Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Cysts of one of the parts of the mediastinum: the superior part, containing the trachea, esophagus, thoracic duct and thymus organs; the inferior middle part, containing the pericardium; the inferior anterior part containing some lymph nodes; and the inferior posterior part, containing the thoracic duct and esophagus.
Tumors or cancer of the LUNG.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Any fluid-filled closed cavity or sac (CYSTS) that is lined by an EPITHELIUM and found in the ESOPHAGUS region.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Tumors or cancer of the BRONCHI.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
A developmental anomaly in which a mass of nonfunctioning lung tissue lacks normal connection with the tracheobroncheal tree and receives an anomalous blood supply originating from the descending thoracic or abdominal aorta. The mass may be extralobar, i.e., completely separated from normally connected lung, or intralobar, i.e., partly surrounded by normal lung.
The excision of lung tissue including partial or total lung lobectomy.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Endoscopic examination, therapy or surgery of the bronchi.
Saccular protrusion beyond the wall of the ESOPHAGUS.
Hormones released from neoplasms or from other cells that are not the usual sources of hormones.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant epithelial tumor with a glandular organization.
Endoscopic examination, therapy or surgery of the pleural cavity.
Surgical incision into the chest wall.
Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.
Symmetrical osteitis of the four limbs, chiefly localized to the phalanges and the terminal epiphyses of the long bones of the forearm and leg, sometimes extending to the proximal ends of the limbs and the flat bones, and accompanied by dorsal kyphosis and joint involvement. It is often secondary to chronic conditions of the lungs and heart. (Dorland, 27th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Surgery performed on the lung.
The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart.
Presence of pus in a hollow organ or body cavity.
A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.
Tumors or cancer of the LIVER.
Methods and procedures for the diagnosis of disease or dysfunction by examination of the pathological site or operative field during surgical intervention.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Pathological processes involving any part of the LUNG.
An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.
Form of radioimmunoassay in which excess specific labeled antibody is added directly to the test antigen being measured.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
A usually spherical cyst, arising as an embryonic out-pouching of the foregut or trachea. It is generally found in the mediastinum or lung and is usually asymptomatic unless it becomes infected.
Endoscopic surgery of the pleural cavity performed with visualization via video transmission.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Bronchial carcinoma in patients with pre-existing unilateral lung disease. (1/348)

Forty-six cases of primary bronchogenic carcinoma occurring in patients with other unilateral pleuropulmonary diseases were studied. In 37 cases (80-4%) carcinoma developed in the previously healthy lung. All but one squamous-cell carcinoma and all of five undifferentiated small-cell carcinomas developed in the previously healthy lung while 7 of 15 adenocarcinomas were in the lung with impaired ventilation. It is suggested that the bronchial epithelium of the healthy lung is more exposed to exogenous carcinogens than that of the diseased, underventilated lung, resulting in a higher risk of development of squamous-cell and undifferentiated small-cell carcinoma.  (+info)

Genetic alterations in bronchial lavage as a potential marker for individuals with a high risk of developing lung cancer. (2/348)

Using 12 microsatellite markers, we have studied DNAs from the bronchial lavage of 90 individuals who were referred to an early-lung-cancer clinic in the Northwest of England with suspected lung cancer. Genetic alterations were detected in 15 (35%) of 43 patients with lung cancer but also in 11 (23%) of 47 patients with no cytological or radiological evidence of bronchial neoplasia. No significant differences were found between the referring symptoms in any of the second group of individuals with and without genetic alterations. No correlation was found between smoking exposure and loss of heterozygosity (LOH)/microsatellite alterations (MAs) in the microsatellite markers. On comparing LOH with MAs based on cytology review, we found that the prevalent type of alteration in specimens with cytological evidence of malignancy was LOH; in contrast, the individuals with no cytological evidence of malignancy showed a preponderance of MAs (P = 0.01). Our results indicate that a substantial proportion of cells in the bronchial lavage from suspected lung cancer patients carry identifiable genetic alterations. However, the presence of genetic alterations in the bronchial lavage of individuals with no clinical evidence of lung cancer raises the question whether instability is a phenomenon solely associated with cancer or represents a feature of nonneoplastic diseases. Our results suggest that microsatellite PCR-based assays can be developed as tools for the earlier identification of genetic changes in cells exfoliating in the bronchus.  (+info)

Pulmonary malignancies in the immunocompromised patient. (3/348)

Clinicians should be familiar with immunodeficiency-related malignancies, as their incidence is expected to increase further with the rise in the number and survival of immunocompromised patients. The most common malignancies affecting the lungs in those patients are Kaposi's sarcoma, non-Hodgkin's lymphoma and, to a far less extent, Hodgkin's disease and bronchogenic carcinoma. However, their relative frequency depends on the types of immune deficiency, including those due to congenital disorders, AIDS and drug treatments. This review will summarize epidemiological data on the frequency of immmunodeficiency-related malignancies, recent advances on their pathogenesis and current approaches to their diagnosis and treatment in the various immunosuppressed groups.  (+info)

Influence of age on operative mortality and long-term survival after lung resection for bronchogenic carcinoma. (4/348)

The proportion of elderly patients presenting with bronchogenic carcinoma is increasing. To study the impact of age on clinical presentation, management and outcome of patients, the authors have reviewed their clinical experience over the last 20 yrs. Between 1977 and 1996, 1,079 patients underwent thoracotomy for primary lung carcinoma in the authors' institution. Patients were grouped by age at the time of surgery as <60 yrs, 60-69 yrs and > or =70 yrs. Although the mode of clinical presentation was similar between all age groups, patients <60 yrs were more prone to have advanced stage carcinoma at the time of diagnosis. The rates of exploratory thoracotomy and pneumonectomy were higher in patients <70 yrs, whereas lobectomies and lesser resections largely predominated in patients > or =70 yrs. The mortality rate following lobectomy and lesser resection increased from 1.3% in patients <60 yrs to 5.5% in patients > or =60 yrs (p=0.04) and the mortality rate following pneumonectomy increased from 6.5% in patients <60 yrs to 13.7% in patients > or =70 yrs (p=0.24). The specific long-term survival, which included only the patients who died from primary lung carcinoma, was similar in all age groups. Operative mortality and survival rates are acceptable in patients > or =70 yrs. Therefore, age in itself should not constitute a contraindication to surgical lung resection for primary lung carcinoma as long as a careful preoperative assessment is performed to appropriately select surgical candidates.  (+info)

Clinical correlation of hepatic flow studies. (5/348)

In 100 consecutive hepatic flow studies, 84 were read as negative. Of these, 73 (87%) also had negative static images. Knowing the nature of the primary tumor did not definitively aid in predicting whether hepatic meastases would have detectable early flow. Five cases showed early flow without defects seen in the static images. Three of these were probably related to lymphomas or allied disorders with altered flow. Two cases were in individuals with gastric carcinoma who had abdoninal radiation. One extrahepatic tumor was detected in the series.  (+info)

Psoriatic arthritis complicating lung cancer. (6/348)

Psoriatic arthritis is an inflammatory arthritis associated with psoriasis. While an elevated incidence of lung cancer has been observed in patients with RA or psoriasis, there has been no report of psoriatic arthritis associated with lung cancer. We here report the first case of psoriatic arthritis which developed lung cancer. In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.  (+info)

Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. (7/348)

Normal bronchial epithelial cells (NBECs) are at risk for damage from inhaled and endogenous oxidative species and from epoxide metabolites of inhaled polycyclic aromatic hydrocarbons. Epidemiological and in vitro data suggest that interindividual variation in this risk may result from variation in NBEC expression of enzymes that inactivate reactive species by conjugating them to glutathione. Quantitative competitive reverse transcription-PCR was used to measure mRNA levels of glutathione transferases (GSTs) and glutathione peroxidases (GSHPxs) in primary NBECs from subjects with or without bronchogenic carcinoma. Mean expression levels (mRNA/10(3) beta-actin mRNA) in NBECs from 23 subjects without bronchogenic carcinoma compared to those from 11 subjects with bronchogenic carcinoma respectively (in parentheses) were: mGST (26.0, 6.11), GSTM3 (0.29, 0.09), combined GSTM1,2,4,5 (0.98, 0.60), GSTT1 (0.84, 0.76), GSTP1 (287, 110), GSHPx (140, 62.1), and GSHPxA (0.43, 0.34). Levels of GSTP1, GSTM3, and GSHPx were significantly (P < 0.05) lower in NBECs from subjects with bronchogenic carcinoma. Further, the gene expression index formed by multiplying the values for mGST x GSTM3 x GSHPx x GSHPxA x GSTP1 had a sensitivity (90%) and specificity (76%) for detecting NBECs from bronchogenic carcinoma subjects that was better than any individual gene. In cultured NBECs derived from eight individuals without bronchogenic carcinoma and incubated under identical conditions such that environmental effects were minimized, the mean level of expression and degree of interindividual variation for each gene evaluated was less than that observed in primary NBECs. Data from these studies support the hypotheses that (a) interindividual variation in risk for bronchogenic carcinoma results in part from interindividual variation in NBEC expression of antioxidant genes; (b) gene expression indices will better identify individuals at risk for bronchogenic carcinoma than individual gene expression values; and (c) both hereditary and environmental exposures contribute to the level of and interindividual variation in gene expression observed in primary NBECs. Many epidemiological studies have been designed to evaluate risk associated with polymorphisms or gene expression levels of putative susceptibility genes based on measurements in surrogate tissues, such as peripheral blood lymphocytes. Based on data presented here, it will be important to include the assessment of NBECs in future studies. Measurement of antioxidant gene expression in NBECs may identify the 5-10% of individuals at risk for bronchogenic carcinoma. Bronchoscopic sampling of NBECs from smokers and ex-smokers then will allow susceptible individuals to be entered into surveillance and/or chemoprevention studies.  (+info)

Four decades of surgery for bronchogenic carcinoma in one centre. (8/348)

Since the authors' initial experience in the surgical management of bronchogenic carcinoma in 1956, more than 40 years have passed. The purpose of this report was to review the authors' data and compare the results by decade (1956-1966; 1967-1976; 1977-1986; and 1987-1996) in order to assess the changing patterns in bronchogenic carcinoma. A total of 1,597 thoracotomies have been performed. Between the first and last decades of the study, patients' mean age increased from 57 to 63 yrs, the ratio of males to females decreased from 19:1 to 3:1 and the proportion of adenocarcinoma cases increased from 10 to 34%. The operative mortality decreased from 10% in 1967- 1976 to 4% in 1987-1996 and the overall 5-yr survival improved from 27 to 36% during the same period. The rate of lobectomy progressively increased from 32% in 1956-1966 to 61% in 1987-1996, whereas that of pneumonectomy and exploratory thoracotomy decreased from 42 to 28% and from 20 to 4%, respectively. Changing patterns of patient characteristics, histology and type of surgery were associated with a constant improvement in the overall 5-yr survival. This improvement was particularly evident among patients with advanced-stage carcinoma.  (+info)

We investigated the role of interleukin 8 (IL-8) in mediating angiogenesis in human bronchogenic carcinoma. Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. Functional studies that used tissue homogenates of tumors demonstrated the induction of both in vitro endothelial cell chemotaxis and in vivo corneal neovascularization. It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. Our observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies. ...
TY - JOUR. T1 - Bilobectomy for Bronchogenic Carcinoma. AU - Keller, Steven M.. AU - Kaiser, Larry R.. AU - Martini, Nael. PY - 1988/1/1. Y1 - 1988/1/1. N2 - During a 12-year period, bilobectomy was performed on 166 patients for the treatment of primary lung carcinoma: 108 patients (65%) underwent right upper and middle lobectomy, while 58 patients (35%) underwent right middle and lower lobectomy. Indications for bilobectomy were tumor extending across a fissure (45%), absent fissure (21%), endobronchial tumor (14%), extrinsic tumor or nodal invasion of bronchus intermedius (10%), and vascular invasion (5%). Thirty-one patients (19%) suffered 41 perioperative complications, and 7 patients (4.2%) died. Upper and middle lobectomies were not associated with a significantly different morbidity (p , 0.10) or mortality (p , 0.10) when compared with middle and lower lobectomy. The postoperative chest roentgenograms of all patients demonstrated ipsilateral volume loss, and 31 patients were found to have ...
A patient is described with small cell carcinoma of the lung, associated with profound hypophosphataemia and hyponatraemia. Increased phosphate excretion and inappropriately high urine osmolality were observed. The abnormalities are consistent with tumoral hypophosphataemia and inappropriate antidiuresis. These tumour-related metabolic abnormalities have only been described once before with this malignancy.. ...
This is often referred to as bronchogenic carcinoma. It is recognized as being one of the most common complications of asbestos exposure and it invariably causes death. Asbestos induced carcinoma of the lung is one of the most fatal of the common cancers.. 80% of all people who contract bronchogenic carcinoma die within two years of diagnosis being made. It is not necessary for a worker to have asbestosis in order to attribute bronchogenic carcinoma to asbestos exposure. The attribution can be made if there has been sufficient exposure to asbestos dust.. Pleural Mesothelioma ...
Right lung upper lobe apical segment bronchogenic cancer with pleural invasion as well as malignant mediastinal and right hilar metastatic lymphadenopathy and right pleural effusion.
Acinar cell carcinoma of lung|Adenocarcinoma of lung|Adenocarcinoma of lung (disorder)|Adenocarcinoma of lung, stage I|Adenocarcinoma of lung, stage I (finding)|Adenocarcinoma of lung, stage II|Adenocarcinoma of lung, stage II (finding)|Adenocarcinoma of lung, stage III|Adenocarcinoma of lung, stage III (finding)|Adenocarcinoma of lung, stage IV|Adenocarcinoma of lung, stage IV (finding)|Adenoid cystic carcinoma of lung|Adenosquamous carcinoma of lung|Alveolar cell carcinoma|BC - Bronchogenic carcinoma|Basaloid squamous cell carcinoma of lung|Bronchial carcinoma|Bronchiolar adenocarcinoma|Bronchiolar carcinoma|Bronchioloalveolar carcinoma|Bronchioloalveolar carcinoma (disorder)|Bronchioloalveolar carcinoma - disorder|Bronchoalveolar cancer|Bronchogenic carcinoma|CA - Cancer of bronchus|CA - Carcinoma of bronchus|CA - Lung cancer|Cancer of bronchus|Carcinoma of bronchus|Carcinoma of lung|Carcinoma of lung parenchyma|Carcinoma of lung parenchyma (disorder)|Carcinosarcoma of lung|Clear cell squamous cell
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Four-drug combination chemotherapy (methotrexate, cyclophosphamide, hexamethylmelamine, and CCNU) for non-small cell bronchogenic carcinoma: A cancer and leukemia group B study. Journal of Clinical Oncology. 1983 ...
Summary: This review focuses on the cavitary lesions that are encountered in oncology patients, including primary bronchogenic carcinoma, pulmonary metastas...
Traditionally, high technical morbidity and mortality and uncertain long-term survival have been associated with carinal surgery for bronchogenic carcinoma. However, growing evidence exists that judicious indications, meticulous surgery, and also perioperative management can decrease surgical mortal …
Tracheobronchial foreign body (TFB) aspiration is a common occurrence in children compared with adults. Long-standing cases of TFB aspiration during childhood presenting in an adult have rarely been reported. We report the unique case of an endobronchial Playmobil traffic cone that went undetected for 40 years and presented as a suspected bronchogenic carcinoma. This was subsequently removed successfully with flexible bronchoscopy. To our knowledge this is the first case of a TFB that was overlooked this length of time. ...
Background & objective: The histologic distinction of small cell from non-small cell lung carcinoma and correct identification of all subtypes of lung carcinoma are very important in treatment management. The main method for histologic classification of lung tumors is based on morphology. However, in small bronchoscopic biopsies in particular, distinction is very difficult upon morphology alone. The current study aimed at evaluating the utility of a panel of antibodies, consisting of thyroid transcription factor (TTF-1), P63, high molecular weight keratin [HMWK (34βE12)], cytokeratin (CK7), and cluster of differentiation (CD56) for accurate distinction of bronchogenic carcinomas. Methods: Bronchoscopic biopsies of 60 lung carcinoma cases including 20 small cell carcinomas, 20 adenocarcinomas, and 20 squamous cell carcinomas (SCCs) with typical morphologic features were selected. All these cases were immunohistochemically stained for TTF-1, P63, HMWK (34βE12), CK7, and CD56. All immunostained slides
TY - JOUR. T1 - Cisplatin-etoposide induced myocardial infarction in a patient with small cell carcinoma. AU - Katta, Srija. AU - Chauhan, Sheetal. AU - Singh, Ajit. AU - Shetty, Prasad N.. AU - Kareem, Hashir. AU - Devasia, Tom. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Various drugs used to treat cancer cause hemodynamic/physiological changes in various organs of the body. Cardiotoxicity is one of the major side effects. Cardiotoxicity associated with chemotherapy can range from asymptomatic sub-clinical echocardiographic changes to life-threatening events like congestive heart failure or acute coronary syndrome. We present a case of cisplatin and etoposide-induced myocardial infarction (MI) during the second cycle of chemotherapy for bronchogenic carcinoma of the left lung (small cell carcinoma). The patient developed troponin positive NSTEMI and was managed conservatively. Here, the possible mechanism of action and the importance of cardiac screening while using cisplatin and etoposide are ...
Although the lung is not usually considered a major target organ of sex hormones, epidemiological observations, studies of pulmonary neoplasms in laboratory animals, and investigations of carcinomas derived from other nontarget organs suggest that sex hormones may have a role in the pathogenesis of bronchogenic carcinoma. To confirm that estrogen (ER) and progesterone receptors are present in human lung cancers, 19 resected lung cancers were examined for receptors using a prelabeled sucrose gradient method. Three squamous cell carcinomas were positive for ER (,6.9 fmol/mg cytosol protein). Three squamous cell carcinomas, two adenocarcinomas, and one small cell carcinoma were positive for progesterone receptors (,6.9 fmol/mg cytosol protein). One tumor, a squamous cell carcinoma arising in a woman who smoked, had an ER level of 301 fmol/mg, a highly positive level even for breast cancers. These observations may provide a basis for adjuvant hormonal therapy in selected lung cancer ...
The proportion of elderly patients presenting with bronchogenic carcinoma is increasing. To study the impact of age on clinical presentation, management and outcome of patients, the authors have reviewed their clinical experience over the last 20 yrs. Between 1977 and 1996, 1,079 patients underwent thoracotomy for primary lung carcinoma in the authors institution. Patients were grouped by age at the time of surgery as ,60 yrs, 60-69 yrs and , or =70 yrs. Although the mode of clinical presentation was similar between all age groups, patients ,60 yrs were more prone to have advanced stage carcinoma at the time of diagnosis. The rates of exploratory thoracotomy and pneumonectomy were higher in patients ,70 yrs, whereas lobectomies and lesser resections largely predominated in patients , or =70 yrs. The mortality rate following lobectomy and lesser resection increased from 1.3% in patients ,60 yrs to 5.5% in patients , or =60 yrs (p=0.04) and the mortality rate following pneumonectomy increased ...
Despite extensive research, the role of the commonly employed tumour markers in the diagnosis of lung carcinoma is yet to be clarified. The utility of a new marker, CYFRA 21-1, in the preoperative evaluation of patients with bronchogenic carcinoma was investigated. CYFRA 21-1 was determined with a radiometric assay in serum of 280 patients with lung cancer and 208 patients with various nonmalignant lung diseases. The levels of the marker were significantly higher in lung cancer patients. Among benign lung diseases, elevated CYFRA 21-1 levels were found in pulmonary fibrosis. Using a cut-off of 3.2 ng.ml-1 (95th percentile of levels obtained in benign lung disease), the total sensitivity of the marker was 48%. The best sensitivity was obtained in squamous cell lung cancer (60%). The highest values of CYFRA 21-1 were found in metastatic lung cancer, and the marker sensitivity was more elevated in stage IIIb and IV. On the other hand, 40% of patients with surgically resectable lung cancer had CYFRA ...
The subject of malignant disease of the lung, particularly bronchogenic carcinoma, appears to be a suitable one for such an occasion as this for many reasons. It is a condition of considerable importance owing to its increasing incidence; it clearly illustrates the advance in diagnosis and treatment in chest disease obtained during the last 20 years. It affords, in all its various aspects, opportunities to all sections of this association for study, and, lastly, it is a subject which has always been of considerable interest to me personally (excerpt from A Tudor Edwards).1. Above the readers of todays Thorax will find the introduction to the first article ever published in this journal. The article was written by A Tudor Edwards and is based upon his presidential address to the association for the study of diseases of the chest on 27 July 1945. Despite the fact that this address was given 60 years ago and about 2 months after VE day celebrations signalling the end of World War II, it could just ...
There was no mortality, serious complications or transfusion.. Conclusion. Mediastinoscopy allows accurate information from biopsies of lymph nodes. In our series, the majority (68.2%) showed non-malignant granulomatous diseases, predominantly TB 29.5%, sarcoidosis 14.8%, and concurrent sarcoidosis and TB 12.5%. In the West, 83% are diagnosed with malignancy, of which 81% have lung cancer.2 TB is now uncommon in the West. Pakistan ranks 6th in the estimated global TB burden list, with an incidence of 181/100000, and prevalence 359/100000.4. Sarcoidosis is a diagnostic challenge in countries where TB is endemic.5 The estimated prevalence of sarcoidosis in this series was 27%, which seems higher than the West (12%).2 A series from India reports 18%.1 In our study, the prevalence of bronchogenic carcinoma was 24% and lymphoma 4.5%. Eight (33.3%) of these had N0 and N1 disease and underwent resection of the primary tumours. Thirteen (61.9%) were diagnosed with N2 or N3 disease and were spared a ...
1. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. eds. Introduction and historical overview. In: Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. eds. AJCC Cancer Staging Manual. 7th ed., 2010, Springer; p. xiii.. 2. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997; 111 (6): 1710-1717.. 3. Sobin LH, Wittekind C eds. Lung and pleural tumours. In: Sobin LH, Wittekind C eds. UICC International Union Against Cancer, TNM classification of malignant tumours, 6th ed. New York: Wiley-Liss, 2002; pp. 97-107.. 4. Naruke T, Tsuchiya R, Kondo H, Asamura H. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM staging classification: the Japanese experience. Ann Thorac Surg 2001; 71(6): 1759-1764.. 5. Ginsberg RJ. Continuing controversies in staging NSCLC: an analysis of the revised 1997 staging system. Oncology (Williston Park) 1998; 12 (1 Suppl 2): 51-54.. 6. Paci M, Sgarbi G, Ferrari G, De Franco S, Annessi ...
Belongs to a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in the body. To be more effective it is sometimes used in combination with other chemotherapy medications. Used to treat lymphomas, multiple myeloma, leukemias, mycosis fungoides, neuroblastoma, ovarian carcinoma, retinoblastoma, breast cancer, Ewings sarcoma, bronchogenic carcinoma, small cell lung carcinoma, and other types of cancer. Also known as Cytoxan.
SCLC accounts for approximately 15% of bronchogenic carcinomas. At the time of diagnosis, approximately 30% of patients with SCLC will have tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes. These patients are designated as having limited-stage disease (LD).[1] Patients...
Fig. 11. Routine control of an 82-year-old man after surgery for carcinoma of the larynx ten years ago. PA view shows abnormal right hilum and blurring of the left cardiac contour (A, arrow). Lateral view shows marked forward displacement of the left major fissure (B, arrows) indicating severe LUL collapse, confirmed to be due to bronchogenic carcinoma.. In conclusion, the following areas should be investigated in the lateral view:. The anterior clear space, to evaluate lesions that are not visible in the PA radiograph, the most common being anterior mediastinal masses.. The posterior clear space; the most frequent abnormality in this area is pleural effusion.. The retrocardiac space; Hiatal hernia is the most common finding.. The lung fissures, to detect displacement that may herald the presence of a central carcinoma.. Next time, Ill finish with the checklists.. ...
A patient with watery diarrhea syndrome secondary to bronchogenic carcinoma responded to treatment with clonidine and lidamidine. Stool weight decreased to 43% and 53% of control on two separate trials of clonidine. Stool weight decreased to 35% of control during a trial of lidamidine. Both clonidine and lidamidine increased sodium and chloride absorption in vitro in human intestine. Clonidine, lidamidine, or drugs that are structurally similar may become therapeutic choices for secretory diarrhea. ...
28 late cases of malignancy of all pathologically proven were evaluated. Among them are one case of melanoma, two cases of non-Hodgkin lymphoma (NHL), twenty cases of gastro-intestinal cancers, three cases of bronchogenic carcinoma, one case each of primary hepatocellular carcinoma and multiple peritoneal malignancies of unknown origin respectively.. ,Click Here for Detail,. ...
Introduction Overall, colorectal cancer ranks second only to bronchogenic carcinoma among the cancer killers. Adenocarcinomas constitute the vast majority of colorectal cancers and represent 70% of all malignancies arising in the gastrointestinal tract.
A 32 year old female life long non-smoker with a history of mild asthma, previously well ... Bronchogenic carcinoma D) Atelectasis E) Lung abcess
SIADH. Alexander Usorov, MD July 31, 2007. SIADH. Most frequent cause of hyponatremia First described by Schwartz et al in 1957 in 2 pts with bronchogenic carcinoma Arginine vasopressin was then identified. ADH. Synthesized in hypothalamus Transported down to posterior pituitary...
Characteristics of the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery II (GCCB-S-II) and global description of their ...
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Eloise Mikkonen from the University of Tampere, Finland, is part of a collaborative project investigating a connection between herpes simplex virus and Alzheimers disease. Thanks to a Travelling Fellowship from DMM, she visited her collaborators in Umeå University, Sweden, and the team have now published their work in DMM. Read more on her story here.. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 23 February 2018. Apply now!. Did you know that DMM also offers conference travel grants? Apply by 9 March 2018. Find out more here.. ...
SCLC represents approximately 15% to 20% of all bronchogenic malignancies and is biologically and clinically distinct from non-small cell types. Despite a good initial response to chemotherapy, most SCLC patients ultimately develop resistance and relapse. Because available therapies have little effect on survival, new therapeutic approaches are needed (28, 29). Epigenetic changes, such as DNA methylation and histone acetylation, have a central role in the control of gene transcription and are early events in lung tumorigenesis (1, 26, 30, 31). 5-AZA-dC and HDAC inhibitors can reactivate aberrantly hypermethylated or acetylated genes, thereby inhibiting tumor cells by inducing apoptosis, cell cycle arrest, and differentiation (32-35). In addition to its demethylating function, 5-AZA-dC may also play an antineoplastic role that is methylation independent (36, 37).. HDAC inhibitors alone inhibited growth in four of nine SCLC cell lines, whereas 5-AZA-dC alone inhibited growth in two cell lines ...
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Thirty-two patients with inappropriate secretion of antidiuretic hormone (ADH) complicating small-cell carcinoma of the bronchus were identified from a total of 226 patients with small-cell carcinoma of the bronchus treated at the Christie Hospital, Manchester, between 1978 and 1984. Basic data were collected from patients files concerning the extent of the tumour, symptoms of inappopriate secretion of antidiuretic hormone, biochemical findings, treatment, the course of the inappropriate secretion of ADH and that of the underlying tumour. The data were then analysed and compared with results of previous studies. The response of the inappropriate secretion of ADH to treatment was found to be a significant prognostic factor. Further data were collected to determine the reason for this but it was difficult to drawn any firm conclusions. ...
TY - JOUR. T1 - Lung function following upper sleeve lobectomy for bronchogenic carcinoma. AU - Brusasco, Vito. AU - Ratto, Giovanni B.. AU - Crimi, Paolo. AU - Sacco, Andrea. AU - Motta, Giovanni. PY - 1988. Y1 - 1988. N2 - Eight patients who underwent upper sleeve lobectomy and six who underwent upper simple lobectomy for lung cancer were studied. The two groups were matched for age and preoperative lung function as assessed by standard spirometry. Post-operative lung function studies, including measurements of regional ventilation (V·r) and perfusion (Q·r) by 133 Xenon technique showed that: 1) two weeks after surgery, forced expiratory volume at 1 s was more reduced after simple than after sleeve lobectomy, but in both groups V·r and its vertical gradient were similarly reduced in the operated lung compared to the contralateral; 2) one year after sleeve lobectomy, the vertical gradient of V·r tended to disappear in both lungs while V·r and V·r/Q·r of the operated side increased ...
Looking for online definition of bronchogenic cancer in the Medical Dictionary? bronchogenic cancer explanation free. What is bronchogenic cancer? Meaning of bronchogenic cancer medical term. What does bronchogenic cancer mean?
Definitive histology of the specimen was infiltrating colloid adenocarcinoma with immunophenotype of enteric adenocarcinoma arising from a benign cystic mucoid lesion compatible with bronchogenic cyst. Immunohistochemical staining was positive for cytokinin 20 and CDX 2, and negative for cytokinin 20 and TTF1. Mediastinal lymph nodes were not affected.. The final diagnosis was enteric adenocarcinoma arising from a bronchogenic cyst. No additional lesions were found on colonoscopy and further abdominal exams. Because no signs of disease dissemination were found, no additional therapy was applied. The patient is alive without recurrence of disease 6 months after the surgery.. Bronchogenic cysts are congenital lesions thought to originate from the primitive ventral foregut,2 and are the result of abnormal budding that pinches off from the tracheal tree in the stage when bronchial buds develop into the primitive of respiratory tree.9,10 Bronchogenic cysts are relatively rare, with a prevalence of ...
TY - JOUR. T1 - Supradiaphragmatic bronchogenic cyst extending into the retroperitoneum. AU - Jo, Won-Min. AU - Shin, Jae Seung. AU - Lee, In Sung. PY - 2006/1/1. Y1 - 2006/1/1. N2 - We experienced a case of bronchogenic cyst located on the left lower pleural space extending into the retroperitoneum in a 33-year-old man with left chest pain. Preoperative imaging studies and operative findings showed a broad-based cystic mass on the left lower posterior pleura and diaphragmatic pleura extending into the retroperitoneal region across the diaphragm. Histologic studies proved this mass to be a bronchogenic cyst.. AB - We experienced a case of bronchogenic cyst located on the left lower pleural space extending into the retroperitoneum in a 33-year-old man with left chest pain. Preoperative imaging studies and operative findings showed a broad-based cystic mass on the left lower posterior pleura and diaphragmatic pleura extending into the retroperitoneal region across the diaphragm. Histologic studies ...
Do You Have Bronchogenic Cyst? Join friendly people sharing true stories in the I Have Bronchogenic Cyst group. Find support forums, advice and chat with groups who share this life experience. A Bronchogenic Cyst anonymous support group with informat...
Pancoast tumour, otherwise known as superior sulcus tumour, refers to a relatively uncommon situation where a primary bronchogenic carcinoma arises in the lung apex at the superior pulmonary sulcus and invades the surrounding soft tissues. Termi...
Bronchogenic cysts are rare congenital anomalies that arise in early gestation as a result of abnormal budding of the developing respiratory system.1 Abnormal bronchi or bronchioles may form large saccular structures that may later form cystic lesions. Bronchogenic cysts predominantly occur in males and are often solitary and rarely multiple. Typically, bronchogenic cysts have ciliated epithelium with cartilage, smooth muscles, and mucus-producing bronchial glands similar to the bronchial walls. Bronchogenic cysts do not have alveolar structures because the abnormal budding occurs before the formation of the alveoli. Their location varies and depends on the embryonic stage of development at which the abnormality happens. Intrathoracic bronchogenic cysts have 2 radiographic classifications based on location: mediastinal and intrapulmonary. Mediastinal bronchogenic cysts account for approximately 20% of all primary mediastinal masses.2 Mediastinal bronchogenic cysts appear as smooth, rounded, ...
Bronchogenic cysts are small, solitary cysts or sinuses, most typically located in the region of the suprasternal notch or over the manubrium. Bronchogenic cysts are formed in the 6th week of gestation from an abnormal budding of the tracheal diverticulum. They are lined by respiratory type (ciliated) epithelium, which is characterized by cilia. Histologically these are also composed of cartilage, smooth muscle, fibrous tissue and mucous glands. These cysts originate from the ventral foregut that forms the respiratory system. These cysts are located close to the trachea or main stem bronchi. Rarely there is communication of the cyst with the tracheobronchial tree. These cysts are found most often in young adults and are rare in infancy. The usual symptoms are the result of compression by the cyst, e.g., difficulty breathing or swallowing, cough, and chest pain. Malignant degeneration has been reported in these cysts on rare occasions. Chest x-rays show a smooth density just in front of the ...
Mediastinal bronchogenic cysts are encountered relatively often, but in many cases, diagnosis using imaging modalities, is difficult. Early surgical excision of bronchogenic cysts is recommended as a...
Retroperitoneal bronchogenic cysts (BC) are rare clinical entities and may mimic an adrenal mass. Laparoscopic and retroperitoneoscopic approach is widely-used in adrenal surgery. However minimally- invasive resection of a periadrenally located BC has been reported rarely. Material and methods. A systematic review of PubMed has been performed using the following search strategy: bronchogenic cyst AND (adrenal OR retroperitoneal OR subdiaphragmatic). 18 BC being removed via minimally invasive approach have been found. Including our own case 7 were removed retroperitoneoscopically and 12 laparoscopically. Results. An index case of a 50 year old male is presented. CT revealed 2 masses above the left adrenal area. A control demonstrated an increase in size. Retroperitoneoscopic resection was performed. Pathologic finding showed a multilocular cystic lesion with a diameter of 4cm. The cysts were lined by pseudostratified ciliated epithelium. The wall contained hyaline cartilage, seromucous glands and ...
The mucoepidermoid carcinoma is a rare tumor arising in the bronchial submucosal glands that shows an intimate admixture of glandular elements and sheets of cells with little or no definite squamous differentiation. The low grade mucoepidermoid carcinoma is a characteristic and readily recognized tumor. The very rare high grade mucoepidermoid carcinoma must be distinguished with care from the much more common adenosquamous bronchogenic carcinoma. The present case was a 45-year-old female patient with a several-year history of right chest pain and a few-day-history of coughing, fever, dyspnea. Under the bronchoscopic impression of the bronchial adenoma, right middle and lower lobectomy was done. Grossly, the endobronchial mass, 1.2×1.2cm, was located at the mainsterm bronchus branching to middle and lower lobe. It was well circumscribed. It occluded most of the bronchus supplying the lower lobe. The cut surface was whitish gray, relatively smooth and firm. Microscopically, the tumor consisted ...
Thirty-two patients who presented with haemoptysis and in whom a chest radiograph showed no suggestion of a tumour are reviewed. Six had bronchogenic carcinoma diagnosed� by bronchoscopy and I had an adenoid cystic tumour of the trachea.
Background: Arsenicosis is a multisystem disorder that may affect virtually every organs of the body. The lung involvement in arsenicosis includes bronchitis, obstructive airway disease, bronchiectasis, diffuse parenchymal lung disease and bronchogenic carcinoma.. Objective: To report a rare case of arsenicosis causing bilateral bronchiectasis in a nine year old girl.. Presentation of Case: We describe a 9-year-old girl, who developed bilateral bronchiectasis in association with chronic arsenicosis caused by long-term consumption of homeopathic medicines for drug-resistant epilepsy. To the best of our knowledge, only few cases of bronchiectasis in connection with confirmed arsenicosis has been reported.. ...
Although the use of asbestos has been banned in most industrialized countries, it is still a major public health concern. Asbestos fibers are mutagenic and carcinogenic for humans, classified as carcinogen category 1 (T, R45: can cause the cancer) in the 25th adaptation of the directive 67/548/EEC. In France, asbestos is thought to be responsible each year for many pulmonary diseases: pleural plaque, bronchogenic carcinoma and mesothelioma (malignant tumor of pleura). In order to better understand the transformation process of pleural cells, we compared the gene expression of mesothelium cells (Met-5A) and mesothelioma cells (MSTO-211H) using high-density filter array (588 genes) and microarray (6.969 genes). Results of both technologies were compared and expression levels of several genes were confirmed by quantitative RT-PCR. Data analysis with GemtoolsTM 2.4 software allows us hierarchical classification of genes of known functions by enzyme, function and pathway clusters and leads to ...
Trade Name: Mustargen®. How is this drug used? Mechlorethamine is FDA approved for the treatment of advanced Hodgkins disease, lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, bronchogenic carcinoma, and metastatic cancer resulting in effusion. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Mechlorethamine belongs to a group of drugs called alkylating agents. Alkylating agents produce their anti-cancer effects by causing a chemical reaction that damages the DNA in a cell. The chemical reaction, called interstrand cross-linking, inhibits the cancer cell to grow or replicate and/or ultimately causes cellular death.. How is ...
There is preliminary evidence linking waterpipe use to disease, though this research is made difficult by the fact that many waterpipe users also smoke cigarettes24,27,66 and/or engage in other behaviours that may increase cancer risk.67 Waterpipe use likely increases the risk of bronchogenic carcinoma,68 as well as lung,16,20,69 oral,8 and bladder21,70 cancers. The notion that waterpipe use is associated with cancer is not surprising, given that, like cigarette tobacco, the tobacco used in waterpipes contains tobacco specific nitrosamines,71 and that waterpipe extract produces degeneration and hyperkeratosis in rat mucosa.72 Moreover, in a study comparing 35 healthy waterpipe users with 35 healthy, non-exposed controls, waterpipe use was associated with a significant increase in frequency of chromosomal aberrations and sister chromatid exchanges.63 While the sample size was low, there were obvious trends toward a dose dependent relation on these outcome measures when the data were analysed ...
There is preliminary evidence linking waterpipe use to disease, though this research is made difficult by the fact that many waterpipe users also smoke cigarettes24,27,66 and/or engage in other behaviours that may increase cancer risk.67 Waterpipe use likely increases the risk of bronchogenic carcinoma,68 as well as lung,16,20,69 oral,8 and bladder21,70 cancers. The notion that waterpipe use is associated with cancer is not surprising, given that, like cigarette tobacco, the tobacco used in waterpipes contains tobacco specific nitrosamines,71 and that waterpipe extract produces degeneration and hyperkeratosis in rat mucosa.72 Moreover, in a study comparing 35 healthy waterpipe users with 35 healthy, non-exposed controls, waterpipe use was associated with a significant increase in frequency of chromosomal aberrations and sister chromatid exchanges.63 While the sample size was low, there were obvious trends toward a dose dependent relation on these outcome measures when the data were analysed ...
Photodynamic therapy (PDT) utilizes a combination of sensitizer, visible light and molecular oxygen to generate singlet oxygen and reactive oxygen species (ROS) such as hydrogen peroxide, hydroxyl radical and superoxid anion. Photochemical reactions lead to damage and destruction of cancer cells. The most suitable and effective source of radiation used in PDT is a laser. For this study, a semiconductor laser with output power of 50 mW and 675 nm was selected. In this paper we report a generation of ROS using chloroaluminium disulphonated phthalocyanine (ClAlPcS2) in A549 bronchogenic carcinoma cell line after PDT in vitro. Phthalocyanines, belonging to a new generation of substances for PDT, exhibit effective tissue penetration because of their proper light absorption region, chemical stability and photodynamic stability. The fluorescence measurement with molecular probes, CM-H2DCFDA and Amplex Red, was performed for detection of ROS generation and hydrogen peroxide release from cells. Our ...
A bronchogenic cyst is an inherited condition in which a person has a cyst in the central area of his or her chest cavity, which...
Sep 18, 2018 - Find best Cardiothoracic Surgeons for Bronchogenic Cyst / Mass near you & make an appointment online instantly! Bronchogenic Cyst / Mass appointments are guaranteed and free!
The video shows laparoscopic enucleation of a bronchogenic cyst of esophagus with endoscopic evaluation. There is discussion in the end. Video by Pablo Omelanczuk,
PRIMARY OBJECTIVES:. I. To determine maximally tolerated light dose (MTID). Identify systemic and normal tissue toxicity using 2-[hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) for photodynamic therapy in patients with bronchogenic carcinoma-in-situ (CIS) or microinvasive carcinoma.. SECONDARY OBJECTIVES:. I. To study tumor response in patients with bronchogenic carcinoma-in-situ (CIS) or bronchogenic microinvasive carcinoma.. OUTLINE: This is a dose-escalation study.. Patients receive HPPH intravenously (IV) over 1 hour on day 1. Patients then photodynamic therapy with laser light on day 3. Patients also undergo therapeutic bronchoscopy for endoscopic debridement on day 5.. After completion of study treatment, patients are followed up at 4-6 weeks, 6 months, and then periodically for at least 2 years. ...
A bronchogenic cyst is congenital malformation of the foregut which was generally encountered within the mediastinum and detected in pediatric patients with symptoms of infection or compression on vital structures. They are rarely detected in adult population as a neck mass. We have recently experienced one case of bronchogenic cyst as a parathyroid mass in a 50-year-old female. It was incidentally detected by routine neck ultrasonography and interpreted as a parathyroid cyst with hemorrhage preoperatively, but confirmed as a bronchogenic cyst at pathologic examination. We report this case with review of literatures ...
Shorthouse, A J.; Smyth, J F.; Peckham, M J.; and Steel, G G., Comparison of the chemosensitivity of bronchial carcinoma xenografts with donor patients. Abstr. (1980). Subject Strain Bibliography 1980. 1141 ...
The co-incidence of synchronous intraepithelial neoplasia and early stage invasive lung cancer is not a rare phenomenon. The need for curative treatment and the invasive potential of squamous cell pulmonary carcinoma in situ have been a topic of controversy. Surgical resection still remains the treatment of choice. Varieties of endoscopic techniques such as brachytherapy were developed as an alternative to surgery in selected patients. External beam radiation therapy has been used traditionally in combination with endobronchial brachytherapy in the treatment of roentgenographically occult lung cancer, and can be offered for all patients, but is handicapped, because these tumors are radiographically invisible ...
TY - JOUR. T1 - 5-HT2A receptor enhancement of contractile activity of the porcine urothelium and lamina propria. AU - Moro, Christian. AU - Edwards, Lily. AU - Chess-Williams, Russ. N1 - © 2016 The Japanese Urological Association.. PY - 2016/11. Y1 - 2016/11. N2 - OBJECTIVES: To examine the effect of 5-hydroxytryptamine (5-HT; serotonin) on the contractile properties of the urothelium and lamina propria, as a better understanding of bladder physiology might aid the development of new treatments.METHODS: Strips of porcine urothelium and lamina propria were suspended in gassed Krebs-bicarbonate solution, and cumulative concentration-response curves for 5-HT were generated in the absence and presence of 5-HT antagonists, Nω-nitro-l-arginine and indomethacin. Responses to α-methyl-5-HT were also examined.RESULTS: Strips of urothelium/lamina propria developed spontaneous contractions, whereas the addition of 5-HT induced concentration-dependent increases in contractile tone with maximal ...
INTRODUCTION. Nonbacterial endocardial vegetations of a specific morphologic and histologic pattern, and not attributable to other diseases, such as rheumatic fever or lupus erythematosus, have been described under various names. The appellations have usually attempted to denote the authors concept of its pathogenesis. The terms terminal and marantic endocarditis or endocardiosis imply a type of vegetation or valve change that terminates a chronic illness, and that it is a more or less incidental finding of only pathologic interest. There are many examples which do not terminate a long-term illness, such as carcinoma, but which may be seen in more or ...
An 11-month-old boy born of non-consanguineous marriage presented with a cough for 15 days and fever and breathlessness for 3 days. He had similar complaints at the age of 7 months and was hospitalized for same for 10 days and diagnosed as bronchiolitis and treated with IV antibiotics and nebulization. He was again hospitalized at 8 months of age for pneumonia and treated with IV antibiotics for 14 days. At that time, he was ventilated and bronchoalveolar lavage grew Klebsiella pneumoniae. He has had repeated episodes of cough and breathlessness and has been treated with antibiotics and steroids. On examination, the child had severe respiratory distress with decreased air entry on the left side. He was given nebulization, hydrocortisone but continued to develop stridor and difficulty in breathing. The child was then put under ventilator and condition improved. CT chest showed a retrotracheal bronchogenic cyst. The child underwent excision of the bronchogenic cyst and was alright after that ...
Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future ...
Patton MM, McDonald JR, Moersch HJ (1951). "Bronchogenic large cell carcinoma". J Thorac Cardiovasc Surg. 22 (1): 88-93. PMID ... Small-cell carcinoma Squamous cell carcinoma Adenocarcinoma Large-cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... Giant-cell carcinoma of the lung (GCCL) is a rare histological form of large-cell lung carcinoma, a subtype of undifferentiated ... Comparison with other large-cell anaplastic bronchogenic carcinomas". Scand J Thorac Cardiovasc Surg. 13 (3): 343-6. doi: ...
"Results of bronchoplastic procedures for bronchogenic carcinoma". Ann. Surg. 151 (5): 729-40. doi:10.1097/00000658-196005000- ... CT scan showing a Pancoast tumor (labeled as P, non-small cell lung carcinoma, left lung), from a 47-year-old female smoker ...
1977). "Intensive chemotherapy of small cell bronchogenic carcinoma". Cancer Treatment Reports. 61 (3): 349-54. PMID 194691. ... The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are ... Lung cancer, also known as lung carcinoma (since about 98-99% of all lung cancers are carcinomas), is a malignant lung tumor ... Rare subtypes include carcinoid tumors, bronchial gland carcinomas, and sarcomatoid carcinomas. Lung cancer staging is an ...
PMF can be mistaken for bronchogenic carcinoma and vice versa. PMF lesions tend to grow very slowly, so any rapid changes in ...
Ruffini, E (2002). "The significance of intraoperative pleural effusion during surgery for bronchogenic carcinoma". European ... Ovarian carcinomas are common. Fluid produced by the cells can produce ascites which is typical in carcinomatosis, but less ... Fluid can be serous as seen in primary peritoneal carcinoma or mucinous such as found in pseudomyxoma peritonei which is ...
Other causes include chronic kidney failure, hypothyroidism, bronchogenic carcinoma and sarcoidosis. Some women with polycystic ...
"Fatal overdose of zopiclone in an elderly woman with bronchogenic carcinoma". Journal of Forensic Sciences. 46 (5): 1247-1249. ...
In 1947, the Division began investigating bronchogenic carcinoma in the chromate industry. The Division also performed a major ...
5 Wynder EL, Graham EA: Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma: a study of 684 proven cases. ... 6 Announcement of the award of the Lister Medal - Nature 148, 500-500 (25 October 1941). Some Aspects of Bronchogenic Carcinoma ... Some Aspects of Bronchogenic Carcinoma'. His other awards included the gold medal of the Radiological Society of North America ... and William Adams on the first successful removal of a lung for the treatment of bronchogenic carcinoma in 1933. The patient ...
June 1996). "p53 and MDM2 immunostaining in pulmonary blastomas and bronchogenic carcinomas". Hum. Pathol. 27 (6): 542-6. doi: ... A case of combined small cell lung carcinoma featuring components of FA and cells resembling those from carcinoid tumor has ... November 2008). "[Clinicopathologic study of pulmonary adenocarcinoma with features of bronchioloalveolar carcinoma]". Zhonghua ... prognosis of patients with FA as a whole is considered to be better than that of most other forms of non-small cell carcinoma, ...
Tumors that invade adjacent lung tissue may cause pulmonary symptoms that mimic bronchogenic carcinoma. The tumor may break ...
Isselbacher, KJ; Klaus, H; Hardy, HL (November 1955). "Asbestosis and Bronchogenic Carcinoma, Report of One Autopsied Case and ...
December 1982). "The clinical behavior of "mixed" small cell/large cell bronchogenic carcinoma compared to "pure" small cell ... Squamous cell carcinoma Small cell carcinoma Adenocarcinoma Large cell carcinoma Adenosquamous carcinoma Sarcomatoid carcinoma ... combined small cell carcinoma of the lung has been long classified as a subset of small cell carcinoma, and not as a subset of ... and giant cell carcinoma. Giant cell carcinoma components are seen much more commonly in patients who have undergone radiation ...
Louis in 1935, aged 43 years, from bronchogenic carcinoma, a form of lung cancer. The Library of Congress holds a small ...
The Use of the Nitrogen Mustards in the Palliative Treatment of Carcinoma - with Particular Reference to Bronchogenic Carcinoma ...
The Use of the Nitrogen Mustards in the Palliative Treatment of Carcinoma - with Particular Reference to Bronchogenic Carcinoma ...
Bayliss was awarded his MD in 1946, his thesis being on the subject of cardiac metastases from bronchogenic carcinoma. He ...
However, studies have demonstrated that pleural plaques are an independent risk factor for developing bronchogenic carcinoma ...
Thus, researchers concluded that smoking is responsible for the onset of bronchogenic carcinoma, but did not establish a causal ... This study was a retrospective, case-control study that compared smoking habits of 684 individuals with bronchogenic carcinoma ... of men with bronchogenic carcinoma were heavy to chain smokers, compared to 73.7% of the general population. Statistically, it ... those with bronchogenic carcinoma, and controls, those without the condition. There were 605 microscopic confirmations of the ...
A phase II trial on the effect of Edelfosine on advanced non-small-cell bronchogenic carcinoma had a "remarkable" "high ... in Advanced Non-Small-Cell Bronchogenic Carcinoma". Onkologie. 15 (5): 375-382. doi:10.1159/000217391. Houlihan, WJ; Lohmeyer M ... Among them a phase I trials with solid tumors or leukemias and phase II with non-small-cell lung carcinomas (NSCLC). In a Phase ... Shafer, SH; Williams CL (2003). "Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to ...
... with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma ...
... in advanced bronchogenic carcinoma". Cancer Letters. 1 (2): 97-102. doi:10.1016/S0304-3835(75)95630-X. PMID 65213. Guo Y, Lu JJ ... and epidermoid carcinoma of the lung. It has however not shown desired results as an antineoplastic drug and thus has never ...
... a search for signs of bronchogenic carcinoma (or other causes of clubbing) might still be indicated. A congenital form has also ...
On chest X-ray, hilar enlargement can be due to lymphadenopathy and tumours (tuberculosis, bronchogenic carcinoma, lymphoma, ...
... although tuberculosis and bronchogenic carcinoma may spread from one segment to another. Visualising the interior of the ...
... and bronchogenic carcinoma Mechlorethamine is often administered intravenously, but when compounded into a topical formulation ...
... syndromes Muscular dystrophy disorders Myasthenia gravis Osteogenesis imperfecta Paget's disease Asthma Bronchogenic carcinoma ... Carcinoma and sites of primary lesions Blood Leukemia Lymphoma Breast Colon Kidney Lung Genital organs Ovary or cervix Testis ...
... carcinoma, bronchogenic MeSH C08.381.540.145 - carcinoma, non-small-cell lung MeSH C08.381.540.147 - carcinoma, small cell MeSH ... carcinoma, bronchogenic MeSH C08.785.520.145 - carcinoma, non-small-cell lung MeSH C08.785.520.147 - carcinoma, small cell MeSH ...
1967 - Jack Ruby died of a pulmonary embolism, secondary to bronchogenic carcinoma (lung cancer), on January 3, 1967 at ...
"Tobacco Smoking as a Possible Etiological Factor in Bronchogenic Carcinoma: A Study of Six Hundred and Eighty-Four Proved Cases ...
... primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma of the skin) ... Bronchogenic cyst Capillary hemangioma (infantile hemangioma, nevus maternus, strawberry hemangioma, strawberry nevus) ... Microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) Micronodular basal cell carcinoma Milia en plaque Milium Mixed ... Polypoid basal cell carcinoma Pore-like basal cell carcinoma Primary cutaneous adenoid cystic carcinoma Proliferating ...
... carcinoma, bronchogenic MeSH C04.588.894.797.520.230 - carcinoma, non-small-cell lung MeSH C04.588.894.797.520.235 - carcinoma ... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ... carcinoma, medullary MeSH C04.557.465.625.650.240.325 - carcinoma, merkel cell MeSH C04.557.465.625.650.240.390 - carcinoma, ...
Chronic Bronchogenic cyst Bronchopulmonary amyloidosis Bronchopulmonary dysplasia Brown syndrome Brown-Séquard syndrome ... classic form Basal cell carcinoma Basal cell nevus anodontia abnormal bone mineralization Basal ganglia diseases Basan syndrome ...
... with diseases such as Bronchiectasis Tuberculosis Aspergillosis Bronchial carcinoid Bronchogenic squamous cell carcinoma There ...
Click on sagittal image to select slice. Click on thin tickmark to change timepoint, or thick tickmark for overlay. ...
Cutaneous Metastases in Bronchogenic Carcinoma (five Case Reports) ... Tharakaram S, Vyayalakshmi T, Selvaraj A M. Cutaneous Metastases in Bronchogenic Carcinoma (five Case Reports). Indian J ... Five, cases of cutaneous metastases from bronchogenic car are reported for their rartty and clinical interest. In 3 cases the ...
title = "Metastatic bronchogenic carcinoma to the mandible",. author = "Donoff, {R. B.} and T. Albert and Olson, {D. J.} and W ... Donoff RB, Albert T, Olson DJ, Guralnick W. Metastatic bronchogenic carcinoma to the mandible. Journal of virology. 1976 Jan 1; ... Metastatic bronchogenic carcinoma to the mandible. In: Journal of virology. 1976 ; Vol. 20, No. 2. pp. 1007-1011. ... Metastatic bronchogenic carcinoma to the mandible. / Donoff, R. B.; Albert, T.; Olson, D. J. et al. ...
Agrawal Neetu N, Ghogare M S, Bansod Y V. Unusual Presentation of Bronchogenic Carcinoma. Journal of the Association of ...
Bronchogenic carcinoma is one of the most common cancer in men. It usually affects during 50 to 70 years of age. Cigarette ... the small cell bronchogenic carcinomas and the non-small cell bronchogenic carcinomas. The small cell bronchogenic carcinomas ... Bronchogenic Carcinoma (Lung Cancer). 34. Secondary Cancers of the Lung. 35. Carcinoma of the Stomach. 36. Liver Cancer. 37. ... Oral Cancer (Carcinoma of the Cheek, Lips & Tongue). 24. Carcinoma of the Salivary Gland. 25. Carcinoma of the Paranasal Sinus ...
We present a case of pulmonary metastatic paraganglioma in association with in situ bronchogenic carcinoma. The primary tumor ... The metastatic tumor was accidentally found on a chest x-ray and was initially considered as a primary bronchogenic carcinoma. ... We present a case of pulmonary metastatic paraganglioma in association with in situ bronchogenic carcinoma. The primary tumor ...
Bronchogenic carcinoma. Emphysema, Chronic Obstructive Pulmonary Disease. Lung cancer. CYP1A1. GSTM1. NAT1. NAT2. EPHX1. XRCC1 ...
Cerebral amyloid angiopathy (CAA) refers to the deposition of β-amyloid in the media and adventitia of small and mid-sized arteries (and, less frequently, veins) of the cerebral cortex and the leptomeninges. It is a component of any disorder in which amyloid is deposited in the brain, and it is not associated with systemic amyloidosis.
Bronchogenic carcinoma.. *Mesothelioma.. *Pleural-based lung cancer or metastasis to the pleura. ...
Bronchogenic carcinoma or metastatic malignancy * Idiopathic pulmonary fibrosis * Inhalational and intravenous drug use (eg, ...
Bronchogenic Carcinoma see Lung Cancer * Cancer * Cancer Alternative Therapies * Cancer and Pregnancy see Tumors and Pregnancy ...
Carcinoma, Bronchogenic. Bronchial Neoplasms. Neoplasms, Complex and Mixed. Paclitaxel. Albumin-Bound Paclitaxel. Carboplatin. ... Carcinoma. Lung Neoplasms. Carcinoma, Non-Small-Cell Lung. Adenocarcinoma. Adenocarcinoma of Lung. Carcinoma, Adenosquamous. ... Participants with non-melanoma skin cancers or carcinoma in-situ (e.g., breast carcinoma, urothelial carcinoma or cervical ... Advanced Lung Adenocarcinoma Advanced Lung Adenosquamous Carcinoma Advanced Lung Non-Small Cell Carcinoma Metastatic Lung ...
Carcinoma, Bronchogenic. Bronchial Neoplasms. Neuroendocrine Tumors. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal ... Carcinoma. Breast Neoplasms. Carcinoma, Non-Small-Cell Lung. Melanoma. Stomach Neoplasms. Carcinoma, Renal Cell. Triple ... Renal Cell Carcinoma. Non Small Cell Lung Cancer. Urothelial Carcinoma. Triple Negative Breast Cancer. HR+/HER2- Breast Cancer ... Melanoma Renal Cell Carcinoma Non Small Cell Lung Cancer Urothelial Carcinoma Triple Negative Breast Cancer HR+/HER2- Breast ...
Bronchioalveolar Carcinoma. *Bronchogenic Carcinoma. *Clear Cell Adenocarcinoma. *Non-Small Cell Lung Cancer ...
Lung, Thorax, or Respiration: Bronchogenic carcinoma. Tumorigenic: Active as anti-cancer agent. NTIS** PB86-145521/AS. ...
This is a prospective study of 20 patients confirmed histopathologically to have bronchogenic carcinoma, who came for ... From: Role of PET/CT in post-therapeutic assessment of bronchogenic carcinoma ...
SubjectBronchoscopy (‎1)‎Carcinoma, Bronchogenic (‎1)‎Hemoptysis (‎1)‎Lung Neoplasms (‎1)‎... View MoreDate Issued2000 (‎1)‎ ...
Bronchogenic carcinoma cancerous tumor of bronchus. Mesothelioma. cancerous tumor of the mesothelia cells lining lungs. ...
Tobacco smoking as a possible etiologic factor in bronchogenic carcinoma. JAMA 1950;143:329-36. ... Smoking and carcinoma of the lung. Preliminary report. BMJ 1950;ii:739-48. ...
The use of the nitrogen mustards in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma ...
May suggest Bronchogenic Carcinoma. *Labs. * ACE Level is non-specific and not useful ...
The differential diagnosis for a fungal ball in the lung is limited: echinoccocal cyst, necrotizing bronchogenic carcinoma, or ... cavitary bronchogenic carcinoma, and infection by NTM (21,26-30). In many countries, pulmonary TB is the most common disorder ... Cavitating bronchogenic carcinoma may invade the chest wall causing bone destruction or may cause diffuse pleural involvement; ... Cavitary bronchogenic carcinoma is usually associated with adenopathy and often pleural effusion. ...
Histopathologic classification of bronchogenic carcinomas among a cohort of workers occupationally exposed to beryllium. ... bronchogenic type; two were adenocarcinoma, bronchiolar alveolar type; and three were large cell undifferentiated carcinomas. ... In 25 of the cases, the primary site of malignancy was the lung: five of these malignancies were epidermoid carcinomas; nine ... were small cell anaplastic carcinomas; six were adenocarcinoma, ...
Primary bronchogenic carcinoma by inhalation recognised as an occupational disease. Several tables of occupational diseases ... compensate primary bronchogenic carcinoma. Smoking is no obstacle for recognition and compensation. Bookmark ... ...
Bronchogenic carcinoma in chronic obstructive pulmonary disease. JAMA 1976;235:621-622. ... Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma. Oncogene ... COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma. Thorax 2004;59: ... which includes any history of nonmetastatic cancer except basal cell and squamous cell skin carcinoma), neurological disease ...
Bronchogenic carcinoma in Kashmir valley. Indian Journal of Chest Disorders, 1973, 15:285-295. ... Oesophageal and gastric carcinoma in the Republic of Yemen. British Journal of Cancer, 1995, 71:409-410. ...
When an underlying bronchogenic carcinoma is suspected or if any abnormalities are not consistent with the diagnosis of ...
Tests for diagnosis and staging of bronchogenic carcinoma.. Edell, E. S., Jul 1995, In: Current opinion in pulmonary medicine. ... Photodynamic therapy: Its use in the management of bronchogenic carcinoma. Edell, E. S. & Cortese, D. A., Jan 1 1995, In: ... Adjuvant therapy for colon carcinoma: Current status and future directions. Sinicrope, F. A. & Sugarman, S. M., 1994, In: ...

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