Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
A scraping, usually of the interior of a cavity or tract, for removal of new growth or other abnormal tissue, or to obtain material for tissue diagnosis. It is performed with a curet (curette), a spoon-shaped instrument designed for that purpose. (From Stedman, 25th ed & Dorland, 27th ed)
Tumors or cancer located in bone tissue or specific BONES.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Chronic inflammation and granuloma formation around irritating foreign bodies.
A malignant epithelial tumor with a glandular organization.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the LUNG.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
Tumors or cancer of the THYROID GLAND.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tumors or cancer of the human BREAST.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tumors or cancer of the ESOPHAGUS.
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Tumors or cancer of the SKIN.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A superorder of CEPHALOPODS comprised of squid, cuttlefish, and their relatives. Their distinguishing feature is the modification of their fourth pair of arms into tentacles, resulting in 10 limbs.
Elements of limited time intervals, contributing to particular results or situations.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
DNA present in neoplastic tissue.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Tumors or cancer of the UTERINE CERVIX.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Antibodies produced by a single clone of cells.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Tumors or cancer of the MANDIBLE.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A superfamily of nematodes whose members are free-living saprophytes or parasites of plants. Ova are sometimes found in human feces after ingestion of infected plants.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Outgrowths of synovial membrane composed of villi and fibrous nodules characterized histologically by hemosiderin- and lipid-containing macrophages and multinucleated giant cells. It usually occurs in the knee.
RNA present in neoplastic tissue.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
Transplantation between animals of different species.
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Measurement of rate of settling of erythrocytes in anticoagulated blood.
Tumors or cancer of the BRONCHI.
The grafting of bone from a donor site to a recipient site.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Established cell cultures that have the potential to propagate indefinitely.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Neoplasms of the bony part of the skull.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Study on the metastatic mechanisms of human giant-cell lung carcinoma comparison between the strains C and D. (1/25)

The biologic characteristics of the two human giant-cell lung carcinoma strains with high (strain D) and low metastatic potential (strain C) were studied, including karyotype of chromosome, intracellular free calcium ([Ca2+]i), morphologic changes of cell surface and the expression of nm23-H1, p53, ras, c-myc, c-erbB2, bcl-2 genes and PCNA. The correlation between different biologic features and the metastatic potential of the two strains was analyzed. We found: 1) Both strains had the karyotypic abnormality of -13, -14, -15, +20, +21 with seven same marker chromosomes. Only strain D had the karyotypic abnormality of +7, -17, -18, +X, 7p+; 2) [Ca2+]i of the strain C (984.7 +/- 573.8) and D (517.6 +/- 216.6) was significantly different (p < 0.05). The amplitude of intracellular calcium oscillations of strain C was lower than the one of strain D; 3) strain C had more villous-like protrusions on the cell surface, whereas strain D had more bubble-like protrusions; 4) The expression of nm23-H1 and p53 protein of strain C was all higher than that of strain D. The expression of PCNA of strain C was lower than strain D; 5) nm23-H1 mRNA levels of strain C was lower than that of strain D. We consider that the karyotype of chromosomes, intracellular free calcium, the structure of cell membrane and the expression of nm23-H1 gene, p53 gene, PCNA could be closely related to the metastatic potential of human giant-cell lung carcinoma. They could be used as the sign for judging whether the tumor will metastasize in clinical practice as well as in judging the prognoses of patients.  (+info)

Effect of interleukin-6 on the growth of human lung cancer cell line. (2/25)

OBJECTIVE: To investigate the effect of interleukin-6 (IL-6) on the growth of human lung cancer in vivo as well as in vitro. METHODS: To examine the mRNA level of IL-6 receptor (IL-6R) in high-metastatic human lung giant cell carcinoma cell line PG by means of reverse transcription polymerase chain reaction (RT-PCR). To assess the existence of IL-6 receptor complex (including IL-6R and gp130) with the treatment of PG cells by use of recombinant human IL-6 (rhIL-6), recombinant human oncostatin M (rhOSM), and recombinant human leukemia inhibitory factor (rhLIF), respectively. To detect the expression of IL-6 by Northern blotting hybridization and bioactive assay. To identify the effect of IL-6 secreted by PG cells by use of IL-6 and IL-6R antisense oligodeoxynucleotides (ODNs), and specific neutralizing antibody to IL-6. To document the influence of IL-6 on PG cells growth in vivo through the strategy of the transfection of expression vector inserted antisense IL-6 cDNA. RESULTS: RT-PCR analysis revealed that PG cells expressed IL-6R mRNA. Any one of the recombinant cytokine IL-6, OSM and LIF stimulated the growth of PG cells in vitro in a concentration-dependent manner. These results demonstrated IL-6 receptor complex exist in PG cells. At the same time, PG cells expressed IL-6 mRNA and secreted bioactive IL-6. Both IL-6 antisense ODNs and IL-6R ODNs inhibited PG cells proliferation. Treatment of PG cells with IL-6 antibodies reduced the growth of PG cells in vitro. PG cells transfected with IL-6 antisense expression vector showed a decreased growth in nude mice. CONCLUSION: IL-6 functions as an autocrine growth stimulator for PG cells in vivo as well as in vitro.  (+info)

Pleomorphic carcinoma: report of a case with massive pleural effusion and asbestos particles. (3/25)

Pleomorphic (spindle/giant cell) carcinoma (PC) is one subset of large cell carcinoma. It is well known that PC patients have a poor survival rate. This report describes a 68-year-old man with PC. The patient's tumor had a massive pleural effusion. A left lower lobectomy and partial resection of the left diaphragm, peritoneum, and parietal pleura were performed to remove the tumor. Numerous asbestos particles were found in the left lower lobe. This is the first reported case of PC which may have been caused by asbestos particles. Further investigation is needed into whether asbestos exposure causes PC.  (+info)

Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells. (4/25)

The dysfunction of homologous and/or heterologous gap junctional intercellular communication (GJIC) has been implicated in tumorigenesis of many kinds of cells. Here we have characterized GJIC and the expression of connexins in six human lung carcinoma cell lines and normal lung fibroblasts (HLF). Compared with HLF, all the carcinoma cells showed reduced or little homologous GJIC. They expressed remarkably reduced connexin(Cx)43 mRNA and variable levels of Cx45 mRNA, but neither Cx43 nor Cx45 protein could be detected. However, using a preloading assay, transfer of calcein was observed between donor HLF cells and first order neighboring recipient tumor cells (recipient cells in 1000-fold excess). Transfer from tumor to HLF cells under the same conditions was not seen, although increasing the ratio of donor tumor cells to recipient HLF cells and plating the cells at low density did reveal weak transfer from tumor cells to HLF. Transfection of Cx43 into giant cell carcinoma PG cells increased homologous communication and eliminated the rectifying behavior of heterologous communication. This indicates that the apparent rectification of dye transfer between normal and tumor cells was a product of low rates of heterologous transfer linked to (i) rapid dilution of the dye to below detectable limits through a very well coupled cell population (tumor to HLF) and (ii) concentration of dye in immediate neighbors in a poorly coupled cell population (HLF to tumor cells). These results suggest that the coupling levels may need to exceed a certain threshold to allow propagation of signals over a sufficient distance to affect behavior of a cell population. We propose that the relative rates of heterologous and homologous coupling of cell populations and the 'pool size' of shared metabolites in tumor cells and the surrounding normal tissue are likely to be very important in the regulation of their growth.  (+info)

Clinicopathological features of giant cell carcinoma of the pancreas. (5/25)

BACKGROUND: Giant cell carcinoma of the pancreas (GCCP) as a tumor of high malignancy, large size, and inflammatory reaction occupies 2.1%-12.8% of all cases of pancreatic malignancies. This study was to analyze cases of GCCP collected in 8 years at our hospital in an attempt to describe some features of GCCP in Chinese people. METHODS: The clinicopathological features of 19 patients who had been pathologically diagnosed as having GCCP from 1021 patients with pancreatic malignancies collected by Pancreatic Disease Research Group (PDRG) of Changhai Hospital were retrospectively analyzed compared with those of 96 patients with common pancreatic carcinoma (PC) who were randomly selected from 1002 patients with pancreatic carcinoma. The differences of location, clinical symptoms, imagings, laboratory test, operation and the prognosis of these two groups were defined. RESULTS: Tumors in the head of the pancreas were found in 8 patients (42.1%), and those in the body or tail of the pancreas in 11 (57.9%). The initial symptom was abdominal pain in most patients (57.9%). Abdominal pain (73.7%), dyspepsia (63.2%), weight loss (36.8%) but jaundice were common at the time of diagnosis. The abnormal rates of routine laboratory tests in the GCCP group were lower than those in the common PC group. The assay of tumor markers between the groups of GCCP and common PC was approximately the same. The sensitivity and accuracy of ultrasonography, spiral computed tomography and magnetic resonance imaging were considerably high. Large carcinoma in stage IV was seen in 9 patients or 47.4% of the GCCP group, a rate higher than that in the common PC group. Osteoid formation was found microscopically in some patients, and poorly differentiated tumor cells were found in most patients. The 1-year survival rate was 17.6%, which was lower than that in the common PC group. CONCLUSION: The clinicopathological features of GCCP are different from those of common PC. Imaging tests can be used together with the assay of tumor markers to diagnose GCCP as early as possible and to improve the prognosis of GCCP patients.  (+info)

Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (6/25)

AIM: To analyze the structure and expressions of the protein encoded by an HCC-associated novel gene, lysosome-associated protein transmembrane 4 beta (LAPTM4B). METHODS: Primary structure and fundamental characteristics of LAPTM4B protein were analysed with bioinformatics. Expressions of LAPTM4B in HCC tissues and various cell lines were detected using polyclonal antibodies and Western blot. RESULTS: LAPTM4B encoded two isoforms of proteins with molecular masses 35-ku and 24-ku, respectively. The expression level of LAPTM4B-35 protein in HCC tissues was dramatically upregulated and related to the differentiation status of HCC tissues, and it was also high in some cancer cell lines. Computer analysis showed LAPTM4B was an integral membrane protein with four transmembrane domains. LAPTM4B showed relatively high homology to LAPTM4A and LAPTM5 in various species. CONCLUSION: LAPTM4B gene encoded two isoforms of tetratransmembrane proteins, LAPTM4B-35 and LAPTM4B-24. The expression of LAPTM4B-35 protein is upregulated and associated with poor differentiation in human HCC tissues, and also at high levels in some cancer cell lines. LAPTM4B is an original and conserved protein.  (+info)

Combined osteoclastic giant cell and pleomorphic giant cell tumor of the pancreas: a rarity. An immunohistochemical analysis and review of the literature. (7/25)

CONTEXT: The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome. The origin of these two components within a tumor has long been debated based on the immunohistochemical and ultra-structural analysis. CASE REPORT: Herein we describe a tumor with amalgamation of these two distinct histomorphologies along with a minute focus of well-differentiated ductal adenocarcinoma (on multiple sections) in a 50-year male. On immunohistochemical analysis, osteoclastic giant cells were reactive for CD68 and vimentin confirming histiocytic/mesenchymal derivation whereas pleomorphic giant cells and mononuclear cells were reactive for cytokeratin which proved their epithelial nature. CONCLUSIONS: Although the present case had an equal proportion of both components, it is very important to correctly assess the predominant histology since osteoclastic giant cell tumor has a better prognosis as compared to the more aggressive pleomorphic giant cell carcinoma component.  (+info)

Aggressive giant cell tumour of bone. (8/25)

INTRODUCTION: The surgical treatment of Stage III or aggressive giant cell tumour of the bone, whether to perform intralesional or en-bloc resection, remains controversial. The aim of this study is to identify the effectiveness of en-bloc resection for local control and final oncological outcome of the disease. METHODS: The data of 20 consecutive patients with Stage III giant cell tumour were retrospectively reviewed to determine the local control and oncological outcome after treatment with wide resection. RESULTS: The majority of the patients presented late with mean duration of symptoms of 24 months, and four patients presented with recurrences. All patients were treated with wide resection except for two patients who underwent ablative surgery due to major neurovascular involvement. Ten patients required free vascularised tissue transfer to cover massive soft tissue defect. Local recurrence occurred in one patient who was again treated with wide resection and vascularised flap. Six patients had pulmonary metastases. Two patients with resectable disease were treated with thoracoscopic surgery and they remained disease-free 36 months after surgery. Two patients with multiple lung metastases were treated with chemotherapy and the disease remained non-progressive. The remaining two patients who refused chemotherapy showed radiological progression, and one succumbed to the disease with massive haemoptysis. CONCLUSION: Aggressive giant cell tumour of bone should be treated with wide resection for better local control, and treatment of pulmonary metastases is mandatory for overall prognosis.  (+info)

TY - JOUR. T1 - A case of anaplastic ductal carcinoma (giant cell carcinoma of osteoclastoid type) with portal vein and main pancreatic ductal invasion. AU - Isaka, Toshifumi. AU - Mizuno, Nobumasa. AU - Takahashi, Kuniyuki. AU - Sawaki, Akira. AU - Nakamura, Tsuneya. AU - Tajika, Masahiro. AU - Kawai, Hiroki. AU - Imaoka, Hiroshi. AU - Okamoto, Yasuyuki. AU - Inoue, Hiroyuki. AU - Aoki, Masatoshi. AU - Shimizu, Yasuhiro. AU - Yatabe, Yasushi. AU - Yamao, Kenji. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2005/6. Y1 - 2005/6. UR - UR - M3 - Article. C2 - 15981633. AN - SCOPUS:21044440650. VL - 102. SP - 736. EP - 740. JO - Japanese Journal of Gastroenterology. JF - Japanese Journal of Gastroenterology. SN - 0446-6586. IS - 6. ER - ...
Definition of giant cell carcinoma of thyroid gland. Provided by Stedmans medical dictionary and Includes medical terms and definitions.
Background: Undiffrentiated pleomorphic sarcoma of vulva with osteoclastic giant cells is a diagnosis of exclusion. It is an exceptionally uncommon diagnostic finding which was eventually diagnosed in our institute and this required a methodical clinical approach and extensive immunohistochemical markers to rule out other probable diagnostic possibilities at this site. The quick diagnostic approach at our institute was ensued by operation. Case Report: 53 years old female presented with vulval growth to our institute. Incision biopsy was performed as a routine procedure. Biopsy showed atypical spindle cells with few cells showing rhabdoid morphology and osteoclast like giant cells were also present. Histological findings with aid of immunohistochemistry led to the diagnosis of undifferentiated pleomorphic sarcoma with osteoclast like giant cells. The tumor cells stained intensely for vimentin (a mesenchymal marker), but no immunoreactivity for the Cytokeratin Pan (epithelial cells marker), ...
UCOCGC; poorly differentiated carcinoma with osteoclastic giant cells Images Poorly differentiated carcinoma with osteoclast-like giant cells (...)
INTRODUCTION: Pulmonary Sarcomatoid Carcinoma (PSC) is a rare group of tumors accounting for about 0.4% of non-small cell lung carcinoma (NSCLC). Five subtypes were described: pleomorphic carcinoma, spindle cell carcinoma, carcinosarcoma, giant cell carcinoma and pulmonary blastoma. The diagnosis is pathological but requires a good quality sampling of the tumor.. METHODS: On a series of 1582 patients operated on for lung cancer from 1992 to 2016, 43 patients were retrospectively identified as having been treated surgically for pulmonary sarcomatoid carcinoma.. RESULTS: The population consisted of 33 males and 10 females with mean age of 55 years. Imaging findings showed a peripheral mass in the majority of cases (n=29). Careful investigation failed to discover a primitive lesion elsewhere. Six patients received induction therapy for wall involvement. Lobectomy or bilobectomy was performed in 30 patients and pneumonectomy in 11 patients. A wedge resection was performed in one patient and an ...
The mean age of patients was 56.8 years (range, 46-73 years). The CT appearance of the tumor was similar for all our patients: Large mass, peripheral, heterogeneous density, with massive necrotic tissue component that strongly heightened after contrast injection; tumor had a locoregional extension with parietal and bone invasion (n = 5) and a distance extension (n = 4) to the adrenal glands. Pathological examination found a pleomorphic carcinoma (n = 3), a giant cell carcinoma (n = 1) and a carcinosarcoma (n = 2). Sarcomatoid carcinoma diagnosis was increased for the remaining patients without precision of histological subtype. ...
It has been reported that at the onset of pupariation there is an increase of lipid droplets in PG cells that can be seen by Oil Red O staining of precisely staged 120 h AEL wandering larvae (Talamillo et al., 2013). At 120 h AEL, phm,CTCFRNAi PGs had a reduced content of lipid droplets in comparison to controls (Fig. 4B, compare middle and left panels), likely due to developmental delay. However, there is also an increase of lipid droplets at the end of larval development in phm,CTCFRNAi PG cells which tend to be slightly higher than in control animals (Fig. 4B, compare right and left panels and supplementary material Fig. S4). Since the subcellular lipid accumulation phenotype of phm,CTCFRNAi PG cells is similar to that of Niemann-Pick type C (npc) mutants (Huang et al., 2005), we analyzed dnpc1a transcriptional levels but we found no changes between control and phm,CTCFRNAi larvae (data not shown). Increased lipid accumulation in the fat body in EcR knockdown larvae has been reported ...
We also analyzed the latency and jitter (the SD of the latency) of responses to ON stimulation. Across the entire GAD65+ PG cell population latencies ranged from 1.8 to 8.2 ms (mean: 3.61 ± 0.22 ms; Fig. 3D) and jitter ranged from 30 to 2,616 μs (mean: 470 ± 70 μs; Fig. 3E). However, cells with spontaneous and ON-evoked single EPSCs had significantly lower latency (2.63 ± 0.06 ms, range: 1.79-4.08 ms) and jitter (173 ± 9 μs, range: 31-298 μs) than cells with spontaneous and ON-evoked EPSC bursts (latency: 4.62 ± 0.3 ms, P , 0.000001, range: 2.16-8.20 ms; jitter 774 ± 119 μs, P , 0.000001; range: 309-2,616 μs).. ET cells provide monosynaptic burst input to ∼70% of PG cells (Hayar et al. 2004b). Thus the burst-sEPSC PG cell responses to ON input may derive from the disynaptic, ON→ET→PG circuit. However, mitral/tufted (M/T) cells could also contribute to this burst response: Back propagation of action potentials initiated near the M/T cell soma into the apical dendrites might ...
CBC Normal Adult Values WBC 5,000 - 10,000/mm3 RBC 4.5 - 5.5 million/mm3 (4 - 5 females) Hgb 14 - 17 g/dl (12 - 16 females) Hct 42 - 52% (36 - 48 females) MCV 84 - 96 fL MCH 28 - 34 pg/cell MCHC 32 - 36 g/dl Platelets 140,000 - 400,000/mm3 RDW 11.5 - 14.5% MPV 7.4 - 10.4 fL
A rare case of aneurysmal bone cyst (ABC) located in the mandibular condyle in a 10-year-old boy is presented. The patient came to our attention for a sudden swelling in the right temporomandibular region, the mouth opening was not reduced. A rapid growing mass, depicting soft tissue invasion, in the right condyle of the mandible was found. Clinically and radiographically it resembled to a malignant lesion. The surgical excision of the mandibular condyle allowed a complete removal of the lesion. The histological examination revealed a pseudocystic expanding osteolytic lesion containing blood-filled space separated by connective tissue and many osteoclastic giant cells, which was a conventional vascular ABC. The ABC is an infrequent bone lesion which can only be found very rarely at the craniofacial skeleton. There have been described about 160 cases of ABC originated in the molar region or in upper maxilla and even more rare is the location of this cyst in the mandibular condyle. Only 6 cases were
Supplementary Materialstoxins-12-00196-s001. resembling a natural cyanobacteria bloom. The estimated amount of toxins made by and were 0 respectively.023 pg/cell of microcystin-LR (MC-LR) and 7.854 pg/cell of cylindrospermopsin (CYN). After 15 times of contact with blended and one cyanobacteria, a depuration stage followed, where mussels had been fed only nontoxic microalga and modulate their cleansing and oxidative-stress protection systems after contact with MCs [23,24]. Certainly, contaminants of estuarine and seaside areas produced from the movement of polluted freshwaters from inland to the ocean have already been reported in various geographical locations [25,26,27], constituting a potential thread to sea ecosystems. For instance, high degrees of MCs had been within mussels gathered from SAN FRANCISCO BAY AREA Bay, California [26]. Furthermore, a monitoring research within this estuary demonstrated the fact that contaminants of bivalves with MCs is certainly recurrent being discovered in ...
NGC 6940 is an open cluster in the constellation Vulpecula. It was discovered by William Herschel in 1784. The cluster is nearly a billion years old and it is located 2,500 light years away. It is considered the finest open cluster in the constellation. It is located a bit more than two degrees south-southeast of 41 Cygni and three and a half degrees southwest from 52 Cygni. The cluster is bright enough to be seen even with small binoculars, which can partially resolve it. NGC 6940 is included in the Herschel 400 Catalogue. NGC 6940 has hundreds of members. The cluster is quite scattered and in between its members are also visible field stars. For example, two bright stars, a 8.6 mag B8III giant star at the NE edge and a 9.1 mag A0III giant at the SW corner of the cluster are too young to be true members of NGC 6940 and are probably background stars. The brightest star (lucida) of NGC 6940 is the red giant VG Vulpeculae, a semiregular variable star whose magnitude ranges from 9.0 to 9.5 every 80 ...
Parent of origin imprints on the genome have been implicated in the regulation of neural cell type differentiation. The ability of human parthenogenetic (PG) embryonic stem cells (hpESCs) to undergo neural lineage and cell type-specific differentiation is undefined. We determined the potential of hpESCs to differentiate into various neural subtypes. Concurrently, we examined DNA methylation and expression status of imprinted genes. Under culture conditions promoting neural differentiation, hpESC-derived neural stem cells (hpNSCs) gave rise to glia and neuron-like cells that expressed subtype-specific markers and generated action potentials. Analysis of imprinting in hpESCs and in hpNSCs revealed that maternal-specific gene expression patterns and imprinting marks were generally maintained in PG cells upon differentiation. Our results demonstrate that despite the lack of a paternal genome, hpESCs generate proliferating NSCs that are capable of differentiation into physiologically functional ...
Factor VIII has a domain organization A1-A2-B-A3-C1-C2 and synthesized as single-chain polypeptide of 2351 amino acids, from which you cut the signal peptide of 19 amino acids during translocation into the lumen of the endoplasmic reticulum. Due to the fact that factor VIII is bad glycosylases, it was difficult to achieve a high expression level (,0.2 PG/cell/day) factor VIII (Lind et al., 1995, Eur J Biochem. 232: 19-27; Kaufman et al., 1989, Mol Cell Biol. 9: 1233-1242). Expression of factor VIII in mammalian cells usually 2-3 orders of magnitude lower than the expression of other genes using similar vectors and techniques. The productivity of cell lines to obtain factor VIII is in the range of 0.5-1 MCED/KL/d (0.1-0.2 PG/CL/d).. It was shown that the B-domain of factor VIII is irrelevant to protagonizada activity. Different groups reported improvement in the expression of factor VIII in mammalian cells using truncated variants of factor VIII (Lind et al., 1995, Eur J Biochem 232: 19-27; ...
Read chapter 5 of Hematology in Clinical Practice, 5e online now, exclusively on AccessBiomedical Science. AccessBiomedical Science is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine.
Mouden C, de Tayrac M, Dubourg C, Rose S, Carré W, Hamdi-Rozé H, Akloul L, Héron B, Odent S, Dupé V, Giet R, David V. PLoS One. 2015 Feb.. Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates. Godard BG, Coolen M, Le Panse S, Gombault A, Ferreiro-Galve S, Laguerre L, Lagadec R, Wincker P, Poulain J, Da Silva C, Kuraku S, Carre W, Boutet A, Mazan S. Biol. Open. 2014 Oct.. Bacterial protein signals are associated with Crohns disease. Juste C, Kreil DP, Beauvallet C, Guillot A, Vaca S, Carapito C, Mondot S, Sykacek P, Sokol H, Blon F, Lepercq P, Levenez F, Valot B, Carré W, Loux V, Pons N, David O, Schaeffer B, Lepage P, Martin P, Monnet V, Seksik P, Beaugerie L, Ehrlich SD, Gibrat JF, Van Dorsselaer A, Doré J. Gut. 2014 Oct.. Dietary intervention impact on gut microbial gene richness. Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, Almeida M, Quinquis B, Levenez F, Galleron N, Gougis S, Rizkalla S, Batto ...
A giant cell tumor is one that is made up of a large number of benign (noncancerous) cells that form an aggressive tumor, usually near the end of the bone near a joint. The location of a giant cell tumor is often in the knee, but can also involve the bones of the arms and the legs, or the flat bones such as the sternum (breastbone) or pelvis.. Giant cell tumors most often occur in young adults when skeletal bone growth is complete. Most occur in the long bones of the legs and arms.. ...
Giant cell tumor of bone is a rare, fast-growing noncancer tumor. It often grows near a joint at the end of a bone. Read on to learn about symptoms, diagnosis, and treatment.
Giant Cell Tumor A giant cell tumor is one that is made up of a large number of benign (noncancerous) cells that form an aggressive tumor. It usually develops near a joint at the end of the bone. The location of a giant cell tumor is often in the knee, .... ...
Health and wellness is a very popular topic. There are numbers of businesses, books, movies and websites dedicated to the topic. Each doctor or wellness expert has their own research and opinions on how to achieve optimum health which can be overwhelming. Good health doesnt have to mean expensive treatments and supplements, it can be…
Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with homogenous distribution. There is no widely held consensus regarding the ideal treatment method selection. There are advocates of varying surgical techniques ranging from intra-lesional curettage to wide resection. As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional approach that preserves anatomy of bone in lieu of resection. Although GCT is classified as a benign lesion, few patients develop progressive lung metastases with poor outcomes. Treatment is mainly surgical. Options of
TY - JOUR. T1 - In situ cell cycle analysis in giant cell tumor of bone reveals patients with elevated risk of reduced progression-free survival. AU - Mate, Maros E.. AU - Sven, Schnaidt. AU - Peter, Balla. AU - Zoltan, Kelemen. AU - Zoltan, Sapi. AU - Szendrői, M.. AU - Tamas, Laszlo. AU - Ramses, Forsyth. AU - Piero, Picci. AU - Krenács, T.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Objective: Giant cell tumor of bone (GCTB) is a frequently recurring locally aggressive osteolytic lesion, where pathological osteoclastogenesis and bone destruction are driven by neoplastic stromal cells. Here, we studied if cell cycle fractions within the mononuclear cell compartment of GCTB can predict its progression-free survival (PFS). Methods: 154 cases (100 primaries and 54 recurrent) from 139 patients of 40 progression events, was studied using tissue microarrays. Ploidy and in situ cell cycle progression related proteins including Ki67 and those linked with replication licensing (mcm2), G1-phase (cyclin D1, ...
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Pat Shurmur cant say it. At least not as directly as he might like to. It would go against his rule of making excuses, and given the dilapidated conditions the Giants currently reside in with a 2-8 r
TY - JOUR. T1 - Techniques in the management of juxta-articular aggressive and recurrent giant cell tumors around the knee. AU - Vidyadhara, S.. AU - Rao, S. K.. PY - 2007/3. Y1 - 2007/3. N2 - Aim: Juxta-articular aggressive and recurrent giant cell tumors around the knee pose difficulties in management. This article reviews current problems and options in the management of these giant cell tumors. Methods: A systematic search was performed on juxta-articular aggressive and recurrent giant cell tumor. Additional information was retrieved from hand searching the literature and from relevant congress proceedings. We addressed the following issues: general consensus on early diagnosis and techniques in its management. In particular, we describe our results with resection arthrodesis performed combining the benefits of both interlocking intramedullary nail and Ilizarov fixator in the management of these tumors around the knee. Results: Mean operative age of the 22 patients undergoing resection ...
From UniProt:. Porokeratosis 8, disseminated superficial actinic type (POROK8): A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype. It is characterized by multiple small, annular, anhidrotic, keratotic lesions that are located predominantly on sun-exposed areas of the skin, such as the face, neck, and distal limbs. The lesions typically begin to develop in adolescence and reach near-complete penetrance by the third or fourth decade of life. ...
Cooper and Travers first described giant cell tumor (GCT) of bone in 1818. GCTs of bone have been described as the most challenging benign bone tumors.
Vittoria Espeli* and Cristina Mangas-A Case of Eruptive Disseminated Porokeratosis in a Cancer Patient after Trastuzumab and Exemestane Treatment: Cancer Related or Drug Induced Phenomenon?
(HealthDay)-Xgeva (denosumab) has been approved by the U.S. Food and Drug Administration to treat giant cell tumor of the bone (GCTB), a rare tumor thats most often non-cancerous.
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TY - JOUR. T1 - Topical cholesterol/lovastatin for the treatment of porokeratosis. T2 - A pathogenesis-directed therapy. AU - Atzmony, Lihi. AU - Lim, Young H.. AU - Hamilton, Claire. AU - Leventhal, Jonathan S.. AU - Wagner, Annette. AU - Paller, Amy S.. AU - Choate, Keith A.. PY - 2020/1. Y1 - 2020/1. N2 - Background: Porokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. We hypothesized that topical therapy that aims to replenish cholesterol, an essential mevalonate pathway end-product, and block the accumulation of mevalonate pathway toxic metabolites could alleviate porokeratosis. Objective: To study the efficacy of topical cholesterol/lovastatin in different variants of porokeratosis. Methods: We enrolled a series of 5 porokeratosis patients,1 with disseminated superficial actinic porokeratosis, 2 with porokeratosis palmaris et plantaris disseminata, and 2 with linear porokeratosis. Patients were genotyped before ...
Giant cell tumors of the bone are uncommon bone tumors which represent around 4-5% of primary bone tumors and 18% of all benign bone lesions. They are interesting in the fact that their classic radiographic appearance is easily identifiable. Giant cell tumors can either be benign or malignant, although the majority of them are benign. Radiographically, benign versus malignant tumors are difficult to distinguish. In most patients, the tumor has an indolent course, but repeated local recurrence of the tumor does happen. Approximately 5% of giant cell tumors are defined as malignant. Malignancy usually occurs as the result of malignant transformation after radiation therapy. These tumors are slightly more common in females, with 50-57% of cases occurring in females. The general age range for giant cell tumors is 20-40 years old. Approximately 85% of tumors occur in the long bones, namely the distal femur, proximal tibia, proximal humerus, and distal radius. Another location typical of giant cell ...
Understanding Giant cell tumor (GCT) of bone has been described as the most challenging benign bone tumors. The majority of these tumors, classically, are involved in the epiphysis of long bones. Although this disorder is benign, GCTs show a tendency of bone destruction, local recurrence and, occasionally, pulmonary metastasis. But axillary lymohnode metastasis is very very rare. Herein, we present an extremely rare case of axillary mets even after below elbow amputation in a case of recurrent giant cell tumor in a 45 yers male residing at Kolkat,.West Bengal. We treat him by radical axillary lumph node dissection.Lymph node histopatho;ogical report shows Tartrate-resistant acid phosphatase (TRAP) activity.. ...
Definition of porokeratosis - Originally (more fully porokeratosis of Mibelli): an inherited (autosomal dominant) disorder of the skin characterized by the pr
La traduzione di Awaken the giant (Risveglia il gigante), testo tradotto di Awaken the giant degli Stratovarius, quinta traccia dellalbum Elements pt.2
This poem is a continuation of the adventures between a Giant Boy and his Giant Father. This time they decide to construct a moving vehicle.
Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... "giant-cell carcinoma" should be limited strictly to neoplasms containing only malignant giant cells (i.e. "pure" giant-cell ... Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated ... The cells from giant-cell carcinomas are anaplastic, and show no evidence of cell maturation or differentiation, lacking the ...
... of hepatocellular carcinoma are: fibrolamellar, pseudoglandular (adenoid), pleomorphic (giant cell), and clear cell. In well- ... In poorly differentiated forms, malignant epithelial cells are discohesive, pleomorphic, anaplastic, and giant. The tumor has a ... "Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells". Biochemical ... apoptosis and cell cycle arrest in human HCC cell lines without accompanying cytotoxicity. Thus, IGF-1R-TK inhibition may be a ...
... especially with carcinoma. Giant cell tumors include giant-cell tumor of bone, giant-cell tumor of the tendon sheath, and giant ... Overview at Mayo Clinic Large Cell and Giant Cell Carcinoma,+Giant+Cell at the US National Library of Medicine Medical Subject ... Medicine portal Anaplastic large-cell lymphoma Buttock cell Nosology Giant+Cell+Tumors at the US National Library of Medicine ... Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are ...
These classifications are spindle cell, squamous cells, matrix-producing, carcinosarcoma, and MCB with osteoclastic giant cell ... The epithelial-type is further classified as squamous cell carcinoma, adenocarcinoma with spindle cell differentiation, and ... proposed a classification system consisting of spindle cell carcinoma, invasive ductal carcinoma with extensive squamous ... Metaplastic carcinoma, otherwise known as metaplastic carcinoma of the breast (MCB), is a heterogeneous group of cancers that ...
Billy Hinsche, 70, American musician (Dino, Desi & Billy, The Beach Boys), giant cell carcinoma. Alberto Labarthe, 93, Chilean ... Sam Huff, 87, American Hall of Fame football player (New York Giants, Washington Redskins) and commentator. Jack Kiddey, 92, ... Lee Ying-yuan, 68, Taiwanese politician, member of the Legislative Yuan (1996-2000, 2012-2016), carcinoma of the ampulla of ... Gentle giant' who won gold and worked as Cavern doorman dies at 87 85岁德国钱币学者布威纳逝世,终生研究中国清代钱币 (in
"Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: report of a case with osteochondroid differentiation". ... giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance ... However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can ... O'Reilly D, Greaves DR (September 2007). "Cell-type-specific expression of the human CD68 gene is associated with changes in ...
Anaplasia Cell growth Cytopathology Giant cell carcinoma of the lung Nuclear atypia Schmoller, Kurt M.; Skotheim, Jan M. ( ... Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of ... December 2015). "The Biosynthetic Basis of Cell Size Control". Trends Cell Biol. 25 (12): 793-802. doi:10.1016/j.tcb.2015.10. ... Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and ...
Giant Cell Tumor of Hyperparathyroidism)". University of Pittsburgh School of Medicine. Retrieved 2008-11-17. Delmez, James ( ... Parathyroid carcinoma Parathyroid carcinoma (cancer of the parathyroid gland) is the rarest cause of OFC, accounting for about ... These cells are characteristically benign, feature a dense, granular cytoplasm, and a nucleus that tends to be ovular in shape ... Parathyroid carcinoma accounts for less than 1% of all cases, occurring most frequently in individuals around 50 years of age ( ...
One study compared the enzymes of liver metastases of giant-cell lung carcinoma and nonmalignant placental cells. The two were ... embryonic stem cells or embryonal carcinoma cells). There is a positive correlation between serum bone alkaline phosphatase ... "Appendix E: Stem Cell Markers". Stem Cell Information. National Institutes of Health, U.S. Department of Health and Human ... Leukocyte alkaline phosphatase is found within mature white blood cells. White blood cell levels of LAP can help in the ...
Syncytiotrophoblast giant cells also occur in polyembryomas. Primary ovarian squamous cell carcinomas are rare and have a poor ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... The ovary is made up of three different cell types including epithelial cells, germ cells, and stromal cells. When these cells ... Clear cell ovarian carcinoma is a rare subtype of epithelial ovarian cancer. Those diagnosed with clear cell ovarian carcinoma ...
However, as HGSC tends to have the same clinical behaviour, regardless of its primary cell origin, determining cell origin is ... Distinguishing between LGSC and HGSC: Necrosis is common in HGSC and absent in LGSC, as are giant (multi- or mononucleated) ... Technically a 'serous carcinoma' can occur anywhere on these membranes, but high-grade serous carcinoma is generally limited to ... tumour cells. Psammoma bodies are more frequent in low-grade serous carcinoma. Tp53 expression is assessed for mutations, ...
In this group are: pleomorphic carcinoma, carcinoma with osteoclast-like stromal giant cells, carcinoma with ... Cells with too much or too little DNA are called aneuploid. Aneuploid cells are more likely to spread than diploid cells. DNA ... Invasive ductal carcinoma, with occasional entrapped normal ducts (arrow) The appearance of cancer cells under a microscope is ... Invasive carcinoma of no special type (NST) also known as invasive ductal carcinoma or ductal NOS and previously known as ...
... analysis of the fate of giant cells produced by X-irradiating EJ30 human bladder carcinoma cells". Radiation Research. 159 (6 ... Cells that do not immediately die are likely to create aneuploid cells following subsequent attempts at cell division posing a ... v t e (Cell cycle, Mitosis, Cancer, All stub articles, Cell cycle stubs). ... Mitotic catastrophe is unrelated to programmed cell death and is observed in cells lacking functional apoptotic pathways. It ...
Giant-cell carcinoma of the lung Basaloid large cell carcinoma of the lung Clear cell carcinoma of the lung Lymphoepithelioma- ... like carcinoma of the lung Large-cell lung carcinoma with rhabdoid phenotype Large cell neuroendocrine carcinoma of the lung ... LCC is categorized as a type of NSCLC (non-small-cell lung carcinoma) which originates from epithelial cells of the lung. ... "large-cell neuroendocrine carcinoma" (LCNEC), which is believed to derive from neuroendocrine cells. In addition, a "subvariant ...
... pleomorphic carcinoma, (2) spindle cell carcinoma, (3) giant cell carcinoma, (4) carcinosarcoma, or (5) pulmonary blastoma. ... Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Approximately 98% of lung cancers are carcinoma, a term for malignant neoplasms derived from cells of epithelial lineage, and/ ... Carcinoid tumor Salivary gland-like carcinoma Sarcomatoid carcinomas are unique among lung carcinomas in that, although they ...
... it can be classified into giant cell carcinoma (almost completely consists of giant cells), spindle cell carcinoma (almost ... pleomorphic carcinoma (at least 10% spindle/giant cells or consists of giant and spindle cells only), carcinosarcoma (mix of ... Sarcomatoid carcinoma is a type of rare lung tumour under the category of poorly differentiated Non-small-cell lung carcinoma ( ... Moran C, Saul S (2010). "Non Small Cell Carcinomas of the Lung". Tumors and Tumor-like Conditions of the Lung and Pleura. ...
... colloid carcinomas, undifferentiated carcinomas, and undifferentiated carcinomas with osteoclast-like giant cells. Solid ... Other exocrine cancers include adenosquamous carcinomas, signet ring cell carcinomas, hepatoid carcinomas, ... The next-most common type, acinar cell carcinoma of the pancreas, arises in the clusters of cells that produce these enzymes, ... Like the 'functioning' endocrine cancers described below, acinar cell carcinomas may cause over-production of certain molecules ...
... oral squamous cell carcinoma) as well. It was shown that OSCC cells had a suppressed response to DPT. DPT expression had an ... is a biomarker for giant-cell tumor of bone (GCTB).[unreliable medical source] There is also a relationship between CCW ( ... Cell adhesion is the effect of the cell behavior due to the function of the dermatopontin. Even though, cell adhesion activity ... These connections also facilitate cell-to-cell communication (1). Dermatopontin mediates adhesion by cell surface integrin ...
There are many tumors in the differential diagnosis, including spindle cell melanoma, spindle cell squamous cell carcinoma, ... Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical ... tumour cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged ... Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing. ...
... spindle cell carcinoma, and giant cell carcinoma. Giant cell carcinoma components are seen much more commonly in patients who ... Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... December 1982). "The clinical behavior of "mixed" small cell/large cell bronchogenic carcinoma compared to "pure" small cell ... combined small cell carcinoma of the lung has been long classified as a subset of small cell carcinoma, and not as a subset of ...
... giant cell fibroblastoma, granulocytic sarcoma, Kaposi's sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant ... and papillary thyroid carcinoma. A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ...
In a recent study of patients with Renal cell carcinoma, resistance to Temsirolimus was associated with low levels of p-AKT and ... subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis (TS), and progressive neuroendocrine tumors of ... From March 30, 2009 to May 5, 2011 the U.S. FDA approved everolimus for the treatment of advanced renal cell carcinoma after ... A G0-G1 cell-cycle blockage can be the consequence of inactivation of mTOR in hypoxia-activated pericytes and endothelial cells ...
... goitre Paget's disease Polymyalgia rheumatica Giant cell arteritis Fibromuscular dysplasia IgG4-related disease Carotid bruit ... which may be caused by a cranial artery bruit Arteriovenous malformation Coarctation of the aorta Hepatocellular carcinoma ...
... it has been found that C1orf142 has larger expression rates in cell line of giant cell lung carcinoma they have high metastatic ... PVR binds to CD96 and CD226 - Natural killer cell receptors. This can cause PVR to possibly be transferred to NK cells and ... The poliovirus receptor plays a role in cell motility during tumor cell invasion and migration. ... and COTL1 in Non-Small Cell Lung Cancer Cell Lines With Different Tumor Metastatic Potential". Journal of Investigative ...
Pleomorphic carcinoma M8030/3 Giant cell and spindle cell carcinoma M8031/3 Giant cell carcinoma M8032/3 Spindle cell carcinoma ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma ... cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell ...
Giant cells - considerably larger than their neighbors - may form and possess either one enormous nucleus or several nuclei ( ... Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus tumor, Colloid cyst, Dysembryoplastic neuroepithelial tumour ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ...
... hyalinizing spindle cell fused with giant rosette, endometrial stromal sarcoma with hyalinizing giant rosettes, embryonal tumor ... Merkel cell carcinoma, neuroendocrine tumor of skin, seborrheic keratosis, dendritic cell neurofibroma, astroblastoma, large ... Kadono T, Okada H, Okuno T, Ohara K (June 1998). "Basal cell carcinoma with neuroid type nuclear palisading: a report of three ... It can also be seen in nodular basal-cell carcinomas. Pseudopalisading, a visually similar finding, is the formation of ...
neoplasm benign neoplasms, such as fibromas, papillomas and giant cell granulomas malignant neoplasms, such as a carcinoma or ... Hyperplasia refers to an increased number of cells, and hypertrophy refers to an increase in the size of individual cells. As ... Subramani, T; Rathnavelu, V; Yeap, SK; Alitheen, NB (Feb 2013). "Influence of mast cells in drug-induced gingival overgrowth". ...
Characteristic for granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes around lobules. Often ... Because it is so rare it may be sometimes confused with comedo carcinoma of the breast although the conditions appear to be ... ISBN 978-0-397-51624-7. Liong, Yee; Hong, Ga; Teo, Jennifer Gek; Lim, Geok (2013). "Breast ductal carcinoma in situ presenting ...
March 2006). "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma". Carcinogenesis. 27 ... "Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells". Biology of Reproduction. 74 (6): 1041-50 ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... Przyborski SA (2001). "Isolation of human embryonal carcinoma stem cells by immunomagnetic sorting". Stem Cells. 19 (6): 500-4 ...
Revealed: how oil giant influenced Bush, White House sought advice from Exxon on Kyoto stance John Vidal. The Guardian, June 8 ... "In contrast, abortion is associated with increased risk of carcinomas of the breast. The explanation for these epidemiological ... accused the administration in July 2007 of political interference and muzzling him on key issues like embryonic stem cell ... findings is not known, but the parallelism between the DMBA-induced rat mammary carcinoma model and the human situation is ...
In May 1996, Butler learned that he was suffering from squamous cell carcinoma of the tonsils, a type of cancer which only ... He helped the Giants to the NL pennant in 1989, as the leadoff hitter in a lineup that included Will Clark, Kevin Mitchell, and ... Butler signed with the San Francisco Giants as a free agent after the 1987 season and established himself as one of the premier ... San Francisco Giants players, Southeastern Oklahoma State Savage Storm baseball players, International League MVP award winners ...
... squamous cell Carcinoma, squamous cell of head and neck Carcinophobia Cardiac amyloidosis Cardiac and laterality defects ... Congenital fiber type disproportion Congenital gastrointestinal disorder Congenital generalized fibromatosis Congenital giant ... syndrome Carbon baby syndrome Carbonic anhydrase II deficiency Carcinoid syndrome Carcinoma of the vocal tract Carcinoma, ... anthrax Cutaneous larva migrans Cutaneous lupus erythematosus Cutaneous photosensitivity colitis lethal Cutaneous T-cell ...
Characteristic for idiopathic granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes forming non- ... foreign body reaction and granulomatous reaction in a carcinoma must be excluded. The condition is diagnosed very rarely. As ... "A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: Idiopathic granulomatous mastitis". The Breast. ...
Cell. 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573. Sulem P, Gudbjartsson DF, Stacey SN, ... HERC2 is a giant E3 ubiquitin protein ligase, implicated in DNA repair regulation, pigmentation and neurological disorders. It ... UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability". Pathology. 43 (7): 753-5. doi:10.1097/ ... It is involved in coordinating the Chk1-directed DNA damage/cell cycle checkpoint response by regulating the stability of the ...
... such as giant cell carcinoma, spindle cell carcinoma and small-cell carcinoma. An invasive ductal carcinoma of the breast (pale ... For a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be altered. The ... hepatocellular carcinoma) and human T-cell leukemia virus-1 (T-cell leukemias). Bacterial infection may also increase the risk ... These types include: Carcinoma: Cancers derived from epithelial cells. This group includes many of the most common cancers and ...
Giant cell change and other features of hepatocellular injury are more pronounced in PFIC-2 than in PFIC-1 or PFIC-3. End-stage ... Hepatocellular carcinoma may develop in PFIC-2 at a very early age; even toddlers have been affected.[citation needed] ... Retention of bile salts within hepatocytes, which are the only cell type to express BSEP, causes hepatocellular damage and ... as the pathology is due to a transporter as opposed to an anatomical problem with biliary cells.[citation needed] Initial ...
... and trichoblastic carcinomas, respectively. Some of these tumors resemble basal-cell carcinomas or adenocarcinomas. These ... Teli B, Thrishuli PB, Santhosh R, Amar DN, Rajpurohit S (2015). "Giant solitary trichoepithelioma". South Asian Journal of ... Inactivating CYLD gene mutations occur in T-Cell Acute Lymphoblastic Leukemia, multiple myeloma, hepatocellular carcinoma, ... Kallam AR, Satyanarayana MA, Aryasomayajula S, Krishna BA (March 2016). "Basal Cell Carcinoma Developing from Trichoepithelioma ...
Solitary trichoepithelioma Spindle cell squamous cell carcinoma (spindle cell carcinoma) Spiradenoma Squamous cell carcinoma ... Giant cell fibroblastoma Giant cell tumor of the tendon sheath (giant cell synovioma, localized nodular tenosynovitis, ... pale cell acanthoma) Clear cell squamous cell carcinoma (clear cell carcinoma of the skin) Chronic scar keratosis (chronic ... Merkel cell carcinoma (cutaneous apudoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the ...
Bernat AL, Bonnin S, Labidi M, Aldahak N, Bresson D, Bouazza S, Froelich S (2018). "Regression of Giant Olfactory Groove ... Watanabe S, Yamasaki S, Tanae A, Hibi I, Honna T (December 1994). "Three cases of hepatocellular carcinoma among cyproterone ... Stalvey JR (July 2002). "Inhibition of 3beta-hydroxysteroid dehydrogenase-isomerase in mouse adrenal cells: a direct effect of ... Ohri SK, Gaer JA, Keane PF (February 1991). "Hepatocellular carcinoma and treatment with cyproterone acetate". Br J Urol. 67 (2 ...
Tuan Tuan, 18, Chinese giant panda, euthanized. James Winburn, 85, American stuntman (Halloween, The Stunt Man, Pale Rider), ... primary peritoneal carcinoma. Sylvia La Torre, 89, Filipino actress (One Two Bato, Three Four Bapor) and singer. Lu Zhuguo, 94 ... Revolutionary Cells). Oleksandr Kostin [uk], 83, Ukrainian composer. Lê Lựu, 79, Vietnamese writer. Carlos Pacheco, 60, Spanish ... Giant Panda Tuan Tuan passes away at Taipei Zoo James Winburn, Michael Myers stuntman from original Halloween film, dies at 85 ...
May 2011). "Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus". Journal of ... After several studies conclusively linked mTOR inhibitors to remission in TSC tumors, specifically subependymal giant-cell ... It is a mechanistic target of rapamycin kinase (mTOR) inhibitor that inhibits activation of T cells and B cells by reducing ... inhibiting cytotoxic T cells and lowering the differentiation of effector T cells. Rapamycin is used in biology research as an ...
FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma; 144700; RNF139 Renal cell ... TBXAS1 Giant axonal neuropathy-1; 256850; GAN Gillespie syndrome; 206700; PAX6 Gitelman syndrome; 263800; SLC12A3 Glanzmann ... OGG1 Renal cell carcinoma, papillary, 1; 605074; PRCC Renal cell carcinoma, papillary, 1; 605074; TFE3 Renal cell carcinoma, ... CLCNKA Basal cell carcinoma, somatic; 605462; PTCH1 Basal cell carcinoma, somatic; 605462; PTCH2 Basal cell carcinoma, somatic ...
Big Rude Jake, 57, Canadian musician, small-cell carcinoma. Tony Boskovic, 89, Australian soccer referee. John Sears Casey, 91 ... Hugh McElhenny, 93, American Hall of Fame football player (San Francisco 49ers, Minnesota Vikings, New York Giants). John ... squamous cell carcinoma. Miryam Romero, 59, Spanish journalist and television presenter, leukemia. Jim Ryan, 76, American ...
... lobular carcinoma in situ, invasive lobular carcinoma, ductal carcinoma in situ, and invasive ductal carcinoma. A positive ... In a study of 10 individuals with PB, 5 had tumor cells with mutations in the PIK3CA gene and 2 had tumor cells with mutations ... El-Saify WM (2007). "Florid papillomatosis: A rare cause of bilateral giant breast lumps in the elderly". The Breast Journal. ... lobular carcinoma, ductal carcinoma in situ, invasive ductal carcinomas of no special type, Cowden disease, Noonan syndrome, ...
"Giant pristine coral reef discovered off Tahiti". BBC News. 20 January 2022. Archived from the original on 20 January 2022. ... "These solar panels pull in water vapor to grow crops in the desert". Cell Press. Retrieved 18 April 2022. Li, Renyuan; Wu, ... "Fluorescence lifetime needle optical biopsy discriminates hepatocellular carcinoma". Biomedical Optics Express. 13 (2): 633-646 ... Results from a study imply "that all living cells probably possess a common mechanism of [methane] formation". This universal ...
... (VC) is an uncommon variant of squamous cell carcinoma. This form of cancer is often seen in those who chew ... Philippou P, Kitsios C, Miliatou M, Poullou C, Konstantinou P (2019). "Organ-Sparing Surgery for a Giant Verrucous Carcinoma of ... Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis ... Epithelioma cuniculatum (also known as Carcinoma cuniculatum,: 654 and Ackerman tumor) is a subtype of verrucous carcinoma, ...
... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ... giant cell tumors MeSH C04.557.450.565.380.380 - giant cell tumor of bone MeSH C04.557.450.565.465 - mastocytosis MeSH C04.557. ... basal cell MeSH C04.557.470.565.165 - carcinoma, basal cell MeSH C04.557.470.565.165.150 - basal cell nevus syndrome MeSH ...
Maruno K, Said SI (1993). "Small-cell lung carcinoma: inhibition of proliferation by vasoactive intestinal peptide and ... The Gila monster starred as a monster in the film The Giant Gila Monster (though the titular monster was actually portrayed by ...
The tumor cells in LGO contain either supernumerary ring sSMCs or giant rod-shaped marker chromosomes (also termed giant rod ... being present in the malignant cells of most cases of this disease. Transitional cell bladder carcinomas associated with this ... The neoplastic cells in ALT contain one or more ring-shaped sSMCs or one giant marker chromosome (i.e. a chromosome enlarged by ... sSMC i(5)(p10) is the single most common recurrent structural chromosomal abnormality in transitional cell carcinomas of the ...
Skin ulcers can resemble those caused by leishmaniasis, yaws, squamous cell carcinoma, Haemophilus ducreyi infection, and ... A role for biting insects in transmission has been investigated, with particular focus on mosquitoes, giant water bugs, and ... leaving ulcers largely free of immune cells. Immune cells that do reach the ulcer are killed by mycolactone, and tissue ... Mycolactone diffuses into host cells and blocks the action of Sec61, the molecular channel that serves as a gateway to the ...
Merkel cell carcinoma. Alfred Niepieklo, 86, German footballer. Mary Lou Petty, 98, American Olympic swimmer (1936). ... Eski milli basketbolcu Turhan Tezol vefat etti (in Turkish) RIP - The Birth World Mourns The Loss Of Giants Marsden Wagner And ... obituary Former legislative giant Stan Turley dead at 93 עו"ד יגאל ארנון הלך לעולמו בגיל 84 (in Hebrew) Former Real Madrid, ... New York Giants), heart attack. Bill Klucas, 72, American basketball coach, journalist and political consultant, liver cancer. ...
Pleomorphic cells and tumour giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. ... Anaplastic thyroid carcinoma with osteoclast-like giant cells.. Authors: Valand, A G. Ramraje, Sushma N. Pandeya, B S. Shedge, ... Valand AG, Ramraje SN, Pandeya BS, Shedge R, Aware S. Anaplastic thyroid carcinoma with osteoclast-like giant cells. Journal of ... A case of anaplastic thyroid carcinoma with osteoclast-like giant cells is reported. This is an unusual malignant thyroid ...
The focal lesion had PAX8 positive and HMB45 negative cells, compatible with a renal cell carcinoma clear cell variant, and was ... Collision Tumor of the Kidney: Renal Cell Carcinoma Hidden in a Giant Angiomyolipoma in a Patient With Tuberous Sclerosis ... Collision Tumor of the Kidney: Renal Cell Carcinoma Hidden in a Giant Angiomyolipoma in a Patient With Tuberous Sclerosis ... Collision Tumor of the Kidney: Renal Cell Carcinoma Hidden in a Giant Angiomyolipoma in a Patient With Tuberous Sclerosis ...
Keywords: Merkel cell carcinoma, giant, face. Y zde Yerle en Dev Merkel H creli Karsinom. Sava Yayl 1, Sibel Tu cugil1, K ksal ... Giant Merkel Cell Carcinoma Involving the Face. Sava Yayl 1, Sibel Tu cugil1, K ksal Alpay2, Kadriye Y ld z3, Ahmet Nebio lu3, ... Sava Yayl , Sibel Tu cugil, K ksal Alpay, Kadriye Y ld z, Ahmet Nebio lu, Sevgi Bahad r. Giant Merkel Cell Carcinoma Involving ... In this report, we aimed to underline the importance of early diagnosis while presenting a case of giant Merkel cell carcinoma ...
Squamous cell carcinoma is the most common malignant histologic type (approximately 70-80%) followed by adenoid cystic ... Clinical assessment of squamous cell carcinoma of the nasal cavity proper. Auris Nasus Larynx. 1995. 22(3):172-7. [QxMD MEDLINE ... Neoadjuvant chemotherapy for locoregionally advanced squamous cell carcinoma of the paranasal sinuses. Cancer. 2021 Feb 10. [ ... Adenoid cystic carcinoma of the sinonasal tract: treatment results. Laryngoscope. 2006 Jun. 116(6):982-6. [QxMD MEDLINE Link]. ...
Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand. PubMed, SCI, Scopus, ESCI, PMC ... In this paper, we review the subject addressed and report the case of a patient with giant squamous cell carcinoma in one hand ... Surgery Associated with Radiotherapy for Treatment of Giant Squamous Cell Carcinoma in Hand. Author(s): Bruna Mizobutsi Mendes ... Squamous cell carcinoma is the most common tumor in the hand, with actinic keratosis being its precursor lesion. It is a common ...
Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells. ... with microscopic heterogeneous mononuclear cells and scattered osteoclast-like giant cells of various sizes. One patient (1/4) ... and follow-up results of four patients diagnosed with pancreatic undifferentiated carcinoma with osteoclast-like giant cells ... the pathological and genetic characteristics of pancreatic undifferentiated carcinoma with osteoclast-like giant cells and the ...
Myiasis in a giant squamous cell carcinoma. J Am Acad Dermatol. 2006;54:740-1. DOIPubMedGoogle Scholar ... We treated a homeless man in Iran with a history of squamous cell carcinoma who had ophthalmomyiasis caused by Chrysomya ... After 2 years, the patient observed recurrence of the squamous cell carcinoma, but he did not seek further evaluation and ... A 75-year-old man with ophthalmomyiasis after periocular squamous cell carcinoma, Iran. A) Extensive tissue necrosis and the ...
Small or large cell carcinoma. *Intraductal oncocytic papillary neoplasms. *Osteoclast-like giant cell tumors ... mesothelin-specific T-cell response, and the degree of local eosinophil, macrophage, and T-cell infiltration at the vaccine ... Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. Drugs ... and T cell infiltration at the vaccine site, and mesothelin-specific T cell responses. ...
A Giant Squamous Cell Carcinoma in a Patient with Pilonidal Sinus: A Case Report. Talal Alshareef1, Raief Alfriedy1, Ruba ... Alshareef T, Alfriedy R, Aldhaheri R, Arab N, Badahdah F. A Giant Squamous Cell Carcinoma in a Patient with Pilonidal Sinus: A ... In rare cases, longstanding inflammation can lead to malignant transformation, most commonly to Squamous Cell Carcinoma (SCC), ... Finally, surgery is the mainstay of treatment even in giant tumors, and in some cases, it should be followed by radiotherapy to ...
... with osteoclast like giant cells: an extremely unusual finding in fine needle aspiration cytology ...
A giant basal cell carcinoma with lymph node metastasis: a case report and review of the literature . Contemp Surg 1988; 32: 33 ... Actinic keratosis, basal cell carcinoma and squamous cell carcinoma . En: Bolognia J, Jorizzo JL, Schaffer JV, Dermatology, vol ... Giant basal cell carcinoma with metastases and secondary amyloidosis: a report of a case . Acta Derm Venereol 1983; 63: 564-567 ... Two giant basal cell carcinomas presenting simultaneously in the same patient, one resulting in lower extremity limb loss . Ann ...
Histology revealed granulomatous inflammation associated with Langhans giant cells (Figure 2) suggesting mycobacterial ... Massive Primary Hepatic Tuberculoma Mimicking Hepatocellular Carcinoma in an Immunocompetent Host Matthew J. Brookes, MB ChB; ... Cite this: Massive Primary Hepatic Tuberculoma Mimicking Hepatocellular Carcinoma in an Immunocompetent Host - Medscape - Jul ... Histology revealing a granulomatous inflammation, little preservation of liver architecture, and presence of Langhans cells ( ...
It is now recognized that superficial bladder carcinomas are a heterogenous group of tumors with diverse biological and ... This review will discuss recent progress and controversial issues on the staging and substaging of bladder carcinomas. ... 1973 nor the 2004 WHO grading system appears to be useful for predicting the clinical outcome of invasive urothelial carcinoma ... which display alarming cellular atypia similar to giant cell cystitis. This feature, although a helpful clue to invasion, ...
Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. It is rare, and ... Medullary carcinoma is a cancer of non-thyroid hormone-producing cells that are normally present in the thyroid gland. This ... Tumor - thyroid; Cancer - thyroid; Nodule - thyroid cancer; Papillary thyroid carcinoma; Medullary thyroid carcinoma; ... Papillary carcinoma is the most common type, and it usually affects women of childbearing age. It spreads slowly and is the ...
Basal cell carcinoma of the vulva. Mt Sinai J Med. 1978;45(3):406-10. [PubMed]. 15. Dudzinski MR, Askin FB, Fowler WC. Giant ... Basal cell carcinomas are usually misdiagnosed as Bowen disease, Paget disease, squamous cell carcinoma, leukoplakia, lichen ... Vulvar basal cell carcinoma. Dermatol Surg. 1997;23(3):207-9. [PubMed]. 29. Mizushima J, Ohara K. Basal cell carcinoma of the ... Basal cell carcinoma accounts for 1-8 percent of all vulvar carcinomas [1, 3, 5, 10, 11, 14, 16, 31, 33, 35, 38]. It affects ...
Renal cell carcinoma. *Schwannoma. *Spinal cord ependymoma. *Subependymal giant cell tumor. *Wilms tumor (bilateral only) ... Tumor type is suggestive of a specific cancer predisposition syndrome (e.g., adrenocortical carcinoma, renal cell carcinoma or ... Choroid plexus carcinoma, a type of brain tumor. *Adrenocortical carcinoma, which is present in the adrenal glands located on ... However, 20% of the time, this genetic change occurs on its own in an oocyte or sperm cell prior to fertilization. ...
Metastatic basal cell carcinoma is a rare skin cancer that has spread beyond the original tumor site. Learn more about this ... Is usually associated with large primary lesions, including "giant" basal cell carcinomas with blood vessel involvement. ... Basal cell carcinoma appears as an abnormal skin growth, bump or sore that is usually slow-growing and successfully treated ... Most often occurs in middle-aged men-in fact, men are twice as likely to develop metastatic basal cell carcinoma than women. ...
Learn in-depth information on Invasive Ductal Carcinoma of Breast (NOS), its causes, symptoms, diagnosis, complications, ... Invasive Ductal Carcinoma of Breast, Carcinoma with Osteoclastic Giant Cells. *Invasive Ductal Carcinoma of Breast, Carcinoma ... Invasive Ductal Carcinoma of Breast, Carcinoma with Melanotic Features. Who gets Invasive Ductal Carcinoma of Breast (NOS)? ( ... Stage 0 (carcinoma in situ): The abnormal cancer cells are confined to their site of origin (the breast duct linings, lobules, ...
An atypical form of hyperplasia can be mistaken for clear cell carcinoma. Unlike clear cell carcinoma, it lacks stromal ... and multinucleated Langerhans giant cells characterize the lesions. [33] ... Isolated neuroendocrine epithelial cells of argentaffin type or argyrophil type are admixed with the normal endocervical cells ... The cells lining the tubules contain no glycogen or mucin, but the center of the tubule may contain a pink material that ...
The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm, and exhibited ... These findings led to the diagnosis of neuroendocrine carcinoma of small cell type. The patient was administered adjuvant ... Histology of biopsy specimens indicated a neuroendocrine carcinoma. A computed tomography showed an esophageal tumor with ... Esophageal neuroendocrine carcinomas are rare, aggressive and have a poor prognosis. Combined therapy using chemotherapy, ...
The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. ... A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS ... The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. ... Hepatoma; Carcinoma, Hepatocellular; Hepatocellular Cancer; Liver Cancer, Adult; Liver Cell Carcinoma, Adult; Adult Liver ...
Giant cell transformation infrequent and focal * Interlobular bile duct may be hypoplastic with paucity * Fibrosis not ... Hepatocellular carcinoma and cholangiocarcinoma have been associated with PFIC3 (J Clin Exp Hepatol 2014;4:25) * Biliary ... Histology shows lobular disarray with prominent giant cell transformation of hepatocytes and inflammation * There is a risk of ... Neonatal hepatitis: giant cell transformation, lobular inflammation, hepatocyte necrosis, apoptosis and hepatocyte ballooning ...
For the giant cell form, the survival time is less than 6 months from time of diagnosis; for the small cell form, the 5-year ... Medullary carcinoma arises from the C cells and produces calcitonin. The lesion can occur as a solitary malignant tumor or as ... Virtually all tumors of the thyroid gland arise from glandular cells and are, therefore, adenomas or carcinomas. Functioning ... Follicular carcinoma may also be associated with a normal life span if it is identified before it becomes invasive, but late ...
Less common subtypes include adenosquamous carcinomas, squamous cell carcinomas, and giant cell carcinomas. ... The pancreas is comprised predominantly of exocrine cells (acini and ductal cells) and endocrine cells (islets of Langerhans). ... in high risk patients including first degree relatives of patients with genetic predisposition to pancreatic carcinoma, ...
... predominantly squamous cell carcinoma (SCC). However, the ratio between SCC and basal cell... ... in immunosuppressed patients the SCC tumours are more often characterised by the presence of multinucleated giant cells [25, 26 ... Squamous cell carcinomas in organ transplant recipients. Comparison of histopathological and clinical features of squamous cell ... "Squamous cell carcinomas in organ transplant recipients. Comparison of histopathological and clinical features of squamous cell ...
A giant sarcomatoid renal cell carcinoma. Wu, M. Y., Liaw, C. C., Chen, Y. C., Tian, Y. C., Hsueh, S., Jenq, C. C., Fang, J. T. ... Aggressive pulmonary metastasectomy for metastatic renal cell carcinoma--6 cases report. Hsu, H. S., Huang, B. S., Chen, M. T. ... A G-quadruplex stabilizer induces M-phase cell cycle arrest. Tsai, Y. C., Qi, H., Lin, C. P., Lin, R. K., Kerrigan, J. E., ... Aggressive B-cell lymphomas-from morphology to molecular pathogenesis. Chen, B-J., Fend, F., Campo, E. & Quintanilla-Martinez, ...
Informes de casos: Undifferentiated carcinoma with osteoclastic giant cells of the pancreas diagnosed by endoscopic ultrasound ...
Undifferentiated carcinoma with or without giant cells. *Pancreatic neuroendocrine tumors (PanNET)-Come from the islet cells. ... Acinar cell carcinoma-Arise from the exocrine cells that make pancreatic enzymes for digestion. There are other, more rare ... Normally, the cells divide in a controlled manner. If cells keep dividing when new cells are not needed, a tumor forms. ... The pancreas is made up of 2 types of cells. These are the endocrine and exocrine. The endocrine, or islet cells, make many ...
... adults with advanced renal cell carcinoma after failure of treatment with sunitinib or sorafenib; adults with renal ... and pediatric and adult patients with tuberous sclerosis complex who have subependymal giant cell astrocytoma that requires ... 7,029,913, which is directed to a replicating in vitro cell culture of pluripotent human embryonic stem cells derived from a ... because ISCOs cells cannot undergo such a development process. Thus, ISCO argues that these cells should be capable of being ...
  • The patient's medical history was significant for adult-onset diabetes mellitus and two basal cell carcinomas of the face that had been excised one year before. (
  • BCCs should be differentiated from adenoid cystic (basal cell) carcinomas of the vestibular glands that may behave more aggressively [ 11 ]. (
  • Fewer than 1% of basal cell carcinomas - the most common form of cancer in the United States - spread (metastasize) beyond the primary cancer site. (
  • Is usually associated with large primary lesions, including "giant" basal cell carcinomas with blood vessel involvement. (
  • Pilomatricomas, especially when not calicified, can resemble many other cutaneous tumors, such as epidermoid cysts, pilar cysts, dermoid cysts, squamous cell carcinomas, basal cell carcinomas as well as other follicular neoplasms, such as trichoepithelioma and trichoblastoma. (
  • Regional lymph node metastasis is an important prognostic factor in head and neck squamous cell carcinoma (HNSCC) and plays a decisive role in the choice of treatment. (
  • Head and neck squamous cell carcinoma is a relatively common malignancy, associated with severe disease- and treatment-related morbidity. (
  • Squamous cell carcinoma is an aggressive epithelial malignancy of the upper aerodigestive tract comprising 90% of all head-and-neck squamous cell carcinoma (HNSCC). (
  • There remains up to a 50% recurrence rate in advanced p16- head and neck squamous cell carcinoma with current standard of care treatment. (
  • To survey the landscape of active neoadjuvant immunotherapy trials in head and neck squamous cell carcinoma and summarize and synthesize currently available outcomes from these trials. (
  • Neoadjuvant immunotherapy has proven safe and well tolerated in head and neck squamous cell carcinoma with encouraging efficacy results, including relatively high rates of pathologic response. (
  • We await updated reports of disease free survival and overall survival data and results of ongoing phase III studies utilizing neoadjuvant immunotherapy to determine if this treatment paradigm will have a place in the standard of care treatment in head and neck squamous cell carcinoma. (
  • Current standard of care treatment for patients with locoregionally advanced head and neck squamous cell carcinoma (HNSCC) is either definitive chemoradiotherapy (CRT) or surgical resection followed by adjuvant radiation with the addition of radiosensitizing chemotherapy when high risk features are noted on final pathology. (
  • This is an unusual malignant thyroid neoplasm with morphologic resemblance to giant cell tumor of bone. (
  • Merkel cell carcinoma is a rare, aggressive, malignant cutaneous tumor. (
  • In rare cases, longstanding inflammation can lead to malignant transformation, most commonly to Squamous Cell Carcinoma (SCC), the treatment of choice for which is total surgical resection with free margins. (
  • It is a type of cancer in which certain cells in the breast become abnormal, grow uncontrollably, and form a malignant mass (tumor). (
  • A primary malignant neoplasm of epithelial liver cells. (
  • Anaplastic carcinoma, though rare, is the most malignant tumor of the thyroid gland and is found mainly in patients older than 60 years. (
  • The majority were nonspecific reactive hyperplasia with a polymorphic, high cell density pattern and without malignant features, followed by pyogenic tuberculous lymphadenitis. (
  • Vipomas, derived from the pancreatic ISLET CELLS, generally are malignant and can secrete other hormones. (
  • Giant fibroadenomas have a risk of malignant transformation. (
  • Less common subtypes include adenosquamous carcinomas, squamous cell carcinomas, and giant cell carcinomas. (
  • Squamous cell carcinomas in organ transplant recipients. (
  • Renczyńska-Matysko J, Marquardt-Feszler A, Dębska-Ślizień A, Imko-Walczuk B. Squamous cell carcinomas in organ transplant recipients. (
  • IMSEAR at SEARO: Anaplastic thyroid carcinoma with osteoclast-like giant cells. (
  • Valand AG, Ramraje SN, Pandeya BS, Shedge R, Aware S. Anaplastic thyroid carcinoma with osteoclast-like giant cells. (
  • A case of anaplastic thyroid carcinoma with osteoclast-like giant cells is reported. (
  • Case report: Pathological and genetic features of pancreatic undifferentiated carcinoma with osteoclast-like giant cells. (
  • We aimed to investigate the pathological and genetic characteristics of pancreatic undifferentiated carcinoma with osteoclast -like giant cells and the key points of treatment . (
  • The clinical data and follow-up results of four patients diagnosed with pancreatic undifferentiated carcinoma with osteoclast -like giant cells between May 2015 and May 2020 at the First Affiliated Hospital of Xi'an Jiaotong University were retrospectively analyzed. (
  • Tumor metastasis was found in pancreatic adipose tissue in two patients and lymph node metastasis in one patient , with microscopic heterogeneous mononuclear cells and scattered osteoclast -like giant cells of various sizes. (
  • 3 Patients with TSC have an increased incidence of tumors, such as multiple renal angiomyolipomas, renal cell carcinoma, and oncocytoma. (
  • Finally, surgery is the mainstay of treatment even in giant tumors, and in some cases, it should be followed by radiotherapy to address the risk of metastatic spread. (
  • It is now recognized that 'superficial' bladder carcinomas are a heterogenous group of tumors with diverse biological and clinical manifestations. (
  • Virtually all tumors of the thyroid gland arise from glandular cells and are, therefore, adenomas or carcinomas. (
  • Pancreatic neuroendocrine tumors (PanNET)-Come from the islet cells. (
  • In 1905, Malherbe reexamined the tumors, determined the origin to be hair matrix cells and suggested the term pilomatrixomas. (
  • The tumors are usually located in the lower dermis extending into the subcutaneous fat and composed of irregularly shaped islands of epithelial cells within a cellular stroma (Figure 2). (
  • Mutations in the beta-catenin gene, CTNNB1, are thought to be responsible for the growth of these tumors, by activating gene transcription via Wnt-TCF-Lef-1, which leads to abnormal matrical cell proliferation. (
  • [ 6 ] A majority of these tumors will exhibit polysomy of the epidermal growth factor receptor ( EGFR ) genetic locus on chromosome 7 in subsets of tumor cells. (
  • Ameloblastoma is a benign dental tumor mostly found in the mandible, with several variations El ameloblastoma es un tumor odontogénico benigno que se encuentra mayormente en la mandíbula 80%) usually found in the mandible, making up about 1% of tumors in the oral region.2 ameloblastoma . (
  • NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. (
  • Lung neuroendocrine tumors (LNETs) are a group of rare tumors with heterogenous malignancy originating in amine precursor uptake and decarboxylation (APUD) neuroendocrine cells from Kulchitsky cells (argentaffin cells) ( 1 ). (
  • Azzopardi introduced the term of oat cell carcinoma in 1959 after a study on 100 cases of pulmonary tumors ( 4 ). (
  • The neuroendocrine cells from which neuroendocrine tumors (NETs) derive are located in numerous places in the human body ( 8 ). (
  • Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. (
  • There are 4 types of carcinomas of the thyroid: papillary, follicular, medullary, and anaplastic (undifferentiated). (
  • An epithelial neoplasm characterized by unusually large anaplastic cells. (
  • He went on to have a transabdominal ultrasound, which demonstrated a 6.5-cm heterogenous mass in the left lobe of the liver with ultrasound features suggestive of hepatocellular carcinoma. (
  • The appearances were suggestive of either lymphoma or hepatocellular carcinoma. (
  • Cite this: Massive Primary Hepatic Tuberculoma Mimicking Hepatocellular Carcinoma in an Immunocompetent Host - Medscape - Jul 18, 2006. (
  • In this report, we aimed to underline the importance of early diagnosis while presenting a case of giant Merkel cell carcinoma which shows an aggressive progression with lung metastases. (
  • Follicular carcinoma may also be associated with a normal life span if it is identified before it becomes invasive, but late metastases can occur. (
  • Apocrine skin carcinoma has characteristics similar to those of cutaneous breast carcinoma metastases when it presents a tubule-lobular, or cordonal differentiation. (
  • However, when it does spread, metastatic basal cell carcinoma can reach lymph nodes, other areas of the skin or more distant sites like the lungs and bones. (
  • There is still much to learn about metastatic basal cell carcinoma and the factors that cause it to spread. (
  • Most often occurs in middle-aged men-in fact, men are twice as likely to develop metastatic basal cell carcinoma than women. (
  • When it comes to seeking treatment for complex diseases like metastatic basal cell carcinoma, the knowledge and experience of the physician you choose is paramount. (
  • If you would like to consult with a Moffitt oncologist specializing in skin cancer about your metastatic basal cell carcinoma treatment options, complete a new patient registration form online or call 1-888-663-3488 . (
  • Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (
  • The findings show the challenge in differentiating a primary tumor of the sweat gland from a metastatic cutaneous tumor of mammary carcinoma, even with the immunohistochemical resources currently available. (
  • Pancreatic undifferentiated carcinoma accounts for 2%-7% of pancreatic carcinomas . (
  • RATIONALE: Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. (
  • Screening with EUS or MRI may be indicated in high risk patients including first degree relatives of patients with genetic predisposition to pancreatic carcinoma, carriers of BRCA2 mutations, p16 mutations and patients with Lynch Syndrome with affected first degree relatives, or patients with Peutz-Jeghers syndrome. (
  • Acinar cell carcinoma-Arise from the exocrine cells that make pancreatic enzymes for digestion. (
  • No standardized follow-up modality has been established for angiomyolipomas, so patients should be placed under active surveillance, similar to that carried out in cases of renal cell carcinoma. (
  • The coexistence of renal cell carcinoma and renal angiomyolipoma within the same tumor mass, also called collision tumor, is unusual, and, to our knowledge, only 6 cases have been reported. (
  • 3 , 4 , 6 - 9 We present a case of a young male with TSC and a giant angiomyolipoma that contained a focal lesion with renal cell carcinoma. (
  • The CHMP also gave its backing for Pfizer's Inlyta (axitinib) as a treatment for advanced renal cell carcinoma after the failure of treatment with the drug giant's own Sutent (sunitinib) or with cytokines. (
  • Isolated neuroendocrine epithelial cells of argentaffin type or argyrophil type are admixed with the normal endocervical cells. (
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (
  • Protein tyrosine phosphatase, which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. (
  • Hostopathological report shows epithelial cells along with fibrous element. (
  • In addition to the lipid material, Zagarelli et al also noted the presence of what they interpreted as degenerating epithelial cells in the foam cells. (
  • A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS . (
  • Nonacinar forms of prostate cancer include other glandular PCa, the ductal adenocarcinoma and the treatment-associated neuroendocrine carcinoma, and nonglandular PCa, the adenosquamous carcinoma, the squamous cell carcinoma and the adenoid cystic (basal cell) carcinoma of the prostate. (
  • Histology of biopsy specimens indicated a neuroendocrine carcinoma. (
  • These findings led to the diagnosis of neuroendocrine carcinoma of small cell type. (
  • In 1947, Hoffman introduced the term of pulmonary tumorlet, a term that describes a form of low-grade neuroendocrine carcinoma that is capable of metastasizing to the lymph nodes ( 3 ). (
  • Microscopic pathology image showing infiltrating ductal carcinoma of breast. (
  • Invasive Ductal Carcinoma of Breast, Not Otherwise Specified (NOS) are invasive breast cancers, which have a tendency to be aggressive and spread. (
  • The signs and symptoms of Invasive Ductal Carcinoma of Breast (NOS) include lump in the breast, swelling or skin thickening around the region of the lump, and change in breast profile. (
  • The prognosis of Invasive Ductal Carcinoma of Breast (NOS) depends on the stage of the tumor and response to treatment, since it is an invasive type of malignancy. (
  • Who gets Invasive Ductal Carcinoma of Breast (NOS)? (
  • Invasive Ductal Carcinoma of Breast (NOS) is a very common type of breast cancer. (
  • What are the Risk Factors of Invasive Ductal Carcinoma of Breast (NOS)? (
  • The pancreas is comprised predominantly of exocrine cells (acini and ductal cells) and endocrine cells (islets of Langerhans). (
  • This designation includes noninvasive papillary urothelial carcinoma (pTa), carcinoma in situ (CIS) (pTis), and tumor invading into the lamina propria (pT1). (
  • Being overweight or having obesity may be a risk factor for papillary carcinoma of the thyroid. (
  • Papillary carcinoma is the most common type, and it usually affects women of childbearing age. (
  • Papillary carcinoma is the most common form of thyroid tumor. (
  • FNA diagnosis of giant cell tumour of bone presenting at unusual sites. (
  • An increase in number of mast cells - significant in making diagnosis. (
  • Anatomopathological and immunohistochemical study revealed a preliminary diagnosis of breast carcinoma metastasis. (
  • New anatomopathological and immunohistochemical exams confirmed the diagnosis of breast carcinoma metastasis. (
  • This study aimed to report and discuss the challenging differential diagnosis between a primary tumor of sweat glands and cutaneous metastasis of mammary carcinoma using anatomopathological and imaging diagnostic resources available today. (
  • The two false-negatively diagnosed cases were of the lymphocytic predominant type where no Reed-Sternberg cells were detected, making the diagnosis by cytology impossible [1]. (
  • A few S100-negative dendritic or granular cells have been reported in these lesions as well and may represent Langerhans cells. (
  • Unusual Variants Of Diffuse Large B-cell Lymphoma at Extranodal sites-Are These Distinct Diagnostic entities. (
  • The anatomopathological report indicated breast carcinoma metastasis and the pathologist recommended a further immunohistochemical investigation to determine the neoplastic site of origin. (
  • The 2022 WHO classification mentions prostatic intraepithelial neoplasia (PIN)-like carcinoma, signet-cell-like adenocarcinoma, sarcomatoid carcinoma and pleomorphic-giant-cell adenocarcinoma of the prostate as true subtypes of acinary PCa. (
  • Who are the top experts researching treatments for invasive lobular carcinoma? (
  • What are the top concepts researched in studies about invasive lobular carcinoma? (
  • What are some of the top places that specialize in invasive lobular carcinoma? (
  • of invasive lobular carcinoma on mammography and ultrasound examinations. (
  • of invasive lobular carcinoma of breast and to discuss problems that may occur in cytodiagnosis. (
  • Invasive lobular carcinoma is the second most frequent histological type of breast cancer and its incidence is increasing. (
  • Mr Imaging Of The Breast In Patients With Invasive Lobular Carcinoma. (
  • MATERIALS AND METHODS: This is a retrospective multicenter study of women with biopsy-proven invasive lobular carcinoma. (
  • Invasive Lobular Carcinoma Of The Breast: Mammographic Characteristics And. (
  • BACKGROUND: Invasive lobular carcinoma is the second most common histological type of breast carcinoma, accounting for approximately 5%-15% of all invasive breast cancers. (
  • Basal cell carcinoma (BCC), the most common human cancer, is seldom seen in the genital area. (
  • Medullary carcinoma is a cancer of non-thyroid hormone-producing cells that are normally present in the thyroid gland. (
  • Medgysey, C.D., Wolff, R.A., Putnam Jr, J.B. and Ajani, J.A. (2000) Small cell carcinoma of the esophagus: The University of Texas M.D. Anderson Cancer Center experience and literature review. (
  • Skin cancer is the most frequently described neoplasm among OTRs, whereas squamous cell carcinoma (SCC) is very often declared to be the most frequently occurring cancer among those patients. (
  • Cancer is a disease in which cells grow in an abnormal way. (
  • Cancer cells spread and cause damage around them. (
  • They're based on the cell type and where the cancer starts. (
  • The Sonic hedgehog (Hh) pathway is known to be important in basal cell carcinoma (BCC), which as an extremely common skin cancer that only rarely invades and metastasizes . (
  • To review the imaging findings of a series of cases of metaplastic carcinoma of the breast, a rare and aggressive form of breast cancer with variable imaging features. (
  • Mammographic findings were not different from the usual features of more prevalent types of breast cancer, though the majority of metaplastic carcinoma of the breast showed possible distinctive sonographic features, such as circumscribed margins or complex echogenicity, reflecting the histologic background. (
  • Basal cell carcinoma is a type of skin cancer which begins in the basal cells. (
  • Although the patient had no medical history of breast cancer, due to this result, she was referred to a mastologist, who investigated her breast nodules for the possible primary focus of the carcinoma. (
  • breast carcinoma, sweat gland carcinoma, skin cancer. (
  • Effect of 10.5 GHz CW radiofrequency radiation exposure on normal and prostate cancer cell morphology [med. (
  • Giant, exophytic and cystic versions can also occur. (
  • LAM produces cystic lung disease adroitly characterized as a type of perivascular epithelioid cell tumor. (
  • Fine needle aspiration findings were consistent with giant cell carcinoma of the lung. (
  • I'm talking about carcinoma of the lung that had already metastasized to his liver and spine. (
  • After an incisional biopsy, her sample was firstly sent for anatomopathological study in a first pathology laboratory, chosen by the dermatologist, with the diagnostic hypothesis of basal cell carcinoma. (
  • The pathology laboratory received a 0.3 cm surgical skin sample, which was microscopically described as a dermis fragment infiltrated by neoplasia consisting of small cells, hyperchromatic nuclei, grouped into small nodules, cords or outlining structures ring, dissecting the entire dermis and with preserved epidermis. (
  • After 2 years, the patient observed recurrence of the squamous cell carcinoma, but he did not seek further evaluation and treatment. (
  • Giant cell tumor at such a location is unusually aggressive and needs regular follow up to detect local recurrence. (
  • 2017) Sequencing and de novo transcriptome assembly of the Chinese giant salamander (Andrias davidianus) . (
  • Medullary carcinoma arises from the C cells and produces calcitonin. (
  • Based on these findings, the patient was diagnosed as having Merkel cell carcinoma. (
  • Donato H, Candelária I, Oliveira P, Gonçalo M, Caseiro-Alves F. Imaging Findings of Metaplastic Carcinoma of the Breast with Pathologic Correlation. (
  • Histopathology evaluation revealed an angiomyolipoma with a focal lesion and clear cell renal carcinoma within the tumor. (
  • Dermatological examination revealed a giant tumoral lesion 9x9 cm in diameter, containing crusted and ulcerated areas on her left cheek. (
  • Histopathological examination of the specimen obtained from the lesion showed a neoplastic infiltration consisting small, atypic cells with big, round, hyperchromatic nucleus, narrow cytoplasms, and prominent nucleoulus in some areas, showing high mitotic activity. (
  • Squamous cell carcinoma is the most common tumor in the hand, with actinic keratosis being its precursor lesion. (
  • Histological aspect of the lesion: basophilic nodules with peripheral palisading of cells invade the dermis. (
  • Histopathologic examination of three biopsies taken from different areas of the lesion showed a similar picture: under a thinned epithelium, a dermal tumor was found, made up of confluent nodules consisting of basophilic cells, assuming a palisaded arrangement at their periphery (Figure 2). (
  • Alshareef T, Alfriedy R, Aldhaheri R, Arab N, Badahdah F. A Giant Squamous Cell Carcinoma in a Patient with Pilonidal Sinus: A Case Report. (
  • Correlate specific in vivo parameters of immune response (post-vaccination delayed-type hypersensitivity reactions to autologous tumor, mesothelin-specific T-cell response, and the degree of local eosinophil, macrophage, and T-cell infiltration at the vaccine site) with clinical responses in patients treated with this regimen. (
  • Neither the 1973 nor the 2004 WHO grading system appears to be useful for predicting the clinical outcome of invasive urothelial carcinoma. (
  • Esophageal neuroendocrine carcinomas are rare, aggressive and have a poor prognosis. (
  • Akt was found to be overexpressed in the endothelial cells of cutaneous VMs in a murine model, which activated mTOR (24). (
  • Cutaneous verruciform xanthoma: a report of five cases investigating the etiology and nature of xanthomatous cells. (
  • The exocrine cells make digestive juices. (
  • In this type, the cancerous cells originate in the milk ducts and spread to other tissues in the breast. (
  • Clinically, breast carcinoma with OGCs can be confused with fibroadenoma. (
  • Retrospective review of multimodality imaging features of eleven cases of metaplastic carcinoma of the breast retrieved from a single hospital institution database. (
  • Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. (
  • Radiation therapy uses high-energy x-rays to damage tumor cells. (
  • Giving vaccine therapy together with chemotherapy and radiation therapy after surgery may kill any remaining tumor cells. (
  • The tumor cells were arranged in microtubular structures, with small and round cells containing scanty cytoplasm, and exhibited intense mitosis 51/10 HPF. (
  • They are named for the hormone that is produced by the tumor cells such as gastrinoma (stomach) or insulinoma (pancreas). (
  • However, 20% of the time, this genetic change occurs on its own in an oocyte or sperm cell prior to fertilization. (
  • Basal cell carcinoma is one of the most common human cancers, affecting some 2 million people a year in the US, according to the American Academy of Dermatology, and is thought to be mainly caused by exposure to ultraviolet light. (
  • Una variante rara y muy agresiva es el carcinoma basocelular gigante, que representa s lo 1% de los casos y se asocia a mal pron stico. (
  • Según estimaciones de la Organización Mundial de la Salud (OMS), en el 2015 257 millones de personas en el mundo tenían la infección crónica por el virus de la hepatitis B (VHB) y 900 000 fallecieron a causa de ella, en la mayor parte de los casos de cirrosis o carcinoma hepatocelular. (
  • Pleomorphic cells and tumour giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. (
  • The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. (