A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Tumors or cancer of the LUNG.
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A malignant epithelial tumor with a glandular organization.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A cell line derived from cultured tumor cells.
Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN. It is characterized by solitary nodules or ulcerated tumors.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tumors or cancer of the SKIN.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Clinically benign, histologically malignant, recurrent cutaneous T-cell lymphoproliferative disorder characterized by an infiltration of large atypical cells surrounded by inflammatory cells. The atypical cells resemble REED-STERNBERG CELLS of HODGKIN DISEASE or the malignant cells of CUTANEOUS T-CELL LYMPHOMA. In some cases, lymphomatoid papulosis progresses to lymphomatous conditions including MYCOSIS FUNGOIDES; HODGKIN DISEASE; CUTANEOUS T-CELL LYMPHOMA; or ANAPLASTIC LARGE-CELL LYMPHOMA.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the NASOPHARYNX.
DNA present in neoplastic tissue.
Tumors or cancer of the THYROID GLAND.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the human BREAST.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
A general term for various neoplastic diseases of the lymphoid tissue.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Tumors or cancer of the BRONCHI.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Tumors or cancer of the STOMACH.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
Antibodies produced by a single clone of cells.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Tumors or cancer of the URINARY BLADDER.
Neoplasms composed of more than one type of neoplastic tissue.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
RNA present in neoplastic tissue.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Tumors or cancer of the UTERINE CERVIX.
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Loss of structural differentiation and useful function of neoplastic cells.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Elements of limited time intervals, contributing to particular results or situations.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Transplantation between animals of different species.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Tumors or cancer of the gallbladder.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A DNA-binding protein that represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Established cell cultures that have the potential to propagate indefinitely.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Tumors or cancer of the SALIVARY GLANDS.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Tumors or cancer of the NOSE.
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Biochemical identification of mutational changes in a nucleotide sequence.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The quantity of volume or surface area of CELLS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Mapping of the KARYOTYPE of a cell.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
The degree of replication of the chromosome set in the karyotype.
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An expression of the number of mitoses found in a stated number of cells.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
An antineoplastic agent derived from BLEOMYCIN.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.

Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. (1/382)

The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in various tumor cell lines including human non-small cell lung carcinoma (NSCLC) cells, which are resistant to the natural all-trans retinoic acid and to many synthetic receptor-selective retinoids. Although the mechanism of this effect was not elucidated, it was found to be independent of nuclear retinoid receptors. In the present study, we analysed the mechanisms by which CD437 induces apoptosis in two human NSCLC cell lines: H460 with wild-type p53 and H1792 with mutant p53. Both cell lines underwent apoptosis after exposure to CD437, although the cell line with wild-type p53 (H460) was more sensitive to the induction of apoptosis. CD437 increased the activity of caspase in both cell lines, however, the effect was much more pronounced in the H460 cells. The caspase inhibitors (Z-DEVD-FMK and Z-VAD-FMK) suppressed CD437-induced CPP32-like caspase activation and apoptosis in both cell lines. CD437 induced the expression of the p53 gene and its target genes, p21, Bax, and Killer/DR5, only in the H460 cells. These results suggest that CD437-induced apoptosis is more extensive in NSCLC cells that express wild-type p53, possibly due to the involvement of the p53 regulated genes Killer/DR5, and Bax although CD437 can also induce apoptosis by means of a p53-independent mechanism. Both pathways of CD437-induced apoptosis appear to involve activation of CPP32-like caspase.  (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (2/382)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important.  (+info)

Lung cancer incidence rates by histologic type in high- and low-risk areas; a population-based study in Osaka, Okinawa, and Saku Nagano, Japan. (3/382)

We investigated lung cancer incidence by histologic type using the data from population-based cancer registries in high-risk (Osaka and Okinawa) and low-risk (Saku Nagano) areas. Since the proportion of cases with histologic types identified was not sufficiently high, sex- and age-specific incidence rates by histologic type were estimated assuming that the distribution of histologic types was the same across the same sex and age groups regardless of reporting status. Compared to Saku in Nagano Prefecture, the cumulative risk of lung cancer incidence rates in Osaka and Okinawa were 1.3 and 1.5 times higher for males and 1.3 and 1.2 times higher for females, respectively. When divided by histologic type, male adenocarcinoma and small cell carcinoma were 1.6-2.1 times higher in Osaka and Okinawa, while squamous cell carcinoma was 1.6 times higher only in Okinawa compared to Saku Nagano. In females, squamous cell carcinoma and small cell carcinoma were 2.5-3.3 times higher in Osaka and Okinawa compared to Saku Nagano, while adenocarcinoma was almost equal in the 3 areas. These results indicate that the pattern of incidence of lung cancer by histologic type may differ between high- and low- risk areas.  (+info)

Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. (4/382)

Poly(ADP-ribose) polymerase (PADPRP) is a nuclear DNA-binding enzyme that can modulate chromatin structure close to DNA replication, recombination and repair regions. Two-allele polymorphism on the PADPRP chromosome 13 pseudogene has been studied in several ethnic subpopulations, and the association of each allele with different types of cancer has been investigated. To study the frequency of the allele in the context of lung cancer, we performed a PCR assay for the PADPRP polymorphism in 288 lung cancer patients and 292 matched controls and examined the frequency of the alleles in different ethnic groups. Our results showed that the allele distribution was significantly different among members of different ethnic groups. Specifically, the A allele was dominant in Mexican-American and Caucasian groups but not in the African-American group. The frequencies of the B allele in Mexican-American, Caucasian and African-American controls were 0.184, 0.218 and 0.606, respectively, with the Caucasian cases and controls showing an almost identical lower B allele frequency (0.199 in cases versus 0.218 in controls), and the African-American cases and controls showing an almost identical but considerably higher frequency (0.578 in cases versus 0. 606 in controls). In contrast, the Mexican-American cases and controls exhibited a considerable difference in the B allele frequency (0.306 in cases versus 0.184 in controls). When we combined subjects with the AB or BB genotype into a susceptible genotype group and compared them with the AA group using univariate analysis, the susceptible genotype was not shown to be associated with a risk of lung cancer in either the Caucasian or African-American subpopulation but was significantly associated with an increased risk (2.29-fold) of lung cancer in the Mexican-American group. When lung cancer was categorized by histologic type, no elevated risk was noted for squamous cell carcinoma in any ethnicity. However, in Mexican-Americans, susceptible genotypes were associated with significantly increased risks of adenocarcinoma (3. 21-fold) and large cell carcinoma (10.79). Our study and others have demonstrated that the PADPRP polymorphism may modify an individual's susceptibility to certain cancers. Assessment of the interaction between genetic constitution and environmental exposure might expand our understanding of carcinogenesis and enhance our ability to evaluate the populational cancer risk.  (+info)

p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer. (5/382)

The oncogene product epidermal growth factor receptor (EGF-R), the tumour suppressor gene product p53 and anti-p53 antibodies are detectable in the serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure and after exposure to polycyclic aromatic hydrocarbons or vinylchloride. In the first step, this study investigated the possible diagnostic value of serum EGF-R, p53-protein and anti-p53 antibodies, measured by an enzyme-linked immunosorbent assay, in lung tumour patients. In addition to being investigated on a molecular epidemiological basis, these parameters were examined as biomarkers of carcinogenesis, especially with regard to asbestos incorporation effects or of radon-induced lung cancers. Also, a possible effect of cigarette smoking and age dependence were studied. A total of 116 male patients with lung or pleural tumours were examined. The histological classification was four small-cell cancers, six large-cell cancers, 32 adenocarcinomas, 47 squamous carcinomas, 12 mixed lung carcinomas, five diffuse malignant mesotheliomas and ten lung metastasis of extrapulmonary tumours. Twenty-two lung cancers and all mesotheliomas were related to asbestos, 22 lung cancers were related to ionizing radiation and 61 patients had cigarette smoke-related lung cancer. Besides these patients 50 male patients with non-malignant lung or pleural diseases were included; of the latter eight subjects suffered from asbestosis. Controls were 129 male subjects without any lung disease. No significantly elevated or decreased serum values for p53 protein, EGF-R, or anti-p53 antibodies as a function of histological tumour type, age, or degree and type of exposure (asbestos, smoking, ionizing radiation) could be found. The utility of p53-protein, EGF-R and anti-p53 antibodies as routine biomarkers for screening occupationally derived lung cancers is limited.  (+info)

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53. (6/382)

Recent investigations have revealed that mutations of the loop-sheet-helix motif of p53 is a significant factor for a poor prognosis in patients with non-small-cell lung cancer (NSCLC). To clarify this mechanism, bcl-2 and bax expression were evaluated in relation to mutations of p53. Tumor tissues of 203 patients with NSCLC were analyzed. Immunohistochemistry was performed to evaluate bcl-2 and bax expression, and polymerase chain reaction single-strand conformation polymorphism following direct sequencing was performed to investigate p53 status. A total of 79 carcinomas were bcl-2 positive, 146 carcinomas were bax positive, and 72 carcinomas had missense mutations of p53. There was no difference in bcl-2 expression in relation to p53 status. On the other hand, tumors with structural mutations of p53 had significantly lower expression of bax than those with wild-type p53 (P = 0.0026). In contrast, tumors with mutations of the loop-sheet-helix motif of p53 had significantly higher expression of bax than those with wild-type p53 (P = 0.0236). The frequency of a bcl-2/bax ratio of >/=1 was significantly lower in tumors with mutations of the loop-sheet-helix motif than that in tumors with wild-type p53 (P = 0.0240). The bcl-2/bax ratio status was a significant factor for a prognosis in patients with NSCLC (P = 0.0083). Mutations of the loop-sheet-helix motif of p53 were correlated with overexpression of bax, while other mutations of p53 were correlated with low levels of bax expression. This variation in pattern of bax expression in relation to mutant p53 might reflect the biological behavior of tumors in patients with bcl-2-positive NSCLC.  (+info)

k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. (7/382)

Environmental carcinogen exposure is requisite for the development of nearly all lung cancer, and it is well known that asbestos exposure interacts synergistically with tobacco smoke to induce lung cancer. However, the precise molecular lesions induced by asbestos are unknown. Furthermore, it is also unknown whether asbestos carcinogenesis proceeds in a fashion independent of or dependent upon the induction of fibrosis in workers with high asbestos exposures. Previous studies have suggested that asbestos is associated with the presence of a k-ras mutation in adenocarcinoma of the lung. We aimed to test whether occupational asbestos exposure was associated with k-ras codon 12 mutations in lung adenocarcinoma tumors and to determine whether this was conditional on the presence of asbestosis. All newly diagnosed, resectable lung cancer patients receiving treatment at the Massachusetts General Hospital between November 1992 and December 1996 were eligible to participate. Because k-ras mutation is very strongly associated with adenocarcinoma, and men were more likely to be occupationally exposed to asbestos, the study was restricted to males with this histological diagnosis. There were 84 male patients with available questionnaire-derived work history data and paraffin-embedded tumor tissue for determination of k-ras mutation status. Chest radiographic evaluation was done for all of the patients who reported occupational exposure to asbestos. The prevalence of k-ras mutation was higher among those with a history of occupational asbestos exposure (crude odds ratio, 4.8; 95% confidence interval, 1.5-15.4) compared to those without asbestos exposure, and this association remained after adjustment for age and pack-years smoked (adjusted odds ratio, 6.9; 95% confidence interval, 1.7-28.6). An index score that weights both the dates of exposure and the estimated intensity of exposure indicated that those with k-ras mutations had significantly greater asbestos exposures than those without mutations (P < 0.01). Analysis of the descriptive components of exposure indicated that the duration of exposure was not associated with k-ras mutation, but that the time since initial exposure was significantly associated with mutation status. The association of k-ras mutation and reported asbestos exposure was not dependent on the presence of radiographic evidence of asbestos-related disease. These data suggest that asbestos exposure increases the likelihood of mutation at k-ras codon 12 and that this process occurs independently of the induction of interstitial fibrosis.  (+info)

Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. (8/382)

BACKGROUND: Several molecular changes, including loss of heterozygosity (i.e., deletion of one copy of allelic DNA sequences) and alterations in microsatellite DNA, have been detected early in the pathogenesis of lung cancer, even in histologically normal epithelium. In the bronchial epithelium of patients with lung cancer, we have determined the frequency, size, and patterns of molecularly abnormal clonal patches. METHODS: We studied formalin-fixed, paraffin-embedded samples from 16 surgically resected lung carcinomas (five squamous cell carcinomas, four small-cell carcinomas, six adenocarcinomas, and one large-cell carcinoma). From each carcinoma, we microdissected foci (each containing about 200 cells) of tumor tissue and equivalent samples of histologically normal and abnormal epithelium. Furthermore, multiple discontinuous foci of bronchial epithelium were analyzed from methanol-fixed samples from three additional patients with lung cancer (two with squamous cell carcinoma and one with adenocarcinoma). We used two-step polymerase chain reaction-based assays involving 12 microsatellite markers at seven chromosomal regions frequently deleted in lung cancer. RESULTS: Two hundred eighteen foci of nonmalignant bronchial epithelium (195 of histologically normal or slightly abnormal epithelium and 23 of dysplastic epithelium) were studied from the 19 surgically resected lobectomy specimens. Thirteen (68%) of the 19 specimens had at least one focus of bronchial epithelium with molecular changes. At least one molecular abnormality was detected in 32% of the 195 histologically normal or slightly abnormal foci and in 52% of the 23 dysplastic foci. Extrapolating from our two-dimensional analyses, we estimate that most clonal patches contain approximately 90 000 cells. Although, in a given individual, tumors appeared homogeneous with respect to molecular changes, the clonally altered patches of mildly abnormal epithelium were heterogeneous. CONCLUSIONS: Our findings indicate that multiple small clonal or subclonal patches containing molecular abnormalities are present in normal or slightly abnormal bronchial epithelium of patients with lung cancer.  (+info)

Large cell carcinoma is a type of lung cancer. The term large cell refers to the appearance of the cancer cells when viewed under a microscope. The tumors associated with this type of cancer are also typically large.
Large cell carcinoma Accounts for 5-10% of all lung cancers. Strongly associated with cigarette smoking. The lesion occurs peripherally and grows rapidly, with early metastases and a poor outcome They lack any diagnosic features to suggest their diagnosis prior to biopsy.
Some of these tumours showed a solid growth pattern of polygonal cells with eosinophilic intracytoplasmic inclusion bodies. Histochemically, these cells were periodic acid-Schiff-negative. Immunohistochemically, vimentin and neuron-specific enolase were positive. Epithelial membrane antigen was focally and weakly positive and p53 was positive in 60% of tumoral cells.. Electron microscopy revealed intracytoplasmic inclusion bodies consisting of whorled intermediate filaments. Based on histological and immunohistochemical findings, the patient was diagnosed as having pulmonary large cell carcinoma with rhabdoid phenotype. Because of its aggressive clinical course, early diagnosis and decision on therapy is very important for this disease.. ...
Background: The magnitude of the link between cigarette smoking and lung cancer may vary by histological type.. Methods: We used polytomous logistic regression to evaluate whether aspects of smoking have different effects across four histological types in the Nurses Health Study.. Results: From 1976 to 2002, we identified 1062 cases of lung cancer: squamous cell (n 201), small cell (n 236), adenocarcinoma (n 543) and large cell carcinoma (n 82), among 65 560 current or former smokers. Risk reduction after quitting ranged from an 8 reduction (relative risk (RR): 0.92, 95 CI 0.91 to 0.94) to a 17 reduction (RR: 0.83, 95 CI 0.80 to 0.86) per year for adenocarcinoma and small cell carcinoma, respectively, with a 9 reduction observed for large cell carcinoma and an 11 reduction observed for squamous cell carcinoma. The association of age at smoking initiation and former cigarette smoking was similar across types, while the association of smoking duration differed. The risk of adenocarcinoma ...
article{cf0dde2a-1de1-4aeb-9f7b-5f410161f5f1, abstract = {Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical specimens. Our study implies that the cytokeratins we used work better with surgical material, but are generally comparable to monospecific cytokeratin antibodies. Also, EMA is a reliable marker for epithelial ...
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Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269,PubMed:15118125, ECO:0000269,PubMed:16533793, ECO:0000269,PubMed:16672372}. Note=The gene represented in this entry is involved in disease pathogenesis ...
Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269,PubMed:15118125, ECO:0000269,PubMed:16533793, ECO:0000269,PubMed:16672372}. Note=The gene represented in this entry is involved in disease pathogenesis ...
The heterogeneity of the H460 large cell lung cancer cell line was investigated by selecting for chemokinetic cells from a CON population that demonstrated both chemokinesis and chemotaxis. Using Boyden chambers, cells that migrated under chemokinetic conditions were collected and their numbers expanded. Time-lapsed microscopy under isotropic conditions showed that KINE cells moved faster and changed directions more frequently than CON confirming their chemokinetic character. KINE cells which lacked stable focal adhesion were also less adhesive to culture plates compared to CON cells which had focal adhesions at the leading edge shown by phospho-Paxillin-tyr118 antibody labeling. Weak substrate adhesion in KINE cells may account for motile characteristics of rapid and random movement [16-19]. Furthermore, the selection for increased chemokinesis did not compromise the ability of KINE cells to chemotax. KINE cells were also significantly more invasive compared to CON.. These results underscore ...
Principal Inclusion Criteria: - Female or male patients age , 18 years-old - ECOG performance Status 0 or 1 at study entry - Life expectancy of at least 3 months - Histologically confirmed non-squamous NSCLC (adenocarcinoma, large cell carcinoma, undifferentiated carcinoma or other) - Stage IIIB-IV cancer or delayed relapse of any stage not amenable to surgery or radiotherapy with curative intent. - PD-L1 expression by immunohistochemistry in , 50% of tumor cells - Patients must be chemotherapy-naïve for the advanced stage of the disease. Previous neoadjuvant and/or adjuvant chemotherapy is allowed for patients who successfully underwent complete radical surgery and if last treatment was administered more than 12 months prior to the start of the study treatment. - At least one measurable lesion by CT scan based on RECIST 1.1 performed within 28 days prior to start of study treatment - Adequate hematological, hepatic, and renal functions - Women of childbearing potential (WOCBP) must have a ...
Cellular glutathione (GSH) levels were measured from 27 human lung tumor biopsies, enzymatically disaggregated, and compared with cells isolated from normal lung of the same patients. GSH levels from normal lung were similar among patients with a mean value of 11.20 ± 0.58 (SEM) nmol GSH/mg protein (24 patients) with a range from 6.1 to 17.5 nmol GSH/mg protein. GSH levels varied considerably within and across histological tumor types with the following values: adenocarcinomas, 8.83 ± 0.96 nmol/mg protein (8 patients); large cell carcinomas, 8.25 ± 2.51 nmol/mg protein (3 patients); and squamous cell carcinomas, 23.25 ± 5.99 nmol/mg protein (8 patients). The cyclic GSH reductase assay gave only average GSH values and could not distinguish possible GSH variation among subpopulations of cells isolated. Cell volume measurements and microscopic evaluation of cells isolated from both tumors and normal lung revealed heterogeneity with respect to cell types present. To determine the extent of thiol ...
Large cell neuroendocrine carcinoma in the salivary glands is rare. We report a second case of large cell neuroendocrine carcinoma of the submandibular gland diagnosed at autopsy, and a review of the literature. A 68-year-old Japanese man was referred to our hospital for thorough investigation of swelling on the right side of his neck. Fine-needle aspiration cytology of the cervical mass suggested poorly differentiated metastatic carcinoma. The primary tumor could not be detected by several examinations. One month after admission, he died of cancer. An autopsy was performed, and it revealed a tumor of the right submandibular gland. The histopathological diagnosis was large cell neuroendocrine carcinoma of the submandibular gland. To the best of our knowledge, only eight cases of large cell neuroendocrine carcinoma in the salivary glands, including our case, have been reported. This report indicates total biopsy and immunohistochemistry are necessary for diagnosing large cell neuroendocrine carcinoma
Patients who underwent chemotherapy had longer overall survival. Research presented in the July 2012 issue of the International Association for the Study of Lung Cancers (IASLC) Journal of Thoracic Oncology, concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were treated with perioperative chemotherapy and surgery had better overall survival outcomes than patients treated with surgery alone.. Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. Of those, about 30 percent of patients have limited disease SCLC. Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to SCLC. Surgery in these groups of patients are rare and researchers wanted to know if perioperative chemotherapy would benefit the patients.. The retrospective study looked at 74 patients who underwent lung cancer surgery at the Surgical Centre Marie Lannelongue in Le ...
Two mutually exclusive genomic LCNEC subtypes have been identified by molecular studies: one shows co-mutated TP53 and RB1, which is similar to SCLC, and the STK11/KEAP1 subtype with predominantly RB1 wild-type that is similar to NSCLC.. Reviewing clinical data and tumour specimens of 232 patients in the Netherlands Cancer Registry and Pathology Registry from 2003 to 2012, this retrospective analysis identified 148 patients who had been diagnosed with LCNEC. Of these, samples from all patients receiving first-line chemotherapy for panel-consensus diagnosed LCNEC were included for next-generation sequencing (NGS) for the TP53, RB1, STK11, and KEAP1 genes. RB1 (pRB1, 13A10) was analysed by immunohistochemistry, with samples having an H-score of ≥50 considered positive.. The results of the NGS and pRB1 were correlated with overall survival (OS) and progression-free survival (PFS) by Kaplan Meier plots and Log-rank test.. Quality control of the samples determined that 79 samples were sufficient ...
Disease Ontology : 12 A cervix carcinoma that has material basis in neuroendocrine tissue and is characerized by a diffuse, organoid, trabecular, or cord-like pattern of neoplastic cells with abundant cytoplasm, large nuclei, prominent nucleoli, and a high mitotic rate ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
M-800:M-800) Neoplasms, NOS M-8000/0 Neoplasm, benign M-8000/1 Neoplasm, uncertain whether benign or malignant M-8000/3 Neoplasm, malignant M-8000/6 Neoplasm, metastatic M-8000/9 Neoplasm, malignant, uncertain whether primary or metastatic M-8001/0 Tumour cells, benign M-8001/1 Tumour cells, uncertain whether benign or malignant M-8001/3 Tumour cells, malignant M-8002/3 Malignant tumour, small cell type M-8003/3 Malignant tumour, giant cell type M-8004/3 Malignant tumour, spindle cell type M-8005/0 Clear cell tumour, NOS M-8005/3 Malignant tumour, clear cell type (M-801:M-804) Epithelial neoplasms, NOS M-8010/0 Epithelial tumour, benign M-8010/2 Carcinoma in situ, NOS M-8010/3 Carcinoma, NOS M-8010/6 Carcinoma, metastatic, NOS M-8010/9 Carcinomatosis M-8011/0 Epithelioma, benign M-8011/3 Epithelioma, malignant M-8012/3 Large cell carcinoma, NOS M-8013/3 Large cell neuroendocrine carcinoma M-8014/3 Large cell carcinoma with rhabdoid phenotype M-8015/3 Glassy cell carcinoma M-8020/3 Carcinoma, ...
The characteristics of 112 patients with COPD were as follows; mild COPD/moderate COPD: number of patients (male) 42 (21)/70 (57), age 71.0/70.5 years-old, pathological stage of NSCLC IA 30/25 IB 5/8 IIA 3/8 IIB 3/4 IIIA 5/19 IIIB 0/1, histology adenocarcinoma (Ad) 29/40 squamous cell carcinoma (Sq) 9/27 large cell neuroendocrine carcinoma (LCNEC) 2/2 pleomorphic carcinoma 0/2 Ad + Sq 1/0 Sq + LCNEC 1/0. Each of OS and DFS was 2287 days (1984 - 2589) and 2015 (1679 - 2351) days in mild COPD patients and 2004 (1873 - 2135) days and 1768 (1656 -1890) days in moderate COPD patients. Compared with patients with mild COPD, patients with moderate COPD had increased risk of worse OS (p = 0.035) but had no differences in CSS (p = 0.867) and DFS (p = 0.125) by log-rank analysis. ...
Small cell carcinoma of the lung (SCLC) together with the large cell neuroendocrine carcinoma (LCNEC), typical carcinoid (TC), and atypical carcinoid (AC) make a group of morphologically identifiable neuroendocrine tumors. The...
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA. Mod Pathol. 2018 PMID: 30140036. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla ...
Introduction: Lung neuroendocrine tumors (NET) are rare and heterogeneous, with wide range of aggressiveness. Aim: Describe clinical and epidemiologic characteristics, stage, treatment and survival of patients with lung NET according to histological group -[typical carcinoid (TC), atypical carcinoid (AT), large cell neuroendocrine carcinoma (NEC). Methods: Retrospective longitudinal, multicenter study analyzing files of patients diagnosed with NET from 2005 to 2010. Small cell carcinoma was excluded. Comparisons among groups were done with X2. Survival curves were generated using Kaplan-Meier method. Results: 137 patients were included, mean age (SD) 59 (± 14) years; 71 (52%) male; 82 (60%) non-smokers. Histological classification: 54 TC, 49 NEC and 34 AC. Table below describes patients characteristics. Follow-up ranged from 1 to 78 months. Twenty seven patients (20%) died, 1 in TC, 2 in AC, 23 in NEC. The median overall survival (OS) calculated for NEC was 42 months, for other patients median ...
Using enrichment analysis for Gene Ontology Biological Function we see that the genes/proteins with up-regulated PTMs and expression levels are associated with RNA processing, RNA splicing and, gene expression. Re-running the analysis for the sub-cluster of very highly regulated PTMS/genes (the large cluster in the middle) reveals enrichment for neuronal functions including: neuron projection, axon guidance, and neuron morphology. Enrichment for genes that are up-regulated in disease (using the Disease Perturbations from GEO Up library) shows enrichment for neuronal related cancers including: oligodendroglioma, multiple sclerosis, astrocytoma, and large cell neuroendocrine carcinoma. Finally, enrichment using the MGI Mammalian Phenotype library shows enrichment for genes that cause neuronal abnormalities in mice after knockdown including: abnormal neuron morphology, abnormal brain morphology, abnormal spinal cord morphology, and abnormal nervous system. Collectively, these results indicate that ...
Source:http://linkedlifedata.com/resource/umls/id/C1265997 NCI: A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells. ...
release of git://git.kernel.org/pub/scm/linux/kernel/git/lenb/linux-acpi-2.6: gcc-4.6: ACPI: fix unused but set variables in ACPI ACPI thermal: make procfs I/F depend on CONFIG_ACPI_PROCFS ACPI video: make procfs I/F depend on CONFIG_ACPI_PROCFS ACPI processor: remove deprecated ACPI procfs I/F ACPI power_resource: remove unused procfs I/F ACPI: remove deprecated ACPI procfs I/F ACPI: introduce drivers/acpi/sysfs.c ACPI: introduce module parameter acpi.aml_debug_output ACPI: introduce drivers/acpi/debugfs.c ACPI, APEI, ERST debug support ACPI, APEI, Manage GHES as platform devices ACPI, APEI, Rename CPER and GHES severity constants ACPI, APEI, Fix a typo of error path of apei_resources_request ACPI / ACPICA: Fix reference counting problems with GPE handlers ACPI: Add the check of ADR flag in course of finding ACPI handle for PCI device ACPI / Sleep: Drop acpi_suspend_finish() ACPI / Sleep: Consolidate suspend and hibernation routines ACPI / Wakeup: Simplify enabling of wakeup devices ACPI / ...
The objectives of this research were to test treatment and survival differences between women and men with lung cancer as there is minimal investigation in the literature. Three research questions were developed with statistical testing for gender differences based on similar cancer type, stage, treatment assignment and survival. Data for 44,863 primary lung cancer cases were collected from eight U.S. state-based cancer registries to investigate the research questions. The lung cancer incidence data included the morphological cell-types of adenocarcinoma (AC); squamous cell carcinoma (SCC); large cell carcinoma (LCC) and small cell carcinoma (SCC). Stage, grade, treatment type, as well as, individual characteristics such as gender, age at diagnosis, marital status at diagnosis and race were other variables obtained to be included in the statistical models. Reporting the overall effect for lung cancer gender specific treatment differences or survival has not been demonstrated in the literature to the
Small Cell Cancer (SCLC) is much more rare than Non-Small Cell, only about 15% of cases are Small Cell. Within SCLC, there are three different types: small cell carcinoma (oat cell cancer), mixed small cell/large cell carcinoma and combined small cell carcinoma. Most SCLC cases are oat cell. SCLC is the most aggressive form of lung cancer compared to the other type. It is mainly caused by smoking and starts in the bronchi (breathing tubes) in the center of the chest. This type of lung cancer grows quickly and produces large tumors. Because SCLC grows so quickly, it also metastasizes rapidly to other parts of the body including the brain, liver and bone. Metastasis is when a part of a cancerous tumor breaks off from the original tumor and spreads to another part of the body, spreading the cancer. When you have SCLC, there are many symptoms that come from it, including bloody sputum (spitting up blood), chest pain, coughing, loss of appetite, shortness of breath, weight loss, wheezing, facial ...
Small Cell Cancer (SCLC) is much more rare than Non-Small Cell, only about 15% of cases are Small Cell. Within SCLC, there are three different types: small cell carcinoma (oat cell cancer), mixed small cell/large cell carcinoma and combined small cell carcinoma. Most SCLC cases are oat cell. SCLC is the most aggressive form of lung cancer compared to the other type. It is mainly caused by smoking and starts in the bronchi (breathing tubes) in the center of the chest. This type of lung cancer grows quickly and produces large tumors. Because SCLC grows so quickly, it also metastasizes rapidly to other parts of the body including the brain, liver and bone. Metastasis is when a part of a cancerous tumor breaks off from the original tumor and spreads to another part of the body, spreading the cancer. When you have SCLC, there are many symptoms that come from it, including bloody sputum (spitting up blood), chest pain, coughing, loss of appetite, shortness of breath, weight loss, wheezing, facial ...
Histologically confirmed Non-Small Cell Lung Cancer (NSCLC) of adenocarcinoma, squamous cell carcinoma, large cell carcinoma, or NSCLC not otherwise specified. Patients with suspected NSCLC may enroll prior to the diagnostic biopsy in order to obtain both the diagnostic and molecular analysis-required specimen during the same procedure. Must have blood work within 30 days prior to biopsy to eliminate any unnecessary biopsies on patients that do not qualify (screen failures) due to laboratory values that do not meet the inclusion/exclusion criteria. If a patient has blood work obtained at an outside facility, this can be utilized for the preliminary assessment prior to biopsy, but final inclusion/exclusion values must be obtained within 14 days of start of treatment ...
Results RHAMM expression in the subgroup of large cell carcinomas (LCC) was associated with inferior survival (p=0.000223). Median overall survival was 92 versus 18 months for RHAMM-negative and positive patients, respectively. This survival difference remained significant in both nodal negative and positive patients (pN0: p=0.013 and pN≥1: p=0.007, respectively). P-gp expression was associated with inferior survival in adenocarcinomas (ACA; p=0.013) and appeared to be a postsurgical Union International Contre le Cancer (pUICC)- stage and gender-independent prognostic factor, irrespective of adjuvant chemotherapy, in the multivariable analysis; considering nodal status, this survival difference applied to pN0 cancers (p=0.026).. ...
Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha ...
ACPI: Video: Increase buffer size for writes to brightness proc file. In order to be able to write the value 100 to /proc/acpi/video/.../brightness, we have to allocate 5 bytes: 4 characters will be written (1, 0, 0 plus null byte), and 1 byte should be buffer for a terminating NULL character. http://bugzilla.kernel.org/show_bug.cgi?id=9278 Signed-off-by: Danny Baumann ,[EMAIL PROTECTED], Acked-by: Zhang Rui ,[EMAIL PROTECTED], Signed-off-by: Len Brown ,[EMAIL PROTECTED], --- drivers/acpi/video.c , 2 +- 1 files changed, 1 insertions(+), 1 deletions(-) diff --git a/drivers/acpi/video.c b/drivers/acpi/video.c index dce0a6e..44a0d9b 100644 --- a/drivers/acpi/video.c +++ b/drivers/acpi/video.c @@ -897,7 +897,7 @@ acpi_video_device_write_brightness(struct file *file, { struct seq_file *m = file-,private_data; struct acpi_video_device *dev = m-,private; - char str[4] = { 0 }; + char str[5] = { 0 }; unsigned int level = 0; int i; - To unsubscribe from this list: send the line unsubscribe ...
The value 805262864 varies, and is the physical address, in decimal, of one of the ACPI tables. The error message is displayed when a 1024 dword page table array used by setupldr runs out of space. This table is used for mapping various physical addresses, such as those of ACPI tables (a separate table identity maps the lower 16MB used by setupldr code and data). Setupldr only looks at ACPI tables (FACP) to determine make and model of the system. The make and model of the system is needed when setupldr scans the good/bad bios lists contained in txtsetup.sif. The good/bad bios lists are used to bypass installation of the ACPI enabled kernel on certain systems known to have ACPI problems. The code loop that scans the lists creates a new mapping each time it reads an ACPI table, and never frees mappings. The code uses FACP OEM ID to determine the system model. The code sequentially reads tables listed in the RSDT array until the FACP is found. Each read consumes one page table entry. If more that 4 ...
This patch adds acpi_bus_get_parent(), which ascends the namespace until it finds a parent with an acpi_device. Then we use acpi_bus_get_parent() in acpi_add_single_object(), so callers dont have to figure out or...
We are going to change ARM virt ACPI DSDT table, which will cause make check to fail, so temporarily add related golden masters to ignore list. Signed-off-by: Heyi Guo ,[email protected], Reviewed-by: Michael S. Tsirkin ,[email protected], --- Cc: Peter Maydell ,[email protected], Cc: Michael S. Tsirkin ,[email protected], Cc: Igor Mammedov ,[email protected], Cc: Shannon Zhao ,[email protected], Cc: [email protected] Cc: [email protected] --- tests/qtest/bios-tables-test-allowed-diff.h , 3 +++ 1 file changed, 3 insertions(+) diff --git a/tests/qtest/bios-tables-test-allowed-diff.h b/tests/qtest/bios-tables-test-allowed-diff.h index dfb8523c8b..32a401ae35 100644 --- a/tests/qtest/bios-tables-test-allowed-diff.h +++ b/tests/qtest/bios-tables-test-allowed-diff.h @@ -1 +1,4 @@ /* List of comma-separated changed AML files to ignore */ +tests/data/acpi/virt/DSDT, +tests/data/acpi/virt/DSDT.memhp, +tests/data/acpi/virt/DSDT.numamem, -- 2.19.1 ...
This graph shows the total number of publications written about Carcinoma, Large Cell by people in Harvard Catalyst Profiles by year, and whether Carcinoma, Large Cell was a major or minor topic of these publication ...
The synchronous primary lung tumors is a rare condition and presented patient is the first reported case of simultaneous two distinct neuroendocrine lung cancer lesions in the same lobe. We present the case of a 55-year-old woman with synchronous two distinct neuroendocrine lung cancer lesions in the right upper lobe. Initially she showed no signs or symptoms related to lung lesions and was admitted to Thoracic Surgery Ward for the investigation of two oval, solitary pulmonary nodules (11 and 19 mm in diameter) detected on a chest X-ray performed three months earlier. The radiological imaging showed a variability of growth of both lesions (smaller tumor has enlarged while the larger one remained unchanged). After the CT-guided lung biopsy, patient underwent right upper lobectomy. Histological examination revealed a small cell carcinoma in one of the tumors and a large cell neuroendocrine carcinoma in the other one. The patient was discharged in good condition and lung inflation in chest X-ray ...
2 MANECs are rare entities known to be associated with biological aggressiveness and poor patient survival, but otherwise remain incompletely characterized.3 In a recent study that compared CRC-NE to conventional colorectal carcinoma, CRC-NE was more frequently located in the right colon (76% vs. 46%), more often presented with metastasis (59% vs. 18%) and often had perineural (68%), lymphatic (97%), and venous (62%) invasion and high tumor budding (71%). BRAF V600E mutation was more common in CRC-NE compared with conventional CRC (53% vs. 12%). Neuroendocrine differentiation, high stage, BRAF mutation without microsatellite instability, and signet ring histology were all associated with poor overall survival.4 In the same study, CRC-NE was further divided into large cell neuroendocrine carcinoma (LCNEC), MANEC composed of LCNEC and conventional adenocarcinoma (MANEC-conventional type), and MANEC composed of LCNEC and signet ring cell carcinoma (MANEC-signet ring type). MANEC-signet ring type ...
ABSTRACT. Background: We reported our experience with thymic carcinomas and review their clinical features, treatment strategies, and prognoses. Methods: From April 1998 to November 2012, 11 patients pathologically diagnosed with thymic carcinoma and treated in our hospital were investigated. Results: There were 7 men and 4 women, with a median age of 62 years (range, 35 - 72). According to the Masaoka staging system, 3 patients had stage II, 1 stage III disease, 3 stage IVa disease and 4 stage IVb disease. Ten patients had squamous cell carcinoma, whereas 1 had large cell neuroendocrine carcinoma (LCNEC). We performed surgery or multimodality therapy including surgery as the initial therapy for 8 patients. Of the non-surgical cases, 1 patient received chemoradiotherapy and survived for over 6 years without recurrence, whereas 2 received palliative care. Three of 4 patients who underwent complete resection survived without disease recurrence, whereas only 1 patient with LCNEC survived in the ...
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously ...
Primary neuroendocrine neoplasms of the lung represent a clinical spectrum of tumors ranging from the relatively benign and slow-growing typical carcinoid to the highly aggressive small-cell lung carcinoma. The rarity of carcinoids has made the role of radiation therapy in their management controversial. This review considers the results of published studies to generate treatment recommendations and identify areas for future research. Surgery remains the standard of care for medically operable disease. Histology plays the most important role in determining the role of adjuvant radiation. Resected typical carcinoids likely do not require adjuvant therapy irrespective of nodal status. Resected atypical carcinoids and large-cell neuroendocrine carcinomas have a significant risk of local failure, for which adjuvant radiation likely improves local control. Definitive radiation is warranted in unresectable disease. Palliative radiation for symptomatic lesions has demonstrated efficacy for all histologies.
Results These 93 patients were referred from 12 hospitals and 20 had undergone previous undiagnostic procedures (6 EBUS, 14 bronchoscopy). The mean age was 67 years (range 27 - 87) and 50 were male. 82 were performed under local anaesthesia using lignocaine spray and intravenous midazolam (1 - 10 mg; mean 4 mgs) and the remaining 11 under general anaesthesia. 200 lymph nodes (2R, 4R, 4L, 7, 10R, 10L, 11R) and 13 lung lesions were biopsied. Results were as follows: Adequate samples were obtained in 99% (91/93) and the NSCLC - NOS rate was 2%. 31 adenocarcinoma, 10 squamous cell carcinoma, 10 small cell carcinoma, 1 NSCLC - NOS, 1 large cell neuroendocrine carcinoma, 1 soft tissue lesion (repeat EBUS showed myxoid spindle cell mesenchymal lesion), 1 breast carcinoma, 19 nonspecific benign nodes, 15 sarcoid and 2 TB. There were no complications. ...
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This study was terminated on March 8, 2010 due to an analysis by an independent Data Safety Monitoring Committee (DSMC) indicating that the addition of CP-751,871 [figitumumab] to erlotinib [Tarceva] would be unlikely to meet the primary endpoint of improving overall survival when compared to erlotinib alone.. This Oncology study continues as terminated, however for ethical reasons some patients, noted with resultant benefit, continue receiving treatment. ...
Non-small cell lung cancer is the most common type of lung cancer. About 85% of lung cancers are non-small cell lung cancers. Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are all subtypes of non-small cell lung cancer.
Non-small cell lung cancer is the most common type of lung cancer. About 85% of lung cancers are non-small cell lung cancers. Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are all subtypes of non-small cell lung cancer.
TY - JOUR. T1 - Patterns of practice survey for nonsmall cell lung carcinoma in the U.S.. AU - Choy, Hak. AU - Shyr, Yu. AU - Cmelak, Anthony J.. AU - Mohr, Peter J.. AU - Johnson, David H.. PY - 2000/3/15. Y1 - 2000/3/15. N2 - BACKGROUND. Nonsmall cell lung carcinoma comprises approximately 75% of all lung carcinoma cases in the U.S. Newly evolving strategies have created considerable controversy regarding the optimal treatment for patients diagnosed with this disease. METHODS. A 17-item survey was designed to collect demographic data and information regarding practice patterns for nonsmall cell lung carcinoma, including patient assessment, treatment approaches, and roles of chemotherapy and radiotherapy. Surveys were mailed in the summer of 1997 to approximately 9200 oncologists of all types throughout the U.S. Practice settings included private office, private hospital, academic, university-affiliated office, government, and Veterans Administration institutions. RESULTS. Approximately 10% of ...
Background: More than 50% of new cases of lung cancer are diagnosed in elderly patients. Does age is a factor for deciding the treatment options? The question remains unsolved even in present era as the median survival time of elderly patients was significantly lower compared with that of younger patients. Methods: We conducted a cross sectional study using data base of 175 patients of primary lung cancer with age 60 years and above diagnosed in indoor and outdoor of the Department of Radiotherapy at Regional Cancer Centre, RIMS, Manipur, India from January 2011 to December 2015. Results: The median age at diagnosis was 70years. There were 113 male (64.6%) patients and 62 female (35.4%) patients. The most common radiological presentation was mass (59.4%) followed by collapse-consolidation (22.8%) and pleural effusion (17.8%). Out of 175 patients, 51% of patients had squamous cell carcinoma, adenocarcinoma (33.7%), large cell carcinoma (9.1%) and undifferentiated carcinoma (6%). The median ...
This phase II trial is studying how well erlotinib works in treating patients with advanced primary non-small cell lung cancer. Erlotinib may stop the g
Lung cancer is the leading killer cancer that starts with the abormal growth and duplication of cells in the lungs.. The sad part is that its symptoms appear only at later stages. Lungs are vital organs of the body that bring in fresh oxygen and distribute it to other parts of the body through blood. Moreover, it aids in expelling out the carbodioxide from the blood as well. Thus, if the lungs are affected by cancer, it can endanger your life, and hence it is essential that you take proper care of your lungs. There are basically two types of lung cancer, small cell lung cancer and non-small cell lung cancer. Nearly fifteen percent cases are of the small cell type. This cancer is seen in the bronchi and is present near the center of the chest. Though small, they multiply and spread really fast . The non-small cell lung cancer occurs in nearly eight five percent cases and has three types, viz., adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.. Causes. Smoking and second hand ...
Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). In order for a LCLC to be subclassified as the rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane. The whorled eosinophilic inclusions in LCLC-RP cells give it a microscopic resemblance to malignant cells found in rhabdomyosarcoma (RMS), a rare neoplasm arising from transformed skeletal muscle. Despite their microscopic similarities, LCLC-RP is not associated with rhabdomyosarcoma. Although rhabdoid variants of LCLC are sometimes referred to as rhabdoid carcinomas, this particular term should be reserved for examples of pure rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) Although Colby and colleagues were the ...
The overall survival of patients treated with either the pemetrexed regimen or gemcitabine regimen was found to be non-inferior, with a median survival of 10.3 months. However, when researchers reviewed survival rates according to histological analysis, it was found that patients with adenocarcinoma achieved 12.6 months of overall median survival when treated with the pemetrexed regimen compared to 10.9 months for those treated with the gemcitabine regimen. Patients with large cell carcinoma who were treated with the pemetrexed regimen achieved 10.4 months of overall median survival versus 6.7 months for those treated with the gemcitabine regimen. Both findings are statistically significant ...
Small round malignant cells that grow rapidly and spread throughout the body. Almost all cases of small cell lung cancer is caused by smoking. Also known as Oat Cell cancer. There are three types of lung cancer: Small Cell (Oat Cell), mixed small cell/large cell carcinoma, and combined small cell carcinoma.
Lung cancer can involve a number of abnormalities of oncogenes and tumor suppressor genes ( 13). Biologically, lung cancers are highly invasive and metastatic tumors ( 19). We have determined that the cytoskeletal protein paxillin had elevated levels of paxillin (compared with normal adjacent lung) in NSCLC, especially with higher stages, implicating it in invasion and metastasis. The gene amplification for PXN was also high in large cell carcinoma (17%) compared with other histologies. Interestingly, MET was highly amplified with or without PXN. Because there is precedence in the literature that there are somatic mutations, such as K-ras and EGFR ( 20, 21), and germ-line mutations, such as c-Met ( 4, 14), for a number of genes, we also investigated whether the paxillin gene could be mutated in lung cancer. Somatic paxillin mutations were identified in lung cancer tumor tissue samples. The mutations were particularly clustered between the LD domains, as well as in the LIM domains. Our current ...
Hi Kelly and all - My name is Paige and Im 38. I was diagnosed Jan. 09 after hysterectomy for fibroids. Unfortunately - due to the surgery plan we had for fibroids, they left in my ovaries, tubes and of course nodes, not knowing the cancer was there. Initially they thought I was 1C with about 65% myometrial invasion and grade 3 hybrid histologic type of large cell/neuroendocrine(small cell) cancer. But I had a PET scan in March that revealed spread to 1 pelvic, 1 paraaortic and 1 portal lymph node (still cant figure out exactly where that is, but have been told its up high behind the liver). So they now consider me stage 3C at a minimum and probably stage 4. All other organs are clear thus far. Started Cisplatin/Etoposide chemo in Feb and just finished 3rd round last week w/3 rounds to go. Will repeat the PET scan next week to see if chemo is working and determine next steps for radiation. Plan is for full abdominal radiation for 6 weeks in the middle of chemo. However I am scared about the ...
Hi Kelly and all - My name is Paige and Im 38. I was diagnosed Jan. 09 after hysterectomy for fibroids. Unfortunately - due to the surgery plan we had for fibroids, they left in my ovaries, tubes and of course nodes, not knowing the cancer was there. Initially they thought I was 1C with about 65% myometrial invasion and grade 3 hybrid histologic type of large cell/neuroendocrine(small cell) cancer. But I had a PET scan in March that revealed spread to 1 pelvic, 1 paraaortic and 1 portal lymph node (still cant figure out exactly where that is, but have been told its up high behind the liver). So they now consider me stage 3C at a minimum and probably stage 4. All other organs are clear thus far. Started Cisplatin/Etoposide chemo in Feb and just finished 3rd round last week w/3 rounds to go. Will repeat the PET scan next week to see if chemo is working and determine next steps for radiation. Plan is for full abdominal radiation for 6 weeks in the middle of chemo. However I am scared about the ...
Exhibits signaling receptor binding activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to localize to the SMN complex; SMN-Sm protein complex; and cytosol. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Is expressed in several structures, including alimentary system; branchial arch; metanephros; nervous system; and sensory organ. Orthologous to human STRAP (serine/threonine kinase receptor associated protein ...
...NEW YORK May 15 2012 /- Reportlinker.com announces that...http://www.reportlinker.com/p0606218/Neuroendocrine-Carcinoma-Therapeu...Neuroendocrine Carcinoma Therapeutics - Pipeline Assessment and Market...GlobalData has estimated that the global neuroendocrine carcinoma ther...,Neuroendocrine,Carcinoma,Therapeutics,-,Pipeline,Assessment,and,Market,Forecast,to,2019,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, EGFR and EML4-ALK, and inactivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes ...
ACPI 3.0 includes UUID-labelled vendor-defined resources (section, so move the code that supports this from arch/ia64 into ACPI proper. Len, Tony, this touches both acpi and ia64. Probably easiest if Tony acks it and Len decides whether to apply it. HP owns all the copyrights on the code being moved, and we agree that the code being moved into the ACPI CA may be used under either the GPL or the BSD-style license used by the ACPI CA. (There should be something in Documentation/acpi about how to contribute to the ACPI CA. Its a royal pain in the rear :-)). Signed-off-by: Bjorn Helgaas ,[email protected], ===== arch/ia64/kernel/acpi-ext.c 1.5 vs edited ===== Index: work-vga2/arch/ia64/kernel/acpi-ext.c =================================================================== --- work-vga2.orig/arch/ia64/kernel/acpi-ext.c 2005-09-14 09:28:07.000000000 -0600 +++ work-vga2/arch/ia64/kernel/acpi-ext.c 2005-09-15 14:52:33.000000000 -0600 @@ -1,105 +1,45 @@ /* - * arch/ia64/kernel/acpi-ext.c + * ...
In this study, we aimed to evaluate the data of patients diagnosed with primary breast neuroendocrine carcinoma. METHODS: Patients with more than 50% neuroendocrine differentiation identified in the histopathological examination between January 2010 and January 2015 and who had no other focus on imaging were evaluated retrospectively from the hospital registry system. Patients with secondary n...
Objective: To investigate the clinicopathologic characteristics, diagnostic features and prognosis of primary renal neuroendocrine carcinoma (NEC). Methods: The clinicopathologic data of eight cases of renal NEC was collected from January 2008 to December 2017 from Affiliated Hospital of Qingdao University.
My brother has very aggressive, widely metastasized neuroendocrine carcinoma. From what I understand, its treated very differently than carcinoids and NETs, which are slow-growing. Im having a horrible time finding a specialist with experience with theaggressiveform. Does anybody know how I find a good specialist? We need help SOON!. ...
Stefano Bacchetti, Enrico Maria Pasqual, Alessandra Rinaldo and Alfio Ferlito-Current Advances in Diagnosis of Hepatic Metastases from Neuroendocrine Carcinomas
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, EGFR and EML4-ALK, and inactivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes ...
Old Synopsis: hw.acpi.thermal.tz0.temperature shows strange value New Synopsis: [acpi] hw.acpi.thermal.tz0.temperature shows strange value Responsible-Changed-From-To: freebsd-bugs-,freebsd-acpi Responsible-Changed-By: linimon Responsible-Changed-When: Fri Jan 20 09:00:34 UTC 2012 Responsible-Changed-Why: Over to maintainer(s). http://www.freebsd.org/cgi/query-pr.cgi?pr=164329 ...
Prof Sandip Patel speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about the DART study, which examined the administrati
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... large cell carcinoma of the lung Clear cell carcinoma of the lung Lymphoepithelioma-like carcinoma of the lung Large-cell lung ... carcinoma with rhabdoid phenotype Large cell neuroendocrine carcinoma of the lung One clinically significant subtype is "large- ... LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher ... Large-cell carcinoma (LCC, LCLC) is a heterogeneous group of undifferentiated malignant neoplasms that lack the cytologic and ...
... (LCNEC) is a highly malignant neoplasm arising from transformed epithelial ... It is currently considered to be a subtype of large cell lung carcinoma. LCNEC is often generically grouped among the non-small ... "combined large cell neuroendocrine carcinoma" (c-LCNEC). Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; ... cell lung carcinomas. The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely " ...
... cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma ... combined large cell neuroencrine carcinoma, and mucinous bronchioloalveolar carcinoma and combined small cell lung carcinoma. ... "Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine ... Chetty R (August 2000). "Combined large cell neuroendocrine, small cell and squamous carcinomas of the lung with rhabdoid cells ...
... squamous cell carcinoma, small cell carcinoma, adenocarcinoma, large cell carcinoma) are treated according to protocols ... Basaloid large cell carcinoma of the lung, is a rare histological variant of lung cancer featuring certain distinctive ... They were first recognized as distinct clinicopathological variants of both squamous cell and large cell lung cancers in 1999, ... September 1992). "Basal cell (basaloid) carcinoma of the lung: a new morphologic and phenotypic entity with separate prognostic ...
Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated ... Only small-cell carcinoma and large-cell carcinoma had shorter average survival.) Most GCCL have already grown and invaded ... By the definition of "large-vs.-small-cell carcinoma", the diameter of GCCL cells must be considerably greater than three times ...
The cells usually contain glycogen with large clear cytoplasm. It is also associated with endometriosis, a disorder of abnormal ... Clear cell ovarian carcinoma is one of several subtypes of ovarian carcinoma. Clear cell is a subtype of epithelial ovarian ... Within this epithelial group clear cell ovarian carcinoma makes up about 5-10%. Clear cell ovarian carcinoma was recognized as ... Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ...
April 2012). "Prognostic factors in a large multi-institutional series of papillary renal cell carcinoma". BJU International. ... 2018-12-28). "Comparison of Prognosis in Types 1 and 2 Papillary Renal Cell Carcinoma and Clear Cell Renal Cell Carcinoma in T1 ... "Clinicopathologic features of renal cell carcinoma in young adults: a comparison study with renal cell carcinoma in older ... Papillary renal cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of ...
There are two types of neuroendocrine carcinomas of the cervix: small-cell and large-cell. Small-cell carcinoma (SCC) of the ... Large-cell carcinoma (LCC), like small-cell carcinoma (SCC) is very rare and only accounts for about 5% of all cervical cancers ... "Because of the distinct natural history of small cell carcinoma of the uterine cervix, and because patients with this condition ... It resembles small-cell cancer of the lungs and accounts for less than 3% of all cervical cancers. Like small-cell cancer in ...
... anaplastic astrocytoma anaplastic large-cell lymphoma anaplastic meningioma anaplastic thyroid cancer (Carcinoma). ... such as the glandular formation or special cellular junctions that are typical of adenocarcinoma and squamous cell carcinoma, ... Anaplastic carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed ... cells of epithelial origin, or showing some epithelial characteristics, but that reveal no cytological or architectural ...
Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... spindle cell carcinoma, and giant cell carcinoma. Giant cell carcinoma components are seen much more commonly in patients who ... December 1982). "The clinical behavior of "mixed" small cell/large cell bronchogenic carcinoma compared to "pure" small cell ... combined small cell carcinoma of the lung has been long classified as a subset of small cell carcinoma, and not as a subset of ...
... such as small cell carcinoma and large cell neuroendocrine carcinoma. The issue of differential diagnosis is particularly acute ... basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct ... A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of ... Basaloid squamous cell carcinoma usually begins centrally, in the larger proximal bronchi. Basaloid carcinoma primary in the ...
These new treatments are based on the fact that renal cell carcinomas are very vascular tumors - they contain a large number of ... renal cell carcinoma and clear cell renal cell carcinoma with smooth muscle stroma Mucinous tubular and spindle cell carcinoma ... cystic clear cell renal cell carcinoma Tubulocystic renal cell carcinoma Thyroid-like follicular renal cell carcinoma Acquired ... The most common cell type exhibited by renal cell carcinoma is the clear cell, which is named by the dissolving of the cells' ...
... (code 8070/3) Large-cell keratinizing squamous cell carcinoma (code 8071/3) Large-cell nonkeratinizing ... Adenoid squamous-cell carcinoma Basaloid squamous-cell carcinoma Clear-cell squamous-cell carcinoma Spindle-cell squamous-cell ... Signet ring-cell squamous cell carcinoma (occasionally rendered as signet ring-cell squamous cell carcinoma) is a histological ... squamous cell carcinoma (code 8072/3) Small-cell keratinizing squamous cell carcinoma (code 8073/3) Spindle-cell squamous cell ...
The median age at diagnosis in a large study was 66 years. Histologically the lesion may coexist with classical endometrial ... Uterine clear-cell carcinoma is staged like other forms of endometrial carcinoma at time of surgery using the International ... Uterine clear-cell carcinoma (CC) is a rare form of endometrial cancer with distinct morphological features on pathology; it is ... "Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers ...
They are susceptible to induced squamous cell carcinoma. They have large litter sizes, and their oocytes possess prominent ... Animals bred for albinism on a large scale, Laboratory mouse strains). ...
... producing large pools of mucus/colloid (optically "empty" spaces). It is poorly differentiated. In signet-ring cell carcinomas ... These may include extranodal marginal zone B-cell lymphomas (MALT type) and to a lesser extent diffuse large B-cell lymphomas. ... Gastric signet ring cell carcinoma. H&E stain. Adenocarcinoma of the stomach and intestinal metaplasia. H&E stain. If cancer ... the mucus remains inside the tumour cell and pushes the nucleus to the periphery, giving rise to signet-ring cells.[citation ...
Spread of cancer cells to local structures like tissues, vessels, large nerves and lymphatics worsens a patient's prognosis.[ ... Carcinoma of the tonsil is a type of squamous cell carcinoma. The tonsil is the most common site of squamous cell carcinoma in ... Squamous cell carcinoma was the most common reported cell type (88%); cases with Lymphoepithelioma had the highest incidence of ... Squamous Cell Carcinoma of the Tonsil)". MyVMC.com. 2003-01-08. Retrieved 2016-07-16. Mankekar, G. (2000). "Tonsillar carcinoma ...
... a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells ... Signet ring cells (magenta) stained with PAS in a gastric signet ring cell carcinoma. A significant number of signet ring cells ... signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring stromal cell The name of the cell comes ... They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell ...
Radiation therapy is the primary management of Merkel cell carcinoma (MCC). The largest series we have are from Australia and ... squamous cell carcinoma, malignant melanoma, lymphoma, and small cell carcinoma, or as a benign cyst. Merkel cell carcinomas ... Media related to Merkel cell carcinoma at Wikimedia Commons National Cancer Institute. "Merkel Cell Carcinoma". National ... "Immunotherapy for Merkel Cell Carcinoma , Merkel Cell Carcinoma". Retrieved 2020-05-14. Clinical trial number NCT01913691 for " ...
Tocilizumab was first used in large-cell lung carcinoma. In phase I/II trial of tocilizumab in ovarian cancer EGFR pathway ... However, it has become evident that eccentric exercises are not associated with a larger increase in plasma IL-6 than exercise ... of patients with metastatic castration-associated prostate cancer in combination with docetaxel and in renal cell carcinoma; ...
... small-cell lung cancer (SCLC) large cell neuroendocrine carcinoma of the lung (LCNEC) Extrapulmonary small cell carcinomas ( ... neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. Additionally, the WHO scheme ... "Large cell carcinoma of the lung with neuroendocrine differentiation. A comparison with large cell "undifferentiated" pulmonary ... mixed exocrine-neuroendocrine carcinoma (goblet cell carcinoma, also called adenocarcinoid and mucous adenocarcinoid) Hindgut ...
The most common types of NSCLC are squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma, but several other types ... Popper HH (2011). "Large cell carcinoma of the lung - a vanishing entity?". Memo - Magazine of European Medical Oncology. 4: 4- ... Large-cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed ... Non-small-cell lung cancer (NSCLC) is any type of epithelial lung cancer other than small-cell lung carcinoma (SCLC). NSCLC ...
ISBN 978-0-7216-0187-8. Mulvany NJ, Allen DG (January 2008). "Combined large cell neuroendocrine and endometrioid carcinoma of ... Endometrioid carcinoma can also arise in the endometrium. Grades 1 and 2 are considered "type 1" endometrial cancer, while ... Carcinoma,+Endometrioid at the US National Library of Medicine Medical Subject Headings (MeSH) "ACS :: What Is Endometrial ... Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third ...
Malignancy is rare and constitutes only 2% of all granular cell tumors. List of cutaneous conditions Glassy cell carcinoma ... Granular cell tumors are typically solitary and rarely larger than three centimeters. However, proliferative growth and ... It is also known as Abrikossoff's tumor, granular cell myoblastoma, granular cell nerve sheath tumor, and granular cell ... The tumor cells stain positively for S-100 as they are of Schwann cell origin. Both malignant and benign versions of the tumor ...
"Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". Journal of Immunology. 169 ... This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, ... "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the ... Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( ...
Overview at Mayo Clinic Large Cell and Giant Cell Carcinoma,+Giant+Cell at the US National Library of Medicine Medical Subject ... and giant cell fibroblastoma. Medicine portal Anaplastic large-cell lymphoma Buttock cell Nosology Giant+Cell+Tumors at the US ... Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are ... The phrase giant cell is also frequently used, especially with carcinoma. Giant cell tumors include giant-cell tumor of bone, ...
The rate of incidence varies from 0.5 to 4%. Cytologically, the cells of apocrine carcinoma are relatively large, granular, and ... When apocrine carcinoma is tested as a "triple negative", it means that the cells of the patient cannot express the estrogen ... Apocrine ductal carcinoma in situ (ACDIS) is a very rare breast carcinoma which is regarded as a variant of the ductal ... In apocrine secretion, secretory cells accumulate material at their apical ends, and this material then buds off from the cells ...
... with squamous cell carcinomas comprising one of the largest subsets. All squamous cell carcinoma lesions are thought to begin ... can also be used to treat squamous cell carcinomas. Squamous cell carcinoma of eye tissues is one of the most frequent ... squamous cell carcinoma. Once a carcinoma becomes invasive, it is able to spread to other organs and cause a metastasis, or " ... Most conjunctival squamous cell carcinomas are removed with surgery. A few selected cases are treated with topical medication. ...
Cure rate can be as high as 95% for small tumor, or as low as 80% for large tumors. A variation of an external brachytherapy is ... Basal cell carcinoma on patient's back Basal-cell carcinoma Basal cell carcinoma on the left upper back, nodular and ... squamous cell carcinoma. In a small proportion of cases, basal-cell carcinoma also develops as a result of basal-cell nevus ... Nodular basal-cell carcinoma (also known as "classic basal-cell carcinoma") accounts for 50% of all BCC. It most commonly ...
In 1879, Arnold examined sarcoma and carcinoma cells having very large nuclei. Today, the study of molecular cytogenetics can ... Removing the cell culture and isolation step dramatically simplifies and expedites the process. Using similar principles to CGH ... Cancer cells often accumulate complex chromosomal structural changes such as loss, duplication, inversion or movement of a ... FISH allows one to visualize different parts of the chromosome at different stages of the cell cycle. FISH can either be ...
... carcinoma Small cell carcinoma Neuroendocrine tumour Glassy cell carcinoma Villoglandular adenocarcinoma Though squamous cell ... Larger early-stage tumors (IB2 and IIA more than 4 cm) may be treated with radiation therapy and cisplatin-based chemotherapy, ... Histologic subtypes of invasive cervical carcinoma include: Squamous cell carcinoma (about 80-85%) adenocarcinoma (about 15% of ... About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. ...
Epithelial cells lining the fronds' inner surfaces commonly form solid, cribriform (i.e. large nests of cells perforated by ... These cells, which are not myoepithelial cells, have been termed globoid cells. They have eosinophilic cytoplasm (i.e. pink or ... Rarely, invasive SPC occurs with nearby invasive carcinoma of NST, lobular carcinoma, cribriform carcinoma, or tubular ... mucinous carcinoma, or tubular carcinoma tumors. Immunohistochemical analyses of the tumors cells in most individuals with EPC ...
Vacuolated, or clear cells are common. Necrosis or cell death is normally observed to some extent in most of these tumors cells ... A larger number of cases that contain a longer clinical follow-up are needed to optimize the management of patients with this ... and metastatic papillary carcinoma. Papillary tumors characteristically show a discrete, compressive border with adjacent ... If the abnormal cells continue to grow, divide, and produce more abnormal cells, the mass of abnormal cells may eventually ...
Cell. 176 (5): 952-965. doi:10.1016/j.cell.2019.01.043. PMID 30794780. Wood AJ, Oakey RJ (November 2006). "Genomic imprinting ... gene in sheep produces large buttocks consisting of muscle with very little fat. The large-buttocked phenotype only occurs when ... an imprinted putative tumor suppressor gene in ovarian and breast carcinomas". Proceedings of the National Academy of Sciences ... of the parents and are maintained through mitotic cell divisions in the somatic cells of an organism. Appropriate imprinting of ...
... which result from the formation of large vacuoles full of mucin that displaces the nucleus to the cell's periphery. Stomach ... "Signet ring cell colorectal carcinoma: a distinct subset of mucin-poor microsatellite-stable signet ring cell carcinoma ... The pattern of metastasis is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. The SRCC ... cell-cell interactions are lost and signet carcinomas are formed. Constitutive action of the ErbB2/ErbB3 complex also enhances ...
... in Current Science Glyceraldehyde-3-phosphate dehydrogenase from Earlich Ascites Carcinoma cells: its possible role in the high ... Jnan Chandra Ghosh Memorial Award Ray has published a large number of scientific papers as lead author in association with ... From a putative intermediate of glucose breakdown to its role in understanding that excessive ATP formation in cells may lead ... glycolysis of malignant cells (1999) in European Journal of Biochemistry "Manju Ray". Indian Association for the Cultivation of ...
The compound was found to be minimally toxic to human cells with an IC50 of 70 mg/L against human carcinoma cells. It has been ... This occurs via a spontaneous [4+2] cycloaddition after module 8 (See Figure 2). Cyclization to form the larger lactone ring is ...
He produced large amounts of human alpha interferon from large quantities of human white blood cells collected by the Finnish ... Control of chronic hepatitis C by IFN is associated with reduced hepatocellular carcinoma. Unconfirmed results suggested that ... A virus-infected cell releases viral particles that can infect nearby cells. However, the infected cell can protect neighboring ... and its expression is restricted to immune cells such as T cells and NK cells. All interferons share several common effects: ...
... carcinoid Pulmonary Typical bronchial carcinoid Atypical bronchial carcinoid Large cell neuroendocrine carcinoma Small cell ... tumors Non-functioning endocrine pancreatic tumors Insulinoma Gastrinoma Glucagonoma VIPoma Adrenals Adrenocortical carcinoma ...
Cell. Biol. 26 (3): 976-89. doi:10.1128/MCB.26.3.976-989.2006. PMC 1347043. PMID 16428451. Sarai N, Kagawa W, Kinebuchi T, et ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... 2007). "Loss of heterozygosity in the RAD54B region is not predictive for breast carcinomas". Pol J Pathol. 58 (1): 3-6. PMID ... In a pre-clinical study, colon cancer cells defective in RAD54B were determined to be selectively killed by inhibitors of the ...
Carcinogenicity The carcinogenicity of aflatoxin B1, which is characterized by the development of liver cell carcinoma, has ... To date this was the largest known outbreak of aflatoxosis in terms of fatalities documented. "AFLATC : Aflatoxin B1 chloroform ... and hepatic carcinoma. Other liver lesions include enlargement of hepatic cells, fatty infiltration, necrosis, hemorrhage, ... Prevalence of hepatocellular carcinoma in individuals exposed to aflatoxin, increases with co-infection of hepatitis B virus. ...
The genes that currently have evidence to be associated with CMM disorder include DCC (deleted in colorectal carcinoma), DNAL4 ... "Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline". Scientific Reports. 7 (1): 410. ... "Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large ... a protein thought to be responsible for axon guidance and neuronal cell migration during development. A mutation of this gene ( ...
2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. ... 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456-64. doi: ... doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. v t e (Genes on human chromosome 12, All stub articles, Human ... Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol. 18 (2 ...
... in Participants With Progressive Locally Advanced or Metastatic Carcinoma, Melanoma, or Non-small Cell Lung Carcinoma (P07990/ ... This was the largest Phase I study ever run in oncology, with the patients roughly divided between melanoma and lung cancer. In ... Results of a Phase II clinical trial in Merkel-cell carcinoma were reported in The New England Journal of Medicine in June 2016 ... the first-line treatment of metastatic non-small cell lung carcinoma (NSCLC) in adults whose tumors express PD-L1 with a ≥ 50% ...
"Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines". International Journal of ... "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. ... Moreover, galectin-9 contributed to tumorigenesis by tumor cell transformation, cell-cycle regulation, angiogenesis, and cell ... and hepatocellular carcinoma. HAVCR2/ galectin-9 interaction attenuated T-cell expansion and effectors function in tumor ...
... gene transcripts of a large number of tumor cell lines and primary tumors. The laboratory also focuses on functional ... from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal stromal tumors. 2005 ... The simultaneous inhibition of these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ... suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor ...
Even rarer neoplasms include sarcoma, squamous cell carcinoma, yolk sac tumor, neuroendocrine carcinoma, paraganglioma, ... When viewed under a microscope, the cells are seen to have large bubbles in their interior. This is because their interior, ... The large cyan-coloured area is the bladder, and the lobulated smaller structures below it are the vesicles. Seminal vesicles ... Sertoli cells secrete anti-mullerian hormone, which causes the paramesonephric duct to regress. The development and maintenance ...
... but nevertheless infiltrative basal cell carcinoma may have the need to remove a large part of the scalp.[citation needed] On ... As the incidence of basal-cell carcinoma and squamous-cell carcinoma is rising and about 80% are located in the head and neck ... As the incidence of basal cell carcinoma and squamous-cell carcinoma rises, so does the need for reconstructions after radical ... All large blood vessels and nerves of the scalp are located in this layer. The next layer is the galea Aponeurotica, which ...
... most cells looked fairly normal and there was no evidence of mitosis which would indicate that cells were rapidly dividing), ... While the majority of these cases are associated with appendiceal carcinomas, other conditions may also be found, including ... and parts of the large intestine. Depending upon the spread of the tumor, other organs might be removed, including but not ... irregular cells, evidence that cells were rapidly dividing, and other criteria), with or without an associated primary mucinous ...
Hemosiderosis is hemosiderin deposition within cells, while hemochromatosis is hemosiderin within cells and interstitium. ... Diet and the environment are thought to have had large influence on the mutation of genes related to iron overload. Starting ... The presence of cirrhosis increases the risk of hepatocellular carcinoma. HHC is most common in certain European populations ( ... metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in the ...
... most commonly in children Squamous cell carcinoma - may develop at the rate of 2 to 15% of the chronic ulcers that persists for ... Large infected ulcers may require debridement under anesthesia. Skin grafting may be helpful in advanced cases to ensure the ... Chronic ulcers involve larger area and may eventually develop into squamous epithelioma after 10 years or more. Skin color: ...
The use of cell culture in early development has become a requirement for assessing the basic efficacy of a drug candidate. ... The most obvious are their large size and propensity to degradation by nucleases. In order for cellular RNA to be effective it ... and hepatocellular carcinoma. More recently, the Disney group further used their prediction database INFORNA to design ... However, recent reports have shown that there are a large number of non-coding RNAs (ncRNAs) that are not translated into ...
... that is involved in cell proliferation of esophageal squamous cell carcinoma". J. Biol. Chem. 280 (20): 19977-85. doi:10.1074/ ... which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. ... "Quantitative proteomic analysis of mitochondria from human ovarian cancer cells and their paclitaxel-resistant sublines". ...
... "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): ... 2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076-86. doi: ... 2003). "Mutational analysis of salvador gene in human carcinomas". APMIS. 111 (6): 595-8. doi:10.1034/j.1600-0463.2003.1110601. ... Cell. Proteomics. 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. Callus BA, Verhagen AM, Vaux DL (2006). " ...
Colonoscopy may be used to examine the large intestine, and a person's stool may be sent for culture and microscopy. Infectious ... Congenital disorders of the stomach include pernicious anaemia, in which a targeted immune response against parietal cells ... "Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments". World Journal of ... Generalised inflammation of the large intestine is referred to as colitis, which when caused by the bacteria Clostridium ...
Côté JF, Vuori K (August 2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends in Cell ... Dock11 (Dedicator of cytokinesis), also known as Zizimin2, is a large (~240 kDa) protein involved in intracellular signalling ... "Improved gene expression signature of testicular carcinoma in situ". International Journal of Andrology. 30 (4): 292-302, ... Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". Journal of Cell Science. 118 (Pt 21): ...
Patients were diagnosed with histopathologically confirmed squamous cell carcinoma of the skin or head and neck. One-hundred ... Additional studies in larger populations are now ongoing to strengthen support regarding the safety and effectiveness of this ... This capability does not seem to be dependent on the stage of the cell cycle or the level of oxygenation of the cancer cell.[ ... "Growth retardation and destruction of experimental squamous cell carcinoma by interstitial radioactive wires releasing ...
"MAL expression in lymphoid cells: further evidence for MAL as a distinct molecular marker of primary mediastinal large B-cell ... "Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal, ... The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal ... "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". Journal of Cell Science. 117 (Pt ...
... s can be defined as an irregular neck mass or a lump which develops from cells and tissues left over after the ... Ali M.; Abussa A.; Hashmi H. (2007). "Papillary thyrpid carcinoma formation in a thyroglossal cyst. A case report". Libyan ... especially if the cyst becomes large.[citation needed] The most common location for a thyroglossal cyst is midline or slightly ... These tumors are generally papillary thyroid carcinomas, arising from the ectopic thyroid tissue within the cyst. Thyroglossal ...
W. Meyer, "An improved method of the radical operation for carcinoma of the breast", New York Medical Record, vol. 46, pp. 746- ... However, post-operation morbidity rates were high as the large wounds were left to heal by granulation, lymphedema was ... It was thought that hematic spread of tumor cells occurred at a much later stage. Halsted himself believed that cancer spread ... Handley, R. S.; Thackray, A. C. (1954-01-09). "Invasion of Internal Mammary Lymph Nodes in Carcinoma of the Breast". British ...
Learn about the differences between small and large cell lung carcinomas, how LCLC is diagnosed and treated, and more. ... is one form of non-small cell lung cancer that can grow quickly and spread aggressively. ... Squamous cell carcinoma. Squamous cell carcinoma is another large cell carcinoma and is sometimes referred to as epidermoid ... Large cell carcinoma. This type of lung cancer is named so because of its large, abnormal-looking cells. These cells can be ...
Two distinct populations of Merkel cell carcinoma identified; both exhibit similar responses to immunotherapy ... "This study represents the largest description of the genomic landscape of Merkel cell carcinoma. The magnitude of this study ... Merkel cell carcinoma (MCC) is a rare, aggressive skin tumor that is diagnosed in approximately 2,000 people each year in the ... Additionally, DNA and proteins from the virus Merkel cell polyomavirus (MCPyV) are present in many patients with MCC, and it is ...
... well differentiated squamous cell carcinoma. The tumour measured 9 cm in length and 6 cm in diameter. The carcinoma invaded ... Biopsy showed invasive, well differentiated squamous cell carcinoma. An inguinal ultrasound was negative for lymphadenopathy. A ...
Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine lung tumors. Here we provide an overview ... Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine lung tumors. Here we provide an overview ... New Insights into the Molecular Characteristics of Pulmonary Carcinoids and Large Cell Neuroendocrine Carcinomas, and the ...
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic Large Cell Neuroendocrine Carcinoma ( ... TCR beta chain convergence defines the tumor infiltrating T cell repertoire of melanoma and non-small cell lung carcinoma.. ... Tumors were scored positive if > 1% of tumor cells showed any membranous staining. Overall survival (OS) was evaluated by ...
... squamous carcinoma, and large cell carcinoma) compared with controls. Statistically significant increase in splenic malignant ... Large cell carcinoma. 1 rat. The tumor found in the control rat was an adenoma. The authors concluded that the significantly ... Significantly increased incidence of adenomas, benign squamous cell cysts, and squamous cell carcinoma of the lung when ... Statistically significant increase in lung tumors (adenoma, squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma) ...
Primary Mediastinal Large B-Cell Lymphoma KEYTRUDA is indicated for the treatment of adult and pediatric patients with ... Renal Cell Carcinoma KEYTRUDA, in combination with axitinib, is indicated for the first-line treatment of adult patients with ... Merkel Cell Carcinoma KEYTRUDA is indicated for the treatment of adult and pediatric patients with recurrent locally advanced ... Cutaneous Squamous Cell Carcinoma KEYTRUDA is indicated for the treatment of patients with recurrent or metastatic cutaneous ...
It usually grows and spreads more slowly than small cell lung cancer. ... Non-small cell lung cancer is the most common type of lung cancer. ... Non-small cell lung cancer; NSCLC; Adenocarcinoma - lung; Squamous cell carcinoma - lung; Large cell carcinoma - lung ... Large cell carcinomas can occur in any part of the lung.. *There are more uncommon types of lung cancer that are also called ...
Squamous cell carcinoma in left flank due to saree: Largest reported case. International Journal of Research in Medical ... Squamous cell carcinoma in left flank due to saree: Largest reported case.. en_US. ... biopsy was taken and it showed squamous cell carcinoma (SCC). We decided to do wide excision with tension free suturing. Post ... This turns out to be the third case being reported and the largest ever to be reported in the literature.. en_US. ...
... that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). The prognosis for patients ... Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) ... Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study on a large series of cases. Br J ... Nodular basal cell carcinoma. Nodular basal cell carcinoma is the most common type of basal cell carcinoma and usually presents ...
Among both smoking and nonsmoking populations of underground miners, small-cell carcinoma occurs at a higher frequency in the ... Large cell carcinoma, and. *Squamous cell carcinoma.. Top of Page. Reproductive Effects ... When progeny transform within the lungs and their energy deposits in tissue (and not fluid), the genetic material of cells ... Cancer is a monoclonal disease that starts as a single cell with heritable damage to the deoxyribonucleic acid (DNA); this ...
Alectinib and mixed large cell neuroendocrine carcinoma of the lung.] [Alectinib and mixed large cell neuroendocrine carcinoma ... The treatment of mixed large cell neuroendocrine carcinoma is less studied due to its low incidence. However, the presence of ... Histological examination identified metastasis of large cell neuroendocrine carcinoma. Revision and molecular examination of ... Carcinoma de Células Grandes/tratamento farmacológico; Carcinoma de Células Grandes/genética; Carcinoma Neuroendócrino/ ...
... PubMed, SCI, Scopus, ... Albores-Saavedra J, Martinez-Benitez B, Luevano E. Small cell carcinomas and large cell carcinomas of the endometrium and ... LCNEC are diagnosed based on large cell carcinoma; large cell size with low nuclear to cytoplasm ratio, , 10 mitotic counts in ... and further categorized into small and large cell neuroendocrine carcinomas. Approximately only 90 cases of small cell ...
Large cell carcinoma. This is an uncommon type of lung cancer, accounting for less than 10% of cases ... There are different kinds of lung cancer. About 80% to 85% of lung cancer diagnoses are non-small cell lung cancer (NSCLC), and ... Squamous cell cancer. This is more commonly linked to a history of smoking. It develops in the airways of the lungs. ... Small cell lung cancer (SCLC) accounts for around 10% to 15% of all lung cancers and very rarely develops in someone who has ...
Primary Mediastinal Large B-Cell Lymphoma. Indicated for refractory primary mediastinal large B-cell lymphoma (PMBCL), or who ... Merkel Cell Carcinoma. Indicated for treatment of recurrent, locally advanced, or metastatic Merkel cell carcinoma (MCC) ... Primary Mediastinal Large B-Cell Lymphoma. Indicated for refractory primary mediastinal large B-cell lymphoma (PMBCL), or ... Merkel Cell Carcinoma. Indicated for treatment of recurrent, locally advanced, or metastatic Merkel cell carcinoma (MCC) ...
Undertaking such an approach in human lung adenocarcinoma, squamous cell carcinoma, and large-cell carcinoma samples, we noted ... squamous cell carcinoma, and large-cell carcinoma in 50% (n = 53), 37% (n = 36), and 10% (n = 10) of patients, respectively. ... squamous cell carcinoma, and large-cell carcinoma were assessed using seven-color multiplex fluorescence staining (Fig. 3A and ... squamous cell carcinoma, and large-cell carcinoma are the major histologic subtypes. Recent studies suggest the tumor ...
Do you qualify for these Large Cell Lung Carcinoma studies? Were researching new and effective treatments. ... Large Cell Lung Carcinoma clinical trials at UCSD 4 in progress, 1 open to eligible people ... Our lead scientists for Large Cell Lung Carcinoma research studies include Lyudmila A. Bazhenova. ... Cetuximab may also stop cancer cells from growing by binding and interfering with a protein on the surface of the tumor cell ...
Primary Mediastinal Large B-Cell Lymphoma KEYTRUDA is indicated for the treatment of adult and pediatric patients with ... Renal Cell Carcinoma KEYTRUDA, in combination with axitinib, is indicated for the first-line treatment of adult patients with ... Merkel Cell Carcinoma KEYTRUDA is indicated for the treatment of adult and pediatric patients with recurrent locally advanced ... Cutaneous Squamous Cell Carcinoma KEYTRUDA is indicated for the treatment of patients with recurrent or metastatic cutaneous ...
... and three were large cell undifferentiated carcinomas. Among the 25 lung cancer patients, 17 were smokers at the time of ... nine were small cell anaplastic carcinomas; six were adenocarcinoma, bronchogenic type; two were adenocarcinoma, bronchiolar ... In 25 of the cases, the primary site of malignancy was the lung: five of these malignancies were epidermoid carcinomas; ... Histopathologic classification of bronchogenic carcinomas among a cohort of workers occupationally exposed to beryllium. ...
Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and ... Cell Immunol, 2017 Aug. PMID 28651742 * STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Huh HD ... Cell Cycle, 2014. PMID 25485581, Free PMC Article * Serine threonine receptor-associated protein (STRAP) plays a role in the ... A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, ...
Large liver cell adenoma -Consideration in the differential diagnosis with well-differentiated hepatocellular carcinoma-. In: ... Large liver cell adenoma -Consideration in the differential diagnosis with well-differentiated hepatocellular carcinoma-. / ... Large liver cell adenoma -Consideration in the differential diagnosis with well-differentiated hepatocellular carcinoma-. ... T1 - Large liver cell adenoma -Consideration in the differential diagnosis with well-differentiated hepatocellular carcinoma- ...
Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). The ... Genetic and Rare Diseases Information Center resources: Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma ... Carcinoma. Carcinoma, Renal Cell. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Adenocarcinoma ... clear cell renal cell carcinoma (ccRCC).. This substudy will have two phases: a safety lead-in phase and an efficacy phase. The ...
Garlic and General Feedback for Basal Cell Carcinoma treatment. ... I have had basal cells, dark black spots as large as a dime in ... The 70 year old gentleman with the large facial basal cell carcinoma should have it treated by a radiation oncologist (NOT a ... I have a basal cell carcinoma on my lower lip. You can hardly see it becuase I think its under skin. I wonder how to treat ... Large facial basal cells can become infiltrative and burrow deep into the skin. In a few weeks of facial radiation treatments ( ...
Primary Signet Ring Cell Carcinoma. Primary Signet Ring Cell Carcinoma of the appendix is a very rare cancer. According to the ... The combination of CHOP and rituximab is now the standard of care for large B-cell lymphoma in the US. For Burkitts lymphoma, ... In a study done by Pahlavan and Kanthanon adenocarcinoid tumors, he states that even though Goblet cell carcinoma is an ... carcinoma-like) [3]. In 1914, Dr Gosset and Dr Mason postulated that carcinoid tumors were made up of enterochromaffin cells, a ...
Small or large cell carcinoma. *Intraductal oncocytic papillary neoplasms. *Osteoclast-like giant cell tumors ... mesothelin-specific T-cell response, and the degree of local eosinophil, macrophage, and T-cell infiltration at the vaccine ... Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. Drugs ... and T cell infiltration at the vaccine site, and mesothelin-specific T cell responses. ...
Somatostatin receptors affect the expression of normal and malignant cells. The purpose of the study was to compare the ... Large-cell neuroendocrine carcinoma (LCNEC) without pulmonary symptoms diagnosed in a cutaneous metastasis Cai Yuan, Benjamin ... Lung Large Cell Neuroendocrine Carcinoma: An Analysis of Patients from the Surveillance, Epidemiology, and End-Results (SEER) ... A Case of Gastric Cancer with Neuroendocrine Carcinoma, Signet Ring Cell Carcinoma Components, and Intramural Metastases ...
... carcinoma is included with carcinoma, not otherwise specified (NOS); when using ICD-O, 1976, large cell carcinoma is a separate ... and lobular carcinoma 8523/3 Infiltrating duct carcinoma and lobular carcinoma in situ 8524/3 Intraductal carcinoma and lobular ... The codes are: 5 T-cell 6 B-cell 7 Null cell 18 Diagnostic Confirmation ITEM NUMBER/NAME: 18 Diagnostic Confirmation LENGTH: 1 ... In the early 1980s, additional codes specifying T-cell, B-cell, or null cell involvement in lymphomas and leukemias ( ...
  • Adenocarcinoma is the most common type of lung cancer and is classified as a non-small cell lung cancer . (healthline.com)
  • Our case report would like to draw attention to the evaluation of driver mutations in pulmonary mixed neuroendocrine carcinoma with adenocarcinoma component because targeted treatment may be an effective alternative. (bvsalud.org)
  • The majority of appendiceal tumors are carcinoids, while the remaining 10% to 20% are mucinous cyst-adenocarcinoma, adenocarcinoma, lymphosarcoma, paraganglioma, and granular-cell tumors. (hindawi.com)
  • Large cell neuroendocrine carcinoma of the ileocecal junction with well differentiation adenocarcinoma. (nel.edu)
  • Wang X, Li Y, Feng H, Wang C, Chen J, Liu L. Large cell neuroendocrine carcinoma of the ileocecal junction with well differentiation adenocarcinoma. (nel.edu)
  • Within the group of non-small cell cancer there are further subdivisions into adenocarcinoma and squamous cell carcinoma, and large cell carcinoma, but generally we talk about small cell and non-small cell carcinoma and they behave differently and they are treated differently. (empowher.com)
  • The Group confirmed the previous evaluation of the IARC Handbooks (Volume 6, 2002) that absence of excess body fatness reduces the risk of cancers of the colon and rectum, oesophagus (adenocarcinoma), kidney (renal cell carcinoma), breast in postmenopausal women, and endometrium of the uterus. (who.int)
  • This is a common term used for many types of lung cancers such as adenocarcinoma, squamous and large cell carcinoma. (lamedtrip.com)
  • There are two types of esophageal cancer, each with different risk factors: Adenocarcinoma -Cancers that start in gland cells at the bottom of the esophagus are called adenocarcinomas. (secunderabadchronicle.in)
  • Carcinoids and large cell neuroendocrine carcinomas (LCNECs) are rare neuroendocrine lung tumors. (nih.gov)
  • Neuroendocrine tumors are classified as poorly-differentiated and well differentiated, and further categorized into small and large cell neuroendocrine carcinomas. (fortunejournals.com)
  • Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. (ucsd.edu)
  • Neuroendocrine tumors are unique and rare tumors originating from neuroendocrine cells. (nel.edu)
  • Large cell neuroendocrine tumors have been found. (nel.edu)
  • Gastric neoplasms containing neuroendocrine carcinoma (NEC) components are rare malignancies with highly aggressive behavior and a poor prognosis and include pure NEC and mixed tumors containing NEC components. (biomedcentral.com)
  • For those mixed tumors with less than 30% or more than 70% neuroendocrine carcinoma components, there is no uniform definition. (biomedcentral.com)
  • The malignancy involves the kidney (renal cell carcinoma) and present with large tumors of the kidney that has usually metastasized by the time it is diagnosed. (bellaonline.com)
  • NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. (spandidos-publications.com)
  • Lung neuroendocrine tumors (LNETs) are a group of rare tumors with heterogenous malignancy originating in amine precursor uptake and decarboxylation (APUD) neuroendocrine cells from Kulchitsky cells (argentaffin cells) ( 1 ). (spandidos-publications.com)
  • Azzopardi introduced the term of oat cell carcinoma in 1959 after a study on 100 cases of pulmonary tumors ( 4 ). (spandidos-publications.com)
  • The neuroendocrine cells from which neuroendocrine tumors (NETs) derive are located in numerous places in the human body ( 8 ). (spandidos-publications.com)
  • Tessa's core virus-specific T cell (VST) platform has shown compelling results in the treatment of solid tumors, and the company is building a portfolio of therapies addressing a wide range of tumors by combining the qualities of its T cell platform with complementary technologies. (edbi.com)
  • CT of the chest should be used to detect pulmonary metastasis in patients with large or locally advanced tumors. (medscape.com)
  • 2018). Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. (who.int)
  • Kura is conducting a Phase 1/2 trial (KURRENT-HN) of tipifarnib in combination with the PI3Kα inhibitor alpelisib to address larger genetic subsets of HNSCC patients, including those whose tumors are dependent on HRAS and/or PI3Kα pathways. (wjbf.com)
  • CX-2029, co-developed by CytomX and AbbVie is a PDC directed against CD71, the transferrin receptor which is highly expressed on a number of solid and hematologic tumors, including diffuse large B-cell lymphoma and also Esophageal Cancer. (secunderabadchronicle.in)
  • Tumors were classified according to cell type, location, and the presence of asbestos fibers while other features of the lungs were also noted. (cdc.gov)
  • Of the 50 asbestos related cancers, 11 were adenocarcinomas, 6 were anaplastic large cell tumors, 8 showed a combination of cell types, and 3 were unclassified. (cdc.gov)
  • By observing shared transcriptomic and epigenetic changes across a large and diverse set of tumors, this analysis identifies those shared signals that are likely to be important for both the onset and progression of cancer cells. (escholarship.org)
  • Small-cell lung cancer is particularly difficult to treat because the cancer spreads rapidly throughout the body, rather than forming large tumors that can be removed surgically. (dailyramblingsofaprofessionalnetworker.com)
  • Lynch syndrome was recognized in tumors rarely or not previously associated with Lynch, including prostate, sarcoma, mesothelioma, adrenocortical carcinoma, and even in young patients with ovarian germ-cell tumors," she said. (ahdbonline.com)
  • Oral cancer is a wide-ranging category of location for neoplasms and includes tumors of different etiologies and histopathological profiles, although the vast majority relate to squamous-cell carcinoma (SCC) [1]. (bvsalud.org)
  • Kura has demonstrated encouraging clinical activity in HRAS-mutant head and neck squamous cell carcinoma (HNSCC) via farnesyl transferase inhibition with tipifarnib and is currently evaluating tipifarnib in combination with the PI3Kα inhibitor alpelisib to address larger genetic subsets of HNSCC patients. (wjbf.com)
  • Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). (jomfp.in)
  • In the first part, I exploit the comprehensive, multi-omics profiling provided by The Cancer Genome Atlas to conduct an analysis of the molecular and clinical features of head and neck squamous cell carcinoma (HNSCC) that govern patient survival. (escholarship.org)
  • There remains up to a 50% recurrence rate in advanced p16- head and neck squamous cell carcinoma with current standard of care treatment. (biomedcentral.com)
  • To survey the landscape of active neoadjuvant immunotherapy trials in head and neck squamous cell carcinoma and summarize and synthesize currently available outcomes from these trials. (biomedcentral.com)
  • Neoadjuvant immunotherapy has proven safe and well tolerated in head and neck squamous cell carcinoma with encouraging efficacy results, including relatively high rates of pathologic response. (biomedcentral.com)
  • We await updated reports of disease free survival and overall survival data and results of ongoing phase III studies utilizing neoadjuvant immunotherapy to determine if this treatment paradigm will have a place in the standard of care treatment in head and neck squamous cell carcinoma. (biomedcentral.com)
  • Current standard of care treatment for patients with locoregionally advanced head and neck squamous cell carcinoma (HNSCC) is either definitive chemoradiotherapy (CRT) or surgical resection followed by adjuvant radiation with the addition of radiosensitizing chemotherapy when high risk features are noted on final pathology. (biomedcentral.com)
  • Squamous cell carcinoma. (healthline.com)
  • Squamous cell carcinoma is another large cell carcinoma and is sometimes referred to as epidermoid carcinoma. (healthline.com)
  • Squamous cell carcinomas make up about one-quarter of all non-small cell lung cancers. (healthline.com)
  • Biopsy showed invasive, well differentiated squamous cell carcinoma. (bmj.com)
  • The pathological specimen showed an invasive, well differentiated squamous cell carcinoma. (bmj.com)
  • Squamous cell carcinomas are usually found in the center of the lung next to an air tube (bronchus). (medlineplus.gov)
  • IMSEAR at SEARO: Squamous cell carcinoma in left flank due to saree: Largest reported case. (who.int)
  • Here we present a case of 60 year old female who presented with left flank ulcer following chronic irritation from saree, biopsy was taken and it showed squamous cell carcinoma (SCC). (who.int)
  • Squamous cell cancer. (cancer.net)
  • and squamous cell neoplasm. (nih.gov)
  • Gross postmortem photograph of the esophagus of a horse with extensive squamous cell carcinoma, accompanied by ulceration. (merckvetmanual.com)
  • Squamous cell carcinoma of the larynx. (pagosasun.com)
  • Squamous cell carcinoma of the trachea. (pagosasun.com)
  • Squamous Cell And Large-Cell Undifferentiated Carcinomas, What Are They? (empowher.com)
  • NSCLC histologies other than AC (ie, squamous cell carcinoma, large cell carcinoma). (who.int)
  • Oncogenic HPVs have also been implicated as the aetiological agents in squamous cell carcinoma of the anus, genitals and the head and neck. (cambridgemedicine.org)
  • Head and throat squamous cell carcinoma (HNSCC) may be the 6th most common malignancy worldwide and is generally impervious to curative treatment attempts. (cancerhugs.com)
  • When an NIEHS-led team disrupted a stress response pathway in mice, lung squamous cell carcinoma developed, suggesting a treatment target. (medworm.com)
  • In September 2020, BeiGene announced that the U.S. Food and Drug Administration (FDA) accepted to review a Biologics License Application (BLA) for their anti-PD-1 antibody tislelizumab to treat patients with unresectable recurrent locally advanced or metastatic Esophageal Squamous Cell Carcinoma (ESCC). (secunderabadchronicle.in)
  • Forty-eight resected specimens of oral squamous cell carcinoma were received. (jomfp.in)
  • To investigate if an association exists between diet and oral squamous cell carcinoma (OSCC) in a Brazilian population. (bvsalud.org)
  • Squamous-cell carcinoma of the oral cavity and pharynx (OSCC) is a malign neoplasm originating in the lining of the epithelium, and is considered to be the most common malign neoplasm of the oral cavity [2]. (bvsalud.org)
  • The three most common types of skin cancer, in descending order, are basal cell carcinoma, squamous cell carcinoma, and melanoma ( 1 ). (cdc.gov)
  • Squamous cell carcinoma is less common than basal cell carcinoma and can cause death, although most cases are treatable. (cdc.gov)
  • Studying the genes in a patient's tumor cells may help doctors select the best treatment for patients that have certain genetic changes. (centerwatch.com)
  • 1% of tumor cells showed any membranous staining. (esmo.org)
  • Large tumor cells with pleomorphic and hyperchromatic nuclei and scanty cytoplasm showing occasional rosette-like structures (H&E 200x). (fortunejournals.com)
  • Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsd.edu)
  • Rucaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. (ucsd.edu)
  • Histologic examination of the resected specimen disclosed obvious differentiation toward hepatocytes in tumor cells and scanty atypia in nuclei. (fujita-hu.ac.jp)
  • RATIONALE: Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. (clinicaltrials.gov)
  • Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. (clinicaltrials.gov)
  • Giving vaccine therapy together with chemotherapy and radiation therapy after surgery may kill any remaining tumor cells. (clinicaltrials.gov)
  • KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (businesswire.com)
  • KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (businesswire.com)
  • The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm, and exhibited intense mitosis 51/10 HPF. (scirp.org)
  • Based on the endometrial cytological findings (suggestive of high grade neuroendocrine carcinoma) showing that there were rosette-like and cord-like structures consisting of small rounded tumor cells with oval nuclei and scanty cytoplasm, radical hysterectomy was performed. (scirp.org)
  • This novel therapy bypasses traditional routes of treatment, which are directed against tumor cells. (roche.com)
  • Immunotherapy works by indirectly stimulating the immune system to eliminate tumor cells through negative regulators of T-cell function, such as immune checkpoint inhibitors. (roche.com)
  • These dyes are molecules that latch only onto tumor cells, fluoresce, and show surgeons the entire tumor, including any of its elusive and meandering finger-like projections that may otherwise escape resection. (embs.org)
  • Ever since Hadjipanayis first saw 5-ALA lighting up tumor cells in vibrant red, he was hooked. (embs.org)
  • 5-ALA is an orally administered compound that makes its way into the blood, crosses the blood-brain barrier, and selectively accumulates in brain tumor cells within about three hours. (embs.org)
  • Once there, it exploits metabolic differences in the tumor cells and gives off a fluorescent byproduct. (embs.org)
  • In breast invasive carcinoma (BRCA) and liver hepatocellular carcinoma (LIHC), high YIF1B expression correlated with a poor disease-free interval (DFI), indicating a role in malignancy progression. (silverchair.com)
  • High recurrence rate was a major factor for the poor postoperative prognosis of hepatocellular carcinoma (HCC) patients. (biomedcentral.com)
  • Summary This latest Pharmaceutical and Healthcare disease pipeline guide Basal Cell Carcinoma (Basal Cell Epithelioma) - Drugs In Development, 2022, provides an overview of the Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) pipeline landscape. (yahoo.com)
  • Pharmaceutical and Healthcare latest pipeline guide Basal Cell Carcinoma (Basal Cell Epithelioma) - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. (yahoo.com)
  • policies/position-papers, consulté en août 2022). (who.int)
  • 2017 (www.who.int/publications/m/item/guidance-for-the-de- (www.who.int/publications/m/item/guidance-for-the-development- velopment-of-evidence-based-vaccine-related-recommenda- of-evidence-based-vaccine-related-recommendations, consulté en tions, accessed August 2022). (who.int)
  • process, consulté en août 2022). (who.int)
  • Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis - Phytother Res 2022 Sep 9 - 'Taken together, our study provided novel insight into the anticancer effects of Resv and revealed that targeting the SIRT3/AMPK/autophagy pathway can serve as a new therapeutic target against breast cancer' - See resveratrol products at Amazon.com . (qualitycounts.com)
  • Revision and molecular examination of the metastasis and lung specimen revealed pulmonary mixed large cell neuroendocrine carcinoma with ALK-rearrangement. (bvsalud.org)
  • In 1947, Hoffman introduced the term of pulmonary tumorlet, a term that describes a form of low-grade neuroendocrine carcinoma that is capable of metastasizing to the lymph nodes ( 3 ). (spandidos-publications.com)
  • Gould introduced the concepts regarding multidirectional differentiation of neuroendocrine cells that can evolve in mucus-producing cells, squamous cells and pulmonary carcinomas. (spandidos-publications.com)
  • Molecular subtypes of pulmonary large-cell neuroendocrine carcinoma predict chemotherapy treatment outcome. (who.int)
  • Submicroscopic changes of pulmonary alveoli were represented by focal thickening of the basement membrane, multiple foci of hyperplastic type II cell (the precondition of the alveologenic tumor), active discharge of osmiophilic lamellar bodies from the type II cell and phagocytosis of the bodies by macrophages, appearance of cholesterol crystalloids in the macrophages, degeneration of alveolar septal cells and occasional appearance of a large nucleus with swelling of the capillary endothelium. (cdc.gov)
  • TAMPA, Fla. - Merkel cell carcinoma (MCC) is a rare, aggressive skin tumor that is diagnosed in approximately 2,000 people each year in the United States. (moffitt.org)
  • Additionally, DNA and proteins from the virus Merkel cell polyomavirus (MCPyV) are present in many patients with MCC, and it is now accepted that MCPyV plays an important role in MCC development in some cases. (moffitt.org)
  • According to Andrew Brohl, MD, assistant member of Moffitt's Cutaneous Oncology Department, "This study represents the largest description of the genomic landscape of Merkel cell carcinoma. (moffitt.org)
  • Merkel cell carcinoma is a very rare disease in which malignant (cancer) cells form in the skin. (cancer.gov)
  • Sun exposure and having a weak immune system can affect the risk of Merkel cell carcinoma. (cancer.gov)
  • Merkel cell carcinoma usually appears as a single painless lump on sun-exposed skin. (cancer.gov)
  • Tests and procedures that examine the skin are used to diagnose Merkel cell carcinoma. (cancer.gov)
  • Merkel cells are found in the top layer of the skin. (cancer.gov)
  • Merkel cell carcinoma , also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when Merkel cells grow out of control. (cancer.gov)
  • Merkel cell carcinoma starts most often in areas of skin exposed to the sun, especially the head and neck, as well as the arms, legs, and trunk . (cancer.gov)
  • Merkel cells are in the layer of basal cells at the deepest part of the epidermis and are connected to nerves. (cancer.gov)
  • Merkel cell carcinoma tends to grow quickly and to metastasize (spread) at an early stage . (cancer.gov)
  • Merkel cell carcinoma is the second most common cause of skin cancer death after melanoma . (cancer.gov)
  • This and other changes in the skin may be caused by Merkel cell carcinoma or by other conditions . (cancer.gov)
  • After Merkel cell carcinoma has been diagnosed, tests are done to find out if cancer cells have spread to other parts of the body. (cancer.gov)
  • Merkel cell carcinoma can recur (come back) after it has been treated. (cancer.gov)
  • Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma without a known dysplastic precursor. (nature.com)
  • The shift to neuroendocrine phenotype is associated with loss of Rb protein expression, decrease in global H3K27Me3, and increased expression of Merkel cell genes such as SOX2 . (nature.com)
  • The biology and treatment of Merkel cell carcinoma: current understanding and research priorities. (nature.com)
  • The distinctive mutational spectra of polyomavirus-negative merkel cell carcinoma. (nature.com)
  • UV-associated mutations underlie the etiology of MCV-negative merkel cell carcinomas. (nature.com)
  • Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response. (nature.com)
  • Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. (nature.com)
  • Merkel cell polyomavirus small T antigen initiates merkel cell carcinoma-like tumor development in mice. (nature.com)
  • Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. (nature.com)
  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer, which primarily afflicts Caucasian and elderly patients. (uw.edu)
  • We used comprehensive serodiagnostic methods (IgM, IgG, and IgG avidity) and PCR to study Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus infections in children observed from infancy to adolescence. (cdc.gov)
  • Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma, which is an uncommon aggressive skin cancer, and trichodysplasia spinulosa-associated polyomavirus (TSPyV) is associated with trichodysplasia spinulosa, which is a rare skin disorder ( 1 - 3 ). (cdc.gov)
  • Histological examination identified metastasis of large cell neuroendocrine carcinoma . (bvsalud.org)
  • Also known as bronchogenic cancers or bronchogenic carcinomas, lung cancer have got the tendency to grow and further spread to other organs through the process known as metastasis. (lamedtrip.com)
  • A significant association between telomerase-positive infiltrating breast carcinomas and lymphovascular invasion, a fundamental step in breast malignancy metastasis and a predictor of survival, has also been observed, making telomerase a useful prognostic marker [17]. (asiatox.org)
  • KEYTRUDA plus LENVIMA is now approved by the European Commission for two different types of cancer: for advanced or recurrent endometrial carcinoma in adults who have disease progression on or following prior treatment with a platinum-containing therapy in any setting and who are not candidates for curative surgery or radiation and for the first-line treatment of adult patients with advanced renal cell carcinoma. (merck.com)
  • Substudy 03A is part of a larger research study that is testing experimental treatments for renal cell carcinoma (RCC). (clinicaltrials.gov)
  • The goal of substudy 03A is to evaluate the safety and efficacy of experimental combinations of investigational agents in participants with advanced first line (1L) clear cell renal cell carcinoma (ccRCC). (clinicaltrials.gov)
  • Sutent has an average rating of 7.6 out of 10 from a total of 26 ratings for the treatment of Renal Cell Carcinoma. (drugs.com)
  • Compare all 44 medications used in the treatment of Renal Cell Carcinoma . (drugs.com)
  • Finally there is a rare but life threatening syndrome called hereditary leiomyomatosis and renal cell carcinoma. (bellaonline.com)
  • This photograph reveals gross pathologic changes in a bisected kidney tissue specimen, in a case of a large, renal cell carcinoma (RCC). (cdc.gov)
  • The preferred method of imaging renal cell carcinomas is dedicated renal computed tomography (CT). (medscape.com)
  • To assess clinicopathological features of patients with keratocystic odontogenic tumor (KCOT) associated with nevoid basal cell carcinoma syndrome (NBCCS) in a single Brazilian institution. (bvsalud.org)
  • Nevoid basal cell carcinoma syndrome (NBCCS) was first described in 1960 by Gorlin and Goltz and was characterized by multiple basal cell carcinomas (BCC), odontogenic keratocysts (OKC) and bifid ribs 1 . (bvsalud.org)
  • Gonzalez-Bosquet E, Gaba L, Saco MA, Gil-Ibañez B, Fuster P, Glickman A, Torne A. Metastatic Large Cell Neuroendocrine Carcinoma of the Endometrium: A Case Report and Literature Review. (fortunejournals.com)
  • Imaging studies are useful to rule out metastatic disease for patients with large vulvar lesions and/or palpable inguinal lymph nodes. (medscape.com)
  • KEYNOTE-361 (ClinicalTrials.gov, NCT02853305 ) is a randomized, open-label, Phase 3 trial evaluating KEYTRUDA as monotherapy and in combination with chemotherapy versus chemotherapy alone, the current standard of care, for the first-line treatment of advanced or metastatic urothelial carcinoma. (businesswire.com)
  • OBJECTIVES: I. Determine the efficacy of temozolomide in terms of complete and partial response rates in patients with metastatic non-small cell lung cancer. (knowcancer.com)
  • The overall survival findings from KEYNOTE-189 and KEYNOTE-407 changed the way patients with metastatic non-small cell lung cancer were treated and established KEYTRUDA plus chemotherapy as a foundational first-line treatment for this devastating disease," said Dr. (ft.com)
  • These results show meaningful improvements in five-year survival for patients receiving KEYTRUDA plus chemotherapy and reinforce the important role of these KEYTRUDA-based regimens as standards of care for metastatic non-small cell lung cancer. (ft.com)
  • Basal cell carcinoma (BCC) is the most prevalent type of skin cancer in the white population, and it is the most common malignancy overall in humans. (bioline.org.br)
  • The pivotal study evaluated the combination of KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, versus chemotherapy (treatment of physician's choice of doxorubicin or paclitaxel) for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting. (merck.com)
  • While rates of endometrial carcinoma continue to rise globally, patients with advanced or recurrent disease have limited options available to them once the disease progresses following platinum-based chemotherapy," said Dr. Gregory Lubiniecki, Vice President, Oncology Clinical Research, Merck Research Laboratories. (merck.com)
  • KEYNOTE-775/Study 309 is an important Phase 3 study that supported recent approvals of KEYTRUDA plus LENVIMA for certain types of advanced endometrial carcinoma in the U.S. and other countries around the world, where it became the first immunotherapy and tyrosine kinase inhibitor combination approved for these patients. (merck.com)
  • Based on the results from the Phase 3 KEYNOTE-775/Study 309 trial, KEYTRUDA plus LENVIMA has been approved in the U.S. for patients with advanced endometrial carcinoma that is not microsatellite instability-high or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (merck.com)
  • KEYTRUDA plus LENVIMA is also approved in the European Union and Japan for certain patients with advanced or recurrent endometrial carcinoma regardless of mismatch repair status. (merck.com)
  • KEYNOTE-775/Study 309 ( ClinicalTrials.gov, NCT03517449 ) is a Phase 3, multicenter, open-label, randomized, active-controlled study conducted in 827 patients with advanced endometrial carcinoma who had been previously treated with at least one prior platinum-based chemotherapy regimen in any setting, including in the neoadjuvant and adjuvant settings. (merck.com)
  • Studies of large cell endometrial neuroendocrine carcinoma (LCNEC) are even less common, with only 16 cases documented [1,5,6]. (fortunejournals.com)
  • This marks the first combination of an immunotherapy with a tyrosine kinase inhibitor approved in Europe for these patients with advanced or recurrent endometrial carcinoma. (merck.com)
  • The safety of KEYTRUDA in combination with LENVIMA was evaluated in 530 patients with advanced endometrial carcinoma. (merck.com)
  • An endometrial aspiration is performed by passing a very thin instrument through the cervical opening into the uterus and suctioning a small amount of fluid with cells from the lining of the uterus for evaluation. (creighton.edu)
  • Histopathological and immunohistochemical examinations on the operated specimens revealed primary high grade neuroendocrine carcinoma of the endometrium. (scirp.org)
  • However, Moffitt Cancer Center researchers have developed the largest descriptive genomic analysis of MCC patients to date, in collaboration with Foundation Medicine and the Dana Farber Cancer Institute. (moffitt.org)
  • Prior to the Moffitt study, the largest analysis of MCC patients included fewer than 50 patients. (moffitt.org)
  • This ALCHEMIST trial studies genetic testing in screening patients with stage IB-IIIA non-small cell lung cancer that has been or will be removed by surgery. (centerwatch.com)
  • To study the clinical significance of circulating tumor DNA within the plasma cell-free DNA (cfDNA) from early stage lung cancer patients. (centerwatch.com)
  • STEP 1 (SCREENING): Patients undergo collection of blood and tissue samples for EGFR, ALK, and programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1)/cytotoxic t-lymphocyte-associated protein 4 (CTLA-4) testing via direct sequencing, fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). (centerwatch.com)
  • Patients presenting with basal cell carcinoma (BCC) often report a slowly enlarging lesion that does not heal and that bleeds when traumatized. (medscape.com)
  • This randomized phase II trial studies how well chemotherapy and radiation therapy given with or without metformin hydrochloride works in treating patients with stage III non-small cell lung cancer. (ucsd.edu)
  • This phase II Lung-MAP trial studies how well rucaparib works in treating patients with genomic loss of heterozygosity (LOH) high and/or deleterious BRCA1/2 mutation stage IV non-small cell lung cancer or that has come back. (ucsd.edu)
  • This randomized phase III trial studies carboplatin and paclitaxel to compare how well they work with or without bevacizumab and/or cetuximab in treating patients with stage IV or non-small cell lung cancer that has returned after a period of improvement (recurrent). (ucsd.edu)
  • It is not yet known whether giving carboplatin and paclitaxel are more effective with or without bevacizumab and/or cetuximab in treating patients with non-small cell lung cancer. (ucsd.edu)
  • Correlate specific in vivo parameters of immune response (post-vaccination delayed-type hypersensitivity reactions to autologous tumor, mesothelin-specific T-cell response, and the degree of local eosinophil, macrophage, and T-cell infiltration at the vaccine site) with clinical responses in patients treated with this regimen. (clinicaltrials.gov)
  • Patients with non-small cell lung cancer require a complete staging work-up to evaluate the extent of disease because stage plays a major role in determining the choice of treatment. (medscape.com)
  • FRIDAY, Feb. 3, 2023 -- Almost half of patients with non-small cell lung cancer (NSCLC) are not being imaged in accordance with national guidelines prior to subsequent radiation therapy, according to a study recently published in the Journal of. (medworm.com)
  • Materials and Methods: The standardized uptake values and the volumetric parameters (metabolic tumor value and total lesion glycolysis) were determined by 18F-FDG-PET/CT to identify RD in 39 patients before and after nCRT for esophageal carcinoma. (bvsalud.org)
  • Continuing with analysis of TCGA samples, I then analyze a large pan-cancer set of patients with both tumor and adjacent normal tissue samples profiled. (escholarship.org)
  • Treating the cancer cells with Ganoderma extract before administering chemotherapy drugs made the cancer more sensitive to treatment, which could potentially lower the effective dose of chemotherapy enough for patients to tolerate it, Dr. Sadava says. (dailyramblingsofaprofessionalnetworker.com)
  • From a large data repository, we identified and retrospectively evaluated 95 MCC patients that were chronically immunosuppressed at the time of diagnosis and were treated with curative intent between 1988 and 2016. (uw.edu)
  • Objectives: To explore the relationship between peripheral blood inflammation parameters and overall survival (OS) and progression-free survival (PFS) of early-stage non-small cell lung cancer patients who underwent stereotactic body radiotherapy (SBRT). (bvsalud.org)
  • Currently, development of vulvar carcinoma in situ in young women is suggested to correlate to human papillomavirus (HPV) infection. (medscape.com)
  • Estimates indicate that women who smoke cigarettes have a 4- to 5-fold increase in the incidence of carcinoma in situ of the vulva and a 20% increase in vulvar carcinoma. (medscape.com)
  • The incidence of vulvar carcinoma in situ and vulvar carcinoma is higher in women with multiple sexual partners and in women with a history of HPV infection. (medscape.com)
  • For women who report a history of genital warts or HPV-related disease, the relative risk for carcinoma in situ is 18.5 and for invasive cancer is 14.5. (medscape.com)
  • Large cell carcinoma of the lung is kind of a catch-all diagnosis for large cell lung cancers that can't be classified into the other specific subgroups. (healthline.com)
  • Non-small cell carcinomas, like LCLC, are the most common form of lung cancer, making up 80 to 85 percent of all lung cancers. (healthline.com)
  • They also tend to grow more quickly and spread faster than other forms of non-small cell lung cancers. (healthline.com)
  • LCLC makes up 10 to 15 percent of all non-small cell lung cancers. (healthline.com)
  • Ideally, non-small cell lung cancers are diagnosed in the early stages, when there are more and better treatment options. (healthline.com)
  • Small cell lung cancer (SCLC) accounts for around 10% to 15% of all lung cancers and very rarely develops in someone who has not smoked. (cancer.net)
  • Lung cancer has been categorized into two major histological subtypes as non-small cell lung cancers (NSCLCs) and small cell lung cancer (SCLC). (roche.com)
  • Tessa will use the proceeds to continue the advancement of its clinical pipeline and to bring new therapies into clinical trials, broadening the range of cancers that can be treated with the company's Virus Specific T cell (VST) platform. (edbi.com)
  • Analysis of these large in multiple cancerS - a mendelian through the study of genetic susceptibility genome-wide studies also includes a randomization approach variants of various cancer sites, and also Mendelian randomization approach that patterns of genetic mutations that are aims to understand how lifestyle factors Elevated body mass index (BMI) and observed in tumours. (who.int)
  • Non-small cell lung cancer accounts for approximately 85% of all lung cancers. (medscape.com)
  • Non-small cell lung cancer (NSCLC) - Around 85% of all lung cancers comes under this category. (lamedtrip.com)
  • They range from low- and intermediate-grade typical and atypical carcinoma, to the highly malignant large cell neuroendocrine lung carcinoma and small cell carcinoma, with marked differences in incidences and prognosis. (mdpi.com)
  • Lung cancer is a malignant lung tumor characterized by uncontrolled cell growth in the tissues of the lung. (drtathed.com)
  • Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. (curehunter.com)
  • analyzing high-risk oral precancerous and cancerous lesions using multi-omics and single-cell omics technologies to clarify the process of malignant transformation from precancer to cancer. (cgu.edu.tw)
  • In the future, larger studies will be required to elucidate the biological behavior of the malignant transformation of endometriotic lesions, the histological pattern of disease progression and the genetic alterations which associates the two diseases. (vejthani.com)
  • This is a case report of a patient with a high-grade large cell neuroendocrine carcinoma in the ascending colon with an overlying tubular adenoma discovered during routine colonoscopic screening in absence of clinical symptoms. (wjgnet.com)
  • Large cell lung carcinoma (LCLC) is one form of non-small cell lung cancer that tends to grow more quickly and spread more aggressively than some other forms. (healthline.com)
  • This type of lung cancer is named so because of its large, abnormal-looking cells. (healthline.com)
  • This type of non-small cell lung cancer usually begins in the middle structures of the lung, like the bronchi . (healthline.com)
  • However, since many symptoms are common to other conditions, a diagnosis isn't made until the later stages in many cases of non-small cell lung cancer. (healthline.com)
  • I. To centrally test resected non-small cell lung cancer (NSCLC) for genetic mutations to facilitate accrual to randomized adjuvant studies. (centerwatch.com)
  • It usually grows and spreads more slowly than small cell lung cancer . (medlineplus.gov)
  • Smoking causes most cases (around 90%) of non-small cell lung cancer. (medlineplus.gov)
  • Research shows that smoking marijuana may help cancer cells grow. (medlineplus.gov)
  • Chemotherapy uses drugs to kill cancer cells and stop new cells from growing. (medlineplus.gov)
  • Targeted therapy uses drugs to zero in on specific targets (molecules) in or on cancer cells. (medlineplus.gov)
  • These targets play a role in how cancer cells grow and survive. (medlineplus.gov)
  • If a cell lives but repair is incomplete, lung cancer can develop (NRCC 1999). (cdc.gov)
  • Immunotherapy is type of cancer treatment that works by boosting or activating your immune system, so it recognizes and kills cancer cells. (cancer.net)
  • Researchers are investigating 4 main kinds of immunotherapies for lung cancer: checkpoint inhibitors, monoclonal antibodies, therapeutic vaccines, and adoptive cell therapy. (cancer.net)
  • Fred Taussig collected a large series of vulvar cancer cases from 1911-1940. (medscape.com)
  • It is not yet known whether chemotherapy and radiation therapy is more effective when given with or without metformin hydrochloride in treating stage III non-small cell lung cancer. (ucsd.edu)
  • Cetuximab may also stop cancer cells from growing by binding and interfering with a protein on the surface of the tumor cell that is needed for tumor growth. (ucsd.edu)
  • Original diagnosis was clear cell cancer and removed right kidney. (drugs.com)
  • The removal of skin cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (cancer.gov)
  • Bladder cancer begins when cells in the urinary bladder start to grow uncontrollably. (businesswire.com)
  • As more cancer cells develop, they can form a tumor and spread to other areas of the body. (businesswire.com)
  • Urothelial carcinoma, the most common type of bladder cancer, starts in the urothelial cells that line the inside of the bladder. (businesswire.com)
  • But what exactly does that mean and where can breast cancer cells go? (clevelandclinic.org)
  • Cancer cells can travel through the bloodstream to other areas of your body. (clevelandclinic.org)
  • Cancer cells can also move through your lymphatic system to other parts of your body. (clevelandclinic.org)
  • You might also be more prone to bone breaks or fractures because of cancer cells being embedded in your bones or spinal cord. (clevelandclinic.org)
  • Meanwhile, the American Joint Committee on Cancer (AJCC) defines highly differentiated NEN as a neuroendocrine tumor (NET) and the poorly differentiated NEN as a neuroendocrine carcinoma (NEC) based on the degree of tumor cell differentiation. (biomedcentral.com)
  • Medgysey, C.D., Wolff, R.A., Putnam Jr, J.B. and Ajani, J.A. (2000) Small cell carcinoma of the esophagus: The University of Texas M.D. Anderson Cancer Center experience and literature review. (scirp.org)
  • To better understand the relationship between these distinct tumor cell populations, we evaluated 7 pairs of MCC-SCCIS for overlapping genomic alterations by cancer profiling panel. (nature.com)
  • Small Cell Lung Cancer, What Is This? (empowher.com)
  • Lung cancer generally is looked at by its pathologic appearance and we classify it into small cell lung cancer and no-small cell lung cancer. (empowher.com)
  • Describes the appearance of cancer cells under the microscope, and how differently they have become from what normal cells look like. (bccancer.bc.ca)
  • The process whereby cancer cells from the original tumour spread to other sites in the body. (bccancer.bc.ca)
  • Cellectis S.A., a clinical stage biotechnological company, develops immuno-oncology products based on gene-edited T-cells that express chimeric antigen receptors to target and eradicate cancer cells. (yahoo.com)
  • Basal cell carcinoma is a type of skin cancer which begins in the basal cells. (yahoo.com)
  • Tessa's Virus-Specific T cell (VST) technology is showing compelling results and an excellent safety profile in the treatment of cancer. (edbi.com)
  • Tessa Therapeutics is a clinical stage biopharmaceutical company with the scientific vision of revolutionizing the treatment of cancer by redirecting the body's potent anti-viral immune response to recognize and kill cancer cells. (edbi.com)
  • Tessa's lead trial for nasopharyngeal carcinoma (NPC) is the world's largest Phase III T cell immunotherapy trial for any cancer indication. (edbi.com)
  • Data for analysis of YIF1B mRNA expression were downloaded from the website portals: The Cancer Genome Atlas (TCGA), GTEx, Cancer Cell Line Encyclopedia (CCLE) and International Cancer Genome Consortium (ICGC), including clinical and mutational information. (silverchair.com)
  • There was a positive relationship between YIF1B expression and immune cell infiltration in several cancer types, and YIF1B also positively correlated with TMB, MSI, and methylation in some cancer types, linking its expression to possible evaluation of therapy response. (silverchair.com)
  • There is also limited evidence that absence of excess body fatness reduces the risk of fatal prostate cancer, breast cancer in men, and diffuse large B-cell lymphoma. (who.int)
  • Paraneoplastic syndromes are more likely to occur in small cell lung cancer than in non-small cell lung cancer. (medscape.com)
  • The lung cancer usually originates in the cells that are developed in the air passage. (lamedtrip.com)
  • Small cell lung cancer (SCLC) - The main cause of this type of lung cancer is heavy smoking. (lamedtrip.com)
  • 3 - Targeted Drug Therapy - As the name suggest, targeted drug therapy specifically targets the abnormalities formed in the cancer cells to destroy them. (lamedtrip.com)
  • Curcumol reduced the proliferation of breast cancer cells by targeting NCL/ERα36 and inactivating the PI3K/AKT pathway' - See curcumin at Amazon.com . (qualitycounts.com)
  • Resveratrol (Res) exerts inhibitory effects on breast cancer cell lines and animal models, while its efficacy against individual breast cancer cases remains unknown. (qualitycounts.com)
  • The Company has also initiated a Phase 1 trial (KURRENT-LUNG) of tipifarnib in combination with osimertinib in EGFR-mutant non-small cell lung cancer. (wjbf.com)
  • Carcinogenesis - The generation of cancer from normal cells, correctly the formation of a carcinoma from epithelial cells. (creighton.edu)
  • Telomerase inhibition as an anticancer approach The average telomere length in breast cancer cells is usually well below that of normal cells. (asiatox.org)
  • This difference in telomere length coupled with the more rapid rate of cell division in cancer cells makes the inhibition of telomerase a stylish potential breast cancer therapeutic target. (asiatox.org)
  • Since most breast cancer cells have very short telomeres, treatment with telomerase inhibitors should lead to growth arrest and cell death. (asiatox.org)
  • Telomelysin (OBP-301) is a gene-modified oncolytic adenovirus that selectively replicates in cancer cells by introducing human telomerase reverse transcriptase (hTERT) promoter. (secunderabadchronicle.in)
  • STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. (cusabio.com)
  • Interference of STAT 5b expression by siRNA targeting enhanced the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. (cusabio.com)
  • Src is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases (2). (signalchem.com)
  • In addition to increasing cell proliferation, a key role of Src in cancer seems to be the ability to promote invasion and motility, functions that might contribute to tumour progression. (signalchem.com)
  • We also use single cell omics technique to deal with the heterogeneity of cancer lesions and improve understanding of disease mechanisms. (cgu.edu.tw)
  • exploring the roles of EVs in the process of oral cancer carcinogenesis, and also finding out the membrane protein biomarkers on EVs for verifying their effectiveness in a large cohort of saliva samples. (cgu.edu.tw)
  • 2020) Ginsenoside M1 Induces Apoptosis and Inhibits the Migration of Human Oral Cancer Cells . (cgu.edu.tw)
  • Several reports support the theory that endometrioid epithelial ovarian cancer (EEOC) and Ovarian clear cell carcinoma (OCCC) arise in endometriosis. (vejthani.com)
  • To treat this cancer, doctors typically turn to chemotherapy, which attacks cancer cells throughout the body. (dailyramblingsofaprofessionalnetworker.com)
  • For the first time, Dr. Sadava and his team set out to investigate its effects on small-cell lung cancer. (dailyramblingsofaprofessionalnetworker.com)
  • The researchers took extracts of these herbs and tested them on three different types of cells: drug-sensitive small-cell lung cancer, drug-resistant small-cell lung cancer, and normal lung cells. (dailyramblingsofaprofessionalnetworker.com)
  • They discovered that Ganoderma lucidum, as well as eight other Ganoderma species killed lung cancer cells. (dailyramblingsofaprofessionalnetworker.com)
  • Cancer cells responded to the herb much in the same way as they would react to chemotherapy drugs. (dailyramblingsofaprofessionalnetworker.com)
  • Yet unlike chemotherapy drugs, which can also be toxic to healthy cells, herbal extracts were more deadly to cancer cells than to normal cells, indicating that they have some ability to specifically target cancer. (dailyramblingsofaprofessionalnetworker.com)
  • Ganoderma won't replace current therapies for small-cell lung cancer, but it can work in conjunction with chemotherapy to increase its effectiveness. (dailyramblingsofaprofessionalnetworker.com)
  • The so-called "nutritional transition" caused a change in "traditional" eating patterns based on the consumption of grain and cereals, which has been gradually superseded by an eating pattern that has large quantities of foods of animal origin, fats, sugars, processed foods and relatively small amounts of complex carbohydrates and fiber, eating habits deemed to be potentially favorable to the development of oropharyngeal cancer [7]. (bvsalud.org)
  • Basal cell carcinoma alone is thought to be more common than any other cancer, but central cancer registries* (CCRs) do not collect data on basal cell carcinoma, so incidence is unknown. (cdc.gov)
  • Dans notre étude, nous avons évalué la surexpression de l'HER2 par technique immunohistochimique sur 30 cas, en utilisant les mêmes critères d'interprétation que pour le cancer du sein. (bvsalud.org)
  • Oligometastatic non-small-cell lung cancer (NSCLC) is potentially curable. (bvsalud.org)
  • Adjuvant Treatments for Surgically Resected Non-Small Cell Lung Cancer Harboring EGFR Mutations: A Review. (cdc.gov)
  • The use of adjuvant chemotherapy for stage IB-IIIA resected non-small cell lung cancer (NSCLC) has limited benefit for improving cure rates. (cdc.gov)
  • PSA levels have been used in screening large populations of men for prostate cancer and have been shown to be useful. (medscape.com)
  • A tumor of undifferentiated (anaplastic) cells of large size. (bvsalud.org)
  • The large amount of genetic information accumulated in the post-genomic era needs to be transformed into knowledge 1 . (nature.com)
  • The reappearance of anti-EA antibodies signals viral reactivation and provides a clue to the possible role of this virus in diseases such as nasopharyngeal carcinoma and Burkitt's lymphoma. (justia.com)
  • Esophageal neuroendocrine carcinomas are rare, aggressive and have a poor prognosis. (scirp.org)
  • However, if lymphoma or larger carcinoid was identified, chemotherapy or more extensive surgery will be required. (hindawi.com)
  • Chemotherapy can have severe side effects though, because it attacks healthy cells as well as cancerous ones. (dailyramblingsofaprofessionalnetworker.com)
  • In multivariable analysis previous hospital admission or emergency department visit, prior chemotherapy or radiation therapy, stage 4 disease at diagnosis, lower hemoglobin, higher white blood cell count, and higher symptom burden were associated with higher risk of EM. (cdc.gov)
  • The aim of the study was to evaluate the expression of HER 2 in urothelial carcinoma of the bladder in 30 cases selected from a series of 361 cases collected at the anatomy pathology department of the CHU of Batna and to compare our results with data from the literature. (bvsalud.org)
  • The treatment of mixed large cell neuroendocrine carcinoma is less studied due to its low incidence . (bvsalud.org)
  • Unfortunately, the incidence of preinvasive disease of the vulva has almost doubled over the past decade, and this may translate into a marked increase in the incidence of invasive vulvar carcinoma in the future. (medscape.com)
  • The incidence of vulvar carcinoma has a bimodal peak. (medscape.com)
  • Although differention between liver cell adenoma and well-differentiate dhepatocellular carcinoma(Edmondson grade I) is deemed difficult, it is our opinion that the diagnosis of liver cell adenoma can be made by following characteristics: 1) incidence in young adult 2) no underlying liver disease 3) large tumor in the majority of cases 4) histologic findings of monotonous growth and scanty atypia. (fujita-hu.ac.jp)
  • In the malarial belt of Africa, EBV is a contributory factor in the development of Burkitt's lymphoma and in South-East Asia, the virus is linked to the high incidence of undifferentiated nasopharyngeal carcinomas. (justia.com)
  • Because of improvements in diagnostic tests such as CT and MRI, the incidence of RCC has increased, with the most common type of RCC being clear cell carcinoma. (medscape.com)
  • High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. (cusabio.com)
  • Basal cell carcinoma occurs mostly on the face, head (scalp included), neck, and hands. (medscape.com)
  • Basal cell carcinoma of the right lower lid. (medscape.com)
  • Biopsy-proven basal cell carcinoma of the upper lid margin. (medscape.com)
  • Medial canthal/lower lid basal cell. (medscape.com)
  • I have a basal cell carcinoma on my lower lip. (earthclinic.com)
  • please tell us where you got this cream for basal cell carcinoma for $34.95 in New Jersey. (earthclinic.com)
  • The 70 year old gentleman with the large facial basal cell carcinoma should have it treated by a radiation oncologist (NOT a medical oncologist. (earthclinic.com)
  • To our knowledge, this letter presents the first case that shows the association between erythema ab igne and basal cell carcinoma. (cdlib.org)
  • The histological examination was compatible with basal cell carcinoma. (bioline.org.br)
  • Rao GR, Amareswar A, Kumar YH, Prasad TS, Rao NR. Pigmented basal cell carcinoma of the scrotum: An unusual site. (bioline.org.br)
  • The Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) pipeline guide also reviews of key players involved in therapeutic development for Basal Cell Carcinoma (Basal Cell Epithelioma) and features dormant and discontinued projects. (yahoo.com)
  • Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. (yahoo.com)
  • The pipeline guide provides a snapshot of the global therapeutic landscape of Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology). (yahoo.com)
  • The pipeline guide reviews pipeline therapeutics for Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) by companies and universities/research institutes based on information derived from company and industry-specific sources. (yahoo.com)
  • The pipeline guide reviews key companies involved in Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) therapeutics and enlists all their major and minor projects. (yahoo.com)
  • The pipeline guide evaluates Basal Cell Carcinoma (Basal Cell Epithelioma) (Oncology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. (yahoo.com)
  • The mass which appeared like a cabbage head was biopsied and diagnosed as 'looking like a basal-cell carcinoma' (Dr. Penha provides x-ray pictures corresponding to the diagnosis). (healingcancernaturally.com)
  • Basal Cell Carcinoma (BCC) and OKC are the most common incident manifestations of the syndrome 3 . (bvsalud.org)
  • The "early antigen complex" consists of the "early antigen-diffuse" (EA-D) and the "early antigen-restricted" (EA-R) antigens, based on their distribution in immunofluorescence assays in the cytoplasm plus nucleus (i.e. diffuse distribution) or in the cytoplasm only (i.e. restricted) and based on their staining appearance in methanol-fixed cells. (justia.com)
  • Well demarcated nest and island of large atypical cells with organoid pattern, infiltrating uterine corpus (H&E 40x). (fortunejournals.com)
  • Hiyama observed that all atypical or intermediate cases with detectable telomerase activity in the FNAs were found to be carcinomas after surgery [14]. (asiatox.org)
  • Tetzlaff, M. T. & Harms, P. W. Danger is only skin deep: aggressive epidermal carcinomas. (nature.com)
  • Approximately only 90 cases of small cell neuroendocrine carcinoma of the endometrium have been reported [3,4]. (fortunejournals.com)
  • Campo, E., Brunier, M.N. and Merino, M.J. (1992) Small Cell Carcinoma of the Endometrium with Associated Ocular Paraneoplastic Syndrome. (scirp.org)
  • 5877 - TCR beta chain convergence defines the tumor infiltrating T cell repertoire of melanoma and non-small cell lung carcinoma. (esmo.org)
  • Observation identified breast asymmetry with a much larger left breast that presented a tender, firm nodule occupying the whole outer upper quadrant, approximately 7cm in diameter and attached to underlying tissues. (pediatriconcall.com)
  • However, we are unaware of any comprehensive large-scale studies that analyze population breast sizes that provide design guidelines for such precision medicine machines. (uw.edu)
  • Histology of biopsy specimens indicated a neuroendocrine carcinoma. (scirp.org)
  • In this article, you'll learn about the differences between small and large cell carcinomas in the lung, how LCLC is diagnosed and treated, and what to expect if you receive this diagnosis. (healthline.com)
  • These findings led to the diagnosis of neuroendocrine carcinoma of small cell type. (scirp.org)
  • There is a huge difference between small lesions which can be treated topically and large cells that can spread to vital organs. (earthclinic.com)
  • Huncharek, M. and Muscat, J. (1995) Small cell carcinoma of the esophagus. (scirp.org)
  • Our findings suggest an epidermal origin of MCC in this setting, and to our knowledge provide the first molecular evidence that intraepithelial squamous dysplasia may represent a direct precursor for small cell carcinoma. (nature.com)
  • Crowder, S. and Tuller, E. (2007) Small Cell Carcinoma of the Female Genital Tract. (scirp.org)
  • Introduction Black soldier flies are small, harmless insects that have the potential to provide promising solutions to two of modern agriculture's growing problems: the high cost of animal feed and the disposal of large amounts of animal waste. (seo-tips.tech)
  • Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. (dailyramblingsofaprofessionalnetworker.com)
  • Another mechanism entails excessive growth along with a suppression of normal cell death inciting somatic mutations that lead to tumor development. (bellaonline.com)
  • Furthermore, this study shows the largest clinical data about KCOT associated with NBCCS ever compiled in the Brazilian population. (bvsalud.org)
  • Les résultats ont été évalués en utilisant le score d'interprétation de l'American Society of Clinical Oncology (l'ASCO), basé sur le pourcentage de cellules marquées, et l'intensité du marquage dans la perspective d'un traitement par le Trastuzumab (Herceptine). (bvsalud.org)
  • Results were assessed using the American Society of Clinical Oncology (ASCO) Interpretive Score, based on the percentage of cells labeled, and the intensity of labeling in the perspective of Trastuzumab treatment. (bvsalud.org)
  • abstract = "A 33-year-old female patient underwent extended right lobectomy for a large tumor in the liver. (fujita-hu.ac.jp)
  • Resection of the primary lesion is the treatment of choice for vulvar carcinoma. (medscape.com)
  • I've just had a large infiltrative lesion from my waistline treated with radiation as well. (earthclinic.com)
  • Treatment with telomerase inhibitors may not have the toxicity found with other chemotherapeutic brokers since telomerase is usually absent in most somatic cells (Fig. (asiatox.org)
  • This research will test the combination of two new drugs, called ibrutinib and ABT199, taken together in the treatment of Mantle Cell Lymphoma. (clinicaltrials.gov)
  • Other studies have indicated the potential for these drugs to be used in the treatment of participants with Mantle Cell Lymphoma. (clinicaltrials.gov)
  • The pathologic evaluation revealed a large number of cells with large, oval, deeply basophillic nuclei and scanty cytoplasm. (bioline.org.br)