Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Cell Line, Tumor: A cell line derived from cultured tumor cells.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Breast Neoplasms: Tumors or cancer of the human BREAST.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Carcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Mouth Neoplasms: Tumors or cancer of the MOUTH.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Stomach Neoplasms: Tumors or cancer of the STOMACH.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)DNA, Neoplasm: DNA present in neoplastic tissue.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Tongue Neoplasms: Tumors or cancer of the TONGUE.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Time Factors: Elements of limited time intervals, contributing to particular results or situations.RNA, Neoplasm: RNA present in neoplastic tissue.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Transplantation, Heterologous: Transplantation between animals of different species.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Chemoembolization, Therapeutic: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Thyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Rectal Neoplasms: Tumors or cancer of the RECTUM.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)Tumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Urothelium: The epithelial lining of the URINARY TRACT.Vulvar Neoplasms: Tumors or cancer of the VULVA.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Carcinoma, Giant Cell: An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Niacinamide: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.Cell Line: Established cell cultures that have the potential to propagate indefinitely.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Benzenesulfonates: Organic salts and esters of benzenesulfonic acid.Ureteral Neoplasms: Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Mice, Inbred BALB CUp-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Nephrectomy: Excision of kidney.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Adenoma, Oxyphilic: A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Adenocarcinoma, Scirrhous: An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)Eyelid Neoplasms: Tumors of cancer of the EYELIDS.Chromosomes, Human, Pair 3: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Carcinoma, Ehrlich Tumor: A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Cystadenocarcinoma, Papillary: An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.Ampulla of Vater: A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Neoplasms, Squamous Cell: Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.Carcinoma, Skin Appendage: A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)Common Bile Duct Neoplasms: Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Polymorphism, Single-Stranded Conformational: Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.Pharyngeal Neoplasms: Tumors or cancer of the PHARYNX.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Cytological diagnosis of adenoid cystic carcinoma breast--a case report. (1/324)

The cytologic features of a case of adenoid cystic carcinoma of breast diagnosed on fine needle aspiration cytology (FNAC) in a 52 years old female are described. FNAC was carried out on outer quadrant of breast. The characteristic cytological features were numerous single to branching small round to Avoid cells at places forming microacini. Numerous pink hyaline globules of variable sizes were seen along with finger like projections containing basement membrane material.  (+info)

Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study. (2/324)

OBJECTIVES: To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. MAIN OUTCOME MEASURES: Demographic data, cancer T- and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. RESULTS: Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. CONCLUSIONS: The N-stage is the main prognostic factor of overall survival, relapse- and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.  (+info)

Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. (3/324)

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.  (+info)

Novel DNA copy number losses in chromosome 12q12--q13 in adenoid cystic carcinoma. (4/324)

In order to find common genetic abnormalities that may identify loci of genes involved in the development of adenoid cystic carcinoma (ACC), we investigated DNA copy number changes in 24 of these tumors by comparative genomic hybridization (CGH). Our results indicate that unlike many carcinomas, ACCs have relatively few changes in DNA copy number overall. Twenty tumors had DNA copy number changes, which were mostly restricted to a few chromosomal arms. A frequent novel finding was the loss of DNA copy number in chromosome 12q (eight tumors, 33%) with the minimal common overlapping region at 12q12--q13. Deletion in this region has not been reported to be frequent in other types of cancer analyzed by CGH. In addition, deletions in 6q23-qter and 13q21--q22 and gains of chromosome 19 were observed in 25% to 38% of ACCs. Deletion of 19q, previously reported in a small series of ACC, was not identified in the current group of carcinomas. The current CGH results for chromosomes 12 and 19 were confirmed by microsatellite allelotyping. These results indicate that DNA copy number losses in 12q may be important in the oncogenesis of ACC and suggest that the 12q12--q13 region may harbor a new tumor-suppressor gene.  (+info)

Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours. (5/324)

AIM: The gene for familial cylindromatosis (CYLD) has been localised to chromosome 16q, and has recently been cloned. Loss of heterozygosity (LOH) at 16q has also been demonstrated in sporadic cylindromas. The aim of this study was to investigate whether CYLD plays a role in the development of other skin appendage tumours. METHODS: A total of 55 cases of skin adnexal tumours, comprising 12 different types, and a control group of 14 squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) were studied. Three microsatellites (D16S407 (16p), D16S304 (16q), and D16S308 (16q)) were analysed for LOH after microdissection from paraffin wax embedded sections using laser capture microdissection. RESULTS: In keeping with previous data, a proportion of cylindromas exhibited LOH at markers on 16q, but not at 16p. The skin adnexal tumours showing a similar pattern included apocrine hydrocystomas, eccrine spiradenomas, and sebaceous adenoma. One case of syringoma showed LOH at 16q, and a further case at 16p, but not 16q. One case of eccrine hydrocystoma showed loss at 16p, but not 16q. The remaining tumours were either negative or non-informative. All tumours in the control group were either negative or non-informative, except for a single case of BCC showing LOH at 16q. CONCLUSION: CYLD may be involved in the development of skin adnexal tumours other than cylindromas.  (+info)

Bronchial sleeve resection with complete preservation of the lung for carcinoma. (6/324)

Conservative sleeve resection with complete preservation of the lung parenchyma is very rarely applicable for the treatment of bronchial carcinomas. We used this surgical procedure in four patients with bronchial carcinoma in various sites of the central airway, and we obtained successful results. The pathological types were two squamous cell carcinomas and two low-grade malignant tumors (mucoepidermoid carcinoma and adenoid cystic carcinoma). If patients are properly selected, this operative procedure appears to be a safe and radical therapeutic option for the treatment of bronchial neoplasms arising from major bronchi.  (+info)

Radiologic-pathologic correlation of unusual lingual masses: Part II: benign and malignant tumors. (7/324)

Because the tongue is superficially located and the initial manifestation of most diseases occurring there is mucosal change, lingual lesions can be easily accessed and diagnosed without imaging analysis. Some lingual neoplasms, however, may manifest as a submucosal bulge and be located in a deep portion of the tongue, such as its base; their true characteristics and extent may be recognized only on cross-sectional images such as those obtained by CT or MRI. Some uncommon tongue neoplasms may have characteristic radiologic features, thus permitting quite specific radiologic diagnosis. Lipomas typically manifest at both CT and MR imaging as homogeneous nonenhancing lesions. Relative to subcutaneous fat they are isoattenuating on CT images, and all MR sequences show them as isointense. Due to the paramagnetic properties of melanin, metastases from melanotic melanoma usually demonstrate high signal intensity on T1-weighted MR images and low signal intensity on T2-weighted images. Although the radiologic findings for other submucosal neoplasms are nonspecific, CT and MR imaging can play an important role in the diagnostic work-up of these unusual tumors. Delineation of the extent of the tumor, and recognition and understanding of the spectrum of imaging and the pathologic features of these lesions, often help narrow the differential diagnosis.  (+info)

Defective laminin 5 processing in cylindroma cells. (8/324)

Cylindromas are benign skin tumors occurring as multiple nodules characteristically well circumscribed by an excess of basement membrane-like material. To determine the molecular defects leading to extracellular matrix accumulation, the ultrastructural, immunological, and biochemical properties of cylindroma tissue and isolated cells were analyzed. In cylindromas, hemidesmosomes are reduced in number, heterogeneous and immature compared to the normal dermal-epidermal junction. Expression of the alpha6beta4 integrin in tumor cells is weaker than in basal keratinocytes of the epidermis. Moreover, although in the epidermis alpha2beta1-integrin expression is restricted to the basal cell layer, it is found in all neoplastic cells within the nodules. Laminin 5 is present throughout the whole thickness of the basement membrane-like zone whereas laminin 10 is restricted to the interface adjacent to the tumor cells. Furthermore, laminin 5 is not properly processed and most of the alpha3A and gamma2 laminin chains remain as 165-kd and 155-kd polypeptides, respectively. Mature laminin 5 is thought to be necessary for correct hemidesmosome and basement membrane formation and its abnormal processing, as well as the low expression of alpha6beta4 integrins, could explain the lack of mature hemidesmosomes. Together, the results show that multiple molecular defects, including alteration of laminin 5 and its integrin receptors, contribute to structural aberrations of the basement membrane and associated structures in cylindromas.  (+info)

*Adenoid cystic carcinoma

... Research Foundation FAQ for patients at Adenoid Cystic Carcinoma Organization International Adenoid ... Cystic Carcinoma Information Cancer.Net: Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma at Oral Cancer Foundation [2] Search ... Adenoid cystic carcinoma (sometimes referred to as adenocyst, malignant cylindroma, adenocystic, adenoidcystic, ACC or AdCC.) ... Primary cutaneous adenoid cystic carcinoma Collagenous spherulosis Marchiò C, Weigelt B, Reis-Filho JS (Mar 2010). "Adenoid ...

*Primary cutaneous adenoid cystic carcinoma

... is a cutaneous condition characterized by a tumor that usually presents on the chest ... "Primary cutaneous adenoid cystic carcinoma". J. Am. Acad. Dermatol. 58 (4): 636-41. PMID 18342709. doi:10.1016/j.jaad.2007.12. ... Primary cutaneous adenoid cystic carcinomas have been misinterpreted as metastatic lesions. It was characterized in 1975. ... Aggressive digital papillary adenocarcinoma Mucinous carcinoma Skin lesion James, William D.; Berger, Timothy G.; et al. (2006 ...

*Ceruminous adenocarcinoma

... ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/ ... NOS Ceruminous adenoid cystic carcinoma Ceruminous mucoepidermoid carcinoma All of the tumors are infiltrative into the soft ... Dong, F.; Gidley, P. W.; Ho, T.; Luna, M. A.; Ginsberg, L. E.; Sturgis, E. M. (2008). "Adenoid Cystic Carcinoma of the External ... Aikawa, H.; Tomonari, K.; Okino, Y.; Hori, F.; Ueyama, T.; Suenaga, S.; Bundo, J.; Tsuji, K. (1997). "Adenoid cystic carcinoma ...

*Sialoblastoma

It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... Dardick, I.; Daley, T. D.; McComb, R. J. (2010). "Sialoblastoma in adults: Distinction from adenoid cystic carcinoma". Oral ...

*Gabriele Grunewald

She has been diagnosed and treated for cancer twice, first for adenoid cystic carcinoma of the salivary gland in 2009, then for ... Grunewald was diagnosed with adenoid cystic carcinoma in 2009. Due to tumors, her salivary gland was removed in 2009 and her ...

*Santosh G. Honavar

Primary adenoid cystic carcinoma: an extremely rare eyelid tumor. Ophthal Plast Reconstr Surg. 2012 Mar-Apr;28(2):e35-6. 84. ... Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker. Histopathology. 2013 ... Basal cell carcinoma of the eyelid associated with Gorlin-Goltz syndrome. Ophthalmology. 2001 Jun;108(6):1115-23. 181. Honavar ... Rath S, Honavar SG, Reddy VA, Naik MN, Vemuganti GK, Murthy R. Sebaceous carcinoma of the eyelid metastasizing to the lacrimal ...

*Laryngotracheal stenosis

49: 43-4. Kokturk N, Demircan S, Kurul C, Turktas H (2004). "Tracheal adenoid cystic carcinoma masquerading asthma: a case ... Kokturk N, Demircan S, Kurul C, Turktas H (October 2004). "Tracheal adenoid cystic carcinoma masquerading asthma: a case report ...

*Fast neutron therapy

Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands. International Journal of Radiation Oncology*Biology ... Bull Cancer Radiother 83 (Suppl): 125-9s, 1996 See also the NCI Salivary Cancer Page Adenoid Cystic Carcinoma Neutron Radiation ... 2137 Results of fast neutron therapy of adenoid cystic carcinoma of the salivary glands. International Journal of Radiation ... Adenoid cystic carcinomas have also been treated. Various other head and neck tumors have been examined. No cancer therapy is ...

*Epithelial-myoepithelial carcinoma

The histologic differential diagnosis includes adenoid cystic carcinoma and pleomorphic adenoma. They generally have a good ... Epithelial-myoepithelial carcinoma, abbreviated EMCa, is a rare malignant tumour that typically arises in a salivary gland and ... Epithelial-myoepithelial carcinoma of the lung Adenomyoepithelioma Intermed. mag. High mag. Kasper, HU.; Mellin, W.; Kriegsmann ... Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands ...

*Artemis Hospital

Successfully cured a rare cancer called Adenoid Cystic Carcinoma of Trachea. Asia Pacific Hand hygiene excellence Award in 2011 ...

*Apocrine gland carcinoma

Eccrine carcinoma Primary cutaneous adenoid cystic carcinoma Skin lesion James, William D.; Berger, Timothy G.; et al. (2006). ... Apocrine gland carcinoma is a cutaneous condition characterized by skin lesions which form in the axilla or anogenital regions ...

*Ceruminous gland

The malignant tumors include ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. List of ...

*Wendi Andriano

After many misdiagnoses, Joe was finally diagnosed with adenoid cystic carcinoma in 1998. At that time his illness had become ...

*Super-enhancer

March 2016). "An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma". Nature Genetics. 48 (3 ...

*Polymorphous low-grade adenocarcinoma

Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. PLGAs are treated ...

*Tracheal tumor

Among these, the most common are the squamous-cell carcinoma and the adenoid cystic carcinoma. Ferretti GR, Bithigoffer C, ...

*Gervase Markham (programmer)

Markham is a born-again Christian, and has been undergoing treatment for metastatic adenoid cystic carcinoma. He has written ...

*Cindy Marano

At the time of her death in 2005 from adenoid cystic carcinoma she lived in Oakland, California. She lived in Washington, D.C. ...

*ERBB3

1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... Lee H, Maihle NJ (1998). "Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma- ... 1995). "Prognostic significance of ERBB3 overexpression in oral squamous cell carcinoma". Cancer Lett. 95 (1-2): 79-83. doi: ... kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells". Cancer Res ...

*Parotid gland

... with the most common tumors being mucoepidermoid carcinoma and adenoid cystic carcinoma. Other malignant tumors of the parotid ... squamous cell carcinoma (arising from parenchyma of parotid gland), and undifferentiated carcinoma. Metastasis from other sites ... gland include acinic cell carcinoma, carcinoma expleomorphic adenoma, adenocarcinoma (arising from ductal epithelium of parotid ...

*Orbit (anatomy)

... lymphoma or adenoid cystic carcinoma). Tumors (e.g. glioma and meningioma of the optic nerve) within the cone formed by the ...

*Bartholin gland carcinoma

... adenoid cystic carcinoma, or adenocarcinomas. Though Bartholin gland carcinoma is rare, along with other unusual Bartholin ... The Adenoid cystic carcinoma of the Bartholin gland is another uncommon malignancy with symptoms that include local painful ... Bartholin gland carcinoma is an uncommon type of malignancy in the Bartholin gland that accounts for 1% of all vulvar malignant ... Bartholin gland can be differentiated by histology to determine whether the malignancy is due to squamous cell carcinoma, ...

*MMP15

2006). "[Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using ...

*Mucinous carcinoma

Eccrine carcinoma Microcystic adnexal carcinoma Primary cutaneous adenoid cystic carcinoma List of cutaneous conditions ... Mucinous carcinoma is a type of cancer that arises from epithelial cells; these line certain internal organs and skin, and ... Mucinous carcinoma entry in the public domain NCI Dictionary of Cancer Terms. ... produce mucin (the main component of mucus).[citation needed] When found within the skin, mucinous carcinoma is commonly a ...

*Collagenous spherulosis

... and adenoid cystic carcinoma. Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular ... It is important to correctly identify, as it can be confused with atypical ductal hyperplasia, cribriform ductal carcinoma in ...

*Cylindroma

Types include: Dermal eccrine cylindroma, a benign tumour of the skin Adenoid cystic carcinoma, a malignant tumour of the ...
TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference ( ...
Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period.. In prospectively performed clinical trials, objective responses to any cytotoxic agent or regimen are infrequent, whereas stabilization of disease was observed more commonly.. In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare.. According to Younes MN et als study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. And when treated with EGFR/VEGFR TK dual inhibitor, the phosphorylated form of Akt decreased despite of total level of Akt is remained unchanged.. When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an ...
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic ...
In a single-center phase II study reported in the Journal of Clinical Oncology, Tchekmedyian et al found that the multitargeted tyrosine kinase inhibitor lenvatinib was active in progressive recurrent or metastatic adenoid cystic carcinoma.. Study Details. In the study, 32 evaluable patients at Memorial Sloan Kettering Cancer Center with recurrent or metastatic adenoid cystic carcinoma of any primary site and radiographic or symptomatic progression were treated with lenvatinib 24 mg orally per day. Any prior therapy except lenvatinib was allowed.. The primary endpoint was overall response rate. The study was to be considered positive if 4 or more responses occurred among a total of 32 patients. Overall, 78% of patients had adenoid cystic carcinoma of either the major or minor salivary glands, and 96.9% had distant metastases.. Responses. Five patients (15.6%) had confirmed objective response (all partial responses) and an additional 24 patients (75.0%) had stable disease. Median progression-free ...
Treatment with novel radiotherapeutic technologies could increase local control in adenoid cystic carcinoma of the head and neck. Especially combined treatment with intensity-modulated radiation therapy and heavy ion (C12) boost to the primary tumor or previous tumor bed could be established as the treatment of choice in this disease.. Unfortunately, therapeutic results in the treatment of adenoid cystic carcinoma are still hampered by the occurrence of distant metastases (predominantly in the lungs) which, though progressing comparatively slowly, still limit the patients life expectancy. Most adenoid cystic carcinomas (, 80%) though, exhibit over-expression of EGFR receptors and hence provide an approach for systemic treatment. In this prospective phase II trial, the application of the EGFR antibody cetuximab will be evaluated in combination with the established treatment of intensity-modulated radiation therapy plus C12 heavy ion boost.. The trial aims at evaluation of toxicity and ...
Adenoid cystic carcinoma is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In a brief report published on 17 June 2013 in theJournal of Clinical Investigation, researchers led by Andrew Futreal of the Cancer Genome Project, Wellcome Trust Sanger Institute in Cambridge, United Kingdom, reported on a whole exome sequencing performed in 24 adenoid cystic carcinoma cases.. They uncovered the involvement of multiple cancer genes that are likely to be contributing to tumour development in the context of MYB activation. The data point to disruption of chromatin regulation as a major factor in adenoid cystic carcinoma development. Furthermore, the data implicate NOTCH signalling deregulation in a proportion of cases. Finally, the analysis has identified activating mutations of the receptor tyrosine kinase FGFR2 in ...
TY - JOUR. T1 - AKT3 drives adenoid cystic carcinoma development in salivary glands. AU - Zboray, Katalin. AU - Mohrherr, Julian. AU - Stiedl, Patricia. AU - Pranz, Klemens. AU - Wandruszka, Laura. AU - Grabner, Beatrice. AU - Eferl, Robert. AU - Moriggl, Richard. AU - Stoiber, Dagmar. AU - Sakamoto, Kazuhito. AU - Wagner, Kay Uwe. AU - Popper, Helmut. AU - Casanova, Emilio. AU - Moll, Herwig P.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic ...
Kimberly Smith admired her brother-in-law for his kindness and thoughtfulness, as well as his courageous fight with stage IV adenoid cystic carcinoma (ACC), a rare cancer, when he was only 26 and newly married. In his honor, the family established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research at MD Anderson.
Adenoid cystic carcinomas are a rare histological subtype of adenocarcinoma. Pathology Adenoid cystic carcinomas are generally considered low grade 4. The tumours have a notable tendency for perineural spread. Location They have a wide distri...
Adenoid cystic carcinoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
15. NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway SCOPUS SCIE 作者:Gao, Xiao-lei; Zheng, Min; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Li, Li; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Tang, Ya-Jie; Liang, Xin-hua; Tang, Ya-ling. 作者机构:[Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Zheng, Min; Li, Li] Wenzhou Med Univ, Zhoushan Hosp, Dept ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of "hybrid carcinomas" that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Adenoid Cystic Carcinoma: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of MYB gene rearrangements and MYB-NFIB chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. MYB and TLN2 were affected by somatic mutations in two
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
PURPOSE: To study the effect of hepatitis B virus X protein binding protein (HBXIP) on proliferation, migration and invasion of adenoid cystic carcinoma cell line ACC-M, and the possible mechanism of PI3K/Akt signaling pathway. METHODS: HBXIP plasmid was transfected into ACC-M. The cells were divided into experimental group (transfected with plasmid pEGFP-N1-HBXIP) control group (non-transfected group) and blank control group (vector group, pEGFP-N1). RT-PCR was used to detect the expression HBXIP in ACC-M; MTT assay, transwell chamber experiments and scratches over the proliferation of HBXIP were utilized individually to evaluate the influence of HBXIP on ACC-M expression, migration and invasion; Western blotting was used to detect the protein expression of Akt, p-Akt, PI3K, p-PI3K and S100A4 after overexpression of HBXIP ...
Li, N., Xu, L., Zhao, H., El-Naggar, A. K. and Sturgis, E. M. (2012), A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer, 118: 3945-3953. doi: 10.1002/cncr.26740 ...
Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals. Controversy exists as to the benefit of regularly following asymptomatic patients to look for distant metastases because even if one is found, the options for further management are limited. When a metastasis is limited to the lung in an asymptomatic patient with no locoregional recurrence, metastasectomy might provide some long-term benefit, although we cannot know for certain. We encountered such a case, and we opted for surgical resection rather than a conservative approach. There is a need for multicenter trials so that the management of such patients, be it active or conservative, can be evidence-based.. ...
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at di …
Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer. Epidemiology They account for only 0.1-0.4% of all breast cancers. Pathology The tumour demonstrates a strikingly characteristic microscopic pattern similar to t...
目的:探讨外耳道腺样囊性癌的临床及病理特点,以提高诊断和治疗水平。方法:回顾性分析1例外耳道腺样囊性癌患者自首诊8年来连续的临床表现,病程进展,治疗及随访结果。结果:患者术后随访半年无复发。结论:外耳道腺样囊性癌生长缓慢,可长期带瘤生存但远期预后不佳,首次治疗应该采用扩大根治性手术,术后结合临床病理分期辅以放射治疗以提高治愈率。 Objective: To detect the clinical and pathological features of the adenoid cystic carcinoma of external audi-tory canal, and to improve its diagnosis and treatment level. Method: A retrospective analysis has been performed on patients with ACCEAC by their clinical manifestation, the therapy and follow-up results since 8 years ago as well as the combination with there view of related literature. Result: Patients without recurrence of postoperative follow-up of six months. Conclusion: Adenoid cystic carcinoma of external
This is Cancer.Nets Guide to Adenoid Cystic Carcinoma. Use the menu below to choose the Introduction section to get started. Or, you can choose another section to learn more about a specific question you have. Each guide is reviewed by experts on the Cancer.Net Editorial Board, which is composed of medical, surgical, radiation, gynecologic, and pediatric oncologists, oncology nurses, physician assistants, social workers, and patient advocates.. ...
TY - JOUR. T1 - The mutational landscape of adenoid cystic carcinoma. AU - Ho, A.S.. AU - Kannan, K.. AU - Roy, D.M.. AU - Morris, L.G.T.. AU - Ganly, I.. AU - Katabi, N.. AU - Ramaswami, D.. AU - Walsh, L.A.. AU - Eng, S.. AU - Huse, J.T.. AU - Zhang, J.N.. AU - Dolgalev, I.. AU - Huberman, K.. AU - Heguy, A.. AU - Viale, A.. AU - Drobnjak, M.. AU - Leversha, M.A.. AU - Rice, C.E.. AU - Singh, B.. AU - Iyer, N.G.. AU - Leemans, C.R.. AU - Bloemena, E.. AU - Ferris, R.L.. AU - Seethala, R.R.. AU - Gross, B.E.. AU - Liang, Y.P.. AU - Sinha, R.. AU - Peng, L.K.. AU - Raphael, B.J.. AU - Turcan, S.. AU - Gong, Y.X.. AU - Schultz, N.. AU - Kim, S.. AU - Chiosea, S.. AU - Shah, JP. AU - Sander, C. AU - Lee, W.. AU - Chan, T.A.. PY - 2013. Y1 - 2013. U2 - 10.1038/ng.2643. DO - 10.1038/ng.2643. M3 - Article. VL - 45. SP - 791. EP - 798. JO - Nature Genetics. JF - Nature Genetics. SN - 1061-4036. IS - 7. ER - ...
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis Chunliu Ning,1 Tengfei Zhao,1 Zechen Wang,1 Delong Li,1 Yurong Kou,2 Shaohui Huang1 1Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China Background: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. Materials and methods: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3.
Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck This study is currently recruiting participants. Verified March 2012 by University of Iowa…
Discover natural remedies to help in the treatment of adenoid cystic carcinoma, such as acupuncture, hydrogen peroxide therapy and Vitamin B-17.
Background:. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrated that Pim-1 phosphorylates RUNX3 and alters its subcellular localization. As a highly malignant tumor, salivary adenoid cystic carcinoma (ACC) accounts for approximately 10% of all epithelial salivary tumors and the 5-year survival rate of patients with highly metastatic ACC is less than 20%. However, few studies have concerned the implications of Pim-1 in the salivary ACC.. Aim:. In this study, we aimed to clarify the function of Pim-1 in ACC cell lines in vitro. Meanwhile, we measure the levels of Pim-1 and RUNX3 in the ACC tissues. The correlations between Pim-1/RUNX3 levels and clinical parameters were also analyzed. Methods:. SACC-83 and SACC-LM cells were transfected with the Pim-1 siRNA. Pim-1 mRNA and protein expression were measured using real-time PCR and immnuoblot, ...
Tumors of the lacrimal gland constitute less than 5% of all biopsied orbital lesions [3, 4]. The most common epithelial malignancy is primary adenoid cystic carcinoma; adenocarcinoma is rare, representing only 5 to 7% of epithelial tumors of the lacrimal gland [2-6]. Because there is no specific histopathologic classification for lacrimal gland tumors, they are often classified according to the histological classification of salivary gland tumors with which they share many similarities [1, 3, 7].. This subtype of lacrimal gland, adenocarcinoma, was described for the first time in 1996 by Katz et al. [2]. Since then, most reports in the literature are case reports describing an aggressive clinical pattern and poor prognosis [1, 2, 8].. The tumor usually begins in the upper eyelid as a growth and is accompanied by clinical symptoms such as lid pseudoptosis, exophthalmos, dystopia, pain, and reduced visual acuity [4, 6].. The patients short life expectancy after surgical treatment for ...
Ceruminous adenocarcinoma is a malignant neoplasm derived from ceruminous glands of the external auditory canal. This tumor is rare, with several names used in the past. Synonyms have included cylindroma, ceruminoma, ceruminous adenocarcinoma, not otherwise specified (NOS), ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/2 of the external auditory canal as a primary site. If this area is not involved, the diagnosis should be questioned. The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common symptom, followed by either sensorineural or conductive hearing loss, tinnitus or drainage (discharge). A mass lesion may be present, but it is often slow growing. Imaging studies are used to define the extent of the tumor and to exclude direct extension from the parotid gland or nasopharynx. The imaging findings are usually non-specific, and cannot give a ...
Background Tracheal tumors are often misdiagnosed as asthma and are treated with inhaled steroids and bronchodilators without resolution.
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.METHODS An integrated genomic analysis of 1,045 ACCs (177 primary, 868 R/M) was performed to identify alterations associated with advanced and metastatic tumors. Intratumoral genetic heterogeneity, germline mutations, and therapeutic actionability were assessed.RESULTS Compared with primary tumors, R/M tumors were enriched for alterations in key Notch (NOTCH1, 26.3% vs. 8.5%; NOTCH2, 4.6% vs. 2.3%; NOTCH3, 5.7% vs. 2.3%; NOTCH4, 3.6% vs. 0.6%) and chromatin-remodeling (KDM6A, 15.2% vs. 3.4%; KMT2C/MLL3, 14.3% vs. 4.0%; ARID1B, 14.1% vs. 4.0%) genes. TERT promoter mutations (13.1% of R/M cases) were mutually exclusive with both ...
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.METHODS An integrated genomic analysis of 1,045 ACCs (177 primary, 868 R/M) was performed to identify alterations associated with advanced and metastatic tumors. Intratumoral genetic heterogeneity, germline mutations, and therapeutic actionability were assessed.RESULTS Compared with primary tumors, R/M tumors were enriched for alterations in key Notch (NOTCH1, 26.3% vs. 8.5%; NOTCH2, 4.6% vs. 2.3%; NOTCH3, 5.7% vs. 2.3%; NOTCH4, 3.6% vs. 0.6%) and chromatin-remodeling (KDM6A, 15.2% vs. 3.4%; KMT2C/MLL3, 14.3% vs. 4.0%; ARID1B, 14.1% vs. 4.0%) genes. TERT promoter mutations (13.1% of R/M cases) were mutually exclusive with both ...
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. Recurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies. To improve outcomes, deeper understanding of genetic alterations and vulnerabilities in R/M tumors is needed.METHODS An integrated genomic analysis of 1,045 ACCs (177 primary, 868 R/M) was performed to identify alterations associated with advanced and metastatic tumors. Intratumoral genetic heterogeneity, germline mutations, and therapeutic actionability were assessed.RESULTS Compared with primary tumors, R/M tumors were enriched for alterations in key Notch (NOTCH1, 26.3% vs. 8.5%; NOTCH2, 4.6% vs. 2.3%; NOTCH3, 5.7% vs. 2.3%; NOTCH4, 3.6% vs. 0.6%) and chromatin-remodeling (KDM6A, 15.2% vs. 3.4%; KMT2C/MLL3, 14.3% vs. 4.0%; ARID1B, 14.1% vs. 4.0%) genes. TERT promoter mutations (13.1% of R/M cases) were mutually exclusive with both ...
The underlying causes of AdCC are still unknown. Researchers have proved that this disorder is not hereditary and is not inherited by a child from the mother. It has also been proved that the common risk factors for cancer, such as drinking alcohol and smoking, are not responsible for this type of cancer.. Naturally, researchers have assumed a working hypothesis regarding its causes. According to this theory, AdCC is caused by various environmental factors responsible for some genetic changes in the normal cells of the body that results in uncontrolled growth. Recently, researchers have found a common genetic change in a number of AdCC tumors. This new fused gene (named MYB-NFIB) is formed as a result of the fusion of the broken number 6 and number 9 chromosomes. This "translocation" is believed to be a key factor in the development of the tumor in many cases of the condition. ...
MeSH-minor] Airway Obstruction / etiology. Airway Obstruction / therapy. Algorithms. Bronchoscopy. Carcinoma, Adenoid Cystic / diagnosis. Carcinoma, Adenoid Cystic / epidemiology. Carcinoma, Adenoid Cystic / therapy. Carcinoma, Squamous Cell / diagnosis. Carcinoma, Squamous Cell / epidemiology. Carcinoma, Squamous Cell / therapy. Cough / etiology. Diagnostic Imaging. Dyspnea / etiology. Hemoptysis / etiology. Humans. Neoplasm Staging. Respiratory Function Tests. Respiratory Sounds / etiology. Survival Rate. Trachea / ...
Our study, the largest to date, identify a novel deletions at the distal region of chromosome 1p in ACC. The loss of chromosome 1p occurred in 44% of the cases and common region was mapped to 1p32-p36. This finding strongly suggests that this region harbor tumor suppressor gene(s) associated with the development of at least a subset of ACCs. In addition, loss of chromosome 1p32-p36 region was correlated significantly with poor outcome in patients with ACC. Interestingly, previous studies of different malignancies have also reported an association between loss of the distal region of chromosome 1p and aggressive tumor behavior and poor outcome (23). Several genes (p73 and CHD5) were identified from 1p36 region and shown to function as tumor suppressor gene. p73 is one of the tumor suppressor genes located at 1p36.3 and shown to be frequently deleted in neuroblastoma and other human cancers (24). The functional studies suggested that transcriptional silencing of this gene by hypermethylation of a ...
Senoo M, Tsuchiya Y, Matsumara Y, et al. Transcriptional dysregulation of the p73L/p63/p51/p40/ket gene in human squamous cell carcinomas: expression of delta Np73L, a novel dominant negative isoform, and loss of expression of the potential tumor suppressor gene p51. Br J Cancer. 2001; 84: 1235-1241 ...
Welcome to the updated version of Pathology for Urologists! This program was designed to help Urology residents and fellows familiarize themselves with the pathologic features of common urologic entities. This will serve not only as a resource tool for your review but also as a quick reference guide to urologic pathology.
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Life is getting in the way, so Im putting this project on hold for awhile. If you follow me on facebook, youll know that we had a kitchen fire at our house Christmas eve. No one was hurt, and the worst of the damage is isolated to the kitchen. At first we were relieved, grabbed some clothes for the kids and thought we would be home soon. Then we started talking to the restoration company. That estimate of weeks turned into months. Theyve been great helping us with all this. They took clothes, and shoes for everyone Christmas eve, and brought them back clean on Christmas day.We took the kids by the house a couple days later. Sometimes your imagination of how bad it is can be worse than reality. I think it was hard for the kids to understand at first that even though their rooms look fine, their toys, their books, the Christmas presents they had just received from us the night before, were all covered in a fine layer of soot. The smell of the smoke permeates everything, even if it looks fine. ...
So this is the fun part, there are a few rules. The cards are 2 1/2 inches by 3 1/2 inches, like a baseball card. Usually, 2 artists would agree to trade either cards they have already finished, or to create cards and a specific theme and then exchange. For this, all the cards were organized into a frame together and displayed at our church. ...
Case Reports in Pathology is a peer-reviewed, Open Access journal that publishes case reports focusing on anatomical pathology, immunopathology, cytopathology, as well as forensic and morbid anatomy.
Besides the standard medicine treatments utilized to deal with cancer, many cancer patients embrace and follow a variety of other techniques and treatments to support their healing. Complementary and Alternative Medicine (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. Conventional medicine is medicine as practiced by holders of M.D. (medical doctor) or D.O. (doctor of osteopathy) degrees and by their allied health professionals, such as physical therapists, psychologists, and registered nurses. Some health care providers practice both CAM and conventional medicine. While some scientific evidence exists regarding some CAM therapies, for most there are key questions that are yet to be answered through well-designed scientific studies - questions such as whether these therapies are safe, and whether they work for the diseases or medical conditions for which they are used. The list of what is ...
We are looking for graduate students or postdocs with experience in bioinformatics to help analyze WGS and RNA sequencing data from our in vivo model systems and set up a queryable database for our website. Flexible hours and free pizza. Send CV to [email protected] ...
We are looking for graduate students or postdocs with experience in bioinformatics to help analyze WGS and RNA sequencing data from our in vivo model systems and set up a queryable database for our website. Flexible hours and free pizza. Send CV to [email protected] ...
Build: Mon Nov 12 13:52:52 EST 2018 (commit: 8a5bcf7). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
Tumor-induced angiogenesis is essential for invasive growth and hematogenous metastasis of adenoid cystic carcinoma (ACC), a highly aggressive neoplasm mostly occurring in salivary glands. Previous studies have indicated that strategies directed against angiogenesis will help develop new therapeutics for ACC. The Chinese folk medicine licorice has been used for years as a natural remedy for angiogenesis-related diseases. Here we examined the effects of isoliquiritigenin (ISL), a flavonoid isolated from licorice, on the growth and viability of ACC cells, and observed a concentration-dependent (0-20 μM) inhibition of cell growth without cell death at 24 h. In a further mimic co-culture study, ISL effectively suppressed the ability of ACC cells to induce in vitro proliferation, migration and tube formation of human endothelial hybridoma (EAhy926) cells as well as ex vivo and in vivo angiogenesis, whereas it exerted no effect on EAhy926 cells when added directly or in the presence of vascular ...
Who is Lisa OHara? Lisa is one courageous gal. In April 2011, aged 23, she was diagnosed with Adenoid Cystic Carcinoma (ACC). Its a rare cancer that for Lisa presented in her salivary gland behind her right ear. Further tests showed it had advanced to bones nearby and down in her lungs. Shes had 15 […]. ...
Adenoid cystic carcinoma: Tends to infiltrate perineural spaces and causes pain. (This well have to remember, unless you submit us a mnemonic! =D ) ...
Background: The Notch pathway plays a key role in embryonic development, the regulation of stem and progenitor cells, and is implicated in human cancer. Notch-1 (N1) signaling is activated by various mechanisms including N1 activating mutations in certain solid tumors. Brontictuzumab (BRON) is a humanized IgG2 antibody that inhibits the signaling function of N1. As such, BRON is a novel anti-cancer agent that inhibits tumor growth through direct actions on tumor cells, including CSCs, and effects on tumor angiogenesis.. Materials and methods: A phase I dose escalation and expansion study was initiated in patients (pts) with certain advanced solid tumors (cholangiocarcinoma, breast (BC), colorectal (CRC), esophageal, gastric, pancreatic, small cell lung cancers (SCLC), and adenoid cystic carcinomas (ACC)) that have rates of N1 activation between 12-50%. BRON was administered intravenously to study safety, pharmacokinetics (PK), pharmacodynamics, preliminary efficacy, and to determine the maximum ...
Today is a day of celebration for me - Its my one year cancerversary!!. I guess Im not really sure how youre supposed to count this sort of thing. Some cancer survivors choose the last day of chemotherapy or radiotherapy as their anniversary. Others select the first clear MRI scan or mammogram. There are also some survivors who choose the date of their surgery for clean margin. For me, I consider my so-called cancerversary to be 29 September - the day I was diagnosed with Adenoid Cystic Carcinoma. You can read about it here. I never thought this day would come, and its through tear-filled eyes that my family and I will remember the last 365 days. Although in some way it seems like it just happened yesterday, in other ways it seems like its been forever! So much had happened since then - Sara had graduated and work with an architect firm, Mom had resigned from a developer and works with a Bank, Amir managed to get 8As for PMR and is now a head boy, Hafez had changed school from ...
Last November, and again this month, I had CT scans, and it turns out my cancer (Adenoid Cystic Carcinoma) has been growing. (If you havent known me for long and didnt know I have cancer, the timeline and in particular the video might be a useful introduction.) I now have lumps of significant size - 2cm or larger - in both of my lungs and in my liver. It has also spread to the space between the lung and the chest wall. It normally doesnt cause much bother there, but it can bind the lung to the wall and cause breathing pain. For the last 14 years, we have been following primarily a surgical management strategy. To this end, I have had approximately 5 neck operations, 2 mouth operations, 2 lung operations, and had half my liver, my gall bladder and my left kidney removed. Documentation about many of these events is available on this blog, linked from the timeline. Given that Im still here and still pretty much symptom-free, I feel this strategy has served me rather well. God is good.. However, ...
Hazkani I, Motiei M, Betzer O, Sadan T, Bragilovski D, Lubimov L, Mizrachi A, Hadar T, Levi M, Ben-Aharon I, Haviv I, Popovtzer R, Popovtzer A. Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma. Theranostics 2017; 7(16):3962-3971. doi:10.7150/thno.19615 ...
Ganapathy V, Manyanga J, Brame L, McGuire D, Sadhasivam B, Floyd E, Rubenstein DA, Ramachandran I, Wagener T, Queimado L. Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage. PLoS One 2017; 12: e0177780.. Wagener TL, Floyd EL, Stepanov I, Driskill LM, Frank SG, Meier E, Leavens EL, Tackett AP, Molina N, Queimado L. Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second- and third-generation electronic cigarette users. Tob Control, Online First Oct 11, 2016; doi:10.1136/tobaccocontrol-2016-053041. PMID: 27729564. Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE. An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet. 2016 Feb 1. doi: 10.1038/ng.3502.. Ganapathy ...
Alzheimers disease (AD) is an irreversible neurodegenerative disorder that accounts for 60% to 70% of cases of dementia in the elderly. An early diagnosis of AD is usually hampered for many reasons including the variable clinical and pathological features exhibited among affected individuals. This paper presents a computer-aided diagnosis (CAD) system with the primary goal of improving the accuracy, specificity, and sensitivity of diagnosis. In this system, PiB-PET scans, which were obtained from the ADNI database, underwent five essential stages. First, the scans were standardized and de-noised. Second, an Automated Anatomical Labeling (AAL) atlas was utilized to partition the brain into 116 regions or labels that served for local (region-based) diagnosis. Third, scale-invariant Laplacian of Gaussian (LoG) was used, per brain label, to detect the discriminant features. Fourth, the regions features were analyzed using a general linear model in the form of a two-sample t-test. Fifth, the support vector
... - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
Blake , PW, Toro , JR. "Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling". Hum Mutat. vol. 30. 2009. pp. 1025-36. (A comprehensive review about the clinical features, molecular genetics, and the animal models of Brooke-Spiegler syndrome.). Layegh , P, Sharifi-Sistani , N, Abadian , M, Moghiman , T. "Brooke-Spiegler syndrome". Indian J Dermatol Venereol Leprol. vol. 74. 2008. pp. 632-4. (A case report describing a patient diagnosed as Brooke-Spiegler syndrome.). Kazakov , DV, Zelger , B, Rütten , A, Vazmitel , M, Spagnolo , DV, Kacerovska , D. "Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome". Am J Surg Pathol. vol. 33. 2009. pp. 705-19. (An article describing a series of 24 malignant neoplasms arising in preexisting benign spiradenoma ...
Learn about salivary gland cancer treatment advances. New radiation therapy technology has resulted in improved treatment of salivary gland cancer.
Treatments for salivary gland cancer include surgery and radiation. Learn about treatment plans and options for salivary gland cancer.
Multiple familial trichoepithelioma (also known as Brooke-Spiegler syndrome and epithelioma adenoides cysticum) is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face. The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene. Types include: Brooke-Spiegler syndrome is a condition where multiple skin tumors develop from skin structures. Tumors commonly occurring in this syndrome include spiradenomas, trichoepitheliomas, and cylindromas. The tumors are generally benign, but may become malignant. Affected individuals are also at increased risk of developing tumors in tissues other than skin - particularly benign or malignant tumors of the salivary glands. Tumours in Brooke-Spiegler typically appear in early adulthood ...
ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Nets Guide to Salivary Gland Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.About the salivary glandsThe salivary glands contain tissues that produce saliva. Saliva is important to the
Most people with salivary gland cancer will have radiation therapy, alone or with other treatments. Learn about radiation therapy for salivary tumours.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Brooke-Spiegler Syndrome. Quyn Sherrod, MD; Miguel Gutierrez, MD; Keith Carlson, MD UCLA/WLA VA Division of Dermatology David Geffen School of Medicine Los Angeles, California. History. 39 year-old, healthy, Caucasian male Multiple lesions on face and scalp beginning at 10 years old...
Examples adenoid cystic carcinoma cribriform adenocarcinoma of minor salivary glands polymorphous adenocarcinoma pleomorphic adenoma (...)
The epidemiology, pathology, clinical presentation, treatment, and prognosis of malignant primary tracheal tumors will be reviewed here.Depending upon histology and location, tracheal tumors may overlap with primary lung cancers or head and neck lesi
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Head and Neck Cancer is a term used to describe a number of different malignant tumours that develop in or around the throat, larynx, nose, sinuses, and mouth.. Most Head and Neck Cancers are Squamous Cell Carcinomas. This type of cancer begins in the flat, squamous cells that make up the thin layer of tissue on the surface of the structures in the head and neck. Directly beneath this lining, which is called the epithelium, some areas of the head and neck have a layer of moist tissue, called the mucosa. If a cancer is limited to the squamous layer of cells, it is called Carcinoma in Situ. If the cancer has grown beyond this cell layer and moved into the deeper tissue, then it is called Invasive Squamous Cell Carcinoma.. If a Head and Neck Cancer starts in the salivary glands, the tumour will usually be classified as an adenocarcinoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma. ...
Neutron therapy is a form of radiotherapy used by radiation oncologists to treat certain types of tumour. Neutrons are sub-atomic particles with different radiobiological properties from photons and protons but similar to carbon ions. Neutrons are used in the treatment of salivary gland (adenoid cystic carcinomas), other head & neck tumours, sarcomas, prostate, breast cancer, mesothelioma, chordomas and rare cancers
Tumor markers are substances found in the blood, urine or body tissues that can be elevated in cancer. There are many different tumor markers. They are used in oncology to help determine the presence of cancer. An elevated level of a tumor marker can indicate cancer, however there can often also be other causes of the elevation.. Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. Tumor markers can be used in screening programs, such as screening for elevated levels of prostate specific antigen (PSA) to indicate possible prostate cancer. Tumor markers are also used to monitor patients for cancer return. Tumor markers can be classified in two groups: Cancer-specific markers and tissue-specific markers.. Adenoid Cystic Carcinoma. Ki- ...
and a 1.6-inch area in the left uterine area that needs to be checked for possible pelvic cancer.. The good news? There is no sign of disease elsewhere, including in my head, lungs, heart and other organs. Yippee! Seriously.. Life can turn on a dime, you know?. I reached for chocolate!. Did you all know Im claustrophobic? That makes all this scanning business quite stressful for me. An MRI is almost out of the question. Honestlly, part of me now believes the worst is over, if they dont make me get in another tube.. Heres the plan right now. Liver surgeon Dr. Qasim Chaudhry is sharing my report with the "Tumor Board" of consulting cancer physicians at Iowa Methodist, who know my internals very well by now. The discussion will probably include surgical removal of the tumors, since adenoid cystic carcinoma just doesnt have a history of responding to chemotherapy. If removal is the next step, this will be my third time having it done. First a golf-ball-sized tumor was removed from my lower ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the "Cheeky Librarian", since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the "Cheeky Librarian", since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
A 51-year-old white man was admitted to the Nemazee Hospital on June 1, 1957, with the chief complaint of difficulty in breathing.He was perfectly well until si
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
View details of top pituitary gland cancer hospitals in Navi Mumbai. Get guidance from medical experts to select best pituitary gland cancer hospital in Navi Mumbai
Learn about this rare form of cancer affecting the salivary glands and salivary gland treatments such as surgery and radiation therapy.
If youre just joining us, here are the Spark Notes:. In September, Carolyn had surgery to remove what we thought was an enlarged lymph node in her jaw that had become painful. We discovered that it was actually a rare, destructive salivary gland cancer. With that news, doctors order a PET scan to determine abnormal activity. In addition to the area of that one salivary gland, the back of her tongue/tonsils and several lymph nodes in her abdomen/groin area showed up as active.. We had known something was up in her abdomen/groin area because for a couple of months prior, shed been experiencing pain and soreness. Doctors had attributed that to enlarged lymph nodes due to sarcoidosis.. After consultation with doctors here in Blacksburg and at Wake Forest Baptist, Carolyn had a second surgery to make sure all the initial salivary gland cancer was removed. At that time they also took tissue from her tongue/tonsils area to study.. That was last Tuesday. On Thursday, she went in to her local ENT here ...
I wondered from time to time what I would do if I ever came Uppitylady1? with a cancer diagnosis. When I did find out I had breast cancer the news was delivered by a gentleman with his hand on the door knob who I felt. couldnt,t get out of the room fast enough. That,s ok with me I wanted to leave too ...
I wondered from time to time what I would do if I ever came Uppitylady1? with a cancer diagnosis. When I did find out I had breast cancer the news was delivered by a gentleman with his hand on the door knob who I felt. couldnt,t get out of the room fast enough. That,s ok with me I wanted to leave too ...
Cancer Therapy Advisor provides oncologists and oncology specialists with the latest information to correctly diagnose the latest cancer conditions, recommend procedures and guides. Visit often for updates and new information.
Cardiology news, research and treatment articles offering cardiology healthcare professionals cardiology information and resources to keep them informed.
Treatment for salivary gland cancer may lead to a number of side effects. Possible side effects depend on the surgical approach that best suits your individual cancer. It depends on whether you need to have lymph nodes removed from the neck. You may not experience all of the side effects. Speak with your doctor if you have any questions or concerns about treatment side effects ...
Cardiology news, research and treatment articles offering cardiology healthcare professionals cardiology information and resources to keep them informed.
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Salivary gland tumors are more likely to be cancerous in children when compared to adults. About half of the salivary gland tumors are cancerous in children. Most of the tumors occur in a salivary gland called parotid gland (located at the angle of the jaw below the ear lobes on both sides). The types of cancerous salivary gland tumors include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma and adenocarcinoma NOS.. ...
Primary tracheal tumors are rare. Population-based studies from tumor registries in Finland, Denmark, Netherlands, and England report annual incidence rates of tracheal cancer of approximately 0.1 per 100,000 per year, with tracheal cancers accounting for less than one-half of 1 percent of all malignant tumors.3,4 Histologically, most of them are squamous cell or adenoid cystic carcinomas.5 In most patients, tracheal tumors are symptomatic, but often misdiagnosed as asthma, chronic pulmonary disorder or tumors of the thyroid or lungs.4 According to Napieralska et al. clinical symptoms occur in 95% of patients. The most common symptom is dyspnea (72.4%), cough (53.4%), haemoptysis (32.8%), and hoarseness (27.6%). Other symptoms include weight loss (22.4%), pain (15.5%), dysphagia (12.1%), weakness (10.3%), stridor (5.2%), fever (8.6%), the feeling of having an obstacle in trachea (10.4%), and neck tumor (6.9%).6. Concerning the initial therapeutic approach of these patients, rigid bronchoscopy is ...
Background: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG). Methods: Cases including 66 PA (35 FNA, 31 resections), 12 BCA (5 FNA, 7 resections), 42 ACC (11 FNA, 31 resections), 1 BCAC FNA, and 10 NNSG (5 FNA, 5 resections) were obtained and stained for LEF-1. Results: On cell block (CB), 51% of PA and 60% of BCA were LEF-1 positive while 91% of ACC were LEF-1 negative. Among resections, there was a higher percentage of LEF-1 positive PA (84%) and BCA (86%), and a higher percentage of LEF-1 negative ACC (97%). LEF-1 ...
Salivary Heparanase Level Is a Potential Biomarker to Diagnose and Prognose the Malignant Salivary Gland Tumor. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - A case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carci - I noma in the sphenoid sinus. AU - Watanabe, Koichiro. AU - Toshima, Shinji. AU - Shibata, Kiyo. AU - Hosokawa, Mio. AU - Doi, Shinichiro. AU - Noda, Hiroshi. AU - Terada, Yoshiko. AU - Hara, Kazuyuki. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Purpose: To report a case of radiation retinopathy after carbon ion radiotherapy for adenoid cystic carcinoma in the sphenoid sinus. Case: A 26-year-old female was referred to us for impaired visual acuity in the right eye. She had received carbon ion radiotherapy for adenoid cystic carcinoma in the right sphenoid sinus extending to the right cavernous sinus 19 months before. The dosis of radiation totaled 57.6 GyE. Findings: Corrected visual acuity was 0.8 right and 1.2 left. The right fundus showed a few retinal hemorrhages and cotton-wool spots. Fluorescein angiography showed dry leakage from retinal vessels. Retinal nonperfusion was also present, leading ...
TY - JOUR. T1 - Histopathologic, immunophenotypic and cytogenetic features of pulmonary mucoepidermoid carcinoma. AU - Roden, Anja. AU - García, Joaquín J.. AU - Wehrs, Rebecca N.. AU - Colby, Thomas V.. AU - Khoor, Andras. AU - Leslie, Kevin O.. AU - Chen, Longwen. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Pulmonary mucoepidermoid carcinoma is an uncommon but distinctive manifestation of mucoepidermoid carcinoma. Pulmonary mucoepidermoid carcinoma occurs in adults and children and can cause diagnostic problems, especially in small biopsies. Few studies have characterized the histologic and immunophenotypic features of pulmonary mucoepidermoid carcinoma. t(11;19)(q21;p13) is considered disease-defining for mucoepidermoid carcinoma; its significance in pulmonary mucoepidermoid carcinoma warrants further study. Forty three pulmonary mucoepidermoid carcinomas were re-reviewed and graded according to the Brandwein grading system for mucoepidermoid carcinoma. Four cases were excluded because of a split ...
Conditions: Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Metastatic Parathyroid Cancer; Recurrent Adenoid Cystic Carcinoma of the Oral Cavity; Recurrent Basal Cell Carcinoma of the Lip; Recurrent Esthesioneuroblastoma of the Paranasal Sinus and Nasal Cavity; Recurrent Inverted Papilloma of the Paranasal Sinus and Nasal Cavity; Recurrent Lymphoepithelioma of the Nasopharynx; Recurrent Lymphoepithelioma of the Oropharynx; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Midline Lethal Granuloma of the Paranasal Sinus and Nasal Cavity; Recurrent Mucoepidermoid Carcinoma of the Oral Cavity; Recurrent Non-small Cell Lung Cancer; Recurrent Parathyroid Cancer; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent ...
Bronchial carcinoid tumors are very rare pulmonary neoplasms. They usually present with pulmonary symptoms or paraneoplastic syndromes. Typical (well-differentiated) tumors are usually indolent with survival exceeding 90% after resection. Atypical carcinoids have a worse prognosis. They are much more likely to recur locally or to have distant metastases. This case report describes a patient who presented with abdominal pain and hepatic lesions who was subsequently diagnosed to have bronchial carcinoid.
Question - Swelling of submandibular salivary glands. Feel bumps on gland. Reason for swelling?. Ask a Doctor about diagnosis, treatment and medication for Salivary gland cancer, Ask an ENT Specialist
Discussion: Myoepithelial carcinomas (or malignant myoepitheliomas) are rare malignant salivary gland neoplasms in which the tumor cells show myoepithelial differentiation. The entity was first described by Stromeyer et al. in 1975. The tumor was included in the WHO classification of salivary gland neoplasms as a distinct clinicopathologic entity in 1991. About 60% to 70% of myoepithelial carcinomas develop in a benign mixed tumor (carcinoma ex pleomorphic adenoma), and the remainder arise de novo. Histologically, malignant myoepitheliomas are composed of one or several cell types: spindle, plasmacytoid, epithelioid, and clear cells. Frequently, one of the cell types predominates. The neoplastic cells grow either as multiple nodules or as large solid sheets separated by variable amounts of intervening hyaline or myxoid stroma. By far, the multinodular growth pattern is more prevalent. The cytologic features generally reflect the histology. The cytologic smear can show spindle, epithelioid or ...

Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinomaUnfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma

To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we ... Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. * ... Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. ... Unfavorable clinical implications for hypermethylation of RUNX3 in patients with salivary gland adenoid cystic carcinoma. ...
more infohttps://www.spandidos-publications.com/or/26/2/349

Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from...Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from...

Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from ... Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from ... Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from ... T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/is-c-kit-cd117-immunolocalization-in-cell-block-preparations-usef

北京大学医学部机构知识库(IR@PKUHSC): Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival...北京大学医学部机构知识库([email protected]): Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival...

Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with ... Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in ... Thus, zoledronic acid should be considered a promising drug for the treatment of salivary adenoid cystic carcinoma. ... salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone ...
more infohttp://ir.bjmu.edu.cn/handle/400002259/63241

Microcystic adnexal carcinomaMicrocystic adnexal carcinoma

Condition Summary: Adenoid Cystic Carcinoma; Adnexal Carcinoma; Apocrine Carcinoma; Eccrine Porocarcinoma; Extraocular ... Signet Ring Cell Carcinoma; Skin Basal Cell Carcinoma; Skin Basosquamous Cell Carcinoma; Skin Squamous Cell Carcinoma; ... Microcystic adnexal carcinoma (MAC), desmoplastic trichoepithelioma (DTE) and morpheaform basal cell carcinoma (BCC) frequently ... Merkel Cell Carcinoma; Microcystic Adnexal Carcinoma; NK-Cell Lymphoma, Unclassifiable; Non-Melanomatous Lesion; Paget Disease ...
more infohttp://www.diseaseinfosearch.org/result/4769

Signet ring cell carcinoma - wikidocSignet ring cell carcinoma - wikidoc

Cholangiocarcinoma - Hepatocellular adenoma/Hepatocellular carcinoma - Adenoid cystic carcinoma - Familial adenomatous ... Papilloma/carcinoma (8010-8139). Small cell carcinoma - Verrucous carcinoma - Squamous cell carcinoma - Basal cell carcinoma - ... Cystic, Mucinous And Serous (8440-8499). (Mucoepidermoid carcinoma - Cystadenoma/Cystadenocarcinoma/Pseudomyxoma peritonei - ... Signet ring cell carcinoma is an epilethial malignancy characterized by the histologic appearance of signet ring cells. ...
more infohttp://es.wikidoc.org/index.php/Signet_ring_cell_carcinoma

American Urological Association - Basal Cell Carcinoma (Adenoid Cystic Carcinoma)American Urological Association - Basal Cell Carcinoma (Adenoid Cystic Carcinoma)

Adenoid cystic carcinoma consists of infiltrative nests with prominent cribriform architecture (image C) & (image D). ... Basal cell carcinoma consists of variably sized solid nests, cords, or trabeculae with peripheral palisading of cells (image A) ... Adenoid Cystic Carcinoma) Basal Cell Carcinoma (Adenoid Cystic Carcinoma). Image A. ... Urothelial Carcinoma of the Prostate * Carcinoma With Squamous Differentiation * Basal Cell Carcinoma (Adenoid Cystic Carcinoma ...
more infohttp://www.auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/prostate/other-uncommon-carcinomas/basal-cell-carcinoma-

Adenoid Cystic Carcinoma: Statistics | Cancer.NetAdenoid Cystic Carcinoma: Statistics | Cancer.Net

Adenoid Cystic Carcinoma: Statistics. Approved by the Cancer.Net Editorial Board, 09/2017 ... Sources: Adenoid Cystic Carcinoma Research Foundation and the Oral Cancer Foundation.. The next section in this guide is Risk ...
more infohttps://www.cancer.net/cancer-types/adenoid-cystic-carcinoma/statistics

Adenoid cystic carcinoma | Define Adenoid cystic carcinoma at Dictionary.comAdenoid cystic carcinoma | Define Adenoid cystic carcinoma at Dictionary.com

Adenoid cystic carcinoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. ... adenoid cystic carcinoma in Medicine Expand. adenoid cystic carcinoma n. A carcinoma characterized by large epithelial masses ...
more infohttp://www.dictionary.com/browse/adenoid-cystic-carcinoma?qsrc=2446

Adenoid Cystic Carcinoma: Risk Factors | Cancer.NetAdenoid Cystic Carcinoma: Risk Factors | Cancer.Net

Adenoid Cystic Carcinoma: Risk Factors. Approved by the Cancer.Net Editorial Board, 09/2017 ...
more infohttps://www.cancer.net/cancer-types/adenoid-cystic-carcinoma/risk-factors

Adenoid Cystic Carcinoma - The Oral Cancer FoundationAdenoid Cystic Carcinoma - The Oral Cancer Foundation

Adenoid Cystic Carcinomaadmin2018-06-05T15:08:10-08:00 What is Adenoid cystic carcinoma?. Adenoid cystic carcinoma (ACC) is an ... Fordice, J., Kershaw, C., el-Naggar, A., and Goepfert, H. (1999). Adenoid cystic carcinoma of the head and neck. Predictors of ... A wide age range has been reported for adenoid cystic carcinoma, including cases in the pediatric age group. Most individuals ... Spiers, A., Esseltine, D., Ruckdeschel, J., Davies, J., and Horton, J. (1996). Metastatic adenoid cystic carcinoma of salivary ...
more infohttps://oralcancerfoundation.org/facts/rare/adenoid-cystic-carcinoma/

Search of: Adenoid cystic carcinoma - Modify Search - ClinicalTrials.govSearch of: 'Adenoid cystic carcinoma' - Modify Search - ClinicalTrials.gov

Search of: Adenoid cystic carcinoma - Modify Search. Fill in any or all of the fields below. Click on the label to the left ...
more infohttps://clinicaltrials.gov/ct2/results/refine?cond=%22Adenoid+cystic+carcinoma%22

JCI -
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinomaJCI - Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma

BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by ... underpinnings of ACC progression and identify further targets for precision therapies.FUNDING Adenoid Cystic Carcinoma Research ...
more infohttps://www.jci.org/articles/view/128227/figure/6

JCI -
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinomaJCI - Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma

BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by ... underpinnings of ACC progression and identify further targets for precision therapies.FUNDING Adenoid Cystic Carcinoma Research ...
more infohttps://www.jci.org/articles/view/128227/pdf

Sinonasal adenoid cystic carcinoma - Sanghvi - 2013 - The Laryngoscope - Wiley Online LibrarySinonasal adenoid cystic carcinoma - Sanghvi - 2013 - The Laryngoscope - Wiley Online Library

S Ali, J C-L Yeo, T Magos, M Dickson, E Junor, Clinical outcomes of adenoid cystic carcinoma of the head and neck: a single ... Aykut A. Unsal, Sei Y. Chung, Albert H. Zhou, Soly Baredes, Jean Anderson Eloy, Sinonasal adenoid cystic carcinoma: a ... Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. ... Anniken Sandvik, Tor Audun Klingen, Sverre Langård, Sinonasal adenoid cystic carcinoma following formaldehyde exposure in the ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/lary.24085/full

Dovitinib in Adenoid Cystic Carcinoma - Full Text View - ClinicalTrials.govDovitinib in Adenoid Cystic Carcinoma - Full Text View - ClinicalTrials.gov

Carcinoma. Carcinoma, Adenoid Cystic. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... MedlinePlus related topics: Adenoids Genetic and Rare Diseases Information Center resources: Adenoid Cystic Carcinoma ... Dovitinib in Adenoid Cystic Carcinoma. The safety and scientific validity of this study is the responsibility of the study ... The purpose of this phase II study of TKI258 (Dovitinib) in adenoid cystic carcinoma is to evaluate the efficacy of TKI258 ( ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01417143?recr=Open&cond=%22Adenoids%22&rank=9

Adenoid Cystic Carcinoma & TreatmentAdenoid Cystic Carcinoma & Treatment

... how to treat adenoid cystic carcinoma, epidemiology, and related adenoid cystic carcinoma diseases. ... how to treat adenoid cystic carcinoma, epidemiology, and related adenoid cystic carcinoma diseases. ... what is the definition of adenoid cystic carcinoma, what are the signs and symptoms, medical treatment & ... what is the definition of adenoid cystic carcinoma, what are the signs and symptoms, medical treatment & ...
more infohttps://signssymptoms.org/definition-for-disease-signs-symptoms-and-treatment/?Adenoid_cystic_carcinoma-136

Stage IVC Oral Cavity Adenoid Cystic Carcinoma - DrugBankStage IVC Oral Cavity Adenoid Cystic Carcinoma - DrugBank

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
more infohttps://www.drugbank.ca/indications/DBCOND0048098

Adenoid Cystic Carcinoma
      - Cylindroma
     Summary Report | CureHunterAdenoid Cystic Carcinoma - Cylindroma Summary Report | CureHunter

Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of ... Cylindroma; Carcinoma, Adenoid Cystic; Adenocystic Carcinoma; Adenocystic Carcinomas; Adenoid Cystic Carcinomas; Carcinoma, ... Adenoid Cystic; Cylindromas; Cystic Carcinoma, Adenoid; Cystic Carcinomas, Adenoid ... Adenoid Cystic Carcinoma (Cylindroma). Subscribe to New Research on Adenoid Cystic Carcinoma ...
more infohttp://www.curehunter.com/public/keywordSummaryD003528-Adenoid-Cystic-Carcinoma-Cylindroma.do

Adenoid Cystic Carcinoma Organization International =>...Adenoid Cystic Carcinoma Organization International =>...

Adenoid Cystic Carcinoma Organization International. PO Box 936, Lake Forest, CA 92630. [email protected] Design & Development ...
more infohttp://www.accoi.org/treatments/

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.  - PubMed - NCBIMutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming. - PubMed - NCBI

Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian ... Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.. Frierson HF Jr1, ... Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming ... The neoplastic transformation of normal salivary gland (upper histologic figure) to adenoid cystic carcinoma (lower histologic ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23778135

Rare Cancer Support Forum • View forum - Adenoid Cystic CarcinomaRare Cancer Support Forum • View forum - Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma. aka: ACC, AdCC, adencyst, adenocystic, adenoidcystic, cribriform, cylindroma (incorrectly), ... Forum HOME ‹ PRIVATE: Rare Head, Neck & Oral Tumors & Cancers - Malignant, Borderline, Benign ‹ Adenoid Cystic Carcinoma ...
more infohttp://www.rare-cancer.org/forum/viewforum.php?f=76

Adenoid cystic carcinoma - WikipediaAdenoid cystic carcinoma - Wikipedia

Adenoid Cystic Carcinoma Research Foundation FAQ for patients at Adenoid Cystic Carcinoma Organization International Adenoid ... Cystic Carcinoma Information Cancer.Net: Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma at Oral Cancer Foundation [2] Search ... Adenoid cystic carcinoma (sometimes referred to as adenocyst, malignant cylindroma, adenocystic, adenoidcystic, ACC or AdCC.) ... Primary cutaneous adenoid cystic carcinoma Collagenous spherulosis Marchiò C, Weigelt B, Reis-Filho JS (Mar 2010). "Adenoid ...
more infohttps://en.wikipedia.org/wiki/Adenoid_cystic_carcinoma

Rare Cancer Support Forum • View topic - Utah Adenoid Cystic CarcinomaRare Cancer Support Forum • View topic - Utah Adenoid Cystic Carcinoma

Utah Adenoid Cystic Carcinoma. Looking for others with your cancer? Want to help others? Enter info here. ... Re: Utah Adenoid Cystic Carcinoma. by hu8tala » Sat Aug 01, 2009 4:54 pm ... Re: Utah Adenoid Cystic Carcinoma. by Tanya99 » Sun Aug 02, 2009 5:33 am ... Utah Adenoid Cystic Carcinoma. by Tanya99 » Sat Aug 01, 2009 4:16 pm ...
more infohttp://www.rare-cancer.org/forum/viewtopic.php?f=2&t=3203&p=28504

Adenoid Cystic Carcinoma Organization International => Neutron...Adenoid Cystic Carcinoma Organization International => Neutron...

Adenoid Cystic Carcinoma Organization International. PO Box 936, Lake Forest, CA 92630. [email protected] Design & Development ...
more infohttp://www.accoi.org/treatments/radiation/neutron-therapy/

Adenoid Cystic Carcinoma of the Parotid GlandAdenoid Cystic Carcinoma of the Parotid Gland

... including adenoid cystic carcinoma. Learn about other common symptoms as well as treatments for adenoid cystic carcinoma of the ... Adenoid Cystic Carcinoma. The outcome of a diagnosis of adenoid cystic carcinoma is somewhat different than that of other ... Adenoid Cystic Carcinoma of the Parotid Gland. A mimic of craniofacial pain symptoms of Ernest Syndrome and stylomandibular ... 9. Grennberg, J. Adenoid cystic carcinoma. Bobby R Alford Department of Otolaryngol Head and neck surgery, Baylor College of ...
more infohttps://www.practicalpainmanagement.com/pain/maxillofacial/adenoid-cystic-carcinoma-parotid-gland
  • T. Terada, "Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical studies," International Journal of Clinical and Experimental Pathology , vol. 5, no. 3, pp. 254-259, 2012. (hindawi.com)
  • A carcinoma characterized by large epithelial masses containing round glandlike spaces or cysts, frequently containing mucus, that are bordered by layers of epithelial cells. (dictionary.com)
  • Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. (curehunter.com)
  • They consist of a mixture of proliferative glandular tissue (an adenoid component) and stromal or basement membrane elements (a pseudoglandular or cylindromatous component). (radiopaedia.org)
  • Therefore, it is urgent to develop an efficient therapy against this carcinoma to improve patient outcome. (scielo.cl)
  • Targeted ultrasound of the palpable abnormality showed a 5 × 3 × 3 mm, hypoechoic, complicated cystic mass centered in the skin of the right breast, without abnormal vascularity. (appliedradiology.com)