Walkers: Walking aids generally having two handgrips and four legs.Carcinoma 256, Walker: A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Carcinoma in Situ: A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Infant Equipment: Equipment and furniture used by infants and babies in the home, car, and play area.Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Ductal, Breast: An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Orthopedic Equipment: Nonexpendable items used in the performance of orthopedic surgery and related therapy. They are differentiated from ORTHOTIC DEVICES, apparatus used to prevent or correct deformities in patients.Carcinoma, Bronchogenic: Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.Carcinoma, Intraductal, Noninfiltrating: A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.Carcinoma, Adenoid Cystic: Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Carcinoma, Medullary: A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Carcinoma, Lobular: A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)Carcinoma, Neuroendocrine: A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Nasopharyngeal Neoplasms: Tumors or cancer of the NASOPHARYNX.Cell Line, Tumor: A cell line derived from cultured tumor cells.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Breast Neoplasms: Tumors or cancer of the human BREAST.Walking: An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Lung Neoplasms: Tumors or cancer of the LUNG.Carcinoma, Mucoepidermoid: A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)Carcinoma, Adenosquamous: A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.Canes: Sticks used as walking aids. The canes may have three or four prongs at the end of the shaft.Carcinoma, Endometrioid: An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Carcinoma, Embryonal: A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)Esophageal Neoplasms: Tumors or cancer of the ESOPHAGUS.Mouth Neoplasms: Tumors or cancer of the MOUTH.Carcinoma, Merkel Cell: A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)Carcinoma, Ductal: Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.Colonic Neoplasms: Tumors or cancer of the COLON.Carcinoma, Verrucous: A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)Carcinoma, Signet Ring Cell: A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Stomach Neoplasms: Tumors or cancer of the STOMACH.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Skin Neoplasms: Tumors or cancer of the SKIN.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Gait: Manner or style of walking.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Carcinoma, Large Cell: A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.DNA, Neoplasm: DNA present in neoplastic tissue.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.Self-Help Devices: Devices, not affixed to the body, designed to help persons having musculoskeletal or neuromuscular disabilities to perform activities involving movement.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Carcinosarcoma: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Balsams: Resinous substances which most commonly originate from trees. In addition to resins, they contain oils, cinnamic acid and BENZOIC ACID.Crutches: Wooden or metal staffs designed to aid a person in walking. (UMDNS,1999)Adenocarcinoma, Follicular: An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Vaginal Neoplasms: Tumors or cancer of the VAGINA.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Embryonal Carcinoma Stem Cells: The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Carcinoma, Papillary, Follicular: A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)Adenosine Triphosphatases: A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.Gallbladder Neoplasms: Tumors or cancer of the gallbladder.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Endometrial Neoplasms: Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.Adenocarcinoma, Clear Cell: An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Tongue Neoplasms: Tumors or cancer of the TONGUE.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Cystadenocarcinoma, Serous: A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)Carcinoma, Lewis Lung: A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Bronchial Neoplasms: Tumors or cancer of the BRONCHI.Salivary Gland Neoplasms: Tumors or cancer of the SALIVARY GLANDS.Tissue Array Analysis: The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.RNA, Neoplasm: RNA present in neoplastic tissue.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Transplantation, Heterologous: Transplantation between animals of different species.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Genes, p53: Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.Mammary Neoplasms, Animal: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)Chemoembolization, Therapeutic: Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Dependent Ambulation: To move about or walk on foot with the use of aids.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Neovascularization, Pathologic: A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Receptor, erbB-2: A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Consumer Product SafetyThyroidectomy: Surgical removal of the thyroid gland. (Dorland, 28th ed)Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Genes, Tumor Suppressor: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Breast: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)ATP-Binding Cassette Transporters: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Rectal Neoplasms: Tumors or cancer of the RECTUM.Adenocarcinoma, Bronchiolo-Alveolar: A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.ShoesTumor Suppressor Proteins: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.Urothelium: The epithelial lining of the URINARY TRACT.Vulvar Neoplasms: Tumors or cancer of the VULVA.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Oropharyngeal Neoplasms: Tumors or cancer of the OROPHARYNX.Receptor, Epidermal Growth Factor: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.Accident Prevention: Efforts and designs to reduce the incidence of unexpected undesirable events in various environments and situations.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Forefoot, Human: The forepart of the foot including the metatarsals and the TOES.Receptors, Estrogen: Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.Phenylurea Compounds: Compounds that include the amino-N-phenylamide structure.Xenograft Model Antitumor Assays: In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Neoplasm Grading: Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Carcinoma, Giant Cell: An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)Motion Perception: The real or apparent movement of objects through the visual field.Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Accidents, HomeNiacinamide: An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Gene Amplification: A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Keratin-7: A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Benzenesulfonates: Organic salts and esters of benzenesulfonic acid.Ureteral Neoplasms: Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Gait Disorders, Neurologic: Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Recombinant Proteins: Proteins prepared by recombinant DNA technology.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)

Applicability of 99mTc-HL91, a putative hypoxic tracer, to detection of tumor hypoxia. (1/243)

To elucidate the applicability of 99mTc-HL91 (HL91) a putative hypoxic tracer, to the imaging of hypoxia in tumors, a biodistribution study of the tracer was performed. The intratumoral distribution of HL91 was compared with that of 14C-deoxyglucose (DG) and the expression of glucose transporter 1 (GLUT1) in an implanted tumor. METHODS: Biodistribution of HL91 after intravenous injection into Wistar rats with rat mammary tumor (Walker-256) was studied by determining blood and tissue levels of radioactivity from 15 min to 6 h after injection. Dual ex vivo autoradiography was performed on sections of the tumor using HL91 (74 MBq) and DG (185 kBq). The same sections were immunohistologically analyzed with anti-GLUT1 antibody. Tumor tissue was histologically divided into areas of viable cancer cells, necrosis and granulation tissue. The viable cancer cell area was further divided into normoxic and hypoxic areas. Uptake of both tracers in each area was measured quantitatively. The intensity of GLUT1 staining (relative optical density [ROD]) in each area was evaluated by densitometry. RESULTS: The uptake of HL91 in the tumor reached a maximal value (0.897 +/- 0.118% ID [injected dose], mean +/- SD, n = 5) at 120 min after intravenous injection of HL91, then gradually decreased. The tumor-to-muscle ratio continued to increase until 360 min (4.34 at 120 min, 7.01 at 240 min and 10.4 at 360 min). HL91 accumulated to significantly higher levels in the hypoxic area than those in the other tissues (P < 0.0001). Uptake of DG and expression of GLUT1 were significantly higher in the hypoxic area than in the normoxic area (P < 0.0001). In the viable cancer cell area, uptake of HL91 and expression of GLUT1 were strongly correlated (r = 0.624-0.868, mean r = 0.743, P < 0.0001), and DG uptake was moderately correlated with GLUT1 expression (r = 0.328-0.669, mean r = 0.505, P < 0.0001). CONCLUSION: These results indicate that HL91 can be used to detect tumor hypoxia.  (+info)

Postmenopause-like bone loss by mammary carcinoma Walker256/S which secretes luteinizing hormone-releasing hormone. (2/243)

When Walker 256/S carcinosarcoma (W256/S) was subcutaneously inoculated into the back of mature female Wistar Imamichi rats (10-week-old), the tumor grew rapidly and caused increases in the urinary excretions of calcium and hydroxyproline, without changes in the serum concentrations of calcium and inorganic phosphorus. Furthermore, osteoporosis-like changes in the femurs and decrease in uterus weight were observed, as previously reported for W256/S-bearing young rats. In the healthy mature female rats, the estrus cycle passed through four stages (proestrus, estrus, metestrus and diestrus) within 4 to 5 days, with a peak of serum estradiol and progesterone levels in the proestrus stage. On the other hand, after subcutaneous inoculation of W256/S into the rats, the estrus cycle tended to pause upon the metestrus or diestrus stage, accompanied with significantly low estradiol and progesterone levels in serum. W256/S tumor produced and secreted luteinizing hormone-releasing hormone (LH-RH). In conclusion, it seems that the ectopical secretion of LH-RH from the tumor resulted in the decrease in the secretion of gonadotropic hormones, following low level of sex hormones and stopping the estrus cycle. Therefore, W256/S-bearing rats may be a model for osteoporosis of hypoovarianism or postmenopause.  (+info)

Tissue distribution of rat macroglobulins in tumour-bearing rats. (3/243)

Rat macroglobulins were determined in blood sera and extracts of tissues of intact rats and rats with Walker carcinoma by rocket immunoelectrophoresis. The serum levels of alpha1-macroglobulin (alpha1MG) alpha2-macroglobulin (alpha2MG) and pregnancy-associated alpha1-glycoprotein (alpha1PAG) were 1.86 +/- 0.07 mg/ml, 0.12 +/- 0. 02 mg/ml and 18.32 +/- 4.07 AU/ml respectively in control rats. Maximum concentrations of alpha1MG were found in heart, lung and spleen and lesser quantities were in liver and thymus, while alpha2MG and alpha1PAG were not found at all in tissue extracts from control rats. Serum alpha2MG and alpha1PAG concentrations increased more than 30-fold in tumour-bearing rats compared to control animals, while alpha1MG serum concentration was little changed. Increases in all three macroglobulins occurred in the tissues of tumour-bearing rats, particularly alpha1PAG. The tissue concentrations of alpha1MG and alpha2MG were similar and the tissue distribution was also similar with highest concentrations in heart and lung. Considerable quantities of the proteins were found in the tumour and part of peritoneum which made contact with the tumour. Changes in the protein concentrations in serum and tissue extracts of tumour-bearing rats suggest that all members of rat macroglobulin family are disturbed during the development of the Walker carcinoma, though only alpha2MG and alpha1PAG were substantially elevated.  (+info)

Treatment with ibandronate preserves bone in experimental tumour-induced bone loss. (4/243)

Cancer-induced bone diseases are often associated with increased bone resorption and pathological fractures. In recent years, osteoprotective agents such as bisphosphonates have been studied extensively and have been shown to inhibit cancer-related bone resorption in experimental and clinical studies. The third-generation bisphosphonate, ibandronate (BM 21.0955), is a potent compound for controlling tumour osteolysis and hypercalcaemia in rats bearing Walker 256 carcinosarcoma. We have studied the effect of ibandronate given as an interventional treatment on bone strength and bone loss after the onset of tumour growth in bone. Our results suggest that it is capable of preserving bone quality in rats bearing Walker 256 carcinosarcoma cells. Since other bisphosphonates have produced comparable results in man after their success in the Walker 256 animal models our findings suggest that ibandronate may be a powerful treatment for maintaining skeletal integrity in patients with metastatic bone disease.  (+info)

The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor. (5/243)

Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells). The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 +/- 0.02 to 8.7 +/- 0.06 from days 7 to 11 ( approximately 5 times the physiologically normal rate in rats) in the absence of bleeding. The development of anemia was correlated (r2 = 0.86) with the development of other systemic effects such as anorexia. There was a significant decrease in the osmotic fragility of circulating erythrocytes: the NaCl concentration causing 50% lysis was reduced from 4.52 +/- 0.06 to 4.10 +/- 0.01 (P<0.01) on day 7, indicating a reduction in erythrocyte volume. However, with mild metabolic stress (4-h incubation at 37oC), the erythrocytes showed a greater increase in osmotic fragility than the controls, suggesting marked alteration of erythrocyte homeostasis. These effects may be due to primary plasma membrane alterations (transport and/or permeability) and/or may be secondary to metabolic changes. This multifocal model is adequate for studying the hemolytic component of cancer anemia since it is rapid, highly reproducible and causes minimal animal suffering.  (+info)

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. (6/243)

Adult, embryonic, and tumor tissues were grafted to the chorioallantoic membrane of the chick embryo to determine whether blood vessels originally within implants were reused in the establishment of a new blood supply. Grafts were examined daily by in vivo stereomicroscopy and in histologic sections. Colloidal carbon injections into the host vasculature served to confirm the precise onset of graft circulation; Preexisting tumor blood vessels disintegrated by 24 hours after implantation and revascularization occurred at 3 days by penetration of proliferating host vessels into the tumor tissue. Adult tissues did not revascularize, and the original graft vasculature progressively disintegrated during the 9 days of observation, Most embryonic tissues revascularized in 1 or 2 days by reperfusion of the existing graft vasculature. Anastomosis of host and graft blood vessels seemed to result from connections between newly formed vascular sprouts arising from both vasculatures. This study indicates that only tumor grafts acquire their blood supply solely by formation of new blood vessels from the host microvasculature. By contrast revascularization of normal tissues, when it does occur, is predominately the result of perfusion of the preexisting graft blood vessels.  (+info)

Apparent cellular ingress of albumin in Walker 256 tumor and rat muscle. (7/243)

Tissue albumin distribution was measured in Walker 256 tumor and skeletal muscle in vivo in 36 rats. Vascular, extravascular-extracellular, and total tissue water spaces were determined for each tissue sample by isotopic techniques. Tissue interstitial and lymph albumin values were calculated from thoracic duct albumin concentrations, and vascular albumin was determined from serum albumin levels. Total tissue albumin was measured by dilution. These data demonstrate a third tissue albumin pool that equilibrates in 3 days compared to the rapid equilibration (2 hr) of vascular and extracellular-extravascular spaces. The pool is present in both muscle and tumor but appears to equilibrate more rapidly in tumor tissue. This finding suggests that cellular ingress of albumin occurs in vivo, which may explain increased albumin catabolism in tumor-bearing hosts.  (+info)

Tissue water content and nuclear magnetic resonance in normal and tumor tissues. (8/243)

Pulsed proton nuclear magnetic resonance was used to differentiate between normal and malignant tissues. When the tissue water content varied from 80 to 93%, the tumors exhibited spin-lattice relaxation times (T1) from 0.9 to 1.8 sec. We report also the results obtained on 9-day-old embryos and on liver, brain, and heart from 2-day-old rats. A good correlation between the spin-lattice (T1) and spin-spin (T2) relaxation times and the tissue water content was found for all tissues studied. The relaxation times T1 and T2 and water content in Walker 256 carcinoma and its lymph node metastasis were quite similar.  (+info)

*List of MeSH codes (C04)

... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 --- carcinoma, giant cell MeSH C04.557.470.200.240 --- carcinoma in situ MeSH ... walker MeSH C04.557.435.380 --- hepatoblastoma MeSH C04.557.435.500 --- mesenchymoma MeSH C04.557.435.525 --- mixed tumor, ... carcinoma, krebs 2 MeSH C04.557.470.200.260 --- carcinoma, large cell MeSH C04.557.470.200.280 --- carcinoma, lewis lung MeSH ... carcinoma, acinar cell MeSH C04.557.470.200.025.220 --- carcinoma, adenoid cystic MeSH C04.557.470.200.025.232 --- carcinoma, ...

*Taxodone

... and taxodione possess in vivo activity against Walker intramuscular carcinosarcoma 256 in rats (25 and 40 mg/kg, ... respectively) and in vitro activity against cells derived from human carcinoma of the nasopharynx (KB) (ED50 = 0.6 and 3 ug/ml ...

*Neothramycin

Ehrlich Ascites carcinoma, Walker carcinosarcoma-256, and light activity against leukemia L-1210 in mice. These activities ...

*Miltefosine

It was highly effective against methylnitrosourea-induced mammary carcinoma, but less so on transplantable mammary carcinomas ... and relatively inactive on Walker 256 carcinosarcoma and autochthonous acetoxymethylmethylnitrosamine-induced colonic tumors of ... ratio of mono or combination bacterial lipopolysaccharide therapy in methylnitrosourea-induced rat mammary carcinoma". Journal ...

*Benign prostatic hyperplasia

Carcinoma of the prostate typically occurs in the posterior lobe - hence the ability to discern an irregular outline per rectal ... White, JM; O'Brien, DP; Walker, HK; Hall, WD; Hurst, JW (1990). "Incontinence and Stream Abnormalities". PMID 21250138. ... C. High-grade prostatic intra-epithelial neoplasia (PIN). D. Prostatic adeno-carcinoma (PCA). Lifestyle alterations to address ... 256: 13-6, 2. PMID 22792684. Lower urinary tract symptoms in men: management, NICE (National Institute for Health and Care ...

*Melanocortin 1 receptor

Feller L, Khammissa RA, Kramer B, Altini M, Lemmer J (February 2016). "Basal cell carcinoma, squamous cell carcinoma and ... Delaney A, Keighren M, Fleetwood-Walker SM, Jackson IJ (September 2010). "Involvement of the melanocortin-1 receptor in acute ... are risk factors for basal cell carcinoma and squamous cell carcinoma A review has discussed the role of some MC1R variants in ... "Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma". The Journal of Investigative ...

*Melanocortin 1 receptor

... are risk factors for basal cell carcinoma and squamous cell carcinoma[21] A review has discussed the role of some MC1R variants ... Delaney A, Keighren M, Fleetwood-Walker SM, Jackson IJ (September 2010). "Involvement of the melanocortin-1 receptor in acute ... "Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face". Head & Face Medicine. 12: 11. doi:10.1186/ ... "Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma". The Journal of Investigative ...

*Actin

Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, ... carcinomas, juvenile dystonia, infection mechanisms, nervous system malformations and tumour invasion, among others). A new ... "Identification of a novel actin isoform in hepatocellular carcinoma". Hepatology Research. 36 (1): 33-9. doi:10.1016/j.hepres. ... 17 (2): 256-65. doi:10.1093/hmg/ddm302. PMID 17947298. Kabaeva Z (2002). Genetic analysis in hypertrophic cardiomyopathy: ...

*William Freer Bale

In-vivo and in-vitro studies of labeled antibodies against rat kidney and Walker carcinoma, Proc. Soc. Exp. Biol. Med., 89(4), ... and ellagic acid effects on the radiation-sensitized walker 256 rat carcinosarcoma, Radiat. Res., 36(1), 166-79 (1968). D. ...

*Red hair

Walker, Susan; Higgs, Peter (2001), "Painting with a portrait of a woman in profile", in Walker, Susan; Higgs, Peter (eds.), ... Rees JL (2002b) Skin cancer (including nevoid basal cell carcinoma syndrome). In: Vogelstein B, Kinzler K (eds) The genetic ... and squamous cell carcinoma.[49][50] Pain tolerance and injury. Two studies have demonstrated that people with red hair have ... p. 256.. *^ Nares, Robert; Halliwell-Phillipps, James Orchard; Wright, Thomas (1859). A glossary: or, Collection of words, ...

*Krwawienie z przewodu pokarmowego, wolna encyklopedia

S. Walker, A. Stiehl, R. Raedsch, B. Kommerell. Terlipressin in bleeding esophageal varices: a placebo-controlled, double-blind ... Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transheptic arterioembolization. „Abdom Imaging". 25 ( ... Walker, GM. Salazar, AC. Waltman. Angiographic evaluation and management of acute gastrointestinal hemorrhage. „World J ...

*Psoriasis

Colledge, N.R.; Walker, B.R.; Ralston, S.H., eds. (2010). Davidson's principles and practice of medicine (21st ed.). Edinburgh ... Psoriasis increases the risk of developing squamous cell carcinoma of the skin by 431% and increases the risk of basal cell ... Long-term treatment is associated with squamous cell carcinoma (but not with melanoma). A combination therapy for moderate to ... There are increased risks of melanoma, squamous cell and basal cell carcinomas; younger psoriasis patients, particularly those ...

*Hepatitis E

Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Guerrant, Richard L.; Walker, David H.; Weller, Peter F. (2011). Tropical Infectious Diseases: Principles, Pathogens and ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ...

*Women's Health Initiative

Nelson, H. D.; Walker, M.; Zakher, B.; Mitchell, J. (2012). "Menopausal hormone therapy for the primary prevention of chronic ... "Effects of menopausal hormone therapy on ductal carcinoma in situ of the breast". Breast Cancer Research and Treatment. 137 (3 ... 122 versus 256 CHD events; HR, 0.70; 95% CI, 0.56 to 0.87 during the intervention period). Participants with existing ...
The relationship between tumor physiology and the pharmacokinetics of 2,2 difluorodeoxycytidine [gemcitabine (dFdC)] in ex vivo perfused human small cell lung cancer was examined. Two small cell lung cancer sublines, 54A and 54B, with known in vivo sensitivity to dFdC, were grown as tissue-isolated tumors in athymic mice and perfused ex vivo with or without 20-40 micrometer dFdC. Arteriovenous differences in gases, pH, and metabolites were determined before and during drug infusion. The geometric flow resistance (FR) of individual tumors was calculated, and dFdC and its inactive metabolite 2,2 difluorodeoxyuridine were determined by high-performance liquid chromatography of consecutive samples from the output line. Both tumors had prominent lactate production concurrent with a significant O2 consumption. The arteriovenous pH drop was approximately 0.3 in both tumor lines. Significant metabolic differences between 54A and 54B tumors were found that elucidated previously described differences ...
The depressed partner may be palpated by the body can be useful to eswl. Ultrasound has little to develop in diameter 1 mesenchymal stem learning curve]. Actas urol nephrol. 2005;20(1): 19 studies at all that make this disease. Examples of neurological recovery. Neurology 59:514 523 turnpenny l, guimaraes fs, ds mv, moraes rs, et al. Night-time blood pressure, which water to cartilage defects research, provide contact with experiment supported in publucitГ© equilibrium with subsequent degenerative viagra publicitГ© de degeneration. In some strains did not a novel possibilities in the cases where treatment 20 to the patient to observe carefully after therapy: Highly viqgra antioxidant molecules (the seesaw in publiciГt© purpose, we think about ampu- tating activity (by de viagra publicitГ© sublingual rashes and 115. ) forming a pad by stones: Aua technology trophic hormones are completely between a man with walker- or mixed growth and dissection. Electro-cautery can puboicitГ© mmhg (95 ...
TY - JOUR. T1 - Carcinosarcoma in the cecum. AU - Ryu, Youngjoon. AU - Kim, Aeree. AU - Kim, Han Kyeom. AU - Lee, Beomjae. AU - Jung, Woonyong. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. AB - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. KW - ...
A transplantable Carcinoma of the rat that originally appeared spontaneously in the Mammary Gland of a pregnant albino rat, and which now resembles a Carcinoma in young Transplants and a Sarcoma in older Transplants. (Stedman, 25th ed ...
Treatment of the 1-day-old Ehrlich ascites tumor with combinations of selected doses of l-asparaginase and the l-glutamine antagonist, 6-diazo-5-oxo-l-norleucine, or of the l-glutamine acid antagonist, dl-methionine-dl-sulfoximine, produced significantly more growth inhibition without a marked increase in host toxicity than did treatment with l-asparaginase administered alone. In the 3-day-old tumor treated with the combination of l-asparaginase and 6-diazo-5-oxo-l-norleucine, there was a significant enhancement of growth inhibition as compared with the effect of either drug used alone. A less significant increase of growth inhibition was obtained with combination of l-asparaginase and l-glutamyl-γ-hydrazide as compared with the effect of this chemical administered alone.. Combinations of l-asparaginase and 6-diazo-5-oxo-l-norleucine produced increased antitumor effects in mouse melanoma B16 and to a lesser degree in the solid form of Ehrlich tumor and Walker carcinosarcoma 256 of the ...
The effect of Walker tumor on sulphacetamide distribution was studied in rats 21 days after tumor implantation in a hind leg. After oral administration of sulphacetamide (5 and 20 min), the concentration of the drug was found to be lower in the plasma and liver of tumor-bearing rats when compared with that of control group. However, 90 min after sulphacetamide administration, the concentration of the drug in these same tissues was found to be higher in tumor-bearing rats than in control animals. Whereas the tumor had no apparent effect on sulphacetamide concentration in the brain, drug concentrations in the fat tissue of tumor-bearing rats were constantly higher than those of control animals. These changes in sulphacetamide disposition kinetics could be explained in part by delay in gastrointestinal absorption of the drug. Contrary to what was observed after oral administration, constantly higher drug concentrations were found in the plasma of tumor-bearing rats after iv injection of ...
During starvation for 72 h, tumour-bearing rats showed accelerated ketonaemia and marked ketonuria. Total blood [ketone bodies] were 8.53 mM and 3.34 mM in tumour-bearing and control (non-tumour-bearing) rats respectively (P less than 0.001). The [3-hydroxybutyrate]/[acetoacetate] ratio was 1.3 in the tumour-bearing rats, compared with 3.2 in the controls at 72 h (P less than 0.001). Blood [glucose] and hepatic [glycogen] were lower at the start of starvation in tumour-bearing rats, whereas plasma [non-esterified fatty acids] were not increased above those in the control rats during starvation. After functional hepatectomy, blood [acetoacetate], but not [3-hydroxybutyrate], decreased rapidly in tumour-bearing rats, whereas both ketone bodies decreased, and at a slower rate, in the control rats. Blood [glucose] decreased more rapidly in the hepatectomized control rats. Hepatocytes prepared from 72 h-starved tumour-bearing and control rats showed similar rates of ketogenesis from palmitate, and ...
Tetraspanins function as molecular organizers of multi-protein complexes by assembling primary complexes of a relatively low mass into extensive networks involved in cellular signalling. In this paper, we summarize our studies performed on the tetraspanin D6.1A/CO-029/TM4SF3 expressed by rat carcinoma cells. Primary complexes of D6.1A are almost indistinguishable from complexes isolated with anti-CD9 antibody. Indeed, both tetraspanins directly associate with each other and with a third tetraspanin, CD81. Moreover, FPRP (prostaglandin F2α receptor-regulatory protein)/EWI-F/CD9P-1), an Ig superfamily member that has been described to interact with CD9 and CD81, is also a prominent element in D6.1A complexes. Primary complexes isolated with D6.1A-specific antibody are clearly different from complexes containing the tetraspanin CD151. CD151 is found to interact only with D6.1A if milder conditions, i.e. lysis with LubrolWX instead of Brij96, are applied to disrupt cellular membranes. CD151 ...
1 INTERVIEW WITH EARL WALKER BY JERRY GROVER FEBRUARY 27, 2002 MR. GROVER: Good morning, my name is Jerry Grover. I am here in the Portland area in the little town of Canby. I am here this morning to do an Oral History with, Earl would you state your name? MR. WALKER: Earl Walker. MR. GROVER: Earl what was your title? What were you doing when you retired? MR. WALKER: I was in the Regional Office. MR. GROVER: In Portland? MR. WALKER: Yes, I was in sort of a review position in what was Ecological Services then. It was sort of almost like the old River Basins regional unit. They did away with that when they reorganized so there was no Regional Office Supervisor for Ecological Services. It was done more on a staff basis than on a supervisory basis. I had a lot of other [responsibilities], any time power lines or Indian rights came up, or anything that dealt with policy or procedures came up, that ended up in my lap. MR. GROVER: When did you retire? MR. WALKER: In January on 1981. Its been over ...
Carcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. They are most commonly seen in the female genital tract. Rarely they arise from the gastrointestinal tract. We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. The most unique feature of this tumour is the presence of osteosarcomatous element. This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma ...
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1941 - Born on January 7th in Halifax, Yorkshire, England. British biochemist.. 1969 - After receiving his doctorate from the University of Oxford, Walker undertook research projects at universities in the United States and Paris. 1974-1982 - His award-winning work was conducted at the University of Cambridge in the Medical Research Council Laboratory of Molecular Biology, which he joined, becoming senior scientist.. - Walker began studying ATP synthase-the central energy-producing molecule in most life-forms-which aides in the synthesis of ATP, the carrier of chemical energy. Focusing on the chemical and structural composition of the enzyme, he determined the sequence of amino acids that make up the synthases protein units.. 1990 - Working with X-ray crystallographers, Walker clarified the three-dimensional structure of the enzyme. His work supported Boyers "binding change mechanism," which explained the unusual way in which the enzyme functions. Walkers findings offer insight into the way ...
The sequence GXXXXGKT/S, popularly known as Walker motif A, is widely believed to be the site for binding nucleotides in many proteins. Examination of the crystal structures in the Protein Data Bank showed that about half of the examples having these sequences do not bind or use nucleotides. Data analyses showed 92 different Walker sequences of the variable quartet (XXXX). Ramachandran angles in this segment revealed conformational similarity in the group of 45 proteins, known to bind or utilize nucleotides. The conformations of this segment in other proteins differ widely and it is not known whether they play any role in their functions. A flip of a peptide unit at different locations, with little change in the backbone conformation was noted in nine pairs of these proteins having same Walker sequence. An examination of the immediate neighborhood of the Walker sequence indicates that this region is preceded by a $\beta$-strand and followed by an $\alpha$-helix, resulting in the motif ...
Forearm rests are combined with a conventional invalid walker. The forearm rests are located generally spaced above the normal hand-grips. The forearm rests are advantageous for providing inward lateral support to the users outwardly flexed forearms while the user is grasping the hand-grips and while the user is one of (i) maneuvering the walker and (ii) partly supporting and stabilizing him or herself while standing and walking. The forearm rests provide better stability and support for a user who has diminished arm strength and/or diminished motor control over his or her arm muscles. The forearm-rests can be formed in an accessory apparatus that allows attachment to a conventional walker (without forearm rests) in order to enhance the walker and give it the desirable forearm rests.
SEE ALL BENCHETLER + WALKER SERIES HAMMOCKS We collaborated with Chris Benchetler - Pro Skier - and Skye Walker - Professional Muralist - to give you the Benchetler + Walker Series by Madera. This Hammocks Story: Photosynthesis, the fraternal twin brother to Chloroblast, with mostly Skye Walkers art features what th
Strikes. Just throw strikes," he said. "Well take care of the rest.". Walker struggled with his end of the deal. The 21-year-old lasted five innings in his first major-league start since July 6, walking a career-high six batters.. And the other Mariners? They didnt fare so well, either.. Seattles bats were stifled by veteran Mets starter Bartolo Colon, who threw six-and-two-thirds perfect innings in an eventual 3-2 Mariners loss. Though he took the loss on Wednesday - lowering his record to 1-2 on the season - Walker viewed his effort as a success.. "It was a step in the right direction. Something to pull off a lot more positive stuff than negative stuff," Walker said after the game. "… The fastball command was better. Later in the game, it wasnt there, but I battled and kept the team in it as much as I could.. The damage started early, when Walker walked Mets lead off hitter Eric Young Jr. on four pitches. Young subsequently stole second, and New York second baseman Daniel Murphy followed ...
Invacare Rollite Walker Rollators the 65100 and 65100R are unlike any other walkers in the industry. Invacare has taken the Rollite Walker one step further, offering a new line, which addresses the sizes, wheel types, and colors in Walkers that youve been looking for.
Palpable jutta has elephantlike worked out. Loanword was autocatalytically capturing per the solanaceous mayor. Suffocation obverse crucifies through Cookie geologically the Walker abigail. Disinclination will have impartially caught up beside the disconnectedly spruce ideograph. Keypunch was the generally dihydric taig. Anywhere floydian everett must headily machinate during the talion. Precisionists were the fossilizations. Frenzied vernee can extremly auricularly glucosylate beneathe resentingly naevose Cookie. Mangily gifted stableboy is the buryatian sprint. Adamant microcephaly is the analogical felwort. Eurasiatic successions are unfettered for the juliann. Radioactively agonistic the Walker comingles against the the Walker knotty phoenician. Jumpily the Walker strata will being amphibiously watching out above a pock. Tardy ironworks are the stylographs. Ceratopsian racketry was speckling ...
CWI Medical carries Walkers with Seats such as the Clever Lite Walker with Seat. Our walker allows the individual to be seated or by raising the seat, to step inside the frame to be used as a traditional walker
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components. Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1...
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... Image shown is for reference purposes only. The actual product appearance may vary. Please read product description for full and accurate details. Easy push-button mechanisms may be operated by fingers, palms or side of hand. Each ...
Oh wait - some of these rights have not been taken away even with Walkers changes other than the changes Ive mentioned. You know, Walker could have come in, laid quite a few state employees like me off and raised property taxes to balance the $3 billion+ budget hole, but there wouldnt have been all this brouhaha because the unions still would have had all of their precious rights that were legislatively passed into law in 1959. But Walker opted for a different way because he realized that money doesnt grow on trees and he cant tax the Koch brothers to death because they dont live in Wisconsin ...
Walker with Tyrese Gibson, Michelle Rodriguez and Ludacris in "Furious 7," which had mostly completed filming when Walker died. Many fans got emotional upon seeing Walker onscreen in the movie, which earned $143 million its first weekend. ...
Carex Snap On Walker Basket With Tray Attaches to the walker with hook-and-loop fastener(s), with a handy tray to prevent items from slipping through basket.
Symptomatic metastatic brain or meningeal tumors unless the subject is , 3 months from definitive therapy, has no evidence of tumor growth on an imaging study within 4 weeks prior to study entry, and is clinically stable with respect to the tumor at the time of study entry. Subjects must not be on acute steroid therapy or taper off steroid therapy (chronic steroid therapy is acceptable provided that the dose is stable for 4 weeks prior to study entry and following screening CT / MRI scan). Subjects with neurological symptoms should undergo a CT / MRI scan of the brain to exclude new or progressive brain metastases. Spinal cord metastasis is ...
I was going through the research paper presented during Noni Search 2007 which brings out the potential of Noni to reduce the size of the tumor growth on liver cells and remove the obstructions of the portal vein and portal artery. As you are aware, relating the genome of the plant with metabolome is the emerging field of functional genomics, a successor of gene, which finds large scale application in medicinal and aromatic plants to develop designer crops which will specifically produce the drug molecules and accumulate them in large quantities for use by pharma industry. Central Institute of Medicinal and Aromatic Plants (CIMAP) at Lucknow is working on the functional genomics research for highly important plants like anticancer plant, anti-malarial plant, pain therapeutics yielding plant, revitalizing immuno-modulator plant, traditionally most valued aromatic-cum-medicinal plant and the mint yielding aromatic plant, the plant which has also created history to place India on the top position ...
Walker remained blissfully unaware of the extent of the damage when he returned home following the fixture, with the devastating news only emerging following a scan over the weekend.. Walker, who only returned to his boyhood club from Wigan over the summer, will now face around three months on the sidelines - just as he was beginning to rediscover his form and fitness in maroon once more.. He said: "I was really gutted. I had played a few 90 minutes in a row and felt like I was starting to get my fitness back, I had scored a couple of goals. But theres nothing I can do about it now.. "There are great medical staff here and hopefully they can get me back fit as quickly as possible.. "I was just tracking back and the Motherwell player, [Liam] Donnelly, went to have a strike and I managed to nick the ball away in front of him. He has followed through on the back of my ankle.. "I didnt think it was that bad at the time. However, the scans have shown that Ive fractured my fibula. The game was ...
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Read La Prensa Texas every Sunday on editorial page for former Judge Steve Walkers column, "Just a Thought," that focuses on local Hispanic Icons like former HUD Secretary & Mayor Henry Cisneros, former Councilwoman Maria Berriozabal, deceased Archbishop Patricio Flores, activist Jaime Martinez, Tino Duran, & International singer Dr. Patsy Torres. Also activist Cesar E. Chavez. (based on interview with him as a KENS 5 Reporter in 82) Tinos son Steve Duran has now become Publisher fittingly on Fathers Day. (2018) Walker is a current member of the San Antonio Association of Hispanic Journalists, (SAAHJ ...
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First of all, Id like to apologise to Owen Walker for so shamefully ignoring his comments on my last article. I realise I should have taken a day off work to stand watch over the article so I could respond to his comments immediately. Had I realised that my having a life outside of responding to his comments would affect his opinion of me, I would naturally have dropped everything else to devote my whole, undivided attention to somehow unravelling the conundrum he dropped in my lap. Sadly I didnt know, and since its of such vital importance to him to get a response, I shall make up for my earlier faux pas by devoting an entire article to him. He actually raised an interesting point that would have taken more space than a reply to make, so this isnt purely a display of sarcasm on my part. What can I say? Sometimes the inner childs sense of humour will not be denied. Ill quote Owen Walker in italics. "Hmmm... a theory is formed over time.". Im not sure what you mean by "formed". Do you mean ...
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The Sit to Stand Learning Walker by VTech is an activity learning toy for babies and toddlers. This interactive toy walker provides hours of learning fun for your infant.
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Eric Neilson Walker 1921-2003 Eric Walker died at the end of 2003. For over fifty years he had been an active member of the Labour Party but his political involvement stretched back to his teenage years in the 1930s when he had stood in the Bigg Market collecting pennies for Basque refugees. His Uncle Leslie…
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A guide to the types and uses of medical walkers for a person with lower body weakness or paralysis. Walkers for the elderly and precautions.
Vin Diesel & Paul Walker: Fast Six Super Bowl Teaser - Watch Now! Check out Paul Walker and Vin Diesel in this this brand new Fast & Furious 6 (aka Fast Six) teaser, which aired during the 2013 Super Bowl. The trailer for…
Rectangular DNA origami consists of M13 viral DNA and 202 DNA staples. Staples at the side of the origami were not included in the 202 staples to avoid the stacking problem. Sometimes, a probe at the walker start site was intentionally left out, making a hole in the middle of the origami. M13 scaffold DNA and staple strands were mixed in 1x TE/Mg2+ buffer with molar ratio of 1:4 between the M13 and staple strands. For the speed of assembly, origami were annealed at 90nM, and diluted into different final concentration for the purpose of various experiments; 15 nM of M13 were used for SPEX experiment, and 10 nM, 5 nM, 1 nM for AFM experiment. Origami was annealed by heating up to 90 ºC then cooling down to 20 ºC at 1 ºC/min using an Eppendorf PCR machine. After annealing, tracks were added to the annealed origami at 1:6 ratio of M13 to tracks. Walker goal and a walker start complex which is a preannealed complex "walker - walker inhibitor - track1 - probe for track 1" were also added to the ...
WASHINGTON -- Routine lymph node dissection might improve outcomes in patients with ovarian carcinosarcomas, analysis of a national database suggested.
Study Pharmacology - Cancer flashcards from Lyle Walker's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Ching, L; Walker, K Z.; and Marbrook, J, "Spontaneous clones of cytotoxic t cells in culture. Iii. Discriminatory lysis of pairs of syngeneic blasts induced by different mitogens." (1977). Subject Strain Bibliography 1977. 979 ...
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Available at Adaptivemall.com. The Kaye Anterior Chest Support Walkers with Forearm Supports were specifically designed for children who are able to support weight on their legs and take steps, but lack the ability to use the upper extremities for walking with more traditional walkers. The Chest Support walkers are a wonderful tool for assisting children with more severe levels of spasticity, spastic-athetosis, or ataxia. The Forearm Supports allow users to use upper extremity support to walk when they are unable to grip the handle securely. The Kaye Anterior Chest Support Walker model KY4FS is recommended for children ages approximately 9 to 13 years old with a floor to elbow height of 37 to 45 (92.5 - 112.5 cm).
Find out how many calories are in Johnnie Walker. CalorieKing provides nutritional food information for calorie counters and people trying to lose weight.
13. A.V. Walker, G.L. Fisher, A.E. Hooper, T. Tighe, R.L. Opila, N. Winograd, D.L. Allara, Nucleation and Growth of Vapor-Deposited Metal Films on Self-Assembled Monolayers Studied by Multiple Characterization Probes in Metallization of Polymers 2, E. Sacher (Ed.), Kluwer Academic/Plenum, New York, NY (2002) 117-126.. ...
It looks like you have javascript turned off. This Roxana Walkers Profile page on EmpowHER Womens Health works best with javascript enabled in your browser ...
Walker Report receives lots of requests to post upcoming political events as well as other kinds of events and if possible we cover them well. We do have a few rules we live by. A candidate can promote their campaign, but we dont post comments derogatory of their opponent. Also we dont post photos with people with eyes closed, open mouth unless they hold a microphone, or it is in context. We dont promote alcohol or cigarettes or unflattering photos. We are a family blog and adhere to those expectations ...
After touring flood-ravaged Wisconsin, Gov. Scott Walker declared the entire state of Wisconsin to be under a state of emergency.
Buy Secretos de la Farmacia Natural by Walker, Lynne Paige at TextbookX.com. ISBN/UPC: 9780130287939. Save an average of 50% on the marketplace.
Khalil, T., Walker, J., Wiener, I., Fagan, C. J., Townsend, C., Greeley, G. H. & Thompson, J. C., 1985, In : Surgery. 98, 3, p. 423-429 7 p.. Research output: Contribution to journal › Article ...
Khalil, T., Walker, J. P., Wiener, I., Fagan, C. J., Townsend, C. M., Greeley, G. H. & Thompson, J. C., 1985, In : Surgery. 98, 3, p. 423-429 7 p.. Research output: Contribution to journal › Article ...
Michael Walker articles and opinion pieces published by Common Dreams, a non-profit independent media outlet publishing since 1997 in Portland, Maine. Page 0
This walker comes with paddle folding mechanism for easy operation. The legs also fold up making it perfect for transportation and storage. Model comes with both extension legs and 5 in. wheels in the
But they dont see obstructions or problems ahead of their path. The really bad injuries tended to be of two types. 1. Stairs. Once the walker rolled over that top step, it would tumble. Once the walker tips over, the babys body and legs are protected, and the full impact lands on the most exposed part of the baby: the head. 2. Pulldown. As every puppy knows, theres a lot of interesting and delicious things on tabletops that they just cant see. The baby who cant walk now has the walker to get them over to the side of the table or the side of the stove or ironing board. The walker keeps them upright in a position they are not developmentally capable of doing on their own. With both of these new capabilities, they can finally indulge their curiosity to see what happens when they pull on the handle of that brightly-colored pot on the stove they are standing right next to ...
Charlotte Hornets are not an NBA playoff team. What do they do to become one? One way, they trade their most valuable commodity, Kemba Walker.
Weve grown accustomed to some campaign gibberish, but Walker insisting that theres no such thing as a hypothetical is just bizarre.
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With 975 cubic inches of storage in addition to its 70-ounce integrated reservoir, the CamelBak Cloud Walker 18 hydration pack is perfect for high-performance day hiking.
SIGNATURE MOMENT: Hudie Joyce Walker prepares to sign papers in which she pleads no contest to manslaughter in the shooting of her abusive husband in 1990. She had been convicted of murder. With her is attorney Beth Collins-Burgard. (Irfan Khan / LAT ...
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Republican National Committee Chairman Reince Priebus says Wisconsin Gov. Scott Walker will be a featured speaker at the upcoming GOP convention.
Todays talk you mightve missed:Everyone grieves in different ways, and artist RZA has chosen to mourn for Paul Walker with a song called Destiny Bends.
Everyone in Westeros has a motive. Littlefinger was a puppet master; Varys is the purest type of survivor; Cersei will do absolutely anything necessary to keep her seat on the Iron Throne. The White Walkers are no different. While Game of Thrones has focused on the journeys of ...
One thought.. I would suspect that the 9th Circuit Court of Appeals will uphold Walkers ruling AND that they know that this will eventually go to SCOTUS.. That being said, assuming ALL justices involved in this lawsuit are FULLY AWARE that this will go to SCOTUS… it is far better to lean towards the side of caution vs. not. In other words, its better to be fair (or even give the anti-equality side a bone) vs. doing anything that may appear as prejudicial, inappropriate, etc. If all the Ts are crossed and all of the Is are dotted it will be increasingly difficult for SCOTUS to find ANYTHING that could cause Walkers ruling to be overturned.. Again, just a thought. The 9th Circuit judges arent dumb. They know that this is a landmark case. If they are liberally minded they will NOT want to screw this up. Theyll do everything they can to ensure Walkers ruling stands.. ...
Walker remembers the day Sjodins body was found in northwest Minnesota.. She and others were handing out sandwiches to some of the dozens of volunteers who had donated months of their time looking for the missing 22-year-old UND student abducted five months earlier.. Then she got a call telling her to come to the "command station," a trailer behind the Crookston High School.. "Nobody said a word in the car on the way back to the trailer," Walker said.. The search may have ended in April 2004, but the story was far from over. What followed was a long legal battle that revealed graphic details into Sjodins death. Court documents laid out how Rodriguez, who had been released from prison in May 2003 after serving a 23-year sentence for stabbing and kidnapping a woman, "carried out a depraved rape fantasy dating back to his previous offenses" before killing her.. "None of it made sense," Walker said. "Why would anyone take someone who is so kind, so loving, so caring toward others?". The region ...
Itll be very intesting to see what happens. I just hope I dont make a total fool of myself next week, and still manage to get everything else done too, as I will still be cleaning (10hr 15min) and site visiting (c 5hr 30min if I do it all in one go and the traffics not too bad, more if it is or I have to split it up over a few days) as well as what ever the boss has in mind! I think I have some long hours ahead of me, and a real challenge for a change ...
It all went a bit wrong at just about 7.45 when Jack thought it would be a good idea to demo his Jujitsu on Tom. And he wasnt holding back. A few swift kicks to Toms knee and I had to call an end to the night very abruptly. Its all just giddiness and Tom wasnt hurt - he puts on a good show but 10 seconds later hes fine - but I declared it bedtime ...
DEAD Mutations Part 1. Naruto started to stir. He heard echoes of gun fire and people screaming.. System restart, switching to core functions. Naruto felt more of himself now, he was beginning to move more of his body.. "Hey buddy you alright!?" A man started to shake Naruto.. Restart complete. Naruto was fully aware of himself now. "Huh? What happened?". "Nows not the time! We need you zombies are overrunning us!" The man handed him his SCAR.. "You dont need to tell me twice!" Naruto went to work taking out any walkers that came near the front line of men fighting the undead. But there were too many of them and not enough ammo. He took out a siren grenade and tossed it near the center of the horde. The horde of zombies stopped their advance and went to the sound of the grenade. When it blew many were killed. Naruto used his HUD to pinpoint the rest of the walkers that made their way inside the perimeter. Getting perfect head shots with the few that the grenade didnt kill.. When the court ...
April Walker-a truly inspiring businesswoman whos been on top of the urban fashion scene for a minute now-is ready to relaunch her classic streetwear brand,
I know of two simple proofs for the theoretical probability of the walker arriving at either barrier given the integer starting position of the walker. One uses an area analysis and the other a tree diagram. You can obtain a free copy (PDF format) of either or both proofs by sending an e-mail request to [email protected] ...
Adults who exercise by walking 2 1/2 to 4 hours a week have healthier cholesterol levels than comparable adults who don`t walk, a Bringham Young University study has found.The study of 3,621 adults
When youre on your feet, do you like to get up a bit of speed or are you more of a slow coach? If youre a stroller rather than a racer it could be time to start picking up the pace. Why? Because acc...
Система экологического контроля в России. лохотрон на сайте знакомств молодили его. Раскосые темные глаза, обрамленные длинными ресницами, ярко секс знакомства дубна поправить ее, но не успела дотронуться, как мне почудилось, будто Я задумался, известно ли ей, как много на самом деле зависит от успеха наших поисков и какая тень лежит на нашем пути, но по ее лицу мне не удалось ничего больше угадать. Она помогла дяде выйти, и мы последовали за ними по торжественным деревянным галереям, окаймлявшим двор. Ранов плелся позади с сигареткой в руке. ...
Our team is excited to learn more about you and your pets so that we can provide outstanding service. Please take the next 10 minutes to provide us with additional information by completing our new client form so we can match you with the most qualified dog walker or pet sitter on our staff.. ...
Located in the Binna Burra section of Lamington National Park, this circuit takes walkers through a fascinating variety of forest and heath.
A wide variety of specialty health services in Walker County are available at Huntsville Memorial Hospital. Contact your nearest clinic today!
Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM (2011). Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic ...
Technical writer, wife, mother and dog walker, I am still learning to express my creative side freely. Knitting is the barometer of my life ...
In 1978, James Cutting published an algorithm to generate point-light displays that resemble the movements of the joints of a human walker. The method has since been used frequently to create stimuli for research on biological motion perception. More recently, Troje and Westhoff (2006) found that pattern of local movement of the feet was used to derive the direction in which a point-light walker is facing, even when structural information is removed. The results of previous studies that direction could not be determined using a scrambled version of Cuttings walker, may be explained by the significantly different motion of the feet between Cuttings walker and motion-captured humans.. To compare the two stimuli, 14 participants performed a detection task and a direction task. Walkers consisted of 11 points presenting a sagittal view. In the detection task, walkers were embedded in a scrambled walker mask consisting of 50, 100, or 200 dots. Participants had to decide which of two successive ...
This is a very difficult sport to play," LSU coach Les Miles said. "Injuries occur, and sometimes its very serious. We all need to give a prayerful eye toward Devon Walker." Walker plays for Tulane, not LSU. But after the Tigers crushed Washington 41-3 Saturday night, Miles began his postgame news conference talking about Walker, not Washington. He spoke for every football fan in America, but thats all he could do. All anyone can do is sympathize over a 21-year-old who broke his neck Saturday trying to make a tackle. It would be pointlessly hypocritical to use the accident to beat up on football. Nobody did anything wrong. Walker knew the risks when he stepped on the field against Tulsa. The odds were about 100,000 to 1 that hed suffer a spinal cord injury in a college game. Walker just happened to be the unlucky one. It was the same with Darryl Stingley, Mike Utley, Adam Taliaferro, Chucky Mullins and other players whose names remind us of things wed rather forget. We just accept them as ...
article{Schneider-walker1997, author = "T. D. Schneider", title = "Sequence Walkers: a graphical method to display how binding proteins interact with {DNA} or {RNA} sequences", journal = "Nucleic Acids Res.", volume = "25", note = "\htmladdnormallink {https://doi.org/10.1093/nar/25.21.4408} {https://doi.org/10.1093/nar/25.21.4408}, \htmladdnormallink {http://alum.mit.edu/www/toms/papers/walker/} {http://alum.mit.edu/www/toms/papers/walker/}, erratum: NAR 26(4): 1135, 1998", pages = "4408--4415", pmid = "9336476", pmcid = "PMC147041", year = "1997 ...
A new poll shows a close race between Republican Gov. Scott Walker and Democratic challenger Mary Burke.. The Marquette law school poll released Monday says 47 percent of registered voters would vote for Walker and 41 percent support Burke. The margin of error is plus or minus 3.5 percentage points. A Marquette poll conducted in October showed Walker with a smaller edge over Burke, 47 percent to 45 percent. Pollster Charles Franklin says the numbers suggest people are still making up their minds about Burke, a former executive with Trek Bicycle Corp. He says its interesting that Walkers number didnt go up, considering that he has a 51 percent approval rating. The poll of 802 registered voters was conducted from Jan. 20 through Thursday, with about 700 interviews conducted before the governors State of the State address last week.. ...
We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old man was operated on for a polypoid tumor of the distal esophagus. Histologically, this tumor was composed of ductal structure
Herein we report a carcinosarcoma with distinct epithelial and mesenchymal components, at the morphological, immunohistochemical and ultrastructural levels. Moreover, the sarcomatous component was composed of cells reminiscent of smooth muscle differentiation and cells with osteoblastic appearance. Some authors classified as large bowel carcinosarcomas epithelial tumours with areas of sarcomatoid differentiation, weakly immunoreactive for cytokeratins and with no evidence of osteosarcomatous nor chondrosarcomatous differentation [12, 13, 20, 21]. According to Aramendi et al., these cases are not properly carcinosarcomas, but should be considered sarcomatoid poorly differentiated carcinomas [23]. In the present case, the sarcomatous component completely lacked any epithelial signs of differentiation; furthermore, we noted areas of osteosarcomatous differentiation and osteoid material deposition. The topographic distribution was remarkable for the complete separation of the two components. ...
Definition of angiogenesis factor in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is angiogenesis factor? Meaning of angiogenesis factor as a legal term. What does angiogenesis factor mean in law?
A report released last week by Citizen Action of Wisconsin reveals health consumers in Wisconsin will pay on average a stunning 79 percent to 99 percent more for health insurance than their counterparts in Minnesota on the new marketplaces created by Obamacare.. The report shows that two decisions made by Gov. Walkers administration explain a substantial portion of the disparity. The fundamental difference between the two states, which are similar geographically and demographically, and have comparable underlying medical costs, is that Minnesota has embraced the national health care reform law and is using the tools it provides to deliver more affordable health insurance, while the Walker administration has tried to undermine the law at every turn.. One bad decision involved Badgercare. It is already well known that Walkers decision to reject enhanced federal Medicaid funding to strengthen Badgercare cost the state budget $119 million more to cover fewer people. Our new report shows that ...
CHICAGO - Wisconsin Secretary of Administration Mike Huebsch has been alongside Governor Scott Walker during dark times as well as stunning victories. Thursday night, Huebsch was called on to stand in for Walker at the Heartland Institutes annual fundraiser. Walker...
Walkers for foot and ankle injuries. Aircast walkers, Aircast XP, Aircast SP, Aircast FP and Aircast Diabetic Walker. Free fast delivery.
ProBasics Bariatric Walker with Dual Wheels - Get the lowest price on ProBasics Bariatric Walker with Dual Wheels, online at AllegroMedical.com.
Michael Walkers hopes of winning the Victorian jockeys premiership are all but over with the leading rider sidelined due to a recurring back injury. Walker, who trails Dean Yendall by four winners in the premiership race, will out of the saddle until at least next week. Spillway, Michael Walker He was stood down with
Lumex ColorSelect folding adult walkers are the ideal complete folding walker solution with a little style. Six attractive colors to choose from and includes popular 5 ...
Synonyms for angiogenesis factor in Free Thesaurus. Antonyms for angiogenesis factor. 37 synonyms for factor: element, thing, point, part, cause, influence, item, aspect, circumstance, characteristic, consideration, component, determinant.... What are synonyms for angiogenesis factor?
Shelby Walker (February 27, 1975 - September, 24, 2006) was an American professional boxer and mixed martial artist. Walker, also known as Shelby Girl, was born as Shelby Rogers. After five years in active duty and in the reserve of the US Army, Walker began her career as an mixed martial artist. Of her six MMA bouts, she won three and lost three. In 2002, Walker became a professional boxer. In her boxing career, she completed 14 bouts. She won seven (six of them by K.O.), lost six and reached a draw. "Interview with Shelby Walker - BoxingInsider.com". 15 April 2008. Retrieved 2 July 2017. "Shelby Walker Fights for Boxing Title". www.mmaweekly.com. Retrieved 1 July 2017. Sherdog.com. "Shelby Walker Passes Away of Apparent Drug Overdose". Sherdog. Retrieved 1 July 2017. "Shelby Girl Walker Found Dead - The Sweet Science". Retrieved 1 July 2017 ...
Welcome to the eOrthopod Local Pages. Here you can find local information about Elbow Joint Replacement in Walker, LA. We have compiled a list of businesses and services around around Walker, including Orthotists & Prosthetists, and Orthopedic Surgeons that should help you with your search. In order to better help you find what you are looking for, the rest of the information on this page has also been targeted to Artificial Limbs. We hope this page helps satisfy your local needs.
Carcinosarcomas are malignant tumors that consist of a mixture of carcinoma (or epithelial cancer) and sarcoma (or mesenchymal/connective tissue cancer). Carcinosarcomas are rare tumors, and can arise in diverse organs, such as the skin, salivary glands, lungs, the esophagus, pancreas, colon, uterus and ovaries. Four main hypotheses have been proposed for the cellular origins of carcinosarcoma, based largely on the pathology of the disease. First, the collision tumor hypothesis, which proposes the collision of two independent tumors resulting in a single neoplasm, based on the observation that skin cancers and superficial malignant fibrous histiocytomas are commonly seen in patients with sun-damaged skin; second, the composition hypothesis, which suggests that the mesenchymal component represents a pseudosarcomatous reaction to the epithelial malignancy; third, the combination hypothesis, which suggests that both the epithelial and mesenchymal components of the tumor arise from a common ...
Wednesday December 4, 2013 the Los Angeles County Coroners Office revealed the autopsy results of both Paul Walker and Roger Rodas. The results do not include the toxicology findings which the coroners office said will be ready about six to eight weeks from now. While the cause of the crash is still under investigation at least the families of both men now know what caused their death. Walker died from blunt force trauma and fatal burning injuries, while Rodas died from the force trauma before the flames engulfed him.. According to the LA County Coroner, the men died from a combination of blunt force trauma and thermal injuries that were caused by the Saturday Nov. 30 one-car accident. The breakdown of findings per individual has 38 year-old Roger Rodas dying from the impact of the crash. Rodas death was not caused by burning as the cars violent impact with the light pole and tree killed him. Walker did not die from the blunt force trauma injuries but burnt to death in the fierce blaze that ...
Fishpond Australia, HJHY® Walking aids, Walker Aluminium alloy With front wheel Old man Four feet crutches Telescopic fold Rehabilitation Walker. Buy Health online: HJHY® Walking aids, Walker Aluminium alloy With front wheel Old man Four feet crutches Telescopic fold Rehabilitation Walker, , Fishpond.com.au
Fast & Furious actor Paul Walker died from "combined effects of traumatic and thermal injuries," a coroners report has revealed.. The LA coroner published the results of an autopsy on the 40-year-old actor who died in a car crash along with a friend last Saturday.. Pauls friend and the driver of the Porsche Carrera GT, Roger Rodas, died of multiple traumatic injuries.. The coroner ruled that both deaths were accidents and said that the injuries occurred when the sports car hit a fixed object in Valencia, north of Los Angeles.. Paul and Roger had been attending a fundraiser organised by the actors charity Reach Out Worldwide when they decided to take the new Porsche out for a spin.. The handsome actor leaves behind 15-year-old daughter Meadow and his long-term girlfriend Jasmine Pilchard-Gosnell who he had dated for seven years. According to reports, Jasmine was beginning to become like a stepmother to Meadow.. Tributes poured in from family, friends, fans and fellow actors after the news of ...
1. This study examined the influence of brisk walking on skeletal status in post-menopausal women.. 2. Subjects were 84 healthy women aged 60-70 years who were previously sedentary and at least 5 years post-menopausal. Subjects were randomly assigned to walking (n = 43) and control (n = 41) groups. Walkers followed a 12-month, largely unsupervised programme of brisk walking. The bone mineral density of the lumbar spine, femoral neck and calcaneus and broadband ultrasonic attention of the calcaneus were measured at baseline and after 12 months.. 3. Forty control subjects and 38 walkers completed the study. Walkers built up to 20.4 ± 3.8 min/day (mean ± SD) of brisk walking. Body mass increased in control subjects relative to walkers [mean change (SE) ± 0.9 (0.3) and −0.1 (0.3) kg respectively; P = 0.04]. Predicted maximum oxygen uptake increased in walkers by 2.1 (0.9) ml min−1 kg−1 (P = 0.02). Bone mineral density in the lumbar spine and calcaneus fell in control subjects [-0.005 ...

Walker Carcinoma 256 - Medical Dictionary online-medical-dictionary.orgWalker Carcinoma 256 - Medical Dictionary online-medical-dictionary.org

Walker Carcinoma 256. A transplantable Carcinoma of the rat that originally appeared spontaneously in the Mammary Gland of a ... pregnant albino rat, and which now resembles a Carcinoma in young Transplants and a Sarcoma in older Transplants. (Stedman, ...
more infohttp://www.online-medical-dictionary.org/definitions-w/walker-carcinoma-256.html

Walker carcinoma 256 - RightDiagnosis.comWalker carcinoma 256 - RightDiagnosis.com

Walker carcinoma 256 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health ... Walker *Carcinoma Terms associated with Walker carcinoma 256:. The following terms can be used for Walker carcinoma 256. * ... Walker carcinoma 256: Related Topics. These medical condition or symptom topics may be relevant to medical information for ...
more infohttps://www.rightdiagnosis.com/medical/walker_carcinoma_256.htm

Antiproliferative and Cytotoxic Activities | SpringerLinkAntiproliferative and Cytotoxic Activities | SpringerLink

Human pancreatic carcinoma cell lines. MDR P-gp CEM/ADR5000 cells. Multidrug-resistant P-gp over expressing CEM/ADR5000 ... floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem Biol Interact 228:46-56CrossRefGoogle Scholar ... Carlisi D, DAnneo A, Angileri L et al (2011) Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the ... Parthenolide cooperates with NS398 to inhibit growth of humanhepatocellular carcinoma cells through effects on apoptosis and G0 ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-78274-4_13

Decreased anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease. -...Decreased anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease. -...

... rTSH and rGH and beta-TSH mRNA and GH mRNA in the anterior pituitary of euthyroid rats bearing the Walker 256 carcinoma. The ... Rats bearing the Walker 256 carcinoma have decreased pituitary nuclear T3 but normal pituitary TSH content and response to ... Rats bearing the Walker 256 carcinoma have decreased pituitary nuclear T3 but normal pituitary TSH content and response to ... Decreased anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease.. *. ...
more infohttps://www.semanticscholar.org/paper/Decreased-anterior-pituitary-T3-nuclear-receptors-Hupart-Defesi/e024844fef6675fce373867a65eaf3eb4178eaec

Comparison of Tacrolimus and Myfortic Versus Tacrolimus and SirolimusComparison of Tacrolimus and Myfortic Versus Tacrolimus and Sirolimus

Walker. A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino ... rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed) ...
more infohttps://www.bioportfolio.com/resources/trial/69525/Comparison-of-Tacrolimus-and-Myfortic-Versus-Tacrolimus-and-Sirolimus.html

Cyclosporin safety in a simplified rat brain tumor implantation modelCyclosporin safety in a simplified rat brain tumor implantation model

Waki Y, Miyamoto K, Kasugai S, Ohya K. Osteoporosis-like changes in Walker carcinoma 256-bearing rats, not accompanied with ... Lima TM, Lima MM, Almeida DC, Mendonça JR, Curi R. Cachexia induced by Walker 256 tumor growth causes rat lymphocyte death. ... A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel ... Production of cachexia mediators by Walker 256 cells from ascitic tumors. Cell Biochem Funct 2008;26: 731-738. [ Links ]. ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000100011&lng=en&nrm=iso&tlng=en

Principles of Geriatric Surgery | Springer for Research & DevelopmentPrinciples of Geriatric Surgery | Springer for Research & Development

Adam DJ, Craig SR, Sang CTM, Cameron EWJ, Walker WS. Esophagectomy for carcinoma in the octogenarian. Ann Thorac Surg 1996;61: ... Adam DJ, Craig SR, Sang CTM, Cameron EWJ, Walker WS. Esophagectomy for carcinoma in the octogenarian. Ann Thorac Surg 1996;61: ... Gastric carcinoma in patients over 70 years of age. Br J Surg 1995;82:102-105.PubMedCrossRefGoogle Scholar ... Treatment of carcinoma of the breast in the older geriatric patient. Surg Gynecol Obstet 1991;173:465-469.PubMedGoogle Scholar ...
more infohttps://rd.springer.com/chapter/10.1007/978-1-4757-3432-4_6

Staff Profile - Institute for Cell and Molecular Biosciences - Newcastle UniversityStaff Profile - Institute for Cell and Molecular Biosciences - Newcastle University

The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand ... Molecular and General Genetics 1997, 256(6), 638-51.. *Lydall D, Weinert T. Use of cdc13-1-induced DNA damage to study effects ...
more infohttp://www.ncl.ac.uk/camb/staff/profile/davidlydall.html

Modification of the endoplasmic reticulum in some mammalian oocytes.Modification of the endoplasmic reticulum in some mammalian oocytes.

mitotic cells of Walker 256 carcinoma. J. BioThey might, in this manner, express rephys. Biochem. Cytol., 11: 227-236. gional ...
more infohttps://www.docme.ru/doc/2179258/modification-of-the-endoplasmic-reticulum-in-some-mammali..

A Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian CancerA Study of the Safety and Pharmacokinetics of AGS-8M4 Given in Combination With Chemotherapy in Women With Ovarian Cancer

Walker. A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino ... There are 3 types of breast carcinoma in situ: DUCTAL CARCINOMA IN SITU; LOBULAR CARCINOMA IN SITU; and PAGET DISEASE OF THE ... It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of ... Breast Carcinoma In Situ. A condition in which abnormal cells have not spread outside the duct, lobule, or nipple to other ...
more infohttps://www.bioportfolio.com/resources/trial/70697/A-Study-of-the-Safety-and-Pharmacokinetics-of-AGS-8M4-Given-in.html

Carcinosarcoma - definition of carcinosarcoma by The Free DictionaryCarcinosarcoma - definition of carcinosarcoma by The Free Dictionary

... a malignant neoplasm composed of carcinoma and sarcoma extensively... ... n a malignant tumour composed of carcinoma and sarcoma Noun 1. carcinosarcoma - ... Walker 256 carcinosarcoma, melanoma, Lewis lung carcinoma or leukemia cells.. Amygdalin, quackery or cure? ... Sarcomatoid carcinoma is recommended terminology by WHO for such lesions and carcinosarcoma is used as synonym for these ...
more infohttps://www.thefreedictionary.com/carcinosarcoma

Acidic pH enhances the invasive behavior of human melanoma cells | SpringerLinkAcidic pH enhances the invasive behavior of human melanoma cells | SpringerLink

1992, Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. Int J Cancer, 50, 36-44.Google Scholar ... Sevick, EM and Jain, RK, 1988, Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia. Cancer ... Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonization ability of Lewis lung carcinoma cells. ...
more infohttps://link.springer.com/article/10.1007%2FBF00121214

US Pivotal Studies of Irinotecan in Colorectal Carcinoma | Cancer Network | The Oncology JournalUS Pivotal Studies of Irinotecan in Colorectal Carcinoma | Cancer Network | The Oncology Journal

Walker 256 carcinosarcoma. Cancer Chemother Rep 52:229-242, 1968.. 11. Gottlieb JA, Guarino AM, Call JB, et al: Preliminary. ... carcinoma. J Clin Oncol 6:469-475, 1988.. 7. Leichman CG, Fleming TR, Muggia FM, et al: Phase II study of. fluorouracil and its ... carcinoma. J Clin Oncol 15:2910-2919, 1997.. 34. Conti JA, Kemeny NE, Saltz LB, et al: Irinotecan is an active. agent in ... year, colorectal carcinoma will result in an estimated 55,000 deaths,. remaining the second most common cause of cancer-related ...
more infohttp://www.cancernetwork.com/review-article/us-pivotal-studies-irinotecan-colorectal-carcinoma

Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and...Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and...

Walker 256 carcinosarcoma cells (2.5 × 105 in approximately 0.5 mL of 0.9%, w/v, NaCl), originally obtained from the Arthur ... Zhang J, Chan EK: Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma ... Influence of Walker 256 tumour and ascitic fluid on foetal and placental parameters. The foetal and placental ratio was altered ... Influence of Walker 256 tumour and ascitic fluid on the immunohistochemical detection of placental cleaved PARP, cytochrome-c ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-6-168

Histologic and biologic response of tumours to irradiation | Springer for Research & DevelopmentHistologic and biologic response of tumours to irradiation | Springer for Research & Development

Fogg, L.C., and S. Warren: A comparison of the cytoplasmic changes induced in the Walker rat carcinoma 256 by different types ... Lumb, G.: Changes in carcinoma of the breast following irradiation. Brit. J. Surg. 38, 82-93 (1950).PubMedGoogle Scholar ... Graham, R.M.: The effect of radiation on vaginal cells in cervical carcinoma. Surg. Gynec. Obstet. 84, 153-173 (1947).PubMed ... Price-Jones, C., and J.C. Mottram: A contribution to the study of in vitro plasma cultures of mouse carcinoma and rat sarcoma. ...
more infohttps://rd.springer.com/chapter/10.1007%2F978-3-662-39628-5_13

https://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdqhttps://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdq

... mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. Not effective ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ...
more infohttps://www.cancer.gov/about-cancer/treatment/cam/hp/laetrile-pdq

Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal...Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal...

S. J. Medhurst, K. Walker, M. Bowes et al., "A rat model of bone cancer pain," Pain, vol. 96, no. 1-2, pp. 129-140, 2002. View ... Q.-L. Mao-Ying, J. Zhao, Z.-Q. Dong et al., "A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 ... mammary gland carcinoma cells," Biochemical and Biophysical Research Communications, vol. 345, no. 4, pp. 1292-1298, 2006. View ...
more infohttps://www.hindawi.com/journals/mi/2016/5093095/ref/

Taheebo Uses, Benefits & Dosage - Drugs.com Herbal DatabaseTaheebo Uses, Benefits & Dosage - Drugs.com Herbal Database

... including Walker 256 carcinoma, prostate cancer, human promyelocytic leukemia, breast cancer, ovarian cancer, epidermoid ...
more infohttps://www.drugs.com/npp/taheebo.html

Alternatives in Cancer Therapy - Hydrogen PeroxideAlternatives in Cancer Therapy - Hydrogen Peroxide

Reginald Holman tested H2O2 on rats implanted with Walker 256 adenocarcinoma tumors. Their drinking water was replaced by a ... Winifred Wirth reported on the effective use of oral H2O2 in the treatment of laboratory mice infected with Ehrlich carcinoma. ...
more infohttp://educate-yourself.org/cn/hydrogenperoxidecancertherapybookexcerpt.shtml

Plus itPlus it

Lewis lung carcinoma, Human sarcoma HS1, Hepatoma 129, Walker 256 (intramuscular) and Cloudman melanoma (S91). Data are ... Almost all of the compounds were tested in Sarcoma 180, Carcinoma 755, Leukemia 1210, and KB cells in culture; some tests were ...
more infohttp://cancerres.aacrjournals.org/content/25/9_Part_2/1626

natural cancer cures - The Skeptics Dictionarynatural cancer cures - The Skeptic's Dictionary

... caused complete regression of Walker carcinoma 256 [a type of rat breast carcinoma cell line] in rats in 50-60 per cent of the ...
more infohttp://skepdic.com/naturalcures.html

https://www.cancer.gov/about-cancer/treatment/cam/hp/mistletoe-pdqhttps://www.cancer.gov/about-cancer/treatment/cam/hp/mistletoe-pdq

... was used to treat rats bearing chemically induced mammary carcinomas or tumors formed from rat Walker 256 carcinosarcoma cells ... Renca renal cell carcinoma, and F9 testicular carcinoma) but not from two other mouse cancers (B16 melanoma and Lewis lung ... Hepatocellular carcinoma. 23; 23; none. Improved survival No. 2Dii. Current Clinical Trials. Use our advanced clinical trial ... Human ductal breast carcinoma cell line BT474. As compared with tumors of control mice, tumors of the ME-A- and ME-M-treated ...
more infohttps://www.cancer.gov/about-cancer/treatment/cam/hp/mistletoe-pdq

Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator...Iguratimod prevents ovariectomy‑induced bone loss and suppresses osteoclastogenesis via inhibition of peroxisome proliferator...

It has previously been demonstrated that iguratimod attenuates bone destruction and osteoclast formation in the Walker 256 rat ... mammary gland carcinoma cell‑induced bone cancer pain model. Therefore, it was hypothesized that iguratimod may additionally ...
more infohttps://www.spandidos-publications.com/mmr/16/6/8200/abstract
  • Such association has been mentioned in several case reports as in renal cell carcinoma, (1) uterine carcinosarcoma (2) etc. (thefreedictionary.com)
  • On April 19, 2019, the Food and Drug Administration (FDA) of the USA approved the combination of pembrolizumab and axitinib for first-line treatment of patients with advanced renal cell carcinoma based on the results of KEYNOTE-426 trial. (amegroups.com)
  • During the same year, colorectal carcinoma will result in an estimated 55,000 deaths, remaining the second most common cause of cancer-related deaths in the United States. (cancernetwork.com)
  • A phase II study by the Southwest Oncology Group (SWOG) assessed the efficacy and toxicity of seven different regimens of 5-FU in patients with untreated advanced colorectal carcinoma. (cancernetwork.com)
  • Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment. (bioportfolio.com)
  • Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patient. (bioportfolio.com)
  • In this study, the ability of gefitinib to modulate intratumoral oxygenation was evaluated in human EGFR-expressing A431 squamous cell carcinoma xenografts using in vivo small animal positron emission tomography (PET) imaging with the hypoxia marker [ 18 F]fluoroazomycin arabinoside (FAZA) and by the immunohistochemical detection of hypoxia-induced adducts of the 2-nitroimidazole, pimonidazole. (aacrjournals.org)
  • In this study, the ability of gefitinib to modulate oxygenation in human epidermal growth factor receptor expressing A431 squamous cell carcinoma xenografts was examined using in vivo small animal positron emission tomography (PET) imaging with FAZA. (aacrjournals.org)
  • Aim: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatinresistant and cisplatin-sensitive variants of Guerin carcinoma. (nbuv.gov.ua)
  • Carcinoma of the colon and rectum remains one of the most common malignant diseases afflicting people living in industrialized countries. (cancernetwork.com)
  • Then, a mutation in another growth pathway, either Ki-Ras/BRAF, Smad4/TGFβ, PI3K, or TP53/BAX occurs when the adenoma becomes larger, leading to carcinoma. (biomedcentral.com)
  • Foi desenvolvido um modelo animal simplificado de tumor cerebral em ratos utilizando a linhagem celular W256 (carcinoma 256 de Walker) para permitir teste de novos tratamentos. (scielo.br)