Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and an epidermal cell.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
A species of POLYOMAVIRUS suspected to be the cause of most cases of MERKEL CELL CARCINOMA, a rare but highly lethal form of skin cancer.
Infections with POLYOMAVIRUS, which are often cultured from the urine of kidney transplant patients. Excretion of BK VIRUS is associated with ureteral strictures and CYSTITIS, and that of JC VIRUS with progressive multifocal leukoencephalopathy (LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL).
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Tumors or cancer of the SKIN.
A genus of potentially oncogenic viruses of the family POLYOMAVIRIDAE. These viruses are normally present in their natural hosts as latent infections. The virus is oncogenic in hosts different from the species of origin.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
MUCOUS MEMBRANE extending from floor of mouth to the under-surface of the tongue.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Tumors or cancer of the LIVER.
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Deoxyribonucleic acid that makes up the genetic material of viruses.
A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A cell line derived from cultured tumor cells.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A type II keratin found associated with KERATIN-18 in simple, or predominately single layered, internal epithelia.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Tumors or cancer of the LUNG.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
A MARVEL domain-containing protein found in the presynaptic vesicles of NEURONS and NEUROENDOCRINE CELLS. It is commonly used as an immunocytochemical marker for neuroendocrine differentiation.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS.
Tumors or cancer of the LIP.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
An acidic protein found in the NEUROENDOCRINE SYSTEM that functions as a molecular chaperone for PROPROTEIN CONVERTASE 2.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Tumors of cancer of the EYELIDS.
The part of the face that is below the eye and to the side of the nose and mouth.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the NASOPHARYNX.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The specificity of a virus for infecting a particular type of cell or tissue.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Merkel cell carcinoma and melanoma: etiological similarities and differences. (1/218)

Merkel cell carcinoma (MCC) of the skin and cutaneous malignant melanoma can now be compared epidemiologically through the use of population-based data not previously available for MCC. The results may provide new clues to etiology. In this study, United States data covered by the Surveillance, Epidemiology, and End Results (SEER) Program were from nine areas of the United States (approximately 10% of the population). In 1986-1994, 425 cases of MCC were registered. The annual age-adjusted incidence per 100,000 of MCC was 0.23 for whites and 0.01 for blacks; among whites, the ratio of melanoma to MCC was approximately 65 to 1. Only 5% of MCC occurred before age 50, unlike the lifelong risk of nodular and superficial spreading melanoma. Regional incidence rates of both cancers increased similarly with increasing sun exposure as measured by the UVB solar index. The most sun-exposed anatomical site, the face, was the location of 36% of MCC but only 14% of melanoma. Both cancers increased in frequency and aggressiveness after immunosuppression and organ transplantation (36 cases from the Cincinnati Transplant Tumor registry and 12 from published case reports) and after B-cell neoplasia (5 cases in this study; 13 from case series in the literature). The SEER data contained reports of six patients with both types of cancer; 5 melanomas before the diagnosis of MCC and 1 after diagnosis. MCC and melanoma are similarly related to sun exposure and immunosuppression, but they differ markedly from one another in their distributions by age, race, and anatomical site, especially the face.  (+info)

Mutation analysis of P73 and TP53 in Merkel cell carcinoma. (2/218)

The p73 gene has been mapped to 1p36.33, a region which is frequently deleted in a wide variety of neoplasms including tumours of neuroectodermal origin. The p73 protein shows structural and functional homology to p53. For these reasons, p73 was considered as a positional and functional candidate tumour suppressor gene. Thus far, mutation analysis has provided no evidence for involvement of p73 in oligodendrogliomas, lung carcinoma, oesophageal carcinoma, prostatic carcinoma and hepatocellular carcinoma. In neuroblastoma, two mutations have been observed in a series of 140 tumours. In view of the occurrence of 1p deletions in Merkel cell carcinoma (MCC) and the location of p73 we decided to search for mutations in the p73 gene in five MCC cell lines and ten MCC tumours to test potential tumour suppressor function for this gene in MCC. In view of the possible complementary functions of p73 and TP53 we also examined the status of the TP53 gene. Sequence analysis of the entire coding region of the p73 gene revealed previously reported polymorphisms in four MCCs. In one MCC tumour, a mis-sense mutation located in the NH2-terminal transactivation region of the p73 gene was found. These results show that p73, analogous to neuroblastoma, is infrequently mutated in MCC. This is also the first report in which the role of TP53 in MCC has been investigated by sequencing the entire coding region of TP53. TP53 mis-sense mutations and one non-sense mutation were detected in three of 15 examined MCCs, suggesting that TP53 mutations may play a role in the pathogenesis or progression of a subset of MCCs. Moreover, typical UVB induced C to T mutations were found in one MCC cell line thus providing further evidence for sun-exposure in the aetiology of this rare skin cancer.  (+info)

Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. (3/218)

Merkel cell carcinoma was first described in 1972 by Toker and is an aggressive neuroendocrine skin tumor with a high metastatic potential. Merkel cell carcinoma is thought to derive from the neuroendocrine (Merkel) cells of the skin, although in contrast to fetal and especially adult Merkel cells, Merkel cell carcinomas express high levels of the Bcl-2 oncoprotein. Bcl-2 is capable of blocking programmed cell death and has been shown to play an important role in normal cell turnover, tumor biology, and chemoresistance. High Bcl-2 expression leading to prolonged survival of cells may therefore be of importance in the biological and clinical characteristics of Merkel cell carcinoma. In a SCID mouse xenotransplantation model for human Merkel cell carcinoma, we investigated the influence of the bcl-2 antisense oligonucleotide G3139 (Genta) on tumor growth in comparison with control oligonucleotides or cisplatin. Bcl-2 antisense treatment, targeting the first six codons of the bcl-2 mRNA, resulted in either a dramatic reduction of tumor growth or complete remission, whereas reverse sequence and two-base mismatch control oligonucleotides or cisplatin had no significant antitumor effects compared with saline-treated controls. Apoptosis was enhanced 2.4-fold in the bcl-2 antisense treated tumors compared with the saline-treated group, and no other treatment showed a comparable increase in apoptosis. Our findings suggest that bcl-2 antisense treatment may be a novel approach to improve treatment outcome of human Merkel cell carcinoma.  (+info)

Chemotherapy in neuroendocrine/Merkel cell carcinoma of the skin: case series and review of 204 cases. (4/218)

PURPOSE: To study the use of chemotherapy for Merkel cell carcinoma (MCC) of the skin. PATIENTS AND METHODS: Twenty-five cases of MCC were treated at the London Regional Cancer Center between 1987 and 1997. Thirteen cases treated with chemotherapy were reviewed with 191 cases from the literature. RESULTS: At presentation, 24 patients had localized skin lesions (stage I) and one had locoregional involvement (stage II). Among the nine cases with recurrent nodal disease, six had chemotherapy as a component of salvage treatment. They were all free of disease at a median of 19 months (range, 12 to 37 months). In contrast, two patients who had salvage radiotherapy alone died of disease. Overall survival (OS) and disease-free survival (DFS) were 59% and 43%, respectively, at two years. Median OS and DFS were 29 months (range, 1 to 133 months) and 9 months (range, 1 to 133 months), respectively. Nodal disease developed in 12 (50%) of 24 patients with stage I disease, and distant metastases developed in six (25%) of 24. Including those from the literature, there were 204 cases treated with chemotherapy. Cyclophosphamide/doxorubicin (or epirubicin)/vincristine combination +/- prednisone was the most commonly used chemotherapy regimen (47 cases), with an overall response rate of 75.7% (35.1% complete, 35. 1% partial, and 5.4% minor responses). Etoposide/cisplatin (or carboplatin) was the next most commonly used regimen (27 cases), with an overall response rate of 60% (36% complete and 24% partial responses). The difference in response rate was not statistically significant (P =.19). Among the 204 cases, there were seven (3.4%) toxic deaths. CONCLUSION: Chemoradiation for locally recurrent or advanced disease may be an option for patients with a good performance status.  (+info)

Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies. (5/218)

This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in the subcutaneous interstitial space and in tumour tissue (melanoma, malignant fibrous histiocytoma, Merkel cell tumour and osteosarcoma) in patients undergoing regional chemotherapy by Isolated Limb Infusion (ILI). 19 patients undergoing ILI for treatment of various limb malignancies were monitored for intra-operative melphalan concentrations in plasma and, using microdialysis, in subcutaneous and tumour tissues. Peak and mean concentrations of melphalan were significantly higher in plasma than in subcutaneous or tumour microdialysate. There was no significant difference between drug peak and mean concentrations in interstitial and tumour tissue, indicating that there was no preferential uptake of melphalan into the tumours. The time course of melphalan in the microdialysate could be described by a pharmacokinetic model which assumed melphalan distributed from the plasma into the interstitial space. The model also accounted for the vascular dispersion of melphalan in the limb. Tumour response in the whole group to treatment was partial response: 53.8% (n = 7); complete response: 33.3% (n = 5); no response: 6.7% (n = 1). There was a significant association between tumour response and melphalan concentrations measured over time in subcutaneous microdialysate (P< 0.01). No significant relationship existed between the severity of toxic reactions in the limb or peak plasma creatine phosphokinase levels and peak melphalan microdialysate or plasma concentrations. It is concluded that microdialysis is a technique well suited for measuring concentrations of cytotoxic drug during ILI. The possibility of predicting actual concentrations of cytotoxic drug in the limb during ILI using our model opens an opportunity for improved drug dose calculation. The combination of predicting tissue concentrations and monitoring in microdialysate of subcutaneous tissue could help optimise ILI with regard to post-operative limb morbidity and tumour response.  (+info)

Indium-111 octreotide scintigraphy of Merkel cell carcinomas and their metastases. (6/218)

BACKGROUND: Somatostatin receptor scintigraphy (SRS) may be of interest for staging Merkel Cell Carcinoma (MCC). This study was undertaken to evaluate the sensitivity and specificity of SRS and to determine its role compared to conventional investigations. PATIENTS AND METHODS: From 1993 to December 2000, 20 patients (10 females and 10 males, aged from 38 to 88, mean 66 years) were included prospectively. At the time of SRS: 12 patients had been diagnosed as having stage I disease, 6 stage II and 4 stage III. Two patients had two SRS studies during the course of their disease. SRS was performed with Indium-111 pentetreotide (Octreoscan), a radiolabelled somatostatin analogue. Patients were treated according to the clinical stage. A regular follow-up was scheduled every three months. RESULTS: SRS depicted stage I and II MCC tumour sites with an overall sensitivity of 78% (95% confidence interval (CI): 40%-97%) and a specificity of 96% (81%-100%). The histopathological diagnosis was used as the gold standard. Sites visualised by SRS were compared to those detected with conventional modalities and to follow-up data for all stages: SRS visualised four out of five primary tumour sites, six out of eight lymph node sites, no skin metastases (14 sites in 2 patients), two out of three thoracic metastases and zero out of two hepatic metastases. SRS did not influence treatment decision-making in any of the cases. CONCLUSIONS: Although SRS seems highly specific in MCC and could be of help in difficult cases, it cannot be recommended for routine evaluation.  (+info)

Merkel cell carcinoma: a rare cause of hypervascular nasal tumor. (7/218)

Cutaneous neuroendocrine carcinoma, first described in 1972, is an aggressive disease usually occurring in sun-exposed skin. Other sites have been described, however; such tumors occasionally occur within the nasal fossa. A high rate of metastasis (>30%) explains the poor prognosis. Descriptions of the imaging features of these tumors, mainly located in cutaneous region, are rare. We therefore present the imaging features of two cases of Merkel cell carcinoma involving the sinonasal region, suggestive of a hypervascular tumor.  (+info)

Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1. (8/218)

AIM: To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). METHODS: Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. RESULTS: Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. CONCLUSIONS: The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.  (+info)

Merkel cell carcinoma is a rare and aggressive skin malignancy that arises from primary neural cells and has a tendency for local recurrence and regional lymph node metastases. There are only a few cases in the literature reporting metastases of Merkel cell carcinoma to the gastrointestinal tract. We present a 70 year old Caucasian female with distant history of Merkel cell carcinoma who presented with iron-deficiency anemia. Colonoscopy performed later for the evaluation of anemia revealed 1 cm polyp in ascending colon which turned out to be the recurrence of Merkel cell carcinoma. Metastatic Merkel cell carcinoma to the gastrointestinal tract or any other organ should be considered in patients with a history of Merkel cell carcinoma.
1. Lemos B, Nghiem P: Merkel cell carcinoma: more deaths but still no pathway to blame. J Investig Dermatol 2007; 127: 2100-2103. 2. Lemos BD, Storer BR, Iyer JG et al.: Pathologic nodal evaluation improves prognostic accuracy in merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63: 751-761. 3. Toker C: Trabecular carcinoma of the skin. Arch Dermatol 1972; 105: 107-110. 4. Agelli M, Clegg LX: Epidemiology of primary Merkel cell carcinoma in the United States. J Am Acad Dermatol 2003; 49: 832-841. 5. Miller RW, Rabkin CS: Merkel cell carcinoma and melanoma: etiology similarities and differences. Cancer Epidemiol Biomarkers Prev 1999; 8: 485. 6. Feng H, Shuda M, Chang Y et al.: Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008; 319: 1096-1100. 7. Shuda M, Feng H, Kwun HJ et al.: T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA 2008; ...
So these are the characteristics of the 88 patients treated. You can see 25% of the patients were under 65, the vast majority of patients were over the age of 65, consistent with the clinical course of Merkel cell carcinoma. 74% of the patients were men, most had good ECOG performance status. Not surprisingly, 76% of the patients presented with a primary cutaneous Merkel cell carcinoma but some patients their initial presentation was in the lymph node or other sites. Although 59% of the patients had one prior therapy its important to note that 35% of this population had actually failed two or more lines of prior therapy so this is a fairly advanced group. 53% of the patients had evidence of visceral metastases at the study entry and 21% had only lymph node disease at the time they entered.. We also looked at the tumour burden to see if that might be an independent predictor of response, so that data is shown there. We basically measured the sum of the longest diameters of all the index lesions ...
TY - JOUR. T1 - Paraneoplastic and metastatic neurologic complications of Merkel cell carcinoma. AU - Eggers, Scott D.Z.. AU - Salomao, Diva R.. AU - Dinapoli, Robert P.. AU - Vernino, Steven. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2001. Y1 - 2001. N2 - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are rare. We describe a 69-year-old man who presented with Lambert-Eaton myasthenic syndrome and was found to have Merkel cell carcinoma. The paraneoplastic syndrome improved with initial treatment of the malignancy. He subsequently developed a solitary brain metastasis and died of leptomeningeal carcinomatosis.. AB - Merkel cell carcinoma is a rare primary cutaneous neuroendocrine tumor that is locally aggressive and frequently accompanied by distant metastases. Neurologic complications of Merkel cell carcinoma are ...
Merkel cell carcinoma is an aggressive type of skin cancer. Merkel cell carcinoma generally appears in sun-damaged regions of skin of the head, neck, mouth, upper and lower limbs, truck and genital lining. It is more common in elderly males. Merkel cell carcinoma can re-occur after treatment. Want to know about Merkel cell carcinoma? Wondering how it can be treated? Read the following article to know all about the treatment for Merkel cell carcinoma, its causes, symptoms, and complications.
Avelumab showed early positive survival data and lasting responses for patients with pretreated advanced or metastatic Merkel cell carcinoma, according to findings from the phase II JAVELIN Merkel 200 trial presented at the 2016 ASCO Annual Meeting.
Primary: To compare the efficacy, as measured by objective response rate (ORR), provided by nivolumab plus ipilimumab with or without SBRT in subjects with metastatic Merkel cell carcinoma. Secondary: To compare the progression free survival (PFS) of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To compare the overall survival (OS) of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To evaluate the local control of irradiated tumor provided by SBRT in combination with nivolumab and ipilimumab. To assess the overall safety and tolerability of of nivolumab and ipilimumab versus SBRT plus nivolumab and ipilimumab in subjects with metastatic Merkel cell carcinoma. To evaluate whether PD-L1 expression is a predictive biomarker for ORR. To evaluate the Health Related Quality of Life (HRQoL) as assessed by European Organisation for Research and Treatment of Cancer ...
On September 24, 2017, Posted by Birgit Rogell , In Press Releases, With Kommentare deaktiviert für Merck: European Commission Approves Bavencio (avelumab) for Metastatic Merkel Cell Carcinoma ...
TY - JOUR. T1 - Merkel cell carcinoma. T2 - Diagnosis, management, and outcomes. AU - Senchenkov, Alex. AU - Moran, Steven Lawrence. PY - 2013/5. Y1 - 2013/5. N2 - Merkel cell carcinoma is a rare, aggressive cutaneous malignancy with high rates of recurrence, metastases, and mortality. Its nonspecific clinical presentation often delays the diagnosis, and its treatment is still controversial because of the infrequent nature of the tumor. The authors provide an overview of the current literature on epidemiology, cause, pathogenesis, staging, management, and outcomes of this disease. Effective diagnostic and treatment modalities such as wide local excision of the primary tumor, importance of sentinel node biopsy for staging, evidence for the use of adjuvant radiation therapy, and emphasis on a multidisciplinary treatment approach of Merkel cell carcinoma as it pertains to surgical practice are reviewed.. AB - Merkel cell carcinoma is a rare, aggressive cutaneous malignancy with high rates of ...
Merkel cell carcinoma (MCC) is a rare form of skin cancer, often described as the most aggressive cutaneous malignancy. Its high propensity for dermal-lymphatic invasion, local recurrence, and rapid lymphatic and distant metastasis poses a significant treatment challenge to clinicians. Combining its highly aggressive nature with its low incidence, merkel cell carcinoma is a particularly difficult cancer to study. Two major staging criteria exist for Merkel cell carcinoma. The purpose of this study is to validate and compare the Memorial Sloan Kettering Cancer Center (MSKCC) staging criteria with the American Joint Committee on Cancer (AJCC) Tumor, Node, Metastasis (TNM) staging criteria for Merkel cell carcinoma (MCC) utilizing the Surveillance, Epidemiology, and End Results (SEER) database. The role of radiation therapy (RT) is also evaluated. 1556 cases of MCC from the SEER database (1988-2002) were identified and evaluated. Tumor size, lymph node status, and metastases were staged according to the
TY - JOUR. T1 - Expression profiles associated with aggressive behavior in Merkel cell carcinoma. AU - Fernández-Figueras, María Teresa. AU - Puig, Lluís. AU - Musulén, Eva. AU - Gilaberte, Montserrat. AU - Lerma, Enrique. AU - Serrano, Sergio. AU - Ferrándiz, Carlos. AU - Ariza, Aurelio. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm. In spite of its similarities to small cell carcinomas from other locations, Merkel cell carcinoma shows many peculiarities probably related to its epidermal origin and the etiologic role of UV radiation. We have immunohistochemically investigated 43 markers on a tissue microarray in which 31 surgically resected Merkel cell carcinomas were represented. Of these, 15 patients remained free of disease after removal, whereas 16 developed metastases. Immunoreactivity was scored according to staining intensity and the percentage of positive cells. We found ...
Full Title A Phase II Randomized Parallel Two-Arm Clinical Trial Assessing Comprehensive Ablative Radiation Therapy with or without Avelumab in Unresectable and Metastatic Merkel Cell Carcinoma (CARTA) Purpose The purpose of this study is to assess the safety and effectiveness of comprehensive ablative radiation therapy (CART) with or without the immunotherapy drug avelumab in patients with inoperable or metastatic Merkel cell carcinoma (MCC) that has continued to grow despite prior immunotherapy.
Merkel cell carcinoma is a malignant skin tumor with a poor prognosis that primarily affects photoexposed areas of elderly patients. Tumor size is a very strong prognostic factor, with much better outcomes associated with small lesions, measuring less than 1cm. However, such lesions are rarely seen in the clinic in view of the rapid growth of this tumor. We report 2 cases of incipient Merkel cell carcinoma. Both cases of incipient Merkel cell carcinoma measured approximately 5mm in diameter. One tumor was confined to the epidermis and papillary dermis on the nose of a 79-year-old man and the other was located in the deep dermis, almost in the hypodermis, on the buttock of an 82-year-old woman. In both cases, the lesions had appeared weeks earlier. The first tumor seemed to originate in the dermoepidermal junction whereas the second originated almost in the hypodermis. Although the lesions were at a similar disease stage and had a similar size, their different locations within the dermis ...
INTRODUCTION: Merkel cell carcinoma is a rare cutaneous, aggressive tumor. Although it shares many neuroendocrine features with small cell lung carcinoma, it has only occasionally been reported with paraneoplastic neurological syndromes. METHODS: A healthy 67-year-old man developed acute ataxia, vertigo, and nausea. Subsequently he also developed dysarthria, diplopia, xerostomia, fatigability and progressive anorexia. He underwent a full diagnostic workup and was found to have a high titer of voltage-gated calcium channel antibodies in serum and cerebrospinal fluid, neurophysiological findings compatible with Lambert-Eaton myasthenia and neurological signs compatible with cerebellar degeneration. RESULTS: A positron emission tomography study revealed a hypermetabolic lesion in the axilla, subsequently biopsied and consistent with Merkel cell carcinoma. CONCLUSIONS: In most previous reports, neurological symptoms preceded the Merkel cell carcinoma diagnosis, and the primary localization was in lymph
Merkel cell carcinoma commonly present on the extremities and the head. Merkel cell carcinoma is a form of subcutaneous to cutaneous papule or nodule. Merkel cell carcinoma is a red, violet,pink or reddish brown dome shaped lesion.
Find the best merkel cell carcinoma doctors in Navi Mumbai. Get guidance from medical experts to select merkel cell carcinoma specialist in Navi Mumbai from trusted hospitals - credihealth.com
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has been discovered between MCC and either integration of the Merkel cell polyomavirus, which likely drives tumorigenesis, or somatic mutations owing to ultraviolet-induced DNA damage. Both virus-positive and virus-negative MCCs are immunogenic, and inhibition of the programmed cell death protein 1 (PD-1)-programmed cell death 1 ligand 1 (PD-L1) immune checkpoint has proved to be highly effective in treating patients with metastatic MCC; however, not all patients have a durable response to immunotherapy. Despite these rapid advances in the understanding and management of patients with MCC, many basic, translational and clinical research questions remain unanswered. In March 2018, an International Workshop on Merkel Cell Carcinoma Research was held at the US National Cancer Institute, at which academic, government and industry experts met to ...
Given the lack of effective treatment options for patients with metastatic Merkel cell carcinoma whose cancer has recurred after chemotherapy, we are excited to see such a high objective response rate. It is also noteworthy that nearly all of the patients whose cancer initially responded to avelumab exhibited durable responses, with most ongoing for more than a year, continued Kaufman, who is also professor of surgery and medicine at the Rutgers Robert Wood Johnson Medical School. Based on data from this clinical trial, avelumab became the first ever treatment approved by the U.S. Food and Drug Administration for treating patients with this devastating disease.. Kaufman explained that avelumab targets the PD-L1 protein and that the rationale for treating patients with Merkel cell carcinoma with the immunotherapeutic came from studies showing that PD-L1 is found on tumor samples from nearly all patients with this form of cancer.. Kaufman and colleagues enrolled 88 patients with metastatic ...
Merkel cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by a virus (Merkel cell polyomavirus)
Evidence-based recommendations on avelumab (Bavencio) for treating metastatic (secondary) Merkel cell carcinoma (skin cancer) in adults
TY - JOUR. T1 - Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC. AU - Becker, Juergen C.. AU - Stang, Andreas. AU - zur Hausen, Axel. AU - Fischer, Nicole. AU - DeCaprio, James A.. AU - Tothill, Richard W.. AU - Lyngaa, Rikke. AU - Hansen, Ulla Kring. AU - Ritter, Cathrin. AU - Nghiem, Paul. AU - Bichakjian, Christopher K.. AU - Ugurel, Selma. AU - Schrama, David. PY - 2018. Y1 - 2018. N2 - Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations affect comparable signaling pathways such as RB restriction of cell cycle progression or p53 inactivation. Despite its low incidence, MCC recently received much attention based on its exquisite immunogenicity and the resulting major success of immune modulating ...
So you might say this would be a great test, but we dont use it in our patients. Why not? Because it makes no difference therapeutically to the one in five patients who has this favorable CD8 profile. Such patients need to receive the same treatment as other patients, regardless of CD8 infiltration status. Disease can recur in such patients, but if it does, we can cure it. Because the CD8 profile really doesnt change our management, we dont routinely do this test.. Optimal Management. Whats the optimal approach, then, for managing the newly diagnosed Merkel cell carcinoma patient? In most cases of Merkel cell carcinoma (about 80%), Merkel cell polyomavirus is clonally integrated in the tumor cells, and viral oncoproteins drive oncogenesis. There is increasing evidence that these patients do somewhat better than polyomavirus-negative patients. What this means clinically is that the 20% of patients who are virus-negative might need more careful monitoring for recurrence.. Several early ...
Business Wire IndiaMerck and Pfizer today announced that the US Food and Drug Administration (FDA) has granted avelumab*, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, Fast Track designation for the treatment of metastatic Merkel cell carcinoma (MCC), a rare and aggressive type of skin cancer
Merkel cell carcinoma (MCC) is an extremely aggressive epidermis cancer with a growing incidence. This acquiring as well as our observation the fact that PI3K/AKT pathway is certainly activated in nearly all individual MCCs recognizes PI3K/AKT being a potential brand-new therapeutic focus on for MCC sufferers. Launch Merkel cell carcinoma (MCC) is certainly a very intense malignant epidermis tumor. The condition affects older patients. It really is localized in the chronically UV-exposed epidermis preferentially. The relationship between UV light and MCC is most likely because of the immunosuppressive as opposed to the mutagenic aftereffect of UV irradiation. In sufferers with immunosuppression, MCC might occur in a younger age group significantly. The pathogenesis of MCC is really as however not really grasped [1] totally, but the latest demonstration the fact that Merkel cell polyoma pathogen (MCV) DNA is generally within MCC suggests a viral R935788 induced carcinogenesis [2], [3]. Regardless ...
Treatment of 26 patients with advanced previously untreated Merkel cell carcinoma with Keytruda® (pembrolizumab) every three weeks resulted in an overall response rate of 56% suggesting this novel therapy could represent a new treatment option for these hard to treat cancers. Merkel cell carcinoma is a rare aggressive skin cancer with limited treatment options for […]. ...
We have recently discovered a new human polyomavirus monoclonally-integrated into human Merkel cell carcinomas (MCC) that we call Merkel cell polyomavirus (MCPy...
Dr. Xiaohui Bi joins the lab to work on molecular and biological studies of Merkel cell carcinoma. She will use high resolution array-comparative genomic hybridization (CGH) to discover chromosomal copy number alterations (CNAs) that may indicate tumor suppressors (loss of region) and oncogenes (gain of region) in collaboration with Dr. Lynda Chin at the Dana-Farber Cancer Institute. She will also use large scale lentiviral siRNA-based screening in Merkel cell carcinoma cell lines to search for kinases/signaling pathways that are essential for this cell type to grow. siRNA-based screening will be a collaboration with Dr. William Hahn at the Dana-Farber Cancer Institute. Dr. Bi brings a high level of experience in cancer biology and cell cycle biology with her from her postdoctoral fellowship with Dr. Cyrus Vaziri at Boston Medical Center.. ...
Sentinel lymph node biopsy (SLNB) is commonly recommended for patients with primary Merkel cell carcinoma (MCC). However, it is critically discussed whether survival rates improve by SLNB in MCC patients in general or in subgroups of higher risk (e.g. with primary tumor size ,1 cm). The present study correlates clinical data, histology and lymph node status with follow-up and survival data to see if subgroups can be identified for modification of the current recommendations. The medical records of 47 patients with histologically confirmed MCC treated between 1995 and 2010 at a German dermatosurgery department were reviewed. Nineteen patients with excision of the primary tumor and SLNB were compared to 28 patients with excision of the primary tumor but without SLNB. End-points of this study were disease-free survival (DFS) and overall survival (OS). In addition, clinical course was correlated with tumor size and size of safety margin. The group of patients who received SLNB showed a significant ...
Clinical trial for sclc | small cell carcinoma | Small Cell Lung Cancer | Neuroendocrine carcinoma | small cell carcinoma of the lung | Merkel cell carcinoma | Neuroendocrine Carcinoma , Safety and Efficacy of XmAb18087 Pembrolizumab in Advanced Merkel Cell Carcinoma or Extensive-stage Small Cell Lung Cancer
Many unanswered questions remain about what constitutes appropriate guidelines for treatment of Merkel cell carcinoma (MCC). In this review, we address current uncertainty surrounding optimal management of Merkel cell carcinoma. These areas of uncertainty include early recognition features; clinical and histopathologic prognostic factors; optimum margins of excision of the primary tumor; indications for and value of surgical staging of the clinically negative regional nodes; optimum management of the patient with pathologically positive regional nodes; and indications for and value of radiation to the primary and regional nodes. Through identifying and elaborating on these areas of uncertainty, the authors hope to foster additional research and ultimately improve the evidence base for future iterations of the NCCN Clinical Practice Guidelines in Oncology in this rare but increasingly encountered cutaneous malignancy. The intent, however, is not to exhaustively identify all areas of controversy, ...
At Moffitt Cancer Center, our oncologists can expertly diagnose any patient who presents with the signs of Merkel cell carcinoma, then stage the cancer following a diagnosis, as we have extensive experience treating even the rarest forms of skin cancer. Appointments are available with or without a physicians referral.. Our oncologists can provide additional information about the Merkel cell carcinoma staging process and the treatment options available for metastatic and non-metastatic skin cancers. To schedule a consultation, call 1-888-663-3488 or submit a new patient registration form online.. ...
Merkel cell carcinoma is a rare and aggressive malignancy of the skin. Approximately 2000 cases of Merkel cell carcinoma have been reported since its first publ
What is Merkel Cell Carcinoma? Get the facts about Merkel Cell Carcinoma symptoms, testing, treatment and care options from trusted sources.
What is Merkel Cell Carcinoma? Get the facts about Merkel Cell Carcinoma symptoms, testing, treatment and care options from trusted sources.
NEW YORK, June 29, 2017 /PRNewswire/ -- Merkel Cell Carcinoma - Pipeline Review, H1 2017. Merkel Cell Carcinoma - Pipeline Review, H1 2017.
Merkel cell carcinoma (also known as a Cutaneous apudoma, Primary neuroendocrine carcinoma of the skin, Primary small cell carcinoma of the skin, and Trabecular carcinoma of the skin is a rare and highly aggressive cancer in which malignant cancer cells develop on or just beneath the skin and in hair follicles.. • The majority of Merkel cell carcinomas appear to be caused in part by a newly discovered virus, Merkel cell polyomavirus or MCV. Direct evidence for this comes from studies showing that inhibition of MCV proteins causes MCV-infected Merkel carcinoma cells to die but has no effect on tumor cells from Merkel cell carcinomas that are not infected with the virus. • This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Once it has metastasized to the lymph nodes, the 5-year survival rate for a patient is about 50 percent. A patient with a small tumor (less than 2 cm) that has not metastasized to the lymph nodes may have a 5-year survival rate of more than 80 ...
The FDA has granted an accelerated approval to pembrolizumab for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma.
Cabozantinib (XL184) is an inhibitor of multiple receptor tyrosine kinases and was approved by the U.S. Food and Drug Administration (FDA) on 29 November 2012 for the treatment of patients with progressive, metastatic medullary thyroid cancer. It is commercially available as COMETRIQ™ in the United States.. During the Pre Treatment Period, participants are consented and qualified (screened) for the study. Treatment will be administered on an outpatient basis.. Each treatment cycle lasts 28 days, during which time the participant will be taking the study drug, cabozantinib, once daily. The participant will be given a study drug-dosing diary for each treatment cycle. The diary will also include special instructions for taking the study drug.. - Participants will be followed for 8 weeks after removal from study or until death, whichever occurs first. Participants removed from study for unacceptable adverse events will be followed until resolution or stabilization of the adverse event. ...
Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations af …
Merkel cell carcinoma (MCC) is one of the most aggressive cancers of the skin. RASSFs are a family of tumor suppressors that are frequently inactivated by promoter hypermethylation in various cancers. We studied CpG island promoter hypermethylation in MCC of RASSF2, RASSF5A, RASSF5C and RASSF10 by combined bisulfite restriction analysis (COBRA) in MCC samples and control tissue. We found RASSF2 to be methylated in three out of 43 (7%), RASSF5A in 17 out of 39 (44%, but also 43% in normal tissue), RASSF5C in two out of 26 (8%) and RASSF10 in 19 out of 84 (23%) of the cancer samples. No correlation between the methylation status of the analyzed RASSFs or between RASSF methylation and MCC characteristics (primary versus metastatic, Merkel cell polyoma virus infection, age, sex) was found. Our results show that RASSF2, RASSF5C and RASSF10 are aberrantly hypermethylated in MCC to a varying degree and this might contribute to Merkel cell carcinogenesis.
Merkel cell carcinoma (MCC) was originally described by Toker in 1972 as trabecular carcinoma of the skin.[1] Other names include Toker tumor, primary small cell carcinoma of the skin, primary cutaneous neuroendocrine tumor, and malignant trichodiscoma.[2] MCC is an aggressive neuroendocrine carcinoma arising in the...
Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin cancer. To diagnose nodal MCC with an unknown primary disease is challenging, and it has to be separated from other nodal metastatic neoplasms. We report a unique case of nodal MCC in head and neck lesions with an unknown primary. A 70-year-old woman was admitted to our department with a right submandibular mass. Fine needle aspiration biopsy was performed and indicated malignancy. F-18-fluorodeoxyglucose positron emission tomography (PET) demonstrated abnormal accumulation in the right submandibular lymph node, right palatine tonsil, and right thyroid gland. For diagnostics and treatment, bilateral selective neck lymph node dissection, right tonsillectomy, and right thyroidectomy were performed. Histopathological examination revealed that most parts of the submandibular lymph node were occupied by diffuse sheets of tumor cells. Contrary to our expectation, malignant cells were not detected in the right palatine tonsil and ...
Background: There are limited data on the travel burden for cancer patients with rare tumor types, such as Merkel cell carcinoma (MCC).. Objective: The objective of this study was to understand the travel burden of MCC patients.. Methods: This study used data from an MCC registry at the Seattle Cancer Care Alliance (SCCA). All MCC patients enrolled at SCCA with a valid 3-digit ZIP code were included. Patients were followed up from January 1, 2012 until their last follow-up, death, or end of data (January 1, 2017). Travel burden was measured by one-way travel distance to SCCA from each patients 3-digit ZIP code. Patient demographics, tumor characteristics, and follow-up visit were evaluated and stratified by one-way driving distance of ≤300 and ,300 miles.. Results: A total of 391 MCC patients were included (68% men, mean age = 67 years [±SD = ±11 years], 67% residing in the West, and 70% white). At diagnosis, 53% of the patients had Stage III or IV MCC. Mean one-way distance traveled by ...
Merkel cell carcinoma, also known as primary cutaneous neuroendocrine carcinoma,1 was characterized in 1972.2 It is a rare but challenging neuroendocrine cancer of the skin that may sometimes be misdiagnosed as basal cell carcinoma.3 The differential diagnosis may include lymphoma, small cell melanoma, metastatic small cell lung cancer to the skin, and other cutaneous small round cell neoplasms.1 Confirming a diagnosis, therefore, requires histopathologic and immunohistochemical studies. Unfortunately, this malignancy is aggressive, frequently metastatic, and the prognosis is generally poor. More than one third of patients (33% to 46%) die of their disease.4,5. In many cases, Merkel cell polyomavirus is a contributing factor to the development of Merkel cell carcinoma6; somatic mutations induced by ultraviolet light exposure and subsequent DNA damage likely also contribute to the development of the disease.7 There is a higher incidence of Merkel cell carcinoma among immunosuppressed individuals, ...
An NCI Cancer Currents blog post about results from a phase II clinical trial showing durable tumor responses to the immunotherapy drug avelumab in patients with metastatic Merkel cell carcinoma.
The ICD-10 Code C7B.1 is the code used for Secondary Merkel cell carcinoma .An alternative description for this code is Secondary Merkel cell ...
Merkel cell carcinoma is an aggressive neuroendocrine cutaneous malignancy with a predilection for regional and distant metastasis. This malignancy presents most commonly on the head and neck of elderly Caucasian males, with a higher prevalence in the immunosuppressed. A high index of suspicion must be maintained due to the often asymptomatic presentation. Lip tumors, scalp tumors, local invasion, nodal metastasis, distant metastasis, and lymphovascular invasion are poor prognostic factors. Up to 8.7% of patients present with distant metastasis, and PET-CT is an accurate staging tool with a 90% sensitivity. Combined aggressive surgical resection with adjuvant radiotherapy affords the best regional control rates. The regional lymphatics must be addressed with either sentinel lymph node biopsy, surgery, or elective radiation due to the risk of occult metastasis. Addition of chemotherapy has no proven benefit in locoregional control.
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increase the sensitivity of detection of MCPyV in MCC by developing antibodies capable of detecting large T antigen by immunohistochemistry. In addition, we expanded the repertoire of quantitative PCR primers specific for MCPyV to improve the detection of viral DNA in MCC. Here we report that a novel monoclonal antibody detected MCPyV large T antigen expression in 56 of 58 (97%) unique MCC tumors. PCR analysis specifically detected viral DNA in all 60 unique MCC tumors tested. We also detected inactivating point substitution mutations of TP53 in the two MCC specimens that lacked large T antigen expression and in ...
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 extranodal tissue samples. MCPyV DNA was detected by quantitative PCR in 13 (6.6%) of 196 lymphomas, including 5 (20.8%) of 24 chronic lymphocytic leukemia specimens, and in 11 (10%) of 110 benign lymph nodes, including 8 (13.1%) of 61 samples of reactive hyperplasia and 3 (10.3%) of 29 normal lymph nodes. Other samples were MCPyV negative. Sequence analysis of 9 virus-positive samples confirmed the identity of MCPyV; 3 viral strains were represented. Immunohistochemical testing showed that 1 T-cell lymphoma expressed MCPyV T-antigen. These findings suggest that the lymphoid system plays a role in MCPyV infection and may be a site for MCPyV persistence.
TY - JOUR. T1 - Dermoscopy of merkel cell carcinoma. AU - Dalle, Stéphane. AU - Parmentier, Laurent. AU - Moscarella, Elvira. AU - Phan, Alice. AU - Argenziano, Giuseppe. AU - Thomas, Luc. PY - 2012/5. Y1 - 2012/5. N2 - Introduction: Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor whose clinical presentation, usually a pink nodule, is not specific. We aimed in this study to determine the dermoscopic criteria encountered in MCC. Methods: From our image database we selected the patients diagnosed with MCC and scored the dermoscopic criteria shown by these tumors. Results: Ten patients coming from three different academic hospitals were studied. Vascular structures were the more relevant dermoscopic features. In 8 out of 10 (80%) patients a polymorphic vascular pattern was seen, composed of milky-red clods/areas in association with one or more additional vascular structures. Conclusion: Although an overlap existed between the dermoscopic features observed in MCC and amelanotic ...
To assess the usefulness of using cutaneous swabs to detect Merkel cell polyomavirus (MCPyV) DNA, we analyzed swabs from persons with Merkel cell carcinoma (MCC), others with skin diseases, and healthy volunteers. MCPyV was detected in at least 1 sample from virtually all participants. Viral loads were higher in samples from patients with MCC.
a_benign_virus_normally_found_in_the_skin_can_lead_to_a_type_of_rare_lethal_skin_cancer_specifically_infection_by_the_merkel_cell_polyomavirus_can_lead_to_merkel_cell_carcinoma_in_immunecompromised_individuals_researchers_have_now_identified_a_type_of_skin_cell_as_the_target_of_the_virus_in_humans_this_study_from_the_perelman_school_of_medicine_at_the_university_of_pennsylvania_establis
Merkel cells are mechanosensitive skin cells whose production requires the basic helix-loop-helix transcription factor Atoh1. We induced ectopic Atoh1 expression in the skin of transgenic mice to determine whether Atoh1 was sufficient to create additional Merkel cells. In embryos, ectopic Atoh1 expression drove ectopic expression of the Merkel cell marker keratin 8 (K8) throughout the epidermis. Epidermal Atoh1 induction in adolescent mice similarly drove widespread K8 expression in glabrous skin of the paws, but in the whisker pads and body skin ectopic K8+ cells were confined to hair follicles and absent from interfollicular regions. Ectopic K8+ cells acquired several characteristics of mature Merkel cells in a time frame similar to that seen during postnatal development of normal Merkel cells. Although ectopic K8+ cell numbers decreased over time, small numbers of these cells remained in deep regions of body skin hair follicles at 3 months post-induction. In adult mice, greater numbers of ...
Author Summary Polyomaviruses occupy a replicative niche in animals from birds to humans. Two human polyomaviruses, BKV and JCV, were discovered in 1971 and within the last two years, three new polyomaviruses have been found in humans: KI (KIV), WU (WUV), and Merkel Cell (MCV) polyomavirus. MCV was identified in Merkel Cell carcinomas, a rare skin cancer. To date, it has not been determined what percentage of the human population is exposed to KIV, WUV, and MCV, and when initial exposure to these viruses occurs. We determined that initial exposure to KIV, WUV, and MCV occurs in childhood, similar to that for the known human polyomaviruses BKV and JCV, and that their prevalence is high. We also found evidence that a monkey virus, Lymphotropic Polyomavirus (LPV), likely has a serologically related human counterpart. Another monkey polyomavirus, SV40, was found at ∼2% prevalence, a level that does not support its role in human disease.
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A retrospective molecular case-control study was conducted in Non-small-cell lung-cancer patients and their relatives. During the screening program, 106 patient samples (including 77 serum biopsies and 29 parafin embedded tissues) and 90 non-cancer counterparts (50 serum biopsies and 40 parafin embedded tissues) were recruited for being analyzed by realtime-PCR and sequencing. ...
Merkel cell cancer is also known as neuroendocrine cancer of the skin or trabecular cancer. Characterized by firm, shiny skin lumps, this rare cancer develops on or just beneath the skin and in the hair follicles. Merkel cell cancer most often is found on sun-exposed areas of skin, such as the neck and head. The cancer mostly affects Caucasian people over age 50. The cause of the cancer is unknown, but it is believed to be related to both sun exposure and suppression of the immune system.. ...
Merkel cell cancer is also known as neuroendocrine cancer of the skin or trabecular cancer. Characterized by firm, shiny skin lumps, this rare cancer develops on or just beneath the skin and in the hair follicles. Merkel cell cancer most often is found on sun-exposed areas of skin, such as the neck and head. The cancer mostly affects Caucasian people over age 50. The cause of the cancer is unknown, but it is believed to be related to both sun exposure and suppression of the immune system.. ...
Less Common Skin Cancers. Merkel Cell Carcinoma is a rare and aggressive form of skin cancer. It arises from Merkel cells in the lower part of the epidermis. Merkel cells are similar to nerve cells and give the skin touch sensation. Treatment involves a team approach from physicians with significant experience with the disease.. Atypical Fibroxanthoma is thought to arise from the dermis, which is deeper than the epidermis, the source of most other skin cancers. It classically appears on the face or scalp as a reddish, sometimes glistening plaque (broad, raised area on the skin).. Microcystic Adnexal Carcinoma is thought to be derived from cells that produce the adnexal structures, such as hair follicles and sweat glands in the skin. It classically occurs on the face. It may have a deceivingly benign appearance and may be mistaken for a common melanocytic nevus (mole ...
Learn about the sentinel lymph node biopsy and the role it plays in detecting Merkel cell carcinoma, a rare and aggressive skin cancer.
Merkel cells are found in the skin and some parts of the mucosa of all vertebrates. In mammalian skin, they are clear cells found in the stratum basale (at the bottom of sweat duct ridges) of the epidermis approximately 10 μm in diameter. They also occur in epidermal invaginations of the plantar foot surface called rete ridges.[6] Most often, they are associated with sensory nerve endings, when they are known as Merkel nerve endings (also called a Merkel cell-neurite complex). They are associated with slowly adapting (SA1) somatosensory nerve fibers. They react to low vibrations (5-15 Hz) and deep static touch such as shapes and edges. Due to a small receptive field (extremely detailed info) they are used in areas like fingertips the most; they are not covered (shelled) and thus respond to pressures over long periods. ...
Define Merkel disk. Merkel disk synonyms, Merkel disk pronunciation, Merkel disk translation, English dictionary definition of Merkel disk. also disc n. 1. A thin, flat, circular object or plate. 2. Something resembling such an object: The moons disk was reflected in the pond. 3. a.
Only seven human viruses cause nearly 20% of cancers world-wide. Our lab discovered two of these seven viruses: Kaposi sarcoma herpesvirus (KSHV or HHV8) in 1994 and Merkel cell polyomavirus (MCV). We also developed digital transcriptome subtraction, which was the first non-directed mRNA sequencing approach to find new human viruses.. Because cancer viruses contain the genetic information needed to cause cancer, they have been critical to understanding how cancer cells arise, even for those cancers that are not caused by infection. Our lab has two broad focus areas: first, we seek to find new ways to identify human cancer viruses, including high-throughput genomics and proteomics. Second, we study viral oncogenes to understand how they act to turn a healthy cell into a cancer cell.. If you want to learn more, please look at our publications page here for full-text articles. If you are a Pitt student or a postdoc interested in this research, contact us here, or learn more about the Cancer ...
Surgical excision is the gold standard for management of most eyelid and facial skin cancers. A majority of skin cancers in the eyelid area are either basal cell carcinoma or squamous cell carcinoma. Other cancer types (such as sebacous cell carcinoma, malignant melanoma, and Merkel cell carcinoma) occur more infrequently and generally require wider excision, more specialized resection and reconstruction techniques, and a comprehensive oncologic (cancer) evaluation.. There are two basic approaches to basal cell and squamous cell carcinoma excision. Skin cancer removal can be performed at the time of reconstruction and the tumor margins examined (Frozen Sections) by a pathologist to ensure complete removal. Alternatively, microscopic-assisted resection may be performed by a dermatologic surgeon (Mohs Surgery). This technique offers the potential advantages of less tissue removal and slightly greater confidence of complete cancer resection.. Following Mohs skin cancer resection, ...
Rapid restoration of virus-specific T immunity via adoptive transfer of ex vivo generated T cells has been proven as a powerful therapy for patients with advanced cancers and refractory viral infections such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV). BK virus (BKV), John Cunningham virus (JCV), and Merkel cell carcinoma virus (MCV) are the members of the rapidly growing human polyomavirus (hPyV) family that commonly infects most healthy humans. These viruses have a clearly established potential for causing severe end-organ damage or malignant transformation, especially in individuals with weakened immunity who are unable to mount or regain endogenous T-cell responses as a result of underlying leukemia or iatrogenic immunosuppression in autoimmunity, bone marrow and solid organ transplant settings ...
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. Keratin 20 is a type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells and is specifically found in the gastric and intestinal mucosa. In immunohistochemistry, antibodies to CK20 can be used to identify a range of adenocarcinoma arising from epithelia that normally contain the CK20 protein. For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but is absent in lung cancer, prostate cancer, and non-mucinous ...
At present, it is in phase III clinical trials at Novartis for the treatment of carcinoid tumors and symptoms that are not adequately controlled by somatostatin analogues (Sandostatin). Phase II clinical development is also under way at the company for the treatment of gastric dumping syndrome, metastatic carcinoid tumors, meningioma and pituitary adenoma and for the treatment of hepatocellular carcinoma in combination with everolimus. Early clinical trials are also ongoing for the treatment of patients with metastatic melanoma or Merkel cell carcinoma. A phase I clinical trial for the treatment of alcoholic cirrhosis has been completed. The company intends to file for approval in 2007 for these indications. Novartis and Thomas Jefferson University are conducting phase II clinical trials for the treatment of prostate cancer, alone or in combination with everolimus. The Mayo Clinic is conducting phase II clinical trials for the treatment of polycystic liver disease. Phase III clinical trials had ...
The UCLA team collaborated with researchers from the Moffitt Cancer Center, the MD Anderson Cancer Center, the University of California San Francisco, Northwestern University Medical Center ...
BERLIN (Reuters) - Chancellor Angela Merkel expressed her support on Wednesday for setting a quota for women on the executive boards of Germanys top listed companies, building on a 30% quota for women on supervisory boards introduced in 2015.. Merkel, a Christian Democrat who had long resisted quotas, said she is talking to Family Minister Franziska Giffey, who proposed legislation on the issue in February, but saw the topic sidelined during the coronavirus lockdown.. It is absolutely inadequate that there are still listed companies with not a single woman sitting on the board, Merkel told parliament, noting that companies had found enough female candidates for their supervisory boards to meet the quota.. Merkel said it could take time for her coalition government to reach an agreement on the subject, but suggested she hoped it would happen before next years parliamentary election, when she has said she will not run for another term.. While women made up 28% of the supervisory boards of ...
Friedrich Sigmund Merkel (5 April 1845 - 28 May 1919) was a leading German anatomist and histopathologist of the late 19th century. In 1875, he provided the first full description of Tastzellen (touch cells) which occur in the skin of all vertebrates. They were subsequently given the eponym Merkel cells in 1878 by Robert Bonnet (1851-1921). Merkel was a native of Nürnberg. In 1869 he earned his medical doctorate from the University of Erlangen, becoming habilitated in the field of anatomy during the following year. He was a professor at the Universities of Rostock (from 1872), Königsberg (from 1883), Göttingen (from 1885), and Rostock (from 1872). At Göttingen, he worked under Jacob Henle and married Henles daughter Anne. He published a multivolume textbook on human anatomy and originated the color scheme used by most anatomy texts today: red for arteries, blue for veins, and yellow for nerves. He introduced xylene as a clearing agent in histology, and it is still used today Two of his ...
A 2-year-old Indian girl is suffering from a rare skin disease, lamellar ichthyosis. It affects just one in every 600,000 people.
CANBY, Ore. - An 8-year-old Arkansas boy with a rare skin disorder met a dog in Oregon with the same condition and its something the boy and his mom say they will never forget.
2014 November 6-7: Towards a network of excellence for rare skin diseases in the North Africa and the wider Middle-East area - Beirut - Lebanon (...)
One of the most iconic pictures of 2016 is a photo taken at the May G7 summit in Japan. It shows Barack Obama, Francois Hollande, David Cameron, and Matteo Renzi smiling and waving at the camera, while Angela Merkel looks on, fingers steepled, in her signature pose exuding both serenity and self-restraint. The men in the picture seemed nervous, and had every reason to be. By years end, each would have been forced to make way for populist energies in their respective countries.. A consensus has now emerged among foreign-policy elites that the departure from the international stage of the other four men has left Angela Merkel as the only person capable of upholding the tenets of the global liberal order. The last hope for the free world, they suggest, rests on Merkels reelection in the fall of 2017. Those hopes are dangerously misguided. Giving Merkel the mantle of moral leadership is based on a misreading of her past eleven years in office. It assumes that Merkels three coalitions in Germany ...
Instead, she uttered platitudes, within could help patients shed up to FIVE stone in six months - and cut their. But these figures, while reflecting Covid vaccines in a day are almost meaningless in comparison to hit 15m first doses benefits of US military aid - above all, American boots on the ground in Istanbul.. Europe Angela Merkel meets Erdogan Merkel official direct US military aid, brief visit, Chancellor Merkel plans to address multiple topics with President Erdogan, from regional conflicts to human rights issues.. Turkey has established a controversial safe zone there, not only for those fleeing civil war to the real costs and also to persecute and displace Kurds.. Opinion: For life after Stranger Things Hopper, vaccinated must be patient ECONOMY Container shipping sector navigates COVID pandemic Maritime container freight shipping.. Stattdessen senden sie eine chiffrierte Flirt mit Isabelle Reichenbach ein Video sind schon so viele von GZSZ sind montagmorgens genauso Chancen beim ...
German Chancellor, Angela Merkel, said on Sunday she would meet British Prime Minister, Boris Johnson, on Wednesday evening to discuss Britains planned departure from the European Union.. She added that Berlin was also prepared for a disorderly Brexit.. Johnson is seeking to persuade European Union leaders to reopen Brexit talks or face the prospect of its second-largest member leaving abruptly on Oct. 31 with no deal in place to mitigate the economic shock - a move that businesses expect would cause major disruption.. We are glad of every visit, and you have to talk, and you have to find good solutions, Merkel said during a panel discussion at the Chancellery.. We are prepared for any outcome, we can say that, even if we do not get an agreement. ...
Merkel became the first female Chancellor of Germany in 2005 and is serving her fourth term. In November 2018, Merkel stepped down as leader of the Christian Democratic Union and announced she wouldnt seek another term as chancellor in 2021.
Prime Minister Kaja Kallas (Reform) is set to meet with German Chancellor Angela Merkel, early next week. Merkel is set to meet Russian President Vladimir Putin the following Friday.
Merkel 147 SL 20 Gauge SxS Shotgun |br >|br > L.L. BEAN 100th ANNIVERSARY, #5 of 20 TOTAL |br >|br > General Specs: Merkel, Year 2 for sale by Vintage Firearms Inc on GunsAmerica - 981124496
BERLIN (AP) - Germans go to the polls on Sunday to elect a new parliament and produce a new German leader after 16 years of having Angela Merkel at the helm. Merkel decided not to run for a fifth term and the election campaign has largely focused on the three candidates hoping to succeed.... ...
An impressive and important paper showing that Merkel Cells use serotonin to signal directly to A-beta afferents. http://www.pnas.org/content/113/37/E5491
We are doing this study to learn if we can lower the chance of your cancer growing back by adding the study drug (Pembrolizumab)... | View the details of this clinical trial.
Disruptions of the sense of touch are inherent to many inherited and acquired human disorders that affect the skin and/or peripheral nervous system. These disor...
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Hundreds of patients with a type of aggressive skin cancer will be offered a targeted therapy on the NHS in England and Wales, which reduces the risk of it returning. At present, they have to hope their cancer will not return after surgery. The drug has been shown to improve the survival of people with stage III melanoma, with a particular mutation. A skin cancer charity said making the treatment available on the NHS was a huge step forward. Melanoma is the most aggressive type of skin cancer,
Finishing up the last semester of college and simultaneously preparing for a June wedding might seem exciting, if a little daunting.. For Sharon Belvin, health and wellness educator for UPMC Susquehanna, it was a whirlwind of stress and fear.. Belvin was a runner and noticed breathing was becoming more difficult for her rather than getting easier as she got used to her pace.. It got to the point I was huffing and puffing just walking around, she said.. She said time after time health providers passed her breathing trouble off as colds, pneumonia or bronchitis. But, in March of 2004, Belvin noticed a mass below her left collar bone and feared breast cancer.. Instead, a biopsy revealed stage 4 melanoma, an aggressive skin cancer which already had spread to her lungs.. At one point, I had a tumor in my lung the size of a football, Belvin recalled.. She started chemotherapy almost immediately. Though she went through with her wedding, she said she had to scale things back immensely.. Chemo ...
His baseball cap planted for action, his good arm cradling the space where his right arm used to be, Michael Sammy Samuelson walked up to St. Paul Mayor Chris Coleman at a DFL gathering two years ago and told him exactly what he thought of his policies.. The colorful words that spilled out of his mouth were not flattering. Coleman jabbed back, calling Samuelson the most negative man in St. Paul - all said with a smile. Samuelson - a friend and foil to generations of St. Paul political leaders, team owners, radio show hosts and stadium proponents - embraced opportunities to heckle those he considered misinformed, amp up the volume on a debate or otherwise right wrongs with his eccentric, school-boy energy. Samuelson, 57, died Monday, Jan. 29, of complications related to a lifetime of complications, including the aggressive skin cancer that in recent years forced the amputation of his right arm and shoulder. He was diagnosed last year with myelodysplastic syndrome, or MDS, a blood cancer, and ...
In cases where the limbus is destroyed there has been little hope to restore the patients sight. Professor De Lucas team decided to take a leaf from the way that burns are treated and grow a new cornea from limbar stem cells taken from the healthy eye. By removing a small sample of these cells it was possible to culture a new cornea and graft it on to the damaged eye. The team showed that of 240 patients who were operated on in this way, the cornea regenerated successfully in 70% of cases. The researchers then turned their attention to a rare but debilitating genetic disease of the skin resulting in a syndrome known as Epidermolysis Bullosa, in which the skin is highly fragile and prone to blistering due to faulty proteins that effectively anchor the surface layers of skin to the body. In one form of the disease there is a mutation in one of these anchoring proteins called laminin 5. The Italian researchers obtained consent to carry out a small-scale trial of a novel gene therapy using skin ...
Cheri and Phillip Lindsay both have a rare condition that causes them to gradually lose skin pigment in patches. But it was easier for her to deal with it, Cheri says, because of her dads example.
Sara Geurts was diagnosed with a connective tissue disorder called Ehlers-Danlos Syndrome, which means she lacks collagen in her skin.
DOC --| Over 60 patient representatives from 30 countries gathered for the official launch and inaugural meeting of Rare Diseases International (...)
The Health Department said there have been 30 reported cases of the infection caused by a bacterium called Mycobacterium marinum.
Angela Dorothea Merkel (nee Kasner; born 17 July 1954) is a German politician who has been Chancellor of Germany since 2005. She served as Leader of the Opposition from 2002 to 2005 and as Leader of the Christian Democratic Union (CDU) from 2000 to 2018. A member of the Christian Democratic Union, Merkel is the first female chancellor of Germany. Merkel has been widely described as the de facto leader of the European Union, the most powerful woman in the world, and by many commentators since 2016 as the leader of the free world. Merkel, who has served as Germanys chancellor since 2005, earned the honour of Time Person of the Year in 2015. In her profile, Time observed that …her political style was not to have one; no flair, no flourishes, no charisma, just a survivors sharp sense of power and a scientists devotion to data. Her educational background (a Ph.D. in quantum chemistry) has taught her to take a methodical, low-key approach to problem-solving. Though the world of politics can ...
"Merkel cell carcinoma". Journal of the National Comprehensive Cancer Network. 7 (3): 322-32. doi:10.6004/jnccn.2009.0024. PMID ... His work has also extended to serving on expert panels such as those dedicated to merkel cell cancer and guidelines of care. He ... Alam, Murad; Ratner, Désirée (2001). "Cutaneous Squamous-Cell Carcinoma". New England Journal of Medicine. 344 (13): 975-83. ...
Vazmitel M, Michal M, Kazakov DV (2007). "Merkel cell carcinoma and Azzopardi phenomenon". Am J Dermatopathol. 29 (3): 314-5. ... It can occur in small cell carcinomas and in some high-grade malignant neoplasms. The effect is well known in diagnostic ... Azzopardi JG (1959). "Oat-cell carcinoma of the bronchus". J Pathol Bacteriol. 78 (2): 513-9. doi:10.1002/path.1700780218. PMID ... Case Studies Azzopardi phenomenon in a metastatic small cell carcinoma of the lung (All articles with unsourced statements, ...
Beylergil V, Perez JA, Osborne JR (2016). "Molecular Imaging of Merkel Cell Carcinoma". In Hamblin MR, Avci P, Gupta GK (eds ... With iodine-131 it can also be used to treat tumor cells that take up and metabolize norepinephrine. MIBG is absorbed by and ... is a radiolabeled analogue of guanethidine that enters the cells via the norepinephrine transporter and is either stored in the ... is transported to and stored in the distal storage granules of chromaffin cells in the same way as norepinephrine. "Iobenguane ...
"Merkel cell carcinoma and HIV infection." The Lancet 359, no. 9305 (2002): 497-498. "Morten Frisch". SSI. Retrieved 21 August ...
... adenocarcinoma and squamous carcinoma. Merkel cell carcinoma Lung cancer "VM618 Glossary". Archived from the original on 2016- ... It is a feature of small cell carcinomas and particularly useful for differentiation of small cell and non-small cell ... "Cytopathologic differential diagnosis of small cell carcinoma and poorly differentiated non-small cell carcinoma in bronchial ... In histopathology, nuclear moulding, also nuclear molding, is conformity of adjacent cell nuclei to one another. ...
Orouji E, Peitsch WK, Orouji A, Houben R, Utikal J (January 2020). "6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma". ... A recent study demonstrates the presence of m6A in the small T antigen of Merkel cell polyomavirus (MCPyV) in Merkel cell ... Mammalian viral transcripts must function in a mammalian cell, so they must acquire the same epigenetic marks as the host cell ... Nevertheless, m6A levels vary between different RNAs within a cell and between different cell types of the same organism. The ...
Mitoses are uncommon when compared to basal cell carcinoma. Trichoepiteliomas often contain Merkel cells; an immunostain for ... Its appearance is similar to basal cell carcinoma. One form has been mapped to chromosome 9p21. Trichoepitheliomas may be ... They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. ... "Histologic Mimics of Basal Cell Carcinoma". Archives of Pathology & Laboratory Medicine. 141 (11): 1490-1502. doi:10.5858/arpa. ...
Merkel cell carcinoma. Alexander Kibrik, 73, Russian linguist (Moscow State University), after long illness. Fernando Ortíz, 89 ... Naoki Miyamoto, 77, Japanese professional Go player, hepatocellular carcinoma. Natina Reed, 32, American musician (Blaque) and ... Mohammed Mushaima, 24, Bahraini political activist, sickle cell anemia.[citation needed] Kalambadi Muhammad Musliyar, 78, ...
Results of a Phase II clinical trial in Merkel-cell carcinoma were reported in The New England Journal of Medicine in June 2016 ... Nghiem (2016). "PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma". N. Engl. J. Med. 374 (26): 2542-2552. doi: ... in Participants With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, or Non-small Cell Lung Carcinoma (P07990/ ... the first-line treatment of metastatic non-small cell lung carcinoma (NSCLC) in adults whose tumors express PD-L1 with a ≥ 50% ...
About 80% of Merkel cell carcinomas are caused by Merkel cell polyomavirus; the remaining tumors have an unknown etiology and ... Merkel cell polyomavirus is the most recently discovered human cancer virus, isolated from Merkel cell carcinoma tissues in ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... Inflammation triggered by the worm's eggs appears to be the mechanism by which squamous cell carcinoma of the bladder is caused ...
"Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid ... "Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine ... "Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma". Journal of the National Cancer ... and Merkel cell virus (MCV) with Merkel cell cancer. SV40 replicates in the kidneys of monkeys without causing disease, but can ...
... naturally infects humans and is associated with Merkel cell carcinoma (MCC), a rare form of skin cancer originating from Merkel ... of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells". Cell. ... "Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma". Science. 319 (5866): 1096-1100. Bibcode:2008Sci... ... the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to ...
... and was used to discover Merkel cell polymavirus in Merkel-cell carcinoma. Simultaneously to the MCV discovery, this approach ... Feng H, Shuda M, Chang Y, Moore PS (Jan 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". Science. ... the suspect causative agent in Merkel-cell carcinoma. Using computational subtraction to discover novel pathogens was first ... The method specifically examines the etiological agent of infectious diseases and is best known for discovering Merkel cell ...
This virus is the likely cause of Merkel-cell carcinoma and hence is named Merkel cell polyomavirus. Moore and Chang have ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ... two different human viruses causing the AIDS-related cancer Kaposi's sarcoma and the skin cancer Merkel cell carcinoma. The ... they identified the most recently discovered human polyomavirus infecting Merkel cells. ...
... and Epstein-Barr virus causing B cell lymphomas and nasopharyngeal carcinomas. Kaposi sarcoma virus and Merkel cell polyoma ... T lymphocytes are cells of the immune system that attack and destroy virus-infected cells, tumor cells and cells from ... The carcinoma cells still harbour the viral genes and antigens. As expected T cell responses against antigens encoded by genes ... This enables the T cells to eliminate cells with "foreign" or "abnormal" antigens without harming the normal cells. It has long ...
... merkel cell carcinoma. Claes Egnell, 95, Swedish sport shooter and Olympic silver medal-winning (1952) pentathlete. Manuel ... Eiko Ishioka, 72, Japanese costume designer (Bram Stoker's Dracula, Immortals, The Cell), Oscar winner (1993), pancreatic ...
... small-cell lung cancer, ovarian cancer). It has been granted Orphan drug status for Merkel cell carcinoma. It has reported ... It comprises the CD56-binding antibody, lorvotuzumab (huN901), with a maytansinoid cell-killing agent, DM1, attached using a ... "ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung ... encouraging Phase II results for small-cell lung cancer. Dimond PF (9 March 2010). "Antibody-Drug Conjugates Stage a Comeback ...
David Brudnoy, 64, American radio talk show host (Boston), Merkel cell carcinoma. Paul Edwards, 81, Austrian-born American ...
Merkel cell polyomavirus - a polyoma virus - is associated with the development of Merkel cell carcinoma Not all oncoviruses ... DTS was used to isolate DNA fragments of Merkel cell polyomavirus from a Merkel cell carcinoma and it is now believed that this ... but a recently discovered analogue called Merkel cell polyomavirus has been associated with Merkel cell carcinoma, a form of ... Feng H, Shuda M, Chang Y, Moore PS (February 2008). "Clonal integration of a polyomavirus in human Merkel cell carcinoma". ...
Shortly after these performances, on 11 September 2007, Zawinul died of Merkel cell carcinoma. The Veszprém concert was ...
"Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity". Biology. 9 (2). doi: ... Being a cytotoxin, glaucarubin is capable of killing cells, which is why it has been tested as an anti-cancer drug. Although it ... helps in the process of killing the uncontrollable cancer cells, it has the tendency to spread and cause harm to unwanted parts ...
Samlowski WE, Becker J. The Potential for Targeted Therapy of Merkel Cell Carcinoma. In Merkel Cell Carcinoma: A ... A Phase II trial of imatinib mesylate (Gleevec) in neuroendocrine carcinoma of the skin (Merkel Cell Carcinoma) (S0331). ... "A phase II trial of imatinib mesylate in Merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology ... "A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology ...
Merkel) cells and Merkel cell carcinoma". International Journal of Cancer. 101 (2): 103-10. doi:10.1002/ijc.10554. PMID ... Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian ... Du X, Jensen P, Goldowitz D, Hamre KM (May 2007). "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears ... Sekine A, Akiyama Y, Yanagihara K, Yuasa Y (June 2006). "Hath1 up-regulates gastric mucin gene expression in gastric cells". ...
Zawinul himself died on September 11, 2007, in Vienna from skin cancer (Merkel cell carcinoma). He was predeceased by mid- ...
Fitch died on October 31, 2012, of Merkel cell carcinoma at his home in Connecticut. (key) Allen Brown. "John Fitch". ... Deaths from Merkel-cell carcinoma, Hersham and Walton Motors Formula One drivers, Lehigh University alumni, Mille Miglia ...
For example, the protein is commonly found in colorectal cancer, transitional cell carcinomas and in Merkel cell carcinoma, but ... 2009). "Frequent expression of glypican-3 in Merkel cell carcinoma: an immunohistochemical study of 55 cases". Appl. ... Ishida M, Kushima R, Okabe H (2009). "Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin". Oncol ... 2009). "Detection of epithelial cells by RT-PCR targeting CEA, CK20, and TEM-8 in colorectal carcinoma patients using OncoQuick ...
... cells and Merkel cell carcinoma". Int. J. Cancer. 101 (2): 103-10. doi:10.1002/ijc.10554. PMID 12209986. S2CID 20592545. Erkman ... and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice Nolan LS, Jagutpal SS, Cadge BA, et al. (2017). " ... Cell. Biol. 23 (22): 7957-64. doi:10.1128/MCB.23.22.7957-7964.2003. PMC 262385. PMID 14585957. Strausberg RL, Feingold EA, ... 2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) ...
... is a fully human monoclonal antibody medication for the treatment of Merkel cell carcinoma, urothelial carcinoma, and renal ... For Merkel-cell carcinoma, Phase II has been reached and for NSCLC there is also a study in Phase III. In May 2017, avelumab ... The US Food and Drug Administration (FDA) approved it in March 2017 for Merkel-cell carcinoma. an aggressive type of skin ... January 2018). "Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year ...
On December 9, 2004, he succumbed to Merkel cell carcinoma after it had metastasized to his lungs and kidneys. Born in ... In September 2003, he was diagnosed with Merkel cell carcinoma, a rare form of skin cancer. After hospitalization and treatment ... Deaths from Merkel-cell carcinoma, Harvard Graduate School of Arts and Sciences alumni, Jewish agnostics, LGBT broadcasters ...
He detected HHV8 virus in classical Kaposi's sarcoma and Merkel cell polyomavirus in Merkel-cell carcinoma. European ... Committee supervising the research and terapeutic use of embrionyc and tissue stem cells" Medical Sciences Section of the ... chemokines and human beta-defensin-2 in vaginal epithelial cells, MICROBES AND INFECTION 7: (9-10) pp. 1117-1127, 2005. Nagy I ... BRAFV600E mutation in cutaneous lesions of patients with adult Langerhans cell histiocytosis, JOURNAL OF THE EUROPEAN ACADEMY ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ...
Nakatani M, Maksimovic S, Baba Y, Lumpkin EA «Mechanotransduction in epidermal Merkel cells» (en anglès). Pflugers Arch, 2015 ... fets que fan sospitar en un principi l'existència d'un carcinoma de bufeta urinària.[336] Una localització poc freqüent dels ... Jessen KR, Mirsky R «The Success and Failure of the Schwann Cell Response to Nerve Injury» (en anglès). Front Cell Neurosci, ... Peripheral Nervous System - Development and Stem Cells (en anglès). Embryonic Development & Stem Cell Compendium. LifeMap ...
Squamous-cell carcinoma. *Basal-cell carcinoma. *Merkel-cell carcinoma. *Nevus sebaceous. *Trichoepithelioma ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... red blood cells Giemsa-stained thin blood smear New England (different species have worldwide distribution) tick bites, e.g. ...
One obituary states she was diagnosed in 2016 with virulent Merkel-cell carcinoma, a rare and highly aggressive skin cancer. A ... Deaths from Merkel-cell carcinoma, World number 1 ranked female tennis players). ...
Mundy died of Merkel cell carcinoma at his home in Alexandria, Virginia, on April 2, 2014 at the age of 78. A memorial service ... Deaths from Merkel-cell carcinoma). ...
... and trichoblastic carcinomas, respectively. Some of these tumors resemble basal-cell carcinomas or adenocarcinomas. These ... The tumor tissues of trichoepithelioma-like CCS tumors may also contain Merkel cells that express the CK20 protein. ... Inactivating CYLD gene mutations occur in T-Cell Acute Lymphoblastic Leukemia, multiple myeloma, hepatocellular carcinoma, ... Kallam AR, Satyanarayana MA, Aryasomayajula S, Krishna BA (March 2016). "Basal Cell Carcinoma Developing from Trichoepithelioma ...
Merkel cell carcinoma (cutaneous apudoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the ... Solitary trichoepithelioma Spindle cell squamous cell carcinoma (spindle cell carcinoma) Spiradenoma Squamous cell carcinoma ... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ... squamous cell carcinoma in situ) Brooke-Fordyce syndrome Ceruminoma Cicatricial basal cell carcinoma (morpheaform basal cell ...
Squamous cell carcinoma not otherwise specified Basal cell carcinoma Squamous intraepithelial neoplasia Benign squamous lesions ... naevus Blue naevus Atypical melanocytic naevus of genital type Dysplastic melanocytic naevus Yolk sac Tumor Merkel cell Tumor ... Cell Physiology. 307 (1): C25-38. doi:10.1152/ajpcell.00084.2014. PMC 4080181. PMID 24788248. Taylor, Elizabeth J. (2000). ... a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears ...
2017). "Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors". Frontiers in Oncology. 7: 294. doi ... "A Prospective Blinded Evaluation of Urine-DNA Testing for Detection of Urothelial Bladder Carcinoma in Patients with Gross ... March 2020). "Droplet-digital PCR assay to detect Merkel cell polyomavirus sequences in chorionic villi from spontaneous ... September 2017). "Single Cell-Based Vector Tracing in Patients with ADA-SCID Treated with Stem Cell Gene Therapy". Molecular ...
... carcinomas of anal sacs, bladder carcinomas, urethral carcinomas, hemangiosarcomas, lymphomas, mast cell tumor, osteosarcomas, ... Monach PA, Arnold LM, Merkel PA (January 2010). "Incidence and prevention of bladder toxicity from cyclophosphamide in the ... Suggested mechanisms include: Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts Induction ... Or-Geva N, Reisner Y (March 2016). "The evolution of T-cell depletion in haploidentical stem-cell transplantation". British ...
... carcinoma, merkel cell MeSH C04.557.580.625.650.240.390 - carcinoma, small cell MeSH C04.557.580.625.650.510 - melanoma MeSH ... carcinoma, medullary MeSH C04.557.465.625.650.240.325 - carcinoma, merkel cell MeSH C04.557.465.625.650.240.390 - carcinoma, ... carcinoma, medullary MeSH C04.557.470.200.025.370.325 - carcinoma, merkel cell MeSH C04.557.470.200.025.370.390 - carcinoma, ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ...
Merkel cell carcinomas. MCV can also be found in healthy tissues from people without Merkel cell carcinoma. A complete MCV ... "Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens". Journal of Virology. 84 ... cutaneous squamous cell carcinoma, Bowen's disease, basal cell skin carcinoma, extrapulmonary small cell carcinoma, and EGFR ... "Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid ...
Deaths from Merkel-cell carcinoma, 20th-century Australian male musicians). ...
Merkel cell carcinoma. Alfred Niepieklo, 86, German footballer. Mary Lou Petty, 98, American Olympic swimmer (1936). ...
In April 2011, Brown had surgery to remove a basal-cell carcinoma from the right side of his nose. In December 2012, media ... Merkel, China, the European Union, and the self-organizing quality of the world economy." In September 2012, Brown signed ...
... only the anaplastic form has round blue cells, the more common fetal and embryonal types do not Merkel cell carcinoma ... In histopathology, a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a ... They typically represent undifferentiated cells. The predominance of blue staining is because the cells consist predominantly ... July 2008). "Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule". ...
Other types of carcinomas are rare and may include small cell, Merkel cell, clear cell, sebaceous cell or basal cell tumors. ... of penile cancers are squamous cell carcinomas. Other types of penile cancer such as Merkel cell carcinoma, small cell ... Around 95% of penile cancers are squamous cell carcinomas. They are classified into the following types: basaloid (4%) warty (6 ... Tis: Carcinoma in situ. Ta: Noninvasive verrucous carcinoma. T1a: Tumor invades subepithelial connective tissue without lymph ...
Merkel cell carcinoma, microcystic adnexal carcinoma, and multiple other skin cancers; usually with cure rates higher than for ... Basal cell carcinoma on patient's back Basal-cell carcinoma Basal cell carcinoma on the left upper back, nodular and ... squamous cell carcinoma. In a small proportion of cases, basal-cell carcinoma also develops as a result of basal-cell nevus ... Nodular basal-cell carcinoma (also known as "classic basal-cell carcinoma") accounts for 50% of all BCC. It most commonly ...
... head and neck cancer and Merkel cell carcinoma. Confirmative trials followed soon after. Studies were also conducted at the ... Failure to detect cancer cells in the sentinel node can lead to a false negative result-there may still be cancerous cells in ... "Feasibility of sentinel node detection in renal cell carcinoma: a pilot study". European Journal of Nuclear Medicine and ... "Sentinel node detection in renal cell carcinoma. A feasibility study for detection of tumour-draining lymph nodes". BJU ...
... murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. ... Gross murine leukemia virus is a retrovirus whose human counterpart is T cell lymphotropic virus I, while ...
Actinic keratosis Basal-cell carcinoma Epidermoid cyst Merkel-cell carcinoma Pilar cyst Squamous cell carcinoma Cutis verticis ... A common problem caused by excessive shedding of dead skin cells from the scalp Head lice Seborrhoeic dermatitis - a skin ...
Merkel cell carcinoma, Kaposi's sarcoma, keratoacanthoma, spindle cell tumors, sebaceous carcinomas, microcystic adnexal ... basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant melanoma. Basal-cell ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell ...
Sun exposure and having a weak immune system can affect the risk of Merkel cell carcinoma. Merkel cell carcinoma usually ... Find out more about risk factors, symptoms, tests to diagnose, prognosis, staging, and treatment for Merkel cell carcinoma. ... Merkel cell carcinoma is a rare type of skin cancer that usually starts in areas of skin exposed to the sun. ... Merkel cell carcinoma is a very rare disease in which malignant (cancer) cells form in the skin.. Merkel cells are found in the ...
... squamous cell carcinoma, or basal cell carcinoma, and more than half of all patients with stage IV disease will have a ... Origin of Merkel Cell Carcinomas No Longer Murky * Epidemiology of Nonkeratinocytic Skin Cancers Among Persons With AIDS in the ... The rate of recurrence of the rare but aggressive skin cancer Merkel cell carcinoma (MCC) is markedly higher than that for ... of patients with squamous cell carcinoma and 1% to 10% of patients with basal cell carcinoma. ...
... the term Merkel cell carcinoma is still most commonly used in view of the many similarities of the constituent tumor cell to ... Merkel cell carcinoma is a rare, aggressive, primary skin cancer exhibiting neuroendocrine differentiation. Several synonyms ... RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. Oncotarget. 2016 May ... Dermatologic Manifestations of Merkel Cell Carcinoma) and Dermatologic Manifestations of Merkel Cell Carcinoma What to Read ...
... squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. Merkel cell carcinomas ... Media related to Merkel cell carcinoma at Wikimedia Commons National Cancer Institute. "Merkel Cell Carcinoma". National ... "Immunotherapy for Merkel Cell Carcinoma , Merkel Cell Carcinoma". Retrieved 2020-05-14. Clinical trial number NCT01913691 for " ... In 1878 the term Merkel cell was coined by the anatomist Robert Bonnet (1851-1921). Merkel-cell carcinoma was first described ...
Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm; distant metastases are nearly always fatal. How ... Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma, a dermal neoplasm with cytoplasmic, ... Merkel Cell Carcinoma and Rare Appendageal Tumors * Oncology Case Challenge: A Construction Worker Who Drinks Daily Has an ... Fast Five Quiz: How Much Do You Know About Merkel Cell Carcinoma? - Medscape - May 31, 2017. ...
Merkel cell carcinoma is a rare, aggressive type of skin cancer. In this article, well discuss the causes, symptoms, ... basal cell carcinoma, or squamous cell carcinoma, are associated with an increased risk for Merkel cell carcinoma. ... Warning Signs of Merkel Cell Carcinoma. The Skin Cancer Foundation offers this "AEIOU" guide to help spot Merkel cell carcinoma ... called Merkel cell polyomavirus, plays a role in the development of many Merkel cell carcinoma cases. This virus lives on the ...
Origin of Merkel Cell Carcinomas No Longer Murky * Epidemiology of Nonkeratinocytic Skin Cancers Among Persons With AIDS in the ... "To our knowledge, this study is the largest trial of metastatic Merkel cell carcinoma ever reported," the study investigators ... They explained that large, randomized studies in this patient population are difficult because Merkel cell carcinoma - an ... Cite this: Avelumab: First Drug Ever Approved for Merkel Cell Carcinoma - Medscape - Mar 23, 2017. ...
... can cause damage to the DNA in a persons skin cells, which may lead to the development of Merkel cell carcinoma. ... Information About Merkel Cell Carcinoma Risk Factors for Individuals in St. Petersburg, FL * Facebook ... Older age - Merkel cell carcinoma is most usually diagnosed in individuals over the age of 50, though it can occur at any stage ... Petersburg, FL, who would like to discuss Merkel cell carcinoma risk factors with our experts can call 1-888-663-3488 or ...
Stay connected with the UH Now app. With this mobile app, you can find a doctor and find a location. In addition, you can log into your UH Personal Health Record and schedule an appointment. UH Now also allows you to explore health topics that are important to you. Take charge of your health by downloading UH Now today, and get health information delivered right to your fingertips.. Learn More. ...
As the incidence of merkel cell carcinoma (MCC) rises, experts say early detection and optimal management with novel treatments ... "Merkel cell carcinomas are almost never tender, so thats kind of a disconnect that should be a clue to dermatologists that it ... Merkel Cell Carcinoma Rates Rise as Treatment Options Expand. - Early detection and optimal management will be crucial to ... As the incidence of merkel cell carcinoma (MCC) rises, experts say early detection and optimal management with novel treatments ...
Downloading a figure as powerpoint requires a browser with javascript support. Enable javascript and try again For help please contact [email protected] ...
... for the treatment of adult and pediatric patients over the age of 12 with metastatic Merkel cell carcinoma, including those who ... "While skin cancer is one of the most common cancers, patients with a rare form called Merkel cell cancer have not had an ... Overall, 65.9 percent of patients were PD-L1-positive and 52.3 percent were positive for the Merkel cell polyomavirus (MCPyV). ... FDA Approves Bavencio for Merkel Cell Carcinoma. .social-ris-container { display: flex; justify-content: space-between; } @ ...
The availability of specific ICD diagnostic codes for Merkel Cell Carcinoma has improved the understanding and management of ... What are the ICD-10 Codes for Merkel Cell Carcinoma?. by Julie Clements , Jun 29, 2021 , Blog, ICD 10 Coding , 0 comments ... Merkel Cell Carcinoma (MCC) is a rare, aggressive type of skin cancer. MCC usually develops as a painless, firm bump that can ... Code C4A.8: Merkel cell carcinoma of other sites includes the sites of genital and buttock. "Specified site not elsewhere ...
Merkel cell carcinoma (MCC) staging is a way to understand how much the cancer has grown and how far it has spread. Learn more ... Merkel cell carcinoma is most frequently diagnosed after a patient notices skin changes and visits the doctor, where a biopsy ... Merkel Cell Carcinoma *Merkel Cell Carcinoma Risk Factors. *Merkel Cell Carcinoma Warning Signs and Images ... After testing is finished, your medical team will try to pinpoint how far the Merkel cell carcinoma (MCC) has progressed. This ...
... the First Immunotherapy Approved for Metastatic Merkel Cell Carcinoma ... "Merkel cell carcinoma is rarer than some of the more well-known skin cancers, however, its very aggressive and the proportion ... "Today is a significant milestone for people fighting metastatic Merkel cell carcinoma, who until now have not had any options ... Pathologic Nodal Evaluation Improves Prognostic Accuracy in Merkel Cell Carcinoma: Analysis of 5,823 Cases as the Basis of the ...
Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus View in MDC Repository ... Purpose: The causative agent of most cases of Merkel cell carcinoma (MCC) has been identified as the Merkel cell polyomavirus ( ... T cells expressing these TCRs were activated by HLA-A2-positive cells loaded with cognate peptide or cells that stably ... Experimantal design: T cell responses against MCV Tag epitopes were investigated by immunizing transgenic mice that express a ...
Recent studies have suggested that since Merkel cell (primary cutaneous neuroendocrine) carcinomas are consistently CK20- ... The cases included 34 Merkel cell carcinomas and 89 small cell carcinomas from various sites (pulmonary, 37; gastrointestinal ... carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites Am J Surg Pathol. 1997 Feb;21(2 ... and Merkel cell. Recent studies have suggested that since Merkel cell (primary cutaneous neuroendocrine) carcinomas are ...
Merkel cell carcinoma is a rare but fast -growing form of skin cancer that tends to spread quickly. ... Merkel Cell Carcinoma What is Merkel cell carcinoma?. Merkel cell carcinoma is a rare but fast -growing form of skin cancer ... Merkel cell carcinoma is usually identified as a fast-growing nodule on the skin that is either skin-colored or can be reddish ... Diagnosis of Merkel cell carcinoma involves physical exam and skin biopsy. In addition, one or more of the following tests may ...
... with metastatic Merkel cell carcinoma (mMCC). In: Annals of Oncology. 43rd ESMO Congress (ESMO 2018), 19-23 Oct 2018, Munich, ... Cost-effectiveness (CE) of avelumab vs standard care (SC) for the treatment of patients (pts) with metastatic Merkel cell ...
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Treatment of Merkel Cell Carcinoma. Interview by. Aman Shah MD Interview with. Prof. Dr. Alexander C. J. van Akkooi MD, PhD ... Nivolumab and Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma Clin. Cancer Res ...
... presentation of Merkel cell carcinoma}, keyword = {breast cancer, Merkel cell carcinoma, in transit metastasis} } ... Merkel cell carcinoma/primary neuroendocrine tumour of the skin is a rare and aggressive type of carcinoma typically arising on ... In‐transit breast metastasis as the primary clinical presentation of Merkel cell carcinoma // The Breast Journal, 26 (2019), 5 ... In‐transit breast metastasis as the primary clinical presentation of Merkel cell carcinoma // The Breast Journal, 26 (2019), 5 ...
Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm; distant metastases are nearly always fatal. How ... Merkel Cell Carcinoma and Rare Appendageal Tumors * Oncology Case Challenge: A Construction Worker Who Drinks Daily Has an ... Fast Five Quiz: How Much Do You Know About Merkel Cell Carcinoma? - Medscape - May 31, 2017. ... Fast Five Quiz: How Much Do You Know About Merkel Cell Carcinoma? ...
Merkel cell expert Paul Nghiem, MD, PhD, explains how this rare but deadly condition differs from other forms of skin cancer. ... squamous cell carcinoma, basal cell carcinoma, or small cell lung cancer), but for patients who have developed distant ... Origin of Merkel Cell Carcinomas No Longer Murky * Epidemiology of Nonkeratinocytic Skin Cancers Among Persons With AIDS in the ... Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal neuroendocrine skin cancer. The incidence of MCC has been ...
... the term Merkel cell carcinoma is still most commonly used in view of the many similarities of the constituent tumor cell to ... Merkel cell carcinoma is a rare, aggressive, primary skin cancer exhibiting neuroendocrine differentiation. Several synonyms ... RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells. Oncotarget. 2016 May ... and immune status has shown that relative to virus-positive Merkel cell carcinomas, virus-negative Merkel cell carcinomas have ...
Rescue therapy for patients with anti-PD-1-refractory Merkel cell carcinoma: a multicenter, retrospective case series ... Rescue therapy for patients with anti-PD-1-refractory Merkel cell carcinoma: a multicenter, retrospective case series ...
Adjuvant Avelumab in Merkel Cell Carcinoma Trial * Surgically Treated Adjuvant Merkel Cell Carcinoma with Pembrolizumab (STAMP ... Adjuvant Avelumab in Merkel Cell Carcinoma Trial * Surgically Treated Adjuvant Merkel Cell Carcinoma with Pembrolizumab (STAMP ... Adjuvant Avelumab in Merkel Cell Carcinoma Trial. *Surgically Treated Adjuvant Merkel Cell Carcinoma with Pembrolizumab (STAMP ... LB1029: Correlation of merkel virus-specific CD8 T cells with response to immunotherapy in merkel cell carcinoma. * ...
  • Merkel cell carcinoma is the second most common cause of skin cancer death after melanoma . (cancer.gov)
  • The rate of recurrence of the rare but aggressive skin cancer Merkel cell carcinoma (MCC) is markedly higher than that for invasive melanoma, squamous cell carcinoma, or basal cell carcinoma, and more than half of all patients with stage IV disease will have a recurrence within 1 year of definitive therapy, results of a new study show. (medscape.com)
  • Nghiem and colleagues report that in contrast to patients with MCC, approximately 19% of patients with melanoma will have a recurrence, as will an estimated 5% to 9% of patients with squamous cell carcinoma and 1% to 10% of patients with basal cell carcinoma. (medscape.com)
  • This is a rare cancer of mostly older individuals with a lot of comorbidities, and also a cancer that, even though it is a primary cancer, might be detected a little later than even a melanoma primary tumor, just because of the nature of the neuroendocrine tumor cells," he said. (medscape.com)
  • MCC is sometimes mistaken for other histological types of cancer, including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. (wikipedia.org)
  • Other skin cancers, such as melanoma , basal cell carcinoma , or squamous cell carcinoma , are associated with an increased risk for Merkel cell carcinoma. (verywellhealth.com)
  • MCC is about 30 times less common than melanoma and far less common than basal or squamous cell carcinoma, and the clinical features of MCC are not extremely specific. (medscape.com)
  • The prognosis of Merkel cell carcinoma is worse than that of melanoma. (pediagenosis.com)
  • BACKGROUND: Merkel cell carcinoma (MCC) guidelines derive from melanoma and do not recommend baseline cross-sectional imaging for most patients. (pnlab.org)
  • Melanoma develops in skin melanocyte cells. (healthline.com)
  • Oncologists diagnose and treat cancers of the skin, including melanoma, basal cell carcinoma, and squamous cell carcinoma. (healthgrades.com)
  • Immunohistochemistry Immunohistochemistry was performed utilizing a tissues microarray for MCC, malignant basal and melanoma cell carcinoma. (saracatinib.info)
  • they are approved by the FDA for the treatment of patients with unresectable melanoma, as well as other cancers including non-small cell lung cancer (NSCLC), head and neck cancer, renal cell carcinoma (Opdivo), and Hodg kin lymphoma (Opdivo). (shu.edu)
  • Melanoma is a skin cancer type that begins in the pigment cells, called melanocytes. (roswellpark.org)
  • Melanoma is considered a more serious skin cancer type because it is more likely to spread than the much more common basal cell or squamous cell carcinomas. (roswellpark.org)
  • This is important because Merkel cancer is two to three times more likely to recur and to be fatal than melanoma," Dr. Paulson said in a statement . (newbeauty.com)
  • Melanoma is a dark-pigmented, usually malignant, tumor arising from a skin cell capable of making the pigment melanin (a melanocyte). (encyclopedia.com)
  • Non-melanoma skin cancer most often originates from the external skin surface as a squamous cell carcinoma or a basal cell carcinoma. (encyclopedia.com)
  • Phase II clinical trials are now underway to test the efficacy of ImmunoPulse on three rare skin cancers: metastatic melanoma, Merkel cell carcinoma, and cutaneous T-cell lymphoma. (zdnet.com)
  • During his residency he did a three year clinical research fellowship in Tumor Immunotherapy and Surgical Oncology in the Surgery Branch at the NCI/NIH, Bethesda MD. The focus of his research was on high dose Interleukin-2, tumor vaccines and cell based therapies for the treatment of metastatic melanoma. (rwjbh.org)
  • 2011 Durable and complete response for T cell transfer immunotherapy confirmed for patients with metastatic melanoma. (nih.gov)
  • 2011 Genetically engineered lymphocytes reactive with NY-ESO-1, a cancer/testis antigen, may cause tumor regression in patients with metastatic synovial cell sarcoma and melanoma. (nih.gov)
  • 1994 Patients with metastatic melanoma treated with cell therapy. (nih.gov)
  • Our clinical research program offers studies for patients with both early- and late-stage skin cancers, including melanoma, basal cell carcinoma, cutaneous squamous cell carcinoma and Merkel cell carcinoma. (hopkinsmedicine.org)
  • A main culprit in the development of melanoma and other skin cancers is the ability of cancerous cells to evade the body's natural defenses against foreign and diseased cells. (hopkinsmedicine.org)
  • Our scientists have performed first-of-its-kind research on inhibitory receptors such as PD-1 expressed by immune cells, which bind to molecules such as PD-L1 on melanoma or other kinds of cancer cells and shield them from the immune system. (hopkinsmedicine.org)
  • In collaboration with industrial partners, Johns Hopkins scientific and clinical researchers developed effective monoclonal antibody therapies to block these interactions in patients with advanced melanoma (nivolumab, Opdivo), Merkel cell carcinoma (pembrolizumab, Keytruda), and other cancer types, leading the Food and Drug Administration (FDA) to approve such therapies as new standards of care. (hopkinsmedicine.org)
  • Wide excision of the primary tumour bed following local excision of a primary melanoma, appendageal carcinoma, malignant connective tissue or merkel cell carcinoma of the skin may be claimed using item 31371, 31372, 31373, 31374, 31375 or 31376, depending on the location of the malignancy and the size of the excision diameter. (health.gov.au)
  • Melanoma forms in the layer of skin that houses pigmented cells. (dermasap.com)
  • The main classifications of skin cancers are melanoma and non-melanoma , the latter of which breaks down into Basal Cell Carcinomas (BCCs), Squamous Cell Carcinomas (SCCs) and Merkel Cell Carcinomas (MCCs). (lifejacketskin.com)
  • Melanoma arises in the pigment cells (the melanocytes). (lifejacketskin.com)
  • Skin-Cancer2020 follows the success of the 2019 Congress and will continue to review and focus on the recent advancements in the diagnosis, treatment and management of various skin cancers such as basal and squamous cell carcinomas, melanoma, merkel cell carcinoma, cutaneous lymphomas and other rare skin cancers. (skin-cancer2020.com)
  • Treatment of inguinal and axillary area for locally advanced malignant melanoma and Merkel cell carcinoma. (arkansasbluecross.com)
  • About three quarters of malignant non-melanoma skin cancers are basal cell carcinomas. (krebsdaten.de)
  • Squamous cell carcinomas account for almost a quarter of malignant non-melanoma skin tumours. (krebsdaten.de)
  • Rare forms of non-melanoma skin cancer include Merkel cell carcinomas, which are a form of neuroendocrine tumour, dermatofibrosarcoma and carcinomas of the sebaceous and sweat glands. (krebsdaten.de)
  • However, others have argued that MCC likely derives from an epithelial precursor cell due to its frequent presence in mixed tumors including epithelial neoplasms such as squamous cell carcinoma. (wikipedia.org)
  • We showed cytotoxic potential of T cells engineered to express these TCRs in vitro and demonstrated regression of established tumors in a mouse model upon TCR gene therapy. (mdc-berlin.de)
  • However, only limited numbers of these tumors have been studied, and the pattern of CK20 expression in other small cell carcinomas has not been established. (nih.gov)
  • Also see Merkel Cell Tumors of the Head and Neck and Merkel Cell Carcinoma and Rare Appendageal Tumors . (medscape.com)
  • This virus has been isolated from a high percentage of Merkel cell tumors, but not from all of them. (pediagenosis.com)
  • Glypican-3 (GPC3) is an oncofetal tumor antigen that is an attractive target for chimeric antigen receptor T cell therapy due to its highly restricted expression on normal tissue and high prevalence in several solid tumors. (labmedica.com)
  • Approximately 80% of the tumors are caused by Merkel cell polyomavirus (MCPyV), while the remaining are caused by UV-induced mutations in the DNA of the cell. (dataverse.no)
  • The approval was based on data from KEYNOTE-590 ( ClinicalTrials.gov , NCT03189719 ), a multicenter, randomized, placebo-controlled trial that enrolled 749 patients with metastatic or locally advanced esophageal or GEJ (tumors with epicenter 1 to 5 centimeters above the GEJ) carcinoma who were not candidates for surgical resection or definitive chemoradiation. (businesswire.com)
  • When the researchers tracked the cells in the patients' bodies, they saw that the immune cells traveled from the bloodstream, where they are administered, to the tumors. (newswise.com)
  • But for many cancer patients, especially patients with solid tumors like breast or lung cancer, the promise of T-cell therapy has yet to be delivered. (newswise.com)
  • The majority of Merkel cell carcinomas are caused by a nearly ubiquitous virus known as the Merkel cell polyomavirus, and most patients who have the disease have a high level of one of the virus' proteins present in their tumors - but nowhere else. (newswise.com)
  • In prior studies, scientists already noticed that in some patients Merkel cell tumors are overseen by the immune defense because they do no present human leukocyte antigens (HLA) on their cell surface. (dkfz.de)
  • DETECTing Merkel Cell Polyomavirus in Merkel Tumors. (ncbs.res.in)
  • A biotech start-up is combining immunotherapy with a novel approach to bolster your body's ability to naturally kill off cancer cells, using electricity to shock tumors. (zdnet.com)
  • Cancer immune reprogramming can be classified in three phases: (a) stimulation of adaptive and innate immune system to eradicate cancer cells (eradication phase), (b) survival of irregular malignant cells which can activate immune reprogramming (equipoise phase), (c) establishing immunosuppressive microenvironment and low-immunogenic tumors (escape phase) [ 7 , 8 ]. (springer.com)
  • Thymoma and Thymic Carcinoma: Affecting the thymus gland's epithelial cells, tumors form in six (sometimes seven) ways. (oncology-clinics.com)
  • Most cases of PCNSL have diffuse large B-cell lymphoma (DLBCL) histopathology, but PCNSL accounts for less than 3% of all primary tumors of the CNS and 1 to 2% of all NHLs [2-4]. (researchsquare.com)
  • Merkel cells display paranuclear staining for cytokeratins, which are also found in other neuroendocrine tumors. (medscape.com)
  • The virus, now named Merkel cell polyomavirus (MCV or MCPyV), was consistently found to be clonally integrated in 80% of MCC tumors. (medscape.com)
  • These precision nano-sized medicines aim to re-educate and harness patient T-cell response against tumors, leading to an immunological memory able to control tumor relapse without any follow-up treatment. (skin-cancer2020.com)
  • Immunocytochemical analysis of cell lines derived from solid tumors. (mpg.de)
  • ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma. (harvard.edu)
  • GlobalData also anticipates that the growth of the market share for the two anti-PD-L1 therapies will be accelerated by approvals in other oncology indications, specifically metastatic renal cell carcinoma (mRCC) and non-small cell lung cancer (NSCLC). (clinicaltrialsarena.com)
  • 2000 Nonmyeloablative allogeneic stem-cell transplantation can induce sustained regression of metastatic renal-cell carcinoma. (nih.gov)
  • KEYTRUDA is indicated for the adjuvant treatment of patients with renal cell carcinoma (RCC) at intermediate-high or high risk of recurrence following nephrectomy, or following nephrectomy and resection of metastatic lesions. (keytrudahcp.com)
  • Factors involved in the development of MCC include the Merkel cell polyomavirus (MCPyV or MCV), a weakened immune system, and exposure to ultraviolet radiation. (wikipedia.org)
  • with non-MCC high-grade neuroendocrine carcinomas (5 and Pierre Coursaget small-cell lung carcinomas and 3 well-differentiated in- testinal carcinomas) and an FFPE tissue specimen from a We investigated whether Merkel cell carcinoma (MCC) patient with high-grade neuroendocrine carcinoma of the patients in France carry Merkel cell polyomavirus (MCPyV) and then identified strain variations. (cdc.gov)
  • A new virus, Merkel frozen specimens, tissue was directly treated with protei- cell polyomavirus (MCPyV), recently was discovered in nase K and processed as above. (cdc.gov)
  • Overall, 65.9 percent of patients were PD-L1-positive and 52.3 percent were positive for the Merkel cell polyomavirus (MCPyV). (curetoday.com)
  • Feng et al established in 2008 that approximately 80% of Merkel cell carcinomas in the Northern hemisphere occur after genomic integration by a ubiquitous skin commensal virus, Merkel cell polyoma virus (MCPyV). (medscape.com)
  • Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma, which is an uncommon aggressive skin cancer, and trichodysplasia spinulosa-associated polyomavirus (TSPyV) is associated with trichodysplasia spinulosa, which is a rare skin disorder ( 1 - 3 ). (cdc.gov)
  • MCC is related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. (labmedica.com)
  • Immunostaining of Merkel cell polyomavirus-large T antigen (MCPyV-LT) showed a positive reaction and MCPyV-positive MCCs were assessed by PCR analysis, demonstrating that viral copy number was 12.8 copies per cell. (tottori-u.ac.jp)
  • This dataset is analyses of identified proteins between MCPyV-negative (MCC13, MCC26, and UISO) and -positive (MKL1, MKL2, MS1, and WaGa) MCC cell line. (dataverse.no)
  • To understand the underlying mechanisms of virus-independent and virus-dependent MCC, we compared the proteome of MCPyV-negative (MCC13, MCC26, and UISO) and MCPyV-positive (MKL-1, MKL-2, MS-1, and WaGa) MCC cell lines. (dataverse.no)
  • The viral oncoproteins large T- and small t-antigens were detected in the MCPyV-positive cells, but also in exosomes derived from these cells. (dataverse.no)
  • Moreover, our results suggest that exosomal transmission of MCPyV oncoproteins to recipient cells in the tumor microenvironment contributes to tumorigenesis. (dataverse.no)
  • Integration of the Merkel cell polyomavirus (MCPyV) is observed in about 80% of the cases, while the remaining 20% are related to UV exposure. (researchgate.net)
  • [ 4 ] Literature over the last several years has uncovered a strong association between MCC and a newly found polyomavirus (now named the Merkel cell polyomavirus, abbreviated MCV or MCPyV). (medscape.com)
  • It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. (wikipedia.org)
  • We conclude that CK20-positivity in a small cell carcinoma of uncertain origin strongly predicts a diagnosis of Merkel cell carcinoma, especially if the majority of tumor cells are positive. (nih.gov)
  • The frequent CK20 positivity observed in salivary gland small cell carcinomas in this series suggests that at least some of them may be more closely related biologically to Merkel cell carcinoma than to pulmonary-type small cell carcinoma. (nih.gov)
  • This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)
  • Merkel Cell Carcinoma (MCC) is a rare neuroendocrine tumor of the skin which has a histological appearance similar to small cell carcinoma of the lung. (ispub.com)
  • Our findings suggest an epidermal origin of MCC in this setting, and to our knowledge provide the first molecular evidence that intraepithelial squamous dysplasia may represent a direct precursor for small cell carcinoma. (nature.com)
  • DEK expression in Merkel cell carcinoma and small cell carcinoma. (duke.edu)
  • Due to the COVID-19 pandemic and Russia-Ukraine War Influence, the global market for Merkel Cell Carcinoma Therapeutics estimated at US$ million in the year 2022, is projected to reach a revised size of US$ million by 2028, growing at a CAGR of % during the forecast period 2022-2028. (rnrmarketresearch.com)
  • The USA market for Merkel Cell Carcinoma Therapeutics is estimated to increase from $ million in 2022 to reach $ million by 2028, at a CAGR of % during the forecast period of 2023 through 2028. (rnrmarketresearch.com)
  • Merkel Cell Carcinoma Market is expected to grow at a CAGR of 8.7% during the forecast period 2022-2029. (pressrelease.cc)
  • Merkel Cell Carcinoma Market was valued at US$ YY million in 2021 and is estimated to reach US$ YY million by 2029, growing at a CAGR of 8.7% during the forecast period (2022-2029). (pressrelease.cc)
  • 2022. Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin. . (ncbs.res.in)
  • Ce webinaire a passé en revue les dernières nouvelles, les points essentiels, les données cliniques et d'autres mises à jour présentées lors de l'assemblée annuelle de l'American Society of Clinical Oncology (ASCO) qui a eu lieu à Chicago, en Illinois, en juin 2022. (saveyourskin.ca)
  • The MCC incidence rate is on par with diseases including cutaneous T-cell lymphoma and dermatofibrosarcoma protuberans that are on the radar of dermatologists, study co-author and MCC specialist Paul Nghiem, MD, PhD, told MedPage Today. (medpagetoday.com)
  • Lymphoma is a disease of the lymphocytes, a type of white blood cell. (ohsu.edu)
  • Blood cancer specialists diagnose and treat cancers such as leukemia, lymphoma and myeloma that affect the blood cells, bone marrow, or lymphatic system. (healthgrades.com)
  • What differentiates Hodgkin's lymphoma is the presence of Reed-Sternberg cells in the cancerous tissue. (lymphomainfo.net)
  • The presence of these cells, detectable only through an open biopsy, is the defining characteristic of Hodgkin's disease, as opposed to non-Hodgkin's lymphoma. (lymphomainfo.net)
  • Approximately 7% of patients with non-small cell lung cancer (NSCLC) possess a transgene that results from an inversion of chromosome 2 that juxtaposes the 5' end of the echinoderm microtubule-associated protein-like 4 ( EML4 ) gene with the 3′ end of the anaplastic lymphoma kinase ( ALK ) gene, resulting in the novel fusion oncogene EML4-ALK . (shu.edu)
  • Cutaneous T-cell lymphoma is cancer that affects a type of white blood cell called T cells, which help fight infection and other diseases. (roswellpark.org)
  • Cutaneous T-cell lymphoma often appears as a rash on the skin and may be mistaken for eczema or psoriasis. (roswellpark.org)
  • Minimal residual disease in patients with diffuse large B-cell lymphoma undergoing autologous stem cell transplantation. (dana-farber.org)
  • Michael Girardi, MD, is the director of Yale Medicine Dermatology's ECP (Photopheresis) Immunotherapy Program, which is internationally recognized for developing the immunotherapy treatment photopheresis for advanced cutaneous T-cell lymphoma, graft-versus host disease and organ transplant rejection. (yalemedicine.org)
  • Efficacy and Safety of Topical Hypericin Photodynamic Therapy for Early-Stage Cutaneous T-Cell Lymphoma (Mycosis Fungoides): The FLASH Phase 3 Randomized Clinical Trial. (yalemedicine.org)
  • 2015 Discovery of a more sensitive biomarker to predict relapse in patients with diffuse large B-cell lymphoma. (nih.gov)
  • Dr. Kenneth Kaushansky speaks about clinical trials to treat patients with T-cell acute lymphoblastic leukemia and T-cell lymphoma at Stony Brook University Hospital. (newsday.com)
  • Methods Sixty-eight patients with newly diagnosed PCNSL had diffuse large B-cell lymphoma and were treated with high-dose methotrexate-containing chemotherapy. (researchsquare.com)
  • Alectinib for treatment of anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer, as detected by an FDA-approved test. (mdlinx.com)
  • For negative in situ hybridization controls, we used tissue specimens from patients with Merkel cell polyomavirus-positive Merkel cell carcinoma and BK polyomavirus nephropathy and a T-cell lymphoma tissue microarray that included 1 case of Merkel cell polyomavirus-positive T-cell lymphoma. (cdc.gov)
  • Merkel cell carcinoma is a very rare disease in which malignant (cancer) cells form in the skin. (cancer.gov)
  • Merkel cell carcinoma , also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when Merkel cells grow out of control. (cancer.gov)
  • The removal of skin cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (cancer.gov)
  • After Merkel cell carcinoma has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body. (cancer.gov)
  • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer occurring in about 3 people per 1,000,000 members of the population. (wikipedia.org)
  • Merkel cell carcinoma (MCC) is a rare, but fast-growing type of skin cancer that begins in the top layer of the skin, near nerve endings. (verywellhealth.com)
  • Because the virus is common and Merkel cell carcinoma is rare, experts say these other factors must contribute to the development of this cancer. (verywellhealth.com)
  • Merkel cell polyomavirus, which was discovered in 2008, lives in the skin of most people without developing into cancer. (verywellhealth.com)
  • Today's approval of avelumab ( Bavencio , EMD Serono) by the US Food and Drug Administration (FDA) is the first for a treatment of Merkel cell carcinoma (MCC), a rare and aggressive form of skin cancer. (medscape.com)
  • While skin cancer is one of the most common cancers, patients with a rare form called Merkel cell cancer have not had an approved treatment option until now," said Richard Pazdur, MD, acting director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research and director of the FDA's Oncology Center of Excellence. (medscape.com)
  • They explained that large, randomized studies in this patient population are difficult because Merkel cell carcinoma - an aggressive form of skin cancer - is a rare disease that has a rapid natural history and generally occurs in patients with substantial comorbidities. (medscape.com)
  • Although there are several Merkel cell carcinoma risk factors associated with this relatively rare form of skin cancer, it is impossible to predict with certainty whether or not a person will develop Merkel cell carcinoma. (moffitt.org)
  • Previous skin cancer diagnosis - Those who have been previously diagnosed with skin cancer are at a heightened risk of developing Merkel cell carcinoma. (moffitt.org)
  • Weakened immune system - Since the body's immune system helps to fight viruses and diseases, including cancer, those with weakened immune systems from certain drugs, lymphomas or other factors, may be at a higher risk for developing Merkel cell carcinoma. (moffitt.org)
  • At Moffitt Cancer Center, located just across the bridge from St. Petersburg, FL, in nearby Tampa, more about Merkel cell carcinoma risk factors is being discovered every day. (moffitt.org)
  • Moffitt has been named a Comprehensive Cancer Center by the National Cancer Institute, a designation that speaks directly to our commitment to advancing Merkel cell carcinoma research and treatment. (moffitt.org)
  • As the incidence of merkel cell carcinoma (MCC) rises, experts say early detection and optimal management with novel treatments will be crucial to improving outcomes for patients with this challenging and sometimes deadly neuroendocrine skin cancer. (medpagetoday.com)
  • Merkel Cell Carcinoma (MCC) is a rare, aggressive type of skin cancer. (outsourcestrategies.com)
  • Merkel cell carcinoma is a rare but fast -growing form of skin cancer that tends to spread quickly. (dartmouth.edu)
  • Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal neuroendocrine skin cancer. (medscape.com)
  • Merkel cell carcinoma Merkel cell carcinoma A skin cancer composed of cells that look microscopically similar to normal Merkel cells present in the skin. (parallelpublicworks.com)
  • The system was based on an analysis of over 5000 patients using the National Cancer Cancer A term used to describe diseases in which abnormal cells continually divide without normal regulation. (parallelpublicworks.com)
  • Merkel cell carcinoma: This rare skin cancer can appear on the skin as a hard patch (1) or firm bump (2). (nealderm.com)
  • Merkel cell carcinoma: This rare skin cancer most commonly looks like a shiny, dome-shaped growth that has visible blood vessels. (nealderm.com)
  • Had Merkel cell carcinoma (MCC) or another skin cancer. (nealderm.com)
  • Merkel cell carcinoma (MCC) is a rare aggressive skin cancer with neuroendocrine differentiation. (scilifelab.se)
  • The two most common types are basal cell cancer and squamous cell cancer. (medlineplus.gov)
  • If not treated, some types of skin cancer cells can spread to other tissues and organs. (medlineplus.gov)
  • PDT uses a drug and a type of laser light to kill cancer cells. (medlineplus.gov)
  • Merkel cell carcinoma (MCC) is a highly aggressive and often fatal neuroendocrine skin cancer linked to viral infection and excessive sun exposure. (edu.au)
  • The natural history of this disease is similar to small cell lung cancer. (ispub.com)
  • Bladder cancer begins when cells in the urinary bladder start to grow uncontrollably. (businesswire.com)
  • As more cancer cells develop, they can form a tumor and spread to other areas of the body. (businesswire.com)
  • Urothelial carcinoma, the most common type of bladder cancer, starts in the urothelial cells that line the inside of the bladder. (businesswire.com)
  • Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer mostly occurring in elderly patients, with increased incidence in case of immunosuppression. (labmedica.com)
  • Tissue microarray (TMA) slides or whole mount slides containing tumor samples from hepatocellular carcinoma (HCC), liposarcoma, lung cancer, and MCC patients were stained by GPC3 IHC assays using either GC33 or previously validated 1G12 antibody clones. (labmedica.com)
  • New codes (209.31-36 and 209.75) were added to describe Merkel cell carcinoma, a lethal skin cancer with a 33 percent mortality rate. (ahima.org)
  • Hyperkalemia, hyperphosphatemia, hyperuricemia, hypocalemia, and acute renal failure are caused by the breakdown products of dying cancer cells, which can occur even without cancer treatment. (ahima.org)
  • Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common types of skin cancer. (uamshealth.com)
  • Merkel cell carcinoma is a rare type of skin cancer that usually starts in areas of skin exposed to the sun. (uamshealth.com)
  • Keratinocyte cancer develops in skin cells called keratinocytes. (healthline.com)
  • In a clinical trial of the immunotherapy drug pembrolizumab, half of 25 patients with a rare type of virus-linked skin cancer called Merkel cell carcinoma experienced substantial tumor shrinkage lasting nearly three times as long, on average, than with conventional chemotherapy. (hopkinsmedicine.org)
  • Investigators at eight medical centers across the U.S., including the Johns Hopkins Kimmel Cancer Center and the Fred Hutchinson Cancer Research Center, enrolled 26 patients with metastatic or recurrent Merkel cell carcinoma who had not previously received any systemic therapies for advanced disease. (hopkinsmedicine.org)
  • Merkel cell carcinoma (MCC) is an unprecedented, competitive pore and skin cancer associated with an excessive threat of ordinary and spreading at some stage in the body. (pressrelease.cc)
  • The National Cancer Institute has also started a medical trial related to the investigational examine of the drug ipilimumab Theatic Merkel mobile carcinoma. (pressrelease.cc)
  • Merkel cell carcinoma (MCC) is an aggressive type of cutaneous cancer that affects mostly elderly people. (dataverse.no)
  • Merkel cell carcinoma, also known as endocrine carcinoma of the skin, is a recently recognized and particularly aggressive form of skin cancer that exhibits histologic features similar to those of endocrine malignant neoplasms arising from other tissues. (jamanetwork.com)
  • Interview with Paul Nghiem, MD, PhD, author of Recurrence and Mortality Risk of Merkel Cell Carcinoma by Cancer Stage and Time From Diagnosis . (iheart.com)
  • To better understand the relationship between these distinct tumor cell populations, we evaluated 7 pairs of MCC-SCCIS for overlapping genomic alterations by cancer profiling panel. (nature.com)
  • Merkel Cell Carcinoma (MCC) is a very rare and aggressive skin cancer that usually develops when a person is in his or her 70s. (lymphomainfo.net)
  • Their reasoning is that basal cell cancer is unlikely to be dangerous. (everydayhealth.com)
  • Next, the physician cauterizes the site of the tumor with a small device called an electrocautery needle, which stops the bleeding and destroys any stray cancer cells. (everydayhealth.com)
  • While the patient waits, the sample is examined under a microscope to see if there are any cancer cells. (everydayhealth.com)
  • The physician closes the incision with sutures, then sends the tissue specimen to a laboratory to veri f y that the border of healthy skin removed (known as the margin) does not, in fact, contain any cancer cells. (everydayhealth.com)
  • Which hormone or hormones the cancer cells secrete depends on where the cancer develops. (cancercenter.com)
  • This corresponds to the grade, or how different the cancer cells appear compared with normal cells. (cancercenter.com)
  • Lung NETs also may be classified as small cell neuroendocrine carcinoma, more often called small cell lung cancer. (cancercenter.com)
  • Large cell neuroendocrine carcinoma, a type of non-small cell lung cancer, is another form of lung NET. (cancercenter.com)
  • It tends to grow quickly and, despite its name, is quite similar to small cell lung cancer. (cancercenter.com)
  • Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably . (bristolcancerhelp.org)
  • in almost every case, treatment is required to destroy the cancer cells. (bristolcancerhelp.org)
  • That's because cancer cells do not function the way normal cells do. (bristolcancerhelp.org)
  • This treatment works by "training" your immune system to recognize and rid the body of cancer cells. (lvhn.org)
  • Dr. Shuda and his colleagues showed that a well-known cancer protein called mTOR, previously thought to be solely responsible for controlling a form of protein production important in cancer cells, called cap-dependent translation, can actually hand its work off to a different protein, CDK1, when cells are dividing. (upmc.com)
  • They observed the process while examining a viral oncoprotein that allows a common and usually harmless virus to transform healthy cells into cancer cells. (upmc.com)
  • Merkel cell polyomavirus (MCV) was discovered in 2008 by co-authors Yuan Chang, M.D. , and Patrick S. Moore, M.D., M.P.H. , in the Cancer Virology Program at UPCI, partner with UPMC CancerCenter . (upmc.com)
  • It causes a rare but deadly skin cancer called Merkel cell carcinoma. (upmc.com)
  • But it does point toward a fundamental control mechanism in cell biology and leads to the interesting possibility that creating or combining cancer drugs, so that they inhibit both mTOR- and CDK1-related protein synthesis, could be a very useful therapy to pursue. (upmc.com)
  • Like all cancers, skin cancer begins in the body's cells. (roswellpark.org)
  • Basal cell carcinoma is the most common skin cancer. (roswellpark.org)
  • Squamous cell carcinoma is a cancer that also begins in keratinocytes, squamous cells are the most abundant cells of the skin. (roswellpark.org)
  • Squamous cell cancer is the second most common type of skin cancer and some squamous cell carcinomas can spread to lymph nodes and other parts of the body. (roswellpark.org)
  • Merkel cell carcinoma is a rare, aggressive cancer that begins in the Merkel cells that are found among the basal cells in the deepest part of the epidermis layer. (roswellpark.org)
  • Sebaceous carcinoma is a cancer that begins in an oil gland of the skin, most commonly on the eyelid. (roswellpark.org)
  • Microcystic adnexal carcinoma is a cancer that begins in the sweat gland ducts, often on the face or other parts of the head or neck region. (roswellpark.org)
  • The overall survival findings from KEYNOTE-189 and KEYNOTE-407 changed the way patients with metastatic non-small cell lung cancer were treated and established KEYTRUDA plus chemotherapy as a foundational first-line treatment for this devastating disease," said Dr. (ft.com)
  • These results show meaningful improvements in five-year survival for patients receiving KEYTRUDA plus chemotherapy and reinforce the important role of these KEYTRUDA-based regimens as standards of care for metastatic non-small cell lung cancer. (ft.com)
  • Presented at the American Academy of Dermatology's (AAD) annual meeting last weekend, the study analyzed all skin cancer cases between 2000 and 2013, which revealed the dramatic increase in Merkel cell cancer, a particularly deadly type of the disease. (newbeauty.com)
  • And physicians' awareness and education on Merkel cancer and how to manage has been very limited. (newbeauty.com)
  • Chicago dermatologist Dr. Quenby Erickson says Merkel cell carcinoma is a very rare, but very aggressive form of skin cancer that typically arrises on sun-exposed skin . (newbeauty.com)
  • Dr. Erickson says, "There is no understanding of why this cancer is on the rise, however, it likely has something to do with the combination of an aging population-most Merkel cases develop in people age 50 and older-and their lifetime exposure to sun. (newbeauty.com)
  • Newswise - SEATTLE - May 30, 2017 - Three out of four patients treated with an experimental combination of three different therapies for the rare skin cancer known as Merkel cell carcinoma are in complete remission following the treatment, according to study results from a small clinical trial led at Fred Hutchinson Cancer Research Center . (newswise.com)
  • three of them are now in what's known as complete remission, where biopsies of their tumor sites show no evidence of remaining cancer cells. (newswise.com)
  • T-cell therapy - a form of immunotherapy that manipulates a patient's own immune cells in the lab to better fight their cancer - is showing promise for certain cancers, primarily blood cancers. (newswise.com)
  • Unlike some other forms of T-cell therapy such as CAR T-cell therapy, in which T cells are engineered in the lab to better recognize cancer cells, this approach uses laboratory manipulations to boost a patient's own response to their cancer. (newswise.com)
  • Various immunotherapeutic approaches are also being used to treat Merkel cell carcinoma, a rare type of skin cancer that is particularly aggressive. (dkfz.de)
  • The cause for this is to be found in the molecular makeup of the immune system and in the way cancer cells manipulate it. (dkfz.de)
  • The HLA system plays a key role in humans for the process of labeling cancer cells for destruction by immune cells. (dkfz.de)
  • In the present study, scientists from the German Caner Consortium (DKTK) at Essen University Hospital have been the first to discover the mechanisms that the cancer cells use for their camouflage. (dkfz.de)
  • The majority of Merkel cell carcinomas in Europe are caused by infection with the Merkel cell polyoma virus, which strongly manipulates the epigenetics of tumor cells, said Professor J rgen Becker, who is last author of the study and head of the DKTK working group Translational Skin Cancer Research at Essen University Hospital. (dkfz.de)
  • An important chemical label, the histone acetylation, is removed in the reprogrammed cancer cells. (dkfz.de)
  • Genes that are involved in the presentation of tumor antigens on the surface of cancer cells are thus being silenced, and the immune system no longer recognizes the tumor cells. (dkfz.de)
  • One is to equip the cancer cells with the missing processed antigens. (dkfz.de)
  • The cancer cells subsequently present them on their surface and are attacked and destroyed by T cells. (dkfz.de)
  • Bavencio is the first CPI immunotherapy approved for metastatic Merkel Cell Carcinoma ( McC ), a rare skin cancer affecting 1,500 people in the US each year. (clinicaltrialsarena.com)
  • The diagnosis caught everyone off guard: a rare and aggressive skin cancer known as Merkel cell carcinoma. (cancer.org.au)
  • A SUV39H1-low chromatin state characterises and promotes migratory properties of cervical cancer cells. (ncbs.res.in)
  • 2017. Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer. . (ncbs.res.in)
  • CD66 and CD49f expressing cells are associated with distinct neoplastic phenotypes and progression in human cervical cancer. (ncbs.res.in)
  • Keytruda is already an established treatment option for non-small cell lung cancer, and today's approval in small cell lung cancer demonstrates our commitment to bringing forward new treatment options for patients with advanced, difficult-to-treat cancers," said Dr. Jonathan Cheng, vice president, oncology clinical research, Merck Research Laboratories. (drugs.com)
  • We look forward to continuing to advance important clinical research in small cell lung cancer. (drugs.com)
  • Small cell lung cancer, which accounts for 10 to 15% of all lung cancers, is often diagnosed at an advanced stage where the prognosis is very poor and there have historically been limited treatment options," said Dr. Patrick Ott, MD, PhD, clinical director, Center for Immuno-Oncology, Dana-Farber Cancer Institute. (drugs.com)
  • The approval of Keytruda in small cell lung cancer provides an additional treatment option for patients based on the clinical response rates from KEYNOTE-158 and KEYNOTE-028. (drugs.com)
  • Skin cancer is the growth of abnormal cells capable of invading and destroying other associated skin cells. (encyclopedia.com)
  • Keytruda is a checkpoint inhibitor - a tumor-targeting drug that blocks the PD-1 arm on healthy cells from linking up with a partner arm on the surface of cancer cells to spread the disease. (spglobal.com)
  • Merkel cell carcinoma is an aggressive and rare form of skin cancer that is caused by a Merkel cell associated polyomavirus. (spglobal.com)
  • The company has developed "ImmunoPulse," a method of using an electric field to bind a gene-based immune trigger with cancer cells so that the body can produce a systemic response against a tumor. (zdnet.com)
  • 2017 A new immunotherapy for Merkel cell carcinoma, a rare type of skin cancer. (nih.gov)
  • 2005 Novel mutations in the fumarate hydratase gene in families with hereditary leiomyomatosis and renal cell cancer. (nih.gov)
  • Olson Grade, Need for More Treatment Are Markers of Increased Skin Cancer Risk in Actinic Keratoses In patients with multiple actinic keratoses, Olson grade III and the need for more treatment were identified as markers for increased risk of cutaneous squamous cell carcinoma in a secondary analysis of a randomized trial. (medscape.com)
  • The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. (springer.com)
  • Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. (springer.com)
  • This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus. (springer.com)
  • While these approaches have proven successful in reducing tumor burden and destroying cancer cells, they come with harsh side effects and high chances of recurrence [ 2 ]. (springer.com)
  • It can either aim to directly activate the immune system to fight against the cancer cells or may augment general immune responses. (springer.com)
  • In fact, Adoptive cell therapy (ACT) is a promising approach that involves the intervention of the patient's immune system to fight against cancer/tumor cells. (springer.com)
  • NK cells, for instance, can bind cancer cells, and several ACT approaches have been developed using this method, for example: Natural Killer Cell Therapy, other include Tumor-Infiltrating Lymphocyte Therapy (TILT), Engineered T-Cell Receptor Therapy (ETCR), Chimeric Antigen Receptor T-Cell Therapy (CARTCT). (springer.com)
  • Doctors diagnosed Winkle with Merkel cell carcinoma , a rare skin cancer, in August 2012. (fredhutch.org)
  • In 2014, a doctor gave her six months to live after she was diagnosed with Merkel cell carcinoma, a rare form of skin cancer that had spread to her organs. (newsday.com)
  • Avelumab, which is marketed as Bavencio, was granted accelerated approval by the U.S. Food and Drug Administration to treat metastatic Merkel cell carcinoma, a rare and aggressive skin cancer, and urothelial carcinoma, type of bladder cancer. (marketwatch.com)
  • Johns Hopkins scientists have pioneered ways to educate the immune system to detect, find and destroy skin cancer cells, by arming T lymphocytes with specific capabilities. (hopkinsmedicine.org)
  • Such interactions restrain anti-tumor immunity, allowing cancer cells to survive and spread. (hopkinsmedicine.org)
  • Carcinoma is a type of cancer that affects and starts in epithelial cells, typically these cells make up the skin and several internal organs. (oncology-clinics.com)
  • Carcinomas are very common ( breast cancer ), but have a few rare forms as well (merkel-cell). (oncology-clinics.com)
  • A carcinoma is like any other form of cancer, it involves the uncontrolled, ungoverned and potential spreading of cells. (oncology-clinics.com)
  • As you can see, these hard working cells are involved in nearly every bodily function, so a cancer in this area could be catastrophic. (oncology-clinics.com)
  • A common form of skin cancer effecting the top layer of skin known as the epidermis, which is made from squamous cells. (oncology-clinics.com)
  • A sister skin cancer to squamous cell, basal cells sit just below squamous cells in the epidermis. (oncology-clinics.com)
  • If the cancer affects the mucus glands of the ducts, the name is then adenocarcinoma (carcinoma of glands). (oncology-clinics.com)
  • Also referred to as intraductal carcinoma, DCIS is a form of non-invasive breast cancer. (oncology-clinics.com)
  • Sometimes called neuroendocrine carcinoma is rare form of skin cancer in which neuroendocrine cells (Merkel cells, part of nerve processes) are affected. (oncology-clinics.com)
  • Bladder cancer is the eleventh most common cancer in the UK, with urothelial carcinoma being the most common type of bladder cancer, accounting for 90 percent of all cases. (pharmiweb.com)
  • Extensive exploration of the role of the microbiome in cancer evolution has demonstrated that while the microbiome can affect cancer cells themselves, it can also modulate the cancer immunosurveillance. (frontiersin.org)
  • Merkel cell carcinoma (MCC) is an unusual and highly aggressive skin cancer and often appears in the elderly population. (medscape.com)
  • Like any cancer, uncontrolled cell replication characterizes skin cancer. (dermasap.com)
  • Past director of an active research laboratory which developed new cancer vaccines capable of stimulating the immune system to identify and eliminate cancer cells. (complexsurgicaloncology.com)
  • New indications were announced for checkpoint inhibitors, including for pretreated metastatic cancers with high levels of microsatellite instability and cancers with limited treatment options, such as gastric cancer, hepatocellular cancer, and Merkel cell carcinoma. (mdlinx.com)
  • Merkel Cell Carcinomas (MCCs) are a very rare but aggressive form of skin cancer associated with the Merkel cell polyomavirus virus. (lifejacketskin.com)
  • 1. Concomitant seminal vesicle invasion (cSVI) in patients with urothelial carcinoma of the bladder (UCB) and prostatic stromal infiltration was associated with decreased cancer-specific and overall survival rates. (2minutemedicine.com)
  • Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner. (mrmed.in)
  • This mechanism enables the activation of T-cell (immune cell) mediated immune response against cancer cells and prevents cancer growth. (mrmed.in)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Radiation therapy is used to kill mesothelioma cancer cells and provide palliative relief Learn about the benefits of radiation and possible side effects. (josephtartakovsky.com)
  • Additionally, skin cancer surveillance is very important to us, and we surgically remove skin cancers, such as squamous cell carcinoma and basal cell carcinoma. (summitmddermatology.com)
  • Squamous cell carcinoma is a type of skin cancer that affects the top layers of skin. (moffitt.org)
  • Residents of Tampa, Florida, who are in need of squamous cell carcinoma diagnostic or treatment services can turn to Moffitt Cancer Center. (moffitt.org)
  • Individuals with squamous cell carcinoma receive the services they need from a multispecialty team of dermatologists, surgical oncologists, dermatopathologists, plastic surgeons and many other cancer experts that make up our Cutaneous Oncology Program. (moffitt.org)
  • Individuals in Tampa, FL, who would like to discuss squamous cell carcinoma with one of our skin cancer experts can call 1-888-663-3488 or fill out a new patient registration form online. (moffitt.org)
  • Persons who have already had a basal cell carcinoma or squamous cell carcinoma have an increased risk of developing that type of skin cancer again. (krebsdaten.de)
  • The Skin Cancer Foundation was founded in 1979 and ever since they have been projecting ways to keep your skin safe and prevent cancerous cells from forming. (scottlovelandinsurance.com)
  • The most common type of skin cancer is the basal cell carcinoma and it is more likely to develop in areas of skin that receive the most sun exposure. (scottlovelandinsurance.com)
  • The best way to prevent the recurrent type is to protect the areas where the original cancer cell was. (scottlovelandinsurance.com)
  • Avelumab is a novel immunotherapy that acts an inhibitor of the programmed cell death (PD) pathway. (medscape.com)
  • Abstract #292: Is it safe to discontinue immunotherapy after a response in merkel cell carcinoma? (merkelcell.org)
  • Our laboratory is involved with a prospective clinical trial - TarGeted THerapy and Avelumab in Merkel Cell Carcinoma (GoTHAM) - involving the treatment of patients with a combination of radiation (peptide receptor radionuclide or external beam) and immunotherapy. (edu.au)
  • Predictors of immunotherapy benefit in Merkel cell carcinoma. (wjgnet.com)
  • Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma. (harvard.edu)
  • Avelumab is the first immunotherapy to demonstrate in a clinical trial a statistically significant improvement in overall survival as a first-line treatment for patients with advanced urothelial carcinoma. (pharmiweb.com)
  • Merkel cell carcinoma is an uncommonly encountered neuroendocrine malignant skin tumor that has an aggressive behavior. (pediagenosis.com)
  • Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor. (turkderm.org.tr)
  • Contrary to our expectation, malignant cells were not detected in the right palatine tonsil and right thyroid. (tottori-u.ac.jp)
  • Comparing the proteome of normal cells with diseased (malignant and other pathological conditions) or pathogen-infected cells allows identification of proteins and processes involved in the disease and recognition of possible biomarkers and targets for treatment. (dataverse.no)
  • Whilst SLAM-F7 is expressed on malignant plasma cells, it is also expressed on NK, T and B cells, dendritic cells and monocytes. (petermac.org)
  • It is not known whether all SLAM-F7+ immune subsets are targets for the Elo+Len effect or just the malignant plasma cells. (petermac.org)
  • Launch Merkel cell carcinoma (MCC) is certainly a very intense malignant epidermis tumor. (saracatinib.info)
  • Certainly, it comes with an important effect on apoptosis, proliferation, cell development and malignant change. (saracatinib.info)
  • Hodgkin's Disease is a malignant (cancerous) growth of cells in the lymphatic system . (lymphomainfo.net)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Squamous cell carcinoma is a malignant growth of the external surface of the skin. (encyclopedia.com)
  • squamous cell carcinomas account for about 95% of these cancers, with 3% being basal cell carcinomas and the remainder malignant melanomas. (encyclopedia.com)
  • It is postulated that these cells may acquire neuroendocrine features during malignant transformation. (medscape.com)
  • A primary malignant neoplasm of epithelial liver cells. (edu.au)
  • Merkel-cell cancers tend to invade locally, infiltrating the underlying subcutaneous fat, fascia, and muscle, and typically metastasize early in their natural history, most often to the regional lymph nodes. (wikipedia.org)
  • Finally, the presence of B-cell surface markers on MCC in addition to the high correlation between MCC and B-cell lymphomatous cancers have also led to suggestions that MCC may share a progenitor with B-cells. (wikipedia.org)
  • How Are Squamous and Basal Cell Skin Cancers Diagnosed? (medlineplus.gov)
  • What Will Happen After Treatment for Basal and Squamous Cell Skin Cancers? (medlineplus.gov)
  • What's New in Research and Treatment of Basal and Squamous Cell Skin Cancers? (medlineplus.gov)
  • Most are nonmelanoma skin cancers, usually basal cell carcinoma or squamous cell carcinoma. (ohsu.edu)
  • Basal and squamous cell carcinomas make up more than 95% of skin cancers. (ohsu.edu)
  • Basal cell cancers most often develop on areas with the most sun exposure, such as the face, head and neck. (ohsu.edu)
  • They often look like basal cell cancers but can also look like warts. (ohsu.edu)
  • Because NETs begin in certain cells that have properties of both endocrine and nerve cells, they're unique compared with other cancers. (cancercenter.com)
  • Less than 1 percent of cells are in the active division cycle called mitosis, even in very aggressive cancers, which makes studying cells in mitosis difficult. (upmc.com)
  • And if these stats are grimacing enough, a new report shows one of the rarer skin cancers, Merkel cell carcinoma, is on the rise. (newbeauty.com)
  • Research conducted at the University of Washington School of Medicine, led by the school's professor and chair of dermatology, Paul Ngheim, and student Kelly Paulson, a senior fellow in hematology and oncology, presents a scary finding: The number of U.S. cases of Merkel cell carcinoma is rising nearly six times faster than most other cancers. (newbeauty.com)
  • Merkel cell carcinoma is one of the deadliest skin cancers because it metastasizes when the primary tumor is still very small. (newbeauty.com)
  • Squamous cell cancers metastasize at a rate of 2 - 6%, with up to 10% of lesions affecting the ear and lip. (encyclopedia.com)
  • The U.S. regulator accepted the Kenilworth, N.J.-based company's supplemental biologics license application seeking accelerated approval for Keytruda for treating adults and children with Merkel cell carcinoma whose cancers have spread across the body. (spglobal.com)
  • Monoclonal antibody treatment, chimeric antigen receptor (CAR)-T cell therapy, and immune checkpoint inhibitors are the key immunotherapies that are being used against many cancers [ 3 , 4 ]. (springer.com)
  • Such treatments are now also available for patients with advanced basal and squamous cell cancers. (hopkinsmedicine.org)
  • As a group of cancers that affect the sinonasal tract, the most common is a form of squamous cell carcinoma, followed by an adenocarcinoma affecting the salivary glands. (oncology-clinics.com)
  • About 95 percent of nonmelanoma skin cancers are caused by exposure to UV rays that have resulted in damaged skin cells. (moffitt.org)
  • KEYNOTE-361 (ClinicalTrials.gov, NCT02853305 ) is a randomized, open-label, Phase 3 trial evaluating KEYTRUDA as monotherapy and in combination with chemotherapy versus chemotherapy alone, the current standard of care, for the first-line treatment of advanced or metastatic urothelial carcinoma. (businesswire.com)
  • Prognostic Value of HPV E6 and APOBEC3B in Upper Urinary Tract Urothelial Carcinoma. (nih.gov)
  • In addition, both Bavencio and Imfinzi received FDA approvals for the treatment of advanced urothelial carcinoma ( UC ) in 2017. (clinicaltrialsarena.com)
  • Merck and Pfizer announced today that the UK Medicines and Healthcare Products Regulatory Agency (MHRA) has issued an Early Access to Medicines Scheme (EAMS) positive scientific opinion for avelumab for the maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma that has not progressed with first-line platinum-containing chemotherapy. (pharmiweb.com)
  • Avelumab is now available in the UK through the EAMS scheme for the first-line maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma that has not progressed with first-line platinum-containing chemotherapy. (pharmiweb.com)
  • Avelumab is not licensed in the UK for locally advanced or metastatic urothelial carcinoma and a marketing authorisation application for this indication is currently under review by the European Medicines Agency (EMA). (pharmiweb.com)
  • Researchers have recently discovered that a common virus, called Merkel cell polyomavirus, plays a role in the development of many Merkel cell carcinoma cases. (verywellhealth.com)
  • Most Merkel cell carcinomas - approximately 80 percent - are caused by a virus called Merkel cell polyomavirus. (hopkinsmedicine.org)
  • Purpose: The causative agent of most cases of Merkel cell carcinoma (MCC) has been identified as the Merkel cell polyomavirus (MCV). (mdc-berlin.de)
  • The researchers used the approach to identify the viral integration sites of the Merkel cell polyomavirus in four FFPE cases of Merkel cell carcinoma, including one primary and subsequent metastatic tumor. (genomeweb.com)
  • Cite this: Avelumab: First Drug Ever Approved for Merkel Cell Carcinoma - Medscape - Mar 23, 2017. (medscape.com)
  • Bavencio (avelumab), a PD-L1-inhibitor, gained approval by the Food and Drug Administration (FDA) for some patients with Merkel cell carcinoma. (curetoday.com)
  • Bavencio (avelumab), a PD-L1-inhibitor, gained approval by the Food and Drug Administration (FDA) for the treatment of adult and pediatric patients over the age of 12 with metastatic Merkel cell carcinoma, including those who have never had chemotherapy. (curetoday.com)
  • EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) Injection 20 mg/mL, for intravenous use, for the treatment of adults and pediatric patients 12 years and older with metastatic Merkel cell carcinoma (mMCC). (pfizer.com)
  • Aim: To evaluate changes in health-related quality of life (HRQoL) in a Phase II trial (NCT02155647) of treatment-naive patients with metastatic Merkel cell carcinoma treated with avelumab (15-month follow-up). (pnlab.org)
  • Conclusion: These findings show unique longitudinal HRQoL data for treatment-naive metastatic Merkel cell carcinoma patients treated with avelumab. (pnlab.org)
  • Avelumab ( Bavencio) is a PD-L1 inhibitor that was approved for the treatment of patients with metastatic Merkel cell carcinoma (MCC). (shu.edu)
  • In their current study, the addition of avelumab seems to have kicked the T cells into high gear, Paulson said. (newswise.com)
  • Neoadjuvant nivolumab ( Opdivo , Bristol-Myers Squibb) could improve outcomes for patients with high-risk resectable Merkel cell carcinoma (MCC), say researchers reporting the first trial in this patient population. (medscape.com)
  • A Retrospective Study of Ipilimumab Plus Nivolumab in Anti-PD-L1/PD-1 Refractory Merkel Cell Carcinoma. (harvard.edu)
  • Indeed, nivolumab showed single-agent activity in relapsed and refractory PCNSL patients, and frequent copy-number alterations in 9p24.1/PD-L1/PD-L2 of tumor cells leading to the expression of PD-L1 and PD-L2 were found in PCNSL [17, 18]. (researchsquare.com)
  • Tumor cells have advanced beyond the original tumor and may have traveled as far as the nearby lymph nodes, but not beyond. (skincancer.org)
  • Tumor cells have spread to distant body areas, lymph nodes or organs. (skincancer.org)
  • Almost 100% of tumor cells were positive, except for two cases that showed staining of 10% and 30% of tumor cells, respectively. (nih.gov)
  • With immunohistochemistry, the tumor cells stain for both neuroendocrine (i.e., synaptophysin and chromogranin A) and epithelial markers. (scilifelab.se)
  • KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (businesswire.com)
  • KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (businesswire.com)
  • Multispectral immunofluorescence showing the interface between Merkel cell tumor cells (orange) and host immune cells (yellow marks CD8+ lymphocytes, red marks CD68+ macrophages). (hopkinsmedicine.org)
  • Cell-surface PD-L1 expression (green) is observed on macrophages, lymphocytes and tumor cells, adjacent to PD-1 expression (white) on lymphocytes. (hopkinsmedicine.org)
  • Histopathological examination revealed that most parts of the submandibular lymph node were occupied by diffuse sheets of tumor cells. (tottori-u.ac.jp)
  • Immunohistochemistry demonstrated a marked positive reaction for AE1/AE3, chromogranin A, synaptophysin, cytokeratin 20 (CK20) and CD56 and a negative reaction for vimentin, leucocyte common antigen (LCA), thyroid transcription factor-1 (TTF1) and cytokeratin 7 (CK7) in the tumor cells. (tottori-u.ac.jp)
  • DNA was isolated from cell lines and formalin-fixed paraffin-embedded tissue formulated with at R935788 least 60C80% of tumor cells using regular protocols. (saracatinib.info)
  • Such drugs consist in a monoclonal antibody linked to a cytotoxic agent, allowing a specific cytotoxicity to tumor cells. (researchgate.net)
  • That situation is an ideal setup for a working T-cell therapy, Paulson said, because therapeutic T cells need to recognize and attack tumor cells but spare healthy cells. (newswise.com)
  • If proper treatment is delayed and the tumor continues to grow, the tumor cells can spread, or metastasize, to other muscles, bones, nerves, and possibly to the brain. (encyclopedia.com)
  • After being cross primed by pAPC, naïve CTLs stimulate a cascade of events that results in CTL attack on tumor cells through granzymes or perforin and/or through ligands of tumor necrosis factor (TNF) superfamily [ 15 ]. (springer.com)
  • Background The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD-L1 (sPD-L1) from PD-L1 expressing tumor cells. (researchsquare.com)
  • PD-L1-positive tumor cells were found in 35 patients (67%), and the extent of PD-L1-postive tumor cells was positively associated with serum sPD-L1 levels ( r = 0.299, P = 0.031). (researchsquare.com)
  • Conclusions Serum levels of sPD-L1 could reflect the expression of PD-L1 in PCNSL tumor cells and predict patient survival outcomes. (researchsquare.com)
  • PD-1 is an inhibitory receptor expressed on activated T cells, and its interaction with PD-L1 suppresses T-cell mediated immune response allowing tumor cells to escape from anti-tumor immunity [16]. (researchsquare.com)
  • The microbiome affects tumor initiation and progression through direct effects on the tumor cells and indirectly through manipulation of the immune system. (frontiersin.org)
  • Recent evidences show that non-tumor cells within the tumor microenvironment (TME), including tumor vasculature and immune stromal cells, dictate the overall therapeutic efficacy. (skin-cancer2020.com)
  • Some experts, for instance, question the practice of aggressively screening and treating frail, elderly patients for basal cell carcinomas that aren't causing uncomfortable symptoms. (everydayhealth.com)
  • Basal cell carcinomas are typically slowly enlarging, pink, pearly bumps that bleed easily, but they may also present as slow growing painless ulcers. (roswellpark.org)
  • Basal Cell Carcinomas (BCCs) begin in the basal cells. (lifejacketskin.com)
  • Sun exposure and having a weak immune system can affect the risk of Merkel cell carcinoma. (cancer.gov)
  • You are more at risk for Merkel cell carcinoma if you have a weak immune system. (verywellhealth.com)
  • The most common serious risks are immune-mediated, wherein the body's immune system attacks healthy cells or organs, and may include pneumonitis, hepatitis, colitis, endocrinopathies, and nephritis. (medscape.com)
  • This is a tricky one because 92% of MCC patients are not immune compromised, but those with long-term T-cell dysfunction (organ transplant recipients, autoimmune disease patients receiving immune suppression, HIV patients, chronic lymphocytic leukemia patients) are at much higher risk of developing MCC, but they represent less than 10% of all cases. (medscape.com)
  • furthermore, mhTERThigh was strongly associated with older age (80.5 vs 72 years, p = 0.026), no angioinvasion (40.7% vs 71.0%, p = 0.015), lower Ki67 (50 vs 70%, p = 0.005), and PD-L1 expressions in both tumor (0 vs 3%, p = 0.021) and immune cells (0 vs 10%, p = 0.002). (unibo.it)
  • Immune-mediated adverse reactions can occur at any time during or after treatment with KEYTRUDA, including pneumonitis, colitis, hepatitis, endocrinopathies, nephritis, dermatologic reactions, solid organ transplant rejection, and complications of allogeneic hematopoietic stem cell transplantation. (businesswire.com)
  • Using an immune-competent mouse model this project will explore the role for CD4+ CAR-T cells in tumour clearance, CD8+ CAR-T cell persistence and whether increased numbers of CD4+ CAR-T cells play a role in CAR-T cell attack of normal tissue. (petermac.org)
  • Real-world outcomes treating patients with advanced cutaneous squamous cell carcinoma with immune checkpoint inhibitors (CPI). (harvard.edu)
  • Merkel cell carcinoma of the skin is often invisible for the body s immune defense because it silences specific genes of the immune system. (dkfz.de)
  • Immune-mediated adverse reactions, which may be severe or fatal, can occur with Keytruda, including pneumonitis, colitis, hepatitis, endocrinopathies, nephritis and renal dysfunction, severe skin reactions, solid organ transplant rejection and complications of allogeneic hematopoietic stem cell transplantation (HSCT). (drugs.com)
  • Basal cell and squamous cell carcinomas can grow more easily when people have a suppressed immune system because they are taking immunosuppressive drugs or are exposed to radiation. (encyclopedia.com)
  • The adaptive immune system comprises CD8 + cytotoxic T cells (CTLs), CD4 + helper T cells, and B cells [ 11 ]. (springer.com)
  • The innate immune system can regulate the adaptive immune system by secreting various signals to activate both T and B cells [ 12 ]. (springer.com)
  • A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. (edu.au)
  • Keytruda 100mg blocks the PD-1 receptor found on immune cells, preventing binding and activation of proteins PDL-1 and PDL-2. (mrmed.in)
  • J ü rgen C. Becker received his medical degree from the Medical School Hannover for his work on the immune regulatory capacity of natural killer cells on the adaptive immune system. (hpvconference2016.nl)
  • Interestingly, because aggressive NET cells are so different from normal cells, chemotherapy may be more successful against them. (cancercenter.com)
  • Salvage treatment options for relapsed/refractory PCNSL include high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) or WBRT [13-15]. (researchsquare.com)
  • Merkel cells are in the layer of basal cells at the deepest part of the epidermis and are connected to nerves. (cancer.gov)
  • Merkel cells are highly specialized cells that act as pressure receptors in the epidermis. (wikipedia.org)
  • [ 4 ] These specialized sensory cells are normally found in the basal epidermis of skin and parts of mucosal surfaces derived from the ectoderm. (medscape.com)
  • Within skin, Merkel cells have also been shown to cluster in the basal layers of the interfollicular epidermis in specialized epithelial structures called touch domes, where they are juxtaposed with epidermal keratinocytes. (medscape.com)
  • [ 6 ] As they are primarily postmitotic, Merkel cells putatively have low sensitivity to oncogenic stimuli, and they are found in the basal epidermis, whereas cutaneous neuroendocrine carcinomas arise in the dermis. (medscape.com)
  • This type starts in basal cells in the epidermis, the skin's top layer. (ohsu.edu)
  • This type grows in squamous cells in the epidermis. (ohsu.edu)
  • Squamous cells: Thin, flat cells that form the top layer of the epidermis. (uamshealth.com)
  • Melanocytes: Cells that make melanin and are found in the lower part of the epidermis. (uamshealth.com)
  • The epidermis is the outer surface of the skin and contains several major cell types - squamous cells which are also known as keratinocytes, pigment cells also known as melanocytes, Merkel cells and leukocytes. (roswellpark.org)
  • Merkel cells are nondendritic, nonkeratinocytic epithelial cells located primarily in or near the basal layer of the epidermis. (medscape.com)
  • For example, MCC develops almost exclusively in the dermis, whereas the overwhelming majority of Merkel cells are found in the epidermis, a site rarely involved with MCC. (medscape.com)
  • Keratinocytes are the main cells of the epidermis and are formed by cell division at its base. (lifejacketskin.com)
  • A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. (edu.au)
  • With this study, we aimed to isolate and characterize Tag-specific T cell receptors (TCR) for potential use in gene therapy clinical trials. (mdc-berlin.de)
  • Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. (nealderm.com)
  • We conclude that immunohistochemistry for SATB2 can be used as an additional marker with similar sensitivity and specificity as CK20 for the diagnosis of Merkel cell carcinoma, suggesting a clinical utility in difficult cases where MCC is suspected. (scilifelab.se)
  • The clinical differential diagnosis is often between Merkel cell carcinoma and basal cell carcinoma, inflamed cyst, squamous cell carcinoma, or an adnexal tumor. (pediagenosis.com)
  • Have you or a member of your immediate family benefited from a clinical trial or treatment using adult or cord blood stem cells? (stemcellresearch.org)
  • Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma. (harvard.edu)
  • Much of his work has focused on the clinical development of new therapeutic regimens in CLL utilizing combinations of targeted inhibitors of Bcl-2, B cell receptor pathway kinases, and other novel agents, as well as utilizing checkpoint blockade to enhance anti-tumor immunity in patients with hematologic malignancies who relapse post allogeneic hematopoietic cell transplantation. (dana-farber.org)
  • 2012 Good Manufacturing Practices for stored clinical bone marrow stromal cell products developed. (nih.gov)
  • Clinical practice guide - Basal cell carcinoma, squamous cell carcinoma(and related lesions)-a guide to clinical management in Australia. (health.gov.au)
  • Merkel cell carcinoma starts most often in areas of skin exposed to the sun, especially the head and neck, as well as the arms, legs, and trunk . (cancer.gov)
  • Forty-one patients with Merkel cell carcinoma arising from the cutaneous surfaces of the head and neck were seen at the University of Texas M. D. Anderson Hospital, Houston, between 1966 and 1983. (jamanetwork.com)
  • Goepfert H, Remmler D, Silva E, Wheeler B. Merkel Cell Carcinoma (Endocrine Carcinoma of the Skin) of the Head and Neck. (jamanetwork.com)
  • To evaluate the tumour response rate of squamous cell carcinoma of the head and neck following stereotactic body radiotherapy (SBRT) of 45Gy in 5 fractions delivered once every 3-4 days, such that treatment is completed within 15 days. (centerwatch.com)
  • With respect to squamous cell carcinoma (SCC) of the skin, there is limited evidence to guide treatment in patients with unresectable or medically inoperable disease, particularly in the head and neck region. (centerwatch.com)
  • The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (edu.au)
  • MCC occurs as a result of uncontrolled growth of cells that have some characteristics that are similar to the normal Merkel cells of the skin. (outsourcestrategies.com)
  • The normal Merkel cells function in mechanoreception of the skin. (pediagenosis.com)
  • Excessive exposure to ultraviolet light - Exposure to UV rays, most commonly from the sun or indoor tanning beds, can cause damage to the DNA in a person's skin cells, which may lead to the development of Merkel cell carcinoma. (moffitt.org)
  • The Merkel cell polyomavirus has been studied to assess its role in the development of Merkel cell carcinoma. (pediagenosis.com)
  • Researchers have implicated the Merkel cell polyomavirus as a potential cause of Merkel cell carcinoma. (pediagenosis.com)
  • It was only about five years ago that researchers discovered a virus to be the cause of Merkel cell carcinoma. (fredhutch.org)
  • Diagnosis of Merkel cell carcinoma involves physical exam and skin biopsy. (dartmouth.edu)
  • These histological findings confirmed the diagnosis of Merkel cell carcinoma of the lymph node. (tottori-u.ac.jp)
  • Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study. (medscape.com)
  • Today's approval of this indication for KEYTRUDA introduces a new option, which has shown a superior survival benefit compared to FU and cisplatin alone, for newly diagnosed patients with locally advanced or metastatic esophageal or GEJ carcinoma that is not amenable to surgical resection or definitive chemoradiation, regardless of PD-L1 expression status and tumor histology. (businesswire.com)
  • Merkel-cell carcinoma usually arises on the head, neck, and extremities, as well as in the perianal region and on the eyelid. (wikipedia.org)
  • Typically, the carcinoma appears on areas of the skin that are constantly exposed to the sun, such as the head/neck and arms. (outsourcestrategies.com)
  • C440 Skin of lip, NOS C442 External ear C443 Skin of other and unspecified parts of face C444 Skin of scalp and neck C445 Skin of trunk C446 Skin of upper limb and shoulder C447 Skin of lower limb and hip C448 Overlapping lesion of skin C449 Skin, NOS **Note 1:** This schema is based on the UICC chapter *Carcinoma of Skin,* pages 165-168. (cancer.gov)
  • Squamous cell carcinoma are cells that also develop in highly exposed areas (ears, neck, etc. (scottlovelandinsurance.com)
  • Plaza JA, Suster S. The Toker tumor: spectrum of morphologic features in primary neuroendocrine carcinomas of the skin (Merkel cell carcinoma). (medscape.com)
  • Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma, a dermal neoplasm with cytoplasmic, dense-core neuroendocrine granules and keratin filaments. (medscape.com)
  • Recent studies have suggested that since Merkel cell (primary cutaneous neuroendocrine) carcinomas are consistently CK20-positive, this feature may help to distinguish it from pulmonary small cell carcinomas. (nih.gov)
  • Merkel cell carcinoma/primary neuroendocrine tumour of the skin is a rare and aggressive type of carcinoma typically arising on the sun-exposed skin of elderly or immunosuppressed patients. (irb.hr)
  • We herein report the case of Merkel cell carcinoma of the breast located in the retroareolar region with an in-transit metastasis in a 79-year-old female, clinically mimicking a primary non- cutaneous breast tumour, while histologically mimicking a distant metastasis on needle core biopsy. (irb.hr)
  • Merkel cell carcinoma is a rare primary cutaneous neuroendocrine carcinoma with growing incidence and high metastatic potential. (medscape.com)
  • Surgery to remove the primary tumor is the maximum commonplace initial remedy for merkel mobile carcinoma. (pressrelease.cc)
  • Since then, it has been referred to as cutaneous neuroendocrine carcinoma, small cell tumor of the skin, primary undifferentiated carcinoma of the skin, anaplastic carcinoma of the skin, murky cell carcinoma, neuroendocrine tumor of the skin, or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties). (medscape.com)
  • MCC (Merkel cell carcinoma) is an aggressive neuroendocrine cutaneous neoplasm. (researchgate.net)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (edu.au)
  • In this report, we aimed to underline the importance of early diagnosis while presenting a case of giant Merkel cell carcinoma which shows an aggressive progression with lung metastases. (turkderm.org.tr)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • They create the structures of the lung, ducts and glands, form the skin, female reproductive system and act as sensory receptors, secretion sells, and even digestive absorption cells. (oncology-clinics.com)
  • Toker C. Trabecular carcinoma of the skin. (medscape.com)
  • [ 1 ] It was originally described by Cyril Toker in 1972 under the designation trabecular carcinoma of the skin. (medscape.com)
  • The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. (medscape.com)
  • This article will discuss the causes, symptoms, treatment, and outlook for Merkel cell carcinoma. (verywellhealth.com)
  • Patients with Merkel cellular carcinoma are commonly first treated with surgical treatment. (pressrelease.cc)
  • Association between treatment center experience and survival after diagnosis of stage I to III Merkel cell carcinoma treated with surgery with or without postoperative radiation therapy. (harvard.edu)
  • Indolent NET cells may not respond as well to treatment due to their similarity to normal cells. (cancercenter.com)
  • Merkel cell carcinoma metastasizes in a third of patients even with prior treatment, and when it does, it's often deadly - historical five-year survival rates for patients with metastatic disease are less than 10 percent. (newswise.com)
  • That study, known as JAVELIN Merkel 2000, was published online September 1, 2016, in Lancet Oncology, as previously reported by Medscape Medical News . (medscape.com)
  • The approval is based on data from the phase 2 JAVELIN Merkel 200 study, which was presented at the 2016 ASCO Annual Meeting and published in the Lancet Oncology . (curetoday.com)
  • The JAVELIN Merkel 200 study enrolled 88 previously treated patients with metastatic MCC. (curetoday.com)
  • Background: Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are rare, aggressive cutaneous T-cell lymphomas that may be difficult to treat. (researchgate.net)
  • While epithelial cells are not typically found in the dermis, hair follicles include epithelial cells that have been shown to have oncogenic potential, and have therefore been proposed as a possible site for a MCC precursor. (wikipedia.org)
  • Making up one of the four main types of tissue which comprise the human body (the others being muscle tissue, nervous tissue and connective tissue), epithelial cells are by far the most common of the four. (oncology-clinics.com)
  • A key characteristic of epithelial cells is their ability to form "sheets. (oncology-clinics.com)