Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Carcinoma
Carcinoma, Squamous Cell
alpha-Fetoproteins
Carcinoma in Situ
Chemoembolization, Therapeutic
Carcinoma, Papillary
Liver Cirrhosis
Immunohistochemistry
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Liver
Carcinoma, Ductal, Breast
Gene Expression Regulation, Neoplastic
Carcinoma, Basal Cell
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Prognosis
Hep G2 Cells
Neoplasm Staging
Carcinoma, Transitional Cell
Tumor Cells, Cultured
Neoplasm Recurrence, Local
Iodized Oil
Carcinoma, Bronchogenic
Carcinoma, Intraductal, Noninfiltrating
Carcinoma, Adenoid Cystic
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Treatment Outcome
Niacinamide
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Carcinoma, Small Cell
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Mice, Nude
Carcinoma, Medullary
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Hepatitis B
Carcinoma, Lobular
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Survival Rate
Liver Transplantation
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Neoplasm Metastasis
Carcinoma, Neuroendocrine
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Hepatitis B virus
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Glypicans
Hepatocytes
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Reverse Transcriptase Polymerase Chain Reaction
Disease Progression
Hepatitis B, Chronic
Tomography, X-Ray Computed
Precancerous Conditions
Neoplasm Transplantation
Carcinoma, Mucoepidermoid
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
Ethiodized Oil
Immunoenzyme Techniques
Lymphatic Metastasis
Carcinoma, Endometrioid
Head and Neck Neoplasms
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Neoplasms, Multiple Primary
Carcinoma, Embryonal
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Antigens, Neoplasm
Tumor Suppressor Protein p53
Carcinoma, Merkel Cell
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Hepatitis C
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Carcinoma, Ductal
Ovarian Neoplasms
Disease-Free Survival
Tumor Burden
Focal Nodular Hyperplasia
Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. The nodule, poorly encapsulated, consists of a central stellate fibrous scar and normal liver elements such as HEPATOCYTES, small BILE DUCTS, and KUPFFER CELLS among the intervening fibrous septa. The pale colored central scar represents large blood vessels with hyperplastic fibromuscular layer and narrowing lumen.
Adrenocortical Carcinoma
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Carcinoma, Verrucous
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
Hepatitis, Chronic
Carcinoma, Signet Ring Cell
Cell Transformation, Neoplastic
Follow-Up Studies
Blotting, Western
Risk Factors
Fatal Outcome
Cell Division
Combined Modality Therapy
Mutation
Hepatitis B Surface Antigens
Aflatoxin B1
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
Genes, p53
Gene Expression Profiling
Tissue Array Analysis
Base Sequence
Hepatic Artery
Carcinoma, Large Cell
Neovascularization, Pathologic
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Carcinogens
Down-Regulation
Biopsy
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Xenograft Model Antitumor Assays
Laryngeal Neoplasms
Sensitivity and Specificity
Up-Regulation
Catheter Ablation
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Hepatitis C, Chronic
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Adenocarcinoma, Follicular
Multivariate Analysis
Gene Expression
Transfection
Adenocarcinoma, Mucinous
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Loss of Heterozygosity
Colorectal Neoplasms
Ki-67 Antigen
Cell Survival
Promoter Regions, Genetic
Embryonal Carcinoma Stem Cells
Keratins
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Oligonucleotide Array Sequence Analysis
Genes, Tumor Suppressor
Neoplasms, Experimental
Hepatoblastoma
Carcinoma, Papillary, Follicular
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Bile Ducts, Intrahepatic
Hepacivirus
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Carcinoma, Non-Small-Cell Lung
Dose-Response Relationship, Drug
Keratin-7
Cadherins
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Endometrial Neoplasms
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Aflatoxins
Furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2.
Liver Function Tests
Adenocarcinoma, Clear Cell
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Infusions, Intra-Arterial
Fluorouracil
Cell Movement
Alanine Transaminase
Tumor Suppressor Proteins
Proportional Hazards Models
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Antineoplastic Combined Chemotherapy Protocols
Pyridines
Liver Cirrhosis, Alcoholic
Carcinogenicity Tests
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
Cystadenocarcinoma, Serous
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Carcinoma, Lewis Lung
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
Drug-Induced Liver Injury
Prospective Studies
MicroRNAs
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Trans-Activators
Incidence
Hyperplasia
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Neoplasm Grading
Embolization, Therapeutic
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. (1/11254)
OBJECTIVE: This study aimed to evaluate the long-term results of treatment and prognostic factors in patients with intrahepatic recurrence after curative resection of hepatocellular carcinoma (HCC). SUMMARY BACKGROUND DATA: Recent studies have demonstrated the usefulness of re-resection, transarterial oily chemoembolization (TOCE), or percutaneous ethanol injection therapy (PEIT) in selected patients with intrahepatic recurrent HCC. The overall results of a treatment strategy combining these modalities have not been fully evaluated, and the prognostic factors determining survival in these patients remain to be clarified. METHODS: Two hundred and forty-four patients who underwent curative resection for HCC were followed for intrahepatic recurrence, which was treated aggressively with a strategy including different modalities. Survival results after recurrence and from initial hepatectomy were analyzed, and prognostic factors were determined by univariate and multivariate analysis using 27 clinicopathologic variables. RESULTS: One hundred and five patients (43%) with intrahepatic recurrence were treated with re-resection (11), TOCE (71), PEIT (6), systemic chemotherapy (8) or conservatively (9). The overall 1-year, 3-year, and 5-year survival rates from the time of recurrence were 65.5%, 34.9%, and 19.7%, respectively, and from the time of initial hepatectomy were 78.4%, 47.2%, and 30.9%, respectively. The re-resection group had the best survival, followed by the TOCE group. Multivariate analysis revealed Child's B or C grading, serum albumin < or = 40 g/l, multiple recurrent tumors, recurrence < or = 1 year after hepatectomy, and concurrent extrahepatic recurrence to be independent adverse prognostic factors. CONCLUSIONS: Aggressive treatment with a multimodality strategy could result in prolonged survival in patients with intrahepatic recurrence after curative resection for HCC. Prognosis was determined by the liver function status, interval to recurrence, number of recurrent tumors, any concurrent extrahepatic recurrence, and type of treatment. (+info)Identification of a cAMP response element within the glucose- 6-phosphatase hydrolytic subunit gene promoter which is involved in the transcriptional regulation by cAMP and glucocorticoids in H4IIE hepatoma cells. (2/11254)
The expression of a luciferase reporter gene under the control of the human glucose 6-phosphatase gene promoter was stimulated by both dexamethasone and dibutyryl cAMP in H4IIE hepatoma cells. A cis-active element located between nucleotides -161 and -152 in the glucose 6-phosphatase gene promoter was identified and found to be necessary for both basal reporter-gene expression and induction of expression by both dibutyryl cAMP and dexamethasone. Nucleotides -161 to -152 were functionally replaced by the consensus sequence for a cAMP response element. An antibody against the cAMP response element-binding protein caused a supershift in gel-electrophoretic-mobility-shift assays using an oligonucleotide probe representing the glucose 6-phosphatase gene promoter from nucleotides -161 to -152. These results strongly indicate that in H4IIE cells the glucose 6-phosphatase gene-promoter sequence from -161 to -152 is a cAMP response element which is important for the regulation of transcription of the glucose 6-phosphatase gene by both cAMP and glucocorticoids. (+info)Tumour ablation and hepatic decompensation rates in multi-agent chemoembolization of hepatocellular carcinoma. (3/11254)
Thirty-seven cirrhotic patients with 62 hepatocellular carcinoma (HCC) foci--most Child-Pugh class B or C and/or with large, inoperable tumours--underwent 148 sessions of transcatheter arterial chemoembolization (TACE) using lipiodol, doxorubicin and cisplatin. Treatment efficacy was assessed by serial hepatic arteriography in 34/37 (91.9%) patients and abdominal CT scanning in 3/37 (8.1%) patients. Child-Pugh status was determined prior to each treatment session. Varying degrees of control of tumour neovascularity occurred for a median 390 days (range 90 to > 1680 days) in 33/34 (97.1%) patients in whom progress hepatic arteriography was performed. Ablation of tumour neovascularity occurred in 6/6 (100%), 4/12 (33.3%) and 6/16 (37.5%) patients with HCC diameters < 4 cm, 4-7 cm and > 8 cm, respectively (p < 0.02). Significantly more sessions were required for ablation of larger tumours (p < 0.05). Recurrent HCC was detected in 50% of patients after a median 240 days (range 60-1120 days). Deterioration in Child-Pugh status followed a session of TACE on 19/148 (12.8%) occasions but resulted in unscheduled hospitalization on only 4/148 (2.7%) occasions, the highest incidence (8.3%) in Child-Pugh C patients. Actuarial survival was 27/36 (75.0%) at 6 months, 17/34 (50.0%) at 12 months, 14/34 (41.2%) at 18 months, 9/31 (29.0%) at 24 months and 4/27 (14.8%) at 36 months. Multi-agent TACE with lipiodol, doxorubicin and cisplatin provides a useful anti-tumour effect, even in cirrhotic patients with large HCCs. The incidence of clinically significant deterioration in hepatic function due to ischaemia of non-tumorous liver is acceptably low, even in Child-Pugh C patients. (+info)Clinical significance of circulating anti-p53 antibodies in European patients with hepatocellular carcinoma. (4/11254)
p53 alterations are considered to be predictive of poor prognosis in hepatocellular carcinoma (HCC) and may induce a humoral response. Anti-p53 serum antibodies were assessed by enzyme-linked immunosorbent assay (ELISA) using purified recombinant human p53 on 130 European HCC patients before treatment and during the clinical course of the disease. p53 immunohistochemistry was performed on tumours from the 52 patients who underwent surgery, and DNA sequencing analysis was initiated when circulating anti-p53 antibodies were detected. Nine (7%) HCC patients had anti-p53 serum antibodies before treatment. During a mean period of 30 months of follow-up, all the negative patients remained negative, even when recurrence was observed. Of the nine positive patients, eight were still positive 12-30 months after surgery. The presence of anti-p53 serum antibodies was correlated neither with mutation of the p53 gene nor the serum alpha-fetoprotein levels and clinicopathological characteristics of the tumours. However, a greater incidence of vascular invasion and accumulation of p53 protein were observed in the tumours of these patients (P<0.03 and P<0.01 respectively) as well as a better survival rate without recurrence (P = 0.05). In conclusion, as was recently shown in pancreatic cancer, anti-p53 serum antibodies may constitute a marker of relative 'good prognosis' in a subgroup of patients exhibiting one or several markers traditionally thought to be of bad prognosis. (+info)Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. (5/11254)
Wild-type (wt) p53 frequently induces apoptosis when expressed in tumor cells whereas mutant p53 acts as an oncoprotein and consequently, stimulates cell proliferation. We report here exceptions to that rule. p53 conformational mutant 175H and DNA contact mutant 273H provoke apoptosis in human p53-deficient Hep3B hepatoma cells with delayed kinetics relative to wt p53. Similarly, c-Myc strongly stimulates apoptosis in these cells. In contrast, viral oncoproteins E1A and E7, and the cellular oncoprotein MDM-2, fail to elicit cytocidal responses. Efficient apoptotic cell death by mutant p53 requires oligomerization as 175H and 273H with deletions between amino acid residues 326 and 347 of the oligomerization domain are nontoxic. Apoptosis by mutant or wt p53 was significantly inhibited by the serine protease inhibitor AEBSF but not by the inactive analog AEBSA. Together, these results suggest that a wt p53-independent control mechanism is operational in Hep3B cells that eliminates cells upon sensing illegitimate proliferation signals originating from certain oncoproteins, including mutant p53 and Myc. We suggest that some tumor cell types lack p53 altogether because they tolerate neither wild-type nor mutant forms of the protein. (+info)Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease. (6/11254)
Rats bearing the Zajdela hepatoma tumor and T3-treated hypothyroid rats were used to study the role of protein degradation in the process of mitochondrial biogenesis. It was shown that the activity, protein and mRNA levels of the ATP-dependent Lon protease increased in rapidly growing Zajdela hepatoma cells. The increase in the rate of mitochondrial biogenesis by thyroid hormone was similarly accompanied by enhanced expression of the Lon protease. The results imply that mitochondrial biogenesis in mammalian cells is, at least partially, regulated by the matrix Lon protease. (+info)Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2. (7/11254)
1. Previous studies of the regulation of the alpha2C-adrenoceptor in OK and in transfected cells have led to discrepant conclusions. In the present work, we examined the homologous regulation of the human alpha2C-adrenoceptor in the hepatocarcinoma cell-line, HepG2; a model which expresses this subtype spontaneously. 2. Short-period treatment of the cells with UK14304 provoked neither a diminution of the potency of the alpha2-agonist to inhibit forskolin-induced cyclic AMP-accumulation nor a change in the degree of receptor coupling to G-proteins. 3. Long-period exposure to UK14304 resulted in a large reduction of [3H]MK912 binding sites (55% decrease). The action of UK14304 was dose-dependent (EC50 = 190 +/- 45 nM), rapid (t1/2 = 4.2 h) and reversible. Receptor down-regulation was also observed with clonidine or (-)adrenaline (38 and 36% decrease, respectively) and was blocked by the addition of alpha2-antagonists. 4. Conversely to that observed with alpha2-agonists, treatment of the cells with RX821002 or yohimbine alone, but not with phentolamine, promoted a significant increase of the receptor expression. 5. The observed alterations of receptor density are not the reflection of changes at the alpha2C4 mRNA level. Estimation of the receptor protein turnover and measurement of its half-life demonstrated that down-regulation by alpha2-agonists and up-regulation by alpha2-antagonists, with inverse-agonist efficacy, are respectively the consequence of increased and decreased rate of receptor degradation. 6. In conclusion, our data show that alpha2C-adrenoceptor does not undergo desensitization but is down-regulated in HepG2. The lack of desensitization agrees with previous results obtained in cells transfected with the alpha2C4 gene, but not with observations made in OK cells. Inversely, down-regulation fits with results obtained in OK but not in transfected cells. The reasons for these discrepancies are discussed. Our results also demonstrated that certain alpha2-antagonists behave as inverse agonist on the HepG2 model and thus provide for the first time evidence of inverse efficacy of antagonists on a cellular model expressing physiological level of a wild-type alpha2-adrenoceptor. (+info)Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake. (8/11254)
The liver-type fatty acid binding protein (L-FABP), a member of a family of mostly cytosolic 14-15 kDa proteins known to bind fatty acids in vitro and in vivo, is discussed to play a role in fatty acid uptake. Cells of the hepatoma HepG2 cell line endogenously express this protein to approximately 0.2% of cytosolic proteins and served as a model to study the effect of L-FABP on fatty acid uptake, by manipulating L-FABP expression in two approaches. First, L-FABP content was more than doubled upon treating the cells with the potent peroxisome proliferators bezafibrate and Wy14,643 and incubation of these cells with [1-14C]oleic acid led to an increase in fatty acid uptake rate from 0.55 to 0.74 and 0.98 nmol/min per mg protein, respectively. In the second approach L-FABP expression was reduced by stable transfection with antisense L-FABP mRNA yielding seven clones with L-FABP contents ranging from 0.03% to 0.14% of cytosolic proteins. This reduction to one sixth of normal L-FABP content reduced the rate of [1-14C]oleic acid uptake from 0.55 to 0. 19 nmol/min per mg protein, i.e., by 66%. The analysis of peroxisome proliferator-treated cells and L-FABP mRNA antisense clones revealed a direct correlation between L-FABP content and fatty acid uptake. (+info)
Fibrolamellar hepatocellular carcinoma - wikidoc
Metastatic Hepatocellular Carcinoma (HCC) Market - Revenue, Demands, Industry Analysis, Trends, Growth, and Forecast, 2016 -...
First-time use of bevacizumab for aggressive, metastatic hepatocellular carcinoma in an HIV/hepatitis B virus coinfected...
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Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics<...
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Fibrolamellar hepatocellular carcinoma - Wikipedia
Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma. | Sigma-Aldrich
The secondary prevention of hepatitis B virus-associated hepatocellular carcinoma
HCV Research and News: Chemoprevention of hepatocellular carcinoma in chronic hepatitis C
Evaluation of Midkine as a Diagnostic Serum Biomarker in Hepatocellular Carcinoma | Clinical Cancer Research
Synapse - Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma
European Cases of Fibrolamellar Hepatocellular Carcinoma | Annals of Internal Medicine | American College of Physicians
Frontiers | Dysregulated microRNAs in Hepatitis B Virus-Related Hepatocellular Carcinoma: Potential as Biomarkers and...
Dynamic monitoring of serum alpha-fetoprotein and its correlation with early hepatocellular carcinoma in patients with chronic...
Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine.
Altered findings of hepatic arteriography after radiofrequency ablation of hepatocellular carcinoma: Comparison of pre-ablation...
The cytotoxic effect of E1B 55-kDa mutant adenovirus on human hepatocellular carcinoma cell lines - Ludwig Cancer Research
Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells<...
Ferucarbotran-enhanced MRI versus triple-phase MDCT for the preoperative detection of hepatocellular carcinoma<...
miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway
Hepatocellular carcinoma. Causes, symptoms, treatment Hepatocellular carcinoma
Lipocalin-2 Induces Apoptosis in Human Hepatocellular Carcinoma Cells Through Activation of Mitochondria Pathways<...
Circulating microRNA-301 as a promising diagnostic biomarker of hepatitis C virus-related hepatocellular carcinoma |...
Shoulder Mass as the Initial Presentation of Metastatic Hepatocellular Carcinoma | ACG Case Reports Journal - An online journal...
Significance of PIVKA-II in sorafenib therapy for advanced hepatocellular carcinoma<...
Systemic cytotoxic chemotherapy of patients with advanced hepatocellular carcinoma in the era of sorafenib nonavailability<...
Recurrent hepatocellular carcinoma after liver transplant: Identifying the high-risk patient<...
Combination chemotherapy with continuous 5-fluorouracil and low-dose cisplatin infusion for advanced hepatocellular carcinoma<...
Gentaur Molecular :US Biomax \ Hepatocellular carcinoma tissue array, 63 cases 63 cores, replaced by LV809 \ BS03014
Drug Monitoring of Sorafenib in Patients With Advanced Hepatocellular Carcinoma - Full Text View - ClinicalTrials.gov
Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated...
Fulminant hepatitis in a patient with hepatocellular carcinoma related to nonalcoholic steatohepatitis treated with sorafenib |...
Surgical Resection vs. Ablative Therapies Through a Laparoscopic Approach for Hepatocellular Carcinoma: a Comparative Study<...
HKU Scholars Hub: Recombinant interferon-α in inoperable hepatocellular carcinoma: A randomized controlled trial
Treatment of small hepatocellular carcinoma near the top of diaphragm with CT-guided percutaneons radiofrequency ablation--...
An overview of loco-regional treatments in patients and mouse models for hepatocellular carcinoma<...
Serum Endocan as a Novel Prognostic Biomarker in Patients with Hepatocellular Carcinoma
Epidemiology and outcome of hepatocellular carcinoma in Lombardy | Archivio Istituzionale della Ricerca
The association of leptin and adiponectin with hepatocellular carcinoma risk and prognosis: a combination of traditional,...
Fibrolamellar hepatocellular carcinoma at a tertiary centre in South Africa: A case series
The value of dynamic subtraction MRI technique in the assessment of treatment response of hepatocellular carcinoma to...
C7 peptide inhibits hepatocellular carcinoma metastasis by tar...
Early Recurrence Of Hepatocellular Carcinoma Following Transplantation: Risk Score From A Multi-institutional Study Of | 3000...
Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients<...
Diagnostics | Free Full-Text | Hepatocellular Carcinoma, Fibrolamellar Variant: Diagnostic Pathologic Criteria and Molecular...
Hypofractionated radiotherapy as a salvage treatment for recurrent hepatocellular carcinoma with inferior vena cava/right...
CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor...
Safety and efficacy of TACE and gamma knife on hepatocellular carcinoma with portal vein invasion | Gut
Cirrhosis
... leading to hepatocellular carcinoma (autopsy specimen) However, cirrhosis is defined by its pathological features on ... Ultrasound may also screen for hepatocellular carcinoma, and portal hypertension, by assessing flow in the hepatic vein. An ... Forner A, Llovet JM, Bruix J (2012). "Hepatocellular carcinoma". The Lancet. 379 (9822): 1245-1255. doi:10.1016/S0140-6736(11) ... Singal AG, Pillai A, Tiro J (2014). "Early detection, curative treatment, and survival rates for hepatocellular carcinoma ...
Hepatitis B
This population has a 40% lifetime risk of death from cirrhosis or hepatocellular carcinoma. Of those infected between the age ... This type of infection dramatically increases the incidence of hepatocellular carcinoma (HCC; liver cancer). Across Europe, ... El-Serag HB (22 September 2011). "Hepatocellular carcinoma". New England Journal of Medicine. 365 (12): 1118-27. doi:10.1056/ ... El-Serag HB, Rudolph KL (June 2007). "Hepatocellular carcinoma: epidemiology and molecular carcinogenesis". Gastroenterology. ...
RNA-targeting small molecule drugs
and hepatocellular carcinoma. More recently, the Disney group further used their prediction database INFORNA to design ... "Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma". ACS Chemical Biology. 11 (2): 375-80. doi: ...
Liver cancer
... of hepatocellular carcinoma (HCC). Men with chronic HCV or HBV are more likely to develop hepatocellular carcinoma than women ... "Hepatocellular carcinoma: a review". Journal of Hepatocellular Carcinoma. 3: 41-53. doi:10.2147/JHC.S61146. ISSN 2253-5969. PMC ... For example, it is recommended that people with chronic liver disease who are at risk for hepatocellular carcinoma be screened ... Hepatocellular carcinoma is associated with abdominal mass, abdominal pain, emesis, anemia, back pain, jaundice, itching, ...
Yu Baofa
Journal of Hepatocellular Carcinoma. 2: 57-68. doi:10.2147/JHC.S80756. PMC 4918285. PMID 27508195. Yu, Baofa; Lu, Yuanfei; Gao ... Journal of Hepatocellular Carcinoma. 2: 57-68. doi:10.2147/JHC.S80756. PMC 4918285. PMID 27508195. "Hospital offers service to ... "Hapten-enhanced overall survival time in advanced hepatocellular carcinoma by ultro-minimum incision personalized intratumoral ... "Hapten-enhanced overall survival time in advanced hepatocellular carcinoma by ultro-minimum incision personalized intratumoral ...
Glypican
Pang RW, Joh JW, Johnson PJ, Monden M, Pawlik TM, Poon RT (April 2008). "Biology of hepatocellular carcinoma". Annals of ... Abnormal expression of glypicans has been noted in multiple types of cancer, including human hepatocellular carcinoma, ovarian ... "A Frizzled-Like Cysteine-Rich Domain in Glypican-3 Mediates Wnt Binding and Regulates Hepatocellular Carcinoma Tumor Growth in ... while GPC3 expression occurs in the majority of human hepatocellular carcinomas. A similar correlation has been found in ...
European Association for the Study of the Liver
"Hepatocellular Carcinoma EASL Guideline". EASL-The Home of Hepatology. "Management of Alcohol-Related Liver Disease". EASL-The ...
Cancer biomarker
CS1 maint: discouraged parameter (link) Behne, Tara; Copur, M. Sitki (1 January 2012). "Biomarkers for Hepatocellular Carcinoma ... a marker indicating a patient's non-small-cell lung carcinoma (NSCLC) will likely respond to gefitinib or erlotinib treatment. ... "Distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma". Journal of ... "Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study". Cancer. 123 ...
Long-term effects of alcohol
Morgan TR, Mandayam S, Jamal MM (November 2004). "Alcohol and hepatocellular carcinoma". Gastroenterology. 127 (5 Suppl 1): S87 ... Voigt MD (February 2005). "Alcohol in hepatocellular cancer". Clin Liver Dis. 9 (1): 151-69. doi:10.1016/j.cld.2004.10.003. ... especially with respect to squamous cell carcinoma of the esophagus, oropharyngeal cancer, and breast cancer. Acetaldehyde, a ... day observed that this level of alcohol consumption was still associated with some elevated risk for squamous cell carcinoma of ...
Iron overload
The presence of cirrhosis increases the risk of hepatocellular carcinoma. HHC is most common in certain European populations ( ... Kowdley, KV (November 2004). "Iron, hemochromatosis, and hepatocellular carcinoma". Gastroenterology. 127 (5 Suppl 1): S79-86. ...
Paul W. Ewald
Michielsen, Peter P; Francque, Sven M; Van Dongen, Jurgen L (2005). "Viral hepatitis and hepatocellular carcinoma". World ...
HPG80
"Expression and processing of gastrin in patients with hepatocellular carcinoma, fibrolamellar carcinoma and cholangiocarcinoma ... Carr, Brian I; Pancoska, Petr; Branch, Robert A (2010-02-25). "Low alpha-fetoprotein hepatocellular carcinoma". Journal of ... be improved by measuring hPG80 levels as a complementary blood biomarker in a cohort of patients with hepatocellular carcinoma ... It has been observed that hPG80 concentrations are increased in patients at risk of developing colorectal carcinoma. In ...
Mallory body
Mallory bodies in hepatocellular carcinoma. Trichrome stain. "Cell Injury". Denk, H; Franke, WW; Eckerstorfer, R; Schmid, E; ... hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions. However, it has also been reported in certain ...
Infections associated with diseases
Michielsen, Peter P; Francque, Sven M; Van Dongen, Jurgen L (2005). "Viral hepatitis and hepatocellular carcinoma". World ... H Salim, Omer E; Hamid, Hytham K S; Mekki, Salwa O; Suleiman, Suleiman H; Ibrahim, Shakir Z (2010). "Colorectal carcinoma ... February 2012). "Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma". Genome Research. 22 (2): 299- ...
Liver tumor
"Malignant transformation of hepatocellular adenomas into hepatocellular carcinomas: a systematic review including more than ... but the best available data suggests that the risk of hepatocellular adenoma becoming hepatocellular carcinoma, which is ... Transformation to hepatocellular carcinoma is more common in men. Currently, if the hepatic adenoma is >5 cm, increasing in ... Zhao YJ, Ju Q, Li GC (2013). "Tumor markers for hepatocellular carcinoma". Mol Clin Oncol. 1 (4): 593-598. doi:10.3892/mco. ...
Santosh G. Honavar
"Orbital metastasis from hepatocellular carcinoma". Surv Ophthalmol. 50 (5): 485-9. doi:10.1016/j.survophthal.2005.06.014. PMID ... Honavar SG (2018). "Sebaceous gland carcinoma: Can we do better?". Indian J Ophthalmol. 66 (9): 1235-1237. doi:10.4103/ijo.IJO_ ... Mulay K, White VA, Shah SJ, Honavar SG (2014). "Sebaceous carcinoma: clinicopathologic features and diagnostic role of ... "Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker". Histopathology. 62 (6 ...
Interventional radiology
"Phase 3 Study of ThermoDox With Radiofrequency Ablation (RFA) in Treatment of Hepatocellular Carcinoma (HCC) - Full Text View ... The most common indication is for treatment of unresectable liver cancer (hepatocellular carcinoma). Transarterial ... Salem, Riad; Lewandowski, Robert J. (June 2013). "Chemoembolization and radioembolization for hepatocellular carcinoma". ... primary liver tumors such as hepatocellular carcinoma or cholangiocarcinoma and liver metastases are often treated by ...
Cabozantinib
... renal cell carcinoma, and hepatocellular carcinoma. It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, ... In January 2019, the FDA approved cabozantinib (Cabometyx, Exelixis, Inc.) for people with hepatocellular carcinoma (HCC) who ... "FDA approves cabozantinib for hepatocellular carcinoma". U.S. Food and Drug Administration (FDA). 14 January 2019. Retrieved 23 ... vs Placebo in Subjects With Hepatocellular Carcinoma Who Have Received Prior Sorafenib (CELESTIAL)" at ClinicalTrials.gov ...
R. Palmer Beasley
Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22,707 men in Taiwan. Lancet 1981;2(8256):1129-1133 " ... His longitudinal observations were the first to demonstrate that hepatocellular carcinoma was prevented in Taiwanese males by ... making hepatocellular carcinoma and cirrhosis of the liver-one of the primary causes of death for much of the developing world ... cirrhosis and hepatocellular carcinoma." Dr. Beasley "demonstrated the efficacy of hepatitis B immune globulin in blocking ...
Hep G2
2015). "Poly(vinyl alcohol)/gelatin Hydrogels Cultured with Hep G2 Cells as a 3D Model of Hepatocellular Carcinoma: A ... Fanelli, Alex (2016). "HepG2 (liver hepatocellular carcinoma): cell culture". Retrieved 3 December 2017. Mersch-Sundermann, V ... 1975 from the liver tissue of a 15-year-old Caucasian male from Argentina with a well-differentiated hepatocellular carcinoma. ... 1979). "Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line". Nature. 282 (5739): 615-616 ...
Oncovirus
Although this agent was the clear cause of hepatitis and might contribute to liver cancer hepatocellular carcinoma, this link ... Beasley RP, Hwang LY, Lin CC, Chien CS (November 1981). "Hepatocellular carcinoma and hepatitis B virus. A prospective study of ... The hepatitis B vaccine is the first vaccine that has been established to prevent cancer (hepatocellular carcinoma) by ... HCV was subsequently shown to be a major contributor to Hepatocellular carcinoma (liver cancer) worldwide. In 1994 Patrick S. ...
Ramucirumab
On 10 May 2019, ramucirumab was approved by FDA as a single agent treatment for hepatocellular carcinoma (HCC) in patients who ... Research, Center for Drug Evaluation and (2019-05-10). "FDA approves ramucirumab for hepatocellular carcinoma". FDA. "Cyramza: ... Levitan D (February 2016). "Added to Docetaxel Extends PFS in Urothelial Carcinoma". Cancer Network. Clinical trial number ... with metastatic colorectal carcinoma (CRC) progressive during or following first-line combination therapy with bevacizumab (bev ...
Michael Houghton (virologist)
"Hepatitis C virus infection is associated with the development of hepatocellular carcinoma". Proc. Natl. Acad. Sci. USA. 87 (17 ... "Hepatitis C HCV associated hepatocellular carcinoma". Hepatology. 10 (4): 589-91. doi:10.1002/hep.1840100432. PMID 2169456. De ...
Yttrium
Also see radioembolization in the case of combined cirrhosis and hepatocellular carcinoma. Needles made of yttrium-90, which ... Salem, R; Lewandowski, R. J (2013). "Chemoembolization and Radioembolization for Hepatocellular Carcinoma". Clinical ... A technique called radioembolization is used to treat hepatocellular carcinoma and liver metastasis. Radioembolization is a low ...
Sorafenib
... is indicated as a treatment for advanced renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and ... hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma. Sorafenib is a ... Keating GM, Santoro A (2009). "Sorafenib: a review of its use in advanced hepatocellular carcinoma". Drugs. 69 (2): 223-40. doi ... FDA Approval letter for use of sorafenib in inoperable hepatocellular carcinoma "Liver drug 'too expensive'". BBC News. ...
Alcohol and cancer
A study of the influence of alcohol intake on tumor growth of hepatocellular carcinoma (HCC) in patients with type C cirrhosis ... Matsuhashi T, Yamada N, Shinzawa H, Takahashi T (June 1996). "Effect of alcohol on tumor growth of hepatocellular carcinoma ... September 1997). "Hepatitis B and C virus infection, alcohol drinking, and hepatocellular carcinoma: a case-control study in ... April 2006). "Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy". Cancer ...
Aflatoxin B1
Prevalence of hepatocellular carcinoma in individuals exposed to aflatoxin, increases with co-infection of hepatitis B virus. ... Up to 44% of hepatocellular carcinomas in regions with high aflatoxin exposure bear a GC → TA transversion at codon 249 of p53 ... Aflatoxin B1 is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans.[ ... Kew, MC (September 2013). "Aflatoxins as a cause of hepatocellular carcinoma". Journal of Gastrointestinal and Liver Diseases. ...
Side effects of cyproterone acetate
Watanabe S, Yamasaki S, Tanae A, Hibi I, Honna T (December 1994). "Three cases of hepatocellular carcinoma among cyproterone ... Ohri SK, Gaer JA, Keane PF (February 1991). "Hepatocellular carcinoma and treatment with cyproterone acetate". Br J Urol. 67 (2 ... Kattan J, Spatz A, Culine S, Terrier-Lacombe MJ, Elias D, Droz JP (October 1994). "Hepatocellular carcinoma during ... Rüdiger T, Beckmann J, Queisser W (February 1995). "Hepatocellular carcinoma after treatment with cyproterone acetate combined ...
Reptilase time
Johnson PJ, White Y, Woolf IL, Williams R (October 1977). "Reptilase time in cirrhosis and hepatocellular carcinoma". Br Med J ...
Catenin
... and EMT interactions may also play a role in hepatocellular carcinoma. VEGF-B treatment of hepatoma carcinoma cells can ... In another example, Wnt/β-catenin signaling has been identified as activating microRNA-181s in hepatocellular carcinoma that ... Ji J, Yamashita T, Wang XW (2011). "Wnt/β-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma". ... F9 embryonal carcinoma cells are similar to the P19 cells shown in Figure 1 and normally have cell-to-cell adhesion mediated by ...
Alpha-1 antitrypsin
Rudnick DA, Perlmutter DH (September 2005). "Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in ...
Kansa ya ini, kamusi elezo huru
Hepatocellular carcinoma (HCC): Wagonjwa ambao hupatwa na kansa hii kwa kawaida ni katika idadi ya watu wadogo. Uvimbe huu pia ...
JC virus
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ...
Category:Cancer - Simple English Wikipedia, the free encyclopedia
Hepatocellular carcinoma. *Hodgkin's lymphoma. *Hypopharyngeal cancer. K. *Kaposi's sarcoma. L. *Laryngeal cancer ...
Superoxide dismutase
... including hepatocellular carcinoma,[27] an acceleration of age-related muscle mass loss,[28] an earlier incidence of cataracts ... and inactivation of SOD1 causes hepatocellular carcinoma.[27] Mutations in SOD1 can cause familial ALS (several pieces of ...
Proteasome
Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ...
Mold health issues
"Global Burden of Aflatoxin-Induced Hepatocellular Carcinoma: A Risk Assessment". Environmental Health Perspectives. 118 (6): ...
CD30
It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ ... Hepatocellular carcinoma. *Alpha-fetoprotein/AFP-L3. Reproductive/. urinary/. breast. Ovarian tumor. *Surface epithelial- ...
Cholangiocarcinoma
"Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma". American Journal of Pathology. 134 (6): ... is useful in the diagnosis and may be used to help differentiate a cholangiocarcinoma from hepatocellular carcinoma and ... Roskams T (June 2006). "Liver stem cells and their implication in hepatocellular and cholangiocarcinoma". Oncogene. 25 (27): ... Henson DE, Albores-Saavedra J, Corle D (September 1992). "Carcinoma of the extrahepatic bile ducts. Histologic types, stage of ...
Avihepadnavirus
Diseases associated with this genus include: hepatitis, hepatocellular carcinomas (chronic infections), cirrhosis. Group: ssRNA ...
Hepadnaviridae
Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ...
Necrolytic migratory erythema
Celiac disease Ulcerative colitis Crohn's disease Hepatic cirrhosis Hepatocellular carcinoma Lung cancer, including small cell ... Wilkinson DS (1973). "Necrolytic migratory erythema with carcinoma of the pancreas". Transactions of the St. John's Hospital ...
Carcinoid
malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous hemangioma. * ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ...
Լյարդի քաղցկեղ - Վիքիպեդիա՝ ազատ հանրագիտարան
Tumor markers for hepatocellular carcinoma»։ Mol Clin Oncol 1 (4): 593-598։ 2013։ PMC 3915636։ PMID 24649215։ doi:10.3892/mco. ... Overview of Hepatocellular Carcinoma»։ Liver Cancer։ Արխիվացված օրիգինալից մարտի 18, 2017-ին։ Վերցված է մարտի 18, 2017 ... Management of hepatocellular carcinoma: an update»։ Hepatology 53 (3): 1020-2։ March 2011։ PMC 3084991։ PMID 21374666։ doi: ... 34,0 34,1 34,2 Hoshida Y, Fuchs, BC, Tanabe, KK (Nov 1, 2012)։ «Prevention of hepatocellular carcinoma: potential targets, ...
Evidence-based medicine
... and guidelines for the use of the BCLC staging system for diagnosing and monitoring hepatocellular carcinoma in Canada.[63] ... "Multidisciplinary Canadian Consensus Recommendations for the Management and Treatment of Hepatocellular Carcinoma'". Current ...
Causes of cancer pain
Liver Acute hemorrhage into a hepatocellular carcinoma causes severe upper right quadrant pain, and may be life-threatening, ... most often non-small-cell lung carcinoma (50 percent), small-cell lung carcinoma (25 percent), lymphoma, or metastasis, causing ...
Carcinoma
Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ...
YBX3 - Wicipedia
"DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue. ". Int J Oncol. ... "Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical ...
Cancer
... hepatocellular carcinoma) and human T-cell leukemia virus-1 (T-cell leukemias). Bacterial infection may also increase the risk ... Cancers are usually named using -carcinoma, -sarcoma or -blastoma as a suffix, with the Latin or Greek word for the organ or ... For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... Carcinoma: Cancers derived from epithelial cells. This group includes many of the most common cancers and include nearly all ...
Weight loss
... hepatocellular carcinoma, pancreatic cancer), ovarian, hematologic or lung malignancies. ...
Mir-181 microRNA precursor
It has been shown that conserved miR-181 family were upregulated in EpCAM+ AFP+ Hepatocellular carcinoma (HCC) cells and EpCAM+ ... It was found that miR-181a and miR-181c are overexpressed in Papillary Thyroid Carcinoma tumors, sufficiently to successfully ... Mir-210 has been suggested as a useful biomarker to distinguish adrenocortical carcinoma from adrenocortical adenoma. in ... "The role of microRNA genes in papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United ...
CDH1 (gene)
... enhances Wnt signaling and is over-expressed in hepatocellular carcinoma". Hepatology. 38 (1): 178-86. doi:10.1053/jhep. ... Inactivation of CDH1 (accompany with loss of the wild-type allele) in 56% of lobular breast carcinomas.[54][55] ... Inactivation of CDH1 in 50% of diffuse gastric carcinomas.[56]. *Complete loss of E-cadherin protein expression in 84% of ... Wang HD, Ren J, Zhang L (November 2004). "CDH1 germline mutation in hereditary gastric carcinoma". World Journal of ...
Medical ultrasound
"Advanced Hepatocellular Carcinoma: Early Evaluation of Response to Bevacizumab Therapy at Dynamic Contrast-enhanced US with ... "Hepatocellular carcinoma treated with sorafenib: Early detection of treatment response and major adverse events by contrast- ...
Athari za muda mrefu za pombe, kamusi elezo huru
"Alcohol and hepatocellular carcinoma". Gastroenterology 127 (5 Suppl 1): S87-96. doi:10.1053/j.gastro.2004.09.020 . PMID ... "Alcohol in hepatocellular cancer". Clin Liver Dis 9 (1): 151-69. doi:10.1016/j.cld.2004.10.003 . PMID 15763234 . http:// ...
위키백과:미번역 문서/의학 - 위키백과, 우리 모두의 백과사전
en:Hepatocellular carcinoma (27) → 간세포암 *en:Herpes labialis (25). *en:Hiatal hernia (29) ...
Juvenile polyposis syndrome
malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous hemangioma. * ...
Sirosis bahasa Indonesia, ensiklopedia bebas
Cirrhosis leading to hepatocellular carcinoma (autopsy specimen).. Klasifikasi dan rujukan luar. Spesialisasi. Gastroenterologi ...
SPRED1
... are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors". Oncogene. 25 (45): 6056-66 ...
Radiofrequency ablation
RFA may be combined with locally delivered chemotherapy to treat hepatocellular carcinoma (primary liver cancer). A method ... in Treatment of Hepatocellular Carcinoma (HCC) Hadjicostas, P.; Malakounides, N.; Varianos, C.; Kitiris, E.; Lerni, F.; ... drugs from heat-sensitive liposomes in the margins around the ablated tissue as a treatment for Hepatocellular carcinoma (HCC ...
Hepatocellular Carcinoma | SpringerLink
... characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma ( ... In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide ... Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic ... Measurement of Protein Expression of p53, p21WAF1, and Rb in Patients with Surgically Treated Hepatocellular Carcinoma by Using ...
Hepatocellular carcinoma. - PubMed - NCBI
Hepatocellular Carcinoma --- United States, 2001--2006
... Liver cancer, primarily hepatocellular carcinoma (HCC), is the third ... Decreased incidence of hepatocellular carcinoma in hepatitis B vaccines: a 20-year follow-up study. J Natl Cancer Inst 2009;101 ... Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths in the United States and worldwide; infection with hepatitis ... Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27 ...
Liver Cancer | Hepatocellular Carcinoma | MedlinePlus
The most common form of liver cancer in adults is hepatocellular carcinoma. Learn about diagnosis, treatment and taking part in ... ClinicalTrials.gov: Carcinoma, Hepatocellular (National Institutes of Health) * ClinicalTrials.gov: Hepatoblastoma (National ... Liver (Hepatocellular) Cancer Screening (PDQ)-Patient Version (National Cancer Institute) Also in Spanish ... Risks of Liver (Hepatocellular) Cancer Screening (National Cancer Institute) Also in Spanish ...
Hepatocellular Carcinoma (HCC) (for Parents) - Nemours
Hepatocellular carcinoma (HCC) is a type of liver cancer. Its treated by a health care team of specialists in many areas. ... Carcinoma hepatocelular. What Is Hepatocellular Carcinoma (HCC)?. Hepatocellular carcinoma (HCC) is a type of liver cancer. It ... How Is Hepatocellular Carcinoma (HCC) Diagnosed?. When a child has hepatocellular carcinoma, the doctor will do an exam. Tests ... What Causes Hepatocellular Carcinoma (HCC)?. Doctors dont know the exact cause of hepatocellular carcinoma. Children who have ...
Focus on hepatocellular carcinoma. - PubMed - NCBI
Metastasis in Patients With Hepatocellular Carcinoma
... and prognostic impact of metastasis in hepatocellular carcinoma, proposing a modified BCLC system based on metastasis. ... Extrahepatic metastasis of hepatocellular carcinoma (HCC) is not uncommon. However, its prognostic effect is not fully studied. ... Hepatocellular carcinoma patients with metastasis at the time of diagnosis have shorter overall survival compared to patients ... Re-allocating 181 hepatocellular carcinoma (HCC) patients with a combination of vascular invasion and metastasis from Barcelona ...
External Beam Radiotherapy for Hepatocellular carcinoma
Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. Presented at Liver Disease awareness week 2014 ... External Beam Radiotherapy for Hepatocellular carcinoma * 1. Latest advances in radiotherapy for hepatocellular carcinoma Liver ... Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. Presented at Liver Disease awareness week 2014 ...
Liver Transplantation for Hepatocellular Carcinoma | SpringerLink
... for hepatocellular carcinoma (HCC) in the United States in 1963. In the worlds first 7 LTs, 3 of them were performed for HCC ... Expanded criteria for hepatocellular carcinoma and liver transplantation. Transplant Proc, 2007, 39: 1171-1174.PubMedCrossRef ... Management of hepatocellular carcinoma in the waiting list before liver transplantation. J Hepatol, 2005, 42: S134-S143.PubMed ... Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation, 2008, 85: 1726-1732.PubMedCrossRef ...
What are Hepatocellular Carcinomas?
Hepatocellular carcinoma is the most common type of malignant liver cancer. Primary liver cancers are rare and the condition ... www.hopkinsmedicine.org/.../hepatocellular_carcinoma_liver_cancer.pdf. *www.worldgastroenterology.org/.../24_hepatocellular_ ... What are Hepatocellular Carcinomas?. News-Medical. https://www.news-medical.net/health/What-are-Hepatocellular-Carcinomas.aspx ... Hepatocellular carcinoma is the most common type of malignant liver cancer. Primary liver cancers are rare and the condition ...
Hepatocellular Carcinoma News, Research
Hepatocellular Carcinoma News and Research. RSS Hepatocellular Carcinoma is a type of adenocarcinoma, the most common type of ... Hepatocellular carcinoma is the most common form of liver cancer, and the third biggest cause of death from cancer worldwide. ... Patients with hepatocellular carcinoma (HCC) waiting for a liver transplant in the USA are now significantly less likely to ... New, sensitive HBV assay may allow earlier detection of hepatocellular carcinoma Chronic hepatitis B virus (HBV) can progress ...
Biomarkers for Hepatocellular Carcinoma
... available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was ... The hepatocellular carcinoma (HCC) is one of the most common malignant tumors and carries a poor survival rate. The management ... Biomarkers for Hepatocellular Carcinoma. Tara Behne1 and M. Sitki Copur1. ,. 2. 1College of Pharmacy, University of Nebraska ... Biomarkers for Hepatocellular Carcinoma,. International Journal of Hepatology,. vol. 2012. ,. Article ID 859076. ,. 7. pages. ...
Hepatocellular carcinoma
... (HCC) is the fifth most common cause of cancer, and its incidence is increasing worldwide because of ... Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer, and its incidence is increasing worldwide because of ... Hepatocellular carcinoma Lancet. 2003 Dec 6;362(9399):1907-17. doi: 10.1016/S0140-6736(03)14964-1. ...
FDA approves cabozantinib for hepatocellular carcinoma | FDA
Liver cancer - hepatocellular carcinoma: MedlinePlus Medical Encyclopedia
Hepatocellular carcinoma is cancer that starts in the liver. ... Hepatocellular carcinoma is not the same as metastatic liver ... Hepatocellular carcinoma accounts for most liver cancers. This type of cancer occurs more often in men than women. It is ... To accurately diagnose hepatocellular carcinoma, a biopsy of the tumor must be done. ...
Surveillance for Hepatocellular Carcinoma in Patients With Cirrhosis
Are patients with cirrhosis particularly vulnerable to developing hepatocellular carcinoma, and how should they be screened for ... Journal Article Risk of Hepatocellular Carcinoma in Non-alcoholic Steatohepatitis Without Cirrhosis Compared to Other Liver ... thus meeting the radiographic diagnosis criteria for hepatocellular carcinoma (HCC) of the American Association for the Study ... of Chronic Hepatitis C With Direct-acting Antivirals Does Not Change the Short-term Risk for De Novo Hepatocellular Carcinoma ...
Reptilase test in cirrhosis and hepatocellular carcinoma. | The BMJ
Hepatocellular carcinoma Disease Reference Guide - Drugs.com
Hepatocellular carcinoma (HCC) - Learn about innovative treatment of HCC liver cancer, including liver transplant, ablation and ... Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Hepatocellular carcinoma occurs most often in ... Hepatocellular carcinoma treatments include:. *Surgery. Surgery to remove the cancer and a margin of healthy tissue that ... Which treatment is best for you will depend on the size and location of your hepatocellular carcinoma, how well your liver is ...
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma | Nature
Finally, on the basis of a patient-derived tumour xenograft mouse model of hepatocellular carcinoma, we found that treatment ... Infection with the hepatitis B virus is one of the leading risk factors for developing hepatocellular carcinoma, particularly ... Our quantitative proteomic data highlight heterogeneity in early-stage hepatocellular carcinoma: we used this to stratify the ... The proteomic stratification of early-stage hepatocellular carcinoma presented in this study provides insight into the tumour ...
Hepatocellular carcinoma Archives - Vanguard News
Hepatocellular Carcinoma (HCC) Symptoms & Treatment
Learn more about hepatocellular carcinoma, including its symptoms, risks, and treatment options. ... Diagnosing Hepatocellular Carcinoma. Symptoms of hepatocellular carcinoma. Many people with hepatocellular carcinoma (HCC) have ... Hepatocellular Carcinoma Overview. Hepatocellular carcinomas (HCC) are also known as primary liver cancers, hepatic tumors, or ... Testing for hepatocellular carcinoma. In addition to a physical exam, your doctor may order the following tests to help ...
Hepatocellular Carcinoma Blogs
Hepatocellular carcinoma (HCC) with a focus on diagnosis and screening. (Source: Notes from Dr. RW). Source: Notes from Dr. RW ... Rapid Hepatocellular Carcinoma Test Can be Administered Anywhere. Researchers at the University of Utah have developed a rapid ... Hepatocellular Carcinoma Blogs This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to ... Hepatocellular Carcinoma : Triple Phase CT. Presenting brief teaching video under the DAMS Unplugged series on HCC and imaging ...
FDA grants accelerated approval to pembrolizumab for hepatocellular carcinoma | FDA
... for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. ... Adverse reactions occurring in patients with hepatocellular carcinoma were similar to those described in KEYTRUDA product ... The recommended pembrolizumab dose for hepatocellular carcinoma is 200 mg administered as an intravenous infusion over 30 ... for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. ...
Hepatocellular carcinoma - definition of hepatocellular carcinoma by The Free Dictionary
hepatocellular carcinoma synonyms, hepatocellular carcinoma pronunciation, hepatocellular carcinoma translation, English ... Noun 1. hepatocellular carcinoma - carcinoma of the liver hepatocarcinoma, hepatoma, malignant hepatoma carcinoma - any ... hepatocellular carcinoma - carcinoma of the liver hepatocarcinoma, hepatoma, malignant hepatoma. carcinoma - any malignant ... Hepatocellular Carcinoma - Pipeline Review, H1 2016, provides an overview of the Hepatocellular Carcinoma pipeline landscape. ...
Combination Therapy Improves Hepatocellular Carcinoma Survival | Medpage Today
For large hepatocellular carcinoma tumors, transarterial chemoembolization plus radiofrequency ablation improves survival ... Blood flow to hepatocellular carcinoma lesions can be substantially reduced by the arterial embolization effect of ... The 291 consecutive patients with hepatocellular carcinoma larger than 3 cm were randomly assigned to treatment with an ... In particular, neither results in adequate control of hepatocellular carcinoma tumors larger than 3 cm." ...
New Insights into the Epigenetics of Hepatocellular Carcinoma
... miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma ... microvascular invasion in hepatocellular carcinoma promotes angiogenesis and serves as a predictor for hepatocellular carcinoma ... "H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and ... New Insights into the Epigenetics of Hepatocellular Carcinoma. Braira Wahid,1 Amjad Ali,1 Shazia Rafique,1 and Muhammad Idrees1 ...
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals | Scientific Reports
... represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C , T ... Table 5 Independent predictors of hepatocellular carcinoma (HCC) in 1121 non-cirrhotic patients with chronic liver diseases ... Risk of hepatocellular carcinoma according to the number of PNPLA3 I148M, TM6SF2 E167K, and MBOAT7 rs641738 C , T risk variants ... Table 2 Frequency distribution of PNPLA3, TM6SF2, and MBOAT7 variants according to hepatocellular carcinoma (HCC) in 765 ...
Liver Cell Adenoma or Hepatocellular Carcinoma?
Hepatocellular carcinoma: epidemiology and risk factors
The number of new cases of the tumor increases year by year, and hepatocellular carcinoma almost always runs a fulminant course ... Hepatocellular carcinoma is one of the major malignant tumors in the world today. ... Hepatocellular carcinoma: epidemiology and risk factors J Hepatocell Carcinoma. 2014 Aug 13;1:115-25. doi: 10.2147/JHC.S44381. ... Hepatocellular carcinoma is one of the major malignant tumors in the world today. The number of new cases of the tumor ...
Management of Hepatocellular Carcinoma: Updated Review
Hepatocellular carcinoma (HCC) represents one of the most challenging potentially curable tumors with high incidence, ... "Management of Hepatocellular Carcinoma: Updated Review" written by Tamer Elbaz, Mohamed El Kassas, Gamal Esmat, published by ... score can predict survival after hepatocellular carcinoma treatment in a cohort of 1302 Egyptian hepatocellular carcinoma ... score can predict survival after hepatocellular carcinoma treatment in a cohort of 1302 Egyptian hepatocellular carcinoma ...
Cause of hepatocellular carcinomaTumorTherapy for hepatocellular carcinomaDiagnosisLarge hepatocellular carcinomaUnresectable hepatocellular carcinomaPrognosisClinicalChemoembolizationPatients with cirrhosisTreat hepatocellularEarly detection of hepatocellular carcinomaTransarterialOptions for treating hepatocellular2016Field of hepatocellular carcinomaPeople with hepatocellular carcinomaCriteria for hepatocellular carcinomaCirrhosis and hepatocellular carcinomaDevelopment of hepatocellular carcinomaRadiotherapy2018HepatomaTumorsCauses Hepatocellular CarcinomaConventional hepatocellular carcinomaManagement of hepatocellularSurvivalEfficacyBiopsyFibrolamellar hepatocelHepatitis B virus infectiCancerTherapeuticTreatmentInfection2019BiomarkersChronic liver dSymptomsPrimaryResectionMetastasis
Cause of hepatocellular carcinoma7
- Doctors don't know the exact cause of hepatocellular carcinoma. (kidshealth.org)
- Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. (nature.com)
- Chronic hepatitis C virus infection is an important cause of hepatocellular carcinoma in resource-rich countries with a low incidence of the tumor. (nih.gov)
- In recent years, obesity and the metabolic syndrome have increased markedly in incidence and importance as a cause of hepatocellular carcinoma in some resource-rich regions. (nih.gov)
- Geographically, the global Hepatocellular Carcinoma (HCC) treatment market is classified into regions namely, North America, Latin America, Western Europe, Eastern Europe, APEJ, Japan, Middle East and Africa.Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infections are found to be the most significant cause of hepatocellular carcinoma. (openpr.com)
- Chronic HBV infection is the principal cause of hepatocellular carcinoma in Asia and Africa. (openpr.com)
- HCV infection is the principal cause of hepatocellular carcinoma in North America, Europe, and Japan. (openpr.com)
Tumor20
- This year the number of papers published regarding hepatocellular carcinoma (HCC) continued to increase compared with last year, coinciding with an increase in incidence and awareness of this tumor. (nih.gov)
- Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. (springer.com)
- Tumor size predicts vascular invasion and histologic grade: implications for selection of surgical treatment for hepatocellular carcinoma. (springer.com)
- Orthotopic liver transplantation for patients with hepatocellular carcinoma complicated by portal vein tumor thrombi. (springer.com)
- Preoperative human-telomerase reverse transcriptase mRNA in peripheral blood and tumor recurrence in living-related liver transplantation for hepatocellular carcinoma. (springer.com)
- Hepatocellular carcinoma (HCC) is one such cancer that can benefit from tumor biomarkers' diagnostic, therapeutic, and prognostic capabilities. (hindawi.com)
- The first serologic assay for detection and clinical followup of patients with hepatocellular carcinoma was alpha-fetoprotein (AFP) which has been the standard tumor biomarker for HCC for many years. (hindawi.com)
- To accurately diagnose hepatocellular carcinoma, a biopsy of the tumor must be done. (medlineplus.gov)
- TriSalus, a Denver, Colorado firm, is launching a new solid tumor infusion system to target hepatocellular carcinoma, liver metastases, and other tumors. (medworm.com)
- The number of new cases of the tumor increases year by year, and hepatocellular carcinoma almost always runs a fulminant course and carries an especially grave prognosis. (nih.gov)
- The most common risk factors for hepatocellular carcinoma in resource-poor populations with a high incidence of the tumor are chronic hepatitis B virus infection and dietary exposure to the fungal hepatocarcinogen aflatoxin B1. (nih.gov)
- Here, we adopted a mouse model and metagenome sequencing to investigate the efficacy of probiotic feeding in controlling s.c. hepatocellular carcinoma (HCC) and the underlying mechanism suppressing the tumor progression. (pnas.org)
- Hepatocellular carcinoma (HCC) is the most common primary liver tumor and results in approximately 700,000 deaths annually worldwide. (rarediseases.org)
- AMA J Dis Child 91(2):168-186 Craig JR, Peters RL, Edmondson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. (wikipedia.org)
- Children with hepatocellular carcinoma are treated in the Liver Tumor Center at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center. (childrenshospital.org)
- Hepatocellular carcinoma describes a rare but malignant tumor of the epithelial tissues of the liver (the tissue that lines the cavities and surfaces of body structures - in this case the liver). (petmd.com)
- This type of tumor is rare in cats - cats are more commonly affected by bile duct carcinoma. (petmd.com)
- Hepatocellular carcinoma (HCC) is a typical hypervascularized tumor, and the predictive value of MVD for prognosis is still controversial. (frontiersin.org)
- MVD in multinodular hepatocellular carcinoma represents a subject area with huge understudied potential, and exploring it might advance our understanding of tumor heterogeneity. (frontiersin.org)
- Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and the third most common cause of cancer-related death worldwide. (renalandurologynews.com)
Therapy for hepatocellular carcinoma2
- We have pursued laparoscopic hepatectomy as a means of surgical therapy for hepatocellular carcinoma (HCC) since 1993. (sages.org)
- Currently, sorafenib and lenvatinib, two multi-kinase inhibitors with potent anti-angiogenic capacity, are first-line therapy for hepatocellular carcinoma (HCC) that accounts for 80% of primary liver cancer ( 6 , 7 ). (frontiersin.org)
Diagnosis6
- A subsequent triphasic abdominal computed tomography (CT) scan showed a 2.2-cm well-circumscribed vascular mass that had arterial enhancement and venous washout, thus meeting the radiographic diagnosis criteria for hepatocellular carcinoma (HCC) of the American Association for the Study of Liver Disease (AASLD). (medscape.com)
- Objective: To determine the diagnostic accuracy of quantitative washout calculated on Triphasic CT scan for diagnosis of hepatocellular carcinoma keeping histopathology as gold standard. (thefreedictionary.com)
- The diagnosis of hepatocellular carcinoma (HCC) in lobectomy specimens is usually straightforward, but distinguishing cirrhosis from well-differentiated HCC can be challenging in core biopsies. (thefreedictionary.com)
- Presenting the most up-to-date knowledge of hepatocellular carcinoma, it covers all topics - including those more controversial ones - in this rapidly advancing field, from epidemiology to prevention, from molecular biology to gross pathology, from screening to atypical presentation, from diagnosis to treatment, and from assessment to choice of appropriate treatment. (ovid.com)
- Conventionally, the diagnosis of hepatocellular carcinoma (HCC) is performed by qualitative examination of histopathological specimens, which takes times for sample preparation in fixation, section and stain. (mit.edu)
- This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. (exlibris.ch)
Large hepatocellular carcinoma2
- JINAN, China, April 8 -- For large hepatocellular carcinoma tumors, transarterial chemoembolization plus radiofrequency ablation improves survival better than either alone, according to researchers here. (medpagetoday.com)
- Is resection for large hepatocellular carcinoma in cirrhotic patients beneficial? (nii.ac.jp)
Unresectable hepatocellular carcinoma8
- announced today that the results of an analysis of a Phase III trial (REFLECT study / Study 304)1 of its in-house discovered and developed anticancer agent lenvatinib mesylate (product names: Lenvima / Kisplyx, lenvatinib) versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma based on independent imaging review were presented2 during the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO-GI) 2018, in San Francisco, the United States. (thefreedictionary.com)
- The exact role for transarterial chemoembolization-radiofrequency ablation in the treatment of patients with unresectable hepatocellular carcinoma remains a controversial and unresolved issue," they wrote, "similar to the situation for many of the interventional-based therapies. (medpagetoday.com)
- To assess the benefits and harms of immune checkpoint inhibitors versus placebo, no treatment, or other systemic or locoregional therapies for people with unresectable hepatocellular carcinoma. (cochrane.org)
- Abdel-Rahman O, Elsayed Z. Immune checkpoint inhibitors for unresectable hepatocellular carcinoma. (cochrane.org)
- Officials with the FDA have approved lenvatinib capsules (Lenvima, Eisai Inc.) for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). (pharmacytimes.com)
- FDA approves lenvatinib for unresectable hepatocellular carcinoma [news release]. (pharmacytimes.com)
- Woodcliff Lake, NJ and Kenilworth, NJ, Aug. 16, 2018 - Eisai Inc. and Merck (NYSE: MRK), known as MSD outside of the United States and Canada, announced today that the U.S. Food and Drug Administration (FDA) approved the kinase inhibitor Lenvima ( lenvatinib ) for the first-line treatment of patients with unresectable hepatocellular carcinoma ( HCC ). (drugs.com)
- Unresectable hepatocellular carcinoma is an extremely difficult-to-treat cancer, with no new first-line systemic therapy options for more than a decade," said Dr. Ghassan Abou-Alfa, medical oncologist, Memorial Sloan Kettering Cancer Center. (drugs.com)
Prognosis5
- Role of Pittsburgh modified TNM criteria in prognosis prediction of liver transplantation for hepatocellular carcinoma. (springer.com)
- The present invention provides a method for predicting prognosis of hepatocellular carcinoma patients based on measurement of the relative level of expression of a combination of 15 immune genes of interest, or a subset thereof, in the tumors of such patients. (freepatentsonline.com)
- By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC. (exlibris.ch)
- Although sorafenib enhances overall survival, sorafenib resistance has been reported to be a significant limiting factor for improved prognosis in patients with hepatocellular carcinoma (HCC). (bioportfolio.com)
- Hepatocellular carcinoma (HCC) is an aggressive malignancy with a poor prognosis. (atlasgeneticsoncology.org)
Clinical12
- In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. (springer.com)
- Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma. (springer.com)
- Can-Fite BioPharma Ltd., a biotechnology company advancing a pipeline of proprietary small molecule drugs that address cancer, liver and inflammatory diseases, today provided an update on its Phase II clinical trial with drug candidate Namodenoson in the treatment of advanced hepatocellular carcinoma in patients whose disease has progressed on sorafenib therapy. (news-medical.net)
- Here, using proteomic and phospho-proteomic profiling, we characterize 110 paired tumour and non-tumour tissues of clinical early-stage hepatocellular carcinoma related to hepatitis B virus infection. (nature.com)
- Our quantitative proteomic data highlight heterogeneity in early-stage hepatocellular carcinoma: we used this to stratify the cohort into the subtypes S-I, S-II and S-III, each of which has a different clinical outcome. (nature.com)
- Lafaro KJ, Pawlik TM (2015) Fibrolamellar hepatocellular carcinoma: current clinical perspectives. (wikipedia.org)
- As Clinical Markers, Hand-Foot-Skin Reaction and Diarrhea Can Predict Better Outcomes for Hepatocellular Carcinoma Patients Receiving Transarterial Chemoembolization plus Sorafenib. (medworm.com)
- Respiratory-gated, volumetric-modulated arc therapy will be used for the clinical development of high dose rate Stereotactic Body Radiotherapy (SBRT) in inoperable hepatocellular carcinoma (HCC). (clinicaltrials.gov)
- Boston, MA -- ( SBWIRE ) -- 04/30/2014 -- GlobalData's clinical trial report, "Metastatic Hepatocellular Carcinoma (HCC) Global Clinical Trials Review, H1, 2014" provides data on the Metastatic Hepatocellular Carcinoma (HCC) clinical trial scenario. (sbwire.com)
- This report provides elemental information and data relating to the clinical trials on Metastatic Hepatocellular Carcinoma (HCC). (sbwire.com)
- The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Metastatic Hepatocellular Carcinoma (HCC). (sbwire.com)
- This review covers the general aspects of gene therapy vectors, preclinical data available in animal models of hepatocellular carcinoma, and finally a brief summary of the gene therapy clinical trials aimed at the treatment of liver cancer. (cun.es)
Chemoembolization1
- Blood flow to hepatocellular carcinoma lesions can be substantially reduced by the arterial embolization effect of transcatheter arterial chemoembolization treatment. (medpagetoday.com)
Patients with cirrhosis2
- Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. (springer.com)
- Regardless of etiology, all patients with cirrhosis are at risk for hepatocellular carcinoma (HCC). (healio.com)
Treat hepatocellular2
- Doctors usually treat hepatocellular carcinoma with a combination of surgery and chemotherapy . (kidshealth.org)
- If diagnosed at an early stage, it may be possible to treat hepatocellular carcinoma. (news-medical.net)
Early detection of hepatocellular carcinoma1
- The technological advancements and the routine liver function tests are now resulting in the early detection of hepatocellular carcinoma. (openpr.com)
Transarterial1
- A retrospective review published in the American Journal of Roentgenology (AJR) has found that aspirin therapy is associated with both improved liver function test results and survival after transarterial embolization (TAE) for hepatocellular carcinoma (HCC). (pharmacytimes.com)
Options for treating hepatocellular1
- At NorthShore, we offer a full complement of leading-edge options for treating hepatocellular carcinoma. (northshore.org)
20161
- 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602671/5/Hepatocellular_Carcinoma. (unboundmedicine.com)
Field of hepatocellular carcinoma2
- This volume is therefore an important contribution to the field of hepatocellular carcinoma. (ovid.com)
- A panel of international oncology experts recently met to exchange thoughts on developments in the field of hepatocellular carcinoma (HCC), the most common form of liver cancer. (curetoday.com)
People with hepatocellular carcinoma3
- Many people with hepatocellular carcinoma (HCC) have no symptoms until the disease becomes advanced. (upmc.com)
- The UPMC Liver Cancer Center's multidisciplinary team of experts offers several treatment options for people with hepatocellular carcinoma (HCC). (upmc.com)
- Approximately 3 to 5 percent of the population with cirrhosis is diagnosed with hepatocellular carcinoma each year, and about 80 percent of all people with hepatocellular carcinoma are cirrhotic. (microscopyu.com)
Criteria for hepatocellular carcinoma2
- Liver transplantation criteria for hepatocellular carcinoma should be expanded: a 22-year experience with 467 patients at UCLA. (springer.com)
- Expanded criteria for hepatocellular carcinoma and liver transplantation. (springer.com)
Cirrhosis and hepatocellular carcinoma2
Development of hepatocellular carcinoma2
- The development of hepatocellular carcinoma can disrupt these functions or even cause them to fail altogether. (news-medical.net)
- A research team led by scientists from the Cancer Institute of Singapore at the National University of Singapore has developed a novel peptide drug called FFW that could potentially stop the development of hepatocellular carcinoma or primary liver cancer. (news-medical.net)
Radiotherapy2
- Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. (slideshare.net)
- Radiotherapy is not considered standard of care practice for patients for inoperable hepatocellular carcinoma despite the tumour's inherent radiosensitivity. (clinicaltrials.gov)
20181
- On November 9, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA, Merck & Co., Inc.) for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. (fda.gov)
Hepatoma3
- Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. (medindia.net)
- Hepatocellular carcinoma (HCC) is also known as malignant hepatoma. (openpr.com)
- Primary hepatocellular carcinoma (HCC), sometimes called hepatoma, is the most common form of primary liver malignancy 1 and is among the 10 most common tumours 2 in the world. (bmj.com)
Tumors7
- The hepatocellular carcinoma (HCC) is one of the most common malignant tumors and carries a poor survival rate. (hindawi.com)
- Hepatocellular carcinomas (HCC) are also known as primary liver cancers , hepatic tumors , or hepatomas . (upmc.com)
- In particular, neither results in adequate control of hepatocellular carcinoma tumors larger than 3 cm. (medpagetoday.com)
- Hepatocellular carcinoma is one of the major malignant tumors in the world today. (nih.gov)
- The infection is acquired in adulthood and hepatocellular carcinoma occurs later than it does with hepatitis B virus-induced tumors. (nih.gov)
- Certain benign liver tumors, such as hepatocellular adenoma, may sometimes be associated with coexisting malignant HCC. (wikipedia.org)
- Carcinomas are malignant tumors found both in humans and animals. (petmd.com)
Causes Hepatocellular Carcinoma2
- What Causes Hepatocellular Carcinoma (HCC)? (kidshealth.org)
- What causes hepatocellular carcinoma in children? (childrenshospital.org)
Conventional hepatocellular carcinoma3
- FHCC often does not produce alpha fetoprotein (AFP), a widely used marker for conventional hepatocellular carcinoma. (wikipedia.org)
- Conventional hepatocellular carcinoma is more frequently diagnosed in adults and is often seen in conjunction with underlying liver disease (for example, cirrhosis ). (childrenshospital.org)
- Fibrolamellar hepatocellular carcinoma is a unique, rare entity apart from conventional hepatocellular carcinoma and requires novel and experienced approaches to care. (childrenshospital.org)
Management of hepatocellular3
- Management of hepatocellular carcinoma in the waiting list before liver transplantation. (springer.com)
- Management of hepatocellular carcinoma (HCC) is best performed in a multidisciplinary setting. (medscape.com)
- Another option is gene therapy, which although in its infancy at the present time, may have a significant role to play in the future management of hepatocellular carcinoma. (bmj.com)
Survival2
- Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. (springer.com)
- The purpose of the study was to evaluate the efficacy of enzalutamide in participants with advanced hepatocellular carcinoma (HCC) as measured by overall survival (OS). (pfizer.com)
Efficacy1
- Efficacy of annexin A3 blockade in sensitizing hepatocellular carcinoma to sorafenib and regorafenib. (bioportfolio.com)
Biopsy1
- 60 patients of radiological, biopsy proven advanced HCC (Hepatocellular carcinoma) patient will be randomized into two groups. (bioportfolio.com)
Fibrolamellar hepatocel2
- Fibrolamellar hepatocellular carcinoma (FHCC) is a rare form of hepatocellular carcinoma (HCC) that typically affects young adults and is characterized, under the microscope, by laminated fibrous layers interspersed between the tumour cells. (wikipedia.org)
- The name fibrolamellar hepatocellular carcinoma was coined by Craig et al. (wikipedia.org)
Hepatitis B virus infecti1
- Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, and its incidence is increasing in different populations in recent decades, specifically in Asian countries due to hepatitis B virus infection. (frontiersin.org)
Cancer33
- Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. (springer.com)
- Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading cause of death from cancer worldwide and the ninth leading cause of cancer deaths in the United States ( 1,2 ). (cdc.gov)
- Hepatocellular carcinoma (HCC) is a type of liver cancer . (kidshealth.org)
- Hepatocellular carcinoma is the most common type of malignant liver cancer. (news-medical.net)
- My son was diagnosed with Hepatocellular-Carcinoma ( Liver cancer) when he was 15 and he has almost made his way to the 5 year mark, I worry about him everyday and hope he is in the clear! (news-medical.net)
- Hepatocellular carcinoma is the most common form of liver cancer, and the third biggest cause of death from cancer worldwide. (news-medical.net)
- Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer, and its incidence is increasing worldwide because of the dissemination of hepatitis B and C virus infection. (nih.gov)
- Hepatocellular carcinoma is cancer that starts in the liver. (medlineplus.gov)
- Hepatocellular carcinoma is not the same as metastatic liver cancer , which starts in another organ (such as the breast or colon) and spreads to the liver. (medlineplus.gov)
- Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide. (nature.com)
- The proteomic stratification of early-stage hepatocellular carcinoma presented in this study provides insight into the tumour biology of this cancer, and suggests opportunities for personalized therapies that target it. (nature.com)
- It was reported on Friday that the contract has been signed to develop RX-0201 (Archexin) intended for the treatment of hepatocellular carcinoma , the most common form of liver cancer. (thefreedictionary.com)
- Merck announced findings from the registrational phase 2 KEYNOTE-224 trial investigating the use of KEYTRUDA, the company's anti-PD-1 therapy, in patients with advanced hepatocellular carcinoma , the most common type of liver cancer, who were previously treated with systemic therapy. (thefreedictionary.com)
- Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (wikipedia.org)
- Hepatocellular carcinoma is the second most deadly cancer type globally, requiring the development of alternative or complementary therapeutic and prophylactic methods. (pnas.org)
- The global hepatocellular carcinoma treatment market is expected to grow in future due to increasing investment by multinational companies in the cancer research. (openpr.com)
- Hepatocellular carcinoma , also called liver carcinoma, is a rare, aggressive type of liver cancer. (childrenshospital.org)
- Primary liver cancer (hepatocellular carcinoma) is the fifth most common cause of cancer death in American men and the ninth most common cause of death in women. (northshore.org)
- Alcohol-related cirrhosis and chronic hepatitis B or C infection contribute to the majority of liver cancer cases diagnosed in the U.S. Obesity and diabetes are also major factors in the rise of hepatocellular carcinoma. (northshore.org)
- Treating hepatocellular carcinoma (HCC), the most common form of liver cancer, is exceptionally challenging today. (curetoday.com)
- Hepatocellular carcinoma is the fifth most common [cancer] worldwide," said panelist Amit Singal, M.D., M.S. He said the highest rates of HCC are in East Asia and Africa, where the primary driver is hepatitis B virus (HBV). (curetoday.com)
- Hepatocellular carcinoma (HCC) is the most common primary liver cancer and accounts for about 6% of all new cancer cases worldwide. (europa.eu)
- The current treatment guidelines of hepatocellular carcinoma (HCC) of the American and European Associations for the Study of Liver Disease are based on the Barcelona-Clinic-Liver-Cancer classification (BCLC), which does not recommend surgery in patients with large, multinodular and macrovascular invasive disease. (clinicaltrials.gov)
- Hepatocellular carcinoma is a form of cancer that originates in hepatocytes. (microscopyu.com)
- In the United States, hepatocellular carcinoma is relatively rare, but globally it is one of the leading causes of cancer-related death. (microscopyu.com)
- Andrew Zhu, the lead trial investigator and head of liver cancer research at Massachusetts General Hospital , said hepatocellular carcinoma is the most common type of liver cancer in adults. (biospace.com)
- We look forward to continuing to advance research for hepatocellular carcinoma across our portfolio with the goal to help even more patients affected by this type of cancer," Ebbinghaus said in a statement. (biospace.com)
- Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. (genome.jp)
- FDA approved treatment for Advanced Hepatocellular cancer. (bioportfolio.com)
- Hepatocellular carcinoma (HCC) is a highly invasive cancer associated with high mortality rates. (bioportfolio.com)
- Hepatocellular carcinoma (HCC) is the leading threat of cancer-related death in humans. (doaj.org)
- Dana-Farber/Brigham and Women's Cancer Center includes some of the world's top researchers and clinicians in hepatocellular carcinoma, the most common type of primary liver cancer. (dana-farber.org)
- Hepatocellular Carcinoma (HCC) is worldwide the fifth most common cancer in men and represents the third most frequent cause of cancer death. (omicsonline.org)
Therapeutic1
- In addition, we found that variants within several drug targets such as KIT, SYK, and PIK3CA were mutated in a fully clonal manner, indicating their therapeutic potentials for hepatocellular carcinoma. (aacrjournals.org)
Treatment20
- Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients. (springer.com)
- Which treatment is best for you will depend on the size and location of your hepatocellular carcinoma, how well your liver is functioning, and your overall health. (drugs.com)
- Finally, on the basis of a patient-derived tumour xenograft mouse model of hepatocellular carcinoma, we found that treatment with avasimibe, an inhibitor of SOAT1, markedly reduced the size of tumours that had high levels of SOAT1 expression. (nature.com)
- The 291 consecutive patients with hepatocellular carcinoma larger than 3 cm were randomly assigned to treatment with an emulsion of 50 mg of cisplatin (Platinol) and 10 mL of lipiodol (Lipiocis) followed by embolization with granules of gelatin sponge particles, with RF ablation at a temperature of 100 C, or with both. (medpagetoday.com)
- The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (wikipedia.org)
- The increase in incidences of hepatocellular carcinoma associated with hepatitis C virus are expected to grow the hepatocellular carcinoma treatment market during the forecast period. (openpr.com)
- The advancement in technology, personalized medicine, cost effective treatment procedures are few other factors predicted to keep up the growth of global hepatocellular carcinoma treatment market. (openpr.com)
- However, side effects associated with the chemotherapy, high cost of treatment are some of the major restraints limiting the growth of global hepatocellular carcinoma treatment market. (openpr.com)
- The global hepatocellular carcinoma (HCC) treatment market has been segmented on the basis of application, end use and geography. (openpr.com)
- Moreover, the increasing investment of pharmaceutical companies in the research and development of anticancer drugs would contribute to the growth of hepatocellular carcinoma treatment market. (openpr.com)
- Bayer AG is one of the leading provider of hepatocellular carcinoma (HCC) treatment drugs. (openpr.com)
- Some of the key players in hepatocellular carcinoma treatment market are Novartis Pharmaceuticals, Merck & Co., Inc., Bristol-Myers Squibb Company, AbbVie Inc., Johnson & Johnson Pvt. (openpr.com)
- See also Hepatocellular Carcinoma Treatment Protocols . (medscape.com)
- On Friday, the FDA approved Keytruda, an anti-PD-1 therapy, for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with the chemotherapy drug sorafenib. (biospace.com)
- Zhu said the latest approval of Keytruda is important as it "provides a new treatment option for patients with hepatocellular carcinoma who have been previously treated with sorafenib. (biospace.com)
- Sorafenib is a standard treatment for Hepatocellular Carcinoma. (bioportfolio.com)
- The purpose of the study is to determine whether 4SC-201 alone or in combination with Sorafenib is effective and safe in the treatment of hepatocellular carcinoma in patients refractory to. (bioportfolio.com)
- Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. (bioportfolio.com)
- The extraordinary versatility of gene therapy opens new possibilities for the treatment of incurable diseases, including hepatocellular carcinoma. (cun.es)
- When it comes to hepatocellular carcinoma (HCC), doctors have a handful of treatment options at their disposal. (curetoday.com)
Infection3
- Hepatocellular carcinoma occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection. (drugs.com)
- The risk factors associated with hepatocellular carcinoma are Hepatitis B virus (HBV) infection and hepatitis C virus (HCV) infection, alcoholic cirrhosis, metabolic syndrome, biliary cirrhosis, and chronic liver injury. (openpr.com)
- When diagnosed in children, hepatocellular carcinoma may be linked to hepatitis infection or genetic conditions. (childrenshospital.org)
20193
- Retrieved on June 25, 2019 from https://www.news-medical.net/health/What-are-Hepatocellular-Carcinomas.aspx. (news-medical.net)
- 2019. What are Hepatocellular Carcinomas? . (news-medical.net)
- On January 14, 2019, the Food and Drug Administration approved cabozantinib (CABOMETYX, Exelixis, Inc.) for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. (fda.gov)
Biomarkers2
- In this paper, a summary of most relevant available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was presented. (hindawi.com)
- Understanding the intratumoral heterogeneity of hepatocellular carcinoma is instructive for developing personalized therapy and identifying molecular biomarkers. (aacrjournals.org)
Chronic liver d3
- An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. (bioportfolio.com)
- An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. (ingentaconnect.com)
- US-born Hispanics are more likely to get hepatocellular carcinoma and to die from chronic liver disease compared with their foreign-born counterparts. (cancernetwork.com)
Symptoms1
- What Are the Signs & Symptoms of Hepatocellular Carcinoma (HCC)? (kidshealth.org)
Primary1
- Primary hepatocellular carcinoma is one of the 10 most common tumours, and the most common primary liver malignancy, in the world. (bmj.com)
Resection2
- We present a patient with a 15 year history of genetic haemachromatosis who underwent resection of a hepatocellular carcinoma in a liver with normal architecture. (hindawi.com)
- Liver resection for hepatocellular carcinoma. (nii.ac.jp)
Metastasis2
- Association between hepatocellular carcinoma (HCC)-related variables and metastasis stratified by total tumour volume (TTV). (medscape.com)
- Hepatocellular carcinoma (HCC), hypervascular metastasis and hepatic adenoma. (appliedradiology.com)