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CarcinomaAdipose Tissue, BrownCarcinoma, Squamous CellCarcinoma, HepatocellularAdipocytes, BrownCarcinoma in SituCarcinoma, PapillaryLiver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellImmunohistochemistryCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellPhaeophytaTumor Markers, BiologicalCarcinoma, MedullaryAdenocarcinomaCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessCell Line, TumorNasopharyngeal NeoplasmsPrognosisThyroid NeoplasmsBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsRats, Inbred BNCarcinoma, EmbryonalThermogenesisEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsColonic NeoplasmsAdrenocortical CarcinomaCarcinoma, VerrucousRNA, MessengerCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsSkin NeoplasmsNeoplasm ProteinsStomach NeoplasmsNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellDNA, NeoplasmAntineoplastic AgentsRetrospective StudiesImmunoenzyme TechniquesLaryngeal NeoplasmsUterine Cervical NeoplasmsReverse Transcriptase Polymerase Chain ReactionNeoplasm TransplantationNeoplasms, Multiple PrimarySurvival RateAdenocarcinoma, FollicularSurvival AnalysisTreatment OutcomeMitochondrial ProteinsAdenocarcinoma, MucinousAntigens, NeoplasmEmbryonal Carcinoma Stem CellsPrecancerous ConditionsCarcinoma, Papillary, FollicularGallbladder NeoplasmsTime FactorsCarcinoma, Non-Small-Cell LungTumor Suppressor Protein p53Cell ProliferationEndometrial NeoplasmsApoptosisAdenocarcinoma, Clear CellDisease ProgressionColorectal Neoplasmsalpha-FetoproteinsTongue NeoplasmsCold TemperatureBase SequenceCell DivisionPancreatic NeoplasmsCystadenocarcinoma, SerousCarcinoma, Lewis LungMolecular Sequence DataCombined Modality TherapyMutationBronchial NeoplasmsSalivary Gland NeoplasmsTissue Array AnalysisBlotting, WesternDisease-Free SurvivalKeratinsCisplatinFollow-Up StudiesTomography, X-Ray ComputedRNA, NeoplasmCell Transformation, NeoplasticBrown Recluse SpiderFatal OutcomeBiopsyAntibodies, MonoclonalTransplantation, HeterologousKi-67 AntigenGenes, p53TroutAdenocarcinoma, PapillaryGene ExpressionAdipose Tissue, WhiteGene Expression ProfilingBody Temperature RegulationChemoembolization, TherapeuticIon ChannelsLoss of HeterozygosityMammary Neoplasms, ExperimentalKaplan-Meier EstimateCarrier ProteinsSignal TransductionMembrane ProteinsAdipocytes, WhiteCell DifferentiationNeovascularization, PathologicCarcinoma, BasosquamousTranscription FactorsReceptor, erbB-2Sensitivity and SpecificityThyroidectomyCarcinoembryonic AntigenAntineoplastic Combined Chemotherapy ProtocolsGenes, Tumor SuppressorNeoplasms, ExperimentalTransfectionBreastCell LineDown-RegulationCadherinsPapillomaviridaeRectal NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarSargassumHyperplasiaTumor Suppressor ProteinsUp-RegulationLiver Neoplasms, ExperimentalCarcinoma, Pancreatic DuctalLiver CirrhosisPhenotypeAdrenal Cortex NeoplasmsUrotheliumVulvar NeoplasmsSeaweedCase-Control StudiesFucusHaresOropharyngeal NeoplasmsReceptor, Epidermal Growth FactorReceptors, EstrogenPapillomaRisk FactorsTumor BurdenFluorouracilMicrosatellite RepeatsPromoter Regions, GeneticDNA-Binding ProteinsLymph NodesCell SurvivalPhenylurea CompoundsLiverXenograft Model Antitumor AssaysIn Situ Hybridization, FluorescenceNeoplasm GradingMice, Inbred BALB CBile Duct NeoplasmsCarcinoma, Giant CellUrologic NeoplasmsDose-Response Relationship, DrugNiacinamideProto-Oncogene ProteinsGene AmplificationDNA Mutational AnalysisOligonucleotide Array Sequence AnalysisKeratin-7DNA PrimersBenzenesulfonatesUreteral NeoplasmsIn Situ HybridizationHepatectomyNeoplasmsCarcinoma, Ehrlich TumorNuclear Proteins
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Adipose Tissue, Brown: A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Adipocytes, Brown: Fat cells with dark coloration due to the densely packed MITOCHONDRIA. They contain numerous small lipid droplets or vacuoles. Their stored lipids can be converted directly to energy as heat by the mitochondria.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Phaeophyta: A division of predominantly marine EUKARYOTA, commonly known as brown algae, having CHROMATOPHORES containing carotenoid PIGMENTS, BIOLOGICAL. ALGINATES and phlorotannins occur widely in all major orders. They are considered the most highly evolved algae because of their well-developed multicellular organization and structural complexity.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Cell Line, Tumor: A cell line derived from cultured tumor cells.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Breast Neoplasms: Tumors or cancer of the human BREAST.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Rats, Inbred BNCarcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Thermogenesis: The generation of heat in order to maintain body temperature. The uncoupled oxidation of fatty acids contained within brown adipose tissue and SHIVERING are examples of thermogenesis in MAMMALS.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Mouth Neoplasms: Tumors or cancer of the MOUTH.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Colonic Neoplasms: Tumors or cancer of the COLON.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Stomach Neoplasms: Tumors or cancer of the STOMACH.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)DNA, Neoplasm: DNA present in neoplastic tissue.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Mitochondrial Proteins: Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Tongue Neoplasms: Tumors or cancer of the TONGUE.Cold Temperature: An absence of warmth or heat or a temperature notably below an accustomed norm.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.RNA, Neoplasm: RNA present in neoplastic tissue.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Brown Recluse Spider: A spider of the genus Loxosceles, found in the midwestern and other parts of the United States, which carries a hemolytic venom that produces local necrosis or ulceration.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Transplantation, Heterologous: Transplantation between animals of different species.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Trout: Various fish of the family SALMONIDAE, usually smaller than salmon. They are mostly restricted to cool clear freshwater. Some are anadromous. They are highly regarded for their handsome colors, rich well-flavored flesh, and gameness as an angling fish. The genera Salvelinus, Salmo, and ONCORHYNCHUS have been introduced virtually throughout the world.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Adipose Tissue, White: Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Body Temperature Regulation: The processes of heating and cooling that an organism uses to control its temperature.Chemoembolization, Therapeutic: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Adipocytes, White: Fat cells with light coloration and few MITOCHONDRIA. They contain a scant ring of CYTOPLASM surrounding a single large lipid droplet or vacuole.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Rectal Neoplasms: Tumors or cancer of the RECTUM.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Sargassum: One of the largest genera of BROWN ALGAE, comprised of more than 150 species found in tropical, subtropical, and temperate zones of both hemispheres. Some species are attached (benthic) but most float in the open sea (pelagic). Sargassum provides a critical habitat for hundreds of species of FISHES; TURTLES; and INVERTEBRATES.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Urothelium: The epithelial lining of the URINARY TRACT.Vulvar Neoplasms: Tumors or cancer of the VULVA.Seaweed: Multicellular marine macroalgae including some members of red (RHODOPHYTA), green (CHLOROPHYTA), and brown (PHAEOPHYTA) algae. They are widely distributed in the ocean, occurring from the tide level to considerable depths, free-floating (planktonic) or anchored to the substratum (benthic). They lack a specialized vascular system but take up fluids, nutrients, and gases directly from the water. They contain CHLOROPHYLL and are photosynthetic, but some also contain other light-absorbing pigments. Many are of economic importance as FOOD, fertilizer, AGAR, potash, or source of IODINE.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Fucus: A genus of BROWN ALGAE in the family Fucaceae. It is found in temperate, marine intertidal areas along rocky coasts and is a source of ALGINATES. Some species of Fucus are referred to as KELP.Hares: The genus Lepus, in the family Leporidae, order LAGOMORPHA. Hares are born above ground, fully furred, and with their eyes and ears open. In contrast with RABBITS, hares have 24 chromosome pairs.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Mice, Inbred BALB CBile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Carcinoma, Giant Cell: An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Niacinamide: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Benzenesulfonates: Organic salts and esters of benzenesulfonic acid.Ureteral Neoplasms: Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

Experimental intraocular malignancy: the effect of intracameral perfusion. (1/4)

Transplantable Brown-Pearce carcinoma was adapted successfully in the rabbit anterior chamber. Regression of tumor growth was attained on tri-weekly perfusion of the AC with 10 micromolar of methotrexate. Tumor cyclic nucleotide phosphodiesterase (PDE) and protein activator were found to be markedly depressed during the course of chemotherapy and the PDE cAMP/cGMP ratio was similarly altered. Corroborative light and electron-microscopic studies showed specific alterations of intracellular organelles in relation to MTX and tumor cell death. These findings suggest that metabolic pathways of cyclic nucleotides are important biochemical modulators of neoplastic cells. The method of intraocular perfusion precludes systemic toxic effects and avoids compromising the animals' immunocompetence.  (+info)

Sustained release of BCNU for the treatment of intraocular malignancies in animal models. (2/4)

Sustained release of 1,3-bis(2)chloroethyl)-1-nitrosourea (BCNU) via an episcleral implanted silicone device was used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. One group of test eyes received BCNU dissolved in sesame oil; a second group received BCNU in pure ethanol. Control eyes received only the diluent, sesame oil or pure ethanol. The effectiveness of the various dosages and diluents was compared by clinical observation, by weight of the enucleated eyes, and by histopathologic examination. Sustained release of BCNU via an episcleral implanted silicone device delayed the growth of Brown-Pearce epithelioma in rabbit eyes of both test groups. The most effective action resulted from administration of BCNU in pure ethanol.  (+info)

Tumor dormancy in vivo by prevention of neovascularization. (3/4)

Dormant solid tumors were produced in vivo by prevention of neovascularization. When small fragments of anaplastic Brown-Pearce carcinoma were implanted directly on the iris in susceptible rabbits, they always vascularized. A characteristic growth pattern, consisting of prevascular, vascular, and late phases, was observed, which terminated with destruction of the eye within 2 wk. The beginning of exponential volume increase was shown to coincide with vascularization of the implant, as demonstrated by perfusion with intravenous fluorescein and by histologic sections. In contrast, implants placed in the anterior chamber, at a distance from the iris, did not become vascularized. After initial growth into spheroids, they remained arrested at a small size comparable to prevascular iris implants, for periods as long as 6 wk. Although dormant in terms of expansion, these avascular tumors contained a population of viable and mitotically active tumor cells. When reimplanted on the iris, vascularization was followed by rapid, invasive growth. These observations suggest that neovascularization is a necessary condition for malignant growth of a solid tumor. When a small mass of tumor cells is prevented from eliciting new vessel ingrowth from surrounding host tissues, population dormancy results. These data suggest that the specific blockade of tumor-induced angiogenesis may be an effective means of controlling neoplastic growth.  (+info)

Direct delivery of anticancer agents: experimental treatment of intraocular malignancy. (4/4)

Two anticancer agents, one lipophilic, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and one hydrophilic, 5-(3,3-dimethyl-1-triazeno) imidazol-4-carboxamide (DTIC), were used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. The BCNU test animals were divided into three groups: one treated by direct injection of the drug into the subconjuntival space or the anterior chamber, the second by both direct injections and intravenous administration, and the third by intravenous injection alone. The DTIC test animals were treated with only local injection into the subconjunctival space or anterior chamber. Dosage, delivery system, and effectiveness were compared following clinical observation and histopathologic examination. Direct delivery of BCNU or DTIC in subconjuntival space or anterior chamber delayed the growth of Brown-Pearce epithelioma in rabbit eye. The effectiveness of this treatment was significnatly enhanced by combining direct injection with systemic administration of a lower dose of BCNU.  (+info)

INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR | JEMINCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR | JEM
A detailed study has been made of an antibody which appears in the blood of certain rabbits implanted with the Brown-Pearce carcinoma or injected with extracts of it and which reacts specifically in vitro in mixture with a distinctive sedimentable constituent of the Brown-Pearce tumor cell. The observations as a whole seem to indicate that this constituent of the Brown-Pearce tumor differs notably from certain other sedimentable substances which can be extracted from various rabbit tissues and identified by serological means. The implications of the findings are discussed.. ...
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The action of the guanine analog, 5-amino-7-hydroxy-1H-v-triazolo (d) pyrimidine, on a variety of experimental tumors has been reported. Three transplantable adenocarcinomas of the breast in mice (755, RC, and Eo771) were effectively inhibited by the chemical agent, whether therapy was instituted shortly after transplantation or after the tumor had become well established; anterior chamber transplants of an undifferentiated squamous-cell carcinoma (Brown-Pearce) in rabbits eyes were similarly controlled by the triazolopyrimidine. No demonstrable inhibitory effects of the chemical on an undifferentiated sarcoma (Sarcoma 180) could be detected, nor was there any apparent inhibition of an acute leukemia (9417) or lymphosarcoma (6C3HED) in preliminary experiments, with the dosage employed.. Using the changes in body weight during therapy as an over-all index of toxicity of the triazolopyrimidine, it was observed that the therapeutic activity of the drug against the tumors was not associated with ...
Browse Stanford ChEM-H | Stanford ProfilesBrowse Stanford ChEM-H | Stanford Profiles
My group is very interested in how to design new inorganic structures that will seamless integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include "nanostraw" drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to fuse into the cell wall, providing a tight electrical junction for solid-state patch clamping. ...
Browse School of Engineering | Stanford ProfilesBrowse School of Engineering | Stanford Profiles
My group is very interested in how to design new inorganic structures that will seamless integrate with biological systems to address problems that are not feasible by other means. This involves both fundamental work such as to deeply understand how lipid membranes interact with inorganic surfaces, electrokinetic phenomena in biologically relevant solutions, and applying this knowledge into new device designs. Examples of this include "nanostraw" drug delivery platforms for direct delivery or extraction of material through the cell wall using a biomimetic gap-junction made using nanoscale semiconductor processing techniques. We also engineer materials and structures for neural interfaces and electronics pertinent to highly parallel data acquisition and recording. For instance, we have created inorganic electrodes that mimic the hydrophobic banding of natural transmembrane proteins, allowing them to fuse into the cell wall, providing a tight electrical junction for solid-state patch clamping. ...
Recent Articles | Techniques, Immunology And Developmental Biology | The Scientist Magazine®| Page 28Recent Articles | Techniques, Immunology And Developmental Biology | The Scientist Magazine®| Page 28
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
Recent Articles | Cannabis And Immunology | The Scientist Magazine®| Page 12Recent Articles | Cannabis And Immunology | The Scientist Magazine®| Page 12
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
Premium Boar Semen : Birchwood Advanced Genetic Solutions :: Management TeamPremium Boar Semen : Birchwood Advanced Genetic Solutions :: Management Team
Jamie oversees the daily production and distribution of semen and supplies from all three Birchwood sites. He works closely with the Lab Managers, Sire Technician Managers and the Direct Delivery team to optimize labor efficiency, application of technologies, distribution logistics, genetic upgrades, and herd biosecurity, all in an effort to provide customers with the strongest-performing products available, delivered in a timely fashion.. ...
Mom It Down! Toasted Almond Angel Food Cake | MihowMom It Down! Toasted Almond Angel Food Cake | Mihow
This summertime treat is so light and fluffy, its the perfect substitute for cake on a hot summer day. Not only does it taste awesome, but your home will smell like a pancake house. (True story: while this was in the oven on Saturday, our Fresh Direct delivery showed up and the two guys would…
Abstracts - The Fischell FestivalAbstracts - The Fischell Festival
Dr. Christopher Jewell, Assistant Professor, Fischell Department of Bioengineering, University of Maryland. Vaccines and immunotherapies have generated some of the largest impacts on human health in history, but a fundamental challenge now facing the field is how to control specific properties of immune responses elicited by vaccines. This seminar will introduce two strategies being developed to study and exploit the interactions between biomaterials and immune cells and tissues. One approach involves direct delivery of synthetic vaccine carriers to lymph nodes, the command center that coordinate immune response. We have combined direct lymph node injection-which has recently demonstrated great potential in human clinical trials-with biomaterials to establish a platform to directly study the link between material properties and lymph node function. We have also adapted this idea to locally engineer the lymph node environment to generate rapid and potent immune responses. To better control the ...
Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium-Dependent Manner - Savina - 2004 - Traffic - Wiley...Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium-Dependent Manner - Savina - 2004 - Traffic - Wiley...
Ren M, Xu G, Zeng J, Lemos-Chiarandini C, Adesnik M, Sabatini DD. Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci U S A 1998;95: 6187-6192.DOI: 10.1073/pnas.95.11.6187 ...
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Premium Boar Semen : Birchwood Advanced Genetic Solutions :: Quality ValuesPremium Boar Semen : Birchwood Advanced Genetic Solutions :: Quality Values
Facilitating customer success is what Birchwood strives to achieve. In addition to featuring PIC genetics, which are the leading swine genetics in the world, great care is taken to process a product utilizing the most accurate evaluation technologies, engage independent laboratories for third-party verification, and manage and deliver the product with optimal care.. From the moment the sires are received, aggressive health testing and monitoring is performed under the watchful direction of the PIC Health Assurance Veterinarian Team.. Collection and processing of boar semen is performed in state-of-the-art facilities, utilizing the latest instruments and technologies, thus providing consistent product quality control.. Delivery of our products is performed with utmost concern with regard to temperature maintenance. Whether the product is delivered with our own same-day courier service called Direct Delivery®, our AirDirect™ airline delivery program, or with commercial overnight delivery ...
Clinical Trials Registry | Internet Stroke CenterClinical Trials Registry | Internet Stroke Center
Stroke is the second leading cause of death and the leading cause of adult disability worldwide. This investigation will address the safety and feasibility of directed, intra-arterial Magnesium measurement and therapy, through endovascular access, in acute stroke patients. The proposal represents the first study to directly quantify levels of a systemically administered neuroprotectant in the region of cerebral ischemia. It also establishes a novel endovascular platform for direct delivery of neuroprotective agents to ischemic cerebral tissue distal to an occlusive thrombus. This research seeks to improve patient care by establishing a novel delivery mechanism for the rescue of threatened brain parenchyma that can be administered rapidly following acute stroke. If successful, this selective distribution will allow delivery to "at risk" tissue in a rapid manner. Salvage of viable, but threatened, penumbral tissue could afford stroke patients an increased probability of favorable long term ...
Potassium IodidePotassium Iodide
The Potassium (KI) pill:. ATHF3, with cosponsors, Beyond Nuclear beyondnuclear.org, Nuclear Information and Resource Service NIRS.org and Citizens Resistance at Fermi 2, has begun a project of going door to door to every household within a 10 mile radius of Fermi 2 to gather support and signatures for direct delivery of potassium iodide (KI) pills to every household and business within the 10 mile radius. The NRC recognizes the KI pill as part of emergency planning but leaves implementation up to the states with federal government covering cost. Only 5.3 % of those within a 10 mile radius of Fermi 2 have used a voucher to obtain the pill. This is in large part because the NRC and DTE Energy dismiss the risk as small and not needing mitigation.. Pregnant women and children are at the highest risk of thyroid cancer and other thyroid related illnesses from a release of radioactive iodine 131. If immediately informed of such a release and the pill is taken, it will block absorption of radioactive ...
Identification of Target Structures for New Vaccines Specifically Directed at Dendritic CellsIdentification of Target Structures for New Vaccines Specifically Directed at Dendritic Cells
Dendritic cells (DCs) are superior antigen presenting cells (APCs) that are important for the initiation adaptive of immune responses. They are uniquely equipped for the activation and expansion of both naïve and memory T cells. In fact, studies have shown that direct delivery of antigens (Ags) to DCs may augment both T cell responses and humoral immunity. For this purpose, DCs express a unique pattern of cell surface receptors that can be employed as target structures for such targeted delivery of Ags to DCs. Different surface receptors on DCs will, to a varying extent, lead to internalization, processing and presentation of the Ag to T cells. Depending on the intracellular routing of the Ag, antigenic peptides are presented on MHC class I and/ or class II facilitating induction of different T cell responses. A number of different target receptors have been assayed for this purpose, but several other DC surface molecules deserve examination for their usefulness for Agdelivery. Antibodies ...
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Most preclinical and clinical testing of GDNF and its family member NTN has focused on direct delivery of high concentrations of recombinant protein or viral vector-based cDNA overexpression. However, there is evidence suggesting that supraphysiological levels of GDNF maintained long term may not be the best method of providing trophic support for dopaminergic neurons in vivo. For example, chronic putamenal infusion of recombinant GDNF caused reduced food consumption and body weight, as well as Purkinje cell loss in rhesus monkeys (Hovland et al., 2007); overexpression of GDNF cDNA in the substantia nigra led to severe weight loss in rodents (Manfredsson et al., 2009a,b) and monkeys (Su et al., 2009).. Our study demonstrates an alternative means of augmenting GDNF expression that produces more physiologically relevant levels of GDNF. Engineered ZFP TFs drive significant activation of the endogenous GDNF gene in multiple cell types. The relative extent of activation was inversely correlated with ...
Most recent papers with the keyword liver progenitor cell | Read by QxMDMost recent papers with the keyword liver progenitor cell | Read by QxMD
The paucity of liver donation highlights the use of cell-based strategies for end-stage liver failure. We recently showed that bone marrow-derived aggregates (BMDAs) can completely restore the hematopoietic system in gamma-irradiated mice. These aggregates are stem and progenitor cells in the bone marrow (BM), composed of both hematopoietic and non-hematopoietic lineages. Furthermore, reports showed that resident BM cells migrate to the liver and integrate themselves into the tissue in small numbers. Hence, we hypothesized that direct delivery of BMDAs to the damaged liver might enhance the integration of BM cells in the liver because of its stemness property, intact BM architecture, the physical proximity of these niche-like structures to the damaged sites and the existence of liver paracrine factors ...
A Star Research 1 - Prof. G.J. Vancso - University Twente - NetherlandsA Star Research 1 - Prof. G.J. Vancso - University Twente - Netherlands
Direct delivery of therapeutic compounds to cellular targets can enhance drug efficacy and safety, but such techniques require careful monitoring within the body. Now, a research team led by Julius Vancso at the A*STAR Institute of Materials Research and Engineering in Singapore has developed polymer microspheres labeled with fluorescent quantum dots that promise to light up the pathways of critical biological processes1.. Scientists often attach fluorescent markers, such as chemical dyes, to biomolecules to track their movements inside living cells. Quantum dots-semiconductor nanocrystals with extraordinary light-emitting capabilities-promise to radically advance biological imaging by offering a brighter, longer-lived source of fluorescent light than any comparable dye. Incorporating quantum dots (QDs) into living systems is challenging, however, because the long, hydrophobic carbon chains typically present on the surfaces of QDs make the dots insoluble in water.. ...
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USA: NBCi and Dominos Pizza deliver free nationwide internet access service | Food Industry News | just-foodUSA: NBCi and Dominos Pizza deliver free nationwide internet access service | Food Industry News | just-food
NBC Internet, Inc. (Nasdaq: NBCI), a leading Internet portal company that brokers information, commercial, and entertainment transactions, yesterday announced a strategic distribution agreement with Dominos Pizza, the recognized world leader in pizza delivery, to offer Dominos pizza-eaters a free nationwide Internet access service through an agreement with myfavoritei.The new co-branded NBCi.com/Dominos free Internet access service will be distributed and marketed by Dominos through a variety of offline and online mechanisms -- including direct delivery of CD-ROMs affixed to Dominos pizza delivery boxes in select markets; in marketing messages that have been printed on Dominos pizza boxtoppers; in Dominos newspaper advertising inserts; and within Dominos doorhanger materials.The co-branded free ISP also is available immediately for download at related to Multichannel,
South Carolina Legislature Online - Amendment HistorySouth Carolina Legislature Online - Amendment History
B) County boards may apply to the department for funds for community services development under the terms and conditions as may be prescribed by the department. The department shall review the applications and, subject to state appropriations to the department or to other funds under the departments control, may fund the programs it considers in the best interest of service delivery to the citizens of the State with intellectual disability, related disabilities, autism spectrum disorder, head injuries, or spinal cord injuries. SECTION 15. Section 44-20-385(5) and (8) of the 1976 Code, as last amended by Act 47 of 2011, is further amended to read: (5) shall employ personnel and expend its budget for the direct delivery of services or contract with those service vendors necessary to carry out the county intellectual disability, related disabilities, autism spectrum disorder, head injuries, and spinal cord injuries services program who meet specifications prescribed by the department; (8) shall ...
Epithelioma of the small intestine in a 3 year old child; acute invagination]. - Semantic ScholarEpithelioma of the small intestine in a 3 year old child; acute invagination]. - Semantic Scholar
Semantic Scholar extracted view of [Epithelioma of the small intestine in a 3 year old child; acute invagination]. by Allen Russell Chauvenet et al.
What are the non-intravenous routes for Benzodiazepines in epilepsy?What are the non-intravenous routes for Benzodiazepines in epilepsy?
Several alternative routes are currently being explored. This is a narrative review of data about delivery methods for benzodiazepines alternative to the intravenous and oral routes for the acute treatment of seizures. Unconventional delivery options such as direct delivery to the central nervous system or inhalers are reported. Data show that intranasal diazepam or midazolam and the intramuscular auto-injector for midazolam are as effective as rectal or intravenous diazepam. Head-to-head comparisons with buccal midazolam are urgently needed. In addition, the majority of trials focused on children and adolescents, and further trials in adults are warranted.. Reference:. Mula, M. (2016) New Non-Intravenous Routes for Benzodiazepines in Epilepsy: A Clinician Perspective. CNS Drugs. December 9th. [Epub ahead of print].. DOI: 10.1007/s40263-016-0398-4. Thank you to our partners for supporting IVTEAM ...
AAV2-GDNF for Advanced Parkinson s Disease - Full Text View - ClinicalTrials.govAAV2-GDNF for Advanced Parkinson s Disease - Full Text View - ClinicalTrials.gov
Objective:. While medications can temporarily alleviate the symptoms of Parkinson s disease (PD), they do not influence the degenerative process. Progressive loss of nigral dopaminergic (DA) neurons (the pathological hallmark of PD) results in progressive neurologic dysfunction and death. Glial cell line-derived neurotrophic factor (GDNF) was first identified based on its ability to promote the survival of embryonic DA neurons in vitro, and research has demonstrated beneficial effects of GDNF in animal models of PD. Preliminary clinical trials of GDNF infusions have yielded inconclusive results. Observed problems with tolerability and efficacy in these studies may have been related to the methods of delivery. Recent evidence indicates that gene transfer via direct delivery of viral vectors may represent a superior approach for the treatment of PD with GDNF.. Study population:. Twenty-four adult male and female subjects with advanced Parkinson s disease, who are candidates for surgical treatment ...
Ophthalmology | Upstate Cancer Center | SUNY Upstate Medical UniversityOphthalmology | Upstate Cancer Center | SUNY Upstate Medical University
Retinoblastomas, intraocular malignancies of childhood, can also be directly visualized within the eye during examination. With early detection, the cure rate for this tumor is excellent. More is known about the genetic basis for cancer in retinoblastoma than in any other human tumor. The exact chromosome location and DNA sequence alterations that cause this tumor can now be characterized. This has been immensely helpful in establishing patient prognosis and in genetic counseling of family members ...
Retinoblastoma: Treatment and outcomeRetinoblastoma: Treatment and outcome
Retinoblastoma is the most common primary intraocular malignancy of childhood and accounts for 10 to 15 percent of cancers within the first year of life. Retinoblastoma typically presents as leukocoria () in a child under the age of two years. Untrea
Malignant Choroidal MelanomaMalignant Choroidal Melanoma
... (MCM) is a rare diagnosis, although it is the most commonly reported intraocular malignancy. Furthermore, the choroid is the second most common site that melanomas occur.…Malignant Choroidal Melanoma: Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Epithelioma cuniculatum definition | Drugs.comEpithelioma cuniculatum definition | Drugs.com
Definition of epithelioma cuniculatum. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Health: Hearsay and Headlines: Epilepsy Organizations Award Grants for New Gene Therapy to Treat Epilepsy and Novel Surgical...Health: Hearsay and Headlines: Epilepsy Organizations Award Grants for New Gene Therapy to Treat Epilepsy and Novel Surgical...
Scott McPhee, Ph.D., Vice President of Clinical Development, Asklepios BioPharmaceutical Inc., and Nicholas Boulis, M.D., Assistant Professor, Neurosurgery, Emory University, will be conducting preclinical studies of a Galanin gene delivery for selected patients with uncontrolled Mesial Temporal Lobe Epilepsy (MTLE). Direct delivery of a gene therapy to the temporal lobe offers the significant potential of a less invasive, more effective alternative approach that precludes the trauma and resulting complications of surgical tissue removal, and avoids the side effects of standard pharmacological treatments. The protein galanin has been shown to suppress seizures. Gene delivery of galanin DNA has been shown to have anticonvulsant and neuroprotective effects in models of MTLE. Unlike traditional anti-epileptic medications, galanin gene delivery may be administered in a one-time intervention that provides long-term supplemental galanin in the epileptogenic tissue. The proposed therapeutic approach ...
Epithelioma and rodent ulcer, illustration - Stock Image C030/8491 - Science Photo LibraryEpithelioma and rodent ulcer, illustration - Stock Image C030/8491 - Science Photo Library
Cases of extensive epithelioma (left) and rodent ulcer (right), historical medical illustration. Epithelioma is an abnormal growth of the epithelium, a layer of tissue that covers the surfaces of organs and other parts of the body. It may be benign or malignant. A rodent ulcer (basal cell carcinoma) is a common form of skin cancer, and is most often caused by over-exposure to sunlight. From Atlas of Venereal and Skin Diseases by Prince Albert Morrow, published in 1889. - Stock Image C030/8491
Uveal melanoma in England: Trends over time and geographical variation - Nuffield Department of Population HealthUveal melanoma in England: Trends over time and geographical variation - Nuffield Department of Population Health
Aims: Uveal melanoma is the commonest primary intraocular malignancy in adults, and leads to death in approximately half of patients. The Aim: was to report on trends over time and geographical variation in rates of uveal melanoma in England. Method:s Analysis of admissions for uveal melanoma, using linked English national hospital episode statistics, available from 1999 to 2010, and the Oxford record linkage study (ORLS), before that, from 1979 to 1998. Results: The annual rate of people admitted in England with a new record of uveal melanoma remained stable at approximately 1.0 people per 100 000 population from 1999 to 2010. Annual ORLS incidence rates were also stable from 1979 to 1998. Proportions of new uveal malignancies in adults for 2006-10 were 88% (382 people/year) choroidal and 12% (52) ciliary body/iris. Incidence rates increased with increasing age and were higher in men than women. Geographical analysis showed variation across local authorities (LA) in incidence rates, from 0.1 to 1.9
Squamous-Cell Epithelioma of the Nail Bed | Springer for Research & DevelopmentSquamous-Cell Epithelioma of the Nail Bed | Springer for Research & Development
Squamous-cell epithelioma of the nail bed is a rare, locally malignant lesion mainly affecting the fingers, seldom the toes. It is by far the most common of the malignant tumours of the hand...
Mouse mAb anti- human transferrin Receptor (CD71), Clone CY-TFR | esiservizi.comMouse mAb anti- human transferrin Receptor (CD71), Clone CY-TFR | esiservizi.com
Product Name: Mouse mAb anti- human transferrin Receptor (CD71), Clone CY-TFRCollection: AntibodySub Category: Monoclonal AntibodyImmunogen: Purified human
Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized...Selumetinib in Combination With Dacarbazine in Patients With Metastatic Uveal Melanoma: A Phase III, Multicenter, Randomized...
PurposeUveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting. Selumetinib (AZD6244, ARRY-142886) is an oral, potent, and selective MEK1/2 inhibitor with a short half-life, which demonstrated single-agent activity in patients with metastatic uveal melanoma in a randomized phase II trial.Methods: The Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT) study was a phase III, double-blind trial (ClinicalTrial.gov identifier: NCT01974752) in which patients with metastatic uveal melanoma and no prior systemic therapy were randomly assigned (3:1) to selumetinib (75 mg twice daily) plus dacarbazine (1,000 mg/m(2) intravenously on day 1 of every 21-day cycle) or placebo plus dacarbazine. The primary end point was progression-free survival (PFS) by blinded independent central radiologic review. Secondary end points included overall survival and objective response rate.Results: A ...
IJMS | Free Full-Text | Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of...IJMS | Free Full-Text | Targeted Silencing of MART-1 Gene Expression by RNA Interference Enhances the Migration Ability of...
Uveal melanoma (UM) is the most common primary intraocular malignancy and the leading potentially fatal primary intraocular disease in adults. Melanoma antigen recognized by T-cells (MART-1) has been studied extensively as a clinically important diagnostic marker for melanoma, however, its biological function remains unclear. In the present study, the UM cell line SP6.5, which showed a high level of MART-1 expression, was subjected to small interfering RNA-mediated silencing of MART-1. Silencing of MART-1 expression increased the migration ability of SP6.5 cells and down-regulated the expression of the metastasis suppressor NM23. Our results suggest that MART-1 is a candidate target for the development of therapeutic strategies for UM and in particular for the suppression of metastasis associated with this malignancy.
Odontogenic epithelioma | Article about odontogenic epithelioma by The Free DictionaryOdontogenic epithelioma | Article about odontogenic epithelioma by The Free Dictionary
Looking for odontogenic epithelioma? Find out information about odontogenic epithelioma. An epithelial tumor associated with the enamel organ; cells of basal layers resemble the ameloblast. Also known as adamantinoma Explanation of odontogenic epithelioma
PHYSICAL CARCINOGENESISPHYSICAL CARCINOGENESIS
Radiation Carcinogenesis Perhaps the first documented example of the induction of neoplasia by ionizing radiation was that of atypical epithelial hyperplasias and malignant epitheliomas observed on the hands of ra- ...
New report: Basal cell carcinoma (basal cell epithelioma) pipeline review H2 2017 - WhaTechNew report: Basal cell carcinoma (basal cell epithelioma) pipeline review H2 2017 - WhaTech
Basal Cell Carcinoma (Basal Cell Epithelioma) Pipeline and Therapeutics Development H1 2017 provides a comprehensive information on the therapeutics under development for Basal Cell Carcinoma (Basal Cell Epithelioma), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Dermatologica SinicaDermatologica Sinica
Pilomatricoma, also known as calcifying epithelioma of Malherbe, is an unusual, but not particularly rare tumor. We excised 9 pilomatricomas from 8 patients in the past 11 months. The ages ranged from 6 months to 63 years, most patients were under 30 years old. The male to female ratio was 3:5. Their sizes were smaller than 2㎝, and the duration prior to excision varied from 2 months to 2years. They were more common on the head and upper extremities. Five tumors were normal skin-colored, and th ..................More ...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
CarcinomaAdipose Tissue, BrownCarcinoma, Squamous CellCarcinoma, HepatocellularAdipocytes, BrownCarcinoma in SituCarcinoma, PapillaryLiver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellImmunohistochemistryCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellPhaeophytaTumor Markers, BiologicalCarcinoma, MedullaryAdenocarcinomaCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessCell Line, TumorNasopharyngeal NeoplasmsPrognosisThyroid NeoplasmsBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsRats, Inbred BNCarcinoma, EmbryonalThermogenesisEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsColonic NeoplasmsAdrenocortical CarcinomaCarcinoma, VerrucousRNA, MessengerCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsSkin NeoplasmsNeoplasm ProteinsStomach NeoplasmsNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellDNA, NeoplasmAntineoplastic AgentsRetrospective StudiesImmunoenzyme TechniquesLaryngeal NeoplasmsUterine Cervical NeoplasmsReverse Transcriptase Polymerase Chain ReactionNeoplasm TransplantationNeoplasms, Multiple PrimarySurvival RateAdenocarcinoma, FollicularSurvival AnalysisTreatment OutcomeMitochondrial ProteinsAdenocarcinoma, MucinousAntigens, NeoplasmEmbryonal Carcinoma Stem CellsPrecancerous ConditionsCarcinoma, Papillary, FollicularGallbladder NeoplasmsTime FactorsCarcinoma, Non-Small-Cell LungTumor Suppressor Protein p53Cell ProliferationEndometrial NeoplasmsApoptosisAdenocarcinoma, Clear CellDisease ProgressionColorectal Neoplasmsalpha-FetoproteinsTongue NeoplasmsCold TemperatureBase SequenceCell DivisionPancreatic NeoplasmsCystadenocarcinoma, SerousCarcinoma, Lewis LungMolecular Sequence DataCombined Modality TherapyMutationBronchial NeoplasmsSalivary Gland NeoplasmsTissue Array AnalysisBlotting, WesternDisease-Free SurvivalKeratinsCisplatinFollow-Up StudiesTomography, X-Ray ComputedRNA, NeoplasmCell Transformation, NeoplasticBrown Recluse SpiderFatal OutcomeBiopsyAntibodies, MonoclonalTransplantation, HeterologousKi-67 AntigenGenes, p53TroutAdenocarcinoma, PapillaryGene ExpressionAdipose Tissue, WhiteGene Expression ProfilingBody Temperature RegulationChemoembolization, TherapeuticIon ChannelsLoss of HeterozygosityMammary Neoplasms, ExperimentalKaplan-Meier EstimateCarrier ProteinsSignal TransductionMembrane ProteinsAdipocytes, WhiteCell DifferentiationNeovascularization, PathologicCarcinoma, BasosquamousTranscription FactorsReceptor, erbB-2Sensitivity and SpecificityThyroidectomyCarcinoembryonic AntigenAntineoplastic Combined Chemotherapy ProtocolsGenes, Tumor SuppressorNeoplasms, ExperimentalTransfectionBreastCell LineDown-RegulationCadherinsPapillomaviridaeRectal NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarSargassumHyperplasiaTumor Suppressor ProteinsUp-RegulationLiver Neoplasms, ExperimentalCarcinoma, Pancreatic DuctalLiver CirrhosisPhenotypeAdrenal Cortex NeoplasmsUrotheliumVulvar NeoplasmsSeaweedCase-Control StudiesFucusHaresOropharyngeal NeoplasmsReceptor, Epidermal Growth FactorReceptors, EstrogenPapillomaRisk FactorsTumor BurdenFluorouracilMicrosatellite RepeatsPromoter Regions, GeneticDNA-Binding ProteinsLymph NodesCell SurvivalPhenylurea CompoundsLiverXenograft Model Antitumor AssaysIn Situ Hybridization, FluorescenceNeoplasm GradingMice, Inbred BALB CBile Duct NeoplasmsCarcinoma, Giant CellUrologic NeoplasmsDose-Response Relationship, DrugNiacinamideProto-Oncogene ProteinsGene AmplificationDNA Mutational AnalysisOligonucleotide Array Sequence AnalysisKeratin-7DNA PrimersBenzenesulfonatesUreteral NeoplasmsIn Situ HybridizationHepatectomyNeoplasmsCarcinoma, Ehrlich TumorNuclear Proteins
Calcium-sensing receptorCalcium-sensing receptor
Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM (Aug 1996). "Expression and ... "Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin ... Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, Seidman JG (Dec 1993). "Mutations in the ... Pearce SH, Trump D, Wooding C, Besser GM, Chew SL, Grant DB, Heath DA, Hughes IA, Paterson CR, Whyte MP (Dec 1995). "Calcium- ...
AMG319AMG319
Brown, M; Cardozo, M; Chen, Y; Duquette, J; Fisher, B; Gonzalez-Lopez de Turiso, F; He, X; Henne, KR; Hu, YL; Hungate, R; ... Pearce, Wayne; Lim, Ee Lyn; Bouabe, Hicham; Scudamore, Cheryl L.; Hancox, Timothy (2014). "Inactivation of PI(3)K p110δ breaks ... negative head and neck squamous-cell carcinoma (HNSCC) (prior to resection surgery). Duvelisib Idelalisib Cushing, TD; Hao, X; ...
SerpinSerpin
Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike ... Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA (November ... Examples of cross-class inhibitory serpins include serpin B4 a squamous cell carcinoma antigen 1 (SCCA-1) and the avian serpin ... Zhang Q, Buckle AM, Law RH, Pearce MC, Cabrita LD, Lloyd GJ, Irving JA, Smith AI, Ruzyla K, Rossjohn J, Bottomley SP, Whisstock ...
Bradshaw LectureBradshaw Lecture
Missing or empty ,title= (help) Handley, R. S. (August 1975). "Carcinoma of the breast". Annals of the Royal College of ... Bedford, D. E.; Muir, D. C. (1959). "James William Brown". Heart. 21: 284-8. doi:10.1136/hrt.21.2.284. "Obituary". BMJ. 1 (4874 ... Some Points in Heredity 1910 Alfred Pearce Gould, Cancer 1909 Francis Richardson Cross, The Brain Structures concerned in ... Morgan, C. Naunton (February 1965). "Carcinoma of the Rectum: Bradshaw Lecture delivered at the Royal College of Surgeons of ...
Cystatin CCystatin C
Strojan P, Oblak I, Svetic B, Smid L, Kos J (May 2004). "Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of ... Eriksson P, Jones KG, Brown LC, Greenhalgh RM, Hamsten A, Powell JT (January 2004). "Genetic approach to the role of cysteine ... "Entrez Gene: CST3 cystatin C (amyloid angiopathy and cerebral hemorrhage)". Hwang SJ, Yang Q, Meigs JB, Pearce EN, Fox CS (2007 ...
ThyroidThyroid
Malignant thyroid cancers are most often carcinomas, although cancer can occur in any tissue that the thyroid consists of, ... ISBN 978-1-284-03445-5. Leung, Angela; Braverman, Lewis; Pearce, Elizabeth (13 November 2012). "History of U.S. Iodine ... Pediatrics, American Academy of; Rose, Susan R.; Association, American Thyroid; Brown, Rosalind S.; Society, Lawson Wilkins ... Malignant nodules, which only occur in about 5% of nodules, include follicular, papillary, medullary carcinomas and metastases ...
Mechanistic target of rapamycinMechanistic target of rapamycin
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM (December 2006). " ... Constitutively activated mTOR functions in supplying carcinoma cells with oxygen and nutrients by increasing the translation of ... Pearce et al., 2007; Sarbassov et al., 2004)(Figure 1B). Rictor and mSIN1 are both critical to mTORC2 function. Figure 1: ... Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL (June 1994). "A mammalian protein targeted by G1- ...
Chromosome 6 (human)Chromosome 6 (human)
Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, ... Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, ... linked to Hepatocellular carcinoma and Chordoma (6q27) TAAR1: trace amine associated receptor 1 (6q23.1) TAAR2: trace amine ... DQB1 X-linked sideroblastic anemia Epilepsy Guillain Barre Syndrome Chordoma Hepatocellular carcinoma G-banding ideograms of ...
Ulysses S. GrantUlysses S. Grant
Gratz Brown, for vice-president. The Democrats adopted the Greeley-Brown ticket and the Liberals party platform. The opposition ... Today, medical historians believed he suffered from a T1N1 carcinoma of the tonsillar fossa. White said Grant, "demonstrated a ... Created by sculptor Henry Merwin Shrady and architect Edward Pearce Casey, and dedicated in 1922, it overlooks the Capitol ... Union forces captured Brown's Ferry and opened a supply line to Bridgeport. On November 23, Grant organized three armies to ...
Repetitive strain injuryRepetitive strain injury
Byssinosis ("brown lung"). *Chalicosis. *Chimney sweeps' carcinoma. *Chronic solvent-induced encephalopathy (CSE) ... Pearce, J. M. (April 2009). "James Paget's median nerve compression (Putnam's acroparaesthesia)". Pract Neurol. 9 (2): 96-9. ...
Adrenal glandAdrenal gland
Adrenal carcinomas are very rare, with an incidence of 1 case per million per year. Pheochromocytomas are tumors of the adrenal ... Pearce, JM (2004). "Thomas Addison (1793-1860)". Journal of the Royal Society of Medicine. 97 (6): 297-300. doi:10.1258/jrsm. ... The cells contain relatively small quantities of cytoplasm and lipid droplets, and sometimes display brown lipofuscin pigment. ...
CoffeeCoffee
Brown, OI; Allgar, V; Wong, K-Y K (2016). "Coffee reduces death after myocardial infarction: a meta-analysis". Coronary Artery ... Pearce, Fred (February 25, 2006). "Earth: The parched planet". New Scientist. Retrieved January 5, 2010. Martin, Deborah L.; ... Bravi, F.; Tavani, A.; Bosetti, C.; Boffetta, P.; La Vecchia, C. (2016). "Coffee and the risk of hepatocellular carcinoma and ... Brown, Alton. "True Brew". Food Network. Archived from the original on April 16, 2003. Retrieved January 11, 2010. New Process ...
Hematopoietic stem cell transplantationHematopoietic stem cell transplantation
Oral carcinoma[edit]. Patients after HSCT are at a higher risk for oral carcinoma. Post-HSCT oral cancer may have more ... Burt RK, Loh Y, Pearce W, et al. (2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant ... performed a stem cell transplant for leukemia patient Timothy Ray Brown, who was also HIV-positive.[57] From 60 matching donors ...
Ulcerative colitisUlcerative colitis
Strøbæk D.; Brown D. T.; Jenkins D. P.; Chen Y. J.; Coleman N.; Ando Y.; Christophersen P. (2013). "NS6180, a new KCa3. 1 ... Jowett SL, Seal CJ, Pearce MS, Phillips E, Gregory W, Barton JR, Welfare MR (October 2004). "Influence of dietary factors on ... or documented or strongly suspected carcinoma. Surgery is also indicated for patients with severe colitis or toxic megacolon. ...
Chromosome 10 (human)Chromosome 10 (human)
Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, ... Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD ... multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) RPP30: ribonuclease P protein subunit p30 ...
John Frank (epidemiologist)John Frank (epidemiologist)
Brown J, Mackay D, Demou E, Craig J, Frank J, Macdonald EB. The EASY Sickness Absence Service: a four year evaluation of the ... Van der Sluijs W, Haseen F, Miller M, MacGregor A, Sharp C, AmosA, Best C, Stead M, Eadie D, Pearce J, Frank J, Haw S. 'It ... Occult blood screening for colorectal carcinoma: 3. Yield and costs. American Journal of Preventive Medicine 1985; 1(5):18-24. ... Brown J, Neary J, Kattikireddi SV, Thomson H, McQuaid R, Leyland AH, Frank J, Jeavons L, de Pellette P, Kiran S., Macdonald EB ...
Adrenal glandAdrenal gland
Pearce, JM (2004). "Thomas Addison (1793-1860)". Journal of the Royal Society of Medicine. 97 (6): 297-300. doi:10.1258/jrsm. ... They are seen in around 3.4% of CT scans,[7] and in most cases they are benign adenomas.[47] Adrenal carcinomas are very rare, ... The cells contain relatively small quantities of cytoplasm and lipid droplets, and sometimes display brown lipofuscin pigment.[ ...
ThyroidThyroid
Malignant nodules, which only occur in about 5% of nodules, include follicular, papillary, medullary carcinomas and metastases ... Pediatrics, American Academy of; Rose, Susan R.; Association, American Thyroid; Brown, Rosalind S.; Society, Lawson Wilkins ... Leung, Angela; Braverman, Lewis; Pearce, Elizabeth (13 November 2012). "History of U.S. Iodine Fortification and ... Malignant thyroid cancers are most often carcinomas, although cancer can occur in any tissue that the thyroid consists of, ...
Calcium-sensing receptorCalcium-sensing receptor
Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM (Aug 1996). "Expression and ... "Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin ... Pearce SH, Trump D, Wooding C, Besser GM, Chew SL, Grant DB, Heath DA, Hughes IA, Paterson CR, Whyte MP (Dec 1995). "Calcium- ... Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, Seidman JG (Dec 1993). "Mutations in the ...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
CarcinomaAdipose Tissue, BrownCarcinoma, Squamous CellCarcinoma, HepatocellularAdipocytes, BrownCarcinoma in SituCarcinoma, PapillaryLiver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellImmunohistochemistryCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellPhaeophytaTumor Markers, BiologicalCarcinoma, MedullaryAdenocarcinomaCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessCell Line, TumorNasopharyngeal NeoplasmsPrognosisThyroid NeoplasmsBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsRats, Inbred BNCarcinoma, EmbryonalThermogenesisEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsColonic NeoplasmsAdrenocortical CarcinomaCarcinoma, VerrucousRNA, MessengerCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsSkin NeoplasmsNeoplasm ProteinsStomach NeoplasmsNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellDNA, NeoplasmAntineoplastic AgentsRetrospective StudiesImmunoenzyme TechniquesLaryngeal NeoplasmsUterine Cervical NeoplasmsReverse Transcriptase Polymerase Chain ReactionNeoplasm TransplantationNeoplasms, Multiple PrimarySurvival RateAdenocarcinoma, FollicularSurvival AnalysisTreatment OutcomeMitochondrial ProteinsAdenocarcinoma, MucinousAntigens, NeoplasmEmbryonal Carcinoma Stem CellsPrecancerous ConditionsCarcinoma, Papillary, FollicularGallbladder NeoplasmsTime FactorsCarcinoma, Non-Small-Cell LungTumor Suppressor Protein p53Cell ProliferationEndometrial NeoplasmsApoptosisAdenocarcinoma, Clear CellDisease ProgressionColorectal Neoplasmsalpha-FetoproteinsTongue NeoplasmsCold TemperatureBase SequenceCell DivisionPancreatic NeoplasmsCystadenocarcinoma, SerousCarcinoma, Lewis LungMolecular Sequence DataCombined Modality TherapyMutationBronchial NeoplasmsSalivary Gland NeoplasmsTissue Array AnalysisBlotting, WesternDisease-Free SurvivalKeratinsCisplatinFollow-Up StudiesTomography, X-Ray ComputedRNA, NeoplasmCell Transformation, NeoplasticBrown Recluse SpiderFatal OutcomeBiopsyAntibodies, MonoclonalTransplantation, HeterologousKi-67 AntigenGenes, p53TroutAdenocarcinoma, PapillaryGene ExpressionAdipose Tissue, WhiteGene Expression ProfilingBody Temperature RegulationChemoembolization, TherapeuticIon ChannelsLoss of HeterozygosityMammary Neoplasms, ExperimentalKaplan-Meier EstimateCarrier ProteinsSignal TransductionMembrane ProteinsAdipocytes, WhiteCell DifferentiationNeovascularization, PathologicCarcinoma, BasosquamousTranscription FactorsReceptor, erbB-2Sensitivity and SpecificityThyroidectomyCarcinoembryonic AntigenAntineoplastic Combined Chemotherapy ProtocolsGenes, Tumor SuppressorNeoplasms, ExperimentalTransfectionBreastCell LineDown-RegulationCadherinsPapillomaviridaeRectal NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarSargassumHyperplasiaTumor Suppressor ProteinsUp-RegulationLiver Neoplasms, ExperimentalCarcinoma, Pancreatic DuctalLiver CirrhosisPhenotypeAdrenal Cortex NeoplasmsUrotheliumVulvar NeoplasmsSeaweedCase-Control StudiesFucusHaresOropharyngeal NeoplasmsReceptor, Epidermal Growth FactorReceptors, EstrogenPapillomaRisk FactorsTumor BurdenFluorouracilMicrosatellite RepeatsPromoter Regions, GeneticDNA-Binding ProteinsLymph NodesCell SurvivalPhenylurea CompoundsLiverXenograft Model Antitumor AssaysIn Situ Hybridization, FluorescenceNeoplasm GradingMice, Inbred BALB CBile Duct NeoplasmsCarcinoma, Giant CellUrologic NeoplasmsDose-Response Relationship, DrugNiacinamideProto-Oncogene ProteinsGene AmplificationDNA Mutational AnalysisOligonucleotide Array Sequence AnalysisKeratin-7DNA PrimersBenzenesulfonatesUreteral NeoplasmsIn Situ HybridizationHepatectomyNeoplasmsCarcinoma, Ehrlich TumorNuclear Proteins
BB LRGPHOR Ch17 - Mycoses & Noninfectious Diseases Flashcards by Ky Dehlinger | BrainscapeBB LRGPHOR Ch17 - Mycoses & Noninfectious Diseases Flashcards by Ky Dehlinger | Brainscape
Brown Pearce carcinoma. 62 Discoloration is due to deposition of what substance? ...
brainscape.com
Plus itPlus it
With the exception of the Brown-Pearce carcinoma, no morphological changes in the tumors of treated animals could be detected. ... anterior chamber transplants of an undifferentiated squamous-cell carcinoma (Brown-Pearce) in rabbits eyes were similarly ... hand suggests that the triazolopyrimidine distinguishes a biochemical difference between normal tissues and certain carcinomas. ...
cancerres.aacrjournals.org
Occupational cancer in developed countries | Environmental Health | Full TextOccupational cancer in developed countries | Environmental Health | Full Text
Checkoway H, Pearce NE, Crawford-Brown DJ: Research methods in occupational epidemiology. 1989, Oxford University Press, New ... Doll R, Peto R: Cigarette smoking and bronchial carcinoma: dose and time relationship among regular smokers and life long non- ...
ehjournal.biomedcentral.com
Extravasation and Interstitial Transport in Tumors | SpringerLinkExtravasation and Interstitial Transport in Tumors | SpringerLink
Brown-Pearce carcinoma) tissue in the rabbit, J. Pathol. Bacteriol. 62:313-333.PubMedCrossRefGoogle Scholar ... Effect of osmotic pressure on uptake of chemotherapeutic agents by carcinoma cells, Cancer Res. 50:4704-4708.PubMedGoogle ... ZCE/CHA-indium-111-BLEDTA-IV clinical imaging in colorectal carcinoma, Antibody Immunoconjugates Radiopharm. 2:1-13.Google ... Interstitial hypertension in cervical carcinomas in humans: Possible correlation with tumor oxygenation and radiation response ...
link.springer.com
Patent US6506559 - Genetic inhibition by double-stranded RNA - Google PatentsPatent US6506559 - Genetic inhibition by double-stranded RNA - Google Patents
... carcinoma (e.g., Walker, basal cell, basosquamous, Brown-Pearce, ductal, Ehrlich tumor, in situ, Krebs 2, Merkel cell, mucinous ... ovarian carcinoma, rhabdomyosarcoma, sarcoma (e.g., Ewing, experimental, Kaposi, and mast cell), neoplasms (e.g., bone, breast ...
google.com
INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR | JEMINCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR | JEM
... study has been made of an antibody which appears in the blood of certain rabbits implanted with the Brown-Pearce carcinoma or ... INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR. Ian MacKenzie, John G. Kidd ... The observations as a whole seem to indicate that this constituent of the Brown-Pearce tumor differs notably from certain other ... INCIDENCE AND SPECIFICITY OF THE ANTIBODY FOR A DISTINCTIVE CONSTITUENT OF THE BROWN-PEARCE TUMOR ...
jem.rupress.org
Therapy and diagnosis of conditions related to telomere length and/or telomerase activity - Board of Regents, The University of...Therapy and diagnosis of conditions related to telomere length and/or telomerase activity - Board of Regents, The University of...
... carcinoma (e.g., Walker, basal cell, basosquamous, Brown-Pearce, ductal, Ehrlich tumor, in situ, Krebs 2, merkel cell, mucinous ... 10 is a copy of an autoradiogram showing TRF lengths of ovarian carcinoma and control normal cells. DNA from cells in ascitic ... Characteristics of Ovarian Carcinoma Tumor Cells from Ascitic Fluid Mean TRF Telomerase Patient Description Length (kbp) ... Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. USA 91:2900-2904 (1994). Strahl and ...
freepatentsonline.com
Prognostic biomarkers in endometrial and ovarian carcinoma | SpringerLinkPrognostic biomarkers in endometrial and ovarian carcinoma | SpringerLink
... and ovarian carcinoma (OC). In EC, prognosis still relies on conventional pathological features such as... ... Brown LA, Kalloger SE, Miller MA, IeM S, McKinney SE, Santos JL, Swenerton K, Spellman PT, Gray J, Gilks CB, Huntsman DG (2008 ... Pearce CL, Schildkraut JM, Menon U, Kjaer SK, Levine DA, Gronwald J, Culver HA, Whittemore AS, Karlan BY, Lambrechts D, ... Endometrial carcinoma Ovarian carcinoma Biomarkers Prognosis This is a preview of subscription content, log in to check access ...
link.springer.com
Prevention and Treatment of Peritoneal Metastases: a Comprehensive Review | Springer for Research & DevelopmentPrevention and Treatment of Peritoneal Metastases: a Comprehensive Review | Springer for Research & Development
Brown-Pearce carcinoma) tissue in the rabbit. J Pathol Bacteriol 62:313-333PubMedCrossRefGoogle Scholar ... Karnofsky DA, Abelmann WH, Craver LF et al (1948) The use of the nitrogen mustards in the palliative treatment of carcinoma. ... Sugarbaker PH, Sardi A, Brown G, Dromain C, Rousset P, Jelinek JS (2017) Concerning CT features used to select patients for ... for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. Eur J Surg Oncol 22:1570-1575 ...
rd.springer.com
US4321919A - Method and system for externally treating human blood - Google PatentsUS4321919A - Method and system for externally treating human blood - Google Patents
Effect of human plasmin on the toxic effects and growth of blood‐borne metastasis of the brown‐pearce carcinoma and the V2 ... Brown 1979. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. ... carcinoma of rabbit. US5290221A (en) 1994-03-01. Systems for eradicating contaminants using photoactive materials in fluids ...
patents.google.com
Význam urokinázy a jejích inhibitorů pro invazi a metastazování zhoubných nádorů | proLékaře.czVýznam urokinázy a jejích inhibitorů pro invazi a metastazování zhoubných nádorů | proLékaře.cz
Effect of human plasmin on the toxic effects and growth of blood borne metastasis of the Brown-Pearce carcinoma and the V2 ... Endogenous receptor-bound urokinase mediates tissue invasion of the human lung carcinoma cell lines A549 and Calu-1. Cancer Res ... Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its ... Interactions between human colon carcinoma cells, fibroblasts and monocytic cells in coculture-regulation of cathepsin B ...
prolekare.cz
Staff Profile - Northern Institute for Cancer Research - Newcastle UniversityStaff Profile - Northern Institute for Cancer Research - Newcastle University
Brown M, Pearce M, Salotti J, Craft A, Hale J. European Bone Tumour Outcome Study (EBTOS): Overview of health related quality ... Seasonality in the incidence of cervical carcinoma in teenagers and young adults in northern England, 1968-2005. Chronobiology ... Pearce MS, Salotti JA, Howe NL, McHugh K, Kim KP, Lee C, Craft AW, de Gonzalez AB, Parker L. CT Scans in Young People in Great ... Pearce M, Salotti J, McHugh K, Kim KP, Craft A, Lubin J, Ron E, Parker L. Socio-economic variation in the use of CT scans in ...
ncl.ac.uk
Alternative Medizin: Krebs 12 - LiteraturAlternative Medizin: Krebs 12 - Literatur
... and growth of blood borne metastases of the Brown-Pearce carcinoma and the V2 carcinoma of the rabbit Cancer 9,6 1147-1152 ... I. Growth of Brown-Pearce carcinomas in rabbits treated with living or killed haemolytic streptococci Acta Pathol Microbiol ... Ellen Hodgson Brown: Forbidden Medicine... Lee: The war between health foods and death foods National Health Federation ... Brown, Wood, Smith: Sodium cyanide as a cancer chemotherapeutic agent Am J Obstet Gynecol 80,5 907-918 11.1960 Na-Cyanid als ...
mweisser.50g.com
Carcinoma, Lewis Lung | Harvard Catalyst Profiles | Harvard CatalystCarcinoma, Lewis Lung | Harvard Catalyst Profiles | Harvard Catalyst
Carcinoma, Transitional Cell. *Carcinoma, Verrucous. *Neoplasms, Experimental. *Carcinoma 256, Walker. *Carcinoma, Brown-Pearce ... A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a ... "Carcinoma, Lewis Lung" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Carcinoma, Lewis Lung" by people in Harvard Catalyst Profiles ...
connects.catalyst.harvard.edu
Mammary Neoplasms, Experimental | Harvard Catalyst Profiles | Harvard CatalystMammary Neoplasms, Experimental | Harvard Catalyst Profiles | Harvard Catalyst
Carcinoma, Brown-Pearce. *Carcinoma, Ehrlich Tumor. *Carcinoma, Krebs 2. *Carcinoma, Lewis Lung ...
connects.catalyst.harvard.edu
Docphin | Medical Research Articles Published in February 1940 | Page 1 of 1Docphin | Medical Research Articles Published in February 1940 | Page 1 of 1
A DISTINCTIVE SUBSTANCE ASSOCIATED WITH THE BROWN-PEARCE RABBIT CARCINOMA : I. PRESENCE AND SPECIFICITY OF THE SUBSTANCE AS ...
docphin.com
NeoplasmaNeoplasma
The time sequence of changes in the level of properdin in rabbits with Brown-Pearce carcinoma.. ... The time sequence of changes in the level of properdin in rabbits with Brown-Pearce carcinoma.. ...
neoplasma.sk
Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and...Deduction of Novel Genes Potentially Involved in Upper Tract Urothelial Carcinoma Using Next-Generation Sequencing and...
Kastl L, Brown I, Schofield AC. miRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer ... Naba A, Pearce OMT, Del Rosario A. et al. Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using ... Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res. 2005;11: ... Increased upper and lower tract urothelial carcinoma in patients with end-stage renal disease: a nationwide cohort study in ...
medsci.org
Erik Alexander | Harvard Catalyst Profiles | Harvard CatalystErik Alexander | Harvard Catalyst Profiles | Harvard Catalyst
Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, ... A 35-year-old woman with recurrent goiter and ductal carcinoma of the breast. N Engl J Med. 2013 Jun 20; 368(25):2416-24. PMID ... Alexander E, Rossitch E, Small K, Rosenwasser GO, Abson P. Merkel cell carcinoma. Long term survival in a patient with proven ... The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration ...
connects.catalyst.harvard.edu
NAVER Academic > Search...NAVER Academic > Search...
Animals, Carcinoma, Brown-Pearce, Cricetinae, Guinea Pigs, Lymphoma, etiology, pathology, Melanoma, Mice, Neoplasm ...
academic.naver.com
A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical...A critical analysis of the cytoreductive surgery with hyperthermic intraperitoneal chemotherapy combo in the clinical...
The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J ... for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. Eur J Surg Oncol 2013;39:1435- ... peritoneal lavage as a standard prophylactic strategy for peritoneal recurrence in patients with gastric carcinoma. Ann Surg ...
tgh.amegroups.com
Buy Metazole (Metronidazole) OnlineBuy Metazole (Metronidazole) Online
The sera of rabbits carrying tar papillomas or the Brown-Pearce carcinoma proved wholly devoid of effect on the virus. ... Four cases of juvenile-onset recurrent respiratory papillomatosis progressing to carcinoma (no history of smoking or ... Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma. Arsenic for ...
saladgaffe.tk
Ahrens, T., Sleeman, J.P., Schempp, ... Herrlich, P., and Simon, J.C. ...Ahrens, T., Sleeman, J.P., Schempp, ... Herrlich, P., and Simon, J.C. ...
Ide, A. G., Baker, N. H. & Warren, S. L. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the ... Zhang,Y.L., Pang,L.Q., Wu,Y., Wang,X.Y., Wang,C.Q., Fan,Y. Significance of BclxL in human colon carcinoma. World J ... 2 new bladder carcinoma markers. Urologe A. 40: 121-126, 2001. Heng,H.H.Q., Spyropoulos,B., Moens ,P. FISH technology in ... Chaly, N., Bladon ,T., Setterfield ,G., Little, J .E., Kaplan ,J .G., and Brown, D. L. Changes in distribution of nuclear ...
spotidoc.com
Calcium-sensing receptor - WikipediaCalcium-sensing receptor - Wikipedia
Bai M, Quinn S, Trivedi S, Kifor O, Pearce SH, Pollak MR, Krapcho K, Hebert SC, Brown EM (Aug 1996). "Expression and ... "Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin ... Pearce SH, Trump D, Wooding C, Besser GM, Chew SL, Grant DB, Heath DA, Hughes IA, Paterson CR, Whyte MP (Dec 1995). "Calcium- ... Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, Seidman JG (Dec 1993). "Mutations in the ...
en.m.wikipedia.org
NANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF - Patent applicationNANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF - Patent application
... carcinoma (e.g., Walker, basal cell, basosquamous, Brown-Pearce, ductal, Ehrlich tumor, non-small cell lung, oat cell, ... ovarian carcinoma, rhabdomyosarcoma, sarcoma (e.g., Ewing, experimental, Kaposi, and mast cell), neurofibromatosis, and ... adeno-carcinoma, adenoma, cholangioma, cholesteatoma, cylindroma, cystadenocarcinoma, cystadenoma, granulosa cell tumor, ...
patentsencyclopedia.com
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
CarcinomaAdipose Tissue, BrownCarcinoma, Squamous CellCarcinoma, HepatocellularAdipocytes, BrownCarcinoma in SituCarcinoma, PapillaryLiver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellImmunohistochemistryCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellPhaeophytaTumor Markers, BiologicalCarcinoma, MedullaryAdenocarcinomaCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessCell Line, TumorNasopharyngeal NeoplasmsPrognosisThyroid NeoplasmsBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsRats, Inbred BNCarcinoma, EmbryonalThermogenesisEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsColonic NeoplasmsAdrenocortical CarcinomaCarcinoma, VerrucousRNA, MessengerCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsSkin NeoplasmsNeoplasm ProteinsStomach NeoplasmsNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellDNA, NeoplasmAntineoplastic AgentsRetrospective StudiesImmunoenzyme TechniquesLaryngeal NeoplasmsUterine Cervical NeoplasmsReverse Transcriptase Polymerase Chain ReactionNeoplasm TransplantationNeoplasms, Multiple PrimarySurvival RateAdenocarcinoma, FollicularSurvival AnalysisTreatment OutcomeMitochondrial ProteinsAdenocarcinoma, MucinousAntigens, NeoplasmEmbryonal Carcinoma Stem CellsPrecancerous ConditionsCarcinoma, Papillary, FollicularGallbladder NeoplasmsTime FactorsCarcinoma, Non-Small-Cell LungTumor Suppressor Protein p53Cell ProliferationEndometrial NeoplasmsApoptosisAdenocarcinoma, Clear CellDisease ProgressionColorectal Neoplasmsalpha-FetoproteinsTongue NeoplasmsCold TemperatureBase SequenceCell DivisionPancreatic NeoplasmsCystadenocarcinoma, SerousCarcinoma, Lewis LungMolecular Sequence DataCombined Modality TherapyMutationBronchial NeoplasmsSalivary Gland NeoplasmsTissue Array AnalysisBlotting, WesternDisease-Free SurvivalKeratinsCisplatinFollow-Up StudiesTomography, X-Ray ComputedRNA, NeoplasmCell Transformation, NeoplasticBrown Recluse SpiderFatal OutcomeBiopsyAntibodies, MonoclonalTransplantation, HeterologousKi-67 AntigenGenes, p53TroutAdenocarcinoma, PapillaryGene ExpressionAdipose Tissue, WhiteGene Expression ProfilingBody Temperature RegulationChemoembolization, TherapeuticIon ChannelsLoss of HeterozygosityMammary Neoplasms, ExperimentalKaplan-Meier EstimateCarrier ProteinsSignal TransductionMembrane ProteinsAdipocytes, WhiteCell DifferentiationNeovascularization, PathologicCarcinoma, BasosquamousTranscription FactorsReceptor, erbB-2Sensitivity and SpecificityThyroidectomyCarcinoembryonic AntigenAntineoplastic Combined Chemotherapy ProtocolsGenes, Tumor SuppressorNeoplasms, ExperimentalTransfectionBreastCell LineDown-RegulationCadherinsPapillomaviridaeRectal NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarSargassumHyperplasiaTumor Suppressor ProteinsUp-RegulationLiver Neoplasms, ExperimentalCarcinoma, Pancreatic DuctalLiver CirrhosisPhenotypeAdrenal Cortex NeoplasmsUrotheliumVulvar NeoplasmsSeaweedCase-Control StudiesFucusHaresOropharyngeal NeoplasmsReceptor, Epidermal Growth FactorReceptors, EstrogenPapillomaRisk FactorsTumor BurdenFluorouracilMicrosatellite RepeatsPromoter Regions, GeneticDNA-Binding ProteinsLymph NodesCell SurvivalPhenylurea CompoundsLiverXenograft Model Antitumor AssaysIn Situ Hybridization, FluorescenceNeoplasm GradingMice, Inbred BALB CBile Duct NeoplasmsCarcinoma, Giant CellUrologic NeoplasmsDose-Response Relationship, DrugNiacinamideProto-Oncogene ProteinsGene AmplificationDNA Mutational AnalysisOligonucleotide Array Sequence AnalysisKeratin-7DNA PrimersBenzenesulfonatesUreteral NeoplasmsIn Situ HybridizationHepatectomyNeoplasmsCarcinoma, Ehrlich TumorNuclear Proteins
Ovarian carcinomaHead and Neck Squamous Cell CarcSquamousHepatocellular carcinoma cellsEndometrial carcinomasRenal cell carcPapillaryRabbitsMammaryIncidenceCellsProgression2017LungPathologyBreastOutcomesClassificationPrimaryLiverKinaseTreatmentAnimalsCellGlobalStudy
Ovarian carcinoma4
Head and Neck Squamous Cell Carc1
  • In 2015/16 it started a phase II clinical trial as a neoadjuvant therapy for human papillomavirus (HPV) negative head and neck squamous-cell carcinoma (HNSCC) (prior to resection surgery). (wikipedia.org)
Squamous5
Hepatocellular carcinoma cells1
  • We show that the ATP-competitive inhibitor PP242, but not rapamycin, significantly down-regulates cholesterol biosynthesis genes in a 4E-BP1-dependent manner in NIH 3T3 cells, whereas S6 kinase 1 is the dominant regulator in hepatocellular carcinoma cells. (pnas.org)
Endometrial carcinomas1
Renal cell carc2
Papillary3
Rabbits1
Mammary1
  • Budhu AS, Noy N: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. (hmdb.ca)
Incidence1
Cells2
  • PTH-like protein from human renal carcinoma cells: structural and functional homology with PTH. (springer.com)
  • The cells contain relatively small quantities of cytoplasm and lipid droplets, and sometimes display brown lipofuscin pigment. (wikipedia.org)
Progression1
20171
  • Editors: Anne Blanchard & Roger Strand (Megaloceros Press, 2017) Det er ellers i prosjektet avsluttet to PhD-prosjekt i 2017 (Aziz og Krüger) og ytterligere en PhD avsluttes februar 2018 (Klingen). (ihelse.net)
Lung5
  • Carcinoma, Lewis Lung" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Carcinoma, Lewis Lung" by people in Harvard Catalyst Profiles by year, and whether "Carcinoma, Lewis Lung" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Carcinoma, Lewis Lung" by people in Profiles. (harvard.edu)
  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. (harvard.edu)
  • Lung carcinoma in African Americans and whites. (cdc.gov)
Pathology2
  • Llobet D, Pallares J, Yeramian A, Santacana M, Eritja N, Velasco A, Dolcet X, Matias-Guiu X (2009) Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints. (springer.com)
  • Excluding a diagnosis of Hepato cellular carcinoma (HCC) has proven difficult despite different suggested radiological investigation methods [ 5 , 6 ], particularly in patients with chronic liver disease [ 7 - 11 ], when HCC is an expected development and a more likely underlying pathology than is intrahepatic splenosis. (biomedcentral.com)
Breast1
  • Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC: Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (drugbank.ca)
Outcomes1
  • To improve outcomes of primary vaginal carcinoma, select referral oncology centers should see additional cases per month in order to plan appropriate randomized, prospective studies. (medscape.com)
Classification1
Primary3
Liver1
  • Diagnostic laparoscopy demonstrated a 3 cm exofitic dark brown splenunculus attached to the diaphragm and indenting the surface of segment 7 of the liver. (biomedcentral.com)
Kinase1
  • J:47692 Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR, Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin. (jax.org)
Treatment1
Animals1
Cell2
  • Clarke BA, Gilks CB (2010) Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type. (springer.com)
  • In general, fucoidans are a family of high molecular weight sulfated polysaccharides, widely dispersed in the cell walls of brown seaweed. (dadamo.com)
Global1
Study1
  • A recent study by Nellie Brown, director of the Chemical Hazards Information Program at Cornell University, found that 20% of US hair stylists leave their jobs because of work-related illness ( New York Times Magazine , 7 March 1993). (iloencyclopaedia.org)