Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Breast Neoplasms: Tumors or cancer of the human BREAST.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Breast Diseases: Pathological processes of the BREAST.Cell Line, Tumor: A cell line derived from cultured tumor cells.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Metallothionein: A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Liver Neoplasms: Tumors or cancer of the LIVER.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Breast Feeding: The nursing of an infant at the breast.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Mammography: Radiographic examination of the breast.Fibrocystic Breast Disease: A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.Breast Neoplasms, Male: Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Nipples: The conic organs which usually give outlet to milk from the mammary glands.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Mastectomy: Surgical procedure to remove one or both breasts.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Lung Neoplasms: Tumors or cancer of the LUNG.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Tamoxifen: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)DNA, Neoplasm: DNA present in neoplastic tissue.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mastectomy, Segmental: Removal of only enough breast tissue to ensure that the margins of the resected surgical specimen are free of tumor.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Fibroadenoma: An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Breast Self-Examination: The inspection of one's breasts, usually for signs of disease, especially neoplastic disease.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Mammary Glands, Human: Glandular tissue in the BREAST of human that is under the influence of hormones such as ESTROGENS; PROGESTINS; and PROLACTIN. In WOMEN, after PARTURITION, the mammary glands secrete milk (MILK, HUMAN) for the nourishment of the young.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Mammary Glands, Animal: MAMMARY GLANDS in the non-human MAMMALS.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Ultrasonography, Mammary: Use of ultrasound for imaging the breast. The most frequent application is the diagnosis of neoplasms of the female breast.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Colonic Neoplasms: Tumors or cancer of the COLON.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Genes, BRCA1: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Antineoplastic Agents, Hormonal: Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Carcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Mouth Neoplasms: Tumors or cancer of the MOUTH.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.RNA, Neoplasm: RNA present in neoplastic tissue.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Skin Neoplasms: Tumors or cancer of the SKIN.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Genes, erbB-2: The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.Stomach Neoplasms: Tumors or cancer of the STOMACH.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)Transplantation, Heterologous: Transplantation between animals of different species.Estrogen Receptor alpha: One of the ESTROGEN RECEPTORS that has marked affinity for ESTRADIOL. Its expression and function differs from, and in some ways opposes, ESTROGEN RECEPTOR BETA.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Axilla: Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Postmenopause: The physiological period following the MENOPAUSE, the permanent cessation of the menstrual life.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Mammaplasty: Surgical reconstruction of the breast including both augmentation and reduction.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Salivary Ducts: Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Mastectomy, Modified Radical: Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Adenofibroma: A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Genes, BRCA2: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human chromosome 13 at locus 13q12.3. Mutations in this gene predispose humans to breast and ovarian cancer. It encodes a large, nuclear protein that is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev 2000;14(11):1400-6)Apocrine Glands: Large, branched, specialized sweat glands that empty into the upper portion of a HAIR FOLLICLE instead of directly onto the SKIN.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Keratin-5: A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.Ductus Arteriosus: A fetal blood vessel connecting the pulmonary artery with the descending aorta.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Menopause: The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.Keratin-6: A type II keratin found associated with KERATIN-16 or KERATIN-17 in rapidly proliferating squamous epithelial tissue. Mutations in gene for keratin-6A and keratin-6B have been associated with PACHYONYCHIA CONGENITA, TYPE 1 and PACHYONYCHIA CONGENITA, TYPE 2 respectively.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)BRCA2 Protein: A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6)Premenopause: The period before MENOPAUSE. In premenopausal women, the climacteric transition from full sexual maturity to cessation of ovarian cycle takes place between the age of late thirty and early fifty.Breast Cyst: A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.BRCA1 Protein: The phosphoprotein encoded by the BRCA1 gene (GENE, BRCA1). In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (Science 1995;270(5237):713,789-91)Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.MCF-7 Cells: An estrogen responsive cell line derived from a patient with metastatic human breast ADENOCARCINOMA (at the Michigan Cancer Foundation.)Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Neoplasms, Hormone-Dependent: Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.Milk, HumanNeoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Therapeutic Irrigation: The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Mice, Inbred BALB C
Characterization of human MMTV-like (HML) elements similar to a sequence that was highly expressed in a human breast cancer: further definition of the HML-6 group. (1/2323)Previously, we found a retroviral sequence, HML-6.2BC1, to be expressed at high levels in a multifocal ductal breast cancer from a 41-year-old woman who also developed ovarian carcinoma. The sequence of a human genomic clone (HML-6.28) selected by high-stringency hybridization with HML-6.2BC1 is reported here. It was 99% identical to HML-6.2BC1 and gave the same restriction fragments as total DNA. HML-6.28 is a 4.7-kb provirus with a 5'LTR, truncated in RT. Data from two similar genomic clones and sequences found in GenBank are also reported. Overlaps between them gave a rather complete picture of the HML-6.2BC1-like human endogenous retroviral elements. Work with somatic cell hybrids and FISH localized HML-6.28 to chromosome 6, band p21, close to the MHC region. The causal role of HML-6.28 in breast cancer remains unclear. Nevertheless, the ca. 20 Myr old HML-6 sequences enabled the definition of common and unique features of type A, B, and D (ABD) retroviruses. In Gag, HML-6 has no intervening sequences between matrix and capsid proteins, unlike extant exogenous ABD viruses, possibly an ancestral feature. Alignment of the dUTPase showed it to be present in all ABD viruses, but gave a phylogenetic tree different from trees made from other ABD genes, indicating a distinct phylogeny of dUTPase. A conserved 24-mer sequence in the amino terminus of some ABD envelope genes suggested a conserved function. (+info)
Spectral morphometric characterization of breast carcinoma cells. (2/2323)The spectral morphometric characteristics of standard haematoxylin and eosin breast carcinoma specimens were evaluated by light microscopy combined with a spectral imaging system. Light intensity at each wavelength in the range of 450-800 nm was recorded for 10(4) pixels from each field and represented as transmitted light spectra. A library of six characteristic spectra served to scan the cells and reconstruct new images depicting the nuclear area occupied by each spectrum. Fifteen cases of infiltrating ductal carcinoma and six cases of lobular carcinoma were examined; nine of the infiltrating ductal carcinoma and three of the lobular carcinoma showed an in situ component. The spectral morphometric analysis revealed a correlation between specific patterns of spectra and different groups of breast carcinoma cells. The most consistent result was that lobular carcinoma cells of in situ and infiltrating components from all patients showed a similar spectral pattern, whereas ductal carcinoma cells displayed spectral variety. Comparison of the in situ and the infiltrating ductal solid, cribriform and comedo carcinoma cells from the same patient revealed a strong similarity of the spectral elements and their relative distribution in the nucleus. The spectrum designated as number 5 in the library incorporated more than 40% of the nuclear area in 74.08% of the infiltrating lobular cells and in 13.64% of the infiltrating ductal carcinoma cells (P < 0.001). Spectrum number 2 appeared in all infiltrating ductal cells examined and in none of the lobular cells. These results indicate that spectrum number 5 is related to infiltrating lobular carcinoma, whereas spectrum number 2 is characteristic for infiltrating ductal carcinoma cells. Spectral similarity mapping of central necrotic regions of comedo type in situ carcinoma revealed nuclear fragmentation into defined segments composed of highly condensed chromatin. We conclude that the spectral morphometric features found for lobular and ductal cell populations may serve future automated histological diagnostics. (+info)
Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. (3/2323)We have previously reported that loss of p53 tumor suppressor protein results in centrosome hyperamplification, which leads to aberrant mitosis and chromosome instability. Since p53 is either deleted or mutated in human cancers at a high frequency, we investigated whether human cancers showed centrosome hyperamplification. Screening of advanced stage breast ductal carcinomas and squamous cell carcinomas of the head and neck (SCCHN) revealed that centrosome hyperamplification is frequent in both tumor types. Moreover, through the analyses of p53 in SCCHN samples by direct sequencing and by loss-of-heterozygosity test, we found that p53 mutations correlated with occurrence of centrosome hyperamplification. However, in some cases, we observed centrosome hyperamplification in tumors that retained wild-type p53. These tumors contained high levels of Mdm2. Since Mdm2 can inactivate p53 through physical association, we investigated whether Mdm2 overexpression induced centrosome hyperamplification. We found that Mdm2 overexpression, like loss of p53, induced centrosome hyperamplification and chromosome instability in cultured cells. (+info)
Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. (4/2323)CD40 is present on B cells, monocytes, dendritic cells, and endothelial cells, as well as a variety of neoplastic cell types, including carcinomas. CD40 stimulation by an antibody has previously been demonstrated to induce activation-induced cell death in aggressive histology human B-cell lymphoma cell lines. Therefore, we wanted to assess the effects of a recombinant soluble human CD40 ligand (srhCD40L) on human breast carcinoma cell lines. Human breast carcinoma cell lines were examined for CD40 expression by flow cytometry. CD40 expression could be detected on several human breast cancer cell lines and this could be augmented with interferon-gamma. The cell lines were then incubated with a srhCD40L to assess effects on in vitro growth. srhCD40L significantly inhibited the proliferation of the CD40(+) human breast cancer cell lines. This inhibition could also be augmented with interferon-gamma. Viability was also affected and this was shown to be due to increased apoptosis of the cell lines in response to the ligand. Treatment of tumor-bearing mice was then performed to assess the in vivo efficacy of the ligand. Treatment of tumor-bearing SCID mice with the ligand resulted in significant increases in survival. Thus, CD40 stimulation by its ligand directly inhibits human breast carcinoma cells in vitro and in vivo. These results suggest that srhCD40L may be of clinical use to inhibit human breast carcinoma growth. (+info)
Induction of mammary carcinomas by N-methyl-N-nitrosourea in ovariectomized rats treated with epidermal growth factor. (5/2323)The importance of epidermal growth factor (EGF) in both normal and malignant mammary gland development are presented in these studies. Initial findings demonstrated that in the absence of ovarian hormones, EGF had a significant proliferative effect on mammary epithelial cells. To determine whether mammary epithelial cells grown with EGF, in the absence of ovarian hormones, could be transformed by N-methyl-N-nitrosourea (MNU), female ovariectomized Lewis rats were implanted with pellets containing EGF for 1 week and then treated with MNU for initiation. Two days after MNU treatment, ovaries were implanted and EGF pellets were removed from all ovariectomized groups in order to promote carcinogenesis. The mammary carcinoma incidence of the EGF-stimulated group (90%) was not significantly different from the intact group (100%). The mammary cancer morphology of EGF-treated carcinomas was either ductal carcinoma or cribriform adenocarcinoma, whereas intact animals developed mainly papillary and occasional cribriform carcinomas. Fifty-eight percent of the carcinomas from the EGF group were ovarian hormone-independent compared with 10% of carcinomas from the intact group. These results demonstrate that EGF-induced proliferation during initiation with MNU was sufficient to induce the transformation of mammary carcinomas in the absence of ovarian hormones. The hormonal dependency of these EGF-induced carcinomas were different compared with MNU-initiated mammary carcinomas in intact rats. (+info)
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. (6/2323)A centrosomal serine/threonine kinase, AIK1(3)/breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells. Benign breast lesions including fibrocystic disease and fibroadenoma (epithelial components) displayed weakly detectable AIK1 expression in part of the lesions. This is the first immunohistochemical report of AIK1 expression in primary human breast carcinomas. Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells. (+info)
The influence of margin width on local control of ductal carcinoma in situ of the breast. (7/2323)BACKGROUND: Ductal carcinoma in situ is a non-invasive carcinoma that is unlikely to recur if completely excised. Margin width, the distance between the boundary of the lesion and the edge of the excised specimen, may be an important determinant of local recurrence. METHODS: Margin widths, determined by direct measurement or ocular micrometry, and standardized evaluation of the tumor for nuclear grade, comedonecrosis, and size were performed on 469 specimens of ductal carcinoma in situ from patients who had been treated with breast-conserving surgery with or without postoperative radiation therapy, according to the choice of the patient or her physician. We analyzed the results in relation to margin width and whether the patient received postoperative radiation therapy. RESULTS: The mean (+/-SE) estimated probability of recurrence at eight years was 0.04+/-0.02 among 133 patients whose excised lesions had margin widths of 10 mm or more in every direction. Among these patients there was no benefit from postoperative radiation therapy. There was also no statistically significant benefit from postoperative radiation therapy among patients with margin widths of 1 to <10 mm. In contrast, there was a statistically significant benefit from radiation among patients in whom margin widths were less than 1 mm. CONCLUSIONS: Postoperative radiation therapy did not lower the recurrence rate among patients with ductal carcinoma in situ that was excised with margins of 10 mm or more. Patients in whom the margin width is less than 1 mm can benefit from postoperative radiation therapy. (+info)
Prospective sonographic study of 3093 breast tumors. (8/2323)To evaluate the predictive ability of sonographic tumor characteristics to differentiate benign from malignant tumors, we examined 3093 breast tumors (2360 benign and 733 malignant tumors) with ultrasonography. The ratio of the longest dimension to the anteroposterior diameter of benign tumors was significantly larger than that of malignant tumors (1.88+/-0.1 versus 1.69+/-0.02, P < 0.0001). Shape, margins, echogenicity, internal echo pattern, retrotumor acoustic shadowing, compressibility, and microcalcification were significant factors in the logistic regression model. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of breast sonography for malignancy were 86.1, 66.1, 44.1, 93.9, and 70.8%, respectively. Biopsy of the tumor for pathologic diagnosis is recommended if sonographic features are suggestive of malignancy. (+info)
There is accumulating evidence to suggest that different histological grades of invasive ductal breast carcinomas may have distinct molecular origins and pathogenesis and do not typically progress from one grade group to another (28, 29, 30, 31) . The different grades have different clinical behaviors, and within-grade studies to identify the more aggressive subgroups of these classes of breast tumors would be of great assistance in clinical management. The expression of basal/myoepithelial markers has been observed in a proportion of grade III invasive breast tumors, and the spectrum of basal-like tumors, also recognized by morphology (15 , 32) , molecular cytogenetics (16 , 33) , and expression profiling (18 , 19) , has been associated with poor prognosis (17) . CGH has the advantage of being applied to archival pathology specimens with long-term follow-up as well as being amenable to microdissection strategies to profile the molecular genetic change occurring in a pure population of tumor ...
Gentaur molecular products has all kinds of products like :search , US Biomax \ Breast invasive ductal carcinoma tissue array with matched adjacent normal breast tissue, including TNM and pathology grade, 6 cases_24 cores, replacing BR243 \ BR243a for more molecular products just contact us
Gentaur molecular products has all kinds of products like :search , US Biomax \ Breast invasive ductal carcinoma with matched or unmatched adjacent normal breast tissue array, including TNM and pathology grade, 47cases_80cores, replacing BR802 \ BR802b for more molecular products just contact us
Jin, R.,Bay, B.H.,Chow, V.T.K.,Tan, P.H.,Lin, V.C.L. (2000). Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer. British Journal of Cancer 83 (3) : 319-323. [email protected] Repository ...
Mas pin is a se rine p rotease inhibito r with tumo r-su p p resso r activity. Mas pin can su p p ress tumo r g rowth and metastasis in vivo and tumo r cell motility and invasion in vit ro. P revious
PURPOSE: Information on tubular carcinoma (TC) of breast is limited due to its rarity. A multi-institutional study was performed to investigate the prognosis and failure patterns of TC compared to invasive ductal carcinoma (IDC). MATERIALS AND METHODS: We collected retrospective data on 205 patients with TC from eleven institutions. For each TC case, 3 cases with IDC were matched according to similar size, t-stage, and n-stage from the same institution. Patterns of failure, disease free survival (DFS) and overall survival (OS) were assessed and compared between the groups. RESULTS: DFS at 5 years was 98.8% and 97.3% and OS at 5 years was 99.5% and 99.6% in TC and IDC, respectively. Among the patients with TC, 5 patients (2.4%) developed contralateral breast cancer, while 3 patients (0.5%) presented with contralateral breast cancer in patients with IDC. CONCLUSIONS: The TC of breast presents an excellent prognosis, but the contralateral breast cancer tends to be more frequently observed compared ...
Mai, K. T., Perkins, D. G. and Mirsky, D. (2003), Location and Extent of Positive Resection Margins and Ductal Carcinoma in Situ in Lumpectomy Specimens of Ductal Breast Carcinoma Examined with a Microscopic Three-Dimensional View. The Breast Journal, 9: 33-38. doi: 10.1046/j.1524-4741.2003.09108.x ...
New research from Amsterdam shows that women over the age of 50 who have been diagnosed with ductal carcinoma in situ have a higher chance of being alive ten years after their diagnosis than women in the general population, according to Science Daily. Ductal carcinoma in situ is considered a disease separate from breast cancer because it is at stage 0 and does not spread around the body. However, ductal carcinoma in situ can progress into full-blown breast cancer, which is why it is still treated with surgery or surgery in combination with radiation therapy.. The researcher Dr. Lotte Elshof presented findings at the European Cancer Congress 2017. Women who have been diagnosed with ductal carcinoma in situ should feel better about their future because of these findings, which show their longevity will not be impacted by this condition.. Dr. Jelle Wesseling and her team at the Netherlands Cancer Institute followed approximately 10,000 Dutch women with ductal carcinoma in situ between the years ...
Invasive ductal carcinoma (IDC) is the most common form of breast cancer. Find out about IDC symptoms, diagnosis and treatment at Breast Cancer Care.
approximately three-quarters of breast cancers Invasive ductal carcinoma - 55% of breast cancers Ductal carcinoma in situ - 13% Invasive lobular carcinoma - 5% The overall 5-year survival rate for both ... Ductal carcinoma in situ, on the other hand, is in itself harmless, although if untreated approximately 60% of these low grade DCIS lesions will become invasive over the course of 40 years in follow-up ...
Invasive ductal carcinoma is the most commonly diagnosed breast cancer and has a tendency to metastasize via lymphatics. This lesion, which accounts for 75% of breast cancers, has no specific histolog... more
Background: Mounting evidence indicates that tumor-specific host immunity is associated with favorable prognosis in a variety of cancer settings. However, the role of immunity in breast cancer remains controversial. The purpose of this study was to determine the significance of tumor infiltrating leukocytes (TIL) with respect to pathological features and patient survival in estrogen receptor alpha (ER) negative breast cancer.. Patients and Methods: Tissue microarrays and immunohistochemistry were used to assess and categorize TIL in a cohort of 255 ER-negative invasive ductal breast carcinomas. Cases were registered by the Manitoba Breast Tumor Bank during the years 1988 to 2000 and had a minimum follow-up of 36 months. Stromal and intraepithelial TIL expressing the markers CD3, CD8, CD4, TIA1, CD25, FOXP3, CD20, CD68, and myeloperoxidase (MPO) were quantified by an experienced pathologist (PHW) and evaluated for associations with pathological parameters and survival. The median value for each ...
Hello, I was recently diagnozed with Invasive Ductal Carcinoma. I am 26 years old and this was such a shock to me and my husband. There are really no support groups in my area and I would love to hear from anyone going through this. ------------------------------------------------------------------------ This is an automatically-generated notice. If youd like to be removed from the mailing list, please visit the Medicine-On-Line Discussion Forum at ,http://www.meds.com/con_faq.html,, or send an email message to: [email protected] with the subject line blank and the body of the message containing the line: unsubscribe mol-cancer your-email-address where the phrase your-email-address is replaced with your actual email address ...
Purpose: The present study analyzed the polymorphisms of DNA repair genes and their impact on survival of patients with early breast cancer.Patients and methods: A total of 240 patients with surgically resected early invasive ductal breast cancer were enrolled in the present study, where patients who underwent neoadjuvant treatment were excluded. The genomic DNA was extracted from paraffin-embedded tumor-free tissue or blood, and thirteen single nucleotide polymorphisms of 12 DNA repair genes were determined using the Sequenom Mass array system.Results: Among the target SNPs, VARS2 rs2074511 and POLE rs5744857 were found to correlate with relapse-free survival (RFS) after curative surgery in the log-rank test. There was no difference in the clinical and tumor characteristics according to the genotypes of these two coding variants except for the higher incidence of positive ER in patients with the GG genotype of POLE rs5744857 (p = 0.025). Multivariate analysis showed that the GG genotype of ...
Invasive ductal carcinoma is the most common type of breast malignancy, with varying molecular features and resistance to treatment. Although CD44+/CD24- cells are believed to act as breast cancer stem cells and to be linked to poor prognosis in some patients, the association between these cells and tumor recurrence or metastasis in all or some types of invasive ductal carcinoma is unclear. A total of 147 randomly selected primary and secondary invasive ductal carcinoma samples were assayed for expression of CD44, CD24, ER, PR, and Her2. The association between the proportions of CD44+/CD24- tumor cells and the clinico-pathological features of these patients was evaluated. CD44+/CD24- tumor cells were detected in 70.1% of the tumors, with a median proportion of 5.8%. The proportion of CD44+/CD24- tumor cells was significantly associated with lymph node involvement (P = 0.026) and PR status (P = 0.038), and was correlated with strong PR status in patients with recurrent or metastatic tumors (P = 0.046)
Symptoms, diagnosis, treatment and prognosis for invasive ductal carcinoma-from the Johns Hopkins Breast Center in Baltimore, MD. Also get info for medullary, mucinous, papillary and tubular ductal carcinomas.
Recent studies suggest an association between chronic inflammation, modulating the tissue microenvironment, and tumor biology. Tumor environment consists of tumor, stromal and endothelial cells and infiltrating macrophages, T lymphocytes, and dendritic cells, producing an array of cytokines, chemokines and growth factors, accounting for a complex cell interaction and regulation of differentiation, activation, function and survival of tumor and surrounding cells, responsible for tumor progression and spreading or induction of antitumor immune responses and rejection. Tumor Necrosis Factor (TNF) family members (19 ligands and 29 receptors) represent a pleiotropic family of agents, related to a plethora of cellular events from proliferation and differentiation to apoptosis and tumor reduction. Among these members, BAFF and APRIL (CD257 and CD256 respectively) gained an increased interest, in view of their role in cell protection, differentiation and growth, in a number of lymphocyte, epithelial and
Hollie Quinn suffered from the typical health complaints of an adult female; these included heartburn and acid reflux, along with painful cysts, vertigo and migraines.. Hollie says that she ate the typically American diet which was low in vegetables, high in sugar, and drank soda daily. She never questioned the health directives given to her by her doctors, and was never told that there might be a connection between her health issues and the diet that she was eating.. In 2002, when Hollie was just 27 years old and in her 38th week of pregnancy, she was diagnosed with an infiltrating ductal carcinoma. This is the most common type of breast cancer which affects some 80% of patients, and as its name suggests, the cancer had broken through the milk duct and was invading the surrounding tissues of the breast. Over time, invasive ductal carcinomas can spread to the lymph nodes and to other areas of the body. Hollies main tumor was 2.3 cm, with a second tumor measuring 0.6 cm. The larger tumor was a ...
In conclusion, Dr. Lori Pierce, Vice Provost for Academic and Faculty Affairs and Professor of Radiation Oncology at the University of Michigan, says "this article has summarized nicely the major challenges facing breast cancer patients and their physicians in the management of ductal carcinoma in situ (DCIS). DCIS is not an invasive disease but can progress to invasive breast cancer, and potentially impact survival, in a significant number of women if not adequately treated when diagnosed. And we know that for those patients treated with lumpectomy, radiation to follow will reduce the chance of DCIS returning and/or invasive disease developing by at least 50%. We also know, however, that in some patients, the likelihood that DCIS will progress to invasive disease is very low even in the absence of treatment. Unfortunately, we have not found a reproducible way to predict those who need to be treated and those who dont but many researchers are working on this very question. For now, clinicians ...
(KudoZ) English to Spanish translation of Metastatic Ductal Carcinoma of the Breast: carcinoma ductal metastásico de mama [Medical (general) (Medical)].
The most common type of invasive breast cancer. It begins in the lining of the milk ducts (thin tubes that carry milk from the lobules of the breast to the nipple) and spreads outside the ducts to surrounding normal tissue.
To compare the lesion distribution and the extent of the disease in ductal and lobular carcinomas of the breast, we studied 586 ductal and 133 lobular consecutive cancers. All cases were documented on large-format histology slides. The invasive component of ductal carcinomas was unifocal in 63.3% (371/586), multifocal in 35.5% (208/586), and diffuse in 1.2% (7/586) of the cases. The corresponding figures in the lobular group were 27.8% (37/133), 45.9% (61/586), and 26.3% (35/133), respectively. When the distribution of the in situ and invasive component in the same tumors was combined to give an aggregate pattern, the ductal carcinomas were unifocal in 41.6% (244/586), multifocal in 31.6% (185/586), and diffuse in 26.8% (157/586) of the cases. The corresponding figures in the lobular category were 15.0% (20/133), 54.2% (72/133), and 30.8% (41/133), respectively. Ductal cancers were extensive in 45.7% (268/586), lobular in 65.4% (87/133) of the cases. All these differences were statistically ...
The distribution of ductal carcinoma in situ DCIS grade in 4232 women and its impact on overdiagnosis in breast cancer screening. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
On July 23, 2008, I was diagnosed with bilateral breast cancer, invasive ductal carcinoma, Stage II, and ductal carcinoma in situ, Stage O. This blog was started to keep my family and friends connected during my surgery and treatment. This is my story!. ...
On July 23, 2008, I was diagnosed with bilateral breast cancer, invasive ductal carcinoma, Stage II, and ductal carcinoma in situ, Stage O. This blog was started to keep my family and friends connected during my surgery and treatment. This is my story!. ...
Mammography screening is deemed cost-effective for women aged 50-70. Yet the utilities informing breast screening policy are limited in their ability to adequately capture the benefits and risks. The evaluation of many cancer screening programmes present results in terms of cost per QALY but fail to include any disutility for the patients who have been over-diagnosed and may receive unnecessary treatment. This thesis presents an overview of the challenges associated with valuing breast cancer states, using the results of an empirical study deriving utilities from 172 women in Melbourne, Australia as an example of potential methods to capture the disutility of overtreatment. Ductal carcinoma in situ was used as a proxy to quantify the benefits and harms associated with the sequelae of screening. Utilities derived from 172 women for health states explicitly describing overdiagnosis were lower than those from the literature, where it is unlikely that women were informed that their treatment may ...
Queenie - Patient: Breast Cancer > Ductal carcinoma in situ (DCIS) Patient Info: Currently in active treatment (initial surgery, receiving chemo rounds/radiation), Diagnosed: over 7 years ago, Female, Age: 74, Stage I
copland16 - Survivor: Breast Cancer > Ductal carcinoma in situ (DCIS) Patient Info: Finished active treatment less than 5 years ago, Diagnosed: over 9 years ago, Female, Age: 48, Stage II, HER2 Positive: No, ER Positive: Yes, PR Positive: Yes
Rita - Patient: Breast Cancer > Ductal carcinoma in situ (DCIS) Patient Info: Currently in active treatment (initial surgery, receiving chemo rounds/radiation), Diagnosed: almost 7 years ago, Female, Age: 50, Stage 0
penny364 - Survivor: Breast Cancer > Ductal carcinoma in situ (DCIS) Patient Info: Finished active treatment less than 5 years ago, Diagnosed: about 5 years ago, Female, Age: 71, Stage 0, HER2 Positive: No, ER Positive: Yes, PR Positive: Yes
fortysomething - Survivor: Breast Cancer > Ductal carcinoma in situ (DCIS) Patient Info: Finished active treatment less than 5 years ago, Diagnosed: over 11 years ago, Female, Age: 50
Patient: Breast Cancer > Invasive (Infiltrating) Ductal Carcinoma Patient Info: Living with cancer as a chronic illness (undergoing adjuvant therapy), Diagnosed: almost 16 years ago, Female, Age: 53, Stage III, HER2 Positive: Yes, ER Positive: No, PR Positive: No
MarcieB - Patient: Breast Cancer > Invasive (Infiltrating) Ductal Carcinoma Patient Info: Currently in active treatment (initial surgery, receiving chemo rounds/radiation), Diagnosed: over 1 year ago, Female, Age: 72, Stage II, HER2 Positive: Yes, ER Positive: Yes, PR Positive: Yes
Survivor: Breast Cancer > Invasive (Infiltrating) Ductal Carcinoma Patient Info: Finished active treatment less than 5 years ago, Diagnosed: almost 4 years ago, Female, Age: 47, Stage III, HER2 Positive: No, ER Positive: Yes, PR Positive: Yes
Dr. Ansanellis laser surgery serves as a tremendous benefit to a Ductal Carcinoma In Situ patient as it greatly reduces the chance of cancer cell spread.
Introduction Ductal carcinoma in situ (DCIS) is a common pre-invasive malignancy of the breast, representing approximately 20% of all breast cancer diagnoses...
HCC1395 BL is a B lymphoblastoid cell line initiated by Epstein-Barr virus (EBV) transformation of peripheral blood lymphocytes obtained from the same patient as the breast carcinoma cell line HCC1395. The cell line was initiated from a 43-year-old white female with a TNM stage I, grade 3 primary ductal carcinoma and a prior history of cancer; her mother had breast cancer.
RATIONALE: Diagnostic procedures, such as MRI, may help find ductal carcinoma in situ and find out how far the disease has spread.PURPOSE: This
Zamecnik, M. Atypical cystic lobules: an advancing edge of low-grade ductal carcinoma in situ?. Virchows Archiv 437, 469 (2000). https://doi.org/10.1007/s004280000253. Download ...
I recently was diagnosed with breast cancer...invasive ductal carcinoma. Absolutely no history of this in my family. Could there be a link between all the drugs for ms Ive taken and that?? Ive seen some posts on cop axons and ...
classification and prognostic scoring along with quantification of immune cells/mm  was performed. Data were entered and analyzed using SPSS version 16. Correlation of immune cell densities with various tumour sub-types was investigated using paired t-test and ANOVA. A p-value of ...
This is a case-based activity that includes discussion of a 36-year-old woman who originally presented at 18 weeks gestation with clinical T2N0, grade 3 invasive ductal carcinoma of the right breast. The tumor was ER+, PR+, and HER2 negative ...
When I was diagnosed with Invasive Ductal Carcinoma in 2015, I wanted my experience to have a purpose. I later celebrated my survivorship with a glamorous photo shoot, and felt other survivors could benefit from its psychological healing. PWCG helps patients wrap their heads around breast cancer, navigating them through treatment, side effects, and a "new normal". We celebrate survivorship, aiming to provide FREE glamorous photo shoots for up to 13 survivors a year. Your business with PWCG helps fund our mission. ...
荊 雪楓 , 覚道 健一 , 村上 真紀 , 中村 靖司 , 中村 美砂 , 横井 豊治 , 尾浦 正二 , 桜井 武男 ホルモンと臨牀 46, 157-166, 1998-09-30 医中誌Web 参考文献23件 ...
Established in 1995 from a primary ductal infiltrating breast carcinoma of a 50-year-old Caucasian woman; cells are described to be estrogen- and progesterone-receptor negative, and to possess a point mutation in p53 and a five-fold amplification of ...
Tie2/Tek expression in breast carcinoma: correlations of immunohistochemical assays and long-term follow-up in a series of 909 patients.: The degree of angiogen
Learning, knowledge, research, insight: welcome to the world of UBC Library, the second-largest academic research library in Canada.
Ductal carcinoma in situ is the fourth most common cancer diagnosis in women. Some say its not "really" cancer. But you wouldnt know that based on how it is treated.. by Sue Rochman ...
Epiteliul simplu pavimentos scuamos este alctuit din celule turtite papilar al dermului, n hipoderm, n corionul mucoaselor, n jurul organelor mobile dup hipertrofia i hiperplazia organului,in lunile la bovine si ecvine,cand splina.
Squamous cell carcinoma of the breast and its subtype, basal-human epidermal growth factor receptor 2 (HER2) phenotype, are very rare. Herein, we report a patient who developed recurrence of squamous cell carcinoma of the breast with basal-HER2 subtype 6 years after the initial diagnosis of invasive ductal carcinoma of the HER2 subtype. To the best of our knowledge, recurrence of invasive ductal carcinoma in the form of metaplastic squamous cell carcinoma of basal-HER2 subtype has not been reported previously. We present a pathological perspective of our experience ...
ConferenceSeries organizes Invasive Ductal Carcinoma national symposiums, conferences across the globe in association with popular Invasive Ductal Carcinoma associations and companies. OMICS group planned its conferences, and events in america, europe, middle east and asia pacific. locations which are popular with international conferences, symposiums and events are china, canada, dubai, uae, france, spain, india, australia, italy, germany, singapore, malaysia, brazil, south korea, san francisco, las vegas, san antonio, omaha, orlando, raleigh, santa clara, chicago, philadelphia, baltimore, united kingdom, valencia, dubai, beijing, hyderabad, bengaluru and mumbai
Gene expression profiling has taught us a great deal about the progression of fully-developed invasive breast cancer, and our study used this approach as a starting point to learn more about the progression of DCIS to invasive breast cancer. We are aware of at least 9 previous studies comparing expression between DCIS and invasive breast cancer, publishing results that can be compared with ours (8-16, 30). Collectively, these studies included 130 cases of DCIS and 126 of invasive breast cancer, which pales in comparison to previous expression profiling studies of invasive breast cancer alone involving thousands of cases. Our study increases the number of samples comparing DCIS to invasive breast cancer by about 50%, which is a helpful contribution given the relatively small numbers of cases overall addressing this important question.. A proportion of samples from this (17%) and the previous (37%) studies were paired DCIS and invasive breast cancer from the same breasts, which may not be the ...
AIMS--To determine if allelic loss on chromosomes 16q and 17p, commonly encountered in in situ and invasive ductal carcinomas, is present in atypical ductal hyperplasia (ADH); to determine whether ADH is a neoplastic (clonal) or hyperplastic (polyclonal) proliferation. METHODS--Fourteen cases of ADH were examined for allele loss at loci on chromosome 16q and 17p using a microdissection technique, polymorphic DNA markers and the polymerase chain reaction (PCR). RESULTS--Loss of heterozygosity (LOH) was detected in five of nine informative cases on chromosome 16q at the microsatellite D16S413 and two of eight informative cases on chromosome 17p at D17S796. CONCLUSIONS--The incidence of LOH at these loci is similar to that previously observed in ductal carcinoma in situ and in invasive ductal carcinoma. Because of the nature of the technique used, our findings also demonstrate that ADH is a monoclonal, and hence, neoplastic proliferation rather than a hyperplastic (polyclonal) condition as its name ...
Invasive lobular carcinoma (ILC), sometimes called infiltrating lobular carcinoma, is the second most common type of breast cancer after invasive ductal carcinoma. About 10% of all invasive breast cancers are invasive lobular carcinomas. Learn about the diagnosis and treatment of invasive lobular carcinoma.
Breastfeeding and Immunohistochemical Expression of ki-67, p53 and BCL2 in Infiltrating Lobular Breast Carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Abstract: Background and Objectives: The initiating steps and precise pathway of breast tumorigenesis are poorly understood and it is unclear if Ductal Carcinoma In Situ (DCIS) progresses to invasive ductal carcinoma (IDCA) of the breast. This study was undertaken to identify proteins that are differentially expressed between IDCA and DCIS and that may predict the invasive potential of breast tumors. Methodology: It is utilized that the two-dimensional difference in gel electrophoresis technology (2D-DIGE) and tandem mass spectrometry (LC-MS/MS) to perform proteomic analysis of IDCA (MCF-7 and BT-474) and DCIS (HCC-1500 and HCC-38) cell lines. Results: Identified 10 proteins that were differentially expressed between IDCA and DCIS (≥2-fold difference; p≤0.05) and classified the proteins according to their Gene Ontology (GO). Out of these proteins, 60 kDa mitochondrial heat shock protein (HSPD1), Heat Shock Protein Beta 1 (HSPB1) and the voltage-dependent anion-selective channel protein 1 ...
Conducted in the three-county Seattle-Puget Sound metropolitan area, the population-based study included women ages 55 to 74 years: 880 of the women had invasive ductal breast cancer, 1,027 had invasive lobular breast cancer, and 856 of them had no cancer and served as the control group. Interviewing participants in person, researchers gathered in-depth histories of hypertension and heart disease, as well as risk factors for cancer, including family history, obesity, smoking, and alcohol use. Through a series of structured questions, the research also included detailed data regarding use of antihypertensive drugs, such as beginning and end dates of use, drug names, dose, route of administration, pattern of use, and indication ...
PHILADELPHIA - A recent report in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, adds to the growing evidence that fish oil supplements may play a role in preventing chronic disease. Researchers at the Fred Hutchinson Cancer Research Center in Seattle, Wash., led by Emily White, Ph.D., a member of the public health sciences division, asked 35,016 postmenopausal women who did not have a history of breast cancer to complete a 24-page questionnaire about their use of non-vitamin, non-mineral "specialty" supplements in the Vitamins and Lifestyle (VITAL) cohort study. After six years of follow-up, 880 cases of breast cancer were identified using the Surveillance, Epidemiology and End Results registry. Regular use of fish oil supplements, which contain high levels of the omega-3 fatty acids, EPA and DHA, was linked with a 32 percent reduced risk of breast cancer. The reduction in risk appeared to be restricted to invasive ductal breast cancer, ...
The Y-box-binding protein 1 (YB-1), a member of the cold-shock domain RNA-and DNA-binding protein family, has pleiotropic functions such as regulation of the cell cycle. The aim of this study was to evaluate if YB-1 is a proliferative marker in breast cancer and elucidate potential downstream targets involved in YB-1-mediated cell cycle regulation using RNA interference technology. YB-1 protein expression was evaluated in tissue microarrays of 131 breast invasive ductal carcinomas by immunohistochemistry, while the YB-1 gene expression profile was evaluated in the T-47D, MDA-MB-231, ZR-75-1 and MCF7 breast cancer cell lines. Silencing of the YB-1 gene in T-47D breast cancer cells was performed using siRNA and the effects of down-regulation of YB-1 on cell growth and regulation of the cell cycle were ascertained. A focused panel of 84 genes involved in cell cycle progression was also examined. In tissue microarrays, YB-1 expression was shown to be associated with proliferating cell nuclear ...
Ductal carcinoma in situ is a noninvasive precancer condition. The treatment resembles the treatment of invasive breast cancer. The aim of this exploratory study was to gain knowledge on the level of postoperative pain, sensory disturbances, and distress among a small group of Danish women with ductal carcinoma in situ who had sentinel lymph node biopsy in order to plan a population study. A subgroup of patients with ductal carcinoma in situ (n = 20) was compared to patients with invasive breast cancer (n = 455) at time of diagnosis and after 12 months. Six patients were interviewed on the impact of the diagnosis and life after treatment. We found no significant difference in reported sensory disturbances or pain after 12 months between the groups. More than one-third (39%) of ductal carcinoma in situ patients reported moderate to severe distress (≥ 7 on the Distress Thermometer) at time of diagnosis decreasing to 10% after 12 months. Similarly 36% of breast cancer patients reported distress ...
BACKGROUND: To investigate markers for predicting breast cancer progression, we performed a candidate gene-based study that assessed expression change of three genes, cyclin D1, β-catenin, and metastasis-associated protein-1 (MTA1), involving in aggressive phenotypes of cancerous cells, namely hyperproliferation, epithelial-mesenchymal transition, and global transcriptional regulation.. METHODS: Specimens were from 150 enrolled female patients, with invasive ductal carcinoma, followed up for more than 10 years. mRNA expression of cyclin D1, β-catenin, and MTA1 in cancerous and noncancerous cells microdissected from the primary tumor site was determined by quantitative real-time PCR. The relationship between mRNA expression levels of the genes and clinicopathologic features was assessed by statistical analysis. Disease-free and overall survival (DFS and OS) were analyzed by Kaplan-Meier analysis with log-rank test and a multivariate Cox regression model.. RESULTS: Cyclin D1 was shown to be ...
Lobular breast cancer, or invasive lobular carcinoma, starts out in the lobules, the glands that produce milk. Learn about symptoms, treatments, and more.
Sirolimus in Preventing Invasive Breast Cancer in Patients with Ductal Carcinoma In Situ, Lobular Carcinoma In Situ, Atypical Lobular Hyperplasia, or Atypical Ductal Hyperplasia - NCT02642094
Abstract Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells that is separated from the breast stroma by an intact layer of basement membrane and myoepithelial cells. DCIS is a non-obligate precursor of invasive breast cancer, and up to 40% of these lesions progress to invasive disease if untreated. Currently, it is not possible to predict accurately which DCIS would be more likely to progress to invasive breast cancer as neither the significant drivers of the invasive transition have been identified, nor has the clinical utility of tests predicting the likelihood of progression been demonstrated. Although molecular studies have shown that qualitatively, synchronous DCIS and invasive breast cancers are remarkably similar, there is burgeoning evidence to demonstrate that intra-tumor genetic heterogeneity is observed in a subset of DCIS, and that the process of progression to invasive disease may constitute an evolutionary bottleneck, resulting in the ...
Aimée was diagnosed with Stage 2B/3A Invasive Ductal Breast Cancer. She was selected as a pro-bono candidate for proton therapy and had a very successful run with it, totaling six weeks. She recently graduated on April 13, and received her medal of honor in the form of a "challenge coin" engraved with her patient number, 891. The coin signifies her fight against cancer, so she can put this chapter of her life behind her ...
When a pathologist examines the tissue under a microscope, he or she looks for small clusters of tumor cells that appear to "float" in pools of mucin. The tumor may be made up mostly of mucin, or mostly of cancer cells separated by small amounts of mucin.. Mucinous carcinoma also can be found near, or mixed in with, other more common types of breast cancer. Sometimes a ductal carcinoma in situ (or DCIS, a cancer that has not spread outside the milk duct) is found near the mucinous carcinoma. A mucinous carcinoma also may have some areas within it that contain invasive ductal carcinoma cells. If the invasive ductal carcinoma cells make up more than 10% of the tumor, the cancer would be called a "mixed" mucinous carcinoma. A "pure" mucinous carcinoma means that at least 90-100% of the cells are mucinous.. Now or after surgery, the tissue should be tested for some other important features of a pure mucinous breast carcinoma:. ...
Our study found that a history of a clinical diagnosis of migraine is associated with a 26% reduced risk of breast cancer among both premenopausal and postmenopausal women. This result is consistent with the 33% reduction in risk of invasive ductal breast carcinomas observed in the only other published study to assess this relationship (1). In the data presented here, the association between migraine and breast cancer did not vary substantially by age at migraine diagnosis, but there was some suggestion that risks were lower among women who had used prescription migraine medications. Although we did not assess migraine severity, use of prescription medications may be a proxy for more severe disease, or this observation could also reflect a reduction in risk associated with use of these medications. The lack of a significant effect among women not using medication may also be the result of exposure misclassification because the proportion of women reporting a history of migraine who actually only ...
OS is a malignant tumor that occurs in bone tissues and mainly affects adolescents (16). Through developments in diagnostic and therapeutic techniques, the 5-year survival rate of patients with OS has increased by 60-70% in the last decade; however, the 20-year survival rate of patients with OS remains low, at ~20% (17,18). The mechanisms involved in the development of OS are largely unclear; thus, the identification of novel biomarkers in OS may be useful for future diagnosis and treatment of patients.. Dysregulated C-type lectins have been found in various diseases, including cancer (19,20). CLEC-2, a member of the C-type lectin family, was highly expressed in clear cell renal cell carcinoma and was positively associated with poor patient prognosis (21) and it was also observed to regulate cell proliferation and migration (22). CLEC3A, another C-type lectin, was reported to be highly expressed in breast invasive ductal carcinoma and promoted breast cancer cell proliferation and migration (8). ...
This is the first comprehensive study of MUC5AC immunoexpression in breast cancer. We detected MUC5AC expression in five of 68 cases, which included one pure colloid carcinoma (out of three cases) and four invasive ductal carcinomas (out of 65 cases). In a previous study, OConnell et al showed an altered pattern of mucin expression in mucinous (colloid) breast carcinomas.13 Using in situ hybridisation, these authors13 showed an increase of MUC2 and MUC5AC expression and a decrease of MUC1 expression in colloid breast carcinomas in comparison with non-colloid breast carcinomas. In the study of OConnell et al,13 MUC1 and MUC2 expression was studied by immunocytochemistry and in situ hybridisation, whereas the expression of MUC5AC was evaluated by in situ hybridisation alone. Our results reinforce their observations, showing that MUC5AC is overexpressed in some cases of colloid breast carcinoma. However, at variance with these authors13 we found that MUC5AC expression is not restricted to colloid ...
It is generally believed that atypical ductal hyperplasia (ADH) is a direct precursor of breast cancer and therefore portends breast cancer in the same breast, while atypical lobular hyperplasia (ALH) has an equal risk of cancer in both breasts and may not be a direct precursor of breast cancer. In the study, however, published in Cancer Prevention Research (2014;7;211-217) and led by Lynn C. Hartmann, MD, Professor of Oncology, cancer was twice as likely to occur in the breast having the biopsy, and this was true for both ADH and ALH.. Moreover, the findings run counter to current understanding that ALH primarily leads to lobular cancer. Instead, the researchers discovered that ALH was associated predominantly with later ductal cancers of the breast-also similar to cancers after ADH.. Both types resulted in invasive ductal cancers, and 69 percent were of intermediate or high grade. Further, about 25 percent had spread to the lymph nodes. Although the numbers were not statistically significant, ...
E-cadherin local dynamics were studied in mature junctions, that is, junctions engaged in adhesion for many hours, in which cadherin expression level ...
This multicentre retrospective study is characterised by a long period of accrual (median follow-up: 136 months,; range: 16-292 months), which offers the advantage of providing interesting information about the trend of the disease. A certain number of patients (12 patients) enrolled in the first years have died during this long period of observation; other patients (47 patients) didnt return for the planned examination to the Centre of Radiotherapy where they had been treated, and were lost to follow-up. In addition only approximately 20% of patients were treated in the first period (from 1985 to 1990) and the number of cases increased progressively during the following years (Figure 1). Most of the cases belong to the two decades covered by the screening activity. Nevertheless, a large number of cases were also found in the younger age group, between 41 and 50. Increased debate and publicity about breast cancer screening after the introduction of screening programmes could have determined an ...
Description of disease Breast, infiltrating lobular carcinoma of the. Treatment Breast, infiltrating lobular carcinoma of the. Symptoms and causes Breast, infiltrating lobular carcinoma of the Prophylaxis Breast, infiltrating lobular carcinoma of the
Hi. I did a search for Ductal Carcinoma and one of the hits was a letter from Jayna. I dont see anything else. Is there a web site I can go to? I would really like to find a lot more information about surgery, therapy and all alternatives. I know I am at the beginning of a long hard journey but I would like to give a little background which may help you point me in the right direction. I am 31 years old and back in August I found a lump. I spoke to my sister and a friend about it and both said wait a week or two to see if it would go away. I was a week away from my period so I waited. It did not go away. I called the OB/GYN and got an appointment for October 12th. I did not tell them about the lump, I guess I still figured it would go away. After I made the appointment I spoke to my mother, a breast cancer survivor twice. I told her the position of the lump and we both agreed that it was strange and would probably be nothing. Let me explain. My mother had breast cancer on the left side 11 years ...
Invasive lobular carcinoma has a much lower incidence than infiltrating ductal carcinoma, constituting less than 15% of cases of invasive breast cancer. It is characterized histologically by the &ldqu... more
The widespread adoption of screening mammography has led to an increase in the diagnosis of ductal carcinoma in situ (DCIS) of the breast. While it is estimated that 55,000 women in the US will be diagnosed with DCIS in 2013, only a small fraction of these women (~15%) will subsequently develop invasive breast cancer. However, most women with DCIS are treated as if they will develop invasive cancer. Almost a third of these women opt for a full mastectomy. In a majority of remaining women, the DCIS lesion is surgically excised with lumpectomy and, in over half of these women, additional radiation or tamoxifen treatment is provided. Thus, many women are receiving unnecessary adjuvant therapy to prevent invasive cancers that will not occur. Additionally, ~ 15% of women are not receiving adequate intervention because they will subsequently develop a subsequent invasive tumor even after receiving lumpectomy and adjuvant therapy. Identifying molecular markers that can accurately predict subsequent ...
TY - JOUR. T1 - A Validated Nomogram to Predict Upstaging of Ductal Carcinoma in Situ to Invasive Disease. AU - Jakub, James W. AU - Murphy, Brittany L.. AU - Gonzalez, Alexandra B.. AU - Conners, Amy L.. AU - Henrichsen, Tara L.. AU - Maimone, Santo IV. AU - Keeney, Michael G.. AU - McLaughlin, Sarah A.. AU - Pockaj, Barbara A. AU - Chen, Beiyun. AU - Musonza, Tashinga. AU - Harmsen, William S.. AU - Boughey, Judy C. AU - Hieken, Tina J. AU - Habermann, Elizabeth B. AU - Shah, Harsh N.. AU - Degnim, Amy C. PY - 2017/8/1. Y1 - 2017/8/1. N2 - Background: Approximately 8-56% of patients with a core needle biopsy (CNB) diagnosis of ductal carcinoma in situ (DCIS) will be upstaged to invasive disease at the time of excision. Patients with invasive disease are recommended to undergo axillary nodal staging, most often requiring a second operation. We developed and validated a nomogram to preoperatively predict percentage of risk for upstaging to invasive cancer. Methods: We reviewed 834 cases of DCIS ...
Objective: This study investigated whether gene expression levels of key modulators of the oxysterol signalling pathway modify the prognosis of patients with oestrogen receptor-positive (ER+) breast carcinomas via interaction with endocrine therapy. Context: The prognosis of patients with ER+ breast carcinoma depends on several factors. Previous studies have suggested that some oxygenated forms of cholesterol (oxysterols) bind to oestrogen receptor and anti-oestrogen binding site which may deregulate cholesterol homoeostasis and influence effect of therapy. Design: The expression levels of 70 oxysterol pathway genes were evaluated in a test set of breast carcinomas differing in ER expression. The genes differentially expressed in ER+ tumours were assessed in a comprehensive set of ER+ tumours to evaluate their clinical significance. Patients: A total of 193 primary patients with breast carcinoma were included. Measurements: The transcript levels were determined by quantitative real-time ...
Find the best invasive breast cancer doctors in Bangalore. Get guidance from medical experts to select invasive breast cancer specialist in Bangalore from trusted hospitals - credihealth.com
FRIDAY, Oct. 25, 2019 (HealthDay News) - For each month of delay between diagnosis and surgery for ductal carcinoma in situ (DCIS), there is slightly worse survival and an increase in risk for invasive disease, according to a study published online Sept. 27 in the Annals of Surgical Oncology.. William H. Ward, M.D., from Naval Medical Center in Portsmouth, Virginia, and colleagues used the National Cancer Database to identify women with a clinical diagnosis of DCIS between 2004 and 2014. Differences in overall survival (OS) and presence of invasion were compared for five intervals between diagnosis and surgery (≤30, 31 to 60, 61 to 90, 91 to 120, and 121 to 365 days).. The researchers identified 140,615 clinical DCIS patients, of whom 123,947 had pathologic diagnosis of DCIS and 16,668 had invasive ductal carcinoma. Overall, five-year OS was 95.8 percent, and unadjusted median delay from diagnosis to surgery was 38 days. There was a 7.4 percent increased relative risk for death for each ...
At Moffitt Cancer Center, breast cancer research is one of our primary areas of focus. Not only are we looking to determine how ductal carcinoma in situ develops, but also how it can be treated more effectively. For instance, we are studying various hormonal therapies and how they affect hormone receptor-positive cancers, using our laboratory advances to improve outcomes and quality of life for each of our patients.. Our expert oncologists can further explain the causes of ductal carcinoma in situ. To make an appointment, call 1-888-663-3488 or submit a new patient registration form online. No referral is required.. Helpful Links:. ...
After having a lumpectomy, chemo and radiation my wife is 2 1/2 years out from treatment and has a recurrence. She is scheduled for a mastectomy. What type of follow up treatment is availible? Her 1...
Ductal carcinoma in situ (DCIS) is a pre-invasive, early form of breast cancer. Find more about how DCIS is diagnosed and treated at Breast Cancer Now.
Initially diagnosed June 4, 2009 Invasive Ductal Carcinoma Stage II,Grade II tumor size: 2-3 cm node positive ER/PR postive HER2 Neu - negative Current Diagnosis: Metastatic Invasive Ductal Carcinoma Grade 3 Mets: Scalp/skin, Liver, Spine, Bone ER/PR + HER2/NEU ...
Background: Carcinoma of breast has become the major public health problem among females in developing as well as developed countries. InNepal it comprises 6% of total cancers cases and often diagnosed at advanced stage. Surgical removal or modified radical mastectomy (MRM) is the most commonly used tools for disease management. The objective of this study is to identify the clinical, macroscopic and microscopic features of MRM specimens.. Materials and methods: This prospective cross-sectional study was carried out at Department of Pathology, Bhaktapur Cancer Hospital, Bhaktapur, Nepal. Macroscopic and microscopic examination provided the tumor size, stage, grade, lymph node status, lympho-vascular invasion and perineural invasion. Data were collected and analyzed using SPSS 16.. Results: The study comprised 112 breast cancer patients of which 109 (97.3%) were females and 3 (2.7%) were males. Invasive ductal carcinoma no specific type was the most common type of breast carcinoma. (84 cases) ...
Breast cancer affects a large number of females in the Western world, accounting for half a million deaths worldwide on an annual basis. Carcinoma of the breast is a heterogeneous disease based on pathological criteria, which is probably due to the multiplicity of genetic lesions that have accumulated during tumor development, resulting in distinct tumor types. The most frequently observed subtypes, invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC), are very distinct phenotypically as well as biochemically (Coradini et al., 2002; Korkola et al., 2003; Mathieu et al., 2004; Zhao et al., 2004; Stange et al., 2006). ILC is a subtype of breast cancer that accounts for 10-15% of all cases and has a greater tendency for multifocal development and bilateral presentation than other primary breast tumors (Newstead et al., 1992; Krecke and Gisvold, 1993; Helvie et al., 1993). Classical ILC is characterized by non-cohesive invasive cells that are arranged in trabecules without mass ...
Get natural cures for Invasive Lobular Carcinoma that can make a difference in your life or the life of someone you love with alternative treatments.
Jones, C., Nonni, A. V., Fulford, L., Merrett, S., Chaggar, R., Eusebi, V., Lakhani, S. R. (2001) CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. BRITISH JOURNAL OF CANCER, 85 (3). pp. 422-427. ISSN 0007-0920 ...
ryan417 - Patient: Breast Cancer > Invasive (Infiltrating) Ductal Carcinoma Patient Info: Newly diagnosed (has not begun treatment), Diagnosed: over 7 years ago, Female, Age: 65, Stage I, HER2 Positive: Yes, ER Positive: Yes, PR Positive: Dont Know
Characteristics of lobular carcinoma and LCIS. Pictures showing the difference, and mentioning possible symptoms, mammogram findings and treatment.
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. As the cancer progresses, signs and symptoms can include a lump or thickening in or near the breast; a change in the size or shape of the breast; nipple discharge, tenderness, or retraction (turning inward); and skin irritation, dimpling, or scaliness. However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a person definitely has ...
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both women and men, the most common form of breast cancer begins in cells lining the milk ducts (ductal cancer). In women, cancer can also develop in the glands that produce milk (lobular cancer). Most men have little or no lobular tissue, so lobular cancer in men is very rare.In its early stages, breast cancer usually does not cause pain and may exhibit no noticeable symptoms. As the cancer progresses, signs and symptoms can include a lump or thickening in or near the breast; a change in the size or shape of the breast; nipple discharge, tenderness, or retraction (turning inward); and skin irritation, dimpling, or scaliness. However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a person definitely has ...
Ductal carcinoma in situ (DCIS) occurs when some of the cells that line a group of milk ducts within your breast have started to become cancer cells.
Secretory breast carcinoma (SBC) is a very rare subtype of breast carcinoma that reported mostly in young women, with a median age of 25 years. Despite the low frequency, SBC elicits pathologic interest because of their unique morphology and excellent prognosis. Authors report a 23-year-old woman presented with a nodule in retro areolar region of her right breast. Microbiopsic examination revealed neoplastic tissue. Pathological examination of tumor revealed SBC. This tumor is morphologically characterized by the presence of abundant eosinophilic secretions in intracellular vacuoles and intercellular spaces. The objective of this paper is to review the epidemiological, clinical, paraclinical and therapeutic aspects of SBC from a case report and literature review.
Cutaneous adnexal tumour showing features of eccrine ductal differentiation that are characterized by a prominent squamoid component.. The tumours usually presents as solitary dermal nodules on the head and neck areas and the extremities in elderly patients.. Microscopic features: The tumour is characterized by a prominent squamous proliferation with atypia, keratinous cyst formation and squamous eddies which seem to merge with areas showing eccrine ductal differentiation, including ductular formations in continuity with eccrine ductal epithelium.. ...
The commonest form of breast cancer is ductal carcinoma, which begins while in the cells from the ducts. Breast cancer also can commence inside the cells from the lobules and in other tissues inside the breast. Ductal carcinoma in situ is usually a ailment by which abnormal cells are found in the lining of the ducts Nevertheless they havent unfold outside the house the duct ...
HCC1937BL is a B lymphoblastoid cell line initiated by Epstein-Barr virus (EBV) transformation of peripheral blood lymphocytes obtained from the same patient as HCC1937 (a primary breast ductal carcinoma cell line, ATCC CRL-2336).
Cornfield D B, Schwartz G F, Shen R, McDade T, Kovatich A. (1996, May). Histologic and Immunohistochemical Features of Ductal Carcinoma In Situ of the Breast Recurring After Wide Excision Alone. Presentation presented at: 32nd annual Meeting of the American Soc Clinical Oncol, Philadelphia, PA.. ...
To review the ultrasound (US) patterns of pure ductal carcinoma in situ (DCIS) using a non-mass-like (NML) versus mass-like (ML) classification and to investigate histopathological associations....
I had a small lump in my breast that prompted me to Select a mammogram in February 2015. My final results came back again apparent, that it was just fibrous breast tissue. In Could I began getting Serovital HGH for that increased Vitality statements together with with the anti-getting older Qualities they claimed. I took these often from May well through November, having decided on a 6 thirty day period demo. By November, the lump in my breast experienced much more than doubled in size and had become Significantly more difficult. I went for an additional mammogram and an ultrasound by using a needle biopsy. It came back good. I had stage 2 invasive ductal carcinoma, with lymph node metastasis, which had all developed over a nine thirty day period period of time ...
Breast cancerEdit. Mastectomy specimen containing a very large cancer of the breast (in this case, an invasive ductal carcinoma ... Ductal carcinoma in situ (DCIS) breast cancerEdit. "DCIS patients and control subjects did not differ with respect to oral ... "What You Need To Know About Breast Cancer". National Cancer Institute.. *^ "Definite breast cancer risks". CancerHelp UK. ... Claus EB, Stowe M, Carter D (December 2001). "Breast carcinoma in situ: risk factors and screening patterns". Journal of the ...
... for invasive ductal carcinoma, or for other conditions. DCIS, or intraductal carcinoma, is by definition a breast cancer that ... "Ductal carcinoma in situ". Retrieved 19 March 2013. Additional Sources: Bleicher RJ. Ductal Carcinoma in Situ. Surg Clin N Am ... "Ductal carcinoma in situ". Retrieved 19 March 2013. Desantis C, Siegel R, Bandi P, et al. (2011). "Breast cancer statistics". ... "Sentinel lymph node biopsy in the management of ductal carcinoma in situ". Clin Breast Cancer. 6: 216-222. doi:10.3816/cbc.2005 ...
"IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland". Journal of ... produced by carcinoma cells, acts through paracrine signaling on endothelial cells and through autocrine signaling on carcinoma ... "Autocrine vascular endothelial growth factor signaling in breast cancer. Evidence from cell lines and primary breast cancer ... In HER2 overexpressing breast cancers, the HER2-IL-6-STAT3 signaling relationship could be targeted to develop new therapeutic ...
"The influence of margin width on local control of ductal carcinoma in situ of the breast". The New England Journal of Medicine ... "A prognostic index for ductal carcinoma in situ of the breast". Cancer. John Wiley & Sons. 77 (11): 2267-2274. doi:10.1002/( ... Lewinsky is a board certified radiation oncologist who is among the top 15% of breast cancer researchers in terms of ... Lewinsky has published a number of medical papers in collaboration with several other scientists that focus on breast cancer. ...
"Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of the breast". Am. J ... of clear cell renal carcinomas. Two transcript variants encoding different isoforms have been identified for this gene. Loss of ... "Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau ...
... specimen containing a very large cancer of the breast (in this case, an invasive ductal carcinoma) ... large areas of ductal carcinoma in situ or even those persons that are removing the breast because of the possibility of breast ... an invasive ductal carcinoma of the breast, pale area at the center ... A mastectomy is usually carried out to treat breast cancer. In some cases, people believed to be at high risk of breast ...
... removed from her left breast. The eventual diagnosis was "ductal carcinoma with medullary features".[not in citation given] Due ... "My Breast". New York Magazine. Is DNA Destiny? Utne Reader. March 1, 1998 My Breast by Joyce Wadler on Amazon.com "The Public ... Her memoir about breast cancer, My Breast: One Woman's Cancer Story (ISBN 0671017756; ISBN 978-0-671-01775-0) was originally a ... Wadler has been treated for both breast and ovarian cancer. In 1991, Wadler was diagnosed with breast cancer and had a ...
... lobular carcinoma in situ (LCIS) exhibits perinuclear staining with 34βE12. Ductal carcinoma in situ (DCIS) does not stain for ... Yeh IT, Mies C (March 2008). "Application of immunohistochemistry to breast lesions". Arch. Pathol. Lab. Med. 132 (3): 349-58. ... It can be used to differentiate in situ cancers of the breast; ...
2011). "Role of RNA binding protein HuR in ductal carcinoma in situ of the breast". The Journal of Pathology. 224: 529-539. doi ...
"Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type". The Journal of ... C11orf86 is down-regulated from non-neoplastic mucosa to adenomas and carcinomas, down-regulated in renal cell carcinoma, and ... and carcinomas". Experimental and Molecular Pathology. 90 (2): 201-209. doi:10.1016/j.yexmp.2010.12.004. Hidaka, Hiedo; Seki, ... aberrant expression and functional significance in renal cell carcinoma". Oncotarget. 3 (1): 44-57. doi:10.18632/oncotarget.417 ...
For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... glioma Breast cancer Invasive lobular carcinoma Tubular carcinoma Invasive cribriform carcinoma Medullary carcinoma Male breast ... Nearly all cancers developing in the breast, prostate, lung, pancreas, and colon are carcinomas. Sarcoma: Cancers arising from ... cancer Phyllodes tumor Inflammatory Breast Cancer Adrenocortical carcinoma Islet cell carcinoma (endocrine pancreas) Multiple ...
ISBN 978-0-397-51624-7. Liong, Yee; Hong, Ga; Teo, Jennifer Gek; Lim, Geok (2013). "Breast ductal carcinoma in situ presenting ... Because it is so rare it may be sometimes confused with comedo carcinoma of the breast although the conditions appear to be ... Nonpuerperal breast abscesses have a higher rate of recurrence compared to puerperal breast abscesses. There is a high ... Often minor ductal and periductal inflammation is present. The lesion is in some cases very difficult to distinguish from ...
... gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast". Cancer Science. 100 (4): 580-7. doi:10.1111/j.1349- ...
For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... An invasive ductal carcinoma of the breast (pale area at the center) surrounded by spikes of whitish scar tissue and yellow ... Radiation to the breast reduces the ability of that breast to produce milk and increases the risk of mastitis. Also, when ... for breast cancer, see Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, et al. (February 2009). "Breast ...
"Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case ... It is usually a type of ductal carcinoma in situ. Comedo carcinomas are usually non-infiltrating and intraductal tumors. ... ductal carcinoma. Recurrence and survival rates differ for invasive breast cancer which has originated as comedocarcinoma ... "Prognostic factors in ductal carcinoma in situ of the breast: results of a retrospective study of 575 cases". Eur J Obstet ...
Many genes which are grouped into clusters show the same expression profiles in human invasive ductal breast carcinomas. ... Brain and breast related genes didn't cluster. This shows that at least some clusters consist of functionally related genes. ...
... can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. CAM 5.2, an antibody that ... such as spindle cell carcinoma. It is considered useful in identifying microscopic metastases of breast carcinoma in lymph ... October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients ... 1997). "A two-dimensional gel database of human colon carcinoma proteins". Electrophoresis. 18 (3-4): 605-13. doi:10.1002/elps. ...
"IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland". Journal of ... "Breast Cancer Research. 9 (5): R63. doi:10.1186/bcr1769. PMC 2242658. PMID 17897439.. ... "Autocrine vascular endothelial growth factor signaling in breast cancer. Evidence from cell lines and primary breast cancer ... In breast cancer, the acquisition of tamoxifen resistance is another major therapeutic problem. It has been shown that ...
"Microdissection and SAGE as a combined tool to reveal gene expression in ductal carcinoma in situ of the breast". Mol. Carcinog ... 2006). "Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas". Mutat. Res. 594 (1-2): 78-85. doi ...
Invasive ductal carcinomas of the breast often have a scirrhous, stellate appearance caused by desmoplastic formations. ... Walker, Rosemary A (2001). "The complexities of breast cancer desmoplasia". Breast Cancer Research. 3 (3): 143-5. doi:10.1186/ ... malignant melanoma Desmoplastic squamous cell carcinoma Morpheaform basal cell carcinoma Microcystic adnexal carcinoma ... 2011). "Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs". Nature Medicine. 17 (7 ...
2010). "[Diagnostic and prognostic significance of FOXA1 expression in molecular subtypes of breast invasive ductal carcinomas ... "Expression of FOXA1 and GATA-3 in breast cancer: The prognostic significance in hormone receptor-negative tumours". Breast ... FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 ... 2009). "Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line". Biochem. Biophys. Res. Commun. 386 (1): 30 ...
Invasive ductal carcinoma: 55% of breast cancers Ductal carcinoma in situ: 13% Invasive lobular carcinoma: 5% The vast majority ... Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name- ... "The changing incidence of in situ and invasive ductal and lobular breast carcinomas: United States, 1999-2004". Cancer ... These are divided by total breast cancer incidence (211,300 invasive and 55,700 in situ cases) as reported from Breast Cancer ...
For example, syndecan 1 expression is increased in ductal breast carcinomas and is associated with factors of angiogenesis and ... E-cadherin and c-met is associated with factors of angiogenesis and lymphangiogenesis in ductal breast carcinoma in situ". ... Breast Cancer Research: BCR. 9 (1): R8. doi:10.1186/bcr1641. Kim, H; Choi, DS; Chang, SJ; Han, JH; Min, CK; Chang, KH; Ryu, HS ... syndecan 1 expression has been linked with low differentiation in squamous cell carcinoma of the head and neck . Syndecan 1 ...
7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships". Breast Cancer Res. 7 (2): R238-47. doi: ...
In a more recent study, the expression of PLEKHA7 protein in high grade ductal breast carcinomas, and lobular breast carcinomas ... "The Expression of the Zonula Adhaerens Protein PLEKHA7 Is Strongly Decreased in High Grade Ductal and Lobular Breast Carcinomas ... "Genetic up-regulation and overexpression of PLEKHA7 differentiates invasive lobular carcinomas from invasive ductal carcinomas ... PLEKHA7 was identified by mass spectrometry in lysates of human intestinal carcinoma (Caco-2) cells in a GST-pull down using N- ...
Breast cancer (invasive ductal). Over-expression. -. Immunohistochemistry. . Breast cancer (BRCA1 deficient). Over- ... "Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas". Int. J. Cancer. 88 (1): 28-36. ... Breast cancer (progesteron receptor negative). Over-expression. -. messenger RNA. . Breast cancer. Under-expression. 30%. ... Several alterations of the Rad51 gene have been associated with an increased risk of developing breast cancer. The breast ...
recurrence invasive ductal carcinoma tmouse After having a lumpectomy, chemo and radiation my wife is 2 1/2 years out from ... 12 Ways to Cut Your Breast Cancer Risk Breast cancer is not an inevitability. From what you eat and drink to how much you ... 17 Deadly Rumors About Breast Cancer From mammograms to personal hygiene, learn the truth about these deadly breast cancer ... Dear tmouse, The treatment of recurrent breast cancer varies depending on where the cancer has recurred. The current standards ...
Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: MMTV-Associated, Ductal Carcinoma: Invasive ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: MMTV-Associated, Ductal Carcinoma: Invasive ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: Lobular Carcinoma in Situ (LCIS) ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: Invasive Lobular Carcinoma (ILC) ...
... and Ductal Carcinoma In Situ (DCIS) breast cancers are types that start in the milk ducts. Learn more about how they are ... How Is Ductal Carcinoma in Situ Treated? What Is Ductal Carcinoma?. Ductal carcinoma is a common type of breast cancer that ... What Is Invasive Ductal Carcinoma?. Invasive ductal carcinoma (IDC) accounts for about 80% of all invasive breast cancers in ... What is Ductal Carcinoma in Situ (DCIS)?. Ductal Carcinoma in Situ (DCIS), also known as intraductal carcinoma, accounts for ...
Ductal carcinoma in situ of the breast.. Burstein HJ1, Polyak K, Wong JS, Lester SC, Kaelin CM. ... Ductal carcinoma in situ of the breast. [N Engl J Med. 2004] ... Ductal carcinoma in situ of the breast. [N Engl J Med. 2004] ... Ductal carcinoma in situ of the breast. [N Engl J Med. 2004] ... Ductal carcinoma in situ of the breast. [N Engl J Med. 2004] ... Extramammary recurrence of DCIS after total mastectomy: an iatrogenic displacement following needling procedures? [Breast J. ...
Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast. *Ductal Breast Carcinoma In Situ ... 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ. *Ductal Breast ... Studying Blood Samples From Women With Breast Cancer or Ductal Carcinoma In Situ Who Are Receiving Tamoxifen. *Breast Cancer ... or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer. *Ductal Breast Carcinoma ...
Also get info for medullary, mucinous, papillary and tubular ductal carcinomas. ... treatment and prognosis for invasive ductal carcinoma-from the Johns Hopkins Breast Center in Baltimore, MD. ... Invasive Ductal Carcinoma (IDC). Invasive ductal carcinoma (IDC), also known as infiltrating ductal carcinoma, is cancer that ... Mucinous Ductal Carcinoma - This occurs when cancer cells within the breast produce mucous, which also contains breast cancer ...
The pathology revealed grade 2-3 invasive ductal carcinoma of the right breast and ductal carcinoma in situ of the left breast ... High-grade ductal carcinoma in situ is incredibly rare in male patients. The prognosis for ductal carcinoma in situ (DCIS) in a ... Case Report: Ductal Carcinoma In Situ in the Male Breast. Joshua Chern, Lydia Liao, Raymond Baraldi, Elizabeth Tinney, Karen ... J. Armstrong, C. Saunders, and C. Metcalf, "Male breast ductal carcinoma in situ," ANZ Journal of Surgery, vol. 73, no. 9, pp. ...
Ductal carcinoma in situ (DCIS) of the breast is a noninvasive carcinoma with a wide spectrum of disease, ranging from low- ... E. B. Claus, M. Stowe, and D. Carter, "Oral contraceptives and the risk of ductal breast carcinoma in situ," Breast Cancer ... I. Jiveliouk, B. Corn, M. Inbar, and O. Merimsky, "Ductal carcinoma in situ of the breast in Israeli women treated by breast- ... "Androgen receptor CAG repeat lengths in ductal carcinoma in situ of breast, longest in apocrine variety," Breast, vol. 9, no. 1 ...
14 Studies found for: Breast Ductal Carcinoma , Antimitotic Agents. Also searched for Ductal breast carcinoma, Antimitotic ... Neoadjuvant Therapy in TRIPle Negative Breast Cancer With antiPDL1. *Invasive Ductal Breast Carcinoma ... Combination Chemotherapy With or Without Trastuzumab in Treating Patients With Stage II or Stage III Breast Cancer. *Breast ... Addition of Cisplatin to Adjuvant Chemotherapy for Early Stage Breast Cancer in High-Risk Women. *Tubular Breast Cancer ...
The American Cancer Society estimates that more than 62,000 news cases of carcinoma in situ will be diagnosed this year. A ... A common type of carcinoma in situ called DCIS (ductal carcinoma in situ or intraductal carcinoma). ... Ductal carcinoma in situ (or DCIS) refers to the most common type of noninvasive breast cancer in women. In situ, or in place ... The term, ductal carcinoma in situ (DCIS), refers to a family of cancers that occur in the breast ducts. There are two ...
Prognostic classification of breast ductal carcinoma in situ. Lancet. 1995;345:1154-7.CrossRefPubMedGoogle Scholar ... Estrogen receptors in ductal carcinoma in situ of the breast. Am Surg. 1990;56:436-9.PubMedGoogle Scholar ... Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least 2 different lines of genetic evolution. J ... Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin Cancer Res. 2004;10:5160-7.CrossRefPubMedGoogle ...
Reciprocal expression of Bcl-2 and p53 in breast ductal carcinoma.. Lee WY1, Jin YT, Tzeng CC. ... We analysed 101 invasive ductal carcinomas of the breast for the expression of bcl-2, p53, c-erbB-2, estrogen and progesterone ... between bcl-2 and p53 expression and to clarify their roles in apoptosis in different histological graded breast carcinomas. ... Breast Neoplasms/metabolism*. *Breast Neoplasms/pathology. *Carcinoma, Ductal, Breast/metabolism*. *Carcinoma, Ductal, Breast/ ...
... of the breast is the most common precursor to invasive carcinoma (IC), the second-leading cause of death in women in USA. There ... Ductal carcinoma in situ (DCIS) of the breast is the most common precursor to invasive carcinoma (IC), the second-leading cause ... Silverstein MJ (2000) Ductal carcinoma in situ of the breast. Annu Rev Med 51:17-32. doi:10.1146/annurev.med.51.1.17PubMed ... Invasive Breast Cancer Invasive Ductal Carcinoma Cellular Automaton Apoptotic Index Necrotic Core These keywords were added by ...
... of the breast has increased significantly in Japanese women. It comprises 14.1% (172/1216) of all primary breast cancers at our ... The incidence of ductal carcinoma in situ (DCIS) ... Breast Ductal carcinomain situ Atypical ductal hyperplasia ... Silverstein MJ, Poller DN: van Nuys ductal carcinoma in situ classification. In Ductal carcinoma in situ of the breast. Ed by ... Ductal carcinoma in situ and atypical ductal hyperplasia of the breast diagnosed at stereotactic core biopsy.Breast J 7:14-18, ...
A new genetic-based model may explain how a common form of early-stage breast cancer known as ductal carcinoma in situ ... Tags: Bioinformatics, Breast Cancer, Breast Milk, Cancer, Carcinoma, Cell, DNA, DNA Sequencing, Ductal Carcinoma, Ductal ... Study provides insight into how early-stage breast cancer progresses to invasive ductal carcinoma. *Download PDF Copy ... A new genetic-based model may explain how a common form of early-stage breast cancer known as ductal carcinoma in situ (DCIS) ...
PHILADELPHIA - Six factors were associated with invasive recurrence of breast cancer after a diagnosis of ductal carcinoma in ... Six Factors May Predict Invasive Breast Cancer Recurrence after Ductal Carcinoma in Situ Diagnosis. ... Forty studies met the eligibility criteria of including at least ten invasive breast cancer events and at least one year of ... Finally, the researchers performed meta-analyses on all factors associated with the recurrence of invasive breast cancer ...
Delivered Through the Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast. *Ductal Breast Carcinoma In Situ ... MRI and Gene Expression in Diagnosing Patients With Ductal Breast Cancer In Situ. *Ductal Breast Carcinoma In Situ ... 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ. *Ductal Breast ... A Pilot Clinical Trial to Evaluate the Biological Activity of Fulvestrant in Breast Ductal Carcinoma in Situ (DCIS). *Breast ...
... is the most common form of breast cancer. Find out about IDC symptoms, diagnosis and treatment at Breast Cancer Care. ... Invasive ductal breast cancer is the most common type of breast cancer in both women and men and accounts for about 75% of all ... We use the term invasive ductal breast cancer although this type of breast cancer is also known as: ... Try our new Breast Cancer Care app for moving forward after breast cancer ...
Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast.. Bohlke K1, Cramer DW, ... with risk of breast cancer in a study of 94 cases of premenopausal ductal carcinoma in situ and 76 controls. Compared with ... women in the upper two tertiles of IGF-I had an elevated risk for ductal carcinoma in situ. Conversely, compared with women in ... women in the upper two tertiles of IGFBP-3 had a decreased risk for ductal carcinoma in situ. After grouping women on the basis ...
Carcinoma. Breast Neoplasms. Carcinoma in Situ. Carcinoma, Ductal, Breast. Breast Carcinoma In Situ. Carcinoma, Intraductal, ... Breast Diseases. Skin Diseases. Carcinoma, Ductal. Adenocarcinoma. Neoplasms, Ductal, Lobular, and Medullary. Lapatinib. ... Lapatinib Ditosylate in Treating Patients With Ductal Breast Carcinoma In Situ. The safety and scientific validity of this ... Ductal Breast Carcinoma In Situ HER2/Neu Positive Other: Laboratory Biomarker Analysis Drug: Lapatinib Ditosylate Other: ...
Our work confirms the existence of distinct subpopulations of DCIS lesions, which will likely have utility in breast cancer ... micrographs of biomarkers whose expression correlates with breast cancer aggressiveness are divided by micrographs of ... Although epidemiological studies propose aggressive and non-aggressive forms of ductal carcinoma in situ (DCIS), they cannot be ... subpopulations of DCIS lesions with ratiometric properties resembling either benign fibroadenoma or invasive carcinoma samples ...
Metaplastic ductal carcinoma of the breast accounts for ,1% of all breast carcinomas. This case, which involved a predominant ... of all breast carcinomas.4. Clinically, metaplastic carcinoma has similar features to those of breast carcinoma in general.2,3, ... No suspicious contralateral breast lesion was identified.. Discussion. Metaplastic ductal carcinoma of the breast is a well- ... Radiological Case: Metaplastic ductal carcinoma of the breast. By David T. Boyd, MD, Pouneh Razavi, MD, Pedro Debrito, MD, ...
Forty-four cases were subclinical mammographically-detected carcinomas revealed by the clusters of m ... The role of axillary lymph node dissection for microinvasive ductal carcinoma in situ of the breast was analyzed in a series of ... Breast Neoplasms / pathology*, surgery. Carcinoma, Ductal, Breast / pathology*, surgery. Female. Humans. Lymph Node Excision*. ... The role of axillary lymph node dissection for microinvasive ductal carcinoma in situ of the breast was analyzed in a series of ...
Breast Cancer Res Treat. 2011 Oct;129(3):929-38. doi: 10.1007/s10549-011-1531-1. Epub 2011 May 3. Research Support, Non-U.S. ... Second events following ductal carcinoma in situ of the breast: a register-based cohort study.. Falk RS1, Hofvind S, Skaane P, ... The incidence of ductal carcinoma in situ (DCIS) of the breast has increased in recent decades, particularly, in counties ... Patients with DCIS have an increased risk of both subsequent breast malignancy and breast cancer death compared with women in ...
Buy Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer by Lisa A. Newman, Jessica M. Bensenhaver from ... Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer (Hardback). Lisa A. Newman (editor), Jessica M. Bensenhaver ... Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state- ... "This is a slim but meaty monograph on ductal carcinoma in situ (DCIS) and microinvasive breast cancer. ... The book is ...
TumorCancerMammary ductal caIntraductal carcinomaHyperplasiaSquamousMetastaticPrognosticEpithelial cellsPrognosisBiopsyRadiotherapyMammographyPathologyGrade III invasive ductal carcinomasLymph nodesDiagnosed with invasive ductal carcinomaClinicalInfiltratingPatients with invasiveNeoplasiaSurgeryDuctsMalignantHuman ductalPapillary CarcinomaBenignLobular carcinomasProgressionLobulesHistologicContralateralMetastasesSitu carcinoma
- Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer. (greenmedinfo.com)
- There's either no sign of a tumor in the breast or there is, but it's 20 mm or smaller (T0 or T1, N1, M0). (webmd.com)
- There's no sign of a tumor in the breast. (webmd.com)
- Ai L, Kim WJ, Kim TY, Fields CR, Massoll NA, Robertson KD, Brown KD (2006) Epigenetic silencing of the tumor suppressor cystatin m occurs during breast cancer progression. (springer.com)
- Tumor of the breast and female genital organs. (springer.com)
- Their unique cellular makeup makes treatment more difficult, while a low number of tumor cells in the breast milk ducts make the cells harder to spot due to their scarcity. (news-medical.net)
- The aim of the study was to assess the expression of estrogen (ER) and progesterone (PR) receptors in ductal invasive breast carcinoma not otherwise specified (NOS) according to patient menopausal state and tumor histopathology. (nih.gov)
- A centrosomal serine/threonine kinase, AIK1 3 / breast tumor amplified kinase/aurora2, which was recently identified as an oncogene, shows high amino acid identity with chromosome segregation kinases, fly Aurora, and yeast Ipl1. (aacrjournals.org)
- T. A. Caragine, N. Okada, A. B. Frey, and S. Tomlinson, "A tumor-expressed inhibitor of the early but not late complement lytic pathway enhances tumor growth in a rat model of human breast cancer," Cancer Research , vol. 62, no. 4, pp. 1110-1115, 2002. (hindawi.com)
- Determine the effectiveness of radiofrequency ablation (RFA), in terms of amount of tumor coagulated and viable cell count, in patients with early invasive breast cancer or low- or intermediate-grade ductal carcinoma in situ. (clinicaltrials.gov)
- RFA: Patients undergo RFA comprising insertion of a multiple-needle electrode into the breast tumor under direct guidance of ultrasonography and the metallic clip placed preoperatively in the lesion. (clinicaltrials.gov)
- To improve precision of tumor bed localization and definition of clinical target volume, and to reduce normal tissue irradiation in women undergoing partial breast or breast boost radiotherapy. (clinicaltrials.gov)
- OUTLINE: Patients undergo planned breast-conservation surgery and placement of titanium clips to the four radial, the deep, and superficial margins of the excision cavity (for localization of tumor bed). (clinicaltrials.gov)
- Determine the effect of intraoperative radiotherapy boost to the tumor bed on acute complications after lumpectomy (before whole breast irradiation) in women with ductal carcinoma in situ or invasive adenocarcinoma of the breast. (clinicaltrials.gov)
- Giving radiation during surgery followed by external-beam radiation to the entire breast may kill more tumor cells. (clinicaltrials.gov)
- We conclude that neu overexpression may be an early step in the development of a distinct histologic type of carcinoma of the breast, but we could find no association of overexpression with lymph-node status or tumor recurrence. (nih.gov)
- In a case-control study derived from a cohort of 4661 women with a primary carcinoma in situ of the breast, we investigated age at diagnosis, mode of detection, tumor characteristics, and primary therapy, as prognostic factors for developing invasive breast cancer or dying from breast cancer. (aacrjournals.org)
- We examined the promoter methylation status of Maspin in tumor and corresponding serum of breast cancer patients. (springer.com)
- Lumpectomy refers to the surgical removal of a cancerous lump (or tumor) in the breast along with a small margin of the surrounding normal breast tissue. (imaginis.com)
- Ipsilateral breast tumor recurrence. (ovid.com)
- Tumor grade is an established indicator of breast cancer outcome, although considerable heterogeneity exists even within-grade. (aacrjournals.org)
- BCL9 has been shown to promote tumor metastasis in multiple myeloma and colon carcinoma. (ku.edu)
- While the histological tumor type itself (ductal versus lobular) did not influence the lymph node status, multifocal and diffuse distribution of the lesions were associated with significantly increased risk of lymph node metastases in both ductal and lobular cancers. (diva-portal.org)
- Immunohistochemical examination revealed that the tumor cells tested positive for estrogen receptor and negative for progesterone receptor, which was consistent with primary breast cancer. (springermedizin.de)
- Lumpectomy (sometimes known as a tylectomy) is a surgical removal of a discrete portion or "lump" of breast, usually in the treatment of malignant tumor or breast cancer. (wikipedia.org)
- Adenosquamous carcinoma Refers to a mixed tumor containing both adenocarcinoma and squamous cell carcinoma, wherein each of these cell types comprise at least 10% of the tumor volume. (wikipedia.org)
- In 1991, Wadler was diagnosed with breast cancer and had a malignant tumor "the size of a robin's egg" removed from her left breast. (wikipedia.org)
- Stage I is an invasive breast cancer with the tumor not exceeding 2 cm and absence of lymph node involvement. (wikipedia.org)
- In the current WHO breast tumor classification, these tumors are classified as ductal carcinoma. (wikipedia.org)
- Mutation or over expression of oncogenes can be kept under controlled expression in a very specific cellular context rather than throughout the organism.Another way to model human breast cancer is done through the targeted inhibition of a tumor suppressor gene. (wikipedia.org)
- Stereotactic biopsy, also known as stereotactic core biopsy, is a biopsy procedure that uses a computer and imaging performed in at least two planes to localize a target lesion (such as a tumor or microcalcifications in the breast) in three-dimensional space and guide the removal of tissue for examination by a pathologist under a microscope. (wikipedia.org)
- Classification of breast cancer is usually, but not always, primarily based on the histological appearance of tissue in the tumor. (wikipedia.org)
- It is postulated that high expression and secretion of elongation factors from tumor tissues, combined with altered levels of eEF1A-derived bacterial peptides in neoplastic disease, may lead to autoimmunity in breast cancer. (wikipedia.org)
- E-cadherin acts as an invasion suppressor and a classical tumor suppressor gene in pre-invasive lobular breast carcinoma. (wikipedia.org)
- RRM2 is upregulated within these specific Triple Negative cancer cells leading to a higher rate of drug resistance and inability to slow or stop the tumor progression which leads to more aggressive forms of triple negative breast cancer that are often fatal (Wilson 2016). (wikipedia.org)
- The more detailed map of the vascular network contains information pointing to the location where the breast has changed to accommodate the tumor. (wikipedia.org)
- In the case of a tumor, or even of a precancerous lesion, signs appear to have rounded shapes or which converge from different areas of the breast to 'feed' the tumor. (wikipedia.org)
- The presence of abnormal cells that are not part of the main tumor, such as lymphatic invasion, atypical ductal hyperplasia or lobular carcinoma in situ in breast tissue, may not prevent a margin being graded as R0. (wikipedia.org)
- Several authors have suggested that abnormal Syk function facilitates transformation in Nasopharyngeal carcinoma and head and neck cancer while other authors have suggested a tumor suppressor role in breast and gastric cancer. (wikipedia.org)
- However, in some cancer types KLF4 may act as a tumor promoter where increased KLF4 expression has been reported, such as in oral squamous cell carcinoma and in primary breast ductal carcinoma. (wikipedia.org)
- citation needed] Tumor necrosis factor alpha (TNF alpha) inhibits the growth of MCF-7 breast cancer cells. (wikipedia.org)
- The predominant allele has a normal, tumor suppressive function whereas high penetrance mutations in these genes cause a loss of tumor suppressive function which correlates with an increased risk of breast cancer. (wikipedia.org)
- Alternatively, some patients can choose to have a wide local excision, also known as a lumpectomy, an operation in which a small volume of breast tissue containing the tumor and a surrounding margin of healthy tissue is removed to conserve the breast. (wikipedia.org)
- Both mastectomy and lumpectomy are referred to as "local therapies" for breast cancer, targeting the area of the tumor, as opposed to systemic therapies, such as chemotherapy, hormonal therapy, or immunotherapy. (wikipedia.org)
- Currently, the decision to do the mastectomy is based on various factors, including breast size, the number of lesions, biologic aggressiveness of a breast cancer, the availability of adjuvant radiation, and the willingness of the patient to accept higher rates of tumor recurrences after lumpectomy and radiation. (wikipedia.org)
- Cowden syndrome (also known as Cowden's disease and sometimes as multiple hamartoma syndrome) is a rare autosomal dominant inherited disorder characterized by multiple non-cancerous tumor-like growths called hamartomas, which typically are found in the skin, mucous membranes (mouth, nasal membranes, GI tract), thyroid gland, and breast tissue. (wikipedia.org)
- For instance, in human breast cancer (MCF7) cells, PNKD may promote tumor cell proliferation by activating the MEK/ERK signaling pathway, while in human hepatoma (HepG2) cells, PNKD may operate through the MLC2/FAK/AKT pathway. (wikipedia.org)
- M8082/3 Lymphoepithelial carcinoma Lymphoepithelioma Lymphoepithelioma-like carcinoma Schmincke tumor (C11. (wikipedia.org)
- M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
- Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
- Trichilemmal carcinoma M8103/0 Pilar tumor (C44. (wikipedia.org)
- MammaPrint is a prognostic and predictive diagnostic test for early stage breast cancer patients that assess the risk that a tumor will metastasize to other parts of the body. (wikipedia.org)
- MammaPrint has been prospectively, clinically validated for use in early stage (I and II) breast cancer patients regardless of estrogen receptor (ER) or Human Epidermal Growth Factor Receptor 2 (HER2) status, with a tumor size ≤ 5.0 cm, and 0-3 positive lymph nodes (LN0-1), with no special specifications for N1mi pathology. (wikipedia.org)
- There are no exclusion criteria based on histopathologic tumor type (i.e. ductal, lobular, mixed, etc.) or age. (wikipedia.org)
- To identify a novel and independent predictor of breast cancer recurrence, DNA microarray technology was used to interrogate all 25,000 genes in untreated tumor samples from women where follow-up categorized them as being disease free or having distant metastases within five years. (wikipedia.org)
- The paradigm used to development the 70-GS makes it unique in molecular breast cancer diagnostics because it allowed the tumor biology itself to show the genes most predictive of known patient outcomes. (wikipedia.org)
- See: Tumor-associated endothelial cells 80-90% of cancer are carcinomas, or cancers that form in the epithelial tissue. (wikipedia.org)
- Specifically, DMTXbreastScan helps to determine, at the moment of first diagnosis, if a breast tumor has the capacity to develop metastases. (wikipedia.org)
- Epstein-barr virus, human papillomavirus and mouse mammary tumour virus as multiple viruses in breast cancer. (greenmedinfo.com)
- In a study on in situ breast cancer no lymph node involvement was seen. (greenmedinfo.com)
- Long-term statin use is associated with an increased risk of ductal and lobular breast cancer among women 55-74 years of age. (greenmedinfo.com)
- Dear tmouse, The treatment of recurrent breast cancer varies depending on where the cancer has recurred. (medhelp.org)
- A quick primer on the different ways breast cancer can be treated. (medhelp.org)
- From mammograms to personal hygiene, learn the truth about these deadly breast cancer rumors. (medhelp.org)
- Breast cancer is not an inevitability. (medhelp.org)
- Where Breast Cancer Spreads: 5 most common places. (webmd.com)
- Ductal carcinoma is a common type of breast cancer that starts in cells that line the milk ducts, which carry breast milk to the nipple. (webmd.com)
- Staging is the name for the process doctors use to figure out if and how far breast cancer has spread. (webmd.com)
- Invasive ductal carcinoma (IDC), also known as infiltrating ductal carcinoma, is cancer that began growing in a milk duct and has invaded the fibrous or fatty tissue of the breast outside of the duct. (hopkinsmedicine.org)
- IDC is the most common form of breast cancer, representing 80 percent of all breast cancer diagnoses. (hopkinsmedicine.org)
- As with any breast cancer, there may be no signs or symptoms. (hopkinsmedicine.org)
- At the Johns Hopkins Breast Center, we know how quickly patients want results from a biopsy or scan if there is a suspicion of breast cancer. (hopkinsmedicine.org)
- At Johns Hopkins Medicine, our team of breast cancer specialists is dedicated to developing cutting-edge techniques for surgery , breast reconstruction , chemotherapy , biologic targeted therapy , radiation therapy and other hormonal therapies . (hopkinsmedicine.org)
- Our research allows us to make great strides forward for patients with breast cancer. (hopkinsmedicine.org)
- Mucinous Ductal Carcinoma - This occurs when cancer cells within the breast produce mucous, which also contains breast cancer cells. (hopkinsmedicine.org)
- Papillary Carcinoma - This is a very good prognosis breast cancer that primarily occur in women over the age of 60. (hopkinsmedicine.org)
- Tubular Ductal Carcinoma - This is a rare diagnosis of IDC, making up only two percent of diagnoses of breast cancer. (hopkinsmedicine.org)
- Tubular breast cancer has an excellent prognosis. (hopkinsmedicine.org)
- Search breast cancer topics in the Johns Hopkins Health Library . (hopkinsmedicine.org)
- Learn more about breast cancer research and treatment from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins-one of the world's premier cancer institutions. (hopkinsmedicine.org)
- His sister died at age 58 of metastatic breast cancer and his father succumbed to complications from melanoma. (hindawi.com)
- Additionally, he has a niece who was recently diagnosed with breast cancer. (hindawi.com)
- Focused ultrasound of the right breast in the retroareolar region better demonstrates the biopsy-proven invasive breast cancer. (hindawi.com)
- Generally, male breast cancer presents as an invasive carcinoma. (hindawi.com)
- It is anticipated that new biologic agents, when combined with hormonal agents such as SERMs and aromatase inhibitors, may one day prevent all forms of breast cancer. (hindawi.com)
- Also searched for Ductal breast carcinoma , Antimitotic , and Ductal breast cancer . (clinicaltrials.gov)
- The American Cancer Society estimates that more than 62,000 news cases of carcinoma in situ will be diagnosed this year. (imaginis.com)
- Stage 0 breast cancer is a contained cancer that has not spread beyond the ductal system (to the lymph nodes or other areas of the body). (imaginis.com)
- The presence of intraductal component in the infiltrating carcinoma seems to increase DFS and may be an independent and favorable prognostic factor for breast cancer. (springer.com)
- Risk factors for breast cancer in women with proliferative breast disease. (springer.com)
- The molecular journey from ductal carcinoma in situ to invasive breast cancer. (springer.com)
- Pathological prognostic factors in breast cancer, I: the value of histological grade in breast cancer: experience from a large study with long-term follow-up. (springer.com)
- American Cancer Society (2007) American cancer society breast cancer facts and figures 2007-2008. (springer.com)
- Patients with ADH may have a risk for subsequent breast cancer, because ADH is frequently associated with contralateral breast carcinomas. (springer.com)
- Jpn J Breast Cancer 10:47-60, 1995 (In Japanese). (springer.com)
- Breast Cancer 7:321-325, 2000. (springer.com)
- There is a certain amount of debate surrounding the exact definition of advanced breast cancer (ABC). (news-medical.net)
- Forty studies met the eligibility criteria of including at least ten invasive breast cancer events and at least one year of follow-up. (aacr.org)
- Finally, the researchers performed meta-analyses on all factors associated with the recurrence of invasive breast cancer reported by more than one of these 17 high-quality studies and calculated the average effect size for each factor. (aacr.org)
- Breast cancer not otherwise specified (NOS). (breastcancercare.org.uk)
- It's sometimes referred to as 'no special type' or 'not otherwise specified' because the cells have no particular features that class them as a specific type of breast cancer when examined under the microscope. (breastcancercare.org.uk)
- If you have any questions about breast cancer please contact the Helpline on 0808 800 6000. (breastcancercare.org.uk)
- We evaluated the association of plasma insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) with risk of breast cancer in a study of 94 cases of premenopausal ductal carcinoma in situ and 76 controls. (nih.gov)
- Using BRIM, micrographs of biomarkers whose expression correlates with breast cancer aggressiveness are divided by micrographs of biomarkers whose expression negatively correlates with aggressiveness to create computed micrographs reflecting aggressiveness. (nature.com)
- This increase, however, was not accompanied by a commensurate reduction in the number of advanced breast cancer patients. (nature.com)
- Breast Cancer Res Treat. (nih.gov)
- patients treated with mastectomy and breast-conserving treatment had a 3.8 and 9.8% risk of ipsilateral invasive cancer within 10 years, respectively. (nih.gov)
- Breast cancer mortality was 2.5% within 10 years of follow-up, a fourfold risk compared with the general population. (nih.gov)
- Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer. (waterstones.com)
- Using Autopsy Series To Estimate the Disease "Reservoir" for Ductal Carcinoma in Situ of the Breast: How Much More Breast Cancer Can We Find? (annals.org)
- Should This Woman With Dense Breasts Receive Supplemental Breast Cancer Screening? (annals.org)
- Detection of multicentric breast cancer using dedicated breast PET. (annals.org)
- Invasive micropapillary carcinoma (IMPC) of the breast and triple negative breast cancer (TNBC) are both aggressive subtypes, but little information is available on their comparison. (nih.gov)
- Triple negative breast cancer. (nih.gov)
- Determination of hormone receptors is of utmost importance in planning therapy in patients with breast cancer. (nih.gov)
- The patients were diagnosed with breast cancer and underwent mastectomy. (nih.gov)
- Towards the early detection of ductal carcinoma (a common type of breast cancer) using biomarkers linked to the PPAR(γ) signaling pathway. (nih.gov)
- Breast cancer is a leading cause of morbidity and mortality among women comprising about 12% females worldwide. (nih.gov)
- In the present study, potential biomarker genes involved in the early progression for early diagnosis of breast cancer has been detailed. (nih.gov)
- The gene expression profile database can be a potential tool in the early diagnosis of breast cancer. (nih.gov)
- Although the physiological function(s) of AIK1 kinase during cell division remains to be determined, the markedly high positivity of AIK1 staining in the cancer lesions suggested a possible involvement of its overexpression in the tumorigenesis of some of breast cancer cells. (aacrjournals.org)
- C. W. Elston and I. O. Ellis, "Pathological prognostic factors in breast cancer. (hindawi.com)
- I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up," Histopathology , vol. 19, no. 5, pp. 403-410, 1991. (hindawi.com)
- Selective decrease of serum immunoglobulin G1 as marker for early stages of invasive breast cancer," Breast Cancer Research and Treatment , vol. 64, no. 2, pp. 193-199, 2000. (hindawi.com)
- After treatment, there is still a small chance that cancer will return to the breast. (komen.org)
- This phase II trial studies how well sirolimus works in preventing invasive breast cancer in patients with breast cancer confined to the mammary ducts or lobules of the breast. (cancer.gov)
- PURPOSE: This clinical trial is studying how well radiofrequency ablation followed by surgery works in treating patients with early invasive breast cancer or ductal carcinoma in situ. (clinicaltrials.gov)
- Determine whether RFA energy applied to breast cancer will result in cancer cell death. (clinicaltrials.gov)
- Patients with invasive breast cancer undergo axillary lymph node dissection or sentinel lymph node biopsy (SLNB) for axillary lymph node staging. (clinicaltrials.gov)
- This phase II randomized trial studies how well bupropion hydrochloride works in improving sexual desire in women with breast or gynecological cancer. (centerwatch.com)
- To evaluate the change in endoxifen levels after an increase in tamoxifen citrate dose from 20 mg to 40 mg in women with breast cancer or ductal breast carcinoma in situ with intermediate-metabolizing CYP2D6 genotypes. (clinicaltrials.gov)
- RATIONALE: Collecting samples of blood and tissue from patients with cancer to study in the laboratory may help doctors learn how fluvastatin effects biomarkers related to breast cancer. (clinicaltrials.gov)
- PURPOSE: This randomized phase II trial is studying how fluvastatin effects biomarkers in women undergoing surgery for ductal carcinoma in situ or stage I breast cancer. (clinicaltrials.gov)
- Among those referred to a tertiary centre, breast cancer is found to be the cause of the breast lump in 36% of patients [ 2 ]. (hindawi.com)
- Breast cancer is the most prevalent form of cancer observed in females globally, with 2.1 million persons affected each year. (hindawi.com)
- Neu-protein overexpression in breast cancer. (nih.gov)
- Amplification of the neu proto-oncogene in breast cancer has been reported to correlate with the presence of lymph-node metastases and with a poor prognosis. (nih.gov)
- A Cox proportional hazard model was used to compare adjusted risk of breast cancer among women with high (BI-RADS 3 or 4) versus low (BI-RADS 1 or 2) breast density. (aacrjournals.org)
- Results: During a median follow-up period of 39 months (0-132 months), 133 women developed invasive breast cancer. (aacrjournals.org)
- Substantial evidence supports the hypothesis that breast cancer development occurs through a series of genomic and epigenomic alterations ( 4 , 8 ). (aacrjournals.org)
- Our understanding of the factors that can affect the occurrence of subsequent invasive breast cancer remains limited. (aacrjournals.org)
- Breast cancer incidence is three to six times higher among women with increased breast density compared with age-matched controls with low breast density ( 17 - 21 ). (aacrjournals.org)
- In fact, breast density remains one of the strongest risk factors for invasive breast cancer, second only to deleterious germ line BRCA mutations. (aacrjournals.org)
- Breast cancer is the second most frequent type of neoplasm among women, ( 1 ) representing approximately 22% of new cases diagnosed every year. (scielo.br)
- Hospital-based and forensic autopsy series examining women not known to have had breast cancer during life. (annals.org)
- From all of the women with a primary carcinoma in situ reported to the Swedish Cancer Registry from 1960 through 1992, we selected as cases all of the women with a ductal carcinoma in situ who later died of breast cancer ( n = 39) or who developed a subsequent invasive cancer in either breast ( n = 118). (aacrjournals.org)
- 95% CI, 1.2-12.7) increased the risk of breast cancer death in univariate analysis. (aacrjournals.org)
- The risk pattern by treatment category differed between those who had an ipsilateral invasive cancer and those who either had a contralateral cancer or died from breast cancer. (aacrjournals.org)
- During the last decade, the proportion of CIS 3 among all of the detected cases of breast cancer in Sweden has increased, mainly because of the introduction of a nation-wide mammography-screening program. (aacrjournals.org)
- miR-106b-5p and miR-17-5p might have a role in breast cancer recurrence and progression by suppressing TGF-β activity, leading to early breast cancer carcinogenesis. (springer.com)
- Here we show that downregulation of XRCC1, which interacts with PARP1 and coordinates base excision repair, is an early event in human breast cancer pathogenesis. (aacrjournals.org)
- Our results indicate that aberrant promoter methylation is associated with loss of Maspin immunoreactivity in breast cancer tissues. (springer.com)
- Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer. (springer.com)
- The lipid-reactive oxygen species phenotype of breast cancer. (rsc.org)
- The paper demonstrates that Raman imaging has reached a clinically relevant level in regard to breast cancer diagnosis applications. (rsc.org)
- I was diagnosed for cancer a 2nd time on the same breast. (empowher.com)
- The five most differentially targeted antigens were selected to generate an autoantibody signature for the in situ to invasive breast cancer transition. (aacrjournals.org)
- This study shows the clinical relevance of a combination of 5 antigens, identified by protein microarrays and validated in an independent cohort of 120 samples by ELISA, as a blood-screening signature for the in situ to invasive breast cancer transition determination. (aacrjournals.org)
- The serum markers currently used in clinical settings, including ACE and CA15-3, are mostly used to monitor treatment effectiveness in patients with metastatic breast cancer ( 4 ). (aacrjournals.org)
- Pathological prognostic factors in breast cancer. (nii.ac.jp)
- Conclusion: The findings of this study are comparable to results in the literature on OPS and demonstrate that OPS is an attractive alternative to standard lumpectomy for Canadian general surgeons who treat breast cancer. (medworm.com)
- MRI use varied across geographic areas and demographic characteristics, with higher use in urban areas and for younger women diagnosed with breast cancer. (ahrq.gov)
- The American Cancer Society estimates that 229,060 new cases of invasive breast cancer were diagnosed and 39,920 people died of the disease in the United States in 2012. (ahrq.gov)
- Magnetic resonance imaging (MRI) findings may lead to changes in treatment plans such as wider excisions, unilateral mastectomy, and/or early detection and treatment of contralateral breast cancer. (ahrq.gov)
- Based on its genomic profile, breast cancer can be classified in six subtypes (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched, basal-like, claudin-low, and normal-like). (scielo.br)
- Results were compared to female breast cancer (BC). (eur.nl)
- Robust characterization of this basal group is necessary if it is to have a major impact on management of patients with breast cancer. (aacrjournals.org)
- Breast cancer is a heterogeneous disease with a disparate variety of histological types and a wide spectrum of responsiveness to different treatments, making clinical management difficult. (aacrjournals.org)
- The breast cancer cure rate is at an all-time high, and so is the information - and misinformation - available to patients and their families. (womensvoicesforchange.org)
- In her book, The New Generation Breast Cancer Book: How to Navigate Your Diagnosis and Treatment Options-and Remain Optimistic-in an Age of Information Overload , she describes every possible test and every type of doctor visit, providing a comprehensive, empathetic guide that a newly diagnosed woman (and her family) will want to have at her side. (womensvoicesforchange.org)
- Whenever big news in breast cancer is reported, those of us who are in the thick of it, the physicians actually taking care of women with breast cancer, brace ourselves for the flurry of phone calls, emails and texts from our patients wanting to know one thing: "How does this new development apply to me? (womensvoicesforchange.org)
- As a result there is no place anymore for the "one size fits all" approach in taking care of women with breast cancer. (womensvoicesforchange.org)
- Some of the factors that contribute to decision making about treatment on an individual basis include: age, overall health status, the amount of cancer in the breast, whether or not there is a concern for spread, and of course, what does the patient herself want? (womensvoicesforchange.org)
- 2 Before the 1980s, virtually all women with breast cancer, in situ as well as invasive, were treated with mastectomy. (pubmedcentralcanada.ca)
- In breast cancer, the presence of p53 gene alterations has been associated with worse prognosis. (thescipub.com)
- We support that mutation in p53 gene can be exploited as a prognostic marker for the early diagnosis of breast cancer, although more clinical and epidemiological data is required to establish this claim. (thescipub.com)
- Breast Cancer Research and Treatment, 97(2):173-176. (uzh.ch)
- The familial medical history was negative for breast cancer and work-up of serum hormone levels was normal. (uzh.ch)
- Secondary endpoints were contralateral breast cancer, distant metastasis and death. (diva-portal.org)
- The outcome of breast cancer mortality for [ductal carcinoma in situ] patients is of importance in itself and potential treatments that affect mortality are deserving of study. (ascopost.com)
- In a study reported in JAMA Oncology , Steven A. Narod, MD, FRCPC , of Women's College Research Institute, Women's College Hospital, and the University of Toronto, and colleagues found that the risk of breast cancer mortality was elevated in patients with ductal carcinoma in situ compared with the general population, with risk being higher among younger vs older women and black vs white women. (ascopost.com)
- 1 Approximately half of breast cancer deaths occurred without development of in-breast invasive recurrence. (ascopost.com)
- Breast cancer mortality was not reduced with the prevention of ipsilateral invasive recurrence by the addition of radiotherapy to lumpectomy or with unilateral mastectomy vs lumpectomy. (ascopost.com)
- and 7.1% had a second primary breast cancer. (ascopost.com)
- At 20 years, overall breast cancer-specific mortality was 3.3% (95% confidence interval [CI] = 3.0%-3.6%), with risk being 1.8 times higher vs the general population (standardized mortality ratio = 1.8, 95% CI = 1.7-1.9). (ascopost.com)
- Among 42,250 women who received lumpectomy and radiotherapy, 547 (1.3%) developed ipsilateral invasive recurrence and 163 (0.4%) died from breast cancer. (ascopost.com)
- Among 19,762 women who received lumpectomy without radiotherapy, 595 (3.0%) developed ipsilateral invasive recurrence, and 102 (0.5%) died from breast cancer. (ascopost.com)
- Among 25,527 who received unilateral or bilateral mastectomy, 200 (0.8%) had ipsilateral invasive recurrence and 154 (0.6%) died from breast cancer. (ascopost.com)
- Breast cancer tissue array (mostly ductal carcinoma in situ), including pathology grade, TNM, cli. (lucerna-chem.ch)
- Radiotherapy improves overall survival in women with locally excised ductal carcinoma in situ, and improves breast cancer-specific survival particularly in estrogen receptor (ER)-negative/borderline and younger patients, according to an analysis published in the journal OncoTargets and Therapy . (oncologynurseadvisor.com)
- Previous research has shown that radiotherapy decreases the incidence of local recurrence after breast-conserving surgery in patients with ductal carcinoma in situ, but there was limited evidence demonstrating the impact of radiotherapy on survival, both overall and breast cancer-specific, in patients with locally excised ductal carcinoma in situ. (oncologynurseadvisor.com)
- however, after stratifying by ER status and age, researchers found that radiotherapy was beneficial for improving breast cancer-specific survival in ER-negative patients and patients under 50 years of age. (oncologynurseadvisor.com)
- Overall survival (OS) and breast cancer-specific survival (BCSS) were compared among patients who received RT or no RT using the Kaplan-Meier methods and Cox proportional hazards regression models. (oncologynurseadvisor.com)
- Correlation of estrogen, progesterone and androgen receptors in breast cancer. (bmj.com)
- Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. (bmj.com)
- Background: HER2 is a well-established prognostic and predictive factor in invasive breast cancer. (diva-portal.org)
- HER2 status in relation to new ipsilateral events (IBE) and Invasive Breast Cancer Recurrences, local or distant (IBCR) was assessed by Kaplan-Meier survival analyses and Cox proportional hazards regression models. (diva-portal.org)
- Eighteen women died from breast cancer and another 114 had died from other causes. (diva-portal.org)
- The pathology of lobular carcinoma in situ in a male as well as screening MRI surveillance of male patients at high risk for breast cancer are discussed, emphasizing the importance of screening and imaging follow up in men who are at high risk for breast cancer. (jcancer.org)
- HER2 is an established negative prognostic factor in invasive breast cancer [ 11 ]. (biomedcentral.com)
- An approximation of the gene expression based subtypes using immunohistochemical (IHC) detection of HER2, estrogen receptor- (ER) and progesterone receptor (PR) expression has been suggested for invasive breast cancer [ 20 ]. (biomedcentral.com)
- Gallbladder metastasis from breast cancer, especially from ductal carcinoma, is rare. (springermedizin.de)
- A 78-year-old woman presented with right upper abdominal tenderness and positive Murphy's sign during chemotherapy for advanced multiple metastases of the breast cancer. (springermedizin.de)
- In conclusion, gallbladder metastasis should be considered in patients with multiple metastatic breast cancer who present with signs or symptoms of cholecystitis. (springermedizin.de)
- Inflammatory metastatic breast cancer with gallbladder metastasis: an incidental finding. (springermedizin.de)
- Acute acalculous cholecystitis due to breast cancer metastasis to the cystic duct. (springermedizin.de)
- Gallbladder metastases of breast cancer: from clinical-pathological patterns to diagnostic and therapeutic strategy. (springermedizin.de)
- Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. (ru.nl)
- Thus it might be a link between obesity and breast cancer. (scitechnol.com)
- In this project we tried to study causative association of obesity and serum leptin with invasive ductal breast cancer (IDC) in a sample of Malaysian population. (scitechnol.com)
- Since high serum leptin in IDC patients persists unabated in the post-operative state, we infer that the source of leptin in these cases cannot be the breast cancer tissue itself and leptin cannot be a marker for breast cancer. (scitechnol.com)
- Highly significant association between serum leptin and IDC patients suggests that leptin in serum might play a causative role in the tumorigenesis of breast cancer, and it might be an important connection between obesity and breast cancer. (scitechnol.com)
- They showed that CXCR4 is highly expressed in malignant breast cancer but not in normal breast tissue, and the ligand SDF-1 was highly expressed in bone marrow, lung and lymph nodes, where breast cancer cells metastasize preferentially. (biomedcentral.com)
- Moreover, they demonstrated that neutralization with a specific monoclonal antibody against CXCR4 effectively inhibited the metastasis of breast cancer cells to the lung or lymph nodes in mice. (biomedcentral.com)
- Representational difference analysis was used in an attempt to identify genetic alterations related to breast cancer metastasis by comparing genomic DNA from microdissected normal cells and from metastatic cells of ductal breast carcinoma patients. (biomedcentral.com)
- Clin Breast Cancer. (wikipedia.org)
- In situ means "in place" and refers to the fact that the abnormal cells have not moved out of the mammary duct and into any of the surrounding tissues in the breast ("pre-cancerous" refers to the fact that it has not yet become an invasive cancer). (wikipedia.org)
- About 20-30% of those who do not receive treatment develop breast cancer. (wikipedia.org)
- The risk factors for developing this condition are similar to those for invasive breast cancer. (wikipedia.org)
- Women considered at higher risks are those who have a family history of breast cancer, those who have had their periods at an early age or who have had a late menopause. (wikipedia.org)
- Carcinoma is a type of cancer that develops from epithelial cells. (wikipedia.org)
- Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal and ectodermal germ layer during embryogenesis. (wikipedia.org)
- Invasive carcinoma of no special type (NST) is the most common form of invasive breast cancer. (wikipedia.org)
- It accounts for 55% of breast cancer incidence upon diagnosis, according to statistics from the United States in 2004. (wikipedia.org)
- The cancer may form from the precancerous lesion called ductal carcinoma in situ. (wikipedia.org)
- Breast cancer (Infiltrating ductal carcinoma of the breast) assayed with anti HER-2 (ErbB2) antibody. (wikipedia.org)
- Salivary duct carcinoma, abbreviated SDC, is a rare type of aggressive cancer that arises from the salivary glands. (wikipedia.org)
- citation needed] Wadler has been treated for both breast and ovarian cancer. (wikipedia.org)
- citation needed] Books My Breast: One Woman's Cancer Story Liaison: The True Story of the M. Butterfly Affair Wadler, Joyce (April 1992). (wikipedia.org)
- Male breast cancer (male breast neoplasm) is a rare cancer in males that originates from the breast. (wikipedia.org)
- Many males with breast cancer have inherited a BRCA mutation, but there are other causes, including alcohol abuse and exposure to certain hormones and ionizing radiation. (wikipedia.org)
- As it presents a similar pathology as female breast cancer, assessment and treatment relies on experiences and guidelines that have been developed in female patients. (wikipedia.org)
- While intraductal cancer, inflammatory carcinoma, and Paget's disease of the nipple have been described, lobular carcinoma in situ has not been seen in males. (wikipedia.org)
- Breast cancer in males spreads via lymphatics and blood stream like female breast cancer. (wikipedia.org)
- Accordingly, the TNM staging system for breast cancer is the same for males and females. (wikipedia.org)
- In a larger study from Finland the average size of a male breast cancer lesion was 1.8 cm. (wikipedia.org)
- Male breast cancer can recur locally after therapy, or can become metastatic. (wikipedia.org)
- it is the same as in female breast cancer and facilitates treatment and analysis. (wikipedia.org)
- Stage III is divided into three subcategories: In IIIA there is breast cancer with axillary lymph nodes clumped together or attached to other structures. (wikipedia.org)
- There are significant differences between male and female breast cancer. (wikipedia.org)
- Almost half of male breast cancer patients are stage III or IV. (wikipedia.org)
- With the relative infrequency of male breast cancer, randomized studies are lacking. (wikipedia.org)
- Treatment largely follows patterns that have been set for the management of postmenopausal breast cancer. (wikipedia.org)
- Lewinsky is a board certified radiation oncologist who is among the top 15% of breast cancer researchers in terms of publication volume, according to Vitals.com. (wikipedia.org)
- Lewinsky has published a number of medical papers in collaboration with several other scientists that focus on breast cancer. (wikipedia.org)
- Comedocarcinoma is one kind of breast cancer which is most commonly very early-stage which demonstrates central necrosis. (wikipedia.org)
- Recurrence and survival rates differ for invasive breast cancer which has originated as comedocarcinoma compared with other types of cancer cells. (wikipedia.org)
- Breast cancer is cancer that develops from breast tissue. (wikipedia.org)
- Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, fluid coming from the nipple, or a red scaly patch of skin. (wikipedia.org)
- Risk factors for developing breast cancer include being female, obesity, lack of physical exercise, drinking alcohol, hormone replacement therapy during menopause, ionizing radiation, early age at first menstruation, having children late or not at all, older age, and family history. (wikipedia.org)
- Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply the ducts with milk. (wikipedia.org)
- In addition, there are more than 18 other sub-types of breast cancer. (wikipedia.org)
- The diagnosis of breast cancer is confirmed by taking a biopsy of the concerning lump. (wikipedia.org)
- Once the diagnosis is made, further tests are done to determine if the cancer has spread beyond the breast and which treatments it may respond to. (wikipedia.org)
- The balance of benefits versus harms of breast cancer screening is controversial. (wikipedia.org)
- The medications tamoxifen or raloxifene may be used in an effort to prevent breast cancer in those who are at high risk of developing it. (wikipedia.org)
- Outcomes for breast cancer vary depending on the cancer type, extent of disease, and person's age. (wikipedia.org)
- Worldwide, breast cancer is the leading type of cancer in women, accounting for 25% of all cases. (wikipedia.org)
- The first noticeable symptom of breast cancer is typically a lump that feels different from the rest of the breast tissue. (wikipedia.org)
- More than 80% of breast cancer cases are discovered when the woman feels a lump. (wikipedia.org)
- Lumps found in lymph nodes located in the armpits can also indicate breast cancer. (wikipedia.org)
- Indications of breast cancer other than a lump may include thickening different from the other breast tissue, one breast becoming larger or lower, a nipple changing position or shape or becoming inverted, skin puckering or dimpling, a rash on or around a nipple, discharge from nipple/s, constant pain in part of the breast or armpit, and swelling beneath the armpit or around the collarbone. (wikipedia.org)
- Pain ("mastodynia") is an unreliable tool in determining the presence or absence of breast cancer, but may be indicative of other breast health issues. (wikipedia.org)
- Inflammatory breast cancer is a particular type of breast cancer which can pose a substantial diagnostic challenge. (wikipedia.org)
- As inflammatory breast cancer does not present as a lump there can sometimes be a delay in diagnosis. (wikipedia.org)
- Another reported symptom complex of breast cancer is Paget's disease of the breast. (wikipedia.org)
- Exceptions include CIS of the colon (polyps), the bladder (preinvasive papillary cancer), or the breast (ductal carcinoma in situ or lobular carcinoma in situ). (wikipedia.org)
- Invasive carcinoma, usually simply called cancer, has the potential to invade and spread to surrounding tissues and structures, and may eventually be lethal. (wikipedia.org)
- Carcinoma in situ is, by definition, a localized phenomenon, with no potential for metastasis unless it progresses into cancer. (wikipedia.org)
- The basal-like carcinoma is a recently proposed subtype of breast cancer defined by its gene expression and protein expression profile. (wikipedia.org)
- In the U.S., they are more frequent among black women, which may explain the higher breast cancer mortality rate in this group. (wikipedia.org)
- The goal of mammography is the early detection of breast cancer, typically through detection of characteristic masses and/or microcalcifications. (wikipedia.org)
- These task force reports point out that in addition to unnecessary surgery and anxiety, the risks of more frequent mammograms include a small but significant increase in breast cancer induced by radiation. (wikipedia.org)
- The Cochrane Collaboration (2013) concluded that the trials with adequate randomisation did not find an effect of mammography screening on total cancer mortality, including breast cancer, after 10 years. (wikipedia.org)
- The authors of systematic review write: "If we assume that screening reduces breast cancer mortality by 15% and that overdiagnosis and overtreatment is at 30%, it means that for every 2000 women invited for screening throughout 10 years, one will avoid dying of breast cancer and 10 healthy women, who would not have been diagnosed if there had not been screening, will be treated unnecessarily. (wikipedia.org)
- They conclude that "it therefore no longer seems reasonable to attend" for breast cancer screening at any age, and warn of misleading information on the internet. (wikipedia.org)
- Tomosynthesis is now Food and Drug Administration (FDA) approved for use in breast cancer screening. (wikipedia.org)
- Breast MRI, an alternative to mammography, has shown substantial progress in the detection of breast cancer. (wikipedia.org)
- Metastatic breast cancer represents the most devastating attribute of cancer and it is considered an advanced-stage event. (wikipedia.org)
- Human breast cancer metastasizes to multiple distant organs such as the brain, lungs, bones and liver. (wikipedia.org)
- Breast cancer is consensually considered genetically and clinically as a heterogeneous disease, in that it reflects the heterogeneity of the normal breast tissue at its origin17873350. (wikipedia.org)
- It also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective metastases. (wikipedia.org)
- Breast cancer phenotypes periodically express genes in metastasis that are indispensable for the metastatic process. (wikipedia.org)
- Targeted expression of oncogenes in mouse mammary epithelial cells is a way of modeling human breast cancer. (wikipedia.org)
- LCIS (lobular neoplasia is considered pre-cancerous) is an indicator (marker) identifying women with an increased risk of developing invasive breast cancer. (wikipedia.org)
- Furthermore, in human breast cancer, interference with the de-regulated Wnt signaling pathway reduces proliferation and survival of cancer. (wikipedia.org)
- For example, the most common type of breast cancer is called ductal carcinoma of the breast. (wikipedia.org)
- Here, the adjective ductal refers to the appearance of the cancer under the microscope, which suggests that it has originated in the milk ducts. (wikipedia.org)
- Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle cell carcinoma, and small-cell carcinoma. (wikipedia.org)
- Although no causal relation with breast cancer has been established, there appears to be an increased statistical risk of breast cancer, warranting a long-term surveillance of patients diagnosed with non-puerperal mastitis. (wikipedia.org)
- The lesion is in some cases very difficult to distinguish from breast cancer. (wikipedia.org)
- The histomorphologic appearance can mimic invasive ductal carcinoma, the most common type of invasive breast cancer. (wikipedia.org)
- Breast Breast cancer Epithelial-myoepithelial carcinoma Low mag. (wikipedia.org)
- Medullary breast carcinoma is a rare type of breast cancer that often can be treated successfully. (wikipedia.org)
- This is the only breast cancer associated with a loss of function mutation in BRCA1, and thus the only form associated with a hereditary mutation. (wikipedia.org)
- HER2/NEU over-expression is associated with sporadic breast cancer. (wikipedia.org)
- Atypical ductal hyperplasia, abbreviated ADH, is the term used for a benign lesion of the breast that indicates an increased risk of breast cancer. (wikipedia.org)
- In the context of a core (needle) biopsy, ADH is considered an indication for a breast lumpectomy, also known as a surgical (excisional) biopsy, to exclude the presence of breast cancer. (wikipedia.org)
- If ADH is found on a core (needle) biopsy (a procedure which generally does not excise a suspicious mammographic abnormality), a surgical biopsy, i.e. a breast lumpectomy, to completely excise the abnormality and exclude breast cancer is the typical recommendation. (wikipedia.org)
- The relative risk of breast cancer based on a median follow-up of 8 years, in a case control study of US registered nurses, is 3.7. (wikipedia.org)
- Ductal carcinoma in situ Breast cancer Collagenous spherulosis Low mag. (wikipedia.org)
- FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. (wikipedia.org)
- Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. (wikipedia.org)
- Stereotactic core biopsy is extensively used by radiologists specializing in breast imaging to obtain tissue samples containing microcalcifications, which can be an early sign of breast cancer. (wikipedia.org)
- IRS-1 protein is known to be involved in various types of cancer, including colorectal, lung, prostate and breast cancer. (wikipedia.org)
- Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose. (wikipedia.org)
- The effectiveness of a specific treatment is demonstrated for a specific breast cancer (usually by randomized, controlled trials). (wikipedia.org)
- That treatment may not be effective in a different breast cancer. (wikipedia.org)
- Treatment algorithms rely on breast cancer classification to define specific subgroups that are each treated according to the best evidence available. (wikipedia.org)
- A variant from this approach, defined on the basis of physical exam findings, is that inflammatory breast cancer (IBC), a form of ductal carcinoma or malignant cancer in the ducts, is distinguished from other carcinomas by the inflamed appearance of the affected breast, which correlates with increased cancer aggressivity. (wikipedia.org)
- Description of a breast cancer would optimally include all of these classification aspects, as well as other findings, such as signs found on physical exam. (wikipedia.org)
- Carcinoma in situ is proliferation of cancer cells within the epithelial tissue without invasion of the surrounding tissue. (wikipedia.org)
- Perineural and/or lymphovascular space invasion is usually considered as part of the histological description of a breast cancer, and when present may be associated with more aggressive disease. (wikipedia.org)
- Grading focuses on the appearance of the breast cancer cells compared to the appearance of normal breast tissue. (wikipedia.org)
- The TNM classification for staging breast cancer is based on the size of the cancer where it originally started in the body and the locations to which it has travelled. (wikipedia.org)
- Metastatic breast cancer has a less favorable prognosis. (wikipedia.org)
- Breast cancer cells may or may not have many different types of receptors, the three most important in the present classification being: estrogen receptor (ER), progesterone receptor (PR), and HER2/neu. (wikipedia.org)
- Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name-however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal cancer, esophageal squamous cell carcinoma. (wikipedia.org)
- Invasive lobular carcinoma accounts for 5-10% of invasive breast cancer. (wikipedia.org)
- Histology and Immunophenotype of Invasive Lobular Breast Cancer. (wikipedia.org)
- One alternative to mammography, Breast MRI or contrast enhanced magnetic resonance imaging (MRI), has shown substantial progress in the detection of breast cancer. (wikipedia.org)
- Screening for malignancy in women with greater than 20% lifetime risk of breast cancer. (wikipedia.org)
- Breast cancer https://www.acr.org/~/media/2a0eb28eb59041e2825179afb72ef624.pdf Magnetic Resonance Imaging of the Breast DeMartini W, Lehman C, Partridge S (April 2008). (wikipedia.org)
- Upregulation of eEF1A has been reported in breast cancer samples. (wikipedia.org)
- As with breast cancer, upregulation of eEF1A expression is associated with prostate cancer and worsened metastasis-free and overall patient survival. (wikipedia.org)
- Paget's disease of the breast is a type of cancer that outwardly may have the appearance of eczema, with skin changes involving the nipple of the breast. (wikipedia.org)
- The condition in itself often appears innocuous, limited to a surface appearance and it is sometimes dismissed, although actually indicative of underlying breast cancer. (wikipedia.org)
- Paget's disease of the breast is a type of cancer of the breast. (wikipedia.org)
- Chemotherapy and/or radiotherapy may be necessary, but the specific treatment often depends on the characteristics of the underlying breast cancer. (wikipedia.org)
- Invasive cancer or extensive ductal carcinoma in situ is primarily treated with modified radical mastectomies. (wikipedia.org)
- Patients suffering from cancer that has not spread beyond the nipple and the surrounding area are often treated with breast-conserving surgery or lumpectomy. (wikipedia.org)
- A breast-conserving surgery consists in the removal of the nipple, areola and the part of the breast that is affected by cancer. (wikipedia.org)
- Paget's disease of the breast is almost always associated with an underlying invasive malignancy, i.e. breast cancer (e.g. mammary ductal carcinoma). (wikipedia.org)
- Metaplastic carcinoma is cancer that begins in cells that have changed into another cell type (for example, a squamous cell of the esophagus changing to resemble a cell of the stomach). (wikipedia.org)
- Metaplastic carcinoma is a relatively uncommon type of cancer with treatment generally similar to that of invasive ductal carcinoma of no special type. (wikipedia.org)
- Whether LVI is a significant prognostic factor in breast cancer is widely debated, and there is no clear consensus. (wikipedia.org)
- NDUFS3 has also been implicated in breast cancer and ductal carcinoma and, thus, may serve as a novel biomarker for tracking cancer progression and invasiveness. (wikipedia.org)
- E-cadherin is also used by pathologists to diagnose different kinds of breast cancer. (wikipedia.org)
- Triple-negative breast cancer (sometimes abbreviated TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR) or Her2/neu. (wikipedia.org)
- There is conflicting information over prognosis for the various subtypes but it appears that the Nottingham prognostic index is valid and hence general prognosis is rather similar with other breast cancer of same stage, except that more aggressive treatment is required. (wikipedia.org)
- One known cause of triple negative breast cancer is germline mutations. (wikipedia.org)
- Rare forms of triple-negative breast cancer are apocrine and squamous carcinoma. (wikipedia.org)
- Inflammatory breast cancer is also frequently triple negative. (wikipedia.org)
- This allows for a higher rate of breast-conserving surgeries and by evaluating the response to the chemotherapy gives important clues about the individual responsiveness of the particular cancer to chemotherapy. (wikipedia.org)
- Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. (wikipedia.org)
- In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients. (wikipedia.org)
- Over-expression is also known to occur in ovarian, stomach, adenocarcinoma of the lung and aggressive forms of uterine cancer, such as uterine serous endometrial carcinoma, e.g. (wikipedia.org)
- HER-2 is over-expressed in approximately 7-34% of patients with gastric cancer and in 30% of salivary duct carcinomas. (wikipedia.org)
- One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. (wikipedia.org)
- As of November 2015, there are a number of ongoing and recently completed clinical trials of novel targeted agents for HER2+ metastatic breast cancer, e.g. margetuximab. (wikipedia.org)
- Laura Esserman is a surgeon and breast cancer oncology specialist who practices at the University of California, San Francisco School of Medicine. (wikipedia.org)
- She believes that some patients with a type of breast cancer, ductal carcinoma in situ, should be placed on active surveillance instead of undergoing a biopsy, mastectomy or lumpectomy. (wikipedia.org)
- Dynamic angiothermography (DATG) is a technique for the diagnosis of breast cancer. (wikipedia.org)
- It is currently used in combination with other techniques for diagnosis of breast cancer. (wikipedia.org)
- In the early 1970s, studies of Prof. J. Tricoire in France focused on the application of contact thermography for the screening of breast cancer using plates with liquid crystals. (wikipedia.org)
- The lesion is in some cases very difficult to distinguish from breast cancer and other causes such as infections (tuberculosis, syphilis, corynebacterial infection, mycotic infection), autoimmune diseases (sarcoidosis, granulomatosis with polyangiitis), foreign body reaction and granulomatous reaction in a carcinoma must be excluded. (wikipedia.org)
- In resections for breast cancer there appears to be a difference between European and American radiation oncologists, with the former preferring larger margins of over 5 mm. (wikipedia.org)
- The company focuses on the development and marketing of pharmaceuticals for the treatment of breast conditions, including breast cancer. (wikipedia.org)
- The company is named after the Persian Queen Atossa, who became the first woman in recorded history with breast cancer around 470 B.C. In 2000, Dr. Steven Quay, a physician specializing in biological chemistry, invented a preventative screening method to identify precursors to breast cancer and to treat precancerous lesions. (wikipedia.org)
- Atossa Genetics is sponsoring a Phase 2 clinical trial, on the use of fulvestrant administered through a microcatheter into the lactiferous duct as neoadjuvant treatment for ductal carcinoma in situ and invasive breast cancer. (wikipedia.org)
- the "SG" subscript indicates salivary gland)) is a salivary gland neoplasm that shares a genetic mutation with certain types of breast cancer. (wikipedia.org)
- This mutant fusion gene also occurs in congenital fibrosarcoma, congenital mesoblastic nephroma, secretory breast cancer (also termed juvenile breast cancer), acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma. (wikipedia.org)
- In partnership with the U.S. Department of Health and Human Services, the National Institutes of Health, the National Cancer Institute, and the Agency for Health Research and Quality, the Cancer Prevention and Treatment Fund/NRC produced Surgery Choices for Women with Early Stage Breast Cancer[better source needed] and a Spanish language version, Las primeras etapas del cancer de seno. (wikipedia.org)
- The Fund developed an online Medscape Continuing Medical Education (CME) course for medical professionals on breast cancer treatment options. (wikipedia.org)
- Breast cancer awareness is an effort to raise awareness and reduce the stigma of breast cancer through education on symptoms and treatment. (wikipedia.org)
- Supporters hope that greater knowledge will lead to earlier detection of breast cancer, which is associated with higher long-term survival rates, and that money raised for breast cancer will produce a reliable, permanent cure. (wikipedia.org)
- Breast cancer advocacy and awareness efforts are a type of health advocacy. (wikipedia.org)
- Breast cancer advocates raise funds and lobby for better care, more knowledge, and more patient empowerment. (wikipedia.org)
- Breast cancer culture, sometimes called pink ribbon culture, is the cultural outgrowth of breast cancer advocacy, the social movement that supports it, and the larger women's health movement. (wikipedia.org)
- The pink ribbon is the most prominent symbol of breast cancer awareness, and in many countries the month of October is National Breast Cancer Awareness Month. (wikipedia.org)
- Some national breast cancer organizations receive substantial financial support from corporate sponsorships. (wikipedia.org)
- The goal of breast cancer awareness campaigns is to raise the public's "brand awareness" for breast cancer, its detection, its treatment, and the need for a reliable, permanent cure. (wikipedia.org)
- Generally speaking, breast cancer awareness campaigns have been highly effective in getting attention for the disease. (wikipedia.org)
- Breast cancer advocacy uses the pink ribbon and the color pink as a concept brand to raise money and increase screening. (wikipedia.org)
- The breast cancer brand is strong: people who support the "pink brand" are members of the socially aware niche market, who are in favor of improved lives for women, believe in positive thinking, trust biomedical science to be able to solve any problem if given enough money, and prefer curative treatments to prevention. (wikipedia.org)
- The brand ties together fear of cancer, hope for early identification and successful treatment, and the moral goodness of women with breast cancer and anyone who visibly identifies themselves with breast cancer patients. (wikipedia.org)
- This brand permits and even encourages people to substitute conscientious consumption and individual symbolic actions, like buying or wearing a pink ribbon, for concrete, practical results, such as collective political action aimed at discovering non-genetic causes of breast cancer. (wikipedia.org)
- The establishment of the brand and the entrenchment of the breast cancer movement has been uniquely successful, because no countermovement opposes the breast cancer movement or believes that breast cancer is desirable. (wikipedia.org)
- A pink ribbon is a symbol of breast cancer awareness. (wikipedia.org)
- It may be worn to honor those who have been diagnosed with breast cancer, or to identify products that a manufacturer would like to sell to consumers that are interested in breast cancer. (wikipedia.org)
- It encourages individuals to focus on the emotionally appealing ultimate vision of a cure for breast cancer, rather than the reality that there is no certain cure for breast cancer, and no guarantee there will ever be such a cure. (wikipedia.org)
- The practice of blindly wearing or displaying a pink ribbon without making other, more concrete efforts to cure breast cancer has been described as a kind of slacktivism due to its lack of real effects, and has been compared to equally simple yet ineffective "awareness" practices like the drive for women to post the colors of their bras on Facebook. (wikipedia.org)
- Critics say that the feel-good nature of pink ribbons and "pink consumption" distracts society from the lack of progress in curing breast cancer. (wikipedia.org)
- Each year, the month of October is recognized as National Breast Cancer Awareness Month by many governments, the media, and cancer survivors. (wikipedia.org)
- The month-long campaign has been called Pinktober because of the increased production of pink goods for sale, and National Breast Cancer Industry Month by critics like Breast Cancer Action. (wikipedia.org)
- The organization that runs the official NBCAM aims to promote mammography and other forms of early detection as the most effective means of fighting breast cancer. (wikipedia.org)
- More recently he has determined the safety on fat derived stem cells for breast reconstruction after mastectomy as long as there is no evidence of cancer. (wikipedia.org)
- Pre-cancer of the breast is a precancerous condition of the breast. (wikipedia.org)
- It may eventually develop into breast cancer. (wikipedia.org)
- KLF4 is an anti-tumorigenic factor and its expression is often lost in various human cancer types, such as Colorectal cancer, gastric cancer, esophageal squamous cell carcinoma, intestinal cancer, prostate cancer, bladder cancer and lung cancer. (wikipedia.org)
- The benefits of screening in breast cancer are controversial. (wikipedia.org)
- In females, the most common types are breast cancer, colorectal cancer, lung cancer and cervical cancer. (wikipedia.org)
- Mice lacking Akt2 show worse outcome in breast cancer initiated by the large T antigen as well as the neu oncogene. (wikipedia.org)
- MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman. (wikipedia.org)
- Her cells were the source of much of current knowledge about breast cancer. (wikipedia.org)
- MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline-based survey. (wikipedia.org)
- Toxicological issues prevented long term use of clomifene and further drug development for other potential applications such as breast cancer treatment and prevention. (wikipedia.org)
- It was another ten years before tamoxifen was approved in December 1977, not as a contraceptive but as a hormonal treatment to treat and prevent breast cancer. (wikipedia.org)
- Toremifene has been shown to be compatible with tamoxifen, and in 1996 it was approved for use in the treatment of breast cancer in postmenopausal women. (wikipedia.org)
- Raloxifene originally failed as a breast cancer drug due to its poor performance in comparison to tamoxifen in the laboratory but the estrogenic effects of raloxifene on bone led to its rediscovery and approval in 1997. (wikipedia.org)
- It was approved for prevention and treatment of osteoporosis and was the first clinically available SERM to prevent both osteoporosis and breast cancer. (wikipedia.org)
- Including treatment of ovulatory dysfunction in the management of infertility, treatment and prevention of postmenopausal osteoporosis, treatment and reduction in risk of breast cancer and treatment of dyspareunia due to menopause. (wikipedia.org)
- SERMs are used dependent on their pattern of action in various tissues: Tamoxifen is a first-line hormonal treatment of ER-positive metastatic breast cancer. (wikipedia.org)
- It is used for breast cancer risk reduction in women at high risk, and as adjuvant treatment of axillary node-negative and node-positive, ductal carcinoma in situ. (wikipedia.org)
- For example, MTA3 expression is downregulated in breast cancer and endometrioid adenocarcinomas. (wikipedia.org)
- MTA3 is overexpressed in non-small cell lung cancer and human placenta and chorionic carcinoma cells. (wikipedia.org)
- In breast cancer, loss of MTA3 promotes EMT and invasiveness of breast cancer cells via upregulating Snail, which in turn represses E-cadherin adhesion molecule. (wikipedia.org)
- In the mammary epithelium and breast cancer cells, MTA3 is an estrogen regulated gene and part of a larger regulatory network involving MTA1 and MTAs, all modifiers of hormone response, and participate in the processes involved in growth and differentiation. (wikipedia.org)
- The estrogen receptor-stimulates the expression of MTA3 in breast cancer cells. (wikipedia.org)
- The β-elemene - a traditional Chinese medicine, upregulates MTA3's expression in breast cancer cells The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition (EMT), Wnt4 expression in mammary epithelial cells, and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets. (wikipedia.org)
- Sir George Lenthal Cheatle KCB CVO FRCS (13 June 1865 - 2 January 1951) was a British surgeon who made important contributions to the diagnosis and treatment of breast cancer. (wikipedia.org)
- Cheatle was interested in carcinomas throughout his career, and particularly cancer of the breast. (wikipedia.org)
- Using them, he was able to prove that Paget's disease of the breast was the result of an underlying breast cancer, and that the calls that are now called carcinoma in situ was not pre-cancerous or potentially cancerous, but were in fact already malign. (wikipedia.org)
- Based on his studies of whole-organ sections, Cheatle proposed that epithelial proliferation leading to cancer had lobular rather than ductal origins. (wikipedia.org)
- In a 1922 article in the British Medical Journal Cheatle said that by the time breast cancer became visible it was often too late to be cured by surgery. (wikipedia.org)
- in 2015, Quinn's acoustic EP, a compilation of acoustic tracks from her first two albums, was released on December 8 with proceeds benefitting the Cancer Research Collaboration, an organization formed by Breastlink, where Quinn was treated for invasive ductal carcinoma. (wikipedia.org)
- Raven Quinn finds focus in breast cancer nightmare", USA TODAY, 13 October 2015. (wikipedia.org)
- The official symbol (BRCA1, italic for the gene, nonitalic for the protein) and the official name (breast cancer 1) are maintained by the HGNC. (wikipedia.org)
- its protein, also called by the synonym breast cancer type 1 susceptibility protein, is responsible for repairing DNA. (wikipedia.org)
- If BRCA1 or BRCA2 itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. (wikipedia.org)
- The first evidence for the existence of a gene encoding for a DNA repair enzyme involved in breast cancer susceptibility was provided by Mary-Claire King's laboratory at UC Berkeley in 1990. (wikipedia.org)
- Shortly after her own battle with breast cancer, Corrigan launched Circus of Cancer, a how-to web site for friends and family of women with the disease. (wikipedia.org)
- The website includes a photo album of her own struggle against breast cancer and writings in such categories as "Finding a Lump" and "Losing My Hair. (wikipedia.org)
- A mastectomy is usually carried out to treat breast cancer. (wikipedia.org)
- In some cases, people believed to be at high risk of breast cancer have the operation prophylactically, that is, as a preventive measure. (wikipedia.org)
- Traditionally, in the case of breast cancer, the whole breast was removed. (wikipedia.org)
- men with gynecomastia According to cancer.org, aside from the post-surgical pain and the obvious change in the shape of the breast(s), possible side effects of a mastectomy include wound infection, hematoma (buildup of blood in the wound), and the seroma (buildup of clear fluid in the wound). (wikipedia.org)
- People that are more likely to have the procedure of a simple or total mastectomy are those that have large areas of ductal carcinoma in situ or even those persons that are removing the breast because of the possibility of breast cancer occurring in the future (prophylactic mastectomies). (wikipedia.org)
- When this procedure is done on a cancerous breast, it is sometimes also done on the healthy breast to forestall the appearance of cancer there. (wikipedia.org)
- For healthy people known to be at high risk for breast cancer, this surgery is sometimes done bilaterally (on both breasts) as a cancer-preventive measure. (wikipedia.org)
- This type of mastectomy is used to examine the lymph nodes because this helps to identify whether the cancer cells have spread beyond the breasts. (wikipedia.org)
- It is only recommended for breast cancer that has spread to the chest muscles. (wikipedia.org)
- Visica 2 Treatment System uses cryoablation to treat biopsy proven fibroadenomas and is currently in a Phase 2 clinical trial for the treatment of breast cancer.In 2008, the Visica 2 Treatment System was named a runner-up in the Medical Device category at the Wall Street Journal's Technology Innovation Awards. (wikipedia.org)
- In 2008, the American College of Surgeons Oncology Group chose the Visica 2TM Treatment System as the exclusive ablation treatment technology for a National Cancer Institute funded study to explore the success of cryoablation therapy in the treatment of Invasive Breast Carcinoma. (wikipedia.org)
- Follow-up for the increased risk of breast cancer risk includes monthly breast self-examination, annual breast examination, and mammography at age 30 or five years earlier than the youngest age of breast cancer in the family. (wikipedia.org)
- The magnitude of the risk of breast cancer justifies routine screening with breast MRI as per published guidelines. (wikipedia.org)
- Abnormal expression of glypicans has been noted in multiple types of cancer, including human hepatocellular carcinoma, ovarian cancer, mesothelioma, pancreatic cancer, glioma, breast cancer and recently GCP2 in neuroblastoma. (wikipedia.org)
- It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma). (wikipedia.org)
- MammaPrint is based on the Amsterdam 70-gene breast cancer gene signature and uses formalin-fixed-paraffin-embedded (FFPE) or fresh tissue for microarray analysis. (wikipedia.org)
- The expression profile is then used in a proprietary algorithm to categorically classify the patient as being at either high or low risk of breast cancer recurrence. (wikipedia.org)
- The Netherlands Cancer Institute (NKI) in Amsterdam utilized this information and applied it specifically to breast cancer, creating the Amsterdam 70-gene signature (70-GS). (wikipedia.org)
- A recent study investigated the use of miRNA as a biomarker in pancreatic ductal adenocarcinoma, a form of pancreatic cancer. (wikipedia.org)
- Risk factors for breast cancer may be divided into preventable and non-preventable. (wikipedia.org)
- Breast cancer, like other forms of cancer, can result from multiple environmental and hereditary risk factors. (wikipedia.org)
- For breast cancer, the list of environmental risk factors includes the individual person's development, exposure to microbes, "medical interventions, dietary exposures to nutrients, energy and toxicants, ionizing radiation, and chemicals from industrial and agricultural processes and from consumer products. (wikipedia.org)
- Although many epidemiological risk factors have been identified, the cause of any individual breast cancer is most often unknowable. (wikipedia.org)
- Epidemiological research informs the patterns of breast cancer incidence across certain populations, but not in a given individual. (wikipedia.org)
- The risk of getting breast cancer increases with age. (wikipedia.org)
- A woman is more than 100 times more likely to develop breast cancer in her 60s than in her 20s. (wikipedia.org)
- If all women lived to age 95, about one in eight would be diagnosed with breast cancer at some point during their lives. (wikipedia.org)
- The probability of breast cancer increases with age, but breast cancer tends to be more aggressive in younger people. (wikipedia.org)
- Male individuals have a much lower risk of developing breast cancer than females. (wikipedia.org)
- in a few African countries, which represent the highest incidence of male breast cancer, males account for 5-15% of cases. (wikipedia.org)
- The rate of male breast cancer appears to be rising somewhat. (wikipedia.org)
- Male breast cancer patients tend to be older than female ones. (wikipedia.org)
- United Kingdom being a member of the International Cancer Genome Consortium is leading efforts to map breast cancer's complete genome. (wikipedia.org)
- In 5% of breast cancer cases, there is a strong inherited familial risk. (wikipedia.org)
- Two autosomal dominant genes, BRCA1 and BRCA2, account for most of the cases of familial breast cancer. (wikipedia.org)
- Women who carry a harmful BRCA mutation have a 60% to 80% risk of developing breast cancer in their lifetimes. (wikipedia.org)
- If a mother or a sister was diagnosed breast cancer, the risk of a hereditary BRCA1 or BRCA2 gene mutation is about 2-fold higher than those women without a familial history. (wikipedia.org)
- In addition to the BRCA genes associated with breast cancer, the presence of NBR2, near breast cancer gene 1, has been discovered, and research into its contribution to breast cancer pathogenesis is ongoing. (wikipedia.org)
- Sequence variants of these genes that are relatively common in the population may be associated with a small to moderate increased relative risk for breast cancer. (wikipedia.org)
- However, the suspected impact of most of these variants on breast cancer risk should, in most cases, be confirmed in large populations studies. (wikipedia.org)
- Established by Laureano Simón, PhD, Oncomatryx thus engages twofold in the fight against invasive kinds of cancer, such as pancreatic cancer or invasive breast cancer, all of which have high mortality rates. (wikipedia.org)
- Oncomatryx collaborates with the Institut für Zell Biologie und Immunologie of the University of Stuttgart, the University of Valladolid, Hospital Universitario Marqués de Valdecilla, Hospital Universitario Central de Asturias, the Centro Nacional de Investigaciones Oncológicas, National Jewish Health and Breast Cancer Research among others. (wikipedia.org)
- Bankhead III A, Magnuson NS, Heckendorn RB (2007) Cellular automaton simulation examining progenitor heirarchy structure effects on mammary ductal carcinoma in situ. (springer.com)
- It is believed that atypical ductal hyperplasia (ADH) is a direct precursor for low-grade mammary ductal carcinoma, whereas atypical lobular hyperplasia (ALH) serves as a risk indicator. (wikipedia.org)
- Our aim was to evaluate and compare lymph node involvement, as well as disease-free survival (DFS) and overall survival (OS), between infiltrating ductal carcinoma with (group 1) and without (group 2) intraductal carcinoma component in order to determine the prognostic value of the intraductal component. (springer.com)
- Moriya T, Silverberg SG: Intraductal carcinoma (Ductal carcinoma in situ) of the breast. (springer.com)
- 99% of thetumor volume) (Figure 9) and minor components of poorly differentiated infiltrating ductal carcinoma, not otherwise specified (Elston Score = 8), and high-grade intraductal carcinoma, cribriform-type with apocrine features (Figure 10). (appliedradiology.com)
- Other forms require major surgery, the best known being intraductal carcinoma of the breast (also treated with radiotherapy). (wikipedia.org)
- Analysis of loss of heterozygosity on chromosome 11q13 in atypical ductal hyperplasia and in situ carcinoma of the breast. (springer.com)
- Like the cells of atypical lobular hyperplasia and invasive lobular carcinoma, the abnormal cells of LCIS consist of small cells with oval or round nuclei and small nucleoli detached from each other. (wikipedia.org)
- ADH is characterized by cellular proliferation (hyperplasia) within one or two breast ducts and (histomorphologic) architectural abnormalities, i.e. the cells are arranged in an abnormal or atypical way. (wikipedia.org)
- Atypical hyperplasia is a high-risk premalignant lesion of the breast. (wikipedia.org)
- Also, overexpression of KLF4 in skin resulted in hyperplasia and dysplasia, which lead to the development of squamous cell carcinoma. (wikipedia.org)
- Squamous cell carcinoma Refers to a carcinoma with observable features and characteristics indicative of squamous differentiation (intercellular bridges, keratinization, squamous pearls). (wikipedia.org)
- Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus at least a 10% component of cells characteristic of more highly differentiated types (i.e. adenocarcinoma and/or squamous cell carcinoma). (wikipedia.org)
- Bowen's disease is a squamous carcinoma in situ of the skin. (wikipedia.org)
- However, it also reacts with a range of malignant cells, including those derived from secretory epithelia, but also some squamous carcinomata, such as spindle cell carcinoma. (wikipedia.org)
- The size of the margin is an important issue in areas that are functionally important (i.e. large vessels like the aorta or vital organs), or in areas for which the extent of surgery is minimized due to aesthetic concerns (i.e. melanoma of the face or squamous cell carcinoma of the penis). (wikipedia.org)
- In human glioma cell lines and human squamous cell carcinoma cell line II-4, TGF-β stimulates the expression of MMP7 mRNA and proteins, and facilities the invasive behavior of cells. (wikipedia.org)
- M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
- Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
- Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
- Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
- Microinvasion should be treated with caution, but we could not find any metastatic foci in microinvasive ductal carcinomas (T1mic). (springer.com)
- Left sentinel lymph node excisional biopsy revealed 2 lymph nodes without evidence of local metastatic carcinoma. (appliedradiology.com)
- Metastatic breast carcinoma of the gallbladder. (springermedizin.de)
- Metastatic breast carcinoma presenting as cholecystitis. (springermedizin.de)
- Metastatic breast carcinoma initially presenting as acute cholecystitis: a case report and review of the literature. (springermedizin.de)
- In this study we therefore examined the expression of CXCR4 protein in surgically resected human ductal carcinomas by immunohistochemical staining, and analyzed whether the expression pattern of this chemokine receptor is correlated with metastatic potential and is predictive of clinical outcome in these patients. (biomedcentral.com)
- Prognostic classification of breast ductal carcinoma in situ. (springer.com)
- Owing to the weakness of prognostic information given by cellular, biochemical and molecular features, instead of lymph node status, axillary dissection is still recommended in microinvasive ductal carcinoma in situ. (biomedsearch.com)
- Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ. (medworm.com)
- Invasive ductal carcinoma-no special type, as determined morphologically, is thought to arise exclusively from the luminal epithelial cells of the breast. (aacrjournals.org)
- Accordingly, the MTA3-NuRD complex regulates the expression of Wnt4 in mammary epithelial cells and mice, and controls Wnt4-dependent ductal morphogenesis. (wikipedia.org)
- MMP7 are commonly expressed in epithelial cells including ductal epithelium of exocrine glands in skin, salivary glands, pancreas, glandular epithelium of intestine and reproductive organ, liver, and breast. (wikipedia.org)
- What is the prognosis for invasive ductal carcinoma? (hopkinsmedicine.org)
- Pure mucinous ductal carcinoma carries a better prognosis than more common types of IDCs. (hopkinsmedicine.org)
- Unfortunately, the prognosis for these patients is poor when compared to invasive carcinomas of the breast. (hindawi.com)
- Persistent S100A7 expression in invasive carcinoma is associated with a worse prognosis, and this effect may be mediated in part through interaction with the multifunctional cell signaling protein Jab1. (sigmaaldrich.com)
- Our findings suggest that the expression of VIM and CDH1 can identify a subset of IDCs of the breast with a mesenchymal phenotype associated with poor prognosis, high-grade lesion, and high mitotic index. (scielo.br)
- High-grade carcinomas of the breast showing patterns of mixed ductal and myoepithelial differentiation may show additional morphological features such as foci of metaplasia and appear to have a good prognosis similar to myoepithelial cell-rich carcinomas. (nih.gov)
- OBJECTIVE In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression. (semanticscholar.org)
- Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas. (biomedcentral.com)
- Basal-like carcinomas tend to be more aggressive, with a poor prognosis. (wikipedia.org)
- In urothelial carcinoma, LVI is an independent predictor of a poorer prognosis that has more predictive power than tumour stage. (wikipedia.org)
- In sporadic colorectal carcinoma, LVI of a poorer prognosis. (wikipedia.org)
- Biopsy needle size is a factor associated with upstaging of ductal carcinoma in situ. (greenmedinfo.com)
- The patient returned 3 days later for a stereotactic biopsy of the microcalcifications in the left breast and an ultrasound guided biopsy of the right breast mass. (hindawi.com)
- A biopsy of the ulcer base demonstrated an infiltrating ductal carcinoma. (scielo.org.za)
- Core biopsy of the lesion showed a grade 2 invasive ductal adenocarcinoma. (hindawi.com)
- Sentinel node biopsy in ductal carcinoma in situ of the breast: Never justified? (ovid.com)
- For patients with invasive ductal carcinoma who have lumpectomies, lymph node biopsy and radiation therapy are usually recommended. (wikipedia.org)
- A stereotactic biopsy may be used, with x-ray guidance, for performing a fine needle aspiration for cytology and needle core biopsy to evaluate a breast lesion. (wikipedia.org)
- Stereotactic core biopsy is necessary for evaluating atypical appearing calcifications found on mammogram of the breast. (wikipedia.org)
- Cassi II Rotational Core Biopsy System is a hand-held and self-contained breast biopsy device that utilizes cryotechnology. (wikipedia.org)
- Should patients with ductal carcinoma in situ be treated with adjuvant whole breast radiotherapy after breast conservation surgery? (bmj.com)
- We report a case of a 58-year-old female who developed a primary osteogenic sarcoma of the breast five years after being treated for invasive carcinoma of the ipsilateral breast without the use of radiotherapy. (hindawi.com)
- Postoperatively, patients undergo external beam radiotherapy to the entire breast 5 days a week for 5-6 weeks. (clinicaltrials.gov)
- SweDCIS : Radiotherapy after sector resection for ductal carcinoma in situ of the breast. (diva-portal.org)
- The authors conclude that their findings need to be further validated in other databases before clinicians utilize them for decision-making and future studies should be conducted to identify patients with ductal carcinoma in situ and low-risk who may not benefit from radiotherapy. (oncologynurseadvisor.com)
- Breast conserving surgery (BCS) was performed in 78.6 % of whom 44.0 % received postoperative radiotherapy. (diva-portal.org)
- Ductal carcinoma in situ usually appears on mammography as an area of microcalcification (groups of small calcifications clustered together within the breast). (medifocus.com)
- Ultrasound and mammography revealed a Breast Imaging Reporting and Data System [ 7 ] (BI-RADS) 4 lesion. (hindawi.com)
- It is a multicentric, randomised study including patients from France presenting a unique, limited ( detected by mammography or breast ultrasound. (knowcancer.com)
- It rarely produces symptoms or a breast lump one can feel, and is usually detected through screening mammography. (wikipedia.org)
- In many cases, ductal carcinoma is asymptomatic, and detected as abnormal results on mammography. (wikipedia.org)
- Mammography is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast, which is used as a diagnostic and screening tool. (wikipedia.org)
- Digital breast tomosynthesis (DBT) can provide a higher diagnostic accuracy compared to conventional mammography. (wikipedia.org)
- The primary interest in DBT is in breast imaging, as an extension to mammography, where it offers better detection rates with little extra increase in radiation. (wikipedia.org)
- For example, small, irregular, linear calcifications may be seen, via mammography, in a ductal carcinoma-in-situ to produce visible radio-opacities. (wikipedia.org)
- The pathology revealed grade 2-3 invasive ductal carcinoma of the right breast and ductal carcinoma in situ of the left breast. (hindawi.com)
- Data from 389 cases of infiltrating ductal carcinoma of the breast were included in the study by means of reviewing medical charts and pathology slides. (springer.com)
- Breast pathology. (springer.com)
- Collagenous spherulosis, also mucinous spherulosis and simply spherulosis, is a benign finding in breast pathology. (wikipedia.org)
- A simple mastectomy (removal of the affected breast and often a small part of the underarm lymph nodes). (imaginis.com)
- Pathological examination revealed a T2 N0 M0 grade 1 invasive ductal carcinoma with 14 examined lymph nodes showing no evidence of metastases. (hindawi.com)
- Radical mastectomy involves the removal of the affected breast, the pectoral chest muscles, all chest and underarm lymph nodes, and fat and skin from the chest. (imaginis.com)
- The clinical outcome is generally positive for patients with node-negative breast carcinoma (i.e. those patients without detectable metastases in the lymph nodes) who have been treated with surgery or with surgery and radiation therapy. (biomedcentral.com)
- It is considered useful in identifying microscopic metastases of breast carcinoma in lymph nodes, and in distinguishing Paget's disease from malignant melanoma. (wikipedia.org)
- Stages 1-3 are within the breast or regional lymph nodes. (wikipedia.org)
- The procedure consists in the removal of the breast, the lining over the chest muscles and a part of the lymph nodes from under the arm. (wikipedia.org)
- Radical mastectomy (or "Halsted mastectomy"): First performed in 1882, this procedure involves removing the entire breast, the axillary lymph nodes, and the pectoralis major and minor muscles behind the breast. (wikipedia.org)
- 2,3,7 In contrast, the case reported by Evans et al 4 of infiltrating ductal carcinoma with osseous metaplasia is most analogous to ours, as their patient exhibited similar clinical features. (appliedradiology.com)
- Primary osteogenic sarcoma of the breast is a rare clinical entity with few cases described in the literature. (hindawi.com)
- In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ductal Carcinoma in Situ of the Breast. (medifocus.com)
- These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ductal Carcinoma in Situ of the Breast. (medifocus.com)
- We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast every 3 months. (medifocus.com)
- We performed comparative genomic hybridization (CGH) analysis on 43 grade III invasive ductal breast carcinomas positive for basal cytokeratin 14, as well as 43 grade- and age-matched CK14-negative controls, all with up to 25 years (median, 7 years) of clinical follow-up. (aacrjournals.org)
- Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, Horton J, Hwang S, Johnson PL, Marinovich ML et al (2016) Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in ductal carcinoma in situ. (springermedizin.de)
- To assess the clinical, morphological and immunophenotypic characteristics of breast carcinomas showing patterns of mixed epithelial and myoepithelial differentiation. (nih.gov)
- The reports of 4,271 breast MRIs from eight large scale clinical trials were reviewed in 2006. (wikipedia.org)
- In May 2016, Dr. Quay and Dr. Shu-Chih Chen, Ph.D. had published the book, "Nipple Aspirate Fluid Exfoliative Cytopathology and Molecular Biomarkers: Current Role in the Management of Breast Health," which describes the status of research and clinical practice involving the Atossa technology. (wikipedia.org)
- 2,3,5,7 This case of infiltrating ductal carcinoma with osseous metaplasia is unusual enough to not be definitely identified in any of these larger series. (appliedradiology.com)
- Expression of fibrinogen E-fragment and fibrin E-fragment is inhibited in the human infiltrating ductal carcinoma of the breast: the two-dimensional electrophoresis and MALDI-TOF-mass spectrometry analyses," International Journal of Oncology , vol. 27, no. 5, pp. 1425-1431, 2005. (hindawi.com)
- No evidence of infiltrating ductal carcinoma or ductal carcinoma in situ was observed. (hindawi.com)
- As in females, infiltrating ductal carcinoma is the most common type. (wikipedia.org)
- Infiltrating basal cell carcinoma, non-sclerosing Infiltrating basal cell carcinoma, sclerosing Basal cell carcinoma, morpheic Basal cell carcinoma, desmoplastic type M8093/3 Basal cell carcinoma, fibroepithelial (C44. (wikipedia.org)
- Tresserra F, Grasses PJ, Garrido M. Lesiones hiperplásicas y preinvasivas precursoras del cáncer de mama: desde la epiteliosis hasta la neoplasia ductal intraepitelial. (springer.com)
- The role of synthetic androgens in the development of male breast neoplasia warrants further scrutiny. (uzh.ch)
- Lobular carcinoma in situ is a form of in situ neoplasia that develops within the terminal lobules of the breast. (jcancer.org)
- Patients then undergo multifunctional MRI (including dynamic contrast-enhancement MRI and diffusion-weighted MRI) of the ipsilateral breast in the prone position (≥ 3 weeks after surgery). (clinicaltrials.gov)
- Five years after her surgery, the patient presented with a painless, mobile, 15 cm mass involving the upper and lower outer quadrants of the left breast. (hindawi.com)
- Lumpectomy is attractive to many women because it allows them to maintain most of their breast after surgery. (imaginis.com)
- For both groups, preoperative MRI use was higher for women treated with mastectomy than with breast-conserving surgery. (ahrq.gov)
- All patients were treated with breast-conserving surgery between 1998 and 2007 and were followed for a median of 91 months. (oncologynurseadvisor.com)
- Surgery may be either a breast-conserving lumpectomy or a mastectomy (complete or partial removal of the affected breast). (wikipedia.org)
- Types of surgery vary from breast-conserving surgery to mastectomy. (wikipedia.org)
- Breast reconstruction may take place at the time of surgery or at a later date. (wikipedia.org)
- Additionally, mammograms should not be done with any increased frequency in people undergoing breast surgery, including breast enlargement, mastopexy, and breast reducation. (wikipedia.org)
- even in patients after ductal carcinoma in situ surgery. (wikipedia.org)
- Ductal" means "related to the milk ducts " and "in situ" means "in place. (komen.org)
- Treatment of mastitis and/or abscess in nonlactating women largely the same as that of lactational mastitis, generally involving antibiotics treatment, possibly surgical intervention by means of fine-needle aspiration and/or incision and drainage and/or interventions on the lactiferous ducts (for details, see also the articles on treatment of mastitis, of breast abscess and of subareolar abscess). (wikipedia.org)
- The majority of breast diseases either originate from lactiferous ducts or are closely related. (wikipedia.org)
- Auto-amputation of a breast as the result of a malignant process has been reported twice. (scielo.org.za)
- 1. Kuten A, Cohen Y, Kerner V. Malignant melanoma of the nipple with auto-amputation of the breast. (scielo.org.za)
- Carcinomas occur when the DNA of a cell is damaged or altered and the cell begins to grow uncontrollably and become malignant. (wikipedia.org)
- There is some controversy as to whether these cells arise from the ductal system of the breast, or whether these cells are a result of in situ malignant transformation. (wikipedia.org)
- Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
- Cylindrical cell carcinoma M8122/3 Transitional cell carcinoma, spindle cell Transitional cell carcinoma, sarcomatoid M8123/3 Basaloid carcinoma M8124/3 Cloacogenic carcinoma (C21.2) M8130/1 Papillary transitional cell neoplasm of low malignant potential (C67. (wikipedia.org)
- Papillary urothelial neoplasm of low malignant potential M8130/2 Papillary transitional cell carcinoma, non-invasive (C67. (wikipedia.org)
- We feel that a study of AR CAG repeats in benign apocrine metaplasia, which is always immunohistochemically positive for AR, 5 together with and without cases of apocrine and/or non-apocrine in situ and invasive breast carcinoma, would be very valuable in highlighting the importance of CAG repeats and apocrine differentiation. (bmj.com)
- There is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands. (wikipedia.org)
- A nipple adenoma is a rare benign tumour of the breast. (wikipedia.org)
- Axillary lymph node involvement was found in 3 cases (i.e. 5%) which harbored poor histologic features: comedocarcinoma subtype, high nuclear grade, and size of the ductal carcinoma in situ greater than 3 cm, requiring total mastectomy. (biomedsearch.com)
- Chou S-H.S., Gombos E.C., Chikarmane S.A., Giess C.S., Jayender J. Computer-Aided Heterogeneity Analysis in Breast MR Imaging Assessment of Ductal Carcinoma In Situ: Correlating Histologic Grade and Receptor Status . (harvard.edu)
- Their histologic appearance is similar to ductal breast carcinoma. (wikipedia.org)
- The histologic patterns include: Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003. (wikipedia.org)
- Molecular genetic markers to identify the 13% lymph node-negative mammary carcinomas that are prone to develop metastases would clearly be of considerable value in indicating those cases in need of early aggressive therapy. (biomedcentral.com)
- There are various patterns of prevalence of genetic mutations in the genomes of primary breast tumour and its metastases. (wikipedia.org)