Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
A scraping, usually of the interior of a cavity or tract, for removal of new growth or other abnormal tissue, or to obtain material for tissue diagnosis. It is performed with a curet (curette), a spoon-shaped instrument designed for that purpose. (From Stedman, 25th ed & Dorland, 27th ed)
Tumors or cancer located in bone tissue or specific BONES.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
Chronic inflammation and granuloma formation around irritating foreign bodies.
A malignant epithelial tumor with a glandular organization.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the LUNG.
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
Tumors or cancer of the THYROID GLAND.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tumors or cancer of the human BREAST.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells. It occurs primarily in the epiphyses of adolescents. It is relatively rare and represents less than 2% of all primary bone tumors. The peak incidence is in the second decade of life; it is about twice as common in males as in females. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1846)
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Tumors or cancer of the ESOPHAGUS.
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Tumors or cancer of the SKIN.
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A fibro-osseous hereditary disease of the jaws. The swollen jaws and raised eyes give a cherubic appearance; multiple radiolucencies are evident upon radiographic examination.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A superorder of CEPHALOPODS comprised of squid, cuttlefish, and their relatives. Their distinguishing feature is the modification of their fourth pair of arms into tentacles, resulting in 10 limbs.
Elements of limited time intervals, contributing to particular results or situations.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
DNA present in neoplastic tissue.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Tumors or cancer of the UTERINE CERVIX.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Histiocytic, inflammatory response to a foreign body. It consists of modified macrophages with multinucleated giant cells, in this case foreign-body giant cells (GIANT CELLS, FOREIGN-BODY), usually surrounded by lymphocytes.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Antibodies produced by a single clone of cells.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
A benign tumor composed, wholly or in part, of cells with the morphologic characteristics of HISTIOCYTES and with various fibroblastic components. Fibrous histiocytomas can occur anywhere in the body. When they occur in the skin, they are called dermatofibromas or sclerosing hemangiomas. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 5th ed, p1747)
Tumors or cancer of the MANDIBLE.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A superfamily of nematodes whose members are free-living saprophytes or parasites of plants. Ova are sometimes found in human feces after ingestion of infected plants.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
Outgrowths of synovial membrane composed of villi and fibrous nodules characterized histologically by hemosiderin- and lipid-containing macrophages and multinucleated giant cells. It usually occurs in the knee.
RNA present in neoplastic tissue.
Tumors or cancer located in muscle tissue or specific muscles. They are differentiated from NEOPLASMS, MUSCLE TISSUE which are neoplasms composed of skeletal, cardiac, or smooth muscle tissue, such as MYOSARCOMA or LEIOMYOMA.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
A polypeptide hormone of approximately 25 kDa that is produced by the SYNCYTIOTROPHOBLASTS of the PLACENTA, also known as chorionic somatomammotropin. It has both GROWTH HORMONE and PROLACTIN activities on growth, lactation, and luteal steroid production. In women, placental lactogen secretion begins soon after implantation and increases to 1 g or more a day in late pregnancy. Placental lactogen is also an insulin antagonist.
Transplantation between animals of different species.
An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Measurement of rate of settling of erythrocytes in anticoagulated blood.
Tumors or cancer of the BRONCHI.
The grafting of bone from a donor site to a recipient site.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Established cell cultures that have the potential to propagate indefinitely.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Five fused VERTEBRAE forming a triangle-shaped structure at the back of the PELVIS. It articulates superiorly with the LUMBAR VERTEBRAE, inferiorly with the COCCYX, and anteriorly with the ILIUM of the PELVIS. The sacrum strengthens and stabilizes the PELVIS.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Neoplasms of the bony part of the skull.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Study on the metastatic mechanisms of human giant-cell lung carcinoma comparison between the strains C and D. (1/25)

The biologic characteristics of the two human giant-cell lung carcinoma strains with high (strain D) and low metastatic potential (strain C) were studied, including karyotype of chromosome, intracellular free calcium ([Ca2+]i), morphologic changes of cell surface and the expression of nm23-H1, p53, ras, c-myc, c-erbB2, bcl-2 genes and PCNA. The correlation between different biologic features and the metastatic potential of the two strains was analyzed. We found: 1) Both strains had the karyotypic abnormality of -13, -14, -15, +20, +21 with seven same marker chromosomes. Only strain D had the karyotypic abnormality of +7, -17, -18, +X, 7p+; 2) [Ca2+]i of the strain C (984.7 +/- 573.8) and D (517.6 +/- 216.6) was significantly different (p < 0.05). The amplitude of intracellular calcium oscillations of strain C was lower than the one of strain D; 3) strain C had more villous-like protrusions on the cell surface, whereas strain D had more bubble-like protrusions; 4) The expression of nm23-H1 and p53 protein of strain C was all higher than that of strain D. The expression of PCNA of strain C was lower than strain D; 5) nm23-H1 mRNA levels of strain C was lower than that of strain D. We consider that the karyotype of chromosomes, intracellular free calcium, the structure of cell membrane and the expression of nm23-H1 gene, p53 gene, PCNA could be closely related to the metastatic potential of human giant-cell lung carcinoma. They could be used as the sign for judging whether the tumor will metastasize in clinical practice as well as in judging the prognoses of patients.  (+info)

Effect of interleukin-6 on the growth of human lung cancer cell line. (2/25)

OBJECTIVE: To investigate the effect of interleukin-6 (IL-6) on the growth of human lung cancer in vivo as well as in vitro. METHODS: To examine the mRNA level of IL-6 receptor (IL-6R) in high-metastatic human lung giant cell carcinoma cell line PG by means of reverse transcription polymerase chain reaction (RT-PCR). To assess the existence of IL-6 receptor complex (including IL-6R and gp130) with the treatment of PG cells by use of recombinant human IL-6 (rhIL-6), recombinant human oncostatin M (rhOSM), and recombinant human leukemia inhibitory factor (rhLIF), respectively. To detect the expression of IL-6 by Northern blotting hybridization and bioactive assay. To identify the effect of IL-6 secreted by PG cells by use of IL-6 and IL-6R antisense oligodeoxynucleotides (ODNs), and specific neutralizing antibody to IL-6. To document the influence of IL-6 on PG cells growth in vivo through the strategy of the transfection of expression vector inserted antisense IL-6 cDNA. RESULTS: RT-PCR analysis revealed that PG cells expressed IL-6R mRNA. Any one of the recombinant cytokine IL-6, OSM and LIF stimulated the growth of PG cells in vitro in a concentration-dependent manner. These results demonstrated IL-6 receptor complex exist in PG cells. At the same time, PG cells expressed IL-6 mRNA and secreted bioactive IL-6. Both IL-6 antisense ODNs and IL-6R ODNs inhibited PG cells proliferation. Treatment of PG cells with IL-6 antibodies reduced the growth of PG cells in vitro. PG cells transfected with IL-6 antisense expression vector showed a decreased growth in nude mice. CONCLUSION: IL-6 functions as an autocrine growth stimulator for PG cells in vivo as well as in vitro.  (+info)

Pleomorphic carcinoma: report of a case with massive pleural effusion and asbestos particles. (3/25)

Pleomorphic (spindle/giant cell) carcinoma (PC) is one subset of large cell carcinoma. It is well known that PC patients have a poor survival rate. This report describes a 68-year-old man with PC. The patient's tumor had a massive pleural effusion. A left lower lobectomy and partial resection of the left diaphragm, peritoneum, and parietal pleura were performed to remove the tumor. Numerous asbestos particles were found in the left lower lobe. This is the first reported case of PC which may have been caused by asbestos particles. Further investigation is needed into whether asbestos exposure causes PC.  (+info)

Effective asymmetry in gap junctional intercellular communication between populations of human normal lung fibroblasts and lung carcinoma cells. (4/25)

The dysfunction of homologous and/or heterologous gap junctional intercellular communication (GJIC) has been implicated in tumorigenesis of many kinds of cells. Here we have characterized GJIC and the expression of connexins in six human lung carcinoma cell lines and normal lung fibroblasts (HLF). Compared with HLF, all the carcinoma cells showed reduced or little homologous GJIC. They expressed remarkably reduced connexin(Cx)43 mRNA and variable levels of Cx45 mRNA, but neither Cx43 nor Cx45 protein could be detected. However, using a preloading assay, transfer of calcein was observed between donor HLF cells and first order neighboring recipient tumor cells (recipient cells in 1000-fold excess). Transfer from tumor to HLF cells under the same conditions was not seen, although increasing the ratio of donor tumor cells to recipient HLF cells and plating the cells at low density did reveal weak transfer from tumor cells to HLF. Transfection of Cx43 into giant cell carcinoma PG cells increased homologous communication and eliminated the rectifying behavior of heterologous communication. This indicates that the apparent rectification of dye transfer between normal and tumor cells was a product of low rates of heterologous transfer linked to (i) rapid dilution of the dye to below detectable limits through a very well coupled cell population (tumor to HLF) and (ii) concentration of dye in immediate neighbors in a poorly coupled cell population (HLF to tumor cells). These results suggest that the coupling levels may need to exceed a certain threshold to allow propagation of signals over a sufficient distance to affect behavior of a cell population. We propose that the relative rates of heterologous and homologous coupling of cell populations and the 'pool size' of shared metabolites in tumor cells and the surrounding normal tissue are likely to be very important in the regulation of their growth.  (+info)

Clinicopathological features of giant cell carcinoma of the pancreas. (5/25)

BACKGROUND: Giant cell carcinoma of the pancreas (GCCP) as a tumor of high malignancy, large size, and inflammatory reaction occupies 2.1%-12.8% of all cases of pancreatic malignancies. This study was to analyze cases of GCCP collected in 8 years at our hospital in an attempt to describe some features of GCCP in Chinese people. METHODS: The clinicopathological features of 19 patients who had been pathologically diagnosed as having GCCP from 1021 patients with pancreatic malignancies collected by Pancreatic Disease Research Group (PDRG) of Changhai Hospital were retrospectively analyzed compared with those of 96 patients with common pancreatic carcinoma (PC) who were randomly selected from 1002 patients with pancreatic carcinoma. The differences of location, clinical symptoms, imagings, laboratory test, operation and the prognosis of these two groups were defined. RESULTS: Tumors in the head of the pancreas were found in 8 patients (42.1%), and those in the body or tail of the pancreas in 11 (57.9%). The initial symptom was abdominal pain in most patients (57.9%). Abdominal pain (73.7%), dyspepsia (63.2%), weight loss (36.8%) but jaundice were common at the time of diagnosis. The abnormal rates of routine laboratory tests in the GCCP group were lower than those in the common PC group. The assay of tumor markers between the groups of GCCP and common PC was approximately the same. The sensitivity and accuracy of ultrasonography, spiral computed tomography and magnetic resonance imaging were considerably high. Large carcinoma in stage IV was seen in 9 patients or 47.4% of the GCCP group, a rate higher than that in the common PC group. Osteoid formation was found microscopically in some patients, and poorly differentiated tumor cells were found in most patients. The 1-year survival rate was 17.6%, which was lower than that in the common PC group. CONCLUSION: The clinicopathological features of GCCP are different from those of common PC. Imaging tests can be used together with the assay of tumor markers to diagnose GCCP as early as possible and to improve the prognosis of GCCP patients.  (+info)

Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. (6/25)

AIM: To analyze the structure and expressions of the protein encoded by an HCC-associated novel gene, lysosome-associated protein transmembrane 4 beta (LAPTM4B). METHODS: Primary structure and fundamental characteristics of LAPTM4B protein were analysed with bioinformatics. Expressions of LAPTM4B in HCC tissues and various cell lines were detected using polyclonal antibodies and Western blot. RESULTS: LAPTM4B encoded two isoforms of proteins with molecular masses 35-ku and 24-ku, respectively. The expression level of LAPTM4B-35 protein in HCC tissues was dramatically upregulated and related to the differentiation status of HCC tissues, and it was also high in some cancer cell lines. Computer analysis showed LAPTM4B was an integral membrane protein with four transmembrane domains. LAPTM4B showed relatively high homology to LAPTM4A and LAPTM5 in various species. CONCLUSION: LAPTM4B gene encoded two isoforms of tetratransmembrane proteins, LAPTM4B-35 and LAPTM4B-24. The expression of LAPTM4B-35 protein is upregulated and associated with poor differentiation in human HCC tissues, and also at high levels in some cancer cell lines. LAPTM4B is an original and conserved protein.  (+info)

Combined osteoclastic giant cell and pleomorphic giant cell tumor of the pancreas: a rarity. An immunohistochemical analysis and review of the literature. (7/25)

CONTEXT: The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome. The origin of these two components within a tumor has long been debated based on the immunohistochemical and ultra-structural analysis. CASE REPORT: Herein we describe a tumor with amalgamation of these two distinct histomorphologies along with a minute focus of well-differentiated ductal adenocarcinoma (on multiple sections) in a 50-year male. On immunohistochemical analysis, osteoclastic giant cells were reactive for CD68 and vimentin confirming histiocytic/mesenchymal derivation whereas pleomorphic giant cells and mononuclear cells were reactive for cytokeratin which proved their epithelial nature. CONCLUSIONS: Although the present case had an equal proportion of both components, it is very important to correctly assess the predominant histology since osteoclastic giant cell tumor has a better prognosis as compared to the more aggressive pleomorphic giant cell carcinoma component.  (+info)

Aggressive giant cell tumour of bone. (8/25)

INTRODUCTION: The surgical treatment of Stage III or aggressive giant cell tumour of the bone, whether to perform intralesional or en-bloc resection, remains controversial. The aim of this study is to identify the effectiveness of en-bloc resection for local control and final oncological outcome of the disease. METHODS: The data of 20 consecutive patients with Stage III giant cell tumour were retrospectively reviewed to determine the local control and oncological outcome after treatment with wide resection. RESULTS: The majority of the patients presented late with mean duration of symptoms of 24 months, and four patients presented with recurrences. All patients were treated with wide resection except for two patients who underwent ablative surgery due to major neurovascular involvement. Ten patients required free vascularised tissue transfer to cover massive soft tissue defect. Local recurrence occurred in one patient who was again treated with wide resection and vascularised flap. Six patients had pulmonary metastases. Two patients with resectable disease were treated with thoracoscopic surgery and they remained disease-free 36 months after surgery. Two patients with multiple lung metastases were treated with chemotherapy and the disease remained non-progressive. The remaining two patients who refused chemotherapy showed radiological progression, and one succumbed to the disease with massive haemoptysis. CONCLUSION: Aggressive giant cell tumour of bone should be treated with wide resection for better local control, and treatment of pulmonary metastases is mandatory for overall prognosis.  (+info)

TY - JOUR. T1 - A case of anaplastic ductal carcinoma (giant cell carcinoma of osteoclastoid type) with portal vein and main pancreatic ductal invasion. AU - Isaka, Toshifumi. AU - Mizuno, Nobumasa. AU - Takahashi, Kuniyuki. AU - Sawaki, Akira. AU - Nakamura, Tsuneya. AU - Tajika, Masahiro. AU - Kawai, Hiroki. AU - Imaoka, Hiroshi. AU - Okamoto, Yasuyuki. AU - Inoue, Hiroyuki. AU - Aoki, Masatoshi. AU - Shimizu, Yasuhiro. AU - Yatabe, Yasushi. AU - Yamao, Kenji. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2005/6. Y1 - 2005/6. UR - UR - M3 - Article. C2 - 15981633. AN - SCOPUS:21044440650. VL - 102. SP - 736. EP - 740. JO - Japanese Journal of Gastroenterology. JF - Japanese Journal of Gastroenterology. SN - 0446-6586. IS - 6. ER - ...
Definition of giant cell carcinoma of thyroid gland. Provided by Stedmans medical dictionary and Includes medical terms and definitions.
Background: Undiffrentiated pleomorphic sarcoma of vulva with osteoclastic giant cells is a diagnosis of exclusion. It is an exceptionally uncommon diagnostic finding which was eventually diagnosed in our institute and this required a methodical clinical approach and extensive immunohistochemical markers to rule out other probable diagnostic possibilities at this site. The quick diagnostic approach at our institute was ensued by operation. Case Report: 53 years old female presented with vulval growth to our institute. Incision biopsy was performed as a routine procedure. Biopsy showed atypical spindle cells with few cells showing rhabdoid morphology and osteoclast like giant cells were also present. Histological findings with aid of immunohistochemistry led to the diagnosis of undifferentiated pleomorphic sarcoma with osteoclast like giant cells. The tumor cells stained intensely for vimentin (a mesenchymal marker), but no immunoreactivity for the Cytokeratin Pan (epithelial cells marker), ...
UCOCGC; poorly differentiated carcinoma with osteoclastic giant cells Images Poorly differentiated carcinoma with osteoclast-like giant cells (...)
INTRODUCTION: Pulmonary Sarcomatoid Carcinoma (PSC) is a rare group of tumors accounting for about 0.4% of non-small cell lung carcinoma (NSCLC). Five subtypes were described: pleomorphic carcinoma, spindle cell carcinoma, carcinosarcoma, giant cell carcinoma and pulmonary blastoma. The diagnosis is pathological but requires a good quality sampling of the tumor.. METHODS: On a series of 1582 patients operated on for lung cancer from 1992 to 2016, 43 patients were retrospectively identified as having been treated surgically for pulmonary sarcomatoid carcinoma.. RESULTS: The population consisted of 33 males and 10 females with mean age of 55 years. Imaging findings showed a peripheral mass in the majority of cases (n=29). Careful investigation failed to discover a primitive lesion elsewhere. Six patients received induction therapy for wall involvement. Lobectomy or bilobectomy was performed in 30 patients and pneumonectomy in 11 patients. A wedge resection was performed in one patient and an ...
The mean age of patients was 56.8 years (range, 46-73 years). The CT appearance of the tumor was similar for all our patients: Large mass, peripheral, heterogeneous density, with massive necrotic tissue component that strongly heightened after contrast injection; tumor had a locoregional extension with parietal and bone invasion (n = 5) and a distance extension (n = 4) to the adrenal glands. Pathological examination found a pleomorphic carcinoma (n = 3), a giant cell carcinoma (n = 1) and a carcinosarcoma (n = 2). Sarcomatoid carcinoma diagnosis was increased for the remaining patients without precision of histological subtype. ...
It has been reported that at the onset of pupariation there is an increase of lipid droplets in PG cells that can be seen by Oil Red O staining of precisely staged 120 h AEL wandering larvae (Talamillo et al., 2013). At 120 h AEL, phm,CTCFRNAi PGs had a reduced content of lipid droplets in comparison to controls (Fig. 4B, compare middle and left panels), likely due to developmental delay. However, there is also an increase of lipid droplets at the end of larval development in phm,CTCFRNAi PG cells which tend to be slightly higher than in control animals (Fig. 4B, compare right and left panels and supplementary material Fig. S4). Since the subcellular lipid accumulation phenotype of phm,CTCFRNAi PG cells is similar to that of Niemann-Pick type C (npc) mutants (Huang et al., 2005), we analyzed dnpc1a transcriptional levels but we found no changes between control and phm,CTCFRNAi larvae (data not shown). Increased lipid accumulation in the fat body in EcR knockdown larvae has been reported ...
We also analyzed the latency and jitter (the SD of the latency) of responses to ON stimulation. Across the entire GAD65+ PG cell population latencies ranged from 1.8 to 8.2 ms (mean: 3.61 ± 0.22 ms; Fig. 3D) and jitter ranged from 30 to 2,616 μs (mean: 470 ± 70 μs; Fig. 3E). However, cells with spontaneous and ON-evoked single EPSCs had significantly lower latency (2.63 ± 0.06 ms, range: 1.79-4.08 ms) and jitter (173 ± 9 μs, range: 31-298 μs) than cells with spontaneous and ON-evoked EPSC bursts (latency: 4.62 ± 0.3 ms, P , 0.000001, range: 2.16-8.20 ms; jitter 774 ± 119 μs, P , 0.000001; range: 309-2,616 μs).. ET cells provide monosynaptic burst input to ∼70% of PG cells (Hayar et al. 2004b). Thus the burst-sEPSC PG cell responses to ON input may derive from the disynaptic, ON→ET→PG circuit. However, mitral/tufted (M/T) cells could also contribute to this burst response: Back propagation of action potentials initiated near the M/T cell soma into the apical dendrites might ...
CBC Normal Adult Values WBC 5,000 - 10,000/mm3 RBC 4.5 - 5.5 million/mm3 (4 - 5 females) Hgb 14 - 17 g/dl (12 - 16 females) Hct 42 - 52% (36 - 48 females) MCV 84 - 96 fL MCH 28 - 34 pg/cell MCHC 32 - 36 g/dl Platelets 140,000 - 400,000/mm3 RDW 11.5 - 14.5% MPV 7.4 - 10.4 fL
A rare case of aneurysmal bone cyst (ABC) located in the mandibular condyle in a 10-year-old boy is presented. The patient came to our attention for a sudden swelling in the right temporomandibular region, the mouth opening was not reduced. A rapid growing mass, depicting soft tissue invasion, in the right condyle of the mandible was found. Clinically and radiographically it resembled to a malignant lesion. The surgical excision of the mandibular condyle allowed a complete removal of the lesion. The histological examination revealed a pseudocystic expanding osteolytic lesion containing blood-filled space separated by connective tissue and many osteoclastic giant cells, which was a conventional vascular ABC. The ABC is an infrequent bone lesion which can only be found very rarely at the craniofacial skeleton. There have been described about 160 cases of ABC originated in the molar region or in upper maxilla and even more rare is the location of this cyst in the mandibular condyle. Only 6 cases were
Supplementary Materialstoxins-12-00196-s001. resembling a natural cyanobacteria bloom. The estimated amount of toxins made by and were 0 respectively.023 pg/cell of microcystin-LR (MC-LR) and 7.854 pg/cell of cylindrospermopsin (CYN). After 15 times of contact with blended and one cyanobacteria, a depuration stage followed, where mussels had been fed only nontoxic microalga and modulate their cleansing and oxidative-stress protection systems after contact with MCs [23,24]. Certainly, contaminants of estuarine and seaside areas produced from the movement of polluted freshwaters from inland to the ocean have already been reported in various geographical locations [25,26,27], constituting a potential thread to sea ecosystems. For instance, high degrees of MCs had been within mussels gathered from SAN FRANCISCO BAY AREA Bay, California [26]. Furthermore, a monitoring research within this estuary demonstrated the fact that contaminants of bivalves with MCs is certainly recurrent being discovered in ...
NGC 6940 is an open cluster in the constellation Vulpecula. It was discovered by William Herschel in 1784. The cluster is nearly a billion years old and it is located 2,500 light years away. It is considered the finest open cluster in the constellation. It is located a bit more than two degrees south-southeast of 41 Cygni and three and a half degrees southwest from 52 Cygni. The cluster is bright enough to be seen even with small binoculars, which can partially resolve it. NGC 6940 is included in the Herschel 400 Catalogue. NGC 6940 has hundreds of members. The cluster is quite scattered and in between its members are also visible field stars. For example, two bright stars, a 8.6 mag B8III giant star at the NE edge and a 9.1 mag A0III giant at the SW corner of the cluster are too young to be true members of NGC 6940 and are probably background stars. The brightest star (lucida) of NGC 6940 is the red giant VG Vulpeculae, a semiregular variable star whose magnitude ranges from 9.0 to 9.5 every 80 ...
Parent of origin imprints on the genome have been implicated in the regulation of neural cell type differentiation. The ability of human parthenogenetic (PG) embryonic stem cells (hpESCs) to undergo neural lineage and cell type-specific differentiation is undefined. We determined the potential of hpESCs to differentiate into various neural subtypes. Concurrently, we examined DNA methylation and expression status of imprinted genes. Under culture conditions promoting neural differentiation, hpESC-derived neural stem cells (hpNSCs) gave rise to glia and neuron-like cells that expressed subtype-specific markers and generated action potentials. Analysis of imprinting in hpESCs and in hpNSCs revealed that maternal-specific gene expression patterns and imprinting marks were generally maintained in PG cells upon differentiation. Our results demonstrate that despite the lack of a paternal genome, hpESCs generate proliferating NSCs that are capable of differentiation into physiologically functional ...
Factor VIII has a domain organization A1-A2-B-A3-C1-C2 and synthesized as single-chain polypeptide of 2351 amino acids, from which you cut the signal peptide of 19 amino acids during translocation into the lumen of the endoplasmic reticulum. Due to the fact that factor VIII is bad glycosylases, it was difficult to achieve a high expression level (,0.2 PG/cell/day) factor VIII (Lind et al., 1995, Eur J Biochem. 232: 19-27; Kaufman et al., 1989, Mol Cell Biol. 9: 1233-1242). Expression of factor VIII in mammalian cells usually 2-3 orders of magnitude lower than the expression of other genes using similar vectors and techniques. The productivity of cell lines to obtain factor VIII is in the range of 0.5-1 MCED/KL/d (0.1-0.2 PG/CL/d).. It was shown that the B-domain of factor VIII is irrelevant to protagonizada activity. Different groups reported improvement in the expression of factor VIII in mammalian cells using truncated variants of factor VIII (Lind et al., 1995, Eur J Biochem 232: 19-27; ...
Read chapter 5 of Hematology in Clinical Practice, 5e online now, exclusively on AccessBiomedical Science. AccessBiomedical Science is a subscription-based resource from McGraw Hill that features trusted medical content from the best minds in medicine.
Mouden C, de Tayrac M, Dubourg C, Rose S, Carré W, Hamdi-Rozé H, Akloul L, Héron B, Odent S, Dupé V, Giet R, David V. PLoS One. 2015 Feb.. Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates. Godard BG, Coolen M, Le Panse S, Gombault A, Ferreiro-Galve S, Laguerre L, Lagadec R, Wincker P, Poulain J, Da Silva C, Kuraku S, Carre W, Boutet A, Mazan S. Biol. Open. 2014 Oct.. Bacterial protein signals are associated with Crohns disease. Juste C, Kreil DP, Beauvallet C, Guillot A, Vaca S, Carapito C, Mondot S, Sykacek P, Sokol H, Blon F, Lepercq P, Levenez F, Valot B, Carré W, Loux V, Pons N, David O, Schaeffer B, Lepage P, Martin P, Monnet V, Seksik P, Beaugerie L, Ehrlich SD, Gibrat JF, Van Dorsselaer A, Doré J. Gut. 2014 Oct.. Dietary intervention impact on gut microbial gene richness. Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, Almeida M, Quinquis B, Levenez F, Galleron N, Gougis S, Rizkalla S, Batto ...
A giant cell tumor is one that is made up of a large number of benign (noncancerous) cells that form an aggressive tumor, usually near the end of the bone near a joint. The location of a giant cell tumor is often in the knee, but can also involve the bones of the arms and the legs, or the flat bones such as the sternum (breastbone) or pelvis.. Giant cell tumors most often occur in young adults when skeletal bone growth is complete. Most occur in the long bones of the legs and arms.. ...
Giant cell tumor of bone is a rare, fast-growing noncancer tumor. It often grows near a joint at the end of a bone. Read on to learn about symptoms, diagnosis, and treatment.
Giant Cell Tumor A giant cell tumor is one that is made up of a large number of benign (noncancerous) cells that form an aggressive tumor. It usually develops near a joint at the end of the bone. The location of a giant cell tumor is often in the knee, .... ...
Health and wellness is a very popular topic. There are numbers of businesses, books, movies and websites dedicated to the topic. Each doctor or wellness expert has their own research and opinions on how to achieve optimum health which can be overwhelming. Good health doesnt have to mean expensive treatments and supplements, it can be…
Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. Its histogenesis remains unclear. It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with homogenous distribution. There is no widely held consensus regarding the ideal treatment method selection. There are advocates of varying surgical techniques ranging from intra-lesional curettage to wide resection. As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional approach that preserves anatomy of bone in lieu of resection. Although GCT is classified as a benign lesion, few patients develop progressive lung metastases with poor outcomes. Treatment is mainly surgical. Options of
TY - JOUR. T1 - In situ cell cycle analysis in giant cell tumor of bone reveals patients with elevated risk of reduced progression-free survival. AU - Mate, Maros E.. AU - Sven, Schnaidt. AU - Peter, Balla. AU - Zoltan, Kelemen. AU - Zoltan, Sapi. AU - Szendrői, M.. AU - Tamas, Laszlo. AU - Ramses, Forsyth. AU - Piero, Picci. AU - Krenács, T.. PY - 2019/10/1. Y1 - 2019/10/1. N2 - Objective: Giant cell tumor of bone (GCTB) is a frequently recurring locally aggressive osteolytic lesion, where pathological osteoclastogenesis and bone destruction are driven by neoplastic stromal cells. Here, we studied if cell cycle fractions within the mononuclear cell compartment of GCTB can predict its progression-free survival (PFS). Methods: 154 cases (100 primaries and 54 recurrent) from 139 patients of 40 progression events, was studied using tissue microarrays. Ploidy and in situ cell cycle progression related proteins including Ki67 and those linked with replication licensing (mcm2), G1-phase (cyclin D1, ...
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Pat Shurmur cant say it. At least not as directly as he might like to. It would go against his rule of making excuses, and given the dilapidated conditions the Giants currently reside in with a 2-8 r
TY - JOUR. T1 - Techniques in the management of juxta-articular aggressive and recurrent giant cell tumors around the knee. AU - Vidyadhara, S.. AU - Rao, S. K.. PY - 2007/3. Y1 - 2007/3. N2 - Aim: Juxta-articular aggressive and recurrent giant cell tumors around the knee pose difficulties in management. This article reviews current problems and options in the management of these giant cell tumors. Methods: A systematic search was performed on juxta-articular aggressive and recurrent giant cell tumor. Additional information was retrieved from hand searching the literature and from relevant congress proceedings. We addressed the following issues: general consensus on early diagnosis and techniques in its management. In particular, we describe our results with resection arthrodesis performed combining the benefits of both interlocking intramedullary nail and Ilizarov fixator in the management of these tumors around the knee. Results: Mean operative age of the 22 patients undergoing resection ...
From UniProt:. Porokeratosis 8, disseminated superficial actinic type (POROK8): A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Disseminated superficial actinic porokeratosis (DSAP) is the most common subtype. It is characterized by multiple small, annular, anhidrotic, keratotic lesions that are located predominantly on sun-exposed areas of the skin, such as the face, neck, and distal limbs. The lesions typically begin to develop in adolescence and reach near-complete penetrance by the third or fourth decade of life. ...
Cooper and Travers first described giant cell tumor (GCT) of bone in 1818. GCTs of bone have been described as the most challenging benign bone tumors.
Vittoria Espeli* and Cristina Mangas-A Case of Eruptive Disseminated Porokeratosis in a Cancer Patient after Trastuzumab and Exemestane Treatment: Cancer Related or Drug Induced Phenomenon?
(HealthDay)-Xgeva (denosumab) has been approved by the U.S. Food and Drug Administration to treat giant cell tumor of the bone (GCTB), a rare tumor thats most often non-cancerous.
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TY - JOUR. T1 - Topical cholesterol/lovastatin for the treatment of porokeratosis. T2 - A pathogenesis-directed therapy. AU - Atzmony, Lihi. AU - Lim, Young H.. AU - Hamilton, Claire. AU - Leventhal, Jonathan S.. AU - Wagner, Annette. AU - Paller, Amy S.. AU - Choate, Keith A.. PY - 2020/1. Y1 - 2020/1. N2 - Background: Porokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. We hypothesized that topical therapy that aims to replenish cholesterol, an essential mevalonate pathway end-product, and block the accumulation of mevalonate pathway toxic metabolites could alleviate porokeratosis. Objective: To study the efficacy of topical cholesterol/lovastatin in different variants of porokeratosis. Methods: We enrolled a series of 5 porokeratosis patients,1 with disseminated superficial actinic porokeratosis, 2 with porokeratosis palmaris et plantaris disseminata, and 2 with linear porokeratosis. Patients were genotyped before ...
Giant cell tumors of the bone are uncommon bone tumors which represent around 4-5% of primary bone tumors and 18% of all benign bone lesions. They are interesting in the fact that their classic radiographic appearance is easily identifiable. Giant cell tumors can either be benign or malignant, although the majority of them are benign. Radiographically, benign versus malignant tumors are difficult to distinguish. In most patients, the tumor has an indolent course, but repeated local recurrence of the tumor does happen. Approximately 5% of giant cell tumors are defined as malignant. Malignancy usually occurs as the result of malignant transformation after radiation therapy. These tumors are slightly more common in females, with 50-57% of cases occurring in females. The general age range for giant cell tumors is 20-40 years old. Approximately 85% of tumors occur in the long bones, namely the distal femur, proximal tibia, proximal humerus, and distal radius. Another location typical of giant cell ...
Understanding Giant cell tumor (GCT) of bone has been described as the most challenging benign bone tumors. The majority of these tumors, classically, are involved in the epiphysis of long bones. Although this disorder is benign, GCTs show a tendency of bone destruction, local recurrence and, occasionally, pulmonary metastasis. But axillary lymohnode metastasis is very very rare. Herein, we present an extremely rare case of axillary mets even after below elbow amputation in a case of recurrent giant cell tumor in a 45 yers male residing at Kolkat,.West Bengal. We treat him by radical axillary lumph node dissection.Lymph node histopatho;ogical report shows Tartrate-resistant acid phosphatase (TRAP) activity.. ...
Definition of porokeratosis - Originally (more fully porokeratosis of Mibelli): an inherited (autosomal dominant) disorder of the skin characterized by the pr
"Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: report of a case with osteochondroid differentiation". ... giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance ... However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can ... O'Reilly D, Greaves DR (September 2007). "Cell-type-specific expression of the human CD68 gene is associated with changes in ...
Anaplasia Cell growth Cytopathology Giant cell carcinoma of the lung Nuclear atypia Schmoller, Kurt M.; Skotheim, Jan M. ( ... Certain benign cell types may also exhibit pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. A rare type of ... December 2015). "The Biosynthetic Basis of Cell Size Control". Trends Cell Biol. 25 (12): 793-802. doi:10.1016/j.tcb.2015.10. ... Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and ...
Giant Cell Tumor of Hyperparathyroidism)". University of Pittsburgh School of Medicine. Retrieved 2008-11-17. Delmez, James ( ... Parathyroid carcinoma Parathyroid carcinoma (cancer of the parathyroid gland) is the rarest cause of OFC, accounting for about ... These cells are characteristically benign, feature a dense, granular cytoplasm, and a nucleus that tends to be ovular in shape ... Parathyroid carcinoma accounts for less than 1% of all cases, occurring most frequently in individuals around 50 years of age ( ...
One study compared the enzymes of liver metastases of giant-cell lung carcinoma and nonmalignant placental cells. The two were ... embryonic stem cells or embryonal carcinoma cells). There is a positive correlation between serum bone alkaline phosphatase (B- ... "Appendix E: Stem Cell Markers". Stem Cell Information. National Institutes of Health, U.S. Department of Health and Human ... Leukocyte alkaline phosphatase (LAP) is found within mature white blood cells. White blood cell levels of LAP can help in the ...
Syncytiotrophoblast giant cells also occur in polyembryomas. Primary ovarian squamous cell carcinomas are rare and have a poor ... Clear-cell adenocarcinomas are histopathologically similar to other clear cell carcinomas, with clear cells and hobnail cells. ... The most common malignancy is squamous cell carcinoma, but adenocarcinoma, basal-cell carcinoma, carcinoid tumor, ... it must have Brenner tumor foci and transitional cell carcinoma. The transitional cell carcinoma component is typically poorly ...
... analysis of the fate of giant cells produced by X-irradiating EJ30 human bladder carcinoma cells". Radiation Research. 159 (6 ... Cells that do not immediately die are likely to create aneuploid cells following subsequent attempts at cell division posing a ... Mitotic catastrophe is unrelated to programmed cell death or apoptosis and is observed in cells lacking functional apoptotic ... Mitotic catastrophe is the primary mechanism underlying reproductive cell death in cancer cells treated with ionizing radiation ...
The phrase giant cell is also frequently used, especially with carcinoma. Giant cell tumors include giant-cell tumor of bone ... Overview at Mayo Clinic Large Cell and Giant Cell Carcinoma,+Giant+Cell at the US National Library of Medicine Medical Subject ... and giant-cell tumor of the tendon sheath. Medicine portal Anaplastic large-cell lymphoma Buttock cell Nosology Giant+Cell+ ... Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are ...
There are many tumors in the differential diagnosis, including spindle cell melanoma, spindle cell squamous cell carcinoma, ... Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical ... tumour cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged ... Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing. ...
... oral squamous cell carcinoma) as well. It was shown that OSCC cells had a suppressed response to DPT. DPT expression had an ... is a biomarker for giant-cell tumor of bone (GCTB).[unreliable medical source] There is also a relationship between CCW ( ... Cell adhesion is the effect of the cell behavior due to the function of the dermatopontin. Even though, cell adhesion activity ... These connections also facilitate cell-to-cell communication (1). Dermatopontin mediates adhesion by cell surface integrin ...
Characteristic for granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes around lobules. Often ... Because it is so rare it may be sometimes confused with comedo carcinoma of the breast although the conditions appear to be ... ISBN 978-0-397-51624-7. Liong, Yee; Hong, Ga; Teo, Jennifer Gek; Lim, Geok (2013). "Breast ductal carcinoma in situ presenting ...
... giant cell fibroblastoma, granulocytic sarcoma, Kaposi's sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant ... and papillary thyroid carcinoma. A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ...
In a recent study of patients with Renal cell carcinoma, resistance to Temsirolimus was associated with low levels of p-AKT and ... subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis (TS), and progressive neuroendocrine tumors of ... From March 30, 2009 to May 5, 2011 the U.S. FDA approved everolimus for the treatment of advanced renal cell carcinoma after ... A G0-G1 cell-cycle blockage can be the consequence of inactivation of mTOR in hypoxia-activated pericytes and endothelial cells ...
... goitre Paget's disease Polymyalgia rheumatica Giant cell arteritis Fibromuscular dysplasia IgG4-related disease Carotid bruit ... which may be caused by a cranial artery bruit Arteriovenous malformation Coarctation of the aorta Hepatocellular carcinoma ...
... it has been found that C1orf142 has larger expression rates in cell line of giant cell lung carcinoma they have high metastatic ... PVR binds to CD96 and CD226 - Natural killer cell receptors. This can cause PVR to possibly be transferred to NK cells and ... The poliovirus receptor plays a role in cell motility during tumor cell invasion and migration. ... and COTL1 in Non-Small Cell Lung Cancer Cell Lines With Different Tumor Metastatic Potential". Journal of Investigative ...
Pleomorphic carcinoma M8030/3 Giant cell and spindle cell carcinoma M8031/3 Giant cell carcinoma M8032/3 Spindle cell carcinoma ... NOS Reserve cell carcinoma Round cell carcinoma Small cell neuroendocrine carcinoma M8042/3 Oat cell carcinoma (C34._) M8043/3 ... fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma ... cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell ...
neoplasm benign neoplasms, such as fibromas, papillomas and giant cell granulomas malignant neoplasms, such as a carcinoma or ... Hyperplasia refers to an increased number of cells, and hypertrophy refers to an increase in the size of individual cells. As ... Subramani, T; Rathnavelu, V; Yeap, SK; Alitheen, NB (Feb 2013). "Influence of mast cells in drug-induced gingival overgrowth". ...
March 2006). "Decreased expression of the human stem cell marker, Rex-1 (zfp-42), in renal cell carcinoma". Carcinogenesis. 27 ... "Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells". Biology of Reproduction. 74 (6): 1041-50 ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... Przyborski SA (2001). "Isolation of human embryonal carcinoma stem cells by immunomagnetic sorting". Stem Cells. 19 (6): 500-4 ...
... hyalinizing spindle cell fused with giant rosette, endometrial stromal sarcoma with hyalinizing giant rosettes, embryonal tumor ... Merkel cell carcinoma, neuroendocrine tumor of skin, seborrheic keratosis, dendritic cell neurofibroma, astroblastoma, large ... Kadono T, Okada H, Okuno T, Ohara K (June 1998). "Basal cell carcinoma with neuroid type nuclear palisading: a report of three ... It can also be seen in nodular basal-cell carcinomas. Pseudopalisading, a visually similar finding, is the formation of ...
Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... "giant-cell carcinoma" should be limited strictly to neoplasms containing only malignant giant cells (i.e. "pure" giant-cell ... Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated ... The cells from giant-cell carcinomas are anaplastic, and show no evidence of cell maturation or differentiation, lacking the ...
These conditions include squamous-cell carcinoma, basal-cell carcinoma, and melanoma. Histopathological examination shows ... Instead, the three are associated with each other because they appear frequently on gingiva-peripheral giant cell granuloma and ... peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases". Minerva Stomatologica. ... Simulating Recurrent Squamous Cell Carcinoma". Archives of Ophthalmology. 74 (2): 229-230. doi:10.1001/archopht. ...
These classifications are spindle cell, squamous cells, matrix-producing, carcinosarcoma, and MCB with osteoclastic giant cell ... The epithelial-type is further classified as squamous cell carcinoma, adenocarcinoma with spindle cell differentiation, and ... proposed a classification system consisting of spindle cell carcinoma, invasive ductal carcinoma with extensive squamous ... Metaplastic carcinoma, otherwise known as metaplastic carcinoma of the breast (MCB), is a heterogeneous group of cancers that ...
... of hepatocellular carcinoma are: fibrolamellar, pseudoglandular (adenoid), pleomorphic (giant cell), and clear cell. In well- ... In poorly differentiated forms, malignant epithelial cells are discohesive, pleomorphic, anaplastic, and giant. The tumor has a ... "Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells". Biochemical ... apoptosis and cell cycle arrest in human HCC cell lines without accompanying cytotoxicity. Thus, IGF-1R-TK inhibition may be a ...
Histological variants of lung cancer classified as sarcomatoid carcinoma include giant cell carcinoma, spindle cell carcinoma, ... Sarcomatoid carcinoma, sometimes referred to as pleomorphic carcinoma, is a relatively uncommon form of cancer whose malignant ... "carcinoma") and mesenchymal tumors ("sarcoma"). It is believed that sarcomatoid carcinomas develop from more common forms of ... Sarcomatoid carcinomas have been identified in the small intestine in rare cases. They may have epithelioid and mesenchymal ...
Characteristic for idiopathic granulomatous mastitis are multinucleated giant cells and epithelioid histiocytes forming non- ... foreign body reaction and granulomatous reaction in a carcinoma must be excluded. The condition is diagnosed very rarely. As ... "A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: Idiopathic granulomatous mastitis". The Breast. ...
However, as HGSC tends to have the same clinical behaviour, regardless of its primary cell origin, determining cell origin is ... Distinguishing between LGSC and HGSC: Necrosis is common in HGSC and absent in LGSC, as are giant (multi- or mononucleated) ... Technically a 'serous carcinoma' can occur anywhere on these membranes, but high-grade serous carcinoma is generally limited to ... tumour cells. Psammoma bodies are more frequent in low-grade serous carcinoma. Tp53 expression is assessed for mutations, ...
Giant-cell carcinoma of the lung Basaloid large cell carcinoma of the lung Clear cell carcinoma of the lung Lymphoepithelioma- ... like carcinoma of the lung Large-cell lung carcinoma with rhabdoid phenotype Large cell neuroendocrine carcinoma of the lung ... LCC is categorized as a type of NSCLC (non-small-cell lung carcinoma) which originates from epithelial cells of the lung. ... "large-cell neuroendocrine carcinoma" (LCNEC), which is believed to derive from neuroendocrine cells. In addition, a "subvariant ...
... pleomorphic carcinoma, (2) spindle cell carcinoma, (3) giant cell carcinoma, (4) carcinosarcoma, or (5) pulmonary blastoma. ... Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Approximately 98% of lung cancers are carcinoma, a term for malignant neoplasms derived from cells of epithelial lineage, and/ ... Carcinoid tumor Salivary gland-like carcinoma Sarcomatoid carcinomas are unique among lung carcinomas in that, although they ...
... spindle cell carcinoma, and giant cell carcinoma. Giant cell carcinoma components are seen much more commonly in patients who ... Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Combined small cell lung carcinoma (or c-SCLC, and rarely rendered as "small-cell lung carcinoma") is a form of multiphasic ... December 1982). "The clinical behavior of "mixed" small cell/large cell bronchogenic carcinoma compared to "pure" small cell ...
In this group are: pleomorphic carcinoma, carcinoma with osteoclast-like stromal giant cells, carcinoma with ... Cells with too much or too little DNA are called aneuploid. Aneuploid cells are more likely to spread than diploid cells. DNA ... Invasive ductal carcinoma, with occasional entrapped normal ducts (arrow) The appearance of cancer cells under a microscope is ... Invasive carcinoma of no special type (NST) also known as invasive ductal carcinoma or ductal NOS and previously known as ...
... it shows presence of epithelioid cell granulomas with Langhans giant cells with or without central caseation necrosis in the ... The condition should be distinguished from: Basal cell carcinoma Sarcoidosis Discoid lupus erythomatosus Leprosy Deep fungal ... squamous cell carcinoma can develop. In the 19th century, the chronic and progressive nature of this disease was particularly ...
Giant cells - considerably larger than their neighbors - may form and possess either one enormous nucleus or several nuclei ( ... Anaplastic astrocytoma, Astrocytoma, Central neurocytoma, Choroid plexus carcinoma, Choroid plexus papilloma, Choroid plexus ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... Necrotic cells send the wrong chemical signals which prevent phagocytes from disposing of the dead cells, leading to a buildup ...
giant cells *Langhans giant cells, Foreign-body giant cell. *Touton giant cells ... carcinoma ... T cells: *CD4+ helper T cells: T cells displaying co-receptor ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
... cells and embryonal carcinoma (EC) cells: opposite sides of the same coin". 》Biochemical Society Transactions》 33 (Pt 6): 1526- ... "Giant leap against diabetes". 2014년 11월 24일.. *↑ Dr. Yury Verlinsky (2009년 7월 20일). "Expert in reproductive technology". 2009년 ... "NIH Stem Cell Basics. What are embryonic stem cells?". 2016년 8월 31일에 원본 문서에서 보존된 문서. 2016년 8월 19일에 확인함.. ... "DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells". 》Cell Cycle (Georgetown
Giant cell carcinoma of the lung. *Nuclear atypia. This article related to pathology is a stub. You can help Wikipedia by ... Certain benign cell types may have pleomorphism, e.g. neuroendocrine cells, Arias-Stella reaction. ... Pleomorphism is a term used in histology and cytopathology to describe variability in the size, shape and staining of cells and ... A micrograph showing cells with marked nuclear shape and size variation, a component of nuclear pleomorphism. ...
Cell Tropism[edit]. Hepadnaviruses, as their "hepa" name implies, infect liver cells and cause hepatitis. This is true not only ... Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ... The virus binds to specific receptors on cells and the core particle enters the cell cytoplasm. This is then translocated to ... "Cell Host & Microbe. 22 (3): 387-399.e6. doi:10.1016/j.chom.2017.07.019. PMC 5604429 . PMID 28867387.. ...
Adenosquamous carcinoma. *Papillary adenocarcinoma. *Giant-cell carcinoma. Small-cell carcinoma. *Combined small-cell carcinoma ... Histologically, it forms clusters of goblet cells containing mucin with a minor admixture of Paneth cells and endocrine cells. ... Goblet cell carcinoid[edit]. Main article: Goblet cell carcinoid. This is considered to be a hybrid between an exocrine and ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ...
子宮頸鉅細胞星形細胞瘤(英语:Subependymal giant cell astrocytoma) ... 鱗狀細胞癌(英语:Squamous-cell thyroid carcinoma). *良性 *甲狀腺腺瘤(英语:Thyroid adenoma) ... 甲狀腺癌(惡性):上皮細胞(英语:Thyroid epithelial cell)癌 *乳突性(英语:Papillary thyroid cancer) ...
... and consist of abnormal hypertrophic ganglion cells that are somewhat similar to Purkinje cells. The amount of white matter in ... which plays a role in cell growth. Mutation in PTEN gene on chromosome no. 10q leads to increased activity of AKT and mTOR ... internal granular layer is focally indistinct and is occupied by large ganglion cells 3,myelinated tracks in outer molecular ...
Adenosquamous carcinoma. *Papillary adenocarcinoma. *Giant-cell carcinoma. Small-cell carcinoma. *Combined small-cell carcinoma ... Large-cell lung carcinoma[edit]. Main article: Large-cell lung carcinoma. Large cell lung carcinoma (LCLC) is a heterogeneous ... Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC ... Squamous cell lung carcinoma[edit]. Main article: Squamous cell carcinoma of the lung ...
... the virus seemed to move from cell to cell, but by around the 12th day, lysis of many infected cells occurred and the virus was ... ACAM2000s virus is cultured in kidney epithelial cells (Vero cells) from an African green monkey. Efficacy and adverse reaction ... Poxviruses are unique among DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus. In ... The life cycle of poxviruses is complicated by having multiple infectious forms, with differing mechanisms of cell entry. ...
Metastatic carcinoma. *Giant-cell tumor of the tendon sheath. *Glomus tumor. *Granular cell tumor ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Follicular dendritic cell sarcoma. Extranodal NK/T-cell lymphoma, nasal type. MCPyV ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... Brain magnetic resonance imaging showing primary central nervous system B-cell non-Hodgkin lymphoma of the sella turcica and ...
Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Li TJ, Cui J (August 2013). "COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma". Asian Pacific ... It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[12][33] ... It is found that patients with erythematous or erosive oral Lichen planus have a higher risk of oral squamous cell carcinoma ...
... mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus ... spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Micrograph of a lung primary small cell carcinoma, a type of carcinoma. The clustered cancerous cells consist primarily of ...
Basal-cell carcinoma. *Wart (caused by the Human papillomavirus; also similar in appearance to molluscum) ... Potential systemic absorption of imiquimod, with negative effects on white blood cell counts overall, and specifically ... which consist of large cells with abundant granular eosinophilic cytoplasm (accumulated virions) and a small peripheral nucleus ...
... such as giant cell carcinoma, spindle cell carcinoma and small-cell carcinoma. ... In order for a normal cell to transform into a cancer cell, the genes that regulate cell growth and differentiation must be ... hepatocellular carcinoma) and human T-cell leukemia virus-1 (T-cell leukemias). Bacterial infection may also increase the risk ... Carcinoma: Cancers derived from epithelial cells. This group includes many of the most common cancers and include nearly all ...
Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ... The relative increase in percentage of CD8+ T cells, caused by a reduction in numbers of CD4+ T cells may be implicated in RAS- ... Mast cells and macrophages are also involved, secreting TNF-α along with the T cells. When early aphthous ulcers are biopsied, ... and the ratio of CD4+ T cells to CD8+ T cells in the peripheral blood of individuals with aphthous stomatitis is decreased.[5] ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Cell-mediated immune responses are also important in limiting the scope and the duration of primary varicella infection. After ... VZV then remains latent in the dorsal ganglion cells of the sensory nerves. Reactivation of VZV results in the clinically ...
Small Cell Lung Carcinoma (SCLC) is the most closely associated with almost 100% of cases occurring in smokers.[56] This form ... "Waking a sleeping giant: the tobacco industry's response to the polonium-210 issue". American Journal of Public Health. 98 (9 ... If the mutation inhibits programmed cell death, the cell can survive to become a cancer, a cell that does not function like a ... If the mutation inhibits programmed cell death, the cell can survive to become a cancer cell. Similarly, acrolein, which is ...
Workers exposed to glyphosate were about twice as likely to get B cell lymphoma.[7] A 2016 systematic review and meta-analysis ... These include the induction of positive trends in the incidence of renal tubule carcinoma and haemangiosarcoma in male mice, ... giant ragweed, and at that time 15 weed species had been confirmed as resistant to glyphosate.[167][174] As of 2010, in the ... and increased pancreatic islet-cell adenoma in male rats.[8] In reproductive toxicity studies performed in rats and rabbits, no ...
Basal and squamous cell carcinomas[edit]. The most common forms of skin cancer in humans, basal and squamous cell carcinomas, ... while the giant Bosch in Brazil began a year later.[95][96] By 2013 it was being used by some 700 million refrigerators, making ... These cancers are relatively mild and rarely fatal, although the treatment of squamous cell carcinoma sometimes requires ... having cells that form when the DNA is damaged by UV radiation. The findings suggest "rising UV levels as a result of ozone ...
Adenosquamous carcinoma. *Papillary adenocarcinoma. *Giant-cell carcinoma. Small-cell carcinoma. *Combined small-cell carcinoma ... Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ... Small-cell lung carcinoma may be derived from these cell lines[60] or neuroendocrine cells,[1] and may express CD44.[60] ...
巨细胞癌(英语:Giant-cell carcinoma of the lung) ... Large-cell lung carcinoma). *Rhabdoid carcinoma(英语:Large-cell ... 非小細胞癌(NSCLC)可粗分為三大類:肺腺癌、鱗狀上皮癌(英语:squamous-cell lung carcinoma),和大細胞癌(英语:large-cell lung carcinoma)[1]。 ... 非小细胞肺癌(英语:Non-small-cell lung carcinoma). *肺鳞癌(英语:Squamous cell lung carcinoma) ... 其细胞株系起源機制尚不完全
... renal cell carcinoma), and certain types of thyroid cancer.[66]. *Trasylol (Aprotinin) Trasylol is a trypsin inhibitor used to ... "Stock of former Nazi chemicals giant to be delisted". Deutsche Welle ... Nexavar (sorafenib) is a kinase inhibitor used in the treatment of liver cancer (hepatocellular carcinoma), kidney cancer ( ... Cell Proliferation. 39 (2): 147-155. doi:10.1111/j.1365-2184.2006.00377.x. PMID 16542349.. ...
Adenosquamous carcinoma. *Papillary adenocarcinoma. *Giant-cell carcinoma. Small-cell carcinoma. *Combined small-cell carcinoma ... See also: Combined small-cell lung carcinoma. The term "combined small-cell lung carcinoma" (c-SCLC) refers to a multiphasic ... About 2% of all lung cancers are non-carcinoma (mainly sarcoma, tumors of hematopoietic origin, or germ cell tumors.[5] These ... While there have been no randomized clinical trials of targeted agents in combined small-cell lung carcinoma (c-SCLC),[citation ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ... An odontoblast cell showing odontoblast process (not in proportion - in reality this process is far longer than the body of the ... Giant-cell. *Focal epithelial hyperplasia. *Fordyce spots. *Hairy leukoplakia. *Hand, foot and mouth disease ...
squamous-cell carcinoma. *basal-cell carcinoma. *Merkel-cell carcinoma. *nevus sebaceous. *trichoepithelioma ... Cell death signaling. *Apoptosis is increased in monocytes and keratinocytes. *Expression of Fas by B cells and T cells is ... This material may present a threat to the tolerization of B cells and T cells. Dendritic cells in the germinal center may ... Early apoptotic cells express "eat-me" signals, of cell-surface proteins such as phosphatidylserine, that prompt immune cells ...
"KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics". Viruses. 8 (11): ... Once the virus newly infects a cell, the lipid membrane is shed and the virion travels to the nucleus. The viral genome is ... KSHV is a rhadinovirus, and is remarkable since it has stolen numerous genes from host cells including genes that encode for ... The viral episome is chromatinized upon entry into the host cell nucleus.[15] LANA tethers the viral DNA to cellular ...
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma PMID 24532092 https ... Interventions for prevention of giant retinal tear in the fellow eye PMID 22336825 ... Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer ... Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small-volume primary oropharyngeal carcinoma PMID 27943254 ...
... with squamous cell carcinoma being the most common type. The incidence of squamous cell carcinoma increases to 37% when the ... "Giant cutaneous horn in an African woman: a case report". Journal of Medical Case Reports. 1: 170. doi:10.1186/1752-1947-1-170 ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... Tenderness at the base of the lesion is often a clue to the presence of a possible underlying squamous cell carcinoma.[citation ...
Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... "giant-cell carcinoma" should be limited strictly to neoplasms containing only malignant giant cells (i.e. "pure" giant-cell ... Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated ... The cells from giant-cell carcinomas are anaplastic, and show no evidence of cell maturation or differentiation, lacking the ...
Definition of giant cell carcinoma of thyroid gland. Provided by Stedmans medical dictionary and Includes medical ... giant cell carcinoma of thyroid gland. Definition: a rapidly progressive undifferentiated carcinoma observed in the thyroid ... gland, characterized by numerous, unusually large, anaplastic cells derived from glandular epithelium of the thyroid gland. ...
Less than 1% of basal cell carcinomas are giant basal cell carcinomas. Giant basal cell carcinomas are rare. They ... Giant basal cell carcinomas of 10 cm or greater are associated with a high rate of metastasis. We report a case of giant basal ... A giant polypoid basal cell carcinoma of the lower extremity.. Handjani F1, Shahbaz S, Sari-Aslani F, Aghaei S, Ali-Zadeh AA. ... cell carcinoma of the leg which is not associated with neglect and no signs of metastasis, despite being more than 10 cm in ...
... Pauline Joy F. Santos, Christina ... Pauline Joy F. Santos, Christina Prendergast, and Amber Leis, "Giant Anterior Chest Wall Basal Cell Carcinoma: An Approach to ...
... Lucía ... "Osteoclastic Giant Cell Rich Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature," Case ...
Basal cell carcinoma: Electrodessication and curettage. Take Quiz. Does indoor tanning affect an individuals sun protection ... Basal cell carcinoma accounts for approximately 80% of all skin cancers in the United States. ... Recognizing giant basal cell carcinomas. Take Quiz. ... Managing giant basal cell carcinomas Take Quiz. ... Recognizing & treating cutaneous myoepithelial carcinoma, Pt 1. Take Quiz. Recognizing rare forms of protoporphyria. Take Quiz ...
Giant Cell" by people in this website by year, and whether "Carcinoma, Giant Cell" was a major or minor topic of these ... "Carcinoma, Giant Cell" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Carcinoma, Giant Cell*Carcinoma, Giant Cell. *Carcinomas, Giant Cell. *Cell Carcinoma, Giant ... Below are the most recent publications written about "Carcinoma, Giant Cell" by people in Profiles. ...
Normal tissue is growth-limited, i.e., cell reproduction is equal to... Explanation of giant cell carcinoma ... Find out information about giant cell carcinoma. see neoplasm neoplasm or tumor, tissue composed of cells that grow in an ... Giant cell carcinoma is a non-small cell carcinoma solely comprising anaplastic, giant tumor cells (Figure 2, D).. Sarcomatoid ... Histologic features that allow for separation of pleomorphic carcinoma from spindle cell carcinoma, giant cell carcinoma, ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
UCOCGC; poorly differentiated carcinoma with osteoclastic giant cells Images Poorly differentiated carcinoma with osteoclast- ... undifferentiated carcinoma with osteoclastic giant cells. undifferentiated carcinoma with osteoclastic giant cells. Thursday 29 ... Undifferentiated carcinoma with osteoclastic giant cells (UCOCGC) of the pancreas associated with the familial atypical ... Poorly differentiated carcinoma with osteoclast-like giant cells of pan.tail. * ...
What is lung giant cell carcinoma-derived chemotactic protein? Meaning of lung giant cell carcinoma-derived chemotactic protein ... What does lung giant cell carcinoma-derived chemotactic protein mean? ... lung giant cell carcinoma-derived chemotactic protein explanation free. ... Looking for online definition of lung giant cell carcinoma-derived chemotactic protein in the Medical Dictionary? ...
... giant cell carcinoma of thyroid gland explanation free. What is giant cell carcinoma of thyroid gland? Meaning of giant cell ... What does giant cell carcinoma of thyroid gland mean? ... Looking for online definition of giant cell carcinoma of ... giant cell carcinoma of thyroid gland. gi·ant cell car·ci·no·ma of thy·roid gland. a rapidly progressive undifferentiated ... Giant cell carcinoma of thyroid gland , definition of giant cell carcinoma of thyroid gland by Medical dictionary https:// ...
... for this lesion was found to be giant cell carcinoma - a diagnosis contrary to the original diagnosis of clear cell ... for this lesion was found to be giant cell carcinoma - a diagnosis contrary to the original diagnosis of clear cell ... for this lesion was found to be giant cell carcinoma - a diagnosis contrary to the original diagnosis of clear cell ... for this lesion was found to be giant cell carcinoma - a diagnosis contrary to the original diagnosis of clear cell ...
Cutaneous squamous cell carcinoma & perineural invasion. Take Quiz. Incidence and trends of cutaneous squamous cell carcinoma. ... Basal cell carcinoma: Electrodessication and curettage. Take Quiz. Does indoor tanning affect an individuals sun protection ... Basal cell carcinoma accounts for approximately 80% of all skin cancers in the United States. ... Recognizing giant basal cell carcinomas. Take Quiz. ... Cutaneous squamous cell carcinoma and vitamin A. Take Quiz. ...
Build: Sat Nov 17 23:53:08 EST 2018 (commit: a759bb7). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
define Carcinoma, Giant Cell. Explain Carcinoma, Giant Cell. What is Carcinoma, Giant Cell? Carcinoma, Giant Cell FAQ. ... Carcinoma, Giant Cell. Medical Dictionary -> Carcinoma, Giant Cell. Search: Carcinoma, Giant Cell. An epithelial neoplasm ... characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic ...
We still observe on the 21st century cases of giant basal cell carcinoma. In our case multiple factors could explain the size ... Final diagnosis: Giant basal cell carcinoma of the scalp. ... biopsy specimen confirmed the diagnosis of basal cell carcinoma ... Giant basal cell carcinoma of the scalp. Monia Youssef, Hichem Belhadjali The Pan African Medical Journal. 2014;19:142. doi: ... Giant basal cell carcinoma of the scalp Cite this: The Pan African Medical Journal. 2014;19:142. doi:10.11604/pamj.2014.19. ...
A 44-year-old woman (Case 1) had OGCs accompanying invasive ductal carcinoma, and an 83-year-old woman (Case 2) with ... Immunohistochemically, in both cases, tumoural and non-tumoural cells strongly expressed VEGF and MMP12, which promote ... Breast carcinoma with osteoclastic giant cells (OGCs) is characterized by multinucleated OGCs, and usually displays ... Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of ...
... a case report ABSTRACT Multicentric giant cell tumors represent less than 1% of all giant cell tumors of bones.... ... Squamous Cell Carcinoma Case Study. 1334 Words , 6 Pages. Screening method and public awareness are lacking. Due to this, ... Metachronous Multicentric Giant cell tumor: a case report ABSTRACT Multicentric giant cell tumors represent less than 1% of all ... Multicentric giant cell tumor of bone. Acta Orthop Belg 2007; 73: 289-99. 4. Park IH, Jeon IH. Multicentric giant cell tumor of ...
We report giant cell carcinoma of endometrium in an Indian female, which according to our best knowledge, is the first case ... is limited and the prognostic significance of the presence and the extent of a giant cell component in endometrial carcinoma ... is a rare and an aggressive tumor that should be distinguished from other endometrial tumors with a prominent giant cell ... Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells. Am ...
... of basal cell carcinomas (BCC), and studies regarding it are scarce. Our objective was to investigate the clinical- ... AbstractIntroductionGiant basal cell carcinoma (GBCC) is a tumor ≥5 cm in size, with aggressive biological behavior, that ... IntroductionGiant basal cell carcinoma (GBCC) is a tumor ≥5 cm in size, with aggressive biological behavior, that represents 1 ... of basal cell carcinomas (BCC), and studies regarding it are scarce. Our objective was to investigate the clinical- ...
These images are intended for educational purposes and may be freely used for such as long as the Papanicolaou Society and the Bethesda System for Reporting Thyroid Cytopathology is credited.. ...
Giant Adenoid Basal Cell Carcinoma. Herring, Stephen M. Herring, Stephen M. Less ...
MalaCards based summary : Lung Giant Cell Carcinoma, also known as carcinoma, giant cell, is related to spindle cell carcinoma ... MalaCards integrated aliases for Lung Giant Cell Carcinoma:. Name: Lung Giant Cell Carcinoma 12 15 17 ... Large Undifferentiated Cells MalaCards organs/tissues related to Lung Giant Cell Carcinoma:. 40 Lung, Pancreas, Thyroid, ... Selective effect of O-alkyl lysophospholipids on the growth of a human lung giant cell carcinoma cell line. 61 ...
Giant Basal Cell Carcinoma can be destructive and more aggressive and Giant Basal Cell Carcinoma can cause mortality and ... A Delayed Diagnosis On Scalp: The Case Of Giant Basal Cell Carcinoma. Saçlı Deride Gecikmiş Tanı: Dev Bazal Hücreli Karsinom ... She had Giant Basal Cell Carcinoma for many years on scalp and its diameters was 16x12 cm. She had dura mater metastasis but ... According to description of American Joint Comittee on Cancer describes Giant Basal Cell Carcinoma as the diameter of tumor is ...
Context Acinar cell carcinoma is rare disease of exocrine pancreas with an indolent course and favorable tumor biology. It ... Giant Acinar Cell Carcinoma of Pancreas Presenting In a Young Patient Context Acinar cell carcinoma is rare disease of exocrine ... Conclusion Differential diagnosis of acinar cell carcinoma of pancreas should be considered in young patient with large tumor ... Histopathological examination with immunohistochemistry revealed acinar cell carcinoma of pancreas. ...
Approach to management of giant basal cell carcinomas. Together they form a unique fingerprint. * Giant Cell Carcinoma ... title = "Approach to management of giant basal cell carcinomas",. abstract = "Basal cell carcinoma (BCC) is a common ... Mott, S. E., Hunter, W. J., Silva, E., & Huerter, C. (2017). Approach to management of giant basal cell carcinomas. Cutis, 99(5 ... Mott, SE, Hunter, WJ, Silva, E & Huerter, C 2017, Approach to management of giant basal cell carcinomas, Cutis, vol. 99, no. ...
Like benign tumors, malignant tumors do not respond to body mechanisms... Explanation of Rare Giant cell carcinoma ... Find out information about Rare Giant cell carcinoma. cancer cancer, in medicine, common term for neoplasms, or tumors, that ... Related to Rare Giant cell carcinoma: giant cell tumor, giant cell sarcoma ... Rare Giant cell carcinoma , Article about Rare Giant cell carcinoma by The Free Dictionary https://encyclopedia2. ...
Carcinoma, Giant Cell / mortality. Carcinoma, Giant Cell / pathology. Carcinoma, Giant Cell / surgery. Cell Differentiation. ... MeSH-major] Carcinoma / diagnosis. Carcinoma / therapy. Carcinoma, Giant Cell / diagnosis. Carcinoma, Giant Cell / therapy. ... Title] Ovarian undifferentiated carcinoma resembling giant cell carcinoma of the lung.. *Giant cell carcinoma (GCC) is a highly ... cell carcinomas (n=59), adenocarcinomas (n=130), large-cell carcinomas (n=15) and giant-cell carcinomas (n=5)]. ...
  • Although it is common in the lung cancer literature to refer to histologically mixed tumors containing significant numbers of malignant giant cells as "giant-cell carcinomas", technically a diagnosis of "giant-cell carcinoma" should be limited strictly to neoplasms containing only malignant giant cells (i.e. "pure" giant-cell carcinoma). (
  • About 1% of lung cancers are sarcomas, germ cell tumors, and hematopoietic tumors, while 99% of lung cancers are carcinoma. (
  • Carcinomas are tumors composed of transformed, abnormal cells with epithelial tissue architecture and/or molecular characteristics, and which derive from embryonic endoderm. (
  • Metachronous Multicentric Giant cell tumor: a case report ABSTRACT Multicentric giant cell tumors represent less than 1% of all giant cell tumors of bones. (
  • We report a case of young girl with metachronous multicentric giant cell tumors with 5 documented lesions in a monomelic lower limb. (
  • These tumors had typical radiological appearance and the diagnosis of giant cell tumor was confirmed on histopathology. (
  • Giant cell carcinoma of the endometrium is a rare and an aggressive tumor that should be distinguished from other endometrial tumors with a prominent giant cell component, including trophoblastic tumors, certain primary sarcomas, and malignant mixed müllerian tumors. (
  • Like benign tumors, malignant tumors do not respond to body mechanisms that limit cell growth. (
  • Extra osseous manifestations of osteoclast-like giant cell tumors (OGCTs) in soft tissue are very unusual, especially in the urinary bladder. (
  • Malignant liver tumors with osteoclast-like giant cells are rare. (
  • A literature search showed 17 previously reported cases that included the following: (1) 8 undifferentiated hepatocellular carcinomas, (2) 5 sarcomatous tumors with osteoclast-like giant cells associated with intrahepatic cholangiocarcinoma or liver cystadenocarcinoma, and (3) 4 sarcomatoid tumors with osteoclast-like giant cells associated with areas of a conventional hepatocellular carcinoma. (
  • The clinical appearance of these tumors might be consistent with an unusual variant of hepatocellular carcinoma. (
  • Only 4 of the 17 tumors that have been reported could be classified as sarcomatoid hepatocellular carcinomas with osteoclast-like giant cells, according to the World Health Organization classification, because they comprised sarcomatoid tumors with osteoclast-like giant cells and areas of classic hepatocellular carcinoma. (
  • The histogenesis of the sarcomatoid portion of these liver tumors is controversial because of the similarity to giant cell tumor of bone or other mesenchymal tumors that have osteoclast-like giant cells. (
  • Nishiyama RH, Dunn EL, Thompson NW (1972) Anaplastic spindle-cell and giant-cell tumors of the thyroid gland. (
  • Tumors that affect the endocrine functions of the pancreas are called neuroendocrine or islet-cell tumors. (
  • Functioning islet cell tumors continue to make hormones. (
  • Most of these tumors are benign, but non-functioning tumors are more likely to be malignant, islet-cell carcinomas. (
  • 5] Manstein CH, Gottlieb N, Manstein ME, Manstein G. Giant basal cell carcinoma: a series of seven T3 tumors without metastasis. (
  • Unusual and giant tumors of head and neck region. (
  • Undifferentiated carcinomas with osteoclastic giant cells of the pancreas (OGC) are rare tumors. (
  • This phenomenon can occur in tumors but also among non-tumor cells. (
  • Spindle cell tumors of the pleura, as well as those tumors primary from the chest wall or mediastinum, may present as either localized or diffuse masses and, depending on the extent of thoracic involvement, may be difficult to distinguish from those of pulmonary origin. (
  • Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx. (
  • Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma 9. (
  • 13. Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma 14. (
  • Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non-seminomatous tumor C) Teratoma with malignant transformation 17. (
  • Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis 18. (
  • Proton beam radiation therapy uses high energy protons to kill tumor cells and shrink tumors. (
  • We additionally find that cholangiocarcinoma also develops in these mice, and some tumors display features of both HCC and cholangiocarcinoma, suggestive of origin from liver progenitor cells. (
  • Significantly, tumor cell lines isolated from tumors lacking both Trp53 and Ink4a/Arf display enhanced invasion activity in vitro relative to those lacking Trp53 alone. (
  • In the United States, approximately 90% of urinary tract tumors are urothelial in origin, with 1-7% of tumors represented by primary squamous cell carcinoma and another 2% being primary bladder adenocarcinomas. (
  • It has been reported that CD109 is expressed in a subset of hematopoietic cells, endothelial cells and several kinds of human tumors. (
  • Zheng G, Ettinger DS, Maleki Z. Utility of the quantitative Ki-67 proliferation index and CD56 together in the cytologic diagnosis of small cell lung carcinoma and other lung neuroendocrine tumors. (
  • Less differentiated carnomas have fucised glands called cribriform glands, as well as solid nests or sheets of tumor cells, and many tumors have two or more of these patterns. (
  • Radiation dermatitis is one of the commonest side effects of ionizing radiation which is applied in radiotherapy of carcinoma of all localizations, most frequently of tumors of breast, head and neck region, lungs and soft tissue sarcomas. (
  • Squamous cell carcinomas have been divided into a superficially invasive type and invasive type. (
  • VIN is found adjacent to 60-80% of superficially invasive squamous cell carcinomas and 25% of deeply invasive carcinomas. (
  • To analyze the impact of HPV profiles of vulvar precancerous lesions for their classification and to assess the presumable efficacy of the prophylactic HPV vaccination, 269 vulvar excisions representing lichen sclerosus, lichen simplex chronicus, condylomata acuminata, d-VIN, all grades of u-VIN and squamous cell carcinomas were subjected to the HPV typing by use of GP5+/6+ polymerase chain reaction and reverse line blot hybridization. (
  • The spectrum of HPV types found in vulvar squamous cell carcinomas indicates that the efficacy of HPV vaccination in preventing vulvar cancer might be diminished in the studied population, because the recently developed prophylactic vaccines are targeted against a limited number of HPV types. (
  • High-level expression of CD109 is frequently detected in lung squamous cell carcinomas. (
  • She is investigating the role of human papilloma virus (HPV) in head and neck squamous cell carcinomas. (
  • Application of the hybrid capture 2 assay to squamous cell carcinomas of the head and neck: a convenient liquid-phase approach for the reliable determination of human papillomavirus status. (
  • Introduction: Basal and squamous cell carcinomas are often grouped together and referred to as non-melanoma skin cancer. (
  • Undifferentiated carcinoma with osteoclastic giant cells (UCOCGC) of the pancreas associated with the familial atypical multiple mole melanoma syndrome (FAMMM). (
  • Context Acinar cell carcinoma is rare disease of exocrine pancreas with an indolent course and favorable tumor biology. (
  • Histopathological examination with immunohistochemistry revealed acinar cell carcinoma of pancreas. (
  • Conclusion Differential diagnosis of acinar cell carcinoma of pancreas should be considered in young patient with large tumor size. (
  • Pancreatic cancer happens when uncontrolled cell growth begins in a part of the pancreas. (
  • Scientists do not know exactly why uncontrolled cell growth happens in the pancreas, but they have identified some possible risk factors. (
  • Undifferentiated (Anaplastic) Carcinoma of the Pancreas with Osteoclast-Like Giant Cells Showing Various Degree of Pancreas Duct Involvement. (
  • Context Undifferentiated (anaplastic) carcinoma of the pancreas with osteoclast-like giant cells is exceedingly rare. (
  • Case report We report the case of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells, showing an intraductal growth pattern with various degree of pancreas duct involvement in the different areas. (
  • Conclusions Our findings support the epithelial origin of undifferentiated carcinoma of the pancreas with osteoclast-like giant cells. (
  • Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) 7. (
  • Endocrine carcinoma of pancreas and digestive tract 23. (
  • Eight major taxa of lung carcinomas are recognized within the WHO-2004 classification: Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland-like carcinoma The subclassification of GCCL among these major taxa has undergone significant changes in recent decades. (
  • Endometrial adenocarcinoma with a component of giant cell carcinoma. (
  • 90% of bladder cancers are transitional cell carcinoma and 8- 9% are squamous cell carcinoma, adenocarcinoma, sarcomas, small cell carcinoma and secondary deposits from cancers elsewhere in the body. (
  • Carbon ion radiotherapy for basal cell adenocarcinoma of the head and neck: preliminary report of six cases and review of the literature. (
  • Clear cell adenocarcinoma. (
  • However, some are not, and prostatic adenocarcinoma is second only to lung carcinoma as a cause for tumor-related deaths among males. (
  • Literature search showed no previous reports of sarcomatoid hepatocellular carcinoma with osteoclast-like giant cells in which the sarcomatous tumor could be described unequivocally as a transformed or metaplastic portion of classic liver cell carcinoma based on morphology or additional immunohistochemical studies including reactivity with heppar-1 antibody. (
  • We evaluated a patient who had sarcomatoid hepatocellular carcinoma that was associated with osteoclast-like giant cells. (
  • Numerous pleomorphic giant cells with an immunohistochemical sarcomatoid profile were present in the undifferentiated carcinoma with osteoclast-like giant cells. (
  • Primary pulmonary sarcomas must be distinguished from the more frequent occurrence of sarcoma metastatic to the lung, primary pulmonary sarcomatoid carcinoma, and diffuse malignant mesothelioma involving the lung. (
  • In practice, a tumor that is initially thought to be a primary sarcoma of the lung can prove, on further inquiry into patient history, to be a late metastasis from a primary soft tissue tumor or, on further sampling, to be a sarcomatoid carcinoma. (
  • The availability of multiple cytokeratin antibody tests has improved the identification of sarcomatoid carcinomas and diffuse malignant mesothelioma. (
  • Sarcomatoid carcinoma of lung 12. (
  • A histological examination of the surgical specimen revealed a well-differentiated infiltrative cutaneous squamous cell carcinoma. (
  • Cutaneous squamous cell carcinoma can reach a huge size if left untreated. (
  • Baum CL, Wright AC, Martinez JC, Arpey CJ, Brewer JD, Roenigk RK , Otley CC. A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management. (
  • Osteoclastic-like giant cells in a cutaneous squamous cell carcinoma. (
  • CD-10 immunostaining differentiates superficial basal cell carcinoma from cutaneous squamous cell carcinoma. (
  • Mutilating, horrifying, aggressive basal cell carcinoma (BCC) is a rare cutaneous neoplasm. (
  • Giant basal cell carcinoma, defined as a tumor that is larger than 5 cm in diameter, is a very rare type of cutaneous malignancy accounting for 0.5-1% of all basal cell carcinomas. (
  • Trans urethral resection was done and the histomorphology and immunoperoxidase profile was compatible with urothelial carcinoma with osteoclast-like giant cells so called Osteoclast-rich undifferentiated urothelial carcinoma .patient developed local recurrence within few weeks of TURBT. (
  • Other areas showed large number of osteoclast-like giant cells and focal areas showing invasion of smooth muscle. (
  • CD 68 outlined the cytoplasm membrane of osteoclast like giant cells. (
  • The histomorphology and immunoperoxidase profile was compatible with urothelial carcinoma with osteoclast-like giant cells so called Osteoclast-rich undifferentiated urothelial carcinoma (Figure1). (
  • Light microscopic findings including osteoclast-like giant cells, and the strong reaction of heppar-1 antibody with cells of the sarcomatous part of the tumor, confirmed that this sarcomatous element was a metaplastic or transformed portion of hepatocellular carcinoma. (
  • however, undifferentiated carcinoma with osteoclast-like giant cells might have a more favorable prognosis. (
  • Only few case reports of mucinous cystic pancreatic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells have been described in the literature. (
  • We present the second case of an indeterminate mucin-producting cystic neoplasm containing an area of carcinoma with osteoclast-like giant cells. (
  • Pathological examination revealed a mucinous cystic neoplasm with a component of an undifferentiated carcinoma with osteoclast-like giant cells. (
  • The lack of ovarian-type stroma in a pancreatic mucinous cystic neoplasm and the presence of pleomorphic giant cells in an undifferentiated carcinoma with osteoclast-like giant cells could be a marker of a poor prognosis. (
  • The adrenal mass was resected and histopathologic examination revealed a highly pleomorphic malignant spindle cell neoplasm diffusely infiltrating the adrenal parenchyma with an immunoprofile consistent with that of a leiomyosarcoma. (
  • Adrenocortical carcinoma is a rare, highly malignant neoplasm that originates in the adrenal cortex and is difficult to differentiate from renal cell carcinoma, especially if it is gigantic and nonfunctional. (
  • As a general rule that is true for all lung lesions, the pathologist should be certain to obtain all clinical history when confronted with a malignant spindle cell lesion in the lung. (
  • Malignant fibrous histiocytoma, giant cell type, of the breast mimicking metaplastic carcinoma. (
  • Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type , is related to malignant giant cell tumor of soft parts and bone giant cell sarcoma . (
  • An important gene associated with Malignant Giant Cell Tumor is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Transcriptional misregulation in cancer . (
  • Giant basal cell carcinomas of 10 cm or greater are associated with a high rate of metastasis. (
  • We report a case of giant basal cell carcinoma of the leg which is not associated with neglect and no signs of metastasis, despite being more than 10 cm in diameter. (
  • Basal cell carcinoma is a slowly growing tumor and it usually shows local invasion and rarely metastasis. (
  • Notably, in pancreatic cancer, the cell-in-cell phenomenon is associated with reduced metastasis, which is the opposite of what happens in other tumor types. (
  • We describe here a metastatic HCC model generated after the somatic introduction of the mouse polyoma virus middle T antigen to mice with liver-specific deletion of the Trp53 tumor suppressor locus and show the cell autonomous effect of p53 loss of function on HCC metastasis. (
  • Furthermore, because all cells within the mouse lack the p53 tumor suppressor, it is not possible to identify cell autonomous requirements for tumor metastasis using these mice. (
  • Orbital metastasis of keratinizing squamous cell cervical carcinoma with giant cells. (
  • A case of orbital metastasis of cervical keratinizing squamous cell carcinoma is presented. (
  • Therefore, the researchers explored the link between metabolic reprogramming - where cancer cells evolve to rely on two key metabolic processes to support their growth and survival - and cancer cell growth, metastasis and therapeutic resistance to Imbruvica in MCL. (
  • We report a rare case with osteoclast like giant cell urothelial carcinoma of the urinary bladder. (
  • Some areas showed low grade urothelial carcinoma. (
  • Bladder cancer is a heterogeneous disease including conventional urothelial carcinoma (UC) and its histologic variants, and non-urothelial carcinoma, including squamous and glandular neoplasms. (
  • Pleomorphic giant-cell urothelial carcinoma syncytiotrophoblastic giant cells. (
  • Ubiquilin2 as a novel marker for detection of urothelial carcinoma cells in urine. (
  • Light microscopy showed that part of the tumor had features of classic hepatocellular carcinoma. (
  • Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. (
  • Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults and is currently the most common cause of death in people with cirrhosis. (
  • Young adults afflicted by the rare fibrolamellar variant of hepatocellular carcinoma may have none of the typical risk factors, i.e. cirrhosis and hepatitis. (
  • The risk of hepatocellular carcinoma in type 2 diabetics is greater (from 2.5 to 7.1 times the nondiabetic risk) depending on the duration of diabetes and treatment protocol. (
  • A suspected contributor to this increased risk is circulating insulin concentration such that diabetics with poor insulin control or on treatments that elevate their insulin output (both states that contribute to a higher circulating insulin concentration) show far greater risk of hepatocellular carcinoma than diabetics on treatments that reduce circulating insulin concentration. (
  • Giant nonfunctioning carcinoma of the adrenal cortex mimicking renal cell carcinoma: a diagnostic dilemma. (
  • and was highly suggestive of renal cell carcinoma. (
  • Adults with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. (
  • Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder 16. (
  • Renal cell carcinoma and hepatitis C virus infection: Is there any cause-outcome relationship? (
  • requires PA Rationale Axitinib is a kinase inhibitor FDA approved for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy. (
  • Clear cell papillary renal cell carcinoma (CCPRCC) is a novel tumor entity that was recently recognized as a new distinct epithelial tumor within the current classification system. (
  • Renal cell carcinoma (RCC), P504s/AMACR, Melan A, and HMB45 were negative in tumor cells in all cases examined. (
  • Zurück zum Zitat Adam J, Couturier J, Molinie V, Vieillefond A, Sibony M (2011) Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases. (
  • Excludes basal and squamous cell skin cancers and in situ carcinomas except urinary bladder. (
  • Histologic features that allow for separation of pleomorphic carcinoma from spindle cell carcinoma, giant cell carcinoma , carcinosarcoma, and blastoma are summarized in Table 1. (
  • A 44-year-old woman (Case 1) had OGCs accompanying invasive ductal carcinoma, and an 83-year-old woman (Case 2) with carcinosarcoma. (
  • Here, we report two cases of breast carcinoma with OGCs associated with invasive ductal carcinoma (Case 1) or carcinosarcoma (Case 2). (
  • Lung Giant Cell Carcinoma, also known as carcinoma, giant cell , is related to spindle cell carcinoma and carcinosarcoma , and has symptoms including fever , dyspnea and hemoptysis . (
  • 1-3) Other much less common types of PPC include clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma, and carcinosarcoma. (
  • Two cases of breast carcinoma with osteoclastic giant cells: Are the osteoclastic giant cells pro-tumoural differentiation of macrophages? (
  • Breast carcinoma with osteoclastic giant cells (OGCs) is characterized by multinucleated OGCs, and usually displays inflammatory hypervascular stroma. (
  • Breast carcinoma with osteoclastic giant cells is a rare entity that falls under the WHO classification of invasive ductal carcinoma, not otherwise specified [ 1 ]. (
  • This tumor is characterized by the presence of osteoclastic giant cells (OGCs), the nature of which remains controversial. (
  • The characteristic feature of this highly lethal malignancy is the distinctive light microscopic appearance of its extremely large cells, which are bizarre and highly pleomorphic, and which often contain more than one huge, misshapen, pleomorphic nucleus ("syncytia"), which result from cell fusion. (
  • The tumor had sheets of large pleomorphic cells with high mitotic rate, pathologic mitosis and large areas of necrosis. (
  • Immunohistochemistry performed on 24 cases revealed that osteoclastic cells expressed the histiocytic marker CD68, and background spindle cells and pleomorphic/giant carcinoma cells often showed p53 and often lacked cytokeratin. (
  • Asparagine limitation in melanoma and pancreatic cancer cells activates receptor tyrosine kinase-MAPK signalling as part of a feedforward mechanism involving mammalian target of rapamycin complex 1 (mTORC1)-dependent increase in MAPK-interacting kinase 1 (MNK1) and eukaryotic translation initiation factor 4E (eIF4E), resulting in enhanced translation of activating transcription factor 4 ( ATF4 ) mRNA. (
  • RATIONALE: Vaccines made from gene-modified pancreatic cancer cells may make the body build an immune response to kill tumor cells. (
  • Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine. (
  • The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem-cell signaling in pancreatic cancer. (
  • However, follow-up radiographs performed 9 months later showed a radiolucent mass that eventually, after open biopsy and histologic evaluation, was determined to be giant cell tumor. (
  • Clinicopathologic analysis of 187 high-grade endometrial carcinomas of different histologic subtypes: similar outcomes belie distinctive biologic differences. (
  • However, histologic examination after radical nephrectomy confirmed the mass to be an adrenocortical carcinoma compressing the kidney. (
  • 8] Naumann IC, Cordes SR. Giant basal cell carcinoma of the forehead with extensive intracranial involvement. (
  • Neuroendocrine Carcinoma of the Nasal. (
  • Neuroendocrine carcinoma including carcinoid of the lung 24. (
  • Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells. (
  • 4] Vico P, Fourez T, Nemec E, Andry G, Deraemaecker R. Aggressive basal cell carcinoma of head and neck areas. (
  • Basaloid squamous carcinoma (BSC), a distinct aggressive variant of squamous cell carcinoma (SCC), presents preference for head and neck region, specially base of tongue. (
  • Mendelsohn G, Baylin SB, Bigner SH, Wells SA Jr, Eggleston JC (1980) Anaplastic variants of medullary thyroid carcinoma. (
  • Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated lung cancer, traditionally classified within the non-small-cell lung carcinomas (NSCLC). (
  • However, in a more recent series of 4,212 consecutive lung cancer cases, only one (0.024%) lesion was determined to be a "pure" giant-cell carcinoma after complete sectioning of all available tumor tissue. (
  • Recent studies have also focused on their direct or indirect pro-tumoural functions: enhancement of angiogenesis and cancer cell growth and spread [ 4 , 6 ]. (
  • According to description of American Joint Comittee on Cancer describes Giant Basal Cell Carcinoma as the diameter of tumor is 5 cm or above. (
  • Basal cell carcinoma (BCC) is a common nonmelanoma skin cancer with increasing incidence in the United States and worldwide. (
  • Like other cancers, lung cancer occurs after repeated insults to the genetic material of the cell. (
  • In some types, the cancer cells themselves produce hormones or other substances that can create an imbalance and result in various symptoms. (
  • Urine cytology was negative for cancer cells. (
  • The name comes from the type of hormone-producing cell where the cancer starts. (
  • Overexpression of this protein leads to increased growth of cancer cells. (
  • Here we demonstrate a role of translational reprogramming in the survival of asparagine-restricted cancer cells. (
  • Trastuzumab (Herceptin) was shown to slow progression of HER2-positive uterine serous carcinoma, one of the most aggressive forms of endometrial cancer. (
  • Consensus for nonmelanoma skin cancer treatment: basal cell carcinoma, including a cost analysis of treatment methods. (
  • As the thyroid cancer can uptake iodine , radioactive iodine is commonly used for the treatment of thyroid carcinomas. (
  • Anaplastic carcinoma (also called giant and spindle cell cancer) is the most dangerous form of thyroid cancer. (
  • Medullary carcinoma is a cancer of non-thyroid hormone-producing cells that are normally present in the thyroid gland. (
  • This phase III ALCHEMIST trial studies how well crizotinib works in treating patients with stage IB-IIIA non-small cell lung cancer that has been removed by surgery and has a mutation in a protein called anaplastic lymphoma kinase (ALK). (
  • Crizotinib may be an effective treatment for patients with non-small cell lung cancer and an ALK fusion mutation. (
  • This phase III ALCHEMIST trial studies how well erlotinib hydrochloride compared to observation works in treating patients with stage IB-IIIA non-small cell lung cancer that has been completely removed by surgery. (
  • OBJECTIVE: In this study, we used an adenoviral vector -melanoma differentiation-associated gene-7 (Ad-mda7) to examine the effect of the ectopic production of MDA-7/IL-24 on cell migration and invasion by human cervical cancer cells. (
  • A small molecule drug may help to overcome resistance to Imbruvica (ibrutinib) in patients with mantle cell lymphoma (MCL), according to preclinical study findings from The University of Texas MD Anderson Cancer Center. (
  • Basal cell carcinoma is the most common form of skin cancer. (
  • Radiation-Related Risk of Basal Cell Carcinoma: A Report From the Childhood Cancer Survivor Study. (
  • This type of treatment blocks the growth and spread of cancer cells while limiting damage to healthy cells. (
  • Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells. (
  • Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cancer stem-like cells acquire pronounced migratory potential. (
  • LINC00312 inhibits the migration and invasion of bladder cancer cells by targeting miR-197-3p. (
  • Detection of multiple mutations in urinary exfoliated cells from male bladder cancer patients at diagnosis and during follow-up. (
  • Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway. (
  • It also establishes that radiographic findings do not always correlate with actual disease process, for this lesion was found to be giant cell carcinoma - a diagnosis contrary to the original diagnosis of clear cell chondrosarcoma that was suggested by radiology. (
  • The histopathological study of the biopsy specimen confirmed the diagnosis of basal cell carcinoma. (
  • Focuses on the diagnosis of an invasive noduloulcerative basal cell carcinoma. (
  • Transrectal needle biopsy, often guided by ultrasound, is useful to confirm the diagnosis, although incidental carcinomas can be found in transurethral resections for nodular hyperplasia. (
  • We report herein the unusual case of a man who was diagnosed as having sporadic medullary thyroid carcinoma (MTC) at the age of 29 years, and subsequently followed up for a period of 18 years. (
  • Hazard JB, Hawk WA, Crile G Jr (1959) Medullary (solid) carcinoma of the thyroid. (
  • Bussolati G, Monga G (1979) Medullary carcinoma of the thyroid with atypical patterns. (
  • Nieuwenhuijzen Kruseman AC, Bosman FT, van Bergen Henegouw JC, Cramer-Knijnenburg G, Brutel de la Riviere G (1982) Medullary differentiation of anaplastic thyroid carcinoma. (
  • Martinelli G, Bazzocchi F, Govoni E, Santini D (1983) Anaplastic type of medullary thyroid carcinoma. (
  • Kakudo K, Miyauchi A, Katayama S, Watanabe K (1987) Ultrastructural study of poorly differentiated medullary carcinoma of the thyroid. (
  • Baschieri I, Ronga G, Fiorentino A, Mariani P, Carlei F (1990) Thyroid carcinoma with biphasic clinical course and evolution in medullary carcinoma-follicular variant. (
  • Carcinoma of the thyroid with a mixed medullary and follicular pattern. (
  • Medullary thyroid carcinoma with thyroglobulin immunoreactivity. (
  • Our previous study using proteomic profiling demonstrated significant up-regulation of Septin1, a conserved family of GTPase proteins, in oral squamous-cell carcinoma (OSCC)-derived cell lines. (
  • These include squamous cell or epidermoid carcinomas (the most common type worldwide), adenocarcinomas, and large cell carcinomas. (
  • In this study, the clinicopathologic characteristics of 38 resected OGCs were investigated and contrasted with 725 resected pancreatic ductal adenocarcinomas without osteoclastic cells (PDCs). (
  • An important gene associated with Lung Giant Cell Carcinoma is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling . (
  • Dhillon MS, Prasad P. Multicentric giant cell tumor of bone. (
  • Multicentric giant cell tumor of bone: ten lesions at presentation. (
  • 6. Rock MG. Curettage of giant cell tumor of bone. (
  • 7. Goldenberg RR, Campbell CJ, Bonfiglio M. Giant cell tumor of bone: an analysis of two hundred and eighteen cases. (
  • Denosumab and giant cell tumor of bone- a review and future management considerations. (
  • A giant cell tumor of bone is a benign, aggressive tumor that typically involves the distal femur, proximal tibia, and distal radius. (
  • Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib. (
  • For several decades, primary lung cancers were consistently dichotomously classified for treatment and research purposes into small-cell lung carcinomas (SCLCs) and non-small-cell lung carcinomas (NSCLCs), based on an oversimplified approach that is now clearly outmoded. (
  • Basal cell carcinoma accounts for approximately 80% of all skin cancers in the United States. (
  • Lung cancers are classified according to the type of cell present in the tumor. (
  • There is considerable evidence to suggest that the cell-in-cell phenomenon is associated with the prognosis of cancers, and it promotes tumor progression in most situations. (
  • Epigenetic alterations such as histone acetylation and DNA methylation play an important role in the regulation of gene expression for cell cycles and apoptosis that may affect the chemosensitivity of cancers. (
  • MetaPLASTIC carcinoma (of the breast) 37. (
  • At present, cumulative data on this rare histological variant is limited and the prognostic significance of the presence and the extent of a giant cell component in endometrial carcinoma remain uncertain. (
  • Giant basal cell carcinoma (BCC), defined as a lesion greater than 5 cm at its largest diameter, is a rare variant of BCC. (
  • The distinction between CCPRCC with variant morphology and clear cell RCC is critical because no case of CCPRCC has behaved aggressively. (
  • Maleki Z, Shariat S, Mokri M, Atri M. ER-negative /PR-positive Breast Carcinomas or Technical Artifacts in Immunohistochemistry? (
  • Giant cell tumour of bone. (
  • 1] Netscher DT, Spira M. Basal cell carcinoma: an overview of tumour biology and treatment. (
  • Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment. (
  • An epithelial neoplasm characterized by unusually large anaplastic cells. (
  • The immunohistochemical studies evidenced no reactivity of osteclast-like giant cells to epithelial markers but showed a positive reactivity to histiocytic markers. (
  • Imprint cytology of the biopsied sample displayed cellular epithelial nests with focal acinar structures and foci composed of larger cells with a low nuclear/cytoplasmic ratio. (
  • Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule antibody against pancreatic carcinoma. (
  • However, in current thinking, the prognosis of breast carcinoma with OGCs is considered to be related to the tumoural histology, and not influenced by the presence of OGCs [ 1 ]. (
  • Macrophage plasticity responding microenvironments is discussed, in relation to prognosis of breast carcinoma. (
  • papillary carcinomas have the best prognosis. (
  • High Ki-67 Immunohistochemical Reactivity Correlates With Poor Prognosis in Bladder Carcinoma: A Comprehensive Meta-Analysis with 13,053 Patients Involved. (
  • She had Giant Basal Cell Carcinoma for many years on scalp and its diameters was 16x12 cm. (
  • Giant superficial BCC arising on the scalp is extremely rare. (
  • We report the case of giant superficial BCC with four satellite lesions on the scalp in a 53-year-old male without predisposing factors . (
  • We are presenting a case of basal cell carcinoma invading and eroding occipital bone, managed with an unusual scalp reconstruction method. (
  • Ultrastructurally, the characteristic secretory granules in the neoplastic cells decreased remarkably in number, consistent with the immunohistochemical findings. (
  • Microcystic adnexal carcinoma: an immunohistochemical reappraisal. (
  • Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain. (
  • Aggressive basal cell carcinoma: presentation, pathogenesis, and management. (
  • Fine-needle aspiration and core needle biopsy demonstrated invasive ductal carcinoma with multi-nucleated OGCs. (
  • It is unusual to find a giant invasive basal cell carcinoma in the occipital region of the head. (
  • Invasive basal cell carcinoma causing skull and dura destruction. (
  • On microscopic examination, a well-differentiated invasive squamous cell carcinoma composed of cells that resemble those of the normal squamous epithelium is shown. (
  • see neoplasm neoplasm or tumor, tissue composed of cells that grow in an abnormal way. (
  • The undifferentiated carcinoma is a rare and aggressive form of pancreatic neoplasm. (
  • BACKGROUND: Pancreatoblastoma (PBL) is a rare neoplasm that generally occurs in the pediatric age group and shows unique histopathology, including squamoid corpuscles that may contain tumor cells with optically clear nuclei (OCN) rich in biotin. (
  • 1,2) More than 90% of PPCs are papillary serous carcinomas. (
  • Bagby C, Ronnett BM, Yemelyanova A, Maleki Z, Kuhn E, Vang R. Clinically occult tubal and ovarian high-grade serous carcinomas presenting in uterine samples: diagnostic pitfalls and clues to improve recognition of tumor origin. (
  • These granules also diminished in diameter and intracytoplasmic small lumina and intercellular clefts with microvilli, interpreted as an attribute of anaplastic thyroid carcinomas, were frequently observed in tissues obtained after his clinical deterioration or at postmortem sampling. (
  • It was unknown that this was an actionable target in ibrutinib-resistant cell lymphoma. (
  • Talk about this article with other patients, caregivers, and advocates in the Mantle Cell Lymphoma CURE discussion group. (
  • Clinical and radiological features of atypical giant cell tumours of bone. (
  • Giant Cell Carcinoma of Endometrium: a Rare Clinical Entity', Iranian Journal of Pathology , 7(3), pp. 197-202. (
  • From a clinical, radiographic, and pathologic perspective, metastases and primary pulmonary carcinomas far exceed the incidence of primary pulmonary sarcomas. (
  • Basal cell carcinoma and squamous cell carcinoma are common entities in clinical practice. (
  • Correlate specific in vivo parameters of immune response (post-vaccination delayed-type hypersensitivity reactions to autologous tumor, mesothelin-specific T-cell response, and the degree of local eosinophil, macrophage, and T-cell infiltration at the vaccine site) with clinical responses in patients treated with this regimen. (
  • Spindle cell carcinoma of kidney, pelvis, ureter 20. (
  • Squamous cell carcinoma of the vulva progresses through similar stages as squamous cell carcinoma of the cervix and vagina. (
  • The ileal segment and uterus/cervix were spared but urethral and radial surgical margins were positive for tumor cells. (
  • Giant cell carcinoma is a non-small cell carcinoma solely comprising anaplastic, giant tumor cells (Figure 2, D). (