Walking aids generally having two handgrips and four legs.
A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Equipment and furniture used by infants and babies in the home, car, and play area.
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Nonexpendable items used in the performance of orthopedic surgery and related therapy. They are differentiated from ORTHOTIC DEVICES, apparatus used to prevent or correct deformities in patients.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Tumors or cancer of the LUNG.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
Sticks used as walking aids. The canes may have three or four prongs at the end of the shaft.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the SKIN.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Manner or style of walking.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
DNA present in neoplastic tissue.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumors or cancer of the UTERINE CERVIX.
Devices, not affixed to the body, designed to help persons having musculoskeletal or neuromuscular disabilities to perform activities involving movement.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Elements of limited time intervals, contributing to particular results or situations.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Resinous substances which most commonly originate from trees. In addition to resins, they contain oils, cinnamic acid and BENZOIC ACID.
Wooden or metal staffs designed to aid a person in walking. (UMDNS,1999)
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Tumors or cancer of the VAGINA.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Tumors or cancer of the BRONCHI.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
RNA present in neoplastic tissue.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Transplantation between animals of different species.
Established cell cultures that have the potential to propagate indefinitely.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Antibodies produced by a single clone of cells.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
To move about or walk on foot with the use of aids.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Tumors or cancer of the RECTUM.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Experimentally induced tumors of the LIVER.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
The process of cleaving a chemical compound by the addition of a molecule of water.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Tumors or cancers of the ADRENAL CORTEX.
The epithelial lining of the URINARY TRACT.
Tumors or cancer of the VULVA.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Tumors or cancer of the OROPHARYNX.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Efforts and designs to reduce the incidence of unexpected undesirable events in various environments and situations.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
The forepart of the foot including the metatarsals and the TOES.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Compounds that include the amino-N-phenylamide structure.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the BILE DUCTS.
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
The real or apparent movement of objects through the visual field.
Tumors or cancer of the URINARY TRACT in either the male or the female.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Tumors or cancer located in bone tissue or specific BONES.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Organic salts and esters of benzenesulfonic acid.
Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Gait abnormalities that are a manifestation of nervous system dysfunction. These conditions may be caused by a wide variety of disorders which affect motor control, sensory feedback, and muscle strength including: CENTRAL NERVOUS SYSTEM DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; or MUSCULAR DISEASES.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Proteins prepared by recombinant DNA technology.
Biochemical identification of mutational changes in a nucleotide sequence.
Excision of all or part of the liver. (Dorland, 28th ed)

Applicability of 99mTc-HL91, a putative hypoxic tracer, to detection of tumor hypoxia. (1/243)

To elucidate the applicability of 99mTc-HL91 (HL91) a putative hypoxic tracer, to the imaging of hypoxia in tumors, a biodistribution study of the tracer was performed. The intratumoral distribution of HL91 was compared with that of 14C-deoxyglucose (DG) and the expression of glucose transporter 1 (GLUT1) in an implanted tumor. METHODS: Biodistribution of HL91 after intravenous injection into Wistar rats with rat mammary tumor (Walker-256) was studied by determining blood and tissue levels of radioactivity from 15 min to 6 h after injection. Dual ex vivo autoradiography was performed on sections of the tumor using HL91 (74 MBq) and DG (185 kBq). The same sections were immunohistologically analyzed with anti-GLUT1 antibody. Tumor tissue was histologically divided into areas of viable cancer cells, necrosis and granulation tissue. The viable cancer cell area was further divided into normoxic and hypoxic areas. Uptake of both tracers in each area was measured quantitatively. The intensity of GLUT1 staining (relative optical density [ROD]) in each area was evaluated by densitometry. RESULTS: The uptake of HL91 in the tumor reached a maximal value (0.897 +/- 0.118% ID [injected dose], mean +/- SD, n = 5) at 120 min after intravenous injection of HL91, then gradually decreased. The tumor-to-muscle ratio continued to increase until 360 min (4.34 at 120 min, 7.01 at 240 min and 10.4 at 360 min). HL91 accumulated to significantly higher levels in the hypoxic area than those in the other tissues (P < 0.0001). Uptake of DG and expression of GLUT1 were significantly higher in the hypoxic area than in the normoxic area (P < 0.0001). In the viable cancer cell area, uptake of HL91 and expression of GLUT1 were strongly correlated (r = 0.624-0.868, mean r = 0.743, P < 0.0001), and DG uptake was moderately correlated with GLUT1 expression (r = 0.328-0.669, mean r = 0.505, P < 0.0001). CONCLUSION: These results indicate that HL91 can be used to detect tumor hypoxia.  (+info)

Postmenopause-like bone loss by mammary carcinoma Walker256/S which secretes luteinizing hormone-releasing hormone. (2/243)

When Walker 256/S carcinosarcoma (W256/S) was subcutaneously inoculated into the back of mature female Wistar Imamichi rats (10-week-old), the tumor grew rapidly and caused increases in the urinary excretions of calcium and hydroxyproline, without changes in the serum concentrations of calcium and inorganic phosphorus. Furthermore, osteoporosis-like changes in the femurs and decrease in uterus weight were observed, as previously reported for W256/S-bearing young rats. In the healthy mature female rats, the estrus cycle passed through four stages (proestrus, estrus, metestrus and diestrus) within 4 to 5 days, with a peak of serum estradiol and progesterone levels in the proestrus stage. On the other hand, after subcutaneous inoculation of W256/S into the rats, the estrus cycle tended to pause upon the metestrus or diestrus stage, accompanied with significantly low estradiol and progesterone levels in serum. W256/S tumor produced and secreted luteinizing hormone-releasing hormone (LH-RH). In conclusion, it seems that the ectopical secretion of LH-RH from the tumor resulted in the decrease in the secretion of gonadotropic hormones, following low level of sex hormones and stopping the estrus cycle. Therefore, W256/S-bearing rats may be a model for osteoporosis of hypoovarianism or postmenopause.  (+info)

Tissue distribution of rat macroglobulins in tumour-bearing rats. (3/243)

Rat macroglobulins were determined in blood sera and extracts of tissues of intact rats and rats with Walker carcinoma by rocket immunoelectrophoresis. The serum levels of alpha1-macroglobulin (alpha1MG) alpha2-macroglobulin (alpha2MG) and pregnancy-associated alpha1-glycoprotein (alpha1PAG) were 1.86 +/- 0.07 mg/ml, 0.12 +/- 0. 02 mg/ml and 18.32 +/- 4.07 AU/ml respectively in control rats. Maximum concentrations of alpha1MG were found in heart, lung and spleen and lesser quantities were in liver and thymus, while alpha2MG and alpha1PAG were not found at all in tissue extracts from control rats. Serum alpha2MG and alpha1PAG concentrations increased more than 30-fold in tumour-bearing rats compared to control animals, while alpha1MG serum concentration was little changed. Increases in all three macroglobulins occurred in the tissues of tumour-bearing rats, particularly alpha1PAG. The tissue concentrations of alpha1MG and alpha2MG were similar and the tissue distribution was also similar with highest concentrations in heart and lung. Considerable quantities of the proteins were found in the tumour and part of peritoneum which made contact with the tumour. Changes in the protein concentrations in serum and tissue extracts of tumour-bearing rats suggest that all members of rat macroglobulin family are disturbed during the development of the Walker carcinoma, though only alpha2MG and alpha1PAG were substantially elevated.  (+info)

Treatment with ibandronate preserves bone in experimental tumour-induced bone loss. (4/243)

Cancer-induced bone diseases are often associated with increased bone resorption and pathological fractures. In recent years, osteoprotective agents such as bisphosphonates have been studied extensively and have been shown to inhibit cancer-related bone resorption in experimental and clinical studies. The third-generation bisphosphonate, ibandronate (BM 21.0955), is a potent compound for controlling tumour osteolysis and hypercalcaemia in rats bearing Walker 256 carcinosarcoma. We have studied the effect of ibandronate given as an interventional treatment on bone strength and bone loss after the onset of tumour growth in bone. Our results suggest that it is capable of preserving bone quality in rats bearing Walker 256 carcinosarcoma cells. Since other bisphosphonates have produced comparable results in man after their success in the Walker 256 animal models our findings suggest that ibandronate may be a powerful treatment for maintaining skeletal integrity in patients with metastatic bone disease.  (+info)

The hemolytic component of cancer anemia: effects of osmotic and metabolic stress on the erythrocytes of rats bearing multifocal inoculations of the Walker 256 tumor. (5/243)

Cancer anemia is classified as an anemia of chronic diseases, although it is sometimes the first symptom of cancer. Cancer anemia includes a hemolytic component, important in the terminal stage when even transfused cells are rapidly destroyed. The presence of a chronic component and the terminal complications of the illness limit studies of the hemolytic component. A multifocal model of tumor growth was used here to simulate the terminal metastatic dissemination stage (several simultaneous inoculations of Walker 256 cells). The hemolytic component of anemia began 3-4 days after inoculation in 100% of the rats and progressed rapidly thereafter: Hb levels dropped from 14.9 +/- 0.02 to 8.7 +/- 0.06 from days 7 to 11 ( approximately 5 times the physiologically normal rate in rats) in the absence of bleeding. The development of anemia was correlated (r2 = 0.86) with the development of other systemic effects such as anorexia. There was a significant decrease in the osmotic fragility of circulating erythrocytes: the NaCl concentration causing 50% lysis was reduced from 4.52 +/- 0.06 to 4.10 +/- 0.01 (P<0.01) on day 7, indicating a reduction in erythrocyte volume. However, with mild metabolic stress (4-h incubation at 37oC), the erythrocytes showed a greater increase in osmotic fragility than the controls, suggesting marked alteration of erythrocyte homeostasis. These effects may be due to primary plasma membrane alterations (transport and/or permeability) and/or may be secondary to metabolic changes. This multifocal model is adequate for studying the hemolytic component of cancer anemia since it is rapid, highly reproducible and causes minimal animal suffering.  (+info)

Vascularization of normal and neoplastic tissues grafted to the chick chorioallantois. Role of host and preexisting graft blood vessels. (6/243)

Adult, embryonic, and tumor tissues were grafted to the chorioallantoic membrane of the chick embryo to determine whether blood vessels originally within implants were reused in the establishment of a new blood supply. Grafts were examined daily by in vivo stereomicroscopy and in histologic sections. Colloidal carbon injections into the host vasculature served to confirm the precise onset of graft circulation; Preexisting tumor blood vessels disintegrated by 24 hours after implantation and revascularization occurred at 3 days by penetration of proliferating host vessels into the tumor tissue. Adult tissues did not revascularize, and the original graft vasculature progressively disintegrated during the 9 days of observation, Most embryonic tissues revascularized in 1 or 2 days by reperfusion of the existing graft vasculature. Anastomosis of host and graft blood vessels seemed to result from connections between newly formed vascular sprouts arising from both vasculatures. This study indicates that only tumor grafts acquire their blood supply solely by formation of new blood vessels from the host microvasculature. By contrast revascularization of normal tissues, when it does occur, is predominately the result of perfusion of the preexisting graft blood vessels.  (+info)

Apparent cellular ingress of albumin in Walker 256 tumor and rat muscle. (7/243)

Tissue albumin distribution was measured in Walker 256 tumor and skeletal muscle in vivo in 36 rats. Vascular, extravascular-extracellular, and total tissue water spaces were determined for each tissue sample by isotopic techniques. Tissue interstitial and lymph albumin values were calculated from thoracic duct albumin concentrations, and vascular albumin was determined from serum albumin levels. Total tissue albumin was measured by dilution. These data demonstrate a third tissue albumin pool that equilibrates in 3 days compared to the rapid equilibration (2 hr) of vascular and extracellular-extravascular spaces. The pool is present in both muscle and tumor but appears to equilibrate more rapidly in tumor tissue. This finding suggests that cellular ingress of albumin occurs in vivo, which may explain increased albumin catabolism in tumor-bearing hosts.  (+info)

Tissue water content and nuclear magnetic resonance in normal and tumor tissues. (8/243)

Pulsed proton nuclear magnetic resonance was used to differentiate between normal and malignant tissues. When the tissue water content varied from 80 to 93%, the tumors exhibited spin-lattice relaxation times (T1) from 0.9 to 1.8 sec. We report also the results obtained on 9-day-old embryos and on liver, brain, and heart from 2-day-old rats. A good correlation between the spin-lattice (T1) and spin-spin (T2) relaxation times and the tissue water content was found for all tissues studied. The relaxation times T1 and T2 and water content in Walker 256 carcinoma and its lymph node metastasis were quite similar.  (+info)

The relationship between tumor physiology and the pharmacokinetics of 2,2 difluorodeoxycytidine [gemcitabine (dFdC)] in ex vivo perfused human small cell lung cancer was examined. Two small cell lung cancer sublines, 54A and 54B, with known in vivo sensitivity to dFdC, were grown as tissue-isolated tumors in athymic mice and perfused ex vivo with or without 20-40 micrometer dFdC. Arteriovenous differences in gases, pH, and metabolites were determined before and during drug infusion. The geometric flow resistance (FR) of individual tumors was calculated, and dFdC and its inactive metabolite 2,2 difluorodeoxyuridine were determined by high-performance liquid chromatography of consecutive samples from the output line. Both tumors had prominent lactate production concurrent with a significant O2 consumption. The arteriovenous pH drop was approximately 0.3 in both tumor lines. Significant metabolic differences between 54A and 54B tumors were found that elucidated previously described differences ...
Modulatory effect of leucine in H9c2 cardiomioblasts under Walker-256 tumor factors. Scholarships in Brazil Scientific Initiation. Maiara Caroline Colombera. Biological Sciences. scholarship by fapesp
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Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer, and is ranked the sixth most common neoplasm and the third leading cause of cancer-related deaths. Photothermal therapy (PTT) for thermal ablation of local tumors has recently emerged as a therapeutic strategy. However, the relatively high temperature of over 50°C may lead to unexpected heat-related damage to tumor-adjacent normal tissues. Herein, we designed and synthesized ataxia telangiectasia mutated (ATM) inhibitor loaded hollow-structured CuS NPs with surface modification with anti-TGF-ß antibody ([email protected]ß NPs). [email protected]ß NPs are highly photo-stable, can release encapsulated drugs, and increase the temperature to an effective level in a near-infrared (NIR)-responsive manner. Moreover, [email protected]ß NPs specifically target tumors and thereby significantly inhibit tumor growth on contribution to synergistic low-temperature PTT and chemotherapy. This system not only achieved low-temperature PTT ...
TY - JOUR. T1 - Carcinosarcoma in the cecum. AU - Ryu, Youngjoon. AU - Kim, Aeree. AU - Kim, Han Kyeom. AU - Lee, Beomjae. AU - Jung, Woonyong. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. AB - Carcinosarcoma of the colon is rare. Seventeen cases have been reported in the English literature. Most cases occurred in the left side of the colon. Indeed, there is only one reported case of cecal carcinosarcoma. Carcinosarcoma has a tendency to distantly metastasize and shows dismal prognosis. We report a case of carcinosarcoma in the cecum and review the literature describing colonic carcinosarcoma.. KW - ...
A transplantable Carcinoma of the rat that originally appeared spontaneously in the Mammary Gland of a pregnant albino rat, and which now resembles a Carcinoma in young Transplants and a Sarcoma in older Transplants. (Stedman, 25th ed ...
Treatment of the 1-day-old Ehrlich ascites tumor with combinations of selected doses of l-asparaginase and the l-glutamine antagonist, 6-diazo-5-oxo-l-norleucine, or of the l-glutamine acid antagonist, dl-methionine-dl-sulfoximine, produced significantly more growth inhibition without a marked increase in host toxicity than did treatment with l-asparaginase administered alone. In the 3-day-old tumor treated with the combination of l-asparaginase and 6-diazo-5-oxo-l-norleucine, there was a significant enhancement of growth inhibition as compared with the effect of either drug used alone. A less significant increase of growth inhibition was obtained with combination of l-asparaginase and l-glutamyl-γ-hydrazide as compared with the effect of this chemical administered alone.. Combinations of l-asparaginase and 6-diazo-5-oxo-l-norleucine produced increased antitumor effects in mouse melanoma B16 and to a lesser degree in the solid form of Ehrlich tumor and Walker carcinosarcoma 256 of the ...
The effect of Walker tumor on sulphacetamide distribution was studied in rats 21 days after tumor implantation in a hind leg. After oral administration of sulphacetamide (5 and 20 min), the concentration of the drug was found to be lower in the plasma and liver of tumor-bearing rats when compared with that of control group. However, 90 min after sulphacetamide administration, the concentration of the drug in these same tissues was found to be higher in tumor-bearing rats than in control animals. Whereas the tumor had no apparent effect on sulphacetamide concentration in the brain, drug concentrations in the fat tissue of tumor-bearing rats were constantly higher than those of control animals. These changes in sulphacetamide disposition kinetics could be explained in part by delay in gastrointestinal absorption of the drug. Contrary to what was observed after oral administration, constantly higher drug concentrations were found in the plasma of tumor-bearing rats after iv injection of ...
During starvation for 72 h, tumour-bearing rats showed accelerated ketonaemia and marked ketonuria. Total blood [ketone bodies] were 8.53 mM and 3.34 mM in tumour-bearing and control (non-tumour-bearing) rats respectively (P less than 0.001). The [3-hydroxybutyrate]/[acetoacetate] ratio was 1.3 in the tumour-bearing rats, compared with 3.2 in the controls at 72 h (P less than 0.001). Blood [glucose] and hepatic [glycogen] were lower at the start of starvation in tumour-bearing rats, whereas plasma [non-esterified fatty acids] were not increased above those in the control rats during starvation. After functional hepatectomy, blood [acetoacetate], but not [3-hydroxybutyrate], decreased rapidly in tumour-bearing rats, whereas both ketone bodies decreased, and at a slower rate, in the control rats. Blood [glucose] decreased more rapidly in the hepatectomized control rats. Hepatocytes prepared from 72 h-starved tumour-bearing and control rats showed similar rates of ketogenesis from palmitate, and ...
TY - JOUR. T1 - A case and literature review of ovarian carcinosarcoma with long-Term survival after repeated recurrences. AU - Asano, Maki. AU - Hasegawa, Kiyoshi. AU - Tsukada, Kazuhiko. AU - Tada, Shin. AU - Mizoguchi, Yoshikazu. AU - Imaeda, Yoshihiro. AU - Ikeda, Mina. AU - Kawamura, Kyoko. AU - Fujii, Takuma. PY - 2014/8/1. Y1 - 2014/8/1. N2 - Ovarian carcinosarcoma is a rare and aggressive tumor with a poor prognosis. We report a case of ovarian carcinosarcoma and also review the literature. In 2000, a 63-year-old woman underwent optimal cytoreductive surgery for ovarian carcinosarcoma (International Federation of Gynaecology and Obstetrics [FIGO] stage 1c [pT3cN0M0]). She received adjuvant chemotherapy with paclitaxel and carboplatin (TC). In 2005, a recurrent tumor was noted anterior to the sacrum. The patient had a complete response after 6 cycles of TC chemotherapy; however, a year later, the tumor recurred and was resected. In 2013, the tumor recurred adjacent to the right kidney and ...
Recently, we demonstrated that verapamil, an L-type Ca2+ channel blocker, inhibits the activation of splenic lymphocytes during Walker 256 ascitic tumor development in adult rats. In the present study we have analyzed the changes in spleen size, splenic lymphocyte proliferation, white pulp organization and relative size as well as food intake, and levels of blood haemoglobin in Walker 256 tumor bearing rats. These rats displayed a spleen enlargement associated with a significant increase in white pulp area and TCD8(+) lymphocyte proliferation. Levels of interferon-gamma, but not of interleukin-10, were elevated in tumor bearing rats, indicating a Th1-type immune response. These manifestations were accompanied by reduced food intake and anaemia. Treatment of tumor bearing rats with verapamil avoided spleen enlargement and increased expression of cytokines, as well as the splenic TCD8(+) lymphocyte proliferation. In addition, verapamil treatment promoted an exacerbation of the anorexia, and ...
Objectives: To compare two different chemotherapy adjuvant treatment regimens currently and previously used at CancerCare Manitoba for endometrial carcinosarcoma. Methods: This is a retrospective analysis of 60 patients diagnosed with primary endometrial carcinosarcoma at CancerCare Manitoba from 1998-2008. The demographic characteristics, malignancy stage, presence of recurrent disease, and treatment type(s) utilized were studied. 37 patients were found to have received either carboplatin/paclitaxel or doxorubicin/cisplatin for carcinosarcoma, and were further analyzed to determine if there was a statistically significant difference in progression-free survival and overall survival between the two treatments. Kaplan-Meier curves were used to display progression-free survival and overall survival. Results: 60.4% of patients presented with low-stage disease. No statistically significant difference in progression-free survival or overall survival between the two cohorts was found. Recurrence rate ...
The client initially expected to have a 4-wheeled walker, but when I took her and her husband out to the CareCo shop in Maybush, Southampton, it was clear that a 4-wheeled walker was too unstable for her, and she purchased a 2-wheel (+ 2 legs) walker.. A crossbar was manufactured to ft between the handles. This is permanently attached and on the left side but free to rotate on the handle, and the walker is fitted with a locking attachment on the right handle for safe retention. Thus the bar enables single-handed use of the walker, but the crossbar may be part-detached and folded back so the client may still use the walker as a seat.. The crossbar is placed between the two handles of a two-wheeled walker. One side is free to rotate on the handle, in order that it may be moved out of the way when seated on the walker. It is retained between two collars attached to the handle. The other end of the crossbar is slotted so it may be swung away from the handle, or placed on ...
On this date we recall Aida Overton Walker, born in 1880. She was a singer, dancer, actress, and choreographer.. Born on Valentines Day in New York City, Aida Overton began her career as a teenage chorus member of Black Pattis Troubadours. While performing in The Senegambian Carnival (1899) she met George Walker, and the two were married on June 22, 1899. After the marriage, Aida Walker worked as a choreographer for Williams and Walker, her husbands vaudevillian comedy duo. By presenting ragtime musicals with all Black casts, Williams and Walker helped bring authentic Black songs and dances to a form of entertainment that had been dominated by demeaning minstrel shows.. Walker played the female lead in The Policy Players (1899), Sons of Ham (1900), In Dahomey (1902), In Abyssinia (1906), and Bandanna Land (1908). A command performance at Buckingham Palace in 1903 transformed Walker into an international star. In 1908, George Walker became ill and could not continue in the run of Bandanna ...
Johnnie Walker Black Label - Boodschappen Korting- bonide eight insecticide label johnnie walker ,Johnnie Walker Black Label actie. Lees nu via internet de mooiste Johnnie Walker Black Label aanbieding. Iedereen wil graag wat bezuinigen. Shirin (33, single) spendeert meestal 213 euro per maand bij Poiesz. Voor Matz & Nicola (getrouwd, kinderen) is dit maar liefst 372 euro. Gelukkig biedt de supermarkt mooie acties.Black Label - Johnnie Walker(id:10169099). Buy United ...Each marque has its own color designation, from red, to black, to green and then gold. At the pinnacle of the Johnnie Walker line is the exceptionally well regarded Blue Label blended Scotch whisky. They are all available in different sizes. Bottles 700, 750, 1000, 4500ml. Gift Boxes and other Whisky products . Johnnie Walker Red, Black, Gold, ...
Long range forecaster Hayden Walker from Walkers Weather is predicting a cyclone will begin developing late February and cross the coast between North and Central Queensland in early March.. The son of Lennox Walker, the world-famous Australian Long Range Weather Forecaster, and the fourth-generation of a remarkable lineage of Forecasters, Mr Walker recently said Im forecasting a tropical cyclone forming in the latter part of February in the Coral Sea and it should affect the coastline at the beginning of March,.. It should make its way south-west … Im forecasting it will affect the northern districts of Queensland to the Central districts of Queensland.. Mr Walker said it was difficult to predict the velocity and extent of the cyclone, but it could potentially wreak havoc across Queensland.. I believe it will be substantial category wise, but we will have to wait and see, he said.. Walkers Weather. Walkers Weather has been going since 1892 and they base their forecasting off sun ...
Tetraspanins function as molecular organizers of multi-protein complexes by assembling primary complexes of a relatively low mass into extensive networks involved in cellular signalling. In this paper, we summarize our studies performed on the tetraspanin D6.1A/CO-029/TM4SF3 expressed by rat carcinoma cells. Primary complexes of D6.1A are almost indistinguishable from complexes isolated with anti-CD9 antibody. Indeed, both tetraspanins directly associate with each other and with a third tetraspanin, CD81. Moreover, FPRP (prostaglandin F2α receptor-regulatory protein)/EWI-F/CD9P-1), an Ig superfamily member that has been described to interact with CD9 and CD81, is also a prominent element in D6.1A complexes. Primary complexes isolated with D6.1A-specific antibody are clearly different from complexes containing the tetraspanin CD151. CD151 is found to interact only with D6.1A if milder conditions, i.e. lysis with LubrolWX instead of Brij96, are applied to disrupt cellular membranes. CD151 ...
1 INTERVIEW WITH EARL WALKER BY JERRY GROVER FEBRUARY 27, 2002 MR. GROVER: Good morning, my name is Jerry Grover. I am here in the Portland area in the little town of Canby. I am here this morning to do an Oral History with, Earl would you state your name? MR. WALKER: Earl Walker. MR. GROVER: Earl what was your title? What were you doing when you retired? MR. WALKER: I was in the Regional Office. MR. GROVER: In Portland? MR. WALKER: Yes, I was in sort of a review position in what was Ecological Services then. It was sort of almost like the old River Basins regional unit. They did away with that when they reorganized so there was no Regional Office Supervisor for Ecological Services. It was done more on a staff basis than on a supervisory basis. I had a lot of other [responsibilities], any time power lines or Indian rights came up, or anything that dealt with policy or procedures came up, that ended up in my lap. MR. GROVER: When did you retire? MR. WALKER: In January on 1981. Its been over ...
During February 1963, Walker joined Billy Hargis in an anti-communist tour named Operation Midnight Ride.[25] In a speech Walker made on March 5, reported in the Dallas Times Herald, he called on the United States military to liquidate the [communist] scourge that has descended upon the island of Cuba.[26] Seven days later, Lee Harvey Oswald ordered by mail a Carcano rifle, using the alias A. Hidell.[27] According to the Warren Commission, Oswald began to put Walker under surveillance, photographing the generals Dallas home on the weekend of March 9-10.[28] Oswalds friend, 51-year-old Russian émigré and petroleum geologist George de Mohrenschildt,[29] would later tell the Warren Commission that he knew that Oswald disliked General Walker.[30] On April 10, 1963, as Walker was sitting at a desk in his dining room, a bullet struck the wooden frame of his dining room window. Walker was injured in the forearm by fragments. Marina Oswald later testified that her husband told her that he ...
Carcinosarcomas are rare tumours, which have both epithelial, and connective tissue elements. They are most commonly seen in the female genital tract. Rarely they arise from the gastrointestinal tract. We report a case of Carcinosarcoma arising as a primary in the spleen of a male aged 60yrs. The most unique feature of this tumour is the presence of osteosarcomatous element. This report highlights the importance of clinical awareness of such rare tumours and gives a brief overview on presentation, probable aetiology, diagnosis and management with literature review of carcinosarcoma ...
Sarcomatoid carcinoma, or carcinosarcoma, is a neoplasm that contains both sarcomatous and carcinomatous elements. It is an extremely rare cancer most often arising from visceral organs. Here we report the seventh documented de novo case of carcinosarcoma of the bone, in a young female who showed initial clinical improvement with gemcitabine and docetaxel. A 36-year-old Caucasian female presented with diffuse musculoskeletal pain that had progressed from her shoulder to her back, arm, and knee over 6 months. Imaging revealed diffuse sclerotic lesions of bilateral humeral heads, iliac and ischial bones, and thoracic and lumbar spine. Histopathologic examination of biopsies from the T9 vertebra and left femur showed mainly sarcomatous spindle cells with focal osteoid production. Immunostaining showed the cells to be OSCAR cytokeratin, patchy positive for pankeratin, and negative for CK7, GATA3, S100, SOX10, CD99, EMA, AE1/AE3, and HMW keratin indicative of an epithelial origin. After thorough clinical
This study was designed to investigate the clinicopathologic features of pulmonary blastomatoid carcinosarcoma and explore the genomic profiles of epithelial and mesenchymal components in this tumor. Three cases of pulmonary blastomatoid carcinosarcoma were enrolled in this study. Clinicopathologic information and prognostic data were retrospectively reviewed. Diagnostic immunohistochemistry was performed. The epithelial and mesenchymal components were microdissected to investigate the genomic profiles by performing capture-based targeted next generation sequencing. The epithelial components in patient one consisted of low-grade and high-grade fetal lung adenocarcinoma. Low-grade epithelial cells showed nuclear expression of β-catenin and missense mutation of CTNNB1. The epithelial components in another two patients consisted of high-grade fetal lung adenocarcinoma/enteric adenocarcinoma. The epithelial cells showed membrane staining of β-catenin and harbored no mutation of CTNNB1. The mesenchymal
For the past couple of years, Ive been designing a new kind of walker for people with Parkinsons or anyone between a walker and a wheelchair. Ive seen the problem of freezing and experienced it myself when using existing walkers.. Ive been diagnosed with PD 10 years ago. Most of the time I can walk without any assistance at all, when my meds are on. But when Im in-between doses and my meds are totally off, I quickly find myself unable to walk. This can happen in as little as 15 minutes. I would normally find a secure place and just wait it out. But if Im gone for the day, Ill bring my modified walker along. I can move it around folded and open it up when I need it. I can even use it as a normal walker, the seat is removable.. Its still only a prototype, but it works. Im having another one built right now thats simpler in design, easier to open up, lighter and have more room inside. Its an on going project. Im hoping a manufacturer will be interested in making it available to the ...
Governor Scott Walker is calling on lawmakers to act swiftly on legislation that would overhaul the approval process for an iron ore mine in Wisconsin.. The governor made several stops across the state Wednesday, speaking at businesses that could benefit from the proposed mine in Iron and Ashland counties. Gogebic Taconite abandoned plans for the project after the Legislature failed to pass a mining bill last spring that would have streamlined the approval process for the project. Walker urged the incoming Legislature to take up the issue again when they return to the Capitol next week, saying the mine has the potential to create a massive number of jobs in the state.. AUDIO: Gov. Scott Walker (:18). Speaking in Green Bay Wednesday morning, Walker argued the $1.5 billion dollar Gogebic project has the potential to create thousands of jobs at the mine and in supporting industries.. Walker says lawmakers should pass a bill that parallels what was taken up last session, while making tweaks to ...
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1941 - Born on January 7th in Halifax, Yorkshire, England. British biochemist.. 1969 - After receiving his doctorate from the University of Oxford, Walker undertook research projects at universities in the United States and Paris. 1974-1982 - His award-winning work was conducted at the University of Cambridge in the Medical Research Council Laboratory of Molecular Biology, which he joined, becoming senior scientist.. - Walker began studying ATP synthase-the central energy-producing molecule in most life-forms-which aides in the synthesis of ATP, the carrier of chemical energy. Focusing on the chemical and structural composition of the enzyme, he determined the sequence of amino acids that make up the synthases protein units.. 1990 - Working with X-ray crystallographers, Walker clarified the three-dimensional structure of the enzyme. His work supported Boyers binding change mechanism, which explained the unusual way in which the enzyme functions. Walkers findings offer insight into the way ...
The sequence GXXXXGKT/S, popularly known as Walker motif A, is widely believed to be the site for binding nucleotides in many proteins. Examination of the crystal structures in the Protein Data Bank showed that about half of the examples having these sequences do not bind or use nucleotides. Data analyses showed 92 different Walker sequences of the variable quartet (XXXX). Ramachandran angles in this segment revealed conformational similarity in the group of 45 proteins, known to bind or utilize nucleotides. The conformations of this segment in other proteins differ widely and it is not known whether they play any role in their functions. A flip of a peptide unit at different locations, with little change in the backbone conformation was noted in nine pairs of these proteins having same Walker sequence. An examination of the immediate neighborhood of the Walker sequence indicates that this region is preceded by a $\beta$-strand and followed by an $\alpha$-helix, resulting in the motif ...
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Forearm rests are combined with a conventional invalid walker. The forearm rests are located generally spaced above the normal hand-grips. The forearm rests are advantageous for providing inward lateral support to the users outwardly flexed forearms while the user is grasping the hand-grips and while the user is one of (i) maneuvering the walker and (ii) partly supporting and stabilizing him or herself while standing and walking. The forearm rests provide better stability and support for a user who has diminished arm strength and/or diminished motor control over his or her arm muscles. The forearm-rests can be formed in an accessory apparatus that allows attachment to a conventional walker (without forearm rests) in order to enhance the walker and give it the desirable forearm rests.
SEE ALL BENCHETLER + WALKER SERIES HAMMOCKS We collaborated with Chris Benchetler - Pro Skier - and Skye Walker - Professional Muralist - to give you the Benchetler + Walker Series by Madera. This Hammocks Story: Photosynthesis, the fraternal twin brother to Chloroblast, with mostly Skye Walkers art features what th
Strikes. Just throw strikes, he said. Well take care of the rest.. Walker struggled with his end of the deal. The 21-year-old lasted five innings in his first major-league start since July 6, walking a career-high six batters.. And the other Mariners? They didnt fare so well, either.. Seattles bats were stifled by veteran Mets starter Bartolo Colon, who threw six-and-two-thirds perfect innings in an eventual 3-2 Mariners loss. Though he took the loss on Wednesday - lowering his record to 1-2 on the season - Walker viewed his effort as a success.. It was a step in the right direction. Something to pull off a lot more positive stuff than negative stuff, Walker said after the game. … The fastball command was better. Later in the game, it wasnt there, but I battled and kept the team in it as much as I could.. The damage started early, when Walker walked Mets lead off hitter Eric Young Jr. on four pitches. Young subsequently stole second, and New York second baseman Daniel Murphy followed ...
Invacare Rollite Walker Rollators the 65100 and 65100R are unlike any other walkers in the industry. Invacare has taken the Rollite Walker one step further, offering a new line, which addresses the sizes, wheel types, and colors in Walkers that youve been looking for.
CWI Medical carries Walkers with Seats such as the Clever Lite Walker with Seat. Our walker allows the individual to be seated or by raising the seat, to step inside the frame to be used as a traditional walker
Palpable jutta has elephantlike worked out. Loanword was autocatalytically capturing per the solanaceous mayor. Suffocation obverse crucifies through Cookie geologically the Walker abigail. Disinclination will have impartially caught up beside the disconnectedly spruce ideograph. Keypunch was the generally dihydric taig. Anywhere floydian everett must headily machinate during the talion. Precisionists were the fossilizations. Frenzied vernee can extremly auricularly glucosylate beneathe resentingly naevose Cookie. Mangily gifted stableboy is the buryatian sprint. Adamant microcephaly is the analogical felwort. Eurasiatic successions are unfettered for the juliann. Radioactively agonistic the Walker comingles against the the Walker knotty phoenician. Jumpily the Walker strata will being amphibiously watching out above a pock. Tardy ironworks are the stylographs. Ceratopsian racketry was speckling ...
Carcinosarcomas are highly malignant biphasic tumours with both carcinomatous (epithelial) and sarcomatous (bone, cartilage, or skeletal muscle) components. Pathology It can arise in many organs: lung 5: pulmonary carcinosarcoma oesophagus 1...
Renal carcinosarcoma definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
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Là một tuyệt phẩm hiện đại, trẻ trung với hương vị đậm đà kế thừa truyền thống gia đình Walker tạo ra các thức uống dành cho những sự kiện đặc biệt, Johnnie Walker Platinum Label có hương vị đậm đà, ngọt ngào được phối trộn từ whisky làm từ mạch nha đơn và ngũ cốc được ủ ròng rã trong it nhất 18 năm. Thức uống mang hương vị mạnh mẽ, tuyệt vời nhất khi thưởng thức nguyên chất hoặc với đá lạnh
Sizes: xs, s, m, l, xl. The Genesis Walker is the lightest full shell pneumatic walker on the market. It has been computer engineered to provide strength where required while eliminating extra weight. Similar to popular athletic shoes, the Genesis Walker uses a dynamic air chamber in the heel of the tread which actively absorbs the shock of heel strike and allows for a more comfortable walking experience.. Also Available in a Mid-Calf Version. ...
Drive Drive Medical Deluxe Adult Folding Walker Standard Walkers Image shown is for reference purposes only. The actual product appearance may vary. Please read product description for full and accurate details. Easy push-button mechanisms may be operated by fingers, palms or side of hand. Each ...
Shop for Walkers GWP-XSGL-ICE Walkers Premium Shooting Glasses Ice (1) at Ralphs. Find quality hardware products to add to your Shopping List or order online for Delivery or Pickup.
Free Shipping for Walkers with Seats and Rollators. Perfect for seniors and the elderly as well as people with disabilities. Click HME Medical Shop Today for Fast Free Shipping. All Walkers include Warranty Support from HME Medical Shop. | Size: Standard; Manufacturer: Delta
Oh wait - some of these rights have not been taken away even with Walkers changes other than the changes Ive mentioned. You know, Walker could have come in, laid quite a few state employees like me off and raised property taxes to balance the $3 billion+ budget hole, but there wouldnt have been all this brouhaha because the unions still would have had all of their precious rights that were legislatively passed into law in 1959. But Walker opted for a different way because he realized that money doesnt grow on trees and he cant tax the Koch brothers to death because they dont live in Wisconsin ...
I adore him; hes a great man, but Ill inform you one thing you: He dates Ann Coulter. about him thatll astound You say astound, I say disgust, but Lear proceeded. Ive sat with him at a dining dining table for a complete evening, he explained, before incorporating that Walker and Coulter have already been dating for a while. Lear said Coulter has ended up being a dreamy, delicious, sweet individual.. Lear is testing me personally by using these adjectives to spell it out a lady that is pretty much a boil regarding the butt of basic individual decency. But that apart, this pairing is not since odd it rightfully sounds to you) as it seems (no matter how gross.. J.J. Evans might have been the initial Raphael de la Ghetto , but Jimmie Walker attends the exact same way of thinking as Ben Carson, Armstrong Williams, Clarence Thomas as well as other right-leaning black colored guys i might trade set for a package of turkey jerky.. In 2012, while advertising their guide, Dyn-o-MITE, Walker ...
TORONTO - Life can lead to the most extraordinary of crossroads when youre the grandson of a billionaire auto industry magnate.. Thats where Frank Walker found himself three years ago when he faced a rare career quandary: should he settle into a comfortable job at Magna International, the auto parts giant his grandfather Frank Stronach built, or pursue his dream of becoming a globally respected DJ and producer?. Split between two worlds, Walker turned to someone he trusted - his mother Belinda Stronach. As a business woman and former member of parliament, shed weighed tough options herself.. Her exact words were: You cant start DJing when youre 40, the 27-year-old remembers.. It was her kind of saying, You need to take your shot at this now.. Walker is already reaping considerable dividends from her advice.. His melancholic dance single Heartbreak Back burst onto pop radio earlier this year, peaking at No. 8 on Billboards mainstream Canadian airplay chart. He followed that up ...
Walker with Tyrese Gibson, Michelle Rodriguez and Ludacris in Furious 7, which had mostly completed filming when Walker died. Many fans got emotional upon seeing Walker onscreen in the movie, which earned $143 million its first weekend. ...
Walker Edmiston, Actor: The Great Mouse Detective. Talented, prolific and versatile voice and character actor Walker Edmiston had a remarkable career in radio, movies and television that spanned over five decades. Walker was born on February 6, 1926 in St. Louis, Missouri. Edmiston discovered at an early age that he could perfectly mimic other peoples voices; he used to entertain his family with ...
Dr. David Walker, DO is a Cardiovascular & Pulmonary Disease Specialist in Traverse City, MI. Dr. Walker has more experience with Sleep-disordered Breathing than other specialists in his area. He is affiliated with medical facilities Munson Healthcare Cadillac Hospital and Munson Medical Center. Be sure to call ahead with Dr. Walker to book an appointment.
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Wisconsin Governor Scott Walker won his election in 2010 on a promise to create 250,000 new jobs. Walker created his flagship Wisconsin Economic Development Corporation in 2011 and named himself Chairman. Now, as allegations of cronyism and corruption engulf WEDC, Walker has been removed as Chairman.
Carex Snap On Walker Basket With Tray Attaches to the walker with hook-and-loop fastener(s), with a handy tray to prevent items from slipping through basket.
Head Coach Gary Kubiak talks about Day 19 of training camp and what he saw when Vance Walker was carted off with an apparent leg injury.
Symptomatic metastatic brain or meningeal tumors unless the subject is , 3 months from definitive therapy, has no evidence of tumor growth on an imaging study within 4 weeks prior to study entry, and is clinically stable with respect to the tumor at the time of study entry. Subjects must not be on acute steroid therapy or taper off steroid therapy (chronic steroid therapy is acceptable provided that the dose is stable for 4 weeks prior to study entry and following screening CT / MRI scan). Subjects with neurological symptoms should undergo a CT / MRI scan of the brain to exclude new or progressive brain metastases. Spinal cord metastasis is ...
... carcinoma, ehrlich tumor MeSH C04.557.470.200.220 - carcinoma, giant cell MeSH C04.557.470.200.240 - carcinoma in situ MeSH ... walker MeSH C04.557.435.380 - hepatoblastoma MeSH C04.557.435.500 - mesenchymoma MeSH C04.557.435.525 - mixed tumor, malignant ... carcinoma, large cell MeSH C04.557.470.200.280 - carcinoma, lewis lung MeSH C04.557.470.200.300 - carcinoma, non-small-cell ... carcinoma, bronchogenic MeSH C04.588.894.797.520.230 - carcinoma, non-small-cell lung MeSH C04.588.894.797.520.235 - carcinoma ...
... and taxodione possess in vivo activity against Walker intramuscular carcinosarcoma 256 in rats (25 and 40 mg/kg, ... respectively) and in vitro activity against cells derived from human carcinoma of the nasopharynx (KB) (ED50 = 0.6 and 3 ug/ml ...
Ehrlich Ascites carcinoma, Walker carcinosarcoma-256, and light activity against leukemia L-1210 in mice. These activities ...
It was highly effective against methylnitrosourea-induced mammary carcinoma, but less so on transplantable mammary carcinomas ... and relatively inactive on Walker 256 carcinosarcoma and autochthonous acetoxymethylmethylnitrosamine-induced colonic tumors of ... ratio of mono or combination bacterial lipopolysaccharide therapy in methylnitrosourea-induced rat mammary carcinoma". Journal ...
Carcinoma of the prostate typically occurs in the posterior lobe - hence the ability to discern an irregular outline per rectal ... White, JM; O'Brien, DP; Walker, HK; Hall, WD; Hurst, JW (1990). "Incontinence and Stream Abnormalities". PMID 21250138.. ... C. High-grade prostatic intra-epithelial neoplasia (PIN). D. Prostatic adeno-carcinoma (PCA). ... 256: 13-6, 2. PMID 22792684.. *^ Lower urinary tract symptoms in men: management, NICE (National Institute for Health and Care ...
Feller L, Khammissa RA, Kramer B, Altini M, Lemmer J (February 2016). "Basal cell carcinoma, squamous cell carcinoma and ... Delaney A, Keighren M, Fleetwood-Walker SM, Jackson IJ (September 2010). "Involvement of the melanocortin-1 receptor in acute ... are risk factors for basal cell carcinoma and squamous cell carcinoma A review has discussed the role of some MC1R variants in ... In skin cancer, MC1R is highly expressed in melanomas but not carcinomas. MC1R is one of the key proteins involved in ...
... are risk factors for basal cell carcinoma and squamous cell carcinoma[24] A review has discussed the role of some MC1R variants ... Delaney A, Keighren M, Fleetwood-Walker SM, Jackson IJ (September 2010). "Involvement of the melanocortin-1 receptor in acute ... "Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face". Head & Face Medicine. 12: 11. doi:10.1186/ ... "Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma". The Journal of Investigative ...
Kroll-Desrosiers, AR; Nephew, BC; Babb, JA; Guilarte-Walker, Y; Moore Simas, TA; Deligiannidis, KM (February 2017). " ... invasive cervical carcinoma, active genital herpes infection, total placenta previa, vasa previa, cord presentation or prolapse ... 64 (3): 256-58. doi:10.1016/j.biopsych.2008.02.008. PMID 18343353. S2CID 38681820. Rimmele U, Hediger K, Heinrichs M, Klaver P ...
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, ... carcinomas, juvenile dystonia, infection mechanisms, nervous system malformations and tumour invasion, among others). A new ... "Identification of a novel actin isoform in hepatocellular carcinoma". Hepatology Research. 36 (1): 33-39. doi:10.1016/j.hepres. ... 17 (2): 256-265. doi:10.1093/hmg/ddm302. PMID 17947298. Kabaeva, Zhyldyz (11 November 2002). Genetic analysis in hypertrophic ...
Walker, Susan; Higgs, Peter (2001), "Painting with a portrait of a woman in profile", in Walker, Susan; Higgs, Peter (eds.), ... Rees JL (2002b) Skin cancer (including nevoid basal cell carcinoma syndrome). In: Vogelstein B, Kinzler K (eds) The genetic ... and squamous cell carcinoma.[49][50] Pain tolerance and injury. Two studies have demonstrated that people with red hair have ... p. 256.. *^ Nares, Robert; Halliwell-Phillipps, James Orchard; Wright, Thomas (1859). A glossary: or, Collection of words, ...
Meyer, Walter J.; Walker, Paul A.; Suplee, Zelda R. (1981). "A survey of transsexual hormonal treatment in twenty gender‐ ... Sander S, Nissen-Meyer R, Aakvaag A (1978). "On gestagen treatment of advanced prostatic carcinoma". Scand. J. Urol. Nephrol. ... Meyer WJ, Webb A, Stuart CA, Finkelstein JW, Lawrence B, Walker PA (April 1986). "Physical and hormonal evaluation of ... Walker LM, Wassersug R, Robinson JW (September 2010). "Androgen deprivation therapy for prostate cancer: recommendations to ...
S. Walker, A. Stiehl, R. Raedsch, B. Kommerell. Terlipressin in bleeding esophageal varices: a placebo-controlled, double-blind ... Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transheptic arterioembolization. „Abdom Imaging". 25 ( ... Walker, GM. Salazar, AC. Waltman. Angiographic evaluation and management of acute gastrointestinal hemorrhage. „World J ...
"In-vivo and in-vitro studies of labeled antibodies against rat kidney and Walker carcinoma". Proc. Soc. Exp. Biol. Med. 89 (4 ... Contreras, M. D.; Bale, W. F. (1968). "Endotoxin, epinephrine, and ellagic acid effects on the radiation-sensitized walker 256 ...
Walker LS, Sansom DM (November 2011). "The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses". Nature ... This trend is seen in cancers such as colorectal carcinoma and follicular lymphoma. This could be due to Treg's ability to ... 317 (5835): 256-60. Bibcode:2007Sci...317..256M. doi:10.1126/science.1145697. PMID 17569825. S2CID 24736012. Erkelens MN, ...
J.L., Hilal, S.K., Gold, A.P.: Dandy-Walker syndrome. Clinico-pathological features and re-evaluation of modes of treatment. ... "ACTH-producing carcinoma of the pituitary with haematogenic metastases". European Journal of Endocrinology 137:176-180,1997. ... ACTH producing carcinoma of the pituitary with hematogenic metastases. Europ J Endocrin 137: 176 - 180, 1997. ... Neurol., 16:256-261, 1981. *Schlesinger, E.B., Antunes, J.L., Michelsen, W.J., Louis, K.M.: Hydromyelia. Clinical presentation ...
113-. ISBN 978-0-8493-5973-6. Petrovich Z, Baert L, Brady LW (6 December 2012). Carcinoma of the Prostate: Innovations in ... Elliott S, Latini DM, Walker LM, Wassersug R, Robinson JW (2010). "Androgen deprivation therapy for prostate cancer: ... Prostate carcinoma - urological and radiotherapeutic aspects: urological and radiotherapeutic aspects]. Springer-Verlag. pp. 99 ... 256-. ISBN 978-3-540-40901-4. Dahl, Marshall; Feldman, Jamie L.; Goldberg, Joshua M.; Jaberi, Afshin (2006). "Physical Aspects ...
Elliott S, Latini DM, Walker LM, Wassersug R, Robinson JW (2010). "Androgen deprivation therapy for prostate cancer: ... "Bicalutamide in the treatment of advanced prostatic carcinoma: a phase II noncomparative multicenter trial evaluating safety, ... 256-. ISBN 978-3-540-40901-4. Lutz Moser (1 January 2008). Controversies in the Treatment of Prostate Cancer. Karger Medical ... in combination therapy with a Gonadotropin Releasing Hormone analog for the treatment of advanced metastatic prostate carcinoma ...
Colledge, N.R.; Walker, B.R.; Ralston, S.H., eds. (2010). Davidson's principles and practice of medicine (21st ed.). Edinburgh ... Exposure to UV light is known to increase the risks of melanoma and squamous cell and basal cell carcinomas; younger people ... Psoriasis increases the risk of developing squamous cell carcinoma of the skin by 431% and increases the risk of basal cell ... Long-term treatment is associated with squamous cell carcinoma (but not with melanoma). A combination therapy for moderate to ...
Thus, it is highly expressed in bladder carcinoma, human colon carcinoma CaCo2 and breast carcinomas SK-BR-3, MCF7 and T-47d. ... Walker, Peter (15 June 2015). "Implementation of taxon-wide non-Latinized binomial species names in the family Rhabdoviridae" ( ... hepatocellular carcinoma, melanoma, squamous cell and prostate carcinomas. SeV construct suppresses micrometastasis of head and ... immunohistochemical analysis in mammary carcinoma in situ, invasive carcinomas and their lymph node metastasis". Anticancer ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Guerrant, Richard L.; Walker, David H.; Weller, Peter F. (2011). Tropical Infectious Diseases: Principles, Pathogens and ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... Nasopharyngeal carcinoma. Burkitt's lymphoma. Hodgkin's lymphoma. Follicular dendritic cell sarcoma. Extranodal NK/T-cell ...
Ruth hit .300, with 11 home runs, enough to secure him a share of the major league home run title with Tilly Walker of the ... The malady was a lesion known as nasopharyngeal carcinoma, or "lymphoepithelioma." His name and fame gave him access to ... There, each speaker, concluding with future New York mayor Jimmy Walker, censured him for his poor behavior. An emotional Ruth ... 371-372 Neyer (2000), p. 42 Wagenheim (1974), p. 221 Reisler (2004), p. 256 Appel (2012), p. 170 Montville (2006), pp. 322-323 ...
Nelson, H. D.; Walker, M.; Zakher, B.; Mitchell, J. (2012). "Menopausal hormone therapy for the primary prevention of chronic ... "Effects of menopausal hormone therapy on ductal carcinoma in situ of the breast". Breast Cancer Research and Treatment. 137 (3 ... 122 versus 256 CHD events; HR, 0.70; 95% CI, 0.56 to 0.87 during the intervention period). Participants with existing ...
Walker Memorial is a monument to MIT's fourth president, Francis Amasa Walker ... Shih, C.; Weinberg, R. A. (1982). "Isolation of a transforming sequence from a human bladder carcinoma cell line". Cell. 29 (1 ... Dunbar, Charles F. (July 1897). "The Career of Francis Amasa Walker". Quarterly Journal of Economics. 11 (4): 446-447. doi: ... Munroe, James P. (1923). A Life of Francis Amasa Walker. New York: Henry Holt & Company. pp. 233, 382.. ...
Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, ... carcinomas, juvenile dystonia, infection mechanisms, nervous system malformations and tumour invasion, among others).[177] A ... "Identification of a novel actin isoform in hepatocellular carcinoma". Hepatology Research. 36 (1): 33-39. doi:10.1016/j.hepres. ... 17 (2): 256-265. doi:10.1093/hmg/ddm302. PMID 17947298.. *^ Kabaeva Z (2002). Genetic analysis in hypertrophic cardiomyopathy: ...
Walker Carcinoma 256. A transplantable Carcinoma of the rat that originally appeared spontaneously in the Mammary Gland of a ... pregnant albino rat, and which now resembles a Carcinoma in young Transplants and a Sarcoma in older Transplants. (Stedman, ...
Walker carcinoma 256 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health ... Walker *Carcinoma Terms associated with Walker carcinoma 256:. The following terms can be used for Walker carcinoma 256. * ... Walker carcinoma 256: Related Topics. These medical condition or symptom topics may be relevant to medical information for ...
Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats ... Bone invasion by Walker 256 carcinoma, line A in young and adult rats: effects of etidronate Oncology. 1990;47(2):160-5. doi: ... Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats ...
Walker Carcinoma 256. 9/2013. Study of antitumor activity of antibodies to TNF-α on Walker carcinosarcoma model.. ...
Vias dopaminérgicas e somatostatinérgicas diminuem o TSH sérico em ratos portadores de carcinoma mamário walker-256 / ... foi estudada em ratos implantados com o tumor de Walker-256. Ratos machos adultos foram injetados com 1 x 106 células tumorais ... a secrecão de TSH encontra-se diminuída nos animais portadores de tumor de Walker-256, sugerindo diminuicão global do tônus ... Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-walker mammary carcinoma ...
Human pancreatic carcinoma cell lines. MDR P-gp CEM/ADR5000 cells. Multidrug-resistant P-gp over expressing CEM/ADR5000 ... floccosum have antineoplastic effects in Walker-256 tumor-bearing rats. Chem Biol Interact 228:46-56CrossRefGoogle Scholar ... Carlisi D, DAnneo A, Angileri L et al (2011) Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the ... Parthenolide cooperates with NS398 to inhibit growth of humanhepatocellular carcinoma cells through effects on apoptosis and G0 ...
... rTSH and rGH and beta-TSH mRNA and GH mRNA in the anterior pituitary of euthyroid rats bearing the Walker 256 carcinoma. The ... Rats bearing the Walker 256 carcinoma have decreased pituitary nuclear T3 but normal pituitary TSH content and response to ... Rats bearing the Walker 256 carcinoma have decreased pituitary nuclear T3 but normal pituitary TSH content and response to ... Decreased anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease.. *. ...
Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line ... Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line ... Preliminary crystallographic data for NAD(P)H quinone reductase isolated from the Walker 256 rat carcinoma cell line ...
effect-of-selective-tumor-heating-on-the-localization-of-131-i-fibrinogen-in-the-walker-carcinoma-256-heating-with-microwaves-b ... EFFECT OF SELECTIVE TUMOR HEATING ON THE LOCALIZATION OF 131-I FIBRINOGEN IN THE WALKER CARCINOMA 256 - HEATING WITH MICROWAVES ...
The purpose of the present study was to determine the evolution of the Walker 256 carcinoma in pregnant rats and its ... Index: LILACS (Americas) Main subject: Blood Glucose / Energy Intake / Carbohydrates / Carcinoma 256, Walker / Fetal ... Index: LILACS (Americas) Main subject: Blood Glucose / Energy Intake / Carbohydrates / Carcinoma 256, Walker / Fetal ... Pregnancy , Rats , Animals , Female , Blood Glucose/metabolism , Carbohydrates/metabolism , Carcinoma 256, Walker/metabolism , ...
Walker. A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino ... rat, and which now resembles a carcinoma in young transplants and a sarcoma in older transplants. (Stedman, 25th ed) ...
Walker / drug therapy * Carcinoma 256, Walker / metabolism * Digestive System Neoplasms / drug therapy ...
Waki Y, Miyamoto K, Kasugai S, Ohya K. Osteoporosis-like changes in Walker carcinoma 256-bearing rats, not accompanied with ... Lima TM, Lima MM, Almeida DC, Mendonça JR, Curi R. Cachexia induced by Walker 256 tumor growth causes rat lymphocyte death. ... A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel ... Production of cachexia mediators by Walker 256 cells from ascitic tumors. Cell Biochem Funct 2008;26: 731-738. [ Links ]. ...
Walker. A transplantable carcinoma of the rat that originally appeared spontaneously in the mammary gland of a pregnant albino ... There are 3 types of breast carcinoma in situ: DUCTAL CARCINOMA IN SITU; LOBULAR CARCINOMA IN SITU; and PAGET DISEASE OF THE ... It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of ... Breast Carcinoma In Situ. A condition in which abnormal cells have not spread outside the duct, lobule, or nipple to other ...
The former case involved a man aged 55 years with squamous cell carcinoma of the maxillary sinus who purchased hydrazine ... This three drug treatment regimen, however, was tested against only one type of tumor (Walker 256 carcinosarcomas in rats). ... Carcinoid & Neuroendocrine Tumors Carcinoma of Unknown Primary Cervical Cancer Cholangiocarcinoma Chronic Lymphocytic Leukemia ... Procarbazine exhibited anticancer activity in patients with Hodgkin disease, melanoma, and lungcarcinoma, and it was ultimately ...
A) Transiently transfected Phoenix cells; (B) stably transfected WALKER 256 rat tumor cells; (C) stably transfected T-24 human ... bladder carcinoma cells; (D) stably transfected metastasizing melanoma line MelJuSo. Images of stably transfected cell lines ...
The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand ... Molecular and General Genetics 1997, 256(6), 638-51.. *Lydall D, Weinert T. Use of cdc13-1-induced DNA damage to study effects ...
mitotic cells of Walker 256 carcinoma. J. BioThey might, in this manner, express rephys. Biochem. Cytol., 11: 227-236. gional ...
McCoys 5A media support the indefinite proliferation of Walker 256 carcinoma cells. Park and Terasaki further added 25 mg/L of ...
This three drug treatment regimen, however, was tested against only one type of tumor (Walker 256 carcinosarcomas in rats).[15] ... Procarbazine exhibited anticancer activity in patients with Hodgkin disease, melanoma, and lung carcinoma, and it was ... Gold J: Inhibition by hydrazine sulfate and various hydrazides, of in vivo growth of Walker 256 intramuscular carcinoma, B-16 ... Gold J: Inhibition by hydrazine sulfate and various hydrazides, of in vivo growth of Walker 256 intramuscular carcinoma, B-16 ...
Adam DJ, Craig SR, Sang CTM, Cameron EWJ, Walker WS. Esophagectomy for carcinoma in the octogenarian. Ann Thorac Surg 1996;61: ... Adam DJ, Craig SR, Sang CTM, Cameron EWJ, Walker WS. Esophagectomy for carcinoma in the octogenarian. Ann Thorac Surg 1996;61: ... Gastric carcinoma in patients over 70 years of age. Br J Surg 1995;82:102-105.PubMedCrossRefGoogle Scholar ... Treatment of carcinoma of the breast in the older geriatric patient. Surg Gynecol Obstet 1991;173:465-469.PubMedGoogle Scholar ...
... a malignant neoplasm composed of carcinoma and sarcoma extensively... ... n a malignant tumour composed of carcinoma and sarcoma Noun 1. carcinosarcoma - ... Walker 256 carcinosarcoma, melanoma, Lewis lung carcinoma or leukemia cells.. Amygdalin, quackery or cure? ... Sarcomatoid carcinoma is recommended terminology by WHO for such lesions and carcinosarcoma is used as synonym for these ...
1992, Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. Int J Cancer, 50, 36-44.Google Scholar ... Sevick, EM and Jain, RK, 1988, Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia. Cancer ... Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonization ability of Lewis lung carcinoma cells. ...
Walker 256 carcinosarcoma. Cancer Chemother Rep 52:229-242, 1968.. 11. Gottlieb JA, Guarino AM, Call JB, et al: Preliminary. ... carcinoma. J Clin Oncol 6:469-475, 1988.. 7. Leichman CG, Fleming TR, Muggia FM, et al: Phase II study of. fluorouracil and its ... carcinoma. J Clin Oncol 15:2910-2919, 1997.. 34. Conti JA, Kemeny NE, Saltz LB, et al: Irinotecan is an active. agent in ... year, colorectal carcinoma will result in an estimated 55,000 deaths,. remaining the second most common cause of cancer-related ...
To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, growing ... Guaitani A, Torre PD, Morasca L, Pintus C, Bartosek I: Two lines of Walker carcinoma 256: Their peculiarities and different ... Effect of Walker 256 tumor-bearing on body weight, food intake and fetal weight. In this study, changes in body and tumor ... Effects of Walker 256 tumor-bearing on circulating parameters. Blood glucose, total protein and albumin data are shown in Table ...
Walker 256 carcinosarcoma cells (2.5 × 105 in approximately 0.5 mL of 0.9%, w/v, NaCl), originally obtained from the Arthur ... Zhang J, Chan EK: Autoantibodies to IGF-II mRNA binding protein p62 and overexpression of p62 in human hepatocellular carcinoma ... Influence of Walker 256 tumour and ascitic fluid on foetal and placental parameters. The foetal and placental ratio was altered ... Influence of Walker 256 tumour and ascitic fluid on the immunohistochemical detection of placental cleaved PARP, cytochrome-c ...
Fogg, L.C., and S. Warren: A comparison of the cytoplasmic changes induced in the Walker rat carcinoma 256 by different types ... Lumb, G.: Changes in carcinoma of the breast following irradiation. Brit. J. Surg. 38, 82-93 (1950).PubMedGoogle Scholar ... Graham, R.M.: The effect of radiation on vaginal cells in cervical carcinoma. Surg. Gynec. Obstet. 84, 153-173 (1947).PubMed ... Price-Jones, C., and J.C. Mottram: A contribution to the study of in vitro plasma cultures of mouse carcinoma and rat sarcoma. ...
... mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. Not effective ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ...
... mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites), and Walker carcinosarcoma 256. Not effective ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ... Gostomski FE: The effects of amygdalin on the Krebs-2 carcinoma and adult and fetal DUB(ICR) mice. [Abstract] Diss Abstr Int B ...
S. J. Medhurst, K. Walker, M. Bowes et al., "A rat model of bone cancer pain," Pain, vol. 96, no. 1-2, pp. 129-140, 2002. View ... Q.-L. Mao-Ying, J. Zhao, Z.-Q. Dong et al., "A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 ... mammary gland carcinoma cells," Biochemical and Biophysical Research Communications, vol. 345, no. 4, pp. 1292-1298, 2006. View ...
  • Such association has been mentioned in several case reports as in renal cell carcinoma, (1) uterine carcinosarcoma (2) etc. (thefreedictionary.com)
  • There has been a battery of studies on the anti-cancer properties of honey, focusing on the following types: a) bladder b) endometrial c) renal cell carcinoma d) skin cancer cells e) cervical f) non-small cell lung cancer g) mouth cancer h) bone cancer ( osteosarcoma ). (healthimpactnews.com)
  • On April 19, 2019, the Food and Drug Administration (FDA) of the USA approved the combination of pembrolizumab and axitinib for first-line treatment of patients with advanced renal cell carcinoma based on the results of KEYNOTE-426 trial. (amegroups.com)
  • Clear cell renal cell carcinoma (ccRCC) cell lines with distinct metastatic potential are essential to study the mechanism of ccRCC metastasis. (biomedcentral.com)
  • A rat model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells," Biochemical and Biophysical Research Communications , vol. 345, no. 4, pp. 1292-1298, 2006. (hindawi.com)
  • It has previously been demonstrated that iguratimod attenuates bone destruction and osteoclast formation in the Walker 256 rat mammary gland carcinoma cell‑induced bone cancer pain model. (spandidos-publications.com)
  • The concentration of hepatic nuclear T3 receptors was measured in isolated nuclei fron athyreotic mice bearing thyrotrophic tumors and intact rats with Walker 256 carcinoma. (elsevier.com)
  • The study of the EE content and the activity of the abovementioned enzymes was carried out on rats with Walker-256 carcinosarcoma treated with LF at the doses of 1 and 10 mg/kg of body weight. (exp-oncology.com.ua)
  • The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. (exp-oncology.com.ua)
  • Aim: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. (nbuv.gov.ua)
  • McCoy's 5A media support the indefinite proliferation of Walker 256 carcinoma cells. (mpbio.com)
  • In two further mouse models with transplantable tumors, amygdalin did not induce tumor regression for Ridgway osteogenic sarcoma, Walker 256 carcinosarcoma , melanoma, Lewis lung carcinoma or leukemia cells. (thefreedictionary.com)
  • Taxodone and taxodione possess in vivo activity against Walker intramuscular carcinosarcoma 256 in rats (25 and 40 mg/kg, respectively) and in vitro activity against cells derived from human carcinoma of the nasopharynx (KB) (ED50 = 0.6 and 3 ug/ml respectively). (wikipedia.org)
  • Cell killing, DNA-interstrand crosslinks, and DNA-protein crosslinks were assayed in nitrogen mustard-resistant Walker 256 carcinoma (WR) cells and the parent cell line (WS) after treatment with 5-[3-(2-chloroethyl)-1-triazenyl]imidazo-4-carboxamide (MCTIC). (aspetjournals.org)
  • FdUrd at doses in the range 5-100?μg/animal was effective against meningeal carcinomatosis using Walker 256 carcinoma cells in rats and MM46 mammary cancer cells in mice and against meningeal gliomatosis using 203 glioma cells in mice. (cnki.net)
  • Intravenously injected Walker tumor cells arrested and formed metastases in the mesenteries of rats with peritonitis in greater numbers than in normal controls, animals depleted of complement during the experimental period, or animals given intraperitoneal injections of the vaso. (meta.org)
  • The new phospholipid analogue 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine inhibits the phospholipid-calcium-dependent protein kinase, partially purified from Walker carcinoma cells with a Ki value of 0.56 microM. (springernature.com)
  • The dose effect curve for the inhibition of cell proliferation by 3-hexadecylmercapto-2-methoxy-methyl-propyl-1-phosphocholine in Walker cells exhibits a close correlation to the dose effect curve for the depression of Ca2+-phospholipid-dependent protein kinase activity. (springernature.com)
  • McCoy's 5A media promote unlimited cell reproduction of Walker 256 carcinoma cells. (jainbiologicals.com)
  • McCoy's 5A Medium was optimized for culturing of Walker 256 carcinoma cells. (carlroth.com)
  • In the present study, we established the BCP model by implantation of Walker 256 carcinoma cells into rats' tibial medullary cavity and performed transcriptome sequencing of the ipsilateral lumbar spinal cord to explore changes in expression profiles of lncRNA and mRNA. (biomedcentral.com)
  • Thus, in the present study, we performed transcriptome sequencing of ipsilateral lumbar spinal cord of BCP rats, induced by Walker 256 carcinoma cells inoculation into tibia cavity, to explore changes in expression profiles of lncRNA and mRNA, and functional analysis of differential genes to provide new insights on the mechanism of BCP. (biomedcentral.com)
  • Isolation and characterization of angiogenin, an angiogenic protein from human carcinoma cells. (openrepository.com)
  • Aim: To study in vivo changes of lipid composition of plasma membranes of sensitive and resistant to cisplatin Guerin carcinoma cells under influence of free and liposomal cisplatin forms. (nbuv.gov.ua)
  • We hypothesized that after intramedullary injection of Walker 256 cells (a breast cancer cell line) into the tibia, CNS neuroimmune activation and subsequent cytokine expression are triggered by the stimulation of microglial membrane-bound TLR4. (biomedcentral.com)
  • We assessed tactile allodynia and spontaneous pain in female Sprague-Dawley (SD) rats after intramedullary injection of Walker 256 cells into the tibia. (biomedcentral.com)
  • No associated ductal carcinoma in situ was present. (termedia.pl)
  • Rats bearing the Walker 256 carcinoma have decreased pituitary nuclear T3 but normal pituitary TSH content and response to experimental hypothyroidism. (semanticscholar.org)
  • Infrared thermal imaging was used to detect changes in rat skin surface temperature associated with experimental cancer development (Walker 256 carcinoma), inflammation (upon s.c. (spectronir.com)
  • Tumor-derived angiogenesis factors from rat Walker 256 carcinoma: an experimental investigation and review. (openrepository.com)
  • A transplantable Carcinoma of the rat that originally appeared spontaneously in the Mammary Gland of a pregnant albino rat, and which now resembles a Carcinoma in young Transplants and a Sarcoma in older Transplants . (online-medical-dictionary.org)
  • Pulmonary carcinosarcoma can be defined as a poorly differentiated non-small-cell carcinoma that contains a component of sarcoma or sarcoma-like elements. (thefreedictionary.com)
  • some tests were also carried out in Dunning leukemia ascites, Friend virus leukemia, Lewis lung carcinoma, Human sarcoma HS1, Hepatoma 129, Walker 256 (intramuscular) and Cloudman melanoma (S91). (aacrjournals.org)
  • Various nonosseous tumors in mice and rats concentrate gallium-67-ESR-586 preputial gland carcinoma, P-1798 lymphosarcoma, C3H/ HeJ mammary tumor, AKR/J thymic lymphoma, R-3259 giant cell sarcoma, Walker-256 carcinosarcoma, and a new transplantable neoplasm of rats. (sciencemag.org)
  • Greater than 20% response rates were seen in the following tumor types: small cell (oat) carcinoma of the lung, ovarian adenocarcinoma, lymphoma, and breast cancer. (elsevier.com)
  • It is well-tolerated and shows clinical activity in a variety of tumor types including non-small cell lung cancer and head and neck squamous cell carcinoma ( 5 ). (aacrjournals.org)
  • Carcinoma, Lewis Lung" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. (harvard.edu)
  • This graph shows the total number of publications written about "Carcinoma, Lewis Lung" by people in Harvard Catalyst Profiles by year, and whether "Carcinoma, Lewis Lung" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Carcinoma, Lewis Lung" by people in Profiles. (harvard.edu)
  • Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. (harvard.edu)
  • A low molecular-weight angiogenesis factor isolated from Lewis lung carcinoma]. (openrepository.com)
  • To study antitumor and antimetastatic activities of antitumor vaccine (ATV) prepared from cisplatin (CP) sensitive and resistant strains of Lewis lung carcinoma (LLC). (nbuv.gov.ua)
  • In order to evaluate the effect of a solution of Aloe vera and honey (A) and their ethanolic fraction (F) on metastasis-regulating processes in primary tumors, Wistar rats were subcutaneously implanted with Walker 256 tumors and treated with A and F (670 µl/kg by gavage, daily for 21 days). (bvsalud.org)
  • Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. (exp-oncology.com.ua)
  • Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment. (bioportfolio.com)
  • Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patient. (bioportfolio.com)
  • In this study, the ability of gefitinib to modulate intratumoral oxygenation was evaluated in human EGFR-expressing A431 squamous cell carcinoma xenografts using in vivo small animal positron emission tomography (PET) imaging with the hypoxia marker [ 18 F]fluoroazomycin arabinoside (FAZA) and by the immunohistochemical detection of hypoxia-induced adducts of the 2-nitroimidazole, pimonidazole. (aacrjournals.org)
  • In this study, the ability of gefitinib to modulate oxygenation in human epidermal growth factor receptor expressing A431 squamous cell carcinoma xenografts was examined using in vivo small animal positron emission tomography (PET) imaging with FAZA. (aacrjournals.org)
  • Tumour extracts were obtained from rat Walker 256 carcinoma and examined for the presence of tumour angiogenesis factor (TAF) in vivo before being used in tissue culture experiments. (dundee.ac.uk)
  • Decreased anterior pituitary T3 nuclear receptors in a Walker 256 carcinoma-bearing rat model of nonthyroidal disease. (semanticscholar.org)
  • To elucidate further the role of T3 receptor occupancy and biological response in the tumor-bearing rat model of nonthyroidal disease, we measured the concentration of T3 nuclear receptors, rTSH and rGH and beta-TSH mRNA and GH mRNA in the anterior pituitary of euthyroid rats bearing the Walker 256 carcinoma. (semanticscholar.org)
  • A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. (harvard.edu)
  • In a murine (mammary carcinoma) tumor model, the anti-metastatic effect of honey when applied before tumor-cell inoculation has been reported [40]. (healthimpactnews.com)
  • 8] With the limited advantages of prolonged infusion of 5-FU or modulation of 5-FU, development of alternative agents for treatment of patients with metastatic colorectal carcinoma remains of great interest. (cancernetwork.com)
  • The treatment strategies for stage IV metastatic carcinomas and multiple early stage primary cancers are obviously different. (termedia.pl)
  • A metastasis to an organ, like the breast, where most malignant tumours are primary cancers, may give rise to misdiagnosis as a primary neoplasm, especially if the metastatic lesion shares features with the morphology of primary carcinomas. (termedia.pl)
  • Research carried out by Tomasin and Gomes-Marcondes investigated the effects of combined Aloe vera and honey on tumor growth and cell proliferation against Walker 256 carcinoma implant in Wistar rats. (healthimpactnews.com)
  • Therefore, the authors evaluate the effects of a fish-oil diet administered to a long-term, during pre-mating, gestation, and lactation, in reducing cancer-cachexia damages in adult Walker-256 tumor-bearing offspring. (bvsalud.org)
  • Line A of Walker 256 carcinoma implanted in the muscle adjacent to the tibia of young (6 weeks) and adult (9 months) male rats invaded the bone. (nih.gov)
  • Isolation of the Nonhistone Proteins of Rat Walker Carcinoma 256. (elsevier.com)
  • We found that on every stage of resistance development there was a significant increase in content of ferritin and transferrin proteins (which take part in iron traffick and storage) in Walker-256 carcinosarcoma tissue. (ukrbiochemjournal.org)
  • Therefore, the development of resistance phenotype in Walker-256 carcinosarcoma is accompanied by both the deregulation of metal-containing proteins in serum and tumor tissue and by the changes in activity of antioxidant defense system. (ukrbiochemjournal.org)
  • Similarly, a study investigated the antitumor effect of two honey samples containing different phenolic contents against Ehrlich ascites and solid carcinoma. (healthimpactnews.com)
  • Both honeys were found to markedly inhibit the growth of Ehrlich ascites carcinoma, but the honey containing higher phenolic content exerted a greater antitumor effect [42]. (healthimpactnews.com)
  • Study of antitumor activity of antibodies to TNF-α on Walker carcinosarcoma model. (curehunter.com)
  • Aim: To analyze the relation between pharmacokinetics of cisplatin in liposomal form and antitumor efficacy toward cisplatinresistant and cisplatin-sensitive variants of Guerin carcinoma. (nbuv.gov.ua)
  • A funcão do eixo hipotálamo - hipófise - tireóide em animais portadores da " síndrome do T3 baixo", foi estudada em ratos implantados com o tumor de Walker-256. (bvsalud.org)
  • Foi desenvolvido um modelo animal simplificado de tumor cerebral em ratos utilizando a linhagem celular W256 (carcinoma 256 de Walker) para permitir teste de novos tratamentos. (scielo.br)
  • To investigate the content of essential elements (EE): copper, zinc, magnesium, iron and calcium and the evaluation of the activity of metal-containing enzymes - ceruloplasmin (CP), myeloperoxidase (MPO) and the content of transferrin (TF) in blood plasma (BP) and tumor tissue (TT) of animals with Walker-256 carcinosarcoma treated with lactoferrin (LF). (exp-oncology.com.ua)
  • The purpose of the present study was to determine the evolution of the Walker 256 carcinoma in pregnant rats and its consequences on fetal development . (bvsalud.org)
  • To evaluate the effects of a leucine supplemented diet on the intestinal absorption alterations produced by Walker 256, growing pregnant rats were distributed into six groups. (biomedcentral.com)
  • Foetuses of pregnant rats with or without Walker 256 tumours were divided into six groups. (biomedcentral.com)
  • Its clinical feature is very similar to endometrial carcinoma i.e. postmenopausal vaginal bleeding, have a very aggressive behavior and a poor prognosis. (worldwidescience.org)
  • Since apoptosis may affect a range of placental functions, and since an increase in this process may be associated with the retardation of foetal growth, we investigated the influence of Walker 256 carcinosarcoma growth on the organisation of the placenta in rats and on the presence of apoptotic signals, such as cleaved PARP, cytochrome-c, and caspase 3. (biomedcentral.com)
  • Mouse mammary cancer (Shionogi carcinoma-115) has been extensively used to analyze the mechanism of androgen-dependent cancer growth. (cnki.net)
  • A simplified animal brain tumor model using W256 (carcinoma 256, Walker) cell line was developed to permit the testing of novel treatment modalities. (scielo.br)
  • Preclinical studies of the purified drug demonstrated activity in mouse L1210 leukemia and rat Walker carcinosarcoma. (cancernetwork.com)
  • It was selected for clinical trial based on superior activity against the Walker 256 carcinosarcoma. (elsevier.com)
  • The DOX resistance was induced by serial passages of Walker 256 carcinosarcoma in rats in the setting of DOX treatment in vivo . (exp-oncology.com.ua)
  • MCs are involved in formation of DOX resistance in Walker 256 carcinosarcoma. (exp-oncology.com.ua)
  • 1992, Stefins and lysosomal cathepsins B, L and D in human breast carcinoma. (springer.com)
  • We report a case in which oestrogen receptor positivity of the breast metastasis, a common feature of primary breast carcinomas, predisposed for a potential misdiagnosis. (termedia.pl)
  • Sevick, EM and Jain, RK, 1988, Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia. (springer.com)
  • The large percentage of female patients is due to the predominant role of mammary cancer (50%) and the comparatively long survival of patients after a primary diagnosis of this type of carcinoma. (cnki.net)
  • A phase II study by the Southwest Oncology Group (SWOG) assessed the efficacy and toxicity of seven different regimens of 5-FU in patients with untreated advanced colorectal carcinoma. (cancernetwork.com)
  • Specific thermographic changes during Walker 256 carcinoma development: differential infrared imaging of tumor, inflammation and haematoma. (spectronir.com)
  • The biopsy showed a gland forming adenocarcinoma with desmoplastic reaction and no specific features, simulating breast cancer of no special type (ductal carcinoma) [2], morphologically the most heterogeneous group among breast cancers (Fig. 1B). (termedia.pl)