The interaction of rhodium(II) carboxylates with enzymes. (1/1023)
The effect of rhodium(II) acetate, propionate, and methoxyacetate on the activity of 17 enzymes was evaluated. The enzymes were preincubated with the rhodium(II) complexes in order to detect irreversible inhibition. All enzymes that have essential sulfhydryl groups in or near their active site were found to be irreversibly inhibited. Those enzymes without essential sulfhydryl groups were not affected. In each case, the rate of inactivation closely paralleled the observed toxicity and antitumor activity of rhodium(II) carboxylates; that is, rhodium(II) propionate greater than rhodium(II) acetate greater than rhodium(II) methoxyacetate. In addition, those enzymes that have been demonstrated to be most sensitive to established sulfhydryl inhibitors, such as glyceraldehyde-3-phosphate dehydrogenase, were also most sensitive to rhodium(II) carboxylate inactivation. Proton nuclear magnetic resonance measurements made during the titration of rhodium(II) acetate with cysteine showed that breakdown of the carboxylate cage occurred as a result of reaction with this sulfhydryl-containing amino acid. (+info)Action of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver. (2/1023)
The effects of partially thiolated polynucleotides on the DNA polymerase alpha from regenerating rat liver were investigated. The enzyme was isolated from the nuclear fraction essentially according to the method of Baril et al.; it was characterized as the alpha polymerase on the basis of its response to synthetic templates and its inhibition with N-ethylmaleimide. Although polycytidylic acid had no effect on the DNA polymerase alpha either as a template or as an inhibitor, partially thiolated polycytidylic acid (MPC) was found to be a potent inhibitor, its activity being directly related to its extent of thiolation (percentage of 5-mercaptocytidylate units in the polymer). In comparison, the DNA polymerase beta which was purified from normal rat liver nuclear fraction, was much less sensitive to inhibition by MPC. Analysis of the inhibition of the alpha polymerase by the method of Lineweaver and Burk showed that the inhibitory action of MPC was competitively reversible with the DNA template, but the binding of the 7.2%-thiolated MPC to the enzyme was much stronger than that of the template (Ki/Km less than 0.03). Polyuridylic acid as such showed some inhibitory activity which increased on partial thiolation, but the 8.4%-thiolated polyuridylic acid was less active than the 7.2% MPC. When MPC was annealed with polyinosinic acid, it lost 80% of its inhibitory activity in the double-stranded configuration. However, 1 to 2%-thiolated DNA isolates were significantly more potent inhibitors than were comparable (1.2%-thiolated) MPC and showed competitive reversibility with the unmodified (but "activated") DNA template. These results indicate that the inhibitory activities of partially thiolated polynucleotides depend not only on the percentage of 5-mercapto groups but also on the configuration, base composition, and other specific structural properties. (+info)Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells. (3/1023)
A monoclonal antibody (mAb; A10) raised against murine Ehrlich tumor cell surface carbohydrates was tested for reactivity with human normal and malignant tissues. A10 reacted strongly, with a high proportion of adenocarcinomas arising from colon and other tissues but not with breast carcinomas or other malignant tumors. Normal tissues were virtually A10 unreactive, except for the duct cells from breast and pancreas and some bronchial mucosae. Ultrastructural studies showed mAb A10 immunolabeling of both microvilli and mucin droplets in colon cancer cells but not in normal absorptive or globet cells. A10 reacted strongly with mucin-enriched fractions from colon cancer tissues and HT-29 xenografts but not from normal colon tissues. A10 epitope was carried on MUC1 derived from colon adenocarcinomas and probably on other mucin species, although not on MUC2 molecules. A10 epitope was resistant to exoglycosidases and periodate oxidation but sensitive to the Smith's degradation and beta-elimination, suggesting the involvement of O-linked carbohydrates in nonterminal reducing positions. A mucin-type glycosidic linkage was supported because of the lack of A10 reactivity with HT-29 cells grown with phenyl-N-acetyl-alpha-D-galactosaminide. Deglycosylation studies with trifluoromethanesulfonic acid pointed to the involvement of core mucin glycans in the A10 epitope. This epitope was resistant to protease, O- and N-glycanase treatments carried out on trifluoromethanesulfonic acid-deglycosylated mucins. Inhibition studies with core 1, core 2, core 3, and core 6 suggested the latter [GlcNAcbeta(1-6)GalNAc] as being involved in A10 epitope. Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer. (+info)Phospholipid metabolism in ehrlich ascites tumor cells. II. Turnover rate of ether phospholipids. (4/1023)
1. Radioactive precursors of phospholipids, i.e., 32Pi, [1-14C]glycerol, [2-3H]glycerol, and [1-14C]acetate, were individually injected into the peritoneal cavity of mice bearing Ehrlich ascites tumor cells and the rates of incorporation were estimated. 2. Although [2-3H]glycerol was not practically incorporated into ether phospholipids, the other three radioactive precursors were incorporated into diacyl, 1-O-alkenyl-2-acryl-, and 1-O-alkyl-2-acryl-GPE (GPC). 3. In the experiments on 32Pi or [1-14C]acetate incorporation, 1-O-alkyl compounds in the ethanolamine phosphoglyceride fraction showed high specific activities in comparison with 1-acyl compounds. In the case of [1-14C]glycerol incorporation, a high rate of incorporation into 1-O-alkyl compounds was not found. In the choline phosphoglyceride fraction, a high rate of incorporation of the above precursors into 1-O-alkyl compounds was not observed. 4. The specific activities of 1-O-alkenyl compounds were fairly low compared with those of 1-acyl- and 1-O-acyl- and 1-O-alkyl compounds throughout the incorporation experiments with [1-14C]glycerol and [1-14C]acetate, but in 32Pi incorporation, 1-O-alkenyl compounds showed higher specific activities than 1-acyl compounds in ethanolamine phosphoglyceride, suggesting an exchange reaction of the phosphorylethanolamine moiety. 5. From the above findings, it appears that alkyl ether phospholipids of ethanolamine from may have a significant role in ascites tumor cells, based on their rapid turnover. (+info)Isolation of ekatetrone, a new metabolite of producing variants of Streptomyces aureofaciens. (5/1023)
From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of Ehrlich's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis. (+info)New semisynthetic vinca alkaloids: chemical, biochemical and cellular studies. (6/1023)
A new semisynthetic anti-tumour bis-indol compound, KAR-2 [3'-(beta-chloroethyl)-2',4'-dioxo-3,5'-spiro-oxazolidino-4-dea cetoxy-vinblastine] with lower toxicity than vinca alkaloids used in chemotherapy binds to calmodulin but, in contrast to vinblastine, does not exhibit anti-calmodulin activity. To investigate whether the modest chemical modification of bis-indol structure is responsible for the lack of anti-calmodulin potency and for the different pharmacological effects, new derivatives have been synthesized for comparative studies. The synthesis of the KAR derivatives are presented. The comparative studies showed that the spiro-oxazolidino ring and the substitution of a formyl group to a methyl one were responsible for the lack of anti-calmodulin activities. The new derivatives, similar to the mother compounds, inhibited the tubulin assembly in polymerization tests in vitro, however their inhibitory effect was highly dependent on the organization state of microtubules; bundled microtubules appeared to be resistant against the drugs. The maximal cytotoxic activities of KAR derivatives in in vivo mice hosting leukaemia P388 or Ehrlich ascites tumour cells appeared similar to that of vinblastine or vincristine, however significant prolongation of life span could be reached with KAR derivatives only after the administration of a single dose. These studies plus data obtained using a cultured human neuroblastoma cell line showed that KAR compounds displayed their cytotoxic activities at significantly higher concentrations than the mother compounds, although their antimicrotubular activities were similar in vitro. These data suggest that vinblastine/vincristine damage additional crucial cell functions, one of which could be related to calmodulin-mediated processes. (+info)Heterogeneity of native ribosomal 60-S subunits in Ehrlich ascites tumor cells cultured in vitro. (7/1023)
Native large ribosomal subunits in cultured Ehrlich ascites tumor cells analyzed by high-resolution CsCl isopycnic centrifugation consist of at least two classes of particles with densities of 1.57 g/cm3 (LI) and 1.59 g/cm3 (LII), respectively. A wash with 0.5 M KCl converts LI into particles with the density of LII particles. Incubation of derived large subunits (density 1.59 g/cm3) with 0.5 M KCl wash of reticulocyte ribosomes leads to the formation of particles with the density of LI particles. A protein with a molecular weight of 57000 present in the high-KCl wash of 60-S native subunits was virtually absent in the KCl wash of 40-S subunits or polyribosomes suggesting that specific protein factors may be present on some native 60-S subunits. Possible functions of these protein factors are discussed. (+info)Glyceraldehyde-3-phosphate dehydrogenase from Ehrlich ascites carcinoma cells its possible role in the high glycolysis of malignant cells. (8/1023)
Glyceraldehyde-3-phosphate dehydrogenase has been purified to apparent homogeneity from Ehrlich ascites carcinoma (EAC) cells. The enzyme is quite active over a pH range of 7.5-9.0 with an optimum pH of 8.4-8.7. The specific activity of the enzyme is much higher than that from other normal sources. In contrast to enzyme obtained from rabbit muscle, the EAC cell enzyme is not significantly inhibited by physiological concentrations of ATP at physiological pH. Kinetic studies using different substrates and inhibitors indicate that the properties of the EAC cell enzyme are significantly different from those of glyceraldehyde-3-phosphate dehydrogenase obtained from other normal sources. The striking dissimilarity of the malignant cell glyceraldehyde-3-phosphate dehydrogenase compared with this enzyme from other normal sources, particularly in respect to the interaction with ATP, may in part explain the high glycolysis of malignant cells. (+info)
B-1 cells and concomitant immunity in Ehrlich tumour progression
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Ehrlich ascites carcinoma
Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. It was originally established as an ascites tumor in mice ... The tumor was cultured in vivo, which became known as the Ehrlich cell. After 1948 Ehrlich cultures spread around research ... Dupre, Ann M.; Hempling, H. G. (December 1978). "Osmotic properties of ehrlich ascites tumor cells during the cell cycle". ... ". "Ehrlich Cells (Molecular Biology)". DuPre, AM; Hempling, HG (1978). "Osmotic properties of ehrlich ascites tumor cells ...
Katarína Horáková
"Sacharose density gradient separation of Ehrlich ascites carcinoma and L-5178Y tumor cells in different cell cycle phases". ... Interference of Bruneomycin with the Cell Cycle of Ehrlich's Ascites Carcinoma]. Biológia (in Slovak). 35 (12): 875-80. ... Horáková, K (1975). "Ribonucleases in mouse ascitic tumor cells during ageing in vivo and in vitro". Advances in Experimental ... Horáková, K (1972). "Polynucleotidases in mouse ascitic tumour cells". Neoplasma. 19 (5): 459-68. PMID 4345214. Fuska, JAN; ...
Pterocarpus indicus
This property might be due to an acidic polypeptide found in its leaves that inhibited growth of Ehrlich ascites carcinoma ... In folk medicine, it is used to combat tumors. ...
Fawzia Fahim
Mady, E. A. (2002). "Antitumor and biochemical effects of Echis coloratus crude venom on Ehrlich ascites carcinoma cells in ... "Role of dietary magnesium and/or manganese variables on ehrlich ascites tumor‐bearing mice". Nutrition and Cancer. 12 (3): 279- ... "Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ...
Gerhard Domagk
Ehrlich carcinoma and Crocker sarcoma of mice and the Walker carcinoma of rats. He was aware that precision drugs would be ... even if the tumor cannot be completely eliminated. We will be satisfied if we ca slow down it growth, in order to preserve the ... Later, Ehrlich and his students found that some azo dyes were effective against African sleeping sickness. In 1913, P. ... For example, German biologist Paul Ehrlich used methylene blue, a type of azo dye, to kill malarial parasites in experimental ...
Iodoacetic acid
"Antitumor Activities of Iodoacetate and Dimethylsulphoxide Against Solid Ehrlich Carcinoma Growth in Mice". Biological Research ... Apffel, C. A.; Arnason, B. G.; Peters, J. H. (1966). "Induction of tumour immunity with tumour cells treated with iodoacetate ... Several studies have shown iodoacetate has anti-tumor effects. In 2002 Dr. Fawzia Fahim showed that "a single IAA treatment of ... In 1966 Charles A. Apffel, Barry G. Arnason & John H. Peters showed anti-tumor activity for iodoacetate. Iodide is a naturally ...
Patrick S. Moore
"Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma". Journal of ... the 2017 Paul Ehrlich and Ludwig Darmstaedter Prize and the 2017 Passano Award. They are 2017 Clarivate Citation Laureates. " ... In 1994, they discovered a new human herpesvirus, KSHV, in a KS tumor and along with several collaborators showed that it was ... His laboratory currently seeks to understand the role of tumor virus immunoevasion of the innate immune system as a cause for ...
Sp1 transcription factor
"Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 ... September 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". ...
Stuart A. Aaronson
His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming ... Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/ ... 1982 Rhoads Memorial Award 1982 PHS Meritorious Service Medal 1989 Paul Ehrlich Award 1989 PHS Distinguished Service Medal 1990 ... "Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma". ...
Aflatoxin B1
These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, a tumor suppressing gene, and ... Prevalence of hepatocellular carcinoma in individuals exposed to aflatoxin, increases with co-infection of hepatitis B virus. ... Yu J, Chang PK, Ehrlich KC, et al. (March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol ... Up to 44% of hepatocellular carcinomas in regions with high aflatoxin exposure bear a GC → TA transversion at codon 249 of p53 ...
Hans-Georg Rammensee
Since the late 1970s, Rammensee has been focusing on immunology with the specific aim of using tumor immunology to fight ... 2013 Paul Ehrlich and Ludwig Darmstaedter Prize, 1996 Robert Koch Prize, 1993 Gottfried Wilhelm Leibniz Prize, 1992 Heinz Maier ... The immunopeptidomic landscape of ovarian carcinomas. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9942-E9951. doi: 10.1073/ ... Rammensee has contributed essentially to the research fields of MHC biology and tumor immunology and to the development of ...
List of MeSH codes (C04)
... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... carcinoma, signet ring cell MeSH C04.557.470.200.025.415.410 - krukenberg tumor MeSH C04.557.470.200.025.420 - carcinoma, skin ... sertoli-leydig cell tumor MeSH C04.557.475.750.847.249 - leydig cell tumor MeSH C04.557.475.750.847.500 - sertoli cell tumor ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ...
IRF8
... but is significantly focally deleted across the entire dataset of 3131 tumors, suggesting that IRF8 is potentially a tumor ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (June 1995). "Functional domain analysis of interferon ... Molecular analysis indicated that the IRF8 gene promoter is hypermethylated in human colon carcinoma cells, suggesting that ... Sharf R, Azriel A, Lejbkowicz F, Winograd SS, Ehrlich R, Levi BZ (1995). "Functional domain analysis of interferon consensus ...
S100A6
"Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding ... S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma. GRCh38: Ensembl release 89: ENSG00000197956 ... "Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid ... carcinoma". Thyroid. 20 (10): 1067-76. doi:10.1089/thy.2009.0400. PMID 20629554. Schäfer BW, Heizmann CW (1996). "The S100 ...
Microsatellite instability
MSI-L tumors result from less than 30% of unstable MSI biomarkers. MSI-L tumors are classified as tumors of alternative ... MSI has been evident in the cause of sebaceous carcinomas. Sebaceous carcinomas are a subset of a larger pathology, Muir-Torre ... Ehrlich M, ed. (2000). DNA alterations in cancer: genetic and epigenetic changes. Natick, MA: Eaton Publ. p. 178. ISBN 978-1- ... MSI tumors in 15% of sporadic colorectal cancer result from the hypermethylation of the MLH 1 gene promoter, whereas MSI tumors ...
Charlotte Friend
... the two decided to look at fine structures within the cells of the Ehrlich ascites carcinoma, a commonly used model for cancer ... "The Coming of Age of Tumor Virology." Cancer Research 37 (1977): 1255-1263 "Hemoglobin Synthesis in Murine Virus-induced ...
Harald zur Hausen
"Prize Winners of the Paul Ehrlich and Ludwig Darmstaedter Prize" (PDF). uni-frankfurt.de. The Paul Ehrlich Foundation. ... This discovery paid off several years later, in 1983, when zur Hausen identified HPV 16 DNA in cervical cancer tumors by means ... M Dürst; L Gissmann; H Ikenberg; H zur Hausen (1 June 1983). "A papillomavirus DNA from a cervical carcinoma and its prevalence ... Paul Ehrlich and Ludwig Darmstaedter Prize (1994) International member of the American Philosophical Society (1998) Virchow ...
Fibroblast growth factor 8
... the ability for FGF8 to regulate cell proliferation has caused interest in its effects on tumors or squamous cell carcinoma. ... Gemel J, Gorry M, Ehrlich GD, MacArthur CA (July 1996). "Structure and sequence of human FGF8". Genomics. 35 (1): 253-7. doi: ... Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene was ... This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. ...
Christian Bréchot
Hepatitis C virus core variants isolated from liver tumor but not from adjacent non tumor interact with Smad3 and inhibit the ... doi: 10.1002/hep.24087 Arumugam M, Raes J, Brechot C, Merieux A, Weissenbach J, Ehrlich SD, Bork P. Enterotypes of the human ... hepatocellular carcinoma, HCC), as well as the molecular mechanisms underpinning liver regeneration and cancer (especially the ... Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation. ...
RAGE (gene)
"Renal cell carcinoma antigen is expressed by yolk sac tumors and yolk sac elements of embryonal carcinomas". Applied ... Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A (May ... Götte K, Usener D, Riedel F, Hörmann K, Schadendorf D, Eichmüller S (July 2002). "Tumor-associated antigens as possible targets ... "Entrez Gene: RAGE renal tumor antigen". Eichmüller S, Usener D, Jochim A, Schadendorf D (August 2002). "mRNA expression of ...
RBBP8
It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants ... Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni- ... in breast carcinomas". Int. J. Cancer. 107 (1): 155-8. doi:10.1002/ijc.11343. PMID 12925972. S2CID 20908722. Dick FA, Sailhamer ... "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. ...
Jun dimerization protein
... of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma". The ... Ji H, Ehrlich LI, Seita J, Murakami P, Doi A, Lindau P, et al. (September 2010). "Comprehensive methylome map of lineage ... JDP2 shows the gene amplification of head and neck squamous-cell carcinoma. In pancreatic carcinoma, downregulation of JDP2 is ... July 2005). "Tumor model-specific proviral insertional mutagenesis of the Fos/Jdp2/Batf locus". Virology. 337 (2): 353-364. doi ...
Rudolf Virchow
It is now believed that the Kaiser had hybrid verrucous carcinoma, a very rare form of verrucous carcinoma, and that Virchow ... Experiments also show that drugs that block inflammation simultaneously inhibit tumour formation and development. Virchow was ... and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic pathology there. One of Virchow's ... Metastasis was first described by Karl Thiersch in the 1860s.) He made a crucial observation that certain cancers (carcinoma in ...
Bert Vogelstein
"Prize Winners of the Paul Ehrlich and Ludwig Darmstaedter Prize" (PDF). The Paul Ehrlich Foundation. Retrieved 17 October 2022 ... The first analyzed tumors included those of the colon, breast, pancreas, and brain. These studies outlined the landscapes of ... April 1989). "Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas". Science. 244 (4901): 217-21. Bibcode: ... The Paul Ehrlich and Ludwig Darmstaedter Prize from the Paul Ehrlich Foundation 1998 - The William Allan Award from the ...
Louise Pearce
... the Brown-Pearce Carcinoma. They studied transmission of the tumor by inoculating a series of more than twenty other rabbits, ... Building on the work of Paul Ehrlich in Germany, who had developed an arsenic-derived drug called Salvarsan for the treatment ... While the fundamental nature of the tumor remained the same, its malignancy varied. They attempted to understand the ... Because it was thoroughly studied, and replicable, the Brown-Pearce tumor became a standard test material in cancer ...
CDKN1B
In ovarian cancer, p27 negative tumors progressed in 23 months compared to 85 months in p27 positive tumors and thus could be ... In hepatocellular carcinoma cells p27 co-localizes with actin fibers to act on GTPase Rac and induce cell migration. In breast ... Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI (November 2000). "Disruption of TGF-beta growth ... In most cancers reduced levels of nuclear p27 are correlated with increased tumor size, increased tumor grade, and a higher ...
Ludwik Gross
... (September 11, 1904 - July 19, 1999) was a Polish-American virologist who discovered two different tumor viruses- ... Principal 1978 Paul Ehrlich-Ludwig Darmstaeder Prize in Frankfurt Griffuel Prize in Paris (1978) Elected to the National ... murine polyomavirus is closely related to the human Merkel cell polyomavirus that causes most forms of Merkel cell carcinoma. ...
Uridine monophosphate synthase
... monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'- ... "Orotate phosphoribosyltransferase expression level in tumors is a potential determinant of the efficacy of 5-fluorouracil". ... "Effect of 5-phosphoribosyl-a-pyrophosphate on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells made permeable ... phosphate decarboxylase enzyme complex from mouse Ehrlich ascites cells". The Journal of Biological Chemistry. 254 (4): 1143-50 ...
Ras GTPase
Another tumor-lysing virus that specifically targets tumor cells with an activated Ras pathway is a type II herpes simplex ... Rotblat B, Ehrlich M, Haklai R, Kloog Y (2008). "The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the ... Parada LF, Tabin CJ, Shih C, Weinberg RA (June 1982). "Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ... The tumour suppressor gene NF1 encodes a Ras-GAP - its mutation in neurofibromatosis will mean that Ras is less likely to be ...
Gap junction
Ehrlich, HP; Diez, T (2003). "Role for gap junctional intercellular communications in wound repair". Wound Repair Regen. 11 (6 ... Prutkin L (February 1975). "Mucous metaplasia and gap junctions in the vitamin A acid-treated skin tumor, keratoacanthoma". ... "Gap junction blockage interferes with neuronal and astroglial differentiation of mouse P19 embryonal carcinoma cells". Dev. ... May 1996). "Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy". J. ...
Lactococcus lactis
Tumor-suppressor through Tumor metastasis-inhibiting peptide KISS1 Another study, led by Zhang B, created a L. lactis strain ... Bolotin A, Quinquis B, Renault P, Sorokin A, Ehrlich SD, Kulakauskas S, Lapidus A, et al. (2004). "Complete sequence and ... Lactococcus lactis NZ9000 secretes a bioactive kisspeptin that inhibits proliferation and migration of human colon carcinoma HT ... In addition, it was demonstrated that tumor growth can be inhibited by the LAB strain itself due to the LAB's ability to ...
Chemotherapy
Blood vessels in tumors are very different from those seen in normal tissues. As a tumor grows, tumor cells furthest away from ... The term was coined in the early 1900s by Paul Ehrlich as meaning any use of chemicals to treat any disease (chemo- + -therapy ... such as one in which a female pharmacist was diagnosed with papillary transitional cell carcinoma. Twelve years before the ... The newly formed tumor vasculature is poorly formed and does not deliver an adequate blood supply to all areas of the tumor. ...
Uğur Şahin
"Definition of tumor-associated antigens in hepatocellular carcinoma". Cancer Epidemiology. 9 (3): 285-290. ISSN 1055-9965. PMID ... Paul Ehrlich and Ludwig Darmstaedter Prize "Ehrendoktorwürde für Özlem Türeci und Uğur Şahin". Philipps-Universität Marburg (in ... This technology relies on targeting tumor-specific mutations that are not present in normal cells. Each patient's tumor has a ... They discovered tumor antigens relevant for treatment of various types of cancers, e.g. stomach cancer, pancreatic cancer, ...
Henrietta Lacks
Robert L. Ehrlich, Jr. (Extension of Remarks - June 4, 1997)", Congressional Record 105th Congress (1997-1998), The Library of ... "Henrietta's Tumor", RadioLab segment featuring Deborah Lacks and audio of Skloot's interviews with her, and original recordings ... "Squamous Cell Carcinoma". Skin Cancer Foundation. Retrieved December 31, 2016. Skloot 2010, p. 27. World Cancer Report 2014. ... Adenocarcinomas are a type of cancerous tumor or an abnormal growth of epithelial tissue. 10% to 15% of cancers of the cervix ...
FAM149A
... pancreatic tumors, colorectal tumors, and ovarian tumors. FAM149A has two transcription variants, transcript variant 1 and ... Xu X, Tsumagari K, Sowden J, Tawil R, Boyle AP, Song L, Furey TS, Crawford GE, Ehrlich M (December 2009). "DNaseI ... "Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and ... From the information in the second table, common complications involving FAM149A expression include adrenal tumors, ...
Peter M. Howley
From 1984 to 1993 he was Chief of the NIC's Laboratory of Tumor Virus Biology. In 1993 he became a professor of pathology at ... Paul Ehrlich and Ludwig Darmstaedter Prize (also awarded to Harald zur Hausen) 1996 - Fellow of the American Academy of Arts & ... "The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines". Proceedings of the National Academy of ... simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between ...
Reproductive toxicity
Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, et al. (August 2014). "Bisphenol a and reproductive health: update ... Bisphenol A exposure in fetal female rats leads to mammary gland morphogenesis, increased formation of ovarian tumors, and ... exposed to diethylstilbestrol in utero during the first trimester have are more likely to develop clear cell vaginal carcinoma ...
C-Raf
Although c-Raf is very clearly capable of mutating into an oncogene in experimental settings, and even in a few human tumors, ... Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni- ... such as renal cell carcinoma and melanoma. Several other molecules followed up, such as Vemurafenib, Regorafenib, Dabrafenib, ... The latter became the focus of research in recent years, since a large portion of human tumors carry oncogenic 'driver' ...
Liver biopsy
Direct biopsy of tumors of the liver may aid the diagnosis, although this may be avoided if the source is clear (e.g. spread ... The first liver aspirate was performed by the German physician Paul Ehrlich in 1883. In 1923, the first report of percutaneous ... Multiphasic MRI is useful in diagnosing various types of liver lesions such as hepatocellular carcinoma, cholangiocarcinoma, ...
Gremlin (protein)
Ehrlich, Brian D. Harfe, Steven A. Vokes. Dynamics of BMP signaling in limb bud mesenchyme and polydactyly (2014) Developmental ... and sarcoma carcinomas. More specifically, the Grem1 binding site (between residues 1 to 67) interacts with the binding protein ... "Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor ...
Keratin 5
It can also serve as a marker of basal cell carcinoma, transitional cell carcinoma, salivary gland tumors, and thymoma. The ... Ehrlich P, Sybert VP, Spencer A, Stephens K (May 1995). "A common keratin 5 gene mutation in epidermolysis bullosa simplex-- ... Studies on lung cancer have also shown that squamous cell carcinomas give rise to tumors with elevated K5 levels, and that they ... This process has a large role in tumor progression and metastasis since it helps enable tumor cells to travel throughout the ...
IMSEAR at SEARO: Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma.
Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma. Indian Journal of ... Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma. ... enhanced anti-tumor efficacy against Ehrlich ascites carcinoma. ... Anti-tumor efficacy of Centchroman formulated as niosomes and ... gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given ...
Ehrlich carcinoma | GreenMedInfo | Disease | Natural Medicine
Tumors,Iodine,Lectin-Induced Cancer,Vegetables: All,Thyroid Cancer,Fruit: All,Fruit: All ... Diseases : Ehrlich carcinoma. Pharmacological Actions : Antioxidants, Apoptotic, Superoxide Dismutase Up-regulation, Tumor ... Potential anti-tumor activity of kefir-induced juglone and resveratrol fractions against ehrlich ascites carcinoma.Dec 31, 2019 ... Diseases : Breast Cancer, Ehrlich carcinoma. Pharmacological Actions : Antiproliferative , Apoptotic, Tumor Suppressor Protein ...
Merkel Cell Carcinoma and Rare Appendageal Tumors: Overview, Tumors of the Epidermis, Tumorlike Lesions of Fibrous or Elastic...
Cutaneous tumors encompass a vast array of malignancies, from neuroendocrine to lymphoid. In addition to primary malignancies, ... Moyer KE, Banducci DR, Graham WP 3rd, Ehrlich HP. Dupuytrens disease: physiologic changes in nodule and cord fibroblasts ... encoded search term (Merkel Cell Carcinoma and Rare Appendageal Tumors) and Merkel Cell Carcinoma and Rare Appendageal Tumors ... clear cell carcinoma, and mucinous carcinoma. [130] All these tumors have the capacity to metastasize to skin and regional ...
FURTHER EVIDENCE FAVORING THE CONCEPT OF THE STEM CELL IN ASCITES TUMORS OF RATS | Semantic Scholar
... of tumor cells as primary contributors to the growth of the tumor. T t has been shown that in each of the tumors studied, ... eliavior of the tumor, i t is the stem (.ells which determine the genetic behavior of a tumor. Further data to tic presented in ... of tumor cells as primary contributors to the growth of the tumor and of differences in the genetic constitution of thcsc stem ... Cytological investigations based on morphological and statisticzl analysis of the chromosomes in several ascites tumors of rats ...
Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
... reactions in the tumor proliferation process by characterizing tumor growth patterns and synthesis of the RNA ribose moiet … ... Carcinoma / pathology * Carcinoma, Ehrlich Tumor / metabolism* * Cell Division / drug effects * Dehydroepiandrosterone Sulfate ... In vivo testing of 400 mg/kg OT or dehydroepiandrosterone-sulfate in C57BL/6 mice hosting Ehrlichs ascitic tumor cells ... reactions in the tumor proliferation process by characterizing tumor growth patterns and synthesis of the RNA ribose moiety in ...
RGD Reference Report - Immune modulation and apoptosis induction: Two sides of antitumoural activity of a standardised herbal...
Ehrlich tumor carcinoma treatment. ISO. RGD:708418. 11352683; 11352683. RGD. Ehrlich tumor carcinoma treatment. IDA. 11352683; ... WSF at 150mg/kg, i.p., inhibited >50% tumour growth in the mouse tumour models. In tumour-bearing mice, WSF inhibited the ... Ehrlich tumor carcinoma treatment. ISO. RGD:619830. 11352683; 11352683. RGD. ... Deregulated apoptosis and suppressed tumour reactive immunity render tumour cells to grow amok in the host body. Traditionally ...
An experimental study on the lymphatic dissemination of the solid Ehrlich tvjnor in mice
| Brazilian Journal of...
Lymphatic metastasis, Carcinoma (Ehrlich tumor), Lymph nodes, Mast cells, Mouse Abstract. Metastasis to regional lymph nodes is ... The aim of the present study was to characterize the Ehrlich tumor as a model of lymphatic metastasis in mice. Animals were ... The migration of tumor cells was detected by a biological assay as early as 1 hour post-inoculation. The solid tumor growth in ... Ehrlich tumor was considered as a suitable model for the study of lymphatic metastasis. ...
DNA Content of Nuclei and Chromosome Number in Sublines of the Ehrlich Ascites Carcinoma* | Cancer Research | American...
These findings are discussed in regard to the experimental use of ascites tumor populations. ... DNA Content of Nuclei and Chromosome Number in Sublines of the Ehrlich Ascites Carcinoma* Jerome J. Freed; Jerome J. Freed ... Jerome J. Freed, David A. Hungerford; DNA Content of Nuclei and Chromosome Number in Sublines of the Ehrlich Ascites Carcinoma* ... The distribution of nuclear DNA values in the Lettré-Ehrlich mouse ascites carcinoma, and in some of its hypertetraploid (EL88 ...
Anticancer potential of Michelia champaca Linn. bark against Ehrlich ascites carcinoma (EAC) cells in Swiss albino mice
Furthermore, it was found that bark extract decreased tumor cell proliferation (77.46%; P,0.01), tumor weight (42.13%; P,0.001 ... stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) ... stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) ... tumor weight measurement, and survival time etc. The mechanism of EAC killing was examined by observation of cell morphology ...
TPEN - ALX-450-011 - Enzo Life Sciences
Find Research outputs - Manipal Academy of Higher Education, Manipal, India
Ashwagandha: MedlinePlus suplementos
Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Acta Oncol. 1996;35:95-100. ... on a transplantable mouse tumor, Sarcoma-180. Indian J Exp Biol. 1993;31:607-611. View abstract. ... In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. Cancer Lett. 8-16- ... on a transplantable mouse tumor, Sarcoma 180. Indian J Exp Biol. 1992;30:169-172. View abstract. ...
Subject: antineoplastic agents / Subject term: antineoplastic activity / Text Availability: Citation in PubAg - PubAg Search...
... in combination with low level ionising radiation in female mice with solid tumors from inoculated Ehrlich ascites carcinoma ... 3. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting ... This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma ( ... Tumor cell-inoculated mice received daily extract doses (100 mg/kg, 200 mg/kgBW) with or without a sing .... DOI:. 10.1080/ ...
DeCS
Carcinoma, Ehrlich Tumor Entry term(s). Ascites Tumor, Ehrlich Ehrlich Ascites Tumor Ehrlich Tumor Carcinoma Tumor, Ehrlich ... Ascites Tumor, Ehrlich. Ehrlich Ascites Tumor. Ehrlich Tumor Carcinoma. Tumor, Ehrlich Ascites. ... tumor ascítico de Ehrlich tumor carcinoide de Ehrlich tumor de Ehrlich Scope note:. Tumor trasplantable, maligno, pobremente ... Carcinoma, Ehrlich Tumor - Preferred Concept UI. M0003437. Scope note. A transplantable, poorly differentiated malignant tumor ...
IMSEAR at SEARO: Search
JournalTOCs
Ehrlich ascites carcinoma cells*. Authors: Biswakanth Kar, Pallab K Haldar, Goutam Rath, Goutam Ghosh. Pages: 98 - 103. ... Traditionally, the various parts of the plants have been used in the treatment of wound healing, pain, and tumor. Objective: To ... and bcl2 gene expression in Ehrlich ascites carcinoma (EAC) cells lines and establish the possible mechanisms linked with ...
Merkel Cell Carcinoma and Rare Appendageal Tumors: Overview, Tumors of the Epidermis, Tumorlike Lesions of Fibrous or Elastic...
Cutaneous tumors encompass a vast array of malignancies, from neuroendocrine to lymphoid. In addition to primary malignancies, ... Moyer KE, Banducci DR, Graham WP 3rd, Ehrlich HP. Dupuytrens disease: physiologic changes in nodule and cord fibroblasts ... encoded search term (Merkel Cell Carcinoma and Rare Appendageal Tumors) and Merkel Cell Carcinoma and Rare Appendageal Tumors ... clear cell carcinoma, and mucinous carcinoma. [130] All these tumors have the capacity to metastasize to skin and regional ...
In vitro inhibitory effects of lentinan on rat glioma cells.
... for Ehrlich carcinoma. According lentinan has no direct effect on killing tumor cells in vivo, it can enhance the bodys immune ... of the tumor, as well as the maximum tumor plane in sagittal scan and height (H). According to these indices, the tumor ... Tumor growth of treatment groups. As shown in Figure 1, intracranial tumor in situ was successfully implanted, and conducted ... Immunohistochemical detection of tumor tissues. The rats were killed on the 21th day after treatment. The tumor tissues were ...
Molecular Biology (BMBB) - Research output
- [email protected]
Ehrlich Tumor Carcinoma 66% * Ascites 59% * Growth 30% * Neoplasms 19% 35 Scopus citations ... DNA transfer from Agrobacterium to plant cells in crown gall tumor disease.. Das, A., 1998, In: Sub-cellular biochemistry. 29, ... Antiangiogenic and proapoptotic activities of allyl isothiocyanate inhibit ascites tumor growth in vivo. Kumar, A., DSouza, S ...
Influence of halloysite nanotubes on the efficiency of Asparaginase against mice Ehrlich solid carcinoma. | Saudi J Biol Sci...
It promoted the ASNase to inhibit the adverse effect of ANases on the liver and remove the tumour cells. ... Ehrlich ascites carcinoma; ESC, Ehrlich Solid Carcenoma; HNTs, Halloysite Nanotubes; Halloysite nanotubes, Cancer; ... Influence of halloysite nanotubes on the efficiency of Asparaginase against mice Ehrlich solid carcinoma. ... halloysite nanotubes have demonstrated effective removal of Ehrlich solid carcinoma in mice using an ASNase delivery system. ...
Publications | Laser Dynamics Lab
DeCS 2008 - versión 17 de Marzo de 2008
Purple Lapacho Anti-Cancer
Lapacho have been found to suppress tumor formation and reduce tumor viability. ... Walker carcinosarcoma 256 and Ehrlich solid carcinoma) and Ehrlich ascites cell tumors. Such research then took a gigantic ... including adeno-carcinoma of the liver, breast and prostate and squamous-cell carcinoma of the palate and uterine cervix. Taken ... Some constituents or groups of constituents of lapacho have indeed been found to suppress tumor formation and reduce tumor ...
Search | SciELO
A Comprehensive Review on Food and Medicinal Prospects of Astraeus hygrometricus | FullTxt.Org
on Ehrlichs ascites carcinoma cells. Dig J Nanomater Biostruct. 2012;7(1):185-91 ... It was noted that administration of AE2 to tumour-bearing mice significantly reduced the tumour growth, prolonged their ... Protein A-Activated Macrophages Induce Apoptosis in Ehrlichs Ascites Carcinoma Through a Nitric Oxide-Dependent Pathway. ... activation had an inhibitory effect on various types of cancers including Ehrlichs ascites carcinoma.99,100 This might be an ...
Disease - ca Index | CureHunter Mobile
Carcinoma, Cribriform Carcinoma, Ductal Carcinoma, Ductal, Breast Carcinoma, Ductal, Pancreatic Carcinoma, Ehrlich Tumor ... Carcinoma Carcinoma 256, Walker Carcinoma in Situ Carcinoma of Endocrine Gland Carcinoma of Endometrium Carcinoma, Acinar ... Carcinoma, Small Cell Carcinoma, Small Cell Lung Carcinoma, Spindle Cell Carcinoma, Spindle-Cell Carcinoma, Squamous Carcinoma ... Carcinoma, Islet Cell Carcinoma, Krukenberg Carcinoma, Large Cell Carcinoma, Lewis Lung Carcinoma, Lobular Carcinoma, Male ...
Publications | Laser Dynamics Lab
Publications | Laser Dynamics Lab
A review on anticancer potential of Berberis aristata and berberine with focus on quantitative methods Rokade M, Vichare V,...
evaluate the antineoplastic activity of extracts of BA in ehrlich ascites carcinoma bearing mice using cisplatin as positive ... It was found that ethanolic extract increases the weight due to tumor cell proliferation and also survival time when compared ... Anticancer activity of Berberis aristata in ehrlich ascites carcinoma-bearing mice: A preliminary study. Pharm Biol 2012;50:270 ... The cytotoxicity was carried out using BSL test, the cisplatin and extracts reversed the tumor-induced alteration in total WBCs ...
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells through PI3K/Akt/mTOR signalling pathway. ...
Objective This study aimed to test the hypothesis that levobupivacaine has anti-tumour effects on breast cancer cells Results ... Effect of local anaesthetic ropivacaine on the energy metabolism of Ehrlich ascites tumour cells. Oncol Res, 1998; 10:491e8. ... Lidocaine Induces Apoptosis and Suppresses Tumour Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft ... A study of interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-α) serum levels in rats subjected to faecal peritonitis ...
SquamousAscites carcinoma in miceMiceHepatocellular carcinomaSolid tumorsUpper aerodigestive tractAnti-tumor activityCancerSuppressor genesSuppresses tumorPromoter methylationAnticancerBiomarkersMethylationMalignant tumorBreast carcinomaCellsPrognosisSignificant antitumorBrain tumorCutaneousHNSCCRenalHuman chorionic goExperimentalProgressionHydroxychloroquineTesticularSerumGrowthDescriptorMetastasisPatternsChemotherapyCell cultures
Squamous21
- KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
- [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
- In one clinical study, South American researchers administered lapacho to patients with various forms of cancer, including adeno-carcinoma of the liver, breast and prostate and squamous-cell carcinoma of the palate and uterine cervix. (fasting.ws)
- Patients with advanced inoperable melanoma, cutaneous/head and neck squamous cell or adenoid cystic carcinoma and at least one lesion accessible for IT injection are eligible. (esmo.org)
- Deletion of 8p23.2 or reduced expression of CSMD1 has been associated with poor prognosis in head and neck squamous cell carcinomas and in prostate cancers [2,5,8]. (mindunwindart.com)
- While CSMD1 transcripts are detectable in upper aerodigestive tract epithelium, preliminary analysis of several head and neck squamous cell carcinoma cellular lines recommended that CSMD1 appearance was dropped in these lines [1]. (mindunwindart.com)
- Although the spot that contains CSMD1 is certainly often removed in throat and mind squamous cellular carcinomas and prostatic adenocarcinomas [3,11-15], stage mutations within the gene are fairly rare in principal squamous malignancies [16] and in squamous cellular carcinoma cellular lines (Schmidt, Scholnick and Richter, unpublished). (mindunwindart.com)
- Within this paper, we demonstrate that some squamous cellular carcinoma cellular lines usually do not exhibit full duration CSMD1 transcripts, all produce unusual transcripts improbable to encode useful CSMD1 proteins almost. (mindunwindart.com)
- Used jointly these data show that mechanisms apart from stage mutation are 89464-63-1 in charge of the aberrant CSMD1 appearance in mind and throat squamous cell carcinoma cell lines, and these data suggest potential targets for further investigation in main tumors. (mindunwindart.com)
- Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. (uchicago.edu)
- In this patient, who had a T4N2cM0 squamous cell carcinoma of the oropharynx, an apron flap was elevated that extended from 1 mastoid tip to the other. (medscape.com)
- Actinic keratoses may remain unchanged, spontaneously resolve, or progress to invasive squamous cell carcinoma. (medscape.com)
- Additionally, actinic keratoses can be clinically indistinguishable from more serious cutaneous malignancies, including squamous cell carcinoma and lentigo maligna. (medscape.com)
- Lesions may progress into invasive squamous cell carcinomas. (medscape.com)
- Epidemiology of actinic keratoses and squamous cell carcinoma. (medscape.com)
- Inflammation is associated with progression of actinic keratoses to squamous cell carcinomas in humans. (medscape.com)
- Prognosis of patients with advanced head and neck squamous cell carcinomas (HNSCC) is still poor. (iozk.de)
- Characterization of Epigenomic Alterations in HPV16+ Head and Neck Squamous Cell Carcinomas. (cdc.gov)
- The expression and methylation of PITX genes is associated with the prognosis of head and neck squamous cell carcinoma. (cdc.gov)
- Differentially methylated genes in proliferative verrucous leukoplakia reveal potential malignant biomarkers for oral squamous cell carcinoma. (cdc.gov)
- Clinical performance validation of PITX2 DNA methylation as prognostic biomarker in patients with head and neck squamous cell carcinoma. (cdc.gov)
Ascites carcinoma in mice2
- A novel kefir product (PFT) inhibits Ehrlich ascites carcinoma in mice via induction of apoptosis and immunomodulation. (greenmedinfo.com)
- Egyptian propolis contains a higher level of flavonoids, phenolics, and dihydroflavonoids in propolis extract, and it has anticancer effects in vitro studies and inhibits tumor development in Ehrlich ascites carcinoma in mice model. (totokr.com)
Mice17
- IMSEAR at SEARO: Evaluation of anti-tumor efficacy of injectable Centchroman in mice bearing Ehrlich ascites carcinoma. (who.int)
- Anti-tumor efficacy of Centchroman formulated as niosomes and gel implant was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma at 10 mg/kg body weight dose given subcutaneously. (who.int)
- Anticancer and apoptogenic effect of graviola and low-dose radiation in tumor xenograft in mice. (greenmedinfo.com)
- In vivo testing of 400 mg/kg OT or dehydroepiandrosterone-sulfate in C57BL/6 mice hosting Ehrlich's ascitic tumor cells revealed a 90.4 and a 46% decrease in the final tumor mass after 3 days of treatment. (nih.gov)
- In tumour-bearing mice, WSF inhibited the expression of pStat-3, with a selective stimulation of Th1 immunity as evidenced by enhanced secretion of IFN-gamma and IL-2. (mcw.edu)
- In addition, WSF also enhanced T cell activation in camptothecin treated tumour-bearing mice. (mcw.edu)
- The aim of the present study was to characterize the Ehrlich tumor as a model of lymphatic metastasis in mice. (usp.br)
- Methods: In vivo anticancer activity was evaluated against EAC cells bearing Swiss albino mice by monitoring parameters such as tumor cell proliferation, tumor weight measurement, and survival time etc. (edu.au)
- M. champaca bark also altered the depleted hematological parameters such as red blood cell, white blood cell, hemoglobin (Hb%) towards normal in tumor bearing mice. (edu.au)
- Influence of halloysite nanotubes on the efficiency of Asparaginase against mice Ehrlich solid carcinoma. (bvsalud.org)
- In conclusion, halloysite nanotubes have demonstrated effective removal of Ehrlich solid carcinoma in mice using an ASNase delivery system. (bvsalud.org)
- When TNF-α levels w ere measured in mice bearing the S-180 carcinoma, mice treated with TCM-EF showed slightly higher TNF-α levels as compared to the control group. (skku.edu)
- The antitumor effect of an organic germanium compound, carboxyethylgermanium sesquioxide (Ge-132), was examined in mice using two systems: one, the ascitic form of Ehrlich carcinoma in DDI mice, and the other, the solid form of Meth-A fibrosarcoma in BALB/c mice. (greenmedinfo.com)
- In the mice with Ehrlich ascitic tumors, a remarkable prolongation in life span was observed after intraperitoneal (i.p.) or per oral (p.o.) administration of Ge-132 (300 mg/kg), but not after intravenous (i.v.) injection of the same compound. (greenmedinfo.com)
- When the in vivo effect of these in vitro active Mø was examined after adoptive transfer to mice bearing Ehrlich ascitic tumor cells, a significant antitumor effect was noted. (greenmedinfo.com)
- In the mice bearing solid Meth-A tumors, i.v. injections of Ge-132 (100 mg/kg) were found to inhibit tumor growth remarkably, although i.p. and p.o. administrations did not have the same result. (greenmedinfo.com)
- When the mice which had recovered from Meth-A tumor growth, following i.v. injections of Ge-132, were challenged with the same tumor on day 30, all mice were able to tolerate the challenge, but nota challenge of RL male 1 tumor cells. (greenmedinfo.com)
Hepatocellular carcinoma2
- Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. (usda.gov)
- hepatitis viruses B and C are associated with hepatocellular carcinoma (Monto and Wright 2001 ), Simian virus 40 has been linked to mesothelioma (Rizzo et al. (biomedcentral.com)
Solid tumors2
- Animal research in the United States made a gigantic stride forward when it was discovered that lapacho inhibited solid tumors (Walker carcinosarcoma 256 and Ehrlich solid carcinoma) and Ehrlich ascites cell tumors. (fasting.ws)
- This phase I study is evaluating IT injection of CV8102 alone or in combination with a systemic anti-PD-1 antibody in patients with advanced solid tumors. (esmo.org)
Upper aerodigestive tract1
- History CUB and Sushi Multiple Domains 1 ( CSMD1 ) was cloned as an applicant tumor suppressor or development gene from an area of individual chromosome 8 deleted in tumors of the upper aerodigestive tract, prostate, ovary and bladder [1-7]. (mindunwindart.com)
Anti-tumor activity4
- According lentinan has no direct effect on killing tumor cells in vivo, it can enhance the body's immune function to display anti-tumor activity [ 8 ]. (alliedacademies.org)
- In the lactic acid bacteria in the gut, we directed our attention to TCM-EF, which have been known as using the bacteria death of lactic acid bacteria by heat treatment, and examined the mechanisms by which these substances affect antioxidant activity, anti-tumor activity and immunoresponse. (skku.edu)
- Thus, TCM-EF showed strong anti-tumor activity against two kinds of solid carcinoma. (skku.edu)
- In a syngeneic murine model, intratumoral (IT) delivery of CV8102 induced dose-dependent anti-tumor activity and synergized with systemic anti-PD1 antibody treatment. (esmo.org)
Cancer10
- Demonstration of the ability to self-renew, a key feature of stem cells, is achieved through serial passage of tumors in xenohosts, and the impact of cancer stem cells on the practice of medicine is likely to be profound. (semanticscholar.org)
- The capacity of single embryonal carcinoma cells to differentiate into benign tissues supports neither the dogma of the irreversibility of the malignant transformation nor the somatic cell mutation theory of cancer. (semanticscholar.org)
- Lung cancer is one of the most common types of malignant tumor. (usda.gov)
- Lentinan has a strong inhibitory effect on cancer cells, with inhibition rates of 97.5% for mouse sarcoma 180 and 80% for Ehrlich carcinoma . (alliedacademies.org)
- The present study aimed to investigate the anti-tumour effects of levobupivacaine on breast cancer cells. (researchsquare.com)
- Fisher, Fisher: 'Host-tumor relationship in the development and growth of hepatic metastases' In: Wissler, Dao, Wood: 'Endogenous Factors Influencing Host-Tumor Balance, International Symposium Sponsored by the Argonne Cancer Research Hospital, University of Chicago 149-166 1966 University of Chicago Press 1967 Bild von 5000 Tumorzellen und Faktoren die Wachstum beschleunigen und Wachstum hemmen. (50g.com)
- Local activation of innate immune signaling pathways, such as Toll-like Receptors (TLRs) or RIG-I-like Receptors (RLRs), is a promising cancer immunotherapeutic approach to overcome the tumor immunosuppressive microenvironment and to induce/restore anti-tumor immunity. (esmo.org)
- We hypothesize that hyperglycemia provides a nutrient-rich, growth signal-rich environment for epithelial ovarian cancer cells, where tumour formation and growth is encouraged by free radical-induced DNA damage. (hindawi.com)
- Retine, or alpha-ketoaldehyde, inhibits the growth of certain types of cancer, including sarcoma 180 and Ehrlich carcinoma. (mycoldiscovery.com)
- 1999) found agglutinin cytotoxic or inhibit tumor cells in LS174T, SW1222 and HT human colon cancer cells. (mycoldiscovery.com)
Suppressor genes2
- Tumor suppressor genes are expected to be inactivated in cancers either genetically by mutations or epigenetically by modification of their promoters. (mindunwindart.com)
- Activation of oncogenes or silencing of tumor suppressor genes may be the result of long lasting inflammation. (biomedcentral.com)
Suppresses tumor1
- Taken altogether, this strongly suggests that TCM-EF enhances original functions of macrophages and NK cells, and as a result, secondarily enhances the immune reaction and suppresses tumor growth. (skku.edu)
Promoter methylation2
- Thus, gene promoter methylation induced by JCV may be an important process in CRC and the polyp-carcinoma sequence. (biomedcentral.com)
- Significance of PITX2 Promoter Methylation in Colorectal Carcinoma Prognosis. (cdc.gov)
Anticancer2
- Anticancer effects of combination of indole-3-carbinol and hydroxychloroquine on ehrlich ascites carcinoma. (greenmedinfo.com)
- Therefore, enzymes or substrates regulating the nonoxidative synthesis of ribose could also be the sites to preferentially target tumor cell proliferation by new anticancer drugs. (nih.gov)
Biomarkers2
- The primary objective is to determine safety and tolerability, secondary/explorative objectives are to evaluate tumor response and changes in tumor tissue and blood-based biomarkers. (esmo.org)
- Fig. 1: Developmental biology as a driver for uncovering testicular germ cell tumour biomarkers. (nature.com)
Methylation1
- The association of CRC hMLH1 methylation and tumor positivity for JCV was recently documented. (biomedcentral.com)
Malignant tumor1
- A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. (bvsalud.org)
Breast carcinoma3
- The IC 50 values showed that this effect was more intense on breast normal cells (MCF-10A) than on breast carcinoma cells (MCF-7 and 4T1). (biomedcentral.com)
- The treatment with rhodium (II) citrate-loaded maghemite nanoparticles and magnetoliposomes induced more specific cytotoxicity on breast carcinoma cells than on breast normal cells, which is the opposite of the results observed with free Rh 2 (H 2 cit) 4 treatment. (biomedcentral.com)
- Breast carcinoma represents the major cause of death among women worldwide. (biomedcentral.com)
Cells16
- Cytological investigations based on morphological and statisticzl analysis of the chromosomes in several ascites tumors of rats conducted by the present author in collaboratioii with his co-workers have revealed tlie existence of the stem line (or stem lines) of tumor cells as primary contributors to the growth of the tumor. (semanticscholar.org)
- It would appear that the progeny of malignant stem cells can differentiate into postmitotic benign cells incapable of forming a tumor. (semanticscholar.org)
- Deregulated apoptosis and suppressed tumour reactive immunity render tumour cells to grow amok in the host body. (mcw.edu)
- Animals were inoculated into the footpad and the popliteal lywph nodes were collected at several times post-inoculation in order to evaluate their weight, histopathological aspects,and mast cells quantitation, since these cells are reported to be implicated in host's response to tumor. (usp.br)
- The migration of tumor cells was detected by a biological assay as early as 1 hour post-inoculation. (usp.br)
- Objective: In the present study, stem-bark of Mycelia champaca is subjected to evaluate its anti-proliferative effect against Ehrlich ascites carcinoma (EAC) cells. (edu.au)
- Group 1 ( control ), Group 2 (ESC group) of a single dose of 0.15 ml Ehrlich cells (2 × 106) intraperitoneal infusion (IP), Group 3 (ESC + ANase group) received six doses equal treatments of Intratumoral (IT) 0.07 ml Aspragnase (7 mg/kg) over two weeks. (bvsalud.org)
- It promoted the ASNase to inhibit the adverse effect of ANase's on the liver and remove the tumour cells . (bvsalud.org)
- Superparamagnetic particles of iron oxide (SPIOs) represent an attractive platform as carriers in drug delivery systems (DDS) because they can present greater specificity to tumor cells than normal cells. (biomedcentral.com)
- Thus, magnetic nanoparticles represent an attractive platform as carriers in Rh 2 (H 2 cit) 4 delivery systems, since they can act preferentially in tumor cells. (biomedcentral.com)
- Ursolic acid having anti-mutagenic nature has the potential to induce apoptosis in tumor cells as well as to prevent malignant transformation of normal cells [ 12 ]. (genominfo.org)
- Urine cytology showed malignant cells strongly suspicious for adenocarcinoma which correlated with the biopsy findings where immunohistochemistry demonstrated carcinoma with glandular differentiation and positivity for cytokeratin (CK) 20, fully compatible with a metastatic colonic type adenocarcinoma. (docksci.com)
- It is their activity, how well they recognize and find tumor cells, that is most important. (mycoldiscovery.com)
- Vaccine was prepared from the tumor cell cultures of patients by infection of the cells with Newcastle Disease Virus, followed by gamma-irradiation, and vaccine was applied up to five times. (iozk.de)
- Immune monitoring revealed significant increases of antitumor delayed type hypersensitivity reactivity especially in disease-free patients, and in a significant proportion of vaccinated patients the presence of tumor-reactive T-cells in the peripheral blood even 5 to 7 years after the last vaccination. (iozk.de)
- Postoperative vaccination with virus-modified autologous tumor cells seems to be feasible and safe and may improve the prognosis of HNSCC patients with advanced tumors. (iozk.de)
Prognosis1
- Glioma is the most common primary brain tumor, but the treatment is troublesome and the prognosis is poor due to invasive growth [ 4 ]. (alliedacademies.org)
Significant antitumor1
- Rhodium (II) citrate (Rh 2 (H 2 cit) 4 ) has significant antitumor, cytotoxic, and cytostatic activity on Ehrlich ascite tumor. (biomedcentral.com)
Brain tumor1
- Predicting neurocognitive function in pediatric brain tumor early survivorship: The neurological predictor scale and the incremental validity of tumor size. (mdanderson.org)
Cutaneous3
- Cutaneous tumors encompass a vast array of malignancies, ranging from neuroendocrine to lymphoid in origin. (medscape.com)
- The diagnosis and treatment of these cutaneous tumors is constantly evolving, and the role of clinicians relies on accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
- The origin of cutaneous tumors can be simplistically divided into three major categories: epidermal, dermal, and adnexal (see image below). (medscape.com)
HNSCC1
- Therefore, we analyzed whether antitumor vaccination with a virus-modified autologous tumor cell vaccine is feasible and safe in HNSCC patients. (iozk.de)
Renal2
- Progression of two of the three transplantable Morris renal tumors: study of histology, ultrastructure and chromosome banding patterns. (semanticscholar.org)
- He has been a member of the Children's Oncology Group Renal Committee for the past decade and has reviewed the radiotherapy fields and doses in children with Wilms' tumors treated in the previously opened Renal studies. (mdanderson.org)
Human chorionic go1
- For decades, clinical management of patients with TGCT has relied on classic serum tumour markers: α-fetoprotein, human chorionic gonadotropin subunit-β and lactate dehydrogenase. (nature.com)
Experimental2
- These findings are discussed in regard to the experimental use of ascites tumor populations. (aacrjournals.org)
- Some constituents or groups of constituents of lapacho have indeed been found to suppress tumor formation and reduce tumor viability, both in experimental animal trials and in clinical settings involving human patients. (fasting.ws)
Progression3
- A yellow Himalayan raspberry extract was effective in wound healing and reduction of tumor progression. (greenmedinfo.com)
- Resveratrol is a polyphenol isolated from the grapes skin, shown to alter both cell cycle progression and the cytotoxic response to ionizing radiation in cervical tumor cell lines [ 13 ]. (genominfo.org)
- If hyperglycemia contributes to tumour growth and progression, then it is intuitive that antihyperglycemic drugs may also have an important antitumour role. (hindawi.com)
Hydroxychloroquine1
- This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. (usda.gov)
Testicular1
- A basis is established for the occurrence of multiple types of testicular tumor in one testis and for the histogenesis of the various germinal tumors of the testicle. (semanticscholar.org)
Serum2
- In the past 10 years, microRNAs have been shown to outperform classic serum tumour markers in the diagnosis of primary tumours and in follow-up monitoring and prediction of relapse. (nature.com)
- Fig. 2: Sensitivity of the classic serum tumour markers AFP, β-HCG and LDH in detecting TGCT compared with miRNA-based markers (all miRNA tests considered). (nature.com)
Growth5
- This study investigates the significance of the glucose-6-phosphate dehydrogenase (G6PD) catalyzed oxidative and the transketolase (TK) catalyzed nonoxidative pentose cycle (PC) reactions in the tumor proliferation process by characterizing tumor growth patterns and synthesis of the RNA ribose moiety in the presence of respective inhibitors of G6PD and TK. (nih.gov)
- WSF at 150mg/kg, i.p., inhibited >50% tumour growth in the mouse tumour models. (mcw.edu)
- The solid tumor growth in the footpad was measured until day 30 post-inoculation and the histological alterations during this period were also studied. (usp.br)
- Our understanding of the interrelationship between nutrition, immunology, oncogenesis, and tumor growth is steadily increasing. (caninebiologics.com)
- The combined action of the LiCl(I)-I2-a-dextrin-peptide complex drug and doxorubicin on the growth of Ehrlich ascites carcinoma (EAC) has been shown to significantly enhance doxorubicin's antitumor function. (2pressrelease.net)
Descriptor1
- Tumor Virus Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Metastasis2
- Ehrlich tumor was considered as a suitable model for the study of lymphatic metastasis. (usp.br)
- The differential diagnosis of ureteral adenocarcinoma, especially in patients with previous history of colon adenocarcinoma, should include the possibility of distant metastasis from the primary colonic tumor. (docksci.com)
Patterns1
- In the Lettré-Ehrlich strain, the patterns of DNA distribution in the population and of chromosome number were constant and of the type expected from the work of others and from theoretical considerations. (aacrjournals.org)
Chemotherapy1
- Outcomes based on histopathologic response to preoperative chemotherapy in children with bilateral Wilms tumor: A prospective study (COG AREN0534). (mdanderson.org)
Cell cultures2
- In this work, we report the cytotoxicity of free rhodium (II) citrate (Rh 2 (H 2 cit) 4 ) and rhodium (II) citrate-loaded maghemite nanoparticles or magnetoliposomes, used as drug delivery systems, on both normal and carcinoma breast cell cultures. (biomedcentral.com)
- Establishment of tumor cell cultures was successful in about 80% of the cases. (iozk.de)