The type species of CARDIOVIRUS causing encephalomyelitis and myocarditis in rodents, pigs, and monkeys. Infection in man has been reported with CNS involvement but without myocarditis.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Infections caused by viruses of the genus CARDIOVIRUS, family PICORNAVIRIDAE.
Ribonucleic acid that makes up the genetic material of viruses.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
A subspecialty of internal medicine concerned with the study of neoplasms.
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A 7-carbon keto sugar having the mannose configuration.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mostly trees and shrubs growing in warm areas.
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC
A non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems. (J Neurochem 1993;60(4):1498-504)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
A plant genus of the family RANUNCULACEAE. Members contain cernuosides and other oleanane and hederagenin saponins.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Tumors or cancers of the KIDNEY.
Excision of kidney.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.
RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibodies produced by a single clone of cells.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Organic or inorganic compounds that contain the -N3 group.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Stipends or grants-in-aid granted by foundations or institutions to individuals for study.
The common orally transmitted traditions, myths, festivals, songs, superstitions, and stories of all peoples.
An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.
A body of stories, the origins of which may be unknown or forgotten, that serve to explain practices, beliefs, institutions or natural phenomena. Mythology includes legends and folk tales. It may refer to classical mythology or to a body of modern thought and modern life. (From Webster's 1st ed)

A new concept of the function of elongation factor 1 in peptid chain elongation. (1/97)

An entirely new model for the mechanism of elongation factor 1 (EF-1) function is presented. Experiments in which mixtures of [3H]EF-1, ribosomes from Drebs II ascites cells and various additional co-factors were analyzed by chromatography on Sepharose 6B, show that EF-1 binds to the ribosome early in the translation process and remains bound on the ribosome during translation. Optimal EF-1 binding occurs on polynucleotide-programmed ribosomes carrying a tRNA in their P-site. On the other hand it was clearly shown that EF-2 attached at each translocation event and was then released before a new Phe-tRNA could be bound.  (+info)

Control of the mRNA for hepatic tryptophan oxygenase during hormonal and substrate induction. (2/97)

Glucocorticoid hormones increase the level of hepatic tryptophan oxygenase (EC; L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) by increasing its rate of synthesis. Studies were performed to determine whether this induction is mediated by controlling the level of the mRNA for tryptophan oxygenase of by changing the translational efficiency of a fixed level of mRNA. Activity of tryptophan oxygenase mRNA was quantitated in a Krebs ascites cell-free, protein-synthesizing system, supplemented with tRNA and rabbit reticulocyte initiation factors. De novo synthesis of the protomeric unit(s) of the enzyme was a linear function of the amount of mRNA added. Time course and dose-response studies in which the enzyme level and mRNA activity in livers from rats injected with inducing doses of hydrocortisone were compared indicate that the induction of this enzyme is accompanied by a proportional increase in the level of its mRNA. This was true for mRNA isolated from total liver as well as from cytoplasmic polysomes. Induction of the enzyme by its substrate, tryptophan, however, was not accompanied by a parallel increase in mRNA activity.  (+info)

Isolation of rabbit reticulocyte initiation factors by means of heparin bound to sepharose. (3/97)

Passage of cell-free extracts of rabbit reticulocytes through heparin-Sepharose affinity columns results in the loss of the ability of the effluent to initiate protein synthesis. This is shown by the loss of response to added rabbit globin mRNA or to inhibitors of initiation of protein synthesis, such as heparin and aurin tricarboxylic acid, and by recovery of initiation activity by addition of protein retained and subsequently eluted from the columns. The effluent retains, however, the ability to elongate protein chains. Only 0.8% of the applied cell extract protein binds to heparin-Sepharose columns. This bound protein, which can be recovered by increasing the salt concentration of the eluting buffer, has initiation factor activity equal to that of a crude initiation factor preparation obtained from rabbit reticulocyte ribosomes by extraction with 0.5 M KCl. The protein patterns on polyacrylamide gels of the initiation factors prepared by either method are very similar and indicate a protein mixture, which may represent a complex. These data confirm that heparin interacts specifically with initiation factos, and indicate that heparin-Sepharose chromatography will simplify procedures for the preparation of initiation factors.  (+info)

Endogenous messenger ribonucleic acid-directed polypeptide chain elongation in a cell-free system from the yeast Saccharomyces cerevisiae. (4/97)

An in vitro protein-synthesizing system from the yeast Saccharomyces cerevisiae has been made by a modification of the procedure for preparation of the Krebs ascites system. The protein synthetic activity is directed by endogenous messenger. Amino acid incorporation occurs over a broad range of magnesium and potassium concentration, being maximal at 6 and 85 mM, respcetively. The activity of this in vitro system is due to the elongation of polypeptides whose synthesis was initiated in vivo. The cell extract does not initiate synthesis with endogenous messenger ribonucleic acid (RNA), since 1 muM pactamycin, which blocks initiation on prokaryotic or eukaryotic ribosomes invitro, fails to decrease amino acid incorporation. Ten micromolar cycloheximide, however, inhibits incorporation by 87%. Moreover, this system is not stimulated by rabbit reticulocyte polysomal RNA, which directs the synthesis of hemoglobin in extracts of Krebs ascites cells. The translation of this messenger is not masked by high endogenous incorporation, because autoradiography of sodium dodecyl sulfate-polyacrylamide gels containing [35-S]methionine-labeled products shows that no hemoglobin is made. Preincubation of this system, which reduces the high endogenous incorporation by 80%, does not increase its capacity to be stimulated by either rabbit reticulocyte RNA or yeast polyriboadenylic acid-containing RNA. Polyuridylic acid, however, does stimulate polyphenylalanine incorporation. The failure of the yeast lysate to be stimulated by or to translate added natural messenger RNA, its insensitivity to low levels of pactamycin but inhibition by cycloheximide, and its relatively high magnesium optimum (the same as that for polyuridylic acid) suggest that it elongates but does not initiate polypeptide chains.  (+info)

The binding of tritiated elongation factors 1 and 2 to ribosomes from Krebs II mouse ascites tumor cells. (5/97)

Tritiated elongation factors 1 and 2 (EF-1 and EF-2) were obtained from Krebs II ascites cells which had been grown in mice injected with radioactive amino acids. The highly purified factors were sufficiently radioactive to be used in a study of the interactions between ribosomes and elongation factors. The following results were obtained. 1. EF-1 binding to ribosomes requires the presence of a polynucleotide, an aminoacyl-tRNA specified by the latter and a guanosine nucleotide carrying three phosphate groups. The hydrolysis of the GTP molecule involved in the binding reaction leads to the immediate release of EF-1. If GTP is replaced by Guo-5'-P2-CH2-P the factor remains bound to the ribosome and can be detected by sucrose gradient centrifugation techniques. 2. Likewise EF-2 binding to ribosomes can only be detected in the presence of GUO-5'-P2-CH2-P. 3. The affinity of ribosomes for EF-2 appears to be higher than for EF-1: PREINCUBATION OF RIBOSOMES WITH EF-2 inhibits the subsequent attachment of EF-1 almost completely. EF-1 prebound to ribosomes in the presence of GUO-5'-P2-CH2-P, POLY(URIDYLIC ACID) AND Phe-tRNA-Phe is partially removed from the ribosomes together with Phe-tRNA during a second incubation with EF-2. 4. Although EF-2 binding to ribosomes precludes any stable association between ribosomes and EF-1 it does not prevent the insertion of aminoacyl-tRNA into the ribosomal A-site. The attachment of aminoacyl-tRNA under these conditions enhances the binding of EF-2 to the ribosome. 5. The antibiotic showdomycin strongly inhibits the attachment of EF-1 to ribosomes and to a lesser degree impairs the binding of EF-2. 6. A-site ribosomes display a strong preference for the attachment of EF-2 and bind EF-1 only very poorly. The reverse is true for P-site ribosomes which are good substrates for the binding of EF-1 and bind EF-2 less efficiently than A-site ribosomes. These results and a number of additional findings made in this and in previous studies are discussed in the general context of the structure and function of mammalian elongation factors 1 and 2.  (+info)

Isolation and characterization of collagen messenger RNA*. (6/97)

Chick embryo collagen-synthesizing polysomes were isolated by differential centrifugation. RNA extracted from these particles was chromatographed in oligo(dT)-cellulose solumns and the mRNA thus obtained characterized as collagen mRNA by its electrophoetical mobility in acrylamide gels (equivalent to 1.05 x 10-6 daltons) and its effect upon a cell-free system derived from Krebs ascites tumor cells. The incorporation of 3H-proline was markedly dependent upon rabbit reticulocyte initiation factors and inhibited by initiation inhibitors such as aurintricaboxilate and pyrocatechol violet. The incorporation product was characterized as collagen by its lack of tryptophan, digestibility by purified bacterial collagenase, and by its co-chromatography with unlabled chick collagen in Sephadex G-200 and CM-cellulose columns.  (+info)

Messenger activity of RNA transcribed in vitro by DNA-RNA polymerase associated to vaccinia virus cores. (7/97)

The coding properties of RNA transcribed in vitro by purified vaccinia cores have been investigated using Krebs ascites tumor cells, L cells, and reticulocyte lysates. Six to 10 proteins synthesized in vitro are separated on polyacrylamide gels by electrophoresis in the presence of sodium dodecyl sulfate. Their molecular weights vary from 10,000 to 44,000. The electrophoretic behavior of these proteins is similar to that of early proteins isolated from infected L cells. The tryptic peptide analysis of one of these proteins indicates similarity in amino acid sequences. These results show fidelity of both in vitro transcription and molecular weight above 44,000 are synthesized in vitro does not seem due to a competition between 12S mRNA synthesized in excess and RNA of a higher sedimentation coefficient present in a lower amount.  (+info)

Assay of protamine messenger RNA from rainbow trout testis. (8/97)

A low molecular weight RNA fraction possessing protamine mRNA activity was prepared from rainbow trout testis polysomes. Addition of low molecular weight RNA to a Krebs II ascites S-30 cell-free protein synthesis system strongly stimulated [14C]arginine incorporation into acid-insoluble material. This stimulation was completely abolished by 10-4 M aurintricarboxylic acid, an inhibitor of eukaryotic protein synthesis at the level of initiation. Starch gel electrophoresis showed that labeled arginine was incorporated in vitro into products identical with both authentic protamine and histones as found previously (Gilmour, R. S., and Dixon, G. H. (1972) J. Biol. Chem. 247, 4621-4627). The 4 to 6 S RNA fraction, isolated from the polysomal low molecular weight RNA by sucrose gradient fractionation, enhanced the incorporation of [14C]arginine into acid-insoluble material and when this product was examined by starch gel electrophoresis, it co-migrated with authentic rainbow trout protamine.  (+info)

Nolan, R D.; Grasmuk, H; Hogenauer, G; and Drews, J, Elongation factor 1 from krebs ii mouse ascites cells. Interaction with guanosine nucleotides and aminoacyl-trna. (1974). Subject Strain Bibliography 1974. 1110 ...
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Study more efficiently for Pharmakologie - Krebs at Universität Tübingen ➤ Millions of flashcards & summaries ⭐ Get started for free with StudySmarter ✔
Nykanen, A., Holmstrom, E. J., Tuuminen, R., Krebs, R., Dhaygude, K., Kankainen, M., Jokinen, J. J., Lommi, J., Helantera, I., Raisanen-Sokolowski, A., Syrjala, S. O. & Lemstrom, K. B., 20 elokuuta 2019, julkaisussa : Circulation . 140, 8, s. 627-640 14 Sivumäärä. Tutkimustuotos: Artikkelijulkaisu › Artikkeli › Tieteellinen › vertaisarvioitu ...
Abilities: Genius-level intelligence, Ph.D in Psychology, Doctor of veterinary medicine.. Mousey Mitsi Murina grew up with her nose in the books. Ironically though, her parents were both lowly minions for hire; Iron Head Harry and Quick Draw Doris. Harry and Doris worked at different times for a variety of masked supervillains, such as: being tricksters under the Trixtress; cooking up trouble as short order cooks for Chef Pasty; and criminal Klowns under the Black Hat among other various nefarious occupations. So, it was just as surprising to Harry and Doris as it was to everyone else that their child Mitsi was a natural-born genius.. True to their criminal natures, Harry and Doris saw Mitsis brilliance as a vehicle to make themselves rich. They used their underworld friends and influence to get Mitsi the best tutors and into the best schools. Her parents relentlessly drove her to study non-stop. Mitsi had no time for friends or any kind of social life. Her every waking moment was spent ...
Highly purified RNase H (RNA·DNA hybrid ribonucleotidohydrolase, EC from calf thymus was used to specifically remove the poly(A) sequences of purified rabbit globin mRNA after its hybridization with poly(dT). The deadenylylated globin mRNA was repurified by a one-step procedure including a nitrocellulose column. The poly(A) size and the content of unmodified mRNA were determined by hybridization with [(3)H]-poly(U), and it could be shown that the RNase H digestion method effectively removes this terminal poly(A) sequence. No difference in activity was found between mRNAs with and without poly(A) to initiate, elongate, terminate, and release newly synthesized globin chains in exogenous-mRNA-dependent, cell-free, protein-synthesizing systems from wheat embryo, ascites Krebs II cells, and rat liver. Furthermore, poly(A)-free globin mRNA competed with the same efficiency as authentic globin mRNA against chick ovalbumin mRNA when translated under total mRNA saturation conditions. It is ...
A protein factor that specifically binds to the 5-untranslated region of encephalomyocarditis virus (EMCV) RNA has been found in extracts of ascites carcinoma Krebs-2 cells. This was done using UV-irradiation on extracts supplemented with in vitro synthesized 32P-labelled transcripts followed by an …
Scoli de soferi Timisoara este un site in care se promoveaza scoala de soferi Krebs din Timisoara, activitatile acestei scoli de soferi,in care se poate invata parcarea cu fata,parcarea laterala,parcarea cu spatele,plecarea in rampa,conducerea de noapte,scoli de soferi timisoara conduita preventiva,mecanica scoli de soferi si multe altele in vederea promovarii examenului auto si a obtinerii permisului de conducere.Scoli moto si examen moto Timisoara. Scoli de soferi Timisoara.
Perfekte Krebs Stock-Fotos und -Bilder sowie aktuelle Editorial-Aufnahmen von Getty Images. Download hochwertiger Bilder, die man nirgendwo sonst findet.
Mehr Prävention im Leben - eine Qual? - Nein, mehr Qual-ität für`s Leben - Krebs und Prävention - Prävention, Einflussfaktoren und Krebsrisiken
Lee, H; Richards, V; and Furst, A, Change in dry mass of ascites cells after hn2 treatment. Abstr. (1961). Subject Strain Bibliography 1961. 565 ...
Oh once again neej you seem to be a very confused soul… Hopefully you are intelligent get lost but I sense you arent that smart. Just because Distributed is in the name means nothing. Ill explain so people like you that dont grasp much hopefully wont make a fool of themselves a third time. Or maybe you are going for three times in a row?. My comment is in relation to the total power behind the DDoS attack as listed in the chart at the top of the article. The Attack barely touched over 2 GBps. However, Brian seems to be on the lucky end because the people upset at him dont have much of a backbone and had to use many hosts to reach these speeds.. Where-as it wouldnt be difficult for certain parties to hit just as hard with no more than two un-metered GB lines. Now lets imagine if said people actually got annoyed at someone they of course wouldnt use only two GB boxes. It is simply a statement as to how pitiful this attack was that it could be overpowered with a meager 2 hosts. Back to my ...
The major difference between anaerobic and aerobic conditions is the requirement of oxygen. Anaerobic processes do not require oxygen while aerobic...
Biology Lecture - 38 - Finishing the Krebs Cycle tutorial of Biology I course Online Tutorials. You can download the course for FREE !
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Inflammatory reactions mediated by oxidative stress (OS) have been implicated in the deterioration of oocyte quality, which may lead to subfertility. Oxidative stress generated from enhancement of activated macrophages secondary to an inflammatory response are the major source of reactive oxygen species (ROS) such as superoxide (O2•−), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and hypochlorous acid (HOCl), as well as, the pro-inflammatory enzyme myeloperoxidase (MPO). Previously, it has been shown that these ROS have deleterious effect on oocytes; however the link between inflammation through macrophage activity and oocyte quality remains unclear. In this work, we investigated: 1) the mechanism through which direct exposure of ROS and MPO, or through their generation by activated macrophages, deteriorate oocyte quality and whether melatonin (MLT), a potent MPO inhibitor and ROS scavenger, can protect oocyte quality; and 2) the mechanism through which MLT inhibits MPO catalytic activity.
TY - CHAP. T1 - Chapter 10 M-T7. Measuring Chemokine-Modulating Activity. AU - Bartee, Mee Y.. AU - Dai, Erbin. AU - Liu, Liying. AU - Munuswamy-Ramanujam, Ganesh. AU - Macaulay, Colin. AU - McIvor, Dana. AU - McFadden, Grant. AU - Lucas, Alexandra R.. PY - 2009/5/14. Y1 - 2009/5/14. N2 - Chemokines are important for activation of a host of cellular immune and inflammatory responses including cell signaling, activation, and communication. M-T7, a myxoma virus protein, inhibits the activity of chemokines by direct binding to chemokines and/or with glycosaminoglycans (GAGs). To study the effects of this chemokine-modulating protein (CMP), we use a variety of in vitro and in vivo techniques to evaluate M-T7 inhibition of inflammatory cells. To quickly analyze the effects of M-T7, changes in cell adhesion and membrane fluidity are measured as well as cell migration in mouse ascites. For more physiological analyses, an aortic transplant model in rodents is used to assess change in inflammatory cell ...
Definition of Encephalomyocarditis virus with photos and pictures, translations, sample usage, and additional links for more information.
Krebs worked as a doctor in the Altona hospital and at the University of Freiburg. At the University of Freiburg he researched the urea cycle.. Because he was Jewish, Krebs could not be a doctor in Germany. In 1933 he moved to England. He worked at Cambridge with Sir Frederick Gowland Hopkins. In Cambridge he researched biochemistry. In 1945 he became a Professor (teacher) at the University of Sheffield.. In 1954 he became a professor in Oxford. After his retirement, Krebs continued work at the Radcliffe Infirmary until his death. He was a fellow of Trinity College in Oxford.. ...
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Free Online Library: Succinate retention: the core Krebs dysfunction in immune-inflammatory disorders. by Townsend Letter; Health, general Chronic diseases Immune response Health aspects Inflammation Development and progression Krebs cycle Metabolites Succinic acid
Support healthy heart function* Why are Krebs minerals important? They can more easily support many functions in the body that require mineral replenishment:* Supplementation with Krebs cycle minerals is often used to enhance the production of energy at a cellular level, in the mitochondria.* Sustainable energy
Definition of Encephalomyocarditis with photos and pictures, translations, sample usage, and additional links for more information.
So are u saying avoid the Glisodin if you have gluten issues but the Energy Enzymes is ok? I have been on a desperate search for energy for years. Do...
Die Medizin ist auf der Suche nach Hinweisen, die frühzeitig auf komplexe Krankheiten hindeuten. Um solche sogenannten Biomarker zu finden, hat das ETH-Spinoff Scailyte eine Software entwickelt, die Millionen von einzelnen Zellen durchforstet. ...
NSE, or Enolase 2 (gamma, neuronal), is a human gene encoded by ENO2. It may also be known as: Gamma-enolase; Enolase 2; Neural enolase; Neuron-specific enolase; Gamma-enolase ; HEL-S-279. The encoded protein is an enzyme with an amino acid length of 434 and a mass of 47.3 kDa. Other isoforms may exist. NSE is a member of the Enolase family. Homologs of this gene exist in other organisms, including: Mouse, Rat.. Abbkine NSE Monoclonal Antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous NSE proteins. Its suitable to be applied in WB, IHC and IF. Its verified to react with human, mouse and rat. The concentration of this monoclonal antibody is 1mg/ml.. Our group purchased Abbkine NSE monoclonal antibody for detecting NSE proteins in paraffin-embedded Human-colon tissue sections. Our sample were incubated with Abbkine NSE monoclonal antibody (diluted at 1:200) overnight at +4°C. The sensitivity of the antibody was ...
As I said above the Krebs cycle was discovered by Hans Adolf Krebs in the year of 1937. The Krebs cycle occurs in an aerobic organism that is part of the metabolic pathway where it converts carbohydrates into water and carbon dioxide for usable energy in cellular respiration. The Krebs cycle starts with a glucose molecule and that glucose molecule is broken up due to the process of glycolysis into two pyruvates or pyruvic acids. Glyciolysis occurs in the cytoplasm. Remember, the Krebs cycle must go around two times to create one PGAL or G3P (glyceroldeyhde 3 phosphate). The next step of the Krebs cycle is the pyruvate joins with CoA, or coenzyme A, and forms a two carbon molecule called an acetyl group. After this acetyl group is formed, it joins with a four carbon molecule called oxaloacetic acid forming a six carbon molecule called citric acid. This is why the Krebs cycle is also referenced as the citric acid cycle. Throughout theKrebs cycle carbon dioxide molecules are released. For example, ...
Edwin G. Krebs. Edwin G. Krebs is a soft-spoken, understated Midwesterner, but theres one thing that gets his goat. Since he turned his attention from medicine to biochemistry, people have been asking him about his cycle. They confuse him with Sir H.A. Krebs, the British scientist who won the Nobel Prize in 1953 for elucidating the metabolic Krebs (or tricarboxylic acid) cycle.. One person who made this mistake was the chairman of a clinical department at the UW School of Medicine in 1948, when Krebs started as an assistant professor of biochemistry. I must confess that I didnt correct his wrong impression, says Krebs. I was so uneasy about my status then that I enjoyed being treated with such deference, even for the wrong reason.. In 1992, Krebs and Edmond H. Fischer were awarded the Nobel Prize in physiology or medicine for figuring out how reversible phosphorylation works as a switch to activate proteins and regulate various cellular processes. Their discovery was a key to unlocking ...
Infection with L. major is a well-characterized model in which differentiation of class II-restricted T cells into the two mature helper subsets is required for expression of the resistant and susceptible disease phenotype. Ii is required for stable expression of surface class II molecules and, as predicted, cells from Ii −/− mice have substantially lower amounts of surface class II that do not assume the compact conformation that characterizes stable peptide binding ((17), (28), (29)). The major immunologic consequences are twofold: a severely compromised ability to present processed antigens via the class II pathway, and a quantitatively and qualitatively altered CD4+ population due to aberrant selection by thymic epithelial cells unable to present self peptides in a normal manner ((40), (41)). Despite this drastic effect on the class II-dependent immune response, we could discern little consequence to the host in generating either Th1 or Th2 responses to L. major. How might we explain ...
What is the difference between Krebs Cycle and Glycolysis? Krebs cycle (citric acid cycle / TCA cycle) occurs inside mitochondria of eukaryotes. Glycolysis
Kitar Krebs, juga dikenali sebagai kitar asid trikarboksilik, kitar asid sitrik, atau jarang-jarang sekalisebagai kitaran Szent-Györgyi-Krebs[1][...
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In this Behind the paper: blog, I discuss the rationale for searching non-enzymatic, metabolism like chemical networks, and the circumstances that led to their discovery. I can also not omit to also make reference to some of the original reactions to this work,
I talk to real life cyberheist victims every week, companies that have lost well into six figures because some employee clicked a link they shouldnt have. How many of these victims were running antivirus? All of them. Guess how many had detections when they infected their systems? None. Im publishing a story later this week about a victim that clicked a link 4 days after it was emailed to her and her companys AV *still* didnt detect it. I continue to look for and encourage several different, unbiased researchers who arent getting paid to do the kind of testing needed to see just how much attention any of us should pay to what the antivirus companies - or their apologists - say about anything. I think Im close to making that happen with a similar month-long study of this same type of malware. Stay tuned. For anyone interested, about two years ago I wrote about a study from NGS Software, which actually did do some of the testing Ive been advocating, but on a shorter term scale. They found ...
CD4+ T cells play an important role in the initiation of an immune response by providing help to other cells. Among the helper T subsets, interferon-γ (IFN-γ)-secreting T helper 1 (Th1) and IL-17-secreting T helper 17 (Th17) cells are indispensable for clearance of intracellular as well as extracellular pathogens. However, Th1 and Th17 cells are also associated with pathogenesis and contribute to the progression of multiple inflammatory conditions and autoimmune diseases. In the current study, we found that BJ-1108, a 6-aminopyridin-3-ol analogue, significantly inhibited Th1 and Th17 differentiation in vitro in a concentration-dependent manner, with no effect on proliferation or apoptosis of activated T cells. Moreover, BJ-1108 inhibited differentiation of Th1 and Th17 cells in ovalbumin (OVA)-specific OT II mice. A complete Freunds adjuvant (CFA)/OVA-induced inflammatory model revealed that BJ-1108 can reduce generation of proinflammatory Th1 and Th17 cells. Furthermore, in vivo studies showed that
Mouse monoclonal anti-human Transferrin antibody DEAE chromatography purified Isotype IgG1 Source Mouse ascites Immunogen Recombinant human Transferrin antigen purified from cellculture supernatant Purity |95% by HPLC and SDS-PAGE Application for CEA quantitativeassays by EIA Storage
1. The tumour cells were starved in a solution lacking Na+ and then transferred to a Ringer solution containing 2mm-sodium cyanide, 150m-equiv. of Na+/l. and 10m-equiv. of K+/l. Such cells were depleted of ATP and contained an endogenous pool of various amino acids equivalent to a 26mm solution. 2. At 4min. after the transfer the cellular Na+ content had increased by about 100% and roughly an equivalent amount of K+ had left the cells. 3. Under these conditions [14C]glycine was absorbed from an 11mm solution and reached the same cellular concentration by about 4min. The pool size increased by approximately the same amount (ΔGly), so glycine did not simply exchange with the endogenous components. 4. After 4min. with glycine, the cells contained about 20% more Na+ (ΔNa+) than the control and about 10% less K+ (ΔK+). The mean values of ΔNa+/ΔGly and ΔK+/ΔGly from five experiments were respectively 0·90±0·11 and 0·62±0·11equiv./mole. 5. A further indication that these two ratios were ...
Chiropractor, Eric A. Krebs DC, located in Austin, TX. We are a Family Wellness Clinic. We specialize in Pediatric care and care during pregnancy. Dr. Krebs is certified in the
Im Forschungsverbund forimmun kooperieren 12 Gruppen aus 5 verschiedenen, bayerischen Universitäten mit 11 Industriepartnern aus der Biotech-Branche. Ziel ist die Entwicklung neuer immuntherapeutischer Konzepte gegen Krebs, Infektionen, Allergien und Autoimmunerkrankungen. Der Forschungsverbund will dabei so unterschiedliche Bereiche wie Onkologie, Infektionsbiologie, Immunologie und Genomforschung vernetzen. Die Bayerische Forschungsstiftung fürdert den Verbund mit 2,5 Mio. Euro für eine Laufzeit von 3 Jahren.Infektions- und Krebserkrankungen verursachen weltweit über die Hälfte aller Todesfälle. Konventionelle Therapiekonzepte wie der Einsatz von Antibiotika bei Infektionen und Chemotherapie oder Bestrahlung bei Krebs stoßen immer wieder an ihre Grenzen. Kritisch ist vor allem das vermehrte Auftreten von Resistenzen und Mutationen bei vielen Infektionserregern und Tumorzellen. Sie sind so in der Lage sich immer wieder einer Behandlung zu entziehen. Aus diesen Gründen sind neue Strategien zur
Das Nationale Centrum für Tumorerkrankungen (NCT) Heidelberg vereinigt Patientenversorgung, Krebsforschung und Krebsprävention unter einem Dach, um alle für den Kampf gegen Krebs relevanten Aspekte zu berücksichtigen.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Shop Running On The Krebs Cycle (Science Humour) Coffee Mug created by wordsunwords. Personalise it with photos & text or purchase as is!
This short slide set explains the uniformity of the Krebs cycle across all life using evolutionary theory. Save the slide set to your computer to view the explanation and notes that go along with each slide.. Author/Source: ...
Tryptophan oxygenase (tryptophan 2,3-dioxygenase) activity increases immediately before the initiation of actinomycin D production by Streptomyces parvullus. We have attempted to discern whether this increase is due to a release from catabolite repression or to the synthesis of an inducer substance. The standard culture medium (glutamic acid-histidine-fructose medium) used in antibiotic production studies with S. parvullus contains l-glutamate as a major constituent. l-Glutamate is almost totally consumed before the onset of actinomycin D synthesis. The addition of 10 mM l-glutamate at this stage completely abolished actinomycin D production as well as tryptophan oxygenase synthesis. Fourteen amino acids were tested for a similar effect. Of these, l-glutamate and l-aspartate had the most dramatic effect on tryptophan oxygenase and beta-galactosidase (beta-d-galactosidase), another inducible enzyme. Standard glutamic acid-histidine-fructose medium, preincubated for 23 h to remove l-glutamate, allowed the
TY - CHAP. T1 - Cell-free Synthesis of Macromolecular Complexes. AU - Botte, Mathieu. AU - Deniaud, Aurelien. AU - Schaffitzel, Christiane. PY - 2016/5/11. Y1 - 2016/5/11. N2 - Cell-free protein synthesis based on E. coli cell extracts has been described for the first time more than 50 years ago. To date, cell-free synthesis is widely used for the preparation of toxic proteins, for studies of the translation process and its regulation as well as for the incorporation of artificial or labeled amino acids into a polypeptide chain. Many efforts have been directed towards establishing cell-free expression as a standard method for gene expression, with limited success. In this chapter we will describe the state-of-the-art of cell-free expression, extract preparation methods and recent examples for successful applications of cell-free synthesis of macromolecular complexes.. AB - Cell-free protein synthesis based on E. coli cell extracts has been described for the first time more than 50 years ago. To ...
Buy, download and read Food: A Very Short Introduction ebook online in EPUB or PDF format for iPhone, iPad, Android, Computer and Mobile readers. Author: John Krebs. ISBN: 9780191637001. Publisher: OUP Oxford. In this Very Short Introduction, Prof Lord John Krebs provides a brief history of human food, from our remote ancestors 3 million years ago to the present day. By looking at the four great transitions
Edwin Gerhard Krebs (lahir di Lansing, Iowa, Amerika Serikat, 6 Juni 1918 - meninggal di Seattle, Washington, Amerika Serikat, 21 Desember 2009 pada umur 91 tahun) ialah seorang biokimiawan Amerika Serikat. Ia belajar kedokteran dan mendapatkan gelar PhD dari Universitas Washington, Missouri. Ia kemudian menjadi profesor pembantu biokimia di perguruan tinggi yang sama. Kerja samanya dengan Edmond Fischer membuatnya memenangkan Nobel Fisiologi atau Kedokteran pada tahun 1992 karena berhasil menggambarkan bagaimana fosforilasi reversibel bekerja sebagai saklar untuk mengaktifkan protein dan mengatur berbagai proses seluler. ...
Majid Ali, M.D. Succinate Circa 2004 Table 1. The Frequency of Increased* Urinary Excretion of Metabolites of the Krebs Cycle in 236 Patients with Dysoxygenosis Citric acid Succinic acid Aconitic acid Fumaric acid 2-oxo-glutaric acid 196 40 26 1 0 * Increases beyond the laboratory range for the general population. Levels of acids measured in…
Aspects of metabolic regulation : papers contributed by some of his students and colleagues to mark the 80th birthday of H.A.Krebs, 25th August ...
Volume 1 ml (1 mg/ml) Description Anti-GFP (Green Fluorescent Protein) Tag (GF28R) Monoclonal Antibody Clonality | Host Species | Isotype GF28R | Mouse | IgG2b Immunogen GFP from the jellyfish Aequorea Victoria N-terminal peptide-KLH conjugates Specificity Recognizes native and denatured forms of GFP and its variants such as: EGFP, YFP, EYFP, and CFP Purification Protein A affinity chromatography from mouse ascites fluid Application Dot, ELISA, IP, IS, WB Sensitivity WB (with ECL): 1-10ng of purified GFP or GFP fusion proteins Working Condition WB (with ECL): 1:1000-3000 dilution (incubate for 1 hour at room temperature) IS: 1:500-2000 dilution For best results with other assays (e.g.: Dot, ELISA, IP, etc), please determine optimal working dilution by titration test Storage Store at -20 C for 2 years or more. Centrifuge after first thaw to maximize product recovery. Aliquot to avoid repeated freeze-thaw cycles. Store aliquots at 4 C (add 0.05 NaN3) for several days to weeks Images Fig. 1:1000 (1 g/mL)
This coherent text translates the methods of statisticians into ecological English so that students may readily apply these methods to the real world. Ecological Methodology, Second Edition provides a balance of material on animal and plant populations. It teaches students of ecology how to design the most efficient tests in order to obtain maximum precision with minimal work. The first part of the text focuses on biological and technical issues in statistical methodology. Students learn about advances that have been made in designing better sampling devices, along with the techniques and equipment used for sampling. The second part deals with creating solid statistical design, and presents all methods that are well-known to statisticians in a language and context that students will easily understand.
Hydrolysis of the acetyl group from the 1-alkyl-2-acetyl and 1-alkyl-3-acetyl substrates occurs at apparently identical rates. The enzyme from Erlich ascites cells is membrane-bound. It differs from lipoprotein lipase (EC since 1,2-diacetyl-sn-glycerols are not substrates. It also differs from EC, 1-acetyl-2-alkyl-glycerophosphocholine esterase ...
o Suchia Krebs, 1976 [1974?] sensu Parrish, 1993 ,?- †Dongusuchus efremovi Sennikov, 1988 ,?- †Energosuchus garjainovi Ochev, 1986 ,?- †Euscolosuchus olseni Sues, 1992 ,?- †Jaikosuchus magnus (Ochev, 1979) [Chasmatosuchus magnus Ochev, 1979] ,?-o †Tsylmosuchus Sennikov, 1990 , ,-- †T. jakovlevi Sennikov, 1990 , ,-- †T. samariensis Sennikov, 1990 , ,-- †T. donensis Sennikov, 1990 , `-- †T. sp. [Sennikov, 1990] [NE Europe] ,?- †Vytshegdosuchus zheshartensis Sennikov, 1988 ,-- †Saurosuchus galilei Reig, 1959 `--+-- †Batrachotomus kupferzellensis Gower, 2000? ,--o †Prestosuchidae Romer, 1966 sensu Parrish, 1993 , ,?- †Ticinosuchus ferox Krebs, 1965 [Mandasuchus Charig, 1957] , ,-- †Yarasuchus deccanensis Sen, 2005 , ,-- †Tikisaurus romeri Chatterjee & Majumdar, 1987 , `--o †Prestosuchus Huene, 1942 , ,-- †P. chiniquensis Huene, 1942 , `?- †P. loricatus Huene, 1942 [cospecific with P. chiniquensis sensu Parrish, 1993] ,?- †Rauisuchidae Huene, 1942 ...
1919 is a American Pale Wheat Ale style beer brewed by Choc Beer Co. / Petes Place in Krebs, OK. 3.36 average with 201 ratings, reviews and opinions.
The accuracy and stability of caffeine and halothane concentrations in liquid Krebs medium were examined. Caffeine-Krebs Ringers solution in incremental concentrations from 0.25 to 10 mM (N = 8 for each concentration) was serially assayed over a thr
Das Nationale Centrum für Tumorerkrankungen (NCT) Heidelberg vereinigt Patientenversorgung, Krebsforschung und Krebsprävention unter einem Dach, um alle für den Kampf gegen Krebs relevanten Aspekte zu berücksichtigen.
The truncated Krebs cycle and other metabolic ramifications of mitochondrial membrane cholesterol". The Journal of Biological ... lymphocyte reactivity and death in patients with bronchial carcinoma". Journal of Cancer Research and Clinical Oncology. 115 (6 ... citric acid cycle, malate-aspartate shuttle Krebs, HA; Bellamy D (1960). "The interconversion of glutamic acid and aspartic ... "Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma". Cancer Research. 52 (5 ...
The mitochondrial isoenzyme is involved in the Krebs Cycle (also known as the Tricarboxylic Acid Cycle [TCA] or the Citric Acid ... These include benign mesenchymal tumors of the uterus, leiomyomatosis and renal cell carcinoma, and fumarase deficiency. ... and is also important in renal cell carcinoma. Mutations in this gene have been associated with the development of leiomyomas ... then leiomyomatosis and renal cell carcinoma/Reed's syndrome (multiple cutaneous and uterine leiomyomatosis) could result. ...
This is referred to as carcinocythemia or carcinoma cell leukemia and is associated with a poor prognosis. To date, a variety ... Krebs, Matthew G; Antonello, Jenny; Ayub, Mahmood; Faulkner, Suzanne; Priest, Lynsey; Carter, Louise; Tate, Catriona; Miller, ... 2004). "Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with non- ... CTCs that originate from carcinomas (cancers of epithelial origin, which are the most prevalent) can be classified according to ...
Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y (April 2002). "Association and regulation of casein kinase 2 activity by adenomatous ... "Expression and interaction of different catenins in colorectal carcinoma cells". International Journal of Molecular Medicine. 8 ... 3.0.CO;2-9. PMID 10805953. van Es JH, Giles RH, Clevers HC (March 2001). "The many faces of the tumor suppressor gene APC". ... 327 (2): 359-67. doi:10.1016/S0022-2836(03)00144-X. PMID 12628243. Davies G, Jiang WG, Mason MD (April 2001). "The interaction ...
Increased nuclear β-catenin levels have also been noted in basal cell carcinoma (BCC), head and neck squamous cell carcinoma ( ... Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y (April 2002). "Association and regulation of casein kinase 2 activity by adenomatous ... Ren J, Li Y, Kufe D (May 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin ... Yamamoto M, Bharti A, Li Y, Kufe D (May 1997). "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta- ...
... adrenal carcinomas and lymphomas. There is recent and growing interest in fibrolamellar hepatocellular carcinoma. The molecular ... Fischer and Krebs won the Nobel Prize in Physiology or Medicine in 1992 for this discovery and their continued work on kinases ... Fischer EH, Krebs EG (Sep 1955). "Conversion of phosphorylase b to phosphorylase a in muscle extracts". The Journal of ... Edmond H. Fischer and Edwin G. Krebs at the University of Washington discovered PKA in the late 1950s while working through the ...
... carcinoma, krebs 2 MeSH C04.557.470.200.260 - carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... carcinoma, bronchogenic MeSH C04.588.894.797.520.230 - carcinoma, non-small-cell lung MeSH C04.588.894.797.520.235 - carcinoma ... carcinoma, medullary MeSH C04.557.465.625.650.240.325 - carcinoma, merkel cell MeSH C04.557.465.625.650.240.390 - carcinoma, ...
O incremento dos niveis de β-catenina nuclear tamén se detectou no carcinoma de células basais,[58] carcinoma de células ... Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y (Apr 2002). "Association and regulation of casein kinase 2 activity by adenomatous ... Ren J, Li Y, Kufe D (May 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin ... Yamamoto M, Bharti A, Li Y, Kufe D (May 1997). "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta- ...
... esophageal carcinoma, lung cancer, hepatocellular carcinoma, and neuroblastoma. HLA-F has also been associated with ... "Entrez Gene: HLA-F major histocompatibility complex, class I, F". Krebs J, Goldstein E, Kilpatrick S (2014). "Chapter 18: ... and carcinoma. HLA-F is expressed on the cell surface of activated lymphocytes, HeLa cells, EBV-transformed lymphoblastoid ... "Lesion human leukocyte antigen-F expression is associated with a poor prognosis in patients with hepatocellular carcinoma". ...
Zihlmann KB, Ducray AD, Schaller B, Huber AW, Krebs SH, Andres RH, et al. (December 2005). "The GDNF family members neurturin, ... May 2009). "Artemin is oncogenic for human mammary carcinoma cells". Oncogene. 28 (19): 2034-45. doi:10.1038/onc.2009.66. PMID ... March 2010). "Artemin stimulates oncogenicity and invasiveness of human endometrial carcinoma cells". Endocrinology. 151 (3): ... Artemin and GFRalpha3 expressions and their relevance to perineural invasiveness and metastasis of pancreatic carcinoma]". Nan ...
Krebs AD, Averbuch SD, Ochs JS, Grous J, Fandi A, Johnson DH (March 2004). "Gefitinib in combination with paclitaxel and ... of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma ... of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma ... INTACT 2" "Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in ...
Lewin, Benjamin; Krebs, Jocelyn E.; Kilpatrick, Stephen T.; Goldstein, Elliott S., eds. (2011). Lewin's genes X (10th ed.). ... "Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular ... 6 (2): 149-152. doi:10.4161/rna.6.2.8046. PMID 19229134. Cenik C, Chua HN, Zhang H, Tarnawsky SP, Akef A, Derti A, Tasan M, ... 2 (1): 135-140. CiteSeerX doi:10.1016/S1097-2765(00)80122-7. PMID 9702200. López-Lastra M, Rivas A, Barría MI ...
Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Gröne ... "DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer". Biochem. Soc. Trans. 33 (Pt 4 ... Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF, Poustka A (1999). "The genomic ... J. 366 (Pt 2): 511-20. doi:10.1042/BJ20011876. PMC 1222789. PMID 12015815. Bikker FJ, Ligtenberg AJ, Nazmi K, Veerman EC, van't ...
Krebs, Albin (December 2, 1975). "Anna Roosevelt Halsted, President's Daughter, Dies - White House Assistant Went With Father ... "Association of Streptococcus bovis with carcinoma of the colon". New England Journal of Medicine. 297 (15): 800-802. doi: ...
Krebs R, Jeltsch M (Dec 2013). "Die lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in ... "Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas". ... Krebs R, Jeltsch M (June 2013). "The lymphangiogenic growth factors VEGF-C and VEGF-D. Part 1: Basic principles and embryonic ... 15 (2): 290-98. doi:10.1002/j.1460-2075.1996.tb00359.x. PMC 449944. PMID 8617204. Joukov V, Pajusola K, Kaipainen A, Chilov D, ...
1971). "Prospects for Cryo-Immunotherapy in Cases of Metastasizing Carcinoma of the Prostate". Cryobiology. 8 (3): 271-79. doi: ... Ohio by Mark Krebs, MD, FACC, Matthew Hoskins, RN, BSN and Ken Peterman, RN, BSN. These electrophysiology experts were ... Cryoablation has similar outcomes to radiofrequency ablation when treating renal cell carcinoma. Cryoablation for breast cancer ... carcinomas and epitheliomas. De Quervain successfully used of carbonic snow to treat bladder papillomas and bladder cancers in ...
Boulter CA, Wagner EF (March 1988). "The effects of v-src expression on the differentiation of embryonal carcinoma cells". ... Raisky O, Nykänen AI, Krebs R, et al. (April 2007). "VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and ... March 2006). "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma". Carcinogenesis. 27 ... Przyborski SA (2001). "Isolation of human embryonal carcinoma stem cells by immunomagnetic sorting". Stem Cells. 19 (6): 500-4 ...
Krebs I, Weis I, Hudler M, Rommens JM, Roth H, Scherer SW, Tsui LC, Füchtbauer EM, Grzeschik KH, Tsuji K, Kunz J (Jul 1997). " ... Zhao XL, Sun T, Che N, Sun D, Zhao N, Dong XY, Gu Q, Yao Z, Sun BC (Mar 2011). "Promotion of hepatocellular carcinoma ... Over-expression of Twist or methylation of its promoter is common in metastatic carcinomas. Hence targeting Twist has a great ... 3.0.CO;2-0. PMID 10572240. Kress W, Schropp C, Lieb G, Petersen B, Büsse-Ratzka M, Kunz J, Reinhart E, Schäfer WD, Sold J, ...
Krebs HA, Johnson WA (April 1937). "Metabolism of ketonic acids in animal tissues". The Biochemical Journal. 31 (4): 645-60. ... The citric acid cycle (CAC) - also known as the TCA cycle (tricarboxylic acid cycle) or the Krebs cycle - is a series of ... The citric acid cycle itself was finally identified in 1937 by Hans Adolf Krebs and William Arthur Johnson while at the ... Meléndez-Hevia E, Waddell TG, Cascante M (September 1996). "The puzzle of the Krebs citric acid cycle: assembling the pieces of ...
Heme increases the mitochondrial activity thereby helping in activation of respiratory system Krebs Cycle and Electron ... Qumseya, BJ; David, W; Wolfsen, HC (January 2013). "Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma". ... 45 (1-2): 71-73. doi:10.1515/znc-1990-1-212. S2CID 42965243. "Aminolevulinic acid". Drug Information Portal. U.S. National ... The enzymes involved in this pathway are glutamyl-tRNA synthetase, glutamyl-tRNA reductase, and glutamate-1-semialdehyde 2,1- ...
Krebs, John R. (June 2005). "The Croonian Lecture 2004 Risk: food, fact and fantasy". Philosophical Transactions of the Royal ... Lazarus-Barlow, W. S. (1909). "The Croonian Lectures on Radioactivity and Carcinoma: An Experimental Inquiry: Delivered before ... Radioactivity and Carcinoma 1908 Archibald Garrod, Inborn Errors of Metabolism 1907 William John Simpson, On Plague 1906 ... Adventures in vascular biology 2004 John Krebs, Risk, food, fact and fantasy 2003 Tim Hunt, Cell growth, cell division and the ...
Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. mir-210 ... "MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur ... 63 (2): 94-100. doi:10.1002/iub.427. PMC 4497508. PMID 21360638. Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, ... 7 (2): 265-267. doi:10.4161/cbt.7.2.5745. PMID 18347426. Camps C, Buffa FM, Colella S, Moore J, Sotiriou C, Sheldon H, Harris ...
Lewin, Benjamin., Krebs, Jocelyn E., Kilpatrick, Stephen T., Goldstein, Elliott S., Lewin, Benjamin. (10th ed.). Sudbury, Mass ... "Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular ... 2 (10): 17056. doi:10.1038/natrevmats.2017.56.. *^ a b Gousseinov, Elina; Kozlov, Mikhail; Scanlan, Claire; Hammons, Aaron; Bei ... 6 (2): 149-52. doi:10.4161/rna.6.2.8046.. *^ Cenik, Can; Chua, Hon Nian; Zhang, Hui; Tarnawsky, Stefan P.; Akef, Abdalla; Derti ...
In 1956 Edwin Krebs and Edmond Fischer discovered that adenosine triphosphate (ATP) is required for the conversion of glycogen ... February 2013). "Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate ... has been linked to human prostate carcinoma. Inhibition of sAC, or knockdown by RNA interference (RNAi) transfection has been ... 43 (3 Pt 2): 769-76. doi:10.1016/0092-8674(85)90250-8. PMID 3907860. Desch M, Schinner E, Kees F, Hofmann F, Seifert R, ...
LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool. Cluster of differentiation GRCh38: ... Schiemann WP, Graves LM, Baumann H, Morella KK, Gearing DP, Nielsen MD, Krebs EG, Nathanson NM (June 1995). "Phosphorylation of ... 162 (1-2): 145-9. doi:10.1016/S0303-7207(00)00200-8. PMID 10854707. S2CID 24089439. Blanchard F, Duplomb L, Wang Y, Robledo O, ... regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through ...
In 1954, Hans Adolf Krebs succeeded Sir Rudolph Peters as Professor and Head of the Department of Biochemistry, to which the ... with the latter leading to leukaemia and the latter to carcinoma of the bronchus and to the predominance of carcinoma of the ... 2], and Cicely Williams. Much of his time was occupied in trying to raise funds, but the operation of the institute in the ...
Because succinic acid can not be made from succinyl coa, treatment is with oral succinic acid, which allows the krebs cycle, ... "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. 83 (4): 456 ... 36 (2): 281-95. doi:10.1016/S1357-2725(03)00246-2. PMID 14643893. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, ... 10 (2): 186-98. doi:10.1007/s13311-013-0177-6. PMC 3625391. PMID 23385875. Parikh S, Saneto R, Falk MJ, Anselm I, Cohen BH, ...
Allais-Bonnet A, Grohs C, Medugorac I, Krebs S, Djari A, Graf A, Fritz S, Seichter D, Baur A, Russ I, Bouet S, Rothammer S, ... melanoma and non-small cell lung carcinoma cell lines. It also has been shown that up-regulation of OLIG2 together with LMO1 ... 11 (2): 196-202. doi:10.1038/sj.cdd.4401332. PMID 14576772. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN ... 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736. Lin YW, Deveney R, Barbara M, Iscove NN, Nimer SD, ...
Krebs, Robert E. (1998). "Platinum". The History and Use of our Earth's Chemical Elements. Greenwood Press. pp. 124-127. ISBN ... Platinum drugs are used to treat a wide variety of cancers, including testicular and ovarian carcinomas, melanoma, small-cell ... The spin of 1/2 and other favourable magnetic properties of the nucleus are utilised in 195Pt NMR. Due to its spin and large ... ISBN 978-92-2-109816-4. Archived from the original on 24 March 2017. Murata, K. J. (1958). in Symposium on Spectrocemical ...
"Löst Glyphosat Krebs aus? (announcement 007/2015)" (PDF) (in German). German Institute for Risk Assessment. March 23, 2015.. ... These include the induction of positive trends in the incidence of renal tubule carcinoma and haemangiosarcoma in male mice, ... Cl2P(=O)-CH2Cl + 2 H2O → (HO)2P(=O)-CH2Cl + 2 HCl. (HO)2P(=O)-CH2Cl + H2N-CH2-COOH → (HO)2P(=O)-CH2-NH-CH2-COOH + HCl. The main ... Archived from the original on April 2, 2013.. *^ a b "Resisting Roundup". The New York Times. May 16, 2010. Retrieved March 24, ...
Johann Heinrich Jänisch: Abhandlung von dem Krebs und von der besten Heilart desselben. 2. Ausg. St. Petersburg 1785 ( ... Displazija - Carcinoma in situ - Invazivni rak - Metastaze. Topografija. Anus - Mokraćni mjehur - Krv - Žučni kanal - Kost - ... Krebs in Deutschland, Häufigkeiten und Trends. (PDF; 2,4 MB) 4. Auflage 2004, herausgegeben von der Arbeitsgemeinschaft ... Deutsche Ausgabe: Der König aller Krankheiten: Krebs - eine Biografie, DuMont Buchverlag, Köln 2012, ISBN 978-3-8321-9644-8. ...
Edwin G. Krebs. அமெரிக்க ஐக்கிய நாடு. 1993. Sir Richard J. Roberts. ஐக்கிய இராச்சியம். "for their discoveries of split genes"[ ... "for his discovery of the Spiroptera carcinoma"[20]. 1927. Julius Wagner-Jauregg. ஆஸ்திரியா. "for his discovery of the ... Sir Hans Adolf Krebs. ஐக்கிய இராச்சியம். "for his discovery of the சிட்ரிக் அமில சுழற்சி"[44]. ...
"for his discovery of the Spiroptera carcinoma" [27]. 1927 Julius Wagner-Jauregg Austria "for his discovery of the therapeutic ... Sir Hans Adolf Krebs United Kingdom "for his discovery of the citric acid cycle" [51]. ... Archived from the original on 2 February 2007. Retrieved 21 November 2008.. ... 2][3] While commonly referred to as the Nobel Prize in Medicine, Nobel specifically stated that the prize be awarded for " ...
Edwin G. Krebs. Amerika Serikat. 1993. Sir Richard J. Roberts. Britania Raya. penemuan bahwa gen di eukariota bukan merupakan ... penerangan Spiroptera carcinoma dan kanker yang dipengaruhi secara buatan pada hewan [29]. ... Sir Hans Adolf Krebs. Britania Raya. penemuan siklus asam sitrat pada pernapasan seluler[52]. ... 2][3] Meskipun umumnya disebut sebagai Nobel Kedokteran, Nobel secara spesifik menyatakan bahwa penghargaan tersebut ...
գերմ.՝ Hans Adolf Krebs) Կիտրոնաթթվի փուլերի բացահայտման համար։ Բնօրինակ տեքստ (անգլ.) for his discovery of the citric acid ... for his discovery of the Spiroptera carcinoma [27]. 1927 Յուլիուս Վագներ-Յաուրեգ. (գերմ.՝ Julius Wagner Ritter von Jauregg) ... 2,0 2,1 «The Nobel Prize in Physiology or Medicine 1901» (անգլերեն)։ Նոբելյան ֆոնդ։ Արխիվացված է օրիգինալից 2012-10-15-ին։ ... 35,0 35,1 35,2 «The Nobel Prize in Physiology or Medicine 1934» (անգլերեն)։ Նոբելյան ֆոնդ։ Արխիվացված է օրիգինալից 2012-10-15- ...
Lüscher B, Kuenzel EA, Krebs EG, Eisenman RN (April 1989). "Myc oncoproteins are phosphorylated by casein kinase II". The EMBO ... Malfunctions in Myc have also been found in carcinoma of the cervix, colon, breast, lung and stomach.[5] Myc is thus viewed as ... 57 (2-3): 109-11. PMID 1914517. doi:10.1159/000133124.. *. Blackwood EM, Eisenman RN (March 1991). "Max: a helix-loop-helix ... 2 (10): 764-76. PMID 12360279. doi:10.1038/nrc904.. *. Nilsson JA, Cleveland JL (December 2003). "Myc pathways provoking cell ...
High fructose consumption can lead to excess pyruvate production, causing a buildup of Krebs cycle intermediates. Accumulated ... Medina Villaamil (2011-02-01). "Fructose transporter Glut5 expression in clear renal cell carcinoma". Oncology Reports. 25 (2 ... 101 (2): 360-367. doi:10.1016/0016-5085(91)90012-a. PMID 2065911. Ushijima, K; Fujisawa T; Riby J; Kretchmer N (1991). " ... 360 (Pt 2): 265-276. doi:10.1042/0264-6021:3600265. PMC 1222226. PMID 11716754. Beyer, PL; Caviar EM; McCallum RW (2005). " ...
"Löst Glyphosat Krebs aus? (announcement 007/2015)" (PDF) (in German). German Institute for Risk Assessment. March 23, 2015. ... These include the induction of positive trends in the incidence of renal tubule carcinoma and haemangiosarcoma in male mice, ... Use of 2-4 D and other herbicides like glyphosate to clear milkweed along roads and fields may have contributed to a decline in ... PCl3 + H2CO → Cl2P(=O)−CH2Cl Cl2P(=O)−CH2Cl + 2 H2O → (HO)2P(=O)−CH2Cl + 2 HCl (HO)2P(=O)−CH2Cl + H2N−CH2−COOH → (HO)2P(=O)−CH2 ...
Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, et al. (February 2014). "Transcriptome-based network analysis ... February 2017). "Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ ... 4: 2. doi:10.1186/s40169-015-0047-4. PMC 4384891. PMID 25852818. Lissner D, Schumann M, Batra A, Kredel LI, Kühl AA, Erben U, ... 66 (2): 605-12. doi:10.1158/0008-5472.CAN-05-4005. PMID 16423985. Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, ...
DF Gudbjartsson et al., "ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma," Nature ... and the Hans Krebs Medal. His work has been recognized by patient and research organizations such as the American Alzheimer's ... "New basal cell carcinoma susceptibility loci," Nature Communications volume 6, Article number 6825, 9 April 2015. J Gudmundsson ... "Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation ...
"Fiebertherapie bei Krebs vernachlässigt" (PDF). Ärztl. Praxis. 86: 3377. McCarthy, EF (2006). "The Toxins of William B. Coley ... by exposing the tumor to infection including the report of French physician Dussosoy who covered an ulcerated breast carcinoma ... Hobohm, U.: [2] Archived 2009-12-11 at the Wayback Machine Fever and cancer in perspective, Cancer Immunol Immunother 2001) 50 ... 2 (1): 43-9. doi:10.4103/0976-9668.82318. PMC 3312698. PMID 22470233. Kienle GS (2012). "Fever in Cancer Treatment: Coley's ...
Das Krankheitsbild des Typ-2-Diabetes scheint ber sehr distinkte Mechanismen und Signalwege mit dem Tumorgeschehen verkn pft zu ... El-Serag HB, Hampel H, Javadi F: The association between diabetes and hepatocellular carcinoma: a systematic review of ... Diabetes und Krebs: Eine Bestandsaufnahme. Dtsch Arztebl 2016; 113(17): [18]; DOI: 10.3238/PersDia.2016.04.29.05 ... Institut f r Diabetes und Krebs (IDC), Helmholtz Zentrum M nchen, Joint Heidelberg-IDC Translational Diabetes Unit, Heidelberg ...
RNA has been found in extracts of ascites carcinoma Krebs-2 cells. This was done using UV-irradiation on extracts supplemented ... RNA has been found in extracts of ascites carcinoma Krebs-2 cells. This was done using UV-irradiation on extracts supplemented ...
Krebs EG. (1990) Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 ... Therapeutic effects of CP-358,774 p.o. on human A431 carcinoma xenografts in athymic mice. Human vulvar A431 carcinoma cells ... such as non-small cell lung carcinoma and brain, bladder, breast, and ovarian carcinomas (Gullick, 1991). EGF at picomolar ... Inhibition of HN5 carcinoma xenograft growth by CP-358,774. In the experiment described in Fig. 4, tumor sizes for CP-358,774- ...
... being explored in an effort to develop more effective and selective treatment of patients with advanced colorectal carcinoma. ... H.A. Krebs, R. Hems, B. Tyler. The regulation of folate and methionine metabolism. Biochem. J. 158: 341 (1976).PubMedGoogle ... H.S. Krebs, R. Hems, B. Tyler. The regulation of folate and methionine metabolism. Biochem. J. 158: 341 (1976).PubMedGoogle ... A phase II trial of continuous infusion 5-FU and weekly low dose cisplatin in colorectal carcinoma. Proc. Am. Soc. Clin. Oncol ...
Krebs ET Jr, Krebs ET Sr, Beard HH: The unitarian or trophoblastic thesis of cancer. Med Rec 163 (7): 149-74, 1950. ... mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. Not effective ... The term vitamin B-17 was given to laetrile by E.T. Krebs Jr, but it is not an approved designation by the Committee on ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ...
Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with an increasing incidence. The understanding of the molecular ... Krebs ,Medizin, (1). *MHC class I chain-related protein (1). *Molecular imaging (1) ... Activation of the PI3K/AKT Pathway in Merkel Cell Carcinoma (2012) Hafner, Christian ; Houben, Roland ; Baeurle, Anne ; Ritter ... Background Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor ...
Krebs. Isolation and characterization of human cDNA clones encoding the alpha and the alpha subunits of casein kinase II. ... CK2alpha/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of ... Protein kinase CK2alpha subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative ... The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta- ...
Krebs explained it to me was the cryo (freezing) only destroys .5mm of live kidney tissue outside of the tumor. With only the ... The type of cancer is multifocal chromophobe renal cell carcinoma. My first post op cat scan was clear, the second 3 months ... Krebs ( my Interventual Radiologist) froze a 2.7cm. tumor. June 29th follow-up visit at St. Josephs Hospital was with mixed ... Lucky me 2. I had bilateral RCC at Dx. Both open partials. Lost 30% of left, 5.5cm stage 3b grade 3 and 20% of right, 2.5cm ...
Krebs K, B ttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, J ger C, Schmitt E, Bohne F, Aichler M, Uckert W, ... Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.. J Clin Invest. 2015 Oct ... Infektion, Entz ndung und Krebs * Tumorvirologie * Prof. Jean Rommelaere *Publikationen Prof. Rommelaere ... Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development.. Cancer Cell. 2016 Aug 8;30(2 ...
Thatcher N, Blackledge G, Crowther D. Advanced recurrent squamous cell carcinoma of the head and neck. Results of a ... Kurbacher CM, Wagner U, Kolster B, Andreotti PE, Krebs D, Bruckner HW. Ascorbic acid (vitamin C) improves the antineoplastic ... Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer. Feb 1 1999;85(3):640-650.. 9. ... A phase II study of combination chemotherapy in advanced ovarian carcinoma with cisplatin and cyclophosphamide plus reduced ...
... to the Krebs cycle vs. ii) active segment of the Krebs cycle with aconitase and isocitrate dehydrogenase-3 (ACO-IDH3), which is ... to the Krebs cycle vs. ii) active segment of the Krebs cycle with aconitase and isocitrate dehydrogenase-3 (ACO-IDH3), which is ... Human hepatocellular carcinoma HepG2 cells are forced to oxidative phosphorylation (OXPHOS), when cultured in aglycemic ... Human hepatocellular carcinoma HepG2 cells are forced to oxidative phosphorylation (OXPHOS), when cultured in aglycemic ...
HLRCC is characterized by germ-line mutation of the Krebs cycle enzyme, FH (33 , 34) . A shows an abdominal image of a young ... The VHL gene is the gene for the inherited form of clear cell renal carcinoma associated with VHL and for common form of ... type 1 papillary renal carcinoma (21) . (A) CT of abdomen reveals multiple bilateral solid renal tumors. (B) Representative ... BHD associated renal tumors may be chromophobe renal carcinoma (upper right), hybrid-oncocytic neoplasms (center right) or ...
The effects of twelve monosaccharides on the oxygen uptake of Krebs-2 ascites carcinoma cells were determined during prolonged ... Of these inhibiting sugars, the nonglycolyzable were 2-deoxyglucose, glucosone, and mannoheptulose; and the glycolyzable were ... controlled the degree of inhibition and its time of onset when added to tumor cells in combination with 2-deoxyglucose or with ...
Carcinoma-Associated Mucin; Krebs Von Den Lungen-6; Peanut-Reactive Urinary Mucin; Polymorphic Epithelial Mucin; Tumor- ... intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This. gene is ... Mucin 1, Cell Surface Associated; PUM; PEM; CD227; Mucin 1, Transmembrane; Breast Carcinoma-Associated Antigen DF3; Cancer ... CPTC-MUC1-2 peptide ELISA. Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note ...
Wasmer MH, Krebs P. The Role of IL-33-dependent Inflammation in the tumor microenvironment. Front Immunol. 2016;7:682.PubMed ... Detection of interleukin-33 in serum and carcinoma tissue from patients with hepatocellular carcinoma and its clinical ... ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma. Eur J Immunol. 2011;41(7):1902-12.PubMed ... Interleukin-32 expression and Treg infiltration in esophageal squamous cell carcinoma. Anticancer Res. 2015;35(5):2941-7.PubMed ...
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH ... Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst. 2008 Sep 3;100(17):1260-2. doi: 10.1093/jnci/ ... Within mitochondria, the SDH enzyme links two important pathways in energy conversion: the citric acid cycle (or Krebs cycle) ... or renal cell carcinoma, which is a type of kidney cancer. SDHB gene mutations have been identified in people a condition ...
Das letztere wird von den Pathologen in der Regel nicht mehr als echtes Carcinoma... ... Das ductale und das lobuläre Carcinoma in situ. ... Beim Carcinoma in situ der Brust unterscheiden wir 2 Formen: ... Maass H., Eidtmann H., Schreer I. (1993) Behandlung des Carcinoma in situ. In: Krebs D., Berg D. (eds) Gynäkologie und ... Ten-year results of breast-conserving surgery and definitive irradiation for intraductal carcinoma (ductal Carcinoma in situ) ...
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH ... Renal cell carcinoma 2005: new frontiers in staging, prognostication and targeted molecular therapy. J Urol 2005;173:1853-62. ... Human renal carcinoma: characterization of five new cell lines. J Surg Oncol 1985;28:237-44. ... Renal cell carcinomas (RCC) are a heterogeneous group of tumors with a wide range of aggressiveness. Noninvasive methods to ...
... carcinoma (e.g., Walker, basal cell, basosquamous, Brown-Pearce, ductal, Ehrlich tumor, in situ, Krebs 2, Merkel cell, mucinous ... ovarian carcinoma, rhabdomyosarcoma, sarcoma (e.g., Ewing, experimental, Kaposi, and mast cell), neoplasms (e.g., bone, breast ... 2 are 20 μm.. The effects of double-stranded RNA corresponding to mex-3 on levels of the endogenous mRNA was shown by in situ ... 2C).. In contrast, the progeny of animals injected with ds-gfpG RNA are affected (FIGS. 2D-F). Observable GFP fluorescence is ...
Grading Karzinom Krebs Oncology Onkologie Staging TNM TNM staging system Tumor Classifiction Tumorklassifikation carcinoma ... These are specified only for carcinoma of the breast; for other sites, reference must be made back to the general rules. which ... 2.Early Detection Branch, Division of Cancer Prevention and ControlNational Cancer InstituteBethesdaUSA ...
... carcinoma (e.g., Walker, basal cell, basosquamous, Brown-Pearce, ductal, Ehrlich tumor, in situ, Krebs 2, merkel cell, mucinous ... 10 is a copy of an autoradiogram showing TRF lengths of ovarian carcinoma and control normal cells. DNA from cells in ascitic ... Characteristics of Ovarian Carcinoma Tumor Cells from Ascitic Fluid Mean TRF Telomerase Patient Description Length (kbp) ... Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. USA 91:2900-2904 (1994). Strahl and ...
ketoglutarate in the Krebs cycle and are thought to be involved in the prevention of oxidative damage within the cell [52, 59, ... 60]. IDH mutations, first identified in colorectal carcinoma and frequently found in brain tumors, arise in approximately 15-30 ... Furthermore, study of mutations occurring in epigenetic modifying genes has identified potential biomarkers, such as 2-HG in ... 2, no. 4, pp. 254-264, 2012. View at Google Scholar. *C. L. Green, C. M. Evans, L. Zhao et al., "The prognostic significance of ...
Carcinoma-associated mucin; CD227; DF3 antigen; EMA; Episialin; Epithelial Membrane Antigen; H23 antigen; H23AG; KL-6; Krebs ... Protein Aliases: Breast carcinoma-associated antigen DF3; CA 15-3; Cancer antigen 15-3; ... References (2). Have you cited this antibody in a publication? so we can reference it in this datasheet. ... Host server : magellan-tomcat-2-prod:8080/ ...
STEAM TRADING CARDS SYSTEM SHOCK 2 Financial treasury and forex management cs syllabus #### Forex forum sri lanka ... 639 seeded gallbladder carcinoma, 204 seeded gastric carcinoma, 201, 204, 206 seeded ovarian carcinoma, 201203, 205 seeded ... Most com- monly, however, this cyclic pathway is called the Krebs cycle, after its principal discoverer, Sir Hans Krebs. Green ... See also bowel abnormal radiologic observations, 644, 646, 650652, 654, 659, 661 biphasic enteroclysis, 643 breast carcinoma ...
HLRCC is characterized by a predisposition to leiomyomas of the skin and the uterus as well as renal cell carcinoma. The ... It is involved in generating energy through a metabolic pathway of the Krebs cycle in the mitochondria, but the role of FH in ... HLRCC is characterized by a predisposition to leiomyomas of the skin and the uterus as well as renal cell carcinoma. The ... On the resulting heat map (Figure 4), patients who had familial renal carcinoma were discriminated from controls. Principle ...
Lymphoprep/Krebs HEPES Ring solution 3:1, and Lymphoprep/Krebs HEPES Ring solution 1:2. Cells were centrifuged at 1,500 × g for ... Ovarian carcinoma cells with low levels of β-F1-ATPase are sensitive to combined platinum and 2-deoxy-d-glucose treatment. Emma ... Two ovarian carcinoma cell lines (CaOv-4 and SKOV-3) were cultured in 96-well plates in the presence or absence of the glucose ... Ovarian carcinoma cells with low levels of β-F1-ATPase are sensitive to combined platinum and 2-deoxy-d-glucose treatment ...
Hereditary Papillary Renal Carcinoma. Introduction. Hereditary papillary renal carcinoma (HPRC) (OMIM) is an autosomal dominant ... Interruption of the Krebs cycle because of reduced or absent fumarate hydratase activity results in increased levels of ... Zbar B, Glenn G, Merino M, et al.: Familial renal carcinoma: clinical evaluation, clinical subtypes and risk of renal carcinoma ... Analysis of renal carcinomas up to the year 2000 in the Sweden Family-Cancer Database, which includes all Swedes born since ...
The truncated Krebs cycle and other metabolic ramifications of mitochondrial membrane cholesterol". The Journal of Biological ... lymphocyte reactivity and death in patients with bronchial carcinoma". Journal of Cancer Research and Clinical Oncology. 115 (6 ... citric acid cycle, malate-aspartate shuttle Krebs, HA; Bellamy D (1960). "The interconversion of glutamic acid and aspartic ... "Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma". Cancer Research. 52 (5 ...
Khoja L, Backen A, Sloane R, Menasce L, Ryder D, Krebs M, Board R, Clack G, Hughes A, Blackhall F, Valle JW, Dive C. ... Circulating biomarkers in hepatocellular carcinoma. Morris KL, Tugwood JD, Khoja L, Lancashire M, Sloane R, Burt D, Shenjere P ... Cummings J, Morris K, Zhou C, Sloane R, Lancashire M, Morris D, Bramley S, Krebs M, Khoja L, Dive C. ... my doctoral studies into the prevalence and biomarker utility of circulating tumour cells in melanoma and pancreatic carcinomas ...
  • BHD associated renal tumors may be chromophobe renal carcinoma ( upper right ), hybrid-oncocytic neoplasms ( center right ) or oncocytoma ( lower right ). (
  • Mutations in the SDHB gene have been found in a small number of people with gastrointestinal stromal tumors (GISTs), which are a type of tumor that occurs in the gastrointestinal tract, or renal cell carcinoma, which is a type of kidney cancer. (
  • Renal cell carcinomas (RCC) are a heterogeneous group of tumors with a wide range of aggressiveness. (
  • The incidence of renal tumors, both malignant renal cell carcinomas (RCC) and benign renal tumors, has increased significantly in the last 20 years ( 1 ). (
  • In the case of renal tumors, biopsies are not routinely done, due to the risk of hemorrhage and high likelihood of indeterminate histology ( 2, 3 ). (
  • Fluorocholine transport mediated by the organic cation transporter 2 (OCT2,SLC22A2): implication for imaging of kidney tumors. (
  • It shows that ccRCC can be subdivided according to HIF-2, into HIF-2-dependent and -independent tumors. (
  • Carcinomas of the vagina are uncommon tumors comprising about 2% of the cancers that arise in the female genital system. (
  • 2 ] Therefore, tumors that may have actually originated in the apical vagina but extend to the cervix are classified as cervical cancers. (
  • PFT was administered orally (2 g/kg/day) to mice 6 days/week, either 2 days before tumor cell inoculation or 9 days after inoculation to mice bearing solid tumors. (
  • Tumors were mostly grade 2, ER positive and Her2 negative. (
  • Lamas et al reported on 2 cases of large mixed adrenal tumors that had a heterogeneous appearance and areas of fat density on imaging and resulted in autonomous cortisol production leading to Cushing syndrome. (
  • All 3 lesions contained myelolipomatous foci throughout the neoplasm, and 2 of the tumors contained several pure lipomatous foci. (
  • Among these different HKs, HK-2 is found to be expressed of high rate in malignant tumors and plays a key role in the development of Warburg phenotype. (
  • Effect of endotoxin on liver carbohydrate of mice bearing transplant- able tumors sarcoma 37 and krebs-2 carcinoma. (
  • Renal cell carcinomas are typically solitary and aggressive tumors displaying papillary type 2 or collecting duct histology. (
  • When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation. (
  • Human hepatocellular carcinoma HepG2 cells are forced to oxidative phosphorylation (OXPHOS), when cultured in aglycemic conditions at galactose and glutamine. (
  • Validation of VX2 as a Hepatocellular Carcinoma Model: Comparison of the Molecular Reaction of VX2 and HepG2 Tumor Cells to Sorafenib In Vitro. (
  • As there is currently no superior hepatocellular carcinoma (HCC) model with percutaneous vascular access for transarterial treatments available, the VX2 rabbit model is frequently used for in vivo investigations on liver carcinoma. (
  • Hepatocellular carcinoma (HCC) is the third most common cause of cancer related mortality world-wide and therapeutic options are very limited. (
  • In the present study, we investigated the antitumor activity of chrysin against hepatocellular carcinoma (HCC) and the role of HK-2 played for chrysin to exert its function. (
  • Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma. (
  • Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. (
  • by Kouichi Kitamura, Lusheng Que, Miyuki Shimadu, Miki Koura, Yuuki Ishihara, Kousho Wakae, Takashi Nakamura, Koichi Watashi, Takaji Wakita, Masamichi Muramatsu Hepatitis B virus (HBV) is one of the major etiological pathogens for liver cirrhosis and hepatocellular carcinoma. (
  • The VHL gene is the gene for the inherited form of clear cell renal carcinoma associated with VHL and for common form of sporadic, noninherited clear cell renal carcinoma. (
  • Ductal carcinoma of the head of the pancreas represents a considerable problem in oncology with a mortality rate of 8-12/100,000 and per year. (
  • Ductal carcinoma in situ (DCIS) is a heterogeneous group of lesions, and their classification and treatment is currently the subject of intense discussion. (
  • In patients with mixed histology, co-existed histology was invasive ductal carcinoma in 9 patients and invasive lobular carcinoma in 6 patients. (
  • Invazive ductal carcinoma is the most common accompanying subtype. (
  • Lisovsky M, Dresser K, Woda B, Mino-Kenudson M. Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. (
  • Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. (
  • Telomerase activity in human ovarian carcinoma," Proc. (
  • We have here examined chemopotentiating effects of glycolysis inhibitor 2-deoxy- d -glucose (DG) in two epithelial ovarian carcinoma (EOC) cell lines and 17 freshly isolated ascitic EOC cell samples, and we identify low expression of the β-F1-ATPase involved in mitochondrial ATP production as a candidate marker for sensitivity to this strategy. (
  • Whereas standard treatment (surgery and platinum-based combination chemotherapy) may be effective initially, the 5-year survival in epithelial ovarian carcinoma is only around 45% ( 1 ). (
  • This finding prompted us to first examine DG sensitivity and DG-mediated potentiation of cisplatin and carboplatin effects in two human ovarian carcinoma cell lines. (
  • Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (
  • Clinical biochemical pharmacology 5-formyltetrahydrofolate in combination with 5-fluorouracil in patients with advanced colorectal carcinoma: correlation with clinical response, In: Advances in Cancer Chemotherapy. (
  • 2 , 7 , 8 ] Laetrile has been used for cancer treatment both as a single agent and in combination with a metabolic therapy program that consists of a specialized diet, high-dose vitamin supplements, and pancreatic enzymes . (
  • Merkel cell carcinoma (MCC) is a highly aggressive skin cancer with an increasing incidence. (
  • CSNK2 phosphorylates various proteins that deal with cell cycle regulation, cell survival, cell morphology, cell metabolism, tumorigenesis, and cancer cell invasiveness [ 2 ] . (
  • The type of cancer is multifocal chromophobe renal cell carcinoma. (
  • We aimed to determine fractions of (i) glutaminolytic pathway involving aminotransferase reaction supplying 2-oxoglutarate (2OG) to the Krebs cycle vs. (ii) active segment of the Krebs cycle with aconitase and isocitrate dehydrogenase-3 (ACO-IDH3), which is typically inactive in cancer cells due to the citrate export from mitochondria. (
  • HLRCC is a hereditary cancer syndrome (56) in which affected individuals are at risk for the development of an aggressive form of type 2 papillary renal carcinoma. (
  • Hereditary leiomyomatosis and renal cell cancer (HLRCC, Online Mendelian Inheritance in Man accession number 605839) is a recently identified autosomal dominant tumor susceptibility syndrome characterized by a predisposition for the development of benign leiomyomas of the skin and the uterus (fibroids and myomas), as well as aggressive renal cell carcinoma with papillary type 2 or collecting duct histology [ 1 - 4 ]. (
  • Hereditary kidney cancer syndromes include von Hippel-Lindau disease, hereditary leiomyomatosis and renal cell cancer, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. (
  • During this time I was awarded an AstraZeneca Cancer Research UK Clinical Fellowship to begin my doctoral studies into the prevalence and biomarker utility of circulating tumour cells in melanoma and pancreatic carcinomas at different stages of disease. (
  • The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading. (
  • Pancreatic carcinoma is the fifth leading cause of cancer death in Germany. (
  • Overall survival and updated progression-free survival outcomes in a randomized phase 2 study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer. (
  • Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high grade serous ovarian and squamous non-small cell lung cancer. (
  • Andersen, Steven: 'Implantation metastasis after laparoscopic biopsy of bladder cancer' J Urol 153,3 Pt 2 1047-1048 3.1995 Tumorauslösung in der Bauchwand durch Biopsie von Blasenkrebs. (
  • Wertheimer, Savitz, Leeper: 'Childhood cancer in relation to indicators of magnet ic fields from ground current sources' Bioelectromagnetics 16,2 86-96 1995 stark erhöhtes Krebsrisiko durch Magnetfelder leitender Wasserrohre. (
  • The diagnostic and therapeutic implications of human chorionic gonadotropin-beta expression as a key to malignancy' Cancer 76,8 1299-1301 15.10.1995 hCG bei Krebs. (
  • Researchers think the drug SGI-110 may help treat people with GIST, pheochromocytoma and paraganglioma (PHEO/PGL), or kidney cancer related to hereditary leiomyomatosis and renal cell carcinoma (HLRCC). (
  • Zurück zum Zitat Allen NE, Tsilidis KK, Key TJ, Dossus L, Kaaks R, Lund E et al (2010) Menopausal hormone therapy and risk of endometrial carcinoma among postmenopausal women in the European Prospective Investigation Into Cancer and Nutrition. (
  • Cancer-Tutor: das Beck -Protokoll könnte die wirksamste alternative Krebs behandlung auf der Erde sein und das will etwas heißen, weil ich mehr als 600 alternative Krebsbehandlungen kenne. (
  • 1 ] Squamous cell carcinoma (SCC) accounts for approximately 80% to 90% of vaginal cancer cases and adenocarcinoma accounts for 5% to 10% of vaginal cancer cases. (
  • Expression of the included transporters and enzymes was in general well comparable between porcine and human intestinal tissue, although breast cancer resistance protein, monocarboxylate transporter 5, multidrug resistance protein (MRP) 1, MRP1, MRP3 (∼2-fold), and organic anion-transporting polypeptide (OATP) 4A1 (∼6-fold) was higher expressed in pig compared with human jejunum. (
  • We identified NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2) as the most highly expressed gene in renal cancer cells and evaluated its role in sustaining angiogenesis, chemoresistance, and mitochondrial dysfunction. (
  • We studied the effect of NM on human colon cancer cell line HCA-7 in vitro by measuring cancer cell proliferation, invasion, and expression of pro-inflammatory COX-2 and COX-1 proteins. (
  • 2 Improved screening methods have been linked to the recent decline in incidence and mortality of colorectal cancer. (
  • 3 In the current study, we investigated the antitumor potential of the nutrient mixture (NM) on human colon cancer cell line HCA-7 in vitro by measuring cell proliferation, Matrigel™ invasion, and the effect of NM on markers of inflammation: cyclooxygenase COX-1 and COX-2 protein expression. (
  • Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. (
  • Reviewed in [ 2 , 14 ] As a result, the use of laetrile as a cancer therapy or as a treatment for any other medical condition is not approved in the United States, but the compound continues to be manufactured and administered as an anticancer therapy, primarily in Mexico. (
  • Lac was significantly higher in cancer tissue than in muscle ( P = .01) and, in the nodes, showed a moderately negative correlation with median pO 2 ( r = −.76) over a range of approximately 0 to 30 mm Hg. (
  • Squamous cell carcinoma (SCC) is one of the most common kinds of cancer in cattle, humans and horses, affecting skin and other epithelial tissues (such as the surface of the eyeball). (
  • COX-2 is involved in tumor development and progression, and frequent overexpression of COX-2 in a variety of human cancers has made COX-2 an important drug target for cancer treatment. (
  • Non-invasive imaging of COX-2 expression in cancer would be useful for assessing COX-2-mediated effects on chemoprevention and radiosensitization using COX-2 inhibitors as an emerging class of anti-cancer drugs, especially for colorectal cancer. (
  • Herein, we describe the radiopharmacological analysis of [ 18 F]Pyricoxib, a novel radiolabeled COX-2 inhibitor, for specific PET imaging of COX-2 in colorectal cancer. (
  • Uptake of [ 18 F]Pyricoxib was assessed in human colorectal cancer cell lines HCA-7 (COX-2 positive) and HCT-116 (COX-2 negative). (
  • The novel PET radiotracer [ 18 F]Pyricoxib displays a promising radiopharmacological profile to study COX-2 expression in cancer in vivo. (
  • 2014): Insulin-like growth factor-i and risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition. (
  • youtuber - cancer // soft tissue carcinoma on leg. (
  • The effects of twelve monosaccharides on the oxygen uptake of Krebs-2 ascites carcinoma cells were determined during prolonged incubation. (
  • Changes in the level (A) and lifetime (B) of 4.5SH and 4.5SI RNAs in Krebs ascites carcinoma cells in response to heat shock. (
  • A shows an abdominal image of a young man affected with HLRCC with a large left-sided kidney mass that was found to by type 2 papillary RCC ( B ). (
  • and hereditary papillary renal carcinoma (HPRC, caused by pathogenic variants in MET). (
  • This is apparently the first reported case amoxicillin for sinus infection of papillary thyroid carcinoma arising in a TDR evaluated using 3DCT. (
  • 2014) MET is a potential target across all papillary renal cell carcinomas: result from a large molecular study of pRCC with CGH array and matching gene expression array. (
  • Phase II study of CC-486 (oral azacitidine) in previously treated patients with locally advanced or metastatic nasopharyngeal carcinoma. (
  • Thoracic metastases from nasopharyngeal carcinoma presenting as hypertrophic pulmonary osteoarthropathy: scintigraphic and CT findings. (
  • Small CTCs have been implicated in progressive disease and differentiation into small cell carcinomas, which often require a different therapeutic course. (
  • Beim Carcinoma in situ der Brust unterscheiden wir 2 Formen: Das ductale und das lobuläre Carcinoma in situ. (
  • Maass H., Eidtmann H., Schreer I. (1993) Behandlung des Carcinoma in situ. (
  • Beim duktalen Carcinoma in situ (DCIS) handelt es sich um eine heterogene Gruppe von Läsionen, deren Klassifikation und Therapie derzeit Gegenstand vieler Diskussionen ist. (
  • Carcinoma in Situ" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • Below are the most recent publications written about "Carcinoma in Situ" by people in Profiles. (
  • Tumeurs Du Tissu Conjonctif Et Des Tissus Mous 2 questions Neoplasms developing from some structure of the connective and subcutaneous tissue. (
  • Pathologically, 2 of the lesions were classified as adrenocortical neoplasms of uncertain malignant potential, and 1 lesion was classified as an adrenocortical adenoma. (
  • Inhibition of EGFr phosphotyrosine in an ex vivo assay format effectively estimates the potency and degree of inhibition of EGFr-dependent human LICR-LON-HN5 head and neck carcinoma tumor growth. (
  • Best Practice in Systemic Therapy for Head and Neck Squamous Cell Carcinoma. (
  • While mastectomy was the standard treatment up to only a few decades ago, as in the case of invasive carcinoma of the breast efforts are now made to save the breast. (
  • Adequate treatment of DCIS is also of decisive importance from the aspect of preventing invasive carcinoma of the breast. (
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (
  • The current standard of reference for measuring tumor oxygenation (pO 2 ) is the computerized Eppendorf oxygen electrode (18−20), which, unfortunately, is invasive and may not be suitable as a screening device. (
  • Roux-en Y open surgery or colonic interposition minimun invasive surgery such as laproscopy. (
  • The development of techniques for non-invasive monitoring of COX-2 functional expression would greatly facilitate efforts to understand the COX-2 pharmacology in a living organism. (
  • Esophageal cancers are histologically subdivided into two main histologic types: adenocarcinoma and esophageal squamous cell carcinoma (ESCC). (
  • CTCs that originate from carcinomas (cancers of epithelial origin, which are the most prevalent) can be classified according to the expression of epithelial markers, as well as their size and whether they are apoptotic. (
  • The common cancers are squamous cell carcinoma figure histologic and cytologic rcc variants may have normal renal development are provided free. (
  • Triple-negative breast cancers do not rely on the hormones estrogen and progesterone for growth, nor on human epidermal growth factor receptor 2 (HER2). (
  • The prevalence of signet ring features is between 2 to 4.5% of total breast cancers. (
  • Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. (
  • Patients with pancreatic carcinoma who are presented in surgical departments have tumours that are unresectable in 70-80% because of locally advanced disease or distant metastases. (
  • This scenario emphasizes that surgical therapy alone is not sufficient for pancreatic carcinoma and that prospective investigation of additional modalities is crucial. (
  • Pieces of solid tumor of human pancreatic carcinoma were subcutaneously transplanted in the backs of 28 nude mice which are 5-weeks old female. (
  • 13(2):95-97, Spring 2019. (
  • 13(2):98-102, Spring 2019. (
  • 13(2):103-107, Spring 2019. (
  • 13(2):108-110, Spring 2019. (
  • 13(2):111-114, Spring 2019. (
  • 13(2):115-117, Spring 2019. (
  • Sci Rep . 2019 Apr 2;9(1):5532. (
  • Using immunohistochemistry (IHC) and double immunofluorescence staining, we characterized the cellular and clinicopathological features of the IL-33/ST2 axis in different compartments in human esophageal squamous cell carcinoma (ESCC) surgical specimens. (
  • Li D, Peng W, Wu B, Liu H, Zhang R, Zhou R, Yao L, Ye L. Metallothionein Suppresses Carcinogenesis of Esophageal Carcinoma Cells through Inhibition of the Epithelial-Mesenchymal Transition and the Axis. (
  • 2013): Higher glycemic index and glycemic load diet is associated with increased risk of esophageal squamous cell carcinoma: a case-control study. (
  • Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma. (
  • Moreover, liver metastases of murine colon carcinoma show an up-regulation of FAS-L on tumor cell surface with a decreased expression of FAS from day 10 on. (
  • Ovarian metastases were found in 2 of 7 distant failures. (
  • Volume-localized Lac-edited MRS at 1.5 T was performed in vivo on the lymph node metastases of 14 patients whose conditions were untreated and who had primary occurrences of squamous cell carcinoma. (
  • A protein factor that specifically binds to the 5'-untranslated region of encephalomyocarditis virus (EMCV) RNA has been found in extracts of ascites carcinoma Krebs-2 cells. (
  • Addition of membrane-permeant dimethyl-2-oxoglutarate (dm2OG) to inhibited cells instantly partially restored respiration, evidencing the lack of 2OG-dehydrogenase substrate upon aminotransferase inhibition. (
  • Hypoxic O XPHOS cells increased 2-fold the NADPH oxidase activity, whereas hypoxic glycolytic cells decreased it. (
  • In contrast to aglycemic cells, glycolytic HepG2 cells decreased their respiration at hypoxia despite the dm2OG presence, i.e., even at unlimited respiratory substrate availability for 72 hr at 5% O 2 , exhibiting the canonical HIF-mediated adaptation. (
  • Glucosone, a slowly phosphorylated sugar of highest affinity to hexokinase, controlled the degree of inhibition and its time of onset when added to tumor cells in combination with 2-deoxyglucose or with each of the glycolyzable hexoses. (
  • Acute myeloid leukemia (AML) is a genetically heterogeneous disease characterized by malignant clonal proliferation of immature myeloid cells in the bone marrow, peripheral blood, and occasionally other body tissues [ 1 , 2 ]. (
  • Methods: CT26.WT murine colon carcinoma cells were injected intraportally in Balb/c mice after median laparotomy using a standardized injection technique. (
  • Results: Intraportal injection of colon carcinoma cells resulted in a gradual and time dependent metastatic growth. (
  • The aim of the current study was to characterize better available intestinal in vitro models by comparing expression levels of these proteins and enzymes between porcine intestine, human intestine, and Caco-2 cells. (
  • N = 9), and Caco-2 cells. (
  • Alternatively, expression level of relevant transporter proteins (glucose transporter 1, OATP4A1, MRP2, MRP1, and OATP2B1) was significantly higher (3- to 130-fold) in Caco-2 cells compared with human jejunum. (
  • Moreover, all examined CYPs showed at least a fivefold lower gene expression in Caco-2 cells compared with human jejunum, with the smallest differences for CYP1A1 and CYP3A5 and the largest difference for CYP3A4 (871-fold higher expression in human jejunum compared with Caco-2 cells). (
  • In conclusion, a comprehensive overview is provided of the expression levels of clinically relevant transporter proteins and metabolic enzymes in porcine and human intestinal tissue and Caco-2 cells, which may assist in deciding upon the most suitable model to further improve our understanding of processes that determine intestinal absorption of compounds. (
  • Caco-2 cells, HT-29 cells, Ussing chamber) and in silico methods (e.g. (
  • After incubation of the cells with NM for 24 hours, 50μL of MTT reagent in media (0.5mg/ ml) was added to each well, and further incubated for 2 hours at 37°C. The solution was carefully aspirated and the blue formazine precipitate was dissolved in 1 ml DMSO and the absorbance (OD) was measured on a microplate reader at a wavelength of 570 nm in a BioSpec 1601 Shimadzu spectrometer. (
  • Owing to the decrease of HK-2 expression, glucose uptake and lactate production in HCC cells were substantially inhibited after exposure to chrysin. (
  • Chrysin-mediated cell apoptosis and glycolysis suppression were dramatically impaired in HK-2 exogenous overexpression cells. (
  • FG carcinoma cells were grown in RPMI 1640 ( GIBCO BRL , Gaithersburg, MD) supplemented with 10% FBS, 50 μg/ml gentamicin and were free from mycoplasma during these studies. (
  • Then, the mRNA expression of several markers related to different CD4 + T cell subsets including regulatory T cells (Treg), T helper (Th) type 1, 2 and 17 were determined. (
  • Durable Response to PD-1 Blockade in a Patient With Metastatic Pancreatic Undifferentiated Carcinoma With Osteoclast-Like Giant Cells. (
  • The level of 4.5SI RNA remained steady in cells, while that of 4.5SH RNA increased 5-10 times 1-2 h after heat shock (Fig. 2A). (
  • COX-2 inhibitors, celecoxib, rofecoxib, and SC58125, blocked uptake of [ 18 F]Pyricoxib in HCA-7 cells in a concentration-dependent manner. (
  • Many avenues are being explored in an effort to develop more effective and selective treatment of patients with advanced colorectal carcinoma. (
  • Madajewicz S., Fiore J.J., Zarrabi M.H. (1988) Clinical Experience with 5-FU/DDP ± OHDW Combination Chemotherapy in Patients with Advanced Colorectal Carcinoma. (
  • However, in patients with more advanced stages, remission rates are considerably lower (2, 3). (
  • Plasma t1/2 of leukemia, otherwise in all patients in dangerously enhanced, reteplase and viagra online singapore vinblastine 5 549. (
  • Most common site of distant relapses were bone, liver and ovaries (3, 2 and 2 patients, respectively). (
  • Through suppressing glycolysis and inducing apoptosis in HCC, chrysin, or its derivative has a promising potential to be a novel therapeutic for HCC management, especially for those patients with high HK-2 expression. (
  • Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma. (
  • Environmental factors that increase the risk of developing AML include smoking, benzene exposure, and chemotherapy or radiotherapy treatment [ 1 , 2 ]. (
  • Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma? (
  • High dose radiation therapy and chemotherapy as induction treatment for stage III nonsmall cell lung carcinoma. (
  • There have been efforts to overcome these problems by modifying the drugs in different ways to circumvent these hindrance such as (1) isolate human native enzymes to reduce allergy, (2) isolate enzyme isoforms with higher specificities and efficiencies, (3) pegylate the enzymes to reduce allergy and prolong the half-lives, and (4) design drug combinations protocols to enhance the efficacy of chemotherapy by drug synergy and minimizing resistance. (
  • Dr. Messina's research interests include pathology of the sentinel node, biomarkers of prognosis in cutaneous melanoma, and etiology and treatment of Merkel cell carcinoma. (
  • Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma. (
  • In the kidney, succinylacetone has been demonstrated to be a mitochondrial toxin that inhibits substrate-level phosphorylation by means of the Krebs cycle. (
  • FH encodes an enzyme that operates in the mitochondrial Krebs cycle being thus involved in cellular energy metabolism. (
  • Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. (
  • HCC cell xenograft model was used to confirm the antitumor activity of chrysin in vivo and the effect on HK-2 was tested in chrysin-treated tumor tissue. (
  • In vitro and in vivo studies by Mukherji et al (9, 10) confirmed that increased Cho:Cr ratios were evident in pretreated squamous cell carcinoma. (
  • Standard COX-2 inhibitors were used to test for specificity of [ 18 F]Pyricoxib for COX-2 binding in vitro and in vivo. (
  • Selective COX-2-mediated tumor uptake of [ 18 F]Pyricoxib in HCA-7 xenografts was confirmed in vivo. (
  • This partial glycolytic switch is characterized by the incomplete glucose oxidation stemming from the effective diversion of pyruvate into lactate at the expense of the pyruvate supply into the tricarboxylic acid (Krebs) cycle, hence oxidative phosphorylation (OXPHOS) is decreasing or dormant. (
  • Within mitochondria, the SDH enzyme links two important pathways in energy conversion: the citric acid cycle (or Krebs cycle) and oxidative phosphorylation. (
  • Challenges in Pathologic Staging of Renal Cell Carcinoma: A Study of Interobserver Variability Among Urologic Pathologists. (
  • In this study, we investigated casein kinase 2 alpha 1 (CSNK2A1) gene and protein expression in the liver tissues of mice at different ages (4, 16, and 32 weeks) using real-time quantitative polymerase chain reactions, western blotting, immunohistochemistry, and enzyme-linked immunosorbent assay. (
  • Catalyzing enzyme: glutaminase (EC 2. (
  • The glucose analogue 2-deoxy- d -glucose (DG) inhibits glycolysis because it is phosphorylated by hexokinase, the first enzyme in glycolysis, but is not further metabolized and thus acts as a titrator of glucose. (
  • Krebs kann fast immer beherrscht werden durch die richtige Dosierung proteinverdauender Enzyme . (
  • Within mitochondria, this enzyme is involved in a series of chemical reactions known as the citric acid cycle or Krebs cycle. (
  • Cyclooxygenase-2 (COX-2) is the inducible isoform of the cyclooxygenase enzyme family. (
  • and COX-2, which is the inducible form of the enzyme. (
  • HLRCC is characterized by a predisposition to leiomyomas of the skin and the uterus as well as renal cell carcinoma. (
  • 2. The method of claim 1 in which the target gene is a cellular gene. (
  • Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity? (
  • SOX2 Gene Amplification and Overexpression is Linked to HPV-positive Vulvar Carcinomas. (
  • Phosphorylation of protein kinase B (AKT) the mitogen-activated protein kinases (MAPKs) p38 and p42/44 (extracellular signal-regulated kinase, ERK1/2) and inhibitor of kappa light chain gene enhancer alpha (IĸBα) was determined by western blotting as these events are associated with early signaling cascades. (
  • Pleomorphic lobular carcinoma: morphology, immunohistochemistry, and molecular analysis. (
  • The mucinous variant of infiltrating lobular carcinoma? (
  • Final Validation of the ProMisE Molecular Classifier for Endometrial Carcinoma in a Large Population-based Case Series. (
  • Oral absorption may recur in endometrial carcinoma, and the accepted standard for use of blood pressure. (
  • As mutacións e a sobreexpresión da β-catenina están asociadas con moitos cancros, incluíndo o carcinoma hepatocelular , cancro colorrectal , cancro pulmonar , cancro de mama , cancro de ovario e cancro endometrial . (
  • The expression of HK-2 in HCC cell line and tumor tissue was examined by western blotting and immunohistochemistry staining. (
  • Surprisingly, after 72 hr of 5% O 2 hypoxia, the AOA (bithionol) inhibition ceased and respiration was completely restored. (
  • Tauber: 'Chymotrypsin inhibition by human serum in health and disease' Exp Biol Med 74,3 486-489 7.1950 metastasierender Krebs erkennbar. (
  • Localization to the outer membrane of mitochondria confers HK-2 the advantage to escape product inhibition and gain preferential access to ATP in mitochondrion [ 6 ]. (
  • These genes include in particular DNMT3A, TET2, and IDH1/2, involved with regulation of DNA methylation, and EZH2 and ASXL-1, which are implicated in regulation of histones. (
  • Chronic interferon genes involved, which enhances the krebs. (
  • An altered metabolism is involved in the development of clear cell - renal cell carcinoma (ccRCC), and in this tumor many altered genes play a fundamental role in controlling cell metabolic activities. (
  • Tumour suppressor genes mutated in renal tumour syndromes (red, associated syndromes and renal tumour type listed together) converge on the oxygen‐sensing pathway and TCA/Krebs cycle. (
  • Signet ring cell carcinoma (SRCC) of breast is a rare subtype with aggressive clinical course. (
  • Lepr db / + Lepr db mice, T2DM, Casein Kinase 2 Alpha 1 (CSNK2A1). (
  • Notably, BKS.Cg- Dock7 m +/+ Lepr db /JNarl mice are useful animal models for studying type 2 diabetes mellitus (T2DM). (
  • While we have recently demonstrated the ability of the novel kefir product PFT (Probiotics Fermentation Technology) to exert anticancer effects in vitro, here we demonstrate its ability to inhibit Ehrlich ascites carcinoma (EAC) in mice. (
  • The radiotracer was slowly metabolized in mice, with approximately 60 % of intact compound after 2 h post-injection. (
  • A phase II trial of continuous infusion 5-FU and weekly low dose cisplatin in colorectal carcinoma. (
  • Phosphorylation of tyrosine residues on the epidermal growth factor (EGF) receptor (EGFr) is an important early event in signal transduction, leading to cell replication for major human carcinomas. (
  • The protein kinase casein kinase 2 (CSNK2 or CK2) is a serine/threonine protein kinase that is expressed in most cell types [ 1 ] . (
  • Tumor cell resistance to these drugs may involve reduced cellular accumulation, altered drug metabolism, altered DNA repair, and up-regulated cell survival pathways ( 2 ). (
  • Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma. (
  • Loss of activity of the Krebs cycle components succinate dehydrogenase (SDH) complex or fumarate hydratase (FH), has been identified as a mechanism of tumorigenesis in subsets of gastrointestinal stromal tumor (GIST), pheochromocytoma and paraganglioma (PHEO/PGL), and renal cell carcinoma. (
  • This study dissects the renal cell carcinoma tumor microenvironment by leveraging tumorgrafts. (
  • A unique synthetic lethal screening strategy identified a drug with activity against VHL-deficient ccRCC that could be repurposed for renal cell carcinoma. (
  • A rare form of adenocarcinoma, known as clear cell carcinoma, occurs in association with in utero exposure to DES, with a peak incidence before age 30 years. (
  • Carcinoma, Squamous Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (
  • This graph shows the total number of publications written about "Carcinoma, Squamous Cell" by people in Harvard Catalyst Profiles by year, and whether "Carcinoma, Squamous Cell" was a major or minor topic of these publication. (
  • Below are the most recent publications written about "Carcinoma, Squamous Cell" by people in Profiles. (
  • Signet-ring cell carcinoma of the breast: a clinicopathologic study of 24 cases. (
  • Poorer Prognosis of Primary Signet-Ring Cell Carcinoma of the Breast Compared with Mucinous Carcinoma. (
  • 6. Liu SM, Chen DR. Signet-ring cell carcinoma of the breast. (
  • 7. Kondo Y, Akita T, Sugano I, Isono K. Signet ring cell carcinoma of the breast. (
  • Resection Margins in Merkel Cell Carcinoma: Is a 1-cm Margin Wide Enough? (
  • After the first successful report by Lim and Sun in 1980 ( 2 ), an increasing number of investigations have focused their interest on the cell-encapsulating devices for the treatment of wide range of diseases, such as hormone deficiencies and neurodegenerative disorders ( 3 ). (
  • Cell proliferation was evaluated by MTT assay, invasion through Matrigel™, MMP secretion was evaluated by zymography, and COX-2 and COX-1 expression by Western blot. (
  • The effect of chrysin on HK-2 expression and the underlying mechanisms by which induced HCC cell apoptosis were studied. (
  • In HK-2 exogenous overexpression cell, the changes of chrysin-induced cell apoptosis and glycolysis suppression were investigated. (
  • In contrast with normal cell lines and tissue, HK-2 expression was substantially elevated in the majority of tested HCC cell lines and tumor tissue. (
  • After chrysin treatment, HK-2 which combined with VDAC-1 on mitochondria was significantly declined, resulting in the transfer of Bax from cytoplasm to mitochondria and induction of cell apoptosis. (
  • Susceptibility to early-onset renal cell carcinoma and uterine leiomyosarcoma is present in a subset of families. (
  • The remaining 25% of renal cell carcinoma (RCC) has distinct, yet related, molecular mechanisms, which are just beginning to be understood. (
  • There are several subtypes of renal cell carcinoma (RCC), each associated with distinct molecular genetics. (
  • The cell borders are often more distinct in this carcinoma than others and the nuclei are often smaller and darker. (
  • Schematic of clear cell renal cell carcinoma progression. (
  • Silverstein, M.J.: Intraductal Breast Carcinoma. (
  • A suggested positive control is breast carcinoma. (
  • 3. Merino MJ, Livolsi VA. Signet ring carcinoma of the female breast: a clinicopathologic analysis of 24 cases. (
  • In addition, metabolites related to pentose phosphate pathway were also altered in the tumor samples in association with changes in Krebs cycle intermediates and related metabolites. (
  • In Warburg effect, even in the presence of sufficient oxygen, glucose is converted to lactate, instead of totally oxidized via Krebs cycle to generate ATP [ 2 ]. (
  • So far, various regulatory pathways involved in the conversion from the Krebs cycle to tumor glycolysis have been well investigated, HKs were considered to be one of the most important effectors [ 4 , 5 ]. (
  • Mutations in SUCLA2: a tandem ride back to the Krebs cycle. (
  • Lac is a redox partner of pyruvate, which is a metabolic intermediate between glycolysis and the Krebs or tricarboxylic acid cycle. (
  • There is a component of krebs cycle and also occasionally from n, n, and rem sleep. (
  • Women who have had a hysterectomy for benign, premalignant, or malignant disease are at risk of vaginal carcinomas. (