Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Basal Cell Nevus Syndrome: Hereditary disorder consisting of multiple basal cell carcinomas, odontogenic keratocysts, and multiple skeletal defects, e.g., frontal and temporoparietal bossing, bifurcated and splayed ribs, kyphoscoliosis, fusion of vertebrae, and cervicothoracic spina bifida. Genetic transmission is autosomal dominant.Skin Neoplasms: Tumors or cancer of the SKIN.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Neoplasms, Basal Cell: Neoplasms composed of cells from the deepest layer of the epidermis. The concept does not refer to neoplasms located in the stratum basale.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Eyelid Neoplasms: Tumors of cancer of the EYELIDS.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Facial NeoplasmsCarcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Mohs Surgery: A surgical technique used primarily in the treatment of skin neoplasms, especially basal cell or squamous cell carcinoma of the skin. This procedure is a microscopically controlled excision of cutaneous tumors either after fixation in vivo or after freezing the tissue. Serial examinations of fresh tissue specimens are most frequently done.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Keratin-14: A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Breast Neoplasms: Tumors or cancer of the human BREAST.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Lung Neoplasms: Tumors or cancer of the LUNG.Mouth Neoplasms: Tumors or cancer of the MOUTH.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Carcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Keratin-5: A type II keratin that is found associated with the KERATIN-14 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-5 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Epidermis: The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)DNA, Neoplasm: DNA present in neoplastic tissue.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Dermoscopy: A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.Keratin-15: A type I keratin found in the basal layer of the adult epidermis and in other stratified epithelia.Keratosis: Any horny growth such as a wart or callus.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Bowen's Disease: A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)Stomach Neoplasms: Tumors or cancer of the STOMACH.Sunlight: Irradiation directly from the sun.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Keratosis, Seborrheic: Benign eccrine poromas that present as multiple oval, brown-to-black plaques, located mostly on the chest and back. The age of onset is usually in the fourth or fifth decade.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Jaw Cysts: Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.Olfactory Mucosa: That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Hedgehog Proteins: A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Keratoacanthoma: A benign, non-neoplastic, usually self-limiting epithelial lesion closely resembling squamous cell carcinoma clinically and histopathologically. It occurs in solitary, multiple, and eruptive forms. The solitary and multiple forms occur on sunlight exposed areas and are identical histologically; they affect primarily white males. The eruptive form usually involves both sexes and appears as a generalized papular eruption.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Carcinoma, Skin Appendage: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Integrin alpha6: An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Tongue Neoplasms: Tumors or cancer of the TONGUE.Chromosomes, Human, Pair 9: A specific pair of GROUP C CHROMSOMES of the human chromosome classification.Carcinoma, Giant Cell: An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)Sebaceous Gland NeoplasmsUrothelium: The epithelial lining of the URINARY TRACT.Lutheran Blood-Group System: A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.RNA, Neoplasm: RNA present in neoplastic tissue.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Vulvar Neoplasms: Tumors or cancer of the VULVA.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Nose Neoplasms: Tumors or cancer of the NOSE.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Prostatic Intraepithelial Neoplasia: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.Stria Vascularis: A layer of stratified EPITHELIUM forming the endolymphatic border of the cochlear duct at the lateral wall of the cochlea. Stria vascularis contains primarily three cell types (marginal, intermediate, and basal), and capillaries. The marginal cells directly facing the ENDOLYMPH are important in producing ion gradients and endochoclear potential.Transplantation, Heterologous: Transplantation between animals of different species.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.Skin Pigmentation: Coloration of the skin.Hair Follicle: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Trachea: The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Betapapillomavirus: A genus of DNA viruses in the family PAPILLOMAVIRIDAE, causing cutaneous lesions in humans. Infections exist in latent form in the general population and are activated under conditions of IMMUNOSUPPRESSION.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Polymorphism, Single-Stranded Conformational: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Esophagus: The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Metaplasia: A condition in which there is a change of one adult cell type to another similar adult cell type.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Epithelium, Corneal: Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Chemoembolization, Therapeutic: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Aminoquinolines: Quinolines substituted in any position by one or more amino groups.Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)Mice, Inbred BALB CMammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Histocytochemistry: Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.Sweat Gland Neoplasms

PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. (1/1029)

By a combination of cDNA library screening, rapid amplification of cDNA ends analysis, and BAC sequencing, a novel human patched-like gene (PTCH2) has been cloned and sequenced. The genomic organization is similar to PTCH1 with 22 exons and, by radiation hybrid mapping, PTCH2 has been localized to chromosome 1p33-34, a region often lost in a variety of tumors. Several alternatively spliced mRNA forms of PTCH2 were identified, including transcripts lacking segments thought to be involved in sonic hedgehog binding and mRNAs with differentially defined 3' terminal exons. In situ hybridization revealed high expression of PTCH2 transcripts in both familial and sporadic basal cell carcinomas in similarity to what has been observed for PTCH1, suggesting a negative regulation of PTCH2 by PTCH1. This finding tightly links PTCH2 with the sonic hedgehog/PTCH signaling pathway, implying that PTCH2 has related, but yet distinct, functions than PTCH1.  (+info)

Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid. (2/1029)

Photodynamic therapy with topically applied delta-aminolaevulinic acid is used to treat skin tumours by employing endogenously formed porphyrins as photosensitizers. This study examines the time course of porphyrin metabolite formation after topical application of delta-aminolaevulinic acid. Porphyrin biosynthesis in human skin tumours (basal cell carcinoma, squamous cell carcinoma), in psoriatic lesions, and in normal skin was investigated. Skin areas were treated with delta-aminolaevulinic acid, and levels of total porphyrins, porphyrin metabolites and proteins were measured in samples excised after 1, 2, 4, 6, 9, 12 and 24 h. There was an increase in porphyrin biosynthesis in all tissues with maximum porphyrin levels in tumours between 2 and 6 h and in psoriatic lesions 6 h after treatment. The pattern of porphyrins showed no significant difference between normal and neoplastic skin, protoporphyrin being the predominant metabolite. The results suggest that optimum irradiation time for superficial epithelial skin tumours may be as soon as 2 h after application of delta-aminolaevulinic acid, whereas for treatment of psoriatic lesions an application time of 6 h is more suitable.  (+info)

A man with a prosthetic ear and multiple pulmonary nodules. (3/1029)

Basal cell carcinoma is generally regarded as a relatively indolent tumor easily controlled with local therapy. When neglected or inadequately treated this tumor can become locally aggressive and in rare circumstances metastasize. This report documents a case of basal cell carcinoma metastatic to the lung that resulted in rapidly progressive respiratory failure and death.  (+info)

Color Doppler sonography of focal lesions of the skin and subcutaneous tissue. (4/1029)

We evaluated with color Doppler sonography 71 visible and palpable nodules of the skin and subcutaneous tissue from 51 patients. The nodules were classified as avascular (type I), hypovascular with a single vascular pole (type II), hypervascular with multiple peripheral poles (type III), and hypervascular with internal vessels (type IV). Of the 32 malignant nodules, 9% showed a type I pattern, 50% had a type III pattern, and 41% had a type IV pattern; of the 39 benign nodules, 86% showed a type I pattern and 14% had a type II pattern. The sensitivity and specificity of hypervascularity in malignant lesions were 90% and 100%, respectively, whereas the sensitivity and specificity of hypovascularity in benign lesions were 100% and 90%, respectively. The authors conclude that color Doppler sonography is able to increase the specificity of ultrasonography in the evaluation of nodular lesions of the skin.  (+info)

Long-term results after surgical basal cell carcinoma excision in the eyelid region. (5/1029)

AIMS: To evaluate the data for patients with basal cell carcinoma (BCC) in the eyelid region, to demonstrate histologically controlled tumour excision, and to prove the efficacy of the treatment on the basis of long term observations. METHODS: Retrospective analysis of 382 microscopically controlled BCC excisions in the eyelid apparatus (350 patients) in a follow up study over 5.7 (SD 1.1) years. Tumour location, tumour size, and histological results were recorded. The same procedure was followed for recurrences. Follow up examinations were carried out 1, 3, 6, and 12 months after the operation, and then annually for a further 4 years or longer. RESULTS: A recurrence rate of 5.36% was observed after the primary operation. 60.3% of first recurrences occurred in the medial canthus, 41.2% showed in depth extension, and sclerosing types were overly represented at 35.3%. After the second operation the recurrence rate increased to 14.7% and reached 50% after a third and fourth operation. CONCLUSIONS: The greatest risk of recurrence exists for BCCs of the medial canthus with in depth extension, and for sclerosing types. The recurrence rate increases after every operation. For high risk cases, consideration should be given to adjuvant treatment such as radiotherapy.  (+info)

The sebaceous nevus: a nevus with deletions of the PTCH gene. (6/1029)

Sebaceous nevi (SN) are congenital malformations of the skin with the potential to develop into basal cell carcinoma (BCC). To date, the molecular basis for their carcinogenic potential remains unknown. The genetic defect in BCC is known and involves the human homologue of Drosophila patched (PTCH) on chromosome 9q22.3. The objective of this study was to test whether allelic deletion of the PTCH gene could already be detected in SN. Twenty-one paraffin-embedded SN were investigated in this study. Basaloid cells in conjunction with mature sebaceous glands as well as epidermal layer apart from SN were microdissected and subjected to single-step DNA extraction. We performed the analysis with polymorphic markers at 9q22.3 (D9S15, D9S252, D9S287, and D9S303). Of the 20 informative SN, 8 (40%) exhibited loss of heterozygosity at least at one locus. Here, we provide the first evidence of the involvement of the tumor suppressor gene PTCH in SN. Whether PTCH deletion in SN is associated with progression to BCC and/or other appendageal tumors should be addressed in future studies.  (+info)

High levels of patched gene mutations in basal-cell carcinomas from patients with xeroderma pigmentosum. (7/1029)

Recently, hptc, a human gene homologous to the Drosophila segment polarity gene patched (ptc), has been implicated in the nevoid basal-cell carcinoma (BCC) syndrome, and somatic mutations of hptc also have been found in sporadic BCCs, the most frequent cancers found in the white population. We have analyzed the hptc gene, postulated to be a tumor suppressor gene, in 22 BCCs from patients with the hyperphotosensitive genodermatosis xeroderma pigmentosum (XP). Patients with XP are deficient in the repair of UV-induced DNA lesions and are characterized by their predisposition to cancers in sun-exposed skin. Analysis using PCR-single-strand conformation polymorphism of the hptc gene identified 19 alterations in 16 of 22 (73%) of the BCCs examined. Only two (11%) deletions of the hptc gene were found in XP BCCs compared with >30% rearrangement observed in non-XP sporadic BCCs, and 17 of 19 (89%) were base substitutions. Among the 17 base substitutions, 11 (65%) were CC --> TT tandem mutations, and 4 (23%) were C --> T substitutions, all targeted at bipyrimidine sites. Hence, a significantly higher number (15 of 19; 79%) of UV-specific alterations are seen in XP tumors, in contrast to non-XP sporadic BCCs. Interestingly, we have found that in 7 of 14 (50%) XP BCCs analyzed, both hptc and the tumor suppressor gene p53 are mutated. Not only have our data indicated the key role played by hptc in the development of BCCs, they also have substantiated the link between unrepaired UV-induced DNA lesions and skin carcinogenesis, as exemplified by the UV-specific alterations of different genes in the same tumors.  (+info)

Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan. (8/1029)

To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinomas (SCC). The result showed that p53 gene mutations were found in 39% of cases with Bowen's disease (9/23), 28.6% of cases with BCC (2/7) and 55.6% of cases with SCC (5/9). Most of the mutation sites were located on exon 5 and exon 8. Moreover, the results from direct sequencing indicated that missense mutations were found at codon 149 (C-->T) in one case, codon 175 (G-->A) in three cases, codon 273 (G-->C) in three cases, codon 292 (T-->A) in one case, codon 283 (G-->T) in one case, codon 172 (T-->C) in one case and codon 284 (C-->A) in one case. In addition, silent mutations were also found in four cases. These mutations were located at codons 174, 253, 289 and 298 respectively. In immunohistochemistry analysis, p53 overexpression was found in 43.5% (10/23) of cases with Bowen's disease, 14% (1/7) of cases with BCC and 44% (4/9) of cases with SSC. These findings showed that p53 gene mutation rate in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan is high and that the mutation types are different from those in UV-induced skin cancers.  (+info)

*Basal-cell carcinoma

Nevoid basal-cell carcinoma syndrome Cystic basal cell carcinoma Micronodular basal cell carcinoma Superficial basal cell ... Cicatricial basal cell carcinoma (also known as "morpheaform basal cell carcinoma," and "morphoeic basal cell carcinoma") is an ... squamous cell carcinoma. In a small proportion of cases, basal cell carcinoma also develops as a result of basal cell nevus ... Pore-like basal cell carcinoma resembles an enlarged pore or stellate pit. Aberrant basal cell carcinoma is characterized by ...

*Nevoid basal-cell carcinoma syndrome

... (NBCCS), also known as basal-cell nevus syndrome, multiple basal-cell carcinoma syndrome, ... Some or all of the following may be seen in someone with Gorlin syndrome:[citation needed] Multiple basal-cell carcinomas of ... About 10% of people with the condition do not develop basal-cell carcinomas (BCCs). The name Gorlin syndrome refers to the ... GeneReviews/NCBI/NIH/UW entry on Nevoid Basal Cell Carcinoma Syndrome GeneReviews/NCBI/NIH/UW entry on 9q22.3 Microdeletion US ...

*Skin cancer

... basal-cell skin cancer (basal-cell carcinoma) (BCC), squamous-cell skin cancer (squamous-cell carcinoma) (SCC) and malignant ... Of nonmelanoma skin cancers, about 80% are basal-cell cancers and 20% squamous-cell skin cancers. Basal-cell and squamous-cell ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... electrodesiccation and curettage can be found in the discussions of basal-cell carcinoma and squamous-cell carcinoma. Mohs' ...

*Mohs surgery

Two isolated studies reported cure rate for primary basal cell carcinoma as low as 95% and 96%. Recurrent basal cell cancer has ... for primary basal cell carcinoma, the most common type of skin cancer. Mohs procedure is also used for squamous cell carcinoma ... Cure rate of 96.6%. 1065 cases of squamous cell carcinoma of face, scalp, and neck - cure rate 94.8% 2075 cases of basal cell ... Cure rate for basal cell cancer of the ear, less than 1 cm, 124 cases, cure rate 100%. Cure rate of basal cell cancer of the ...

*Hughes procedure

Lower Eyelid Reconstruction~treatment at eMedicine "Eyelid Cancer Newport Beach , Basal Cell Carcinoma Orange County , Melanoma ...

*List of OMIM disorder codes

CLCNKA Basal cell carcinoma, somatic; 605462; PTCH1 Basal cell carcinoma, somatic; 605462; PTCH2 Basal cell carcinoma, somatic ... FLCN Renal cell carcinoma; 144700; DIRC2 Renal cell carcinoma; 144700; HNF1A Renal cell carcinoma; 144700; RNF139 Renal cell ... OGG1 Renal cell carcinoma, papillary, 1; 605074; PRCC Renal cell carcinoma, papillary, 1; 605074; TFE3 Renal cell carcinoma, ... T cell-negative, B-cell/natural killer-cell positive; 608971; CD3D Severe combined immunodeficiency, T cell-negative, B-cell/ ...

*PTCH2

Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma ... "Nevoid Basal Cell Carcinoma Syndrome". 1993. PMID 20301330. Li TJ, Sun LS, Luo HY, Yuan JW, Gao L, Gu XM, Li XF, Xu LL (2009 ... "Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome". Familial Cancer. 12 (4): 611-4. doi: ... undergoing alternative splicing and up-regulated in basal cell carcinomas". Cancer Research. 59 (4): 787-92. PMID 10029063. ...

*Sebaceous carcinoma

Histology may mimic basal cell carcinoma. This type of carcinoma is commonly managed by local resection, cryotherapy, topical ... The cell of origin is usually unknown. Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to ... Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor. Most are typically about 10 mm in size at ... Shields JA, Demirci H, Marr BP, Eagle RC, Shields CL (2005). "Sebaceous carcinoma of the ocular region: a review". Surv ...

*Mir-542 microRNA precursor family

"Expression of microRNAs in basal cell carcinoma". British Journal of Dermatology. 167 (4): no. doi:10.1111/j.1365-2133.2012. ... Cell Death and Differentiation. 19 (4): 713-721. doi:10.1038/cdd.2011.143. PMC 3307984 . PMID 22052189. Oneyama, C.; Morii, E ...

*Mir-572 microRNA precursor family

"Expression of microRNAs in basal cell carcinoma". British Journal of Dermatology. 167 (4): no. doi:10.1111/j.1365-2133.2012. ... "MiR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis ...

*Rombo syndrome

Basal cell carcinomas were a frequent complication. The skin atrophy was referred to as vermiculate atrophoderma. Basal cell ... basal cell carcinomas and peripheral vasodilation with cyanosis". Acta Derm. Venereol. 61 (6): 497-503. PMID 6177160. ... peripheral vasodilation with cyanosis and a propensity to develop basal cell carcinomas. The lesions become visible in late ... carcinomas may develop around the age of 35. Histological observations during the early stage include irregularly distributed ...

*Metastasis

Basal cell carcinoma for example rarely metastasizes. When tumor cells metastasize, the new tumor is called a secondary or ... renal cell carcinoma and lung cancer) Collective cell migration Contact normalization Disseminated disease Mouse models of ... Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, ... Several different cell types are critical to tumor growth. In particular, endothelial progenitor cells have been shown to have ...

*Mir-455 microRNA precursor family

"Expression of microRNAs in basal cell carcinoma". British Journal of Dermatology. 167 (4): no. doi:10.1111/j.1365-2133.2012. ... are implicated in acquired temozolomide resistance in glioblastoma multiforme cells". Cancer Letters. 296 (2): 241-248. doi: ... and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells". ...

*Dermatoscopy

Aid in the diagnosis of skin tumors - such as basal cell carcinomas, squamous cell carcinomas, cylindromas, dermatofibromas, ... "Dermoscopic differentiation of a superficial basal cell carcinoma and squamous cell carcinoma in situ". Dermatologic Surgery. ... Examples would be Bowen's disease, superficial basal cell carcinomas, and lentigo malignas. These tumors have very indistinct ... Scalvenzi, M; Lembo, S; Francia, MG; Balato, A (2008). "Dermoscopic patterns of superficial basal cell carcinoma". ...

*Mir-638 microRNA precursor family

"Expression of microRNAs in basal cell carcinoma". British Journal of Dermatology. 167 (4): no. doi:10.1111/j.1365-2133.2012. ... miR-638 has additionally been found to be upregulated in the K562 leukaemic cell line. MicroRNA Lu J, Kwan BC, Lai FM, Tam LS, ... Yang Y, Wang LL, Li YH, Gao XN, Yu L (2011). "[Expression level of miRNA-663 in different leukemic cell lines and its ... miR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs. Thus ...

*Trichoepithelioma

They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal ... Its appearance is similar to basal cell carcinoma. One form has been mapped to chromosome 9p21. Trichoepitheliomas may be ... cell carcinoma. Trichoblastoma Pilomatricoma List of cutaneous conditions List of cutaneous neoplasms associated with systemic ... Trichoepitheliomas consisted of nests of basaloid cells. ...

*Electrodesiccation and curettage

... in situ squamous cell carcinoma) Pyogenic granuloma Actinic keratoses Basal cell carcinoma Keratoacanthoma Skin tags The cure ... Cure rate for nodular basal cell cancer is higher than for infiltrative basal cell cancer. Essentially, all the prognostic ... Barlow, JO; Zalla, MJ; Kyle, A; Dicaudo, DJ; Lim, KK; Yiannias, JA (2006). "Treatment of basal cell carcinoma with curettage ... "Treatment of basal cell carcinoma with curettage alone". Journal of the American Academy of Dermatology. 54 (6): 1039-45. doi: ...

*Frederic E. Mohs

Telfer, N R, Colver, G B and Morton, C A (2008). "Guidelines for the management of basal cell carcinoma". British Journal of ...

*Smoothened

... basal-cell carcinoma, pancreatic cancer, and prostate cancer. As such, SMO is an attractive cancer drug target, along with the ... a smoothened receptor inhibitor for the treatment of basal-cell carcinoma, being investigated for the treatment of other types ... "Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central ... "Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair- ...

*CLPTM1L

"New common variants affecting susceptibility to basal cell carcinoma". Nat. Genet. 41 (8): 909-14. doi:10.1038/ng.412. PMC ... "Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck". Carcinogenesis. 31 (11): ... 2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Can Res ... which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. ...

*Hedgehog signaling pathway

Basal cell carcinoma, the most common form of cancerous malignancy, has the closest association with hedgehog signaling. Loss- ... Diseases associated with the malfunction of this pathway include basal cell carcinoma. The Hedgehog signaling pathway is one of ... Furthermore, overexpression of PTCH2 does not replace mutated PTCH1 in basal cell carcinoma. In invertebrates, just as in ... 2004). "Inhibition of Smoothened Signaling Prevents Ultraviolet B-Induced Basal Cell Carcinomas through Regulation of Fas ...

*Seborrheic keratosis

... including basal cell carcinoma. Sometimes seborrheic keratosis and basal cell carcinoma occur at the same location, and ... "Basal Cell Carcinoma and Seborrheic Keratosis: When Opposites Attract". International Journal of Surgical Pathology. 23 (6): ... basal cell papilloma, or a senile wart, is a non-cancerous (benign) skin tumour that originates from cells in the outer layer ... sometimes seborrheic keratosis progresses to basal cell carcinoma. At clinical examination the differential diagnosis include ...

*Eye neoplasm

The most common eyelid tumor is called basal cell carcinoma. This tumor can grow around the eye but rarely spreads to other ... large cell lymphoma of the B-cell type, although T cell lymphomas have also been described. The most common malignant ... Other types of common eyelid cancers include squamous carcinoma, sebaceous carcinoma and malignant melanoma. The most common ... "Squamous Carcinoma and Intraepithelial Neoplasia of the Conjunctiva - The Eye Cancer Network". Retrieved 2010-03-10. The Tumori ...

*Coramsine

... a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter ... Cormasine is thought to kill tumor cells by direct cell lysis, showing selectivity for cancer cells as opposed to healthy cells ... Food and Drug Administration in the treatment of renal cell carcinoma and for malignant melanoma respectively. 2006 also saw ... the completion of Phase I/IIa trials and the commissioning of Phase IIb trials that would target renal cell carcinoma (stage ...

*Institute for Genetic Engineering and Biotechnology (INGEB), Sarajevo

Analysis of the specific chromosomal markers of basal cell carcinoma; (2007-2009) Financed by the Ministry of Education and ... The most frequently used tests in research projects of this lab are based on cell culture and include: chromosome aberrations ... Primary cell lines establishment. Projects: Analysis of K2(B3O3F4OH) bioactive and medical potential; (ongoing project). ... Participation in international collaborative project: HUMNXL - Exfoliated cells micronucleus project; (2009-2011); ...

*Prostaglandin-endoperoxide synthase 2

Cell Dev. Biol. 17 (5): 544-54. doi:10.1016/j.semcdb.2006.09.001. PMID 17071117. Minghetti L, Pocchiari M (2007). " ... Inhibition of PTGS1 (COX-1) reduces the basal production of cytoprotective PGE2 and PGI2 in the stomach, which may contribute ... "A new cyclo-oxygenase-2 gene variant in the Han Chinese population is associated with an increased risk of gastric carcinoma". ... PTGS2 (COX-2) is unexpressed under normal conditions in most cells, but elevated levels are found during inflammation. PTGS1 ( ...
For patient information click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2] Synonyms and Keywords: Basal cell epithelioma, rodent ulcer, Ronald Reagan tumor, infiltrative basal cell carcinoma, basal-cell cancer,Skin Fibroepithelial Basal Cell Carcinoma, Skin Signet Ring Cell Basal Cell Carcinoma, Skin Sarcomatoid Basal Cell Carcinoma, Superficial Multifocal Basal Cell Carcinoma, Superficial Basal Cell Carcinoma, Skin Basosquamous Cell Carcinoma, Skin Nodular Basal Cell Carcinoma, Skin Morphea-Type (Sclerosing) Basal Cell Carcinoma, Skin Clear Cell Basal Cell Carcinoma, and Skin Adamantinoid Basal Cell Carcinoma ...
OLIVEIRA, Giuliano da Paz; GIRAO, Régio José Santiago; SOARES, Cléverson Teixeira and MELLO JUNIOR, Edgard Jose Franco. Multiple metastatic basal cell carcinoma with concurrent metastatic pleomorphic sarcoma in chronic lymphedema area: case report. An. Bras. Dermatol. [online]. 2012, vol.87, n.6, pp.899-902. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962012000600013.. Chronic lymphedema presents as interstitial fluid retention due to a failure in the lymphatic system drainage. The affected region becomes more vulnerable immunologically and predisposed to the onset of neoplasms. Basal Cell Carcinoma is the most common sort of neoplasm, nevertheless it rarely metastisizes. Sarcomas are malignant mesenchymal neoplasms, locally aggressive, which can spread. Here is reported an infrequent case of multiple basal cell carcinoma, synchronous to a poorly differentiated pleomorphic sarcoma, both spreading to lymph nodes and arising from tissue compromised by chronic lymphedema.. Keywords : ...
What Basil Cell Skin Cancer Does Skin Cancer Look Like Basal Cell Carcinoma Youtube They Ask How I Do It Was Unaware. This awesome photo collections about What Basil Cell Skin Cancer Does Skin Cancer Look Like Basal Cell Carcinoma Youtube They Ask How I Do It Was Unaware is available to download. We collect this awesome photo from internet and choose the best for you. What Basil Cell Skin Cancer Does Skin Cancer Look Like Basal Cell Carcinoma Youtube They Ask How I Do It Was Unaware photos and pictures collection that posted here was carefully selected and uploaded by Rockymage team after choosing the ones that are best among the others. So, finally we make it and here these list of awesome photo for your inspiration and informational purpose regarding the What Basil Cell Skin Cancer Does Skin Cancer Look Like Basal Cell Carcinoma Youtube They Ask How I Do It Was Unaware as part of tommycat.info exclusive updates collection.What Basil Cell Skin Cancer Does Skin Cancer Look Like Basal Cell ...
Basal cell carcinoma is a slow growing non-melanoma skin cancer. It is thought to be caused by over exposure to the harmful ultraviolet (UV) rays of the sun. It can be highly disfiguring if allowed to grow, but almost never spreads beyond the original tumor site. Only in rare cases can basal cell carcinoma spread to other parts of the body and become life-threatening. This disease should be treated promptly due to its ability to destroy tissue in the areas that it infiltrates.. What do basal cell carcinomas look like?. Basal cell carcinomas are abnormal, uncontrolled growths or lesions that arise in the skins basal cells, which line the deepest layer of the outermost layer of the skin, known as the epidermis. Basal cell carcinomas often look like open sores, red patches, pink growths, shiny bumps, or scars.. What are the consequences of basal cell carcinomas?. Basal cell carcinomas will continue to grow locally, bleed, and destroy tissue unless treated. Serious problems can arise if the skin ...
Salto-Tellez, M., Chong, P.Y., Soong, R., Peh, B.K., Ito, K., Han, H.C., Tada, K., Ito, Y., Tan, S.H., Ong, W.Y., Voon, D.C. (2006). RUNX3 protein is overexpressed in human basal cell carcinomas. Oncogene 25 (58) : 7646-7649. [email protected] Repository. https://doi.org/10.1038/sj.onc. ...
Conditions: Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent ...
Objectives: To evaluate the safety of two applications of PEP005 (ingenol mebutate) gel in superficial basal cell carcinoma. Efficacy was a secondary end-point. Methods: Randomized, vehicle-controlled, phase IIa study conducted at eight private dermatology clinics in Australia. A total of 60 patients with histologically confirmed superficial basal cell carcinoma (lesion size, 4-15 mm) were randomized to treatment on days 1 and 2 (Arm A) or days 1 and 8 (Arm B) and, within each arm, to ingenol mebutate gel, 0.0025%, 0.01% or 0.05%, or vehicle gel. The main outcome measures were the incidence and severity of adverse events and local skin responses in Arms A and B; lesion clearance at day 85 was a secondary measure. Results: The incidence of adverse events was low. One patient treated with ingenol mebutate gel, 0.05% in Arm A experienced severe flaking/scaling/dryness extending beyond the application site. Non-severe, potentially treatment-related events included erythema extending beyond the application
Author(s): Xu, Ann; Patel, Viraat; Sutton, Leigh; Orengo, Ida | Abstract: The diagnosis of infiltrative basal cell carcinoma (BCC) can be delayed owing to its often subtle clinical findings. A 90-year-old woman presented with an asymptomatic annular pink plaque on her left shin that was clinically diagnosed as tinea corporis. After years of not responding to topical anti-fungal therapy, biopsies confirmed a diagnosis of infiltrative BCC. We discuss the differential diagnosis of the case, the difficulties in identifying infiltrative BCC, and the pathologic features of infiltrative BCC.
Mandel VD, Arginelli F, Pellacani G, Greco M. Combined carbon dioxide laser with photodynamic therapy for the treatment of nodular and infiltrative basal cell carcinoma. G Ital Dermatol Venereol 2017;152:672-4. DOI: 10.23736/S0392-0488.16.05395-5 ...
dermatology atlas, morpheaform basal cell carcinoma, morpheaform basal cell carcinoma histology, basal cell carcinoma, basal cell carcinoma histology, dermatology histology, image, atlas dermatology, skin cancer histology, morpheaform, basal cell carcinoma on leg, basal cell carcinoma, basal cell carcinoma histology, basal cell carcinoma morpheaform, skin carcinoma histology, dermatologist atlas, basal cell carcinoma histopathology, photo of basal cell carcinoma, alopecia histology pictures, high power squamous cell carcinoma histopathology skin, ...
For most patients with basal cell carcinoma, these lesions appear on areas of the skin that are frequently exposed to the sun, such as the hands, arms, neck or face. However, basal cell carcinoma can also develop in less obvious places, such as the abdomen or legs.. Because basal cell carcinoma typically results in favorable outcomes when diagnosed and treated in its early stages, it is critical that individuals showing any basal cell carcinoma symptoms promptly schedule an appointment with a physician who can diagnose their condition and recommend an effective course of treatment. For individuals in Clearwater, FL, this level of expertise is available at Moffitt Cancer Center in nearby Tampa. The oncologists, surgeons and other professionals in our Cutaneous Oncology Program have unparalleled experience in diagnosing and treating basal cell carcinomas, and we develop individualized treatment plans to give each patient the best chance at a favorable outcome and a positive quality of life.. If ...
Basal and squamous cell skin cancer are types of skin cancer that are found on the outer layer of the skin. Learn more about basal and squamous cell skin cancer here.
There are various forms of basal cell carcinoma.. Nodular basal cell carcinomas present as elevated lumps in the skin with a shiny surface, which often develop a small sore at the centre. Other, more superficial basal cell carcinomas appear as thin, brown or red patches of skin. They can easily be mistaken for dry skin patches, actinic keratosis, eczema or psoriasis, but they do not respond to moisturising creams or topical steroids. Patients typically notice that they have a sore that wont heal.. ...
There are various forms of basal cell carcinoma.. Nodular basal cell carcinomas present as elevated lumps in the skin with a shiny surface, which often develop a small sore at the centre. Other, more superficial basal cell carcinomas appear as thin, brown or red patches of skin. They can easily be mistaken for dry skin patches, actinic keratosis, eczema or psoriasis, but they do not respond to moisturising creams or topical steroids. Patients typically notice that they have a sore that wont heal.. ...
Frequent localization of the disease are exposed skin - face and scalp area of the head. Only in 20% of cases the tumor appears in closed clothing areas (trunk, limbs). Basal cell carcinoma of skin, usually occurs in older people, but in recent years the disease is diagnosed in younger people. Experts explain this growing popularity of travel to tropical countries and the Vogue for tanning. What is basal cell carcinoma Basal cell skin cancer is common among Europeans kind of a malignant tumor. Basal cell carcinoma occurs in the cells of the skin layer, which is responsible for the regeneration of the epithelium or at the base of hair follicles. Despite the fact that the disease is considered as malignant type of tumor, it practically never leads to the development of distant metastases. The tumor tend to increase invasive manner, it spreads into the surrounding tissues and destroys them. Starts as skin cancer? The initial stage of basal cell carcinoma characterized by the appearance on the skin small
ePlasty is an exclusively online journal of plastic surgery. The aim of the Journal is to facilitate a rapid publication process and provide wider accessibility to material for readers. ePlasty incorporates all aspects of acute and reconstructive plastic surgery, including cosmetic and breast surgery, maxillofacial and craniofacial surgery, Hand and peripheral nerve, microsurgery and face and hand transplants, disorders of skin, the treatment of burns, Management of benign and malignant tumors, Basic science and Regenerative medicine and stem cells. It also comprises a case-based learning library that is accessible to plastic and reconstructive surgeons, residents, and medical students around the world, free of charge that is uniquely tailored to board preparation and resident education.
ePlasty is an exclusively online journal of plastic surgery. The aim of the Journal is to facilitate a rapid publication process and provide wider accessibility to material for readers. ePlasty incorporates all aspects of acute and reconstructive plastic surgery, including cosmetic and breast surgery, maxillofacial and craniofacial surgery, Hand and peripheral nerve, microsurgery and face and hand transplants, disorders of skin, the treatment of burns, Management of benign and malignant tumors, Basic science and Regenerative medicine and stem cells. It also comprises a case-based learning library that is accessible to plastic and reconstructive surgeons, residents, and medical students around the world, free of charge that is uniquely tailored to board preparation and resident education.
The Incidence of Non-Melanoma Skin Cancer in the United States. Skin cancer is the most common form of cancer in the United States. Did you know it is currently estimated that one in five Americans will develop skin cancer during their lifetime? Nearly 10,000 U.S. citizens are diagnosed every single day.. In 2012 alone, it was estimated that over 5 million cases of non-melanoma skin cancer, including both basal cell carcinoma and squamous cell carcinoma, were treated in at least 3 million Americans.. Skin cancer is on the rise as well. Between 1976 and 2010, incidences of basal cell carcinoma increased by 145%. Squamous cell carcinoma increased by over 260% in the same time period.. The Latest Treatment Option for Non-Melanoma Skin Cancers. To combat this large increase in the incidence of non-melanoma skin cancers, Sensus Healthcare developed the SRT-100™, a system that uses precise, calibrated doses of Superficial Radiation Therapy to destroy cancer cell DNA, effectively disrupting their ...
Basal cell carcinoma (BCC) is the most common cancer among skin cancers. The incidence of cutaneous malignant melanoma (CMM) and non-melanoma skin cancer (NMSC) has increased more than 600% worldwide since the 1940s. Carcinogenesis is a multi-step process involving multiple genetic alterations. The connection between cell cycle proliferation and cancer resulting in deregulated cellular proliferation leads to cancer. Cancer has been associated with disturbances in cell cycle regulation. Recent studies have shown that p16, CDK6 and CCND1 mRNA genes and protein expression are involved in the tumorgenesis of skin cancer. These genes play a role in cell cycle proliferation. In this study, we assessed the expression of a cyclin, a cyclin dependent kinase, and a cyclin kinase inhibitor in skin BCC tissue. Reverse Transcription in situ polymerase chain reaction (RT in situ PCR) and immunohistochemistry (IHC) were used to detect the expression of p16, CDK6 and CCND1 mRNA genes through them of protein ...
Basal cell carcinomas in elderly patients treated by cryotherapy Anca Chiriac,1 Doina Mihaila,2 Liliana Foia,3, Caius Solovan4 1Department of Dermatology, Nicolina Medical Center, 2Department of Pathology, St Maria Children's Hospital, 3Surgical Department, Grigore T Popa University of Medicine and Pharmacy, Iaşi, Romania; 4Victor Babe University of Medicine, Timişoara, Romania Abstract: Basal cell carcinoma is a malignant skin tumor with high incidence in our country, especially in rural areas, on sun-exposed skin (particularly on the face) in elderly patients. We present three cases of basal cell carcinoma with good results with cryotherapy. This report aims to outline and to prove that in some difficult situations, a simple, inexpensive, easy-to-perform procedure with no contraindications and with minimal side effects (erythema, mild pain) can be applied and resolve such cases. Keywords: basal cell carcinoma, cryotherapy
Basal cell skin cancer: Find the most comprehensive real-world symptom and treatment data on basal cell skin cancer at PatientsLikeMe. 235 patients with basal cell skin cancer experience fatigue, depressed mood, anxious mood, pain, and insomnia and use Mohs Micrographic Surgery (MMS), Gabapentin, Tramadol, Hydrocodone-Acetaminophen, and Hydroxyzine to treat their basal cell skin cancer and its symptoms.
Symptoms of Basal cell carcinoma including 12 medical symptoms and signs of Basal cell carcinoma, alternative diagnoses, misdiagnosis, and correct diagnosis for Basal cell carcinoma signs or Basal cell carcinoma symptoms.
Press Release issued Feb 10, 2015: Non-melanoma skin cancers develop in the outermost layer of skin, known as epidermis. It is caused by increased exposure of genetic mutations, UV rays and ozone layer depletion. Non-melanoma skin cancer is mainly classified into two types. They are basal cell carcinoma and squamous cell carcinoma. Basal cell carcinoma is one of the most common types of skin cancers. It accounts about 70% of all skin cancers. Basal cell carcinoma starts underneath of the epidermis. Basal cell carcinoma usually appears as a red or pink lump. It usually develops on ears, face and neck. Squamous cell carcinoma accounts 20% of skin cancer. It starts on the upper side of epidermis. Squamous cell carcinoma appears as a red lump which develops into tumors. This type of cancer usually appears on that parts of the body which are directly exposed to the sun. It includes hands, face, ears, lips and legs.
Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several cancers. Vismodegib is approved for the treatment of locally advanced and metastatic basal cell carcinoma (BCC). Most BCC patients experience significant clinical benefit on vismodegib, but some develop resistance. Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2. SMO mutations either directly impaired drug binding or activated SMO to varying levels. Furthermore, we found evidence for intra-tumor heterogeneity, suggesting that a combination of therapies targeting components at multiple levels of the Hh pathway is required to overcome resistance. ...
Nonmelanoma skin cancer is the most common cancer worldwide (melanoma skin cancer is much more rare - though increasing at a very fast rate). Recent studies suggest that nonmelanoma skin cancer is becoming much more common among women, and the increase is especially dramatic among young women. According to the Canadian Dermatology Association, a person born in 1930 faces a 1-in-500 chance of developing nonmelanoma skin cancer in his or her lifetime, whereas a person born after 1994 faces a 1-in-7 chance.. This increase has occurred because more people are overexposed to ultraviolet (UV) radiation. People are living longer. People of this generation have often been exposed to the sun more than their parents because they tend to have more opportunity for leisure activities in the sun. The thinning of the earths ozone layer (caused by pollution and chemicals) also contributes to the increased occurrence of nonmelanoma skin cancer.. The two most common types of nonmelanoma skin cancer are basal ...
Skin cancer as a single entity is the most common malignancy in North America, accounting for half of all human cancers. It comprises two types: melanoma and nonmelanoma skin cancers. Of the nonmelanomas, basal cell carcinoma (BCC) constitutes about 80% of the cancers diagnosed every year. BCC usually occurs in sun-exposed areas such as the face and extremities. Occurrence in the nipple areolar complex is very rare. We present a case of a Caucasian woman who presented with what was initially thought to be invasive carcinoma of the breast involving the nipple areolar complex (NAC); however, the diagnosis was revealed to be a basal cell carcinoma after histopathological examination. The tumor was treated with modified radical mastectomy, with negative margins. The importance of this case lies in the rare site of presentation of basal cell carcinoma and the importance of early detection.
... Approximately more than one million new basal cell carcinoma diagnosis are currently recognized each year in the United States, and the incidence is rising. Basal cell carcinoma usually appears on skin that has been exposed to the sun such as the face, ears, chest, back, legs, and scalp. The appearance of BCC is that of a pink, slightly elevated growth, a reddish patch of skin, a raised, shiny, skin-colored bump with tiny blood vessels, or a sore that continuously heals and then re-opens. BCC grows slowly and usually does not metastasize. It occurs more often in fair-skinned individuals. In the past, BCC usually appeared in older individuals, but has been appearing more in younger people because of sun exposure at an earlier age.. Moles and Melanoma. Squamous Cell Carcinoma. Kaposis Sarcoma. Lymphoma. Skin Cancer Treatments ...
The human homologue of the Drosophila segment polarity gene patched (PTCH) has recently been identified as the tumor suppressor gene responsible for the nevoid basal cell carcinoma (BCC) syndrome (H. Hahn et al., Cell, 85: 841-851, 1996; R. L. Johnson et al., Science (Washington DC), 272: 1668-1671, 1996). In addition to multiple BCCs, patients with nevoid BCC syndrome have a predisposition for the development of primitive neuroectodermal tumors (PNETs) of the central nervous system. We have analyzed 9 sporadic BCCs and 37 PNETs for mutation and expression of the PTCH gene. PTCH mutations were found in 3 BCCs (33.3%) and in 5 PNETs (14%), including 1 of 5 cerebral PNETs, 2 of 15 medulloblastomas, and 2 of 17 desmoplastic medulloblastomas. The sequence changes in six of these tumors (four PNETs, two BCCs) were mutations predicted to result in truncated proteins. Missense mutations were detected in one PNET and one BCC each. In addition, novel sequence polymorphisms were found in exon 2, intron 5, ...
This page provides relevant content and local businesses that can help with your search for information on Basal Cell Carcinoma Treatment. You will find informative articles about Basal Cell Carcinoma Treatment, including Cancers And Benign Lesion Of The Eyelids Causes And Treatments. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in South Portland, ME that can help answer your questions about Basal Cell Carcinoma Treatment.
This page provides relevant content and local businesses that can help with your search for information on Basal Cell Carcinoma Treatment. You will find informative articles about Basal Cell Carcinoma Treatment, including Cancers And Benign Lesion Of The Eyelids Causes And Treatments. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Guilford, CT that can help answer your questions about Basal Cell Carcinoma Treatment.
The stage of a basal or squamous cell skin cancer is a description of how widespread the cancer is. This the most important factor in determining treatment and probable outcome. Learn more here.
Title:Non-Melanoma Skin Cancer - Overview. VOLUME: 12 ISSUE: 3. Author(s):Kurian Joseph. Affiliation:Department of Oncology, Staff Radiation Oncologist, Cross Cancer Institute, Associate Professor, 11560 University of Alberta, Edmonton, Alberta T6R 1Z2. Keywords:Non-melanoma skin cancer, MMS, PDT, BCC, SCC.. Abstract:Non-Melanoma Skin Cancer (NMSC) is the most common form of skin cancer. Common risk factors linked to the occurrence of NMSC are occupational exposure to chemicals, ultraviolet light exposure, immunosuppresion, human papillomavirus infection, artificial tanning, premalignant skin lesions and inherited skin conditions. The various clinical manifestations of NMSC depend on location and subtype. Management of NMSC includes pathology confirmation, staging and treatment. Retinoid and nicotinamide have been shown to be effective for the prevention of NMSC, primary treatments available for the treatment of NMSC are wide local excision, Mohs micrographic surgery (MMS), radiotherapy (RT), ...
MODEL RELEASED. Large seborrhoeic wart (on nose) & a smaller basal cell carcinoma (on lower eyelid) on a mans face. Basal cell carcinoma (also called rodent ulcer) is the most common type of skin cancer, most frequently occurring on the head & face. Basal cell skin cancers are related to long term, chronic exposure to the suns ultraviolet radiation; agricultural and construction workers are most at risk. The cancer may be successfully treated if diagnosed and removed before secondary complications occur. Seborrhoeic warts are produced by excessive secretion of sebum by the sebaceous glands; the nose is a typical site. - Stock Image M131/0138
Melanoma is the leading cause of death among skin cancer types, so its understandable that it has become a major focus of the healthcare community. Non-melanoma skin cancers account for over 90 percent of all skin cancers in the United States, and while they are usually more easily managed, they can pose a serious problem if left unchecked.. The distinction between melanoma and non-melanoma skin cancer is important to discuss, as prognosis and management are different for each. Melanoma typically requires targeted therapy or immunotherapy, whereas surgical resection (a procedure to remove part of an organ or gland) and chemotherapy are more common approaches for non-melanoma skin cancer. Newer, targeted therapy approaches have also emerged for non-melanoma skin cancers.. What follows is an overview of the two most common types of non-melanoma skin cancer: basal cell carcinoma and squamous cell carcinoma.. Basal Cell Carcinoma. Basal cell carcinoma originates from cells called keratinocytes. ...
These are several variations of basal cell carcinomas. Pigmented basal cell carcinomas are very dark, and more common in Asians, Hispanics and blacks.
This is the official website of Razi Journal of Medical Sciences published by Tehran University of Medical Sciences.The Razi Journal of Medical Sciences (RJMS) is the scientific medical journal of Iran, which has been published from 1993 onward in Persian with abstract of English language (former Journal of Iran University of Medical Sciences). Although it had been published quarterly in the past, RJMS has been published monthly (12 issues per year) from the year 2009. The Razi Journal of Medical Sciences, a scientific and research peer reviewed journal, seeks to publish original papers, selected review articles and case reports. RJMS also seeks to provide its readers with the highest quality materials published through a process of careful double-blind peer reviews and editorial comments. RJMS is an official publication of the Tehran University of Medical Sciences.
Basal cell carcinoma is the commonest, and the least life-threatening, form of skin cancer.. The reported incidence of basal cell carcinomas has drastically increased over recent decades and continues to rise. They usually appear as a red lump or scaly area. They grow slowly, rarely spread to other parts of the body and can usually be removed surgically.. The non-melanoma skin cancers; basal and squamous cell carcinoma, are not usually fatal, but their surgical treatment can result in scars.. ...
So far all of the sites have come back as Basal Cell Carcinoma. Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting approximately one million Americans each year. In fact, it is the most common of all cancers. These cancers arise in the basal cells, which line the deepest layer of the epidermis (top skin layer). Basal cell carcinomas are easily treated in their early stages. The larger the tumor has grown, however, the more extensive the treatment needed. Although this skin cancer seldom spreads, or metastasizes, to vital organs, it can damage surrounding tissue, sometimes causing considerable destruction and disfigurement - and some basal cell carcinomas are more aggressive than others ...
The FDA approved Odomzo (sonidegib) to treat patients with locally advanced basal cell carcinoma that has recurred following surgery or radiation therapy, or who are not candidates for surgery or radiation therapy. Skin cancer is the most common cancer and basal cell carcinoma accounts for approximately 80 percent of non-melanoma skin cancers. Basal cell carcinoma starts in the top layer of the skin (called the epidermis) and usually develops in areas that have been regularly exposed to the sun and other forms of ultraviolet radiation. - Year:2015
US Pharm. 2019;44(8):29-35.. ABSTRACT: In the United States, basal cell carcinoma (BCC) is diagnosed in approximately 2 million people each year. The most common cause of BCC is a mutation in the sonic hedgehog signaling pathway that is caused by ultraviolet damage and leads to uncontrolled cell growth. The hedgehog pathway inhibitors are a novel drug class initially created to treat advanced or metastatic BCC. Unique adverse effects of this class include muscle spasms, alopecia, increased creatine kinase levels, and anorexia. Patients can develop resistance to hedgehog pathway inhibitors. Clinical trials are investigating the use of hedgehog pathway inhibitors in a variety of malignancies and treatment algorithms.. Although it seldom makes headlines, basal cell carcinoma (BCC) is the most common cancer in the United States.1,2 Approximately 2 million cases of this skin cancer are reported in the U.S. each year, exceeding the incidence of all other cancers combined. Despite this large number, ...
TY - JOUR. T1 - Margin involvement and clinical pattern of basal cell carcinoma with mixed histology. AU - Betti, R.. AU - Radaelli, G.. AU - Crosti, C.. AU - Ghiozzi, S.. AU - Moneghini, L.. AU - Menni, S.. PY - 2012/4. Y1 - 2012/4. N2 - Background Mixed basal cell carcinoma (BCC) has not been sufficiently and specifically studied. Objective The aim of this study was to estimate in adults the prevalence of mixed cases observed among primary BCCs and to compare clinical and anatomical features of mixed vs. single BCCs, with focus on the incomplete excision. Patients and methods A total of 3636 histologically confirmed primary BCCs were examined. Data on gender, age, histological subtype, anatomical location and margin involvement were collected. Mixed type was defined as a combination of two or more single subtypes. Results Prevalence of single and mixed BCCs was 82.2% and 17.8% respectively. Prevalence of BCCs on the upper limbs was higher in mixed than single cases (8.8% vs. 4.0%; P ,0.001) ...
Histological cure of the lesion was confirmed in 89.5% of the patients. The peak of skin inflammation occurred during the first eight weeks of treatment in 68% of the patients, and 95% developed ulceration in this period. Reactional conjunctivitis affected 79% of the patients, keratitis 68%, deterioration of visual acuity 42%, and ectropion 32%. The distance from the lesion to the eyelid margin was significantly smaller in patients presenting ectropion during treatment (p=0.045).. ...
Basal cell carcinoma is the most common skin malignancy and is found in skin exposed to the sun. It is rarely seen bilaterally in ears, ankles or breasts. There has been no literature about bilateral basal cell carcinoma of lower eyelids symmetricall
Basal cell carcinoma is the most common type of skin cancer in Caucasians worldwide. Although rarely metastatic, it can be locally destructive causing disfigurement and pain. Current therapies include surgical removal, local destruction, radiotherapy and others.. Advances in understanding the molecular basis behind BCCs indicate that mutations in the hedgehog signaling pathway can lead to the development of many sporadically occurring basal cell carcinomas (BCCs). An oral drug that targets the hedgehog signaling pathway has been shown to be effective in treating patients with metastatic and inoperable BCCs. There is evidence that itraconazole, a commonly prescribed antifungal medication may also affect this pathway. It is not known whether itraconazole ointment applied topically can affect the growth of BCCs. ...
Radiation-Related Risk of Basal Cell Carcinoma: A Report From the Childhood Cancer Survivor Study. Watt, Tanya C.; Inskip, Peter D.; Stratton, Kayla; Smith, Susan A.; Kry, Stephen F.; Sigurdson, Alice J.; Stovall, Marilyn; Leisenring, Wendy; Robison, Leslie L.; Mertens, Ann C. // JNCI: Journal of the National Cancer Institute;Aug2012, Vol. 104 Issue 16, p1240 Background Basal cell carcinoma (BCC) is the most common malignancy in the United States. Ionizing radiation is an established risk factor in certain populations, including cancer survivors. We quantified the association between ionizing radiation dose and the risk of BCC in childhood cancer... ...
Basal cell carcinoma biopsy possible if ingrown hairs - Basal cell carcinoma biopsy possible if ingrown hairs? I agree. Bcc is possible on any part of the skin. However, ingrown hairs are not a risk factor for bcc.
This roughly 430% increase could be explained by the number of diagnoses made in the city, intense solar radiation and the habit of sun exposure.. The highest incidence was among women, representing 51.1% of cases, although the difference cannot be considered significant (p>0.05); in the literature the incidence in both sexes is virtually the same.13-15. As to age, the highest incidence was in the 40-60 year group, which agrees with other studies.1,13-15 The primary site of most of the basal cell carcinomas (77.75%) was in exposed areas, like in other statistical surveys.2,6,15,16. The incidence of basal cell carcinomas on the ear pinna was higher in men (63.64%) than in women (36.4%), probably due to an important epidemiological factor: the hair length covering the female pinna, with the consequent natural protection against ultraviolet radiation. This difference can be considered statistically significant (p,0.05).. Furthermore, a higher incidence was found on the nasal pyramid of women ...
Basal cell carcinoma is a very common, treatable form of skin cancer. There are multiple treatment options available for basal cell carcinoma, depending on the specific diagnosis. The cancer team at Mercy can help develop a treatment plan specific to your health needs, helping you get back on track.
These nine basal cell carcinoma pictures can help you identify this most common type of skin cancer. Learn more about basal cell carcinoma.
Healing a large basal cell carcinoma with essential oils Video Summary: The gentleman in the video below was diagnosed with a large basal cell carcinoma on…
A 64-year-old man, phototype V in Fitzpatrick scale, presented with a 5-year history of a slowly extending ulcer of the scalp. He had a past medical history of diabetes mellitus and ionizing radiation for tinea capitis in childhood. The physical examination revealed an oval-shaped ulcer measuring 7 cm in width x 5 cm in length, with a raised pigmented border; the center was alopecic, scattered by hemorrhagic, necrotic and crusted erosions. He had neither cervical enlarged lymph nodes nor visceromegaly. The histopathological study of the biopsy specimen confirmed the diagnosis of basal cell carcinoma. A combined cranial, thoracic, abdominal and pelvic computed tomography scan was normal. Particularly, there was no adjacent bone involvement. A surgical excision with reconstruction was undergone. No signs of dissemination or local recurrence have been detected after follow up of two years. We still observe on the 21st century cases of giant basal cell carcinoma. In our case multiple factors could explain
PRIMARY OBJECTIVES:. I. To determine whether administration of arsenic trioxide (ATO) to patients with basal cell carcinoma is associated with a reduction in Gli messenger ribonucleic acid (mRNA) and protein levels in tumor biopsy samples, when compared to baseline levels.. SECONDARY OBJECTIVES:. I. To determine whether there is evidence of tumor size reduction of ATO against basal cell carcinoma in humans.. OUTLINE:. Patients receive arsenic trioxide intravenously (IV) over 2 hours on days 1-5. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. ...
Complications of Basal Cell Carcinoma, Susceptibility to, 1 including hidden complications, secondary medical conditions, symptoms, or other types of Basal Cell Carcinoma, Susceptibility to, 1 complication.
These are some of the images that we found within the public domain for your "Basal Cell Carcinoma" keyword. These images will give you an idea of the kind of image(s) to place in your articles and wesbites. You can always use one of these images but please respect the copyright of the owner, We have provided the original source link for you to also credit the image(s) owner as we have done here.. ...
Basal cell carcinoma staging: Usage? Although a common condition, Basal Cell Carcinoma is highly treatable and most patients have a good prognosis.
The FDA has approved the use of Erivedge (vismodegib) to treat locally advanced, metastatic basal cell carcinoma in adult patients who are not candidates for surgery.. The new drug, the first for this indication, is a pill taken once daily, and works by blocking the Hedgehog pathway, which is active in most basal cell cancers and in only a few normal tissues (such as hair follicles). "Our understanding of molecular pathways involved in cancer, such as the Hedgehog pathway, has enabled the development of targeted drugs for specific diseases," Richard Pazdur, MD, Director of the Office of Hematology and Oncology Products in the FDAs Center for Drug Evaluation and Research, said in a statement. "This approach is becoming more common. This is important for patients who will have access to more effective therapies with potentially fewer side effects.". Erivedge, marketed by Genentech, won approval through the agencys priority review program, which expedites a drugs review process for therapies ...
OMNS Nov 9 2007) The most common form of skin cancer, basal cell carcinoma, often responds to a remarkably simple, safe, at-home treatment: vitamin C. Physicians and patients report that vitamin C, applied directly to basal cell skin cancers, causes them to scab over and drop off. [1] Successful use involves a highly-concentrated vitamin C solution, directly applied to the blemish two or three times a day. Vitamin C is selectively toxic to cancer cells, but does not harm healthy skin cells. This is also the basis for high-dose intravenous vitamin therapy for cancer. [2] Even higher concentrations of vitamin C can be obtained by direct application. The use of topical vitamin C to kill basal cell carcinoma has been known at least since 1971. Frederick R. Klenner, MD, wrote: We have removed several small basal cell epithelioma with a 30 percent ointment of vitamin C. [3 ...
McLaren, K. & Benton, E. (1997). Prevailing papillomavirus types in non-melanoma carcinomas of the skin in renal allograft recipients. A. & Proby, C. (2002). Human papillomaviruses and non-melanoma skin cancer. ; Schmook, T. & Meyer, T. (2004). Human papillomaviruses in transplant-associated skin cancers. ; Pukkala, E. & Karvonen, J. (1999). Basal cell skin carcinoma and other nonmelanoma skin cancers in Finland from 1956 through 1995. S. (1999). The mysteries of geographic variability in nonmelanoma skin cancer incidence. 4. Comparison of expression of CD44v6 (a), E48 (b) and U36 (c) in small frozen sections of BCCs, magnification 200x. 3 Markers p53 and Ki-67 in BCCs and BCC-free tumor margin tissue Molecular alterations can be found during carcinogenesis and tumor growth. As illustrated schematically in Figure 1 (cf. 1), the inactivation of tumor suppressor gene p53 is an important step towards carcinogenesis. During inactivation and mutation of p53 mutated p53 protein is formed. Mutated and ...
Skin cancer has been on the rise at an astonishing rate in the United States of America over the past 5 decades.. Specifically, these statistics relate to nonmelanoma skin cancers such as Basal Cell Carcinoma and Squamous Cell Carcinoma among other less common skin cancers. Melanoma skin cancers are not a part of these statistics as they are a reportable condition. For all skin cancers that dont get reported, estimates have been made based on billing records in most studies.. Because it is more difficult to estimate the total number of US nonmelanoma skin cancers, studies are done less frequently. Weve compiled the last four major studies based on a scientific journal search on pubmed.gov.. The first publication evaluated skin cancer rates in 1978.. "Currently between 400,000 and 500,000 individuals develop new basal cell or squamous cell carcinomas of the skin each year in the United States." (1978). - Scotto, J., T. R. Fears, and J. F. Fraumeni. 1983. Incidence of non-melanoma skin cancer in ...
What is the difference between basal cell carcinoma and squamous cell carcinoma? Sensus Healthcare provides an explanation and a non-surgical treatment option.
TY - JOUR. T1 - Pre-diagnostic plasma 25-hydroxyvitamin D levels and risk of non-melanoma skin cancer in women. AU - Liang, Geyu. AU - Nan, Hongmei. AU - Qureshi, Abrar A.. AU - Han, Jiali. PY - 2012/4/6. Y1 - 2012/4/6. N2 - Background: Recent reports have shown that vitamin D status was inversely associated with the risk of various cancers. However, few studies examined the association between vitamin D levels and risk of skin cancer. Methods: We prospectively evaluated the association between baseline plasma 25(OH)D levels and the risk of incident squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) among 4,641 women from the Nurses Health Study (NHS) and the NHS II with 510 incident BCC cases and 75 incident SCC cases. We used multivariate logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Plasma 25(OH)D levels were positively associated with risk of BCC after adjusting for age at blood draw, season of blood draw, lab batch, hair ...
For patients with superficial basal cell carcinoma (sBCC), treatment with imiquimod or photodynamic therapy (PDT) results in similar long-term tumor-free survival.
Risk factors for non-melanoma skin cancer include sun and ultraviolet radiation and having a fair complexion. Learn about non-melanoma skin cancer risk.
Risk factors for non-melanoma skin cancer include sun and ultraviolet radiation and having a fair complexion. Learn about non-melanoma skin cancer risk.
Aggressive basal cell skin cancers have higher levels of both EZH2 and Ki67, suggesting these proteins have potential to serve as biomarkers for when basal cell carcinoma has become dangerous.
Basal cell carcinoma (BCC) is a non-melanoma skin cancer caused by mutations in the DNA of skin cells, which then spread to adjacent cells. BCC occurs in the deepest (basal) layer of the skins outer layer, the epidermis. BCC is the most common form of skin cancer in the country. It often appears as a flat lesion with a waxy, yet scar-like appearance and usually forms in areas frequently exposed to the sun, such as the nose, neck, ears, and scalp ...
... Learn about non-melanoma skin cancers and find a treatment clinic in Clifton, NJ.
What is Non-Melanoma Skin Cancer? Get the facts about Non-Melanoma Skin Cancer symptoms, testing, treatment and care options from trusted sources.
Evidence-based recommendations on vismodegib (Erivedge) for treating basal cell carcinoma (BCC; non-melanoma skin cancer; rodent ulcers) in adults
Read about types of skin cancer (Basal Cell Carcinoma/BCC, Squamous Cell Carcinoma, Malignant Melanoma), what they look like, their early signs (ABCD Rule) and advice on examining you body.
Basal cell carcinoma is the most common skin cancer and the least dangerous-but its far from a trivial matter, reports the May issue of the Harvard Womens…
It is well known that excessive sun exposure can promote the development of many skin cancers. The 3 main types of skin cancer are melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Melanoma is the most deadly skin cancer because it spreads (metastasizes) more readily than the other forms of skin cancer. Basal cell carcinoma is the most common form of skin cancer, and it typically does not spread. Squamous cell carcinoma is the second most common form of skin cancer, and while it can spread, it does not do so as commonly as melanoma. The risk of getting basal cell carcinoma or squamous cell carcinoma is determined by a persons lifetime exposure to sun and the persons skin color, with pale skin being more prone to skin cancer.. Your awareness of the signs of skin cancer might allow you to find an early lesion on yourself or a loved one, before it is a significant health problem. Pre-cancerous skin changes include red, scaly lesions (especially on the face, ears, and backs ...
Skin cancer has been on the rise at an astonishing rate in the United States of America over the past 5 decades.. Specifically, these statistics relate to nonmelanoma skin cancers such as Basal Cell Carcinoma and Squamous Cell Carcinoma among other less common skin cancers. Melanoma skin cancers are not a part of these statistics as they are a reportable condition. For all skin cancers that dont get reported, estimates have been made based on billing records in most studies.. Because it is more difficult to estimate the total number of US nonmelanoma skin cancers, studies are done less frequently. Weve compiled the last four major studies based on a scientific journal search on pubmed.gov.. The first publication evaluated skin cancer rates in 1978.. "Currently between 400,000 and 500,000 individuals develop new basal cell or squamous cell carcinomas of the skin each year in the United States." (1978). - Scotto, J., T. R. Fears, and J. F. Fraumeni. 1983. Incidence of non-melanoma skin cancer in ...
We did a multicentre, parallel-group, pragmatic, non-inferiority, randomised controlled trial at 12 centres in the UK, in which patients were recruited between June 19, 2003, and Feb 22, 2007, with 3 year follow-up from June 26, 2006, to May 26, 2010. Participants of any age were eligible if they had histologically confirmed primary nodular or superficial basal-cell carcinoma at low-risk sites. We excluded patients with morphoeic or recurrent basal-cell carcinoma and those with Gorlin syndrome. Participants were randomly assigned (1:1) via computer-generated blocked randomisation, stratified by centre and tumour type, to receive either imiquimod 5% cream once daily for 6 weeks (superficial) or 12 weeks (nodular), or surgical excision with a 4 mm margin. The randomisation sequence was concealed from study investigators. Because of the nature of the interventions, masking of participants was not possible and masking of outcome assessors was only partly possible. The trial statistician was masked ...
Basal cell carcinoma (BCC) is a common skin cancer that arises from the basal layer of epidermis and its appendages. Treatment of BCC is indicated due to the locally invasive, aggressive, and destructive effects of BCC on skin and surrounding tissues
Basal cell carcinoma (BCC) is a common skin cancer that arises from the basal layer of epidermis and its appendages ().Treatment of BCC is indicated due to the locally invasive, aggressive, and destructive effects of this tumor on skin and surroundin
Healing Cancer Naturallys cancer glossary and scientific reference: skin cancer, basal cell carcinoma, squamous cell carcinoma, malignant melanoma, Kaposis sarcoma.
Learn about effective treatment options for Basal cell carcinoma (BCC), the most common skin cancer. When detected early, BCC can be treated and cured.
Basal cell carcinomas and tumors are the most common forms of skin cancer found in dogs. Most basal cell tumors in dogs are benign, though they can become malignant. When caught early, they can be treated without further complications, usually with surgery. Heres what you should know.
Transforming growth factor alpha (TGF-alpha) is a 50-amino acid peptide, previously demonstrated only in transformed cell lines and human tumors, which is structurally homologous to epidermal growth factor (EGF). TGF-alpha expression in keratinocytes from normal individuals, patients with psoriasis, and patients with malignant skin diseases was investigated using an mAb raised against synthetic human TGF-alpha. mAb A1.5 reacted with TGF-alpha, but not EGF, in a sensitive ELISA. Keratinocytes in eight nodular basal cell carcinomas, one morpheic basal cell carcinoma, and one squamous cell carcinoma demonstrated intense membranous immunoperoxidase staining with mAb A1.5. Of even greater interest was the observation that the overlying normal epidermis, as well as the epidermis from five normal skin specimens, were stained by the mAb. Keratinocytes in plaques from 18 psoriasis patients were more intensely stained than those from normal skin. Cultured normal keratinocytes demonstrated membranous ...
In this study, the increased risk was seen for lung cancer, colon cancer, and breast cancer, Dr. Alberg says. "For prostate cancer, the trend was in the direction of increased risk, but the association was weaker and not statistically significant," he says.. Dr. Alberg believes the increased risk may be due to a weakened ability to repair DNA damage to cells. "People who have suboptimal ability to repair DNA damage that the sun can cause are far more likely to get nonmelanoma skin cancer. We are hypothesizing that that might also be the link to why there is a greater increased cancer risk in general," he says.. For the study, Dr. Albergs team looked at the risk of developing cancer among 769 people with a history of nonmelanoma skin cancer. The researchers compared these people to 18,405 people with no history of skin cancer.. Over 16 years of follow-up, the researchers found that the incidence of cancers was 293.5 per 10,000 person-years among people with a history of skin cancer, compared to ...
Genital high-risk human papillomaviruses (HPVs) cause cervical cancer and are also found in a small proportion of nonmelanoma skin cancers (NMSCs). We used cancer registry linkages to follow the 856,000 serum donors included in the Southern Sweden Microbiology Biobank or the Janus Biobank in Norway, for incident skin cancers occurring up to 30 years after serum donation. Serum samples taken before diagnosis of squamous cell carcinoma (SCC) (N = 633), basal cell carcinoma (BCC) (N = 1990) or other NMSC (N = 153) and matched samples from control donors were tested for antibodies to the genital HPV types 16 and 18. Both HPV 16 and 18 were associated with increased risk for SCC [odds ratio (OR) 1.6, 95% confidence interval (CI) 1.1-2.6 and OR 1.7, 95% CI 1.1-2.5, respectively] and other NMSC (OR 2.3, 95% CI 1.0-5.2 and OR 3.5, 95% CI 1.4-8.7, respectively), but not for BCC. Tumor blocks from HPV16 or 18 seropositive cases were tested with real-time polymerase chain reaction for presence of HPV16 or 18 DNA.
The Role of Bcl-2, CD10 and CD34 Expression in Differentiation between Basal Cell Carcinoma and Trichoepithelioma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
MODEL RELEASED. Basal cell carcinoma (BCC) skin cancer on the scalp of a 75 year old man. BCC is the most common type of skin cancer, and is thought to be related to overexposure to sunlight. There is also a strong genetic factor, as the disease tends to run in families. It is not a particularly aggressive cancer, and rarely metastasises (spreads) to other sites in the body. It does continue to grow though, and its growth can affect surrounding tissues. Treatment with surgical removal effects a cure in the majority of cases, although chemotherapy is effective as well. - Stock Image M131/0641
Basal cell carcinoma usually occurs in fair-skinned individuals with sun-damaged skin.3 It is three to four times more common than squamous cell carcinoma (SCC) and its incidence varies dramatically across various regions of the world reflecting the ethnic mix, ambient ultraviolet (UV) light exposure, and sun behavior habits of the population.3 The highest rates of BCC occur in Australia where national studies have documented a rate of 884/100,000 person-years, with an even higher incidence rate in some regions.3,4 The lowest recorded rates of BCC are in parts of Africa, with rates of less than 1/100,000 person-years.3 Globally, the incidence of BCC is increasing and European studies indicate that rates of BCC in Europe have been increasing on average by 5.5% each year.3 This increase in incidence is particularly dramatic in older age groups, with the greatest increase occurring in people aged 60 years and older.5 Less than 1% of all BCCs occur in individuals less than 25 years of age and there ...
New York, NY (May 13, 2015) - Tawny Willoughbys jarring image is a harsh reminder that there is no such thing as a safe tan. Those who begin tanning before age 35 increase their risk of developing melanoma by almost 75 percent. In addition, those who have ever tanned indoors have a 67 percent increased risk of developing squamous cell carcinoma and a 29 percent increased risk of developing basal cell carcinoma.. Many people think that melanoma is the only skin cancer to fear. While melanoma is the most serious form of skin cancer, the nonmelanoma skin cancers (basal cell carcinoma and squamous cell carcinoma) that Tawny has been treated for should be taken seriously as well. People who have had nonmelanoma skin cancers are at an increased risk for developing others over the years. They can also be disfiguring and even, in some cases, deadly.. Its important that everyone adopts a year-round, complete sun protection regimen that includes seeking shade and covering up with clothing, including a ...
As we continue through Skin Cancer Awareness Month, Basal Cell Carcinoma is the most common of the skin cancers. It is diagnosed in millions every year.
Basal cell carcinoma is a slow-growing, invasive, but usually non-metastasizing neoplasm recapitulating normal basal cells of the epidermis or hair follicle
Introduction. Basal cell carcinoma (BCC) is the most common cancer in the white population. Patients are increasingly young, and the rise in incidence, together with the enormous associated health care costs,1 calls for new diagnostic techniques that are fast, reliable, and affordable.. Incisional biopsy (generally punch biopsy) is used to confirm a diagnosis of BCC. However, this technique only targets a limited fragment of the tumor and it may fail to correctly classify histologic subtypes. There have been reports of aggressive subtypes being classified as nonaggressive following incisional biopsy. This is more frequent in mixed or large BCCs, where there is a greater chance of missing the most aggressive part of the tumor.2-6 Incorrect classification of histologic subtype can result in inappropriate treatment, increased recurrence rates, and higher costs.2-6. High-frequency ultrasound (HFUS) imaging of the skin is gaining increasing recognition as a first-line diagnostic tool for the ...
Hugh Jackman: Deb said to get the mark on my nose checked. Boy, was she right! I had a basil cell carcinoma. In a post to his Instagram followers, Hugh Jackman reveals that he was treated for basal cell carcinoma (BCC), the most common type of cancer in the United States in both men and women.
Austin, Texas dermatologist and Mohs surgeon Dr. Adam Mamelak explains the different clinical and histologic subtypes of basal cell carcinoma skin cancer
This type of pores and skin most cancers will not be as commonly unfold as basal cell carcinoma, but it is fairly popular in addition. It has an effect on the cells while in the upper layers of the pores and skin. It may possibly manifest by itself in alternative ways. The achievable signs and symptoms consist of persistent scaly pink patch with irregular borders, elevated advancement that has a melancholy inside the centre Using the despair bleeding at times, an open sore which keeps bleeding and crusting in cycles, advancement which looks like a wart, but receives crusty and bleeds occasionally ...
Background: Semitranslucency, defined as a smooth, jelly-like area with varied, near-skin-tone color, can indicate a diagnosis of basal cell carcinoma (BCC) with high specificity. This study sought to analyze potential areas of semitranslucency with histogram-derived texture and color measures to discriminate BCC from non-semitranslucent areas in non-BCC skin lesions. Methods: For 210 dermoscopy images, the areas of semitranslucency in 42 BCCs and comparable areas of smoothness and color in 168 non-BCCs were selected manually. Six color measures and six texture measures were applied to the semitranslucent areas of the BCC and the comparable areas in the non-BCC images. Results: Receiver operating characteristic (ROC)curve analysis showed that the texture measures alone provided greater separation of BCC from non-BCC than the color measures alone. Statistical analysis showed that the four most important measures of semitranslucency are three histogram measures: contrast, smoothness, and entropy, and one
each month represents certain causes, May is skin cancer/melanoma awareness month. I believe living in or even visiting our sunny state warrants the need for education, so I would like to describe the warning signs for skin cancer. Heres my disclaimer: I am not a doctor, so the opinions expressed here should not replace one-on-one medical advice.. Melanoma is the fastest-growing, deadliest skin cancer a person may have, but it is not the most common. Other types of skin cancer include Basal Cell Carcinoma and Squamous Cell Carcinoma.. Basal Cell Carcinoma makes up about 75% of all diagnosed skin cancers. They are usually found on the nose, ears, or other places that receive frequent sun exposure. People at risk for Basal Cell Cancer are those who have fair complexions, have blue or green eyes, blonde or red hair. Also, people who are overexposed to x-rays or other forms of radiation may be susceptible to basal cell lesions.. The lesions of basal cell carcinoma may look like a scar on a spot of ...
Basal cell carcinoma (BCC), the most common type of skin cancer, is occasionally aggressive with deep invasion, destruction of adjacent structures, recurrence and, on very rare occasions, regional and distant metastases. Mutations that occur in BCC in hedgehog (Hh) pathway genes primarily involve the genes encoding patched homolog (PTCH) and smoothened homolog (SMO). Several animal models have demonstrated the functional relevance of genetic alterations in the Hh pathway during tumorigenesis. Recently, targeted therapy has become available both commercially and in the context of human clinical trials. Interestingly, Hh pathway inhibitors not only suppress BCC progression but also promote acquired immune responses. Since immune responses are crucial for long-term tumor control, new clinical trials, such as those involving a combination of Hh inhibitors with immune modifiers, are needed to supplement standard methods of tumor control. ...
Basal Cell Carcinoma: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Basal cell carcinoma (BCC) is the most common type of skin cancer. Fortunately it is also the least dangerous and almost always completely cured by treatment.
Basal Cell Carcinoma, Persistence of Fetal Fingerpads, Relative Macrocephaly in Childhood Symptom Checker: Possible causes include Gorlin Syndrome, Actinic Keratosis, Skin Cancer. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
... is the most common form of skin cancer. This skin cancer occurs most frequently on sun-exposed areas of the body.
Basal cell nevus syndrome (BCNS; MIM 109400) also known as Gorlin syndrome, is an autosomal dominant disease characterized by basal cell tumors, palmar and plantar pits, jaw cysts and skeletal anomalies. Radiological findings include calcification of the falx cerebri, bridged sella, bifid ribs, hemivertebrae, and flame-shaped lucencies of the phalanges, metacarpal, and carpal bones of the hands. These patients can also have medulloblastoma, ovarian calcification or fibroma and cardiac fibroma. Craniofacial findings may include coarse facies, macrocephaly, hypertelorism, frontal bossing and cleft palate. BCNS can be caused by mutations in the PTCH1, PTCH2 or SUFU genes. These genes code for protein patched homolog 1, protein patched homolog 2 and suppressor of fused homolog.. The basal cell nevus syndrome NGS panel consists of three genes: PTCH1, PTCH2 and SUFU.. Copy number variation (CNV) analysis of the Basal cell nevus syndrome genes is also offered as a panel. Additionally, CTGT offers a ...
Recent studies have demonstrated the ability of confocal. fluorescence mosaicing microscopy to rapidly detect basal cell carcinomas. BCCs directly in thick and fresh Mohs surgical excisions.. Mosaics of confocal images display large areas of tissue with high. resolution and magnification equivalent to 2, which is the standard. magnification when examining pathology. Comparison of mosaics to. Mohs frozen histopathology was shown to be excellent for all types of. BCCs. However, comparisons in the previous studies were visual and. qualitative. In this work, we report the results of a semiquantitative. preclinical study in which 45 confocal mosaics are blindly evaluated. for the presence or absence of BCC tumor. The evaluations are made. by two clinicians: a senior Mohs surgeon with prior expertise in interpreting. confocal images, and a novice Mohs fellow with limited experience.. The blinded evaluation is compared to the gold standard of. frozen histopathology. BCCs are detected with an overall ...
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Basaloid squamous cell carcinoma (Bas-SqCC) is an uncommon histological variant of lung cancer composed of cells exhibiting cytological and tissue architectural features of both squamous cell lung carcinoma and basal cell carcinoma. Lung cancer is a large and exceptionally heterogeneous family of malignancies. Over 50 different histological variants of lung cancer are explicitly recognized within the fourth (2004) revision of the World Health Organization Classification of Lung Tumours ("WHO-2004"). Many of these entities are quite rare, have only been recently described, and remain poorly understood. Basaloid forms of lung carcinoma were first described in the peer-reviewed medical literature by Dr. Elisabeth Brambilla and her colleagues in 1992. In the third revision of the World Health Organization lung tumor typing and classification scheme, published in 1999, basaloid variants of both squamous cell lung carcinoma (SqCC) and large cell lung carcinoma (LCLC) were recognized as distinct ...
Imiquimod is a patient-applied cream used to treat certain diseases of the skin, including skin cancers (basal cell carcinoma, Bowens disease,[1]superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis) as well as genital warts (condylomata acuminata). However, Imiquimod is generally secondary to surgery, because surgery has a better chance to effectively treat at least some forms of skin cancer.[2]. Imiquimod has been tested for treatment of molluscum contagiosum. Two large randomized controlled trials, however, found no evidence of effectiveness of imiquimod in treating children with molluscum contagiosum, and concerning adverse effects were also noted.[3]. Imiquiomd has also been tested for treatment of vulvar intraepithelial neoplasia, common warts that have proven difficult to treat,[4] and vaginal intraepithelial neoplasia.[5]. Outstanding cosmetic result has resulted from the treatment of both large superficial basal cell carcinoma and squamous ...
Cutaneous Squamous cell Carcinoma (CsCC) - Epidemiology Forecast To 2025" provides an overview of the epidemiology trends of Cutaneous Squamous cell Carcinoma (CsCC) in seven major markets (US, France, Germany, Italy, Spain, UK and Japan). It includes 10 years epidemiology historical and forecasted data of Cutaneous Squamous cell Carcinoma (CsCC) prevalent or incident cases segmented by age, sex and subpopulations. The Report also discusses the prevailing risk factors, disease burden with special emphasis on the unmet medical need associated with the Cutaneous Squamous cell Carcinoma (CsCC). The report is built using data and information sourced from proprietary databases, primary and secondary research and in-house Forecast model analysis by team of industry experts.. The report will help in developing business strategies by understanding the trends shaping and driving the global Cutaneous Squamous cell Carcinoma (CsCC) market. It helps in identifying prevalent patient populations as well as ...
Magnolol, a plant lignan isolated from the bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on chemically-induced skin cancer development. The objectives of this investigation are to study the anticarcinogenic effects of magnolol on UVB-induced skin tumor development in SKH-1 mice, a model relevant to humans, and determine the possible role of apoptosis and cell cycle arrest involved in the skin tumor development. UVB-induced skin carcinogenesis model in SKH-1 mice was used for determining the preventive effects of magnolol on skin cancer development. Western blottings and flow cytometric analysis were used to study the effects of magnolol on apoptosis and cell cycle. Magnolol pretreated groups (30, 60 μ g) before UVB treatments (30 mJ/cm2, 5 days/week) resulted in 27-55% reduction in tumor multiplicity as compared to control group in SKH-1 mice. Magnolol pretreatment increased the cleavage of caspase-8 and poly-(-ADP-ribose) polymerase (PARP), increased the
TY - JOUR. T1 - Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis. AU - Toutfaire, Marie. AU - Dumortier, Elise. AU - Fattaccioli, Antoine. AU - Van Steenbrugge, Martine. AU - Proby, Charlotte M.. AU - Debacq-Chainiaux, Florence. PY - 2018/5/1. Y1 - 2018/5/1. N2 - Cutaneous Squamous Cell Carcinoma (cSCC) is the second most common type of non-melanoma skin cancer in white-skinned populations. cSCC is associated with sun exposure and aging, which is concomitant with an accumulation of senescent cells in the skin. The involvement of senescent cells in carcinogenesis has been highlighted in several cancer types and an interaction between cSCC cells and senescent cells is proposed, but still little explored. Tumor-associated effects are mostly attributed to the senescence-associated secretory phenotype (SASP). Here, we compared two in vitro models of senescence, namely replicative senescence and ...
This paper describes a quantitative analysis of the cyst lining architecture in radicular cysts (of inflammatory aetiology) and odontogenic keratocysts (thought to be developmental or neoplastic) including its 2 counterparts: solitary and associated with the Basal Cell Naevus Syndrome (BCNS). Epithelial linings from 150 images (from 9 radicular cysts, 13 solitary keratocysts and 8 BCNS keratocysts) were segmented into theoretical cells using a semi-automated partition based on the intensity of the haematoxylin stain which defined exclusive areas relative to each detected nucleus. Various morphometrical parameters were extracted from these cells and epithelial layer membership was computed using a systematic clustering routine. Statistically significant differences were observed across the 3 cyst types both at the morphological and architectural levels of the lining. Case-wise discrimination between radicular cysts and keratocyst was highly accurate (with an error of just 3.3%). However, the

Basal cell carcinoma - wikidocBasal cell carcinoma - wikidoc

Skin Nodular Basal Cell Carcinoma, Skin Morphea-Type (Sclerosing) Basal Cell Carcinoma, Skin Clear Cell Basal Cell Carcinoma, ... basal-cell cancer,Skin Fibroepithelial Basal Cell Carcinoma, Skin Signet Ring Cell Basal Cell Carcinoma, Skin Sarcomatoid Basal ... Cell Carcinoma, Superficial Multifocal Basal Cell Carcinoma, Superficial Basal Cell Carcinoma, Skin Basosquamous Cell Carcinoma ... Synonyms and Keywords: Basal cell epithelioma, rodent ulcer, Ronald Reagan tumor, infiltrative basal cell carcinoma, ...
more infohttp://www.wikidoc.org/index.php/Basal_cell_carcinoma

Nevoid Basal Cell Carcinoma Syndrome | JAMA Dermatology | The JAMA NetworkNevoid Basal Cell Carcinoma Syndrome | JAMA Dermatology | The JAMA Network

A patient with the nevoid basal cell carcinoma syndrome had been treated with radiation therapy to the hands at 5 years of age ... Nevoid Basal Cell Carcinoma SyndromeMultiple Basal Cell Carcinomas of the Palms After Radiation Therapy. Arch Dermatol. 1980; ... Nevoid Basal Cell Carcinoma SyndromeMultiple Basal Cell Carcinomas of the Palms After Radiation Therapy. ... Multiple basal cell carcinomas of the palms and dorsa of the hands developed when the patient was 28 years of age. It is ...
more infohttps://jamanetwork.com/journals/jamadermatology/article-abstract/541430?redirect=true

Basal cell nevus syndrome | Roswell Park Comprehensive Cancer CenterBasal cell nevus syndrome | Roswell Park Comprehensive Cancer Center

People with this syndrome have a higher risk of basal cell carcinoma. Also called Gorlin syndrome and nevoid basal cell ...
more infohttps://www.roswellpark.org/glossary/basal-cell-nevus-syndrome

Is Seborrheic Keratosis Precancerous? | Ag3dermIs Seborrheic Keratosis Precancerous? | Ag3derm

The most widespread skin cancer is the basal cell carcinoma (BCC). Even though malignant, basal cell carcinoma grows very ... The next most prevalent skin cancer type is the basal cell carcinoma. In contrast, this has a speedy growth, undergoes ... In contrast with actinic keratosis which eventually results to squamous cell carcinoma, seborrheic keratosis is not a precursor ... The three types of skin cancer whose basis of nomenclature is based on the cells affected will be discussed in the next ...
more infohttp://www.ag3derm.com/is-seborrheic-keratosis-precancerous/

Mohs Micrographic Surgery: What is it? | About DermatologyMohs Micrographic Surgery: What is it? | About Dermatology

Its indicated for squamous cell carcinomas, basal cell carcinomas, and some other less common skin cancers. Mohs surgery is ... Cure rates are over 98% for squamous and basal cell carcinomas.. What can I expect the day of?. Read this handy infographic for ... In the example below, a recurrence of aggressive basal cell carcinoma on the nose (H area) has the highest score of possible ... I didnt realize that the cure rates are over 98% for squamous and basal cell carcinomas. Thanks for sharing! ...
more infohttp://aboutdermatology.com/procedures/mohs-micrographic-surgery-what-is-it

Basal cell skin cancer: MedlinePlus Medical EncyclopediaBasal cell skin cancer: MedlinePlus Medical Encyclopedia

Basal cell cancer is the most common form of cancer in the United States. Most skin cancers are basal cell cancer. ... Basal cell carcinoma; Rodent ulcer; Skin cancer - basal cell; Cancer - skin - basal cell; Nonmelanoma skin cancer; Basal cell ... With basal cancer, cells in this layer are the ones that become cancerous. Most basal cell cancers occur on skin that is ... Basal cell cancer is the most common form of cancer in the United States. Most skin cancers are basal cell cancer. ...
more infohttps://medlineplus.gov/ency/article/000824.htm

Basal Cell Carcinoma PathophysiologyBasal Cell Carcinoma Pathophysiology

Basal cell carcinomas are slow-growing cancers. They typically appear as elevated or flat lesions present on the sun-exposed ... Basal cell carcinoma localization. Basal cell cancers are limited in their growth and very rarely spread to other organs. ... A rare hereditary disorder called basal-cell nevus syndrome (BCNS) raises the risk of developing basal cell carcinoma. Also ... the susceptibility to basal cell cancers rises. Among those of European ancestry, the risk for basal cell carcinoma is ...
more infohttps://www.news-medical.net/health/Basal-Cell-Carcinoma-Pathophysiology.aspx

Basal Cell Carcinoma | HealthCentralBasal Cell Carcinoma | HealthCentral

It is a malignant epithelial cell tumor that begins as a papule (a small, circumscribed, solid elevation of the skin) and ... Definition Basal cell carcinoma is a type of skin cancer. ... type of basal cell carcinoma is nodular basal cell carcinoma, a ... Basal cell carcinoma (BCC) is the most common and least lethal form of all cancers. In the United States, basal cell cancer ... Basal cell carcinoma is a type of skin cancer. It is a malignant epithelial cell tumor that begins as a papule (a small, ...
more infohttps://www.healthcentral.com/encyclopedia/basal-cell-carcinoma

Skin Cancer | Basal Cell Carcinoma | MedlinePlusSkin Cancer | Basal Cell Carcinoma | MedlinePlus

Merkel Cell Carcinoma: Overview (American Academy of Dermatology) * Nevoid Basal Cell Carcinoma Syndrome (American Society of ... ClinicalTrials.gov: Carcinoma, Basal Cell (National Institutes of Health) * ClinicalTrials.gov: Carcinoma, Merkel Cell ( ... Childhood Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin Treatment ... Merkel Cell Carcinoma) (National Cancer Institute) * Treatment Options by Stage (Merkel Cell Carcinoma) (National Cancer ...
more infohttps://medlineplus.gov/skincancer.html

Basal Cell CarcinomaBasal Cell Carcinoma

Hundreds of thousands of people are diagnosed with basal cell carcinoma every year and while highly treatable, it can ravage ... Basal cell carcinoma can sometimes appear similar to skin conditions like eczema or psoriasis. If you have a new outbreak of ... As with most skin cancers, basal cell carcinoma tends to appear on body parts routinely exposed to sun such as the face, neck, ... Did you know that basal cell carcinoma is the most common kind of cancer in America? Hundreds of thousands of people are ...
more infohttps://www.qualityhealth.com/cancer-articles/basal-cell-carcinoma

Basal Cell Carcinoma Masked in RhinophymaBasal Cell Carcinoma Masked in Rhinophyma

I. Ahmad and A. R. Das Gupta, "Epidemiology of basal cell carcinoma and squamous cell carcinoma of the pinna," Journal of ... S. J. Miller, "Biology of basal cell carcinoma (part I)," Journal of the American Academy of Dermatology, vol. 24, no. 1, pp. 1 ... Basal Cell Carcinoma Masked in Rhinophyma. Daniele De Seta, Francesca Yoshie Russo, Elio De Seta, and Roberto Filipo ... C. S. M. Wong, R. C. Strange, and J. T. Lear, "Basal cell carcinoma," British Medical Journal, vol. 327, no. 7418, pp. 794-798 ...
more infohttps://www.hindawi.com/journals/criot/2013/201024/ref/

Basal Cell Carcinoma Diagnosis | MoffittBasal Cell Carcinoma Diagnosis | Moffitt

A biopsy is required to diagnose basal cell carcinoma. Click here to learn about the different types of biopsies your physician ... A basal cell carcinoma diagnosis can only be confirmed or ruled out through skin biopsies. In most cases, a patient will turn ... If a basal cell carcinoma diagnosis is made, our expert oncologists can recommend an individualized treatment plan based on a ... At Moffitt Cancer Center, we offer some of the most advanced diagnostic techniques currently available for basal cell carcinoma ...
more infohttps://moffitt.org/cancers/basal-cell-carcinoma/diagnosis/

Basal cell carcinoma: Self-careBasal cell carcinoma: Self-care

... Types and treatment Common types Basal cell Squamous cell Melanoma Merkel cell CTCL DFSP ... Once youve had basal cell carcinoma (BCC), you have a higher risk of developing another skin cancer, including melanoma, the ... After getting basal cell carcinoma, protecting your skin from the sun can reduce your risk of getting another skin cancer. ... "Basal cell carcinoma Contemporary approaches to diagnosis, treatment, and prevention." J Am Acad Dermatol 2019;80:321-39. ...
more infohttps://www.aad.org/diseases/skin-cancer/basal-cell-carcinoma-self-care

Treatment of Basal-cell Carcinoma | The BMJTreatment of Basal-cell Carcinoma | The BMJ

Treatment of Basal-cell Carcinoma. Br Med J 1949; 1 doi: https://doi.org/10.1136/bmj.1.4611.911-d (Published 21 May 1949) Cite ...
more infohttp://www.bmj.com/content/1/4611/911.5

Basal Cell Skin CarcinomaBasal Cell Skin Carcinoma

Basal cell carcinomas are slow growing and it is rare for them to metastasize. This provides an opportunity for a therapeutic ... The use of topical vitamin C to kill basal cell carcinoma has been known at least since 1971. Frederick R. Klenner, MD, wrote ... OMNS Nov 9 2007) The most common form of skin cancer, basal cell carcinoma, often responds to a remarkably simple, safe, at- ... Another patient reported that after dermatologist-diagnosed multiple spots of basal cell carcinoma were coated with vitamin C, ...
more infohttp://www.doctoryourself.com/basal.html?fbclid=IwAR2Vbz1pMmAl241Lz7z9pjm9qpFL53S2H7UQ8whAwItdjZNxv4oyZcvVyJc

Basal Cell Carcinoma | MicroscopyUBasal Cell Carcinoma | MicroscopyU

... basal cell carcinoma may grow slowly at first, but like other malignant cancer cells, can spread to other parts of the body ( ... Basal Cell Carcinoma. Basal Cell Carcinoma. A common form of skin cancer (90 percent of the cases), basal cell carcinoma may ... grow slowly at first, but like other malignant cancer cells, can spread to other parts of the body (metastasize). It is ...
more infohttps://www.microscopyu.com/gallery-images/basal-cell-carcinoma

Basal Cell Carcinoma by Mansoor Khan | WaterstonesBasal Cell Carcinoma by Mansoor Khan | Waterstones

Buy Basal Cell Carcinoma by Mansoor Khan from Waterstones today! Click and Collect from your local Waterstones or get FREE UK ... Basal Cell Carcinoma (Paperback). Mansoor Khan (author) Sign in to write a review ...
more infohttps://www.waterstones.com/book/basal-cell-carcinoma/mansoor-khan/9783659176616

Basal-cell carcinoma - WikipediaBasal-cell carcinoma - Wikipedia

Nevoid basal-cell carcinoma syndrome Cystic basal cell carcinoma Micronodular basal cell carcinoma Superficial basal cell ... Cicatricial basal cell carcinoma (also known as "morpheaform basal cell carcinoma," and "morphoeic basal cell carcinoma") is an ... squamous cell carcinoma. In a small proportion of cases, basal cell carcinoma also develops as a result of basal cell nevus ... Pore-like basal cell carcinoma resembles an enlarged pore or stellate pit. Aberrant basal cell carcinoma is characterized by ...
more infohttps://en.wikipedia.org/wiki/Basal-cell_carcinoma

Basal Cell Carcinoma of the Anal Margin | SpringerLinkBasal Cell Carcinoma of the Anal Margin | SpringerLink

It consists of basaloid cells, and on microscopic examination, it is similar to conventional basal cell carcinoma of the... ... Basal cell carcinoma of the anal margin is a malignant epithelial neoplasm. ... Some patients have multiple basal cell carcinomas at other anatomic sites and the diagnosis of basal cell carcinoma of the anal ... Basal cell carcinoma of the anal margin is a malignant epithelial neoplasm. It consists of basaloid cells, and on microscopic ...
more infohttps://link.springer.com/referenceworkentry/10.1007%2F978-3-319-40560-5_2866

Basal Cell Carcinoma | Everyday HealthBasal Cell Carcinoma | Everyday Health

... is a type of skin cancer that begins in the basal cells - cells within the skin that produce new skin cells as old ones die off ... Basal cell carcinoma (BCC) is a type of skin cancer that begins in the basal cells - cells within the skin that produce new ... Basal cell carcinoma, squamous cell carcinoma, and melanoma make up the vast majority of all skin cancers. ... What Is Basal Cell Carcinoma?. The most common type of skin cancer, BCC usually responds well to treatment. ...
more infohttps://www.everydayhealth.com/skin-cancer/guide/basal-cell-carcinoma/

Basal Cell Carcinoma | MercyBasal Cell Carcinoma | Mercy

There are multiple treatment options available for basal cell carcinoma, depending on the specific diagnosis. The cancer team ... Basal cell carcinoma is a very common, treatable form of skin cancer. ... Basal cell carcinoma is a very common type of skin cancer. In fact, every year more people get basal cell carcinoma than any ... This process couldnt take place without basal cells.. However, if cancer invades your basal cells, the cancerous cells ...
more infohttps://www.mercy.net/service/basal-cell-carcinoma/

Basal Cell Carcinoma Risk Factors | MoffittBasal Cell Carcinoma Risk Factors | Moffitt

Learn about the different factors that can increase your likelihood of developing basal cell carcinoma. Moffitt Cancer Center ... Some people are also born with a genetic predisposition to basal cell carcinoma. People with a family history of skin cancer ... Researchers have also found that men are more likely to develop basal cell carcinoma than women and that few people are ... Its impossible to say with certainty who will develop basal cell carcinoma and why; in fact, some people develop the cancer ...
more infohttps://moffitt.org/cancers/basal-cell-carcinoma/diagnosis/risk-factors/

Basal cell carcinoma - Symptoms and causes - Mayo ClinicBasal cell carcinoma - Symptoms and causes - Mayo Clinic

Basal cell carcinoma - Comprehensive overview covers symptoms, treatment, prevention of this common skin cancer that often ... Basal cell carcinoma. Basal cell carcinoma. Basal cell carcinoma is a type of skin cancer that most often develops on areas of ... Basal cell carcinoma is a type of skin cancer. Basal cell carcinoma begins in the basal cells - a type of cell within the skin ... Complications of basal cell carcinoma can include:. *A risk of recurrence. Basal cell carcinomas commonly recur. Even after ...
more infohttps://www.mayoclinic.org/diseases-conditions/basal-cell-carcinoma/symptoms-causes/syc-20354187

Which pills are used to treat basal cell carcinoma?Which pills are used to treat basal cell carcinoma?

... youre most likely to get this drug if your basal cell carcinoma has spread to other parts of your body. ... Which pills are used to treat basal cell carcinoma?. ANSWER There is also a pill that your doctor might prescribe called ... How are creams used to treat basal cell carcinoma?. NEXT QUESTION: How can checking your skin lower your chance of getting ... How does using sunscreen lower your chance of getting basal cell carcinoma again? ...
more infohttps://www.webmd.com/melanoma-skin-cancer/qa/which-pills-are-used-to-treat-basal-cell-carcinoma

Neglected Basal Cell Carcinomas in the 21st CenturyNeglected Basal Cell Carcinomas in the 21st Century

Table 1: Data on the neglected BCC patients and their treatment (BCC: basal cell carcinoma, SCC: squamous cell carcinoma). ... Neglected Basal Cell Carcinomas in the 21st Century. Erika Varga,1 Irma Korom,1 Zoltán Raskó,2 Erika Kis,1 János Varga,1 Judit ... Basal cell carcinoma (BCC) is the most common cutaneous tumor and one of the most frequent skin diseases observed by ... Basal cell carcinoma (BCC), the most common cutaneous tumor, usually develops in the elderly, grows slowly, and has an ...
more infohttps://www.hindawi.com/journals/jsc/2011/392151/