Carcinoma large cell. Medical search

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Tumors or cancer of the LUNG.

Tumors or cancer of the LIVER.

An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.

A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.

A malignant epithelial tumor with a glandular organization.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.

A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

A cell line derived from cultured tumor cells.

Anaplastic lymphoma of the skin which develops as a primary neoplasm expressing the CD30 ANTIGEN. It is characterized by solitary nodules or ulcerated tumors.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.

Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

Tumors or cancer of the SKIN.

A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)

Clinically benign, histologically malignant, recurrent cutaneous T-cell lymphoproliferative disorder characterized by an infiltration of large atypical cells surrounded by inflammatory cells. The atypical cells resemble REED-STERNBERG CELLS of HODGKIN DISEASE or the malignant cells of CUTANEOUS T-CELL LYMPHOMA. In some cases, lymphomatoid papulosis progresses to lymphomatous conditions including MYCOSIS FUNGOIDES; HODGKIN DISEASE; CUTANEOUS T-CELL LYMPHOMA; or ANAPLASTIC LARGE-CELL LYMPHOMA.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)

A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tumors or cancer of the NASOPHARYNX.

DNA present in neoplastic tissue.

Tumors or cancer of the THYROID GLAND.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Tumors or cancer of the human BREAST.

Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

Malignant lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, one or more prominent nucleoli, and abundant cytoplasm. This class may be subdivided into plasmacytoid and clear-cell types based on cytoplasmic characteristics. A third category, pleomorphous, may be analogous to some of the peripheral T-cell lymphomas (LYMPHOMA, T-CELL, PERIPHERAL) recorded in both the United States and Japan.

A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)

A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.

A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.

A general term for various neoplastic diseases of the lymphoid tissue.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.

One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).

A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)

Tumors or cancer of the ESOPHAGUS.

Tumors or cancer of the MOUTH.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)

Tumors or cancer of the BRONCHI.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.

A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Experimental transplantation of neoplasms in laboratory animals for research purposes.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

Tumors or cancer of the STOMACH.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.

Tumors or cancer of the COLON.

A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)

A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.

A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.

Antibodies produced by a single clone of cells.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Tumors or cancer of the URINARY BLADDER.

Neoplasms composed of more than one type of neoplastic tissue.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Large cells, usually multinucleate, whose presence is a common histologic characteristic of classical HODGKIN DISEASE.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.

RNA present in neoplastic tissue.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

Tumors or cancer of the UTERINE CERVIX.

A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Loss of structural differentiation and useful function of neoplastic cells.

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Elements of limited time intervals, contributing to particular results or situations.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)

An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Transplantation between animals of different species.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.

Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.

A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.

The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.

Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.

Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)

Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.

Tumors or cancer of the gallbladder.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.

An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

A DNA-binding protein that represses GENETIC TRANSCRIPTION of target genes by recruiting HISTONE DEACETYLASES. Aberrant Blc-6 expression is associated with certain types of human B-CELL LYMPHOMA.

The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.

Tumors or cancer of the TONGUE.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Established cell cultures that have the potential to propagate indefinitely.

A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.

The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

Tumors or cancer of the SALIVARY GLANDS.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.

A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including BURKITT LYMPHOMA; IMMUNOBLASTIC LARGE-CELL LYMPHOMA; PRIMARY EFFUSION LYMPHOMA; and DIFFUSE, LARGE B-CELL, LYMPHOMA. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

Tumors or cancer of the NOSE.

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.

The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.

Biochemical identification of mutational changes in a nucleotide sequence.

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

The quantity of volume or surface area of CELLS.

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.

Mapping of the KARYOTYPE of a cell.

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

The degree of replication of the chromosome set in the karyotype.

Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

An expression of the number of mitoses found in a stated number of cells.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

An antineoplastic agent derived from BLEOMYCIN.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.

A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)

The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.

A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).

Using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis.

Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.

Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.

Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. (1/382)

The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in various tumor cell lines including human non-small cell lung carcinoma (NSCLC) cells, which are resistant to the natural all-trans retinoic acid and to many synthetic receptor-selective retinoids. Although the mechanism of this effect was not elucidated, it was found to be independent of nuclear retinoid receptors. In the present study, we analysed the mechanisms by which CD437 induces apoptosis in two human NSCLC cell lines: H460 with wild-type p53 and H1792 with mutant p53. Both cell lines underwent apoptosis after exposure to CD437, although the cell line with wild-type p53 (H460) was more sensitive to the induction of apoptosis. CD437 increased the activity of caspase in both cell lines, however, the effect was much more pronounced in the H460 cells. The caspase inhibitors (Z-DEVD-FMK and Z-VAD-FMK) suppressed CD437-induced CPP32-like caspase activation and apoptosis in both cell lines. CD437 induced the expression of the p53 gene and its target genes, p21, Bax, and Killer/DR5, only in the H460 cells. These results suggest that CD437-induced apoptosis is more extensive in NSCLC cells that express wild-type p53, possibly due to the involvement of the p53 regulated genes Killer/DR5, and Bax although CD437 can also induce apoptosis by means of a p53-independent mechanism. Both pathways of CD437-induced apoptosis appear to involve activation of CPP32-like caspase. (+info)

A case of synchronous double primary lung cancer with neuroendocrine features. (2/382)

We report a case of unique double primary lung cancers with neuroendocrine features in a 63-year-old male smoker. The mass in the left lower lobe (LLL) was a small cell/large cell carcinoma with spindle cell sarcomatous areas and organoid structure. The mass in the left upper lobe (LUL) was a tubular adenocarcinoma with neuroendocrine features including organoid nests showing occasional rosette formation, nuclear palisading in the periphery of the nests and positive immunoreaction for CD56, chromogranin A and synaptophysin. The difference in histological structures between the two masses led us to diagnose double primary lung cancer. The combination of small cell lung carcinoma and spindle cell carcinoma is very uncommon. The relationship between LLL and LUL tumors remains unclear. Multiple lung cancers with neuroendocrine features have only rarely been reported in the literature. The patient in our case died of widespread cancer 2 years and 4 months after the surgery without adjuvant chemotherapy, a longer postoperative survival time than in cases of ordinary extensive small cell lung cancer. Multiple lung cancers with neuroendocrine features are extremely rare and similar cases have not been reported in the literature. Neuroendocrine differentiation has attracted widespread attention and, therefore, examining neuroendocrine features in lung cancers is important. (+info)

Lung cancer incidence rates by histologic type in high- and low-risk areas; a population-based study in Osaka, Okinawa, and Saku Nagano, Japan. (3/382)

We investigated lung cancer incidence by histologic type using the data from population-based cancer registries in high-risk (Osaka and Okinawa) and low-risk (Saku Nagano) areas. Since the proportion of cases with histologic types identified was not sufficiently high, sex- and age-specific incidence rates by histologic type were estimated assuming that the distribution of histologic types was the same across the same sex and age groups regardless of reporting status. Compared to Saku in Nagano Prefecture, the cumulative risk of lung cancer incidence rates in Osaka and Okinawa were 1.3 and 1.5 times higher for males and 1.3 and 1.2 times higher for females, respectively. When divided by histologic type, male adenocarcinoma and small cell carcinoma were 1.6-2.1 times higher in Osaka and Okinawa, while squamous cell carcinoma was 1.6 times higher only in Okinawa compared to Saku Nagano. In females, squamous cell carcinoma and small cell carcinoma were 2.5-3.3 times higher in Osaka and Okinawa compared to Saku Nagano, while adenocarcinoma was almost equal in the 3 areas. These results indicate that the pattern of incidence of lung cancer by histologic type may differ between high- and low- risk areas. (+info)

Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. (4/382)

Poly(ADP-ribose) polymerase (PADPRP) is a nuclear DNA-binding enzyme that can modulate chromatin structure close to DNA replication, recombination and repair regions. Two-allele polymorphism on the PADPRP chromosome 13 pseudogene has been studied in several ethnic subpopulations, and the association of each allele with different types of cancer has been investigated. To study the frequency of the allele in the context of lung cancer, we performed a PCR assay for the PADPRP polymorphism in 288 lung cancer patients and 292 matched controls and examined the frequency of the alleles in different ethnic groups. Our results showed that the allele distribution was significantly different among members of different ethnic groups. Specifically, the A allele was dominant in Mexican-American and Caucasian groups but not in the African-American group. The frequencies of the B allele in Mexican-American, Caucasian and African-American controls were 0.184, 0.218 and 0.606, respectively, with the Caucasian cases and controls showing an almost identical lower B allele frequency (0.199 in cases versus 0.218 in controls), and the African-American cases and controls showing an almost identical but considerably higher frequency (0.578 in cases versus 0. 606 in controls). In contrast, the Mexican-American cases and controls exhibited a considerable difference in the B allele frequency (0.306 in cases versus 0.184 in controls). When we combined subjects with the AB or BB genotype into a susceptible genotype group and compared them with the AA group using univariate analysis, the susceptible genotype was not shown to be associated with a risk of lung cancer in either the Caucasian or African-American subpopulation but was significantly associated with an increased risk (2.29-fold) of lung cancer in the Mexican-American group. When lung cancer was categorized by histologic type, no elevated risk was noted for squamous cell carcinoma in any ethnicity. However, in Mexican-Americans, susceptible genotypes were associated with significantly increased risks of adenocarcinoma (3. 21-fold) and large cell carcinoma (10.79). Our study and others have demonstrated that the PADPRP polymorphism may modify an individual's susceptibility to certain cancers. Assessment of the interaction between genetic constitution and environmental exposure might expand our understanding of carcinogenesis and enhance our ability to evaluate the populational cancer risk. (+info)

p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer. (5/382)

The oncogene product epidermal growth factor receptor (EGF-R), the tumour suppressor gene product p53 and anti-p53 antibodies are detectable in the serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure and after exposure to polycyclic aromatic hydrocarbons or vinylchloride. In the first step, this study investigated the possible diagnostic value of serum EGF-R, p53-protein and anti-p53 antibodies, measured by an enzyme-linked immunosorbent assay, in lung tumour patients. In addition to being investigated on a molecular epidemiological basis, these parameters were examined as biomarkers of carcinogenesis, especially with regard to asbestos incorporation effects or of radon-induced lung cancers. Also, a possible effect of cigarette smoking and age dependence were studied. A total of 116 male patients with lung or pleural tumours were examined. The histological classification was four small-cell cancers, six large-cell cancers, 32 adenocarcinomas, 47 squamous carcinomas, 12 mixed lung carcinomas, five diffuse malignant mesotheliomas and ten lung metastasis of extrapulmonary tumours. Twenty-two lung cancers and all mesotheliomas were related to asbestos, 22 lung cancers were related to ionizing radiation and 61 patients had cigarette smoke-related lung cancer. Besides these patients 50 male patients with non-malignant lung or pleural diseases were included; of the latter eight subjects suffered from asbestosis. Controls were 129 male subjects without any lung disease. No significantly elevated or decreased serum values for p53 protein, EGF-R, or anti-p53 antibodies as a function of histological tumour type, age, or degree and type of exposure (asbestos, smoking, ionizing radiation) could be found. The utility of p53-protein, EGF-R and anti-p53 antibodies as routine biomarkers for screening occupationally derived lung cancers is limited. (+info)

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53. (6/382)

Recent investigations have revealed that mutations of the loop-sheet-helix motif of p53 is a significant factor for a poor prognosis in patients with non-small-cell lung cancer (NSCLC). To clarify this mechanism, bcl-2 and bax expression were evaluated in relation to mutations of p53. Tumor tissues of 203 patients with NSCLC were analyzed. Immunohistochemistry was performed to evaluate bcl-2 and bax expression, and polymerase chain reaction single-strand conformation polymorphism following direct sequencing was performed to investigate p53 status. A total of 79 carcinomas were bcl-2 positive, 146 carcinomas were bax positive, and 72 carcinomas had missense mutations of p53. There was no difference in bcl-2 expression in relation to p53 status. On the other hand, tumors with structural mutations of p53 had significantly lower expression of bax than those with wild-type p53 (P = 0.0026). In contrast, tumors with mutations of the loop-sheet-helix motif of p53 had significantly higher expression of bax than those with wild-type p53 (P = 0.0236). The frequency of a bcl-2/bax ratio of >/=1 was significantly lower in tumors with mutations of the loop-sheet-helix motif than that in tumors with wild-type p53 (P = 0.0240). The bcl-2/bax ratio status was a significant factor for a prognosis in patients with NSCLC (P = 0.0083). Mutations of the loop-sheet-helix motif of p53 were correlated with overexpression of bax, while other mutations of p53 were correlated with low levels of bax expression. This variation in pattern of bax expression in relation to mutant p53 might reflect the biological behavior of tumors in patients with bcl-2-positive NSCLC. (+info)

k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. (7/382)

Environmental carcinogen exposure is requisite for the development of nearly all lung cancer, and it is well known that asbestos exposure interacts synergistically with tobacco smoke to induce lung cancer. However, the precise molecular lesions induced by asbestos are unknown. Furthermore, it is also unknown whether asbestos carcinogenesis proceeds in a fashion independent of or dependent upon the induction of fibrosis in workers with high asbestos exposures. Previous studies have suggested that asbestos is associated with the presence of a k-ras mutation in adenocarcinoma of the lung. We aimed to test whether occupational asbestos exposure was associated with k-ras codon 12 mutations in lung adenocarcinoma tumors and to determine whether this was conditional on the presence of asbestosis. All newly diagnosed, resectable lung cancer patients receiving treatment at the Massachusetts General Hospital between November 1992 and December 1996 were eligible to participate. Because k-ras mutation is very strongly associated with adenocarcinoma, and men were more likely to be occupationally exposed to asbestos, the study was restricted to males with this histological diagnosis. There were 84 male patients with available questionnaire-derived work history data and paraffin-embedded tumor tissue for determination of k-ras mutation status. Chest radiographic evaluation was done for all of the patients who reported occupational exposure to asbestos. The prevalence of k-ras mutation was higher among those with a history of occupational asbestos exposure (crude odds ratio, 4.8; 95% confidence interval, 1.5-15.4) compared to those without asbestos exposure, and this association remained after adjustment for age and pack-years smoked (adjusted odds ratio, 6.9; 95% confidence interval, 1.7-28.6). An index score that weights both the dates of exposure and the estimated intensity of exposure indicated that those with k-ras mutations had significantly greater asbestos exposures than those without mutations (P < 0.01). Analysis of the descriptive components of exposure indicated that the duration of exposure was not associated with k-ras mutation, but that the time since initial exposure was significantly associated with mutation status. The association of k-ras mutation and reported asbestos exposure was not dependent on the presence of radiographic evidence of asbestos-related disease. These data suggest that asbestos exposure increases the likelihood of mutation at k-ras codon 12 and that this process occurs independently of the induction of interstitial fibrosis. (+info)

Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. (8/382)

BACKGROUND: Several molecular changes, including loss of heterozygosity (i.e., deletion of one copy of allelic DNA sequences) and alterations in microsatellite DNA, have been detected early in the pathogenesis of lung cancer, even in histologically normal epithelium. In the bronchial epithelium of patients with lung cancer, we have determined the frequency, size, and patterns of molecularly abnormal clonal patches. METHODS: We studied formalin-fixed, paraffin-embedded samples from 16 surgically resected lung carcinomas (five squamous cell carcinomas, four small-cell carcinomas, six adenocarcinomas, and one large-cell carcinoma). From each carcinoma, we microdissected foci (each containing about 200 cells) of tumor tissue and equivalent samples of histologically normal and abnormal epithelium. Furthermore, multiple discontinuous foci of bronchial epithelium were analyzed from methanol-fixed samples from three additional patients with lung cancer (two with squamous cell carcinoma and one with adenocarcinoma). We used two-step polymerase chain reaction-based assays involving 12 microsatellite markers at seven chromosomal regions frequently deleted in lung cancer. RESULTS: Two hundred eighteen foci of nonmalignant bronchial epithelium (195 of histologically normal or slightly abnormal epithelium and 23 of dysplastic epithelium) were studied from the 19 surgically resected lobectomy specimens. Thirteen (68%) of the 19 specimens had at least one focus of bronchial epithelium with molecular changes. At least one molecular abnormality was detected in 32% of the 195 histologically normal or slightly abnormal foci and in 52% of the 23 dysplastic foci. Extrapolating from our two-dimensional analyses, we estimate that most clonal patches contain approximately 90 000 cells. Although, in a given individual, tumors appeared homogeneous with respect to molecular changes, the clonally altered patches of mildly abnormal epithelium were heterogeneous. CONCLUSIONS: Our findings indicate that multiple small clonal or subclonal patches containing molecular abnormalities are present in normal or slightly abnormal bronchial epithelium of patients with lung cancer. (+info)

Tocilizumab was first used in large-cell lung carcinoma. In phase I/II trial of tocilizumab in ovarian cancer EGFR pathway ... However, it has become evident that eccentric exercises are not associated with a larger increase in plasma IL-6 than exercise ... of patients with metastatic castration-associated prostate cancer in combination with docetaxel and in renal cell carcinoma; ...

https://en.wikipedia.org/wiki/Anti-IL-6

... small-cell lung cancer (SCLC) large cell neuroendocrine carcinoma of the lung (LCNEC) Extrapulmonary small cell carcinomas ( ... neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. Additionally, the WHO scheme ... "Large cell carcinoma of the lung with neuroendocrine differentiation. A comparison with large cell "undifferentiated" pulmonary ... mixed exocrine-neuroendocrine carcinoma (goblet cell carcinoma, also called adenocarcinoid and mucous adenocarcinoid) Hindgut ...

https://en.wikipedia.org/wiki/Neuroendocrine_tumor

ISBN 978-0-7216-0187-8. Mulvany NJ, Allen DG (January 2008). "Combined large cell neuroendocrine and endometrioid carcinoma of ... Endometrioid carcinoma can also arise in the endometrium. Grades 1 and 2 are considered "type 1" endometrial cancer, while ... Carcinoma,+Endometrioid at the US National Library of Medicine Medical Subject Headings (MeSH) "ACS :: What Is Endometrial ... Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third ...

https://en.wikipedia.org/wiki/Endometrioid_tumor

... producing large pools of mucus/colloid (optically "empty" spaces). It is poorly differentiated. In signet-ring cell carcinomas ... These may include extranodal marginal zone B-cell lymphomas (MALT type) and to a lesser extent diffuse large B-cell lymphomas. ... Gastric signet ring cell carcinoma. H&E stain. Adenocarcinoma of the stomach and intestinal metaplasia. H&E stain. If cancer ... the mucus remains inside the tumour cell and pushes the nucleus to the periphery, giving rise to signet-ring cells. Around 5% ...

https://en.wikipedia.org/wiki/Stomach_cancer

They are susceptible to induced squamous cell carcinoma. They have large litter sizes, and their oocytes possess prominent ...

https://en.wikipedia.org/wiki/FVB_mouse

... of lung cancers are large-cell carcinoma. These are so named because the cancer cells are large, with excess cytoplasm, large ... The three main subtypes of NSCLC are adenocarcinoma, squamous-cell carcinoma, and large-cell carcinoma. Rare subtypes include ... Small-cell lung carcinoma may originate from these cell lines or neuroendocrine cells, and it may express CD44. Metastasis of ... The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are ...

https://en.wikipedia.org/wiki/Lung_cancer

"Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". Journal of Immunology. 169 ... This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, ... "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the ... Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( ...

https://en.wikipedia.org/wiki/LGTN

In 1879, Arnold examined sarcoma and carcinoma cells having very large nuclei. Today, the study of molecular cytogenetics can ... Removing the cell culture and isolation step dramatically simplifies and expedites the process. Using similar principles to CGH ... Cancer cells often accumulate complex chromosomal structural changes such as loss, duplication, inversion or movement of a ... FISH allows one to visualize different parts of the chromosome at different stages of the cell cycle. FISH can either be ...

https://en.wikipedia.org/wiki/Molecular_cytogenetics

"Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the ... Chromosomal translocation of BRD3 with the NUT gene has been implicated in NUT midline carcinoma. BRD3-NUT driven cancers are ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. v t e. ... The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA ...

https://en.wikipedia.org/wiki/Bromodomain-containing_protein_3

1994). "A large cell-adhesive scatter factor secreted by human gastric carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 90 (24 ... 2000). "Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas". Biochem. ... It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in ... 1997). "Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by ...

https://en.wikipedia.org/wiki/Laminin,_gamma_2

The rate of incidence varies from 0.5 to 4%. Cytologically, the cells of apocrine carcinoma are relatively large, granular, and ... When apocrine carcinoma is tested as a "triple negative", it means that the cells of the patient cannot express the estrogen ... The apical portion of the secretory cell of the gland pinches off and enters the lumen. It loses part of its cytoplasm in their ... Cells which are classified as apocrine bud their secretions off through the plasma membrane producing extracellular membrane- ...

https://en.wikipedia.org/wiki/Apocrine

"High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma". The Biochemical ... The SAT1 gene is used to help regulate polymamies levels inside the cell by regulating their transport in and out of the cell. ... regulates cell growth and metastasis via AKT/β-catenin signaling pathways in hepatocellular and colorectal carcinoma cells". ... October 2017). "Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease". Cell. 171 (2): 273- ...

https://en.wikipedia.org/wiki/SAT1_(gene)

high grade neuroendocrine carcinoma, ICD-O 8246/3) *z dużych komórek (ang. large cell neuroendocrine carcinoma, ICD-O 8013/3) ... squamous cell carcinoma, ICD-O 8070/3). *rak z limfoidnym podścieliskiem (rdzeniasty) (ang. carcinoma with lymphoid stroma ( ... signet ring cell carcinoma and other variants; poorly cohesive carcinoma, ICD-O 8490/3) ... Signet ring cell carcinoma of the stomach is significantly associated with poor prognosis and diffuse gastric cancer (Lauren's ...

https://pl.wikipedia.org/wiki/Rak_żołądka_człowieka

This may lead to mutations or large genome abnormalities, which can threaten the cell or organism's ability to live. Several ... Mismatch repair defects, for example, cause instability that predisposes to colorectal and endometrial carcinomas. DNA lesions ... However, these drugs can not tell the difference between sick and healthy cells, resulting in the damage of normal cells. ... If the damage is not too extensive, precancerous or cancerous cells are created from healthy cells. Chemotherapeutics, by ...

https://en.wikipedia.org/wiki/Molecular_lesion

A few days later, he was diagnosed with large-cell carcinoma of the lung, typically associated with smoking. After audiences ...

https://en.wikipedia.org/wiki/Andy_Kaufman

... is characterised by Paget cells. Paget cells are large cells with clear cytoplasm (clear halo) ... ductal carcinoma in situ cells migrate into the lactiferous sinuses and the nipple skin. Cancer cells disrupt the normal ... who distinguishes Paget cells from other cell types by staining tissues to identify specific cells (immunohistochemistry). ... There is some controversy as to whether these cells arise from the ductal system of the breast, or whether these cells are a ...

https://en.wikipedia.org/wiki/Paget's_disease_of_the_breast

May 16, 1984: Actor and entertainer Andy Kaufman died from kidney failure that was related to Large-cell lung carcinoma. ... Nine large-scale works are located in courtyards, parking lots and public walkways throughout the approximately 30-acre campus ... Cedars of Lebanon Hospital could accommodate 279 patients and was large and comprehensive, with all of the components of a ... Aushenker, Michael (October 3, 2002). "From TB to T-Cell, Tracing the Roots of Cedars-Sinai". The Jewish Journal. Retrieved ...

https://en.wikipedia.org/wiki/Cedars-Sinai_Medical_Center

... and large superficial basal cell carcinoma. Ten adverse events were associated with cupping. The minor ones were keloid ... Most such reports originate from Asia, which may reflect the large number of treatments performed there or a relatively higher ... a 2016 review found that most published trials of the technique were of poor value due to methodology issues and larger trials ... the evidence was not conclusive due to the lack of large, high-quality trials. A 2014 overview of systematic reviews found ...

https://en.wikipedia.org/wiki/Acupuncture

Squamous cell carcinoma, melanoma in situ, Pagetoid Bowen's disease, ocular sebaceous carcinoma, and other carcinomas can all ... wherein the large tumour cells are arranged singly or in small clusters within the epidermis and its appendages. These cells ... This proliferation of cells in the epidermis is responsible for the "buckshot scatter" pattern. This is a typical feature of ... Pagetoid is a term used in dermatology to refer to "upward spreading" of abnormal cells in the epidermis (ie from bottom to top ...

https://en.wikipedia.org/wiki/Pagetoid

... while squamous cell carcinomas and large cell carcinomas are rarely positive. Small cell carcinomas (of any primary site) are ... large cell carcinomas, small-cell lung carcinomas, neuroendocrine tumors other than small-cell lung carcinomas and ... "TTF-1 and p63 for distinguishing pulmonary small-cell carcinoma from poorly differentiated squamous cell carcinoma in ... TTF-1 positive cells are found in the lung as type II pneumocytes and club cells. In the thyroid, follicular and parafollicular ...

https://en.wikipedia.org/wiki/NK2_homeobox_1

... up-regulated in human carcinomas and modulating cell replication and tumor growth". Am. J. Pathol. 149 (2): 493-500. PMC ... Guijarro MV, Castro ME, Romero L, Moneo V, Carnero A (2007). "Large scale genetic screen identifies MAP17 as protein bypassing ... "Interactions of MAP17 with the NaPi-IIa/PDZK1 protein complex in renal proximal tubular cells". Am. J. Physiol. Renal Physiol. ... a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733-45. doi:10.1046/j.1523-1755.2003.00266 ...

https://en.wikipedia.org/wiki/PDZK1IP1

"Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi: ... "Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin ... Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Kusz K, Ginter-Matuszewska B, Ziolkowska K ... "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ- ...

https://en.wikipedia.org/wiki/PUM2

The rate of incidence varies from 0.5 to 4%.[3] Cytologically, the cells of apocrine carcinoma are relatively large, granular, ... Apocrine carcinomaEdit. Apocrine carcinoma is a very rare form of female breast cancer. ... The apical portion of the secretory cell of the gland pinches off and enters the lumen. It loses part of its cytoplasm in their ... Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in the breast in the context ...

https://en.m.wikipedia.org/wiki/Apocrine

By establishing a human squamous carcinoma cell line, Kaziro and his team were able to produce large quantities of purified G- ... CSF is a hormone-like glycoprotein that assists in regulating the cell proliferation and differentiation of hematopoietic cells ... The team was able to determine a partial amino acid sequence of the protein and produced several clones within cells. This ... was the most potent and could be used as a tool for researchers to regulate the Ras and Raf-1 cell signaling pathways in cells ...

https://en.wikipedia.org/wiki/Yoshito_Kaziro

"Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas ... Later in development, CDX2 is expressed in intestinal epithelial stem cells, which are cells that continuously differentiate ... specifically marking the trophectoderm lineage of cells in the blastocyst of mouse and human. Trophectoderm cells contribute to ... "Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2". Nature Communications. 5 ...

https://en.wikipedia.org/wiki/CDX2

"ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of ... Anaplastic lymphoma kinase (ALK) was originally discovered in 1994 in anaplastic large-cell lymphoma (ALCL) cells. ALCL is ... January 2005). "Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma". ... November 2008). "The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 ...

https://en.wikipedia.org/wiki/Anaplastic_lymphoma_kinase

August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of ... As early as 1996, the over-expression of HAAH was recognized as an indicator of carcinoma in humans. Further research has ... May 2006). "Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness". Journal of Hepatology. 44 ... The Journal of Cell Biology. 166 (4): 537-48. doi:10.1083/jcb.200404079. PMC 1868564. PMID 15302852. Beausoleil SA, ...

https://en.wikipedia.org/wiki/ASPH

... is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus ... Lee SY, Park CG, Choi Y (Feb 1996). "T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic ... "Identification of Hodgkin and Sternberg-reed cells as a unique cell type derived from a newly-detected small-cell population". ... "FDA approves Brentuximab vedotin for the treatment of adult patients with primary cutaneous anaplastic large cell lymphoma". ...

https://en.wikipedia.org/wiki/CD30

... mitochondrial DNA large deletions, and nuclear microsatellite instability in head and neck squamous cell carcinomas". Diagn. ... but more mtDNA large scale deletions have been found in normal cells compared to tumor cells. This may be due to a seemingly ... not only cancer cells). Thus, drugs that knock out these oncogenes (and thereby kill cancer cells) may also damage normal cells ... If the knockout of an otherwise nonessential gene has little or no effect on healthy cells, but is lethal to cancerous cells ...

https://en.wikipedia.org/wiki/Oncogenomics

squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Large nodules were previously called cysts. The term nodulocystic has been used in the medical literature to describe severe ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ...

https://en.wikipedia.org/wiki/Acne_vulgaris

Oral carcinoma[edit]. Patients after HSCT are at a higher risk for oral carcinoma. Post-HSCT oral cancer may have more ... In the case of a bone marrow transplant, the HSC are removed from a large bone of the donor, typically the pelvis, through a ... who have lost their stem cells after birth. Other conditions[13] treated with stem cell transplants include sickle-cell disease ... Peripheral blood stem cells[26] are now the most common source of stem cells for HSCT. They are collected from the blood ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

Squamous cell carcinoma may occasionally develop, usually in chronic cases, and at the edge of ulcer.[citation needed] Tetanus ... Large infected ulcers may require debridement under anesthesia. Skin grafting may be helpful in advanced cases to ensure the ... Chronic ulcers involve larger area and may eventually develop into squamous epithelioma after 10 years or more. Skin color: ...

https://en.wikipedia.org/wiki/Tropical_ulcer

The removal of cells for biopsy, using a needle Clinical features[edit]. Clinical features can be found in the subhyoid portion ... Thyroglossal duct cyst carcinoma[edit]. Rarely, cancer may be present in a thyroglossal duct cyst. These tumors usually arise ... especially if the cyst becomes large. ... Thyroglossal duct carcinoma occurs in approximately 1 to 2% of ... Thyroglossal cysts can be defined as an irregular neck mass or a lump which develops from cells and tissues left over after the ...

https://en.wikipedia.org/wiki/Thyroglossal_cyst

Giant cells - considerably larger than their neighbors - may form and possess either one enormous nucleus or several nuclei ( ... Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ...

https://en.m.wikipedia.org/wiki/Brain_tumors

... or tumors such as lymphoma or squamous cell carcinoma. A tonsillolith (also known as a "tonsil stone") is material that ... However, they are largest relative to the diameter of the throat in young children. In adults, each palatine tonsil normally ... These M cells then alert the underlying B cells and T cells in the tonsil that a pathogen is present and an immune response is ... The tonsils have on their surface specialized antigen capture cells called M cells that allow for the uptake of antigens ...

https://en.wikipedia.org/wiki/Tonsil

BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ... Truswell, AS (Mar 2002). "Meat consumption and cancer of the large bowel". European Journal of Clinical Nutrition. 56 (Suppl 1 ... In the 18th century a scrotal cancer of chimney sweepers, the chimney sweeps' carcinoma, was already known to be connected to ... BaP has an effect on the number of white blood cells, inhibiting some of them from differentiating into macrophages, the body's ...

https://en.wikipedia.org/wiki/Benzo(a)pyrene

... cancer that begins in egg cells).. *Mucinous appendiceal carcinoma: A type of cancer that begins in cells that line the ... However, the surgical removal of large pleural deposits with infusion of hyperthermic chemotherapy may offer significant ... Most ovarian cancers are either ovarian epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or ... uterine and renal cell carcinoma among others ; as well as certain sarcomas and pseudomyxoma peritonei. ...

https://en.wikipedia.org/wiki/Intrathoracic_hyperthermic_perfused_chemotherapy_

Basal cell carcinoma Fleshy, growing mass Areas exposed to the sun Squamous cell carcinoma Unusual growth that is red, scaly or ... Started with a single scaly, red and slightly itchy spot, and within a few days, did large numbers of smaller patches of the ... Large red bumps that seem to bruise and are tender to touch Anywhere ... Small red dots on the skin, or larger, bruise-like spots that appeared after taking medicine Anywhere ...

https://en.wikipedia.org/wiki/Skin_rash

cell maturation. • Wnt signaling pathway. • embryonic camera-type eye development. • multicellular organism development. • cell ... Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family ... "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S. ... T cell differentiation in thymus. • chorionic trophoblast cell differentiation. • positive regulation of protein targeting to ...

https://en.wikipedia.org/wiki/FZD5

Glioblastomas are the most common primary malignancies to hemorrhage while thyroid, renal cell carcinoma, melanoma, and lung ... These arteries are the large blood vessels in your neck that feed your brain. Transcranial Doppler (TCD): Transcranial Doppler ... Hemorrhagic transformation of an ischemic infarct Cerebral venous thrombosis Sympathomimetic drug abuse Moyamoya Sickle cell ...

https://en.wikipedia.org/wiki/Intraparenchymal_hemorrhage

The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. ... Shimada S, Matsuzaki H, Marutsuka T, Shiomori K, Ogawa M (July 2001). "Gastric and intestinal phenotypes of gastric carcinoma ... In fact, 70% of dimeric phosphorylase in the cell exists as bound to glycogen granules rather than free floating.[9] ... Although the reaction is reversible in solution, within the cell the enzyme only works in the forward direction as shown below ...

https://en.wikipedia.org/wiki/Glycogen_phosphorylase

Large blue. A few hours to a few days Lymphocyte. 30%. Small lymphocytes 7-8. Large lymphocytes 12-15. *B cells: releases ... carcinoma ... T cells: *CD4+ helper T cells: T cells displaying co-receptor ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ... CD8+ cytotoxic T cells: T cells displaying co-receptor CD8 are known as CD8+ T cells. These cells bind antigens presented on ...

https://en.wikipedia.org/wiki/Immune_cell

"The expression of different superoxide dismutase forms is cell-type dependent in olive (Olea europaea L.) leaves". Plant & Cell ... Moreover, superoxide dismutase has the largest kcat/KM (an approximation of catalytic efficiency) of any known enzyme (~7 x 109 ... including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts ... The cytosols of virtually all eukaryotic cells contain an SOD enzyme with copper and zinc (Cu-Zn-SOD). For example, Cu-Zn-SOD ...

https://en.wikipedia.org/wiki/Orgotein

Although derived from a colon (large intestine) carcinoma, when cultured under specific conditions the cells become ... 1983). "Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture". Biol Cell. ... Caco-2 cells are most commonly used not as individual cells, but as a confluent monolayer on a cell culture insert filter (e.g ... 2005). "The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell ...

https://en.wikipedia.org/wiki/Caco-2

Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... which often form large amorphous aggregates in the cell, can be degraded directly by the 20S core particle without the 19S ... "Cell. 137 (1): 133-45. doi:10.1016/j.cell.2009.01.041. PMC 2668214. PMID 19345192.. ... Cell cycle controlEdit. Cell cycle progression is controlled by ordered action of cyclin-dependent kinases (CDKs), activated by ...

https://en.m.wikipedia.org/wiki/Proteasome

It is thought[citation needed] that all molds may produce mycotoxins and thus all molds may be potentially toxic if large ... This affects in the cells action potential profile, as seen in cardiomyocytes, pneumocytes and neurons leading to conduction ... "Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment". Environmental Health Perspectives. 118 (6): ... McCormick A, Loeffler J, Ebel F (November 2010). "Aspergillus fumigatus: contours of an opportunistic human pathogen". Cell. ...

https://en.m.wikipedia.org/wiki/Toxic_mold

A seminoma is a germ cell tumor of the testicle or, more rarely, the mediastinum or other extra-gonadal locations. It is a ... Large residual masses found after chemotherapy may require surgical resection. Second-line treatment is the same as for ... Embryonal carcinoma. *Endodermal sinus tumor/Yolk sac tumor. *Teratoma: Fetus in fetu ... Weidner N (February 1999). "Germ-cell tumors of the mediastinum". Seminars in Diagnostic Pathology. 16 (1): 42-50. PMID ...

https://en.wikipedia.org/wiki/Seminoma

... mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[5] Large amounts of TNF are released ... Treatment of renal cell carcinoma with infliximab resulted in prolonged disease stabilization in certain patients. Etanercept ... positive regulation of heterotypic cell-cell adhesion. • negative regulation of mitotic cell cycle. • endothelial cell ... NK cells, neutrophils, mast cells, eosinophils, and neurons.[5] TNFα is a member of the TNF superfamily, consisting of various ...

https://en.wikipedia.org/wiki/TNF-alpha

Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... 2005). "Cervix carcinoma". In Gerbaulet A, Pötter R, Mazeron J, Limbergen EV. The GEC ESTRO handbook of brachytherapy. Belgium ... Due to their relatively large mass, protons and other charged particles have little lateral side scatter in the tissue-the beam ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ...

https://en.wikipedia.org/wiki/Radiation_therapy

Virchow's cell, a macrophage in Hansen's disease. *Virchow's cell theory, omnis cellula e cellula - every living cell comes ... It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... From it, he coined a well known aphorism: "Medicine is a social science, and politics is nothing else but medicine on a large ... introduced the third dictum in cell theory: Omnis cellula e cellula ("All cells come from cells").[9] He was a co-founder of ...

https://en.m.wikipedia.org/wiki/Rudolf_Virchow

The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the ... squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... This often presents itself as a lump of tissue near the anus which grows larger and more painful with time. Like other ... The final structure of the abscess is an abscess wall, or capsule, that is formed by the adjacent healthy cells in an attempt ...

https://en.wikipedia.org/wiki/Abscess

Originally started a laryngeal carcinoma strain, the cell line was contaminated and displaced by HeLa cells, and has now been ... They are superior to the previously used animal tissues because of their large size and the high rate of mitosis (cell division ... T-cells and B-cells) and antigen presenting cells. These cells coordinate an immune response upon the detection of foreign ... Hargraves M, Richmond H, Morton R. Presentation of two bone marrow components, the tart cell and the LE cell. Mayo Clin Proc ...

https://en.wikipedia.org/wiki/Anti-nuclear_antibody

... large cell lymphoma of the B-cell type, although T cell lymphomas have also been described. ... The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other ... Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common ... Large deep orbital dermoid cysts can cause pressure effects on the muscles and optic nerve, leading to diplopia and loss of ...

https://en.m.wikipedia.org/wiki/Eye_neoplasm

... integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large ... "Expression of cadherin-8 in renal cell carcinoma and fetal kidney". International Journal of Cancer. 101 (4): 327-34. doi: ... cell-cell junction assembly. • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules. • cell-cell ... cell-cell adherens junction. • cell surface. • catenin complex. Biological process. • response to cold. • cell adhesion. • ...

https://en.wikipedia.org/wiki/CDH8_

Cell Tropism[edit]. Hepadnaviruses, as their "hepa" name implies, infect liver cells and cause hepatitis. This is true not only ... The L (for "large") envelope protein contains all three subunits. The M (for "medium") protein contains only preS2 and S. The S ... Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ... The virus binds to specific receptors on cells and the core particle enters the cell cytoplasm. This is then translocated to ...

https://en.wikipedia.org/wiki/Hepadnaviridae

Mostly these are squamous cell carcinomas.[17][18]. Food debris, desquamated epithelial cells and bacteria often form a visible ... Tongues of seals and whales have been eaten, sometimes in large quantities, by sealers and whalers, and in various times and ... The tongue is equipped with many taste buds on its dorsal surface, and each taste bud is equipped with taste receptor cells ... Chemicals that stimulate taste receptor cells are known as tastants. Once a tastant is dissolved in saliva, it can make contact ...

https://en.m.wikipedia.org/wiki/Human_tongue

Small cell carcinoma is a very rare (1%[77]) type of prostate cancer that cannot be diagnosed using the PSA.[77][78] As of 2009 ... Two large genome-wide association studies linking single nucleotide polymorphisms (SNPs) to prostate cancer were published in ... lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration". Cell Stem ... "Small-cell carcinoma of the prostate". Journal of the Royal Society of Medicine. 90 (6): 340-1. PMC 1296316 . PMID 9227387.. ...

https://fa.wikipedia.org/wiki/سرطان_پروستات?match=en

Large-cell carcinomas can begin in any part of the lung and tend to grow very quickly. ... of all lung cancers are large-cell carcinomas. There is some dispute as to whether these constitute a distinct type of cancer ... or are merely a group of unusual squamous cell carcinomas and adenocarcinomas. ... Other articles where Large-cell carcinoma is discussed: … ... Large-cell carcinoma. pathology. THIS IS A DIRECTORY PAGE. ...

https://www.britannica.com/science/large-cell-carcinoma

... Cancer Control. 2006 Oct;13(4):270-5. doi: 10.1177/107327480601300404. ... Background: Large-cell neuroendocrine carcinoma (LCNEC) of the lung displays morphologic and immunohistochemical ... characteristics common to neuroendocrine tumors and morphologic features of large-cell carcinomas. Because surgical resection ... considerable debate has emerged as to whether these tumors should be classified and treated as NSCLC or small-cell lung cancer ...

https://pubmed.ncbi.nlm.nih.gov/17075564/?dopt=Abstract

Large Cell Carcinoma A type of lung cancer that usually develops in the airways and is characterised by large rounded cells. ... Cancer is a disease of the cells, which are the bodys basic building blocks. ...

https://www.cancervic.org.au/glossary/definition.aspx?term=Large%20Cell%20Carcinoma

Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to ... Chemotherapy Effective For Patients With Resected SCLC Or Large-Cell Neuroendocrine Carcinoma. by editor ... concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were ... Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. Of those, about 30 percent of patients have ...

http://www.redorbit.com/news/health/1112634399/chemotherapy-effective-for-patients-with-resected-sclc-or-large-cell-neuroendocrine-carcinoma/

Histologically, this type has sheets of highly atypical cells with focal... more ... typically manifesting as a large peripheral mass on chest radiograph. ... Large-cell carcinoma accounts for 10-15% of lung cancers, ... How is large-cell carcinoma subtype of non-small cell lung ... Large-cell carcinoma accounts for 10-15% of lung cancers, typically manifesting as a large peripheral mass on chest radiograph ...

https://www.medscape.com/answers/279960-84964/how-is-large-cell-carcinoma-subtype-of-nonsmall-cell-lung-cancer-nsclc-characterized

... but Memorial Sloan Kettering experts have experience treating both large cell neuroendocrine carcinoma and small cell carcinoma ... Gastrointestinal small cell carcinoma and large cell carcinoma are usually diagnosed at an advanced stage, after they have ... The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. ... Because small cell and large cell neuroendocrine carcinomas of the gastrointestinal tract are usually found at an advanced ...

https://www.mskcc.org/cancer-care/types/gastrointestinal-neuroendocrine/large-cell-small-cell-gastrointestinal-neuroendocrine-carcinoma

Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study ... Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. Definite treatment strategy has not been ... In recent years, large cell neuroendocrine carcinomas (LCNEC) that differ in cell morphology compared with small cell carcinoma ... A Case of the Large Cell Neuroendocrine Carcinoma of the Urinary Bladder,. Case Reports in Medicine,. vol. 2013. ,. Article ID ...

https://www.hindawi.com/journals/crim/2013/804136/

... with the three most common ones being small cell carcinoma, large cell neuroendocrine carcinoma and carcinoid tumors. Based on ... Morphologically, it is the large cell carcinoma in which tumor cells are typically more than three times greater than the ... Large cell neuroendocrine carcinoma primarily in the pericardium. a case report and literature review. Yin, Yue1; Zhang, Yun1; ... Large cell neuroendocrine carcinoma of the endometrium: a case report and literature review. Taiwan J Obstet Gynecol 2018; 57: ...

https://journals.lww.com/cmj/Fulltext/2020/01050/Large_cell_neuroendocrine_carcinoma_primarily_in.19.aspx

Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to ... Chemotherapy effective for patients with resected SCLC or large-cell neuroendocrine carcinoma. 18.06.2012 ... concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were ... Further reports about: , Association , IASLC , SCLC , Small-cell lung cancer , cell lung cancer , chemotherapy , lung cancer , ...

https://www.innovations-report.com/html/reports/medicine-health/chemotherapy-effective-patients-resected-sclc-large-197454.html

... P. N. Shakuntala,1 K. Uma ... C. F. Lindboe, "Large cell neuroendocrine carcinoma of the ovary," APMIS, vol. 115, no. 2, pp. 169-176, 2007. View at Publisher ... P. Dundr, D. Fischerová, C. Povýšil, and D. Cibula, "Primary pure large-cell neuroendocrine carcinoma of the ovary," Pathology ... J. M. Kim, H. C. Shin, and M. J. Kim, "Ovarian large cell neuroendocrine carcinoma associated with endocervical-like mucinous ...

https://www.hindawi.com/journals/crionm/2012/120727/ref/

Large Cell" by people in Harvard Catalyst Profiles by year, and whether "Carcinoma, Large Cell" was a major or minor topic of ... "Carcinoma, Large Cell" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Surgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical ... Carcinoma, Large Cell*Carcinoma, Large Cell. *Carcinomas, Large Cell. *Cell Carcinoma, Large ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Carcinoma,%20Large%20Cell

大腸内分泌細胞癌の2例 [in Japanese] TWO CASES OF ENDOCRINE CELL CARCINOMA OF IN THE LARGE BOWEL [in Japanese] * * 佐藤美信 SATO Harunobu ... A CASE OF ENDOCRINE CELL CARCINOMA OF THE RECTUM [in Japanese] YAMAUCHI Kimi , MIYATA Tomoyuki , OKADA Naomasa , NITTA Toyoo , ... A Case of Endocrine Cell Carcinoma of the Rectum [in Japanese] FUJIWARA Ichiro , KATO Yasuyuki , MAEDA Kiyoshi , KATSURAGI Kei ... A CASE OF ENDOCRINE CELL CARCINOMA OF THE RECTUM [in Japanese] YAMAGUCHI Yumi , ASHIDA Keigo , SHIBATA Shunsuke , ISHIGURO ...

https://ci.nii.ac.jp/naid/10008435957

What is large cell carcinoma? Meaning of large cell carcinoma medical term. What does large cell carcinoma mean? ... Looking for online definition of large cell carcinoma in the Medical Dictionary? large cell carcinoma explanation free. ... large cell carcinoma, and squamous cell carcinoma.. oat cell carcinoma a form of small cell carcinoma in which the cells are ... large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.. cholangiocellular carcinoma a rare type of ...

https://medical-dictionary.thefreedictionary.com/large+cell+carcinoma

Akamatsu S, Kanamaru S, Ishihara M, Sano T, Soeda A, Hashimoto K. Primary large cell neuroendocrine carcinoma of the urinary ... Noske A, Pahl S. Combined adenosquamous and large-cell neuroendocrine carcinoma of the gallbladder. Virch Arch 2006;449:135-136 ... Hao H, Itoyama M, Tsubamoto H, Tsujimoto M, Hirota S. Large cell neuroendocrine carcinoma of the cervix associated with ... Deodhar KK, Kerkar RA, Suryawanshi P, Menon H, Menon S. Large cell neuroendocrine carcinoma of the endometrium: an extremely ...

https://link.springer.com/article/10.1007%2Fs12022-012-9229-4

Lung Large Cell Carcinoma Description SK-LC-05 is a human lung cancer cell line. Source This cell line was established from a ... lung metastasis in a patient with lung large cell carcinoma. ... Cancer Type: Lung Large Cell Carcinoma. Description. SK-LC-05 ... This cell line was established from a lung metastasis in a patient with lung large cell carcinoma. ... Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies. Proc. Natl. Acad. Sci ...

https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-lc-05-human-lung-cancer-large-cell-carcinoma-cell-line

... but patients with large tumors (> 5 cm) have elevated rates of locoregional recurrence. With conformal radiation... ... Dose escalation Anal cancer Large tumors Overall survival benefit Squamous cell carcinoma ... The effect of dose escalation for large squamous cell carcinomas of the anal canal. ... Squamous cell carcinoma of the anus at one hospital from 1948 to 1984. Br J Surg. 1989;76:806-10.CrossRefGoogle Scholar ...

https://link.springer.com/article/10.1007/s12094-018-1863-y

... large cell carcinoma of the lung Clear cell carcinoma of the lung Lymphoepithelioma-like carcinoma of the lung Large-cell lung ... carcinoma with rhabdoid phenotype Large cell neuroendocrine carcinoma of the lung One clinically significant subtype is "large- ... LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher ... Large-cell carcinoma (LCC, LCLC) is a heterogeneous group of undifferentiated malignant neoplasms that lack the cytologic and ...

https://en.wikipedia.org/wiki/Large-cell_lung_carcinoma

Learn the symptoms, treatments, and prognosis of large cell carcinoma of the lungs. ... Large cell carcinoma is a form of non-small cell lung cancer. ... Large cell carcinomas are also called large cell lung cancers. ... One variant of large cell carcinoma, large cell neuroendocrine carcinoma, has a poorer prognosis than large cell carcinoma. ... Large cell carcinoma of the lungs is a form of non-small cell lung cancer. Non-small cell lung cancers account for 80 percent ...

https://www.verywellhealth.com/large-cell-carcinoma-of-the-lungs-2249356

SC-002 in Small Cell Lung Cancer and Large Cell Neuroendocrine Carcinoma. The safety and scientific validity of this study is ... Part 1A is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with ... Small Cell Lung Carcinoma. Carcinoma, Neuroendocrine. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic ... This is a Phase 1a/1b study of SC-002 in patients with relapsed small cell lung cancer (SCLC) or large cell neuroendocrine ...

https://www.clinicaltrials.gov/ct2/show/NCT02500914

... sequencing of pulmonary large cell neuroendocrine carcinoma reveals small cell carcinoma-like and non-small cell carcinoma-like ... Large cell neuroendocrine carcinoma: an aggressive form of non-small cell lung cancer. J Thorac Cardiovasc Surg 2005;130:166-72 ... Purpose: Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell ... Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung. Tomohiro Miyoshi, Shigeki Umemura, Yuki Matsumura, ...

http://clincancerres.aacrjournals.org/content/23/3/757

HomeIndustry SolutionsOncologyPreclinicalCell LinesNCI-H1299-Luc: Human Large Cell Lung Carcinoma ... Please note that cell lines are not for sale and unavailable for purchase from Covance.*** ... Cell LinesTumor ModelsCAR TIn VitroTumor SpotlightsPosters Choose Subcategory. Cell Lines. Tumor Models. CAR T. In Vitro. Tumor ... Biomarker Solutions Biomarker Solution Center Companion Diagnostics Genomics Solutions Cell and Gene Therapies Immuno-Oncology ...

https://www.covance.com/industry-solutions/oncology/preclinical/complete-cell-line-list/nci-h1299-luc.html

The RNA-seq profile of LCLC and other non-small cell lung carcinoma (NSCLC) was downloaded from Gene Expression Omnibus (GEO) ... This study also finds tools to diagnose LCLC and differentiate LCLC with other Non-Small Cell Lung Cancer. ... We also identified the LncRNA differentially expressed in LCLC compared to lung squamous carcinoma (LUSC) and Lung- ... Undifferentiated large cell lung carcinoma (LCLC) accounts for 2.9-9% of total lung cancers. Recently, RNA-seq based studies ...

https://www.mdpi.com/2311-553X/4/1/4/htm

Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma (NICCI). The safety and ... Patients with at least 1 large (≥ 2 cm in diameter in head/neck region, ≥ 5 cm for trunk/extremities) basal cell carcinoma (BCC ... Patients with large (as defined above) recurrent basal cell carcinoma are also eligible. ... Carcinoma, Basal Cell. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Basal Cell. ...

https://clinicaltrials.gov/show/NCT03035188

A 73 year-old man presented with a large ulcerated plaque almost completely covered with a thick hemorrhagic black crust on the ... Large basal cell carcinoma of the scalp. Zeitschrift:. Wiener Medizinische Wochenschrift > Ausgabe 5-6/2017 Autoren:. MD José ... Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical approach. ... Erratum to: Rare association of cystic squamous cell carcinoma and small lymphocytic B cell lymphoma: successful surgical ...

https://www.springermedizin.at/large-basal-cell-carcinoma-of-the-scalp/14929104

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from transformed epithelial ... It is currently considered to be a subtype of large cell lung carcinoma. LCNEC is often generically grouped among the non-small ... "combined large cell neuroendocrine carcinoma" (c-LCNEC). Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; ... cell lung carcinomas. The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely " ...

https://en.wikipedia.org/wiki/Large_cell_neuroendocrine_carcinoma_of_the_lung

Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome. Jules L. Derks, ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ... Molecular Subtypes of Pulmonary Large-cell Neuroendocrine Carcinoma Predict Chemotherapy Treatment Outcome ...

http://clincancerres.aacrjournals.org/content/24/1/33

Large Cell Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma, Adenosquamous Cell CarcinomaTrial Of CP-751, 871 ... Large Cell Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma, Adenosquamous Cell Carcinoma ... Non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. At least 1 ... Non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. At least 1 ...

https://www.pfizer.com/science/find-a-trial/nct00673049

... small cell neuroendocrine carcinoma, squamous cell carcinoma, adenocarcinoma and large cell carcinomas ... There are four major types of lung carcinomas, ... Large cell carcinoma of the lung - a vanishing entity? Autor:. ... Large cell carcinoma of the lung - a vanishing entity?. Zeitschrift:. memo - Magazine of European Medical Oncology > Ausgabe 1/ ... or cisplatin and erythropoietin in pretreated patients with in field relapse after radiation therapy of non-small cell lung ...

https://www.springermedizin.at/large-cell-carcinoma-of-the-lung-a-vanishing-entity/14930008

We report a case of large cell neuroendocrine carcinoma of the uterine cervix. A 33-year-old woman presented with a 4-month ... A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. She was ... Immunohistochemistry of the tumour cells showed strong positivity for the neuroendocrine markers synaptophysin and a very high ...

https://casereports.bmj.com/content/12/1/bcr-2018-225880

Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. Am J Surg Pathol. 1998 ... Large cell neuroendocrine carcinoma of the lung: a retrospective analysis of 144 surgical cases. Lung Cancer. 2006;53:111-115 ... Large cell neuroendocrine carcinoma of the lung: a 10-year clinicopathologic retrospective study. Ann Thorac Surg. 2004;77:1163 ... Large cell neuroendocrine carcinoma of prostate: a clinicopathologic summary of 7 cases of a rare manifestation of advanced ...

http://www.jcancer.org/v03p0096.htm

Large-cell neuroendocrine carcinoma (LCNEC) of the lung displays morphologic and immunohistochemical characteristics common to neuroendocrine tumors and morphologic features of large-cell carcinomas. (nih.gov)
Because surgical resection of LCNEC in many series has been described with 5-year actuarial survival that is far worse than that reported for other histologic variants of non-small-cell lung cancer (NSCLC), considerable debate has emerged as to whether these tumors should be classified and treated as NSCLC or small-cell lung cancer. (nih.gov)
Whereas large-cell neuroendocrine carcinoma (LCNEC) is a subgroup of large-cell carcinoma, that has characteristics similar to SCLC. (redorbit.com)
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is very rare. (hindawi.com)
Histological examination revealed a rosette arrangement of the tumor cells by HE staining and immunohistochemical study revealed positive CD 56, synaptophysin, and chromogranin A (LCNEC). (hindawi.com)
In recent years, large cell neuroendocrine carcinomas (LCNEC) that differ in cell morphology compared with small cell carcinoma have been occasionally reported [ 1 ]. (hindawi.com)
Tissue analysis revealed adenocarcinoma, so he was diagnosed with primary bladder cancer (LCNEC and urothelial carcinoma) and primary lung cancer (adenocarcinoma). (hindawi.com)
LCNEC is one group of neuroendocrine carcinomas in the lungs and bronchial tubes that was first reported by Travis et al. (hindawi.com)
Histological characteristics of LCNEC include the following: (1) growth patterns such as organoid, trabecular, and rosette, (2) large polymorphic tumor cells, low N/C ratio, and crude chromatin with obvious nucleolus, (3) high rate of mitosis, (4) necrosis, and (5) neuroendocrine tumor characteristics present in immunohistology and electron microscopy. (hindawi.com)
In addition, a "subvariant", called "combined large-cell neuroendocrine carcinoma" (or c-LCNEC), is recognized under the new system. (wikipedia.org)
To be designated a c-LCNEC, the tumor must contain at least 10% LCNEC cells, in combination with at least 10% of other forms of NSCLC. (wikipedia.org)
This is a Phase 1a/1b study of SC-002 in patients with relapsed small cell lung cancer (SCLC) or large cell neuroendocrine carcinoma (LCNEC). (clinicaltrials.gov)
Part 1A is a dose escalation study in patients with small cell lung cancer or large cell neuroendocrine carcinoma with cytologically confirmed, limited or extensive SCLC or LCNEC that have relapsed or refractory limited or extensive disease following no more than 2 prior chemotherapy regimens. (clinicaltrials.gov)
Although large-cell neuroendocrine carcinoma (LCNEC) of the lung shares many clinical characteristics with small-cell lung cancer (SCLC), little is known about its molecular features. (aacrjournals.org)
We performed targeted capture sequencing of all the coding exons of 244 cancer-related genes on 78 LCNEC samples [65 surgically resected cases, including 10 LCNECs combined with non-small cell lung cancer (NSCLC) types analyzed separately, and biopsies of 13 advanced cases]. (aacrjournals.org)
Large-cell neuroendocrine carcinoma (LCNEC) of the lung, which has been histologically categorized as high-grade neuroendocrine carcinoma with small-cell lung cancer (SCLC), is a highly malignant tumor with a poor prognosis. (aacrjournals.org)
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. (wikipedia.org)
LCNEC is often generically grouped among the non-small cell lung carcinomas. (wikipedia.org)
The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely "combined large cell neuroendocrine carcinoma" (c-LCNEC). (wikipedia.org)
Previous genomic studies have identified two mutually exclusive molecular subtypes of large-cell neuroendocrine carcinoma (LCNEC): the RB1 mutated (mostly comutated with TP53 ) and the RB1 wild-type groups. (aacrjournals.org)
This case report describes a 77-year-old man with a large cell neuroendocrine carcinoma (LCNEC) of the lung and metastases from this primary cancer in the prostate. (jcancer.org)
We herein report a case of prostatic metastasis of pulmonary large cell neuroendocrine carcinoma (LCNEC). (jcancer.org)
Large cell neuroendocrine lung carcinoma (LCNEC) is a rare, highly malignant neoplasm. (termedia.pl)
1] on the efficacy of different chemotherapeutic regimens in a large series of 128 patients with stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung. (ersjournals.com)
Malignancy of pulmonary large cell carcinomas (LCC) increases from classic LCC through LCC with neuroendocrine morphology (LCCNM) to large cell neuroendocrine carcinomas (LCNEC). (scielo.br)
1) recently proposed to subdivide LCC into three subtypes: classic LCC, LCC with neuroendocrine morphology (LCCNM) and large cell neuroendocrine carcinoma (LCNEC), although the LCCNM subtype has not yet been recognized officially in the current WHO classification (2004). (scielo.br)
In 2015, large cell neuroendocrine carcinoma (LCNEC) was removed from the large cell carcinoma group and classified with small cell lung carcinoma (SCLC) constituting two members of the high-grade neuroendocrine tumors (NETs) of the lung. (jcancer.org)
To the best of our knowledge, this study involved the largest number of high-grade LCNEC patients to date, with respect to a comparison between high-grade LCNEC and high-grade SCLC patients. (jcancer.org)
In our centre, we diagnose a case of Large-Cell Neuroendocrine Carcinoma (LCNEC) of the, endometrium in an 82 y old female. (alliedacademies.org)
Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. (biomedcentral.com)
LCNEC of the gallbladder is thought to be extremely rare and is usually found in combination with other histological carcinoma types, such as adenocarcinoma, as determined histologically. (biomedcentral.com)
Is the sum of positive neuroendocrine immunohistochemical stains useful for diagnosis of large cell neuroendocrine carcinoma (LCNEC) on biopsy specimens? (maastrichtuniversity.nl)
BACKGROUNDS Large cell neuroendocrine carcinoma (LCNEC) is well-known as a lung cancer subtype. (semanticscholar.org)
Objective: Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. (elsevier.com)
Introduction: To treat LCNEC with non-small cell lung carcinoma type chemotherapy (NSCLC-ct, i.e. gemcitabine/taxanes or pemetrexed) or small cell lung carcinoma type (SCLC-ct, i.e. platinumetoposide) is subject of debate. (nrs-science.nl)
However, acquired resistance due to histological transformation into a large cell neuroendocrine carcinoma (LCNEC) is uncommon. (kjim.org)

Sato K, Imai T, Shirota Y, Ueda Y, Katsuda S. Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. (springer.com)

Research presented in the July 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concluded that patients with limited large cell neuroendocrine tumors or with limited stage small-cell lung cancer who were treated with perioperative chemotherapy and surgery had better overall survival outcomes than patients treated with surgery alone. (redorbit.com)

A few neuroendocrine tumors found in the gastrointestinal tract are made of fast-growing, poorly differentiated cancer cells, and respond to different treatments than those used for carcinoid tumors. (mskcc.org)
Whether dose escalation of large tumors may improve local control and colostomy-free survival remains an important question and is the subject of ongoing trials. (springer.com)
They are named for the appearance of large round cells when examined under the microscope, although the tumors themselves tend to be large as well when diagnosed. (verywellhealth.com)
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, and its incidence has been increasing in the last few decades, with a large prevalence of small tumors ( 1 ). (scielo.br)
Conversely, primary thyroid lymphoma (PTL) is a rare disease that accounts for 5% of all thyroid tumors: in 70% of cases it appears as diffuse large B-cell lymphoma (DLBCL), which usually presents with a more aggressive course and has a worse outcome. (scielo.br)
Wang J, Ye L, Cai H, Jin M. Comparative study of large cell neuroendocrine carcinoma and small cell lung carcinoma in high-grade neuroendocrine tumors of the lung: a large population-based study. (jcancer.org)
Large cell neuroendocrine carcinoma is defined as a variant form of large cell carcinoma, and is classified in the wide spectrum of primary neuroendocrine tumors together with small cell carcinoma (SCC) and atypical carcinoid tumor. (biomedcentral.com)
In these cases, the tumors are classified as combined small cell lung carcinoma (c-SCLC), [7] and are (usually) treated like "pure" SCLC. (wikipedia.org)
The tumors associated with this type of cancer are also typically large. (facty.com)
Considerable debate has emerged as to whether these tumors should be classified and treated as non-small cell lung cancers or small cell lung cancers. (elsevier.com)
Methods: An analysis of our tumor registry was performed to identify all patients undergoing surgical resection of lung cancer between July 1, 1988, and December 31, 2002, for large cell tumors. (elsevier.com)
These tumors tend to grow rapidly and spread more quickly than other types of non-small cell lung cancers. (picmonic.com)
One of the characteristic features of anaplastic lymphoma kinase (ALK) + , anaplastic large cell lymphoma (ALK + ALCL) is the constitutive activation of signal transducers and activators of transcription-3 (STAT3), a defect believed to be important for the pathogenesis of these tumors. (nature.com)
The IL-22 receptor, a heterodimer composed of IL-22R1 and IL-10R2, was expressed in all ALK + ALCL cell lines and tumors examined. (nature.com)
A recent published study using large-scale microarray gene expression profiling also described the expression of IL-22 among ALK − and ALK + ALCL tumors and cell lines. (nature.com)
These tumors usually present as a large peripheral mass with prominent necrosis . (icnet.uk)
These tumors are referred to as anaplastic or undifferentiated carcinomas. (wikipedia.org)
Very rarely, tumors may contain individuals components resembling both carcinoma and true sarcoma , including carcinosarcoma and pulmonary blastoma . (wikipedia.org)
Neuroendocrine tumors are tumors that develop from the cells of the diffuse neuroendocrine system, such as the enterochromaffin (EC) cells. (encyclopedia.com)
These tumors are characterized by the presence of cells that possess secretory granules and have the ability to secrete neurohormones. (encyclopedia.com)
Neuroendocrine tumors therefore represent a large class of cancers that can occur wherever neuroendocrine cells are found throughout the body. (encyclopedia.com)
They are sometimes called carcinoid tumors, but it would be more accurate to consider these tumors as a sub-category of the larger family of neuroendocrine tumors. (encyclopedia.com)
Neuroendocrine tumors are also known as apudomas, or tumors that contain apud cells. (encyclopedia.com)
Because they can occur wherever neuroendocrine cells are found, neuroendocrine tumors come in a wide variety of types and have been classified according to their site of origin, usually either as digestive system , pancreatic or lung neuroendocrine tumors. (encyclopedia.com)
Midgut tumors are the most common variety and they include small and large intestine tumors. (encyclopedia.com)
Functionally active neuroendocrine tumors display specific symptoms, such as the excessive release of specific neurohormones from the tumor cell, as described above for pancreatic neuroendocrine tumors. (encyclopedia.com)
Grade 1 neuroendocrine carcinomas are also known as carcinoid tumors. (encyclopedia.com)
Grade 2 include tumors such as atypical carcinoid tumors, medullary thyroid carcinomas, and some pancreatic endocrine tumors. (encyclopedia.com)

Small-cell lung cancer (SCLC) represents about 15 percent of lung cancers annually. (redorbit.com)
citation needed] LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. (wikipedia.org)
Lung cancer is the major cause of cancer-related deaths worldwide [ 1 ] and is generally divided into small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) [ 2 ]. (mdpi.com)
Next-generation sequencing (NGS) for TP53, RB1, STK11, and KEAP1 genes, as well as IHC for RB1 and P16 was performed on 79 and 109 cases, respectively, and correlated with overall survival (OS) and progression-free survival (PFS), stratifying for non-small cell lung cancer type chemotherapy including platinum + gemcitabine or taxanes (NSCLC-GEM/TAX) and platinum-etoposide (SCLC-PE). (aacrjournals.org)
To compare the presenting and prognostic characteristics of patients with large cell neuroendocrine lung cancer (LCNELC) with those of patients with small cell lung cancer (SCLC) or other large cell carcinomas (OLCs) and to compare overall survival (OS) and lung cancer-specific survival (LCSS) rates for patients undergoing definitive resection without radiotherapy (S-NoRT). (nih.gov)
In our study, patients with metastatic disease treated either in an adjuvant setting or post-surgery with platinum/etoposide, a conventional regimen for small cell lung cancer (SCLC), showed a significant clinical benefit in terms of overall survival compared to patients treated with chemotherapeutic regimens used for non-small cell lung cancer (NSCLC). (ersjournals.com)
Non-small-cell lung carcinoma ( NSCLC ) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). (wikipedia.org)
NSCLC and small cell lung cancer (SCLC) differ in how the cells look under a microscope, their origin, how quickly they spread to other parts of the body, and how they are treated. (cancersupportcommunity.org)
Often has features of both small cell lung carcinoma (SCLC) and non-small cell lung cancer (NSCLC). (ronnyallan.net)
Methods: For this population based retrospective cohort study all diagnoses of stage IV ct treated high grade neuroendocrine carcinomas (NEC, not being SCLC) were retrieved from the Netherlands Cancer Registry and Pathology Registry (PALGA) (2003-2012). (nrs-science.nl)
Small cell lung cancer (SCLC) accounts for about 15% of all lung cancer cases. (medicalnewstoday.com)
Possible mechanisms of acquired or secondary resistance to erlotinib include second mutations in the EGFR gene such as T790M, activation of an alternative pathway including Met or HER2 amplification, histological transformation to small cell lung cancer (SCLC) and epithelial to mesenchymal transition [ 1 ]. (kjim.org)
A rare form of cancer, similar to SCLC in prognosis and treatment, except that the cancer cells are unusually large. (encyclopedia.com)

A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid HT. (scielo.br)
Diffuse large B cell lymphoma (DLBCL) is one of the most common acquired immune deficiency syndrome (AIDS)-defining malignancies among human immunodeficiency virus-infected patients, and rectal cancer has recently emerged as a prevalent non-AIDS-defining malignancy. (bvsalud.org)
The two biopsies revealed squamous cell carcinoma and diffuse large B-cell lymphoma (DLBCL), respectively. (ekjm.org)

cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles , consisting of two layers of cells surrounding a minute lumen. (thefreedictionary.com)
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. (thefreedictionary.com)
SHANGHAI, Oct. 22, 2019 /PRNewswire/ -- The world-class journal Cell , an international high-impact journal, published the article "Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma in China. (pharmiweb.com)
To date, this is the largest cohort study on hepatocellular carcinoma (HCC) in China, especially on the multi-omics proteogenomic analysis of HBV-related HCC. (pharmiweb.com)
WebMD explains the causes, symptoms, and treatment of hepatocellular carcinoma, a cancer that begins in your liver. (webmd.com)

of all lung cancers are large-cell carcinoma s. (britannica.com)
Large-cell carcinoma accounts for 10-15% of lung cancers, typically manifesting as a large peripheral mass on chest radiograph. (medscape.com)
[ 11 ] Large-cell undifferentiated cancers carry the same prognosis as do adenocarcinomas and are combined with them in clinical trials. (medscape.com)
Non-small cell lung cancers account for 80 percent of lung cancers, and of these, roughly 10 percent are large cell carcinoma of the lung. (verywellhealth.com)
Large cell carcinomas are also called large cell lung cancers. (verywellhealth.com)
Smoking is the greatest risk factor and plays a larger role in large cell lung cancers than other forms of non-small cell lung cancer such as lung adenocarcinoma. (verywellhealth.com)
Undifferentiated large cell lung carcinoma (LCLC) accounts for 2.9-9% of total lung cancers. (mdpi.com)
Large cell lung carcinoma is the fourth most common lung cancer and accounts for nearly 2.9-9% of all lung cancers [ 4 ]. (mdpi.com)
Pie chart showing incidences of non-small cell lung cancers as compared to small cell carcinoma shown at right, with fractions of smokers versus non-smokers shown for each type. (wikipedia.org)
The non-small cell type accounts for around three quarters of cancers of the lung. (viewthegoals.com)
Results: Of the 2099 patients who underwent resection, 82 (3.9%) had large cell lung cancers. (elsevier.com)
Non-small cell lung cancers that present early in the disease process are generally treated upfront with surgical resection. (picmonic.com)
Lung cancers are widely divided into- small cell lung cancers and non-small cell lung cancers. (medeguru.com)
Large cell carcinomas develop and spread very quick than other types of non-small cell cancers. (medeguru.com)
In the United States, 80 to 85 percent of lung cancers are non-small cell lung cancers (NSCLC). (cancersupportcommunity.org)
Squamous cell lung carcinoma represents between 20 % and 30 % of all lung cancers in the U.S . Before the early to mid- 1980s , squamous cell carcinoma of the lung was the most common histological type. (icnet.uk)
spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
Large cell carcinoma Accounts for 5-10% of all lung cancers. (slideplayer.com)
There was no statistically significant difference between the overall survival of patients with large cell neuroendocrine carcinoma and those with other non-small cell lung cancers. (elsevier.com)
Conclusion: In terms of prognosis, large cell neuroendocrine carcinoma is distinctly different from other non-small cell lung cancers. (elsevier.com)
the prognosis of the stage I disease of large cell neuroendocrine carcinoma was poorer than that of the same stage of other non-small cell lung cancers. (elsevier.com)
Because of its aggressive clinical behavior and poor prognosis, large cell neuroendocrine carcinoma should be recognized as one of the poorest prognostic subgroups among primary lung cancers, and therefore novel therapeutic approaches should be established. (elsevier.com)

[10] [11] However, recent studies suggest that the "ratio of centrally-to-peripherally occurring" lesions may be converging toward unity for both adenocarcinoma and squamous cell carcinoma. (wikipedia.org)
Large cell carcinoma does not exhibit glandular or squamous differentiation (which is seen in adenocarcinoma and squamous cell carcinoma respectively). (picmonic.com)
Refers to a mixed tumor containing both adenocarcinoma and squamous cell carcinoma, wherein each of these cell types comprise at least 10% of the tumor volume. (wikipedia.org)

basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells , rarely metastatic but locally invasive and aggressive. (thefreedictionary.com)
Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction. (springer.com)
Large-cell carcinoma (LCC, LCLC) is a heterogeneous group of undifferentiated malignant neoplasms that lack the cytologic and architectural features of small cell carcinoma and glandular or squamous differentiation. (wikipedia.org)
Large cell carcinomas of the lung showing evidence of neuroendocrine differentiation is a distinctive clinicopathologic disease and should not be classified with unspecified large cell anaplastic carcinomas of the lung. (histopathology-india.net)
Cases were then segregated into large cell neuroendocrine carcinomas, mixed large cell neuroendocrine carcinomas (in which at least one portion of the tumor was a large cell neuroendocrine carcinoma), or large cell carcinomas on the basis of morphology and differentiation. (elsevier.com)
Accurate differentiation of large cell neuroendocrine carcinoma from large cell carcinoma is important because it identifies those patients at highest risk for the development of recurrent lung cancer. (elsevier.com)
A cancer of the lung with neuroendocrine differentiation in which the cells are large and look abnormal when viewed under a microscope. (ronnyallan.net)
Large cell carcinoma of the lung has histology that lacks glandular or squamous differentiation by light microscopy and has no cytological features of small cell carcinoma. (icnet.uk)
the histology shows spindle-shaped malignant cells without morphological differentiation. (icnet.uk)
Refers to a carcinoma with observable features and characteristics indicative of squamous differentiation (intercellular bridges, keratinization, squamous pearls). (wikipedia.org)
Histologic examination of the resected specimen disclosed obvious differentiation toward hepatocytes in tumor cells and scanty atypia in nuclei. (fujita-hu.ac.jp)

a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. (thefreedictionary.com)
adenocystic carcinoma ( adenoid cystic carcinoma ) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. (thefreedictionary.com)
bronchioalveolar carcinoma ( bronchiolar carcinoma ) ( bronchioloalveolar carcinoma ) ( bronchoalveolar carcinoma ) a variant type of adenocarcinoma of the lung , with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. (thefreedictionary.com)
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
LCC is categorized as a type of NSCLC (non-small-cell lung carcinoma) which originates from epithelial cells of the lung. (wikipedia.org)
Epithelial membrane antigen was focally and weakly positive and p53 was positive in 60% of tumoral cells. (histopathology-india.net)
Large cell lung carcinoma (LCLC) is a heterogeneous group of undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung. (wikipedia.org)
characterized histologically by prominent peripheral palisading of cell nuclei (rather like the basal epithelial layer of the bronchi). (icnet.uk)
CUP), but that possess certain specific molecular, cellular, and histological characteristics typical of epithelial cells. (wikipedia.org)

Real world prospective experience of axitinib in metastatic renal cell carcinoma in a large comprehensive cancer centre. (urotoday.com)
Axitinib has shown activity in metastatic renal cell carcinoma (mRCC) in a large phase III clinical trial and was approved in patients who failed first-line therapy. (urotoday.com)
International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk group classification was good, intermediate and poor in 13%, 54% and 32%, respectively. (urotoday.com)
Randomized phase II multicenter trial of two schedules of lapatinib as first- or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer. (semanticscholar.org)
Fine-needle aspiration cytology of the cervical mass suggested poorly differentiated metastatic carcinoma. (biomedcentral.com)
Recently, we have encountered large cell neuroendocrine carcinoma of the submandibular gland that was diagnosed at autopsy, but was difficult to distinguish from metastatic tumor. (biomedcentral.com)
Metastatic carcinoma was suspected, but primary organs could not be detected. (biomedcentral.com)
People with carcinoma of unknown primary (CUP) have metastatic cancer (cancer that started somewhere else in the body and spread to another area), but the place from where the cancer started is unknown. (webmd.com)

It also lacks cytologic features of small cell carcinoma. (picmonic.com)

Large cell carcinoma is the fourth most common histological type of lung cancer in the United States. (columbia.edu)
Based on histological and immunohistochemical findings, the patient was diagnosed as having pulmonary large cell carcinoma with rhabdoid phenotype. (histopathology-india.net)
Histological examination of the submandibular tumor revealed a solid growth formed of large polygonal atypical cells. (biomedcentral.com)
Refers to a heterogeneous group of high-grade carcinomas that feature cells lacking distinct histological or cytological evidence of any of the more specifically differentiated neoplasms . (wikipedia.org)

To explore the influencing factors of perioperative renal function change and their relationship with prognosis on renal cell carcinoma (RCC) patients with tumor thrombus after nephrectomy and thrombectomy. (physiciansweekly.com)
Large cell neuroendocrine carcinoma has poor prognosis like SCC. (biomedcentral.com)
Large cell carcinoma of the lung has a strong correlation with smoking and typically has a poor prognosis. (picmonic.com)
There is often a poor prognosis for patients diagnosed with large cell carcinoma of the lung. (picmonic.com)
Most patients with exophytic endobronchial squamous cell carcinoma have a low-grade , early-stage tumor at diagnosis that has a good prognosis . (icnet.uk)

Because small cell and large cell neuroendocrine carcinomas of the gastrointestinal tract are usually found at an advanced stage, treatment often begins with a combination of platinum-based chemotherapy drugs. (mskcc.org)
Survival in Patients with High-Grade Colorectal Neuroendocrine Carcinomas: The Role of Surgery and Chemotherapy. (harvard.edu)
Induction chemotherapy and dose intensification of the radiation boost in locally advanced anal canal carcinoma: final analysis of the randomized UNICANCER ACCORD 03 Trial. (springer.com)
Depending upon the stage, treatments for large cell carcinomas of the lung may include surgery, chemotherapy, radiation therapy, targeted therapy, immunotherapy, or a combination of these. (verywellhealth.com)
[1] [2] As a class, NSCLCs are relatively insensitive to chemotherapy , compared to small cell carcinoma. (wikipedia.org)
Small cell lung cancer (about 20% of the disease) spreads rapidly through the bloodstream and lymphatics, but is better for chemotherapy. (viewthegoals.com)
Chemotherapy usually helps to ensure that cancer cells don't return. (facty.com)
Large cell carcinoma is less responsive to chemotherapy. (picmonic.com)
Downregulation of CD117 by neoadjuvant chemotherapy was seen in large-cell neuroendocrine carcinomas but not small-cell carcinomas. (elsevier.com)
Case 2: A 51-year-old man, receiving whole brain irradiation and salvage chemotherapy for brain relapse of large cell carcinoma of the lung after surgical resection, suddenly complained of severe abdominal pain. (elsevier.com)
Chemotherapy uses drugs to kill cancer cells and stop new cells from growing. (medlineplus.gov)

Histologically, this type has sheets of highly atypical cells with focal necrosis, with no evidence of keratinization (as is typical of SCC) or gland formation (as is typical of adenocarcinomas). (medscape.com)
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements. (thefreedictionary.com)
These lesions were characterised histologically by the presence of typical rhabdoid cells, which are large cells with abundant cytoplasm and eccentric nuclei with central macronucleoli. (ersjournals.com)
Histologically, large cell carcinoma is characterized by large polygonal cells and anaplastic cells growing in solid nests. (picmonic.com)

The following tests may be performed to confirm a diagnosis of large cell neuroendocrine carcinoma or small cell carcinoma. (mskcc.org)
Pathological diagnosis revealed cancer cells with a poor endoplasmic reticulum and elliptical nuclei rich in chromatin with medullary solid growth patterns. (hindawi.com)
Deodhar KK, Kerkar RA, Suryawanshi P, Menon H, Menon S. Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts. (springer.com)
citation needed] LCC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer. (wikipedia.org)
A diagnosis of high-grade large cell neuroendocrine carcinoma of the uterine cervix was made with FIGO stage IIA2. (bmj.com)
This diagnosis is allowed on surgical specimens only, whereas its counterpart in biopsy/cytology samples is non-small- cell lung carcinoma , not otherwise specified. (histopathology-india.net)
We discuss the pathological aspect and diagnostic tool of immunohistochemically stain in 83 y old woman who present with postmenopausal bleeding, in which her histopathology diagnosis was issued as mixed type tumour papillary serous and large neuroendocrine, with FIGO nuclear grade III. (alliedacademies.org)
Microscopic examination revealed multiple fragments of endometrial tissue and, report was issued with a diagnosis of combined endometrial carcinoma with a component of papillary serous endometroid and large neuroendocrine carcinoma. (alliedacademies.org)
The histopathological diagnosis was large cell neuroendocrine carcinoma of the submandibular gland. (biomedcentral.com)
LCLC's have typically comprised around 10% of all NSCLC in the past, although newer diagnostic techniques seem to be reducing the incidence of diagnosis of "classic" LCLC in favor of more poorly differentiated squamous cell carcinomas and adenocarcinomas. (wikipedia.org)
Unfortunately, previous large-scale studies on the possibility of early diagnosis have not shown sufficiently satisfactory results to be meaningful to broad sections of the population. (viewthegoals.com)
Large cell carcinoma is responsible for about ten percent of the non-small cell lung cancer diagnosis. (facty.com)
Large cell carcinoma is often a diagnosis of exclusion and histology shows anaplastic cells and pleomorphic giant cells. (picmonic.com)
Large cell neuroendocrine carcinoma of the maxillary sinus on fine needle aspiration cytology: Report of a rare case with a focus on pitfalls in diagnosis. (semanticscholar.org)
Large cell carcinoma is a diagnosis of exclusion and includes all poorly differentiated Non-Small Cell Carcinomas (NSLC) that cannot be classified further by routine light microscopy. (icnet.uk)
Because large cell carcinoma of the lung represents a diagnosis of exclusion , it is inappropriate to apply the term to small endoscopic biopsies or cytology specimens. (icnet.uk)
The pathologic diagnosis was metastasis of large cell carcinoma to the jejunum. (elsevier.com)
Methods: The histologic characteristics of the patients receiving an initial diagnosis of poorly differentiated non-small cell lung carcinoma (n = 484), small cell carcinoma (n = 55), carcinoid (n = 31), and large cell neuroendocrine carcinoma (n = 12) were retrospectively reviewed according to World Health Organization criteria. (elsevier.com)
Results: A total of 87 patients were given a diagnosis of large cell neuroendocrine carcinoma after the histologic review. (elsevier.com)
Although differention between liver cell adenoma and well-differentiate dhepatocellular carcinoma(Edmondson grade I) is deemed difficult, it is our opinion that the diagnosis of liver cell adenoma can be made by following characteristics: 1) incidence in young adult 2) no underlying liver disease 3) large tumor in the majority of cases 4) histologic findings of monotonous growth and scanty atypia. (fujita-hu.ac.jp)

A tumor of undifferentiated (anaplastic) cells of large size. (harvard.edu)
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation. (thefreedictionary.com)
Large cell carcinoma tends to be a highly anaplastic undifferentiated tumor. (picmonic.com)
Anaplastic cells are poorly differentiated cells that lose their normal morphological characteristics. (picmonic.com)
Anaplastic lymphoma kinase (ALK) + anaplastic large cell lymphoma (ALK + ALCL) is defined as a subtype of T/null-cell non-Hodgkin's lymphoma characterized by the consistent expression of CD30. (nature.com)
There are a large number of rare subtypes of anaplastic, undifferentiated carcinoma. (wikipedia.org)

NCI: A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells. (linkedlifedata.com)
The tumour is composed of sheets of poorly differentiated large tumour cells. (histopathology-india.net)
Subsequently, fine-needle aspiration cytology (FNAC) of the right cervical mass was performed, and it suggested poorly differentiated carcinoma. (biomedcentral.com)
Biopsy of cervix revealed poorly Differentiated Neuroendocrine Carcinoma . (doctorsmedicalopinion.com)
The behavior of large cell carcinoma is that of a poorly differentiated cancer . (icnet.uk)
The outcomes and other clinical characteristics of those patients with large cell neuroendocrine carcinoma were retrospectively analyzed and compared with those of patients with poorly differentiated carcinoma of other histologic types. (elsevier.com)

Surgical treatment of a digital metastasis of a large cell lung neuroendocrine carcinoma: A rare secondary anatomical localization. (harvard.edu)
This cell line was established from a lung metastasis in a patient with lung large cell carcinoma. (mskcc.org)
Shimizu K, Goto T, Maeshima A, Oyamada Y, Kato R. Prostatic Metastasis of Pulmonary Large Cell Neuroendocrine Carcinoma. (jcancer.org)
At first, because of his cervical swelling, hepatic carcinoma with neck metastasis was suspected. (biomedcentral.com)
Multiple linear regression analysis demonstrated a marginal association between cytoplasmic CD117 immunoreactivity and regional lymph node metastasis in small-cell carcinomas but not large-cell neuroendocrine carcinomas. (elsevier.com)

Clinical features of ovarian large-cell neuroendocrine carcinoma: four case reports and review of the literature," Experimental and Therapeutic Medicine , vol. 2, no. 6, pp. 1083-1090, 2011. (hindawi.com)

Cervical Large Cell Neuroendocrine Carcinoma is related to large cell neuroendocrine carcinoma and cystadenoma . (malacards.org)
An important gene associated with Cervical Large Cell Neuroendocrine Carcinoma is CHGA (Chromogranin A). Affiliated tissues include cervix . (malacards.org)

How is large-cell carcinoma subtype of non-small cell lung cancer (NSCLC) characterized? (medscape.com)
It is currently considered to be a subtype of large cell lung carcinoma. (wikipedia.org)
It's a subtype of non-small cell lung cancer, the most common type of lung cancer. (facty.com)
Overall survival by histologic subtype at 5 years was 30.2% for patients with large cell neuroendocrine carcinomas (n = 45), 30.3% for patients with mixed large cell neuroendocrine carcinomas (n = 11), and 71.3% for patients with large cell carcinomas (n = 21). (elsevier.com)

To the best of our knowledge, this is the first report of a co-existing squamous cell carcinoma of the lung and DLBCL of the intrapulmonary lymph nodes. (ekjm.org)

Immunohistochemical analysis demonstrated that tumor cells were positive chromogranin A, synaptophysin, and CD56 (Figure 2 ). (hindawi.com)
The tumor cells were immunohistochemically positive for thyroid transcription factor -1. (jcancer.org)
10% of reactive tumor cells). (cdc.gov)
Membrane CD117 immunoreactivity in 5% or more tumor cells was documented in 30 (77%) large-cell neuroendocrine carcinomas and 18 (67%) small-cell carcinomas and 4 (7%) carcinoids, whereas cytoplasmic labeling was seen in 17 (44%) large-cell neuroendocrine carcinomas, 19 (70%) small-cell carcinomas, and 3 (5%) carcinoids. (elsevier.com)

Hürthle cell carcinoma a malignant Hürthle cell tumor . (thefreedictionary.com)
A high grade malignant neoplasm that arises from the lung and is characterized by the presence of large neuroendocrine cells. (mycancergenome.org)
This is most often the case when a pathologist examines a small amount of malignant cells or tissue in a cytology or biopsy specimen. (wikipedia.org)
After a long time, this change means that the normal control mechanisms for the growth and death of cells are no longer effective and a malignant tumor develops. (viewthegoals.com)
Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant . (wikipedia.org)

This report indicates total biopsy and immunohistochemistry are necessary for diagnosing large cell neuroendocrine carcinoma properly. (biomedcentral.com)
Repeated biopsy was performed and squamous cell carcinoma of the rectum was reported. (bvsalud.org)
Biopsy of the lesion revealed large cell neuroendocrine carcinoma of the cervix. (elsevier.com)
Here we present a case of 60 year old female who presented with left flank ulcer following chronic irritation from saree, biopsy was taken and it showed squamous cell carcinoma (SCC). (who.int)

Unlike pleomorphic carcinoma there is no evidence of any spindle cell component, atypical multinucleated and giant tumour cells. (histopathology-india.net)
A few of the less common types are pleomorphic, carcinoid tumor, salivary gland carcinoma, and unclassified carcinoma. (wikipedia.org)
Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus at least a 10% component of cells characteristic of more highly differentiated types (i.e. adenocarcinoma and/or squamous cell carcinoma). (wikipedia.org)
Large pleomorphic cells in a sparsely cellular sample. (papsociety.org)

Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients. (scicombinator.com)

Potentially curative radiotherapy for non-small-cell lung cancer in Norway: a population-based study of survival. (medscape.com)
Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy. (medscape.com)
Anal Carcinoma: impact of TN category of disease on survival, disease relapse, and colostomy failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial. (springer.com)
Because there is a significant difference in survival time for patients with large cell carcinoma (LCC), Travis et al. (scielo.br)
Non-small cell lung cancer survival rates are based on a five-year survival scale conducted from studies of people with this type of cancer. (facty.com)
Survival was significantly worse for patients with large cell neuroendocrine carcinomas than for patients with large cell carcinomas (P = .013). (elsevier.com)
001). Conclusion: Patients with large cell neuroendocrine carcinomas have a significantly worse survival after resection than patients with large cell carcinomas, even in stage I disease. (elsevier.com)
There was no association between CD117 immunoreactivity and survival in either small-cell carcinoma or large-cell neuroendocrine carcinoma patients. (elsevier.com)
There was a significant difference between the survival of patients with stage I large cell neuroendocrine carcinoma and that of patients with the same stage of other non-small cell lung carcinomas. (elsevier.com)
Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. (nature.com)

There is some dispute as to whether these constitute a distinct type of cancer or are merely a group of unusual squamous cell carcinomas and adenocarcinomas. (britannica.com)
With improved histopathologic procedures and the use of electron microscopy, most NSCLCs that would previously have been classified as large-cell carcinomas are identified as undifferentiated adenocarcinomas or, less frequently, as SCCs. (medscape.com)
Unlike adenocarcinomas that tend to be peripherally located in the lung, squamous carcinomas are more centrally located, with 60 to 80 % arising in the proximal portions of the tracheobronchial tree. (icnet.uk)

The diagnostic utility of zinc E-box 1 (ZEB1) transcription factor for identification of pulmonary sarcomatoid carcinoma in cytologic and surgical specimens. (harvard.edu)
Sarcomatoid carcinoma is a collective term for a heterogeneous group of NSCLCs that contain components of sarcoma or sarcoma-like cells. (icnet.uk)

We studied CD117 immunoreactivity in surgical specimens from 39 large-cell neuroendocrine carcinomas of stages I-III and 27 limited-disease small-cell carcinomas, 56 typical and atypical carcinoids of the lung, and 10 neuroendocrine tumorlets, including the membrane and cytoplasmic immunostaining patterns. (elsevier.com)

The research was jointly conducted and published by the teams of Dr. Jia Fan at Zhongshan Hospital, Fudan University, Dr. Hu Zhou at Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Dr. Daming Gao at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Clinical Proteomic Tumor Analysis Consortium (CPTAC), and Dr. Weiwei Shi at OrigiMed. (pharmiweb.com)
As a partner of the Clinical Proteomic Tumor Analysis Consortium (CPTAC), OrigiMed conducted a comprehensive proteogenomic analysis of HBV-related HCC from a Chinese cohort, and also was the first Chinese tumor precision medicine company to publish Chinese cancer population data in Cell . (pharmiweb.com)
To investigate the efficacy of tazarotene in a large series of BCCs, better to define the clinical advantages and the mechanisms of action in vivo. (ovid.com)
There are 4 clinical trials for large cell lung neuroendocrine carcinoma, of which 4 are open and 0 are completed or closed. (mycancergenome.org)
EGFR and SSTR2 are the most frequent gene inclusion criteria for large cell lung neuroendocrine carcinoma clinical trials [ 3 ]. (mycancergenome.org)
Nivolumab, pen-221, and etoposide are the most common interventions in large cell lung neuroendocrine carcinoma clinical trials. (mycancergenome.org)
The clinical characteristics and optimal treatment of patients with large cell carcinomas are not yet established. (elsevier.com)
A small proportion of patients with non-small cell lung cancer (NSCLC) experience objective clinical benefit after neoadjuvant programmed cell death 1 (PD-1) blockade. (medscape.com)
In addition, the correlations of pathologic response with various clinical factors, including PD-L1 expression, CD4+ and CD8+ T cells, regulatory T cells (Tregs), and intracavitary or extracavitary type, were analyzed to identify predictors of pathological response. (medscape.com)

High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience. (semanticscholar.org)

The RNA-seq profile of LCLC and other non-small cell lung carcinoma (NSCLC) was downloaded from Gene Expression Omnibus (GEO) and analyzed. (mdpi.com)
The most common types of NSCLC are squamous cell carcinoma , large cell carcinoma , and adenocarcinoma , but there are several other types that occur less frequently. (wikipedia.org)
[5] Non-squamous cell carcinoma almost occupy the half of NSCLC. (wikipedia.org)
According to the American Cancer Society (ACS), non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. (medicalnewstoday.com)
The majority of the treatment methods have focused on the establishment of new treatment options for non-small cell lung cancer (NSCLC). (medscape.com)

We also identified the LncRNA differentially expressed in LCLC compared to lung squamous carcinoma (LUSC) and Lung-adenocarcinoma (LUAD). (mdpi.com)
This study also finds tools to diagnose LCLC and differentiate LCLC with other Non-Small Cell Lung Cancer. (mdpi.com)
Non-small cell lung carcinoma is further divided into lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and undifferentiated large cell carcinoma (LCLC) [ 3 ]. (mdpi.com)

The aim of this study is to provide this investigational drug to patients who cannot be optimally treated with conventional therapies and to collect efficacy and safety data on the use of Metvix PDT in subjects with field actinic keratoses, large/multiple superficial basal cell carcinomas (BCCs) or Bowen's disease. (clinicaltrials.gov)

Non small cell lung cancer with a primary histology of squamous cell, large cell or adenosquamous carcinoma. (pfizer.com)
Cox proportional hazards model analysis incorporating the variables of age, sex, histology, and stage estimated the effect of large cell neuroendocrine carcinomas and mixed large cell neuroendocrine carcinomas on recurrence and death. (elsevier.com)
C. Photomicrograph of the histology shows groups of infiltrating cancer cells associated with keratin formation. (icnet.uk)
Endobronchial histology confirmed large cell undifferentiated carcinoma. (ispub.com)

The objective of this study was to report the outcome of surgical resection in patients with large cell neuroendocrine carcinomas. (elsevier.com)

Genetic subtypes of large cell neuroendocrine c. (nrs-science.nl)

abstract = "Little is known about CD117 prevalence and clinicopathological implications in pulmonary large-cell neuroendocrine carcinoma. (elsevier.com)
abstract = "A 33-year-old female patient underwent extended right lobectomy for a large tumor in the liver. (fujita-hu.ac.jp)

Non-small cell carcinoma subtypes include adenocarcinoma, squamous cell carcinoma, large cell carcinoma, and carcinoid tumor. (picmonic.com)

Hao H, Itoyama M, Tsubamoto H, Tsujimoto M, Hirota S. Large cell neuroendocrine carcinoma of the cervix associated with intestinal variant invasive mucinous adenocarcinoma. (springer.com)
We report a case of large cell neuroendocrine carcinoma of the uterine cervix. (bmj.com)
The female genital counterpart is aggressive and uncommon, with propensity to involve the cervix and ovary, the endometrium variant is seldom occurring and tends to be of a conventional small cell type (up to 60 cases). (alliedacademies.org)
12 A cervix carcinoma that has material basis in neuroendocrine tissue and is characerized by a diffuse, organoid, trabecular, or cord-like pattern of neoplastic cells with abundant cytoplasm, large nuclei, prominent nucleoli, and a high mitotic rate. (malacards.org)

Gastrointestinal small cell carcinoma and large cell carcinoma are usually diagnosed at an advanced stage, after they have spread to the lymph nodes or other organs. (mskcc.org)
There is a chance that, large cell carcinoma may spread to the chest wall and lymph nodes. (medeguru.com)
OR the tumor is larger than 5 cm and less than 7 cm, with no involvement of the nearby lymph nodes. (cancersupportcommunity.org)
The cancer has grown to be larger than 3 centimeters (cm) across and may have spread to the lymph nodes inside the lung but not to any distant organs. (medicalnewstoday.com)
Feb 12, 2012 will be my ten year anniversary surviving Small Cell Lung Cancer that spread to my stomach lymph nodes. (cancer.org)

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. (scielo.br)

Anatomy16

Organisms5

Diseases110

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes34

Disciplines and Occupations2

Information Science3

Health Care14

Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells. (1/382)

A case of synchronous double primary lung cancer with neuroendocrine features. (2/382)

Lung cancer incidence rates by histologic type in high- and low-risk areas; a population-based study in Osaka, Okinawa, and Saku Nagano, Japan. (3/382)

Ethnic differences in poly(ADP-ribose) polymerase pseudogene genotype distribution and association with lung cancer risk. (4/382)

p53 protein, EGF receptor, and anti-p53 antibodies in serum from patients with occupationally derived lung cancer. (5/382)

Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53. (6/382)

k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. (7/382)

Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer. (8/382)

Carcinoma

Carcinoma, Large Cell

Carcinoma, Squamous Cell

Carcinoma, Hepatocellular

Carcinoma, Neuroendocrine

Antigens, CD30

Carcinoma in Situ

Lymphoma, Large B-Cell, Diffuse

Carcinoma, Papillary

Immunohistochemistry

Carcinoma, Small Cell

Lung Neoplasms

Liver Neoplasms

Carcinoma, Ductal, Breast

Carcinoma, Basal Cell

Tumor Markers, Biological

Carcinoma, Bronchogenic

Adenocarcinoma

Prognosis

Carcinoma, Transitional Cell

Receptor Protein-Tyrosine Kinases

Neoplasm Staging

Cell Line, Tumor

Lymphoma, Primary Cutaneous Anaplastic Large Cell

Gene Expression Regulation, Neoplastic

Tumor Cells, Cultured

Carcinoma, Intraductal, Noninfiltrating

Carcinoma, Adenoid Cystic

Fatal Outcome

Skin Neoplasms

Carcinoma, Medullary

Lymphomatoid Papulosis

Neoplasm Invasiveness

Carcinoma, Lobular

Carcinoma, Adenosquamous

Neoplasm Proteins

Nasopharyngeal Neoplasms

DNA, Neoplasm

Thyroid Neoplasms

Immunoenzyme Techniques

Breast Neoplasms

Lymphoma, Non-Hodgkin

Chromosomes, Human, Pair 2

Lymphoma, Large-Cell, Immunoblastic

Carcinoma, Mucoepidermoid

Hodgkin Disease

Carcinoma, Non-Small-Cell Lung

Neoplasms, Multiple Primary

Lymphatic Metastasis

Lymphoma

Retrospective Studies

Lymphoma, T-Cell

Antigens, Neoplasm

Carcinoma, Endometrioid

Survival Rate

Head and Neck Neoplasms

Protein-Tyrosine Kinases

Chromosomes, Human, Pair 5

Carcinoma, Embryonal

Esophageal Neoplasms

Mouth Neoplasms

Survival Analysis

Carcinoma, Merkel Cell

Bronchial Neoplasms

Antineoplastic Agents

Carcinoma, Ductal

Lymphoma, B-Cell

Neoplasm Metastasis

Neoplasm Recurrence, Local

Biopsy

Neoplasm Transplantation

Mice, Nude

Stomach Neoplasms

Treatment Outcome

RNA, Messenger

Ovarian Neoplasms

Combined Modality Therapy

Translocation, Genetic

Adrenocortical Carcinoma

Colonic Neoplasms