Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cytochrome P-450 CYP2D6: A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population.Cytochrome P-450 CYP1A2: A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.Cytochrome P-450 CYP1A1: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.New York CityCandidiasis, Invasive: An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.Communicable DiseasesCellular Phone: Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.Professional Practice Location: Geographic area in which a professional person practices; includes primarily physicians and dentists.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Physicians: Individuals licensed to practice medicine.Zygoma: Either of a pair of bones that form the prominent part of the CHEEK and contribute to the ORBIT on each side of the SKULL.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)Alkylating Agents: Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Orphan Drug Production: Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Cell Line, Tumor: A cell line derived from cultured tumor cells.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.United StatesHistory, 18th Century: Time period from 1701 through 1800 of the common era.History, 19th Century: Time period from 1801 through 1900 of the common era.History, 20th Century: Time period from 1901 through 2000 of the common era.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Naval Medicine: The practice of medicine concerned with conditions affecting the health of individuals associated with the marine environment.Glossectomy: Partial or total surgical excision of the tongue. (Dorland, 28th ed)Tongue Neoplasms: Tumors or cancer of the TONGUE.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Ultrasonic Surgical Procedures: The use of HIGH-ENERGY SHOCK WAVES, in the frequency range of 20-60 kHz, to cut through or remove tissue. The tissue fragmentation by ultrasonic surgical instruments is caused by mechanical effects not heat as with HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Social Sciences: Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.ChicagoOncology Service, Hospital: The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cancer patient.Pyrimidine Nucleosides: Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES.Exhibits as Topic: Discussions, descriptions or catalogs of public displays or items representative of a given subject.Persons: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Pyrimidine Phosphorylases: Pentosyltransferases that catalyze the reaction between a pyrimidine nucleoside and orthophosphate to form a free pyrimidine and ribose-5-phosphate.Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.Purine Nucleosides: Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES.Pyrimidine Nucleotides: Pyrimidines with a RIBOSE and phosphate attached that can polymerize to form DNA and RNA.Uridine Phosphorylase: An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Polyglutamic Acid: A peptide that is a homopolymer of glutamic acid.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.Pteroylpolyglutamic Acids: Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.Folic Acid Antagonists: Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)Folic Acid: A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (POACEAE). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.gamma-Glutamyl Hydrolase: Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid and free glutamic acid. EC 3.4.19.9.Tetrahydrofolates: Compounds based on 5,6,7,8-tetrahydrofolate.Ascites: Accumulation or retention of free fluid within the peritoneal cavity.Dermatoglyphics: The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Diving: An activity in which the organism plunges into water. It includes scuba and bell diving. Diving as natural behavior of animals goes here, as well as diving in decompression experiments with humans or animals.Health Services Research: The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Biometric Identification: A method of differentiating individuals based on the analysis of qualitative or quantitative biological traits or patterns. This process which has applications in forensics and identity theft prevention includes DNA profiles or DNA fingerprints, hand fingerprints, automated facial recognition, iris scan, hand geometry, retinal scan, vascular patterns, automated voice pattern recognition, and ultrasound of fingers.Recycling: The extraction and recovery of usable or valuable material from scrap or other discarded materials. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed.)GlutaminaseIsoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Antiperspirants: Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS).Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.Diazooxonorleucine: An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)Parenteral Nutrition Solutions: Specialized solutions for PARENTERAL NUTRITION. They may contain a variety of MICRONUTRIENTS; VITAMINS; AMINO ACIDS; CARBOHYDRATES; LIPIDS; and SALTS.Methylmethacrylate: The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.

The interaction of rhodium(II) carboxylates with enzymes. (1/1023)

The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irreversibly inhibited. Those enzymes without essential sulfhydryl groups were not affected. In each case, the rate of inactivation closely paralleled the observed toxicity and antitumor activity of rhodium(II) carboxylates; that is, rhodium(II) propionate greater than rhodium(II) acetate greater than rhodium(II) methoxyacetate. In addition, those enzymes that have been demonstrated to be most sensitive to established sulfhydryl inhibitors, such as glyceraldehyde-3-phosphate dehydrogenase, were also most sensitive to rhodium(II) carboxylate inactivation. Proton nuclear magnetic resonance measurements made during the titration of rhodium(II) acetate with cysteine showed that breakdown of the carboxylate cage occurred as a result of reaction with this sulfhydryl-containing amino acid.  (+info)

Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (2/1023)

The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties.  (+info)

Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells. (3/1023)

A monoclonal antibody (mAb; A10) raised against murine Ehrlich tumor cell surface carbohydrates was tested for reactivity with human normal and malignant tissues. A10 reacted strongly, with a high proportion of adenocarcinomas arising from colon and other tissues but not with breast carcinomas or other malignant tumors. Normal tissues were virtually A10 unreactive, except for the duct cells from breast and pancreas and some bronchial mucosae. Ultrastructural studies showed mAb A10 immunolabeling of both microvilli and mucin droplets in colon cancer cells but not in normal absorptive or globet cells. A10 reacted strongly with mucin-enriched fractions from colon cancer tissues and HT-29 xenografts but not from normal colon tissues. A10 epitope was carried on MUC1 derived from colon adenocarcinomas and probably on other mucin species, although not on MUC2 molecules. A10 epitope was resistant to exoglycosidases and periodate oxidation but sensitive to the Smith's degradation and beta-elimination, suggesting the involvement of O-linked carbohydrates in nonterminal reducing positions. A mucin-type glycosidic linkage was supported because of the lack of A10 reactivity with HT-29 cells grown with phenyl-N-acetyl-alpha-D-galactosaminide. Deglycosylation studies with trifluoromethanesulfonic acid pointed to the involvement of core mucin glycans in the A10 epitope. This epitope was resistant to protease, O- and N-glycanase treatments carried out on trifluoromethanesulfonic acid-deglycosylated mucins. Inhibition studies with core 1, core 2, core 3, and core 6 suggested the latter [GlcNAcbeta(1-6)GalNAc] as being involved in A10 epitope. Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer.  (+info)

Phospholipid metabolism in ehrlich ascites tumor cells. II. Turnover rate of ether phospholipids. (4/1023)

1. Radioactive precursors of phospholipids, i.e., 32Pi, [1-14C]glycerol, [2-3H]glycerol, and [1-14C]acetate, were individually injected into the peritoneal cavity of mice bearing Ehrlich ascites tumor cells and the rates of incorporation were estimated. 2. Although [2-3H]glycerol was not practically incorporated into ether phospholipids, the other three radioactive precursors were incorporated into diacyl, 1-O-alkenyl-2-acryl-, and 1-O-alkyl-2-acryl-GPE (GPC). 3. In the experiments on 32Pi or [1-14C]acetate incorporation, 1-O-alkyl compounds in the ethanolamine phosphoglyceride fraction showed high specific activities in comparison with 1-acyl compounds. In the case of [1-14C]glycerol incorporation, a high rate of incorporation into 1-O-alkyl compounds was not found. In the choline phosphoglyceride fraction, a high rate of incorporation of the above precursors into 1-O-alkyl compounds was not observed. 4. The specific activities of 1-O-alkenyl compounds were fairly low compared with those of 1-acyl- and 1-O-acyl- and 1-O-alkyl compounds throughout the incorporation experiments with [1-14C]glycerol and [1-14C]acetate, but in 32Pi incorporation, 1-O-alkenyl compounds showed higher specific activities than 1-acyl compounds in ethanolamine phosphoglyceride, suggesting an exchange reaction of the phosphorylethanolamine moiety. 5. From the above findings, it appears that alkyl ether phospholipids of ethanolamine from may have a significant role in ascites tumor cells, based on their rapid turnover.  (+info)

Isolation of ekatetrone, a new metabolite of producing variants of Streptomyces aureofaciens. (5/1023)

From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of Ehrlich's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis.  (+info)

New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies. (6/1023)

A new semisynthetic anti-tumour bis-indol compound, KAR-2 [3'-(beta-chloroethyl)-2',4'-dioxo-3,5'-spiro-oxazolidino-4-dea cetoxy-vinblastine] with lower toxicity than vinca alkaloids used in chemotherapy binds to calmodulin but, in contrast to vinblastine, does not exhibit anti-calmodulin activity. To investigate whether the modest chemical modification of bis-indol structure is responsible for the lack of anti-calmodulin potency and for the different pharmacological effects, new derivatives have been synthesized for comparative studies. The synthesis of the KAR derivatives are presented. The comparative studies showed that the spiro-oxazolidino ring and the substitution of a formyl group to a methyl one were responsible for the lack of anti-calmodulin activities. The new derivatives, similar to the mother compounds, inhibited the tubulin assembly in polymerization tests in vitro, however their inhibitory effect was highly dependent on the organization state of microtubules; bundled microtubules appeared to be resistant against the drugs. The maximal cytotoxic activities of KAR derivatives in in vivo mice hosting leukaemia P388 or Ehrlich ascites tumour cells appeared similar to that of vinblastine or vincristine, however significant prolongation of life span could be reached with KAR derivatives only after the administration of a single dose. These studies plus data obtained using a cultured human neuroblastoma cell line showed that KAR compounds displayed their cytotoxic activities at significantly higher concentrations than the mother compounds, although their antimicrotubular activities were similar in vitro. These data suggest that vinblastine/vincristine damage additional crucial cell functions, one of which could be related to calmodulin-mediated processes.  (+info)

Heterogeneity of native ribosomal 60-S subunits in Ehrlich ascites tumor cells cultured in vitro. (7/1023)

Native large ribosomal subunits in cultured Ehrlich ascites tumor cells analyzed by high-resolution CsCl isopycnic centrifugation consist of at least two classes of particles with densities of 1.57 g/cm3 (LI) and 1.59 g/cm3 (LII), respectively. A wash with 0.5 M KCl converts LI into particles with the density of LII particles. Incubation of derived large subunits (density 1.59 g/cm3) with 0.5 M KCl wash of reticulocyte ribosomes leads to the formation of particles with the density of LI particles. A protein with a molecular weight of 57000 present in the high-KCl wash of 60-S native subunits was virtually absent in the KCl wash of 40-S subunits or polyribosomes suggesting that specific protein factors may be present on some native 60-S subunits. Possible functions of these protein factors are discussed.  (+info)

Glyceraldehyde-3-phosphate dehydrogenase from Ehrlich ascites carcinoma cells its possible role in the high glycolysis of malignant cells. (8/1023)

Glyceraldehyde-3-phosphate dehydrogenase has been purified to apparent homogeneity from Ehrlich ascites carcinoma (EAC) cells. The enzyme is quite active over a pH range of 7.5-9.0 with an optimum pH of 8.4-8.7. The specific activity of the enzyme is much higher than that from other normal sources. In contrast to enzyme obtained from rabbit muscle, the EAC cell enzyme is not significantly inhibited by physiological concentrations of ATP at physiological pH. Kinetic studies using different substrates and inhibitors indicate that the properties of the EAC cell enzyme are significantly different from those of glyceraldehyde-3-phosphate dehydrogenase obtained from other normal sources. The striking dissimilarity of the malignant cell glyceraldehyde-3-phosphate dehydrogenase compared with this enzyme from other normal sources, particularly in respect to the interaction with ATP, may in part explain the high glycolysis of malignant cells.  (+info)

*Katarína Horáková

"Sacharose density gradient separation of Ehrlich ascites carcinoma and L-5178Y tumor cells in different cell cycle phases". ... Interference of Bruneomycin with the Cell Cycle of Ehrlich's Ascites Carcinoma]. Biológia (in Slovak). 35 (12): 875-80. ... Horáková, K (1975). "Ribonucleases in mouse ascitic tumor cells during ageing in vivo and in vitro". Advances in experimental ... Horáková, K (1972). "Polynucleotidases in mouse ascitic tumour cells". Neoplasma. 19 (5): 459-68. PMID 4345214. Fuska, JAN; ...

*Ehrlich ascites carcinoma

Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an ascites tumor in mice ... The tumor was cultured in vivo, which became known as the Ehrlich cell. After 1948 Ehrlich cultures spread around research ... "Osmotic properties of ehrlich ascites tumor cells during the cell cycle - Dupre - 2005 - Journal of Cellular Physiology - Wiley ... Dupre, Ann M.; Hempling, H. G. (December 1978). "Osmotic properties of ehrlich ascites tumor cells during the cell cycle". ...

*Pterocarpus indicus

This property might be due to an acidic polypeptide found in its leaves that inhibited growth of Ehrlich ascites carcinoma ... In folk medicine, it is used to combat tumors. ...

*Fawzia Fahim

Mady, E. A. (2002). "Antitumor and biochemical effects of Echis coloratus crude venom on Ehrlich ascites carcinoma cells in ... "Role of dietary magnesium and/or manganese variables on ehrlich ascites tumor‐bearing mice". Nutrition and Cancer. 12 (3): 279- ... "Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ...

*Sp1 transcription factor

"Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 ... "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". J. Biol. Chem. 278 ...

*List of MeSH codes (C04)

... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ... carcinoma, signet ring cell MeSH C04.557.470.200.025.415.410 --- krukenberg tumor MeSH C04.557.470.200.025.420 --- carcinoma, ... carcinoma, krebs 2 MeSH C04.557.470.200.260 --- carcinoma, large cell MeSH C04.557.470.200.280 --- carcinoma, lewis lung MeSH ... mixed tumor, malignant MeSH C04.557.435.530 --- mixed tumor, mesodermal MeSH C04.557.435.540 --- mixed tumor, mullerian MeSH ...

*Iodoacetic acid

"Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ... Apffel, C. A.; Arnason, B. G.; Peters, J. H. (1966). "Induction of tumour immunity with tumour cells treated with iodoacetate ... Several studies have shown iodoacetate has anti-tumor effects. In 2002 Dr. Fawzia Fahim showed that "a single IAA treatment of ... In 1966 Charles A. Apffel, Barry G. Arnason & John H. Peters showed anti-tumor activity for iodoacetate. Iodide is a naturally ...

*Stuart A. Aaronson

His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming ... Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/ ... 1982 Rhoads Memorial Award 1982 PHS Meritorious Service Medal 1989 Paul Ehrlich Award 1989 PHS Distinguished Service Medal 1990 ... "Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma". ...

*Aflatoxin B1

These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... Prevalence of hepatocellular carcinoma in individuals exposed to aflatoxin, increases with co-infection of hepatitus B virus. ... Yu J, Chang PK, Ehrlich KC, et al. (March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol ... Up to 44% of hepatocellular carcinomas in regions with high aflatoxin exposure bear a GC → TA transversion at codon 249 of p53 ...

*Hsp27

... thereby promoting tumor cell proliferation. As a result, tumor vaccine strategies for Hsp70s have been highly successful in ... Changes of Hsp27 levels were observed in Ehrlich ascite cells, embryonic stem cells, normal B-cells, B-lymphoma cells, ... In particular, overexpression of HSP72 has been linked to the development of some cancers, such as hepatocellular carcinoma, ... Elevated Hsp70 levels in tumor cells may increase malignancy and resistance to therapy by complexing, and hence, stabilizing, ...

*Hans Georg Rammensee

Since the late 1970s, Rammensee has been focusing on immunology with the specific aim of using tumor immunology to fight ... 2013 Paul Ehrlich and Ludwig Darmstaedter Prize, 1996 Robert Koch Prize, 1993 Gottfried Wilhelm Leibniz Prize, 1992 Heinz Maier ... The immunopeptidomic landscape of ovarian carcinomas. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9942-E9951. doi: 10.1073/ ... Rammensee has contributed essentially to the research fields of MHC biology and tumor immunology and to the development of ...

*IRF8

... but is significantly focally deleted across the entire dataset of 3131 tumors, suggesting that IRF8 is potentially a tumor ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (June 1995). "Functional domain analysis of interferon ... Molecular analysis indicated that the IRF8 gene promoter is hypermethylated in human colon carcinoma cells, suggesting that ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus ...

*Microsatellite instability

MSI-L tumors result from less than 30% of unstable MSI biomarkers. MSI-L tumors are classified as tumors of alternative ... MSI has been evident in the cause of sebaceous carcinomas. Sebaceous carcinomas are a subset of a larger pathology, Muir-Torre ... Ehrlich, Melanie, ed. (2000). DNA alterations in cancer: genetic and epigenetic changes. Natick, MA: Eaton Publ. p. 178. ISBN ... MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors ...

*Harald zur Hausen

This paid off several years later in 1983 when zur Hausen identified HPV 16 DNA in cervical cancer tumors by Southern blot ... M Dürst; L Gissmann; H Ikenberg; H zur Hausen (1983-06-01). "A papillomavirus DNA from a cervical carcinoma and its prevalence ... Robert Koch Prize (1975) Charles S. Mott Prize (1986) Paul-Ehrlich-und-Ludwig-Darmstaedter-Preis (1994) Virchow Medal from the ... Coley Award for Distinguished Research in Basic and Tumor Immunology in 2006 (with Ian Frazer) AACR Award for Lifetime ...

*S100A6

"Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding ... S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma. GRCh38: Ensembl release 89: ENSG00000197956 ... "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid ... carcinoma". Thyroid. 20 (10): 1067-76. doi:10.1089/thy.2009.0400. PMID 20629554. Schäfer BW, Heizmann CW (1996). "The S100 ...

*Charlotte Friend

... the two decided to look at fine structures within the cells of the Ehrlich ascites carcinoma, a commonly used model for cancer ... "The Coming of Age of Tumor Virology." Cancer Research 37 (1977): 1255-1263 "Hemoglobin Synthesis in Murine Virus-induced ...

*FGF8

Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is ... Gemel J, Gorry M, Ehrlich GD, MacArthur CA (1996). "Structure and sequence of human FGF8". Genomics. 35 (1): 253-7. doi:10.1006 ... isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". ... This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. ...

*RAGE (gene)

"Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas". Applied ... Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A (May ... Götte K, Usener D, Riedel F, Hörmann K, Schadendorf D, Eichmüller S (July 2002). "Tumor-associated antigens as possible targets ... "Entrez Gene: RAGE renal tumor antigen". Eichmüller S, Usener D, Jochim A, Schadendorf D (August 2002). "mRNA expression of ...

*Christian Bréchot

Hepatitis C virus core variants isolated from liver tumor but not from adjacent non tumor interact with Smad3 and inhibit the ... doi: 10.1002/hep.24087 ARUMUGAM M, RAES J, …… , BRECHOT C, MERIEUX A, …… , WEISSENBACH J, EHRLICH SD, BORK P. Enterotypes of ... hepatocellular carcinoma, HCC), as well as the molecular mechanisms underpinning liver regeneration and cancer (especially the ... to treat hepatocellular carcinoma. Christian Bréchot is a member of several specialized French and international medical ...

*RBBP8

It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants ... Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni- ... in breast carcinomas". Int. J. Cancer. 107 (1): 155-8. doi:10.1002/ijc.11343. PMID 12925972. Dick FA, Sailhamer E, Dyson NJ ( ... "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. ...

*Ras subfamily

Another tumor-lysing virus that specifically targets tumor cells with an activated Ras pathway is a type II herpes simplex ... Rotblat B, Ehrlich M, Haklai R, Kloog Y (2008). "The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the ... Parada LF, Tabin CJ, Shih C, Weinberg RA (June 1982). "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ... The tumour suppressor gene NF1 encodes a Ras-GAP - its mutation in neurofibromatosis will mean that Ras is less likely to be ...

*Rudolf Virchow

It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... Experiment also shows that drugs that block inflammation simultaneously inhibit tumour formation and development. Virchow was ... and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic pathology there. One of Virchow's ... First described by Karl Thiersch in the 1860s.) But he made a crucial observation that certain cancers (carcinoma in modern ...

*CDKN1B

In ovarian cancer, p27 negative tumors progressed in 23 months compared to 85 months in p27 positive tumors and thus could be ... In hepatocellular carcinoma cells p27 co-localizes with actin fibers to act on GTPase Rac and induce cell migration. In breast ... Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI (November 2000). "Disruption of TGF-beta growth ... In most cancers reduced levels of nuclear p27 are correlated with increased tumor size, increased tumor grade, and a higher ...

*Ludwik Gross

... (September 11, 1904 - July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses, ... Principal 1978 Paul Ehrlich-Ludwig Darmstaeder Prize in Frankfurt Griffuel Prize in Paris (1978). Elected to the National ... murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. ...

*Uridine monophosphate synthetase

... monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'- ... "Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil". ... "Effect of 5-phosphoribosyl-a-pyrophosphate on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells made permeable ... phosphate decarboxylase enzyme complex from mouse Ehrlich ascites cells". The Journal of Biological Chemistry. 254 (4): 1143-50 ...

*Lactococcus lactis

Another study, lead by Zhang B, created a L.lactis strain that maintains a plasmid containing a tumor metastasis-inhibiting ... CS1 maint: Multiple names: authors list (link) Bolotin, A., Quinquis, B., Renault, P., Sorokin, A., Ehrlich, S. D., Kulakauskas ... Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT ...
in European Journal of Cell Biology (1988), 47(2), 346-57. In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU ... [more ▼]. In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU) monoclonal antibody have been applied. In both cases, the immunogold labeling has been performed on ultrathin sections of cells embedded either in Lowicryl K4M or in Epon, respectively. Identical results are observed with both immunocytochemical approaches. In the interphase nucleolus, besides the labeling of the perinucleolar chromatin shell and of its intranucleolar invaginations which penetrate into the nucleolar body and often terminate at the fibrillar centers, a few gold particles are also preferentially found towards the peripheral ...
BioAssay record AID 118144 submitted by ChEMBL: Effect of compound on Ehrlich ascites carcinoma growth in CF1 mice at a dose ((20 mg/kg)/day) ip survival at day 9 packed cell volume as a percent.
en] Here we describe a new, rapid method for isolating nucleoli from Ehrlich tumor cells that preserves their morphological integrity and high transcriptional activity. Until now, methods for isolation of nucleoli were generally assumed to empty one of their three main compartments, the fibrillar center, of its contents. This new method consists of sonicating cells in an isotonic medium containing MgSO(4), spermidine, and spermine, followed by separation of nucleoli through a Percoll density gradient. Using the nonisotopic approach of labelling with BrUTP, we have further investigated the dynamics of nascent ribosomal RNAs (rRNAs) within morphologically intact isolated nucleoli at the electron microscope level. We show that ribosomal transcripts are elongated in the cortex of the fibrillar center and then enter the surrounding dense fibrillar component ...
Ca2+ uptake into Ehrlich ascites tumor cells was studied at 0°C in the presence of mitochondrial inhibitors, conditions that minimized complications caused by sequestration of Ca2+ into organelles or by excretion. Under these conditions Ruthenium Red inhibited Ca2+ uptake, but other previously implicated ions, such as Pi or Mg2+, had no effect. Valinomycin either inhibited or slightly stimulated Ca2+ uptake depending on the presence of excess K+ on the outside or inside of the cell, respectively. Nigericin inhibited Ca2+ transport. Based on these data we propose an electrogenic uptake of Ca2+, possibly via a Ca2+/H+ antiport mechanism. The observation that glucose inhibited Ca2+ uptake suggested that in Ehrlich ascites tumor cells an energy-driven Ca2+ expulsion mechanism is operative, similar to that in erythrocytes. Plasma membrane preparations of ascites tumor cells were found to contain a Ca2+-dependent ATPase. These preparations, when incorporated into liposomes in an inside-out orientation,
1. The formation of adenosine 5-phosphate, guanosine 5-phosphate and inosine 5-phosphate from [8-(14)C]adenine, [8-(14)C]guanine and [8-(14)C]hypoxanthine respectively in the presence of 5-phosphoribosyl pyrophosphate and an extract from Ehrlich ascites-tumour cells was assayed by a method involving liquid-scintillation counting of the radioactive nucleotides on diethylaminoethylcellulose paper. The results obtained with guanine were confirmed by a spectrophotometric assay which was also used to assay the conversion of 6-mercaptopurine and 5-phosphoribosyl pyrophosphate into 6-thioinosine 5-phosphate in the presence of 6-mercaptopurine phosphoribosyltransferase from these cells. 2. At pH 7.8 and 25 degrees the Michaelis constants for adenine, guanine and hypoxanthine were 0.9 mum, 2.9 mum and 11.0 mum in the assay with radioactive purines; the Michaelis constant for guanine in the spectrophotometric assay was 2.6 mum. At pH 7.9 the Michaelis constant for 6-mercaptopurine was 10.9 mum. 3. 25 mum-6
en] The cellular effects of dihydroflavopereirine and sempervirine ( two alkaloids isolated from Loganiaceae) are analysed by cytological methods in experimental tumours cultivated in vitro ( B16 mouse melanoma cells, mouse Ehrlich tumour cells ELT). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated and related to the molecular structure ...
A comparison of the cytidine 5′-diphosphate (CDP) and adenosine 5′-diphosphate (ADP) reductase activities from Ehrlich tumor cells was made to determine if the properties of the enzyme for these substrates were the same, except for the allosteric effector. It was observed that various purification steps did not result in an enzyme fraction that had a constant ratio of CDP:ADP reductase activities. The optimal Mg2+ ion concentration for CDP reduction was 3 to 4 mm, while the optimal Mg2+ ion concentration for ADP reduction was 0.1 mm. Concentrations of Mg2+ ions greater than 0.1 mm inhibited ADP reduction. CDP reduction was relatively insensitive to the presence of dimethylformamide or dimethyl sulfoxide in the reaction mixture, but ADP reduction was decreased in the presence of these two compounds. Periodate-oxidized adenosine 5′-monophosphate, on incubation with the enzyme, had a greater effect on CDP reduction but little or no effect on ADP reduction. The response of the CDP and ADP ...
INTRODUCTION: Fluoroacetate (FA) is a highly toxic metabolic poison found in eight species of plants - including Dichapetalum and Gastrolobium - growing in Australia, South and Central Africa and South America. The level of FA in some plants can reach up to 5 g kg-1 dry weight and can cause death of livestock and domestic animals. Moreover, FA can be found in fog and rain-drops in some industrial regions. The best known representative of FA is its sodium salt (SFA, compound 1080), which is used in several countries for controlling populations of some vertebrates. Although extremely toxic, FA has positive properties: it can prevent development of tolerance to morphine, and has radioprotective power due to its capacity to reduce body temperature and oxygen consumption. OBJECTIVES: To evaluate the antitumor properties of SFA in monotherapy regime and in combination with a known antitumor compound. MATERIALS AND METHODS: Mice bearing Ehrlich tumor carcinoma were treated daily with SFA, 1.25mg/kg ...
Lassen, U; Nielsen, A; Pape, L; and Simonsen, L, "The membrane potential of ehrlich ascites tumor cells, microelectrode measurements and their critical evaluation." (1971). Subject Strain Bibliography 1971. 2022 ...
Simonsen, L O. and Cornelius, F, "Inorganic phosphate in ehrlich ascites tumor cells and its distribution across the cell membrane." (1978). Subject Strain Bibliography 1978. 3326 ...
Treatment of the 1-day-old Ehrlich ascites tumor with combinations of selected doses of l-asparaginase and the l-glutamine antagonist, 6-diazo-5-oxo-l-norleucine, or of the l-glutamine acid antagonist, dl-methionine-dl-sulfoximine, produced significantly more growth inhibition without a marked increase in host toxicity than did treatment with l-asparaginase administered alone. In the 3-day-old tumor treated with the combination of l-asparaginase and 6-diazo-5-oxo-l-norleucine, there was a significant enhancement of growth inhibition as compared with the effect of either drug used alone. A less significant increase of growth inhibition was obtained with combination of l-asparaginase and l-glutamyl-γ-hydrazide as compared with the effect of this chemical administered alone.. Combinations of l-asparaginase and 6-diazo-5-oxo-l-norleucine produced increased antitumor effects in mouse melanoma B16 and to a lesser degree in the solid form of Ehrlich tumor and Walker carcinosarcoma 256 of the ...
TY - JOUR. T1 - N-Bromoacetyl-β-D-glucosamine tetra-O-acetate and N-bromoacetyl-β-D-galactosamine tetra-O-acetate as chemotherapeutic agents with immunopotentiating effects in Ehrlich ascites tumor-bearing mice. AU - Simon, P.. AU - Burlingham, W. J.. AU - Conklin, R.. AU - Fondy, Thomas P. PY - 1979. Y1 - 1979. N2 - N-Bromoacetyl-β-D-glucosamine tetra-O-acetate (NBrAcGlc-TA) and N-bromoacetyl-β-D-galactosamine tetra-O-acetate (NBrAcGal-TA) produced strong in vitro cytotoxicity against both Ehrlich and L1210 leukemia dividing cell lines at μM concentrations. A single administration i.p. at one-half the dose lethal to 10% of the animals of either agent cured 85% of Ehrlich ascites tumor-bearing C57BL/6J x DBA/2 (hereafter called B6D2F1) mice. Animals immunosuppressed by prior X-irradiation could not be cured by these agents. The corresponding chloro and fluoroderivatives and the non-O-acetylated N-haloacetylhexosamines were inactive in vitro and in vivo. No significant effect against L1210 ...
Glutathione metabolism was studied in cancer cells during the growth of an Ehrlich ascites tumour. GSH, but not GSSG, content decreases when cell proliferation and the rate of protein synthesis in the tumour decrease. This change correlates with a decrease in the rate of GSH synthesis and an increase in glutathione peroxidase and glutathione S-transferase activities. Glutathione efflux from tumour cells seems to co-ordinate with the rate of GSH synthesis. Cysteine, and not methionine, promotes GSH synthesis in tumour cells. However, changes in the rate of GSH synthesis are not due to limitations in the supply of blood cysteine or to changes in the intracellular amino acid pool of the cancer cells. Our data suggest that changes in protein metabolism accompanying tumour growth in vivo can modulate glutathione content in cancer cells. ...
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We have developed a simple and rapid method for isolation of purified nuclear lamina from Ehrlich ascites tumor cells. The procedure employs chromatin structures prepared from whole cells at low ionic strength and is carried out under conditions that minimize the formation of artifactual... mehr ...
4,4-Diisothiocyano-2,2-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger. Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), "Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS", Journal of Membrane Biology, 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658 Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), "Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster", Biology of Reproduction, 61 (2): 452-457, doi:10.1095/biolreprod61.2.452, PMID 10411526 ...
A novel protein target of mouse calcyclin (S100A6) was detected by a gel overlay method with 125I-labelled calcyclin. Interaction of calcyclin with its 30 kDa target protein (p30) present in Ehrlich ascites tumour (EAT) cells depended on the presence of Ca2+ ions. The binding of p30, evidenced by the reaction with 125I-labelled calcyclin, was found to be of higher affinity than the binding between mouse calcyclin and annexin II or glyceraldehyde-3-phosphate dehydrogenase. Examination of tissue extracts by the gel overlay method has shown that p30 is present not only in the EAT cells but also in mouse brain and spleen. This novel target protein of mouse calcyclin was purified to homogeneity from EAT cells by means of Phenyl-Sepharose chromatography, affinity chromatography and CM-cellulose chromatography. Purified p30 was digested with α-chymotrypsin and a partial amino acid sequence of one of the resulting peptides was established. A database search analysis revealed that the sequence is ...
Radiosenstitizing effects of combination of a minor groove DNA ligand, Hoechst-33342, with the glucose analogue and inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) have been investigated in Ehrlich ascites tumour (EAT) bearing mice following focal irradiation of the tumour with 60Co gamma-rays. Treatment-induced tumour growth delay and tumour free animal survival were evaluated as parameters of radiation response. Focal irradiation of the tumour with a single fraction of 10 Gy induced a moderate delay in tumour growth but did not lead to complete regression in any of the tumours. Intravenous administration of H-342 1 hr before irradiation enhanced radiation-induced growth delay in a dose dependent manner. Complete regression of the tumour was observed only at a dose of 10 mg/kg body wt, leading to a cure (tumour free survival for more than 100 days) rate of 55%. Administration of 2-DG (2 g/kg body wt; iv), immediately before irradiation significantly enhanced radiation-induced growth delay and ...
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Visit Healthgrades for information on Dr. Matthew Ehrlich, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
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Gov. Robert L. Ehrlich Jr. appointed three new members to the Maryland Real Estate Commission this month in a move that replaced the panels chairman and put the governors stamp on a board that
Access information about snakes, prevention advice and pest control services to protect your home and yard and your family with Ehrlich.
When looking for a job in the field of education in France one is asked to supply a lettre de motivation, as well as a letter describing ones profil et...
Access Points develops a new theory about how democratic institutions influence policy outcomes. Access Point Theory argues that the more points of access that institutions provide to interest groups, the cheaper lobbying will be, and, thus, the more lobbying will occur.
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Je tapé la première lettre dune certaine URL dans la fenêtre dadresse lorsque jai été interrompu. En regardant en arrière un instant plus tard, jai été surpris à ce que le navigateur avait pris je voulais visiter. Alors voici mon A, B, C devine navigateur, ce qui je pense dire quelque chose sur moi. Quels sont les vôtres? [A] De ndroid ... » See Ya ...
Our Ladys Childrens Hospital, Crumlin has apologised to 18 families who were wrongly identified as being at the centre of a contamination scare over a medical scope.
Introduction: Achillea fragrantissima extract has been used in folk medicine as an anticancer. The present study describes the antitumor activities of the extract and the flavonoid compounds and attempts to explain the mechanisms underlying these activities. Methods: The whole plant of A. fragrantissima was collected and ground to produce a fine powder which subjected to the maceration process. Step gradient elution was used using silica gel vacuum liquid chromatography (VLC). The fractions were compared by thin layer chromatography (TLC) and concentrated. Final purification was performed using Sephadex LH-20 to give three compounds cirsiliol, chrysosplenol D and cirsimaritin from F4 and one compound, eupatilin-7-methyl ether from F6. In this study, Ehrlichs ascites carcinoma (EAC) model was used as the model of cancer. Results: Achillea fragrantissima extract and its isolated methoxylated flavonoids significantly reduced the weight of tumor discs compared to EAC-control group. In addition,
Tumor cells intensely utilize glutamine as the major source of respiratory fuel. Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. In the present study, antitumor properties of acivicin in combination with glutaminase enzyme is reported. Acivicin along with E. coli glutaminase synergistically reduced in vitro proliferation and matrigel invasion of human MCF-7 and OAW-42 cells. Effects of single and combined treatments with acivicin and glutaminase on angiogenic factors were also analyzed in these cell lines. Co-administration of the treatment agents inhibits the release of VEGF and MMP-9 by cells in culture supernatant significantly than single agent treatments. The result suggests that combination of acivicin with glutaminase may provide a better therapeutic option than either of them given separately for treating human breast and ovarian cancer. However, further studies are required to be conducted in vivo for its confirmation ...
ehrlich et al Maximum Hand-Rail And Hand-Rung Coupling Forces In Children: The Effects Of Diameter: Handhold diameter affects childrens ability to hang on. Human Factors (revisions submitted). Human Factors . 2012. In Press. Ehrlich et al 1. Clinico-pathologic Findings Predictive Of Relapse In Children With Stage III Favorable Histology Wilms Tumor: The Importance Of Lymph Nodes J Clinical Oncology Ehrlich et al Pediatric applied trauma research network: a call to action. J Trauma. 2010 Nov;69(5):1304-1307 Special commentary published simultaneously in Journal of Pediatric Surgery and Journal of Trauma. Ehrlich et al Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: A report from the Childrens Oncology Group. Pediatr Blood Cancer. 2011 Jun 14. US Estimates of Hospitalized Children With Severe Traumatic Brain Injury: Implications for Clinical Trials. Pediatrics. 2011 Dec;129(1):e24-30. ...
Paul Ehrlich, founder and first president of the Zero Population Growth organization, was born in Philadelphia, Pennsylvania. He received a B.A. in zoology from the University of Pennsylvania in 1953 and an M.A. and Ph.D. from the University of Kansas in 1955 and 1957, respectively. He became a member of the faculty at Stanford University in 1959 and was named Bing Professor of Population Studies in 1976. He is a recipient of a MacArthur Foundation fellowship, and in 1990 he was awarded Swedens Crafoord Prize, created by the Royal Swedish Academy of Sciences to honor researchers in those disciplines not covered by the Nobel Prize. An expert in population biology, ecology, evolution, and behavior, Ehrlich has published more than 600 articles and scientific papers. He is perhaps best known for his environmental classic The Population Bomb (1968). Paul Ehrlich and his wife Anne began working together shortly after their marriage in 1954. Anne Ehrlich received her B.S. in biology from the ...
Meet Doctor Dion R Ehrlich. Here are his vitals: Hes board certified, specializing in Ophthalmology with expertise in this area. Doctor Ehrlich is a highly experienced doctor, with 35 years of practice in the field Highly regarded by his patients they rate him 4 out of 4 stars. They point out the time he spends with them. He has won Patients Choice Award. Is affiliated with a highly rated hospital. Graduated from George Washington University. He completed his fellowship at The Ohio State University in 1978. His average waiting time is 11 minutes. He accepts new patients. He has a number of insurance plans accepted. Use Vitals.com to examine Doctor Dion R Ehrlich from Philadelphia, Pennsylvania. See patient comments make an appointment or even let us help you to prepare for your visit. Vitals .com where doctors are examined.. ...
The challenge of virulent strains of salmonella.. Radiation induced detoxification of endotoxin (LPS) of Salmonella. Studied the macrophage activation by the detoxified LPS.. Prepared vaccine against ascites tumor cells by coupling the ascites cells(Sarcoma 180) to LPS and Con A through glutarladehyde. This vaccine offered 100% protection against the challenge of ascites tumor cells in mice.. Activation of macrophages by different microorganisms. Immobilisation of bacterial cells to hydrolyse proteins from trash fish.. Isolation and characterization of the marine bacteria for the production of omega three fatty acids and optimization of cultural conditions for production is being standardized. Bryonia plant extract was shown to have anticancer properties against MCS human mammary cancer cells in vitro, while there is no toxicity to normal cells. Established grape precooling and cold storage technology and developed packaging and palletization technology in India. Exported grapes in refer ...
Previous observations in cancer patients and tumor-bearing animals suggested that myeloid lineage cells were involved in tumor-induced immunosuppression. Expansion of immature myeloid cells or macrophage/monocytes with characteristics of immune suppressive cells has been described in patients with head and neck cancer (6), gastric cancer (7), in mice bearing most carcinomas: Lewis lung carcinoma (8), Ehrlich carcinoma (9, 22), mammary adenocarcinoma (23), chemically induced fibrosarcoma (24), and colon carcinoma (13, 14, 15). This expansion was associated with a decline in T cell responses; however, little is known regarding the mechanism by which immune-suppressive cells inhibit primary T cell activation.. In the present study, we investigated how Gr-1+ myeloid cells, isolated from MCA-26 tumor-bearing mice and enriched by fractionation, contribute to inhibition of CD3/CD28-induced T cell activation. Several findings can be drawn from our experiments. We demonstrated a quantitative increase in ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
central methylene group of bilirubin, first described by Dr. Ehrlich in [3, 4]. Serum bilirubin levels are frequently as high as 10 to 15 mg/dL and may be as . with Ehrlichs dimethylaminobenzaldehyde reagent to produce a pink colour, pigments react, therefore the concentration is termed total bilirubin (Table ...
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What kind of accounting is essential. Management accounting is made for internal clients like management and employees to help in the day to day functioning of the corporation. It may appear to be a complicated endeavor to many and not having applicable types could be one reason behind it. If you prepared the trust bookkeeping all on your own or together with the support of a lawyer, possess the trust accounting form assessed by means of a CPA before sending it to the beneficiaries. Accounting is a broad term that is utilized to define the monitoring and evaluation of a particular function, in order to maintain certain set of criteria for a company or business. Should you hunt for bookkeeping on the internet you may think of endless publications, articles, terms, and definitions. Though a probate accounting in California doesnt demand the preparation of some particular types or using any specific format, there are numerous pieces of advice you must put on your account. The accountants have some ...
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
Living on Earth November 02, 2007 If you ask Paul Ehrlich, a professor of population studies at Stanford University, hell tell you the new UN report on the state of the global environment is old news. Dr. Ehrlich talks with host Bruce Gellerman about overpopulation, famine, and climate change, and the urgent need for the human species to save itself from disasters of its own making. ...
The 49ers suffered a major blow during OTAs, as wide receiver Michael Crabtree suffered what could be a season-ending injury. According to Mike Garafolo of USA Today, Crabtree tore his Achilles during a workout Tuesday, and will need surgery to repair the injury.
Dans la troisième lettre dinformation depuis son inauguration en 2010, la Hadopi (Haute Autorité pour la Diffusion des Oeuvres et de la Protection des droits sur Internet)... | Geomatic
Ehrlich, H. , Deutzmann, R. , Capellini, E. , Koon, H. , Solazzo, C. , Yang, Y. , Ashford, D. , Thomas-Oates, J. , Lubeck, M. , Baessmann, C. , Langrock, T. , Hoffmann, R. , Wörheide, G. , Reitner, J. , Simon, P. , Ereskovsky, A. V. , Mertig, M. , Vyalikh, D. V. , Molodtsov, S. L. , Worch, H. , Brunner, E. , Smetacek, V. and Collins, M. (2010 ...
Ehrlich, H. , Deutzmann, R. , Capellini, E. , Koon, H. , Solazzo, C. , Yang, Y. , Ashford, D. , Thomas-Oates, J. , Lubeck, M. , Baessmann, C. , Langrock, T. , Hoffmann, R. , Wörheide, G. , Reitner, J. , Simon, P. , Ereskovsky, A. V. , Mertig, M. , Vyalikh, D. V. , Molodtsov, S. L. , Worch, H. , Brunner, E. , Smetacek, V. and Collins, M. (2010 ...
Sanchez, Pedro A.; Palm, Cheryl A.; Sachs, Jeffrey D.; Denning, Glenn L.; Flor, David Rafael; Harawa, Rebbie; Jama, Bashir; Kiflemariam, Tsegazeab; Konecky, Bronwen; Kozar, Raffaela; Lelerai, Eliud; Malik, Alia; Mutuo, Patrick; Niang, Amadou; Okoth, Herine; Place, Frank; Sachs, Sonia Ehrlich; Said, Amir; Siriri, David; Teklehaimanot, Awash; Wang, Karen; Wangila, Justine; Zamba, ...
Spe-cial from the Dun-dalk Ea-gle. - Repub-li-can pres-i-den-tial nom-i-nee Don-ald Trump vis-ited the Boule-vard Diner as a part of his visit to Bal-ti-more on Mon-day af-ter-noon.. Around 100 sup-port-ers, as well as lo-cal politi-cians, came out to the diner to show sup-port for the nom-i-nee, who had spo-ken at the Na-tional Guard As-so-ci-a-tion of the United States 138th Gen-eral Con-fer-ence & Ex-hi-bi-tion in the Bal-ti-more Con-ven-tion Cen-ter ear-lier in the day.. Trump had lunch with sev-eral po-lit-i-cal fig-ures, in-clud-ing State Sen. Johnny Ray Salling (R-Bal-ti-more County), for-mer Mary-land Gov. Robert Ehrlich and for-mer New York City Mayor Rudy Gi-u-liani.. "It was just great see-ing him," Salling said. "I had lunch with Don-ald Trump. We talked about the is-sues in our state and some of the is-sues in our coun-try. We. DUN-DALK. had a good time.". Bal-ti-more County Coun-cil-man Todd Cran-dell, who rep-re-sents Es-sex and Dun-dalk, said "it means a lot to th-ese ...
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Ectopic expression of miR-31 suppresses migration and invasion of ESCC and EAC cell lines. TE8 and FLO1 cells were transfected with pre-miR-31 containing vector
TY - JOUR. T1 - Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells. AU - Fry, D. W.. AU - Yalowich, J. C.. AU - Goldman, I. David. PY - 1982. Y1 - 1982. N2 - The intracellular accumulation of poly-γ-glutamyl derivatives of methotrexate was evaluated in the presence of vincristine or probenecid (agents which raise the intracellular level of free methotrexate) in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by these agents and that, in the presence of L-glutamine, polyglutamate derivatives are increased by a higher percentage than is methotrexate. From 1 to 50 μM vincristine increased the levels of polyglutamate derivatives from 25 to over 300%, whereas methotrexate was raised from 25 to 80%. Similarly, 50 to 200 μM probenecid increased methotrexate polyglutamate derivatives from 31 to 88%, whereas methotrexate was raised from 0 ...
Looking for online definition of Ehrlich diazo reagent in the Medical Dictionary? Ehrlich diazo reagent explanation free. What is Ehrlich diazo reagent? Meaning of Ehrlich diazo reagent medical term. What does Ehrlich diazo reagent mean?
1. BannisterAJ, KouzaridesT (2011) Regulation of chromatin by histone modifications. Cell Res 21: 381-395.. 2. LeeJS, SmithE, ShilatifardA (2010) The language of histone crosstalk. Cell 142: 682-685.. 3. ArnesenT, Van DammeP, PolevodaB, HelsensK, EvjenthR, et al. (2009) Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A 106: 8157-8162.. 4. BrownJL, RobertsWK (1976) Evidence that approximately eighty per cent of the soluble proteins from Ehrlich ascites cells are Nalpha-acetylated. J Biol Chem 251: 1009-1014.. 5. StarheimKK, GevaertK, ArnesenT (2012) Protein N-terminal acetyltransferases: when the start matters. Trends Biochem Sci 37: 152-161.. 6. MullenJR, KaynePS, MoerschellRP, TsunasawaS, GribskovM, et al. (1989) Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J 8: 2067-2075.. 7. SongOK, WangX, WaterborgJH, SternglanzR (2003) An ...
Dr. Garth Ehrlich, buy cialis expert researcher on chronic bacterial pathogenesis from Drexel University discusses that some of the most important research he is doing right now is establishing a link between periodontal bacteria and infections of the joints - whether they be peri-prosthetic joint infections, generic cialis which means if you have an artificial joint it gets infected - or whether you have somebody with osteoarthritis and the potential causative or exacerbative effect of periodontal pathogens.. Peri-prosthetic joint infections - are the most common reason a joint prosthesis needs to be removed, a very traumatic procedure. 100% of revision arthroplasties (joint prosthesis replacement) result from bacterial pathogens, and in the vast majority of cases there are bacteria present that had come from the mouth.. Osteoarthritis - the vast majority of people who have osteoarthritis have periodontal pathogens in their joints. Dr. Ehrlichs research is looking at whether these periodontal ...
Ehrlichs crowning achievement was his discovery of Salvarsan, the "magic bullet" that marks the beginning of chemotherapy. Early in his career, Ehrlich had performed an intensive series of experiments on the differential staining of bacteria, which would take up aniline dyes while surrounding tissues remained unaffected. It was from the results of these experiments that Ehrlich conceived his idea of a magic bullet; i.e., a drug that could seek out and destroy invading micro-organisms without harming healthy tissue. Ehrlichs subsequent discovery of the syphilis-specific Salvarsan was rooted in two important events: In 1905 Schaudinn and Hoffmann discovered the spirochete of syphilis, and Thomas and Breinl discovered that atoxyl, an arsenic derivative, was capable of curing rodents infected with Trypanosoma equinum, a micro-organism that caused diseases similar to spirochetal infections in humans. Acting upon these discoveries, Ehrlich and his assistant Hata began synthesizing and testing ...
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George Dunea Chicago, Illinois, United States Fig. 1, Phenylamine To understand Paul Ehrlich, the man who developed the first effective cure for syphilis, we must dial back to 1826. In that year, a German scientist called Otto Unverdoren isolated from indigo a volatile organic substance ...
Müller TD, Greene BH, Bellodi L, Cavallini MC, Cellini E, Di Bella D, Ehrlich S, Erzegovesi S, Estivill X, Fernández-Aranda F, Fichter M, Fleischhaker C, Scherag S, Gratacòs M, Grallert H, Herpertz-Dahlmann B, Herzog W, Illig T, Lehmkuhl U, Nacmias B, Ribasés M, Ricca V, Schäfer H, Scherag A, Sorbi S, Wichmann HE, Hebebrand J, Hinney A. Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. Obes Facts. 2012;5(3):408-19 ...
Conservatives spin population mark Oct. 12 Its been more than three decades since Stanford biologist Paul Ehrlich wrote his book "The Population Bomb," but the doom he foretold therein, according to much of the media today, has yet to pass. Meanwhile, the UN has officially declared that today in Sarajevo, the six billionth human arrived here on Earth. In his ground-breaking 1968 book, Ehrlich warned of a number of dire consequences of global overpopulation: mass extinctions, poverty and famine, ecological degradation, and more. Yet if you read the WASHINGTON TIMES, the DETROIT NEWS, or listen to NATIONAL PUBLIC RADIO today, youll hear that Ehrlich was wrong, and that overpopulation is actually good for you. Thats partially because the right-wing think-tank the CATO Institute and other globalization cheerleaders engineered the spin. A CATO press release calls the 6-billion mark "something to celebrate" because "there are fewer women dying during pregnancy … fewer people dying of childhood ...
Attaching a resume wont be accepted rather than the completed application form. The resume given below should help you realize how this type of restart has to be drafted. The job is done inside in a traditional office setting. In case youve located a job which you would like to fill out an application for subsequently the below covering letter will assist you as a guide when sending in your CV. Offer compelling proof you could do the job. Additionally, its possible that you learn about finance careers and search for accounts payable jobs on Monster. Description The Ascentis Finance team is composed of driven professionals who came to Ascentis since they want to build processes that will have a lasting and measurable effect on the business.. You can start with composing any previous balances that needs to be taken forward in the current statement and when there arent any prior accounts then you have the ability to write zero over there. The accounts payable procedure is often a fantastic ...
Supplement to Molecular Analysis of Pathogens in Otitis Media by PCR for Construction, Hybridization and Analysis of NTHi Distributed Genome Chips to statisitically identify OME-related virulence ...
In this project we propose to determine the role of candidate G protein-coupled receptors (GPCRs) in enforcing deletion of developing auto-reactive T cells in t...
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BTW - Timbridgee makes me think of Zaplet, an avant la lettre Web 2.0 company that probably died in 2001 or 2002. They had a whole series of Office features, all packaged in email- & web-enabled "zaplets" - does anybody recall that, or does anybody know what happened to their technology ...
Lango Allen, H; Estrada, K; Lettre, G; Berndt, SI; Weedon, MN; Rivadeneira, F; Willer, CJ; Jackson, AU; Vedantam, S; Raychaudhuri, S; +283 more... (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467 (7317). pp. 832-8 [Peer Reviewed Journal]. ...
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... is a condition in which fluid collects in spaces within your abdomen. They can be painful and keep you from moving around comfortably. Ascites can set the stage for an infection in your abdomen. Fluid may also move into your chest and surround your lungs. This makes it hard to breathe.
Ascites is a condition in which fluid collects in spaces within your abdomen. They can be painful and keep you from moving around comfortably. Ascites can set the stage for an infection in your abdomen. Fluid may also move into your chest and surround your lungs. This makes it hard to breathe.
Ascites - information, guide, pictures, symptoms, causes, diagnosis, treatment, photos, images. Ascites is a symptom of a disease rather than a disease by
In the present work, we studied the molecular mechanisms by which sodium butyrate sensitizes cancer cells towards cisplatin. HeLa cells were treated with 5 mM butyrate, with 8 μM cis-diaminedichloroplatinum II (cisplatin), or with both. Cells treated with both agents showed approximately two-fold increase of the mortality rate in comparison with cells treated with cisplatin only. Accordingly, the life span of albino mice transfected with Ehrlich ascites tumor was prolonged almost two-fold by treatment with cisplatin and butyrate in comparison with cisplatin alone. This showed that the observed synergism of cisplatin and butyrate was not limited to specific cell lines or in vitro protocols, but was also expressed in vivo during the process of tumor development. DNA labeling and fluorescence activated cell sorting experiments showed that cisplatin treatment inhibited DNA synthesis and arrested HeLa cells at the G1/S transition and early S phase of the cell cycle. Western blotting and chromatin ...
Vimentin, desmin, glial fibrillary acidic protein, neurofilament triplet proteins, and a mixture of cytokeratins were digested with Ca2+-activated neutral thiol proteinase isolated from Ehrlich ascites tumor (EAT) cells and porcine kidney. All intermediate filament proteins were degraded by the proteinase, although with different rates and Ca2+ optima. These results are in part at variance with our previous statement that the Ca2+-activated proteinase from EAT cells is specific for vimentin and desmin.. ...
Republican Robert L. Ehrlich Jr. and Democrat Kathleen Kennedy Townsend meet at a Gubernatorial Candidates Forum in Rockville. Later yesterday, she spoke in College Park.
Purpose: Tamoxifen (TAM) is a non-steroidal antiestrogen drug, used in the prevention and treatment of all stages of hormone-responsive breast cancer. Simvastatin (SIM) is a lipid-lowering agent and has been shown to inhibit cancer cell growth. The study aimed to investigate the effect of the combination of TAM and SIM in the treatment of estrogen receptor positive (ER+) breast cancer cell line, MCF-7, and in mice-bearing Ehrlich solid tumors.. Methods: MCF-7 cells were treated with different concentrations of TAM or/and SIM for 72 hours and the effects of the combination treatment on cytotoxicity, oxidative stress markers, apoptosis, angiogenesis, and metastasis were investigated using different techniques. In addition, tumor volume, oxidative markers, and inflammatory markers of the combined therapy were explored in mice bearing solid EAC tumors.. Results: The results showed that treatment of MCF-7 cells with the combination of 10 µM TAM, and 2 µM SIM significantly inhibited the increase in ...
As Goldman asserts, crystals are powerful, transformational tools, capable of even turning sound into light. While we may consider crystals to be both inert and lifeless, the reality is they constitute and comprise the very essence of our physical and even energetic composition. Our bodies, like crystals, are composed of silicone and water, and that is why we can so intensely feel the vibration of a crystal bowl resonating within us. If we believe that crystals are as much a part of the web of connection as we are, then we can readily recognize that crystals have the ability to act as intermediaries, enabling us to communicate and connect with higher levels of consciousness and existence. Crystals have unique paths-and it is believed by energy workers and healers that they too, have their own karmic lessons to fulfill and experience, not unlike humans. If one truly espouses the belief that everything in the Universe is interconnected, then one must recognize that crystals are really just another ...
Soft Tissue Sarcoma- what it looked like and how it changes This is how we started this journey and I would like people to see what this Soft Tissue Sarcoma looks like and how it changes this is how Purrkins became a tripawd. One day Purrkins came and laid his paw out, he put it on my hand! It was if he said hey Mom
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Organize your "routines" so that you have the most important stuff first. When I wrote for newspapers, well before digital publishing allowed very clear calculations of how much space you had, articles would often have to be longer or shorter. So the trick was to break the story down. Put all the important stuff up front. Anything that was interesting, but tangential or dispensible, you put in the last paragraphs. That way, if the story had to be cut due to space limitations, the main thrust of the story was intact and undamaged ...
A decisions been made. Thats the latest word from former Maryland governor Robert L. Ehrlich Jr. (R) on whether he is running again, as reported Friday night by WJZ, the CBS affiliate in Baltimore. The report is the most recent...
The New Abuja City Gate provides a dynamic entryway to Nigerias new capital city, serving multiple symbolic and practical functions. The iconic design of the Gates tower and pedestrian bridge creates an international landmark that points the way
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http://www.cyberpresse.ca/article/20080921/CPSOLEIL/80920112/5785/CPSOLEIL02 Le Soleil, Erick Labbé Ian Bussières Le Soleil, Québec Dans une lettre lue lors de la manifestation soulignant le premier anniversaire de la mort de Claudio Castagnetta, la famille du ressortissant italien a écorché le ministre de la Justice et de la Sécurité publique du Québec, Jacques Dupuis. «Le ministre Dupuis contrôle à la […]. ...
Ascites Pipeline Review, H1 2012, provides an overview of the Ascites therapeutic pipeline. This report provides information on the therapeutic development for Ascites, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Ascites. Ascites - Pipeline Review, H1 2012 is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team ...
Anti-infective Agents Drug Therapy Across the Lifespan Development of Anti-infective Therapy 1920s Paul Ehrlich worked on developing a synthetic chemical effective against infection-causing cells only Scientists discovered penicillin in a mold sample 1935 The sulfonamides were introduced Mechanisms of Action Interfere with biosynthesis of the bacterial cell wall Prevent the cells of the invading organism […]. Read more ...
Mast cells (MCs) were first described by Paul Ehrlich 1in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites....
With stroke of the pen inside Springfields City Hall Monday, Gov. Deval Patrick established a requirement that utility companies fix and closely monitor what state Rep. Lori Ehrlich, D-Marblehead, and others have long urged is an epidemic of leaky gas pipes, which pose a statewide public-safety hazard.Under the law, Grade 1 leaks, those determined to pose an immediate danger, will now be fixed without delay. Grade 2 are to be repaired within the next 12 months and Grade 3 pipes will
L. Ehrlich1, A. Höller1, L. Dröge1, W. Henrich1, F. Herse2, M. Golic1,2, F.H. Perschel3, R. Dechend2, B. Huppertz4, S. Verlohren1 ...
Ascites refers to the accumulation of fluid in the outer surface of the chickens abdominal (peritoneal) cavity. Mild or early stages of ascites may have no associated clinical signs; however as more fluid accumulates, it will cause chickens to appear bloated with an enlarged or swollen-looking abdomen. The fluid present (ascitic fluid) is usually serous in nature, which is a
Ascites in dogs is an abnormal build up of fluid in the abdomen. It is also called abdominal effusion. Heres what you should know.
L Ichou, N Carbonell, P E Rautou, L Laurans, S Bourcier, C Pichereau, J L Baudel, J B Nousbaum, C Renou, R Anty, J Tankovic, E Maury, B Guidet, L Landraud, H Ait-Oufella ...
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fulltext. Thiamine deficiency frequently occurs in patients with advanced cancer and therefore thiamine supplementation is used as nutritional support. Thiamine (vitamin B1) is metabolized to thiamine pyrophosphate, the cofactor of transketolase, which is involved in ribose synthesis, necessary for cell replication. Thus, it is important to determine whether the benefits of thiamine supplementation outweigh the risks of tumor proliferation. Using oxythiamine (an irreversible inhibitor of transketolase) and metabolic control analysis (MCA) methods, we measured an in vivo tumour growth control coefficient of 0.9 for the thiamine-transketolase complex in mice with Ehrlichs ascites tumour. Thus, transketolase enzyme and thiamine clearly determine cell proliferation in the Ehrlichs ascites tumour model. This high control coefficient allows us to predict that in advanced tumours, which are commonly thiamine deficient, supplementation of thiamine could significantly increase tumour growth through ...
A day after practicing with 49ers teammates, receiver Michael Crabtree skipped Tuesdays workout to rest his ailing feet.. Teammate Josh Morgan said Crabtree broke in a new pair of cleats Monday and came away with ill-effects from San Jose States field turf. Gesturing to female member of the press, Morgan explained the problem by saying "it was equal to her wearing a new pair of heels all day.". Before heading out Tuesday, Crabtree attended a morning classroom-style session with the rest of the camps participants.. But when he failed to show up on the practice field, it prompted a brief stir, especially in the wake of Crabtrees provocative comments Monday. Crabtree said then that he had no idea who the 49ers quarterback would be - despite repeated indications from Coach Jim Harbaugh that Alex Smith was his man.. Also on Monday, Crabtree downplayed Smiths role in organizing this camp, saying everyone chipped in to make it happen. That ran contrary to the prevailing sentiment that this ...
Summary: We studied the effect of the anticancer drug Ukrain on Lewis carcinoma in C57BL/6 mice. A marked progressive anticancer and anlimetastatic effect was observed. On day 33 of tumor development, the tumor growth inhibition and metastases inhibition index were 71.5% and 73.1%, respectively. The antimetastatic effect of the drug manifested as a decrease in both number and volume of lung metastases. This finding demon-strates that treatment with Ukrain in Lewis carcinoma-bearing mice not only prevents the formation of new metastases but also inhibits the growth of existing ones. In addition to possessing anticancer and antimetasta-tic effects, Ukrain has been demonstrated to affect parameters characterizing the state of the immune system. This effect manifested as an increase in the endocrine function of the thymus (a central organ of the immune system), an increase in serum interferon, adhesion of peritoneal macrophages and formation of antibodies against thymus-dependent antigen by spleen ...
Download This Cold Heaven: Seven Seasons in Greenland ebook by Gretel EhrlichType: pdf, ePub, zip, txt Publisher: VintageReleased: 2003Page Count: 377Language:
WIDE RECEIVER RANDY MOSS. (on wide receiver Michael Crabtree) "I think first and foremost Michael really has all the skills to be a complete wide receiver. If he did not have him so high. I just think that he just needed somebody really older that has really been through what he has been through to be able to get him down that path. Not look at me as a father figure or anything like that, just more as a friend and a teammate. Like I said yesterday, the first thing that I told him was that I am not here to replace him or do anything. I said (to him), Man, I want to play with you and let things happen together. He has had a hell of a year man. I think it is his best year in his professional career. Only thing I can hope is he continues to be the person he is. Keep making plays.". (on if he enjoys playing with Crabtree) "Yeah, because I think that I can speak for the whole offense, Crabtree has made some phenomenal plays this year. I think it starts out in practice really. I have not been here, I ...
Put down that triple-shot coffee and add our Cleanse + Awaken Shower Gel to your morning ritual. Created to make you feel invigorated from top-to-toe, weve taken the exfoliating powers found in apples to give our formula multi-tasking powers. Blended with apple AHAs to gently buff and our earthy-floral Crabtree scent, its an everyday go-to you can rely on for a little boost.
Cela doit faire près de trente ans depuis que, lorsque jétais un étudiant, jai fais connaissance avec la musique de Lili Boulanger en écoutant lenregistrement classique de Markevich, distribué par la compagnie Everest aux Etats-Unis (et maintenant disponible sur EMI). Jai été transporté par ce que jai entendu, et jai écris immédiatement à la sœur de Lili, Nadia, qui à lépoque était âgée de quatre-vingts ans, mais enseignait encore, et possédait la même admirable énergie qui lui avait attiré des élèves et admirateurs du monde entier pendant cinquante ans. Cette musique - ainsi que la lettre - changèrent ma vie. Après avoir passé lété de 1967 étudiant avec Nadia à Fontainebleau, je produisis ma première émission radiophonique musicale lannée suivante, et publia mon premier article - les deux portant sur le sujet de Lili (1968 était le cinquantième anniversaire de sa mort). Jai gardé un contact sporadique avec sa musique, et produit un enregistrement ...
Hoewel Nederland een neutrale positie innam in de eerste wereldoorlog, waren er wel artsen die zich als deskundige hulpverleners, als een soort artsen zonder grenzen avant la lettre, aanboden. Zo werkte de Nederlander Esser vanaf mei 1915 in dienst van de Oostenrijks-Hongaarse regering als burgerchirurg in Brno, NVPCWenen, Budapest en tenslotte Berlijn. Hij was een markante persoonlijkheid, onvermoeibaar, bruisend van de energie en met vele innovatieve idee n. Hij was weliswaar eigenzinnig maar voorzien van vele uiteenlopende kwaliteiten maar ook met weinig gevoel voor militaire verhoudingen. Toch bleek hij goed te kunnen samenwerken indien dit nodig was om een goede reconstructie te bereiken met andere specialisten als oogartsen, kaakchirurgen en algemeen chirurgen, vooral tijdens zijn latere verblijf in Berlijn van 1917-1925. Hij bleef echter een eenling behept met moeilijk bereikbare idealen die ook na de oorlog voltijds plastisch chirurg bleef, hoewel dit vak nog niet als zodanig was erkend. ...
Looking for online definition of Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog in the Medical Dictionary? Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog explanation free. What is Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog? Meaning of Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog medical term. What does Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog mean?
Ehrlichs reagent or Ehrlich reagent is a reagent that contains p-dimethylaminobenzaldehyde (DMAB) and thus can act as an indicator to presumptively identify indoles and urobilinogen. Several Ehrlich tests use the reagent in a medical test; some are drug tests and others contribute to diagnosis of various diseases or adverse drug reactions. A very common Ehrlich test is a simple spot test to identify possible psychoactive compounds such as tryptamines (e.g. DMT) and ergoloids (e.g. LSD). The reagent will also give a positive result for opium, despite the opiates not containing the indole functional group, because of the presence of tryptophan in natural opium. It is named after Nobel Prize winner Paul Ehrlich who used it to distinguish typhoid from simple diarrhoea. The reagent is prepared by dissolving 0.5-2.0 g of p-dimethylaminobenzaldehyde (DMAB) in 50 mL of 95% ethanol and 50 mL of concentrated hydrochloric acid and is best used when fresh. Other alcohols, such as 1-propanol, can also be ...
TY - JOUR. T1 - Metabolomics approach to reduce the Crabtree effect in continuous culture of Saccharomyces cerevisiae. AU - Imura, Makoto. AU - Iwakiri, Ryo. AU - Bamba, Takeshi. AU - Fukusaki, Eiichiro. PY - 2018/8/1. Y1 - 2018/8/1. N2 - The budding yeast Saccharomyces cerevisiae is an important microorganism for fermentation and the food industry. However, during production, S. cerevisiae commonly uses the ethanol fermentation pathway for glucose utilization if excess sugar is present, even in the presence of sufficient oxygen levels. This aerobic ethanol fermentation, referred to as the Crabtree effect, is one of the most significant reasons for low cell yield. To weaken the Crabtree effect in fed-batch and continuous culture, sugar flow should be limited. In addition, in continuous culture, the dilution rate must be reduced to avoid washing out cells. However, under such conditions, production speed might be sacrificed. It is difficult to solve this problem with the tradeoff between cell ...
Brain-derived neurotrophic factor (BDNF) promotes the biochemical and morphological differentiation of selective populations of neurons during development. In this study we examined the energy requirements associated with the effects of BDNF on neuronal differentiation. Because glucose is the preferred energy substrate in the brain, the effect of BDNF on glucose utilization was investigated in developing cortical neurons via biochemical and imaging studies. Results revealed that BDNF increases glucose utilization and the expression of the neuronal glucose transporter GLUT3. Stimulation of glucose utilization by BDNF was shown to result from the activation of Na+/K+-ATPase via an increase in Na+ influx that is mediated, at least in part, by the stimulation of Na+-dependent amino acid transport. The increased Na+-dependent amino acid uptake by BDNF is followed by an enhancement of overall protein synthesis associated with the differentiation of cortical neurons. Together, these data demonstrate the
... is a condition affecting babies whose mothers were exposed to the chemical aminopterin or methotraxate during pregnancy. Only about 50 cases have been reported. Babies exposed to aminopterin or methotraxate during development can be born with developmental delays such as inability to properly grow, abnormal arms or legs, and changes to the face or skull. Symptoms of fetal aminopterin syndrome depend on how early in pregnancy the woman is exposed to aminopterin or methotraxate and the dosage of the medication being used. There is no cure for fetal aminopterin syndrome, though symptoms can be managed. Aminopterin is no longer used, but methotraxate may still be used to treat some conditions such as cancer. Pregnant women should consult a physician before taking medications with either chemical ...

WikiGenes - Carcinoma, Ehrlich TumorWikiGenes - Carcinoma, Ehrlich Tumor

Chemical compound and disease context of Carcinoma, Ehrlich Tumor. *Incorporation of tritiated uridine into DNA of Ehrlich ... Gene context of Carcinoma, Ehrlich Tumor. *Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ... Ehrlich Tumor. *We report here that the addition of double-stranded RNA to an extract from Ehrlich ascites tumor cells which ... Ehrlich Tumor. *Duramycin has no effect on glycolysis catalyzed by cell-free extracts of Ehrlich ascites tumor cells in the ...
more infohttps://www.wikigenes.org/e/mesh/e/2526.html

Tumor growth activity of duloxetine in Ehrlich carcinoma in mice | BMC Research Notes | Full TextTumor growth activity of duloxetine in Ehrlich carcinoma in mice | BMC Research Notes | Full Text

The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. The effect of ... In conclusion, duloxetine has no direct effect on tumor growth and does not alter immunity. The drug increased the SOD that ... There was no difference between the groups regarding weight, abdominal circumference, ascites volume and number of tumor cells ... fights free radicals and led the migration of lymphocytes, suggesting that duloxetine could be used in tumor-bearing ...
more infohttps://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3655-4

Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their...Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their...

Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their ... Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their ... mice with developed Ehrlich ascites carcinoma and of the animals treated with antitumoral drug ruboxyl. The ratio between the ... SOD system in all the cell compartments studied in tumor-bearing animals. Ruboxyl appears to exhibit regulating effect on free ...
more infohttp://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1993-39-6-16-en

Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid TumorsCombination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors

Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Com... ... Carcinoma, Ehrlich Tumor. A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous ... A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a ... In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the ...
more infohttps://www.bioportfolio.com/resources/trial/125659/Combination-Chemotherapy-in-Treating-Patients-With-Metastatic-or-Unresectable-Solid-Tumors.html

CYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 AntibodyCYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 Antibody

Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Ehrlich Tumor Carcinoma. Among its ... associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association ... ehrlich tumor carcinoma. *ehrlichs tumor. lung squamous cell carcinoma. *epidermoid cell carcinoma of the lung ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP1A1&origene_myc_func=4

CYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 AntibodyCYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 Antibody

Diseases associated with CYP1A1 include Ehrlich Tumor Carcinoma and Lung Squamous Cell Carcinoma. Among its related pathways ... associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association ... ehrlich tumor carcinoma. *ehrlichs tumor. lung squamous cell carcinoma. *epidermoid cell carcinoma of the lung ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP1A1&hmdb=54&rf=/home/genecards/current/website/carddisp.pl

Dr. Jacob Shani, MD | Brooklyn, NY | Cardiovascular Disease Physician | VitalsDr. Jacob Shani, MD | Brooklyn, NY | Cardiovascular Disease Physician | Vitals

Ehrlich Tumor Carcinoma * Balloon Angioplasty (Coronary Angioplasty) * Hypertension * Heart Diseases * Myocardial Infarction ...
more infohttps://www.vitals.com/doctors/Dr_Jacob_Shani.html

Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor MalignanciesNiraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

Carcinoma, Ehrlich Tumor. A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous ... A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a ... In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the ... RATIONALE: Lenalidomide may stop the growth of solid tumors by blocking blood flow to the tumor. Drugs used in chemotherapy, ...
more infohttps://www.bioportfolio.com/resources/trial/184034/Niraparib-Plus-Carboplatin-in-Patients-With-Homologous-Recombination-Deficient-Advanced-Solid-Tumor.html

Alkylating Antineoplastic Agents
     Summary Report | CureHunterAlkylating Antineoplastic Agents Summary Report | CureHunter

The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug ... Ehrlich Tumor Carcinoma 01/01/1990 - "Effects of alkylating antineoplastics alone or in combination with 3-aminobenzamide on ... and NAD levels in human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo.". ... on the survival of FSaIIC tumor cells and of bone marrow CFU-GM from tumor-bearing C3H mice. ". ...
more infohttp://www.curehunter.com/public/keywordSummaryD018906-Alkylating-Antineoplastic-Agents.do

Find Research Outputs
             - Johns Hopkins UniversityFind Research Outputs - Johns Hopkins University

Studies on the Ehrlich ascites tumor. I. The enzymic and metabolic. KUN, E., Talalay, P. & WILLIAMS-ASHMAN, H. G., 1951, In : ... Intraepithelial carcinoma of the cervix and its clinical implications.. JONES, H. W., GALVIN, G. A. & TeLINDE, R. W., Jun 1951 ... Studies on the Walker tumor. I. Standardization of the growth of a. Talalay, P., TAKANO, G. M. & HUGGINS, C., 1952, In : Cancer ... A clinical analysis and follow-up study of 502 cases of carcinoma of the lung.. RIENHOFF, W. F., Jan 1950, In : Diseases of the ...
more infohttps://jhu.pure.elsevier.com/en/publications/?format=&page=6003

Behaviour of nucleolus during mitosis. A comparative ultrastructural study of various cancerous cell lines using the Ag-NOR...Behaviour of nucleolus during mitosis. A comparative ultrastructural study of various cancerous cell lines using the Ag-NOR...

en] Anaphase ; Animals ; Carcinoma, Ehrlich Tumor/pathology/ultrastructure ; Cell Line ; Cell Nucleolus/ultrastructure ; ...
more infohttps://orbi.uliege.be/handle/2268/29146

Frontiers | Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced Damage Are Mediated through the...Frontiers | Potential Protective Effects of Ursolic Acid against Gamma Irradiation-Induced Damage Are Mediated through the...

... inhibits tumor angiogenesis and induces apoptosis through mitochondrial-dependent pathway in Ehrlich ascites carcinoma tumor. ... Hsu, H. Y., Yang, J. J., and Lin, C. C. (1997). Effects of oleanolic acid and ursolic acid on inhibiting tumor growth and ... 2016). Ursolic acid-loaded chitosan nanoparticles induce potent anti-angiogenesis in tumor. Appl. Microbiol. Biotechnol. 100, ... UA was found not only to significantly inhibit tumor growth, but also to enhance the recovery of hematopoietic system post- ...
more infohttps://www.frontiersin.org/articles/10.3389/fphar.2017.00352/full

Biochemical properties of 5 sulfur substituted pyrimidine nucleosides and nucleotides<...Biochemical properties of 5 sulfur substituted pyrimidine nucleosides and nucleotides<...

TY - JOUR. T1 - Biochemical properties of 5 sulfur substituted pyrimidine nucleosides and nucleotides. AU - Bardos, T. J.. AU - Aradi, J.. AU - Ho, Y. K.. AU - Kalman, T. I.. PY - 1975. Y1 - 1975. UR - http://www.scopus.com/inward/record.url?scp=0016590249&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0016590249&partnerID=8YFLogxK. M3 - Article. C2 - 1059371. AN - SCOPUS:0016590249. VL - Vol.255. SP - 522. EP - 531. JO - Annals of the New York Academy of Sciences. JF - Annals of the New York Academy of Sciences. SN - 0077-8923. ER - ...
more infohttps://hungary.pure.elsevier.com/en/publications/biochemical-properties-of-5-sulfur-substituted-pyrimidine-nucleos

Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich...Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich...

... in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by ... in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by ... in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by ... in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by ...
more infohttps://einstein.pure.elsevier.com/en/publications/augmentation-of-the-intracellular-levels-of-polyglutamyl-derivati-2

Myrrh: Uses, Side Effects, Interactions, Dosage, and WarningMyrrh: Uses, Side Effects, Interactions, Dosage, and Warning

Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. Chemotherapy 1994:40: ...
more infohttps://www.webmd.com/vitamins/ai/ingredientmono-570/myrrh

Myrrh | Memorial Sloan Kettering Cancer CenterMyrrh | Memorial Sloan Kettering Cancer Center

Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. Chemotherapy 1994;40: ... C.molmol inhibits the growth of Ehrlich carcinoma cells in mice (4). The cytotoxic activities appear to be as effective as ... and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice. Cancer ... leading to inhibition of cellular proliferation and tumor growth (3). Another in vitro study found that myrrh gum had ...
more infohttps://www.mskcc.org/cancer-care/integrative-medicine/herbs/myrrh

Dr. Jack C Yalowich - Cancer Researcher at OSUCCC - JamesDr. Jack C Yalowich - Cancer Researcher at OSUCCC - James

DNA Damage ● Leukemia ● Carcinoma, Ehrlich Tumor ● Leukemia, Erythroblastic, Acute ● Leukemia L1210 ● Oxidative stress ● DNA ... Spine Tumors Treatment Squamous Cell Carcinoma Treatment Stomach (Gastric) Cancer Treatment Testicular Cancer Treatment Thyroid ... Acute Lymphoblastic Leukemia Treatment Acute Myeloid Leukemia Treatment Anal Cancer Treatment Basal Cell Carcinoma Treatment ... Pituitary Tumor Treatment Pleural Mesothelioma Treatment Prostate Cancer Treatment Rectal Cancer Treatment Sarcoma Treatment ...
more infohttps://cancer.osu.edu/research-and-education/find-a-researcher/search-researcher-directory/jack-c-yalowich

In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low...In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low...

B) Histological structure of treated tumors. B1-B3 - DPBS and LFAMF treated Ehrlich carcinoma has a solid structure and grows ... In vivo antitumor efficacy of AS-14-GMNPs in LFAMF was evaluated using solid Ehrlich carcinoma in which the tumor was ... Aptamer AS-14 delivers GMNPs to Ehrlich carcinoma tumor and links the particles with fibronectin molecules. Fns bind to the ... Aptamer AS-14 delivers the GMNPs to the Ehrlich carcinoma tumor and links the particles with fibronectin molecules. The low ...
more infohttps://www.thno.org/v07p3326.htm

Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytochemical and immunocytochemical study. -...Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytochemical and immunocytochemical study. -...

en] Animals ; Antibodies, Monoclonal/immunology ; Carcinoma, Ehrlich Tumor/metabolism/pathology/ultrastructure ; Cell Nucleolus ... en] We investigated the ultrastructural distribution of histones within Ehrlich tumor cell nucleoli by means of three ... Reference : Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytoch.... ... Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytochemical and immunocytochemical study. ...
more infohttps://orbi.uliege.be/handle/2268/29273

The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells...The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells...

T1 - The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor ... The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells ... The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells ... The role of glycolysis in the growth of tumor cells. I. Effects of oxamic acid on the metabolism of Ehrlich ascites tumor cells ...
more infohttps://researchexperts.utmb.edu/en/publications/the-role-of-glycolysis-in-the-growth-of-tumor-cells-i-effects-of-

Find Research Outputs
             - Experts@SyracuseFind Research Outputs - [email protected]

D-galactosamine tetra-O-acetate as chemotherapeutic agents with immunopotentiating effects in Ehrlich ascites tumor-bearing ... Cooper, P. S., Alguard, M. J., Ehrlich, R. D., Hughes, V. W., Kobayakawa, H., Ladish, J. S., Lubell, M. S., Sasao, N., Schüler ...
more infohttps://experts.syr.edu/en/publications/?format=&ordering=publicationYearThenTitle&descending=true&page=626

Development of colostrum MAF and its clinical applicationDevelopment of colostrum MAF and its clinical application

Ehrlich tumor carcinoma. Eradication of ascites tumor. In vivo. Koga, et al. 1999 [14]. ... Ehrlich tumor carcinoma. Enhancement of macrophage phagocytic activity and extension of the survival time of mice bearing ... Anti-tumor actibity. In vitro. Mohamad, et al. 2003 [15]. Purified GcMAF. Hepatocellular carcinoma. Anti-angiogenic activity ... Antitumor effect of vitamin D-binding protein-derived macrophage activating factor on Ehrlich ascites tumor-bearing mice. Proc ...
more infohttp://www.jneuropsychiatry.org/peer-review/development-of-colostrum-maf-and-its-clinical-application.html

https://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdqhttps://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdq

... mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. Not effective ... DMBA-induced rat mammary carcinoma and the following transplanted experimental tumors: sarcoma 180, plasma cell tumor LPC-1, ... Three transplantable rodent tumors (osteogenic sarcoma, Lewis lung carcinoma, and P388 leukemia). No antitumor activity at 20% ... Additional cell culture and animal studies involving more than a dozen other tumor models have been published.[1,4,6,8,9,14,15 ...
more infohttps://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdq
  • The drug increased the SOD that fights free radicals and led the migration of lymphocytes, suggesting that duloxetine could be used in tumor-bearing individuals. (biomedcentral.com)
  • RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. (bioportfolio.com)
  • To assess the efficacy of poly (ADP-ribose) polymerase (PARP) inhibition and the extent of DNA damage, patients will undergo serial tumor biopsies to measure DNA damage as quantified by levels of ᵞH2AX and RAD51 foci formation, as well as an assessment of PARP inhibitory activity. (bioportfolio.com)
  • RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (bioportfolio.com)
  • The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (curehunter.com)
  • Phase I trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic or unresectable solid tumors. (bioportfolio.com)
  • To determine the concentration of tumor cells presents in this suspension, cells are counted in the Neubauer chamber, and cells viability is determined by the trypan blue exclusion test. (biomedcentral.com)
  • Determine the maximum tolerated dose, recommended phase II dose, and associated toxic effects of the triple combination of continuous infusion fluorouracil, weekly gemcitabine, and oxaliplatin in patients with metastatic or unresectable solid tumors. (bioportfolio.com)
  • The primary endpoint will be identifying the recommended phase 2 dose (RP2D) and schedule of niraparib plus carboplatin, as well as establishing the anti-tumor efficacy of niraparib plus carboplatin as determined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria. (bioportfolio.com)