A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Tumors or cancer of the LUNG.
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A malignant epithelial tumor with a glandular organization.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A cell line derived from cultured tumor cells.
Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN. It is characterized by solitary nodules or ulcerated tumors.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Tumors or cancer of the SKIN.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Clinically benign, histologically malignant, recurrent cutaneous T-cell lymphoproliferative disorder characterized by an infiltration of large atypical cells surrounded by inflammatory cells. The atypical cells resemble REED-STERNBERG CELLS of HODGKIN DISEASE or the malignant cells of CUTANEOUS T-CELL LYMPHOMA. In some cases, lymphomatoid papulosis progresses to lymphomatous conditions including MYCOSIS FUNGOIDES; HODGKIN DISEASE; CUTANEOUS T-CELL LYMPHOMA; or ANAPLASTIC LARGE-CELL LYMPHOMA.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the NASOPHARYNX.
DNA present in neoplastic tissue.
Tumors or cancer of the THYROID GLAND.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the human BREAST.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
A general term for various neoplastic diseases of the lymphoid tissue.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Tumors or cancer of the BRONCHI.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Tumors or cancer of the STOMACH.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.
Antibodies produced by a single clone of cells.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Tumors or cancer of the URINARY BLADDER.
Neoplasms composed of more than one type of neoplastic tissue.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
RNA present in neoplastic tissue.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Tumors or cancer of the UTERINE CERVIX.
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Loss of structural differentiation and useful function of neoplastic cells.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Elements of limited time intervals, contributing to particular results or situations.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Transplantation between animals of different species.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Tumors or cancer of the gallbladder.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A DNA-binding protein that represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Established cell cultures that have the potential to propagate indefinitely.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Tumors or cancer of the SALIVARY GLANDS.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Tumors or cancer of the NOSE.
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
Biochemical identification of mutational changes in a nucleotide sequence.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The quantity of volume or surface area of CELLS.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Mapping of the KARYOTYPE of a cell.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
The degree of replication of the chromosome set in the karyotype.
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An expression of the number of mitoses found in a stated number of cells.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
An antineoplastic agent derived from BLEOMYCIN.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.
Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.

Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. (1/382)

The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in various tumor cell lines including human non-small cell lung carcinoma (NSCLC) cells, which are resistant to the natural all-trans retinoic acid and to many synthetic receptor-selective retinoids. Although the mechanism of this effect was not elucidated, it was found to be independent of nuclear retinoid receptors. In the present study, we analysed the mechanisms by which CD437 induces apoptosis in two human NSCLC cell lines: H460 with wild-type p53 and H1792 with mutant p53. Both cell lines underwent apoptosis after exposure to CD437, although the cell line with wild-type p53 (H460) was more sensitive to the induction of apoptosis. CD437 increased the activity of caspase in both cell lines, however, the effect was much more pronounced in the H460 cells. The caspase inhibitors (Z-DEVD-FMK and Z-VAD-FMK) suppressed CD437-induced CPP32-like caspase activation and apoptosis in both cell lines. CD437 induced the expression of the p53 gene and its target genes, p21, Bax, and Killer/DR5, only in the H460 cells. These results suggest that CD437-induced apoptosis is more extensive in NSCLC cells that express wild-type p53, possibly due to the involvement of the p53 regulated genes Killer/DR5, and Bax although CD437 can also induce apoptosis by means of a p53-independent mechanism. Both pathways of CD437-induced apoptosis appear to involve activation of CPP32-like caspase.  (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (2/382)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important.  (+info)

Lung cancer incidence rates by histologic type in high- and low-risk areas; a population-based study in Osaka, Okinawa, and Saku Nagano, Japan. (3/382)

We investigated lung cancer incidence by histologic type using the data from population-based cancer registries in high-risk (Osaka and Okinawa) and low-risk (Saku Nagano) areas. Since the proportion of cases with histologic types identified was not sufficiently high, sex- and age-specific incidence rates by histologic type were estimated assuming that the distribution of histologic types was the same across the same sex and age groups regardless of reporting status. Compared to Saku in Nagano Prefecture, the cumulative risk of lung cancer incidence rates in Osaka and Okinawa were 1.3 and 1.5 times higher for males and 1.3 and 1.2 times higher for females, respectively. When divided by histologic type, male adenocarcinoma and small cell carcinoma were 1.6-2.1 times higher in Osaka and Okinawa, while squamous cell carcinoma was 1.6 times higher only in Okinawa compared to Saku Nagano. In females, squamous cell carcinoma and small cell carcinoma were 2.5-3.3 times higher in Osaka and Okinawa compared to Saku Nagano, while adenocarcinoma was almost equal in the 3 areas. These results indicate that the pattern of incidence of lung cancer by histologic type may differ between high- and low- risk areas.  (+info)

Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. (4/382)

Poly(ADP-ribose) polymerase (PADPRP) is a nuclear DNA-binding enzyme that can modulate chromatin structure close to DNA replication, recombination and repair regions. Two-allele polymorphism on the PADPRP chromosome 13 pseudogene has been studied in several ethnic subpopulations, and the association of each allele with different types of cancer has been investigated. To study the frequency of the allele in the context of lung cancer, we performed a PCR assay for the PADPRP polymorphism in 288 lung cancer patients and 292 matched controls and examined the frequency of the alleles in different ethnic groups. Our results showed that the allele distribution was significantly different among members of different ethnic groups. Specifically, the A allele was dominant in Mexican-American and Caucasian groups but not in the African-American group. The frequencies of the B allele in Mexican-American, Caucasian and African-American controls were 0.184, 0.218 and 0.606, respectively, with the Caucasian cases and controls showing an almost identical lower B allele frequency (0.199 in cases versus 0.218 in controls), and the African-American cases and controls showing an almost identical but considerably higher frequency (0.578 in cases versus 0. 606 in controls). In contrast, the Mexican-American cases and controls exhibited a considerable difference in the B allele frequency (0.306 in cases versus 0.184 in controls). When we combined subjects with the AB or BB genotype into a susceptible genotype group and compared them with the AA group using univariate analysis, the susceptible genotype was not shown to be associated with a risk of lung cancer in either the Caucasian or African-American subpopulation but was significantly associated with an increased risk (2.29-fold) of lung cancer in the Mexican-American group. When lung cancer was categorized by histologic type, no elevated risk was noted for squamous cell carcinoma in any ethnicity. However, in Mexican-Americans, susceptible genotypes were associated with significantly increased risks of adenocarcinoma (3. 21-fold) and large cell carcinoma (10.79). Our study and others have demonstrated that the PADPRP polymorphism may modify an individual's susceptibility to certain cancers. Assessment of the interaction between genetic constitution and environmental exposure might expand our understanding of carcinogenesis and enhance our ability to evaluate the populational cancer risk.  (+info)

p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer. (5/382)

The oncogene product epidermal growth factor receptor (EGF-R), the tumour suppressor gene product p53 and anti-p53 antibodies are detectable in the serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure and after exposure to polycyclic aromatic hydrocarbons or vinylchloride. In the first step, this study investigated the possible diagnostic value of serum EGF-R, p53-protein and anti-p53 antibodies, measured by an enzyme-linked immunosorbent assay, in lung tumour patients. In addition to being investigated on a molecular epidemiological basis, these parameters were examined as biomarkers of carcinogenesis, especially with regard to asbestos incorporation effects or of radon-induced lung cancers. Also, a possible effect of cigarette smoking and age dependence were studied. A total of 116 male patients with lung or pleural tumours were examined. The histological classification was four small-cell cancers, six large-cell cancers, 32 adenocarcinomas, 47 squamous carcinomas, 12 mixed lung carcinomas, five diffuse malignant mesotheliomas and ten lung metastasis of extrapulmonary tumours. Twenty-two lung cancers and all mesotheliomas were related to asbestos, 22 lung cancers were related to ionizing radiation and 61 patients had cigarette smoke-related lung cancer. Besides these patients 50 male patients with non-malignant lung or pleural diseases were included; of the latter eight subjects suffered from asbestosis. Controls were 129 male subjects without any lung disease. No significantly elevated or decreased serum values for p53 protein, EGF-R, or anti-p53 antibodies as a function of histological tumour type, age, or degree and type of exposure (asbestos, smoking, ionizing radiation) could be found. The utility of p53-protein, EGF-R and anti-p53 antibodies as routine biomarkers for screening occupationally derived lung cancers is limited.  (+info)

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53. (6/382)

Recent investigations have revealed that mutations of the loop-sheet-helix motif of p53 is a significant factor for a poor prognosis in patients with non-small-cell lung cancer (NSCLC). To clarify this mechanism, bcl-2 and bax expression were evaluated in relation to mutations of p53. Tumor tissues of 203 patients with NSCLC were analyzed. Immunohistochemistry was performed to evaluate bcl-2 and bax expression, and polymerase chain reaction single-strand conformation polymorphism following direct sequencing was performed to investigate p53 status. A total of 79 carcinomas were bcl-2 positive, 146 carcinomas were bax positive, and 72 carcinomas had missense mutations of p53. There was no difference in bcl-2 expression in relation to p53 status. On the other hand, tumors with structural mutations of p53 had significantly lower expression of bax than those with wild-type p53 (P = 0.0026). In contrast, tumors with mutations of the loop-sheet-helix motif of p53 had significantly higher expression of bax than those with wild-type p53 (P = 0.0236). The frequency of a bcl-2/bax ratio of >/=1 was significantly lower in tumors with mutations of the loop-sheet-helix motif than that in tumors with wild-type p53 (P = 0.0240). The bcl-2/bax ratio status was a significant factor for a prognosis in patients with NSCLC (P = 0.0083). Mutations of the loop-sheet-helix motif of p53 were correlated with overexpression of bax, while other mutations of p53 were correlated with low levels of bax expression. This variation in pattern of bax expression in relation to mutant p53 might reflect the biological behavior of tumors in patients with bcl-2-positive NSCLC.  (+info)

k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. (7/382)

Environmental carcinogen exposure is requisite for the development of nearly all lung cancer, and it is well known that asbestos exposure interacts synergistically with tobacco smoke to induce lung cancer. However, the precise molecular lesions induced by asbestos are unknown. Furthermore, it is also unknown whether asbestos carcinogenesis proceeds in a fashion independent of or dependent upon the induction of fibrosis in workers with high asbestos exposures. Previous studies have suggested that asbestos is associated with the presence of a k-ras mutation in adenocarcinoma of the lung. We aimed to test whether occupational asbestos exposure was associated with k-ras codon 12 mutations in lung adenocarcinoma tumors and to determine whether this was conditional on the presence of asbestosis. All newly diagnosed, resectable lung cancer patients receiving treatment at the Massachusetts General Hospital between November 1992 and December 1996 were eligible to participate. Because k-ras mutation is very strongly associated with adenocarcinoma, and men were more likely to be occupationally exposed to asbestos, the study was restricted to males with this histological diagnosis. There were 84 male patients with available questionnaire-derived work history data and paraffin-embedded tumor tissue for determination of k-ras mutation status. Chest radiographic evaluation was done for all of the patients who reported occupational exposure to asbestos. The prevalence of k-ras mutation was higher among those with a history of occupational asbestos exposure (crude odds ratio, 4.8; 95% confidence interval, 1.5-15.4) compared to those without asbestos exposure, and this association remained after adjustment for age and pack-years smoked (adjusted odds ratio, 6.9; 95% confidence interval, 1.7-28.6). An index score that weights both the dates of exposure and the estimated intensity of exposure indicated that those with k-ras mutations had significantly greater asbestos exposures than those without mutations (P < 0.01). Analysis of the descriptive components of exposure indicated that the duration of exposure was not associated with k-ras mutation, but that the time since initial exposure was significantly associated with mutation status. The association of k-ras mutation and reported asbestos exposure was not dependent on the presence of radiographic evidence of asbestos-related disease. These data suggest that asbestos exposure increases the likelihood of mutation at k-ras codon 12 and that this process occurs independently of the induction of interstitial fibrosis.  (+info)

Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. (8/382)

BACKGROUND: Several molecular changes, including loss of heterozygosity (i.e., deletion of one copy of allelic DNA sequences) and alterations in microsatellite DNA, have been detected early in the pathogenesis of lung cancer, even in histologically normal epithelium. In the bronchial epithelium of patients with lung cancer, we have determined the frequency, size, and patterns of molecularly abnormal clonal patches. METHODS: We studied formalin-fixed, paraffin-embedded samples from 16 surgically resected lung carcinomas (five squamous cell carcinomas, four small-cell carcinomas, six adenocarcinomas, and one large-cell carcinoma). From each carcinoma, we microdissected foci (each containing about 200 cells) of tumor tissue and equivalent samples of histologically normal and abnormal epithelium. Furthermore, multiple discontinuous foci of bronchial epithelium were analyzed from methanol-fixed samples from three additional patients with lung cancer (two with squamous cell carcinoma and one with adenocarcinoma). We used two-step polymerase chain reaction-based assays involving 12 microsatellite markers at seven chromosomal regions frequently deleted in lung cancer. RESULTS: Two hundred eighteen foci of nonmalignant bronchial epithelium (195 of histologically normal or slightly abnormal epithelium and 23 of dysplastic epithelium) were studied from the 19 surgically resected lobectomy specimens. Thirteen (68%) of the 19 specimens had at least one focus of bronchial epithelium with molecular changes. At least one molecular abnormality was detected in 32% of the 195 histologically normal or slightly abnormal foci and in 52% of the 23 dysplastic foci. Extrapolating from our two-dimensional analyses, we estimate that most clonal patches contain approximately 90 000 cells. Although, in a given individual, tumors appeared homogeneous with respect to molecular changes, the clonally altered patches of mildly abnormal epithelium were heterogeneous. CONCLUSIONS: Our findings indicate that multiple small clonal or subclonal patches containing molecular abnormalities are present in normal or slightly abnormal bronchial epithelium of patients with lung cancer.  (+info)

Large cell carcinoma is a type of lung cancer. The term large cell refers to the appearance of the cancer cells when viewed under a microscope. The tumors associated with this type of cancer are also typically large.
Large cell carcinoma Accounts for 5-10% of all lung cancers. Strongly associated with cigarette smoking. The lesion occurs peripherally and grows rapidly, with early metastases and a poor outcome They lack any diagnosic features to suggest their diagnosis prior to biopsy.
Some of these tumours showed a solid growth pattern of polygonal cells with eosinophilic intracytoplasmic inclusion bodies. Histochemically, these cells were periodic acid-Schiff-negative. Immunohistochemically, vimentin and neuron-specific enolase were positive. Epithelial membrane antigen was focally and weakly positive and p53 was positive in 60% of tumoral cells.. Electron microscopy revealed intracytoplasmic inclusion bodies consisting of whorled intermediate filaments. Based on histological and immunohistochemical findings, the patient was diagnosed as having pulmonary large cell carcinoma with rhabdoid phenotype. Because of its aggressive clinical course, early diagnosis and decision on therapy is very important for this disease.. ...
Background: The magnitude of the link between cigarette smoking and lung cancer may vary by histological type.. Methods: We used polytomous logistic regression to evaluate whether aspects of smoking have different effects across four histological types in the Nurses Health Study.. Results: From 1976 to 2002, we identified 1062 cases of lung cancer: squamous cell (n 201), small cell (n 236), adenocarcinoma (n 543) and large cell carcinoma (n 82), among 65 560 current or former smokers. Risk reduction after quitting ranged from an 8 reduction (relative risk (RR): 0.92, 95 CI 0.91 to 0.94) to a 17 reduction (RR: 0.83, 95 CI 0.80 to 0.86) per year for adenocarcinoma and small cell carcinoma, respectively, with a 9 reduction observed for large cell carcinoma and an 11 reduction observed for squamous cell carcinoma. The association of age at smoking initiation and former cigarette smoking was similar across types, while the association of smoking duration differed. The risk of adenocarcinoma ...
article{cf0dde2a-1de1-4aeb-9f7b-5f410161f5f1, abstract = {Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. EMA reacted with 90%, and NSE with 20% of all histological types. There was no staining for NF. All antibodies, except EMA, were more efficient with surgical specimens. Our study implies that the cytokeratins we used work better with surgical material, but are generally comparable to monospecific cytokeratin antibodies. Also, EMA is a reliable marker for epithelial ...
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Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269,PubMed:15118125, ECO:0000269,PubMed:16533793, ECO:0000269,PubMed:16672372}. Note=The gene represented in this entry is involved in disease pathogenesis ...
Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. {ECO:0000269,PubMed:15118125, ECO:0000269,PubMed:16533793, ECO:0000269,PubMed:16672372}. Note=The gene represented in this entry is involved in disease pathogenesis ...
The heterogeneity of the H460 large cell lung cancer cell line was investigated by selecting for chemokinetic cells from a CON population that demonstrated both chemokinesis and chemotaxis. Using Boyden chambers, cells that migrated under chemokinetic conditions were collected and their numbers expanded. Time-lapsed microscopy under isotropic conditions showed that KINE cells moved faster and changed directions more frequently than CON confirming their chemokinetic character. KINE cells which lacked stable focal adhesion were also less adhesive to culture plates compared to CON cells which had focal adhesions at the leading edge shown by phospho-Paxillin-tyr118 antibody labeling. Weak substrate adhesion in KINE cells may account for motile characteristics of rapid and random movement [16-19]. Furthermore, the selection for increased chemokinesis did not compromise the ability of KINE cells to chemotax. KINE cells were also significantly more invasive compared to CON.. These results underscore ...
Principal Inclusion Criteria: - Female or male patients age , 18 years-old - ECOG performance Status 0 or 1 at study entry - Life expectancy of at least 3 months - Histologically confirmed non-squamous NSCLC (adenocarcinoma, large cell carcinoma, undifferentiated carcinoma or other) - Stage IIIB-IV cancer or delayed relapse of any stage not amenable to surgery or radiotherapy with curative intent. - PD-L1 expression by immunohistochemistry in , 50% of tumor cells - Patients must be chemotherapy-naïve for the advanced stage of the disease. Previous neoadjuvant and/or adjuvant chemotherapy is allowed for patients who successfully underwent complete radical surgery and if last treatment was administered more than 12 months prior to the start of the study treatment. - At least one measurable lesion by CT scan based on RECIST 1.1 performed within 28 days prior to start of study treatment - Adequate hematological, hepatic, and renal functions - Women of childbearing potential (WOCBP) must have a ...
Cellular glutathione (GSH) levels were measured from 27 human lung tumor biopsies, enzymatically disaggregated, and compared with cells isolated from normal lung of the same patients. GSH levels from normal lung were similar among patients with a mean value of 11.20 ± 0.58 (SEM) nmol GSH/mg protein (24 patients) with a range from 6.1 to 17.5 nmol GSH/mg protein. GSH levels varied considerably within and across histological tumor types with the following values: adenocarcinomas, 8.83 ± 0.96 nmol/mg protein (8 patients); large cell carcinomas, 8.25 ± 2.51 nmol/mg protein (3 patients); and squamous cell carcinomas, 23.25 ± 5.99 nmol/mg protein (8 patients). The cyclic GSH reductase assay gave only average GSH values and could not distinguish possible GSH variation among subpopulations of cells isolated. Cell volume measurements and microscopic evaluation of cells isolated from both tumors and normal lung revealed heterogeneity with respect to cell types present. To determine the extent of thiol ...
Large cell neuroendocrine carcinoma in the salivary glands is rare. We report a second case of large cell neuroendocrine carcinoma of the submandibular gland diagnosed at autopsy, and a review of the literature. A 68-year-old Japanese man was referred to our hospital for thorough investigation of swelling on the right side of his neck. Fine-needle aspiration cytology of the cervical mass suggested poorly differentiated metastatic carcinoma. The primary tumor could not be detected by several examinations. One month after admission, he died of cancer. An autopsy was performed, and it revealed a tumor of the right submandibular gland. The histopathological diagnosis was large cell neuroendocrine carcinoma of the submandibular gland. To the best of our knowledge, only eight cases of large cell neuroendocrine carcinoma in the salivary glands, including our case, have been reported. This report indicates total biopsy and immunohistochemistry are necessary for diagnosing large cell neuroendocrine carcinoma
Patients who underwent chemotherapy had longer overall survival. Research presented in the July 2012 issue of the International Association for the Study of Lung Cancers (IASLC) Journal of Thoracic Oncology, concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were treated with perioperative chemotherapy and surgery had better overall survival outcomes than patients treated with surgery alone.. Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. Of those, about 30 percent of patients have limited disease SCLC. Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to SCLC. Surgery in these groups of patients are rare and researchers wanted to know if perioperative chemotherapy would benefit the patients.. The retrospective study looked at 74 patients who underwent lung cancer surgery at the Surgical Centre Marie Lannelongue in Le ...
Two mutually exclusive genomic LCNEC subtypes have been identified by molecular studies: one shows co-mutated TP53 and RB1, which is similar to SCLC, and the STK11/KEAP1 subtype with predominantly RB1 wild-type that is similar to NSCLC.. Reviewing clinical data and tumour specimens of 232 patients in the Netherlands Cancer Registry and Pathology Registry from 2003 to 2012, this retrospective analysis identified 148 patients who had been diagnosed with LCNEC. Of these, samples from all patients receiving first-line chemotherapy for panel-consensus diagnosed LCNEC were included for next-generation sequencing (NGS) for the TP53, RB1, STK11, and KEAP1 genes. RB1 (pRB1, 13A10) was analysed by immunohistochemistry, with samples having an H-score of ≥50 considered positive.. The results of the NGS and pRB1 were correlated with overall survival (OS) and progression-free survival (PFS) by Kaplan Meier plots and Log-rank test.. Quality control of the samples determined that 79 samples were sufficient ...
Disease Ontology : 12 A cervix carcinoma that has material basis in neuroendocrine tissue and is characerized by a diffuse, organoid, trabecular, or cord-like pattern of neoplastic cells with abundant cytoplasm, large nuclei, prominent nucleoli, and a high mitotic rate ...
Die Universität zu Köln ist eine Exzellenzuniversität mit dem klassischen Fächerspektrum einer Volluniversität. Als eine der größen Hochschulen Europas arbeitet sie in Forschung und Lehre auch international auf höchstem Niveau.
M-800:M-800) Neoplasms, NOS M-8000/0 Neoplasm, benign M-8000/1 Neoplasm, uncertain whether benign or malignant M-8000/3 Neoplasm, malignant M-8000/6 Neoplasm, metastatic M-8000/9 Neoplasm, malignant, uncertain whether primary or metastatic M-8001/0 Tumour cells, benign M-8001/1 Tumour cells, uncertain whether benign or malignant M-8001/3 Tumour cells, malignant M-8002/3 Malignant tumour, small cell type M-8003/3 Malignant tumour, giant cell type M-8004/3 Malignant tumour, spindle cell type M-8005/0 Clear cell tumour, NOS M-8005/3 Malignant tumour, clear cell type (M-801:M-804) Epithelial neoplasms, NOS M-8010/0 Epithelial tumour, benign M-8010/2 Carcinoma in situ, NOS M-8010/3 Carcinoma, NOS M-8010/6 Carcinoma, metastatic, NOS M-8010/9 Carcinomatosis M-8011/0 Epithelioma, benign M-8011/3 Epithelioma, malignant M-8012/3 Large cell carcinoma, NOS M-8013/3 Large cell neuroendocrine carcinoma M-8014/3 Large cell carcinoma with rhabdoid phenotype M-8015/3 Glassy cell carcinoma M-8020/3 Carcinoma, ...
The characteristics of 112 patients with COPD were as follows; mild COPD/moderate COPD: number of patients (male) 42 (21)/70 (57), age 71.0/70.5 years-old, pathological stage of NSCLC IA 30/25 IB 5/8 IIA 3/8 IIB 3/4 IIIA 5/19 IIIB 0/1, histology adenocarcinoma (Ad) 29/40 squamous cell carcinoma (Sq) 9/27 large cell neuroendocrine carcinoma (LCNEC) 2/2 pleomorphic carcinoma 0/2 Ad + Sq 1/0 Sq + LCNEC 1/0. Each of OS and DFS was 2287 days (1984 - 2589) and 2015 (1679 - 2351) days in mild COPD patients and 2004 (1873 - 2135) days and 1768 (1656 -1890) days in moderate COPD patients. Compared with patients with mild COPD, patients with moderate COPD had increased risk of worse OS (p = 0.035) but had no differences in CSS (p = 0.867) and DFS (p = 0.125) by log-rank analysis. ...
Small cell carcinoma of the lung (SCLC) together with the large cell neuroendocrine carcinoma (LCNEC), typical carcinoid (TC), and atypical carcinoid (AC) make a group of morphologically identifiable neuroendocrine tumors. The...
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, Busam KJ, de Krijger RR, Dietel M, El-Naggar AK, Fernandez-Cuesta L, Klöppel G, McCluggage WG, Moch H, Ohgaki H, Rakha EA, Reed NS, Rous BA, Sasano H, Scarpa A, Scoazec JY, Travis WD, Tallini G, Trouillas J, van Krieken JH, Cree IA. Mod Pathol. 2018 PMID: 30140036. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors. George J, Walter V, Peifer M, Alexandrov LB, Seidel D, Leenders F, Maas L, Müller C, Dahmen I, Delhomme TM, Ardin M, Leblay N, Byrnes G, Sun R, De Reynies A, McLeer-Florin A, Bosco G, Malchers F, Menon R, Altmüller J, Becker C, Nürnberg P, Achter V, Lang U, Schneider PM, Bogus M, Soloway MG, Wilkerson MD, Cun Y, McKay JD, Moro-Sibilot D, Brambilla ...
Introduction: Lung neuroendocrine tumors (NET) are rare and heterogeneous, with wide range of aggressiveness. Aim: Describe clinical and epidemiologic characteristics, stage, treatment and survival of patients with lung NET according to histological group -[typical carcinoid (TC), atypical carcinoid (AT), large cell neuroendocrine carcinoma (NEC). Methods: Retrospective longitudinal, multicenter study analyzing files of patients diagnosed with NET from 2005 to 2010. Small cell carcinoma was excluded. Comparisons among groups were done with X2. Survival curves were generated using Kaplan-Meier method. Results: 137 patients were included, mean age (SD) 59 (± 14) years; 71 (52%) male; 82 (60%) non-smokers. Histological classification: 54 TC, 49 NEC and 34 AC. Table below describes patients characteristics. Follow-up ranged from 1 to 78 months. Twenty seven patients (20%) died, 1 in TC, 2 in AC, 23 in NEC. The median overall survival (OS) calculated for NEC was 42 months, for other patients median ...
Using enrichment analysis for Gene Ontology Biological Function we see that the genes/proteins with up-regulated PTMs and expression levels are associated with RNA processing, RNA splicing and, gene expression. Re-running the analysis for the sub-cluster of very highly regulated PTMS/genes (the large cluster in the middle) reveals enrichment for neuronal functions including: neuron projection, axon guidance, and neuron morphology. Enrichment for genes that are up-regulated in disease (using the Disease Perturbations from GEO Up library) shows enrichment for neuronal related cancers including: oligodendroglioma, multiple sclerosis, astrocytoma, and large cell neuroendocrine carcinoma. Finally, enrichment using the MGI Mammalian Phenotype library shows enrichment for genes that cause neuronal abnormalities in mice after knockdown including: abnormal neuron morphology, abnormal brain morphology, abnormal spinal cord morphology, and abnormal nervous system. Collectively, these results indicate that ...
The objectives of this research were to test treatment and survival differences between women and men with lung cancer as there is minimal investigation in the literature. Three research questions were developed with statistical testing for gender differences based on similar cancer type, stage, treatment assignment and survival. Data for 44,863 primary lung cancer cases were collected from eight U.S. state-based cancer registries to investigate the research questions. The lung cancer incidence data included the morphological cell-types of adenocarcinoma (AC); squamous cell carcinoma (SCC); large cell carcinoma (LCC) and small cell carcinoma (SCC). Stage, grade, treatment type, as well as, individual characteristics such as gender, age at diagnosis, marital status at diagnosis and race were other variables obtained to be included in the statistical models. Reporting the overall effect for lung cancer gender specific treatment differences or survival has not been demonstrated in the literature to the
Small Cell Cancer (SCLC) is much more rare than Non-Small Cell, only about 15% of cases are Small Cell. Within SCLC, there are three different types: small cell carcinoma (oat cell cancer), mixed small cell/large cell carcinoma and combined small cell carcinoma. Most SCLC cases are oat cell. SCLC is the most aggressive form of lung cancer compared to the other type. It is mainly caused by smoking and starts in the bronchi (breathing tubes) in the center of the chest. This type of lung cancer grows quickly and produces large tumors. Because SCLC grows so quickly, it also metastasizes rapidly to other parts of the body including the brain, liver and bone. Metastasis is when a part of a cancerous tumor breaks off from the original tumor and spreads to another part of the body, spreading the cancer. When you have SCLC, there are many symptoms that come from it, including bloody sputum (spitting up blood), chest pain, coughing, loss of appetite, shortness of breath, weight loss, wheezing, facial ...
Small Cell Cancer (SCLC) is much more rare than Non-Small Cell, only about 15% of cases are Small Cell. Within SCLC, there are three different types: small cell carcinoma (oat cell cancer), mixed small cell/large cell carcinoma and combined small cell carcinoma. Most SCLC cases are oat cell. SCLC is the most aggressive form of lung cancer compared to the other type. It is mainly caused by smoking and starts in the bronchi (breathing tubes) in the center of the chest. This type of lung cancer grows quickly and produces large tumors. Because SCLC grows so quickly, it also metastasizes rapidly to other parts of the body including the brain, liver and bone. Metastasis is when a part of a cancerous tumor breaks off from the original tumor and spreads to another part of the body, spreading the cancer. When you have SCLC, there are many symptoms that come from it, including bloody sputum (spitting up blood), chest pain, coughing, loss of appetite, shortness of breath, weight loss, wheezing, facial ...
Histologically confirmed Non-Small Cell Lung Cancer (NSCLC) of adenocarcinoma, squamous cell carcinoma, large cell carcinoma, or NSCLC not otherwise specified. Patients with suspected NSCLC may enroll prior to the diagnostic biopsy in order to obtain both the diagnostic and molecular analysis-required specimen during the same procedure. Must have blood work within 30 days prior to biopsy to eliminate any unnecessary biopsies on patients that do not qualify (screen failures) due to laboratory values that do not meet the inclusion/exclusion criteria. If a patient has blood work obtained at an outside facility, this can be utilized for the preliminary assessment prior to biopsy, but final inclusion/exclusion values must be obtained within 14 days of start of treatment ...
Results RHAMM expression in the subgroup of large cell carcinomas (LCC) was associated with inferior survival (p=0.000223). Median overall survival was 92 versus 18 months for RHAMM-negative and positive patients, respectively. This survival difference remained significant in both nodal negative and positive patients (pN0: p=0.013 and pN≥1: p=0.007, respectively). P-gp expression was associated with inferior survival in adenocarcinomas (ACA; p=0.013) and appeared to be a postsurgical Union International Contre le Cancer (pUICC)- stage and gender-independent prognostic factor, irrespective of adjuvant chemotherapy, in the multivariable analysis; considering nodal status, this survival difference applied to pN0 cancers (p=0.026).. ...
Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha ...
ACPI: Video: Increase buffer size for writes to brightness proc file. In order to be able to write the value 100 to /proc/acpi/video/.../brightness, we have to allocate 5 bytes: 4 characters will be written (1, 0, 0 plus null byte), and 1 byte should be buffer for a terminating NULL character. http://bugzilla.kernel.org/show_bug.cgi?id=9278 Signed-off-by: Danny Baumann ,[EMAIL PROTECTED], Acked-by: Zhang Rui ,[EMAIL PROTECTED], Signed-off-by: Len Brown ,[EMAIL PROTECTED], --- drivers/acpi/video.c , 2 +- 1 files changed, 1 insertions(+), 1 deletions(-) diff --git a/drivers/acpi/video.c b/drivers/acpi/video.c index dce0a6e..44a0d9b 100644 --- a/drivers/acpi/video.c +++ b/drivers/acpi/video.c @@ -897,7 +897,7 @@ acpi_video_device_write_brightness(struct file *file, { struct seq_file *m = file-,private_data; struct acpi_video_device *dev = m-,private; - char str[4] = { 0 }; + char str[5] = { 0 }; unsigned int level = 0; int i; - To unsubscribe from this list: send the line unsubscribe ...
We are going to change ARM virt ACPI DSDT table, which will cause make check to fail, so temporarily add related golden masters to ignore list. Signed-off-by: Heyi Guo ,[email protected], Reviewed-by: Michael S. Tsirkin ,[email protected], --- Cc: Peter Maydell ,[email protected], Cc: Michael S. Tsirkin ,[email protected], Cc: Igor Mammedov ,[email protected], Cc: Shannon Zhao ,[email protected], Cc: [email protected] Cc: [email protected] --- tests/qtest/bios-tables-test-allowed-diff.h , 3 +++ 1 file changed, 3 insertions(+) diff --git a/tests/qtest/bios-tables-test-allowed-diff.h b/tests/qtest/bios-tables-test-allowed-diff.h index dfb8523c8b..32a401ae35 100644 --- a/tests/qtest/bios-tables-test-allowed-diff.h +++ b/tests/qtest/bios-tables-test-allowed-diff.h @@ -1 +1,4 @@ /* List of comma-separated changed AML files to ignore */ +tests/data/acpi/virt/DSDT, +tests/data/acpi/virt/DSDT.memhp, +tests/data/acpi/virt/DSDT.numamem, -- 2.19.1 ...
The synchronous primary lung tumors is a rare condition and presented patient is the first reported case of simultaneous two distinct neuroendocrine lung cancer lesions in the same lobe. We present the case of a 55-year-old woman with synchronous two distinct neuroendocrine lung cancer lesions in the right upper lobe. Initially she showed no signs or symptoms related to lung lesions and was admitted to Thoracic Surgery Ward for the investigation of two oval, solitary pulmonary nodules (11 and 19 mm in diameter) detected on a chest X-ray performed three months earlier. The radiological imaging showed a variability of growth of both lesions (smaller tumor has enlarged while the larger one remained unchanged). After the CT-guided lung biopsy, patient underwent right upper lobectomy. Histological examination revealed a small cell carcinoma in one of the tumors and a large cell neuroendocrine carcinoma in the other one. The patient was discharged in good condition and lung inflation in chest X-ray ...
2 MANECs are rare entities known to be associated with biological aggressiveness and poor patient survival, but otherwise remain incompletely characterized.3 In a recent study that compared CRC-NE to conventional colorectal carcinoma, CRC-NE was more frequently located in the right colon (76% vs. 46%), more often presented with metastasis (59% vs. 18%) and often had perineural (68%), lymphatic (97%), and venous (62%) invasion and high tumor budding (71%). BRAF V600E mutation was more common in CRC-NE compared with conventional CRC (53% vs. 12%). Neuroendocrine differentiation, high stage, BRAF mutation without microsatellite instability, and signet ring histology were all associated with poor overall survival.4 In the same study, CRC-NE was further divided into large cell neuroendocrine carcinoma (LCNEC), MANEC composed of LCNEC and conventional adenocarcinoma (MANEC-conventional type), and MANEC composed of LCNEC and signet ring cell carcinoma (MANEC-signet ring type). MANEC-signet ring type ...
ABSTRACT. Background: We reported our experience with thymic carcinomas and review their clinical features, treatment strategies, and prognoses. Methods: From April 1998 to November 2012, 11 patients pathologically diagnosed with thymic carcinoma and treated in our hospital were investigated. Results: There were 7 men and 4 women, with a median age of 62 years (range, 35 - 72). According to the Masaoka staging system, 3 patients had stage II, 1 stage III disease, 3 stage IVa disease and 4 stage IVb disease. Ten patients had squamous cell carcinoma, whereas 1 had large cell neuroendocrine carcinoma (LCNEC). We performed surgery or multimodality therapy including surgery as the initial therapy for 8 patients. Of the non-surgical cases, 1 patient received chemoradiotherapy and survived for over 6 years without recurrence, whereas 2 received palliative care. Three of 4 patients who underwent complete resection survived without disease recurrence, whereas only 1 patient with LCNEC survived in the ...
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously ...
Primary neuroendocrine neoplasms of the lung represent a clinical spectrum of tumors ranging from the relatively benign and slow-growing typical carcinoid to the highly aggressive small-cell lung carcinoma. The rarity of carcinoids has made the role of radiation therapy in their management controversial. This review considers the results of published studies to generate treatment recommendations and identify areas for future research. Surgery remains the standard of care for medically operable disease. Histology plays the most important role in determining the role of adjuvant radiation. Resected typical carcinoids likely do not require adjuvant therapy irrespective of nodal status. Resected atypical carcinoids and large-cell neuroendocrine carcinomas have a significant risk of local failure, for which adjuvant radiation likely improves local control. Definitive radiation is warranted in unresectable disease. Palliative radiation for symptomatic lesions has demonstrated efficacy for all histologies.
Results These 93 patients were referred from 12 hospitals and 20 had undergone previous undiagnostic procedures (6 EBUS, 14 bronchoscopy). The mean age was 67 years (range 27 - 87) and 50 were male. 82 were performed under local anaesthesia using lignocaine spray and intravenous midazolam (1 - 10 mg; mean 4 mgs) and the remaining 11 under general anaesthesia. 200 lymph nodes (2R, 4R, 4L, 7, 10R, 10L, 11R) and 13 lung lesions were biopsied. Results were as follows: Adequate samples were obtained in 99% (91/93) and the NSCLC - NOS rate was 2%. 31 adenocarcinoma, 10 squamous cell carcinoma, 10 small cell carcinoma, 1 NSCLC - NOS, 1 large cell neuroendocrine carcinoma, 1 soft tissue lesion (repeat EBUS showed myxoid spindle cell mesenchymal lesion), 1 breast carcinoma, 19 nonspecific benign nodes, 15 sarcoid and 2 TB. There were no complications. ...
This study was terminated on March 8, 2010 due to an analysis by an independent Data Safety Monitoring Committee (DSMC) indicating that the addition of CP-751,871 [figitumumab] to erlotinib [Tarceva] would be unlikely to meet the primary endpoint of improving overall survival when compared to erlotinib alone.. This Oncology study continues as terminated, however for ethical reasons some patients, noted with resultant benefit, continue receiving treatment. ...
Non-small cell lung cancer is the most common type of lung cancer. About 85% of lung cancers are non-small cell lung cancers. Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are all subtypes of non-small cell lung cancer.
Non-small cell lung cancer is the most common type of lung cancer. About 85% of lung cancers are non-small cell lung cancers. Squamous cell carcinoma, adenocarcinoma, and large cell carcinoma are all subtypes of non-small cell lung cancer.
TY - JOUR. T1 - Patterns of practice survey for nonsmall cell lung carcinoma in the U.S.. AU - Choy, Hak. AU - Shyr, Yu. AU - Cmelak, Anthony J.. AU - Mohr, Peter J.. AU - Johnson, David H.. PY - 2000/3/15. Y1 - 2000/3/15. N2 - BACKGROUND. Nonsmall cell lung carcinoma comprises approximately 75% of all lung carcinoma cases in the U.S. Newly evolving strategies have created considerable controversy regarding the optimal treatment for patients diagnosed with this disease. METHODS. A 17-item survey was designed to collect demographic data and information regarding practice patterns for nonsmall cell lung carcinoma, including patient assessment, treatment approaches, and roles of chemotherapy and radiotherapy. Surveys were mailed in the summer of 1997 to approximately 9200 oncologists of all types throughout the U.S. Practice settings included private office, private hospital, academic, university-affiliated office, government, and Veterans Administration institutions. RESULTS. Approximately 10% of ...
Background: More than 50% of new cases of lung cancer are diagnosed in elderly patients. Does age is a factor for deciding the treatment options? The question remains unsolved even in present era as the median survival time of elderly patients was significantly lower compared with that of younger patients. Methods: We conducted a cross sectional study using data base of 175 patients of primary lung cancer with age 60 years and above diagnosed in indoor and outdoor of the Department of Radiotherapy at Regional Cancer Centre, RIMS, Manipur, India from January 2011 to December 2015. Results: The median age at diagnosis was 70years. There were 113 male (64.6%) patients and 62 female (35.4%) patients. The most common radiological presentation was mass (59.4%) followed by collapse-consolidation (22.8%) and pleural effusion (17.8%). Out of 175 patients, 51% of patients had squamous cell carcinoma, adenocarcinoma (33.7%), large cell carcinoma (9.1%) and undifferentiated carcinoma (6%). The median ...
This phase II trial is studying how well erlotinib works in treating patients with advanced primary non-small cell lung cancer. Erlotinib may stop the g
Lung cancer is the leading killer cancer that starts with the abormal growth and duplication of cells in the lungs.. The sad part is that its symptoms appear only at later stages. Lungs are vital organs of the body that bring in fresh oxygen and distribute it to other parts of the body through blood. Moreover, it aids in expelling out the carbodioxide from the blood as well. Thus, if the lungs are affected by cancer, it can endanger your life, and hence it is essential that you take proper care of your lungs. There are basically two types of lung cancer, small cell lung cancer and non-small cell lung cancer. Nearly fifteen percent cases are of the small cell type. This cancer is seen in the bronchi and is present near the center of the chest. Though small, they multiply and spread really fast . The non-small cell lung cancer occurs in nearly eight five percent cases and has three types, viz., adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.. Causes. Smoking and second hand ...
Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). In order for a LCLC to be subclassified as the rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane. The whorled eosinophilic inclusions in LCLC-RP cells give it a microscopic resemblance to malignant cells found in rhabdomyosarcoma (RMS), a rare neoplasm arising from transformed skeletal muscle. Despite their microscopic similarities, LCLC-RP is not associated with rhabdomyosarcoma. Although rhabdoid variants of LCLC are sometimes referred to as rhabdoid carcinomas, this particular term should be reserved for examples of pure rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) Although Colby and colleagues were the ...
The overall survival of patients treated with either the pemetrexed regimen or gemcitabine regimen was found to be non-inferior, with a median survival of 10.3 months. However, when researchers reviewed survival rates according to histological analysis, it was found that patients with adenocarcinoma achieved 12.6 months of overall median survival when treated with the pemetrexed regimen compared to 10.9 months for those treated with the gemcitabine regimen. Patients with large cell carcinoma who were treated with the pemetrexed regimen achieved 10.4 months of overall median survival versus 6.7 months for those treated with the gemcitabine regimen. Both findings are statistically significant ...
Small round malignant cells that grow rapidly and spread throughout the body. Almost all cases of small cell lung cancer is caused by smoking. Also known as Oat Cell cancer. There are three types of lung cancer: Small Cell (Oat Cell), mixed small cell/large cell carcinoma, and combined small cell carcinoma.
Lung cancer can involve a number of abnormalities of oncogenes and tumor suppressor genes ( 13). Biologically, lung cancers are highly invasive and metastatic tumors ( 19). We have determined that the cytoskeletal protein paxillin had elevated levels of paxillin (compared with normal adjacent lung) in NSCLC, especially with higher stages, implicating it in invasion and metastasis. The gene amplification for PXN was also high in large cell carcinoma (17%) compared with other histologies. Interestingly, MET was highly amplified with or without PXN. Because there is precedence in the literature that there are somatic mutations, such as K-ras and EGFR ( 20, 21), and germ-line mutations, such as c-Met ( 4, 14), for a number of genes, we also investigated whether the paxillin gene could be mutated in lung cancer. Somatic paxillin mutations were identified in lung cancer tumor tissue samples. The mutations were particularly clustered between the LD domains, as well as in the LIM domains. Our current ...
Exhibits signaling receptor binding activity. Involved in negative regulation of transcription by RNA polymerase II and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to localize to the SMN complex; SMN-Sm protein complex; and cytosol. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Is expressed in several structures, including alimentary system; branchial arch; metanephros; nervous system; and sensory organ. Orthologous to human STRAP (serine/threonine kinase receptor associated protein ...
...NEW YORK May 15 2012 /- Reportlinker.com announces that...http://www.reportlinker.com/p0606218/Neuroendocrine-Carcinoma-Therapeu...Neuroendocrine Carcinoma Therapeutics - Pipeline Assessment and Market...GlobalData has estimated that the global neuroendocrine carcinoma ther...,Neuroendocrine,Carcinoma,Therapeutics,-,Pipeline,Assessment,and,Market,Forecast,to,2019,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology
Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, EGFR and EML4-ALK, and inactivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes ...
ACPI 3.0 includes UUID-labelled vendor-defined resources (section 6.4.3.2), so move the code that supports this from arch/ia64 into ACPI proper. Len, Tony, this touches both acpi and ia64. Probably easiest if Tony acks it and Len decides whether to apply it. HP owns all the copyrights on the code being moved, and we agree that the code being moved into the ACPI CA may be used under either the GPL or the BSD-style license used by the ACPI CA. (There should be something in Documentation/acpi about how to contribute to the ACPI CA. Its a royal pain in the rear :-)). Signed-off-by: Bjorn Helgaas ,[email protected], ===== arch/ia64/kernel/acpi-ext.c 1.5 vs edited ===== Index: work-vga2/arch/ia64/kernel/acpi-ext.c =================================================================== --- work-vga2.orig/arch/ia64/kernel/acpi-ext.c 2005-09-14 09:28:07.000000000 -0600 +++ work-vga2/arch/ia64/kernel/acpi-ext.c 2005-09-15 14:52:33.000000000 -0600 @@ -1,105 +1,45 @@ /* - * arch/ia64/kernel/acpi-ext.c + * ...
In this study, we aimed to evaluate the data of patients diagnosed with primary breast neuroendocrine carcinoma. METHODS: Patients with more than 50% neuroendocrine differentiation identified in the histopathological examination between January 2010 and January 2015 and who had no other focus on imaging were evaluated retrospectively from the hospital registry system. Patients with secondary n...
Objective: To investigate the clinicopathologic characteristics, diagnostic features and prognosis of primary renal neuroendocrine carcinoma (NEC). Methods: The clinicopathologic data of eight cases of renal NEC was collected from January 2008 to December 2017 from Affiliated Hospital of Qingdao University.
My brother has very aggressive, widely metastasized neuroendocrine carcinoma. From what I understand, its treated very differently than carcinoids and NETs, which are slow-growing. Im having a horrible time finding a specialist with experience with theaggressiveform. Does anybody know how I find a good specialist? We need help SOON!. ...
Stefano Bacchetti, Enrico Maria Pasqual, Alessandra Rinaldo and Alfio Ferlito-Current Advances in Diagnosis of Hepatic Metastases from Neuroendocrine Carcinomas
Old Synopsis: hw.acpi.thermal.tz0.temperature shows strange value New Synopsis: [acpi] hw.acpi.thermal.tz0.temperature shows strange value Responsible-Changed-From-To: freebsd-bugs-,freebsd-acpi Responsible-Changed-By: linimon Responsible-Changed-When: Fri Jan 20 09:00:34 UTC 2012 Responsible-Changed-Why: Over to maintainer(s). http://www.freebsd.org/cgi/query-pr.cgi?pr=164329 ...
Prof Sandip Patel speaks to ecancer at the 2019 American Association for Cancer Research (AACR) meeting about the DART study, which examined the administrati
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In 1879, Arnold examined sarcoma and carcinoma cells having very large nuclei. Today, the study of molecular cytogenetics can ... Removing the cell culture and isolation step dramatically simplifies and expedites the process. Using similar principles to CGH ... Cancer cells often accumulate complex chromosomal structural changes such as loss, duplication, inversion or movement of a ... FISH allows one to visualize different parts of the chromosome at different stages of the cell cycle. FISH can either be ...
This may lead to mutations or large genome abnormalities, which can threaten the cell or organism's ability to live. Several ... Mismatch repair defects, for example, cause instability that predisposes to colorectal and endometrial carcinomas. DNA lesions ... However, these drugs can not tell the difference between sick and healthy cells, resulting in the damage of normal cells. ... If the damage is not too extensive, precancerous or cancerous cells are created from healthy cells. Chemotherapeutics, by ...
It is also developing T cell product candidates to treat acute myeloid leukemia, Merkel-cell carcinoma, diffuse large B-cell ... Ide-cel is a BCMA-directed genetically modified autologous CAR-T-cell immunotherapy. In August 2018, the company announced a ... Celgene Corporation and bluebird bio Announce bb2121 Anti-BCMA CAR-T Cell Therapy Has Been Granted Breakthrough Therapy ... The company is developing LentiGlobin gene therapy for the treatment of sickle cell disease and cerebral adrenoleukodystrophy. ...
Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm. Sebaceous glands are normal ... Sebaceous carcinoma of the oral cavity has been reported, presumably arising from Fordyce granules or hyperplastic foci of ... Large numbers of lobules coalescing into a definitely elevated mass may be called benign sebaceous hyperplasia, and occasional ... It is estimated about 80% of people have oral Fordyce spots, but seldom are granules found in large numbers. They are not ...
... made U.S. tabloid headlines in March 1984 when entertainer Andy Kaufman, diagnosed with large cell carcinoma (a ... Practitioner Jun Labo claimed to have removed large cancerous tumors and Kaufman declared he believed this cancer had been ...
... of lung cancers are large-cell carcinoma. These are so named because the cancer cells are large, with excess cytoplasm, large ... Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... The three main subtypes of NSCLC are adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma.[1] ... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ...
The tissue of this tumor contains many different types of cells including the rhabdoid cells, large spindled cells, epithelial ... Three siblings had a mutation of the SMARCB1 gene and one had a choroid plexus carcinoma and two had an AT/RT. Although the ... Large tumor cells, eccentricity of the nuclei, and prominent nucleoli are consistent findings. Usually only a minority of AT/RT ... After therapy these cells are given back to the child to regrow the bone marrow. Stem cell rescue or autologous bone marrow ...
... largecell lung carcinoma, rhabdomyosarcoma, melanoma, as well as most squamous cell carcinomas. In the case of collective ... type 1 lung alveolar cells, skeletal muscle cells, placenta, etc. Podoplanin expression in breast cancer cells induces cell ... Single cell invasion or individual cell migration Such a type of invasive growth as single cell invasion is distinguished based ... of the cells that form this type of structures varies from small cells with moderate cytoplasm and round nuclei to large cells ...
high grade neuroendocrine carcinoma, ICD-O 8246/3) *z dużych komórek (ang. large cell neuroendocrine carcinoma, ICD-O 8013/3) ... squamous cell carcinoma, ICD-O 8070/3). *rak z limfoidnym podścieliskiem (rdzeniasty) (ang. carcinoma with lymphoid stroma ( ... signet ring cell carcinoma and other variants; poorly cohesive carcinoma, ICD-O 8490/3) ... Signet ring cell carcinoma of the stomach is significantly associated with poor prognosis and diffuse gastric cancer (Lauren's ...
Overview at Mayo Clinic Large Cell and Giant Cell Carcinoma,+Giant+Cell at the US National Library of Medicine Medical Subject ... Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are ... Giant cell tumors include giant-cell tumor of bone and giant-cell tumor of the tendon sheath. Medicine portal Anaplastic large- ... cell lymphoma Buttock cell Nosology Giant+Cell+Tumors at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Specific types include: anaplastic astrocytoma anaplastic large-cell lymphoma anaplastic meningioma anaplastic thyroid cancer. ... such as the glandular formation or special cellular junctions that are typical of adenocarcinoma and squamous cell carcinoma, ... Anaplastic carcinoma is a general term for a malignant neoplasm arising from the uncontrolled proliferation of transformed ... cells of epithelial origin, or showing some epithelial characteristics, but that reveal no cytological or architectural ...
Carcinoma of the tonsil is a type of squamous cell carcinoma. The tonsil is the most common site of squamous cell carcinoma in ... Large lesions and those which invade bone require wide surgical excision with hemimandibulectomy and neck dissection (Commando ... Squamous cell carcinoma was the most common reported cell type (88%); cases with Lymphoepithelioma had the highest incidence of ... Squamous Cell Carcinoma of the Tonsil)". MyVMC.com. 2003-01-08. Retrieved 2016-07-16. Mankekar, G. (2000). "Tonsillar carcinoma ...
Melanoma Clear-cell sarcoma of the kidney List of cutaneous conditions Hyalinizing clear cell carcinoma - has the same ... It causes either pain or tenderness but only until it becomes large enough. This kind of tumor is commonly found in the ... Clear cell sarcoma of the soft tissues in adults is not related to the pediatric tumor known as clear cell sarcoma of the ... Few cases of clear cell sarcoma respond to chemotherapy. Several types of targeted therapy that may be of benefit to clear cell ...
... a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells ... signet ring cell Signet ring adenocarcinoma cell Signet ring melanoma cell Signet ring stromal cell The name of the cell comes ... They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell ... SRC carcinomas can be classified using immunohistochemistry. Signet ring cell carcinoma Cancer Research UK. Signet Ring Cancer ...
... (code 8070/3) Large-cell keratinizing squamous cell carcinoma (code 8071/3) Large-cell nonkeratinizing ... Adenoid squamous cell carcinoma Basaloid squamous cell carcinoma Clear-cell squamous cell carcinoma Spindle-cell squamous cell ... Signet ring-cell squamous cell carcinoma (occasionally rendered as signet ring-cell squamous cell carcinoma) is a histological ... squamous cell carcinoma (code 8072/3) Small-cell keratinizing squamous cell carcinoma (code 8073/3) Spindle-cell squamous cell ...
As expected, patients with carcinoma usually present larger tumors than patients with adenoma. Rarely, the cancer can spread to ... A Hürthle cell is larger than a follicular cell, and its cellular material stains pink. Hürthle cells also tend to be large, ... The mitochondrial DNA of Hürthle cell carcinoma contain somatic mutations. Hürthle cell carcinomas consists of at least 75% ... show Hürthle cells present. Hürthle cell adenomas are most likely diagnosed much more frequently than Hürthle cell carcinomas. ...
EBV appears to cause all nonkeratinizing nasopharyngeal carcinomas, Epstein-Barr virus-positive diffuse large B-cell lymphomas ... "Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell ... Merkel cell polyomavirus is the most recently discovered human cancer virus, isolated from Merkel cell carcinoma tissues in ... About 80% of Merkel cell carcinomas are caused by Merkel cell polyomavirus; the remaining tumors have an unknown etiology and ...
Small cell lung cancer Non-small cell lung cancer Adenocarcinoma of the lung Squamous cell carcinoma of the lung Large cell ... Prostate cancer, germ cell cancer and renal cell carcinoma may also metastasize to the lung. Treatment of respiratory system ... They are characterized by a high inflammatory cell recruitment (neutrophil) and/or destructive cycle of infection, (e.g. ... Malignant tumors of the respiratory system, particularly primary carcinomas of the lung, are a major health problem responsible ...
... such as small cell carcinoma and large cell neuroendocrine carcinoma. The issue of differential diagnosis is particularly acute ... basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct ... A useful marker panel for distinguishing small cell carcinoma of lung from poorly differentiated squamous cell carcinoma of ... Basaloid squamous cell carcinoma usually begins centrally, in the larger proximal bronchi. Basaloid carcinoma primary in the ...
The rate of incidence varies from 0.5 to 4%.[3] Cytologically, the cells of apocrine carcinoma are relatively large, granular, ... Apocrine carcinomaEdit. Apocrine carcinoma is a very rare form of female breast cancer. ... The apical portion of the secretory cell of the gland pinches off and enters the lumen. It loses part of its cytoplasm in their ... Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in the breast in the context ...
... cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma ... combined large cell neuroencrine carcinoma, and mucinous bronchioloalveolar carcinoma and combined small cell lung carcinoma. ... "Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine ... Chetty R (August 2000). "Combined large cell neuroendocrine, small cell and squamous carcinomas of the lung with rhabdoid cells ...
Topical chemotherapy might be indicated for large superficial basal-cell carcinoma for good cosmetic outcome, whereas it might ... basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant melanoma. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... and squamous-cell carcinoma.[38] There is little evidence that it is effective in preventing basal-cell carcinoma.[39] Other ...
Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Salivary gland-like carcinomas of the lung generally refers a class of rare cancers that arise from the uncontrolled cell ... Carcinoma is a term for malignant neoplasms derived from cells of epithelial lineage, and/or that exhibit cytological or tissue ... epithelial-myoepithelial carcinoma of the lung, and other (even more rare) variants. . Lung cancer is a large and exceptionally ...
C) Signet ring carcinoma: More than 50% of signet cells with infiltrative growth pattern (thin red arrow) or floating in large ... C) Clear cell carcinoma: clear cell cytoplasm identified in polygonal cells with a central nucleus, columnar cells with an ... D) Hepatoid carcinoma: large polygonal-shaped cells, with granular eosinophilic cytoplasm, prominent nucleoli and trabecular ... B) Squamous carcinoma: morphologically similar to other squamous cell carcinomas occurring in other organs with possible ...
... and is the first drug that has been specifically shown to improve survival in large cell carcinoma.[citation needed] ... See also: Combined small-cell lung carcinoma. The term "combined small-cell lung carcinoma" (c-SCLC) refers to a multiphasic ... and is the first drug to reveal differential survival benefit in large cell lung carcinoma.[4][31] ... About 2% of all lung cancers are non-carcinoma (mainly sarcoma, tumors of hematopoietic origin, or germ cell tumors.[5] These ...
... is also used in Kerr cells, as it has an unusually large Kerr constant. Evidence suggests its use in agriculture ... and thyroid adenomas and carcinomas in rats. It is classified as an extremely hazardous substance in the United States as ... It is produced on a large scale from benzene as a precursor to aniline. In the laboratory, it is occasionally used as a solvent ...
These cells are large and have a pale stain compared with the follicular cells. In teleost and avian species these cells occupy ... When parafollicular cells become cancerous, they lead to medullary carcinoma of the thyroid. List of human cell types derived ... Parafollicular cells, also called C cells, are neuroendocrine cells in the thyroid. The primary function of these cells is to ... Parafollicular cells are pale-staining cells found in small number in the thyroid and are typically situated basally in the ...
Large cell carcinoma. Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm.. Small ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ... spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge ...
... the largest number of which had recurrent squamous cell carcinomas. Kato et al. have reported on a series of 26 patients with ... The selective destruction of brain tumor (glioma) cells in the presence of normal cells represents an even greater challenge ... locally recurrent squamous cell carcinomas of the head and neck region.[12] Patients received either two or, in a few instances ... Doses up to 60-70 Grays (Gy) can be delivered to the tumor cells in one or two applications compared to 6-7 weeks for ...
Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ... The most common types of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, but there are several ... Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC ... LCLC is differentiated from small cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Large nodules were previously called cysts. The term nodulocystic has been used in the medical literature to describe severe ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ...
Oral carcinoma[edit]. Patients after HSCT are at a higher risk for oral carcinoma. Post-HSCT oral cancer may have more ... In the case of a bone marrow transplant, the HSC are removed from a large bone of the donor, typically the pelvis, through a ... who have lost their stem cells after birth. Other conditions[13] treated with stem cell transplants include sickle-cell disease ... Peripheral blood stem cells[26] are now the most common source of stem cells for HSCT. They are collected from the blood ...
Squamous cell carcinoma may occasionally develop, usually in chronic cases, and at the edge of ulcer.[citation needed] Tetanus ... Large infected ulcers may require debridement under anesthesia. Skin grafting may be helpful in advanced cases to ensure the ... Chronic ulcers involve larger area and may eventually develop into squamous epithelioma after 10 years or more. Skin color: ...
The removal of cells for biopsy, using a needle Clinical features[edit]. Clinical features can be found in the subhyoid portion ... Thyroglossal duct cyst carcinoma[edit]. Rarely, cancer may be present in a thyroglossal duct cyst. These tumors usually arise ... especially if the cyst becomes large. ... Thyroglossal duct carcinoma occurs in approximately 1 to 2% of ... Thyroglossal cysts can be defined as an irregular neck mass or a lump which develops from cells and tissues left over after the ...
Giant cells - considerably larger than their neighbors - may form and possess either one enormous nucleus or several nuclei ( ... Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ...
... or tumors such as lymphoma or squamous cell carcinoma. A tonsillolith (also known as a "tonsil stone") is material that ... However, they are largest relative to the diameter of the throat in young children. In adults, each palatine tonsil normally ... These M cells then alert the underlying B cells and T cells in the tonsil that a pathogen is present and an immune response is ... The tonsils have on their surface specialized antigen capture cells called M cells that allow for the uptake of antigens ...
BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ... Truswell, AS (Mar 2002). "Meat consumption and cancer of the large bowel". European Journal of Clinical Nutrition. 56 (Suppl 1 ... In the 18th century a scrotal cancer of chimney sweepers, the chimney sweeps' carcinoma, was already known to be connected to ... BaP has an effect on the number of white blood cells, inhibiting some of them from differentiating into macrophages, the body's ...
... cancer that begins in egg cells).. *Mucinous appendiceal carcinoma: A type of cancer that begins in cells that line the ... However, the surgical removal of large pleural deposits with infusion of hyperthermic chemotherapy may offer significant ... Most ovarian cancers are either ovarian epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or ... uterine and renal cell carcinoma among others ; as well as certain sarcomas and pseudomyxoma peritonei. ...
Basal cell carcinoma Fleshy, growing mass Areas exposed to the sun Squamous cell carcinoma Unusual growth that is red, scaly or ... Started with a single scaly, red and slightly itchy spot, and within a few days, did large numbers of smaller patches of the ... Large red bumps that seem to bruise and are tender to touch Anywhere ... Small red dots on the skin, or larger, bruise-like spots that appeared after taking medicine Anywhere ...
cell maturation. • Wnt signaling pathway. • embryonic camera-type eye development. • multicellular organism development. • cell ... Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family ... "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S. ... T cell differentiation in thymus. • chorionic trophoblast cell differentiation. • positive regulation of protein targeting to ...
Glioblastomas are the most common primary malignancies to hemorrhage while thyroid, renal cell carcinoma, melanoma, and lung ... These arteries are the large blood vessels in your neck that feed your brain. Transcranial Doppler (TCD): Transcranial Doppler ... Hemorrhagic transformation of an ischemic infarct Cerebral venous thrombosis Sympathomimetic drug abuse Moyamoya Sickle cell ...
The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. ... Shimada S, Matsuzaki H, Marutsuka T, Shiomori K, Ogawa M (July 2001). "Gastric and intestinal phenotypes of gastric carcinoma ... In fact, 70% of dimeric phosphorylase in the cell exists as bound to glycogen granules rather than free floating.[9] ... Although the reaction is reversible in solution, within the cell the enzyme only works in the forward direction as shown below ...
Large blue. A few hours to a few days Lymphocyte. 30%. Small lymphocytes 7-8. Large lymphocytes 12-15. *B cells: releases ... carcinoma ... T cells: *CD4+ helper T cells: T cells displaying co-receptor ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ... CD8+ cytotoxic T cells: T cells displaying co-receptor CD8 are known as CD8+ T cells. These cells bind antigens presented on ...
"The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves". Plant & Cell ... Moreover, superoxide dismutase has the largest kcat/KM (an approximation of catalytic efficiency) of any known enzyme (~7 x 109 ... including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts ... The cytosols of virtually all eukaryotic cells contain an SOD enzyme with copper and zinc (Cu-Zn-SOD). For example, Cu-Zn-SOD ...
Although derived from a colon (large intestine) carcinoma, when cultured under specific conditions the cells become ... 1983). "Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture". Biol Cell. ... Caco-2 cells are most commonly used not as individual cells, but as a confluent monolayer on a cell culture insert filter (e.g ... 2005). "The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell ...
Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... which often form large amorphous aggregates in the cell, can be degraded directly by the 20S core particle without the 19S ... "Cell. 137 (1): 133-45. doi:10.1016/j.cell.2009.01.041. PMC 2668214. PMID 19345192.. ... Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ...
It is thought[citation needed] that all molds may produce mycotoxins and thus all molds may be potentially toxic if large ... This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction ... "Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment". Environmental Health Perspectives. 118 (6): ... McCormick A, Loeffler J, Ebel F (November 2010). "Aspergillus fumigatus: contours of an opportunistic human pathogen". Cell. ...
... is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus ... Various types of CD30-positive T cell lymphomas[11]. *CD30-positive cases of the NK cell lymphoma, extranodal NK/T-cell ... "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". ... "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor ...
A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a ... Large residual masses found after chemotherapy may require surgical resection. Second-line treatment is the same as for ... Embryonal carcinoma. *Endodermal sinus tumor/Yolk sac tumor. *Teratoma: Fetus in fetu ... Weidner N (February 1999). "Germ-cell tumors of the mediastinum". Seminars in Diagnostic Pathology. 16 (1): 42-50. PMID ...
... mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[5] Large amounts of TNF are released ... Treatment of renal cell carcinoma with infliximab resulted in prolonged disease stabilization in certain patients. Etanercept ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ... NK cells, neutrophils, mast cells, eosinophils, and neurons.[5] TNFα is a member of the TNF superfamily, consisting of various ...
Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... 2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV. The GEC ESTRO handbook of brachytherapy. Belgium ... Due to their relatively large mass, protons and other charged particles have little lateral side scatter in the tissue-the beam ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ...
Virchow's cell, a macrophage in Hansen's disease. *Virchow's cell theory, omnis cellula e cellula - every living cell comes ... It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... From it, he coined a well known aphorism: "Medicine is a social science, and politics is nothing else but medicine on a large ... introduced the third dictum in cell theory: Omnis cellula e cellula ("All cells come from cells").[9] He was a co-founder of ...
The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... This often presents itself as a lump of tissue near the anus which grows larger and more painful with time. Like other ... The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt ...
Originally started a laryngeal carcinoma strain, the cell line was contaminated and displaced by HeLa cells, and has now been ... They are superior to the previously used animal tissues because of their large size and the high rate of mitosis (cell division ... T-cells and B-cells) and antigen presenting cells. These cells coordinate an immune response upon the detection of foreign ... Hargraves M, Richmond H, Morton R. Presentation of two bone marrow components, the tart cell and the LE cell. Mayo Clin Proc ...
... large cell lymphoma of the B-cell type, although T cell lymphomas have also been described. ... The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other ... Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common ... Large deep orbital dermoid cysts can cause pressure effects on the muscles and optic nerve, leading to diplopia and loss of ...
... integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large ... "Expression of cadherin-8 in renal cell carcinoma and fetal kidney". International Journal of Cancer. 101 (4): 327-34. doi: ... cell-cell junction assembly. • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. • cell-cell ... cell-cell adherens junction. • cell surface. • catenin complex. Biological process. • response to cold. • cell adhesion. • ...
Cell Tropism[edit]. Hepadnaviruses, as their "hepa" name implies, infect liver cells and cause hepatitis. This is true not only ... The L (for "large") envelope protein contains all three subunits. The M (for "medium") protein contains only preS2 and S. The S ... Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ... The virus binds to specific receptors on cells and the core particle enters the cell cytoplasm. This is then translocated to ...
Mostly these are squamous cell carcinomas.[17][18]. Food debris, desquamated epithelial cells and bacteria often form a visible ... Tongues of seals and whales have been eaten, sometimes in large quantities, by sealers and whalers, and in various times and ... The tongue is equipped with many taste buds on its dorsal surface, and each taste bud is equipped with taste receptor cells ... Chemicals that stimulate taste receptor cells are known as tastants. Once a tastant is dissolved in saliva, it can make contact ...
Small cell carcinoma is a very rare (1%[77]) type of prostate cancer that cannot be diagnosed using the PSA.[77][78] As of 2009 ... Two large genome-wide association studies linking single nucleotide polymorphisms (SNPs) to prostate cancer were published in ... lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration". Cell Stem ... "Small-cell carcinoma of the prostate". Journal of the Royal Society of Medicine. 90 (6): 340-1. PMC 1296316 . PMID 9227387.. ...
... large-cell carcinoma, small-cell carcinoma, or non-cancer.. Close Relation of Large Cell Carcinoma to Adenocarcinoma by ... Large cell carcinoma of lung: On the verge of extinction?. Large cell carcinoma of the lung: a tumor in search of an author. A ... Large cell carcinoma of the lung. Ultrastructural and immunohistochemical features.. Large cell carcinoma of the lung with ... Undifferentiated Large Cell Carcinoma. According to some authors the existence of Large Cell Carcinoma as a definite entity has ...
Large cell carcinoma. Typically occurring in lung cancer, the cells are known for their large, rounded shape when seen under a ...
The term large cell refers to the appearance of the cancer cells when viewed under a microscope. The tumors associated with ... Large cell carcinoma is a type of lung cancer. ... this type of cancer are also typically large. ... Large cell carcinoma is a type of lung cancer. The term large cell refers to the appearance of the cancer cells when viewed ... Large cell carcinoma is responsible for about ten percent of the non-small cell lung cancer diagnosis. It grows more rapidly ...
Large cell carcinoma Accounts for 5-10% of all lung cancers. Strongly associated with cigarette smoking. The lesion occurs ... STAGING OF BRONCHOGENIC CA NSCLC STAGING TNM CLASSFICATION Adenocarcinoma Squamous cell carcinoma Large cell carcinoma T - ... Large cell carcinoma Accounts for 5-10% of all lung cancers.. Published byAlexis Joplin Modified over 3 years ago ... 2 Large cell carcinoma Accounts for 5-10% of all lung cancers.. Strongly associated with cigarette smoking. The lesion occurs ...
... per year for adenocarcinoma and small cell carcinoma, respectively, with a 9 reduction observed for large cell carcinoma and an ... small cell (n 236), adenocarcinoma (n 543) and large cell carcinoma (n 82), among 65 560 current or former smokers. Risk ... 10 for squamous cell and 12 for small cell. The 6 difference between adenocarcinoma and small cell carcinoma is equivalent to a ... The risk of adenocarcinoma increased by 6 per year of smoking, compared to 7 for large cell, ...
... of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the ... of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the ... of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. CEA stained 33% and 60% of the ... small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which ...
... squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a ... The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes ... High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to ... Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different ...
Large-cell carcinomas can begin in any part of the lung and tend to grow very quickly. ... of all lung cancers are large-cell carcinomas. There is some dispute as to whether these constitute a distinct type of cancer ... or are merely a group of unusual squamous cell carcinomas and adenocarcinomas. ... Other articles where Large-cell carcinoma is discussed: … ... Large-cell carcinoma. pathology. THIS IS A DIRECTORY PAGE. ...
... cell lung carcinoma Small cell lung carcinoma Adenocarcinoma of the lung Large cell lung carcinoma Adenosquamous carcinoma ... combined large cell neuroencrine carcinoma, and mucinous bronchioloalveolar carcinoma and combined small cell lung carcinoma. ... "Clinical characterization of pulmonary large cell neuroendocrine carcinoma and large cell carcinoma with neuroendocrine ... Chetty R (August 2000). "Combined large cell neuroendocrine, small cell and squamous carcinomas of the lung with rhabdoid cells ...
Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to ... Chemotherapy Effective For Patients With Resected SCLC Or Large-Cell Neuroendocrine Carcinoma. by editor ... concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were ... Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. Of those, about 30 percent of patients have ...
... but Memorial Sloan Kettering experts have experience treating both large cell neuroendocrine carcinoma and small cell carcinoma ... Gastrointestinal small cell carcinoma and large cell carcinoma are usually diagnosed at an advanced stage, after they have ... The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. ... Because small cell and large cell neuroendocrine carcinomas of the gastrointestinal tract are usually found at an advanced ...
Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study ... Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been ... In recent years, large cell neuroendocrine carcinomas (LCNEC) that differ in cell morphology compared with small cell carcinoma ... A Case of the Large Cell Neuroendocrine Carcinoma of the Urinary Bladder,. Case Reports in Medicine,. vol. 2013. ,. Article ID ...
... with the three most common ones being small cell carcinoma, large cell neuroendocrine carcinoma and carcinoid tumors. Based on ... Morphologically, it is the large cell carcinoma in which tumor cells are typically more than three times greater than the ... Large cell neuroendocrine carcinoma primarily in the pericardium. a case report and literature review. Yin, Yue1; Zhang, Yun1; ... Large cell neuroendocrine carcinoma of the endometrium: a case report and literature review. Taiwan J Obstet Gynecol 2018; 57: ...
Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to ... Chemotherapy effective for patients with resected SCLC or large-cell neuroendocrine carcinoma. 18.06.2012 ... concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were ... Further reports about: , Association , IASLC , SCLC , Small-cell lung cancer , cell lung cancer , chemotherapy , lung cancer , ...
... P. N. Shakuntala,1 K. Uma ... C. F. Lindboe, "Large cell neuroendocrine carcinoma of the ovary," APMIS, vol. 115, no. 2, pp. 169-176, 2007. View at Publisher ... P. Dundr, D. Fischerová, C. Povýšil, and D. Cibula, "Primary pure large-cell neuroendocrine carcinoma of the ovary," Pathology ... J. M. Kim, H. C. Shin, and M. J. Kim, "Ovarian large cell neuroendocrine carcinoma associated with endocervical-like mucinous ...
What is large cell carcinoma? Meaning of large cell carcinoma medical term. What does large cell carcinoma mean? ... Looking for online definition of large cell carcinoma in the Medical Dictionary? large cell carcinoma explanation free. ... large cell carcinoma, and squamous cell carcinoma.. oat cell carcinoma a form of small cell carcinoma in which the cells are ... large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.. cholangiocellular carcinoma a rare type of ...
Akamatsu S, Kanamaru S, Ishihara M, Sano T, Soeda A, Hashimoto K. Primary large cell neuroendocrine carcinoma of the urinary ... Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virch Arch 2006;449:135-136 ... Hao H, Itoyama M, Tsubamoto H, Tsujimoto M, Hirota S. Large cell neuroendocrine carcinoma of the cervix associated with ... Deodhar KK, Kerkar RA, Suryawanshi P, Menon H, Menon S. Large cell neuroendocrine carcinoma of the endometrium: an extremely ...
... but patients with large tumors (> 5 cm) have elevated rates of locoregional recurrence. With conformal radiation... ... Dose escalation Anal cancer Large tumors Overall survival benefit Squamous cell carcinoma ... The effect of dose escalation for large squamous cell carcinomas of the anal canal. ... Squamous cell carcinoma of the anus at one hospital from 1948 to 1984. Br J Surg. 1989;76:806-10.CrossRefGoogle Scholar ...
Learn the symptoms, treatments, and prognosis of large cell carcinoma of the lungs. ... Large cell carcinoma is a form of non-small cell lung cancer. ... Large cell carcinomas are also called large cell lung cancers. ... One variant of large cell carcinoma, large cell neuroendocrine carcinoma, has a poorer prognosis than large cell carcinoma. ... Large cell carcinoma of the lungs is a form of non-small cell lung cancer. Non-small cell lung cancers account for 80 percent ...
SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma. The safety and scientific validity of this study is ... Part 1A is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with ... Small Cell Lung Carcinoma. Carcinoma, Neuroendocrine. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic ... This is a Phase 1a/1b study of SC-002 in patients with relapsed small cell lung cancer (SCLC) or large cell neuroendocrine ...
... sequencing of pulmonary large cell neuroendocrine carcinoma reveals small cell carcinoma-like and non-small cell carcinoma-like ... Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg 2005;130:166-72 ... Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell ... Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung. Tomohiro Miyoshi, Shigeki Umemura, Yuki Matsumura, ...
HomeIndustry SolutionsOncologyPreclinicalCell LinesNCI-H1299-Luc: Human Large Cell Lung Carcinoma ... Please note that cell lines are not for sale and unavailable for purchase from Covance.*** ... Cell LinesTumor ModelsCAR TIn VitroTumor SpotlightsPosters Choose Subcategory. Cell Lines. Tumor Models. CAR T. In Vitro. Tumor ... Biomarker Solutions Biomarker Solution Center Companion Diagnostics Genomics Solutions Cell and Gene Therapies Immuno-Oncology ...
The RNA-seq profile of LCLC and other non-small cell lung carcinoma (NSCLC) was downloaded from Gene Expression Omnibus (GEO) ... This study also finds tools to diagnose LCLC and differentiate LCLC with other Non-Small Cell Lung Cancer. ... We also identified the LncRNA differentially expressed in LCLC compared to lung squamous carcinoma (LUSC) and Lung- ... Undifferentiated large cell lung carcinoma (LCLC) accounts for 2.9-9% of total lung cancers. Recently, RNA-seq based studies ...
Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma (NICCI). The safety and ... Patients with at least 1 large (≥ 2 cm in diameter in head/neck region, ≥ 5 cm for trunk/extremities) basal cell carcinoma (BCC ... Patients with large (as defined above) recurrent basal cell carcinoma are also eligible. ... Carcinoma, Basal Cell. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Basal Cell. ...
A 73 year-old man presented with a large ulcerated plaque almost completely covered with a thick hemorrhagic black crust on the ... Large basal cell carcinoma of the scalp. Zeitschrift:. Wiener Medizinische Wochenschrift > Ausgabe 5-6/2017 Autoren:. MD José ... Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical approach. ... Erratum to: Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical ...
Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. Jules L. Derks, ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ...
Large Cell Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma, Adenosquamous Cell CarcinomaTrial Of CP-751, 871 ... Large Cell Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma, Adenosquamous Cell Carcinoma ... Non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. At least 1 ... Non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. At least 1 ...
... small cell neuroendocrine carcinoma, squamous cell carcinoma, adenocarcinoma and large cell carcinomas ... There are four major types of lung carcinomas, ... Large cell carcinoma of the lung - a vanishing entity? Autor:. ... Large cell carcinoma of the lung - a vanishing entity?. Zeitschrift:. memo - Magazine of European Medical Oncology > Ausgabe 1/ ... or cisplatin and erythropoietin in pretreated patients with in field relapse after radiation therapy of non-small cell lung ...
Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. Am J Surg Pathol. 1998 ... Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases. Lung Cancer. 2006;53:111-115 ... Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study. Ann Thorac Surg. 2004;77:1163 ... Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced ...
... in a large phase III clinical trial and was approved in patients who failed first-line therapy. This drug has been available in ... Axitinib has shown activity in metastatic renal cell carcinoma (mRCC) ... Real world prospective experience of axitinib in metastatic renal cell carcinoma in a large comprehensive cancer centre. May 26 ... Axitinib has shown activity in metastatic renal cell carcinoma (mRCC) in a large phase III clinical trial and was approved in ...
Large Cell Lung Carcinoma Active Not Recruiting Phase 1 / 2 Trials for Paclitaxel (DB01229). Back to Large Cell Lung Carcinoma ... Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer ...
Should large cell neuroendocrine lung carcinoma be classified and treated as a small cell lung cancer or with other large cell ... Identity, similarity, and difference between large cell neuroendocrine carcinoma and small cell carcinoma. [J Thorac Oncol. ... with those of patients with small cell lung cancer (SCLC) or other large cell carcinomas (OLCs) and to compare overall survival ... Pulmonary large cell neuroendocrine carcinoma: a true high-grade neuroendocrine tumor needing prospective therapeutic data. [J ...
2010). Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral ... Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral ... Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral ...
Xie S, Liu W, Xiang Y, Dai Y, Ren J. Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma ... A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid ... Immunohistochemical characterization of diffuse large B-cell lymphoma (panels FJ). Panel A: Moderate amount of lymphocytes, ... Diffuse large B-cell lymphoma (DLBLC), Stage 1A (H&E, total magnification x200). Panel E: Hashimotos thyroiditis associated ...
Large cell neuroendocrine lung carcinoma (LCNEC) is a rare, highly malignant neoplasm. In the light of increasing incidence of ... Large cell neuroendocrine lung carcinoma (LCNEC) is a rare, highly malignant neoplasm. In the light of increasing incidence of ... Klotho expression and nodal involvement as predictive factors for large cell lung carcinoma. Barbara Brominska ... Klotho expression and nodal involvement as predictive factors for large cell lung carcinoma. Archives of Medical Science. 2019; ...
Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are. ... Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are ... Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are ... Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are ...
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma in China. The research was jointly conducted ... 22, 2019 /PRNewswire/ -- The world-class journal Cell, an international high-impact journal, published the article ... OrigiMed: The largest cohort study on HBV-Related hepatocellular carcinoma in China released in Cell ... news-releases/origimed-the-largest-cohort-study-on-hbv-related-hepatocellular-carcinoma-in-china-released-in-cell-300942829. ...
  • CEA stained 33% and 60% of the small and large cell carcinomas, respectively, most adenocarcinomas, and 84% of the squamous cell carcinomas, among which staining decreased with dedifferentiation and was often focal. (lu.se)
  • From 1976 to 2002, we identified 1062 cases of lung cancer: squamous cell (n 201), small cell (n 236), adenocarcinoma (n 543) and large cell carcinoma (n 82), among 65 560 current or former smokers. (bmj.com)
  • Risk reduction after quitting ranged from an 8 reduction (relative risk (RR): 0.92, 95 CI 0.91 to 0.94) to a 17 reduction (RR: 0.83, 95 CI 0.80 to 0.86) per year for adenocarcinoma and small cell carcinoma, respectively, with a 9 reduction observed for large cell carcinoma and an 11 reduction observed for squamous cell carcinoma. (bmj.com)
  • The risk of adenocarcinoma increased by 6 per year of smoking, compared to 7 for large cell, 10 for squamous cell and 12 for small cell. (bmj.com)
  • The 6 difference between adenocarcinoma and small cell carcinoma is equivalent to a 3.2 to 9.7-fold increase in risk for 20 years of smoking. (bmj.com)
  • All cytokeratins (CAM 5.2, PKK-1, AE1/AE3) reacted with virtually all adenocarcinomas, most squamous, and 65% of the large cell carcinomas, while CAM 5.2 was most efficient with the small cell carcinomas. (lu.se)
  • Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). (lu.se)
  • article{cf0dde2a-1de1-4aeb-9f7b-5f410161f5f1, abstract = {Lung carcinomas were studied immunohistochemically and the results were related to type of tissue sample (bronchoscopic biopsies, surgical specimens, autopsies). (lu.se)
  • It's a subtype of non-small cell lung cancer, the most common type of lung cancer. (facty.com)
  • Moreover, CEA negativity in several poorly differentiated lung carcinomas might have implications in the differential diagnosis against pleural mesothelioma. (lu.se)
  • Typically occurring in lung cancer, the cells are known for their large, rounded shape when seen under a microscope. (cancertreatments.co.nz)
  • The tumors associated with this type of cancer are also typically large. (facty.com)
  • Biopsies are usually performed to confirm the presence of cancerous cells in the tissues. (facty.com)
  • Large cell carcinoma is responsible for about ten percent of the non-small cell lung cancer diagnosis. (facty.com)
  • Non-small cell lung cancer is classified into four stages of its life cycle. (facty.com)
  • Non-small cell lung cancer survival rates are based on a five-year survival scale conducted from studies of people with this type of cancer. (facty.com)
  • The term large cell refers to the appearance of the cancer cells when viewed under a microscope. (facty.com)
  • Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to SCLC. (redorbit.com)
  • Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. (hindawi.com)
  • Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). (hindawi.com)
  • In recent years, large cell neuroendocrine carcinomas (LCNEC) that differ in cell morphology compared with small cell carcinoma have been occasionally reported [ 1 ]. (hindawi.com)
  • Tissue analysis revealed adenocarcinoma, so he was diagnosed with primary bladder cancer (LCNEC and urothelial carcinoma) and primary lung cancer (adenocarcinoma). (hindawi.com)
  • LCNEC is one group of neuroendocrine carcinomas in the lungs and bronchial tubes that was first reported by Travis et al. (hindawi.com)
  • Histological characteristics of LCNEC include the following: (1) growth patterns such as organoid, trabecular, and rosette, (2) large polymorphic tumor cells, low N/C ratio, and crude chromatin with obvious nucleolus, (3) high rate of mitosis, (4) necrosis, and (5) neuroendocrine tumor characteristics present in immunohistology and electron microscopy. (hindawi.com)
  • This is a Phase 1a/1b study of SC-002 in patients with relapsed small cell lung cancer (SCLC) or large cell neuroendocrine carcinoma (LCNEC). (clinicaltrials.gov)
  • Part 1A is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with cytologically confirmed, limited or extensive SCLC or LCNEC that have relapsed or refractory limited or extensive disease following no more than 2 prior chemotherapy regimens. (clinicaltrials.gov)
  • Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. (aacrjournals.org)
  • We performed targeted capture sequencing of all the coding exons of 244 cancer-related genes on 78 LCNEC samples [65 surgically resected cases, including 10 LCNECs combined with non-small cell lung cancer (NSCLC) types analyzed separately, and biopsies of 13 advanced cases]. (aacrjournals.org)
  • Large-cell neuroendocrine carcinoma (LCNEC) of the lung, which has been histologically categorized as high-grade neuroendocrine carcinoma with small-cell lung cancer (SCLC), is a highly malignant tumor with a poor prognosis. (aacrjournals.org)
  • Previous genomic studies have identified two mutually exclusive molecular subtypes of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly comutated with TP53 ) and the RB1 wild-type groups. (aacrjournals.org)
  • This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. (jcancer.org)
  • We herein report a case of prostatic metastasis of pulmonary large cell neuroendocrine carcinoma (LCNEC). (jcancer.org)
  • Large cell neuroendocrine lung carcinoma (LCNEC) is a rare, highly malignant neoplasm. (termedia.pl)
  • 1] on the efficacy of different chemotherapeutic regimens in a large series of 128 patients with stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung. (ersjournals.com)
  • In 2015, large cell neuroendocrine carcinoma (LCNEC) was removed from the large cell carcinoma group and classified with small cell lung carcinoma (SCLC) constituting two members of the high-grade neuroendocrine tumors (NETs) of the lung. (jcancer.org)
  • To the best of our knowledge, this study involved the largest number of high-grade LCNEC patients to date, with respect to a comparison between high-grade LCNEC and high-grade SCLC patients. (jcancer.org)
  • In our centre, we diagnose a case of Large-Cell Neuroendocrine Carcinoma (LCNEC) of the, endometrium in an 82 y old female. (alliedacademies.org)
  • Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. (biomedcentral.com)
  • LCNEC of the gallbladder is thought to be extremely rare and is usually found in combination with other histological carcinoma types, such as adenocarcinoma, as determined histologically. (biomedcentral.com)
  • Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? (maastrichtuniversity.nl)
  • BACKGROUNDS Large cell neuroendocrine carcinoma (LCNEC) is well-known as a lung cancer subtype. (semanticscholar.org)
  • Introduction: To treat LCNEC with non-small cell lung carcinoma type chemotherapy (NSCLC-ct, i.e. gemcitabine/taxanes or pemetrexed) or small cell lung carcinoma type (SCLC-ct, i.e. platinumetoposide) is subject of debate. (nrs-science.nl)
  • However, acquired resistance due to histological transformation into a large cell neuroendocrine carcinoma (LCNEC) is uncommon. (kjim.org)
  • A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid HT. (scielo.br)
  • Conversely, primary thyroid lymphoma (PTL) is a rare disease that accounts for 5% of all thyroid tumors: in 70% of cases it appears as diffuse large B-cell lymphoma (DLBCL), which usually presents with a more aggressive course and has a worse outcome. (scielo.br)
  • Diffuse large B cell lymphoma (DLBCL) is one of the most common acquired immune deficiency syndrome (AIDS)-defining malignancies among human immunodeficiency virus-infected patients, and rectal cancer has recently emerged as a prevalent non-AIDS-defining malignancy. (bvsalud.org)
  • The two biopsies revealed squamous cell carcinoma and diffuse large B-cell lymphoma (DLBCL), respectively. (ekjm.org)
  • More than 99% of primary lung cancers are carcinoma, which are tumors composed of cells that originate from embryonic ectoderm or endoderm, or that feature epithelial characteristics or differentiation. (wikipedia.org)
  • Vimentin, an intermediate filament protein usually associated with non-carcinomatous tumors (i.e. sarcoma), is ubiquitous in rhabdoid cells. (wikipedia.org)
  • Research presented in the July 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were treated with perioperative chemotherapy and surgery had better overall survival outcomes than patients treated with surgery alone. (redorbit.com)
  • A few neuroendocrine tumors found in the gastrointestinal tract are made of fast-growing, poorly differentiated cancer cells, and respond to different treatments than those used for carcinoid tumors. (mskcc.org)
  • Whether dose escalation of large tumors may improve local control and colostomy-free survival remains an important question and is the subject of ongoing trials. (springer.com)
  • They are named for the appearance of large round cells when examined under the microscope, although the tumors themselves tend to be large as well when diagnosed. (verywellhealth.com)
  • Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, and its incidence has been increasing in the last few decades, with a large prevalence of small tumors ( 1 ). (scielo.br)
  • Wang J, Ye L, Cai H, Jin M. Comparative study of large cell neuroendocrine carcinoma and small cell lung carcinoma in high-grade neuroendocrine tumors of the lung: a large population-based study. (jcancer.org)
  • Large cell neuroendocrine carcinoma is defined as a variant form of large cell carcinoma, and is classified in the wide spectrum of primary neuroendocrine tumors together with small cell carcinoma (SCC) and atypical carcinoid tumor. (biomedcentral.com)
  • In these cases, the tumors are classified as combined small cell lung carcinoma (c-SCLC), [7] and are (usually) treated like "pure" SCLC. (wikipedia.org)
  • The tumors associated with this type of cancer are also typically large. (facty.com)
  • These tumors tend to grow rapidly and spread more quickly than other types of non-small cell lung cancers. (picmonic.com)
  • One of the characteristic features of anaplastic lymphoma kinase (ALK) + , anaplastic large cell lymphoma (ALK + ALCL) is the constitutive activation of signal transducers and activators of transcription-3 (STAT3), a defect believed to be important for the pathogenesis of these tumors. (nature.com)
  • The IL-22 receptor, a heterodimer composed of IL-22R1 and IL-10R2, was expressed in all ALK + ALCL cell lines and tumors examined. (nature.com)
  • A recent published study using large-scale microarray gene expression profiling also described the expression of IL-22 among ALK − and ALK + ALCL tumors and cell lines. (nature.com)
  • These tumors usually present as a large peripheral mass with prominent necrosis . (icnet.uk)
  • These tumors are referred to as anaplastic or undifferentiated carcinomas. (wikipedia.org)
  • Very rarely, tumors may contain individuals components resembling both carcinoma and true sarcoma , including carcinosarcoma and pulmonary blastoma . (wikipedia.org)
  • Neuroendocrine tumors are tumors that develop from the cells of the diffuse neuroendocrine system, such as the enterochromaffin (EC) cells. (encyclopedia.com)
  • These tumors are characterized by the presence of cells that possess secretory granules and have the ability to secrete neurohormones. (encyclopedia.com)
  • Neuroendocrine tumors therefore represent a large class of cancers that can occur wherever neuroendocrine cells are found throughout the body. (encyclopedia.com)
  • They are sometimes called carcinoid tumors, but it would be more accurate to consider these tumors as a sub-category of the larger family of neuroendocrine tumors. (encyclopedia.com)
  • Neuroendocrine tumors are also known as apudomas, or tumors that contain apud cells. (encyclopedia.com)
  • Because they can occur wherever neuroendocrine cells are found, neuroendocrine tumors come in a wide variety of types and have been classified according to their site of origin, usually either as digestive system , pancreatic or lung neuroendocrine tumors. (encyclopedia.com)
  • Midgut tumors are the most common variety and they include small and large intestine tumors. (encyclopedia.com)
  • Functionally active neuroendocrine tumors display specific symptoms, such as the excessive release of specific neurohormones from the tumor cell, as described above for pancreatic neuroendocrine tumors. (encyclopedia.com)
  • Grade 1 neuroendocrine carcinomas are also known as carcinoid tumors. (encyclopedia.com)
  • Grade 2 include tumors such as atypical carcinoid tumors, medullary thyroid carcinomas, and some pancreatic endocrine tumors. (encyclopedia.com)
  • The approval was based on data from KEYNOTE-057 ( NCT02625961 ), a multicenter, open-label, single-arm trial in 96 patients with BCG-unresponsive, high-risk, non-muscle invasive bladder cancer (NMIBC) with carcinoma in situ (CIS) with or without papillary tumors who are ineligible for or have elected not to undergo cystectomy. (yahoo.com)
  • Giant cell tumors include giant-cell tumor of bone and giant-cell tumor of the tendon sheath. (wikipedia.org)
  • Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. (redorbit.com)
  • Lung cancer is the major cause of cancer-related deaths worldwide [ 1 ] and is generally divided into small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) [ 2 ]. (mdpi.com)
  • Next-generation sequencing (NGS) for TP53, RB1, STK11, and KEAP1 genes, as well as IHC for RB1 and P16 was performed on 79 and 109 cases, respectively, and correlated with overall survival (OS) and progression-free survival (PFS), stratifying for non-small cell lung cancer type chemotherapy including platinum + gemcitabine or taxanes (NSCLC-GEM/TAX) and platinum-etoposide (SCLC-PE). (aacrjournals.org)
  • To compare the presenting and prognostic characteristics of patients with large cell neuroendocrine lung cancer (LCNELC) with those of patients with small cell lung cancer (SCLC) or other large cell carcinomas (OLCs) and to compare overall survival (OS) and lung cancer-specific survival (LCSS) rates for patients undergoing definitive resection without radiotherapy (S-NoRT). (nih.gov)
  • In our study, patients with metastatic disease treated either in an adjuvant setting or post-surgery with platinum/etoposide, a conventional regimen for small cell lung cancer (SCLC), showed a significant clinical benefit in terms of overall survival compared to patients treated with chemotherapeutic regimens used for non-small cell lung cancer (NSCLC). (ersjournals.com)
  • Non-small-cell lung carcinoma ( NSCLC ) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). (wikipedia.org)
  • LCLC is differentiated from small cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. (wikipedia.org)
  • NSCLC and small cell lung cancer (SCLC) differ in how the cells look under a microscope, their origin, how quickly they spread to other parts of the body, and how they are treated. (cancersupportcommunity.org)
  • Often has features of both small cell lung carcinoma (SCLC) and non-small cell lung cancer (NSCLC). (ronnyallan.net)
  • Methods: For this population based retrospective cohort study all diagnoses of stage IV ct treated high grade neuroendocrine carcinomas (NEC, not being SCLC) were retrieved from the Netherlands Cancer Registry and Pathology Registry (PALGA) (2003-2012). (nrs-science.nl)
  • Small cell lung cancer (SCLC) accounts for about 15% of all lung cancer cases. (medicalnewstoday.com)
  • Possible mechanisms of acquired or secondary resistance to erlotinib include second mutations in the EGFR gene such as T790M, activation of an alternative pathway including Met or HER2 amplification, histological transformation to small cell lung cancer (SCLC) and epithelial to mesenchymal transition [ 1 ]. (kjim.org)
  • A rare form of cancer, similar to SCLC in prognosis and treatment, except that the cancer cells are unusually large. (encyclopedia.com)
  • can be classified under two broad categories - small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). (tgdaily.com)
  • In comparison to other lung cancer pathologies, the diagnoses adenocarcinoma and small cell lung cancer (SCLC) were significantly associated to CDH1 LOH ( p = 0.001). (mdpi.com)
  • large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation. (thefreedictionary.com)
  • Large cell carcinomas of the lung showing evidence of neuroendocrine differentiation is a distinctive clinicopathologic disease and should not be classified with unspecified large cell anaplastic carcinomas of the lung. (histopathology-india.net)
  • A tumor of undifferentiated (anaplastic) cells of large size. (lookfordiagnosis.com)
  • Large cell carcinoma is often a diagnosis of exclusion and histology shows anaplastic cells and pleomorphic giant cells. (picmonic.com)
  • Large cell carcinoma tends to be a highly anaplastic undifferentiated tumor. (picmonic.com)
  • Anaplastic cells are poorly differentiated cells that lose their normal morphological characteristics. (picmonic.com)
  • Histologically, large cell carcinoma is characterized by large polygonal cells and anaplastic cells growing in solid nests. (picmonic.com)
  • Anaplastic lymphoma kinase (ALK) + anaplastic large cell lymphoma (ALK + ALCL) is defined as a subtype of T/null-cell non-Hodgkin's lymphoma characterized by the consistent expression of CD30. (nature.com)
  • There are a large number of rare subtypes of anaplastic, undifferentiated carcinoma. (wikipedia.org)
  • The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. (mskcc.org)
  • Pathological diagnosis revealed cancer cells with a poor endoplasmic reticulum and elliptical nuclei rich in chromatin with medullary solid growth patterns. (hindawi.com)
  • Deodhar KK, Kerkar RA, Suryawanshi P, Menon H, Menon S. Large cell neuroendocrine carcinoma of the endometrium: an extremely uncom