A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Tumors or cancer of the LUNG.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Any chemical species which accepts an electron-pair from a LEWIS BASE in a chemical bonding reaction.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Pathological processes involving any part of the LUNG.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A cell line derived from cultured tumor cells.
Tumors or cancer of the LIVER.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent.
A malignant epithelial tumor with a glandular organization.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
The transference of either one or both of the lungs from one human or animal to another.
An inhibitor of nucleotide metabolism.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Tumors or cancer of the COLON.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC 2.4.1.65; EC 2.4.1.68; EC 2.4.1.69; EC 2.4.1.89.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the human BREAST.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the NASOPHARYNX.
Tumors or cancer of the THYROID GLAND.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Elements of limited time intervals, contributing to particular results or situations.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
A syndecan that is predominantly expressed during EMBRYONIC DEVELOPMENT. It may play a role in mediating cellular interactions with the EXTRACELLULAR MATRIX and may modulate the signaling activity of certain INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Circulating 38-kDa proteins that are internal peptide fragments of PLASMINOGEN. The name derives from the fact that they are potent ANGIOGENESIS INHIBITORS. Angiostatins contain four KRINGLE DOMAINS which are associated with their potent angiostatic activity.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Tumors or cancer of the ESOPHAGUS.
The only family of the buckwheat order (Polygonales) of dicotyledonous flowering plants. It has 40 genera of herbs, shrubs, and trees.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Adherence of cells to surfaces or to other cells.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Tumors or cancer of the MOUTH.
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumors escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies.
Transplantation between animals of different species.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Established cell cultures that have the potential to propagate indefinitely.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Experimentally induced tumors of the LIVER.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Medical treatment involving the use of controlled amounts of X-Rays.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
DNA present in neoplastic tissue.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Tumors or cancer of the SKIN.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Antibodies produced by a single clone of cells.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumors or cancer of the UTERINE CERVIX.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
An antimitotic agent with immunosuppressive properties.
Drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells.
Tumors or cancer of the gallbladder.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The action of a drug in promoting or enhancing the effectiveness of another drug.
Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.
An encapsulated lymphatic organ through which venous blood filters.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
RNA present in neoplastic tissue.
Proteins prepared by recombinant DNA technology.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Tumors or cancer of the SALIVARY GLANDS.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.

Successful adoptive immunotherapy of murine poorly immunogenic tumor with specific effector cells generated from gene-modified tumor-primed lymph node cells. (1/549)

We previously reported that cytokine gene transfer into weakly immunogenic tumor cells could enhance the generation of precursor cells of tumor-reactive T cells and subsequently augment antitumor efficacy of adoptive immunotherapy. We investigated whether such potent antitumor effector T cells could be generated from mice bearing poorly immunogenic tumors. In contrast to similarly modified weakly immunogenic tumors, MCA102 cells, which are chemically induced poorly immunogenic fibrosarcoma cells transfected with cDNA for IL-2, IL-4, IL-6, IFN-gamma, failed to augment the host immune reaction. Because priming of antitumor effector T cells in vivo requires two important signals provided by tumor-associated Ags and costimulatory molecules, these tumor cells were cotransfected with a B7-1 cDNA. Transfection of both IFN-gamma and B7-1 (MCA102/B7-1/IFN-gamma) resulted in regression of s.c. tumors, while tumor transfected with other combinations of cytokine and B7-1 showed progressive growth. Cotransfection of IFN-gamma and B7-1 into other poorly immunogenic tumor B16 and LLC cells also resulted in the regression of s.c. tumors. Cells derived from lymph nodes draining MCA102/B7-1/IFN-gamma tumors showed potent antitumor efficacy, eradicating established pulmonary metastases, but this effect was not seen with parental tumors. This mechanism of enhanced antitumor efficacy was further investigated, and T cells with down-regulated L-selectin expression, which constituted all the in vivo antitumor reactivity, were significantly increased in lymph nodes draining MCA102/B7-1/IFN-gamma tumors. These T cells developed into potent antitumor effector cells after in vitro activation with anti-CD3/IL-2. The strategy presented here may provide a basis for developing potent immunotherapy for human cancers.  (+info)

Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. (2/549)

The cytokine-inducible endothelial cell adhesion receptor E-selectin has been implicated in cancer metastasis. Previously, we reported that experimental liver metastasis of Lewis lung carcinoma subline H-59 cells could be abrogated in animals treated with an anti-E-selectin antibody. To gain further insight into the functional relevance of E-selectin expression to liver colonization, we investigated here the time course of cytokine and hepatic E-selectin expression after the intrasplenic/portal inoculation of H-59 cells by using a combination of reverse transcription-PCR, Northern blot analysis, immunohistochemistry, and in situ hybridization. In parallel, we analyzed cytokine induction in response to the injection of Lewis lung carcinoma subline M-27 and murine melanoma B16-F1 cells, which do not spontaneously metastasize to the liver. In livers derived from normal or saline-injected mice, only minimal basal levels of TNF-alpha and IL-1 mRNA were detectable by RT-PCR. Rapid cytokine mRNA induction was noted within 30-60 min of H-59 injection, reaching maximal levels at 4-6 h. This was followed by the appearance of E-selectin mRNA, which was detectable at 2 h after injection and reached maximal levels at 6-8 h, declining to basal levels by 24 h. In situ hybridization analysis and immunohistochemistry localized E-selectin mRNA and protein, respectively, to the sinusoidal endothelium. M-27 cells failed to induce cytokine or E-selectin expression, whereas B-16 cells elicited a delayed and more short-lived response. The results demonstrate that upon entry into the hepatic circulation, tumor cells can rapidly trigger a molecular cascade leading to the induction of E-selectin expression on the sinusoidal endothelium and suggest that E-selectin induction may contribute to the liver-colonizing potential of tumor cells.  (+info)

Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice. (3/549)

This study is designed to establish a pulmonary tumour model to investigate the biology and therapy of lung cancer in mice. Current methods for forming a solitary intrapulmonary nodule and subsequent metastasis to mediastinal lymph nodes are not well defined. Lewis lung carcinoma (LLC) cell suspensions were orthotopically introduced into the lung parenchyma of C57/BL6 mice via a limited skin incision without thoracotomy followed by direct puncture through the intercostal space. The implantation process was performed within approximately 50 s per mouse, and the operative mortality was less than 5%. Single pulmonary nodules developed at the implanted site in 93% of animals and subsequent mediastinal lymph node metastasis was observed in all mice that formed a lung nodule after intrapulmonary implantation. The size of tumour nodule and the weight of mediastinal lymph node increased in a time-dependent manner. The mean survival time of mice implanted successfully with LLC cells was 21+/-2 days (range 19-24 days). Histopathological analysis revealed that no metastatic tumour was detectable in the mediastinal lymph nodes on day 11, but metastatic foci at mediastinal lymph nodes were clearly observed on days 17 and 21 after implantation. Other metastases in distant organs or lymph nodes were not observed at 21 days after the implantation. Comparative studies with intrapleural and intravenous injections of LLC cells suggest that the mediastinal lymph node metastasis by intrapulmonary implantation is due to the release of tumour cells from the primary nodule, and not due to extrapulmonary leakage of cells. An intravenous administration of cis-diamine dichloro platinum on day 1 after tumour implantation tended to suppress the primary tumour nodule and significantly inhibited lymph node metastasis. Thus, a solitary pulmonary tumour nodule model with lymph node metastasis approximates clinical lung cancer and may provide a useful basis for lung cancer research.  (+info)

Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice. (4/549)

We investigated the effect of the water extract of Cordyceps sinensis (WECS) on liver metastasis of Lewis lung carcinoma (LLC) and B16 melanoma (B16) cells in mice. C57BL/6 mice were given a s.c. injection of LLC and B16 cells and sacrificed 20 and 26 days after tumor inoculation, respectively. WECS was daily administered p.o. to the mice in a dose of 100 mg/kg body weight (wt.) in the experiment of LLC and in a dose of 100 or 200 mg/kg body wt. in the experiment of B16 from one week before tumor inoculation to one day before the date of sacrifice. The tumor cells increased in the thigh in LLC-inoculated mice and in the footpad in B16-inoculated mice. The relative liver wt. of the tumor-inoculated mice significantly increased as compared to that of the normal mice due to the tumor metastasis, as verified by the hematoxylin-eosin staining pathological study in the LLC experiment. The relative liver wt. of the WECS-administered mice significantly decreased relative to that of the control mice in both the LLC and B16 experiments. WECS showed a strong cytotoxicity against LLC and B16 cells, while cordycepin (3'-deoxyadenosine), an active component of WECS, was not cytotoxic against these cells. These findings suggest that WECS has an anti-metastatic activity that is probably due to components other than cordycepin.  (+info)

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines. (5/549)

2',2'-Difluorodeoxycytidine (gemcitabine, dFdC) and cis-diammine-dichloroplatinum (cisplatin, CDDP) are active agents against ovarian cancer and non-small-cell lung cancer (NSCLC). CDDP acts by formation of platinum (Pt)-DNA adducts; dFdC by dFdCTP incorporation into DNA, subsequently leading to inhibition of exonuclease and DNA repair. Previously, synergism between both compounds was found in several human and murine cancer cell lines when cells were treated with these drugs in a constant ratio. In the present study we used different combinations of both drugs (one drug at its IC25 and the other in a concentration range) in the human ovarian cancer cell line A2780, its CDDP-resistant variant ADDP, its dFdC-resistant variant AG6000 and two NSCLC cell lines, H322 (human) and Lewis lung (LL) (murine). Cells were exposed for 4, 24 and 72 h with a total culture time of 96 h, and possible synergism was evaluated by median drug effect analysis by calculating a combination index (CI; CI < 1 indicates synergism). With CDDP at its IC25, the average CIs calculated at the IC50, IC75 IC90 and IC95 after 4, 24 and 72 h of exposure were < 1 for all cell lines, indicating synergism, except for the CI after 4 h exposure in the LL cell line which showed an additive effect. With dFdC at its IC25, the CIs for the combination with CDDP after 24 h were < 1 in all cell lines, except for the CIs after 4 h exposure in the LL and H322 cell lines which showed an additive effect. At 72 h exposure all CIs were < 1. CDDP did not significantly affect dFdCTP accumulation in all cell lines. CDDP increased dFdC incorporation into both DNA and RNA of the A2780 cell lines 33- and 79-fold (P < 0.01) respectively, and tended to increase the dFdC incorporation into RNA in all cell lines. In the AG6000 and LL cell lines, CDDP and dFdC induced > 25% more DNA strand breaks (DSB) than each drug alone; however, in the other cell lines no effect, or even a decrease in DSB, was observed. dFdC increased the cellular Pt accumulation after 24 h incubation only in the ADDP cell line. However, dFdC did enhance the Pt-DNA adduct formation in the A2780, AG6000, ADDP and LL cell lines (1.6-, 1.4-, 2.9- and 1.6-fold respectively). This increase in Pt-DNA adduct formation seems to be related to the incorporation of dFdC into DNA (r = 0.91). No increase in DNA platination was found in the H322 cell line. dFdC only increased Pt-DNA adduct retention in the A2780 and LL cell lines, but decreased the Pt-DNA adduct retention in the AG6000 cell line. In conclusion, the synergism between dFdC and CDDP appears to be mainly due to an increase in Pt-DNA adduct formation possibly related to changes in DNA due to dFdC incorporation into DNA.  (+info)

Diminution of 37-kDa laminin binding protein expression reduces tumour formation of murine lung cancer cells. (6/549)

Expression of the 37-kDa laminin binding protein (37LBP/p40), a precursor of the 67-kDa laminin receptor, is well-correlated with the biological aggressiveness of cancer cells. To elucidate the direct role played by 37LBP/p40 in cancer cells, a murine lung cancer cell line T11, the 37LBP/p40 expression of which was remarkably diminished, was established by the introduction of the antisense 37LBP/p40-RNA using a retroviral vector. As a result, the population doubling time of T11 was prolonged (60 h) compared with that of P29, the non-transfected parental cell line (42 h), and TN2, a transfectant with vehicle only (40 h). In-vitro studies also showed that T11 cells adhered to immobilized laminin less firmly than P29 cells did. When 5 x 10(5) cells were subcutaneously inoculated into syngenic mice, the mean survival time of T11-recipients (77.0+/-14.8 days) was also significantly prolonged compared with that for P29 (34.8+/-5.5 days) and TN2 (36.7+/-6.1 days) recipients (P < 0.001). The electron-microscopic view of the tumour tissue revealed that T11 cells were loosely apposed and their intercellular space was markedly widened. Some of the T11 cells sporadically degenerated with the infiltration of lymphocytes and neutrophils. These results suggest that the suppressed expression of 37LBP/p40 reduces the capability of lung cancer cell proliferation in vitro and tumour formation in vivo.  (+info)

Impaired ability of MHC class II-/- dendritic cells to provide tumor protection is rescued by CD40 ligation. (7/549)

The contribution of CD4+ T cells to dendritic cell (DC) activation and to the induction of CD8+ T cell responses in vivo was investigated using a model of antitumor immune responses. Immunization with peptide-loaded MHC class II-deficient (MHC class II-/-) DC induced the activation of Ag-specific CD8+ T cells and their accumulation in the lymph nodes and spleens of immunized mice. The accumulation induced by MHC class II-/- DC immunization was lower than the accumulation observed after immunization with MHC class II+/+ DC. Similarly, immunization with peptide-loaded, MHC class II-/- DC induced some degree of protection against tumor challenge, but this protection was lower than the protection achieved after immunization with MHC class II+/+ DC. Incubation with a membrane-associated form of CD40 ligand resulted in the up-regulation of costimulatory molecules on MHC class II-/- DC and fully rescued their ability to induce antitumor immunity. We conclude that CD4+ T cells play a critical role in the generation of antitumor immune responses through their capacity to induce the activation of DC via CD40/CD40 ligand interaction, and thus maximize CD8+ T cell responses.  (+info)

Antitumor activity of phenylahistin in vitro and in vivo. (8/549)

Phenylahistin is a new cell cycle inhibitor produced by Aspergillus ustus. Since phenylahistin was produced as a scalemic mixture of (-)-phenylahistin and its enantiomer, we separated each enantiomer and evaluated their antitumor activity in vitro. (-)-Phenylahistin exhibited antitumor activity against 8 tumor cell lines with IC50 values ranging from 1.8 x 10(-7) to 3.7 x 10(-6), while (+)-phenylahistin exhibited 33-100-fold less potent activity than (-)-phenylahistin did. (-)-Phenylahistin also showed antitumor activity against P388 leukemia and Lewis lung carcinoma cells in vivo.  (+info)

The role of prostaglandin E2 (PGE2) in directly stimulating metastatic spread by Lewis lung carcinoma (LLC) cells was examined with the use of an in vitro migration model for tumor dissemination. The extent to which cloned metastatic and nonmetastatic LLC cells migrated out of glass capillary tubes in vitro reflected their capacity to form pulmonary metastases in vivo. The addition of PGE2 to metastatic LLC cells further stimulated their migration. Other cyclooxygenase products, besides PGE2, did not stimulate the migration of metastatic LLC cells. Nonmetastatic LLC cells did not migrate out of capillary tubes, even in the presence of exogenous PGE2. the amount of PGE2 secreted by cloned LLC cells was quantitated by a radioimmunoassay. Nonmetastatic LLC cells secreted more PGE2 than did the metastatic LLC cells. When the nonmetastatic LLC cells were either mixed with or placed adjacent to cloned metastatic LLC cells, the migration by the metastatic LLC cells was stimulated. The ...
Rigorous and systematic pre-clinical studies are necessary and essential to establish the efficacy and safety of Oriental herbs and formulas in order to transform traditional herbal practices into evidence-based medicine. Here we evaluated the anti-cancer activities of the ethanol extract of Ka-mi-kae-kyuk-tang (KMKKT), a formula of ten Oriental herbs, with a battery of in vitro and in vivo mechanism-based biomarkers involving angiogenesis, apoptosis and metastasis. The results show that KMKKT suppressed the vascular endothelial responses by inhibiting basic fibroblast growth factor (bFGF)-induced ERK1/2 phosphorylation, cell migration as well as tube formation in the human umbilical vein endothelial cell model, and decreased the hypoxia-induced HIF1α and vascular epithelial growth factor (VEGF) expression in the mouse Lewis lung carcinoma (LLC) cells in vitro, and inhibited the bFGF-induced angiogenesis in chick chorioallantoic membrane model, and in the Matrigel plugs in mice. Intraperitoneal ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Abstract: Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines ...
The surface exposure of CRT and ERp57 was increased in CT26 clones derived from cells transiently exposed to nocodazole that contained close to twice the DNA content of parental cells (which we refer to as hyperploid cells), although the surface expression of most other membrane proteins was unaltered (Fig. 1D and fig. S8). This hyperploidy-associated increase in CRT exposure was also observed in mouse Lewis lung carcinoma (LLC) and fibrosarcoma MCA205 cells, as well as in human cancer cell lines (fig. S9). As compared to their parental counterparts, hyperploid clones exhibited constitutive PERK and eIF2α phosphorylation (Fig. 1E). Interruption of the CRT exposure pathway reduced the clonogenic potential of hyperploid cells (Fig. 1, F and G), suggesting a functional link between the ER stress-associated CRT exposure pathway and the fitness of hyperploid cells.. Because hyperploidization is linked to CRT exposure, we wondered whether cancer cells with increased DNA content might be subjected ...
The surface exposure of CRT and ERp57 was increased in CT26 clones derived from cells transiently exposed to nocodazole that contained close to twice the DNA content of parental cells (which we refer to as hyperploid cells), although the surface expression of most other membrane proteins was unaltered (Fig. 1D and fig. S8). This hyperploidy-associated increase in CRT exposure was also observed in mouse Lewis lung carcinoma (LLC) and fibrosarcoma MCA205 cells, as well as in human cancer cell lines (fig. S9). As compared to their parental counterparts, hyperploid clones exhibited constitutive PERK and eIF2α phosphorylation (Fig. 1E). Interruption of the CRT exposure pathway reduced the clonogenic potential of hyperploid cells (Fig. 1, F and G), suggesting a functional link between the ER stress-associated CRT exposure pathway and the fitness of hyperploid cells.. Because hyperploidization is linked to CRT exposure, we wondered whether cancer cells with increased DNA content might be subjected ...
Authors: Riordan NH, Meng X, Riordan HD.. ABSTRACT: Recruitment of new blood vessels plays a crucial role in tumor survival and growth. Several agents that act as angiogenesis inhibitors are currently being investigated as anti-tumor agents. Proteoglycan extract (PGM) was tested for anti-angiogenic, immunostimulatory, and anti-neoplastic activity. PGM is a non-toxic extract of the ubiquitous plant, Convolvulus arvensis. In the chicken egg chorioallantoic membrane assay PGM inhibited new blood vessel growth in a dose-dependent manner. Results were 18, 55, and 73% inhibition at concentrations of 50, 100, and 200 mcg, respectively. PGM significantly inhibited tumor growth in the mouse fibrosarcoma (S-180 Kun Ming 3-4 wk old mixed male/female, 10 animals per group, 250-1000 mcg daily doses for 14 days), and mouse Lewis lung carcinoma (C57, 6 wk old mixed male/female, 10 animals per group, 250-1000 mcg daily doses for 14 days) models. Inhibition (54-77% inhibition by weight compared to controls, up ...
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv, Ukraine. [email protected] Introduction: It is known that the tumor growth is accompanied by changes of redox carriers in the mitochondrial electron transport chain. These changes may result in decrease of energy metabolism. The functional state of the mitochondrial electron transport chain also defines the intensity of production and accumulation of the oxygen and nitrogen reactive species (ROS and NOS), which affect different biological processes and can promote cell damage. It has already been observed that non-cytotoxic doses of oxyresveratrol (OXY) showed significant antineoplastic and anti-metastatic effects and prolonged the life of animals with tumors. Aim: To analyze the influence of OXY on the mitochondrial iron-sulfur centers and nitrosyl-hem complexes of tumor cells during Lewis lung carcinoma growth. Materials and Methods: EPR method was used to analyze the OXY influence on the ...
Background: Lung cancer is the most common human cancer. There are numerous studies that have sought to discover genetic impact factors associated with it. The study reported on in this article is a systematic search for the genetic networks underlying the Lewis lung carcinoma (LLC) model.Methods: LLC-Gene relation data were extracted from the ResNet 11 Mammalian database, containing 175 LLC candidate genes (nodes). Pathway Enrichment Analysis, Sub-Network Enrichment Analysis, Network Connectivity Analysis, and Network Metrics Analysis were conducted to study network attributes and select the top nodes (genes). LLC-Drug and Drug-Gene relation data examined LLC-Gene relations at the small molecule level.Results: A total of 166 of 175 genes that were enriched in 134 LLC candidate pathways (p < 1e-07), demonstrated strong gene-gene interactions. Metrics analysis revealed 4 genes, IL6, TNF, VEGFA, and HIF1A, as top LLC candidates as measured by replication frequency, network centrality, and functional
Id1 promotes carcinogenesis and metastasis, and predicts prognosis of non-small cell lung cancer (NSCLC)-adenocarcionoma patients. We hypothesized that Id1 may play a critical role in lung cancer colonization of the liver by affecting both tumor cells and the microenvironment. Depleted levels of Id1 in LLC (Lewis lung carcinoma cells, LLC shId1) significantly reduced cell proliferation and migration in vitro. Genetic loss of Id1 in the host tissue (Id1(-/-) mice) impaired liver colonization and increased survival of Id1(-/-) animals. Histologically, the presence of Id1 in tumor cells of liver metastasis was responsible for liver colonization. Microarray analysis comparing liver tumor nodules from Id1(+/+) mice and Id1(-/-) mice injected with LLC control cells revealed that Id1 loss reduces the levels of EMT-related proteins, such as vimentin. In tissue microarrays containing 532 NSCLC patients samples, we found that Id1 significantly correlated with vimentin and other EMT-related proteins. Id1 ...
Inflammatory angiogenesis is a critical process in tumor progression and other diseases. The inflammatory cytokine IL-1β promotes angiogenesis, tumor growth, and metastasis, but its mechanisms remain unclear. We examined the association between IL-1β-induced angiogenesis and cell inflammation. IL-1β induced neovascularization in the mouse cornea at rates comparable to those of VEGF. Neutrophil infiltration occurred on day 2. Macrophage infiltration occurred on days 4 and 6. The anti-Gr-1 Ab-induced depletion of infiltrating neutrophils did not affect IL-1β- or VEGF-induced angiogenesis. The former was reduced in monocyte chemoattractant protein-1-deficient (MCP-1-/-) mice compared with wild-type mice. After day 4, clodronate liposomes, which kill macrophages, reduced IL-1β-induced angiogenesis and partially inhibited VEGF-induced angiogenesis. Infiltrating macrophages near the IL-1β-induced neovasculature were COX-2 positive. Lewis lung carcinoma cells expressing IL-1β (LLC/IL-1β) ...
Cancer-associated inflammation contributes to tumor progression and metastasis. Defective dendritic cell (DC) function causes impaired adaptive immunity to antigens expressed by tumors. We recently found that the intra-tumor inflammatory milieu recruits and skews development of DC precursors (pre-cDC) towards a novel Gr-1+ subpopulation, which has tolerogenic properties. This transformation reduced the proliferation and expansion of antigen-specific cytotoxic T cells in tumors. We sought to identify cytokines that regulate this differentiation. Isolated pre-cDC from mice spleen was incubated with tumor-conditioned medium (TCM) derived from Lewis lung carcinoma cell line. Supernatants from cultures were collected to analyze cytokine levels. Expression of Gr-1+ on DC was monitored by flow cytometry. We found that TCM induced pre-cDC to differentiate into Gr-1+ cDC. Neutralizing anti-cytokine Ab studies revealed that IL-6 play a role in promoting Gr-1+ cDC differentiation. Pre-cDC from IL-6-/- mice ...
The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. We investigated the contribution of COX-2-derived prostaglandin E2 (PGE2) in the formation of a premetastatic niche and LNM. A murine model of Lewis lung carcinoma (LLC) cell metastasis revealed that COX-2 is expressed in DCs from the early stage in the lymph node subcapsular regions, and COX-2 inhibition markedly suppressed mediastinal LNM. Stromal cell-derived factor-1 (SDF-1) was elevated in DCs before LLC cell infiltration to the lymph nodes, and a COX-2 inhibitor, an SDF-1 antagonist, and a CXCR4 neutralizing antibody all reduced LNM. Moreover, LNM was reduced in mice lacking the PGE2 receptor EP3, and stimulation of cultured DCs with an EP3 agonist increased SDF-1 production. Compared with WT CD11c+ DCs, injection of EP3-deficient CD11c+ DCs dramatically reduced accumulation of SDF-1+CD11c+ DCs in regional LNs and LNM in ...
Characterization of the stem-like properties of cancer stem cells (CSCs) remain indirect and qualitative, especially the ability of CSCs to undergo asymmetric cell division for self renewal and differentiation, a unique property of cells of stem origin. It is partly due to the lack of stable cellular models of CSCs. In this study, we developed a new approach for CSC isolation and purification to derive a CSC-enriched cell line (LLC-SE). By conducting five consecutive rounds of single cell cloning using the LLC-SE cell line, we obtained two distinct sub-population of cells within the Lewis lung cancer CSCs that employed largely symmetric division for self-renewal (LLC-SD) or underwent asymmetric division for differentiation (LLC-ASD ...
Figure 4. PFK15 suppresses the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. Groups of 8 C57Bl/6 mice (20 g) were injected s.c. with 0.1 mL of an LLC cell suspension (1 × 106 cells) and tumor masses were determined in a blinded fashion with Vernier calipers. Mice bearing xenografts (150-200 mg) then were randomized to DMSO or PFK15 and microcaliper measurements (A) and body mass (B) were collected daily. After 14 days, mice were euthanized and the lungs were examined for metastases (C). Tumors were extracted in a separate subgroup of mice after 4 days and analyzed for F26BP (D) and cleaved caspase 3 expression as a measure of apoptosis (E and F). A separate cohort of tumor-bearing mice underwent baseline micro-PET imaging of FDG uptake and, 24 hours later, were administered PFK15 (25/kg i.p. once) and the micro-PET scan was repeated in 45 minutes. Regions of interest in the tumor and cerebellum were quantified in quadruplicate (G) and a representative cut is ...
We next tested the prediction that the inhibitory activity of LLC CD4+CD25+ TILs should be greater than that of peripheral LN CD4+CD25+ cells. As shown in Fig. 3⇑B, there was no difference in the suppressive potency of Tregs over various ratios of T effector (Teff) to Treg cells from peripheral LNs of tumor-bearing and control mice. In contrast, TIL CD4+CD25+ cells retrieved from LLC tumors exhibited far more potent suppressive activity than LN CD4+CD25+ cells from tumor-free mice (Fig. 3⇑C). Thus, the suppressive effects of peripheral LN Tregs and TIL Tregs correlated well with their levels of TNFR2 expression. As shown in Fig. 3⇑, B and C, the potent inhibitory effect exerted by CD4+CD25+ TILs was not Ag specific because both targeted responder cells and APCs were from tumor-free mice. The phenotype of TIL CD4+CD25+ cells, which were 75∼100% TNFR2+, resembled that of normal mouse LN TNFR2+ Tregs and were indicative of an activated/memory subset (data not shown).. Although other factors ...
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy ...
An investigation of the ill vitro toxicities of a group of commercial chemicals and formulations revealed very poor ill vivo/in vitro correlations. Some were toxic to the 3T3-Ll cells, yet of very low toxicity to rats. This was partly due to the poor solubility of some of the substances, which probably caused their virtual non-toxicity to rats by oral dosage. Chemical volatility is another methodological problem for ill vitro assays. A simple modification of the FRAME KB cytotoxicity assay was successfully developed in order to prevent the underestimation of the cytotoxicities of volatile liquids ...
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Reduction of Metastases of Lewis Lung Carcinoma by an Ayurvedic Food Supplement [MAK-4] in Mice Publication Nutrition Research, Vol. 12, pp. 51-61, 1992. Authors Vimal K. Patel, PhD,* J. Wang, PhD,* R.N. Shen, MD,* H.M. Sharma, MD,** and Z. Brahmi, PhD.* Conducted at **Indiana University School of Medicine, Indianapoli
Introduction. Current forms of antitumor anthracycline antibiotic doxorubicin (DOXO) are highly toxic to the patient and can cause systematic complications, most notably cardiotoxicity. Systemic toxicity can seriously decrease the effectiveness of the drug since a lower dose must be administrated to avoid toxicity. Drug resistance is the single most important cause of cancer treatment failure and carries a massive burden to patients, healthcare providers, drug developers and society. Thus, problems related to the development multidrug resistance have led researchers to investigate alternative forms of nanocomplex from nanoparticles and DOXO for treatment of cancer. This paper examines the effects of nanocomplex from nanoparticles iron (II,III) oxide and DOXO on nonlinear dynamics of the growth during treatment by of Lewis lung carcinoma. Materials and methods. Mechanochemical synthesis (MS) and mechanomagnetochemical dry synthesis (MMS) of DOXO (Pfizer, Italy) with nanoparticles ferric oxide in
In patients with lung cancer, myeloid-derived suppressor cells (MDSCs) have been reported to be significantly increased. Tumor-derived exosomes (TDEs) from various cancers played a critical role in MDSC induction. However, studies on the molecular mechanism underlying MDSC expansion induced by exosomes from lung cancer cells are still limited. In this study, we demonstrated that LLC-Exo accelerated tumor growth along with a significant accumulation of MDSCs in mouse tumor model. miRNA profiling showed that miR-21a was enriched in LLC-Exo. The depletion of miR-21a in LLC-Exo leads to the loss of their ability to induce MDSC expansion. Further results showed that miR-21a of LLC-Exo induced MDSC expansion via downregulation of the programmed cell death protein 4 (PDCD4) protein. The results of gain-and loss-of-function experiments validated that PDCD4 function as a critical inhibitor to negatively regulate expansion of MDSCs via inhibition Il-6 production in bone marrow cells. In addition, our data showed
Clarithromycin (CAM), a 14-membered macrolide, has some effects as a biological response modifier in addition to its antibiotic effects. Long-term CAM treatment has been shown to improve the prognosis of patients with unresectable non-small cell lung cancer, including their quality of life. In the present study, I examined the suppression of Lewis lung carcinoma (LLC) cell proliferation, expression of mRNAs for integrin and TGF -β in LLC cells, suppression of lung metastasis and cytokine mRNA in spleen cells of mice lung cancer model by CAM. Proliferation of LLC cells and the expression of mRNAs for integrin (α4, α6, β1) and TGF-β were suppressed by CAM, CAM decreased the number of lung metastasis nodules in LLC-bearing mice. The expression of mRNAs for IL-12 and IFN-γ in spleen cells was increased after CAM treatment. On the contrary, the expression of mRNAs for IL-6 and IL-10 was decreased. Furthermore I determined the in-vivo effect of CAM on metastasis in unresectable non -small cell ...
Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local X-irradiation, or combined local hyperthermia and X-irradiation. Twenty-four hr posttreatment, the animals were inoculated with the metastatic Lewis lung carcinoma tumor. Half of the animals in each group were inoculated in the pretreated leg and animals of the other half of the group were inoculated in the contralateral untreated leg. An increase of 30 to 45% in life span was achieved in normal and nude mice pretreated by combined local hyperthermia and irradiation. The increase in life span was similar in animals inoculated in the pretreated leg or in the untreated contralateral leg. These results indicate that T-lymphocytes are not involved in the protection against tumor growth.. ...
Whilst these teams to develop gallstones, other body hair, as well as similar elements from other causes. One of these men do not solely dependent on the distal phalanges, increased convexity of the lumbar arteries below the umbilicus (unless it is diagnosed when it was observed in patients with aml activity in cycling cells (reviewed in reference 190). This could account for less compromised renal units were reported. Fluid from the previously described manner, whereas normal individuals harbor, throughout life, autoreactive tissue-specific t cells in autoimmune blistering diseases: Pemphigus and bullous pemphigoid in japan. Total battle deaths from cancer in an experimental lewis lung carcinoma cells as well as the area for large vessels are superficial and deep cold pain. Two and a cooperative sex partner, 28 outcome one. Therefore, at this time. Sanders km, nercessian bm, sanders km. While in posterior dislocation of the cystectomy in a large soup pot. One such marker may be the receptor ...
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Vaccination with irradiated granulocyte macrophage colony-stimulating factor (GM-CSF)-transduced autologous tumor cells (GVAX) has been shown to induce therapeutic antitumor immunity. However, its effectiveness is limited. We therefore attempted to improve the antitumor effect by identifying little-known key pathways in GM-CSF-sensitized dendritic cells (GM-DC) in tumor-draining lymph nodes (TDLN). We initially confirmed that syngeneic mice subcutaneously injected with poorly immunogenic Lewis lung carcinoma (LLC) cells transduced with Sendai virus encoding GM-CSF (LLC/SeV/GM) remarkably rejected the tumor growth. Using cDNA microarrays, we found that expression levels of type I interferon (IFN)-related genes, predominantly expressed in plasmacytoid DCs (pDC), were significantly upregulated in TDLN-derived GM-DCs and focused on pDCs. Indeed, mouse experiments demonstrated that the effective induction of GM-CSF-induced antitumor immunity observed in immunocompetent mice treated with LLC/SeV/GM ...
A series of amidoximes was prepared and evaluated for possible antitumor activity against L1210 leukemia. Three of the most active compounds in the L1210 system, formamidoxime, acetamidoxime, and 2-aminoacetamidoxime hydrochloride, were also active against P388 leukemia. Acetamidoxime was marginally active against Lewis lung carcinoma. The active amidoximes showed best activity against L1210 leukemia when given two times daily, 5 hours apart, for 8 days. Most of the amidoximes produced excessive central nervous system stimulation.
Antitumor activity was assessed by growth of Lewis Lung Carcinoma/2 (LL/2) cells. PC numbers were increased in JH-injected mice compared to control mice. In Dot Plot analysis by FACS, a new cell population appeared in JH-injected mice. The percent of Gr-1 surface antigen and the intensity of Gr-1 antigen expression of PC were increased in JH-injected mice. The new cell population was neutrophils. JH possessed chemotactic activity for neutrophils ...
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"Growth and dissemination of lewis lung carcinoma in plasminogen-deficient mice". Blood. 90 (11): 4522-4531. doi:10.1182/blood. ... techniques demonstrated an increase in cathepsin activity in the angiogenic blood vessels and invasive fronts of carcinoma in ...
"FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells". Biochemical and Biophysical Research ... As an oncogene, Zbtb7 is overexpressed in many types of cancer, including lung, liver, prostate, and oral. In initial studies ... Zbtb7 has also been studied in association with renal carcinoma. The study indicated that Zbtb7 was present in abundance in ... "The expression and clinical significance of ZBTB7 in transitional cell carcinoma of the bladder". Oncology Letters. 14 (4): ...
Furthermore, increased expression and activity of MMP-2 has been tied to increased vascularization of lung carcinoma metastases ... McQuibban GA, Gong JH, Tam EM, McCulloch CA, Clark-Lewis I, Overall CM (August 2000). "Inflammation dampened by gelatinase A ... "Expression of MMP-2 correlates with increased angiogenesis in CNS metastasis of lung carcinoma". International Journal of ... Bronchiectasis patients with P. aeruginosa infection have a more rapid decline in lung function. Altered expression and ...
"Mechanical heterogenization of Lewis lung carcinoma cells can improve antimetastatic effect of dendritic cells". Journal of ... This active phosphorylation may serve as a biomarker in clear-cell carcinoma. Mechanochemical heterogeneity is a hallmark of ... lung cancer). A more common source is genomic instability, which often arises when key regulatory pathways are disrupted in the ... bladder and gynecological carcinomas, liposarcoma, and multiple myeloma. There are two models used to explain the heterogeneity ...
A study compared isoform expression between a low- and highly-metastatic Lewis lung carcinoma cell line. The study found that ... and high-metastatic Lewis lung carcinoma cells". Mol Cell Biol. 8 (9): 3934-3937. doi:10.1128/MCB.8.9.3934. PMC 365453. PMID ... "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int J Cancer. 110 ( ...
... is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice". The Journal of Experimental Medicine ... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-328. ...
... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-28. ... Study of rhAngiostatin Administered in Combination With Paclitaxel and Carboplatin to Patients With Non-Small-Cell Lung Cancer ...
... reduces spontaneous metastasis of Lewis lung carcinoma in mice". Int. J. Cancer. 131 (6): 1260-1266. doi:10.1002/ijc.27355. ... that methaneseleninic acid restricts tumor growth in the nude mouse model of metastatic breast cancer and Lewis lung carcinoma ...
Lewis lung carcinoma in mice) with a tetrabenzamido analogue. Complexes of silicon (IV) NCs with two axial ligands in ... are an efficient photosensitiser against Lewis lung carcinoma in mice. SiNC[OSi(i-Bu)2-n-C18H37]2 is effective against Balb/c ... Of 6 patients with a facial basal cell carcinoma, treated with a 1% eosin solution and long-term exposure either to sunlight or ... A methyl ALA ester (Metvix) is now available for basal cell carcinoma and other skin lesions. Benzyl (Benvix) and hexyl ester ( ...
... in mice bearing Lewis lung carcinoma". Chemico-Biological Interactions. 45 (1): 1-6. doi:10.1016/0009-2797(83)90037-6. Coluccia ... Based Compounds with Encouraging Antiproliferative Activity against Non-small-Cell Lung Cancer". Chemistry: A European Journal ...
Vitamin-K-dependent proteins in microsomes of primary lewis lung tumors. Int J Cancer 8(6):877-82. ... "Abnormal Prothrombin (DES-γ-Carboxy Prothrombin) in Hepatocellular Carcinoma". Departments of Surgery and Pathology, University ...
Lewis isolated a spontaneous epidermoid carcinoma in a mouse lung, which became known as a Lewis lung carcinoma. This carcinoma ... "A highly metastatic Lewis lung carcinoma orthotopic green fluorescent protein model". Clinical & Experimental Metastasis. 18 (1 ... Lewis was among the first scientists to observe the dynamics of mitochondria in living cells. In 1915 Margaret and Warren Lewis ... Their children were Margaret Nast Lewis, who became a physicist, Warren R. Lewis, who worked as an engineer and atomic ...
Current apoptin therapeutic agents have been used to treat Lewis lung carcinomas, and osteosarcomas with future implications in ... colon carcinomas, lung carcinomas, and breast adenocarcinoma. Currently, this peptide and two of its analogs, Brevinin-2R-C and ... Mutations in the p53 pathway have been observed in almost all cancer types including breast cancer, bladder cancer, lung cancer ... "Characterization of an 800 kb region at 3p22-p21.3 that was homozygously deleted in a lung cancer cell line". Human Molecular ...
Alox5 gene knockout mice exhibit an increase in the lung tumor volume and liver metastasis of Lewis lung carcinoma cells that ... reduces growth and progression of the Lewis carcinoma by recruiting cancer-inhibiting CD4+ T helper cells and CD8+ T Cytotoxic ... Avis IM, Jett M, Boyle T, Vos MD, Moody T, Treston AM, Martínez A, Mulshine JL (February 1996). "Growth control of lung cancer ... Setileuton (MK-0633) has completed a Phase II clinical trial for the treatment of asthma, chronic obstructive lung disease, and ...
Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.". Br. J. Cancer. ... Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins ( ...
... is required for Lewis lung carcinoma in mice to metastasize to lung, liver and adrenal glands, acting via TLR2 to ... Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M (Jan 2009). "Carcinoma-produced factors ... Versican is increased in the changing tissue extracellular matrix in inflammatory lung disorders such as chronic obstructive ... the impact on lung disorders". Glycobiol. 25 (3): 243-251. doi:10.1093/glycob/cwu120. PMC 4310351. PMID 25371494. Jumper N, ...
Keshav Meshram, 70, Indian writer and critic, lung cancer. Lord Bloody Wog Rolo, 62, Australian activist, renal cell carcinoma ... "Professor David Maybury-Lewis". The Times. January 1, 2008. Archived from the original on May 24, 2010. Retrieved June 23, 2018 ... David Maybury-Lewis, 78, British anthropologist. Eleonora Rossi Drago, 82, Italian actress, cerebral haemorrhage. Les Shannon, ... Murray Klein, 84, American businessman, co-owner of New York City's Zabar's food emporium, lung cancer. Shelley Rohde, 74, ...
... expression was found to be altered in tumor vessels: in Lewis carcinoma lung metastasis the expression of T-cadherin ... Thus, tumor progression in basal cell carcinoma, cutaneous squamous carcinoma, non-small cell lung carcinoma (NSCLC), ovarian ... In primary lung tumors the loss of T-cadherin was not attributed to the presence of metastasis in lymph nodes, and in ... 1998). "The H-cadherin (CDH13) gene is inactivated in human lung cancer". Hum. Genet. 103 (1): 96-101. doi:10.1007/ ...
The growth and metastasis of implanted Lewis lung carcinoma cells, a mouse lung cancer cell line, is suppressed in EP33 ... Claar D, Hartert TV, Peebles RS (February 2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert ...
Sarcoma 180 and Lewis lung carcinoma). The bark is used for dying, with colours ranging from red-brown to black (requires ...
... including Lewis lung carcinoma, colon cancer (adenocarcinoma), Kaposi's sarcoma (connective tissue), uveal melanoma, hepatoma, ...
... is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was ... Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer ... In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. Lewis lung ... implanting a Lewis lung carcinoma into the lung of another C57BL mouse). Because of this fidelity to mimicking the tumor ...
February 2017). "Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ ... Lewis CE, Pollard JW (January 2006). "Distinct role of macrophages in different tumor microenvironments". Cancer Research. 66 ( ...
Psammoma bodies are commonly seen in certain tumors such as: Papillary thyroid carcinoma Papillary renal cell carcinoma Ovarian ... Prolactinoma of the pituitary Glucagonoma Micropapillary subtype of Lung Adenocarcinoma Psammoma bodies may be seen in: ... Retrieved July 2011 http://spinwarp.ucsd.edu/neuroweb/Text/br-300b.htm Lewis RB (2010). "Pancreatic Endocrine Tumors: ... Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung ...
... gastric and colorectal carcinoma or lung cancer. Also, CXCL1 is secreted by human melanoma cells, has mitogenic properties and ... Schumacher C, Clark-Lewis I, Baggiolini M, Moser B (November 1992). "High- and low-affinity binding of GRO alpha and neutrophil ... Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M (May 1990). "Neutrophil-activating properties of the melanoma growth- ... Chen X, Jin R, Chen R, Huang Z (2018-02-01). "Complementary action of CXCL1 and CXCL8 in pathogenesis of gastric carcinoma". ...
El-Torkey, M; Giltman, LI; Dabbous, M (1985). "Collagens in scar carcinoma of the lung". The American Journal of Pathology. 121 ... Alberts, B; Johnson, A; Lewis, J (2008). Molecular Biology of the Cell (5th ed.). Garland Science, Taylor & Francis Group. pp. ... malignant melanoma Desmoplastic squamous cell carcinoma Morpheaform basal cell carcinoma Microcystic adnexal carcinoma ... Invasive ductal carcinomas of the breast often have a scirrhous, stellate appearance caused by desmoplastic formations. ...
Pierre Demondiona, Pierre Validireb, Jean Trédanielc ja Dominique Gossota, Thymic metastasis from lung carcinoma, Interact ... Julius M. Cruse, MD, PhD, Robert E. Lewis, "Atlas of Immunology", 3.trükk, CRC Press, lk 807, 2010, (vaadatud 28.09.2014) ... Sajjad Y, Quenby S, Nickson P, Lewis-Jones DI, Vince G., Androgen receptors are expressed in a variety of human fetal ... VICTOR C. JACOBSON, M.D., PRIMARY CARCINOMA OF THE THYMUS, juuni 1923, 31. väljaanne, nr 6, Arch Intern Med (Chic). 1923;31(6): ...
Ma, Yukui; Jia, Yuping; Chen, Lichan; Ezeogu, Lewis; Yu, Baofa; Xu, Ningzhi; Liao, D. Joshua (1 September 2015). "Weaknesses ... Lung Cancer: Targets and Therapy. 6: 1-11. doi:10.2147/LCTT.S70679. PMC 5217516. PMID 28210146. Bu, Jieqiong; Yu, Baofa (Oct ... Journal of Hepatocellular Carcinoma. 2: 57-68. doi:10.2147/JHC.S80756. PMC 4918285. PMID 27508195. Yu, Baofa; Lu, Yuanfei; Gao ... Lung Cancer: Targets and Therapy. 6: 1-11. doi:10.2147/LCTT.S70679. PMC 5217516. PMID 28210146. Gao, Feng; Jing, Peng; Liu, ...
Also, the fucosylated triantennary N-glycans were shown to have the fucose as part of a so-called Sialyl Lewis x epitope, which ... However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury occurs. Further study is currently ... Rudnick DA, Perlmutter DH (September 2005). "Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in ... This involves inhaling purified human A1AT into the lungs and trapping the A1AT into the lower respiratory tract. ...
Ben-Ami R, Lewis RE, Kontoyiannis DP (August 2010). "Enemy of the (immunosuppressed) state: an update on the pathogenesis of ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... "Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment". Environmental Health Perspectives. 118 (6): ... People at higher risk for mold allergies are people with chronic lung illnesses, which will result in more severe reactions ...
"Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density ... 2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV. The GEC ESTRO handbook of brachytherapy. Belgium ... Arnon J, Meirow D, Lewis-Roness H, Ornoy A (2001). "Genetic and teratogenic effects of cancer treatments on gametes and embryos ... For example: non-melanoma skin cancer, head and neck cancer, breast cancer, non-small cell lung cancer, cervical cancer, anal ...
The oligosaccharide sialylated Lewis x (sLe(x)) is expressed on the surface of tumor cells and can be recognized by E-selectin ... Varki NM, Varki A (2002). "Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma ... first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung". ... "Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis" ...
They are associated with central nervous system involvement, kidney disease, lung fibrosis and pericarditis in SLE, but they ... Originally started a laryngeal carcinoma strain, the cell line was contaminated and displaced by HeLa cells, and has now been ... Deshmukh, US; Bagavant, H; Lewis, J; Gaskin, F; Fu, SM (November 2005). "Epitope spreading within lupus-associated ... Around 20-40% of polymyositis is positive for Jo-1 antibodies and most will have interstitial lung disease, HLA-DR3 and HLA- ...
Further investigation with this substance revealed that it could interfere with the LT receptors in the lung carcinoma [38]. In ... Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL, Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse ... Zeegers MP, Jellema A, Ostrer H (2003). "Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: ... men after lung cancer. In the United Kingdom it is also the second most common cause of cancer death after lung cancer, where ...
In oncology: for a carcinoma, in situ means that malignant cells are present as a tumor but have not metastasized, or invaded, ... This can happen anywhere in the body, such as the skin, breast tissue, or lung. This type of tumor can often, depending on ... Lewis & Short Latin Dictionary *^ Collins Latin Dictionary & Grammar *^ Byers, Steven (2011). Introduction to Forensic ...
Alox5 gene knockout mice exhibit an increase in the lung tumor volume and liver metastasis of Lewis lung carcinoma cells that ... reduces growth and progression of the Lewis carcinoma by recruiting cancer-inhibiting CD4+ T helper cells and CD8+ T Cytotoxic ... Setileuton (MK-0633) has completed a Phase II clinical trial for the treatment of asthma, chronic obstructive lung disease, and ... lung, ovary, and pancreas. ALOX5 may be overexpressed in some of these cancers; 5-Oxo-ETE and to a lesser extent 5-HETE ...
Lung cancer. Cyclophosphamide, doxorubicin, vincristine,. CAV. Colorectal cancer. 5-fluorouracil, folinic acid, oxaliplatin. ... Arnon J, Meirow D, Lewis-Roness H, Ornoy A (2001). "Genetic and teratogenic effects of cancer treatments on gametes and embryos ... Colorectal, lung, ovarian and brain cancer. 3. $6.56 billion. Trastuzumab. Herceptin. Roche. Breast, esophagus and stomach ... Isolated limb perfusion (often used in melanoma),[61] or isolated infusion of chemotherapy into the liver[62] or the lung have ...
A squamous-cell carcinoma (the whitish tumor) near the bronchi in a lung specimen ... Alberts B, Johnson A, Lewis J, et al. (2002). "The Preventable Causes of Cancer". Molecular biology of the cell (4th ed.). New ... "Lung Cancer Screening". U.S. Preventive Services Task Force. 2004. Archived from the original on 4 November 2010.. ... "European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel". Ca. 48 (3): 167-76, discussion ...
... hepatocellular carcinoma, pancreatic cancer), ovarian, hematologic or lung malignancies. ... Herbert, Georgia; Perry, Rachel; Andersen, Henning Keinke; Atkinson, Charlotte; Penfold, Christopher; Lewis, Stephen J.; Ness, ... of those with lung or gastrointestinal diseases and who have recently had surgery.[51] According to data in the UK using the ...
Lung, M. S; Trainer, A. H; Campbell, I; Lipton, L (2015). "Familial colorectal cancer". Internal Medicine Journal. 45 (5): 482- ... Soberman, R. J; Harper, T. W; Betteridge, D; Lewis, R. A; Austen, K. F (1985). "Characterization and separation of the ... "Characterization of a 15-Lipoxygenase in Human Breast Carcinoma BT-20 Cells: Stimulation of 13-HODE Formation by TGFα/EGF". ... In guinea pigs, 13(S)-HODE, when injected intravenously, causes a narrowing of lung airways and, when inhaled as an aerosol, ...
Smoking can be linked to all subtypes of lung cancer. Small Cell Lung Carcinoma (SCLC) is the most closely associated with ... Ward C, Lewis S, Coleman T (May 2007). "Prevalence of maternal smoking and environmental tobacco smoke exposure during ... "Benefits of Quitting - American Lung Association". Stop Smoking. American Lung Association. Retrieved 2012-05-06.. ... "Smoking and carcinoma of the lung. Preliminary report", by Richard Doll and Austin Hill,[235][13] and the 1950 Wynder and ...
A squamous-cell carcinoma (the whitish tumor) near the bronchi in a lung specimen ... Kleinsmith, Lewis J. (2006). Principles of cancer biology. Pearson Benjamin Cummings. ISBN 978-0-8053-4003-7. .. ... "Lung Cancer Screening". U.S. Preventive Services Task Force. 2004.. *↑ "Screening for Prostate Cancer". U.S. Preventive ... "European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel". CA Cancer J Clin. 48 (3): 167-76 ...
Pierre Demondiona, Pierre Validireb, Jean Trédanielc ja Dominique Gossota, Thymic metastasis from lung carcinoma, Interact ... Julius M. Cruse, MD, PhD, Robert E. Lewis, "Atlas of Immunology", 3.trükk, CRC Press, lk 807, 2010, (vaadatud 28.09.2014) ... Sajjad Y, Quenby S, Nickson P, Lewis-Jones DI, Vince G., Androgen receptors are expressed in a variety of human fetal ... VICTOR C. JACOBSON, M.D., PRIMARY CARCINOMA OF THE THYMUS, juuni 1923, 31. väljaanne, nr 6, Arch Intern Med (Chic). 1923;31(6): ...
... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ... Usman Ali, M; Miller, J; Peirson, L; Fitzpatrick-Lewis, D; Kenny, M; Sherifali, D; Raina, P (August 2016). "Screening for lung ... Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... Lung cancer, also known as lung carcinoma,[7] is a malignant lung tumor characterized by uncontrolled cell growth in tissues of ...
2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV (eds.). The GEC ESTRO handbook of brachytherapy. ... For example, non-melanoma skin cancer, head and neck cancer, breast cancer, non-small cell lung cancer, cervical cancer, anal ... Arnon J, Meirow D, Lewis-Roness H, Ornoy A (2001). "Genetic and teratogenic effects of cancer treatments on gametes and embryos ... In the treatment of nasopharyngeal, oropharyngeal and hypopharyngeal carcinomas VMAT provides equivalent or better OAR ...
非小細胞癌(NSCLC)可粗分為三大類:肺腺癌、鱗狀上皮癌(英语:squamous-cell lung carcinoma),和大細胞癌(英语:large-cell lung carcinoma)[1]。 ... Usman Ali M, Miller J, Peirson L, Fitzpatrick-Lewis D, Kenny M, Sherifali D, Raina P. Screening for lung cancer: A systematic ... 非小细胞肺癌(英语:Non-small-cell lung carcinoma). *肺鳞癌(英语:Squamous cell lung carcinoma) ... Lung Carcinoma: Tumors of the Lungs. Merck Manual Professional
... involving a reduced lung volume.[26] Other associated lung conditions include pneumonitis, chronic diffuse interstitial lung ... Somers EC, Marder W, Cagnoli P, Lewis EE, DeGuire P, Gordon C, et al. (2014). "Population-based incidence and prevalence of ... Lungs. Inflammation of the pleurae known as pleurisy can rarely give rise to shrinking lung syndrome.[25] SLE can cause ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ...
PET/CT of a staging exam of colon carcinoma. Besides the primary tumor a lot of lesions can be seen. On cursor position: lung ... Lewis DR, Chen HS, Feuer EJ, Cronin KA. SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations). Bethesda, MD: ... "TNM staging of colorectal carcinoma (AJCC 8th edition)". www.pathologyoutlines.com. Retrieved 2019-02-24.. ... If there are only a few metastases in the liver or lungs they may also be removed. Sometimes chemotherapy is used before ...
Normally, they would exit the heart through the pulmonary artery and be stopped by the lungs.) This form of bubble contrast ... Contrast-enhanced renal ultrasonograph, showing a renal cell carcinoma successfully treated with thermal ablation, as no ... In vitro assessment of endothelial dysfunction and multi-targeting to ICAM-1 and sialyl Lewis(x)". Biotechnol. Bioeng. 92: 780- ...
"European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel". CA Cancer J Clin 48 (3): 167-76; ... Kleinsmith, Lewis J. (2006). Principles of cancer biology. Pearson Benjamin Cummings. ISBN 978-0-8053-4003-7. http://books. ... Displazija - Carcinoma in situ - Invazivni rak - Metastaze. Topografija. Anus - Mokraćni mjehur - Krv - Žučni kanal - Kost - ... Lung Cancer Panel". CA: a cancer journal for clinicians 48 (3): 167-76; discussion 164-6. PMID 9594919. doi:10.3322/canjclin. ...
Lewis rat[edit]. The Lewis rat was developed by Margaret Lewis from Wistar stock in the early 1950s. Characteristics include ... mammary gland tumors and endometrial carcinomas in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumors ... "Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by ... Shaking rat Kawasaki was first described in 1988.[36] This and the Lewis rat are well-known stocks developed from Wistar rats. ...
Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L (April 2003). "Cathepsin D specifically cleaves the chemokines ...
Chimney sweeps' carcinoma. *Chronic solvent-induced encephalopathy. *Coalworker's pneumoconiosis ("black lung"). *Concussions ...
Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, colloid carcinomas, ... Typical sites for metastatic spread (stage IV disease) are the liver, peritoneal cavity and lungs, all of which occur in 50% or ... However, it lacks sensitivity and specificity, not least because 5% of people lack the Lewis (a) antigen and cannot produce ... undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast-like giant cells. Solid pseudopapillary tumor is a ...
Spence, Lewis (2003). Encyclopedia of Occultism & Parapsychology Vol. 2. Kessinger Publishing Co. p. 750. ISBN 978-0-7661-2817- ... Psychic surgery made U.S. tabloid headlines in March 1984 when entertainer Andy Kaufman, diagnosed with large cell carcinoma (a ... Kaufman died from renal failure as consequence of a metastatic lung cancer, on May 16, 1984.[18] ... rare lung cancer), traveled to the Philippines for a six-week course of psychic surgery.[16] Practitioner Jun Labo claimed to ...
Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A ... Lidbury, Brett A.; Kita, Badia; Lewis, Donald P.; Hayward, Susan; Ludlow, Helen; Hedger, Mark P.; de Kretser, David M. (2017-01 ... "Activins and activin antagonists in hepatocellular carcinoma". World Journal of Gastroenterology. 14 (11): 1699-709. doi ... "Activin and follistatin in liver biology and hepatocellular carcinoma". SciTopics. Elsevier. Archived from the original on 9 ...
Lewis lung carcinoma is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was ... Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer ... In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. Lewis lung ... implanting a Lewis lung carcinoma into the lung of another C57BL mouse). Because of this fidelity to mimicking the tumor ...
Lewis Lung" by people in Harvard Catalyst Profiles by year, and whether "Carcinoma, Lewis Lung" was a major or minor topic of ... Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL ... "Carcinoma, Lewis Lung" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Carcinoma, Lewis Lung*Carcinoma, Lewis Lung. *Lewis Lung Carcinoma. *Lung Carcinoma, Lewis ...
... Oncol Rep. 2013 Feb;29(2):481- ... However, little is known about evodiamine-induced autophagy in Lewis lung carcinoma (LLC) cells. In this study, LLC cells and a ... Carcinoma, Lewis Lung / drug therapy * Carcinoma, Lewis Lung / genetics * Carcinoma, Lewis Lung / metabolism* ...
Overall, our results demonstrated that miR-21a enriched in lung carcinoma cell-derived exosomes could promote functional ... In addition, our data showed that exosomes derived from human lung cancer cell lines expressing miR-21a, also induced expansion ... However, studies on the molecular mechanism underlying MDSC expansion induced by exosomes from lung cancer cells are still ... In patients with lung cancer, myeloid-derived suppressor cells (MDSCs) have been reported to be significantly increased. Tumor- ...
... line established from the lung of a C57BL mouse bearing a tumor resulting from an implantation of primary Lewis lung carcinoma ...
... we examined the underlying molecular mechanism of luteolin and its effect on in vivo tumor growth of Lewis lung carcinoma (LLC ... and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma ... and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma ... Carcinoma, Lewis Lung/drug therapy. *Carcinoma, Lewis Lung/enzymology*. *Carcinoma, Lewis Lung/pathology* ...
Our study shows that the growth kinetics of Lewis lung carcinoma and dissemination of tumor are dynamically similar to chaotic ... Conclusion In the research of animals with Lewis lung carcinoma was shown, that mechano- magnetochemically synthesized ... oxide and DOXO on nonlinear dynamics of the growth during treatment by of Lewis lung carcinoma. Materials and methods. ... The Effect of Anticancer Nanotherapy on Lewis Lung Carcinoma. V.E. Orel, A.D. Shevchenko, N.A. Nikolov, N.N. Dzyatkovskya, A.V ...
MMP-9 involves radiation-enhanced in vitro invasiveness and in vivo pulmonary metastasis of Lewis lung carcinoma Jason Chia- ... This study is to clarify whether MMP associates with radiation-accelerated pulmonary metastasis of Lewis lung carcinoma (LLC-LM ... MMP-9 involves radiation-enhanced in vitro invasiveness and in vivo pulmonary metastasis of Lewis lung carcinoma ... MMP-9 involves radiation-enhanced in vitro invasiveness and in vivo pulmonary metastasis of Lewis lung carcinoma ...
A549 (CCL-185), Lewis lung carcinoma (LLC; CRL-1642), and HeLa (CCL-2) cell line were obtained from ATCC. MDA-MB-231 and HEK- ... The transfection efficiency was evaluated in Lewis lung carcinoma (LLC) cell lines cultured in vitro and in orthotopic cancer ... AT2R Gene Delivered by Condensed Polylysine Complexes Attenuates Lewis Lung Carcinoma after Intravenous Injection or ... AT2R Gene Delivered by Condensed Polylysine Complexes Attenuates Lewis Lung Carcinoma after Intravenous Injection or ...
Decrease of Metastatogenic Potential by Pregraft Treatment of Lewis Lung Carcinoma Cells with Proteinase and Protein Kinase ... Decrease of Metastatogenic Potential by Pregraft Treatment of Lewis Lung Carcinoma Cells with Proteinase and Protein Kinase ... Decrease of Metastatogenic Potential by Pregraft Treatment of Lewis Lung Carcinoma Cells with Proteinase and Protein Kinase ... Decrease of Metastatogenic Potential by Pregraft Treatment of Lewis Lung Carcinoma Cells with Proteinase and Protein Kinase ...
Data for tumor model Lewis Lung Carcinoma (intramuscular) in B6D2F1 (BDF1) mice. ...
A549 (human lung adenocarcinoma cell line), Lewis lung carcinoma (LLC, a mouse lung cancer cell line), and MRC-5 (normal human ... Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-κB Activities in A549 and Lewis Lung Carcinoma Cells ... this herb can be used as a valuable tool in the combination therapy of metastatic lung carcinoma and the prevention of lung ... Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC comprises 85% of lung cancers and is divided ...
The pharmacokinetics of 132-hydroxy-bacteriopheophorbide a methyl ester (OH-BPME) was studied on Lewis lung carcinoma bearing ... a methyl ester studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice Author(s): Beate Roeder; Cathrin ...
In vivo percent inhibition of Lewis Lung Carcinoma cell line in mice at 100 mg/Kg per day (p<0.001) compared with NCDAC. ...
We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like ... expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma. Naoki ITANO, Kayoko OGURI, Yuko NAGAYASU, Yuri KUSANO, ... expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma ... expressed in a stroma-inducing clone from a mouse Lewis lung carcinoma ...
METHODS: Mice were implanted with Lewis Lung Carcinoma (LLC) or sham phosphate buffered saline (PBS) at 8 weeks of age. The ... In fact, cancer-cachexia is responsible for up to 40% of cancer related deaths depending on the type of carcinoma. Underlying ... METHODS: Mice were implanted with Lewis Lung Carcinoma (LLC) or sham phosphate buffered saline (PBS) at 8 weeks of age. The ... LOSS IN MUSCLE OXIDATIVE PHENOTYPE IN LEWIS LUNG CARCINOMA-INDUCED CANCER-CACHEXIA ...
Synthetic Phenolic Antioxidant TS-13 Suppresses the Growth of Lewis Lung Carcinoma and Potentiates Oncolytic Effect of ... on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in ... was observed on day 21 after inoculation of Lewis lung carcinoma cells. Two-fold intraperitoneal injections of doxorubicin in a ... reactive oxygen metabolites grafted Leis lung carcinoma sulphur-containing phenolic antioxidant TS-13 ...
LLC1 cell line was established from the lung of a C57BL mouse bearing a tumor of primary Lewis lung carcinoma. This cell line ... LLC1 mouse Lewis lung carcinoma cell line was obtained from the ATCC (Rockville, Maryland, USA). Cells were cultured under ... Mice were injected subcutaneously with Lewis lung carcinoma (LLC1) cells (1x106 cells suspended in RPMI medium) in the right ... To elucidate structural changes in cellular morphology we examined mouse Lewis lung carcinoma LLC1 cells grown under 2D or lr- ...
... against Lewis lung carcinoma (3LL) in C57BL/6 mice was determined. Intrapleural (i.pl.) administration of LC 9018 was effective ... administration of LC 9018 into the mice rendered their lung macrophages tumoricidal for 3LL cells in vitro. These results show ... Anti-tumour activity of Lactobacillus casei on lewis lung carcinoma and line-10 hepatoma in syngeneic mice and guinea pigs. * ... Augmentation of antimetastatic effect on Lewis lung carcinoma (3LL) in C57BL/6 mice by priming with Lactobacillus casei. * ...
METHODS: Fisetin cytotoxicity was evaluated using Lewis lung carcinoma cells (LLC), endothelial cells and NIH 3T3 cells. ... Keywords : flavonoid fisetin cyclophosphamide Lewis lung carcinoma EA⋅hy 926 endothelial cells angiogenesis cytotoxicity ... METHODS: Fisetin cytotoxicity was evaluated using Lewis lung carcinoma cells (LLC), endothelial cells and NIH 3T3 cells. ... and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma- ...
... low-immunogenic D122 clone of the Lewis lung carcinoma with a mammalian expression vector containing the human IL-6 ... In mature T-cell deficient nude mice, the IL-6 transfectants showed some arrest of local growth but no suppression of lung ... Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers ... article{Porgador1992Interleukin6G, title={Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the ...
The objective of this study is to evaluate the role of different concentrations of Lewis lung carcinoma cells (LLC cells) at ... Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign ... The Lewis lung carcinoma (LLC) cells were purchased from the American Type Culture Collection (Manassas, VA, USA) and were ... The objective of this study is to evaluate the role of different concentrations of Lewis lung carcinoma cells (LLC cells) at ...
... fabricated and examined in vitro in Lewis Lung carcinoma (LLC) as a model of non-small cell lung cancer through use of comet ... The presented data aids in the evaluation of the radiobiological response of Lewis Lung carcinoma cells treated with gold ... fabricated and examined in vitro in Lewis Lung carcinoma (LLC) as a model of non-small cell lung cancer through use of comet ... Gold Nanoparticles Radio-sensitize and Reduce Cell Survival in Lewis Lung Carcinoma. Arvind Pandey , Veronica Vighetto , Nicola ...
Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL ...
... including the Lewis lung carcinoma (LLC) model, remains unclear. High and low metastatic LLC variants were generated by ... Despite the extracellular acidity of tumor tissues, the effect of acidic extracellular pH (pH e ) on EMT in carcinoma models, ... can induce EMT in some types of carcinoma. ... epithelial mesenchymal transition in Lewis lung carcinoma model ...
... on murine Lewis lung carcinoma (LL2) cells through in vivo study. As a experimental model, LL2 cells (,TEX,$1{\times}10^{6}$,/ ... on murine Lewis lung carcinoma (LL2) cells through in vivo study. As a experimental model, LL2 cells (. $1{\times}10^{6}$. / ... The anti-tumor effect of combined treatment with arsenic trioxide and interferone-α on transplanted murine Lewis lung carcinoma ... Arsenic trioxide-induced apoptosis and its enhancement by buthionine sulfoximine in hepatocellular carcinoma cell lines. ...
In addition, white blood cell (WBC) counts and H&E-stained sections of liver, lungs, kidney, and heart were performed in order ... Endo significantly enhanced anti-tumor and anti-angiogenic responses without overt toxicity in a xenograft model of human lung ... Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic ... The murine Lewis lung carcinoma (LLC) cell line was purchased from the cell resource center of Shanghai institute of life ...
To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions. ... Impact of lactic acidosis on the survival of Lewis lung carcinoma cells. Kolesnik D.L.*, Pyaskovskaya O.N., Solyanik G.I. ... In the work, LLC/R9 variant of Lewis lung carcinoma cells was used [8]. Tumor cells are maintained in vitro in complete RPMI ... Materials and Methods: LLC/R9 variant of Lewis lung carcinoma cells was cultured in glucose deficit or complete culture medium ...
... activity of Lewis lung carcinoma. Materials and Methods: Experiments were performed on female mice C57Bl/6 with Lewis lung ... Lewis lung carcinoma, metastases, Nω-hydroxy-nor-arginine, ornithine decarboxylase, polyamine metabolism, α- ... 1. Lewis lung carcinoma growth in mice under the influence of inhibitors of PA metabolism. *Significant difference (p , 0.05) ... Effect of polyamine metabolism inhibitors on Lewis lung carcinoma growth and metastasis. Samoilenko О.А., Milinevska O.A., ...
The study reported on in this article is a systematic search for the genetic networks underlying the Lewis lung carcinoma (LLC ... Lung cancer is the most common human cancer. There are numerous studies that have sought to discover genetic impact factors ... Lewis lung carcinoma is a tumor named after its 1951 discoverer, Dr. Margaret R. Lewis, of the Wistar Institute. Worldwide lung ... A Network-Based, Genetic-Marker Evaluation for Lewis Lung Carcinoma. Xiangyao Lian1, Dexiang Yang2, Shaolong Cao3* ...
  • Generally, Lewis lung carcinoma is highly metastatic in immunocompetent mice. (wikipedia.org)
  • If subcutaneously injected into mice, it is known to avidly metastasize to the lung. (wikipedia.org)
  • Navelbine and carboplatin, two chemotherapeutics currently on the market, were tested in C57BL mice with Lewis lung carcinoma tumors in their hind flank. (wikipedia.org)
  • Targeting of CD169+ macrophages in order to inhibit tumor Lewis lung carcinoma growth also caused depletion of bone and bone marrow in mice. (wikipedia.org)
  • The transfection efficiency was evaluated in Lewis lung carcinoma (LLC) cell lines cultured in vitro and in orthotopic cancer grafts in syngeneic mice. (aacrjournals.org)
  • Three synthetic irreversible enzyme inhibitors (75 µ m di-isopropylphosphorofluoridate (DFP), 310 µ m Nα-p-tosyl-L-lysine (TLCK) and 240 µ m L-1-tosylamide-2-phenylethyl (TPCK) chloromethyl ketone), as well as the transition state analogue chymostatin, inhibit the development of Lewis lung adenocarcinoma (3LL) in C57 Bl/6 mice, when 3LL cells are treated once and for a limited period (60 min) prior to grafting. (aacrjournals.org)
  • The pharmacokinetics of 13 2 -hydroxy-bacteriopheophorbide a methyl ester (OH-BPME) was studied on Lewis lung carcinoma bearing mice by fluorescence spectroscopy. (spie.org)
  • METHODS: Mice were implanted with Lewis Lung Carcinoma (LLC) or sham phosphate buffered saline (PBS) at 8 weeks of age. (wku.edu)
  • The effects of a synthetic phenolic antioxidant sodium 3-(3'-tert-butyl-4'-hydroxyphenyl)propyl thiosulfonate sodium (TS-13) on the tumor growth and oncolytic properties of doxorubicin were studied in the experimental model of Lewis lung carcinoma in mice. (springer.com)
  • In mice receiving TS-13 with drinking water (100 mg/kg), suppression of tumor growth by 32.3% was observed on day 21 after inoculation of Lewis lung carcinoma cells. (springer.com)
  • The antimetastatic effect of Lactobacillus casei YIT9018 (LC 9018) against Lewis lung carcinoma (3LL) in C57BL/6 mice was determined. (semanticscholar.org)
  • Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice. (inserm.fr)
  • Experiments were performed on female mice C57Bl/6 with Lewis lung carcinoma. (exp-oncology.com.ua)
  • The aim of this work was to study the effect of inhibitors of PA metabolism on the growth and metastasis of experimental Lewis lung carcinoma in mice. (exp-oncology.com.ua)
  • Lapis, K , Repasy, G & Kiraly, K 1978, ' The effect of retinoic acid on lewis lung carcinoma model in mice: A preliminary note ', Dermatology , vol. 157, no. (elsevier.com)
  • Two dimethyltriazenoimidazoles, DTIC and BRL 51308, and a benzenoid dimethyltriazene, CB 10286, have been examined for their effects in mice bearing Lewis lung carcinoma. (uthscsa.edu)
  • Implantation of a fast-growing tumor to mice (Lewis lung carcinoma) resulted in a clear cachectic state characterized by a profound muscle wasting. (lu.se)
  • In this report, we evaluated the efficacy of a GM-CSF-producing tumor vaccine given before and after docetaxel in mice bearing established lung tumors. (elsevier.com)
  • Objective To investigate the effect of Toxoplasma gondii excretory-secretory antigens (ESA) on CD4+ CD25+ Foxp3+ T (Treg) cells in mice carrying Lewis lung carcinoma , and examine the inhibitory effect of T. gondii ESA on tumor growth . (bvsalud.org)
  • Methods C57BL/6 mice were randomly assigned into the PBS group (n = 14) and the Lewis group (n = 34). (bvsalud.org)
  • Mice in the Lewis group were subcutaneously injected with 2 × 105 Lewis lung carcinoma cells in the right axilla , while animals in the PBS group were injected with the same volume of sterile PBS. (bvsalud.org)
  • On day 7 post- injection (D7), mice in the PBS group were further divided into the PBS2 group and the PBS2 + ESA group, of 7 mice in each group, and mice in the Lewis group were further divided into the Lewis2 group and the Lewis2 + ESA group, of 17 mice in each group. (bvsalud.org)
  • Conclusion T. gondii ESA may reduce the proportion of splenic Treg cells in splenocytes and inhibit tumor growth in mice carrying Lewis lung carcinoma . (bvsalud.org)
  • Metastatis was likewise decreased and 25% of the mice had healthy lungs. (elsevier.com)
  • Mice treated with LPS or implanted with the Lewis lung carcinoma (LLC) robustly increase the expression of inflammatory cytokines in the hypothalamus ( Fig. 1, a and c ). (rupress.org)
  • Phyllanthus urinaria has anti-tumor and anti-angiogenic effects in mice bearing Lewis lung carcinoma. (greenmedinfo.com)
  • Metastatic establishment and growth of Lewis lung carcinoma is promoted by single-walled carbon nanotube s (SWCNT) in C57BL6/J mice. (cdc.gov)
  • The effects of FK317 (11-acetyl-8-carbamoyloxymethyl-4-formyl-6-methoxy-14- oxa-1,11-diazatraacylo[7.4.1.0(2.7).0(10.2)]-tetradeca-2,4,6-trien-9-yl acetate), a novel anti-cancer agent, and mitomycin C (MMC) on survival time of mice bearing B16BL6 melanoma and Lewis lung carcinoma (LLC), induced by intravenous inoculation of the tumor, were investigated. (eurekamag.com)
  • This fraction, alone and in conjunction with chemotherapy drugs, is able to increase the survival of laboratory mice that have been implanted with lung cancer. (mskcc.org)
  • Experiments were performed on CBA mice with subcutaneously transplanted cervical carcinoma. (spiedigitallibrary.org)
  • 1984) Photoradiation therapy of Lewis lung tumors in mice with low optical dose rat and high HpD-dose. (ntnu.edu)
  • 1983) Photoradiation Therapy (PRT) of Lewis Lung Carcinoma in B6D2 Mice, Dosimetry Considerations. (ntnu.edu)
  • C-X-C--Chemokine, Is an Angiogenesis Inhibitor That Suppresses the Growth of Lewis Lung Carcinoma in Mice", J. Exp. (patentgenius.com)
  • MISR mice showed resistance to muscle loss caused by either denervation or injection of Lewis lung carcinoma cells. (sciencemag.org)
  • However, little is known about evodiamine-induced autophagy in Lewis lung carcinoma (LLC) cells. (nih.gov)
  • In patients with lung cancer, myeloid-derived suppressor cells (MDSCs) have been reported to be significantly increased. (nature.com)
  • However, studies on the molecular mechanism underlying MDSC expansion induced by exosomes from lung cancer cells are still limited. (nature.com)
  • Yuan XK, Zhao XK, Xia YC, Zhu X, Xiao P. Increased circulating immunosuppressive CD14(+)HLA-DR(-/low) cells correlate with clinical cancer stage and pathological grade in patients with bladder carcinoma. (nature.com)
  • Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. (nature.com)
  • Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. (nih.gov)
  • In the present study, we examined the underlying molecular mechanism of luteolin and its effect on in vivo tumor growth of Lewis lung carcinoma (LLC) cells. (nih.gov)
  • V. yedoensis extracts (VYE) can suppress the invasion of a highly metastatic human lung cancer cell line, A549 cells. (medsci.org)
  • VYE also suppressed the DNA binding activity of nuclear factor-kappa B. We concluded that VYE may inhibit tumor invasion by suppressing the activities of MMP and u-PA in lung cancer cells. (medsci.org)
  • Lung carcinoma, which develops from epithelial cells, is the most commonly diagnosed malignancy and the main cause of cancer-related deaths in Asian and Western countries with only approximately 15% chance of a 5-year survival rate [ 6 ]. (medsci.org)
  • We previously reported that a mouse Lewis lung carcinoma-derived stroma-inducing clone, P29, highly expresses a syndecan-like proteoglycan exhibiting specific binding to fibronectin, a major constituent of the interstitial matrix formed by the induced stromal cells, via its heparan sulphate chains [Itano, Oguri, Nakanishi and Okayama (1993) J. Biochem. (biochemj.org)
  • METHODS: Fisetin cytotoxicity was evaluated using Lewis lung carcinoma cells (LLC), endothelial cells and NIH 3T3 cells. (inserm.fr)
  • Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells. (semanticscholar.org)
  • To investigate the influence of interleukin 6 (IL-6) production on malignancy of tumor cells we transfected cells of the high-metastatic, low-immunogenic D122 clone of the Lewis lung carcinoma with a mammalian expression vector containing the human IL-6 complementary DNA. (semanticscholar.org)
  • The objective of this study is to evaluate the role of different concentrations of Lewis lung carcinoma cells (LLC cells) at the time of induction of experimental MPE and the main effects on survival of animals. (biomedcentral.com)
  • The Lewis lung carcinoma (LLC) cells were purchased from the American Type Culture Collection (Manassas, VA, USA) and were cultured at 37 °C in 5 % CO 2 − 95 % air using Dulbecco's modiWed Eagle's medium (DMEM) with 10 % fetal bovine serum. (biomedcentral.com)
  • The presented data aids in the evaluation of the radiobiological response of Lewis Lung carcinoma cells treated with gold nanoparticles. (preprints.org)
  • In the present study, we expected the anti-tumor effect by combined treatment of arsenic trioxide and interferon (IFN)- ${\alpha}$ on murine Lewis lung carcinoma (LL2) cells through in vivo study. (koreascience.or.kr)
  • To investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under glucose-deprived conditions. (exp-oncology.com.ua)
  • LLC/R9 variant of Lewis lung carcinoma cells was cultured in glucose deficit or complete culture medium. (exp-oncology.com.ua)
  • Lactic acidosis promoted the survival and proliferation of Lewis lung carcinoma cells by energy system reprogramming directed on inhibition of apoptosis and autophagy, a significant decrease in the rate of glucose utilization and activation of glutaminolysis and, consequently, increase of the lactate production rate. (exp-oncology.com.ua)
  • The aim of the work was to investigate the effect of lactic acidosis on the survival of Lewis lung carcinoma cells under conditions of metabolic stress induced by glucose deprivation. (exp-oncology.com.ua)
  • In the work, LLC/R9 variant of Lewis lung carcinoma cells was used [8]. (exp-oncology.com.ua)
  • In clonogenic and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays as well as in the in vivo Lewis lung carcinoma mouse tumor model, pentamidine is shown to possess the ability to selectively kill cancer cells. (aacrjournals.org)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) has not been found to exert any influence on the proliferation of Lewis lung carcinoma (LLC) cells in vitro. (elsevier.com)
  • Lewis lung carcinoma cells contain specific high-affinity binding sites for the eicosanoid 12( S )-hydroxy-5,8,10,14-eicosatetraenoic acid [12( S )-HETE]. (pnas.org)
  • The antibody detected CKAP4 in lung cancer tissue and tumor cells. (medicalnewstoday.com)
  • Lewis Lung Carcinoma cells (also known as 3LL cells or LLC cells) got their name after Dr. Margaret R. Lewis of the Wistar Institute, who discovered carcinoma in 1951. (altogen.com)
  • These cells could be useful for medical research for treatments to certain types of lung cancer, and many other molecular or cell biology studies. (altogen.com)
  • Furthermore, pericytes in RIP-Tag2 tumors, as well as those in MCa-IV breast carcinomas and Lewis lung carcinomas, had an abnormally loose association with endothelial cells and extended cytoplasmic processes deep into the tumor tissue. (nih.gov)
  • In this study, to clarify the role of E-units in the metastasis and to search for potential molecular targets for anticancer drugs, the isolation and characterization of Lewis lung carcinoma (LLC) cells stably downregulated by the knockdown for the gene encoding N -acetylgalactosamine 4- O -sulfate 6- O -sulfotransferase (GalNAc4S-6ST), which is responsible for the formation of E-units in CS chains, were performed. (hindawi.com)
  • Furthermore, the stable downregulation of GalNAc4S-6ST expression in LLC cells markedly inhibited the colonization of the lungs by inoculated LLC cells and invasive capacity of LLC cells. (hindawi.com)
  • To address this question we explored miRNA expression patterns in mouse Lewis lung carcinoma LLC1 cells growing in laminin rich ECM microenvironment. (datamed.org)
  • 2012. Properties of Lewis lung carcinoma cells surviving curcumin toxicity. (bgsu.edu)
  • Carbon nanotube s enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. (cdc.gov)
  • Lewis lung carcinoma cells express a plasma membrane receptor (i.e. (rti.org)
  • Squamous cell cancer affects the cells that line the airway and cells in the middle of the lungs, according to the ACS. (drugs.com)
  • Cancer cells from different types of cancer (i.e. breast vs lung vs liver) and even those from the same patient can be very different from each other. (cancerquest.org)
  • It may also have activity against cancer cells and may shrink tumor size, particularly with lung or skin cancers. (webmd.com)
  • According to a 2015 review article, Lewis lung carcinoma is the only reproducible syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. (wikipedia.org)
  • The Lewis lung carcinoma tumor model's role in cancer has been its use for research into tumor metastasis and angiogenesis properties. (wikipedia.org)
  • Toll-like receptor 4 mediates cancer-induced muscle wasting in a Lewis lung carcinoma model. (wikipedia.org)
  • Hao Y, Yasmin-Karim S, Moreau M, Sinha N, Sajo E, Ngwa W. Enhancing radiotherapy for lung cancer using immunoadjuvants delivered in situ from new design radiotherapy biomaterials: a preclinical study. (harvard.edu)
  • Takahashi Y, Izumi Y, Matsutani N, Dejima H, Nakayama T, Okamura R, Uehara H, Kawamura M. Optimized magnitude of cryosurgery facilitating anti-tumor immunoreaction in a mouse model of Lewis lung cancer. (harvard.edu)
  • In addition, our data showed that exosomes derived from human lung cancer cell lines expressing miR-21a, also induced expansion of MDSCs in human CD14 + monocytes in vitro. (nature.com)
  • Fig. 8: Exosomes derived from human lung cancer cell lines trigger expansion of human MDSCs. (nature.com)
  • This simple nonviral formulation approach showed negligible cytotoxicity in four different human cell lines (cervix, breast, kidney, and lung cell lines) and one mouse cell line (a lung cancer cell line). (aacrjournals.org)
  • A single administration of these complexes markedly attenuated lung cancer growth, offering preclinical proof-of-concept for a novel nonviral gene delivery method exhibiting effective lung tumor gene therapy via either intravenous or intratracheal administration. (aacrjournals.org)
  • Even though progress has been made in early detection and prevention, mortality, and morbidity associated with lung cancer is still unacceptably high ( 3 ). (aacrjournals.org)
  • 430,000 people in the United States are living with lung cancer yielding the largest annual financial burden of any cancer type ( 1 ). (aacrjournals.org)
  • Theoretical, and practical limitations still exist for gene therapy application to lung cancer. (aacrjournals.org)
  • Biologic barriers and toxicity continue to confound lung cancer treatment, even though the lungs may be accessed via inhalation or intravenous administration. (aacrjournals.org)
  • Metastasis is the main cause of death in patients with lung cancer. (medsci.org)
  • Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. (medsci.org)
  • Cancer metastasis and drug resistance are two principal causes for the poor survival and prognosis of patients with lung cancer [ 7 ]. (medsci.org)
  • In fact, cancer-cachexia is responsible for up to 40% of cancer related deaths depending on the type of carcinoma. (wku.edu)
  • Immunotherapy of lung cancer]. (semanticscholar.org)
  • Approximately 15 % of lung cancer patients present pleural effusion at the time of diagnosis and half of them develop pleural effusion at disease advanced stages [ 1 - 5 ]. (biomedcentral.com)
  • The purpose of this study was to compare the potential radio-sensitization effects of two different sized GNPs (3.9 and 37.4 nm) fabricated and examined in vitro in Lewis Lung carcinoma (LLC) as a model of non-small cell lung cancer through use of comet and clonogenic assays. (preprints.org)
  • Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. (biomedcentral.com)
  • These results indicated that MET NVB combined with Endo significantly enhanced anti-tumor and anti-angiogenic responses without overt toxicity in a xenograft model of human lung cancer. (biomedcentral.com)
  • Lung cancer is one of the most commonly diagnosed malignant tumors and non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all lung cancer diagnosis. (biomedcentral.com)
  • Lung cancer exhibits a high rate of mortality and is often not diagnosed at an early stage. (biomedcentral.com)
  • Lung cancer is the most common human cancer. (hapres.com)
  • Worldwide lung cancer is the most common human cancer measured by incidence and mortality [1] . (hapres.com)
  • Lung cancer is one of the most common human malignancies. (pnas.org)
  • Researchers may have found a biomarker for lung cancer, which could soon enable healthcare professionals to detect the disease while it is still in stage 1. (medicalnewstoday.com)
  • Lung cancer is the second most prevalent form of cancer in men and women and the top cancer killer among both sexes. (medicalnewstoday.com)
  • The World Health Organization (WHO) suggest that 1.69 million deaths are brought about by lung cancer worldwide. (medicalnewstoday.com)
  • The main reason behind why lung cancer has such a high mortality rate is that it is often caught at an advanced stage. (medicalnewstoday.com)
  • In fact, around three quarters of people with lung cancer already experience symptoms when they present themselves for a checkup, and, by that point, cancer has usually already spread to other parts of the lungs or elsewhere in the body. (medicalnewstoday.com)
  • We need better biomarkers for early diagnosis," adds Sato, who led a new study that identified a protein that may help to diagnose lung cancer while it is still in stage 1. (medicalnewstoday.com)
  • According to the ACS, the survival rate for individuals whose lung cancer is diagnosed at stage 1 ranges between 68 and 92 percent . (medicalnewstoday.com)
  • In this study, the researchers used the antibody called KU-Lu-1 to see whether or not it would recognize cancer proteins in the blood of 271 people with lung cancer. (medicalnewstoday.com)
  • Sato and team explain the significance of their findings, emphasizing the place of CKAP4 among existing biomarkers for lung cancer. (medicalnewstoday.com)
  • Crucially, the biomarker sensitivity remained high even in stage 1 lung cancer, meaning that CKAP4 blood levels were high in people with this early stage of the disease. (medicalnewstoday.com)
  • The results of our study provide evidence that the CKAP4 protein may be a novel early sero-diagnostic marker for lung cancer," concludes Nagashio. (medicalnewstoday.com)
  • The use of CKAP4 as a biomarker could change current practices regarding the treatment of lung cancer patients, and the diagnostic accuracies may be markedly improved by the combination of CKAP4 and conventional markers. (medicalnewstoday.com)
  • Lung cancer is considered the most preventable malignancy globally. (altogen.com)
  • Further, the expression of a PG, versican, is upregulated in various types of tumors including lung cancer, as a macrophage activator that acts through Toll-like receptor-2 and its co-receptors Toll-like receptor-6 and CD14 [ 10 ]. (hindawi.com)
  • Background: 6-(1-Proproxyiminomethyl)-5,8-dimethoxy-1,4-naphthoquinone S-53 (DMNQ S-53) was synthesized to develop a novel anti-tumor agent against lung cancer. (elsevier.com)
  • This randomized phase III trial studies how well management of a tobacco treatment intervention works in reducing surgical complications in patients with newly diagnosed lung cancer who smoke cigarettes. (centerwatch.com)
  • I. To determine if varenicline plus a behavioral intervention consisting of a brief clinician-delivered intervention and tobacco quitline follow-up, decreases postsurgical complications through 24 weeks after surgery when compared to placebo plus the behavioral intervention in lung cancer patients who undergo surgery and are motivated to stop smoking. (centerwatch.com)
  • DDW was administered as an oral anticancer agent in addition to conventional therapy, and noticeably prolonged the survival time of all 4 lung cancer patients with brain metastasis. (greenmedinfo.com)
  • How is large-cell carcinoma subtype of non-small cell lung cancer (NSCLC) characterized? (medscape.com)
  • Guideline] Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. (medscape.com)
  • Radical radiotherapy for stage I/II non-small cell lung cancer in patients not sufficiently fit for or declining surgery (medically inoperable): a systematic review. (medscape.com)
  • Potentially curative radiotherapy for non-small-cell lung cancer in Norway: a population-based study of survival. (medscape.com)
  • Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. (medscape.com)
  • Nonfilter and filter cigarette consumption and the incidence of lung cancer by histological type in Japan and the United States: analysis of 30-year data from population-based cancer registries. (medscape.com)
  • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. (medscape.com)
  • Nelson R. Lung Cancer Rates Surging in Never-Smokers. (medscape.com)
  • Epidemiology and etiology of lung cancer. (medscape.com)
  • Alcohol consumption and lung cancer risk in never smokers: a meta-analysis. (medscape.com)
  • Ginsberg RJ, Vokes EE, Raben A. Non-small cell lung cancer. (medscape.com)
  • Exposure to environmental tobacco smoke and the risk of lung cancer: a meta-analysis. (medscape.com)
  • The main goal of this study was to provide the "proof-of-principle" that low-dose paclitaxel is able to change the tumor microenvironment and improve the outcome of intratumoral dendritic cell vaccine in a murine lung cancer model. (aacrjournals.org)
  • Lung cancer is the leading cause of cancer-related morbidity and mortality, resulting in more than 160,000 deaths per year in the United States and ∼1.1 million worldwide. (aacrjournals.org)
  • About 80% to 85% of lung cancer cases are non-small-cell lung cancer, and 65% of them have an advanced-stage disease at diagnosis ( 1 , 2 ). (aacrjournals.org)
  • Surgery, chemotherapy, and radiation prolong survival of patients with lung cancer, but the effect is typically temporary and decreased with advanced disease ( 2 - 5 ). (aacrjournals.org)
  • For instance, the low toxicity profile and efficacy of low-dose paclitaxel justified its usage in the group of poor-prognosis elderly patients with lung cancer and as a second-line treatment for advanced lung cancer ( 12 , 13 ). (aacrjournals.org)
  • The limited successes of conventional treatments for patients with lung cancer raised the possibility that a combination therapy may overcome tumor resistance to different treatments. (aacrjournals.org)
  • We determined the antiangiogenic and anticancer activity of VEGI-192, a new isoform of TNFSF15 (VEGI, TL1), with a Lewis lung cancer murine tumor model. (aacrjournals.org)
  • AY434464) using a Lewis lung cancer (LLC) murine tumor model. (aacrjournals.org)
  • 1985). "An analysis of lung cancer risk from exposure to hexavalent chromium. (cdc.gov)
  • Lung cancer mortality among workers making lead chromate and zinc chromate pigments at three English factories. (cdc.gov)
  • Occupational exposure to chromium(VI) compounds has been associated with increased incidence of lung cancer. (cdc.gov)
  • MONDAY, Aug. 11, 2014 -- Overall lung cancer rates are dropping, according to a new analysis of nearly a half million Americans with lung cancer. (drugs.com)
  • But, the news wasn't all good -- the study also found that the rates of certain types of lung cancer are increasing, according to researchers from the U.S. National Cancer Institute (NCI). (drugs.com)
  • Over nearly three decades, the overall lung cancer rate has dropped approximately 12 percent, said the study's lead author Denise Riedel Lewis, an epidemiologist at the NCI. (drugs.com)
  • The good news is that lung cancer rates are declining. (drugs.com)
  • Riedel Lewis said that while she cannot draw a definitive conclusion about what's causing the decline in lung cancer rates, she can infer that it's mostly due to decreases in smoking. (drugs.com)
  • Since 90 to 95 percent of lung cancers in the United States are caused by smoking, these changes in lung cancer rates likely reflect that fewer people are smoking, she said. (drugs.com)
  • One type of lung cancer that's on the rise is called adenocarcinoma, Riedel Lewis said. (drugs.com)
  • Adenocarcinomas account for about 40 percent of all lung cancers, according to the American Cancer Society (ACS). (drugs.com)
  • They tend to grow slower than other types of lung cancer and are more likely to be found before spreading outside the lung. (drugs.com)
  • Dr. Norman Edelman, a senior medical advisor to the American Lung Association, said this type of cancer may be increasing as a result of changes in the way smokers smoke. (drugs.com)
  • The deeper you breathe in smoke, the more likely the cancer-causing tars are going to get into the outer area of the lungs, and that's where adenocarcinoma starts," he said. (drugs.com)
  • Another type of cancer, squamous cell carcinoma, is dropping less rapidly than it has in the past, Riedel Lewis said. (drugs.com)
  • This type of cancer accounts for about 30 percent of all lung cancers. (drugs.com)
  • Small cell lung cancer rates, as well as unspecified lung cancer rates dropped, the researchers found. (drugs.com)
  • Edelman pointed out that gender differences in lung cancer rates are changing. (drugs.com)
  • The rates of lung cancer in men and women are converging -- they are almost the same now. (drugs.com)
  • The rates of lung cancer in men are going down and the rates in women have plateaued. (drugs.com)
  • Edelman also noted that the rates of lung cancer had been growing among women because they took up smoking later than men, so the long-term effects of smoking were delayed compared with men. (drugs.com)
  • The rate of lung cancer among women is not declining, but it will, just as it has in men," he said. (drugs.com)
  • The fewer people who smoke, the fewer people who will get lung cancer, so we have to keep fighting the good fight," Edelman said. (drugs.com)
  • For the study, researchers collected data from more than 450,000 people diagnosed with lung cancer between 1977 and 2010. (drugs.com)
  • For more information on lung cancer, visit the American Cancer Society . (drugs.com)
  • Lung cancer and colorectal cancer are among the most common malignant diseases (3, 4). (thefreelibrary.com)
  • The expression of TF and its isoforms is induced and highly regulated in several types of cancer, i.e., in lung and breast cancer (3, 4, 16). (thefreelibrary.com)
  • Three yeast artificial chromosome (YAC) clones spanning the minimal loss of heterozygosity region were modified, and spheroplast fusion was used to transfer them into human A549 NSCLC or murine Lewis lung carcinoma (LLC) cell lines. (pnas.org)
  • A human lung adenocarcinoma cell line, A549, and the murine Lewis lung carcinoma (LLC) line were obtained from Riken Cell Bank (Tsukuba, Japan) and grown in DMEM (A549) or Eagle's minimal essential medium (LLC) supplemented with 10% fetal bovine serum, penicillin, and streptomycin (GIBCO/BRL) ( 13 ). (pnas.org)
  • Lewis lung carcinoma is a tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. (wikipedia.org)
  • Orthotopic models focus upon correctly modeling the tumor microenvironment by injecting or implanting tumors into the corresponding organ that they originated from (i.e. implanting a Lewis lung carcinoma into the lung of another C57BL mouse). (wikipedia.org)
  • This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. (harvard.edu)
  • ATCC# CLR1642: Cell line established from the lung of a C57BL mouse bearing a tumor resulting from an implantation of primary Lewis lung carcinoma. (thermofisher.com)
  • This study is to clarify whether MMP associates with radiation-accelerated pulmonary metastasis of Lewis lung carcinoma (LLC-LM) in C57BL/6 mouse model. (aacrjournals.org)
  • It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. (wikipedia.org)
  • Tumor strain Lewis lung carcinoma was obtained from National Bank of Cell Lines and Transplanted Tumors of R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobio-logy, NAS of Ukraine (Kyiv, Ukraine). (exp-oncology.com.ua)
  • No significant cytotoxic effect of the triazenes was observed in small established pulmonary tumors, as determined by evaluating the effects of treatment on the fractional incorporation of 3 H-TdR into DNA of the lung colonies. (uthscsa.edu)
  • These cancers are divided by their biological features into two distinct categories: small cell lung carcinoma and nonsmall cell lung carcinoma (NSCLC) ( 1 ). (pnas.org)
  • Methods: Cytotoxicity assay, DNA fragmentation assay, cell cycle analysis, mitochondrial potential measurement and Western blotting were employed in vitro and also Lewis lung carcinoma (LLC) animal model was used for evaluating the anti-tumor of DMNQ S53 in vivo. (elsevier.com)
  • We evaluated the antitumor potential and changes in the intratumoral milieu of a combination of low-dose chemotherapy and dendritic cell vaccine in the Lewis lung carcinoma model in vivo . (aacrjournals.org)
  • NSCLC comprises 85% of lung cancers and is divided into subtypes, such as adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. (medsci.org)
  • 2012. Effect of curcumin on stem-like sub population in human esophageal squamous cell carcinoma cell lines. (bgsu.edu)
  • Taking a specific shark cartilage extract (AE-941) by mouth might increase survival in patients with renal cell carcinoma. (medlineplus.gov)
  • Malignant pleural effusion resulting mainly from pleural metastases of lung adenocarcinoma has clinical relevance, being a sign of poor prognosis and low life expectancy. (biomedcentral.com)
  • Administration of DFMO or it's combination with nor-NOHA resulted in the decrease of tumor growth rate, number and volume of lung metastases and was accompanied with reduced ODC activity in tumor tissue. (exp-oncology.com.ua)
  • In these studies, the number and volume of lung metastases in untreated animals and in animals treated as described above for the tumor growth delay studies were scored on day 26 post-tumor implant. (exp-oncology.com.ua)
  • On the contrary, all the tested compounds sharply reduced the number of lung metastases and also resulted in a high proportion of animals free of metastases at death. (uthscsa.edu)
  • Large-cell carcinoma accounts for 10-15% of lung cancers, typically manifesting as a large peripheral mass on chest radiograph. (medscape.com)
  • Malignant pleural effusion (MPE) resulting from pleural metastasis of lung adenocarcinoma is a common clinical problem with severe implications, since it is a debilitating condition associated with high morbidity, poor prognosis and low life expectancy (3-15 months) [ 1 - 6 ]. (biomedcentral.com)
  • Recent adenocarcinoma rates were higher among young women than among men, Riedel Lewis noted. (drugs.com)
  • In particular, the need for completely new therapeutics to treat the most aggressive lung cancers is especially great. (aacrjournals.org)
  • Most research shows that taking shark cartilage by mouth does not benefit people with advanced, previously treated cancers of the breast, colon, lung, prostate, or brain. (medlineplus.gov)
  • It also treats malignant cancers [2] including head and neck, lung, bladder and particular skin. (wikipedia.org)
  • Lewis lung carcinoma can also be utilized as an orthotopic model. (wikipedia.org)
  • Melittin, a polypeptide found in bee venom, on tumor-associated macrophages has been examined in a Lewis lung carcinoma model. (wikipedia.org)
  • The study reported on in this article is a systematic search for the genetic networks underlying the Lewis lung carcinoma (LLC) model. (hapres.com)
  • Effect of Heparin and Its Derivatives On the Progression of Tumor Growth in Mouse Lewis Lung Carcinoma Model. (ashpublications.org)
  • This study was designed to investigate whether heparin and its derivatives are able to inhibit tumor growth in a Lewis Lung carcinoma model. (ashpublications.org)
  • A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. (harvard.edu)
  • Lewis lung carcinoma is a tumor named after its 1951 discoverer, Dr. Margaret R. Lewis, of the Wistar Institute. (hapres.com)
  • Lewis lung carcinoma (LLC) and B 16 melanoma], to metastasize, apparently as a consequence of increased expression of a cell adhesion glycoprotein ( 8 ). (pnas.org)
  • Overall, our results demonstrated that miR-21a enriched in lung carcinoma cell-derived exosomes could promote functional expansion of MDSCs through targeting PDCD4. (nature.com)
  • In addition, white blood cell (WBC) counts and H&E-stained sections of liver, lungs, kidney, and heart were performed in order to monitor toxicity assessments. (biomedcentral.com)
  • Loss of heterozygosity on chromosome 11q23 is observed at high frequency in human nonsmall cell lung carcinomas (NSCLCs), suggesting the presence of a tumor suppressor gene. (pnas.org)
  • Human small cell lung carcinoma (SCLC) cell lines (SCLC-2 and SCLC-7) were established as described ( 14 ). (jimmunol.org)
  • With improved histopathologic procedures and the use of electron microscopy, most NSCLCs that would previously have been classified as large-cell carcinomas are identified as undifferentiated adenocarcinomas or, less frequently, as SCCs. (medscape.com)
  • To examine this hypothesis, a short‑hairpin RNA targeting versican (shVCAN) was designed and shVCAN stable‑transfected B16F1 and Lewis lung carcinoma (LLC) cell lines were established. (spandidos-publications.com)
  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. (harvard.edu)
  • Chronic obstructive pulmonary disease (COPD) is characterized by lung destruction and inflammation. (hindawi.com)
  • Pulmonary carcinoma in chromate workers. (cdc.gov)
  • In fact, a 1996 study found that the carcinoma predominantly metastasized into the lungs after tail vein injections. (wikipedia.org)
  • The experiments are performed on transplantable mouse cervical carcinomas using three drugs: photosens, alasens, and fotoditazin. (spiedigitallibrary.org)
  • Lewis-y antigen expression documented by immunohistochemistry for all patients. (knowcancer.com)
  • To study the influence of polyamine metabolism inhibitors on the growth, metastasis and ornithine decarboxylase (ODC) activity of Lewis lung carcinoma. (exp-oncology.com.ua)
  • The aim of this work was to study the effect of inhibitors of PA metabolism on the growth and metastasis of experimental Lewis lung carcinoma in mice. (exp-oncology.com.ua)
  • Inhibition of cell-adhesion protein DPYSL3 promotes metastasis of lung cancer. (beds.ac.uk)
  • Major works: Effect of staphylococcal peptidoglycan on growth and metastasis of Lewis lung carcinoma in mice // Reports of NAS of Ukraine, 2006 (in co. (org.ua)
  • Effect of Staphylococcus teichoic acid on growth and metastasis of Lewis lung carcinoma in mice. (org.ua)
  • Molluscum contagiosum pearly: Basal cell carcinoma, including partial nephrectomy for tumors of the kidney is restored. (aestheticscienceinstitute.edu)
  • Dr Migden has published numerous primary and expert review articles on basal cell carcinoma. (mdanderson.org)
  • Cemiplimab (Libtayo) demonstrated clinically meaningful antitumor activity, including durable responses, and acceptable safety in patients with metastatic basal cell carcinoma (mBCC) after progression on or intolerance to hedgehog inhibitors. (oncnursingnews.com)
  • Cemiplimab (Libtayo) demonstrated clinically meaningful antitumor activity, including durable responses, and acceptable safety in patients with metastatic basal cell carcinoma (mBCC) after progression on or intolerance to hedgehog inhibitors, according to findings from the prespecified interim analysis of the mBCC cohort of a phase 2 trial (NCT03132636) that were presented ahead of the 2020 SITC Virtual Congress. (oncnursingnews.com)
  • Pdf keynote advanced com) KEYNOTE-426 was a large phase III clinical trial that randomly assigned 861 patients with clear cell (renal cell carcinoma) RCC to either pembrolizumab + axitinib (5 mg BID) or sunitinib (50 mg daily x 4. (skigym.ru)
  • Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. (vanderbilt.edu)
  • In chapter 2, we investigate a new natural marine substrate, Dihydroaustrasulfone alcohol, from soft coral against NSCLC cell line migration and tumor growth in Lewis lung cancer (LLC)-bearing mice and its regulation mechanism. (airitilibrary.com)
  • We first discovered that dihydroaustrasulfone alcohol provided a concentration-dependent inhibitory effect on the migration and motility of human non-small cell lung carcinoma (NSCLC) A549 cells by trans-well and wound healing assays. (airitilibrary.com)
  • In their article, "Peripheral blood biomarkers correlate with outcomes in advanced non-small cell lung Cancer patients treated with anti-PD-1 antibodies," Dr. Soyano's group presents findings related to the potential predictive value of peripheral blood biomarkers in patients with NSCLC. (sitcancer.org)
  • Another novel immunotherapeutic agent is featured in the article "Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma," by Ian Lai et al. (sitcancer.org)
  • The article investigates the use of an mRNA lipid nanoparticle-based approach for the in situ delivery and production of IL-12 (IL-12-LNP) in a murine model of refractory MYC-driven hepatocellular carcinoma (HCC). (sitcancer.org)
  • Neoadjuvant Transarterial Chemoembolization Improves Survival After Liver Transplant in Patients With Hepatocellular Carcinoma. (cartorio02timoteo.com.br)
  • 2003). Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection. (geneticsmr.com)
  • 1998). In vivo, a 7-day continuous subcutaneous infusion of 31.5 mg/m2 jaspamide resulted buy AG-1024 (Tyrphostin) in a 5-day tumor growth delay in mice bearing Lewis lung carcinoma xenografts (Takeuchi et al. (themodernsolution.com)
  • The activity and durability [of the agent] seem to be promising," said Karl Lewis, MD, lead study author, and professor of medicine-medical oncology at the Colorado School of Medicine, in a virtual press briefing ahead of the 2020 SITC Virtual Congress. (oncnursingnews.com)
  • Jaspamide exhibits antitumor activity in multiple in vitro tumor models for prostate and breast carcinomas and acute myeloid leukemia (Takeuchi et al. (themodernsolution.com)
  • 1995). Jaspamide inhibits the growth of prostate carcinoma PC-3 cells by disrupting the actin cytoskeleton (Senderowicz et al. (themodernsolution.com)
  • 1995) and acts as a radiosensitizer against prostate and lung carcinoma cells in vitro (Takeuchi et al. (themodernsolution.com)
  • 2002). The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. (geneticsmr.com)
  • We concluded that dihydroaustrasulfone alcohol is a new pure compound with anti-migration and anti-tumor growth activity in lung cancer and might be applied to clinical treatment in the future. (airitilibrary.com)
  • American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. (vanderbilt.edu)
  • 2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. (vanderbilt.edu)
  • Clinical signs in parking how to buy cheap aciphex online areas and in swine and other carcinomas) and SCC of the country, requiring thousands of people who are at increased risk for severe illness should consider postponing all travel, including essential travel, to Sweden. (poysdorf.golf)
  • Regina Jacob, MD, MSCE, is an assistant professor of Clinical Medicine at The Lewis Katz School of Medicine at Temple University in North Philadelphia. (accc-cancer.org)
  • Lynch TJ, Bell DW, Sordella R, et al Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (nchu.edu.tw)
  • Effects of Tussilago farfara polysaccharides on the expression of PD-1 (CD279) and PD-L1 (CD274) in peripheral blood and tumor tissue lymphocytes in with Lewis lung carcinoma. (greenmedinfo.com)
  • Lewis jj, leung dh, brennan mf: Of genitourinary sarcoma, the overall mortality is higher than bronchoscopy, with pneumotho- long-term stability (doubling time less than two-thirds the strongest predictor of by echocardiography or cardiac tp23). (aestheticscienceinstitute.edu)
  • Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. (vanderbilt.edu)
  • The same study found that selenium was critical in the reduction of toxicity related to radiation treatment of lung cancer. (winecountrycrossfit.com)
  • Lung cancer risk and radiation dose among women treated for breast cancer [see comments]. (familialcancerdatabase.nl)
  • Lung carcinoma after radiation therapy in women treated with lumpectomy or mastectomy for primary breast carcinoma. (familialcancerdatabase.nl)
  • Furthermore, dihydroaustrasulfone alcohol markedly inhibited tumor growth in Lewis lung cancer (LLC)-bearing mice. (airitilibrary.com)
  • EGFR Fusions as Novel Therapeutic Targets in Lung Cancer. (vanderbilt.edu)
  • Lai MD, Yen MC, Lin CM, Tu CF, Wang CC, Lin PS, Yang HJ, Lin CC. The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal model. (nchu.edu.tw)
  • Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. (nchu.edu.tw)
  • Advantages are avoidance of 360 units of bleomycin: a cumulative dose that is associated with a small but real incidence of bleomycin lung toxicity. (covidayacancer.org)
  • They found that various forms of THC showcased anti-tumor potential for certain afflictions, particularly in the case of Lewis lung carcinoma and leukemia. (thecannidote.com)
  • 3] observed significantly elevated risks for 9 cancer sites in women diagnosed with breast cancer before age 50: esophagus, stomach, lung, bone, connective tissue, breast, corpus uteri, ovary and myeloid leukemia, whereas only corpus uteri and myeloid leukemia were increased in women diagnosed after age 49. (familialcancerdatabase.nl)
  • Kinetics, histological and biochemical characteristics of transplantable cholangiocellular RS-1 carcinoma were studied after intrahepatic and subcutaneous grafting to outbred rats. (exp-oncology.com.ua)
  • Pembrolizumab prolongs overall survival and has a favourable benefit-to-risk profile in patients with previously treated, PD-L1-positive, advanced non-small-cell lung pdf keynote advanced cancer. (skigym.ru)
  • Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib. (vanderbilt.edu)
  • Long-Term Outcomes of a Phase I Study With UV1, a Second Generation Telomerase Based Vaccine, in Patients With Advanced Non-Small Cell Lung Cancer. (cocites.com)
  • 3). Scind Laboratories, University of San Francisco, 400 rats bearing Walker 256 carcinoma (200 treated with Amygdalin, 200 controls), with 80% increase in life span at optimum dosage (500 mg Amgdalin/kg body weight). (b17.com.au)
  • Liu CY, Seen S. Gefitinib therapy for advanced non-small-cell lung cancer. (nchu.edu.tw)
  • A second carcinoma often develops close to the primary lesion ! (amboss.com)
  • The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas. (geneticsmr.com)
  • 2001). Frequent epigenetic inactivation of RASSF1A in human bladder carcinoma. (geneticsmr.com)
  • The same chemicals and immune response that produce psoriasis in the skin circulate in the blood and can trigger inflammation in the joints, says Matt Lewis, MD, MPH, a dermatologist at Stanford Health Care in Palo Alto, California. (managedhealthcareexecutive.com)
  • Chronic inflammation in the blood is thought to play a key role, Lewis says. (managedhealthcareexecutive.com)
  • Dustin Diamond died on February 1 at age 44 after a battle with stage IV small cell carcinoma. (keri-russell.info)
  • In 1959, Ruby went to Cuba ostensibly to visit a friend, influential Dallas gambler Lewis McWillie, an associate of Mafia boss Santo Trafficante. (likefm.org)
  • One group of researchers found that selenium was effective in preventing lung cancer among people with lower levels of the trace element ( 16 ). (winecountrycrossfit.com)
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  • It may be used diagnostically in order to determine if a medical condition is present or not (such as finding a lung cancer), interventionally as a procedure (such as removing a blood clot in an artery), or as a treatment. (cartorio02timoteo.com.br)
  • The risk may partially be due to some psoriasis therapies, which block an immune system chemical called TNF, Lewis says. (managedhealthcareexecutive.com)
  • 2002). Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. (geneticsmr.com)
  • Psychosocial factors, including isolation and depression, only partially explain how psoriasis may lead to obesity, Lewis says. (managedhealthcareexecutive.com)