A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the LUNG.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the SKIN.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
DNA present in neoplastic tissue.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the UTERINE CERVIX.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Tumors or cancer of the BRONCHI.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Elements of limited time intervals, contributing to particular results or situations.
RNA present in neoplastic tissue.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Transplantation between animals of different species.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Antibodies produced by a single clone of cells.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Tumors or cancer of the RECTUM.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Experimentally induced tumors of the LIVER.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Tumors or cancers of the ADRENAL CORTEX.
The epithelial lining of the URINARY TRACT.
Tumors or cancer of the VULVA.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Tumors or cancer of the OROPHARYNX.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Compounds that include the amino-N-phenylamide structure.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the BILE DUCTS.
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the URINARY TRACT in either the male or the female.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Established cell cultures that have the potential to propagate indefinitely.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Organic salts and esters of benzenesulfonic acid.
Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Biochemical identification of mutational changes in a nucleotide sequence.
Excision of all or part of the liver. (Dorland, 28th ed)
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Excision of kidney.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)
Tumors of cancer of the EYELIDS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Tumors or cancer of the PHARYNX.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Tumors or cancer of the HYPOPHARYNX.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Cytological diagnosis of adenoid cystic carcinoma breast--a case report. (1/324)

The cytologic features of a case of adenoid cystic carcinoma of breast diagnosed on fine needle aspiration cytology (FNAC) in a 52 years old female are described. FNAC was carried out on outer quadrant of breast. The characteristic cytological features were numerous single to branching small round to Avoid cells at places forming microacini. Numerous pink hyaline globules of variable sizes were seen along with finger like projections containing basement membrane material.  (+info)

Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study. (2/324)

OBJECTIVES: To investigate the failure patterns and the prognostic factors following postoperative radiotherapy for salivary gland carcinoma. DESIGN: Retrospective study. SETTING: University teaching hospital, Hong Kong. PATIENTS: Fifty patients who had non-disseminated salivary gland carcinoma and who received primary treatment from 1984 through 1993. MAIN OUTCOME MEASURES: Demographic data, cancer T- and N-stages, histological type, site of origin, completeness of surgery, whether postoperative radiotherapy was given, and the clinical outcome. RESULTS: Two (4%) patients had been treated with radiotherapy alone, six (12%) had undergone radical resection alone, and 42 (84%) had been radically treated by using both modalities. The 5-year overall survival and relapse-free survival rates were 78.4% and 63.1%, respectively. The free from local failure and free from distant metastasis rates at 5 years were 77.2% and 72.8%, respectively. The N-stage was a significant prognostic factor. The site of the primary tumour, T-stage, completeness of surgery, and use of postoperative radiotherapy were not significant independent prognosticators; however, among the T-stage tumours, the b-substage carcinomas had significantly fewer local failures (P=0.040) and better survival rates (P=0.038) than the a-substage carcinomas. There were seven (14%) locoregional failures without distant metastasis, seven (14%) cases of distant metastasis without locoregional failures, and four (8%) locoregional failures preceding distant metastasis; isolated regional relapse was rare (1/50; 2%). All regional failures (5/50; 10%) occurred ipsilateral to the primary lesion. There were no deaths due to lymphoepithelioma-like carcinoma or acinic cell carcinoma. CONCLUSIONS: The N-stage is the main prognostic factor of overall survival, relapse- and metastasis-free recovery, and success of treatment for salivary gland carcinoma. Optimal locoregional treatment can help reduce distant metastasis, and the maximal use of postoperative radiotherapy may contribute to improved locoregional control. Elective ipsilateral neck radiotherapy is indicated for lymphoepithelioma-like carcinoma.  (+info)

Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. (3/324)

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.  (+info)

Novel DNA copy number losses in chromosome 12q12--q13 in adenoid cystic carcinoma. (4/324)

In order to find common genetic abnormalities that may identify loci of genes involved in the development of adenoid cystic carcinoma (ACC), we investigated DNA copy number changes in 24 of these tumors by comparative genomic hybridization (CGH). Our results indicate that unlike many carcinomas, ACCs have relatively few changes in DNA copy number overall. Twenty tumors had DNA copy number changes, which were mostly restricted to a few chromosomal arms. A frequent novel finding was the loss of DNA copy number in chromosome 12q (eight tumors, 33%) with the minimal common overlapping region at 12q12--q13. Deletion in this region has not been reported to be frequent in other types of cancer analyzed by CGH. In addition, deletions in 6q23-qter and 13q21--q22 and gains of chromosome 19 were observed in 25% to 38% of ACCs. Deletion of 19q, previously reported in a small series of ACC, was not identified in the current group of carcinomas. The current CGH results for chromosomes 12 and 19 were confirmed by microsatellite allelotyping. These results indicate that DNA copy number losses in 12q may be important in the oncogenesis of ACC and suggest that the 12q12--q13 region may harbor a new tumor-suppressor gene.  (+info)

Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours. (5/324)

AIM: The gene for familial cylindromatosis (CYLD) has been localised to chromosome 16q, and has recently been cloned. Loss of heterozygosity (LOH) at 16q has also been demonstrated in sporadic cylindromas. The aim of this study was to investigate whether CYLD plays a role in the development of other skin appendage tumours. METHODS: A total of 55 cases of skin adnexal tumours, comprising 12 different types, and a control group of 14 squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs) were studied. Three microsatellites (D16S407 (16p), D16S304 (16q), and D16S308 (16q)) were analysed for LOH after microdissection from paraffin wax embedded sections using laser capture microdissection. RESULTS: In keeping with previous data, a proportion of cylindromas exhibited LOH at markers on 16q, but not at 16p. The skin adnexal tumours showing a similar pattern included apocrine hydrocystomas, eccrine spiradenomas, and sebaceous adenoma. One case of syringoma showed LOH at 16q, and a further case at 16p, but not 16q. One case of eccrine hydrocystoma showed loss at 16p, but not 16q. The remaining tumours were either negative or non-informative. All tumours in the control group were either negative or non-informative, except for a single case of BCC showing LOH at 16q. CONCLUSION: CYLD may be involved in the development of skin adnexal tumours other than cylindromas.  (+info)

Bronchial sleeve resection with complete preservation of the lung for carcinoma. (6/324)

Conservative sleeve resection with complete preservation of the lung parenchyma is very rarely applicable for the treatment of bronchial carcinomas. We used this surgical procedure in four patients with bronchial carcinoma in various sites of the central airway, and we obtained successful results. The pathological types were two squamous cell carcinomas and two low-grade malignant tumors (mucoepidermoid carcinoma and adenoid cystic carcinoma). If patients are properly selected, this operative procedure appears to be a safe and radical therapeutic option for the treatment of bronchial neoplasms arising from major bronchi.  (+info)

Radiologic-pathologic correlation of unusual lingual masses: Part II: benign and malignant tumors. (7/324)

Because the tongue is superficially located and the initial manifestation of most diseases occurring there is mucosal change, lingual lesions can be easily accessed and diagnosed without imaging analysis. Some lingual neoplasms, however, may manifest as a submucosal bulge and be located in a deep portion of the tongue, such as its base; their true characteristics and extent may be recognized only on cross-sectional images such as those obtained by CT or MRI. Some uncommon tongue neoplasms may have characteristic radiologic features, thus permitting quite specific radiologic diagnosis. Lipomas typically manifest at both CT and MR imaging as homogeneous nonenhancing lesions. Relative to subcutaneous fat they are isoattenuating on CT images, and all MR sequences show them as isointense. Due to the paramagnetic properties of melanin, metastases from melanotic melanoma usually demonstrate high signal intensity on T1-weighted MR images and low signal intensity on T2-weighted images. Although the radiologic findings for other submucosal neoplasms are nonspecific, CT and MR imaging can play an important role in the diagnostic work-up of these unusual tumors. Delineation of the extent of the tumor, and recognition and understanding of the spectrum of imaging and the pathologic features of these lesions, often help narrow the differential diagnosis.  (+info)

Defective laminin 5 processing in cylindroma cells. (8/324)

Cylindromas are benign skin tumors occurring as multiple nodules characteristically well circumscribed by an excess of basement membrane-like material. To determine the molecular defects leading to extracellular matrix accumulation, the ultrastructural, immunological, and biochemical properties of cylindroma tissue and isolated cells were analyzed. In cylindromas, hemidesmosomes are reduced in number, heterogeneous and immature compared to the normal dermal-epidermal junction. Expression of the alpha6beta4 integrin in tumor cells is weaker than in basal keratinocytes of the epidermis. Moreover, although in the epidermis alpha2beta1-integrin expression is restricted to the basal cell layer, it is found in all neoplastic cells within the nodules. Laminin 5 is present throughout the whole thickness of the basement membrane-like zone whereas laminin 10 is restricted to the interface adjacent to the tumor cells. Furthermore, laminin 5 is not properly processed and most of the alpha3A and gamma2 laminin chains remain as 165-kd and 155-kd polypeptides, respectively. Mature laminin 5 is thought to be necessary for correct hemidesmosome and basement membrane formation and its abnormal processing, as well as the low expression of alpha6beta4 integrins, could explain the lack of mature hemidesmosomes. Together, the results show that multiple molecular defects, including alteration of laminin 5 and its integrin receptors, contribute to structural aberrations of the basement membrane and associated structures in cylindromas.  (+info)

TY - JOUR. T1 - Is c-kit (CD117) immunolocalization in cell block preparations useful in the differentiation of adenoid cystic carcinoma from pleomorphic adenoma?. AU - Chandan, Vishal S.. AU - Wilbur, David. AU - Faquin, William C.. AU - Khurana, Kamal K.. PY - 2004/8/25. Y1 - 2004/8/25. N2 - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, c-kit was expressed in pleomorphic adenomas as well. Thus, c-kit was not useful in distinguishing between these two types of lesions.. AB - The authors examined the role of c-kit antigen expression in cell block material obtained by fine-needle aspiration in differentiating between adenoid cystic carcinoma and pleomorphic adenoma. It was found that c-kit expression was not restricted to adenoid cystic carcinomas; instead, ...
To elucidate the potential etiological role of RUNX3 in the development of salivary gland adenoid cystic carcinoma (ACC), we analyzed the methylation status of RUNX3 in a series of 114 ACC tissues and 3 ACC cell lines. Results showed that the methylated rate of RUNX3 was 50.9 and 3.5% in the 114 ACC samples and the corresponding normal salivary glands, respectively, achieving a significant difference ( ...
Although the histologic appearance of adenoid cystic carcinoma is low grade, management of this malignancy is a distinct therapeutic challenge because of its insidious local growth pattern, propensity for perineural involvement, tendency for distant metastasis, and pronounced ability to recur over a prolonged period.. In prospectively performed clinical trials, objective responses to any cytotoxic agent or regimen are infrequent, whereas stabilization of disease was observed more commonly.. In adenoid cystic carcinoma, the study focusing on PI3-K/AKT/mTOR pathway is rare.. According to Younes MN et als study, adenoid cystic carcinoma cell lines have increased pAkt activity when EGF-stimulation is added. And when treated with EGFR/VEGFR TK dual inhibitor, the phosphorylated form of Akt decreased despite of total level of Akt is remained unchanged.. When the investigators consider that the increased pAkt activity is one of possible predictor to mTOR inhibitor, the mTOR inhibitor might have an ...
Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC). This study aims to decipher the prognostic and mechanistic role of PIM1 in progression of SACC cells and tumor tissues. A SACC cell line (ACC-M) was transfected with shRNA plasmids targeting the PIM1 gene. The expression levels of PIM1, RUNX3 and p21 were measured by quantitative real-time PCR and western blot. Subcellular translocalization of RUNX3 and p21 proteins was assessed using immunofluorescence, and cell cycle phase was quantified using flow cytometry. A total of 97 SACC patients were retrospectively analyzed by clinicopathologic characteristics and survival outcomes. After down-regulation of PIM1 in ACC-M cells, RUNX3 and p21 proteins were translocated from cytoplasm to nucleus, with a decrease of p21 expression and increase of G0/G1 phase cells. PIM1 and RUNX3 levels show a distinct
Salivary adenoid cystic carcinoma is an epithelial tumor in the head and neck region. Despite its slow growth, patients with salivary adenoid cystic carcinoma exhibit poor long term survival because of a high rate of distant metastasis. Lung and bone are common distant metastasis sites. Zoledronic acid, a third generation bisphosphonate, has been used for tumor-induced osteolysis due to bone metastasis and has direct antitumor activity in several human neoplasms. Here, we observed that zoledronic acid inhibited salivary adenoid cystic carcinoma cell line SACC-83 xenograft tumor growth in nude mice. In vitro, zoledronic acid induced apoptosis and reduced clonogenic survival in SACC-83. Flow cytometry and western blotting indicated that the cell cycle was arrested at G0/G1. Zoledronic acid treatment upregulated reactive oxygen species as well as the autophagy marker protein LC-3B. Reactive oxygen species scavenger N-acetylcysteine and autophagy antagonist 3-methyladenine decreased zoledronic ...
Salivary adenoid cystic carcinoma (SACC) is one of the most frequent carcinomas derived from the salivary gland. Growing evidence implied the involvement of microRNAs (miRNAs) in SACC progression and metastasis. This study aimed to determine the regulatory role of miR-140-5p in SACC progression and metastasis and to explore the underlying mechanisms. MiR-140-5p and survivin mRNA expression levels were determined by quantitative real-time PCR; protein levels were evaluated by western blot assay; cell proliferation, growth, invasion, apoptosis and caspase-3 activity were evaluated by respective in vitro functional assays; xenograft nude mice model was used to assess the in vivo tumor growth; a luciferase reporter assay determined the interaction between miR-140-5p and survivin. MiR-140-5p overexpression suppressed SACC cell proliferation and invasion, induced cell apoptosis and inhibited in vivo tumor growth of SACC cells. The loss-of-function studies showed that miR-140-5p knockdown enhanced SACC cell
In a single-center phase II study reported in the Journal of Clinical Oncology, Tchekmedyian et al found that the multitargeted tyrosine kinase inhibitor lenvatinib was active in progressive recurrent or metastatic adenoid cystic carcinoma.. Study Details. In the study, 32 evaluable patients at Memorial Sloan Kettering Cancer Center with recurrent or metastatic adenoid cystic carcinoma of any primary site and radiographic or symptomatic progression were treated with lenvatinib 24 mg orally per day. Any prior therapy except lenvatinib was allowed.. The primary endpoint was overall response rate. The study was to be considered positive if 4 or more responses occurred among a total of 32 patients. Overall, 78% of patients had adenoid cystic carcinoma of either the major or minor salivary glands, and 96.9% had distant metastases.. Responses. Five patients (15.6%) had confirmed objective response (all partial responses) and an additional 24 patients (75.0%) had stable disease. Median progression-free ...
Treatment with novel radiotherapeutic technologies could increase local control in adenoid cystic carcinoma of the head and neck. Especially combined treatment with intensity-modulated radiation therapy and heavy ion (C12) boost to the primary tumor or previous tumor bed could be established as the treatment of choice in this disease.. Unfortunately, therapeutic results in the treatment of adenoid cystic carcinoma are still hampered by the occurrence of distant metastases (predominantly in the lungs) which, though progressing comparatively slowly, still limit the patients life expectancy. Most adenoid cystic carcinomas (, 80%) though, exhibit over-expression of EGFR receptors and hence provide an approach for systemic treatment. In this prospective phase II trial, the application of the EGFR antibody cetuximab will be evaluated in combination with the established treatment of intensity-modulated radiation therapy plus C12 heavy ion boost.. The trial aims at evaluation of toxicity and ...
Adenoid cystic carcinoma is a slow-growing and often fatal malignancy that can occur at multiple organ site, but is most frequently found in the salivary glands. The primary treatment is surgical removal; however, the majority of patients develop metastatic disease. In a brief report published on 17 June 2013 in theJournal of Clinical Investigation, researchers led by Andrew Futreal of the Cancer Genome Project, Wellcome Trust Sanger Institute in Cambridge, United Kingdom, reported on a whole exome sequencing performed in 24 adenoid cystic carcinoma cases.. They uncovered the involvement of multiple cancer genes that are likely to be contributing to tumour development in the context of MYB activation. The data point to disruption of chromatin regulation as a major factor in adenoid cystic carcinoma development. Furthermore, the data implicate NOTCH signalling deregulation in a proportion of cases. Finally, the analysis has identified activating mutations of the receptor tyrosine kinase FGFR2 in ...
Rare type of cancer Adenoid cystic carcinoma symptoms causes and treatment एक रिपोर्ट के मुताबिक, हर साल कैंसर के पांच लाख मामलों में करीब 1200 मामले अडेनाइड सिस्टिक कार्सिनोमा के होते हैं। Read latest hindi news (ताजा हिन्दी समाचार) on rare type of cancer, adenoid cystic carcinoma, adenoid cystic carcinoma symptoms - #1 हिन्दी न्यूज़ website.
Free Online Library: Ceruminous gland adenoid cystic carcinoma with contralateral metastasis to the brain. by Archives of Pathology & Laboratory Medicine; Health, general Cancer metastasis Diagnosis Head and neck cancer Metastasis
TY - JOUR. T1 - Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. AU - Yamamoto, Yuzo. AU - Virmani, Arvind K.. AU - Wistuba, Ignacio I.. AU - McIntire, Donald. AU - Vuitch, Frank. AU - Albores-Saavedra, Jorge. AU - Gazdar, Adi F.. PY - 1996/1/1. Y1 - 1996/1/1. N2 - Adenoid cystic carcinomas (ACC) constitute approximately 20% of malignant salivary gland tumors. Several histological types of ACC are recognized and may coexist in a single tumor. The authors divided ACC into lower grade (tubular and cribriform subtypes) and higher grade (trabecular and solid) subtypes. A preliminary analysis of 10 ACCs showed a relatively high incidence of loss of heterozygosity (LOH) at the p53 and RB genes and low or absent K-ras mutations and LOH at chromosomal loci 3p, 5q, 8p, and 9p. From 21 tumors, the authors carefully microdissected and analyzed 36 subtype foci. Three interrelated pieces of evidence indicate that the relatively poor ...
TY - JOUR. T1 - AKT3 drives adenoid cystic carcinoma development in salivary glands. AU - Zboray, Katalin. AU - Mohrherr, Julian. AU - Stiedl, Patricia. AU - Pranz, Klemens. AU - Wandruszka, Laura. AU - Grabner, Beatrice. AU - Eferl, Robert. AU - Moriggl, Richard. AU - Stoiber, Dagmar. AU - Sakamoto, Kazuhito. AU - Wagner, Kay Uwe. AU - Popper, Helmut. AU - Casanova, Emilio. AU - Moll, Herwig P.. PY - 2018/2/1. Y1 - 2018/2/1. N2 - Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Treatment of ACC patients is afflicted by high recurrence rates, the high potential of the tumors to metastasize, as well as the poor response of ACC to chemotherapy. A prerequisite for the development of targeted therapies is insightful genetic ...
Adenoid cystic carcinoma is a malignant tumour frequently described arising from seromucinous salivary tissue in the major and minor salivary glands. Within the nasal cavity, it is uncommon and usually involves the lateral wall. A rare case of adenoid cystic carcinoma of the nasal septum is presented along with a review of the literature. The presentation and management of this uncommon condition is discussed. ...
Background: Primary external auditory canal (EAC) malignancies are very rare with adenoid cystic carcinoma (ACC) representing approximately 5% of these tumors. There is insufficient knowledge of the natural behavior of ACC in EAC. The disease needs early detection and complete treatment because of its tendency to recur, vicinity to sensitive organs and lower response to radiation.. Case presentation: In this case study, we presented a case of young female (37 years old) with right external auditory canal (EAC) mass which was diagnosed as a benign tumor, a postoperative biopsy confirmed it as ACC of the EAC which is a rare case in the literature.. Conclusion: Here, we report a rare case of Adenoid Cystic Carcinoma (ACC) of External Auditory Canal (EAC) in a 37 years old Saudi female. Initial, Clinical and CT findings were suggestive of a benign cystic mass but histopathology examination confirmed that tumor was ACC of EAC. The patient underwent to radical excision of the tumor along the complete ...
Kimberly Smith admired her brother-in-law for his kindness and thoughtfulness, as well as his courageous fight with stage IV adenoid cystic carcinoma (ACC), a rare cancer, when he was only 26 and newly married. In his honor, the family established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research at MD Anderson.
Adenoid cystic carcinomas are a rare histological subtype of adenocarcinoma. Pathology Adenoid cystic carcinomas are generally considered low grade 4. The tumours have a notable tendency for perineural spread. Location They have a wide distri...
Adenoid cystic carcinoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
15. NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway SCOPUS SCIE 作者:Gao, Xiao-lei; Zheng, Min; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Li, Li; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Tang, Ya-Jie; Liang, Xin-hua; Tang, Ya-ling. 作者机构:[Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Gao, Xiao-lei; Wang, Hao-fan; Dai, Lu-ling; Yu, Xiang-hua; Yang, Xiao; Pang, Xin; Zhang, Mei; Wang, Sha-sha; Wu, Jing-biao; Liang, Xin-hua; Tang, Ya-ling] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China.; [Zheng, Min; Li, Li] Wenzhou Med Univ, Zhoushan Hosp, Dept ...
Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of hybrid carcinomas that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. AdCCs frequently harbor MYB-NFIB gene fusions. Mapping of EMCs (including hybrid forms with an AdCC component) for this fusion could help clarify the true nature of EMC as a distinct entity or simply as some variant form of AdCC. Twenty-nine cases of EMC were evaluated including 15 classic low-grade EMCs, 7 intermediate-grade EMCs, 2 EMCs with myoepithelial anaplasia, 1 EMC with high-grade transformation, and 4 hybrid EMCs with an AdCC component. Break apart ...
Objective: To summarize clinical experience on the clinical feature, etiology and treatment of patients with spontaneous bloody tears as the initial symptom. Methods: Retrospective series of case studies. The clinical data and follow-up data of 27 cases of bloody tears as the first symptom in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from June 2015 to December 2018 were reviewed. The clinical feature, specific cause, diagnosis, treatment and prognosis of these cases were evaluated. Results: A total of 27 cases were collected in this study. The patients were 10 males (37.0%) and 17 females (63.0%), including 21 adults (≥ 18 years old, 77.8%) and 6 minors (,18 years old, 22.2%). There were 22 monocular cases (81.5%) and 5 binocular cases (18.5%). Five cases (18.5%) were bleeding from the eye and other parts of the body, and 22 cases (81.5%) were bleeding only from the eye. There were 19 cases (70.4%) with hematic epiphora and secretions from the ...
Adenoid Cystic Carcinoma: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of MYB gene rearrangements and MYB-NFIB chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. MYB and TLN2 were affected by somatic mutations in two
This is among the first studies to evaluate patterns of M-SGC incidence in a U.S. population during 1992 to 2006 according to the WHO-2005 classification that presents a detailed evaluation of ,6,000 cases by age, gender, race, calendar year, and site. New information includes the observation that the highest IRs among males were observed for squamous cell carcinoma, mucoepidermoid carcinoma, and adenocarcinoma-NOS, whereas the predominant histologic subtypes among females were mucoepidermoid, acinic cell, and adenoid cystic carcinomas. Male-to-female IRRs varied markedly, with 14% to 23% lower incidence for acinic cell and adenoid cystic carcinoma and ∼5-fold higher IRR for squamous cell carcinoma. Mucoepidermoid and adenoid cystic carcinomas IRs were similar among Whites, Blacks, and Asians/Pacific Islanders, whereas most other histologic subtypes evaluated generally had higher IRs among Whites. Except for adenoid cystic carcinoma, which developed equally in the parotid and submandibular ...
PURPOSE: To study the effect of hepatitis B virus X protein binding protein (HBXIP) on proliferation, migration and invasion of adenoid cystic carcinoma cell line ACC-M, and the possible mechanism of PI3K/Akt signaling pathway. METHODS: HBXIP plasmid was transfected into ACC-M. The cells were divided into experimental group (transfected with plasmid pEGFP-N1-HBXIP) control group (non-transfected group) and blank control group (vector group, pEGFP-N1). RT-PCR was used to detect the expression HBXIP in ACC-M; MTT assay, transwell chamber experiments and scratches over the proliferation of HBXIP were utilized individually to evaluate the influence of HBXIP on ACC-M expression, migration and invasion; Western blotting was used to detect the protein expression of Akt, p-Akt, PI3K, p-PI3K and S100A4 after overexpression of HBXIP ...
Li, N., Xu, L., Zhao, H., El-Naggar, A. K. and Sturgis, E. M. (2012), A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry. Cancer, 118: 3945-3953. doi: 10.1002/cncr.26740 ...
Adenoid cystic carcinoma is a rare malignant tumor that is well known for its deceptively encouraging 5-year survival rate and its dismal survival rate at longer intervals. Controversy exists as to the benefit of regularly following asymptomatic patients to look for distant metastases because even if one is found, the options for further management are limited. When a metastasis is limited to the lung in an asymptomatic patient with no locoregional recurrence, metastasectomy might provide some long-term benefit, although we cannot know for certain. We encountered such a case, and we opted for surgical resection rather than a conservative approach. There is a need for multicenter trials so that the management of such patients, be it active or conservative, can be evidence-based.. ...
Adenoid cystic carcinoma (ACC) is a relatively rare form of cancer that most commonly develops in the salivary glands or other regions of the head and neck.
A Phase 2, Open-Label, Multi-centre Study of AL101 in Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch Mutations
The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at di …
Adenoid cystic carcinoma (ACC) of the breast is a rare subtype of breast cancer. Epidemiology They account for only 0.1-0.4% of all breast cancers. Pathology The tumour demonstrates a strikingly characteristic microscopic pattern similar to t...
目的:探讨外耳道腺样囊性癌的临床及病理特点,以提高诊断和治疗水平。方法:回顾性分析1例外耳道腺样囊性癌患者自首诊8年来连续的临床表现,病程进展,治疗及随访结果。结果:患者术后随访半年无复发。结论:外耳道腺样囊性癌生长缓慢,可长期带瘤生存但远期预后不佳,首次治疗应该采用扩大根治性手术,术后结合临床病理分期辅以放射治疗以提高治愈率。 Objective: To detect the clinical and pathological features of the adenoid cystic carcinoma of external audi-tory canal, and to improve its diagnosis and treatment level. Method: A retrospective analysis has been performed on patients with ACCEAC by their clinical manifestation, the therapy and follow-up results since 8 years ago as well as the combination with there view of related literature. Result: Patients without recurrence of postoperative follow-up of six months. Conclusion: Adenoid cystic carcinoma of external
Adenoid cystic carcinoma of nasopharynx: a single-center retrospective study, Shujun Ding, Tongai Jin, Min Xu, Yong Liang, Shoufeng Wang, Lingyun Lv, De Huai
The aim of this study was to determine the proteome of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature...
This is Cancer.Nets Guide to Adenoid Cystic Carcinoma. Use the menu below to choose the Introduction section to get started. Or, you can choose another section to learn more about a specific question you have. Each guide is reviewed by experts on the Cancer.Net Editorial Board, which is composed of medical, surgical, radiation, gynecologic, and pediatric oncologists, oncology nurses, physician assistants, social workers, and patient advocates.. ...
TY - JOUR. T1 - The mutational landscape of adenoid cystic carcinoma. AU - Ho, A.S.. AU - Kannan, K.. AU - Roy, D.M.. AU - Morris, L.G.T.. AU - Ganly, I.. AU - Katabi, N.. AU - Ramaswami, D.. AU - Walsh, L.A.. AU - Eng, S.. AU - Huse, J.T.. AU - Zhang, J.N.. AU - Dolgalev, I.. AU - Huberman, K.. AU - Heguy, A.. AU - Viale, A.. AU - Drobnjak, M.. AU - Leversha, M.A.. AU - Rice, C.E.. AU - Singh, B.. AU - Iyer, N.G.. AU - Leemans, C.R.. AU - Bloemena, E.. AU - Ferris, R.L.. AU - Seethala, R.R.. AU - Gross, B.E.. AU - Liang, Y.P.. AU - Sinha, R.. AU - Peng, L.K.. AU - Raphael, B.J.. AU - Turcan, S.. AU - Gong, Y.X.. AU - Schultz, N.. AU - Kim, S.. AU - Chiosea, S.. AU - Shah, JP. AU - Sander, C. AU - Lee, W.. AU - Chan, T.A.. PY - 2013. Y1 - 2013. U2 - 10.1038/ng.2643. DO - 10.1038/ng.2643. M3 - Article. VL - 45. SP - 791. EP - 798. JO - Nature Genetics. JF - Nature Genetics. SN - 1061-4036. IS - 7. ER - ...
Cervical lymph node metastases in salivary gland adenoid cystic carcinoma: a systematic review and meta-analysis Chunliu Ning,1 Tengfei Zhao,1 Zechen Wang,1 Delong Li,1 Yurong Kou,2 Shaohui Huang1 1Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China; 2Department of Oral Biology, School of Stomatology, China Medical University, Shenyang, Liaoning, People’s Republic of China Background: The purpose of this research was to determine whether neck dissection is necessary for the adenoid cystic carcinoma (ACC) of head and neck. Materials and methods: This article screened the abstract and full-text papers that investigated salivary gland primary ACC of head and neck. Two independent reviewers searched for articles published before October 2017 in three databases (Web of Science, PubMed, and Ovid), having no limits in date and language. Statistical data were analyzed statistically by Review Manager 5.3.
Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck This study is currently recruiting participants. Verified March 2012 by University of Iowa…
Background: Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are uncommon in the uterine cervix. .001). Conclusions: Even though the nuclei of both these buy 253863-00-2 tumor types had been oval formed, inferred through the ratio of small axis to main axis (0.728 in ACC and 0.669 in ABC), the region of nuclei was 1 approximately.7 times bigger in ACC than in ABC. Distinguishing nucleic features, including region, morphology, and chromatin design, may be useful in making the correct analysis. Keywords: Adenoid cystic carcinoma, Adenoid basal carcinoma, Genital smears, Papanicolaou check The World Wellness Firm (WHO) classifies malignant tumors from the uterine cervix into three classes: squamous tumors, glandular tumors, and additional epithelial tumors [1]. The group of additional epithelial tumors comprises five different tumor types: adenosquamous carcinoma, adenoid cystic carcinoma (ACC), adenoid basal carcinoma (ABC), neuroendocrine tumors, and undifferentiated carcinoma ...
Discover natural remedies to help in the treatment of adenoid cystic carcinoma, such as acupuncture, hydrogen peroxide therapy and Vitamin B-17.
Background:. Pim-1 (Provirus integration site for Moloney murine leukemia virus 1) belongs to the Ser/Thr kinase family and plays a pivotal role in occurrence and development of oncogenesis. Recent studies have demonstrated that Pim-1 phosphorylates RUNX3 and alters its subcellular localization. As a highly malignant tumor, salivary adenoid cystic carcinoma (ACC) accounts for approximately 10% of all epithelial salivary tumors and the 5-year survival rate of patients with highly metastatic ACC is less than 20%. However, few studies have concerned the implications of Pim-1 in the salivary ACC.. Aim:. In this study, we aimed to clarify the function of Pim-1 in ACC cell lines in vitro. Meanwhile, we measure the levels of Pim-1 and RUNX3 in the ACC tissues. The correlations between Pim-1/RUNX3 levels and clinical parameters were also analyzed. Methods:. SACC-83 and SACC-LM cells were transfected with the Pim-1 siRNA. Pim-1 mRNA and protein expression were measured using real-time PCR and immnuoblot, ...
Tumors of the lacrimal gland constitute less than 5% of all biopsied orbital lesions [3, 4]. The most common epithelial malignancy is primary adenoid cystic carcinoma; adenocarcinoma is rare, representing only 5 to 7% of epithelial tumors of the lacrimal gland [2-6]. Because there is no specific histopathologic classification for lacrimal gland tumors, they are often classified according to the histological classification of salivary gland tumors with which they share many similarities [1, 3, 7].. This subtype of lacrimal gland, adenocarcinoma, was described for the first time in 1996 by Katz et al. [2]. Since then, most reports in the literature are case reports describing an aggressive clinical pattern and poor prognosis [1, 2, 8].. The tumor usually begins in the upper eyelid as a growth and is accompanied by clinical symptoms such as lid pseudoptosis, exophthalmos, dystopia, pain, and reduced visual acuity [4, 6].. The patients short life expectancy after surgical treatment for ...
TY - JOUR. T1 - Genetic profiling of patients with adenoid cystic carcinoma of the Bartholins glands reveals potential new routes for targeted therapies. T2 - A case report. AU - Nakamura, Kohei. AU - Aimono, Eriko. AU - Tanishima, Shigeki. AU - Nomura, Hidetaka. AU - Imai, Mitsuho. AU - Hayashi, Hideyuki. AU - Nishihara, Hiroshi. N1 - Funding Information: This study was supported by JSPS KAKENHI (Grant-in-Aid for Young Scientists B) grant 20 K18232, and Japan Agency for Medical Research and Development (AMED) grant JP 16kk0205006. AMED had no control over the interpretation, writing, or publication of this work. Publisher Copyright: © 2020 The Author(s).. PY - 2020/5/28. Y1 - 2020/5/28. N2 - Background: Bartholin gland carcinomas (BGCs) are rare tumor types, for which no molecular analyses including genomic sequencing have been reported to date. Adenoid cystic carcinomas (ACCs) of the Bartholins glands are an atypical histological type of BGC, and currently nothing is known regarding their ...
Adenoid Cystic Carcinoma, Minor Salivary Gland Cancer is back/Recurred Oh No Gabbymom04 - WhatNext.com - hello, my biopsy came back and we were told the cancer is back. This doesnt seem real. Considering we started watching this in May...and I had finished Radiation in September 2018. CT and Biopsies taken this May and September. The first biopsy ..requested repeat, the sample was not good but th...
Choroidal metastasis rarely reveals a primary cancer. At this stage, they are associated with multiple metastases. Adenoid cystic carcinoma also known..
Blake , PW, Toro , JR. Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling. Hum Mutat. vol. 30. 2009. pp. 1025-36. (A comprehensive review about the clinical features, molecular genetics, and the animal models of Brooke-Spiegler syndrome.). Layegh , P, Sharifi-Sistani , N, Abadian , M, Moghiman , T. Brooke-Spiegler syndrome. Indian J Dermatol Venereol Leprol. vol. 74. 2008. pp. 632-4. (A case report describing a patient diagnosed as Brooke-Spiegler syndrome.). Kazakov , DV, Zelger , B, Rütten , A, Vazmitel , M, Spagnolo , DV, Kacerovska , D. Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol. vol. 33. 2009. pp. 705-19. (An article describing a series of 24 malignant neoplasms arising in preexisting benign spiradenoma ...
Learn about salivary gland cancer treatment advances. New radiation therapy technology has resulted in improved treatment of salivary gland cancer.
Treatments for salivary gland cancer include surgery and radiation. Learn about treatment plans and options for salivary gland cancer.
Primary malignant neoplasms of trachea and tracheal invasion by thyroid malignancies although rare are serious causes of morbidity and mortality. Management of tracheal tumours in general includes interventional endoscopy, surgery and radiotherapy. This paper describes the surgical and functional results of tracheal resections done in the surgical oncology department of a tertiary care cancer centre. Methods: This is a retrospective analysis of all patients with malignant tracheal tumours who underwent resection and anastomosis in the period 2005-2009. Nine consecutive patients with tracheal involvement either from locally invasive thyroid malignancy or from primary tracheal adenoid cystic carcinoma were included in the study. Results: Six patients had locally invasive differentiated thyroid cancer and three had adenoid cystic carcinoma. The male to female ratio was 2:1. All thyroid cases were papillary carcinoma with involvement of tracheal lumen. These patients underwent thyroidectomy along ...
TY - JOUR. T1 - Cetuximab and platinum-based chemoradio- or chemotherapy of patients with epidermal growth factor receptor expressing adenoid cystic carcinoma. T2 - A phase II trial. AU - Hitre, E.. AU - Budai, B.. AU - Takácsi-Nagy, Z.. AU - Rubovszky, G.. AU - Tóth, E.. AU - Remenár, É. AU - Polgár, C.. AU - Láng, I.. PY - 2013/9. Y1 - 2013/9. N2 - Background:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated.Methods:Eligible patients (9 with locally advanced tumour and 12 with metastases) had positive tumour EGFR expression. The cetuximab loading dose (400 mg m -2) was followed by 250 mg m -2 per week. Locally advanced tumours were irradiated (mean dose 65 Gy) and treated with concomitant cisplatin (75 mg m -2, intravenously). Patients with metastases received ...
David Height - Born in Riga, Latvia but lived in Milwaukee, WI since age of 16. Born: 1923. Diagnosed with ACC: 1957. Died from ACC: 1970. ...
Multiple familial trichoepithelioma (also known as Brooke-Spiegler syndrome and epithelioma adenoides cysticum) is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face. The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene. Types include: Brooke-Spiegler syndrome is a condition where multiple skin tumors develop from skin structures. Tumors commonly occurring in this syndrome include spiradenomas, trichoepitheliomas, and cylindromas. The tumors are generally benign, but may become malignant. Affected individuals are also at increased risk of developing tumors in tissues other than skin - particularly benign or malignant tumors of the salivary glands. Tumours in Brooke-Spiegler typically appear in early adulthood ...
ON THIS PAGE: You will find some basic information about this disease and the parts of the body it may affect. This is the first page of Cancer.Nets Guide to Salivary Gland Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide.About the salivary glandsThe salivary glands contain tissues that produce saliva. Saliva is important to the
Most people with salivary gland cancer will have radiation therapy, alone or with other treatments. Learn about radiation therapy for salivary tumours.
Layne Compston wasnt born yet when his mother was diagnosed with throat cancer as a teenager. But hes learned a lot from hearing about that experience and watching her deal with salivary gland cancer more recently.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Its extremely rare for people to be diagnosed with salivary gland cancer. Most Americans who get it are older than 55. Adam Yauch, better known as MCA of the Beastie Boys, died Friday at age 47 after having cancer for nearly three years.
Information on salivary gland cancer, including how it is diagnosed, treatments you might have, possible side effects and how to get further support.
As many readers of this blog will know, I have cancer. Ive had many operations over the last fifteen years, but a few years ago we decided that the spread was now wide enough that further surgery was not very pointful; we should instead wait for particular lesions to start causing problems, and only then treat them. (I have metastases in my lungs, liver, remaining kidney, leg, pleura and other places.). Historically, chemotherapy hasnt been an option for me. Broad spectrum chemotherapies work by killing anything growing fast; but my rather unusual cancer doesnt grow fast (which is why Ive lived as long as I have so far) and so they would kill me as quickly as they would kill it. And there are no targetted drugs for Adenoid Cystic Carcinoma, the rare salivary gland cancer I have.. However, recently my oncologist referred me to The Christie hospital in Manchester, which is doing some interesting research on cancer genetics. With them, Im trying a few things, but the most immediate is that ...
The genetic predisposition to these tumours is rare. Although cylindromas carry a significant burden of disease, they are usually not life threatening, which may explain why there are few studies looking at the benefits of genetic testing in affected or at risk individuals. Anecdotal evidence is described in one study of 26 affected patients.2 In this study, issues relating to genetic counselling which are relevant to those undergoing genetic testing for CYLD mutations are explored. When a pathogenic mutation in CYLD is identified in a patient who meets the criteria for testing, they have the advantage of knowing their diagnosis is confirmed, and can use the information for their benefit. Patients who present with multiple skin appendage tumours but are not known to have a family history may not have considered that their tumours could represent an underlying genetic cause. The knowledge that this is so can help them anticipate the fact that further tumours may develop and prepare for necessary ...
Brooke-Spiegler Syndrome. Quyn Sherrod, MD; Miguel Gutierrez, MD; Keith Carlson, MD UCLA/WLA VA Division of Dermatology David Geffen School of Medicine Los Angeles, California. History. 39 year-old, healthy, Caucasian male Multiple lesions on face and scalp beginning at 10 years old...
Examples adenoid cystic carcinoma cribriform adenocarcinoma of minor salivary glands polymorphous adenocarcinoma pleomorphic adenoma (...)
The epidemiology, pathology, clinical presentation, treatment, and prognosis of malignant primary tracheal tumors will be reviewed here.Depending upon histology and location, tracheal tumors may overlap with primary lung cancers or head and neck lesi
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
Salivary gland cancer most commonly affects the parotid glands.. The main symptom of salivary gland cancer is a lump or swelling on or near your jaw, or in your mouth or neck, although the vast majority of these lumps are non-cancerous. Other symptoms can include numbness in part of your face and drooping on one side of your face.. To read more about salivary gland cancer, visit Cancer Research UK and Macmillan Cancer Support.. ...
MeSH-minor] Adenocarcinoma / secondary. Adenocarcinoma / therapy. Adult. Aged. Aged, 80 and over. Carcinoma, Basal Cell / secondary. Carcinoma, Basal Cell / therapy. Carcinoma, Merkel Cell / secondary. Carcinoma, Merkel Cell / therapy. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / therapy. Combined Modality Therapy. Female. Follow-Up Studies. Humans. Male. Melanoma / secondary. Melanoma / therapy. Middle Aged. Neoplasm Recurrence, Local / prevention & control. Netherlands. Salivary Gland Neoplasms / secondary. Salivary Gland Neoplasms / therapy. Sarcoma / secondary. Sarcoma / therapy. Skin Neoplasms / secondary. Skin Neoplasms / therapy. Treatment Outcome. Tumor Burden / drug ...
Head and Neck Cancer is a term used to describe a number of different malignant tumours that develop in or around the throat, larynx, nose, sinuses, and mouth.. Most Head and Neck Cancers are Squamous Cell Carcinomas. This type of cancer begins in the flat, squamous cells that make up the thin layer of tissue on the surface of the structures in the head and neck. Directly beneath this lining, which is called the epithelium, some areas of the head and neck have a layer of moist tissue, called the mucosa. If a cancer is limited to the squamous layer of cells, it is called Carcinoma in Situ. If the cancer has grown beyond this cell layer and moved into the deeper tissue, then it is called Invasive Squamous Cell Carcinoma.. If a Head and Neck Cancer starts in the salivary glands, the tumour will usually be classified as an adenocarcinoma, adenoid cystic carcinoma, or mucoepidermoid carcinoma. ...
Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor
All of the tumors are infiltrative into the soft tissue, benign ceruminous glands, and/or bone. The tumor may expand into the overlying squamous surface epithelium, but it usually does not arise from the surface epithelium. The tumors are cellular, arranged in solid, cystic, cribriform, glandular, and single cell patterns. It is uncommon to see tumor necrosis, but when it is present, it is diagnostic of cancer. The same is true of perineural invasion. Nuclear pleomorphism is usually easily to identify, with the nuclei containing prominent nucleoli. There are usually increased mitotic figures, including atypical forms. There are usually areas of stromal fibrosis. Ceroid (cerumen or ear wax) is not seen in malignancies, although it is seen in benign tumors. The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types.[3]. ...
Familial Cylindromatosis (Turban Tumor Syndrome): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Neutron therapy is a form of radiotherapy used by radiation oncologists to treat certain types of tumour. Neutrons are sub-atomic particles with different radiobiological properties from photons and protons but similar to carbon ions. Neutrons are used in the treatment of salivary gland (adenoid cystic carcinomas), other head & neck tumours, sarcomas, prostate, breast cancer, mesothelioma, chordomas and rare cancers
Tumor markers are substances found in the blood, urine or body tissues that can be elevated in cancer. There are many different tumor markers. They are used in oncology to help determine the presence of cancer. An elevated level of a tumor marker can indicate cancer, however there can often also be other causes of the elevation.. Tumor markers can be produced directly by the tumor or by non-tumor cells as a response to the presence of a tumor. Tumor markers can be used in screening programs, such as screening for elevated levels of prostate specific antigen (PSA) to indicate possible prostate cancer. Tumor markers are also used to monitor patients for cancer return. Tumor markers can be classified in two groups: Cancer-specific markers and tissue-specific markers.. Adenoid Cystic Carcinoma. Ki- ...
and a 1.6-inch area in the left uterine area that needs to be checked for possible pelvic cancer.. The good news? There is no sign of disease elsewhere, including in my head, lungs, heart and other organs. Yippee! Seriously.. Life can turn on a dime, you know?. I reached for chocolate!. Did you all know Im claustrophobic? That makes all this scanning business quite stressful for me. An MRI is almost out of the question. Honestlly, part of me now believes the worst is over, if they dont make me get in another tube.. Heres the plan right now. Liver surgeon Dr. Qasim Chaudhry is sharing my report with the Tumor Board of consulting cancer physicians at Iowa Methodist, who know my internals very well by now. The discussion will probably include surgical removal of the tumors, since adenoid cystic carcinoma just doesnt have a history of responding to chemotherapy. If removal is the next step, this will be my third time having it done. First a golf-ball-sized tumor was removed from my lower ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the Cheeky Librarian, since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
This is my place to relate my experiences with cancer treatment, as well as share resources that may be helpful to fellow oral, head, and neck cancer survivors. I was diagnosed with adenoid cystic carcinoma of the left parotid on June 30, 2006. My goal is to continue enjoying the Nebraska Good Life. I call this blog the Cheeky Librarian, since the cancer was discovered in my cheek, I am a librarian, and many that know me say I fit the slang use of the word cheeky.. ...
A 51-year-old white man was admitted to the Nemazee Hospital on June 1, 1957, with the chief complaint of difficulty in breathing.He was perfectly well until si
Oranje, A.P, Halley, D.J.J, den Hollander, J.C, Teepe, R.G.J, van de Graaf, R, van den Ouweland, A.M.W, & Wagner, A. (2008). Multiple familial trichoepithelioma and familial cylindroma: One cause!. Journal of the European Academy of Dermatology and Venereology, 22(11), 1395-1396. doi:10.1111/j.1468-3083.2008.02648. ...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
Incidence and Mortality Salivary gland tumors are a morphologically and clinically diverse group of neoplasms, which may present significant diagnostic and management challenges. These tumors are rare, with an overall incidence in the Western world of approximately 2.5 cases to 3.0 cases per 100,000 per year.[1]...
View details of top pituitary gland cancer hospitals in Navi Mumbai. Get guidance from medical experts to select best pituitary gland cancer hospital in Navi Mumbai
... ceruminous adenoid cystic carcinoma (ACC), and ceruminous mucoepidermoid carcinoma. This tumor only affects the outer 1/3 to 1/ ... NOS Ceruminous adenoid cystic carcinoma Ceruminous mucoepidermoid carcinoma All of the tumors are infiltrative into the soft ... Aikawa, H.; Tomonari, K.; Okino, Y.; Hori, F.; Ueyama, T.; Suenaga, S.; Bundo, J.; Tsuji, K. (1997). "Adenoid cystic carcinoma ... The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. Pain is the most common ...
It is important that other tumors such as pleomorphic adenoma, basal cell adenoma, adenoid cystic carcinoma, and teratoma be ... Dardick, I.; Daley, T. D.; McComb, R. J. (2010). "Sialoblastoma in adults: Distinction from adenoid cystic carcinoma". Oral ...
Goldman NC (1992). "Adenoid cystic carcinoma of the external auditory canal". Otolaryngology-Head and Neck Surgery. 106 (2): ...
"Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin (BIRC5) as a prognostic marker". Histopathology. 62 (6 ... "Primary adenoid cystic carcinoma: an extremely rare eyelid tumor". Ophthalmic Plast Reconstr Surg. 28 (2): e35-6. doi:10.1097/ ... Honavar SG (2018). "Sebaceous gland carcinoma: Can we do better?". Indian J Ophthalmol. 66 (9): 1235-1237. doi:10.4103/ijo.IJO_ ... Mulay K, White VA, Shah SJ, Honavar SG (2014). "Sebaceous carcinoma: clinicopathologic features and diagnostic role of ...
Kokturk N, Demircan S, Kurul C, Turktas H (October 2004). "Tracheal adenoid cystic carcinoma masquerading asthma: a case report ...
Neutron radiotherapy for adenoid cystic carcinoma of minor salivary glands. International Journal of Radiation Oncology, ... Bull Cancer Radiother 83 (Suppl): 125-9s, 1996 See also the NCI Salivary Cancer Page Adenoid Cystic Carcinoma Neutron Radiation ... Fast neutron therapy has been applied successfully against salivary gland tumors.Adenoid cystic carcinomas have also been ... adenoid cystic carcinomas and certain types of brain tumors, especially high-grade gliomas When therapeutic energy X-rays (1 to ...
Gervase Markham, 40, British computer programmer (Mozilla), adenoid cystic carcinoma. Mateja Matejić, 94, Yugoslavian-born ...
The malignant tumors include ceruminous adenocarcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. List of ...
After many misdiagnoses, Joe was diagnosed with adenoid cystic carcinoma in 1998. At that time his illness had become terminal ...
She was diagnosed with adenoid cystic carcinoma of the salivary gland in 2013. The cancer had metastasized and while she ...
Johnny Munkhammar, 37, Swedish politician, MP (2010-2012) and writer, adenoid cystic carcinoma. Johnny Pesky, 92, American ...
March 2016). "An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma". Nature Genetics. 48 (3 ...
... ceruminous adenoid cystic carcinoma (ACC),[1][2] and ceruminous mucoepidermoid carcinoma. ... ceruminous adenoid cystic carcinoma (ACC),[1][2] ceruminous mucoepidermoid carcinoma. ... The specific features of each tumor type can help with the separation into adenoid cystic carcinoma or mucoepidermoid types.[3] ... Dong, F.; Gidley, P. W.; Ho, T.; Luna, M. A.; Ginsberg, L. E.; Sturgis, E. M. (2008). "Adenoid Cystic Carcinoma of the External ...
"Identification of differentially expressed genes in salivary adenoid cystic carcinoma cells associated with metastasis". ... GABRB2 was upregulated and hypomethylated in papillary thyroid carcinoma. The downregulation of GABRB2 enhanced the apoptotic ... GABRB2 was upregulated in adrenocortical carcinoma and salivary gland cancer, but downregulated in patients with colorectal ... 22 April 2014). "Identification of Unique miRNA Biomarkers in Colorectal Adenoma and Carcinoma Using Microarray: Evaluation of ...
Peter Tork, 77, American musician and actor (The Monkees), complications of adenoid cystic carcinoma. Lionel Upton, 94, ...
Grunewald was diagnosed with adenoid cystic carcinoma, a rare type of cancer, in 2009. Due to tumors, her salivary gland was ...
Microscopically, its histology can be confused with an adenoid cystic carcinoma and a pleomorphic adenoma. Polymorphous low- ...
Among these, the most common are the squamous-cell carcinoma and the adenoid cystic carcinoma. Ferretti GR, Bithigoffer C, ...
Anand P Reddy, Vijay; Mulay, Kaustubh (28 June 2013). "Adenoid cystic carcinoma of the lacrimal gland: role of nuclear survivin ...
Markham was a born-again Christian, and had been undergoing treatment for metastatic adenoid cystic carcinoma. He wrote about ...
Adenoid cystic carcinoma Polymorphous low-grade adenocarcinoma Epithelial-myoepithelial carcinoma Clear cell carcinoma, not ... an ancillary marker for adenoid cystic carcinoma". Mod. Pathol. 16 (12): 1224-31. doi:10.1097/01.MP.0000096046.42833.C7. PMID ... not otherwise specified Myoepithelial carcinoma Carcinoma ex pleomorphic adenoma Mammary analogue secretory carcinoma ... grade cribriform cystadenocarcinoma Mucinous adenocarcinoma Oncocytic carcinoma Salivary duct carcinoma Salivary duct carcinoma ...
1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... Lee H, Maihle NJ (1998). "Isolation and characterization of four alternate c-erbB3 transcripts expressed in ovarian carcinoma- ... 1995). "High expression of the EGFR in fibroadenomas compared to breast carcinomas". Anticancer Res. 14 (5A): 1679-88. PMID ... 1995). "Prognostic significance of ERBB3 overexpression in oral squamous cell carcinoma". Cancer Lett. 95 (1-2): 79-83. doi: ...
Adenoid cystic carcinoma is also a common malignant salivary gland lesion and has an incidence of 4-8%. This carcinoma tends to ... with the most common tumors being mucoepidermoid carcinoma and adenoid cystic carcinoma. Other malignant tumors of the parotid ... squamous cell carcinoma (arising from parenchyma of parotid gland), and undifferentiated carcinoma. Metastasis from other sites ... Mucoepidermoid carcinoma is a common malignant tumour of the salivary glands and has a low incidence of 4-13%. ...
On February 8, 2017, Conz died in Southampton, Massachusetts after a near 20 year battle with adenoid cystic carcinoma. She was ...
... lymphoma or adenoid cystic carcinoma). Tumors (e.g. glioma and meningioma of the optic nerve) within the cone formed by the ...
Only rare cancers like adenoid cystic carcinomas contains myoepithelial cells as one of the malignant component. It can be ... Epithelial-myoepithelial carcinoma (of the salivary glands) - A low-grade malignant tumor composed of both neoplastic ... If malignant, this is also known as a Myoepithelial Carcinoma. Jules J. Berman (2009). Neoplasms: principles of development and ... A usually benign or exceedingly rare malignant tumor of the breast which mimics IDC but with cells resembling adenoid cysts. ...
... adenoid cystic carcinomas, and mucoepidermoid carcinomas. Rarer still are melanomas and lymphomas of the upper aerodigestive ... Squamous cell carcinoma is most likely to appear in males over 40 years of age with a history of heavy alcohol use coupled with ... Squamous-cell carcinoma is a cancer of the squamous cell - a kind of epithelial cell found in both the skin and mucous ... Oropharyngeal squamous cell carcinomas (OSCC) begins in the oropharynx (throat), the middle part of the throat that includes ...
2006). "[Analysis of differential expression genes related to different metastasis potential of adenoid cystic carcinoma using ...
On March 3, 2009, Tork reported on his website that he had been diagnosed with adenoid cystic carcinoma, a rare, slow-growing ... his cancer experience on Facebook and encouraged his fans to support research efforts of the Adenoid Cystic Carcinoma Research ...
Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm ... The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has ... "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite having a malignant appearance ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... Oral squamous cell carcinoma (SCC)[edit]. SCC can present as erythematous or white patches, ulcers, or exophytic masses. The ... Li TJ, Cui J (August 2013). "COX-2, MMP-7 expression in oral lichen planus and oral squamous cell carcinoma". Asian Pacific ... It has also been hypothesized that it is a precursor to squamous cell carcinoma of the esophagus.[12][33] ...
M8170/3) Hepatocellular carcinoma, NOS. *(M8200/3) Adenoid cystic carcinoma. *(M8312/3) Renal cell carcinoma ... In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Cystic general. *Cystadenoma/Cystadenocarcinoma. Mucinous. *Signet ring cell carcinoma *Krukenberg tumor. *Mucinous cystadenoma ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
... lymphoma or adenoid cystic carcinoma).[10]. Tumors (e.g. glioma and meningioma of the optic nerve) within the cone formed by ...
Adenoid cystic carcinoma. *Adenoid hypertrophy. *Adenoiditis. *Adenoma sebaceum. *Adenomatoid tumor. *Adenomyoma. *Adenomyosis ...
Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
Merkel cell carcinoma. *Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma ... Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... The incidence of squamous cell carcinoma increases to 37% when the cutaneous horn is present on the penis.[3] Tenderness at the ... Malignancy is present in up to 20% of cases, with squamous cell carcinoma being the most common type. ...
Adenoid cystic carcinoma(英语:Adenoid cystic carcinoma). *Oncocytoma(英语:Oncocytoma) ... Medullary carcinoma(英语:Medullary carcinoma). *Medullary carcinoma of the breast(英语:Medullary carcinoma of the breast) ... Lobular carcinoma(英语:Lobular carcinoma). *Lobular carcinoma in situ(英语:Lobular carcinoma in situ) ... Ductal carcinoma(英语:Ductal carcinoma). *Mammary ductal carcinoma(英语:Mammary ductal carcinoma) ...
Merkel cell carcinoma. *Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma ... "Squamous cell carcinoma (epidermoid carcinoma) - skin". Atlas of Pathology (3rd ed.). Universitatii St., Iasi, Romania. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... whereas it might be inadequate for invasive nodular basal-cell carcinoma or invasive squamous-cell carcinoma.[citation needed] ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ... The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ... Malignancies in the mouth are usually carcinomas, but lymphomas, sarcomas and others may also be possible. Either the tumor ...
The black arrows point to ferrugionous bodies that are located at the periphery of a focus of non-small cell lung carcinoma, ... Adenoid hypertrophy. Peritonsillar abscess. Neck. pharynx. Pharyngitis Strep throat. Laryngopharyngeal reflux (LPR). ... Cystic fibrosis. unspecified. Bronchitis. Bronchiolitis Bronchiolitis obliterans. Diffuse panbronchiolitis. Interstitial/. ... "Asbestos content of lung tissue and carcinoma of the lung: a clinicopathologic correlation and mineral fiber analysis of 234 ...
Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma. *Intraductal papillary mucinous neoplasm ... Microscopic appearance is signet ring cell carcinoma, which is tumor cells with mucin droplet that displaces the nucleus to one ... particularly breast and lung carcinoma.[1] It is not associated with H. pylori infection or chronic gastritis. The risk factors ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hurthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
malignant epithelial tumors (Acinic cell carcinoma, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary duct carcinoma ... Epithelial-myoepithelial carcinoma, Polymorphous low-grade adenocarcinoma, Hyalinizing clear cell carcinoma) ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Malignant: Acinic cell carcinoma. *Adenocarcinoma. *Adenoid cystic carcinoma. *Carcinoma ex pleomorphic adenoma ...
Merkel cell carcinoma. *Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma ... Moy, RL (Jan 2000). "Clinical presentation of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ...
Merkel cell carcinoma. *Microcystic adnexal carcinoma. *Mucinous carcinoma. *Primary cutaneous adenoid cystic carcinoma ...
Cystic general. *Cystadenoma/Cystadenocarcinoma. Mucinous. *Signet ring cell carcinoma *Krukenberg tumor. *Mucinous cystadenoma ... Sipple JH (1961). "The association of pheochromocytoma with carcinoma of the thyroid gland". Am. J. Med. 31: 163-6. doi:10.1016 ... In 1959 Hazard et al. described medullary (solid) thyroid carcinoma. In 1961 Sipple described a combination of a ... Micrograph of a medullary thyroid carcinoma, as may be seen in MEN 2A and MEN 2B. H&E stain. ...
Adenoid cystic carcinoma. *Salivary duct carcinoma. *Epithelial-myoepithelial carcinoma. *Polymorphous low-grade adenocarcinoma ... There are cystic spaces surrounded by two uniform rows of epithelial cells with centrally placed pyknotic nuclei. The cystic ... Warthin's tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the salivary glands containing ...
Deaths from adenoid cystic carcinoma. *Johns Hopkins Bloomberg School of Public Health ...
Cystic, mucinous,. and serous. Cystic general. *Cystadenoma/Cystadenocarcinoma. Mucinous. *Signet ring cell carcinoma * ... Adrenocortical adenoma/Adrenocortical carcinoma. *Hürthle cell. Other/multiple. *Neuroendocrine tumor *Carcinoid. *Adenoid ...
Adenoid cystic carcinoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. ... adenoid cystic carcinoma in Medicine Expand. adenoid cystic carcinoma n. A carcinoma characterized by large epithelial masses ...
Statistics adapted from the Adenoid Cystic Carcinoma Research Foundation, the National Organization for Rare Disorders, and the ... Adenoid Cystic Carcinoma: Statistics. Approved by the Cancer.Net Editorial Board, 01/2021 ...
Primary cutaneous adenoid cystic carcinoma is a cutaneous condition characterized by a tumor that usually presents on the chest ... Primary cutaneous adenoid cystic carcinomas have been misinterpreted as metastatic lesions. It was characterized in 1975. ... "Primary cutaneous adenoid cystic carcinoma". J. Am. Acad. Dermatol. 58 (4): 636-41. doi:10.1016/j.jaad.2007.12.005. PMID ... Aggressive digital papillary adenocarcinoma Mucinous carcinoma Skin lesion James, William D.; Berger, Timothy G.; et al. (2006 ...
S Ali, J C-L Yeo, T Magos, M Dickson, E Junor, Clinical outcomes of adenoid cystic carcinoma of the head and neck: a single ... Aykut A. Unsal, Sei Y. Chung, Albert H. Zhou, Soly Baredes, Jean Anderson Eloy, Sinonasal adenoid cystic carcinoma: a ... Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. ... Anniken Sandvik, Tor Audun Klingen, Sverre Langård, Sinonasal adenoid cystic carcinoma following formaldehyde exposure in the ...
BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by ... underpinnings of ACC progression and identify further targets for precision therapies.FUNDING Adenoid Cystic Carcinoma Research ...
Search of: Adenoid cystic carcinoma - Modify Search. Fill in any or all of the fields below. Click on the label to the left ...
Adenoid Cystic Carcinoma: Risk Factors. Approved by the Cancer.Net Editorial Board, 09/2017 ...
Hints: Click on a [map] link to show a map of that region. Click on a [studies] link to search within your current results for studies in that region. Use the back button to return to this list and try another region. Studies with no locations are not included in the counts or on the map. Studies with multiple locations are included in each region containing locations ...
Carcinoma. Carcinoma, Adenoid Cystic. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... MedlinePlus related topics: Adenoids Genetic and Rare Diseases Information Center resources: Adenoid Cystic Carcinoma ... Dovitinib in Adenoid Cystic Carcinoma. The safety and scientific validity of this study is the responsibility of the study ... The purpose of this phase II study of TKI258 (Dovitinib) in adenoid cystic carcinoma is to evaluate the efficacy of TKI258 ( ...
Adenoid Cystic Carcinoma Organization International. November 13, 2019 by Weiden Hammer Adenoid Cystic Carcinoma Organization ... a directory of doctors who treat adenoid cystic carcinoma, and information about clinical trials. ... International provides information about adenoid cystic carcinoma, a rare head and neck cancer, to people affected by the ...
Adenoid cystic carcinoma consists of infiltrative nests with prominent cribriform architecture (image C) & (image D). ... Home Education AUAUniversity Education Products & Resources Pathology for Urologists Prostate Other Uncommon Carcinomas Basal ... Cell Carcinoma (Adenoid Cystic Carcinoma) Basal Cell Carcinoma (Adenoid Cystic Carcinoma). Image A. ... Basal cell carcinoma consists of variably sized solid nests, cords, or trabeculae with peripheral palisading of cells (image A) ...
... J Thorac Oncol. 2015 Nov;10(11):1570-5. doi: ... Introduction: A significant portion of adenoid cystic carcinoma (ACC) cases are characterized by a t(6;9)(q22-23;p23-24) ... FISH studies performed on other histologic subtypes of lung cancer (10 squamous cell carcinomas, 10 adenocarcinomas, and 10 ... small-cell carcinomas) failed to show MYB rearrangement. There was no significant difference in MYB rearrangement status with ...
This topic contains 3 study abstracts on Salivary Gland Adenoid Cystic Carcinoma. indicating that the following substances may ... 6 Abstracts with Salivary Gland Adenoid Cystic Carcinoma. Research. Filter by Study Type. Human: Case Report. ... Diseases : Cancer Metastasis, Salivary Gland Adenoid Cystic Carcinoma., Salivary Gland Diseases. Pharmacological Actions : Anti ... Diseases : Cancer Metastasis, Salivary Gland Adenoid Cystic Carcinoma., Salivary Gland Diseases. Pharmacological Actions : Anti ...
Adenoid Cystic Carcinomaadmin2018-06-05T15:08:10-08:00 What is Adenoid cystic carcinoma?. Adenoid cystic carcinoma (ACC) is an ... Fordice, J., Kershaw, C., el-Naggar, A., and Goepfert, H. (1999). Adenoid cystic carcinoma of the head and neck. Predictors of ... A wide age range has been reported for adenoid cystic carcinoma, including cases in the pediatric age group. Most individuals ... Spiers, A., Esseltine, D., Ruckdeschel, J., Davies, J., and Horton, J. (1996). Metastatic adenoid cystic carcinoma of salivary ...
What is Adenoid cystic carcinoma?. Adenoid cystic carcinoma (ACC) is an uncommon form of malignant neoplasm that arises within ... Fordice, J., Kershaw, C., el-Naggar, A., and Goepfert, H. (1999). Adenoid cystic carcinoma of the head and neck. Predictors of ... A wide age range has been reported for adenoid cystic carcinoma, including cases in the pediatric age group. Most individuals ... Spiers, A., Esseltine, D., Ruckdeschel, J., Davies, J., and Horton, J. (1996). Metastatic adenoid cystic carcinoma of salivary ...
Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian ... Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.. Frierson HF Jr1, ... Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming ... The neoplastic transformation of normal salivary gland (upper histologic figure) to adenoid cystic carcinoma (lower histologic ...
... and only ten percent of them are adenoid cystic carcinomas. Eighty percent of all tracheal tumors are malignant.... ... Adenoid Cystic Carcinoma of Distal Trachea: a Case Report. Željko Djaković orcid.org/0000-0002-7840-7519 ; Jordanovac ... "Adenoid Cystic Carcinoma of Distal Trachea: a Case Report." Acta clinica Croatica, vol. 58., br. 4., 2019, str. 777-779. https ... 2019). Adenoid Cystic Carcinoma of Distal Trachea: a Case Report, Acta clinica Croatica, 58.(4.), str. 777-779. Preuzeto s: ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Salivary adenoid cystic carcinoma (SACC) is a highly malignant carcinoma that most often arises from the secretory epithelial ... Perineural invasion in adenoid cystic carcinoma of the salivary glands: a valid prognostic indicator? Oral Oncol. 2009;45(11): ... 5. Wu HM, Ren GX, Wang LZ, Zhang CY, Chen WT, Guo W. Expression of podoplanin in salivary gland adenoid cystic carcinoma and ... Adenoid cystic salivary gland carcinoma: a histopathologic review of treatment failure patterns. Cancer. 1986;57(3):519-24. [ ...
The biologic behavior of the adenoid cystic carcinoma (ACC) and the factors predicting outcome for these tumors are still ... "Adenoid Cystic Carcinoma of the Head and Neck: Epidemiology and Predictors of Prognosis" written by Daniel Monteiro, João Lino ... A Study on 18 Cases of Parotid Adenoid Cystic Carcinoma. Practica Oto-Rhino-Laryngologica, 2017. DOI:10.5631/jibirin.110.475 ... Adenoid cystic carcinoma of head and neck. A 5-year retrospective study: Experience in a single third-level reference center ...
Tracheal adenoid cystic carcinoma that invades the tracheal prominence is a relatively rare tumor among thoracic diseases. ... Objective: To explore the epidemiology, diagnosis, treatment and future development of tracheal adenoid cystic carcinoma (TACC ... a case of tracheal adenoid cystic carcinoma with asymptomatic invasion of the tracheal prominence was reported. The clinical ... Adenoid cystic carcinoma (ACC) refers to a salivary gland neoplasm. ...
Adenocystic carcinoma. Authoritative facts from DermNet New Zealand. ... Adenoid cystic carcinoma typically arises within salivary glands. Primary cutaneous adenoid cystic carcinomaand adenoid cystic ... Histology of adenoid cystic carcinoma. In primary cutaneous adenoid cystic carcinoma, the tumour involves the dermis and may ... Special studies of adenoid cystic carcinoma. Adenoid cystic carcinoma is typically a morphologic diagnosis. The basement ...
Jessica Garcia was worried that a metastatic adenoid cystic carcinoma diagnosis would end her professional outrigger canoeing ... Jessica Garcia was worried that a metastatic adenoid cystic carcinoma diagnosis would end her professional outrigger canoeing ... An unexpected adenoid cystic carcinoma diagnosis. My cancer journey began in 2007, when I discovered a tiny bump behind my left ... My adenoid cystic carcinoma recurrence. I continued to show no evidence of disease until 2013. During a follow-up appointment, ...
Adenoid Cystic Carcinoma. aka: ACC, AdCC, adencyst, adenocystic, adenoidcystic, cribriform, cylindroma (incorrectly), ... Forum HOME ‹ PRIVATE: Rare Head, Neck & Oral Tumors & Cancers - Malignant, Borderline, Benign ‹ Adenoid Cystic Carcinoma ...
... and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The ... and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The ... Keywords: pulmonary adenoid cystic carcinoma, pulmonary mucoepidermoid carcinoma, salivary gland tumor, primary salivary gland- ... Background: Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of ...
Ceruminous gland adenoid cystic carcinoma with contralateral metastasis to the brain. by Archives of Pathology & Laboratory ... cystic+carcinoma+with+contralateral...-a082470789. *APA style: Ceruminous gland adenoid cystic carcinoma with contralateral ... carcinoma+with+contralateral...-a082470789,/a,. Citations: *MLA style: "Ceruminous gland adenoid cystic carcinoma with ... carcinoma+with+contralateral...-a082470789. *Chicago style: The Free Library. S.v. Ceruminous gland adenoid cystic carcinoma ...
by Archives of Pathology & Laboratory Medicine; Health, general Cancer Analysis Genetic aspects Carcinoma Cytogenetics DNA ... Progressive genetic alterations of adenoid cystic carcinoma with high-grade transformation. ... cystic+carcinoma+with...-a0330499522. *APA style: Progressive genetic alterations of adenoid cystic carcinoma with high-grade ... 28.) Ide F, Mishima K, Saito I. Small foci of high-grade carcinoma cells in adenoid cystic carcinoma represent an incipient ...
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of ... Carcinomas, Adenocystic; Carcinomas, Adenoid Cystic; Cylindromas; Cystic Carcinoma, Adenoid; Cystic Carcinomas, Adenoid ... Cylindroma; Carcinoma, Adenoid Cystic; Adenocystic Carcinoma; Adenocystic Carcinomas; Adenoid Cystic Carcinomas; Carcinoma, ... Adenoid Cystic Carcinoma (Cylindroma). Subscribe to New Research on Adenoid Cystic Carcinoma ...
Carcinoma. Carcinoma, Adenoid Cystic. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. ... Chidamide Combined With Cisplatin in Head and Neck Adenoid Cystic Carcinoma (HNACC). The safety and scientific validity of this ... Adenoid cystic carcinomas (ACCs) constitute of 1% of head and neck cancers. This type of tumor grows slowly with a high ... And a phase I study has showed that one of three patients with submandibular adenoid cystic carcinoma achieved a partial ...
In his honor, the family established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research at MD Anderson. ... as well as his courageous fight with stage IV adenoid cystic carcinoma (ACC), a rare cancer, when he was only 26 and newly ... The family soon established the Ryan W. Smith Endowed Fund for Adenoid Cystic Carcinoma Research to fund research and help ... Annual sporting clays tournament supports adenoid cystic carcinoma (ACC) research at MD Anderson ...
  • In the salivary glands these include benign mixed tumor, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma (PLGA). (oralcancerfoundation.org)
  • Penner CR, Folpe AL, Budnick SD (2002) C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. (springer.com)
  • It is the third most common malignant salivary gland tumor overall (after mucoepidermoid carcinoma and polymorphous low grade adenocarcinoma). (sinustumor.org)
  • ABSTRACT: Objective: To review the records of cases of Bartholin's Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. (scirp.org)
  • Aggressive digital papillary adenocarcinoma Mucinous carcinoma Skin lesion James, William D. (wikipedia.org)
  • 12,17) Histologic patterns of the transformed areas range from a cribriform high-grade adenocarcinoma to solid carcinoma with squamoid features. (thefreelibrary.com)
  • Of the malignant epithelial lacrimal tumors 20% are pleomorphic adenocarcinoma, 10% are primary adenocarcinoma, and 5% are mucoepidermoid carcinoma. (aao.org)
  • Adenoid cystic carcinomas are a rare histological subtype of adenocarcinoma. (radiopaedia.org)
  • Mass spectrometry-based proteome profile may be useful to differentiate adenoid cystic carcinoma from polymorphous adenocarcinoma of salivary glands. (bioportfolio.com)
  • Carcinoma ex-pleomorphic adenocarcinoma is an aggressive tumour that starts out as a non-cancerous mixed tumour. (cancer.ca)
  • The most common tumor type is ceruminous adenoid cystic carcinoma and ceruminous adenocarcinoma, NOS. (wikipedia.org)
  • The tumors are separated into three main histologic or microscopic types: Ceruminous adenocarcinoma, NOS Ceruminous adenoid cystic carcinoma Ceruminous mucoepidermoid carcinoma All of the tumors are infiltrative into the soft tissue, benign ceruminous glands, and/or bone. (wikipedia.org)
  • Unlike most carcinomas, most patients with ACC survive for 5 years, only to have tumors recur and progress. (oralcancerfoundation.org)
  • Primary malignant tumors of the trachea are very rare with the incidence of less than two per million people per year, and only ten percent of them are adenoid cystic carcinomas. (srce.hr)
  • Salivary adenoid cystic carcinoma (SACC) is a highly malignant carcinoma that most often arises from the secretory epithelial cells of salivary glands [ 1 ] and comprises approximately 10% of all salivary tumors [ 2 ]. (scielo.cl)
  • However, WHO classification of PSGT is non-specific and can include any tumor found in the salivary glands, cases of epithelial myoepithelial carcinoma, clear cell carcinoma, acinic tumors, mixed carcinoma, and carcinoma ex pleomorphic adenoma have been reported so far ( 4 - 9 ). (frontiersin.org)
  • The outcome of a diagnosis of adenoid cystic carcinoma is somewhat different than that of other salivary and secretory gland tumors. (practicalpainmanagement.com)
  • Of the malignant epithelial lacrimal gland tumors, about 60% are adenoid cystic carcinomas, and these most often involve the orbital lobe of the lacrimal gland. (aao.org)
  • Adenoid cystic carcinoma of the salivary gland (SACC) is a rare malignant tumors of the head and neck region, but it is one of the most common malignant tumors that are prone to perineural invasion (PNI) of the head and neck. (frontiersin.org)
  • The majority of tracheal tumors in adults are malignant and the most common ones are squamous cell carcinoma and adenoid cystic carcinoma (cylindroma). (springer.com)
  • MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. (semanticscholar.org)
  • Activating NOTCH1 point mutations were also identified in other solid tumors, including adenoid cystic carcinoma (ACC). (aacrjournals.org)
  • To assess the frequency of nodal involvement and its prognostic value in malignant tumors of the paranasal sinuses, particularly in maxillary sinus squamous cell carcinoma. (readbyqxmd.com)
  • Adenoid cystic carcinoma (ACC) is among the most lethal salivary gland tumors, with no treatments for metastatic disease that prolong survival. (aacrjournals.org)
  • Phase II trial of dasatinib for recurrent or metastatic c-KIT expressing adenoid cystic carcinoma and for nonadenoid cystic malignant salivary tumors. (uchicago.edu)
  • Adenoid cystic carcinoma (ACC) is among the most common malignant salivary gland tumors. (biomedcentral.com)
  • Staging of nasal cavity and paranasal sinus carcinomas is not as well established as for other head and neck tumors. (medscape.com)
  • Primary cutaneous adenoid cystic carcinoma is a cutaneous condition characterized by a tumor that usually presents on the chest, scalp, or vulva of middle- to older-aged persons. (wikipedia.org)
  • Primary cutaneous adenoid cystic carcinoma and adenoid cystic carcinoma of the breast are rare but well recognized. (dermnetnz.org)
  • In primary cutaneous adenoid cystic carcinoma, the tumour involves the dermis and may invade the subcutis (figure 1). (dermnetnz.org)
  • Primary cutaneous adenoid cystic carcinoma: a clinicopathologic and immunohistochemical study of 27 cases," American Journal of Surgical Pathology , vol. 37, no. 10, pp. 1603-1611, 2013. (hindawi.com)
  • J. Barnes and C. Garcia, "Primary cutaneous adenoid cystic carcinoma: a case report and review of the literature," Cutis , vol. 81, no. 3, pp. 243-246, 2008. (hindawi.com)
  • C. Cacchi, S. Persechino, L. Fidanza, and A. Bartolazzi, "A primary cutaneous adenoid-cystic carcinoma in a young woman. (hindawi.com)
  • Metastatic adenoid cystic carcinoma of salivary glands: Case reports and review of the literature, Cancer Control 3, 336-342. (oralcancerfoundation.org)
  • I've also had stereotactic radiation therapy and cryoablation, and taken immunotherapy and targeted therapy drugs to treat my metastatic adenoid cystic carcinoma, a rare type of head and neck cancer . (mdanderson.org)
  • The brain lesion was subsequently biopsied and diagnosed as metastatic adenoid cystic carcinoma. (thefreelibrary.com)
  • BUSINESS WIRE )--Ayala Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company dedicated to developing targeted cancer therapies for people living with cancer, today announced preliminary results from its ongoing Phase 2 ACCURACY study of lead investigational new drug candidate, AL101, in patients with recurrent/metastatic adenoid cystic carcinoma (ACC) with progressing disease and Notch activating mutations. (businesswire.com)
  • In a single-center phase II study reported in the Journal of Clinical Oncology , Tchekmedyian et al found that the multitargeted tyrosine kinase inhibitor lenvatinib was active in progressive recurrent or metastatic adenoid cystic carcinoma. (ascopost.com)
  • In the study, 32 evaluable patients at Memorial Sloan Kettering Cancer Center with recurrent or metastatic adenoid cystic carcinoma of any primary site and radiographic or symptomatic progression were treated with lenvatinib 24 mg orally per day. (ascopost.com)
  • The investigators concluded, "This trial met the prespecified overall response rate primary endpoint, demonstrating antitumor activity with lenvatinib in [patients with recurrent or metastatic adenoid cystic carcinoma]. (ascopost.com)
  • TARP expression was analyzed in 50 primary SACCs, 13 specimens of metastatic adenoid cystic carcinoma of salivary gland origin, and 20 noncancerous tissues around SACC via immunohistochemistry. (ovid.com)
  • Pathology revealed the adenoid cystic carcinoma of the tracheal carina. (scirp.org)
  • Unfortunately, after my surgery, pathology results showed my tumor was actually adenoid cystic carcinoma. (mdanderson.org)
  • T. Terada, "Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical studies," International Journal of Clinical and Experimental Pathology , vol. 5, no. 3, pp. 254-259, 2012. (hindawi.com)
  • Adenoid Cystic Carcinoma of the Oral Cavity: Radiology-Pathology Correlation. (uchicago.edu)
  • Cylindroma - These tumours exhibit a typical "jigsaw puzzle" architecture rather than the irregular cribriform and tubular architecture of adenoid cystic carcinoma. (dermnetnz.org)
  • Conley J, Dingman DL (1974) Adenoid cystic carcinoma in the head and neck (cylindroma). (springer.com)
  • Adenoid cystic carcinoma also known as cylindroma is very rare and constitutes 1% of major and minor salivary glands malignancies. (longdom.org)
  • Collectively, these results suggest that patients with adenoid cystic carcinoma might benefit from therapy with a BH3-mimetic small molecule. (sigmaaldrich.com)
  • analyzed the data of 507 patients with adenoid cystic carcinoma, and suggested that the positive edge is related to the worst outcome, while the negative edge and the near edge are related to the improved result, but not the distance of the tumor ( 9 ). (frontiersin.org)
  • Eighty-two patients with adenoid cystic carcinoma treated by a radical course of radiotherapy are reviewed. (openrepository.com)
  • Adenoid cystic cancer (AdCC) is a very rare type of cancer that can develop in many different body sites. (signssymptoms.org)
  • Two cell lines (ACCS and ACCY) were isolated from two individuals with adenoid cystic carcinoma (AdCC) using tissue culture techniques. (aacrjournals.org)
  • Adenoid cystic carcinoma , abbreviated AdCC , is a malignant tumour commonly seen in the salivary gland . (librepathology.org)
  • BACKGROUND: Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. (uu.nl)
  • To explore the epidemiology, diagnosis, treatment and future development of tracheal adenoid cystic carcinoma (TACC). (scirp.org)
  • This paper reports the diagnosis and management of patients with asymptomatic primary tracheal adenoid cystic carcinoma invading the augmentation process, and also elaborates the current treatment of TACC and the direction of future development. (scirp.org)
  • Adenoid cystic carcinoma is typically a morphologic diagnosis. (dermnetnz.org)
  • Kimberly Smith admired her brother-in-law, Ryan Smith, not only for his kindness and thoughtfulness ― he always put others first ― but also for how he fought his diagnosis of stage IV adenoid cystic carcinoma (ACC), a rare cancer that arises within the secretory glands. (mdanderson.org)
  • Diagnosis of adenoid cystic carcinoma generally occurs within 6 months of presenting signs and symptoms. (aao.org)
  • The patient underwent surgical resection of the tumor and the submandibular gland with a histopathological exam that confirms the diagnosis of an adenoid cystic carcinoma of the submandibular gland. (radiopaedia.org)
  • Conclusions: Bartholin's Gland Carcinoma is a rare condition with outcome dependent on duration of symptoms, including delay in diagnosis, cell-type, cellular differentiation and the International Federation of Gynecology and Obstetrics (FIGO) classification. (scirp.org)
  • Histopathological diagnosis was adenoid cystic carcinoma of the trachea. (springer.com)
  • Your doctor will give you the treatment depending on the stage of your adenoid cystic carcinoma, so the early diagnosis of this type of disease is very important, so you will get more chances of getting better. (homenaturalcures.com)
  • It is important to talk with your doctor if you suspect that you may have risk factor for adenoid cystic carcinoma, because your doctor can give you the right diagnosis. (homenaturalcures.com)
  • Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. (wiley.com)
  • BACKGROUND Adenoid cystic carcinoma (ACC) is a rare malignancy arising in salivary glands and other sites, characterized by high rates of relapse and distant spread. (jci.org)
  • Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) gene fusion that activates MYB transcriptional regulatory activity. (nih.gov)
  • Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. (nih.gov)
  • Adenoid cystic carcinoma is the second most common malignancy of the salivary glands 1 . (appliedradiology.com)
  • Adenoid cystic carcinoma (ACC) is a glandular epithelial malignancy, which frequently arises in secretary glands, especially the major and minor salivary glands. (aspetjournals.org)
  • Adenoid cystic carcinoma (ACC) is a relatively uncommon salivary gland malignancy known for its protean phenotypic features and pernicious clinical behavior. (aacrjournals.org)
  • Adenoid cystic carcinoma (ACC) is an uncommon salivary gland malignancy characterized by heterogeneous phenotypic features and persistently progressive biological behavior ( 1 - 6 ). (aacrjournals.org)
  • PURPOSE Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy that is poorly understood. (semanticscholar.org)
  • Adenoid cystic carcinoma (ACC) of the trachea and bronchus are rare primary bronchopulmonary carcinomas with low malignancy. (esmo.org)
  • Adenoid cystic carcinoma (ACC) is one of the most common malignant tumours of the salivary glands characterized by multiple recurrences and distant metastasis resulting in significantly worsening prognosis. (springer.com)
  • Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. (thno.org)
  • Acinic cell carcinoma is usually slow growing with a fairly good prognosis. (cancer.ca)
  • Genistein induced cell cycle G2/M arrest in human salivary adenoid cystic carcinoma cell line SACC-83. (greenmedinfo.com)
  • In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC). (scielo.cl)
  • Salivary Adenoid Cystic Carcinoma (SACC) is characterized by a high rate of local recurrence and infiltration, strong invasion to peripheral nerves or late distant metastasis. (plos.org)
  • This study aims to analyze the expression of T-cell receptor γ chain alternate reading frame protein (TARP) in salivary adenoid cystic carcinoma (SACC) and its distant metastases and to investigate its influences on the development and progression of SACC. (ovid.com)
  • Salivary adenoid cystic carcinoma (SACC) arises from the secretory epithelial cells of the salivary glands. (thno.org)
  • Statistics adapted from the Adenoid Cystic Carcinoma Research Foundation, the National Organization for Rare Disorders, and the Oral Cancer Foundation (sources accessed January 2021). (cancer.net)
  • Adenoid Cystic Carcinoma Organization International provides information about adenoid cystic carcinoma, a rare head and neck cancer, to people affected by the disease. (aacr.org)
  • FISH studies performed on other histologic subtypes of lung cancer (10 squamous cell carcinomas, 10 adenocarcinomas, and 10 small-cell carcinomas) failed to show MYB rearrangement. (nih.gov)
  • In one study by Ahmed and Esmaeli, a retrospective review of 53 cases of adenoid cystic carcinoma were classified according to the American Joint Committee on Cancer Classification to evaluate predictive outcomes of treatment and local recurrence. (aao.org)
  • This 61-year-old woman presented with new primary triple negative breast cancer (TNBC) in the lateral breast 10 years after completing radiation for ductal carcinoma in situ (DCIS) in the same breast.1 Despite neoadjuvant chemotherapy and mastectomy with only residual DCIS and negative nodes, patient developed a TNBC re-recurrence only 9 months later. (medworm.com)
  • MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma. (semanticscholar.org)
  • Immune checkpoint blockade, and specifically inhibition of the programmed-death-1 (PD-1) pathway, has proven clinical benefit in the treatment of melanoma, non-small cell lung cancer, and renal cell carcinoma, and preliminary studies have demonstrated efficacy in an increasing number of other tumor types ( 1-11 ). (aacrjournals.org)
  • Estrogen and progesterone receptor and p53 gene expression in adenoid cystic cancer. (ucdenver.edu)
  • One of the most common tops of glandular cancer is Cystic Adenoid Carcinoma of the Lacrimal Gland ( some refers as Lacrimal Adenoid Carcinoma ) which affects the glands in your eyes that are responsible for creating tears. (carcinomacure.com)
  • In parts of Asia, sinonasal malignancies (SNM) are the second most common head and neck cancer behind nasopharyngeal carcinoma. (medscape.com)
  • Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancer. (cancer.ca)
  • Adenoid cystic carcinoma is the 2nd most common type of salivary gland cancer. (cancer.ca)
  • Cribriform adenoid cystic carcinomas have cancer cells surrounded by normal cells. (cancer.ca)
  • In many cases, the cancer has spread to lymph nodes when salivary duct carcinoma is diagnosed. (cancer.ca)
  • Adenoid cystic carcinoma (ACC) is an uncommon form of malignant neoplasm that arises within secretory glands, most commonly the major and minor salivary glands of the head and neck. (oralcancerfoundation.org)
  • Adenoid cystic carcinoma of the head and neck. (oralcancerfoundation.org)
  • Adenoid cystic carcinomas (ACCs) constitute of 1% of head and neck cancers. (clinicaltrials.gov)
  • Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck. (radiopaedia.org)
  • Adenoid Cystic Carcinoma (ACC) is an uncommon malignant tumor, accounting for 3-5% of all neoplasms of the head and neck and approximately 22% of all salivary gland cancers [ 1 - 3 ]. (alliedacademies.org)
  • Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. (semanticscholar.org)
  • Bradley PJ (2004) Adenoid cystic carcinoma of the head and neck: a review. (springer.com)
  • Fordice J, Kershaw C, El-Naggar A, Goepfert H (1999) Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. (springer.com)
  • Should we treat lung metastases from adenoid cystic carcinoma of the head and neck in asymptomatic patients? (entjournal.com)
  • Adenoid cystic carcinoma of the head and neck: Incidence and survival trends based on 1973-2007 Surveillance, Epidemiology, and End Results data. (ucdenver.edu)
  • The adenoid cystic carcinoma is uncommon form of malignant neoplasm which arises with secretory glands and it is most commonly happening in the major and minor salivary glands of the head and neck. (homenaturalcures.com)
  • Management of adenoid cystic carcinoma of the head and neck: a single-institute study with over 25-year follow-up. (homenaturalcures.com)
  • Adenoid cystic carcinoma consists of infiltrative nests with prominent cribriform architecture (image C) & (image D) . (auanet.org)
  • 2-10) Adenoid cystic carcinoma is a biphasic tumor composed of ductal and myoepithelial components with 3 major growth patterns: tubular, cribriform, and solid. (thefreelibrary.com)
  • Primary cutaneous cribriform apocrine carcinoma: a clinicopathologic and immunohistochemical study of 26 cases of an under-recognized cutaneous adnexal neoplasm," Journal of the American Academy of Dermatology , vol. 61, no. 4, pp. 644-651, 2009. (hindawi.com)
  • Cribriform is the most common form of adenoid cystic carcinoma. (cancer.ca)
  • The pathological types encountered were: 5 cases of malignant transformation of sinonasal inverted papilloma, 2 cases of maxillary sinus carcinoma, 3 cases of ethmoid sinus carcinoma, 11 cases of mucosal melanoma, 7 cases of olfactory neuroblastoma, 2 cases of neuroendocrine carcinoma, 4 cases of myoepithelial carcinoma, 3 cases of adenoid cystic carcinoma, 1 case of malignant hemangiopericytoma. (readbyqxmd.com)
  • Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. (frontiersin.org)
  • The two major subtypes of PSGT are pulmonary adenoid cystic carcinoma (PACC) and pulmonary mucoepidermoid carcinoma (PMEC). (frontiersin.org)
  • Immunohistochemistry will help to show the biphasic appearance of the tumor, highlighting the basal or the luminal cells: Luminal cells: positive with CK7 and CD117 Basal cells: positive with p63, S100 protein and CK5/6 It is important to exclude a tumor which is directly extending into the ear canal from the parotid salivary gland, especially when dealing with an adenoid cystic or mucoepidermoid carcinoma. (wikipedia.org)
  • On its website, the organization maintains a list of international resources, information on treatment options, a directory of doctors who treat adenoid cystic carcinoma, and information about clinical trials. (aacr.org)
  • Read about adenoid cystic carcinoma medical facts: what is the definition of adenoid cystic carcinoma, what are the signs and symptoms, medical treatment & how to treat adenoid cystic carcinoma, epidemiology, and related adenoid cystic carcinoma diseases. (signssymptoms.org)
  • Djaković Ž, Janevski Z, Cesarec V, Slobodnjak Z, Stančić-Rokotov D. Adenoid Cystic Carcinoma of Distal Trachea: a Case Report. (srce.hr)
  • We present a case of a 43-year-old patient with primary adenoid cystic carcinoma of distal trachea treated by emergency bronchoscopic recanalization and resection of the tracheal tumor with end-to-end anastomosis. (srce.hr)
  • Adenoid cystic carcinoma-like pattern in spiradenoma and spiradenocylindroma: a rare feature in sporadic neoplasms and those associated with Brooke-Spiegler syndrome," The American Journal of Dermatopathology , vol. 31, no. 7, pp. 642-648, 2009. (hindawi.com)
  • To summarize the characteristics of Adenoid Cystic Carcinoma (ACC) arising from nasopharynx by analysing 28 cases in a single center, in order to enhance the care of patients with these unusual neoplasms. (alliedacademies.org)
  • A carcinoma characterized by large epithelial masses containing round glandlike spaces or cysts, frequently containing mucus, that are bordered by layers of epithelial cells. (dictionary.com)
  • Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. (curehunter.com)
  • Epithelial-myoepithelial carcinoma of the maxillary sinus: a rare case. (readbyqxmd.com)
  • Epithelial-myoepithelial carcinoma (EMC) is a rare tumor that commonly involves the salivary glands. (readbyqxmd.com)
  • Epithelial-myoepithelial carcinoma - esp. (librepathology.org)
  • Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases. (librepathology.org)
  • And a phase I study has showed that one of three patients with submandibular adenoid cystic carcinoma achieved a partial response treated with Chidamide. (clinicaltrials.gov)
  • A 65-year-old female presented to the breast care facility with a two-month history of a painful, palpable mass on the lateral aspect of her right breast, and a history of T3N0, stage III, adenoid cystic carcinoma (ACC) of the submandibular salivary gland with metastasis to the right lung. (appliedradiology.com)
  • Fig. 1: Proptosis and globe dystopia from left lacrimal gland adenoid cystic carcinoma. (aao.org)
  • Micropapillary growth pattern calcifications have been noted reminiscent of salivary duct carcinoma, although the apocrine morphology is lacking and androgen receptor and HER2/neu are typically negative by immunohistochemistry. (thefreelibrary.com)
  • Basal cell carcinoma consists of variably sized solid nests, cords, or trabeculae with peripheral palisading of cells (image A) & (image B) . (auanet.org)
  • A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma," The American Journal of Dermatopathology , vol. 8, no. 1, pp. 2-13, 1986. (hindawi.com)
  • Basal cell carcinoma (BCC). (librepathology.org)
  • A clinical, histological, and immunocytochemical comparison with adenoid cystic carcinoma of salivary glands and adenoid basal cell carcinoma. (librepathology.org)
  • Tracheal adenoid cystic carcinoma that invades the tracheal prominence is a relatively rare tumor among thoracic diseases. (scirp.org)
  • With asymptomatic invasion of the tracheal prominence, a case of tracheal adenoid cystic carcinoma with asymptomatic invasion of the tracheal prominence was reported. (scirp.org)
  • Tracheal adenoid cystic carcinoma (TACC) is a salivary gland and derived from bronchial mucosa or submucosal glands. (scirp.org)
  • At present, surgical treatment is the choice for tracheal adenoid cystic carcinoma. (scirp.org)
  • Here, a patient with tracheal adenoid cystic carcinoma who had been previously diagnosed with difficult asthma was reported. (springer.com)
  • Primary cutaneous adenoid cystic carcinomas have been misinterpreted as metastatic lesions. (wikipedia.org)
  • Although mTOR is clearly an attractive therapeutic target in tumor, no clinical study on mTOR inhibition by RAD001 has been systematically conducted in adenoid cystic carcinom. (bioportfolio.com)
  • Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition. (semanticscholar.org)
  • His management would likely have relied on pain medications, and he would have missed his window of opportunity for timely intervention for parotid adenoid cystic carcinoma. (practicalpainmanagement.com)
  • The purposes of this study are to report the first case of parotid gland adenoid cystic carcinoma metastatic to the choroid and discuss treatment approaches. (longdom.org)
  • At this time, the tumor was diagnosed as a primary adenoid cystic carcinoma of the ceruminous glands. (thefreelibrary.com)
  • Low passage primary human adenoid cystic carcinoma cells (UM-HACC-2A,-2B,-5,-6) and patient-derived xenograft (PDX) models (UM-PDX-HACC) were developed from surgical specimens obtained from 4 patients. (sigmaaldrich.com)
  • M. R. Wick and P. E. Swanson, "Primary adenoid cystic carcinoma of the skin. (hindawi.com)
  • however, its identifica-tion is not trivial.3 Here, we illustrate an in situ adenoid cystic carcinoma partially involving a mammary duct in a 68-year-old woman with primary adenoid cystic carci-noma of the right breast. (iupui.edu)
  • Lotan R, Ito H, Yasui W, Yokozaki H, Lotan D, Tahara E (1994) Expression of a 31-kDa lactoside-binding lectin in normal human gastric mucosa and in primary and metastatic gastric carcinomas. (springer.com)
  • Primary Adenoid Cystic Carcinoma (ACC) occurring in the orbital apex is rare. (alliedacademies.org)
  • Primary adenoid cystic carcinoma of the skin. (librepathology.org)
  • This aged patient exemplifies a satisfying course of adenoid cystic carcinoma under VAE resulting in good quality of life and partial tumour regression. (greenmedinfo.com)
  • Adenoid cystic carcinoma is a malignant tumour frequently described arising from seromucinous salivary tissue in the major and minor salivary glands. (gla.ac.uk)
  • Salivary duct carcinoma is a very aggressive type of tumour that can advance quickly. (cancer.ca)
  • It has a mix of different cell types, but the most common types of cells found in this tumour are sarcoma and carcinoma cells. (cancer.ca)
  • For patients treated after only a biopsy, local tumour control was achieved in 37%, demonstrating the radioresponsiveness of this type of carcinoma. (openrepository.com)
  • In other sites, ACC may be confused on histologic grounds with a variant form of squamous carcinoma known as basaloid squamous carcinoma. (oralcancerfoundation.org)
  • Adenoid cystic carcinoma (ACC) is one of the most common malignancies to arise in human salivary glands, and it also arises in the glandular tissue of other organ systems. (semanticscholar.org)
  • CpG island methylation profiling in human salivary gland adenoid cystic carcinoma. (semanticscholar.org)
  • Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. (semanticscholar.org)
  • Compare and research clinical trials and research studies related to Adenoid Cystic Carcinoma. (comparetrials.com)
  • During the past decade, a variant of ACC with areas of pleomorphic high-grade carcinoma has been recognized. (thefreelibrary.com)
  • A Bartholin's gland mass in a woman aged 40 years or more should be considered malignant until a biopsy proves otherwise.The incidence of Bartholin's Gland Carcinoma in Queensland is less than that reported elsewhere but a higher proportion of squamous cell carcinomas was found in this small series. (scirp.org)
  • Perzin KH, Gullane P, Clairmont AC (1978) Adenoid cystic carcinomas arising in salivary glands: a correlation of histologic features and clinical course. (springer.com)
  • This case illustrates an uncommon site, the Skene's glands, for adenoid cystic carcinoma in the female genitourinary tract. (elsevier.com)
  • Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with. (amegroups.com)
  • Pulmonary adenoid cystic carcinoma (ACC) is a rare type of non-small cell lung carcinoma that may develop life-threatening severe malignant airway obstruction (SMAO). (amegroups.com)
  • BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma. (sigmaaldrich.com)
  • Notably, single agent BM-1197 inhibited tumor recurrence, which is considered a major clinical challenge in the clinical management of adenoid cystic carcinoma. (sigmaaldrich.com)
  • The recurrence of adenoid cystic carcinoma is most commonly diagnosed at the metastatic stage, which means it has spread to other parts of the body. (homenaturalcures.com)
  • Of the malignancies that metastasize to the skin, carcinomas are the most common, but sarcomas, lymphomas and leukemias contribute to a large percent of skin metastases as well 3 . (appliedradiology.com)
  • Overall, 78% of patients had adenoid cystic carcinoma of either the major or minor salivary glands, and 96.9% had distant metastases. (ascopost.com)
  • Anatomic extent of lymph node metastases as an independent prognosticator in node-positive major salivary gland carcinoma: A study of the US SEER database and a Chinese multicenter cohort. (uchicago.edu)
  • Adenoid cystic carcinoma (ACC) refers to a salivary gland neoplasm. (scirp.org)
  • Tumor-induced angiogenesis is essential for invasive growth and hematogenous metastasis of adenoid cystic carcinoma (ACC), a highly aggressive neoplasm mostly occurring in salivary glands. (aspetjournals.org)