin that may sometimes be misdiagnosed as basal cell carcinoma.3 The differential diagnosis may include lymphoma, small cell melanoma, metastatic small cell lung cancer to the skin, and other cutaneous small round cell neoplasms.1 Confirming a diagnosis, therefore, requires histopathologic and immunohistochemical studies. Unfortunately, this malignancy is aggressive, frequently metastatic, and the prognosis is generally poor. More than one third of patients (33% to 46%) die of their disease.4,5. In many cases, Merkel cell polyomavirus is a contributing factor to the development of Merkel cell carcinoma6; somatic mutations induced by ultraviolet light exposure and subsequent DNA damage likely also contribute to the development of the disease.7 There is a higher incidence of Merkel cell carcinoma among immunosuppressed individuals, ...
An NCI Cancer Currents blog post about results from a phase II clinical trial showing durable tumor responses to the immunotherapy drug avelumab in patients with metastatic Merkel cell carcinoma.
The ICD-10 Code C7B.1 is the code used for Secondary Merkel cell carcinoma .An alternative description for this code is Secondary Merkel cell ...
Merkel cell carcinoma is an aggressive neuroendocrine cutaneous malignancy with a predilection for regional and distant metastasis. This malignancy presents most commonly on the head and neck of elderly Caucasian males, with a higher prevalence in the immunosuppressed. A high index of suspicion must be maintained due to the often asymptomatic presentation. Lip tumors, scalp tumors, local invasion, nodal metastasis, distant metastasis, and lymphovascular invasion are poor prognostic factors. Up to 8.7% of patients present with distant metastasis, and PET-CT is an accurate staging tool with a 90% sensitivity. Combined aggressive surgical resection with adjuvant radiotherapy affords the best regional control rates. The regional lymphatics must be addressed with either sentinel lymph node biopsy, surgery, or elective radiation due to the risk of occult metastasis. Addition of chemotherapy has no proven benefit in locoregional control.
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increase the sensitivity of detection of MCPyV in MCC by developing antibodies capable of detecting large T antigen by immunohistochemistry. In addition, we expanded the repertoire of quantitative PCR primers specific for MCPyV to improve the detection of viral DNA in MCC. Here we report that a novel monoclonal antibody detected MCPyV large T antigen expression in 56 of 58 (97%) unique MCC tumors. PCR analysis specifically detected viral DNA in all 60 unique MCC tumors tested. We also detected inactivating point substitution mutations of TP53 in the two MCC specimens that lacked large T antigen expression and in ...
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
TY - JOUR. T1 - Dermoscopy of merkel cell carcinoma. AU - Dalle, Stéphane. AU - Parmentier, Laurent. AU - Moscarella, Elvira. AU - Phan, Alice. AU - Argenziano, Giuseppe. AU - Thomas, Luc. PY - 2012/5. Y1 - 2012/5. N2 - Introduction: Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor whose clinical presentation, usually a pink nodule, is not specific. We aimed in this study to determine the dermoscopic criteria encountered in MCC. Methods: From our image database we selected the patients diagnosed with MCC and scored the dermoscopic criteria shown by these tumors. Results: Ten patients coming from three different academic hospitals were studied. Vascular structures were the more relevant dermoscopic features. In 8 out of 10 (80%) patients a polymorphic vascular pattern was seen, composed of milky-red clods/areas in association with one or more additional vascular structures. Conclusion: Although an overlap existed between the dermoscopic features observed in MCC and amelanotic ...
To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, we analyzed swabs from persons with Merkel cell carcinoma (MCC), others with skin diseases, and healthy volunteers. MCPyV was detected in at least 1 sample from virtually all participants. Viral loads were higher in samples from patients with MCC.
a_benign_virus_normally_found_in_the_skin_can_lead_to_a_type_of_rare_lethal_skin_cancer_specifically_infection_by_the_merkel_cell_polyomavirus_can_lead_to_merkel_cell_carcinoma_in_immunecompromised_individuals_researchers_have_now_identified_a_type_of_skin_cell_as_the_target_of_the_virus_in_humans_this_study_from_the_perelman_school_of_medicine_at_the_university_of_pennsylvania_establis
Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epidermis. Epidermal Atoh1 induction in adolescent mice similarly drove widespread K8 expression in glabrous skin of the paws, but in the whisker pads and body skin ectopic K8+ cells were confined to hair follicles and absent from interfollicular regions. Ectopic K8+ cells acquired several characteristics of mature Merkel cells in a time frame similar to that seen during postnatal development of normal Merkel cells. Although ectopic K8+ cell numbers decreased over time, small numbers of these cells remained in deep regions of body skin hair follicles at 3 months post-induction. In adult mice, greater numbers of ...
Author Summary Polyomaviruses occupy a replicative niche in animals from birds to humans. Two human polyomaviruses, BKV and JCV, were discovered in 1971 and within the last two years, three new polyomaviruses have been found in humans: KI (KIV), WU (WUV), and Merkel Cell (MCV) polyomavirus. MCV was identified in Merkel Cell carcinomas, a rare skin cancer. To date, it has not been determined what percentage of the human population is exposed to KIV, WUV, and MCV, and when initial exposure to these viruses occurs. We determined that initial exposure to KIV, WUV, and MCV occurs in childhood, similar to that for the known human polyomaviruses BKV and JCV, and that their prevalence is high. We also found evidence that a monkey virus, Lymphotropic Polyomavirus (LPV), likely has a serologically related human counterpart. Another monkey polyomavirus, SV40, was found at ∼2% prevalence, a level that does not support its role in human disease.
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A retrospective molecular case-control study was conducted in Non-small-cell lung-cancer patients and their relatives. During the screening program, 106 patient samples (including 77 serum biopsies and 29 parafin embedded tissues) and 90 non-cancer counterparts (50 serum biopsies and 40 parafin embedded tissues) were recruited for being analyzed by realtime-PCR and sequencing. ...
Merkel cell cancer is also known as neuroendocrine cancer of the skin or trabecular cancer. Characterized by firm, shiny skin lumps, this rare cancer develops on or just beneath the skin and in the hair follicles. Merkel cell cancer most often is found on sun-exposed areas of skin, such as the neck and head. The cancer mostly affects Caucasian people over age 50. The cause of the cancer is unknown, but it is believed to be related to both sun exposure and suppression of the immune system.. ...
Merkel cell cancer is also known as neuroendocrine cancer of the skin or trabecular cancer. Characterized by firm, shiny skin lumps, this rare cancer develops on or just beneath the skin and in the hair follicles. Merkel cell cancer most often is found on sun-exposed areas of skin, such as the neck and head. The cancer mostly affects Caucasian people over age 50. The cause of the cancer is unknown, but it is believed to be related to both sun exposure and suppression of the immune system.. ...
Less Common Skin Cancers. Merkel Cell Carcinoma is a rare and aggressive form of skin cancer. It arises from Merkel cells in the lower part of the epidermis. Merkel cells are similar to nerve cells and give the skin touch sensation. Treatment involves a team approach from physicians with significant experience with the disease.. Atypical Fibroxanthoma is thought to arise from the dermis, which is deeper than the epidermis, the source of most other skin cancers. It classically appears on the face or scalp as a reddish, sometimes glistening plaque (broad, raised area on the skin).. Microcystic Adnexal Carcinoma is thought to be derived from cells that produce the adnexal structures, such as hair follicles and sweat glands in the skin. It classically occurs on the face. It may have a deceivingly benign appearance and may be mistaken for a common melanocytic nevus (mole ...
Merkel cells are found in the skin and some parts of the mucosa of all vertebrates. In mammalian skin, they are clear cells found in the stratum basale (at the bottom of sweat duct ridges) of the epidermis approximately 10 μm in diameter. They also occur in epidermal invaginations of the plantar foot surface called rete ridges.[6] Most often, they are associated with sensory nerve endings, when they are known as Merkel nerve endings (also called a Merkel cell-neurite complex). They are associated with slowly adapting (SA1) somatosensory nerve fibers. They react to low vibrations (5-15 Hz) and deep static touch such as shapes and edges. Due to a small receptive field (extremely detailed info) they are used in areas like fingertips the most; they are not covered (shelled) and thus respond to pressures over long periods. ...
Define Merkel disk. Merkel disk synonyms, Merkel disk pronunciation, Merkel disk translation, English dictionary definition of Merkel disk. also disc n. 1. A thin, flat, circular object or plate. 2. Something resembling such an object: The moons disk was reflected in the pond. 3. a.
Only seven human viruses cause nearly 20% of cancers world-wide. Our lab discovered two of these seven viruses: Kaposi sarcoma herpesvirus (KSHV or HHV8) in 1994 and Merkel cell polyomavirus (MCV). We also developed digital transcriptome subtraction, which was the first non-directed mRNA sequencing approach to find new human viruses.. Because cancer viruses contain the genetic information needed to cause cancer, they have been critical to understanding how cancer cells arise, even for those cancers that are not caused by infection. Our lab has two broad focus areas: first, we seek to find new ways to identify human cancer viruses, including high-throughput genomics and proteomics. Second, we study viral oncogenes to understand how they act to turn a healthy cell into a cancer cell.. If you want to learn more, please look at our publications page here for full-text articles. If you are a Pitt student or a postdoc interested in this research, contact us here, or learn more about the Cancer ...
Surgical excision is the gold standard for management of most eyelid and facial skin cancers. A majority of skin cancers in the eyelid area are either basal cell carcinoma or squamous cell carcinoma. Other cancer types (such as sebacous cell carcinoma, malignant melanoma, and Merkel cell carcinoma) occur more infrequently and generally require wider excision, more specialized resection and reconstruction techniques, and a comprehensive oncologic (cancer) evaluation.. There are two basic approaches to basal cell and squamous cell carcinoma excision. Skin cancer removal can be performed at the time of reconstruction and the tumor margins examined (Frozen Sections) by a pathologist to ensure complete removal. Alternatively, microscopic-assisted resection may be performed by a dermatologic surgeon (Mohs Surgery). This technique offers the potential advantages of less tissue removal and slightly greater confidence of complete cancer resection.. Following Mohs skin cancer resection, ...
Rapid restoration of virus-specific T immunity via adoptive transfer of ex vivo generated T cells has been proven as a powerful therapy for patients with advanced cancers and refractory viral infections such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). BK virus (BKV), John Cunningham virus (JCV), and Merkel cell carcinoma virus (MCV) are the members of the rapidly growing human polyomavirus (hPyV) family that commonly infects most healthy humans. These viruses have a clearly established potential for causing severe end-organ damage or malignant transformation, especially in individuals with weakened immunity who are unable to mount or regain endogenous T-cell responses as a result of underlying leukemia or iatrogenic immunosuppression in autoimmunity, bone marrow and solid organ transplant settings ...
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ...
At present, it is in phase III clinical trials at Novartis for the treatment of carcinoid tumors and symptoms that are not adequately controlled by somatostatin analogues (Sandostatin). Phase II clinical development is also under way at the company for the treatment of gastric dumping syndrome, metastatic carcinoid tumors, meningioma and pituitary adenoma and for the treatment of hepatocellular carcinoma in combination with everolimus. Early clinical trials are also ongoing for the treatment of patients with metastatic melanoma or Merkel cell carcinoma. A phase I clinical trial for the treatment of alcoholic cirrhosis has been completed. The company intends to file for approval in 2007 for these indications. Novartis and Thomas Jefferson University are conducting phase II clinical trials for the treatment of prostate cancer, alone or in combination with everolimus. The Mayo Clinic is conducting phase II clinical trials for the treatment of polycystic liver disease. Phase III clinical trials had ...
The UCLA team collaborated with researchers from the Moffitt Cancer Center, the MD Anderson Cancer Center, the University of California San Francisco, Northwestern University Medical Center ...
Friedrich Sigmund Merkel (5 April 1845 - 28 May 1919) was a leading German anatomist and histopathologist of the late 19th century. In 1875, he provided the first full description of Tastzellen (touch cells) which occur in the skin of all vertebrates. They were subsequently given the eponym Merkel cells in 1878 by Robert Bonnet (1851-1921). Merkel was a native of Nürnberg. In 1869 he earned his medical doctorate from the University of Erlangen, becoming habilitated in the field of anatomy during the following year. He was a professor at the Universities of Rostock (from 1872), Königsberg (from 1883), Göttingen (from 1885), and Rostock (from 1872). At Göttingen, he worked under Jacob Henle and married Henles daughter Anne. He published a multivolume textbook on human anatomy and originated the color scheme used by most anatomy texts today: red for arteries, blue for veins, and yellow for nerves. He introduced xylene as a clearing agent in histology, and it is still used today Two of his ...
A 2-year-old Indian girl is suffering from a rare skin disease, lamellar ichthyosis. It affects just one in every 600,000 people.
CANBY, Ore. - An 8-year-old Arkansas boy with a rare skin disorder met a dog in Oregon with the same condition and its something the boy and his mom say they will never forget.
2014 November 6-7: Towards a network of excellence for rare skin diseases in the North Africa and the wider Middle-East area - Beirut - Lebanon (...)
German Chancellor, Angela Merkel, said on Sunday she would meet British Prime Minister, Boris Johnson, on Wednesday evening to discuss Britains planned departure from the European Union.. She added that Berlin was also prepared for a disorderly Brexit.. Johnson is seeking to persuade European Union leaders to reopen Brexit talks or face the prospect of its second-largest member leaving abruptly on Oct. 31 with no deal in place to mitigate the economic shock - a move that businesses expect would cause major disruption.. We are glad of every visit, and you have to talk, and you have to find good solutions, Merkel said during a panel discussion at the Chancellery.. We are prepared for any outcome, we can say that, even if we do not get an agreement. ...
Merkel 147 SL 20 Gauge SxS Shotgun |br >|br > L.L. BEAN 100th ANNIVERSARY, #5 of 20 TOTAL |br >|br > General Specs: Merkel, Year 2 for sale by Vintage Firearms Inc on GunsAmerica - 981124496
An impressive and important paper showing that Merkel Cells use serotonin to signal directly to A-beta afferents. http://www.pnas.org/content/113/37/E5491
We are doing this study to learn if we can lower the chance of your cancer growing back by adding the study drug (Pembrolizumab)... | View the details of this clinical trial.
Disruptions of the sense of touch are inherent to many inherited and acquired human disorders that affect the skin and/or peripheral nervous system. These disor...
Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$30.00. Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.. ...
Hundreds of patients with a type of aggressive skin cancer will be offered a targeted therapy on the NHS in England and Wales, which reduces the risk of it returning. At present, they have to hope their cancer will not return after surgery. The drug has been shown to improve the survival of people with stage III melanoma, with a particular mutation. A skin cancer charity said making the treatment available on the NHS was a huge step forward. Melanoma is the most aggressive type of skin cancer,
Finishing up the last semester of college and simultaneously preparing for a June wedding might seem exciting, if a little daunting.. For Sharon Belvin, health and wellness educator for UPMC Susquehanna, it was a whirlwind of stress and fear.. Belvin was a runner and noticed breathing was becoming more difficult for her rather than getting easier as she got used to her pace.. It got to the point I was huffing and puffing just walking around, she said.. She said time after time health providers passed her breathing trouble off as colds, pneumonia or bronchitis. But, in March of 2004, Belvin noticed a mass below her left collar bone and feared breast cancer.. Instead, a biopsy revealed stage 4 melanoma, an aggressive skin cancer which already had spread to her lungs.. At one point, I had a tumor in my lung the size of a football, Belvin recalled.. She started chemotherapy almost immediately. Though she went through with her wedding, she said she had to scale things back immensely.. Chemo ...
His baseball cap planted for action, his good arm cradling the space where his right arm used to be, Michael Sammy Samuelson walked up to St. Paul Mayor Chris Coleman at a DFL gathering two years ago and told him exactly what he thought of his policies.. The colorful words that spilled out of his mouth were not flattering. Coleman jabbed back, calling Samuelson the most negative man in St. Paul - all said with a smile. Samuelson - a friend and foil to generations of St. Paul political leaders, team owners, radio show hosts and stadium proponents - embraced opportunities to heckle those he considered misinformed, amp up the volume on a debate or otherwise right wrongs with his eccentric, school-boy energy. Samuelson, 57, died Monday, Jan. 29, of complications related to a lifetime of complications, including the aggressive skin cancer that in recent years forced the amputation of his right arm and shoulder. He was diagnosed last year with myelodysplastic syndrome, or MDS, a blood cancer, and ...
In cases where the limbus is destroyed there has been little hope to restore the patients sight. Professor De Lucas team decided to take a leaf from the way that burns are treated and grow a new cornea from limbar stem cells taken from the healthy eye. By removing a small sample of these cells it was possible to culture a new cornea and graft it on to the damaged eye. The team showed that of 240 patients who were operated on in this way, the cornea regenerated successfully in 70% of cases. The researchers then turned their attention to a rare but debilitating genetic disease of the skin resulting in a syndrome known as Epidermolysis Bullosa, in which the skin is highly fragile and prone to blistering due to faulty proteins that effectively anchor the surface layers of skin to the body. In one form of the disease there is a mutation in one of these anchoring proteins called laminin 5. The Italian researchers obtained consent to carry out a small-scale trial of a novel gene therapy using skin ...
Sara Geurts was diagnosed with a connective tissue disorder called Ehlers-Danlos Syndrome, which means she lacks collagen in her skin.
Cheri and Phillip Lindsay both have a rare condition that causes them to gradually lose skin pigment in patches. But it was easier for her to deal with it, Cheri says, because of her dads example.
The Health Department said there have been 30 reported cases of the infection caused by a bacterium called Mycobacterium marinum.
DOC --| Over 60 patient representatives from 30 countries gathered for the official launch and inaugural meeting of Rare Diseases International (...)
IN THE PAPERS : INTERNATIONAL PAPERS, Fri. 08/06/12: German Chancellor Angela Merkel wants more political integration within the EU.
Almanya Başbakanı Angela Merkel, başkent Berlinde düzenlediği basın toplantısında korona virüs salgınından, ülkede etkili olan sel felaketine ve Türkiye ile
Germans in the northern state of Schleswig-Holstein went to the polls on Sunday (May 7) that the Social Democrat party are hoping to win in order to beat Chancellor Angela Merkel in Septembers national election. Rough cut (no reporter...}
Chancellor Angela Merkel urged German employers to help get more women back to work after they become mothers in a country that needs to boost its workforce - unlike much of Europe, where mass unemployment is putting pressure on political leaders.
Germanys Angela Merkel stressed the importance of Europe striking a free trade deal with the United States on Saturday, but added she would not allow the import of chlorine-washed chicken - a sticking point in negotiations.
Lira is a very large female with excellent temperament. She loves when children visit so she can hang out with them. In conformation she has always been first except for the Sieger show when she was pulled out 2nd and went 5th because of her large size. Since then she has been retired from the Show Ring to the whelping box where she produced the 2007 WDA VA Matcho vom Zellwaldrand SchH3, Kkl 1a. She now has 20 titled kids, and 30 titled grandkids! Obviously I cannot keep up with the titled great grand kids....her worth as a top producer goes beyond numbers!!!. See - V Puma vom Haus Merkel SchH2, Kkl 1a ...
Important: This site has been set up to provide viewers information the various products and services offered by Merkel Technologies Ltd. All images are copyrighted to their respective owners ...
Para mbledhjes së Këshillit Evropian në Bruksel, Kancelarja Merkel u tregon vendin britanikëve: në daljen e tyre nga BE ata nuk do të mund të zgjedhin çfarë të duan nga BE. SPD kërkon një ofensivë investimesh në Evropë.
"Merkel cell carcinoma". Journal of the National Comprehensive Cancer Network. 7 (3): 322-32. doi:10.6004/jnccn.2009.0024. PMID ... His work has also extended to serving on expert panels such as those dedicated to merkel cell cancer and guidelines of care. He ... Alam, Murad; Ratner, Désirée (2001). "Cutaneous Squamous-Cell Carcinoma". New England Journal of Medicine. 344 (13): 975-83. ...
... the virus seemed to move from cell to cell, but by around the 12th day, lysis of many infected cells occurred and the virus was ... ACAM2000s virus is cultured in kidney epithelial cells (Vero cells) from an African green monkey. Efficacy and adverse reaction ... Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ... Poxviruses are unique among DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus. In ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Potential systemic absorption of imiquimod, with negative effects on white blood cell counts overall, and specifically ... which consist of large cells with abundant granular eosinophilic cytoplasm (accumulated virions) and a small peripheral nucleus ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Cell-mediated immune responses are also important in limiting the scope and the duration of primary varicella infection. After ... VZV then remains latent in the dorsal ganglion cells of the sensory nerves. Reactivation of VZV results in the clinically ...
"KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics". Viruses. 8 (11): ... Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ... Once the virus newly infects a cell, the lipid membrane is shed and the virion travels to the nucleus. The viral genome is ... KSHV is a rhadinovirus, and is remarkable since it has stolen numerous genes from host cells including genes that encode for ...
The virus infects the cells in the epidermal layer of the skin. The initial viral replication occurs at the entry site in the ... Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ... The virus moves to the nerve cells from where it can reactivate. Once the condition has recurred, it is normally a mild ... and then it goes to the nuclei of the cells and reproduces or replicates.[9] The blisters and ulcers formed on the skin are a ...
Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ... George and Gladys Dick showed that cell-free filtrates could induce the erythematous reaction characteristic of scarlet fever, ... because they are able to cause an extensive immune response within the body through activation of some of the main cells ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... Histologically, the epithelial cells show signs of intracellular and extracellular edema.[citation needed] ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... Inflammation (day 1): Virus begins reproducing and infecting cells at the end of the nerve. The healthy cells react to the ... Post-scab (12-14 days): A reddish area may linger at the site of viral infection as the destroyed cells are regenerated. Virus ...
Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ...
Merkel cell polyomavirus *Merkel cell carcinoma. RNA virus. Paramyxoviridae. *MeV *Measles. Togaviridae. *Rubella virus * ... Low numbers of white blood cells may also be present.[1] ...
"Merkel cell carcinoma and Azzopardi phenomenon". Am J Dermatopathol. 29 (3): 314-5. doi:10.1097/DAD.0b013e318033901b. PMID ... It can occur in small cell carcinomas and in some high-grade malignant neoplasms. The effect is well known in diagnostic ... Azzopardi JG (1959). "Oat-cell carcinoma of the bronchus". J Pathol Bacteriol. 78 (2): 513-9. doi:10.1002/path.1700780218. PMID ... Case Studies Azzopardi phenomenon in a metastatic small cell carcinoma of the lung. ...
"Overview - Merkel cell carcinoma - Mayo Clinic". www.mayoclinic.org. "Michael Wilson, former finance minister, ambassador, to ...
"Merkel cell carcinoma and HIV infection." The Lancet 359, no. 9305 (2002): 497-498. "Morten Frisch". SSI. Retrieved 21 August ...
Orouji E, Peitsch WK, Orouji A, Houben R, Utikal J (January 2020). "6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma". ... A recent study demonstrates the presence of m6A in the small T antigen of Merkel cell polyomavirus (MCPyV) in Merkel cell ... Mammalian viral transcripts must function in a mammalian cell, so they must acquire the same epigenetic marks as the host cell ... Nevertheless, m6A levels vary between different RNAs within a cell and between different cell types of the same organism. The ...
Merkel cell carcinoma. Alexander Kibrik, 73, Russian linguist (Moscow State University), after long illness. Fernando Ortíz, 89 ... Naoki Miyamoto, 77, Japanese professional Go player, hepatocellular carcinoma. Natina Reed, 32, American musician (Blaque) and ... Mohammed Mushaima, 24, Bahraini political activist, sickle cell anemia. Kalambadi Muhammad Musliyar, 78, Indian Muslim scholar ...
Results of a Phase II clinical trial in Merkel-cell carcinoma were reported in The New England Journal of Medicine in June 2016 ... Nghiem (2016). "PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma". N. Engl. J. Med. 374 (26): 2542-2552. doi: ... in Participants With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, or Non-small Cell Lung Carcinoma (P07990/ ... the PD-1 receptor on activated T-cells binds to ligands PD-L1 or PD-L2 on other cells, deactivating a potential T-cell-mediated ...
About 80% of Merkel cell carcinomas are caused by Merkel cell polyomavirus; the remaining tumors have an unknown etiology and ... Merkel cell polyomavirus is the most recently discovered human cancer virus, isolated from Merkel cell carcinoma tissues in ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... Inflammation triggered by the worm's eggs appears to be the mechanism by which squamous cell carcinoma of the bladder is caused ...
"Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid ... "Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine ... "Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma". Journal of the National Cancer ... and Merkel cell virus (MCV) with Merkel cell cancer. SV40 replicates in the kidneys of monkeys without causing disease, but can ...
... naturally infects humans and is associated with Merkel cell carcinoma (MCC), a rare form of skin cancer originating from Merkel ... of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells". Cell. ... "Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma". Science. 319 (5866): 1096-1100. Bibcode:2008Sci... ... the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to ...
... and was used to discover Merkel cell polymavirus in Merkel cell carcinoma. Simultaneously to the MCV discovery, this approach ... Feng H, Shuda M, Chang Y, Moore PS (Jan 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". Science. ... the suspect causative agent in Merkel cell carcinoma. Using computational subtraction to discover novel pathogens was first ... The method specifically examines the etiological agent of infectious diseases and is best known for discovering Merkel cell ...
This virus is the likely cause of Merkel-cell carcinoma and hence is named Merkel cell polyomavirus. Moore and Chang have ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... two different human viruses causing the AIDS-related cancer Kaposi's sarcoma and the skin cancer Merkel cell carcinoma. The ... they identified the most recently discovered human polyomavirus infecting Merkel cells. ...
... and Epstein-Barr virus causing B cell lymphomas and nasopharyngeal carcinomas. Kaposi sarcoma virus and Merkel cell polyoma ... T lymphocytes are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells from ... The carcinoma cells still harbour the viral genes and antigens. As expected T cell responses against antigens encoded by genes ... This enables the T cells to eliminate cells with "foreign" or "abnormal" antigens without harming the normal cells. It has long ...
... merkel cell carcinoma. Claes Egnell, 95, Swedish sport shooter and Olympic silver medal-winning (1952) pentathlete. Manuel ...
... small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported ... It comprises the CD56-binding antibody, lorvotuzumab (huN901), with a maytansinoid cell-killing agent, DM1, attached using a ... "ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung ... encouraging Phase II results for small-cell lung cancer. Dimond PF (9 March 2010). "Antibody-Drug Conjugates Stage a Comeback ...
David Brudnoy, 64, American radio talk show host (Boston), Merkel cell carcinoma. Paul Edwards, 81, Austrian-born American ...
DTS was used to isolate DNA fragments of Merkel cell polyomavirus from a Merkel cell carcinoma and it is now believed that this ... but a recently discovered analogue called Merkel cell polyomavirus has been associated with Merkel cell carcinoma, a form of ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... Forcing the cell into the S phase of the cell cycle could cause the cell to become transformed. Human papillomavirus infection ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Studies have found heightened HPV in mouth cell samples from people with squamous cell carcinoma of the mouth. Studies have not ... Thus, inactivation of p53 by E6 can promote unregulated cell division, cell growth, and cell survival, characteristics of ... "Genus β human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control ...
Shortly after these performances, on 11 September 2007, Zawinul died of Merkel cell carcinoma. The Veszprém concert was ...
Samlowski WE, Becker J. The Potential for Targeted Therapy of Merkel Cell Carcinoma. In Merkel Cell Carcinoma: A ... A Phase II trial of imatinib mesylate (Gleevec) in neuroendocrine carcinoma of the skin (Merkel Cell Carcinoma) (S0331). ... "A phase II trial of imatinib mesylate in Merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology ... "A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ... the increased production of oily sebum causes the dead skin cells to stick together.[10] The accumulation of dead skin cell ...
As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has ... Mahr AD, Neogi T, Merkel PA (2006). "Epidemiology of Wegener's granulomatosis: Lessons from descriptive studies and analyses of ... Rudnick DA, Perlmutter DH (September 2005). "Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in ... which could confer this protein particular protein-cell recognition properties. The single cysteine residue of A1AT in position ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... For example, JCV has been found to infect the granule cell layer of the cerebellum, while sparing purkinje fibers, ultimately ...
Merkel-cell carcinoma. *Mesothelioma. *Metastasis. *Metastatic breast cancer. *Multiple myeloma. *Myelofibrosis. N. * ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt ... The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the ... However, such encapsulation tends to prevent immune cells from attacking bacteria in the pus, or from reaching the causative ...
squamous cell carcinoma. *basal cell carcinoma. *merkel cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... Brain magnetic resonance imaging showing primary central nervous system B-cell non-Hodgkin lymphoma of the sella turcica and ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Li TJ, Cui J (August 2013). "COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma". Asian Pacific ... It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[12][33] ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... "High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa". International Journal of Oral Science ...
Squamous-cell carcinoma. *Basal-cell carcinoma. *Merkel-cell carcinoma. *Nevus sebaceous. *Trichoepithelioma ... Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ... The relative increase in percentage of CD8+ T cells, caused by a reduction in numbers of CD4+ T cells may be implicated in RAS- ... Mast cells and macrophages are also involved, secreting TNF-α along with the T cells. When early aphthous ulcers are biopsied, ...
... transitional cell carcinoma of the bladder or other malignancies.[29] Myeloproliferative neoplasms, including acute leukemia, ... Monach PA, Arnold LM, Merkel PA (January 2010). "Incidence and prevention of bladder toxicity from cyclophosphamide in the ... Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts ... subsequently actively transported into cancer cells. Once in the cells, the prodrug was enzymatically converted into the active ...
en:Merkel-cell carcinoma (11). *en:Mesothelioma (27) → 중피종 *en:Metabolic disorder (11) ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Cell death signaling. *Apoptosis is increased in monocytes and keratinocytes. *Expression of Fas by B cells and T cells is ... This material may present a threat to the tolerization of B cells and T cells. Dendritic cells in the germinal center may ... Early apoptotic cells express "eat-me" signals, of cell-surface proteins such as phosphatidylserine, that prompt immune cells ...
Squamous-cell carcinoma. *Basal-cell carcinoma. *Merkel-cell carcinoma. *Nevus sebaceous. *Trichoepithelioma ... The B cell endocytoses the complex and presents the modified gliadin to the activated Th1 cell's T cell receptor (TCR) via pMHC ... These T cells become activated and polarised into type I helper T (Th1) cells. Th1 cells reactive towards gliadin have been ... Once the B cell becomes activated, it differentiates into plasma cells that secrete autoantibodies against tTG, which may be ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... The epidermis contains four cell types: keratinocytes, melanocytes, Langerhans cells, and Merkel cells. Of these, keratinocytes ... about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an ... in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
Merkel cell carcinoma. *Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma ... with squamous cell carcinoma being the most common type. The incidence of squamous cell carcinoma increases to 37% when the ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... Tenderness at the base of the lesion is often a clue to the presence of a possible underlying squamous cell carcinoma.[citation ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... Entry into host cells occur through complex interactions between virions, especially through their glycoproteins, and cell- ...
Merkel cell polyomavirus(英语:Merkel cell polyomavirus) *Merkel cell carcinoma(英语:Merkel cell carcinoma) ... MCPyV(英语:Merkel cell polyomavirus) Merkel-cell carcinoma(英语:Merkel-cell carcinoma). 核糖核酸病毒. C型肝炎病毒(英语:Hepatitis C virus) 肝細胞癌. ... 濾泡性樹突狀細胞肉瘤(英语:Follicular dendritic cell sarcoma). Extranodal NK/T-cell lymphoma, nasal type(英语:Extranodal NK/T-cell lymphoma, ... 成
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Though the cells of calluses are dead, they are quite resistant to mechanical and chemical insults due to extensive networks of ... A callus also can refer to an undifferentiated plant cell mass grown on a culture medium, which can be put into a bioreactor to ... produce genetically identical cells. This is a type of tissue culture, and can be started from almost any part of the plant, ...
Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal ... basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant melanoma. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... and squamous-cell carcinoma.[38] There is little evidence that it is effective in preventing basal-cell carcinoma.[39] Other ...
September 2007). "Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas". Cancer Cell. 12 (3): ... Derrien, T.; Johnson, R.; Bussotti, G.; Tanzer, A.; Djebali, S.; Tilgner, H.; Guernec, G.; Martin, D.; Merkel, A.; Knowles, D. ... "Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells". Cell Stem Cell. 18 (5): 637-652. ... which is explained by higher cell-to-cell variation of expression levels of lncRNA genes in the individual cells, when compared ...
Merkel cell carcinoma. Eye[edit]. *Uveal melanoma. *Retinoblastoma. Gastrointestinal[edit]. *Anal cancer ... such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma.[citation needed] ... cancers are additionally classified by the type of cell that the tumor cells originated from. These types include: *Carcinoma: ... Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... These hemagluttinin proteins bind to sialic acid receptors on host cells, which can fall into two categories. The sialic acid ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Pigment Cell Research. 16 (2): 90-100. doi:10.1034/j.1600-0749.2003.00023.x. PMID 12622785.. ... ultrathin epidermal sheets and basal cell layer suspension". The British Journal of Dermatology. 147 (5): 893-904. doi:10.1046/ ... This results in the destruction of skin pigment cells.[2] Risk factors include a family history of the condition or other ...
Learn about Merkel cell skin cancer diagnosis tests here. ... Merkel Cell Carcinoma Stages * Survival Rates for Merkel Cell ... Tests for Merkel Cell Carcinoma. Most skin cancers, including Merkel cell carcinoma (MCC), are brought to a doctors attention ... Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. J Am Acad Dermatol. 2018;78(3):433-442. ... For more on this test and what the results could mean, see Surgery for Merkel Cell Carcinoma. ...
This guide will help you learn about possible causes of Merkel cell skin cancer. ... Many risk factors may increase your chance of developing Merkel cell skin cancer. ... Merkel cell polyomavirus (MCV) infection. The Merkel cell polyomavirus (MCV) is found in the cancer cells of about 8 out of 10 ... Merkel Cell Carcinoma Risk Factors. A risk factor is anything that raises your chance of getting a disease such as cancer. ...
... squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. Merkel cell carcinomas ... Media related to Merkel cell carcinoma at Wikimedia Commons National Cancer Institute. "Merkel Cell Carcinoma". National ... "Immunotherapy for Merkel Cell Carcinoma , Merkel Cell Carcinoma". Retrieved 2020-05-14. Clinical trial number NCT01913691 for " ... In 1878 the term Merkel cell was coined by the anatomist Robert Bonnet (1851-1921). Merkel-cell carcinoma was first described ...
Inc.) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). ... Inc.) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). ...
Question concerns Merkel Cell Carcinoma and CLL. Patient is 63 yo male, dxd with prostate cancer 95 and treated with seeds. ... Merkel Cell Carcinoma Metastasis. Question concerns Merkel Cell Carcinoma and CLL. Patient is 63 yo male, dxd with prostate ... Patient dxd with Merkel Cell Carcinoma 07. Merkel cell treated unsuccessfully with chemo and successfully with radiation. ... Patient dxd with Merkel Cell Carcinoma 07. Merkel cell treated unsuccessfully with chemo and successfully with radiation. ...
The authors also acknowledge support from the Merkel cell carcinoma patient gift fund at University of Washington; the Kelsey ... Upfront immunotherapy with pembrolizumab (Keytruda, Merck & Co) in patients with advanced Merkel cell carcinoma (aMCC) shows an ... Immunotherapy Should Be First Line in Merkel Cell Carcinoma - Medscape - Mar 18, 2019. ... Fast Five Quiz: How Much Do You Know About Merkel Cell Carcinoma? ...
... the genetic material of a virus into normal human skin cells to produce skin cells that have features of Merkel Cell Carcinoma ... identify the embryonic origin of Merkel cells. Their research continue on an extremely aggressive cancer, the Merkel cell ... Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma Researchers at the University of ... a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma. ...
Merkel cell carcinoma (MCC) is when these cells multiple and grow … ... Merkel cells, found in the top layer of the skin, are touch receptors. They are found in high concentrations on the fingertips ... Merkel cell carcinoma (MCC) is when these cells multiple and grow out of control. It starts most often in areas of the body ... Frequently Asked Questions About Merkel Cell Carcinoma, Date Unknown, Staff Writer, Merkelcell.org ...
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumor of the skin with a mortality rate of approximately 25% ( ... S. Brodsky, J. S. Zager, and C. G. Berman, "Imaging of merkel cell carcinoma," in Merkel Cell Carcinoma: A Multidisciplinary ... To date, there is still no imaging algorithm for Merkel cell carcinoma. Due to the rarity of Merkel cell carcinoma imaging, ... algorithms in patients with Merkel cell carcinoma and no widely accepted guidelines for imaging of Merkel cell carcinoma are ...
If Merkel cell carcinoma does come back, unusual skin changes can often be detected in their earliest stages during follow-up ... Merkel cell carcinoma survivors are also advised to complete regular self-exams to check for the potential signs of a ... Because Merkel cell carcinomas are uncommon and the warning signs can be difficult to detect, survivors are encouraged to find ... Anyone who is displaying signs of a potential Merkel cell carcinoma recurrence can turn to Moffitt Cancer Center for prompt ...
... more than half of the patients with an aggressive form of skin cancer called Merkel cell carcinoma responded to the ... About 80 percent of Merkel cell carcinomas are associated with infection by a virus called Merkel cell polyomavirus (MCPyV). ... The Merkel cell carcinoma study raises the question of whether other viruses that are associated with cancer produce antigens ... In a small clinical trial, more than half of the patients with an aggressive form of skin cancer called Merkel cell carcinoma ...
Merkel cell carcinoma of the head and neck is a rare and aggressive malignant tumour. Both the dermatological and surgical ... Potential secondary Merkel cell carcinoma in the head and neck region should be taken into account when planning short- and ... Secondary Merkel Cell Carcinoma Manifested in the Parotid. M. Basati, K. Kassam, and A. Messiha ... Histological analysis confirmed Merkel cell carcinoma and consequently surgical excision was carried out. A follow-up PET/CT ...
Its not clear what causes Merkel cell carcinoma. Merkel cell carcinoma begins in the Merkel cells. Merkel cells are found at ... Merkel cell carcinoma. Merkel cell carcinoma. Merkel cell carcinoma is a rare, aggressive skin cancer. It appears as a painless ... Merkel cell carcinoma is also called neuroendocrine carcinoma of the skin.. Merkel cell carcinoma most often develops in older ... Even with treatment, Merkel cell carcinoma commonly spreads (metastasizes) beyond the skin. Merkel cell carcinoma tends to ...
The development of Merkel cell carcinoma is associated with other skin cancers, such as basal cell carcinoma and squamous cell ... Excessive exposure to ultraviolet (UV) light - UV light can damage the DNA in skins cells. In most cases, Merkel cell carcinoma ... Older age - While Merkel cell carcinoma can occur at any age, it is diagnosed most often in individuals who are age 50 or older ... Whether or not an individual has one or more Merkel cell carcinoma risk factors, its important to always be vigilant for signs ...
stage I Merkel cell carcinomastage II Merkel cell carcinoma. Treatment of Stage I and Stage II Merkel Cell Carcinoma. For ... Merkel Cell Carcinoma Treatment. General Information About Merkel Cell Carcinoma. Key Points for this Section. *Merkel cell ... Merkel cell carcinoma is a very rare disease in which malignant (cancer) cells form in the skin.. Merkel cells are found in the ... For example, if Merkel cell carcinoma spreads to the liver, the cancer cells in the liver are actually cancerous Merkel cells. ...
Detection of Merkel cell polyomavirus in Merkel cell carcinomas and small cell carcinomas by PCR and immunohistochemistry. ... Houben R, Shuda M, Weinkam R, Schrama D, Feng H, Chang Y. Merkel cell polyomavirus-infected Merkel cell carcinoma cells require ... in distinguishing between Merkel cell polyomavirus-positive and Merkel cell polyomavirus-negative Merkel cell carcinomas. Hum ... Type I and II IFNs inhibit Merkel cell carcinoma via modulation of the Merkel cell polyomavirus T antigens. Cancer Res. 2012 ...
Merkel cell carcinoma.. Multidisciplinary Patient Care. Your team of Merkel cell carcinoma experts include surgeons, medical ... Merkel cell carcinoma is a rare type of skin cancer. It is also known as primary neuroendocrine carcinoma of the skin, ... The Merkel cell carcinoma center at Mass General Cancer Center is actively pursuing several lines of investigation into Merkel ... The Merkel cell carcinoma center at Mass General Cancer Center is actively pursuing several lines of investigation into Merkel ...
Merkel Cell Carcinoma Treatment. Merkel cell carcinoma. General Information About Merkel Cell Carcinoma. Merkel cell carcinoma ... Merkel Cell Carcinoma Merkels Cell Carcinoma Small Cell Carcinoma Tonsillar Squamous Cell Cancer in Dogs Squamous Cell ... recurrent Merkel cell carcinoma. Recurrent Merkel Cell Carcinoma Treatment. Merkel cell carcinoma is a rare tumor. There are no ... stage III Merkel cell carcinoma. Stage III Merkel Cell Carcinoma Treatment. Stage III Merkel cell carcinoma (MCC)includes ...
... approval of avelumab the treatment of patients 12 years and older with metastatic Merkel cell carcinoma. ... Avelumab in Merkel Cell Carcinoma FDA medical oncologists discuss the agencys March 23, 2017, ... Merkel cell carcinoma is a rare, aggressive neuroendocrine tumor of the skin. Prior to the approval of avelumab, there were no ... But for rare skin cancers such as Merkel cell carcinoma, there have been no FDA approved drugs until avelumab. So it was a ...
Get detailed information about the diagnosis and treatment of newly diagnosed and recurrent Merkel cell carcinoma in this ... Merkel cell carcinoma treatment options include surgery, radiation therapy, and chemotherapy. ... General Information About Merkel Cell Carcinoma Go to Patient Version Merkel cell carcinoma (MCC) was originally described by ... Recurrent Merkel Cell Carcinoma Treatment. Merkel cell carcinoma is a rare tumor. There are no clinical trials reported for ...
... including rare skin cancers like Merkel cell carcinoma. We also have experience in managing complex, multiple, and recurrent ... Merkel Cell Carcinoma More About Merkel Cell Carcinoma Diagnosis & Treatment at Memorial Sloan Kettering ...
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) ... genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated ... Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. Scott J. Rodig, … , Linda C. Wang, James A. ...
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) ... Western blot with Ab3 or CM2B4 of cell lysates prepared from MCC cell lines showing a predominant signal for truncated large T ... MCPyV genome copy number in cell lines with indicated qPCR primer sets. All values were normalized to MKL-2. Error bars ... genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated ...
... immunotherapy drug and radiation could help patients with Merkel cell carcinoma. ... New Triple Drug Combination Helps Treat Merkel Cell Carcinoma. Merkel Cell Carcinoma caused by Merkel cell polyomavirus is a ... New Test to Detect Merkel Cell Carcinoma Recurrence. New findings show how immune system marker can help and often outperform ... Triple Immunotherapy for Merkel Cell Carcinoma An experimental combination of three different therapies for the rare skin ...
... for the treatment of adult and pediatric patients over the age of 12 with metastatic Merkel cell carcinoma, including those who ... "While skin cancer is one of the most common cancers, patients with a rare form called Merkel cell cancer have not had an ... Overall, 65.9 percent of patients were PD-L1-positive and 52.3 percent were positive for the Merkel cell polyomavirus (MCPyV). ... FDA Approves Bavencio for Merkel Cell Carcinoma. @media screen and (max-width: 468px) { .video-detail .doc-group-container { ...
... Bavencio (avelumab), a PD-L1-inhibitor, gained approval by the Food and Drug ... for the treatment of adult and pediatric patients over the age of 12 with metastatic Merkel cell carcinoma, including those who ... "While skin cancer is one of the most common cancers, patients with a rare form called Merkel cell cancer have not had an ... Overall, 65.9 percent of patients were PD-L1-positive and 52.3 percent were positive for the Merkel cell polyomavirus (MCPyV). ...
MC polyomavirus is frequently present in Merkel cell carcinoma of European patients.. Becker JC, Houben R, Ugurel S, Trefzer U ... Getting stronger: the relationship between a newly identified virus and Merkel cell carcinoma. [J Invest Dermatol. 2009] ... Carcinoma, Merkel Cell/diagnosis*. *Carcinoma, Merkel Cell/epidemiology. *Carcinoma, Merkel Cell/virology* ...
Carcinoma, Merkel Cell. Carcinoma. Skin Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms ... Cabozantinib in Recurrent/Metastatic Merkel Cell Carcinoma. The safety and scientific validity of this study is the ... Must have histologically or cytologically confirmed Merkel Cell Carcinoma that is metastatic or unresectable and for which ... Genetic and Rare Diseases Information Center resources: Merkel Cell Carcinoma Neuroendocrine Tumor Neuroepithelioma ...
Approved for Merkel Cell Carcinoma in Japan. *First-ever treatment indicated for curatively unresectable Merkel cell carcinoma ... About Merkel Cell Carcinoma MCC is a rare and aggressive disease in which cancer cells form in the top layer of the skin, close ... NCCN Merkel Cell Carcinoma Guidelines version I. 2017.. BAVENCIO Prescribing Information. 2017. Rockland, MA: EMD Serono Inc. ... Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs. European Journal of Cancer 2017;71;53-69. ...
Health-related quality of life in patients with Merkel cell carcinoma (MCC) can be improved when treated with the anti-PD-L1 ... Merkel Cell Carcinoma. Merkel cell carcinoma is a rare and a highly aggressive primary skin cancer that grows rapidly and is ... The oncoprotein that allows a common and harmless virus to transform healthy cells Merkel Cell Carcinoma (MCC) has been ... Lymph Node Biopsy Proves Effective in Patients With Merkel Cell Carcinoma. Sentinel lymph node biopsy (SNLB) procedure shows ...
  • However, others have argued that MCC likely derives from an epithelial precursor cell due to its frequent presence in mixed tumors including epithelial neoplasms such as squamous cell carcinoma. (wikipedia.org)
  • Merkel cell polyomavirus (MCPyV) occurs in the majority (~80%) of MCC tumors, and the persistent expression of MCPyV T-antigen oncoproteins is required for virus-positive (VP) tumor cells to proliferate. (medscape.com)
  • Ultrasonographic features of Merkel cell carcinoma appear similar to more common skin tumors such as melanoma or basal cell carcinoma [ 8 ]. (hindawi.com)
  • The drug, one of a class of therapies known as immune checkpoint inhibitors, removes this brake on the immune system, allowing certain immune cells to attack tumors. (cancer.gov)
  • High levels of viral DNA and clonal integration of the virus in MCC tumors have also been reported along with expression of certain viral antigens in MCC cells and the presence of antiviral antibodies. (oncolink.org)
  • In this trial, 88 patients with metastatic Merkel Cell tumors, previously treated with one line of chemotherapy, were treated with avelumab, 10 mg/kg intravenously every two weeks. (fda.gov)
  • The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. (jci.org)
  • Immunoblot analysis revealed collectively high protein levels of prosurvival Bcl-2 members in cell lines and a panel of MCC tumors. (nih.gov)
  • Merkel cell tumors manifest in two distinct forms. (bioportfolio.com)
  • The trial demonstrated that avelumab works in patients with highly mutated cancers typically caused by UV light and also in those with minimally mutated tumors triggered by the Merkel cell polyomavirus. (nursingcenter.com)
  • In the current phase II trial, 32% of patients with metastatic Merkel cell carcinoma experienced partial or complete shrinkage of their tumors when treated with avelumab, which is an anti-PD-L1 monoclonal antibody. (cancernetwork.com)
  • Researchers have found that the protein targeted by avelumab (PD-L1) is overexpressed by many Merkel cell tumors. (cancernetwork.com)
  • In addition, most Merkel cell tumors are associated with a virus called Merkel cell polyomavirus, which integrates its DNA into a healthy cell's DNA, compromising the immune response. (cancernetwork.com)
  • In the avelumab trial, some patients responded even if their tumors didn't overexpress PD-L1 or were not positive for the Merkel cell polyomavirus. (cancernetwork.com)
  • In cancer immunology, our quantitative pathology solutions play a critical role in understanding a tumor's immune profile: defining the relationships and distribution of cells within tumors and within the tumors' microenvironment and providing the data needed to advance the exciting and paradigm-shifting area of immuno-oncology. (news-medical.net)
  • Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. (sigmaaldrich.com)
  • Using whole transcriptome gene expression signatures and a computational bioinformatic approach, we identified significant differences between variant cell lines (UISO, MCC13, and MCC26) and fresh frozen MCC tumors. (sigmaaldrich.com)
  • Conversely, the classic WaGa and Mkl-1 cell lines more closely represented the global transcriptome of MCC tumors. (sigmaaldrich.com)
  • When compared with publicly available cancer lines, WaGa and Mkl-1 cells were similar to other neuroendocrine tumors, but the variant cell lines were not. (sigmaaldrich.com)
  • WaGa and Mkl-1 cells grown as xenografts in mice had histological and immunophenotypical features consistent with MCC, whereas UISO xenograft tumors were atypical for MCC. (sigmaaldrich.com)
  • Our results validate the use of transcriptome analysis to assess the cancer cell line representativeness and indicate that UISO, MCC13, and MCC26 cell lines are not representative of MCC tumors, whereas WaGa and Mkl-1 more closely model MCC. (sigmaaldrich.com)
  • The researchers found that the immune cells traveled from the bloodstream to the tumors. (cancernetwork.com)
  • In addition, the cells stayed at the tumor sites for months, even when the tumors were no longer clinically detectable. (cancernetwork.com)
  • MCPyV was detected in 19 of 23 (74%) primary MCC tumors, but 8 of these had less than 1 viral copy per 300 cells. (rti.org)
  • The Merkel cell polyomavirus oncoprotein serology test is useful in surveillance, as it helps detect recurrences in seropositive patients and suggests regular imaging is important for seronegative patients, whose tumors are more likely to recur. (ascopost.com)
  • The presence of a trabecular pattern helps to differentiate Merkel cell carcinoma (MCC) from other small round blue cell (SRBC) tumors, and specificity approaches that achieved with immunostaining, a recent study found. (mdedge.com)
  • A comparison of the histopathologic growth patterns between non-Merkel cell small round blue cell tumors and Merkel cell carcinoma. (mdedge.com)
  • We studied T cells in MCC to determine how these virally mediated tumors evade immune responses. (harvard.edu)
  • MCC tumors were infiltrated by T cells, including effector, central memory and increased numbers of CD4 and CD8 FOXP3+ regulatory T cells. (harvard.edu)
  • Treatment of MCC tumors in vitro with IL-2 and IL-15 led to T cell activation, proliferation, enhanced cytokine production and loss of viable tumor cells from cultures. (harvard.edu)
  • MCC tumors implanted into immunodeficient NOD/SCID/IL2 receptor g chainnull mice failed to grow unless human T cells in the tumor grafts were depleted with denileukin diftitox, suggesting tumor-specific T cells capable of controlling tumor growth were present in MCC. (harvard.edu)
  • In summary, we observed tumor-specific T cells with suppressed activity in MCC tumors. (harvard.edu)
  • Merkel cell polyomavirus (MCPyV) DNA was detected in 88% of Merkel cell carcinomas in contrast to 16% of other skin tumors. (cdc.gov)
  • Garneski KM , Warcola AH , Feng Q , Kiviat NB , Leonard JH , Nghiem P . Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. (cdc.gov)
  • Merkel's cell tumors usually present as firm and painless skin lumps and generally are found on the sun-exposed areas of the face or scalp but can occur anywhere on the body. (oncolink.org)
  • Merkel cell polyomavirus is frequently involved in the development of MCC and is present in about 80% of MCC tumors tested. (nih.gov)
  • [3] While DNA changes ( mutations ) found in the cells of MCC tumors can lead to MCC, these types of mutations are not inherited from a person's parents. (nih.gov)
  • We identified T lymphocytes (CD3-positive cells), T-cell subsets (CD4, CD8, and FoxP3-positive cells), natural killer cells (small CD16-positive cells), and macrophages (CD68 and CD163-positive cells) in tumors of 116 individuals diagnosed with MCC in Finland from 1979 to 2004 using immunohistochemistry and detected MCPyV DNA with quantitative PCR. (aacrjournals.org)
  • The effect of different types of immune cells on outcome is of particular interest in MCC, as these tumors can be divided into viral infection-associated and nonassociated tumors. (aacrjournals.org)
  • FDA medical oncologists discuss the agency's March 23, 2017, approval of avelumab the treatment of patients 12 years and older with metastatic Merkel cell carcinoma. (fda.gov)
  • But for rare skin cancers such as Merkel cell carcinoma, there have been no FDA approved drugs until avelumab. (fda.gov)
  • SB: Avelumab was granted accelerated approval based on data from an open-label, single-arm, multi-center trial (the JAVELIN Merkel 200 trial). (fda.gov)
  • 1.1 Avelumab is recommended as an option for treating metastatic Merkel cell carcinoma in adults, only if they have had 1 or more lines of chemotherapy for metastatic disease. (nice.org.uk)
  • Bavencio (avelumab), a PD-L1-inhibitor, gained approval by the Food and Drug Administration (FDA) for some patients with Merkel cell carcinoma. (curetoday.com)
  • Bavencio (avelumab), a PD-L1-inhibitor, gained approval by the Food and Drug Administration (FDA) for the treatment of adult and pediatric patients over the age of 12 with metastatic Merkel cell carcinoma, including those who have never had chemotherapy. (curetoday.com)
  • Merck KGaA, Darmstadt, Germany, and Pfizer Inc. (NYSE: PFE) today announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has approved BAVENCIO® (avelumab, genetically recombinant Injection 200mg/mL for intravenous use) as the first and only treatment indicated for curatively unresectable Merkel cell carcinoma (MCC), a rare and aggressive cancer, in Japan. (pfizer.com)
  • Merkel cell carcinoma (MCC) can be treated with the anti-PD-L1 immunotherapy avelumab that delays progression and improves health-related quality of life (HRQoL) of these patients, reveals a new study. (medindia.net)
  • Treating Merkel cell carcinoma (MCC) patients with avelumab can improve their quality of life. (medindia.net)
  • Merck KGaA and Pfizer Inc. announced that the U.S. FDA granted Breakthrough Therapy Designation for avelumab in combination with Inlyta (axitinib) treatment-naïve patients with advanced renal cell carcinoma. (pharmalive.com)
  • The U.S. FDA approved Bavencio (avelumab) Injection 20 mg/mL for ttreating adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma. (pharmalive.com)
  • WASHINGTON - The immunotherapeutic avelumab (Bavencio) was well tolerated by patients with advanced Merkel cell carcinoma, and the majority of those whose cancer responded to avelumab treatment had durable responses, according to results from a phase II clinical trial presented here at the AACR Annual Meeting 2017 , April 1-5. (aacr.org)
  • Kaufman explained that avelumab targets the PD-L1 protein and that the rationale for treating patients with Merkel cell carcinoma with the immunotherapeutic came from studies showing that PD-L1 is found on tumor samples from nearly all patients with this form of cancer. (aacr.org)
  • The findings of long-term responses and well-tolerated safety profile suggest that avelumab could be an important new agent for patients with Merkel cell carcinoma who have failed prior chemotherapy," said Kaufman. (aacr.org)
  • Avelumab monotherapy showed durable antitumor activity and manageable safety in patients with metatastic Merkel cell carcinoma that progressed after chemotherapy. (nursingcenter.com)
  • An experimental checkpoint inhibitor called avelumab may produce quick and durable responses in some patients with metastatic Merkel cell carcinoma. (cancernetwork.com)
  • An experimental checkpoint inhibitor called avelumab may produce quick and durable responses in some patients with metastatic Merkel cell carcinoma, a rare, aggressive skin cancer with few effective treatments, according to results from a new phase II study published September 1, 2016, in Lancet Oncology . (cancernetwork.com)
  • Through this CRADA, NCI performed early preclinical studies of avelumab that evaluated its efficacy and produced promising results, and NCI published data showing avelumab's ability to mediate antibody-dependent, cell-mediated cytotoxicity (ADCC). (federallabs.org)
  • Results from the study directly led to the FDA's accelerated approval of avelumab for the treatment of previously treated, locally advanced or metastatic urothelial carcinoma. (federallabs.org)
  • Also, the safety data of the study supported the FDA's accelerated approval of avelumab for the treatment of metastatic Merkel cell carcinoma (MCC), a rare and aggressive skin cancer with fewer than half of patients surviving more than one year and fewer than 20% surviving beyond 5 years, representing a significant unmet need. (federallabs.org)
  • In a poster that will be presented (abstract 3044 ) June 5 at the 2017 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, the research team reported on the use of T-cell therapy combined with avelumab and either radiation or interferon. (cancernetwork.com)
  • In two related phase I/II studies, the researchers examined the safety and efficacy of ex vivo expanded Merkel cell polyomavirus (MCPyV)-specific T cells plus human leukocyte antigen upregulation (radiation or interferon) with and without avelumab. (cancernetwork.com)
  • In the current study, the addition of avelumab appeared to kick the T cells into high gear, according to Paulson. (cancernetwork.com)
  • On March 23, 2017, avelumab (Bavencio) was granted accelerated approval for treatment of patients aged ≥ 12 years with metastatic Merkel cell carcinoma. (ascopost.com)
  • Approval was based on the finding of clinically meaningful and durable responses in an open-label, single-arm, multicenter trial (JAVELIN Merkel 200 trial) in which 88 patients received avelumab at 10 mg/kg via intravenous infusion over 60 minutes every 2 weeks until disease progression or unacceptable toxicity. (ascopost.com)
  • Avelumab has also been shown to induce antibody-dependent cell-mediated cytotoxicity in vitro and decreased tumor growth via PD-L1 inhibition in syngeneic mouse models. (ascopost.com)
  • EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) Injection 20 mg/mL, for intravenous use, for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma (mMCC). (pfizer.com)
  • Planegg-Martinsried, Germany, 21 October 2019 - 4SC AG (4SC, FSE Prime Standard: VSC) today announced that a poster entitled: The preclinical rationale and clinical design for the combination of domatinostat with avelumab in Merkel Cell Carcinoma patients: the MERKLIN 1 and MERKLIN 2 studies by Dr. René Bartz will be presented at the 1st International Symposium on Merkel Cell Carcinoma 21-22 October 2019, Tampa, Florida, USA. (pharmiweb.com)
  • The Phase II open label, multicenter MERKLIN 2 and 1 clinical studies will be initiated by 4SC in Q4 2019 and Q1, 2020 respectively and will evaluate the combination of domatinostat and the PD-L1 checkpoint inhibitor avelumab in patients with advanced Merkel-cell carcinoma. (pharmiweb.com)
  • In preclinical and human clinical studies conducted by NantKwest, the combination of haNK cells with a number of different therapeutic antibodies, including avelumab, led to enhanced tumor cell killing when compared to the use of the antibody alone. (biospace.com)
  • The PD-L1 checkpoint inhibitor avelumab, a monoclonal antibody developed by Merck KGaA and approved in 2017 by the FDA, targets the programmed death-ligand 1 protein (PD-L1), commonly expressed on a wide range of cancer cells. (biospace.com)
  • Avelumab works by blocking PD-L1 from binding PD-1 receptors on T-cells, resulting in an increase in CD8+ T-cell immune responses. (biospace.com)
  • The Phase II clinical study will evaluate a combination therapy with our off-the-shelf CD16-targeted natural killer cells (haNK), the IL-15 superagonist (N-803), and avelumab, without the use of cytotoxic chemotherapy, in subjects with MCC that have progressed on or after treatment with a checkpoint inhibitor. (biospace.com)
  • The trial, headed by Dr Shahneen Sandhu, will involve patients with Merkel Cell Carcinoma (MCC) and will test the immunotherapy drug Avelumab in combination with either radionuclide therapy or external beam radiotherapy. (petermac.org)
  • Merck and Pfizer today announced that the US Food and Drug Administration (FDA) has granted avelumab*, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, Fast Track designation for the treatment of metastatic Merkel cell carcinoma (MCC), a rare and aggressive type of skin cancer. (andhranews.net)
  • We are pleased that the FDA continues to acknowledge the current high unmet needs for patients with metastatic Merkel cell carcinoma through these recent regulatory designations for avelumab," said Dr. Luciano Rossetti, Head of Global Research & Development at Merck's biopharmaceutical business, Merck Serono. (andhranews.net)
  • We look forward to working with our partners at Merck on the development of avelumab in patients with relapsed and refractory Merkel cell carcinoma," said Dr. Mace Rothenberg, Senior Vice President of Clinical Development and Medical Affairs and Chief Medical Officer for Pfizer Oncology. (andhranews.net)
  • The designation relates to the clinical development program for avelumab in metastatic MCC, which includes the Phase II study, JAVELIN Merkel 200, to assess the safety and efficacy of avelumab in patients with metastatic MCC who have progressed after at least one prior chemotherapy regimen. (andhranews.net)
  • On 23 March 2017, the US Food and Drug Administration (FDA) granted accelerated approval to the programmed death receptor 1 ligand (PD-L1) inhibitor avelumab (Bavencio®, EMD Serono, Inc.) for the treatment of adult and pediatric patients (12 years and older) with metastatic Merkel cell carcinoma (MCC), including those patients who have not received prior treatment with chemotherapy. (primeoncology.org)
  • Avelumab is the first approved treatment option for Merkel cell carcinoma. (primeoncology.org)
  • Approval is based on results from the open-label phase II JAVELIN Merkel 200 trial (n = 88), in which treatment with avelumab demonstrated clinically meaningful and durable responses in patients with previously treated metastatic MCC. (primeoncology.org)
  • Merck and Pfizer Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended the approval of avelumab (BAVENCIO ® ) as a monotherapy for the treatment of adult patients with metastatic Merkel cell carcinoma (mMCC), a rare and aggressive skin cancer. (bionity.com)
  • Merck and Pfizer Inc. today announced that the European Commission (EC) has granted marketing authorization for BAVENCIO(R) (avelumab) as a monotherapy for the treatment of adult patients with metastatic Merkel cell carcinoma (mMCC), a rare and aggressive skin cancer. (perssupport.nl)
  • Avelumab showed early positive survival data and lasting responses for patients with pretreated advanced or metastatic Merkel cell carcinoma, according to findings from the phase II JAVELIN Merkel 200 trial presented at the 2016 ASCO Annual Meeting. (targetedonc.com)
  • Prior to the release of the data, avelumab had received a breakthrough therapy designation for avelumab as a potential treatment for patients with Merkel cell carcinoma. (targetedonc.com)
  • Clinical results support the use of avelumab as a new therapeutic option for advanced or metastatic Merkel cell carcinoma patients,' said lead investigator Howard L. Kaufman, MD, Rutgers Cancer Institute. (targetedonc.com)
  • Avelumab showed durable antitumor activity in patients with chemotherapy-refractory metastatic Merkel cell carcinoma. (targetedonc.com)
  • Avelumab was well-tolerated in this second-line or greater Markel cell carcinoma population,' said Kaufman. (targetedonc.com)
  • In addition to Merkel cell carcinoma, avelumab is also being explored across a variety of other types of cancer that have shown susceptibility to PD-L1 inhibition. (targetedonc.com)
  • February 22, 2018 - MISSISSAUGA, ON - EMD Serono, Canada, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the U.S. and Canada, and Pfizer Canada announced that Health Canada has approved BAVENCIO™ (avelumab for injection) for the treatment of metastatic Merkel cell carcinoma (MCC) in previously treated adults. (pfizer.ca)
  • The U.S. Food and Drug Administration on March 23 approved the immunotherapy drug avelumab for metastatic Merkel cell carcinoma (MCC) - a rare, aggressive form of skin cancer - for adults and patients 12 years of age and older. (cancer.gov)
  • Avelumab binds to PD-L1, preventing the T cells from being switched off so they can still attack tumor cells. (cancer.gov)
  • Unlike existing anti-PD-1/PD-L1 immunotherapies, high concentrations of avelumab bound to PD-L1 on tumor cells can also trigger tumor killing by natural killer (NK) cells - netting "two shots on the goal," explains James Gulley , M.D., Ph.D., Chief, Genitourinary Malignancies Branch . (cancer.gov)
  • Preclinical research at CCR demonstrated that avelumab allows T cells to efficiently kill a variety of tumor cells and can enlist the help of NK cells. (cancer.gov)
  • They saw no significant decrease in the defensive cells after treatment, evidence that avelumab does not have harmful effects on the immune system. (cancer.gov)
  • At CCR, where research labs spanning multiple disciplines neighbor world-class clinical facilities, investigators could rapidly translate preclinical findings on avelumab into human trials and confirm in those same patients that avelumab does not destroy immune cells, all within a few corridors. (cancer.gov)
  • Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation. (wikipedia.org)
  • About 80 percent of Merkel cell carcinomas are associated with infection by a virus called Merkel cell polyomavirus (MCPyV). (cancer.gov)
  • Significant overexpression of the Merkel cell polyomavirus (MCPyV) large T antigen in Merkel cell carcinoma. (medscape.com)
  • In 2008, a novel polyomavirus (Merkel cell polyoma virus, MCPyV) was first reported in MCC tumor specimens , a finding subsequently confirmed in other laboratories. (oncolink.org)
  • Detection of MCPyV in MCC cell lines. (jci.org)
  • C ) MCPyV genome copy number in cell lines with indicated qPCR primer sets. (jci.org)
  • Overall, 65.9 percent of patients were PD-L1-positive and 52.3 percent were positive for the Merkel cell polyomavirus (MCPyV). (curetoday.com)
  • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer, which is associated in 80% of cases with the Merkel cell polyomavirus (MCPyV). (bioportfolio.com)
  • Merkel cell polyomavirus (MCPyV) has been detected in about 80% Merkel cell carcinomas tested. (dermnetnz.org)
  • It was reported that Merkel Cell Polyomavirus (MCPyV) shows presence in MCCs [ 4 , 5 , 6 , 7 ] and viral DNA was integrated within the tumor genome in a clonal pattern [ 5 , 8 ]. (mdpi.com)
  • We have shown RASSF1A promoter methylation and MCPyV presence in small cell lung cancer [ 10 ]. (mdpi.com)
  • In non-small cell lung cancer MCPyV presence was found together with increased BRAF and decreased Bcl2 levels [ 11 ]. (mdpi.com)
  • I. Determine the safety and potential toxicities associated with treating patients with metastatic merkel cell carcinoma (MCC) by combined myosin heavy chain (MHC) up-regulation therapy and adoptive transfer of merkel cell polyomavirus (MCPyV) T-antigen (TAg)-specific polyclonal autologous cluster of differentiation (CD)8+ T cells. (clinicaltrials.gov)
  • Determine the antitumor efficacy associated with treating patients with metastatic MCC by combined MHC up-regulation therapy and adoptive transfer of MCPyV TAg-specific polyclonal autologous CD8+ T cells. (clinicaltrials.gov)
  • I. Determine the in vivo persistence and where evaluable, migration to tumor sites of adoptively transferred polyclonal CD8+ T cells targeting the MCPyV TAg. (clinicaltrials.gov)
  • Determine the in vivo functional capacity of adoptively transferred polyclonal CD8+ T cells targeting the MCPyV TAg. (clinicaltrials.gov)
  • Patients receive MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine intravenously (IV) on day 1 and aldesleukin subcutaneously (SC) every 12 hours on days 1-14. (clinicaltrials.gov)
  • Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC), a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells. (rti.org)
  • To investigate this heterogeneity, we developed a tissue microarray (TMA) to characterize immunohistochemical staining of candidate tumor cell proteins and a quantitative PCR assay to detect MCPyV and measure viral loads. (rti.org)
  • Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinomas (MCC), rare but aggressive skin cancers ( 1 ). (cdc.gov)
  • In oral samples, MCPyV DNA was detected in 39% of normal swabs, in 0% of benign lesions, and in 50% of carcinomas in situ. (cdc.gov)
  • Merkel cell carcinoma (MCC) is a rare skin cancer that often harbors Merkel cell polyomavirus (MCPyV) DNA. (aacrjournals.org)
  • The clinical importance of intratumoral immune cells and their associations with MCPyV infection are poorly understood. (aacrjournals.org)
  • The associations between immune cell counts, MCPyV DNA, patient and tumor characteristics, and patient outcome were examined. (aacrjournals.org)
  • Although the numbers of T cells are generally higher in MCPyV-positive than in MCPyV-negative MCC, high intratumoral T-cell counts are also associated with favorable survival in MCPyV-negative MCC. (aacrjournals.org)
  • This study shows that MCCs that contain MCPyV DNA often contain high numbers of intratumoral immune cells. (aacrjournals.org)
  • Interestingly, a high intratumoral CD3 + cell count was associated with favorable survival also in the subset of patients whose MCC did not contain MCPyV DNA. (aacrjournals.org)
  • The results indicate that tumor CD3 + cell count is a new prognostic factor in MCC and suggest that the host immune defense also influences the outcome of those patients whose MCC is not associated with MCPyV infection. (aacrjournals.org)
  • Most MCCs harbor Merkel cell polyomavirus (MCPyV) DNA, which is involved in the molecular pathogenesis of the disease ( 2-4 ). (aacrjournals.org)
  • MCPyV-negative MCCs express p53 and harbor TP53 gene mutations more frequently than MCPyV DNA-positive carcinomas ( 12 ). (aacrjournals.org)
  • The approval is based on data from the phase 2 JAVELIN Merkel 200 study, which was presented at the 2016 ASCO Annual Meeting and published in the Lancet Oncology . (curetoday.com)
  • The JAVELIN Merkel 200 study enrolled 88 previously treated patients with metastatic MCC. (curetoday.com)
  • This approval is based on data from JAVELIN Merkel 200, an international, multicenter, single-arm, open-label, Phase II study in patients with metastatic MCC. (pfizer.com)
  • The JAVELIN Merkel 200 study is the largest registrational clinical trial for an immunotherapy in metastatic MCC. (pfizer.com)
  • The efficacy and safety of BAVENCIO was demonstrated in the JAVELIN Merkel 200 trial, a Phase II, open-label, single-arm, multicenter study, in metastatic MCC. (pfizer.com)
  • In this study, the researchers utilized data from the JAVELIN Merkel 200 Phase II trial. (medindia.net)
  • The efficacy and safety of BAVENCIO was demonstrated in the JAVELIN Merkel 200 trial, an open-label, single-arm, multi-center study conducted in 88 patients with histologically confirmed metastatic MCC whose disease had progressed on or after chemotherapy administered for distant metastatic disease. (pfizer.com)
  • The Health Canada approval of BAVENCIO is based on results of the JAVELIN Merkel 200 trial, an open-label, single-arm, multi-centre phase II study conducted in 88 patients with metastatic MCC whose disease had progressed after at least one chemotherapy treatment for distant metastatic disease. (pfizer.ca)
  • Nearby lymph nodes , which are bean-sized collections of immune system cells under the skin will also be closely checked. (cancer.org)
  • Merkel-cell cancers tend to invade locally, infiltrating the underlying subcutaneous fat, fascia, and muscle, and typically metastasize early in their natural history, most often to the regional lymph nodes. (wikipedia.org)
  • stage I is defined by local disease without lymph node involvement or distant metastases, in stage II carcinoma has spread to lymph nodes but no systemic metastases are detectable, and in stage III distant metastases are detectable [ 9 ]. (hindawi.com)
  • Merkel cell carcinoma tends to travel first to nearby lymph nodes. (mayoclinic.org)
  • Because Merkel cell carcinoma has a high rate of spreading to regional lymph nodes and distant areas of the body, we recommend a PET/CT (Positron Emission Tomography/Computed Tomography) or a CT plus an MRI (Magnetic Resonance Imaging) of the brain to look for evidence of distant disease. (massgeneral.org)
  • Merkel cell carcinoma can spread to regional lymph nodes as well as distant sites in the body. (emedicinehealth.com)
  • Merkel cell carcinoma may also spread to lymph nodes in the neck, axillae and groin. (dermnetnz.org)
  • Longterm survival is likely if the lymph nodes do not contain tumour cells. (dermnetnz.org)
  • Since Merkel cell carcinoma (MCC) often quickly spreads to nearby lymph nodes , the nodes are examined once a diagnosis is confirmed. (skincancer.org)
  • Lymph nodes are glands that are part of your lymphatic system where your white blood cells form, and where lymph, a clear fluid containing your white blood cells, is filtered. (skincancer.org)
  • If cancer cells are discovered, the surgeon may opt to remove all local lymph nodes or destroy them with radiation therapy. (skincancer.org)
  • This carcinoma is characterized by a high incidence of local recurrence (12%-50%), involvement of the locoregional lymph nodes (17%-76%), distant metastases, and a high lethality rate (20%-55%) 3-9 . (scielo.br)
  • Much more commonly than melanoma, Merkel cell carcinoma microscopically metastasizes to the lymph nodes and to distant sites. (ascopost.com)
  • However, melanoma and Merkel cell carcinoma are very likely to spread to the lymph nodes or other parts of the body. (allure.com)
  • Treatment of Merkel cell carcinoma usually involves surgery to remove the tumor, often followed by radiation therapy , removal or biopsy of lymph nodes, or both. (merckmanuals.com)
  • Merkel's cell cancer most commonly spreads to the local lymph nodes as well as the liver, bone, lungs, and brain. (oncolink.org)
  • 2,3 This primary neuroendocrine carcinoma has remarkable metastatic potential (34%-75%) and can invade regional lymph nodes, as well as distant metastasis most commonly to the liver, lungs, bones, and brain. (mdedge.com)
  • The aim of the procedure is to remove lymph nodes from one side of the neck into which cancer cells may have migrated. (intelligentdental.com)
  • Metastasis of squamous cell carcinoma into the lymph nodes of the neck reduce survival and is the most important factor in the spread of the disease. (intelligentdental.com)
  • Merkel cell carcinoma: an Australian perspective and the importance of addressing the regional lymph nodes in clinically node-negative patients. (springermedizin.at)
  • It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. (wikipedia.org)
  • Merkel cell carcinoma is also called neuroendocrine carcinoma of the skin. (mayoclinic.org)
  • Merkel cell carcinoma , also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when Merkel cells grow out of control. (oncolink.org)
  • MCC is an aggressive neuroendocrine carcinoma arising in the dermoepidermal junction (see Figure 1). (oncolink.org)
  • MCC is an aggressive neuroendocrine carcinoma arising in the dermoepidermal junction (see Figure 1 ), and it is the second most common cause of skin cancer death after melanoma. (cancer.gov)
  • 4],[5] MCC, which is also known as neuroendocrine carcinoma of the skin or trabecular cancer, often starts in those areas of the skin that are most often exposed to the sun, including the head and neck, and arms. (pfizer.com)
  • A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. (bioportfolio.com)
  • It has also been called Toker tumour , cutaneous neuroendocrine carcinoma, trabecular cell carcinoma, and primary small-cell carcinoma of the skin. (dermnetnz.org)
  • Neuroendocrine carcinoma. (scielo.br)
  • Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma, a dermal neoplasm with cytoplasmic, dense-core neuroendocrine granules and keratin filaments. (medscape.com)
  • Several factors are involved in the pathophysiology of MCC, including a virus called Merkel cell polyomavirus (MCV), ultraviolet radiation (UV) exposure, and weakened immune function. (wikipedia.org)
  • Other names include Toker tumor, primary small cell carcinoma of the skin, primary cutaneous neuroendocrine tumor, and malignant trichodiscoma. (oncolink.org)
  • Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. (nih.gov)
  • Merkel cell carcinoma (MCC), a rare but aggressive cutaneous neoplasm with high metastatic potential, has a poor prognosis at late stages of disease with no proven chemotherapeutic regimens. (nih.gov)
  • Merkel cell carcinoma (MCC) is a relatively rare and aggressive cutaneous neuroendocrine malignancy. (bioportfolio.com)
  • Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. (nih.gov)
  • Merkel Cell Carcinoma (MCC) is a rare but aggressive cutaneous malignancy [ 1 ] of the elderly with poor prognosis [ 2 ]. (mdpi.com)
  • Merkel cell carcinoma is a rare, aggressive, malignant primary cutaneous neuroendocrine tumor. (scielo.br)
  • A subset of these MCC studies investigated the presence of MCV in other types of nonmelanoma skin cancers for comparison with MCC ( 3-6 ), such as cutaneous squamous cell carcinoma (SCC). (aacrjournals.org)
  • Merkel cell carcinoma is an aggressive neuroendocrine cutaneous malignancy with a predilection for regional and distant metastasis. (mdpi.com)
  • Merkel cell carcinoma (MCC), an uncommon cutaneous neuroendocrine malignancy, is a rare cause of spinal metastasis, with only five cases previously reported. (ovid.com)
  • Merkel cells are slow-responding mechanoreceptors located within the basal layer of the epidermis and are the source of a rare aggressive cutaneous malignancy. (mdedge.com)
  • Earlier this year, the US Food and Drug Administration (FDA) granted accelerated approval* for BAVENCIO for the treatment of mMCC and patients with locally advanced or metastatic urothelial carcinoma (UC) who have disease progression during or following platinum-containing chemotherapy. (pfizer.com)
  • Patients with metastatic Merkel cell carcinoma are usually treated with chemotherapy, but the cancer nearly always recurs within six months, at which point life expectancy is only about three to six months. (aacr.org)
  • Given the lack of effective treatment options for patients with metastatic Merkel cell carcinoma whose cancer has recurred after chemotherapy, we are excited to see such a high objective response rate. (aacr.org)
  • Kaufman and colleagues enrolled 88 patients with metastatic Merkel cell carcinoma that had progressed after treatment with chemotherapy in the phase II clinical trial. (aacr.org)
  • Patients with Merkel cell carcinoma often require a combination of surgery, chemotherapy, and radiation therapy. (dana-farber.org)
  • 3 All patients had metastatic Merkel cell carcinoma with disease progression on or after chemotherapy for metastatic disease. (ascopost.com)
  • Today is a significant milestone for people fighting metastatic Merkel cell carcinoma, who until now have not had any options beyond chemotherapy," said Albert Bourla, Group President, Pfizer Innovative Health. (pfizer.com)
  • The goal of combining these therapies is to synergistically maximize the killing of cancer cells while attempting to spare patients from chemotherapy and its associated adverse side effects. (biospace.com)
  • This multicenter, single-arm, open-label study is being conducted in patients with metastatic Merkel cell carcinoma (mMCC), a rare and aggressive type of skin tumor,[1],[2] who have previously received one line of chemotherapy. (presseportal.de)
  • Surgery, radiotherapy and chemotherapy have all been used in the treatment of merkel's cell cancer. (oncolink.org)
  • and in May 2017 for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy therapy, or who have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. (bionity.com)
  • Metastatic MCC is generally treated with small cell lung cancer chemotherapy regimens, because the tumor consists of neuroendocrine cells, but patients generally do not have durable responses. (scirp.org)
  • MCC is sometimes mistaken for other histological types of cancer, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. (wikipedia.org)
  • Compared with malignant melanoma, Merkel cell carcinoma tends to spread more aggressively and is several times more likely to be lethal than melanoma. (cancer.gov)
  • Merkel cell carcinoma is the second most common cause of skin cancer death after melanoma . (oncolink.org)
  • Merkel cell carcinoma, a rare type of skin cancer, is an aggressive and fast-growing disease that has been associated with mortality rates higher than other types of skin cancer, including melanoma," said Scot Ebbinghaus, MD, vice president of clinical research at Merck Laboratories. (ajmc.com)
  • Like melanoma , the prognosis for Merkel cell carcinoma that has spread is poor. (emedicinehealth.com)
  • Merkel cell carcinoma (MCC) is 40 times more rare than melanoma, with an estimated one case per 130,000 people in the U.S. (skincancer.org)
  • WASHINGTON, D.C.-Up until recently, patients with advanced Merkel cell carcinoma (MCC) had little hope of a durable treatment for their rare, aggressive skin condition, which is considered more deadly than melanoma. (nursingcenter.com)
  • Merkel cell carcinoma has an estimated incidence of 0.23 per 100,000 people in Caucasian populations, which is much less common than melanoma . (dermnetnz.org)
  • Merkel cell carcinoma, which metastasizes rapidly, is one of the most aggressive skin cancers, with a mortality rate of 33 percent, exceeding that of melanoma, and a 45 percent five-year survival rate. (biologynews.net)
  • This study also found that the FDA-approved drug trametinib for melanoma and other cancers blocks viral infection by stopping Merkel cell polyomavirus transcription and replication. (biologynews.net)
  • The average melanoma (0.6-mm Breslow depth) and the average Merkel cell carcinoma (1.7 cm in diameter) pose strikingly different risks of spread. (ascopost.com)
  • One in three such Merkel cell carcinoma patients has microscopic nodal involvement on sentinel lymph node biopsy, compared to fewer than 1 in 50 patients with an average melanoma. (ascopost.com)
  • Merkel cell carcinoma is a rare but often lethal skin cancer that is much more likely to metastasize than melanoma. (ascopost.com)
  • To put it in perspective, they estimate that cases of Merkel cell carcinoma (MCC) are rising six times faster than other types of skin cancers and twice as fast as melanoma. (allure.com)
  • Together, these two factors make Merkel cell cancers even deadlier than melanoma. (allure.com)
  • According to the Skin Cancer Foundation, Merkel cell cancers kill about one in three patients , compared to one in nine patients who die from melanoma. (allure.com)
  • While signs of skin cancer, including melanoma, are relatively easy to recognize, Merkel cell cancers are more likely to fly under the radar. (allure.com)
  • Merkel cell carcinoma is rarer than some of the more well-known skin cancers, however, it's very aggressive and the proportion of people who die from MCC is much higher than that of people with melanoma," said Deborah S. Sarnoff, MD, President of the Skin Cancer Foundation. (pfizer.com)
  • Other risk factors include cumulative exposure to ultraviolet light, exposure to the Merkel cell polyomavirus, and having another cancer (eg, multiple myeloma, chronic lymphocytic leukemia, melanoma ). (merckmanuals.com)
  • 7] This study is currently recruiting patients into expansion cohorts in seven cancer types: castrate-resistant prostate cancer, colorectal cancer, gastric/gastroesophageal cancer, melanoma, metastatic breast cancer, non-small cell lung cancer and ovarian cancer. (presseportal.de)
  • FDA approvals in ovarian cancer, Merkel cell carcinoma, immune thrombocytopenia, and of a biosimilar, and a European approval in melanoma. (onclive.com)
  • CT-guided biopsy reveals mixed composition tumor 90/10 CLL and Merkel cell, respectively. (medhelp.org)
  • Consensus seems to be that risk of CT-guided biopsy (a second one) outweighs the benefits of identifying the makeup of the tumor mass since we understand that no more radiation can be given and chemo is ineffective on Merkel cells. (medhelp.org)
  • Patients with Merkel cell carcinoma are staged by history and physical exam, radiographic imaging and sentinel lymph node biopsy. (massgeneral.org)
  • In addition, we recommend that patients undergo a biopsy of a lymph node or a few nodes that drain the area of the primary (original skin tumor) Merkel cell carcinoma. (massgeneral.org)
  • Sentinel lymph node biopsy (SNLB) procedure shows positive results in patients with Merkel Cell Carcinoma. (medindia.net)
  • A biopsy is done to confirm the diagnosis of Merkel cell carcinoma. (merckmanuals.com)
  • Diagnosis of Merkel cell carcinoma is by biopsy. (merckmanuals.com)
  • Biopsy revealed Merkel cell carcinoma. (radiopaedia.org)
  • Merkel cell carcinoma showing regression after biopsy: evaluation of programmed cell death 1-positive cells [published online February 24, 2015]. (mdedge.com)
  • Shibayama Y, Imafuku S, Takahashi A, Nakayama J. Role of sentinel lymph node biopsy in patients with Merkel cell carcinoma: statistical analysis of 403 reported cases. (springermedizin.at)
  • Most skin cancers, including Merkel cell carcinoma (MCC), are brought to a doctor's attention because of signs or symptoms a person is having. (cancer.org)
  • Finally, the presence of B-cell surface markers on MCC in addition to the high correlation between MCC and B-cell lymphomatous cancers have also led to suggestions that MCC may share a progenitor with B-cells. (wikipedia.org)
  • Leeds-based scientists, funded by Yorkshire Cancer Research headquartered in Harrogate, North Yorkshire, plan to introduce the genetic material of a virus into normal human skin cells to produce skin cells that have features of Merkel Cell Carcinoma cancers. (news-medical.net)
  • Merkel cell carcinoma is associated with the development of other skin cancers, such as basal cell or squamous cell carcinoma. (mayoclinic.org)
  • Each team member has expertise in evaluating and treating patients with cancers of the skin - including rare skin cancers like Merkel cell carcinoma. (mskcc.org)
  • While skin cancer is one of the most common cancers, patients with a rare form called Merkel cell cancer have not had an approved treatment option until now," Richard Pazdur, M.D., acting director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research and director of the FDA's Oncology Center of Excellence said in a statement. (curetoday.com)
  • Today's announcement demonstrates our continued determination to provide access to our immunotherapy for people around the world living with hard-to-treat cancers such as Merkel cell carcinoma. (pfizer.com)
  • It is often similar in appearance to other more common skin cancers such as basal cell carcinoma but grows much more quickly. (dermnetnz.org)
  • Merkel cell carcinoma (MCC) is one of the most aggressive cancers of the skin. (mdpi.com)
  • The rise is concerning for two major reasons: First, Merkel cell cancers are incredibly aggressive, meaning they're more likely to metastasize and harder to cure. (allure.com)
  • The most common skin cancers - basal cell cancer and squamous cell cancer - can usually be cured with surgery and only rarely spread beyond the skin,' explains Paulson. (allure.com)
  • The second reason to be concerned is that Merkel cell cancers have a high risk of recurrence, according to the Skin Cancer Foundation . (allure.com)
  • Merkel cell cancers kill about one in three patients. (allure.com)
  • Merkel cell carcinomas (MCC) are rare but highly malignant skin cancers associated with a novel polyomavirus. (harvard.edu)
  • Merkel cell carcinoma: incidence, mortality, and risk of other cancers. (andhranews.net)
  • Treatment of 26 patients with advanced previously untreated Merkel cell carcinoma with Keytruda® (pembrolizumab) every three weeks resulted in an overall response rate of 56% suggesting this novel therapy could represent a new treatment option for these hard to treat cancers. (unm.edu)
  • Presence of tumor infiltrating lymphocytes, especially of cytotoxic T cells, is associated with favorable prognosis in a number of human cancers ( 3, 4 , 10, 11 ). (aacrjournals.org)
  • Researchers recently discovered that a common virus plays a role in causing most cases of Merkel cell carcinoma. (mayoclinic.org)
  • In most cases of Merkel cell carcinoma (about 80%), Merkel cell polyomavirus is clonally integrated in the tumor cells, and viral oncoproteins drive oncogenesis. (ascopost.com)
  • Squamous cell cancer is the second most common type of skin cancer. (medindia.net)
  • squamous cell carcinoma , later showing extensive local recurrence. (bioportfolio.com)
  • These cases illustrate that Merkel cell carcinoma is capable of divergent differentiation, including squamous and adnexal morphologies. (bioportfolio.com)
  • Merkel cell polyomavirus (MCV) DNA has been reported in 0% to 25% of squamous cell carcinomas (SCC) occurring in immunocompetent individuals. (aacrjournals.org)
  • The neck dissection is a surgical procedure for control of neck lymph node metastasis from Squamous cell carcinoma ( SCC ) and Merkel cell carcinoma ( MCC ) of the head and neck. (intelligentdental.com)
  • The Merkel cell polyomavirus (MCV) is found in the cancer cells of about 8 out of 10 people with MCC. (cancer.org)
  • This can lead to skin cancer when this ongoing damage affects the DNA of genes that control skin cell growth. (cancer.org)
  • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about 3 people per 1,000,000 members of the population. (wikipedia.org)
  • Hi, CLL as you rightly mentioned is a cancer of blood cells. (medhelp.org)
  • Merkel cell carcinoma on the other hand is a neuroendocrine cancer of the skin. (medhelp.org)
  • Docs do not know why Merkel tumor is shrinking as it is a very aggressive cancer. (medhelp.org)
  • Researchers at the University of Pittsburgh Cancer Institute (UPCI) have identified the oncoprotein that allows a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma. (news-medical.net)
  • ImmunoGen, Inc., a biotechnology company that develops antibody-based anticancer products using its Targeted Antibody Payload (TAP) technology, today announced the initiation of a randomized Phase I/II clinical trial to evaluate its proprietary product candidate, IMGN901 (lorvotuzumab mertansine), for first-line treatment of small-cell lung cancer (SCLC) in patients with extensive disease. (news-medical.net)
  • While it's impossible to predict whether Merkel cell carcinoma will return, anyone who has been diagnosed with skin cancer should be especially vigilant about participating in routine screenings. (moffitt.org)
  • Because Merkel cell carcinomas are uncommon and the warning signs can be difficult to detect, survivors are encouraged to find an oncologist who has significant experience in treating unusual forms of skin cancer. (moffitt.org)
  • Anyone who is displaying signs of a potential Merkel cell carcinoma recurrence can turn to Moffitt Cancer Center for prompt diagnosis and treatment. (moffitt.org)
  • In a small clinical trial, more than half of the patients with an aggressive form of skin cancer called Merkel cell carcinoma responded to the drug pembrolizumab (Keytruda®), which strengthens the immune response against cancer. (cancer.gov)
  • When cancer arises among certain skin cells, it can take on the look of normal Merkel cells, whose roles include mediating touch sensation. (cancer.gov)
  • The Merkel cell carcinoma study raises the question of whether other viruses that are associated with cancer produce antigens that stimulate the immune system to reject a tumor, Dr. Topalian explained. (cancer.gov)
  • Merkel cell carcinoma is a rare, aggressive skin cancer. (mayoclinic.org)
  • Merkel cell carcinoma is a rare type of skin cancer that usually appears as a flesh-colored or bluish-red nodule, often on your face, head or neck. (mayoclinic.org)
  • Treatment options for Merkel cell carcinoma often depend on whether the cancer has spread beyond the skin. (mayoclinic.org)
  • Given that the virus is very common and Merkel cell carcinoma is very rare, it's likely that other risk factors play a role in the development of this cancer. (mayoclinic.org)
  • While exposure to sunlight isn't proved to cause Merkel cell carcinoma, it is considered a risk factor for this cancer. (mayoclinic.org)
  • Merkel cell carcinoma risk factors are behaviors, exposures, conditions and characteristics that can increase an individual's likelihood of developing this relatively rare type of skin cancer. (moffitt.org)
  • Many people have one or more risk factors and never develop cancer, while others who are diagnosed with Merkel cell carcinoma have no known risk factors. (moffitt.org)
  • Whether or not an individual has one or more Merkel cell carcinoma risk factors, it's important to always be vigilant for signs of skin cancer. (moffitt.org)
  • Merkel cell carcinoma is a rare type of skin cancer that usually starts in areas of skin exposed to the sun. (oncolink.org)
  • This PDQ cancer information summary has current information about the treatment of Merkel cell carcinoma. (oncolink.org)
  • Merkel cell carcinoma is a very rare disease in which malignant (cancer) cells form in the skin. (oncolink.org)
  • Loss of heterozygosity has been observed in chromosome 3 (3p21, which is also seen in small cell cancer of the lung), as well as in chromosomal arm 10q and chromosome 13. (medscape.com)
  • Our Merkel Cell Treatment Program is comprised of world-renowned specialists for a rare type of skin cancer. (massgeneral.org)
  • An experimental combination of three different therapies for the rare skin cancer known as Merkel cell carcinoma helps three out of four patients for complete remission following the treatment. (medindia.net)
  • Merkel Cell Carcinoma caused by Merkel cell polyomavirus is a rare type of skin cancer which can now be treated with a triple drug immu notherapy. (medindia.net)
  • Today marks the approval of the first-ever treatment indicated for Merkel cell carcinoma in Japan, making this a significant milestone for patients living with this devastating type of skin cancer," said Luciano Rossetti, M.D., Executive Vice President, Global Head of Research & Development at the biopharma business of Merck KGaA, Darmstadt, Germany, which operates as EMD Serono in the US and Canada. (pfizer.com)
  • MCC is a rare and aggressive disease in which cancer cells form in the top layer of the skin, close to nerve endings. (pfizer.com)
  • Merkel cell carcinoma is a rare and a highly aggressive primary skin cancer that grows rapidly and is hard to treat when it spreads beyond the skin. (medindia.net)
  • FDA has granted priority review designation for Merck's request for a supplemental biologics license application for pembrolizumab to treat Merkel cell carcinoma, a rare skin cancer. (ajmc.com)
  • and certain patients with primary mediastinal large B-cell lymphoma, urothelial carcinoma, gastric cancer, cervical cancer. (ajmc.com)
  • Merkel cell carcinoma is an uncommon but very dangerous type of skin cancer . (emedicinehealth.com)
  • Text Reference: "Merkel Cell Carcinoma: An Uncommon But Often Lethal Cancer. (emedicinehealth.com)
  • Merkel cell carcinoma is a rare, lethal cancer histopathologically composed of cells showing similarity with mechanoreceptor Merkel cells. (bioportfolio.com)
  • European regulators granted market approval for Merck KGaA and Pfizer's immuno-oncology drug Bavencio to treat a rare and aggressive type of skin cancer called Merkel cell carcinoma. (pharmalive.com)
  • Merkel cell carcinoma is a rare type of cancer, with about 2,000 new cases diagnosed each year in the United States, but incidence has been increasing slowly over the past decade," said Howard L. Kaufman, MD , a surgical oncologist at Rutgers Cancer Institute of New Jersey in New Brunswick, New Jersey. (aacr.org)
  • Merkel cell carcinoma (MCC) is a rare, aggressive form of skin cancer with a high risk for returning (recurring) and spreading (metastasizing), often within two to three years after initial diagnosis. (skincancer.org)
  • When Luis found out he had Merkel cell carcinoma, a rare form of skin cancer, he was determined to beat it. (skincancer.org)
  • At Dana-Farber/Brigham and Women's Cancer Center (DF/BWCC), we treat patients from across the country and around the world for the treatment of Merkel cell carcinoma. (dana-farber.org)
  • Merkel cell carcinoma of the skin is a rare form of skin cancer . (dermnetnz.org)
  • A specific Merkel cell carcinoma staging system is published by the American Joint Committee on Cancer. (dermnetnz.org)
  • We established a cell culture model for Merkel cell polyomavirus infection, which will help us find how this DNA virus causes cancer," You said. (biologynews.net)
  • This suggests that Merkel cell carcinoma risk factors such as ultraviolet radiation and aging, which are known to stimulate the expression of these metalloproteinase enzymes, may promote viral infection and thus drive the development of cancer. (biologynews.net)
  • This work built on the system for production of both Merkel cell polyomavirus pseudovirus and recombinant virions established in the laboratory of Christopher B. Buck, PhD at the National Cancer Institute. (biologynews.net)
  • A research team led by Paul Nghiem, M.D., Ph.D., at the Fred Hutchinson Cancer Research Center conducted this first-of-its-kind study of Merkel cell carcinoma responses to an anti-PD1 drug. (news-medical.net)
  • The study included 26 subjects treated with an anti-PD1inhibitor drug, which helps T-cells combat cancer cells. (news-medical.net)
  • Cancer cells from the tumor would likely follow this path. (skincancer.org)
  • Identifying where cancer cells may have spread. (skincancer.org)
  • Revealing cancer cells that are not visible and cannot be detected through physical examination or imaging. (skincancer.org)
  • Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma. (sigmaaldrich.com)
  • When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. (sigmaaldrich.com)
  • One kind of immunotherapy uses monoclonal antibodies- drugs designed to bind to specific targets in the body that can cause an immune response that destroys cancer cells. (federallabs.org)
  • They found that adding the checkpoint inhibitor made a significant difference and kept the cancer at bay in three out of four patients with metastatic Merkel cell carcinoma. (cancernetwork.com)
  • We've got the tumor and we upregulate [a certain protein] to throw some kindling on, and then we put the T cells in to light the match, and then we put the checkpoint blocker in to fan the flames," said Paulson, who is an oncology fellow at Fred Hutchinson Cancer Center. (cancernetwork.com)
  • Today marks the approval of the first-ever treatment indicated for Merkel cell carcinoma in Japan, making this a significant milestone for patients living with a devastating type of skin cancer," said Luciano Rossetti, M.D., Executive Vice President, Global Head of Research & Development at the biopharma business of Merck. (presseportal.ch)
  • A recent report regarding pembrolizumab (Keytruda) for advanced Merkel cell carcinoma ushered in a more optimistic era in the treatment of this rare but often lethal skin cancer. (ascopost.com)
  • Merkel Cell Carcinoma Skin Cancer Rates Rising in U.S. (allure.com)
  • Merkel cell carcinoma is a rare type of skin cancer that may initially resemble a harmless mole, but in fact is very aggressive, can spread throughout the body, and is potentially fatal,' Joshua Zeichner , director of cosmetic and clinical research in dermatology at Mount Sinai in New York City, tells Allure . (allure.com)
  • Currently, there are 2,488 cases of Merkel cell cancer diagnosed in the United States each year, but researchers at the University of Washington predict that will jump to 3,284 cases by 2025. (allure.com)
  • Merkel cell cancer usually shows up as a rapidly growing, often symmetrical, red or purple, painless nodule or bump,' says Paulson. (allure.com)
  • Merkel cell carcinoma (MCC) is an aggressive neuroendocrine cancer of the skin prone with a high risk of metastasis and whose incidence has tripled over the last 20 years. (pharmiweb.com)
  • Merkel cell carcinoma is a rare, rapidly spreading skin cancer that tends to affect older white people. (merckmanuals.com)
  • In most people, the cancer has already spread by the time the diagnosis has been made, so the prognosis of Merkel cell carcinoma is poor. (merckmanuals.com)
  • Treatment of Merkel cell carcinoma is determined by cancer staging and typically includes wide local excision, often followed by radiation therapy, lymph node dissection, or both. (merckmanuals.com)
  • Agents that stimulate T cell activity, block Treg function or inhibit PD-1 signaling may be effective in the treatment of this highly malignant skin cancer. (harvard.edu)
  • The FDA's approval was based on Cancer Immunotherapy Trials Network protocol 9 (CITN-09), also known as KEYNOTE-017 , a multicenter, nonrandomized, open-label trial that enrolled 50 patients with recurrent locally advanced or metastatic Merkel cell carcinoma who had not received prior systemic therapy for advanced disease. (ascopost.com)
  • This is a Phase 1b/2, multiple-dose study designed to describe safety and efficacy, and to assess PK and immunogenicity of XmAb18087 monotherapy and in combination with pembrolizumab in subjects with metastatic Merkel cell (MCC) or locoregional MCC that has recurred after locoregional therapy with surgery and/or radiation therapy, and XmAb18087 monotherapy in subjects with extensive-stage small cell lung cancer (SCLC) that has progressed after standard therapies. (centerwatch.com)
  • The IL-15/Fc superagonist N-803, developed by NantCell, Inc., an affiliate company, has been shown to synergistically activate NK and T cells and enhance cancer cell killing in both single agent and combination therapy. (biospace.com)
  • MCC is a rare and aggressive skin cancer that arises from uncontrolled growth of cells in the skin. (biospace.com)
  • Merkel cell carcinoma is a rare and aggressive type of skin cancer with a high risk of recurrence and metastasis. (medgadget.com)
  • Merkel's cell cancer is a neuroendocrine tumor of the skin. (oncolink.org)
  • Merkel's cell cancer grows rapidly and often has already spread before detection. (oncolink.org)
  • Join us for our March LIVE webinars on metastatic colorectal cancer & hepatocellular carcinoma. (onclive.com)
  • Metastatic Merkel Cell carcinoma (MCC) is a highly unusual and aggressive skin cancer that presents as a small, pink to violet skin lesion and metastasizes early in its growth. (scirp.org)
  • Small cell lung cancer, another neuroendocrine tumor, is associated with paraneoplastic syndromes (PNS) in up to 20% of cases, notably the syndrome of inappropriate antidiuretic hormone (SIADH) and Lambert-Eaton myasthenic syndrome. (aad.org)
  • Merkel cell carcinoma is a particularly aggressive form of skin cancer with very poor outcomes, especially for those with metastatic disease," said Dirk Schadendorf, MD, Director of Dermatology, University Hospital Essen, Germany. (perssupport.nl)
  • The Finnish Cancer Registry reported significantly increased risks for basal cell carcinoma of the skin and chronic lymphocytic leukaemia after the diagnosis of MCC ( Koljonen et al , 2010 ). (pubmedcentralcanada.ca)
  • Cancer is caused by changes ( mutations ) in the DNA inside of cells . (nih.gov)
  • 1 Merkel cell carcinoma was first noted in 1972 and termed trabecular carcinoma of the skin , and it accounts for less than 1% of all nonmelanoma skin cancer. (mdedge.com)
  • Merkel cell carcinoma (MCC) is a rare neuroendocrine skin cancer that is frequently lethal ( 1 ). (aacrjournals.org)
  • Merkel cell carcinoma (MCC) is an aggressive cancer with frequent metastasis and death with few effective therapies. (aacrjournals.org)
  • Merkel cell carcinoma is an aggressive form of skin cancer associated with very poor outcomes, particularly once the disease has metastasized," says Dr. John Walker, Oncologist, Cross Cancer Institute. (pfizer.ca)
  • ABSTRACT Merkel cell polyomavirus is the primary etiological agent of the aggressive skin cancer Merkel cell carcinoma (MCC). (harvard.edu)
  • His work has also extended to serving on expert panels such as those dedicated to merkel cell cancer and guidelines of care. (wikipedia.org)
  • On December 19, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA®, Merck & Co. Inc.) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). (fda.gov)
  • The FDA has granted an accelerated approval to pembrolizumab (Keytruda) for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). (onclive.com)
  • So it was a pivotal moment for patients with metastatic Merkel cell carcinoma when FDA approved the first treatment for this rare but life-threatening disease. (fda.gov)
  • AN: I'm really excited to be here at the D.I.S.C.O. today since we're going to discuss a landmark approval for patients with metastatic Merkel Cell Carcinoma. (fda.gov)
  • This supportive study collected information on the outcomes of patients with metastatic Merkel Cell carcinoma treated in the first line and beyond. (fda.gov)
  • Future Science Group (FSG) announced the publication of an article in Future Oncology that has demonstrated in patients with metastatic Merkel cell carcinoma (mMCC). (medindia.net)
  • New and emerging treatments for metastatic Merkel cell carcinoma. (cancer.org)
  • SB: It is approved for the treatment of adults and pediatric patients 12 years and older who have metastatic Merkel cell carcinoma. (fda.gov)
  • A retrospective, observational study-a chart review of electronic medical records obtained in community and academic centers-was submitted to describe the natural history of metastatic Merkel Cell tumor. (fda.gov)
  • Treatment options for metastatic Merkel cell carcinoma are limited. (nice.org.uk)
  • This is an open-label, non-randomized, phase 2 study to assess the feasibility of using cabozantinib in recurrent/metastatic Merkel Cell Carcinoma patients that progressed after platinum-based therapy. (clinicaltrials.gov)
  • The purpose of this study is to assess the clinical activity and safety of INCMGA00012 in participants with metastatic merkel cell carcinoma (MCC). (bioportfolio.com)
  • No correlation between the methylation status of the analyzed RASSFs or between RASSF methylation and MCC characteristics (primary versus metastatic, Merkel cell polyoma virus infection, age, sex) was found. (mdpi.com)
  • Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). (sciencemag.org)
  • Metastatic Merkel cell carcinoma is a devastating disease and patients in Europe currently have very few treatment options," said Chris Boshoff, M.D., PhD, Senior Vice President and Head of Immuno-Oncology, Early Development, Translational Oncology, Pfizer Global Product Development. (bionity.com)
  • In particular MCC metastasis can mimic metastasis from other small cell neoplasms, that is, for example lung carcinoma [ 3 , 11 ]. (hindawi.com)
  • There is thus a 20- to 30-fold higher chance that the average Merkel cell carcinoma has metastasized to the nodes, and a 2- or 3-fold higher chance of distant metastasis and death. (ascopost.com)
  • A unique case of Merkel cell carcinoma with ovarian metastasis [published online December 1, 2014]. (mdedge.com)
  • There are several different therapies that might be recommended to treat recurrent Merkel cell carcinoma. (moffitt.org)
  • MCC is similar to Merkel cells in its histological appearance (see below: Diagnosis) and shares many immunohistochemical markers with Merkel cells, including epidermal marker cytokeratin 20 and neuroendocrine markers synaptophysin and chromogranin A. Furthermore, the ion channel Piezo2 and transcription factor Atoh1, both specific to Merkel cells, are also expressed by MCC. (wikipedia.org)
  • Correct diagnosis is essential for appropriate prognosis and management, as later recurrence or metastases may only show the Merkel-cell component. (bioportfolio.com)
  • Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy affecting the skin, for which timely diagnosis and aggressive treatment are essential. (bioportfolio.com)
  • The Global Merkel Cell Carcinoma Market Is Segmented on the basis of diagnosis, treatment, and end users. (medgadget.com)
  • Focus on Merkel cell carcinoma: diagnosis and staging [published online January 30, 2015]. (mdedge.com)
  • Cardoso JC, Teixeira V, Tchernev G, Wollina U. Merkel cell carcinoma: a review and update on aetiopathogenesis, diagnosis and treatment approaches. (springermedizin.at)
  • however, recent research suggests that it is unlikely that MCC originates directly from normal Merkel cells. (skincancer.org)
  • Normal Merkel cells in the skin: In this illustration of a cross-section of the skin, normal Merkel cells are shown in red and connect to nerves shown in yellow. (skincancer.org)
  • Merkel cell carcinoma arises from uncontrolled growth of cells in the skin that share some characteristics with normal Merkel cells. (merckmanuals.com)
  • Concomitant Merkel cell carcinoma and basal cell carcinoma presenting as a solitary nodule. (harvard.edu)
  • Because of the differences in physiology and prognosis between MCV+ and MCV- MCC (see below), however, some have suggested that these two subtypes of MCC may actually derive from different progenitor cells. (wikipedia.org)
  • A new data set is informative as to stage-specific survival and can be accessed online at www.merkelcell.org/prognosis/index.php . (ascopost.com)
  • Additionally, they have not been shown to support Merkel-cell polyoma virus infection, which is believed to drive oncogenesis in approximately 80% of MCC. (wikipedia.org)
  • The pathogenesis of MCC has recently been attributed to the Merkel Cell polyoma virus. (scirp.org)
  • Biological therapies, such as cellular adoptive immunotherapy, may stimulate the immune system in different ways and stop tumor cells from growing. (clinicaltrials.gov)
  • after treatment, tumor cells were absent and immune cells were present, suggesting that the treatment had activated an immune response that eliminated the tumor. (news-medical.net)
  • PD-L1 expressed on tumor cells and tumor-infiltrating immune cells can contribute to inhibition of antitumor immune response in the tumor microenvironment. (ascopost.com)
  • In this photo, the tumor cells are stained green and the blood vessels stained red. (cancer.gov)
  • This inactivates the T cells and allows tumor cells to avoid immune attack. (cancer.gov)
  • People with weakened immune systems - including those with HIV infection, those taking drugs that suppress the immune response or those with chronic leukemias - are more likely to develop Merkel cell carcinoma. (mayoclinic.org)
  • 4],[6] Risk factors for MCC include sun exposure and infection with Merkel cell polyomavirus. (pfizer.com)
  • It is "often associated with Merkel cell polyomavirus infection" and "exposure to UV light, advanced age, and immunosuppression elevate risk," noted Kaufman. (nursingcenter.com)
  • Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in immune-compromised individuals. (biologynews.net)
  • This study, from the Perelman School of Medicine at the University of Pennsylvania, establishes a new way to investigate this type of oncogenic viral infection and identifies a potential therapeutic agent against Merkel cell polyomavirus infection. (biologynews.net)
  • catenin proteins stimulate Merkel cell polyomavirus infection. (biologynews.net)
  • Low doses of trametinib wiped out viral infection in the cell culture model developed by first author Wei Liu, PhD, a senior postdoctoral fellow in the You laboratory. (biologynews.net)
  • Building on this novel cell culture model for Merkel cell polyomavirus infection, we would like to establish an animal model to elucidate the mechanisms by which Merkel cell polyomavirus infection leads to the highly aggressive Merkel cell carcinoma," Liu said. (biologynews.net)
  • Merkel cell polyomavirus infection and Merkel cell carcinoma. (aad.org)
  • Gene expression differences predict treatment outcome of Merkel cell carcinoma patients. (springermedizin.at)
  • Merkel cell carcinoma of the head and neck is a rare and aggressive malignant tumour. (hindawi.com)
  • M1 macrophages activate the immune response against malignant or infected cells, whereas M2 macrophages are anti-inflammatory and downregulate M1-mediated immune response, and promote angiogenesis and tissue remodeling ( 18 ). (aacrjournals.org)
  • In 1972, Toker described an unknown, trabecular carcinoma of the skin in five caucasian patients [ 3 ]. (hindawi.com)
  • Merkel cell carcinoma (MCC) was originally described by Toker in 1972 as trabecular carcinoma of the skin. (oncolink.org)
  • Toker C. Trabecular carcinoma of the skin. (springermedizin.at)
  • Being exposed to ultraviolet light, such as the light that comes from the sun or from tanning beds, increases your risk of Merkel cell carcinoma. (mayoclinic.org)
  • Your risk of Merkel cell carcinoma increases as you age. (mayoclinic.org)
  • Sun exposure and having a weak immune system can affect the risk of Merkel cell carcinoma. (oncolink.org)
  • New findings show how immune system marker can help and often outperform imaging studies for recurrence of Merkel cell carcinoma. (medindia.net)
  • A recurrence of Merkel cell carcinoma on the forehead. (skincancer.org)
  • Houben R, Adam C, Baeurle A, Hesbacher S, Grimm J, Angermeyer S. An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. (medscape.com)
  • B ) Western blot with Ab3 or CM2B4 of cell lysates prepared from MCC cell lines showing a predominant signal for truncated large T antigen between 36 and 50 kDa. (jci.org)
  • Knockdown of MCV large T antigen in MCV-positive MCC cell lines decreased survivin mRNA and protein expression. (sciencemag.org)
  • Exogenously expressed MCV large T antigen increased survivin protein expression in non-MCC primary cells. (sciencemag.org)
  • UV rays damage the DNA inside skin cells. (cancer.org)
  • Merkel cells, found in the top layer of the skin, are touch receptors. (healthcentral.com)
  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine tumor of the skin with a mortality rate of approximately 25% (Peloschek et al. (hindawi.com)
  • Merkel cell carcinoma is a rare and highly aggressive neuroendocrine tumor of the skin. (hindawi.com)
  • In fact, patients presenting with unclear new skin lesions should undergo clinical examination, and lesion still highly suspicious for Merkel cell carcinoma should be excised with clear and wide margins. (hindawi.com)
  • If Merkel cell carcinoma does come back, unusual skin changes can often be detected in their earliest stages during follow-up assessments. (moffitt.org)
  • The other major risk factor is exposure to ultraviolet rays of the sun, which can damage cells found in the top layers of the skin. (cancer.gov)
  • The first sign of Merkel cell carcinoma is usually a fast-growing, painless nodule (tumor) on your skin. (mayoclinic.org)
  • Merkel cells are found at the base of the outermost layer of your skin (epidermis). (mayoclinic.org)
  • Merkel cells are connected to the nerve endings in the skin that are responsible for the sense of touch. (mayoclinic.org)
  • The virus (Merkel cell polyomavirus) lives on the skin and doesn't cause any signs or symptoms. (mayoclinic.org)
  • The majority of Merkel cell carcinomas appear on skin surfaces frequently exposed to sun. (mayoclinic.org)
  • Merkel cell carcinoma usually arises in people who have light-colored skin. (mayoclinic.org)
  • Even with treatment, Merkel cell carcinoma commonly spreads (metastasizes) beyond the skin. (mayoclinic.org)
  • In most cases, Merkel cell carcinoma develops in areas of skin that are frequently exposed to UV rays from natural sources (the sun) or artificial sources (tanning beds and psoriasis treatments that incorporate the use of UV light). (moffitt.org)
  • Merkel cell carcinoma usually appears as a single painless lump on sun-exposed skin. (oncolink.org)
  • Tests and procedures that examine the skin are used to diagnose Merkel cell carcinoma. (oncolink.org)
  • Merkel cell carcinoma starts most often in areas of skin exposed to the sun, especially the head and neck, as well as the arms, legs, and trunk . (oncolink.org)
  • This and other changes in the skin may be caused by Merkel cell carcinoma or by other conditions . (oncolink.org)
  • Sastre-Garau X, Peter M, Avril MF, Laude H, Couturier J, Rozenberg F. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. (medscape.com)
  • Merkel cell carcinomas look like red, blue, or flesh-colored lumps that appear on sun-exposed areas of the skin. (emedicinehealth.com)
  • The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (bioportfolio.com)
  • What is Merkel cell carcinoma of the skin? (dermnetnz.org)
  • Merkel cell carcinoma was previously believed to arise from Merkel cells , which are pressure receptors in the skin. (dermnetnz.org)
  • Researchers have now identified a type of skin cell as the target of the virus in humans. (biologynews.net)
  • This could allow viruses to enter the cells of the dermis skin layer, surmise the researchers. (biologynews.net)
  • The Merkel cell polyomavirus is an abundant virus frequently found on healthy human skin. (biologynews.net)
  • Although the exact function of Merkel cells, found in the lower part of the skin epidermis, is unknown, they are thought to be nerve-associated cells involved in light touch sensation. (biologynews.net)
  • The malignancy is believed to originate from neuroendocrine cells of the skin. (mdpi.com)
  • These are found in the dermis of the skin as nerve-associated neuroendocrine cells and in the basal layer of the epidermis of the skin (Merkel cells) [ 3 ]. (mdpi.com)
  • Merkel cells are normal cells in the epidermis (the outer layer of the skin). (merckmanuals.com)
  • Although Merkel cell carcinoma can affect any part of the skin, it is most common on skin that has been chronically exposed to sunlight (for example, the face and arms). (merckmanuals.com)
  • Although Merkel cell carcinoma can affect any part of the skin, it is most common on sun-exposed areas (eg, face, upper extremities). (merckmanuals.com)
  • Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus. (pubmedcentralcanada.ca)
  • Factors associated with developing MCC include increasing age, fair skin, a history of extensive sun exposure, chronic immune suppression, and the Merkel cell polyomavirus. (nih.gov)
  • Long-term sun exposure or a weak immune system may increase your risk of developing Merkel cell carcinoma. (mayoclinic.org)
  • It strengthens the body's own anti-tumor immune response, influences the tumor and tumor microenvironment, making the tumor more visible to the immune system and facilitating the infiltration of immune cells into the tumor. (pharmiweb.com)
  • Merkel call carcinoma also affects younger people whose immune system is weakened. (merckmanuals.com)
  • Upfront immunotherapy with pembrolizumab ( Keytruda , Merck & Co) in patients with advanced Merkel cell carcinoma (aMCC) shows an improved overall survival and response rate when compared with historical controls, and has a generally manageable safety profile, according to new findings. (medscape.com)
  • SEER = Surveillance, Epidemiology, and End Results Program.aAlbores-Saavedra J et al: Merkel cell carcinoma demographics, morphology, and survival based on 3,870 cases: A population-based study. (oncolink.org)
  • To determine progression-free survival and overall survival of patients receiving cabozantinib for Merkel Cell Carcinoma. (clinicaltrials.gov)
  • Durable tumor regression and overall survival (OS) in patients with advanced Merkel cell carcinoma (aMCC) receiving pembrolizumab as first-line therapy. (onclive.com)
  • The objective of this study was to evaluate the epidemiological profile of patients with Merkel cell carcinoma, the clinical characteristics of the tumor, time between manifestation of signs and symptoms and initiation of treatment, survival and causes of death. (scielo.br)
  • Given the ability of pembrolizumab to extend survival for some patients with advanced Merkel cell carcinoma, what's the overall outlook in this malignancy? (ascopost.com)
  • You mentioned that the presence of CD8 T cells confers virtually a 100% probability of survival. (ascopost.com)
  • This required an intact retinoblastoma protein-targeting domain that activated survivin gene transcription as well as expression of other G 1 -S-phase proteins including E2F1 and cyclin E. Survivin expression is critical to the survival of MCV-positive MCC cells. (sciencemag.org)
  • HealthDay News) -- For patients with Merkel cell carcinoma (MCC), predictors of recurrence and survival have been identified which may help to inform diagnostic and therapeutic management, according to a study published online May 7 in JAMA Dermatology . (oncologynurseadvisor.com)
  • High intratumoral numbers of CD3 + , CD8 + , or FoxP3 + cells, and high CD8 + /CD4 + or FoxP3 + /CD4 + ratios, were significantly associated with favorable overall survival. (aacrjournals.org)
  • High intratumoral numbers of CD3 + , CD8 + , and FoxP3 + lymphocytes were each significantly associated with favorable overall survival of patients diagnosed with MCC, and a high tumor CD3 + cell count had independent influence on survival in a Cox multivariable model. (aacrjournals.org)
  • No histopathologic variable associated with overall survival (OS) or disease-specific survival (DSS), whereas higher CD3 + ( P = 0.004) and CD8 + ( P = 0.037) T-cell density at the tumor periphery associated with improved OS. (aacrjournals.org)
  • Chronic mTOR activation promotes cell survival in Merkel cell carcinoma. (springermedizin.at)
  • ABT-263 induced Bax-dependent apoptosis with rapid cleavage of caspase-3 and PARP, regardless of Bcl-2 family profile or the presence of Merkel cell polyomavirus. (nih.gov)
  • Responses were observed irrespective of PD-L1 tumor cell expression or presence of Merkel cell polyomavirus. (ascopost.com)
  • Earlier this year, another phase II trial showed that pembrolizumab (Keytruda), which targets PD-1, is effective in Merkel cell carcinoma. (cancernetwork.com)
  • No drugs have been approved by the Food and Drug Administration for the treatment of Merkel cell carcinoma. (cancer.gov)
  • Expert-reviewed information summary about the treatment of Merkel cell carcinoma. (oncolink.org)
  • What is the treatment of Merkel cell carcinoma? (dermnetnz.org)
  • A new triple therapy approach using a checkpoint inhibitor and T-cell therapy is showing considerable promise in the treatment of Merkel cell carcinoma. (cancernetwork.com)
  • The study findings make early detection and treatment of Merkel cell carcinoma a top priority. (allure.com)
  • S. Donepudi, R. C. Deconti and W. E. Samlowski, "Recent Advances in the Understanding of the Genetics, Etiology and Treatment of Merkel Cell Carcinoma," Seminars in Oncology, Vol. 39, No. 2, 2012, pp. 163-172. (scirp.org)
  • This growing incidence rate has given a significant input for a growing interest in disease management of patients with Merkel cell carcinoma [ 15 , 16 ]. (hindawi.com)
  • Merkel cells are highly specialized cells that act as pressure receptors in the epidermis. (wikipedia.org)
  • Merkel cells are in the layer of basal cells at the deepest part of the epidermis and are connected to nerves. (oncolink.org)
  • An autoimmune-based, paraneoplastic neurologic syndrome following checkpoint inhibition and concurrent radiotherapy for merkel cell carcinoma: case report. (bioportfolio.com)
  • An unusual case of diffuse Merkel cell carcinoma successfully treated with low dose radiotherapy [published online May 14, 2015]. (mdedge.com)
  • Sadeghi R, Adinehpoor Z, Maleki M, Fallahi B, Giovanella L, Treglia G. Prognostic significance of sentinel lymph node mapping in Merkel cell carcinoma: systematic review and meta-analysis of prognostic studies. (springermedizin.at)
  • Becker JC, Houben R, Ugurel S, Trefzer U, Pfohler C, Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. (medscape.com)
  • MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. (nih.gov)
  • Fred Hutch immunotherapy researcher Dr. Kelly Paulson used a combination of T-cell therapy, immunotherapy drug and radiation and tested its effect on patients with Merkel cell carcinoma. (medindia.net)
  • KEYNOTE-017 represents the longest observation to date of patients with advanced Merkel cell carcinoma receiving anti-PD-1 therapy in the first-line setting, and demonstrated durable tumor control in these patients. (ajmc.com)
  • In July 2017, the treatment received Breakthrough Therapy designation for Merkel cell carcinoma. (ajmc.com)
  • This research study is studying a targeted therapy as a possible treatment for merkel cell carcinoma. (bioportfolio.com)
  • The primary objectives of this study are to assess 1) the safety and 2) efficacy of combining Anti-PD-1/PD-L1 blockade with palliative radiation therapy in patients with Stage IV Merkel Ce. (bioportfolio.com)
  • Using the latest diagnostic and treatment modalities, our Merkel cell carcinoma experts develop individualized treatment plans for newly diagnosed patients, and we closely monitor patients who have completed their therapy. (dana-farber.org)
  • This small study of four patients built off a previous study that tested a double combination of just T-cell therapy and radiation or interferon in four patients. (cancernetwork.com)
  • The researchers found that the transferred T cells persisted and peak frequencies correlated with rate of tumor regression in patients receiving triple therapy. (cancernetwork.com)
  • NantKwest's phase II immunotherapy trial builds upon the company's earlier phase II single-combination study using its proprietary, off-the-shelf aNK TM natural killer cell therapy and IL-15/Fc superagonist (N-803), which produced an objective responses in 3 of 7 patients. (biospace.com)
  • Commenting on the initiation of this novel triple combination trial in MCC, Patrick Soon-Shiong, MD, Chairman and CEO of NantKwest said, "Even in a heavily pretreated patient population, including patients who have failed checkpoint inhibitor therapy, we were encouraged to see our combination of aNK cell and N-803 therapy exhibit preliminary clinically meaningful antitumor activity, including objective response in this resistant setting. (biospace.com)
  • NantKwest's haNK cell therapy platform is a natural killer cell therapy that was developed to optimize the key role of natural killer cells in mediating innate immunity, enhancing adaptive immune responses, and, specifically in the case of haNK, improve anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC). (biospace.com)
  • Systemic Therapy for Merkel Cell Carcinoma: What's on the Horizon? (mdpi.com)
  • Merkel cell carcinoma: epidemiology, target, and therapy. (andhranews.net)
  • T-cell receptor sequencing (TCRseq) was performed in a subset of MCCs. (aacrjournals.org)