A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
Measurement of the intensity and quality of fluorescence.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Disruption of the non-covalent bonds and/or disulfide bonds responsible for maintaining the three-dimensional shape and activity of the native protein.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
The quantity of volume or surface area of CELLS.
Solutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
An organoplatinum compound that possesses antineoplastic activity.
A country in western Africa, east of MAURITANIA and south of ALGERIA. Its capital is Bamako. From 1904-1920 it was known as Upper Senegal-Niger; prior to 1958, as French Sudan; 1958-1960 as the Sudanese Republic and 1959-1960 it joined Senegal in the Mali Federation. It became an independent republic in 1960.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A body of stories, the origins of which may be unknown or forgotten, that serve to explain practices, beliefs, institutions or natural phenomena. Mythology includes legends and folk tales. It may refer to classical mythology or to a body of modern thought and modern life. (From Webster's 1st ed)
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.
An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Geographic area in which a professional person practices; includes primarily physicians and dentists.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.
A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.

The interaction of rhodium(II) carboxylates with enzymes. (1/1023)

The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irreversibly inhibited. Those enzymes without essential sulfhydryl groups were not affected. In each case, the rate of inactivation closely paralleled the observed toxicity and antitumor activity of rhodium(II) carboxylates; that is, rhodium(II) propionate greater than rhodium(II) acetate greater than rhodium(II) methoxyacetate. In addition, those enzymes that have been demonstrated to be most sensitive to established sulfhydryl inhibitors, such as glyceraldehyde-3-phosphate dehydrogenase, were also most sensitive to rhodium(II) carboxylate inactivation. Proton nuclear magnetic resonance measurements made during the titration of rhodium(II) acetate with cysteine showed that breakdown of the carboxylate cage occurred as a result of reaction with this sulfhydryl-containing amino acid.  (+info)

Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (2/1023)

The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties.  (+info)

Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells. (3/1023)

A monoclonal antibody (mAb; A10) raised against murine Ehrlich tumor cell surface carbohydrates was tested for reactivity with human normal and malignant tissues. A10 reacted strongly, with a high proportion of adenocarcinomas arising from colon and other tissues but not with breast carcinomas or other malignant tumors. Normal tissues were virtually A10 unreactive, except for the duct cells from breast and pancreas and some bronchial mucosae. Ultrastructural studies showed mAb A10 immunolabeling of both microvilli and mucin droplets in colon cancer cells but not in normal absorptive or globet cells. A10 reacted strongly with mucin-enriched fractions from colon cancer tissues and HT-29 xenografts but not from normal colon tissues. A10 epitope was carried on MUC1 derived from colon adenocarcinomas and probably on other mucin species, although not on MUC2 molecules. A10 epitope was resistant to exoglycosidases and periodate oxidation but sensitive to the Smith's degradation and beta-elimination, suggesting the involvement of O-linked carbohydrates in nonterminal reducing positions. A mucin-type glycosidic linkage was supported because of the lack of A10 reactivity with HT-29 cells grown with phenyl-N-acetyl-alpha-D-galactosaminide. Deglycosylation studies with trifluoromethanesulfonic acid pointed to the involvement of core mucin glycans in the A10 epitope. This epitope was resistant to protease, O- and N-glycanase treatments carried out on trifluoromethanesulfonic acid-deglycosylated mucins. Inhibition studies with core 1, core 2, core 3, and core 6 suggested the latter [GlcNAcbeta(1-6)GalNAc] as being involved in A10 epitope. Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer.  (+info)

Phospholipid metabolism in ehrlich ascites tumor cells. II. Turnover rate of ether phospholipids. (4/1023)

1. Radioactive precursors of phospholipids, i.e., 32Pi, [1-14C]glycerol, [2-3H]glycerol, and [1-14C]acetate, were individually injected into the peritoneal cavity of mice bearing Ehrlich ascites tumor cells and the rates of incorporation were estimated. 2. Although [2-3H]glycerol was not practically incorporated into ether phospholipids, the other three radioactive precursors were incorporated into diacyl, 1-O-alkenyl-2-acryl-, and 1-O-alkyl-2-acryl-GPE (GPC). 3. In the experiments on 32Pi or [1-14C]acetate incorporation, 1-O-alkyl compounds in the ethanolamine phosphoglyceride fraction showed high specific activities in comparison with 1-acyl compounds. In the case of [1-14C]glycerol incorporation, a high rate of incorporation into 1-O-alkyl compounds was not found. In the choline phosphoglyceride fraction, a high rate of incorporation of the above precursors into 1-O-alkyl compounds was not observed. 4. The specific activities of 1-O-alkenyl compounds were fairly low compared with those of 1-acyl- and 1-O-acyl- and 1-O-alkyl compounds throughout the incorporation experiments with [1-14C]glycerol and [1-14C]acetate, but in 32Pi incorporation, 1-O-alkenyl compounds showed higher specific activities than 1-acyl compounds in ethanolamine phosphoglyceride, suggesting an exchange reaction of the phosphorylethanolamine moiety. 5. From the above findings, it appears that alkyl ether phospholipids of ethanolamine from may have a significant role in ascites tumor cells, based on their rapid turnover.  (+info)

Isolation of ekatetrone, a new metabolite of producing variants of Streptomyces aureofaciens. (5/1023)

From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of Ehrlich's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis.  (+info)

New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies. (6/1023)

A new semisynthetic anti-tumour bis-indol compound, KAR-2 [3'-(beta-chloroethyl)-2',4'-dioxo-3,5'-spiro-oxazolidino-4-dea cetoxy-vinblastine] with lower toxicity than vinca alkaloids used in chemotherapy binds to calmodulin but, in contrast to vinblastine, does not exhibit anti-calmodulin activity. To investigate whether the modest chemical modification of bis-indol structure is responsible for the lack of anti-calmodulin potency and for the different pharmacological effects, new derivatives have been synthesized for comparative studies. The synthesis of the KAR derivatives are presented. The comparative studies showed that the spiro-oxazolidino ring and the substitution of a formyl group to a methyl one were responsible for the lack of anti-calmodulin activities. The new derivatives, similar to the mother compounds, inhibited the tubulin assembly in polymerization tests in vitro, however their inhibitory effect was highly dependent on the organization state of microtubules; bundled microtubules appeared to be resistant against the drugs. The maximal cytotoxic activities of KAR derivatives in in vivo mice hosting leukaemia P388 or Ehrlich ascites tumour cells appeared similar to that of vinblastine or vincristine, however significant prolongation of life span could be reached with KAR derivatives only after the administration of a single dose. These studies plus data obtained using a cultured human neuroblastoma cell line showed that KAR compounds displayed their cytotoxic activities at significantly higher concentrations than the mother compounds, although their antimicrotubular activities were similar in vitro. These data suggest that vinblastine/vincristine damage additional crucial cell functions, one of which could be related to calmodulin-mediated processes.  (+info)

Heterogeneity of native ribosomal 60-S subunits in Ehrlich ascites tumor cells cultured in vitro. (7/1023)

Native large ribosomal subunits in cultured Ehrlich ascites tumor cells analyzed by high-resolution CsCl isopycnic centrifugation consist of at least two classes of particles with densities of 1.57 g/cm3 (LI) and 1.59 g/cm3 (LII), respectively. A wash with 0.5 M KCl converts LI into particles with the density of LII particles. Incubation of derived large subunits (density 1.59 g/cm3) with 0.5 M KCl wash of reticulocyte ribosomes leads to the formation of particles with the density of LI particles. A protein with a molecular weight of 57000 present in the high-KCl wash of 60-S native subunits was virtually absent in the KCl wash of 40-S subunits or polyribosomes suggesting that specific protein factors may be present on some native 60-S subunits. Possible functions of these protein factors are discussed.  (+info)

Glyceraldehyde-3-phosphate dehydrogenase from Ehrlich ascites carcinoma cells its possible role in the high glycolysis of malignant cells. (8/1023)

Glyceraldehyde-3-phosphate dehydrogenase has been purified to apparent homogeneity from Ehrlich ascites carcinoma (EAC) cells. The enzyme is quite active over a pH range of 7.5-9.0 with an optimum pH of 8.4-8.7. The specific activity of the enzyme is much higher than that from other normal sources. In contrast to enzyme obtained from rabbit muscle, the EAC cell enzyme is not significantly inhibited by physiological concentrations of ATP at physiological pH. Kinetic studies using different substrates and inhibitors indicate that the properties of the EAC cell enzyme are significantly different from those of glyceraldehyde-3-phosphate dehydrogenase obtained from other normal sources. The striking dissimilarity of the malignant cell glyceraldehyde-3-phosphate dehydrogenase compared with this enzyme from other normal sources, particularly in respect to the interaction with ATP, may in part explain the high glycolysis of malignant cells.  (+info)

Concomitant immunity is a phenomenon in which a tumour-bearing host is resistant to the growth of an implanted secondary tumour. Metastases are considered to be secondary tumours that develop spontaneously during primary tumour growth, suggesting the involvement of concomitant immunity in controlling the rise of metastases. It has been demonstrated that B-1 cells, a subset of B-lymphocytes found predominantly in pleural and peritoneal cavities, not only increase the metastatic development of murine melanoma B16F10, but also are capable of differentiating into mononuclear phagocytes, modulating inflammatory responses in wound healing, in oral tolerance and in Paracoccidiose brasiliensis infections. Here, we studied B-1 cells participation in concomitant immunity during Ehrlich tumour progression. Our results show that B-1 cells obtained from BALB/c mice previously injected with Ehrlich tumour in the footpad were able to protect BALB/c and BALB/Xid mice against Ehrlich tumour challenge. in ...
in European Journal of Cell Biology (1988), 47(2), 346-57. In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU ... [more ▼]. In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU) monoclonal antibody have been applied. In both cases, the immunogold labeling has been performed on ultrathin sections of cells embedded either in Lowicryl K4M or in Epon, respectively. Identical results are observed with both immunocytochemical approaches. In the interphase nucleolus, besides the labeling of the perinucleolar chromatin shell and of its intranucleolar invaginations which penetrate into the nucleolar body and often terminate at the fibrillar centers, a few gold particles are also preferentially found towards the peripheral ...
BioAssay record AID 118144 submitted by ChEMBL: Effect of compound on Ehrlich ascites carcinoma growth in CF1 mice at a dose ((20 mg/kg)/day) ip survival at day 9 packed cell volume as a percent.
en] Here we describe a new, rapid method for isolating nucleoli from Ehrlich tumor cells that preserves their morphological integrity and high transcriptional activity. Until now, methods for isolation of nucleoli were generally assumed to empty one of their three main compartments, the fibrillar center, of its contents. This new method consists of sonicating cells in an isotonic medium containing MgSO(4), spermidine, and spermine, followed by separation of nucleoli through a Percoll density gradient. Using the nonisotopic approach of labelling with BrUTP, we have further investigated the dynamics of nascent ribosomal RNAs (rRNAs) within morphologically intact isolated nucleoli at the electron microscope level. We show that ribosomal transcripts are elongated in the cortex of the fibrillar center and then enter the surrounding dense fibrillar component ...
Ca2+ uptake into Ehrlich ascites tumor cells was studied at 0°C in the presence of mitochondrial inhibitors, conditions that minimized complications caused by sequestration of Ca2+ into organelles or by excretion. Under these conditions Ruthenium Red inhibited Ca2+ uptake, but other previously implicated ions, such as Pi or Mg2+, had no effect. Valinomycin either inhibited or slightly stimulated Ca2+ uptake depending on the presence of excess K+ on the outside or inside of the cell, respectively. Nigericin inhibited Ca2+ transport. Based on these data we propose an electrogenic uptake of Ca2+, possibly via a Ca2+/H+ antiport mechanism. The observation that glucose inhibited Ca2+ uptake suggested that in Ehrlich ascites tumor cells an energy-driven Ca2+ expulsion mechanism is operative, similar to that in erythrocytes. Plasma membrane preparations of ascites tumor cells were found to contain a Ca2+-dependent ATPase. These preparations, when incorporated into liposomes in an inside-out orientation,
1. The formation of adenosine 5-phosphate, guanosine 5-phosphate and inosine 5-phosphate from [8-(14)C]adenine, [8-(14)C]guanine and [8-(14)C]hypoxanthine respectively in the presence of 5-phosphoribosyl pyrophosphate and an extract from Ehrlich ascites-tumour cells was assayed by a method involving liquid-scintillation counting of the radioactive nucleotides on diethylaminoethylcellulose paper. The results obtained with guanine were confirmed by a spectrophotometric assay which was also used to assay the conversion of 6-mercaptopurine and 5-phosphoribosyl pyrophosphate into 6-thioinosine 5-phosphate in the presence of 6-mercaptopurine phosphoribosyltransferase from these cells. 2. At pH 7.8 and 25 degrees the Michaelis constants for adenine, guanine and hypoxanthine were 0.9 mum, 2.9 mum and 11.0 mum in the assay with radioactive purines; the Michaelis constant for guanine in the spectrophotometric assay was 2.6 mum. At pH 7.9 the Michaelis constant for 6-mercaptopurine was 10.9 mum. 3. 25 mum-6
en] The cellular effects of dihydroflavopereirine and sempervirine ( two alkaloids isolated from Loganiaceae) are analysed by cytological methods in experimental tumours cultivated in vitro ( B16 mouse melanoma cells, mouse Ehrlich tumour cells ELT). Under some experimental conditions, a certain degree of antimitotic activity is demonstrated and related to the molecular structure ...
A comparison of the cytidine 5′-diphosphate (CDP) and adenosine 5′-diphosphate (ADP) reductase activities from Ehrlich tumor cells was made to determine if the properties of the enzyme for these substrates were the same, except for the allosteric effector. It was observed that various purification steps did not result in an enzyme fraction that had a constant ratio of CDP:ADP reductase activities. The optimal Mg2+ ion concentration for CDP reduction was 3 to 4 mm, while the optimal Mg2+ ion concentration for ADP reduction was 0.1 mm. Concentrations of Mg2+ ions greater than 0.1 mm inhibited ADP reduction. CDP reduction was relatively insensitive to the presence of dimethylformamide or dimethyl sulfoxide in the reaction mixture, but ADP reduction was decreased in the presence of these two compounds. Periodate-oxidized adenosine 5′-monophosphate, on incubation with the enzyme, had a greater effect on CDP reduction but little or no effect on ADP reduction. The response of the CDP and ADP ...
Until now the fluorescence assay with ethidium bromide has only been used on pure DNA. This assay depends on the difference in fluorescence between single- and double-stranded DNA (dsDNA). Cross-links in DNA are measured by the return of fluorescence of dsDNA after heat denaturation at pH 12. Under these conditions denatured DNA gives very low fluorescence. In the present study this assay was applied to tumor cells. The mouse Ehrlich ascites tumor cell line (EAT) and a human small-cell carcinoma line (GLC4) were incubated for 4 hr at 37 degrees C, with the cross-linking agent cis-diamino-dichloro platinum (cDDP). The samples of whole cells were thereafter resuspended in potassium phosphate buffer with 10 mM EDTA, 4M NaCl, 0.1% Sarkosyl pH 7.2, for 16 hr at 37 degrees C. Measurements were performed with a spectrofluorometer with excitation wavelength 525 nm, emission wavelength 580 nm. There was a linear relationship for cDDP concentrations of 0-150 microM and the extent of DNA cross-links in EAT ...
INTRODUCTION: Fluoroacetate (FA) is a highly toxic metabolic poison found in eight species of plants - including Dichapetalum and Gastrolobium - growing in Australia, South and Central Africa and South America. The level of FA in some plants can reach up to 5 g kg-1 dry weight and can cause death of livestock and domestic animals. Moreover, FA can be found in fog and rain-drops in some industrial regions. The best known representative of FA is its sodium salt (SFA, compound 1080), which is used in several countries for controlling populations of some vertebrates. Although extremely toxic, FA has positive properties: it can prevent development of tolerance to morphine, and has radioprotective power due to its capacity to reduce body temperature and oxygen consumption. OBJECTIVES: To evaluate the antitumor properties of SFA in monotherapy regime and in combination with a known antitumor compound. MATERIALS AND METHODS: Mice bearing Ehrlich tumor carcinoma were treated daily with SFA, 1.25mg/kg ...
The popularity of fermented foods such as kefir, kuniss, and tofu has been greatly increasing over the past several decades, and the ability of probiotic bacteria to exert anticancer effects has recently become the focus of research. While we have recently demonstrated the ability of the novel kefir product PFT (Probiotics Fermentation Technology) to exert anticancer effects in vitro, here we demonstrate its ability to inhibit Ehrlich ascites carcinoma (EAC) in mice. Mice were inoculated intramuscularly with EAC cells to develop solid tumors. PFT was administered orally (2 g/kg/day) to mice 6 days/week, either 2 days before tumor cell inoculation or 9 days after inoculation to mice bearing solid tumors. Tumor growth, blood lymphocyte levels, cell cycle progression, apoptosis, apoptotic regulator expression, TNF-α expression, changes in mitochondrial membrane potential (MMP), PCNA, and CD4+ and CD8+ T cells in tumor cells were quantitatively evaluated by flow cytometry or RT-PCR. Further studies in
Lassen, U; Nielsen, A; Pape, L; and Simonsen, L, The membrane potential of ehrlich ascites tumor cells, microelectrode measurements and their critical evaluation. (1971). Subject Strain Bibliography 1971. 2022 ...
Simonsen, L O. and Cornelius, F, Inorganic phosphate in ehrlich ascites tumor cells and its distribution across the cell membrane. (1978). Subject Strain Bibliography 1978. 3326 ...
Treatment of the 1-day-old Ehrlich ascites tumor with combinations of selected doses of l-asparaginase and the l-glutamine antagonist, 6-diazo-5-oxo-l-norleucine, or of the l-glutamine acid antagonist, dl-methionine-dl-sulfoximine, produced significantly more growth inhibition without a marked increase in host toxicity than did treatment with l-asparaginase administered alone. In the 3-day-old tumor treated with the combination of l-asparaginase and 6-diazo-5-oxo-l-norleucine, there was a significant enhancement of growth inhibition as compared with the effect of either drug used alone. A less significant increase of growth inhibition was obtained with combination of l-asparaginase and l-glutamyl-γ-hydrazide as compared with the effect of this chemical administered alone.. Combinations of l-asparaginase and 6-diazo-5-oxo-l-norleucine produced increased antitumor effects in mouse melanoma B16 and to a lesser degree in the solid form of Ehrlich tumor and Walker carcinosarcoma 256 of the ...
TY - JOUR. T1 - N-Bromoacetyl-β-D-glucosamine tetra-O-acetate and N-bromoacetyl-β-D-galactosamine tetra-O-acetate as chemotherapeutic agents with immunopotentiating effects in Ehrlich ascites tumor-bearing mice. AU - Simon, P.. AU - Burlingham, W. J.. AU - Conklin, R.. AU - Fondy, Thomas P. PY - 1979. Y1 - 1979. N2 - N-Bromoacetyl-β-D-glucosamine tetra-O-acetate (NBrAcGlc-TA) and N-bromoacetyl-β-D-galactosamine tetra-O-acetate (NBrAcGal-TA) produced strong in vitro cytotoxicity against both Ehrlich and L1210 leukemia dividing cell lines at μM concentrations. A single administration i.p. at one-half the dose lethal to 10% of the animals of either agent cured 85% of Ehrlich ascites tumor-bearing C57BL/6J x DBA/2 (hereafter called B6D2F1) mice. Animals immunosuppressed by prior X-irradiation could not be cured by these agents. The corresponding chloro and fluoroderivatives and the non-O-acetylated N-haloacetylhexosamines were inactive in vitro and in vivo. No significant effect against L1210 ...
Glutathione metabolism was studied in cancer cells during the growth of an Ehrlich ascites tumour. GSH, but not GSSG, content decreases when cell proliferation and the rate of protein synthesis in the tumour decrease. This change correlates with a decrease in the rate of GSH synthesis and an increase in glutathione peroxidase and glutathione S-transferase activities. Glutathione efflux from tumour cells seems to co-ordinate with the rate of GSH synthesis. Cysteine, and not methionine, promotes GSH synthesis in tumour cells. However, changes in the rate of GSH synthesis are not due to limitations in the supply of blood cysteine or to changes in the intracellular amino acid pool of the cancer cells. Our data suggest that changes in protein metabolism accompanying tumour growth in vivo can modulate glutathione content in cancer cells. ...
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TY - JOUR. T1 - Evaluation of intraperitoneal vincristine in malignant peritoneal effusion. AU - Bairy, K. L.. AU - Sanath, S.. AU - Jagetia, G. C.. AU - Somayaji, S. N.. AU - Vidyasagar, M. S.. AU - Baliga, M. S.. PY - 2003/1/1. Y1 - 2003/1/1. N2 - The efficacy and safety of intraperitoneal administration of vincristine sulphate was determined in mice bearing Ehrlich ascitic carcinoma. The tumor bearing animals were administered with 0.5 mg/kg body weight (b.wt) of freshly prepared vincristine sulphate intraperitoneally on day 6 after tumor transplantation followed by drug administration once daily 5 days a week consecutively. The observations regarding the survival, alteration in the volume of peritoneal fluid, increase in life span and pathological changes in the liver, kidney, gastrointestinal tract and bone tissues were made. The vincristine sulphate treatment reduced the malignant cell population significantly and there were no significant changes in the histological picture of liver, ...
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We have developed a simple and rapid method for isolation of purified nuclear lamina from Ehrlich ascites tumor cells. The procedure employs chromatin structures prepared from whole cells at low ionic strength and is carried out under conditions that minimize the formation of artifactual... mehr ...
4,4-Diisothiocyano-2,2-stilbenedisulfonic acid (DIDS) is an anion exchange inhibitor, blocking reversibly, and later irreversibly, exchangers such as chloride-bicarbonate exchanger. Jessen, Flemming; Sjøholm, C; Hoffmann, EK (1986), Identification of the anion exchange protein of ehrlich cells: A kinetic analysis of the inhibitory effects of 4,4′-diisothiocyano-2,2′-stilbene-disulfonic acid (DIDS) and labeling of membrane proteins with3H-DIDS, Journal of Membrane Biology, 92 (3): 195, doi:10.1007/BF01869388, PMID 3783658 Lane, Michelle; Baltz, Jay M.; Bavister, Barry D. (1999), Bicarbonate/Chloride Exchange Regulates Intracellular pH of Embryos but Not Oocytes of the Hamster, Biology of Reproduction, 61 (2): 452-457, doi:10.1095/biolreprod61.2.452, PMID 10411526 ...
A novel protein target of mouse calcyclin (S100A6) was detected by a gel overlay method with 125I-labelled calcyclin. Interaction of calcyclin with its 30 kDa target protein (p30) present in Ehrlich ascites tumour (EAT) cells depended on the presence of Ca2+ ions. The binding of p30, evidenced by the reaction with 125I-labelled calcyclin, was found to be of higher affinity than the binding between mouse calcyclin and annexin II or glyceraldehyde-3-phosphate dehydrogenase. Examination of tissue extracts by the gel overlay method has shown that p30 is present not only in the EAT cells but also in mouse brain and spleen. This novel target protein of mouse calcyclin was purified to homogeneity from EAT cells by means of Phenyl-Sepharose chromatography, affinity chromatography and CM-cellulose chromatography. Purified p30 was digested with α-chymotrypsin and a partial amino acid sequence of one of the resulting peptides was established. A database search analysis revealed that the sequence is ...
Radiosenstitizing effects of combination of a minor groove DNA ligand, Hoechst-33342, with the glucose analogue and inhibitor of glycolysis, 2-deoxy-D-glucose (2-DG) have been investigated in Ehrlich ascites tumour (EAT) bearing mice following focal irradiation of the tumour with 60Co gamma-rays. Treatment-induced tumour growth delay and tumour free animal survival were evaluated as parameters of radiation response. Focal irradiation of the tumour with a single fraction of 10 Gy induced a moderate delay in tumour growth but did not lead to complete regression in any of the tumours. Intravenous administration of H-342 1 hr before irradiation enhanced radiation-induced growth delay in a dose dependent manner. Complete regression of the tumour was observed only at a dose of 10 mg/kg body wt, leading to a cure (tumour free survival for more than 100 days) rate of 55%. Administration of 2-DG (2 g/kg body wt; iv), immediately before irradiation significantly enhanced radiation-induced growth delay and ...
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Introduction: Achillea fragrantissima extract has been used in folk medicine as an anticancer. The present study describes the antitumor activities of the extract and the flavonoid compounds and attempts to explain the mechanisms underlying these activities. Methods: The whole plant of A. fragrantissima was collected and ground to produce a fine powder which subjected to the maceration process. Step gradient elution was used using silica gel vacuum liquid chromatography (VLC). The fractions were compared by thin layer chromatography (TLC) and concentrated. Final purification was performed using Sephadex LH-20 to give three compounds cirsiliol, chrysosplenol D and cirsimaritin from F4 and one compound, eupatilin-7-methyl ether from F6. In this study, Ehrlichs ascites carcinoma (EAC) model was used as the model of cancer. Results: Achillea fragrantissima extract and its isolated methoxylated flavonoids significantly reduced the weight of tumor discs compared to EAC-control group. In addition,
Tumor cells intensely utilize glutamine as the major source of respiratory fuel. Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. In the present study, antitumor properties of acivicin in combination with glutaminase enzyme is reported. Acivicin along with E. coli glutaminase synergistically reduced in vitro proliferation and matrigel invasion of human MCF-7 and OAW-42 cells. Effects of single and combined treatments with acivicin and glutaminase on angiogenic factors were also analyzed in these cell lines. Co-administration of the treatment agents inhibits the release of VEGF and MMP-9 by cells in culture supernatant significantly than single agent treatments. The result suggests that combination of acivicin with glutaminase may provide a better therapeutic option than either of them given separately for treating human breast and ovarian cancer. However, further studies are required to be conducted in vivo for its confirmation ...
There are many medicinal applications found in Sapodilla fruit, bark, leaves & seeds like inhibition of ehrlich ascites carcinoma, in vitro and in vivo antioxi...
Atıf İçin Kopyala Ulukaya E., AKGÜN DAR K. , ARMUTAK E. İ. , KAPUCU A. 15th Congress of the European-Cancer-Organization/34th Multidisciplinary Congress of the European-Society-for-Medical-Oncology, EJC SUPPLEMENTS, Berlin, Almanya, 20 - 24 Kasım 2009, cilt.7, no.2, ss.96 ...
The purpose of this study was to determine whether changes in long-chain free fatty acid concentration would alter the transport and utilization of another organic ligand that was bound to human plasma albumin. Ehrlich ascites cells were incubated in medium containing human albumin, and the uptake of 2-(4-hydroxyphenylazo)benzoic acid was measured relative to the free fatty acid concentration of the medium. As the molar ratio of free fatty acid to albumin was raised from 1 to 4, hydroxyphenylazobenzoic acid uptake by the cells increased. In contrast, cells loaded with large quantities of fatty acid took up no more hydroxyphenylazobenzoic acid from an albumin-free medium than did cells loaded with only small amounts of fatty acid. Equilibrium dialysis binding measurements indicated that the binding capacity of human albumin for hydroxyphenylazobenzoic acid decreased as the molar ratio of free fatty acid to albumin was raised. Therefore, it is likely that the free fatty acid-induced increase in ...
ehrlich et al Maximum Hand-Rail And Hand-Rung Coupling Forces In Children: The Effects Of Diameter: Handhold diameter affects childrens ability to hang on. Human Factors (revisions submitted). Human Factors . 2012. In Press. Ehrlich et al 1. Clinico-pathologic Findings Predictive Of Relapse In Children With Stage III Favorable Histology Wilms Tumor: The Importance Of Lymph Nodes J Clinical Oncology Ehrlich et al Pediatric applied trauma research network: a call to action. J Trauma. 2010 Nov;69(5):1304-1307 Special commentary published simultaneously in Journal of Pediatric Surgery and Journal of Trauma. Ehrlich et al Evaluation of diagnostic performance of CT for detection of tumor thrombus in children with Wilms tumor: A report from the Childrens Oncology Group. Pediatr Blood Cancer. 2011 Jun 14. US Estimates of Hospitalized Children With Severe Traumatic Brain Injury: Implications for Clinical Trials. Pediatrics. 2011 Dec;129(1):e24-30. ...
Paul Ehrlich, founder and first president of the Zero Population Growth organization, was born in Philadelphia, Pennsylvania. He received a B.A. in zoology from the University of Pennsylvania in 1953 and an M.A. and Ph.D. from the University of Kansas in 1955 and 1957, respectively. He became a member of the faculty at Stanford University in 1959 and was named Bing Professor of Population Studies in 1976. He is a recipient of a MacArthur Foundation fellowship, and in 1990 he was awarded Swedens Crafoord Prize, created by the Royal Swedish Academy of Sciences to honor researchers in those disciplines not covered by the Nobel Prize. An expert in population biology, ecology, evolution, and behavior, Ehrlich has published more than 600 articles and scientific papers. He is perhaps best known for his environmental classic The Population Bomb (1968). Paul Ehrlich and his wife Anne began working together shortly after their marriage in 1954. Anne Ehrlich received her B.S. in biology from the ...
Meet Doctor Dion R Ehrlich. Here are his vitals: Hes board certified, specializing in Ophthalmology with expertise in this area. Doctor Ehrlich is a highly experienced doctor, with 35 years of practice in the field Highly regarded by his patients they rate him 4 out of 4 stars. They point out the time he spends with them. He has won Patients Choice Award. Is affiliated with a highly rated hospital. Graduated from George Washington University. He completed his fellowship at The Ohio State University in 1978. His average waiting time is 11 minutes. He accepts new patients. He has a number of insurance plans accepted. Use Vitals.com to examine Doctor Dion R Ehrlich from Philadelphia, Pennsylvania. See patient comments make an appointment or even let us help you to prepare for your visit. Vitals .com where doctors are examined.. ...
TY - JOUR. T1 - Decreased macrophage‐mediated cytotoxicity in mammary‐tumor‐bearing mice is related to alteration of nitric‐oxide production and/or release. AU - Sotomayor, Eduardo M.. AU - Dinapoli, Michael R.. AU - Calderón, Cesar. AU - Colsky, Arthur. AU - Fu, Yang‐Xin ‐X. AU - Lopez, Diana M.. PY - 1995/3/3. Y1 - 1995/3/3. N2 - Peritoneal‐exudate macrophages (PEM) from mammarytumor‐bearing mice have impaired cytotoxic activity against syngeneic and allogeneic tumor targets. The ability of PEM from normal and tumor‐bearing mice to bind tumor targets was found to be similar in the presence or the absence of surrogate receptors, which enhanced the binding but not the killing of tumor targets by PEM from tumor‐bearing mice, suggesting that other mechanisms are involved in their impaired cytolytic activity. Soluble and membrane‐bound TNF‐α, as well as H2O2, were found in higher amounts in PEM from tumor bearers upon stimulation with LPS, as compared with PEM from normal ...
The challenge of virulent strains of salmonella.. Radiation induced detoxification of endotoxin (LPS) of Salmonella. Studied the macrophage activation by the detoxified LPS.. Prepared vaccine against ascites tumor cells by coupling the ascites cells(Sarcoma 180) to LPS and Con A through glutarladehyde. This vaccine offered 100% protection against the challenge of ascites tumor cells in mice.. Activation of macrophages by different microorganisms. Immobilisation of bacterial cells to hydrolyse proteins from trash fish.. Isolation and characterization of the marine bacteria for the production of omega three fatty acids and optimization of cultural conditions for production is being standardized. Bryonia plant extract was shown to have anticancer properties against MCS human mammary cancer cells in vitro, while there is no toxicity to normal cells. Established grape precooling and cold storage technology and developed packaging and palletization technology in India. Exported grapes in refer ...
Previous observations in cancer patients and tumor-bearing animals suggested that myeloid lineage cells were involved in tumor-induced immunosuppression. Expansion of immature myeloid cells or macrophage/monocytes with characteristics of immune suppressive cells has been described in patients with head and neck cancer (6), gastric cancer (7), in mice bearing most carcinomas: Lewis lung carcinoma (8), Ehrlich carcinoma (9, 22), mammary adenocarcinoma (23), chemically induced fibrosarcoma (24), and colon carcinoma (13, 14, 15). This expansion was associated with a decline in T cell responses; however, little is known regarding the mechanism by which immune-suppressive cells inhibit primary T cell activation.. In the present study, we investigated how Gr-1+ myeloid cells, isolated from MCA-26 tumor-bearing mice and enriched by fractionation, contribute to inhibition of CD3/CD28-induced T cell activation. Several findings can be drawn from our experiments. We demonstrated a quantitative increase in ...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
central methylene group of bilirubin, first described by Dr. Ehrlich in [3, 4]. Serum bilirubin levels are frequently as high as 10 to 15 mg/dL and may be as . with Ehrlichs dimethylaminobenzaldehyde reagent to produce a pink colour, pigments react, therefore the concentration is termed total bilirubin (Table ...
Health,...The Caryl Ehrlich Program Changes Lives with 10-Sessions for Permanent... ...NEW YORK March 10 /- Theres an alternative to dieting t... ...,Behavioral,Approach,to,Weight,Loss,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Bernardoni F, Geisler D, King JA, Javadi AH, Ritschel F, Murr J, Reiter AMF, Rössner V, Smolka MN, Kiebel S, Ehrlich S. Altered Medial Frontal Feedback Learning Signals in Anorexia Nervosa. Biol Psychiatry. 2018 Feb; 83(3):235-243. doi: 10.1016/j.biopsych.2017.07.024. Bernardoni F, King JA, Geisler D, Birkenstock J, Tam FI, Weidner K, Roessner V, White T, Ehrlich S. Nutritional Status Affects Cortical Folding: Lessons Learned From Anorexia Nervosa. Biol Psychiatry. 2018 May; 84(9):692-701. doi: 10.1016/j.biopsych.2018.05.008.. Blokland GAM, Del Re EC, Mesholam-Gately RI, Jovicich J, Trampush JW, Keshavan MS, DeLisi LE, Walters JTR, Turner JA, Malhotra AK, Lencz T, Shenton ME, Voineskos AN, Rujescu D, Giegling I, Kahn RS, Roffman JL, Holt DJ, Ehrlich S, Kikinis Z, Dazzan P, Murray RM, Di Forti M, Lee J, Sim K, Lam M, Wolthusen RPF, de Zwarte SMC, Walton E, Cosgrove D, Kelly S, Maleki N, Osiecki L, [...]. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) ...
What kind of accounting is essential. Management accounting is made for internal clients like management and employees to help in the day to day functioning of the corporation. It may appear to be a complicated endeavor to many and not having applicable types could be one reason behind it. If you prepared the trust bookkeeping all on your own or together with the support of a lawyer, possess the trust accounting form assessed by means of a CPA before sending it to the beneficiaries. Accounting is a broad term that is utilized to define the monitoring and evaluation of a particular function, in order to maintain certain set of criteria for a company or business. Should you hunt for bookkeeping on the internet you may think of endless publications, articles, terms, and definitions. Though a probate accounting in California doesnt demand the preparation of some particular types or using any specific format, there are numerous pieces of advice you must put on your account. The accountants have some ...
serigraph. Edition: 40/75. support: 15 3/4 x 14 9/16 inches (40 x 36.99 cm). Collection Albright-Knox Art Gallery, Buffalo, New York. Charles W. Goodyear Fund, 1963. P1963:1. ...
When you express interest in a specific study, the information from your profile will be sent to the doctor conducting that study. If youre eligible to participate, you may be contacted by a nurse or study coordinator. If you select a health category rather than a specific study, doctors who have active studies in that area may contact you to ask if you would like to participate. In both cases, you will be contacted by the preferred method (email or phone) that you specified in your profile. ...
Living on Earth November 02, 2007 If you ask Paul Ehrlich, a professor of population studies at Stanford University, hell tell you the new UN report on the state of the global environment is old news. Dr. Ehrlich talks with host Bruce Gellerman about overpopulation, famine, and climate change, and the urgent need for the human species to save itself from disasters of its own making. ...
The 49ers suffered a major blow during OTAs, as wide receiver Michael Crabtree suffered what could be a season-ending injury. According to Mike Garafolo of USA Today, Crabtree tore his Achilles during a workout Tuesday, and will need surgery to repair the injury.
Dans la troisième lettre dinformation depuis son inauguration en 2010, la Hadopi (Haute Autorité pour la Diffusion des Oeuvres et de la Protection des droits sur Internet)... | Geomatic
Ehrlich, H. , Deutzmann, R. , Capellini, E. , Koon, H. , Solazzo, C. , Yang, Y. , Ashford, D. , Thomas-Oates, J. , Lubeck, M. , Baessmann, C. , Langrock, T. , Hoffmann, R. , Wörheide, G. , Reitner, J. , Simon, P. , Ereskovsky, A. V. , Mertig, M. , Vyalikh, D. V. , Molodtsov, S. L. , Worch, H. , Brunner, E. , Smetacek, V. and Collins, M. (2010 ...
Ehrlich, H. , Deutzmann, R. , Capellini, E. , Koon, H. , Solazzo, C. , Yang, Y. , Ashford, D. , Thomas-Oates, J. , Lubeck, M. , Baessmann, C. , Langrock, T. , Hoffmann, R. , Wörheide, G. , Reitner, J. , Simon, P. , Ereskovsky, A. V. , Mertig, M. , Vyalikh, D. V. , Molodtsov, S. L. , Worch, H. , Brunner, E. , Smetacek, V. and Collins, M. (2010 ...
Sanchez, Pedro A.; Palm, Cheryl A.; Sachs, Jeffrey D.; Denning, Glenn L.; Flor, David Rafael; Harawa, Rebbie; Jama, Bashir; Kiflemariam, Tsegazeab; Konecky, Bronwen; Kozar, Raffaela; Lelerai, Eliud; Malik, Alia; Mutuo, Patrick; Niang, Amadou; Okoth, Herine; Place, Frank; Sachs, Sonia Ehrlich; Said, Amir; Siriri, David; Teklehaimanot, Awash; Wang, Karen; Wangila, Justine; Zamba, ...
Spe-cial from the Dun-dalk Ea-gle. - Repub-li-can pres-i-den-tial nom-i-nee Don-ald Trump vis-ited the Boule-vard Diner as a part of his visit to Bal-ti-more on Mon-day af-ter-noon.. Around 100 sup-port-ers, as well as lo-cal politi-cians, came out to the diner to show sup-port for the nom-i-nee, who had spo-ken at the Na-tional Guard As-so-ci-a-tion of the United States 138th Gen-eral Con-fer-ence & Ex-hi-bi-tion in the Bal-ti-more Con-ven-tion Cen-ter ear-lier in the day.. Trump had lunch with sev-eral po-lit-i-cal fig-ures, in-clud-ing State Sen. Johnny Ray Salling (R-Bal-ti-more County), for-mer Mary-land Gov. Robert Ehrlich and for-mer New York City Mayor Rudy Gi-u-liani.. It was just great see-ing him, Salling said. I had lunch with Don-ald Trump. We talked about the is-sues in our state and some of the is-sues in our coun-try. We. DUN-DALK. had a good time.. Bal-ti-more County Coun-cil-man Todd Cran-dell, who rep-re-sents Es-sex and Dun-dalk, said it means a lot to th-ese ...
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Ectopic expression of miR-31 suppresses migration and invasion of ESCC and EAC cell lines. TE8 and FLO1 cells were transfected with pre-miR-31 containing vector
"Sacharose density gradient separation of Ehrlich ascites carcinoma and L-5178Y tumor cells in different cell cycle phases". ... Interference of Bruneomycin with the Cell Cycle of Ehrlich's Ascites Carcinoma]. Biológia (in Slovak). 35 (12): 875-80. ... Horáková, K (1975). "Ribonucleases in mouse ascitic tumor cells during ageing in vivo and in vitro". Advances in experimental ... Horáková, K (1972). "Polynucleotidases in mouse ascitic tumour cells". Neoplasma. 19 (5): 459-68. PMID 4345214. Fuska, JAN; ...
Mady, E. A. (2002). "Antitumor and biochemical effects of Echis coloratus crude venom on Ehrlich ascites carcinoma cells in ... "Role of dietary magnesium and/or manganese variables on ehrlich ascites tumor‐bearing mice". Nutrition and Cancer. 12 (3): 279- ... "Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ...
This property might be due to an acidic polypeptide found in its leaves that inhibited growth of Ehrlich ascites carcinoma ... In folk medicine, it is used to combat tumors. ...
"Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 ... "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". J. Biol. Chem. 278 ...
Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an ascites tumor in mice ... The tumor was cultured in vivo, which became known as the Ehrlich cell. After 1948 Ehrlich cultures spread around research ... "Osmotic properties of ehrlich ascites tumor cells during the cell cycle - Dupre - 2005 - Journal of Cellular Physiology - Wiley ... Dupre, Ann M.; Hempling, H. G. (December 1978). "Osmotic properties of ehrlich ascites tumor cells during the cell cycle". ...
"Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ... Apffel, C. A.; Arnason, B. G.; Peters, J. H. (1966). "Induction of tumour immunity with tumour cells treated with iodoacetate ... Several studies have shown iodoacetate has anti-tumor effects. In 2002 Dr. Fawzia Fahim showed that "a single IAA treatment of ... In 1966 Charles A. Apffel, Barry G. Arnason & John H. Peters showed anti-tumor activity for iodoacetate. Iodide is a naturally ...
His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming ... Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/ ... 1982 Rhoads Memorial Award 1982 PHS Meritorious Service Medal 1989 Paul Ehrlich Award 1989 PHS Distinguished Service Medal 1990 ... "Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma". ...
These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... Prevalence of hepatocellular carcinoma in individuals exposed to aflatoxin, increases with co-infection of hepatitus B virus. ... Yu J, Chang PK, Ehrlich KC, et al. (March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol ... Up to 44% of hepatocellular carcinomas in regions with high aflatoxin exposure bear a GC → TA transversion at codon 249 of p53 ...
Since the late 1970s, Rammensee has been focusing on immunology with the specific aim of using tumor immunology to fight ... 2013 Paul Ehrlich and Ludwig Darmstaedter Prize, 1996 Robert Koch Prize, 1993 Gottfried Wilhelm Leibniz Prize, 1992 Heinz Maier ... The immunopeptidomic landscape of ovarian carcinomas. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9942-E9951. doi: 10.1073/ ... Rammensee has contributed essentially to the research fields of MHC biology and tumor immunology and to the development of ...
... thereby promoting tumor cell proliferation. As a result, tumor vaccine strategies for Hsp70s have been highly successful in ... Changes of Hsp27 levels were observed in Ehrlich ascite cells, embryonic stem cells, normal B-cells, B-lymphoma cells, ... In particular, overexpression of HSP72 has been linked to the development of some cancers, such as hepatocellular carcinoma, ... Elevated Hsp70 levels in tumor cells may increase malignancy and resistance to therapy by complexing, and hence, stabilizing, ...
... but is significantly focally deleted across the entire dataset of 3131 tumors, suggesting that IRF8 is potentially a tumor ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (June 1995). "Functional domain analysis of interferon ... Molecular analysis indicated that the IRF8 gene promoter is hypermethylated in human colon carcinoma cells, suggesting that ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus ...
... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ... carcinoma, signet ring cell MeSH C04.557.470.200.025.415.410 --- krukenberg tumor MeSH C04.557.470.200.025.420 --- carcinoma, ... carcinoma, krebs 2 MeSH C04.557.470.200.260 --- carcinoma, large cell MeSH C04.557.470.200.280 --- carcinoma, lewis lung MeSH ... mixed tumor, malignant MeSH C04.557.435.530 --- mixed tumor, mesodermal MeSH C04.557.435.540 --- mixed tumor, mullerian MeSH ...
MSI-L tumors result from less than 30% of unstable MSI biomarkers. MSI-L tumors are classified as tumors of alternative ... MSI has been evident in the cause of sebaceous carcinomas. Sebaceous carcinomas are a subset of a larger pathology, Muir-Torre ... Ehrlich, Melanie, ed. (2000). DNA alterations in cancer: genetic and epigenetic changes. Natick, MA: Eaton Publ. p. 178. ISBN ... MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors ...
This paid off several years later in 1983 when zur Hausen identified HPV 16 DNA in cervical cancer tumors by Southern blot ... M Dürst; L Gissmann; H Ikenberg; H zur Hausen (1983-06-01). "A papillomavirus DNA from a cervical carcinoma and its prevalence ... Robert Koch Prize (1975) Charles S. Mott Prize (1986) Paul-Ehrlich-und-Ludwig-Darmstaedter-Preis (1994) Virchow Medal from the ... Coley Award for Distinguished Research in Basic and Tumor Immunology in 2006 (with Ian Frazer) AACR Award for Lifetime ...
"Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding ... S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma. GRCh38: Ensembl release 89: ENSG00000197956 ... "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid ... carcinoma". Thyroid. 20 (10): 1067-76. doi:10.1089/thy.2009.0400. PMID 20629554. Schäfer BW, Heizmann CW (1996). "The S100 ...
... the two decided to look at fine structures within the cells of the Ehrlich ascites carcinoma, a commonly used model for cancer ... "The Coming of Age of Tumor Virology." Cancer Research 37 (1977): 1255-1263 "Hemoglobin Synthesis in Murine Virus-induced ...
Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is ... Gemel J, Gorry M, Ehrlich GD, MacArthur CA (1996). "Structure and sequence of human FGF8". Genomics. 35 (1): 253-7. doi:10.1006 ... isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma". ... This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. ...
It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants ... Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni- ... in breast carcinomas". Int. J. Cancer. 107 (1): 155-8. doi:10.1002/ijc.11343. PMID 12925972. Dick FA, Sailhamer E, Dyson NJ ( ... "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. ...
"Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas". Applied ... Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A (May ... Götte K, Usener D, Riedel F, Hörmann K, Schadendorf D, Eichmüller S (July 2002). "Tumor-associated antigens as possible targets ... "Entrez Gene: RAGE renal tumor antigen". Eichmüller S, Usener D, Jochim A, Schadendorf D (August 2002). "mRNA expression of ...
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non tumor interact with Smad3 and inhibit the ... doi: 10.1002/hep.24087 ARUMUGAM M, RAES J, …… , BRECHOT C, MERIEUX A, …… , WEISSENBACH J, EHRLICH SD, BORK P. Enterotypes of ... hepatocellular carcinoma, HCC), as well as the molecular mechanisms underpinning liver regeneration and cancer (especially the ... to treat hepatocellular carcinoma. Christian Bréchot is a member of several specialized French and international medical ...
Another tumor-lysing virus that specifically targets tumor cells with an activated Ras pathway is a type II herpes simplex ... Rotblat B, Ehrlich M, Haklai R, Kloog Y (2008). "The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the ... Parada LF, Tabin CJ, Shih C, Weinberg RA (June 1982). "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ... The tumour suppressor gene NF1 encodes a Ras-GAP - its mutation in neurofibromatosis will mean that Ras is less likely to be ...
It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... Experiment also shows that drugs that block inflammation simultaneously inhibit tumour formation and development. Virchow was ... and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic pathology there. One of Virchow's ... First described by Karl Thiersch in the 1860s.) But he made a crucial observation that certain cancers (carcinoma in modern ...
... (September 11, 1904 - July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses, ... Principal 1978 Paul Ehrlich-Ludwig Darmstaeder Prize in Frankfurt Griffuel Prize in Paris (1978). Elected to the National ... murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. ...
... monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'- ... "Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil". ... "Effect of 5-phosphoribosyl-a-pyrophosphate on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells made permeable ... phosphate decarboxylase enzyme complex from mouse Ehrlich ascites cells". The Journal of Biological Chemistry. 254 (4): 1143-50 ...
In ovarian cancer, p27 negative tumors progressed in 23 months compared to 85 months in p27 positive tumors and thus could be ... In hepatocellular carcinoma cells p27 co-localizes with actin fibers to act on GTPase Rac and induce cell migration. In breast ... Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI (November 2000). "Disruption of TGF-beta growth ... In most cancers reduced levels of nuclear p27 are correlated with increased tumor size, increased tumor grade, and a higher ...
Ehrlich, HP; Diez, T (2003). "Role for gap junctional intercellular communications in wound repair". Wound Repair Regen. 11 (6 ... Tumor suppressor genes (Cx43, Cx32 and Cx36). *Adhesive function independent of conductive gap junction channel (neural ... "Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells". Dev. ... May 1996). "Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy". J. ...
... pancreatic tumors, colorectal tumors, and ovarian tumors. FAM149A has two transcription variants, transcript variant 1 and ... Ehrlich M (December 2009). "DNaseI hypersensitivity at gene-poor, FSH dystrophy-linked 4q35.2". Nucleic Acids Res. 37 (22): ... "Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and ... From the information in the second table, common complications involving FAM149A expression include adrenal tumors, ...
"The growth-related protein P23 of the Ehrlich ascites tumor: translational control, cloning and primary structure". ... controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library ... Translationally-controlled tumor protein has a role in tumor reversion and development. Translationally Controlled Tumor ... "Translationally controlled tumor protein is a target of tumor reversion". Proceedings of the National Academy of Sciences of ...
... in particular in which stopped the growth of human squamous cell carcinoma and human salivary gland tumor cell lines.". 2006. ... Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem. Pharm. Bull. 41 ...
It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... he was the first to describe a type of tumour called chordoma that originated from the clivus (at the base of the skull).[37][ ... and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic pathology there. One of Virchow's ... First described by Karl Thiersch in the 1860s.)[42] But he made a crucial observation that certain cancers (carcinoma in modern ...
Blood vessels in tumors are very different from those seen in normal tissues. As a tumor grows, tumor cells furthest away from ... The term was coined in the early 1900s by Paul Ehrlich as meaning any use of chemicals to treat any disease (chemo- + -therapy ... Tumor lysis syndrome[edit]. In particularly large tumors and cancers with high white cell counts, such as lymphomas, teratomas ... The newly formed tumor vasculature is poorly formed and does not deliver an adequate blood supply to all areas of the tumor. ...
Paul Ehrlich. ஜெர்மனி. 1909. Emil Theodor Kocher. சுவிட்சர்லாந்து. "for his work on the physiology, pathology and surgery of ... "for his discovery of the Spiroptera carcinoma"[20]. 1927. Julius Wagner-Jauregg. ஆஸ்திரியா. "for his discovery of the ... "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell"[66]. ...
Paul Ehrlich Germany 1909 Emil Theodor Kocher Switzerland "for his work on the physiology, pathology and surgery of the thyroid ... "for his discovery of the Spiroptera carcinoma" [27]. 1927 Julius Wagner-Jauregg Austria "for his discovery of the therapeutic ... "for his discovery of tumour-inducing viruses" [64]. Charles Brenton Huggins United States "for his discoveries concerning ... "for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell" [74]. ...
Ehrlich, HP; Diez, T (2003). "Role for gap junctional intercellular communications in wound repair". Wound Repair Regen. 11 (6 ... Tumor suppressor genes (Cx43, Cx32 and Cx36). *Adhesive function independent of conductive gap junction channel (neural ... "Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells". Dev. ... May 1996). "Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy". J. ...
Paul Ehrlich. Jerman. 1909. Emil Theodor Kocher. Swiss. untuk karyanya pada fisiologi, patologi dan operasi kelenjar tiroid[18] ... penemuan bahwa virus dapat memengaruhi tumor[65]. Charles Brenton Huggins. Amerika Serikat. penemuan perawatan kanker prostat ... penerangan Spiroptera carcinoma dan kanker yang dipengaruhi secara buatan pada hewan [29]. ...
for their discoveries concerning the interaction between tumour viruses and the genetic material of the cell ... գերմ.՝ Paul Ehrlich) Իլյա Իլիչ Մեչնիկով (ֆր.՝ Élie Metchnikoff) Իմունիտետի հայտնաբերման համար։. Բնօրինակ տեքստ (անգլ.) ... for his discovery of the Spiroptera carcinoma [27]. 1927 Յուլիուս Վագներ-Յաուրեգ. (գերմ.՝ Julius Wagner Ritter von Jauregg) ...
Another study, lead by Zhang B, created a L.lactis strain that maintains a plasmid containing a tumor metastasis-inhibiting ... Bolotin, A., Quinquis, B., Renault, P., Sorokin, A., Ehrlich, S. D., Kulakauskas, S., Lapidus, A.; et al. (2004). "Complete ... Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT ...
Another study, lead by Zhang B, created a L.lactis strain that maintains a plasmid containing a tumor metastasis-inhibiting ... CS1 maint: Multiple names: authors list (link) Bolotin, A., Quinquis, B., Renault, P., Sorokin, A., Ehrlich, S. D., Kulakauskas ... Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT ...
ME-CRCs isolated from MMTV-Neu transgenic mouse mammary tumors express high levels of HER2/neu, as well as tumor-initiating ... Kim, K.; Doi, A.; Wen, B.; Ng, K.; Zhao, R.; Cahan, P.; Kim, J.; Aryee, M. J.; Ji, H.; Ehrlich, L. I. R.; Yabuuchi, A.; ... teratoma-initiating embryonic-like carcinoma cells during differentiation. The survival of these teratoma-initiating cells is ... Importantly, the histopathology of these tumors was indistinguishable from that of the parental tumors that develop in the MMTV ...
Although c-Raf is very clearly capable of mutating into an oncogene in experimental settings, and even in a few human tumors, ... Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni- ... such as renal cell carcinoma and melanoma. Several other molecules followed up, such as Vemurafenib, Regorafenib, Dabrafenib, ... The latter became the focus of research in recent years, since a large portion of human tumors carry oncogenic 'driver' ...
Ehrlich, Brian D. Harfe, Steven A. Vokes. Dynamics of BMP signaling in limb bud mesenchyme and polydactyly (2014) Developmental ... and sarcoma carcinomas. More specifically, the Grem1 binding site (between residues 1 to 67) interacts with the binding protein ... "Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor ...
It can also serve as a marker of basal cell carcinoma, transitional cell carcinoma, salivary gland tumors, and thymoma. The ... Ehrlich P, Sybert VP, Spencer A, Stephens K (May 1995). "A common keratin 5 gene mutation in epidermolysis bullosa simplex-- ... Studies on lung cancer have also shown that squamous cell carcinomas give rise to tumors with elevated K5 levels, and that they ... This process has a large role in tumor progression and metastasis since it helps enable tumor cells to travel throughout the ...
Animals, Carcinoma, Ehrlich Tumor, Carcinoma, Small Cell, Cells, Cultured, DNA, Neoplasm, Ethidium, Fluorescence, Humans, ... The mouse Ehrlich ascites tumor cell line (EAT) and a human small-cell carcinoma line (GLC4) were incubated for 4 hr at 37 ... Detection of DNA cross-links in tumor cells with the ethidium bromide fluorescence assay. de Jong, S., Zijlstra, J. G., Timmer- ... In the present study this assay was applied to tumor cells. ...
Subject: fluoroacetate, Ehrlich tumor carcinoma, benzo[a]pyrene induced sarcoma Citation: Goncharov, N.V. et al. (2015) ... MATERIALS AND METHODS: Mice bearing Ehrlich tumor carcinoma were treated daily with SFA, 1.25mg/kg intraperitoneally. SHR mice ... RESULTS AND DISCUSSION: SFA significantly inhibited growth of Ehrlich tumor carcinoma. In experiments with autochthonous ... though both enhance the effect of CP increasing the number of mice with stabilized or decreased tumor volume. In contrast to ...
... either 2 days before tumor cell inoculation or 9 days after inoculation to mice bearing solid tumors. Tumor growth, blood ... PFT reduces tumor incidence and tumor growth in mice with EAC by inducing apoptosis in EAC cells via the mitochondrial- ... Our data shows that PFT exerts the following: 1) inhibition of tumor incidence and tumor growth; 2) inhibition of cellular ... here we demonstrate its ability to inhibit Ehrlich ascites carcinoma (EAC) in mice. Mice were inoculated intramuscularly with ...
Chemical compound and disease context of Carcinoma, Ehrlich Tumor. *Incorporation of tritiated uridine into DNA of Ehrlich ... Gene context of Carcinoma, Ehrlich Tumor. *Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ... Ehrlich Tumor. *We report here that the addition of double-stranded RNA to an extract from Ehrlich ascites tumor cells which ... Ehrlich Tumor. *Duramycin has no effect on glycolysis catalyzed by cell-free extracts of Ehrlich ascites tumor cells in the ...
Ehrlich Tumor Carcinoma. 5/2010. Comparison of glutathione reductase activity and the intracellular glutathione reducing ... Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells.. ... Mechanism of growth inhibitory effect of cape aloe extract in ehrlich ascites tumor cells.. ... reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor ...
The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. The effect of ... In conclusion, duloxetine has no direct effect on tumor growth and does not alter immunity. The drug increased the SOD that ... There was no difference between the groups regarding weight, abdominal circumference, ascites volume and number of tumor cells ... fights free radicals and led the migration of lymphocytes, suggesting that duloxetine could be used in tumor-bearing ...
The remaining mice were subjected to Ehrlich neoplasm cells. Group II: Tumor-bearing group. Group III: immune suppressant drug ... This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted ... Tumor sections in SEC post-treated with SFN revealed moderate numbers of apoptotic bodies with a tumor regression. G & H: Tumor ... Ehrlich malignant neoplastic disease is most sensitive to therapy as human tumors that thanks to their undifferentiation and ...
... was studied in Ehrlich ascites cells labelled in vivo for 24 h with myo-[2-(3)H]- or l-myo-[1-(3)H]inositol and exposed to ... Carcinoma, Ehrlich Tumor / pathology * Carcinoma, Ehrlich Tumor / physiopathology* * Cell Size * Culture Media ... Cell content of phosphatidylinositol (4,5)bisphosphate in Ehrlich mouse ascites tumour cells in response to cell volume ... In Ehrlich ascites cells, as shown previously, the opposing ion channels and transporters activated during RVD and RVI, ...
... were monitored in Ehrlich ascites tumor cells using Fura-2 or 2,7,-bis-(2-carboxyethyl)-5,6-carboxyfluorescein (BCECF), or ... Dynamics of Ca2+i and pHi in Ehrlich ascites tumor cells after Ca2+-mobilizing agonists or exposure to hypertonic solution ... Intracellular free calcium concentration ([Ca2+]i) and intracellular pH (pHi) were monitored in Ehrlich ascites tumor cells ... Carcinoma, Ehrlich Tumor / metabolism* * Cell Size * Fluoresceins * Fluorescent Dyes * Fura-2 * Hydrogen-Ion Concentration ...
Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their ... Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their ... mice with developed Ehrlich ascites carcinoma and of the animals treated with antitumoral drug ruboxyl. The ratio between the ... SOD system in all the cell compartments studied in tumor-bearing animals. Ruboxyl appears to exhibit regulating effect on free ...
... as an antitumor agent against Ehrlich ascites carcinoma (EAC). The first part of the study (tumor imaging) was to investigate ... Tumor volume and DNA, RNA, urea and malondialdehyde (MDA) levels and the liver enzymes activity were highly significantly ... The second part was the assessment of the antitumor activity of NBPQD by estimating the tumor volume and the contents of total ... as an antitumor agent against Ehrlich ascites carcinoma (EAC). The first part of the study (tumor imaging) was to investigate ...
Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Ehrlich Tumor Carcinoma. Among its ... associated with susceptibility to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia (in association ... ehrlich tumor carcinoma. *ehrlichs tumor. lung squamous cell carcinoma. *epidermoid cell carcinoma of the lung ...
This topic contains 45 study abstracts on Anti-Tumor agents such as Aloe Vera, Curcumin, and Maitake Mushroom ... Diseases : Ehrlich carcinoma. Pharmacological Actions : Anti-Tumor. [+] Anthocyanins from grape rinds and red rice exhibit ... Phyllanthus urinaria has anti-tumor and anti-angiogenic effects in mice bearing Lewis lung carcinoma. Jun 01, 2006. ... Diseases : Tumors. Pharmacological Actions : Anti-Tumor, Antiproliferative , Epidermal growth factor receptor (EGFR) inhibitor ...
Epithelial cells are highly proliferative and epithelial cancers, carcinomas, account for about 90% of all cancers. In this ... Epithelial cells are highly proliferative and epithelial cancers, carcinomas, account for about 90% of all cancers. In this ... Ehrlich ascites tumour cells; ECM, extracellular matrix; EGF, epidermal growth factor; ELA, Ehrlich Lettre ascites carcinoma; ... The Tumor Microenvironment (TME). Tumors are highly complex tissues in which the cancer cells themselves are often the minority ...
Carcinoma, Ehrlich Tumor. A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous ... A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a ... In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the ... RATIONALE: Lenalidomide may stop the growth of solid tumors by blocking blood flow to the tumor. Drugs used in chemotherapy, ...
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PUR... ... Carcinoma, Ehrlich Tumor. A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous ... Tumor-Infiltrating Podoplanin+ Fibroblasts Predict Worse Outcome in Solid Tumors.. Tumor-infiltrating fibroblasts are a ... RATIONALE: S-3304 may stop or slow the growth of solid tumors by stopping blood flow to the tumor. PURPOSE: Phase I trial to ...
Ehrlich Tumor Carcinoma * Balloon Angioplasty (Coronary Angioplasty) * Hypertension * Heart Diseases * Myocardial Infarction ...
Anticancer Activity Against Ehrlich Ascites Carcinoma in Mice. All the compounds were screened for their anticancer activity by ... The cells of Ehrlich ascites (EACs) tumor were obtained from National Cancer Institute (Cairo, Egypt). After harvesting and ... In addition, the anticancer activity of these complexes against Ehrlich ascites tumor cells (EACs) has been reported. ... The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). The higher ...
Mevalonic Acid Chicken Embryo Fibroblast Ascites Cell Ehrlich Ascites Carcinoma Cell German Cancer Research These keywords were ... D. E. Brennemann, L. McGee and A. A. Spector, Cholesterol metabolism in the Ehrlich ascites tumor, Cancer Res. 34:2605 (1974). ... Antagonistic effects of insulin and a negative growth regulator from ascites fluid on the growth of Ehrlich ascites carcinoma ... D. Barnes and G. H. Sato, Growth of human mammary tumor cell line in a serum-free medium, Nature (Lond.) 281:388 (1979). ...
Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. Chemotherapy 1994;40: ... C.molmol inhibits the growth of Ehrlich carcinoma cells in mice (4). The cytotoxic activities appear to be as effective as ... and antitumor properties of Commiphora molmol using normal and Ehrlich ascites carcinoma cell-bearing Swiss albino mice. Cancer ... leading to inhibition of cellular proliferation and tumor growth (3). Another in vitro study found that myrrh gum had ...
1985) Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals ... that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem 260:2719-2727. ...
Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an ascites tumor in mice ... The tumor was cultured in vivo, which became known as the Ehrlich cell. After 1948 Ehrlich cultures spread around research ... "Osmotic properties of ehrlich ascites tumor cells during the cell cycle - Dupre - 2005 - Journal of Cellular Physiology - Wiley ... Dupre, Ann M.; Hempling, H. G. (December 1978). "Osmotic properties of ehrlich ascites tumor cells during the cell cycle". ...
The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug ... Ehrlich Tumor Carcinoma 01/01/1990 - "Effects of alkylating antineoplastics alone or in combination with 3-aminobenzamide on ... and NAD levels in human lymphocytes in vitro and on Ehrlich ascites tumor cells in vivo.". ... on the survival of FSaIIC tumor cells and of bone marrow CFU-GM from tumor-bearing C3H mice. ". ...
Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. Chemotherapy 1994:40: ...
"Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers, ... Genome Medicine (2018) 10:42 Page 6 of 11 ab Tumor_Low Tumor_Low Tumor_High Tumor_High cd Tumor_Low Tumor_Low Tumor_High Tumor_ ... Functions of DNA methylation: islands, start sites, gene bodies 9. Ehrlich M. DNA methylation in cancer: too much, but also too ... Genome Medicine (2018) 10:42 Page 6 of 11 ab Tumor_Low Tumor_Low Tumor_High Tumor_High cd Tumor_Low Tumor_Low Tumor_High Tumor_ ...
The metabolic changes in tumor-associated macrophages during cancer grow in mice with Ehrlich ascites carcinoma. ... Connexin 43 expression in human brain glial tumors].. Kirichenko EY, Savchenko AF, Kozachenko DV, Akimenko MA, Filippova SY, ... Ultrastructural characteristics of gap junctions in human glial brain tumors].. Kirichenko EY, Savchenko AF, Kozachenko DV, ...
Ehrlich-Turk line explanation free. What is Ehrlich-Turk line? Meaning of Ehrlich-Turk line medical term. What does Ehrlich- ... Looking for online definition of Ehrlich-Turk line in the Medical Dictionary? ... Ehrlich tumor - solid or ascitic transplantable tumor derived from breast carcinoma in mice. ... Heinz-Ehrlich body - Synonym(s): Ehrlich inner body. Türk, Siegmund, 20th century Swiss ophthalmologist. Ehrlich-Türk line - ...
What is Ehrlich diazo reagent? Meaning of Ehrlich diazo reagent medical term. What does Ehrlich diazo reagent mean? ... Looking for online definition of Ehrlich diazo reagent in the Medical Dictionary? Ehrlich diazo reagent explanation free. ... Ehrlich tumor - solid or ascitic transplantable tumor derived from breast carcinoma in mice. ... Ehrlich unit. Ehrlich-Türk line - seldom-used term for the thin vertical deposition of material on the posterior surface of the ...
Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, D-60596 Frankfurt, Germany. ... Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, D-60596 Frankfurt, Germany. Electronic address ... Here we aimed to investigate the prognostic value of a soluble form of PD-L1 in hepatocellular carcinoma (HCC) patients. ... High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis.. ...
The extracts were then incubated with Ehrlich ascites carcinoma cells at 37 degrees C for 1 h. These pretreated cells were ... To the contrary, tumor cells which were pretreated with garlic extracts, produced ascites tumor in all mice that died 2 or 4 ... they acquired resistance against a challenge with Ehrlich ascites tumor cells. Administration of garlic extracts to mice for at ... Aboul-Enein AM: Inhibition of tumor growth with possible immunity by Egyptian garlic extracts. NAHRUNG 1986; 30(2):161-9 Garlic ...
... lung carcinoma), HeLa (cervical carcinoma), and THP-1 (acute monocytic leukemia) cells. Cell cycle analysis revealed that TF/ ... tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites ... carcinoma Madhulika Singh,1 Priyanka Bhatnagar,2 Sanjay Mishra,1 Pradeep Kumar,2 Yogeshwer Shukla,1 Kailash Chand Gupta1,2 ... Ehrlichs ascites carcinoma (EAC) cells were maintained as an ascitic tumor model in Swiss albino mice. In brief, tumors were ...
... stimulated with interleukin 2 and tested in a 4-hour 51chromium-release cytotoxicity assay against autologous cultured tumor ... Peripheral blood lymphocytes derived from patients with renal cell carcinoma were ... 270747 - Reduction of syngeneic tumor growth by an anti-i-j-alloantiserum.. 11370557 - Radiotherapeutic response of ehrlich ... Carcinoma, Renal Cell / blood, immunology*. Cytotoxicity Tests, Immunologic. Female. Humans. Interleukin-2 / immunology*. ...
... is a tumor whose past is filled with failed treatments and unpreventable patient death. Fortunately, science is progressing at ... cells in tumor-infiltrating lymphocytes of renal cell carcinoma associated with tumor progression. Eur Urol. 1992;22(4):323-328 ... Ehrlich P. Über den jetzigen Stand der Karzinomforschung. Ned Tijdschr Geneeskd. 1909;5:273-290.Google Scholar ... Tumor B7QQQH1 is associated with poor prognosis in renal cell carcinoma patients with longQQQterm followQQQup. Cancer Res. Apr ...
  • The mouse Ehrlich ascites tumor cell line (EAT) and a human small-cell carcinoma line (GLC4) were incubated for 4 hr at 37 degrees C, with the cross-linking agent cis-diamino-dichloro platinum (cDDP). (rug.nl)
  • Mice were inoculated intramuscularly with EAC cells to develop solid tumors. (biomedcentral.com)
  • PFT was administered orally (2 g/kg/day) to mice 6 days/week, either 2 days before tumor cell inoculation or 9 days after inoculation to mice bearing solid tumors. (biomedcentral.com)
  • In the present study this assay was applied to tumor cells. (rug.nl)
  • Tumor growth, blood lymphocyte levels, cell cycle progression, apoptosis, apoptotic regulator expression, TNF-α expression, changes in mitochondrial membrane potential (MMP), PCNA, and CD4+ and CD8+ T cells in tumor cells were quantitatively evaluated by flow cytometry or RT-PCR. (biomedcentral.com)
  • and 5) immunomodulation with an increase in the number of infiltrating CD4 + and CD8 + T cells and an enhancement of TNF-α expression within the tumor. (biomedcentral.com)
  • PFT reduces tumor incidence and tumor growth in mice with EAC by inducing apoptosis in EAC cells via the mitochondrial-dependent pathway, suppressing cancer cell proliferation, and stimulating the immune system. (biomedcentral.com)
  • MATERIALS AND METHODS: Mice bearing Ehrlich tumor carcinoma were treated daily with SFA, 1.25mg/kg intraperitoneally. (dmu.ac.uk)
  • In experiments with autochthonous induced by benzo[a]pyrene subcutaneous tumors, SFA exhibited enhancement of antitumor effect of cyclophosphamide (CP), significantly increasing the number of mice with stabilized or decreased tumor volume. (dmu.ac.uk)
  • Comparison of antitumor activity of SFA and metformin showed that neither compound has significant effect being administered in a monotherapy regimen, though both enhance the effect of CP increasing the number of mice with stabilized or decreased tumor volume. (dmu.ac.uk)
  • While we have recently demonstrated the ability of the novel kefir product PFT (Probiotics Fermentation Technology) to exert anticancer effects in vitro, here we demonstrate its ability to inhibit Ehrlich ascites carcinoma (EAC) in mice. (biomedcentral.com)
  • RESULTS AND DISCUSSION: SFA significantly inhibited growth of Ehrlich tumor carcinoma. (dmu.ac.uk)
  • Activity of the systems involved in generation and utilization of superoxide radicals was studied in microsomes, mitochondria and nuclei of liver tissue from intact mice, mice with developed Ehrlich ascites carcinoma and of the animals treated with antitumoral drug ruboxyl. (msk.ru)
  • Li, Yixue 2018-05-30 00:00:00 Background: Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. (deepdyve.com)
  • in Hepatocellular carcinoma (HCC) is the sixth most com- contrast, the main cause in developed countries, such as mon cancer and the third leading cause of cancer deaths the USA, is infection with hepatitis C virus (HCV) [2]. (deepdyve.com)
  • High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis. (nih.gov)
  • Here we aimed to investigate the prognostic value of a soluble form of PD-L1 in hepatocellular carcinoma (HCC) patients. (nih.gov)
  • Soluble PD-L1 and prognosis of patients with hepatocellular carcinoma. (nih.gov)
  • Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. (ebscohost.com)
  • An increasing trend of incidence in hepatocellular carcinoma (HCC) has been recorded in most developed countries. (cancerjournal.net)
  • IFN-œ2a) against the growth of Hep-G2 cells (human hepatocellular carcinoma), EAC-induced tumors (Ehrlich Ascites Carcinoma) in mice prove the functionality of the produced IFN-œ2a as an anticancer drug. (springer.com)
  • Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma. (springer.com)
  • The treatment with the LAT1 inhibitor decreased the sensitivity of the Ehrlich ascites carcinoma cells to complexes 1 and 2 in vitro-which suggests that the LAT1 could be related to the mechanism of action of amino acid/ruthenium(II) complexes, consequently decreasing the glucose uptake. (bireme.br)
  • Incubation of Ehrlich ascites tumor cells in vitro with [ 3 H] dihydrofolate results in its rapid conversion to [ 3 H] tetrahydrofolate and other radiolabeled compounds, so that dihydrofolate cannot be detected in the cell. (elsevier.com)
  • MANOJKUMAR P, RAVI TK, GOPALAKRISHNAN G. Synthesis of coumarin heterocyclic derivatives with antioxidant activity and in vitro cytotoxic activity against tumour cells. (srce.hr)
  • Le Blanc et al, "An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines", Pharmacol. (patentgenius.com)
  • Percivall Pott identifies a relationship between exposure to chimney soot and the incidence of squamous cell carcinoma of the scrotum among chimney sweeps. (cancer.gov)
  • A low-molecular-weight fraction (M.W. ∼700) that specifically impairs the induction of type II interferon in mice by purified protein derivative of tuberculin or OK-432 was isolated from the cell-free ascitic fluid of mice bearing Ehrlich ascites carcinoma. (aacrjournals.org)
  • To assess the efficacy of poly (ADP-ribose) polymerase (PARP) inhibition and the extent of DNA damage, patients will undergo serial tumor biopsies to measure DNA damage as quantified by levels of ᵞH2AX and RAD51 foci formation, as well as an assessment of PARP inhibitory activity. (bioportfolio.com)
  • Results of one study reveal that the Na, K and Ca levels in cancer cells were reduced by treatment of C. molmol, leading to inhibition of cellular proliferation and tumor growth (3) . (mskcc.org)
  • A cold target cell inhibition test was performed in 2 patients with unlabeled autologous tumor and K562 cells as cold inhibitors. (biomedsearch.com)
  • In 1 patient unlabeled K562 completely inhibited the tumor lysis but in 1 complete inhibition by autologous tumor and incomplete blockade by K562 were found. (biomedsearch.com)
  • Complexes 1 and 2 (2 and 6 mg kg ) showed tumor growth inhibition ranging from moderate to high. (bireme.br)
  • Secondly, 4-coordinate planar copper complexes will get attached to nitrogen base of DNA, thus blocking the base replication leading to the inhibition of tumour growth than 6-coordinate complexes of Fe(III) [ 13 ]. (ijpsonline.com)
  • In an Ehrlich ascites carcinoma model in BALB/c mice, fenugreek seed extract produced a 70% inhibition of tumor cell growth when compared to controls [8]. (b92.net)
  • Therefore, probenecid might support the effect of anti - cancer drugs via inhibition of efflux of these drugs from tumor cells. (nii.ac.jp)
  • Furthermore, the Gr-1 + /Mac-1 + immune suppressive cell population was recently shown to be involved in inhibition of CD8 + cell generation in the tumor host through apoptosis and a contact-dependent mechanism ( 15 ). (jimmunol.org)
  • Artemisia nilagirica (Clarke) shown significant tumor inhibition and decrease in viable cell count thereby increasing the lifespan of Ehrlich's ascites carcinoma (EAC) bearing mice and brought back hematological parameters to more or less normal level. (ispub.com)
  • 1'S)-Acetoxychavicol acetate and its enantiomer inhibit tumor cells proliferation via different mechanisms. (curehunter.com)
  • Because rapid tumor proliferation is associated with poor patient prognosis, here we characterized the transcriptional signature of rapidly proliferating colorectal cancer cells in an attempt to identify novel candidate therapeutic targets. (aacrjournals.org)
  • CTL activity and T lymphocyte proliferation in response to alloantigens can be significantly inhibited by Mac-1-positive cells derived from the spleen of mice bearing colon carcinoma ( 13 ). (jimmunol.org)
  • Treatment with BV or MEL markedly suppresses the proliferation of tumor in EAC mice. (greenmedinfo.com)
  • The Ehrlich ascites carcinoma model was used to evaluate the antitumor activity of HE-02 (6.25, 12.5 or 25 mg/kg, intraperitoneally, i.p.), as well as toxicity. (mdpi.com)
  • Purpose: To evaluate Plumeria alba leaves for antitumor activity against Ehrlich ascites carcinoma (EAC) and Dalton lymphoma ascites (DLA) bearing Swiss albino mice. (who.int)
  • Antitumor And Antioxidant Activity Of Artemisia Nilagirica (Clarke) Against Ehrlich's Ascites Carcinoma In Swiss Albino Mice. (ispub.com)
  • EAC cells were maintained by serial transplantation from tumor bearing swiss albino mice. (ispub.com)
  • The anti-tumor activity of the sea snake venom ( Hydrophis spiralis ) was evaluated against Ehrlich s Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. (scialert.net)
  • Wiemann B, Starnes CO. Coley's toxins, tumor necrosis factor and cancer research: a historical perspective. (springermedizin.de)
  • Frei E 3rd, Spriggs D. Tumor necrosis factor: still a promising agent. (springermedizin.de)
  • Next, we will review and critically discuss how dys-regulation of cell volume or given ion transporters can lead to loss of epithelial architecture, altered cell survival, tumor progression, and drug resistance. (frontiersin.org)
  • Genome Medicine (2018) 10:42 Page 2 of 11 are diagnosed at an early stage [3], while the 5-year that the circulating tumor DNA (ctDNA) methylation of survival rate decreases to approximately 10% for another ten CpGs could also discriminate HCC patients advanced HCC patients [4]. (deepdyve.com)
  • Therefore, these complexes could be used to reduce tumor growth and increase mean survival time with less toxicity than cisplatin. (bireme.br)
  • Therefore, the methylation status of immune synapse genes reflects tumor immunogenicity and correlates with survival. (jci.org)
  • Administration of the copper complex at different concentrations (10, 5 and 1 mg/kg b. wt) inhibited the solid tumour development in mice and increased the mean survival rate and the life span of Ascites tumour bearing mice in a concentration dependent manner. (ijpsonline.com)
  • 0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg -1 ) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). (scialert.net)
  • 0.001) increases of survival times 33±1.81 days for crude extract of the (50 mg kg -1 ) treated tumor bearing mice were confirmed with respect to the control group (20±0.12 days). (scialert.net)
  • Unfortunately, androgen-independent tumor recurrence is almost ubiquitous, for which only palliative treatment is available, and even the newest docetaxel-based regimes confer only a 2.4-month survival advantage ( 3 ). (aacrjournals.org)
  • Garlic also suppresses experimental tumor growth: garlic-fed mice bearing Ehrlich ascites tumors had significantly prolonged survival compared with control ( 8 ), and three groups have noted that both s.c. and oral fresh garlic and aged garlic extract (AGE) administration suppressed the growth of transitional cell carcinoma xenografts ( 9 - 11 ). (aacrjournals.org)
  • The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. (biomedcentral.com)
  • This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). (scirp.org)
  • In Ehrlich ascites cells, as shown previously, the opposing ion channels and transporters activated during RVD and RVI, respectively, are controlled with tight negative coordination by a common cell volume 'set-point' that is shifted in anisotonic media, but unchanged during cell swelling in isosmotic high K(+) medium. (nih.gov)
  • Administration of ruboxyl into healthy animals led to distinct increase in this ratio in mitochondria, while the drug normalized patterns of the O-(-)-SOD system in all the cell compartments studied in tumor-bearing animals. (msk.ru)
  • RATIONALE: GW786034 may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and by stopping blood flow to the tumor. (bioportfolio.com)
  • An Economical, Quantitative, and Robust Protocol for High-Throughput T Cell Receptor Sequencing from Tumor or Blood. (bioportfolio.com)
  • The T cell receptor repertoire provides a window to the cellular adaptive immune response within a tumor, and has the potential to identify specific and personalized biomarkers for tracking host respo. (bioportfolio.com)
  • Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. (wikipedia.org)
  • E. W. Haeffner, C. J. K. Hoffmann, M. Stoehr and H. Scherf, Cholesterol induced growth stimulation, cell aggregation and membrane properties of ascites tumor cells in culture, Cancer Res. (springer.com)
  • Ehrlich inner body - a round oxyphil body found in the red blood cell in case of hemocytolysis due to a specific blood poison. (thefreedictionary.com)
  • Lysis of autologous tumor cells by peripheral blood lymphocytes treated with interleukin 2 in patients with renal cell carcinoma. (biomedsearch.com)
  • Peripheral blood lymphocytes derived from patients with renal cell carcinoma were stimulated with interleukin 2 and tested in a 4-hour 51chromium-release cytotoxicity assay against autologous cultured tumor and myeloid K562 cells. (biomedsearch.com)
  • Since no significant correlation between the degree of cytotoxicity and the pathological findings of tumor stage, grade, cell type or lymphocyte infiltration in the tumor was found, it was impossible to predict from the pathological findings which tumor could be lysed by peripheral blood lymphocytes treated with interleukin 2. (biomedsearch.com)
  • Our results demonstrate that adoptive immunotherapy with peripheral blood lymphocytes activated by interleukin 2 in patients with renal cell carcinoma could be appropriate as a therapeutic procedure. (biomedsearch.com)
  • Renal cell carcinoma (RCC) is a tumor whose past is filled with failed treatments and unpreventable patient death. (springer.com)
  • In this chapter, we discuss one of the newest discoveries in RCC tumor immunology: T-cell coinhibition. (springer.com)
  • This chapter will first introduce key concepts of T-cell function and tumor immunology that are necessary for a good understanding of how coinhibition works. (springer.com)
  • HE-02 reduced Ehrlich tumor cell viability and peritumoral microvessels density. (mdpi.com)
  • The treatment of Ehrlich ascites carcinoma-bearing mice with complexes 1 and 2 increased the number of Annexin V positive cells and cleaved caspase-3 levels and induced changes in the cell morphology and in the cell cycle phases by induction of sub-G1 and G0/G1 cell cycle arrest. (bireme.br)
  • When the methylation status of key immune synapse genes was interrogated, we observed disproportionately hypermethylated costimulatory genes and hypomethylation of immune checkpoint genes, which were negatively associated with functional T cell recruitment to the tumor microenvironment. (jci.org)
  • Antitumour studies of this copper complex was carried out using Daltons Lymphoma Ascites cell-induced solid tumour model and Ehrlich's Ascites Carcinoma cell-induced ascites tumour model. (ijpsonline.com)
  • The mouse Ehrlich ascites tumor cell line (EAT) and a human small-cell carcinoma line (GLC4) were incubated for 4 hr at 37 degrees C, with the cross-linking agent cis-diamino-dichloro platinum (cDDP). (rug.nl)
  • S.W. Goldberg and Efim London describe the use of radium to treat two patients with basal cell carcinoma of the skin. (cancer.gov)
  • This effect may not be limited to prostate cells in that potent anti-tumor effect of fenugreek are also seen in a panel of pancreatic and breast cancer cell lines. (b92.net)
  • a decrease in the tumour volume and viable cell count in the DLA tumour hosts. (who.int)
  • and differential cell count) following MPA treatment of the tumour bearing mice. (who.int)
  • dead cell count haematological parameters and solid tumour mass was also significantly reduced. (who.int)
  • In the present study, we evaluated the ability of Gr-1 + myeloid cells, derived from the bone marrow or spleen of tumor-bearing mice, to inhibit CD3/CD28-mediated T cell activation. (jimmunol.org)
  • The proliferative response of T cells was dramatically decreased when naive T cells were activated by anti-CD3 and anti-CD28 Abs in the presence of a myeloid-enriched cell fraction derived from spleen or bone marrow of tumor-bearing mice vs the bone marrow of naive mice. (jimmunol.org)
  • Our findings suggest that one mechanism by which an increased number of immune suppressive Gr-1 + cells can induce T cell unresponsiveness or immune tolerance in tumor hosts could be through peroxynitrite production upon primary T cell activation. (jimmunol.org)
  • These studies indicate that progressive tumor growth is associated with the down-regulation of T cell responses. (jimmunol.org)
  • It has been demonstrated previously that cells expressing Gr-1 or Mac-1 myeloid lineage cell markers are involved in T cell hyporesponsiveness in tumor-bearing mice. (jimmunol.org)
  • The freshly drawn fluid was diluted with ice-cold normal saline (0.9 %) and tumor cell number was adjusted to 2x10 6 cells/ml for inoculation. (ispub.com)
  • All groups were treated with EAC ascetic carcinoma cell lines (0.2 ml of 2x10 6 cells/mice) intraperitoneally except normal group. (ispub.com)
  • Furthermore, MT exhibited 5‑10 times higher cytotoxic activities against tumour cell lines HCT‑116, МСF‑7 and K‑562 than TR, but was less toxic than TR (LD50 of MT was 375 mg/kg, while LD50 for TR was 75 mg/kg). (spandidos-publications.com)
  • The present work was an endeavor to evaluate the influence of bee venom (BV) or its major constituent melittin (MEL) as antiapoptotic and angiogenic regulator modifier on the tumor growth and the cell sensitivity to ionizing radiation targeting the improvement of cancer therapeutic protocols. (greenmedinfo.com)
  • Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. (scialert.net)
  • Structure-activity studies on gossypol in tumor cell lines," Anticancer Drugs, 11:209-216 (2000). (patentgenius.com)
  • This metastatic suppression was accompanied by a 91% reduction of viable circulating tumor cells ( P = 0.041), suggesting that S -allylmercaptocysteine prevents dissemination by decreasing tumor cell intravasation. (aacrjournals.org)
  • Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). (scirp.org)
  • The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis. (scirp.org)
  • The intracellular accumulation of poly-γ-glutamyl derivatives of methotrexate was evaluated in the presence of vincristine or probenecid (agents which raise the intracellular level of free methotrexate) in Ehrlich ascites tumor cells. (elsevier.com)
  • These studies (a) indicate that vincristine and probenecid may be potentially useful for selectively increasing methotrexate polyglutamates in tumor cells and (b) introduce another basis for synergism observed between alkaloids and methotrexate. (elsevier.com)
  • Fry, DW, Yalowich, JC & Goldman, ID 1982, ' Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells ', Cancer Research , vol. 42, no. 7, pp. 2532-2536. (elsevier.com)
  • Mechanism of growth inhibitory effect of cape aloe extract in ehrlich ascites tumor cells. (curehunter.com)
  • Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells. (curehunter.com)
  • Role of intracellular reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor cells. (curehunter.com)
  • Realizing the fact, this research was carried out to evaluate the antioxidant and anticancer activity of Ethanolic Extract of Artemisia nilagirica (Clarke) against Ehrlich Ascites Carcinoma (EAC) in mice model. (ispub.com)
  • The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg -1 body weight intraperitoneally. (scialert.net)
  • The extract/fraction also decreased the body weight of the EAC tumor bearing mice. (scialert.net)
  • Ehrlich's tumor is maintained in the Immunophysiology laboratory of UFMA, through weekly intraperitoneal transplantation of tumor cells (2 × 10 6 /animal) in healthy Swiss mice. (biomedcentral.com)
  • The antitumor effectiveness of the [Ru(l-Met)(bipy)(dppb)]PF (1) and the [Ru(l-Trp)(bipy)(dppb)]PF (2) complexes were evaluated in the peritoneal carcinomatosis model, Ehrlich ascites carcinoma-bearing Swiss mice. (bireme.br)
  • Data of biodistribution studies, performed by intravenous injections in Swiss mice bearing Ehrlich carcinoma cells, showed that SPB has poor uptake in tumor region. (worldwidescience.org)
  • Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption. (greenmedinfo.com)
  • To establish a more efficient treatment for immunotherapy against solid tumors, we have evaluated the antitumor effect by coexpression of a chemokine CCL21/secondary lymphoid tissue chemokine and a costimulatory molecule LIGHT in colon carcinoma C26. (ebscohost.com)
  • Immunotherapy in Tumors. (springermedizin.de)
  • The cells of Ehrlich ascites (EACs) tumor were obtained from National Cancer Institute (Cairo, Egypt). (hindawi.com)
  • D. E. Brennemann, L. McGee and A. A. Spector, Cholesterol metabolism in the Ehrlich ascites tumor, Cancer Res. (springer.com)
  • Tumor growth is accompanied by an increase in the number of immature myeloid cells having strong natural suppressive activity, in BM as well as peripheral lymphoid organs in cancer patients ( 6 , 7 ) or tumor-bearing mice ( 8 , 9 , 10 ). (jimmunol.org)
  • In parallel experiments, an identical low-molecular-weight fraction that impairs the type II interferon induction in mice was isolated from the ascitic fluids of rats bearing AH-100B ascites tumor and from a human hepatoma case with advanced cancer metastatic to the peritoneal cavity. (aacrjournals.org)
  • 29 Even so, women who develop breast cancer while using HRT at the time of diagnosis have a similar prognosis in terms of type, size, or grade of tumor as that of nonusers. (glowm.com)
  • Cancer immunoediting: from immunosurveillance to tumor escape. (springermedizin.de)
  • There is epidemiologic evidence that high garlic consumption decreases the incidence of prostate cancer, and compounds isolated from garlic have been shown to have cancer-preventive and tumor-suppressive effects. (aacrjournals.org)
  • We used a newly established fluorescent orthotopic androgen-independent prostate cancer mouse model to assess the ability of S -allylmercaptocysteine to inhibit tumor growth and dissemination. (aacrjournals.org)
  • Despite the widespread presence of clinically insignificant tumors in elderly men, prostate cancer commonly has an aggressive phenotype that requires prompt intervention ( 2 ). (aacrjournals.org)
  • The second part was the assessment of the antitumor activity of NBPQD by estimating the tumor volume and the contents of total protein, total lipid, DNA and RNA in liver tissues. (scirp.org)
  • Abnormal blood vessels and hypoxic and necrotic regions are common features of solid tumors and related to the malignant phenotype and therapy resistance. (bioportfolio.com)
  • He reports that two of seven children born to a father who was successfully treated for childhood retinoblastoma, a malignant tumor of the eye, also developed the disease. (cancer.gov)
  • Medulloblastoma is a malignant brain tumor that occurs predominantly in children. (cancerjournal.net)
  • Tumor-infiltrating fibroblasts are a heterogeneous population, and different subpopulations play differential roles in tumor microenvironment. (bioportfolio.com)
  • The preparation of the anti-tumor substance is far superior in the anti-tumor activity to that of water-soluble fraction and has less inflammation-, feverand paincausing properties than any ones of prior art. (google.com)
  • While the preparations obtained by these methods are superior in their anti-tumor activity, they are not desirable in viewpoint of the form of preparation. (google.com)
  • All of the anti-tumor preparations prepared according 3,786,141 Patented Jan. 15, 1974 to the above processes come from water-soluble fractions of the cells of the Streptococci, and their anti-tumor activity is not sufficient as compared with that of PCB-45 which is a preparation of streptococcal cells. (google.com)
  • The aim of the present work was to synthesise coumarinyl heterocycles and to elucidate the potential role of these compounds as antioxidants and cytotoxic agents against Dalton's lymphoma ascites tumour cells (DLA) and Ehrlich ascites carcinoma cells (EAC). (srce.hr)
  • Comparison of glutathione reductase activity and the intracellular glutathione reducing effects of 13 derivatives of 1'-acetoxychavicol acetate in Ehrlich ascites tumor cells. (curehunter.com)
  • Tumor volume and DNA, RNA, urea and malondialdehyde (MDA) levels and the liver enzymes activity were highly significantly increased (P (scirp.org)
  • The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). (hindawi.com)
  • In addition, the anticancer activity of these complexes against Ehrlich ascites tumor cells (EACs) has been reported. (hindawi.com)
  • From the kinetics study the lysis of autologous tumor cells was detectable on day 2 of interleukin 2 exposure and the peak activity was observed on day 5. (biomedsearch.com)
  • According to Petering [ 10 ], Cu(II) ion alone will not have any antitumour activity, but will act as an inhibitor of tumour growth in the chelated form. (ijpsonline.com)
  • The synthetic amides of L-glutamic acid also exhibited activity against Ehrlich ascites carcinoma [ 6 ]. (ijpsonline.com)
  • Telomerase activity in human ovarian carcinoma," Proc. (freepatentsonline.com)
  • A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas. (cancerjournal.net)
  • One of their main properties in this regard is their antioxidant activity, which enables them to attenuate the development of tumor and inflammatory disease. (ispub.com)
  • Ehrlich anemia - anemia resulting from hypoplastic or aplastic bone marrow. (thefreedictionary.com)
  • Using flow cytometry, we found that growth of a murine colon carcinoma (MCA-26) induces a significant increase in the number of Gr-1 + and Gr-1 + /Mac-1 + myeloid cells in both bone marrow and spleen of the tumor host. (jimmunol.org)
  • Paul Ehrlich proposes that the immune system usually suppresses tumor formation, a concept that becomes known as the "immune surveillance" hypothesis. (cancer.gov)
  • Finally, we propose a model to explain why certain renal tumors are eliminated by the immune system and others are not. (springer.com)
  • Tumor cells express immune synapse proteins to suppress the immune system, which is often modulated by epigenetic mechanisms. (jci.org)
  • Tumor cells can escape from the attack by the immune system through various mechanisms, including immune evasion, immune suppression, or both. (jimmunol.org)
  • Tumor biopsies will also be used to assess the mechanisms of resistance to PARP inhibitor-based therapy. (bioportfolio.com)
  • The objective of this study was to analyze whether duloxetine influences tumor growth in Ehrlich carcinoma. (biomedcentral.com)
  • In conclusion, duloxetine has no direct effect on tumor growth and does not alter immunity. (biomedcentral.com)
  • The study on the effect of adjuvants is important to select drugs that do not increase tumor growth. (biomedcentral.com)
  • The present study aimed to evaluate whether duloxetine directly influences tumor growth, in the Ehrlich's tumor model in mice. (biomedcentral.com)
  • RATIONALE: S-3304 may stop or slow the growth of solid tumors by stopping blood flow to the tumor. (bioportfolio.com)
  • RATIONALE: Drugs used in chemotherapy, such as SJG-136, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. (bioportfolio.com)
  • C.molmol inhibits the growth of Ehrlich carcinoma cells in mice (4) . (mskcc.org)
  • Glutamine-analogue acivicin inhibits tumor growth and tumor-induced angiogenesis in Ehrlich ascites carcinoma. (niscair.res.in)
  • Progesterone accelerates the appearance, growth rate, and number of tumors in carcinogen-induced rat mammary cancers. (glowm.com)
  • Experimental tumors have nice importance for the needs of modeling, and one among the most typical is that the bacteriologist pathology tumor, that springs from a spontaneous murine exocrine gland carcinoma [4]. (scirp.org)
  • Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Paul-Ehrlich-Straße 42-44, D-60596 Frankfurt, Germany. (nih.gov)
  • 0.05) in mice bearing Ehrlich's ascites carcinoma cells, with apparent regression of tumor volume in comparison with mice treated with bulk doses with CDDP. (dovepress.com)
  • For metastatic disease, the initial medical treatment is androgen deprivation, which induces tumor regression and reduction in serum prostate-specific antigen in 80% to 85% of cases. (aacrjournals.org)
  • Gurevich S.M., Vartanian L.S., Nagler L.G., Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their normalization under the effect of ruboxyl, Voprosy meditsinskoi khimii, 1993, vol: 39(6), 16-20. (msk.ru)
  • 2007) Molecular definition of breast tumor heterogeneity. (scirp.org)
  • E. W. Haeffner, K. Kolbe, D. Schroeter and N. Paweletz, Plasma membrane heterogeneity in ascites tumor cells. (springer.com)
  • The Spatial Metabolic Heterogeneity of Solid Type of Enrlich Carcinoma. (nih.gov)
  • In addition, these complexes reduce angiogenesis induced by Ehrlich ascites carcinoma cells in chick embryo chorioallantoic membrane model. (bireme.br)
  • Role of Bee Venom and Melittin on Restraining Angiogenesis and Metastasis inγ-Irradiated Solid Ehrlich Carcinoma-Bearing Mice. (greenmedinfo.com)
  • Also, the effect of 2-mercaptopyrimidine-5-carboxylic acid and S-analogy of pyrimidinic bases on oral epidermoid human carcinoma (KB) have been reported [ 10 , 11 ]. (hindawi.com)
  • The cytotoxic activities appear to be as effective as cyclophosphamide in solid tumor-bearing mice. (mskcc.org)
  • Conclusion: Novel strategies focused towards targeting drug substances specifically to brain tumor site would increase the therapeutic efficiency and reduce the toxicity of chemotherapeutics. (eurekaselect.com)
  • To achieve better therapeutic effect by immune modulating therapy, it is important to study the mechanisms of tumor-induced immune suppression. (jimmunol.org)
  • Despite the increasing knowledge about the molecular basis of tumor development, few advances have been reached in clinical therapy and diagnoses, which shows the importance of new drugs development for therapeutic and diagnosis purpose. (worldwidescience.org)
  • Therapeutic application of tryptanthrin-containing topical preparations in Chinese folk medicine ( 4 ) confirmed its potent anti-inflammatory action as well as anti-tumour and antimicrobial activities, particularly against mycobacteria and pathogenic protozoa, including malaria plasmodia ( 5 - 8 ). (spandidos-publications.com)
  • Bee venom and its major constituent melittin might represent a potential therapeutic strategy for increasing the radiation response of solid tumors. (greenmedinfo.com)
  • The high oncotic pressure in tumors is consistent with the elevated interstitial fluid pressure, and it contributes to the suboptimal delivery of large therapeutic agents to neoplastic cells. (aacrjournals.org)
  • To study the effect of ACD on the healing rate of full-thickness cutaneous wound in rats after cisplatin (CP) administration, and on a complicated wound process in Guerin's carcinoma-bearing rats after a CP course followed by tumor resection. (exp-oncology.com.ua)
  • Surgery is risky because extracting the tumors can permanently damage the brain and alter the patient's ability to function. (eurekaselect.com)
  • Theodor Boveri proposes that cancerous tumors arise from single cells that have experienced chromosome damage and suggests that chromosome alterations cause the cells to divide uncontrollably. (cancer.gov)
  • The Iowa Women's Health Study found a longer duration of HRT was associated with increased risk of invasive carcinoma with a favorable histology, with a relative risk (RR) of 1.81 for HRT use of less than five years duration versus a RR of 2.65 for use longer than five years. (glowm.com)
  • The induction of Ehrlich ascites carcinoma in mice led to alterations in hematological and biochemical parameters, and not the treatment with complexes 1 and 2. (bireme.br)
  • It was observed that TF/EGCG encapsulated PLGA nanoparticles (NPs) offered an up to ~7-fold dose advantage when compared with bulk TF/EGCG in terms of exerting its antiproliferative effects and also enhanced the anticancer potential of cisplatin (CDDP) in A549 (lung carcinoma), HeLa (cervical carcinoma), and THP-1 (acute monocytic leukemia) cells. (dovepress.com)