A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the LIVER.
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma.
Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)
A malignant epithelial tumor with a glandular organization.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the NASOPHARYNX.
A cell line derived from cultured tumor cells.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Tumors or cancer of the THYROID GLAND.
Tumors or cancer of the human BREAST.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Tumors or cancer of the LUNG.
A tumor of both low- and high-grade malignancy. The low-grade grow slowly, appear in any age group, and are readily cured by excision. The high-grade behave aggressively, widely infiltrate the salivary gland and produce lymph node and distant metastases. Mucoepidermoid carcinomas account for about 21% of the malignant tumors of the parotid gland and 10% of the sublingual gland. They are the most common malignant tumor of the parotid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575; Holland et al., Cancer Medicine, 3d ed, p1240)
A mixed adenocarcinoma and squamous cell or epidermoid carcinoma.
An adenocarcinoma characterized by the presence of cells resembling the glandular cells of the ENDOMETRIUM. It is a common histological type of ovarian CARCINOMA and ENDOMETRIAL CARCINOMA. There is a high frequency of co-occurrence of this form of adenocarcinoma in both tissues.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
A highly malignant, primitive form of carcinoma, probably of germinal cell or teratomatous derivation, usually arising in a gonad and rarely in other sites. It is rare in the female ovary, but in the male it accounts for 20% of all testicular tumors. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, p1595)
Tumors or cancer of the ESOPHAGUS.
Tumors or cancer of the MOUTH.
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Malignant neoplasms involving the ductal systems of any of a number of organs, such as the MAMMARY GLANDS, the PANCREAS, the PROSTATE, or the LACRIMAL GLAND.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Tumors or cancer of the COLON.
A variant of well-differentiated epidermoid carcinoma that is most common in the oral cavity, but also occurs in the larynx, nasal cavity, esophagus, penis, anorectal region, vulva, vagina, uterine cervix, and skin, especially on the sole of the foot. Most intraoral cases occur in elderly male abusers of smokeless tobacco. The treatment is surgical resection. Radiotherapy is not indicated, as up to 30% treated with radiation become highly aggressive within six months. (Segen, Dictionary of Modern Medicine, 1992)
A poorly differentiated adenocarcinoma in which the nucleus is pressed to one side by a cytoplasmic droplet of mucus. It usually arises in the gastrointestinal system.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Tumors or cancer of the URINARY BLADDER.
Tumors or cancer of the STOMACH.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the SKIN.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
DNA present in neoplastic tissue.
Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Tumors or cancer of the UTERINE CERVIX.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An adenocarcinoma of the thyroid gland, in which the cells are arranged in the form of follicles. (From Dorland, 27th ed)
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The malignant stem cells of TERATOCARCINOMAS, which resemble pluripotent stem cells of the BLASTOCYST INNER CELL MASS. The EC cells can be grown in vitro, and experimentally induced to differentiate. They are used as a model system for studying early embryonic cell differentiation.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
A thyroid neoplasm of mixed papillary and follicular arrangement. Its biological behavior and prognosis is the same as that of a papillary adenocarcinoma of the thyroid. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1271)
Tumors or cancer of the gallbladder.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
An adenocarcinoma characterized by the presence of varying combinations of clear and hobnail-shaped tumor cells. There are three predominant patterns described as tubulocystic, solid, and papillary. These tumors, usually located in the female reproductive organs, have been seen more frequently in young women since 1970 as a result of the association with intrauterine exposure to diethylstilbestrol. (From Holland et al., Cancer Medicine, 3d ed)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Tumors or cancer of the TONGUE.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A malignant cystic or semicystic neoplasm. It often occurs in the ovary and usually bilaterally. The external surface is usually covered with papillary excrescences. Microscopically, the papillary patterns are predominantly epithelial overgrowths with differentiated and undifferentiated papillary serous cystadenocarcinoma cells. Psammoma bodies may be present. The tumor generally adheres to surrounding structures and produces ascites. (From Hughes, Obstetric-Gynecologic Terminology, 1972, p185)
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Tumors or cancer of the BRONCHI.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Tumors or cancer of the SALIVARY GLANDS.
The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Elements of limited time intervals, contributing to particular results or situations.
RNA present in neoplastic tissue.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Transplantation between animals of different species.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Antibodies produced by a single clone of cells.
A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
Administration of antineoplastic agents together with an embolizing vehicle. This allows slow release of the agent as well as obstruction of the blood supply to the neoplasm.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Tumors or cancer of the RECTUM.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Experimentally induced tumors of the LIVER.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Tumors or cancers of the ADRENAL CORTEX.
The epithelial lining of the URINARY TRACT.
Tumors or cancer of the VULVA.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Tumors or cancer of the OROPHARYNX.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Compounds that include the amino-N-phenylamide structure.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Methods which attempt to express in replicable terms the level of CELL DIFFERENTIATION in neoplasms as increasing ANAPLASIA correlates with the aggressiveness of the neoplasm.
Tumors or cancer of the BILE DUCTS.
An epithelial neoplasm characterized by unusually large anaplastic cells. It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. It is most common in the lung and thyroid. (From Stedman, 25th ed & Segen, Dictionary of Modern Medicine, 1992)
Tumors or cancer of the URINARY TRACT in either the male or the female.
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
Established cell cultures that have the potential to propagate indefinitely.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Organic salts and esters of benzenesulfonic acid.
Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
Biochemical identification of mutational changes in a nucleotide sequence.
Excision of all or part of the liver. (Dorland, 28th ed)
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Excision of kidney.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
A usually benign glandular tumor composed of oxyphil cells, large cells with small irregular nuclei and dense acidophilic granules due to the presence of abundant MITOCHONDRIA. Oxyphil cells, also known as oncocytes, are found in oncocytomas of the kidney, salivary glands, and endocrine glands. In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.
A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
An adenocarcinoma with a hard (Greek skirrhos, hard) structure owing to the formation of dense connective tissue in the stroma. (From Dorland, 27th ed)
Tumors of cancer of the EYELIDS.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
An adenocarcinoma in which the tumor elements are arranged as finger-like processes or as a solid spherical nodule projecting from an epithelial surface.
A dilation of the duodenal papilla that is the opening of the juncture of the COMMON BILE DUCT and the MAIN PANCREATIC DUCT, also known as the hepatopancreatic ampulla.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Neoplasms of the SQUAMOUS EPITHELIAL CELLS. The concept does not refer to neoplasms located in tissue composed of squamous elements.
A malignant tumor of the skin appendages, which include the hair, nails, sebaceous glands, sweat glands, and the mammary glands. (From Dorland, 27th ed)
Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Tumors or cancer of the PHARYNX.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Tumors or cancer of the HYPOPHARYNX.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.

Immune responses to all ErbB family receptors detectable in serum of cancer patients. (1/8912)

Employing NIH3T3 transfectants with individual human ErbB receptor coding sequences as recombinant antigen sources, we detected by immunoblot analysis specific immunoreactivity against all four ErbB receptors among 13 of 41 sera obtained from patients with different types of epithelial malignancies. Overall, serum positivity was most frequently directed against ErbB2 followed by EGFR, ErbB3 and ErbB4. Specificity patterns comprised tumor patients with unique serum reactivity against ErbB2 or ErbB4. Moreover, approximately half of the positive sera exhibited concomitant reactivity with multiple ErbB receptors including EGFR and ErbB2, EGFR and ErbB4, ErbB2 and ErbB3 or EGFR, ErbB2 and ErbB3. Serum reactivity was confirmed for the respective ErbB receptors expressed by human tumor cells and corroborated on receptor-specific immunoprecipitates. Positive sera contained ErbB-specific antibodies of the IgG isotype. Representative immunohistochemical analysis of tumor tissues suggested overexpression of ErbB receptors for which serum antibodies were detectable in five of six patients. These findings implicate multiple ErbB receptors including ErbB3 and ErbB4 in addition to EGFR and ErbB2 in primary human cancer. Heterogeneity of natural ErbB-specific responses in cancer patients warrants their evaluation in light of immunotherapeutic approaches targeting these receptors.  (+info)

Development of a sensitive, specific reverse transcriptase polymerase chain reaction-based assay for epithelial tumour cells in effusions. (2/8912)

We developed a sensitive and specific method for the detection of epithelial cancer cells in effusions with a two-stage molecular-based assay which combined enrichment for cancer cells by immunomagnetic bead selection and reverse transcriptase polymerase chain reaction (RT-PCR) detection of epithelial glycoprotein 2 (EGP-2) RNA. Preliminary experiments indicated that immunobead selection was essential to avoid occasional false-positive RT-PCR results, and this method detected ten breast cancer cells electively added to 10(7) cytologically negative effusion cells. We studied 110 cases of pleural (n = 68) and peritoneal (n = 42) effusions (30 from patients with known carcinoma and 80 from those without known carcinoma), and the results were compared with cytological findings. Of 18 effusions that were cytologically positive or suspicious for malignant cells, 17 (94%) were positive for EGP-2 RNA (the one negative sample was from a patient who recently received combination chemotherapy). Of 92 cytologically negative samples, 11 (12%) were positive for EGP-2, including six patients with a history of previous or current carcinoma. Our method appears to be highly specific and increases the sensitivity of detection of malignant cells; it may be a useful adjunct to routine cytopathological examination.  (+info)

Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. (3/8912)

Expression of CDX2, a caudal-related homeobox gene, was found to be decreased in colorectal carcinomas. Heterozygous null mutant mice as to Cdx2 develop multiple intestinal adenomatous polyps. To clarify the role of CDX2 in colorectal carcinogenesis, we determined its genomic structure, and searched for mutations of CDX2 in 49 sporadic colorectal carcinomas and ten hereditary non-polyposis colorectal cancers (HNPCC) without microsatellite instability. None of them exhibited a mutation. We further examined 19 HNPCC carcinomas with microsatellite instability for mutations in a (G)7 repeat site within CDX2. One of them (5.3%) exhibited one G insertion. Loss of heterozygosity was observed in 2 of the 20 (10%) informative sporadic carcinomas, and in one of the three (33.3%) informative HNPCC cancers. These data indicate that CDX2 may play only a minor role in colorectal carcinogenesis.  (+info)

Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers. (4/8912)

Carcinoma of the uterine cervix is a common malignancy among women that has been found to show loss of heterozygosity in the chromosome 11p. Recent studies have localized the TSG101 gene in this region, and also demonstrated a high frequency of abnormalities of this gene in human breast cancer. To determine the role of the TSG101 gene in the carcinogenesis of cervical and uterine carcinoma, 19 cases of cervical carcinoma and five cases of endometrial carcinoma, as well as nearby non-cancerous tissue from the same patients, and 16 blood samples from healthy persons as normal control were analysed by Southern blot analysis of genomic DNA, reverse transcription of the TSG101 mRNA followed by PCR amplification and sequencing of the products. We found that abnormal transcripts of the TSG101 gene were common both in cancerous or non-cancerous tissues of the uterus and cervix and in normal peripheral mononuclear cells. There was no genomic deletion or rearrangement in spite of the presence of abnormal transcripts, and no definite relationship between the abnormal transcripts and HPV infection was found. Although the frequency of abnormal transcripts was higher in cancerous than in non-cancerous tissue, normal peripheral mononuclear cells also had abnormal transcripts. Given these findings, the role of the TSG101 gene as a tumour-suppressor gene should be re-evaluated. Because some aberrant transcripts could be found at the first PCR reaction, we suggest that the aberrant transcripts might be the result of imperfect minor splicesome products.  (+info)

Intensive weekly chemotherapy is not effective in advanced pancreatic cancer patients: a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD). (5/8912)

Twenty-two patients, with locally advanced unresectable and/or metastatic pancreatic carcinoma, received weekly administration of cisplatin 40 mg m(-2), 5-fluorouracil 500 mg m(-2), epidoxorubicin 35 mg m(-2), 6S stereoisomer of leucovorin 250 mg m(-2) and glutathione 1.5 mg m(-2), supported by a daily administration of lenograstim at a dose of 5 microg kg(-1). Nineteen patients were men and three were women. Median age was 63 years (range 47-70). At study entry, pain was present in 15 out of 22 patients (68%) with a mean value of Scott-Huskisson scale of 27.6+/-23.8, whereas a weight loss >10% was present in 15 patients. After eight weekly treatments, three partial responses were achieved for a response rate of 13% (95% CI 0-26%), five patients had stable disease and 14 progressed on therapy. Pain was present in 9 out of 22 patients (40%) with a mean value of Scott-Huskisson scale of 12.3+/-18.4. Eight patients (36%) (three partial response and five stable disease) had a positive weight change. Toxicity was mild: WHO grade III or IV toxicity was recorded in terms of anaemia in 7 out of 188 cycles (3.7%), of neutropenia in 9 out of 188 cycles (4.7%) and of thrombocytopenia in 3 out of 188 cycles (1.5%). Median survival of all patients was 6 months. The outcome of this intensive chemotherapy regimen does not support its use in pancreatic cancer.  (+info)

Peritoneal cytology in the surgical evaluation of gastric carcinoma. (6/8912)

Many patients undergoing surgery for gastric carcinoma will develop peritoneal metastases. A method to identify those patients at risk of peritoneal recurrence would help in the selection of patients for adjuvant therapy. Peritoneal cytology has received little attention in the West, but may prove a useful additional means of evaluating patients with gastric cancer. The aims of this study were to evaluate sampling techniques for peritoneal cytology in patients with gastric cancer, to assess the prognostic significance of free peritoneal malignant cells and to discover the effect of the operative procedure on dissemination of malignant cells. The study is based on 85 consecutive patients undergoing surgical treatment of gastric cancer and followed up for 2 years or until death. Peritoneal cytology samples were collected at laparoscopy, and at operation prior to resection by intraperitoneal lavage and serosal brushings. After resection, samples were taken by peritoneal lavage, imprint cytology of the resected specimen and post-operatively by peritoneal irrigation via a percutaneous catheter. Malignant cells were diagnosed by two independent microscopists. Preoperative peritoneal lavage yielded malignant cells in 16 out of 85 cases (19%). The yield of free malignant cells was increased by using serosal brushings (by four cases) and imprint cytology (by two cases); all of the cases had evidence of serosal penetration. One serosa-negative case exhibited positive cytology in the post-resection peritoneal specimen in which the preresection cytology specimen was negative. Survival was worse in the cytology-positive group (chi2 = 25.1; P< 0.0001). Among serosa-positive patients, survival was significantly reduced if cytology was positive, if cases yielded by brushings and imprint cytology were included (log-rank test = 8.44; 1 df, P = 0.004). In conclusion, free peritoneal malignant cells can be identified in patients with gastric cancer who have a poor prognosis; the yield can be increased with brushings and imprint cytology in addition to conventional peritoneal lavage. Evaluation of peritoneal cytology by these methods may have a role in the selection of patients with the poorest prognosis who may benefit most from adjuvant therapy.  (+info)

Loss of heterozygosity (LOH), malignancy grade and clonality in microdissected prostate cancer. (7/8912)

The aim of the present study was to find out whether increasing malignancy of prostate carcinoma correlates with an overall increase of loss of heterozygosity (LOH), and whether LOH typing of microdissected tumour areas can help to distinguish between multifocal or clonal tumour development. In 47 carcinomas analysed at 25 chromosomal loci, the overall LOH rate was found to be significantly lower in grade 1 areas (2.2%) compared with grade 2 (9.4%) and grade 3 areas (8.3%, P = 0.007). A similar tendency was found for the mean fractional allele loss (FAL, 0.043 for grade 1, 0.2 for grade 2 and 0.23 for grade 3, P = 0.0004). Of 20 tumours (65%) with LOH in several microdissected areas, 13 had identical losses at 1-4 loci within two or three areas, suggesting clonal development of these areas. Markers near RB, DCC, BBC1, TP53 and at D13S325 (13q21-22) showed higher loss rates in grades 2 and 3 (between 25% and 44.4%) compared with grade 1 (0-6.6%). Tumour-suppressor genes (TSGs) near these loci might, thus, be important for tumour progression. TP53 mutations were detected in 27%, but BBC1 mutations in only 7%, of samples with LOH. Evaluation of all 25 loci in every tumour made evident that each prostate cancer has its own pattern of allelic losses.  (+info)

Expression of pyrimidine nucleoside phosphorylase mRNA plays an important role in the prognosis of patients with oesophageal cancer. (8/8912)

To clarify the significance of the expression of pyrimidine nucleoside phosphorylase (PyNPase) mRNA as a predictive factor for the prognosis of patients with oesophageal carcinoma, the PyNPase mRNA in the tumours and normal tissues from 55 resected cases of oesophageal carcinoma was examined by a reverse transcription polymerase chain reaction (RT-PCR). As a result, a positive correlation was observed between the tumour/normal (T/N) ratio of the expression of PyNPase mRNA by RT-PCR and that of the enzyme activity of PyNPase based on the findings of an enzyme linked immunosolvent assay (r = 0.594, P = 0.009). The T/N ratio of the expression of PyNPase mRNA was significantly higher in the cases with lymph vessel invasion (P = 0.013), lymph node metastasis (P = 0.0016), and an advanced stage of the disease (P = 0.021) than those without these factors. The patients with a higher T/N ratio of PyNPase mRNA showed significantly worse prognosis than those with a lower T/N ratio (P = 0.023 with log-rank tests). A multivariate analysis for the cumulative survival rates revealed that a high T/N ratio of the expression of PyNPase mRNA was independently related to a poor prognosis. These findings suggested that the determination of PyNPase mRNA by RT-PCR thus appears to be a new useful parameter for identifying both a poor prognosis and a highly malignant potential of oesophageal carcinoma.  (+info)

Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue (or in cells that display epithelial characteristics) that bear microscopic resemblance to lymphoepithelioma (nasopharyngeal carcinoma). There is considerable variation in the classification of LELC-while it is perhaps most commonly considered a subtype of squamous cell carcinoma, it can also be classified as a form of large cell carcinoma (i.e. when occurring in the lung), and can be considered as a separate, unique entity. In most anatomical sites, many cases are associated with the Epstein-Barr virus. In the breast, the macroscopic, microscopic, epidemiologic, and prognostic features of LELC are very similar to medullary carcinoma; EBV status is one differentiator. Nasopharyngeal carcinoma Lymphoepithelioma Travis, William D; Brambilla, Elisabeth; Muller-Hermelink, H Konrad; et al., eds. ...
This study has shown that immunohistochemical expression of DBC1 was significantly associated with advanced clinicopathological factors of ovarian carcinoma such as higher tumor stage, latent distant metastasis, platinum-resistance, elevated serum level of CA125, and higher histologic grade. Moreover, DBC1 expression was significantly associated with shorter survival of ovarian carcinomas, especially in high-grade serous carcinomas. In agreement with our results, increased expression of DBC1 has been reported as an indicator of poor prognosis of gastric carcinoma [15], breast carcinoma [14], colorectal carcinoma [9], esophageal carcinoma [20], clear cell renal cell carcinoma [12], diffuse large B cell lymphoma [13], and soft tissue sarcomas [13]. Nevertheless, there has been no report investigating DBC1 expression in ovarian carcinomas. Therefore, this is the first report that examined DBC1 expression in human ovarian tumors and suggests that DBC1 expression might be usable as a prognostic ...
carcinoma - MedHelps carcinoma Center for Information, Symptoms, Resources, Treatments and Tools for carcinoma. Find carcinoma information, treatments for carcinoma and carcinoma symptoms.
Anaplastic carcinoma is a rare type of thyroid cancer that can cause severe breathing difficulties. The main signs of anaplastic...
Dr. Thompson responded: Possibly. Undifferentiated carcinoma means that the tumor is not showing the normal patterns seen for a transitional or urothelial (lining of the |a href=/topics/bladder track_data={
Background : Interval carcinoma is defined as a carcinoma detected between two mammographic screening rounds after a negative screening. By some authors these carcinomas are considered to be more aggressive than screen-detected carcinomas. Methods : In a group of 937 patients referred for breast cancer in the period 1975-1990,76 interval...
Beim Carcinoma in situ der Brust unterscheiden wir 2 Formen: Das ductale und das lobuläre Carcinoma in situ. Das letztere wird von den Pathologen in der Regel nicht mehr als echtes Carcinoma...
The ICD-10 Code D09.19 is the code used for Carcinoma in situ of other urinary organs .An alternative description for this code is Carcinoma in situ of other urinary ...
Definition of Carcinoma myxomatodes with photos and pictures, translations, sample usage, and additional links for more information.
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CARCINOMA EPIDERMOIDE DE AMIGDALA PDF - Una variante anaplásica del carcinoma epidermoide, denominada linfoepitelioma en amígdala palatina/lingual, tenían menos probabilidades de aparecer en.
The case histories of six patients are presented where the diagnosis of carcinoma of the esophagus and the stomach was made at the same time by barium stud
Sigma-Aldrich offers abstracts and full-text articles by [Xiaoli Yang, Cui Wang, Changzhi Xu, Zhifeng Yan, Congwen Wei, Kai Guan, Shengli Ma, Ye Cao, Liping Liu, Deyong Zou, Xiang He, Buchang Zhang, Qingjun Ma, Zirui Zheng].
INTRODUÇÃO: O carcinoma basocelular (CBC) é o tipo de câncer cutâneo mais comum no ser humano. O aparecimento de CBC na maioria das vezes se dá de forma esporádica em indivíduos que se expõem cronicamente...
Mediante el Tratamiento Inmunobiológico Issels y sin necesidad de ningún otro tratamiento convencional, se logró una remisión completa a largo plazo de la tercera recurrencia de un carcinoma cervical avanzado de células escamosas inoperable.
Carcinomas are solid tumors arising from epithelial tissue, and account for the majority of cancer deaths in the United States. In most occurrences of carcinoma, it is the metastases that kill, not the primary tumor. The ...
http://www.mobilecrunch.com/2010/01/18/everything-you-need-to-know-about-windows-mobile-7/ Похоже, они действительно решились выбросить WM6. Возможно, даже вместе со старой командой. Честь и хвала, что я могу сказать? (Да, Zune не сильно популярный плеер. Но вот для разработчика он *на…
Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to evaluate therapeutic effects of radiation by glycerol on p53-mutant anaplastic thyroid carcinoma cells (8305c cells). To examine the effectiveness of glycerol in radiation induced lethality for anaplastic thyroid carcinoma 8305c cells, we performed colony formation assay and apoptosis analysis. Apoptosis was analyzed with Hoechst 33342 staining and DNA ladder formation assay. 8305c cells became radiosensitive when glycerol was added to culture medium before X-ray irradiation. Apoptosis was induced by X-rays in the presence of glycerol. However, there was little apoptosis induced by X-ray irradiation or glycerol alone. The binding activity of whole cell extracts to bax promoter region was induced by X-rays in the presence of glycerol but not by X-rays alone. These findings suggest that glycerol is
Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Anaplastic thyroid carcinoma presented as a large neck mass with necrosis in 82% of cases. The tumors demonstrated common extrathyroidal extension (91%). Sixty-two percent of tumors demonstrated calcification. Visceral space invasion involved the esophagus (62%), trachea (57%), and larynx (29%). Carotid artery encasement was present in 42%, and 43% involved the internal jugular vein. Sixty-three percent had lateral compartment lymphadenopathy; 58% of these nodes were necrotic, and 11% were cystic. No metastatic nodes had calcification. Central compartment lymphadenopathy was seen in 56% of cases, and lateral retropharyngeal lymphadenopathy was detected in 12%. Knowledge of these imaging features aids in guiding ...
TY - JOUR. T1 - PD-1 Blockade in Anaplastic Thyroid Carcinoma. AU - Capdevila, Jaume. AU - Wirth, Lori J.. AU - Ernst, Thomas. AU - Ponce Aix, Santiago. AU - Lin, Chia Chi. AU - Ramlau, Rodryg. AU - Butler, Marcus O.. AU - Delord, Jean Pierre. AU - Gelderblom, Hans. AU - Ascierto, Paolo A.. AU - Fasolo, Angelica. AU - Führer, Dagmar. AU - Hütter-Krönke, Marie Luise. AU - Forde, Patrick M.. AU - Wrona, Anna. AU - Santoro, Armando. AU - Sadow, Peter M.. AU - Szpakowski, Sebastian. AU - Wu, Hongqian. AU - Bostel, Geraldine. AU - Faris, Jason. AU - Cameron, Scott. AU - Varga, Andreea. AU - Taylor, Matthew. PY - 2020/8/10. Y1 - 2020/8/10. N2 - PURPOSE: Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease. As part of a phase I/II study in patients with advanced/metastatic solid tumors, patients with anaplastic thyroid carcinoma were treated with spartalizumab, a humanized ...
Rapid progression contributes to treatment failure in anaplastic thyroid carcinoma (ATC) patients. In a preliminary study, we demonstrated that some hematopoietic factors may be involved in the progression of ATC. The adaptor protein LNK, which is a negative regulator of hematopoietic cytokine signalling, has been studied extensively in malignant hematopoietic cells. However, there are few studies on LNK in solid tumours. Real-time PCR, immunohistochemistry (IHC) and western blot analysis of LNK were performed on ATC cells, differentiated thyroid cancer (DTC) cells and normal thyroid cells. In vitro assays (including pull-down, liquid chromatography-mass spectrometry (LC-MS), co-IP, MTT and colony formation) were performed to validate the effect of LNK on ATC progression and elucidate the molecular mechanisms. Compared with DTC cells and normal thyroid cells, ATC cells exhibit overexpression of LNK. In addition, LNK overexpression results in increased proliferation of ATC cells. Conversely, LNK
Medical information, Anaplastic carcinoma of the thyroid. Definition of Anaplastic carcinoma of the thyroid, symptoms of Anaplastic carcinoma of the thyroid, treatment of Anaplastic carcinoma of the thyroid, and prevention of Anaplastic carcinoma of the thyroid. Exams and Tests Anaplastic carcinoma of the thyroid.
This study aims to determine the functional roles of microRNA-34b-5p (miR-34b) in the suppression of anaplastic thyroid carcinoma. We used hydration-of-freeze-dried-matrix (HFDM) formulated liposomes (liposome-loaded miR-34b) for effective delivery of miR-34b to anaplastic thyroid carcinoma in vitro and in vivo. Real time polymerase chain was used to determine the level of miR-34b. Immunocytochemistry, Western blot and ELISA were carried out to determine the effect of this manipulation on VEGF-A expression. In addition, an in vivo xenotransplantation mouse model was used to investigate the functional roles of overexpression of miR-34b in the carcinoma. In anaplastic thyroid carcinoma cells, miR-34b expression was low and significant overexpression (p , 0.05) was noted following transfection with liposome-loaded miR-34b. The miR-34b overexpressed thyroid carcinoma cell lines showed reduction in VEGF-A protein expression, decreased cell proliferation, decreased wound healing, reduced cell cycle ...
TY - JOUR. T1 - Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1. T2 - A paradigm shift that impacts current therapeutic strategies. AU - Marlow, Laura A.. AU - von Roemeling, Christina A.. AU - Cooper, Simon J.. AU - Zhang, Yilin. AU - Rohl, Stephen D.. AU - Arora, Shilpi. AU - Gonzales, Irma M.. AU - Azorsa, David O.. AU - Reddi, Honey V.. AU - Tun, Han W. AU - Dö ppler, Heike R.. AU - Storz, Peter. AU - Smallridge, Robert Christian. AU - Copland, John A III. PY - 2012. Y1 - 2012. N2 - The Forkhead transcription factor, FoxO3a, is a known suppressor of primary tumor growth through transcriptional regulation of key genes regulating cell cycle arrest and apoptosis. In many types of cancer, in response to growth factor signaling, FoxO3a is phosphorylated by Akt, resulting in its exclusion from the nucleus. Here we show that FoxO3a remains nuclear in anaplastic thyroid carcinoma (ATC). This correlates with lack of Akt phosphorylation at ...
Lymphoepitheliomas are malignant epithelial tumors of the nasopharynx characterized by an important lymphoid proliferation at histological examination. Lymphoepithelioma-like carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. We report the case of a 64-year-old Moroccan man who presented with macroscopic hematuria. Investigations revealed a muscle-invasive lymphoepithelioma-like carcinoma of the bladder. Therefore he underwent a radical cystoprostatectomy with a good outcome. This case illustrates pathogenic, clinical and therapeutic features of this unusual tumor.
Health, ...Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer wit...Led by Professor H. Phillip Koeffler Senior Principal Investigator a...Thyroid cancer is the most common cancer of the endocrine system. ATC ... The effect of LAMC2 on ATC cells ...,NUS,researchers,make,new,discovery,of,protein,as,a,promising,target,for,treatment,of,ATC,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Nasopharyngeal Carcinoma. Nasopharyngeal carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.. Nasopharyngeal carcinoma is difficult to detect early, probably because the nasopharnyx isnt easy to examine and symptoms of nasopharyngeal carcinoma mimic those of many other conditions. Your main treatment options for nasopharyngeal carcinoma are radiation therapy, chemotherapy or a combination of the two. You can work with your doctor to determine the exact approach depending on your particular situation.. Risk factors. Nasopharyngeal carcinoma is common in Southern China. It often affects people aged 30 and older, but occasionally can be seen in the young, including children. It is twice as common in women.. Several risk factors have been found with nasopharyngeal cancer:. Diet: In areas where nasopharyngeal carcinomas are common, people typically eat diets very high in salted fish and preserved meat from a young ...
Purpose: The study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.. Methods: Over a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.. Results: The prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more ...
Mucinous tubular and spindle cell carcinoma of the kidney (MTSCC-K) is an unusual renal tumor. cords or tubules, in a tightly packed arrangement. Myxoid stroma was shown to be interspersed among the tubular cells, and appeared to exhibit slender tubular spindle cell-like structures. Tumor cells were smaller and cube-shaped or oval, with single small eosinophilic nucleoli and low-grade nuclei. Occasionally, necrosis and foam cell infiltration were observed. Myxoid stroma was stained by acidic mucus. Immunohistochemical markers, including CK7, CK19, EMA, Vimentin and P504S (AMACR) showed positive expression in tumoral cells, but the tumoral cells were CD10-negative. The MTSCC-K is a low-grade polymorphic renal epithelial neoplasm, which may be diagnosed by immunohistochemistry. The patients are likely to have an improved prognosis following surgery compared with patients with other renal cell carcinomas. and was known as a low-grade collecting duct carcinoma (2). As the number of MTSCC-K cases ...
Nasopharyngeal carcinoma (NPC) is a cancer originating in the nasopharynx (the uppermost region of the pharynx), where the nasal passages and auditory tubes join the remainder of the upper respiratory tract. On microscopic histopathological analysis, abundant dense eosinophilic cytoplasm and prominent lymphoid component are characteristic findings of nasopharyngeal carcinoma. Nasopharyngeal carcinoma differs significantly from other cancers of the head and neck in occurrence, causes, clinical behavior, and treatment. Common risk factors in the development of nasopharyngeal carcinoma are Chinese (or Asian) ancestry, Epstein-Barr virus (EBV) exposure, and heavy alcohol intake. Nasopharyngeal carcinoma must be differentiated from normal adenoidal tissue, nasopharyngeal lymphoma and chordoma. It is vastly more common in certain regions of East Asia and Africa than elsewhere, with viral, dietary, and genetic factors implicated in its causation. The prevalence of nasopharyngeal carcinoma is ...
If the tumor has all of these features, it is considered to be a true medullary carcinoma. Sometimes the tumor has only some of these features but not others, or there may be some invasive ductal carcinoma cells mixed in. In these cases, your doctor may call the tumor atypical medullary carcinoma.. In addition, medullary carcinoma cells often express a protein called p53. The pathologist may test for p53 to help decide if the cancer is truly medullary.. There are some other key features of medullary carcinoma:. ...
Staging of carcinoma refers to the process of combining physical/clinical examination, pathological review of cells and tissues, surgical techniques, laboratory tests, and imaging studies in a logical fashion to obtain information about the size of the neoplasm and the extent of its invasion and metastasis. Carcinomas are usually staged with Roman numerals. In most classifications, Stage I and Stage II carcinomas are confirmed when the tumor has been found to be small and/or to have spread to local structures only. Stage III carcinomas typically have been found to have spread to regional lymph nodes, tissues, and/or organ structures, while Stage IV tumors have already metastasized through the blood to distant sites, tissues, or organs. In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable only via examination of sputum for malignant cells (in lung carcinomas). In more recent staging systems, substages (a, b, c) are becoming ...
Radiation and chemotherapy are common treatments for anaplastic carcinoma. Learn about treatments for anaplastic carcinoma, a type of thyroid cancer.
Hemonc Today | The American Thyroid Association has released the first set of comprehensive guidelines for the management of anaplastic thyroid cancer, a rare but lethal form of thyroid cancer. Members of the American Thyroid Association (ATA) task force compiled a list of 65 recommendations based on relevant literature.
It was reported previously that the specific aim of screening agents that would induce apoptosis in the human breast carcinoma cell line MDA-MB-231 was completed, and that calyculin A was the most effective compound tested. Since then Cdc25 phosphatases were reported as possible key oncogenes in human breast carcinoma. In light of our results with calyculin A, it was decided that a more promising focus for the project would be the biochemical basis for the oncogenic actions of Cdc25 phosphatases in human breast carcinoma. At this time we have examined 18 compounds and discovered a Cdc25 phosphatase inhibitor, called 1f, that selectively inhibits Cdc25A,B, and C, has antiproliferative activity against and causes a G1 block in MDA-MB-231 cells. The pure form of this compound and two other compounds which selectively inhibit Cdc25 phosphatases have been made and also demonstrate an equal if not better inhibition of Cdc25 phosphatases as their combinatorial form.*HUMANS
Information about anaplastic thyroid cancer, a rare but deadly form of thyroid cancer that mainly affects men over the age of 65.
The Anaplastic Thyroid Cancer GUIDELINES Pocket Card is endorsed by the American Thyroid Association reflects the latest ATA recommendations. This practical quick-reference tool contains graded recommendations for diagnosis, including immunohistochemical markers, and treatment of local, regional and metastatic disease with management algorithms and tables of chemotherapy and adjuvant/radiosensitizing regimens. Also included are recommendations for palliative care and long-term monitoring. Spiral Bound 14 pages 80# Diamond Silk Cover with Satin Aqueous Coating 4.5″ x 7.25″
This form of cancer has an extremely low cure rate. The best treatments available allow only 10% of patients live 3 years after diagnosis. A larger percentage of patients diagnosed with it do not live beyond one year from the day cancer is diagnosed. It can arise within a different type of thyroid cancer. It can even form within a goiter. Anaplastic thyroid cancer can develop after many, many years following radiation exposure. Papillary cancer develops the same way. Cervical metastasis is when the cancer spreads to the lymph nodes in the neck. This is present in over 90% of patients diagnosed with anaplastic thyroid cancer. The appearance of lymph node metastasis in cervical areas cause much higher recurrence rate of anaplastic thyroid cancer and increases a patients mortality rate. The cancer becomes noticeable as growing neck mass. It can feel large and very hard. This type of tumor grows very quickly. It may grow so quickly that the patient may not even notice it at first. All of a sudden, ...
It was confirmed that CD147 (Emmprin) was expressed on the cell surface of carcinoma cells. For the purpose of studying the efficacy of a CD147-targeting agent on CD147-expressing carcinoma cells, we investigated the effect of a conjugate of glutathione-doxorubicin (GSH-DXR) encapsulated in an anti-CD147 antibody-labeled liposome (aCD147ab-liposome) in terms of specific accumulation and cytotoxicity in CD147-expressing human carcinoma cells. Expression of CD147 was not observed in many normal human tissues. However, slight expression of CD147 in kidney, prostate and breast tissues was observed. By contrast, high-level expression of CD147 in all carcinoma cells such as A431, PC3 and Ishikawa cell lines was confirmed by fluorescent microscopy and Western blot analysis. Specific accumulation of the aCD147ab-liposome in the above-described CD147-expressing cells was observed. GSH-DXR encapsulated in an aCD147ab-liposome expressed specific cytotoxicity against these carcinoma cells. These results ...
TY - JOUR. T1 - Pathology of stage I versus stage III ovarian carcinoma with implications for pathogenesis and screening. AU - Yemelyanova, A. V.. AU - Cosin, J. A.. AU - Bidus, M. A.. AU - Boice, C. R.. AU - Seidman, J. D.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - The progression of ovarian carcinoma from stage I when it is confined to the ovaries and curable to disseminated abdominal disease, which is usually fatal, is poorly understood. An accurate understanding of this process is fundamental to designing, testing, and implementing an effective screening program for ovarian cancer. Pathologic features of the primary ovarian tumors in 41 FIGO stage I ovarian carcinomas were compared with those in 40 stage III carcinomas. The primary ovarian tumors in stage I cases, when compared with stage III, respectively, were significantly larger (15.4 versus 9.8 cm), were less frequently bilateral (12% versus 75%), more frequently contained a noninvasive component (88% versus 30%), had a higher proportion of a ...
TY - JOUR. T1 - How matching may impact interpretation. T2 - Comments on A matched-cohort analysis of 192 pancreatic anaplastic carcinomas and 960 pancreatic adenocarcinomas: A 13-year North American experience using the National Cancer Data Base (NCDB). AU - Bergquist, John R.. AU - Thiels, Cornelius A.. AU - Storlie, Curtis B.. AU - Nagorney, David M.. AU - Truty, Mark J.. PY - 2016/12/1. Y1 - 2016/12/1. UR - http://www.scopus.com/inward/record.url?scp=84979650457&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84979650457&partnerID=8YFLogxK. U2 - 10.1016/j.surg.2016.05.011. DO - 10.1016/j.surg.2016.05.011. M3 - Letter. C2 - 27365227. AN - SCOPUS:84979650457. VL - 160. SP - 1714. EP - 1715. JO - Surgery (United States). JF - Surgery (United States). SN - 0039-6060. IS - 6. ER - ...
TY - JOUR. T1 - Nasopharyngeal carcinoma in children-A retrospective review and demonstration of epstein-barr viral genomes in tumor cell cytoplasm. T2 - A report of the pediatric oncology group. AU - Hawkins, Edith P.. AU - Krischer, Jeffrey P.. AU - Smith, Billie E.. AU - Hawkins, Hal K.. AU - Finegold, Milton J.. N1 - Funding Information: Support4 in part by grants from the National Cancer lnsti-tute. and National Inrtitures of Health (CA-03161, Cl-89139. CA-:~~K%i9).. PY - 1990/8. Y1 - 1990/8. N2 - Twenty-seven nasopharyngeal carcinomas were entered in the Pediatric Oncology Group Rare Tumor Registry from 1973 to 1988 (15 males, 12 females; 10 white, 15 black, two unknown; ages 8 to 17 years). Eight tumors were non-keratinizing carcinomas (World Health Organization 2) and 19 were undifferentiated (World Health Organization 3). The overall 3-year survival rate was 70% (SE 11%). Nine children developed distant metastases and two were salvaged. We found that localized tumor (P = .02) and black ...
Principal Investigator:TANIGUCHI Shin-ichi, Project Period (FY):2003 - 2004, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Endocrinology
An open right-sided neck biopsy was performed. Histology: MACROSCOPIC DESCRIPTION: Two specimens received. Right neck mass 1: Multiple irregular cream necrotic pieces of tissue measuring 20x15x4 mm in aggregate. Right neck mass 2: Multiple ta...
Hiraki, M.; Kitahara, K.; Miyoshi, A.; Koga, H.; Nakamura, H.; Kubo, H.; Ikeda, O.; Yoshioka, W.; Nakashita, S.; Nishihara, Y.; Akashi, M.; Azama, S.; Kawaguchi, Y.; Mori, D.; Aishima, S.; Aibe, H.; Tanaka, T.; Sato, S., 2018: A long-term survivor of undifferentiated carcinoma of the liver successfully treated with surgical treatments: A case report and literature review
A method of killing carcinoma cells associated normal cells using light of a predetermined wavelength. The method includes contacting the cells with a chromophor at a given concentration. The chromophor is positively charged and sufficiently lipophilic to be taken up by the mitochondria of the carcinoma cells and is retained substantially longer in the mitochondria of carcinoma cells than in normal cell mitochondria; or it may be taken up in greater quantity by the carcinoma cells than by the normal cells. The chromophor must also have a therapeutic index for light-induced cell killing of at least 500 for light of the predetermined wavelength, and has a therapeutic ratio for light-induced killing of at least 50 for light of said pre-determined wavelength. The cells are then exposed to light of this wavelength.
The most striking finding of this study was that the dimension of symptom intensity and the dimension of symptom distress were not equivalent. There also was remarkable consistency in the TSSD-LC data on symptom distress over time in all subgroups examined, whereas patterns of intensity were highly variable. The 3 symptoms-breathing, pain, and fatigue-were associated with the most distress in this sample of 400 patients with inoperable lung carcinoma.. It should be noted, however, that the sample in this study represents the healthiest of this very ill patient group, because participants were younger and had longer survivals than both nonparticipants and the population of patients with inoperable lung carcinoma registered in the same geographic area. Recruitment and participation in this study compared favorably with other studies, considering the well acknowledged difficulties in researching patients with lung carcinoma, debilitated patients, and women with lung carcinoma.3, 27-30 The low ...
Interleukin-18 (IL-18) is a single-chain cytokine that is produced by various cells. With interleukin-12 (IL-12), it synergistically stimulates activated T cells and natural killer (NK) cells to produce interferon-γ (IFN-γ). Nasopharyngeal carcinoma (NPC) is the most common form of nasal and nasopharyngeal malignancy, and in NPC tumor tissues there is an intense leukocyte infiltration comprising predominantly T cells and macrophages. We previously showed an increased expression of IFN-γ in the infiltrating T cells. To identify the cells that provide IL-12 and IL-18 for stimulating the expression of IFN-γ in activated T cells, NPC cell lines CNE-2 and HK-1, as well as biopsies obtained from NPC and control individuals, were examined. CNE-2 and HK-1 cells were found to express messenger RNA encoding IL-18, but not IL-12. Secreted IL-18 was detected in the culture supernatant. Addition of a caspase-1 inhibitor decreased the secretion level, indicating that this IL-18 secretion was caspase-1 ...
Another name for Gastric Carcinoma is Gastric Carcinoma. It is important to follow a healthy diet if you have gastric carcinoma. Cancer and Chemotherapy ...
Diffuse-type gastric carcinoma (DGC) cell lines with robust overexpression of Met are sensitive to Met inhibitors. (a) DGC and other gastric carcinoma cell line
This is a case report of a 33-year-old woman who presented 5 days post-partum with abdominal distension, abdominal discomfort, increased bladder pressure and fatigue. These symptoms prompted a pelvic ultrasound and CT scan of the chest, abdomen and pelvis which showed a large 20 cm left-sided adnexal mass. Following this imaging, blood tests revealed elevated tumour markers CA-125 and lactate dehydrogenase, resulting in referral to and surgical intervention by the gynaecology oncology team. Pathology and immunohistochemistry indicated that the tumour was a metastasis from the colon, that prompted for colonoscopy which confirmed that the carcinoma was a metastases from the sigmoid.. ...
class III nasopharyngeal carcinoma in the WHO classification system (Lymphoepithelioma) -- For more information on this topic, see Nasopharyngeal carcinoma Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor. fact lexicon with terms going straight to the point. Facts are sorted by community importance and you can build your personalized lexicon
Nasopharyngeal carcinoma in New Delhi Gurgaon Noida Faridabad NCR or Online Treatment of Nasopharyngeal carcinoma Contact Us or Fill Up Form Contact Us
Help. I have just put out a message on ask for advice. But I need to get all the informaton I can on this type of cancer. FRiday my mother in law was here with...
Cancer of unknown primary site represents approximately 3% to 5% of all new cancer diagnoses. Adenocarcinomas account for 60% of all unknown primary cancers and poorly differentiated carcinomas or 1
Prognostic relevance of LGALS3BP in human colorectal carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Ovarian cancer is a cancer that forms in an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. SK-OV-3, NIH:OVCAR-3 and HO-8910 are the ovarian carcinoma cell lines derived from human ovarian tumor. Studies were carried out to determin
Introduction. While most types of thyroid cancer are treatable, anaplastic thyroid cancer (ATC) is the most lethal human malignancy. Current treatment strategies are largely ineffective with only 10% of patients surviving longer than one year. As such, new treatments are desperately needed to improve patient survival in this aggressive cancer.. Objective. Identify highly effective drugs using high-throughput screening methods with a large panel of kinase inhibitors that can be used in the treatment of ATC.. Methods. High-throughput screening (HTS) of 13 genetically characterized ATC cell lines was carried out over a 6-dose range using 320 kinase inhibitors. Dose-response curves were generated and drugs with high potency were identified. Drugs with the highest activity were selected for further evaluation including investigating mechanism of action and cell death, and assays for migration and invasion.. Results. Based on HTS studies, Lestaurtinib was identified as a highly effective agent with ...
Sarcoma and Carcinoma are both types of cancers or malignant tumors. Sarcomas grow in the connective tissues and bones, whereas Carcinoma starts on the surface or lining of a body organ. They both grow and spread in different manner.
Prostaglandin E2 (PGE2) secretion by peripheral blood and tissue-fixed macrophages from patients with colorectal carcinoma was assessed. There was no significant difference between PGE2 production by peripheral blood mononuclear cells between patients with colorectal carcinoma and normal controls. H …
Historically, endometrial carcinomas have been classified primarily according to their histology. However, the use of immunohistochemistry has become commonplace in their evaluation, particularly in diagnostically challenging cases. Our objective was to evaluate mixed endometrial carcinomas using a
Dada la resistencia a la quimioterapia que presenta el melanoma y el carcinoma de endometrio avanzado, es importante aquella investigación destinada a buscar dianas terapéuticas. En este trabajo hemos investigado los efectos de análogos de la somatostatina (SAs), de inhibidores del proteasoma (PI) como Bortezomib, del inhibidor de receptores tirosina cinasa Sunitinib y la combinación de Sunitinib y Bortezomib en líneas celulares de melanoma. Esta combinación también la hemos testado en el carcinoma de endometrio. Se observa que las células de melanoma expresan varios receptores de la somatostatina. Los PI son eficientes a la hora de inducir una parada en el ciclo celular y apoptosis. Las líneas celulares que presentan PDGFR α i VEGFR2 son sensibles a Sunitinib, y éste interacciona con Bortezomib de forma sinérgica. En el carcinoma de endometrio, Sunitinib induce una parada en el ciclo celular, apoptosis, inhibe la via NFκB e interacciona sinérgicamente con Bortezomib. Los SAs y PI ...
Lobular carcinoma in situ (inside) is a high-risk condition. It originates in the milk-producing lobes and is rarely thought to develop into breast cancer. A history of this carcinoma may put you at a higher risk of developing breast cancer.
We have shown recently that the hyaluronan receptor, CD44, and matrix metalloproteinase 9 (MMP-9) form a complex on the surface of TA/St mouse mammary carcinoma cells that activates latent transforming growth factor-beta (TGF-beta) and is required for tumor invasion. Disruption of the CD44/MMP-9 com …
Sn(n-Bu)OSPRR(5), (R = O-phenyl; R= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.. ...
histiocytoid breast carcinomaは,本邦の報告では全乳癌の0.3%とされている非常にまれな組織型であり,確立された診断基準や腫瘍概念が存在しない。その発生母地となる病態としては浸潤性小葉癌の亜型とされていたが,乳管由来と思われる成分やアポクリンへの分化を認める報告もあり,本腫瘍の発生母地となっている病態は多岐にわたる。本邦の報告例では比較的長期生存し遠隔転移を認めない症例がみられたが,今回われわれは,多発腋窩リンパ節転移を伴ったhistiocytoidbreast carcinomaの1 例を経験した。今後症例を蓄積し,その分類や臨床的特徴などを確立することが必要であると考える。
Oral carcinoma[edit]. Patients after HSCT are at a higher risk for oral carcinoma. Post-HSCT oral cancer may have more ...
Thyroglossal duct cyst carcinoma[edit]. Rarely, cancer may be present in a thyroglossal duct cyst. These tumors usually arise ... Ali M.; Abussa A.; Hashmi H. (2007). "Papillary thyrpid carcinoma formation in a thyroglossal cyst. A case report". Libyan ... Thyroglossal duct carcinoma occurs in approximately 1 to 2% of Thyroglossal cyst cases.[20] ... McNicoll MP, Hawkins DB, England K, Penny R, Maceri DR (1988). "Papillary carcinoma arising in a thyroglossal duct cyst". ...
Basal and squamous cell carcinomas[edit]. The most common forms of skin cancer in humans, basal and squamous cell carcinomas, ... These cancers are relatively mild and rarely fatal, although the treatment of squamous cell carcinoma sometimes requires ...
... uterine serous carcinoma, Fallopian tube serous carcinoma, cervical serous carcinoma, and primary peritoneal serous carcinoma ... Primary peritoneal cancer or carcinoma is also known as serous surface papillary carcinoma, primary peritoneal carcinoma, extra ... serous carcinoma, primary serous papillary carcinoma, psammomacarcinoma. It was historically classified under "carcinoma of ... Primary peritoneal carcinoma shows similar rates of tumor suppressor gene dysfunction (p53, BRCA, WT1) as ovarian cancer and ...
Advanced non-smallcellular lung carcinoma[edit]. Mutations in the kinase domain of the EGFR are observed with approximately 2 ... several phase II studies investigating the treatment of advanced stomach carcinoma were conducted. At the conference of the ... to 25% of non-small cell lung carcinoma (NSCLC) patients. Some studies have shown a negative correlation between the ...
... s are usually named using -carcinoma, -sarcoma or -blastoma as a suffix, with the Latin or Greek word for the organ or ... For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... Carcinoma: Cancers derived from epithelial cells. This group includes many of the most common cancers and include nearly all ... Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle ...
Solivan, GA; Smith, KJ; James, WD (1990). "squamous cell carcinoma". Journal of the American Academy of Dermatology. 23 (5 Pt 2 ... The incidence of squamous cell carcinoma increases to 37% when the cutaneous horn is present on the penis.[3] Tenderness at the ... Malignancy is present in up to 20% of cases, with squamous cell carcinoma being the most common type. ... or squamous cell carcinoma (a form of skin cancer). These can look essentially identical clinically. The only reliable way to ...
Carcinoma, the majority of cancer cells are epithelial in origin, beginning in the membranous tissues that line the surfaces of ...
"Squamous cell carcinoma (epidermoid carcinoma) - skin". Atlas of Pathology (3rd ed.). Universitatii St., Iasi, Romania. ... The most common form of skin cancer is basal-cell carcinoma, followed by squamous cell carcinoma. Unlike for other cancers, ... whereas it might be inadequate for invasive nodular basal-cell carcinoma or invasive squamous-cell carcinoma.[citation needed] ... sebaceous carcinomas, microcystic adnexal carcinoma, Paget's disease of the breast, atypical fibroxanthoma, leiomyosarcoma, and ...
... spindle cell carcinoma, and small-cell carcinoma.[citation needed] ... Cancers are usually named using -carcinoma, -sarcoma or -blastoma as a suffix, with the Latin or Greek word for the organ or ... For example, the most common type of breast cancer is called ductal carcinoma of the breast. Here, the adjective ductal refers ... Carcinoma: Cancers derived from epithelial cells. This group includes many of the most common cancers, particularly in older ...
Moy, RL (Jan 2000). "Clinical presentation of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Salasche, SJ (January 2000). "Epidemiology of actinic keratoses and squamous cell carcinoma". Journal of the American Academy ... Kivisaari, Atte (2013). "Squamous cell carcinoma of the skin: Emerging need for novel biomarkers". World Journal of Clinical ...
Callus, seborrheic keratosis, squamous cell carcinoma[4]. Treatment. Salicylic acid, cryotherapy[1]. ...
Ovarian Carcinoma: Cancer that forms in tissues of the ovary. Most ovarian cancers are either ovarian epithelial carcinomas ( ... Mucinous appendiceal carcinoma: A type of cancer that begins in cells that line the appendix and produce mucin (the main ... Thymoma and Thymic carcinoma: These tumors which arise from the thymus gland in the upper part of the chest overlying the heart ... uterine and renal cell carcinoma among others ; as well as certain sarcomas and pseudomyxoma peritonei. ...
Ductal carcinoma in situ (DCIS): Paget's disease of the breast. *Comedocarcinoma. *Invasive ductal carcinoma (IDC) ...
Tissue biopsy is not usually required, unless to rule out other suspected conditions such as oral squamous cell carcinoma.[18] ...
Non-small-cell lung carcinoma[edit]. Micrograph of squamous-cell carcinoma, a type of non-small-cell carcinoma, FNA specimen, ... are carcinomas.[12] The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC).[3] The ... For therapeutic purposes, two broad classes are distinguished: non-small-cell lung carcinoma and small-cell lung carcinoma.[66] ... bronchial gland carcinomas and sarcomatoid carcinomas.[6]. Metastasis[edit]. Typical Napsin-A and TTF-1 immunostaining in ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Sebaceous carcinoma, an uncommon and aggressive cutaneous tumour.[37]. *Sebaceous cyst is a term used to refer to both an ... Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM (July 1995). "Sebaceous carcinoma". J. Am. Acad. Dermatol. 33 (1): 1-15, ...
... renal cell carcinoma of chromophobe, hybrid oncocytic, or oncocytoma histology; sebaceous carcinoma; and sex cord tumors with ... but also increases the risk of fallopian tube carcinoma and papillary serous carcinoma of the peritoneum. In men the risk of ... Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is an autosomal dominant cancer syndrome in which ... Manfredi M, Vescovi P, Bonanini M, Porter S (March 2004). "Nevoid basal cell carcinoma syndrome: a review of the literature". ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
The most common type of oral cancer is squamous cell carcinoma. The main causes are long-term smoking and alcohol consumption ( ... Malignancies in the mouth are usually carcinomas, but lymphomas, sarcomas and others may also be possible. Either the tumor ...
Merkel-cell carcinoma. RNA virus. HCV Hepatocellular carcinoma. Splenic marginal zone lymphoma. HTLV-I Adult T-cell leukemia/ ... Hepatocellular carcinoma. HPV Cervical cancer. Anal cancer. Penile cancer. Vulvar cancer. Vaginal cancer. Oropharyngeal cancer ... El-Serag HB (22 September 2011). "Hepatocellular carcinoma". New England Journal of Medicine. 365 (12): 1118-27. doi:10.1056/ ... This type of infection dramatically increases the incidence of hepatocellular carcinoma (HCC; liver cancer). Across Europe, ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). ... and these cancers are classified as ductal or lobular carcinoma. Carcinoma in situ is growth of low-grade cancerous or ... Breast changes like atypical ductal hyperplasia[63] and lobular carcinoma in situ,[64][65][66] found in benign breast ... "Lobular carcinoma in situ: Marker for breast cancer risk". MayoClinic.com. Archived from the original on 2 January 2014.. ...
Micrograph of a small-cell carcinoma showing cells with nuclear moulding, minimal amount of cytoplasm and stippled chromatin. ... these include leukemia and most forms of carcinoma in situ. Tumor is also not synonymous with cancer. While cancer is by ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Malignant: Adenosquamous carcinoma. *Basaloid squamous carcinoma. *Mucosal melanoma. *Spindle cell carcinoma. *Squamous cell ...
Anaplastic carcinoma is a rare type of thyroid cancer that can cause severe breathing difficulties. The main signs of ... Is anaplastic carcinoma seen often in people with hypothyroidism? I have hypothyroidism and if I had anaplastic carcinoma, I ... Anaplastic carcinoma is a rare but very deadly form of thyroid cancer that can cause severe breathing difficulties. Symptoms ... turkay1-- My grandmother died from anaplastic thyroid carcinoma and I know from her case that this type of cancer also causes ...
... se logró una remisión completa a largo plazo de la tercera recurrencia de un carcinoma cervical avanzado de células escamosas ... Diagnóstico: Carcinoma cervical inoperable etapa III.. Histología: Carcinoma de células escamosas queratinizado. Instituto ... se logró una remisión completa a largo plazo de la tercera recurrencia de un carcinoma cervical avanzado de células escamosas ...
Definition of Carcinoma myxomatodes with photos and pictures, translations, sample usage, and additional links for more ... carcinoma in situ. carcinoma myxomatodes (current term). carcinoma simplex. carcinomal. carcinomas. carcinomata. carcinomatoses ... Medical Definition of Carcinoma myxomatodes. 1. An obsolete term for a form of colloid cancer in which there is myxomatous ... Carcinoma Myxomatodes Pictures. Click the following link to bring up a new window with an automated collection of images ...
Una variante anaplásica del carcinoma epidermoide, denominada linfoepitelioma en amígdala palatina/lingual, tenían menos ... Carcinoma epidermoide de cabeza y cuello . Se ha llevado a cabo un estudio retrospectivode 34 pacientes con carcinoma ... Carcinoma of the amjgdala fossa: The information has been completed with other bibliographic sources such as cancer registries ... En consecuencia, la mayor parte de los carcinomas de la lengua ocurren en los bordes de los dos tercios anteriores y la ...
ask our ebook Carcinoma of the Kidney 2007 flow Dreaming; promote the latest men and more. ... unavailable for good ebook Carcinoma of the writer-in-residence, leveling, mistype and detailed community scientist. corner ... 13 ebook Carcinoma of the more than the lack! not discuss the ebook Carcinoma of clear writing. And ebook Carcinoma of the ... Our ebook Carcinoma of the Kidney unit and none resources and sites can ADD accessed now. I are to the ebook Carcinoma of the ...
In some types of carcinomas, Stage 0 carcinoma has been used to describe carcinoma in situ, and occult carcinomas detectable ... Some carcinomas are named for their or the putative cell of origin, (e.g.hepatocellular carcinoma, renal cell carcinoma). ... Carcinoma In situ[edit]. The term carcinoma in situ (or CIS) is a term for cells that are significantly abnormal but not cancer ... and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). Pleomorphic carcinoma contains spindle cell and/or ...
Targeting renal cell carcinoma with a HIF-2 antagonist.. Chen W1,2,3, Hill H1,2, Christie A1, Kim MS1,4, Holloman E1,2, Pavia- ... Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL ... The therapeutic potential of HIF-2 antagonism in renal cell carcinoma. [Transl Androl Urol. 2017] ... Re: Targeting Renal Cell Carcinoma with a HIF-2 Antagonist. [Eur Urol. 2017] ...
Diseases : Breast Cancer: Ductal Carcinoma In Situ, Ductal Carcinoma: Invasive. Anti Therapeutic Actions : Biopsy: Various ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: MMTV-Associated, Ductal Carcinoma: Invasive ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: MMTV-Associated, Ductal Carcinoma: Invasive ... Diseases : Breast Cancer, Breast Cancer: Ductal Carcinoma In Situ, Breast Cancer: Lobular Carcinoma in Situ (LCIS) ...
... treatment and resreatch studies about kidney and renal cell carcinoma for the medical professionals while caring for their ... The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate ... Study reveals a 38% decreased risk of death in patients with papillary metastatic renal cell carcinoma who undergo ... associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma. ...
Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). Here we have ... Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue. ... Squamous cell carcinoma of the oral tongue, endocannabinoids, cyclooxygenase-2, N-acyl- osphatidylethanolamine phospholipase D ...
Sebaceous carcinoma is an uncommon and aggressive malignant cutaneous tumor.[1] Most are typically about 10 mm in size at ... Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 ... Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them.[1][2] ... This type of carcinoma is commonly managed by local resection, cryotherapy, topical chemotherapy, and radiotherapy. Multimodal ...
... characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma ( ... In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide ... Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic ... Measurement of Protein Expression of p53, p21WAF1, and Rb in Patients with Surgically Treated Hepatocellular Carcinoma by Using ...
... follicular variant of papillary carcinoma and poorly differentiated carcinoma-as well as the problems raised by the newly ... It will address the differential diagnosis between follicular carcinoma and three tumor types-follicular adenoma, ... well-differentiated tumor of uncertain malignant potential and well-differentiated carcinoma, not otherwise specified. Finally ... Follicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well- ...
there are two types: * ductal carcinoma in situ, also called intraductal carcinoma * in ... From: Invasive Ductal Carcinoma (IDC) & Ductal Carcinoma In Situ (DCIS) WebMD Medical Reference ... Breastcancer.org: "DCIS - Ductal Carcinoma In Situ," "Invasive ductal carcinoma," "Treatment for DCIS." ... Breastcancer.org: "DCIS - Ductal Carcinoma In Situ," "Invasive ductal carcinoma," "Treatment for DCIS." ...
This year the number of papers published regarding hepatocellular carcinoma (HCC) continued to increase compared with last year ...
Gain a better understanding of cystic renal cell carcinoma and the best approaches to diagnosing and managing this uncommon ... Table 2. The character of cystic renal cell carcinoma concurrent renal cell carcinomas Pt. No.. Age (yr). Sex. Mass location ( ... Cystic renal cell carcinoma (CRCC) is relatively rare; it represents a special subtype of renal cell carcinoma (RCC) associated ... Cystic Renal Cell Carcinoma. A Report of 67 Cases Including 4 Cases With Concurrent Renal Cell Carcinoma. ...
... is a rare cause of primary hyperparathyroidism, which is usually caused by a parathyroid adenoma and ... Parathyroid carcinoma: a review. Head Neck 2011; 33:429.. *Busaidy NL, Jimenez C, Habra MA, et al. Parathyroid carcinoma: a 22- ... Parathyroid carcinoma. Authors. Ghada El-Hajj Fuleihan, MD, MPH. Ghada El-Hajj Fuleihan, MD, MPH ... Non-functional parathyroid carcinoma: a review of the literature and report of a case requiring extensive surgery. Head Neck ...
... Liver cancer, primarily hepatocellular carcinoma (HCC), is the third ... Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths in the United States and worldwide; infection with hepatitis ... Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27 ... Alternate Text: The figure above shows the hepatocellular carcinoma average annual incidence rate, by sex in the United States ...
Carcinoma of Breast. Br Med J 1958; 1 doi: https://doi.org/10.1136/bmj.1.5067.395 (Published 15 February 1958) Cite this as: Br ...
Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are two triangle-shaped glands. One gland ... Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are two triangle-shaped glands. One gland ... Allolio B, Fassnacht M. Adrenocortical carcinoma. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult ... Adrenocortical carcinoma treatment (Adult) (PDQ) - health professional version. www.cancer.gov/types/adrenocortical/hp/ ...
The most common form of liver cancer in adults is hepatocellular carcinoma. Learn about diagnosis, treatment and taking part in ... ClinicalTrials.gov: Carcinoma, Hepatocellular (National Institutes of Health) * ClinicalTrials.gov: Hepatoblastoma (National ... Article: S100 family members: potential therapeutic target in patients with hepatocellular carcinoma:... ... Article: AGLR is a novel index for the prognosis of hepatocellular carcinoma... ...
Multiple Primary Carcinoma. Br Med J 1950; 2 doi: https://doi.org/10.1136/bmj.2.4670.107-c (Published 08 July 1950) Cite this ...
Source for information on oat-cell carcinoma: A Dictionary of Nursing dictionary. ... oat-cell carcinoma (oht-sel) n. see small-cell lung cancer. ... oat-cell carcinoma (oht-sel) n. see small-cell lung cancer. ... oat-cell carcinoma A Dictionary of Nursing © A Dictionary of Nursing 2008, originally published by Oxford University Press 2008 ... www.encyclopedia.com/caregiving/dictionaries-thesauruses-pictures-and-press-releases/oat-cell-carcinoma ...
... Most skin cancers, including Merkel cell carcinoma (MCC), are brought to a doctors attention ... Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. J Am Acad Dermatol. 2018;78(3):433-442. ... For more on this test and what the results could mean, see Surgery for Merkel Cell Carcinoma. ... National Comprehensive Cancer Network, Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Merkel Cell Carcinoma, ...
Merkel Cell Carcinoma Risk Factors. A risk factor is anything that raises your chance of getting a disease such as cancer. ... Merkel cell carcinoma: An update and review: Pathogenesis, diagnosis, and staging. J Am Acad Dermatol. 2018;78(3):433-442. ... Having a risk factor for Merkel cell carcinoma (MCC), or even many risk factors, doesnt mean that you will get it. Most people ... Tetzlaff MT, Nagarajan P. Update on Merkel Cell Carcinoma. Head Neck Pathol. 2018;12(1):31-43. ...
... are called lobular carcinomas and ductal carcinomas. Because these tissues are glandular, both cancers are called ... The most common type of tumour, called infiltrating ductal carcinoma, is a single, hard, barely movable lump. This type of ... are called lobular carcinomas and ductal carcinomas. Because these tissues are glandular, both cancers are called ... The most common type of tumour, called infiltrating ductal carcinoma, is a single, hard, barely movable lump. This type of ...
Penile Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and ... Squamous cell carcinoma HPV Penile intraepithelial neoplasia TNM8 Lichen sclerosus This is a preview of subscription content, ... Clinicopathological features of carcinoma of the distal penile urethra. Semin Diagn Pathol. 2015a;32:238-44.CrossRefGoogle ... The role of pathologic prognostic factors in squamous cell carcinoma of the penis. World J Urol. 2009;27:169-77.CrossRefGoogle ...
Renal cell carcinoma is responsible for about 90 percent of kidney cancers in adults. Renal cell carcinoma appears to be caused ... Renal cell carcinoma, a disease arising from malignant epithelial cells in the kidneys. ... Renal cell carcinoma, a disease arising from malignant epithelial cells in the kidneys. Renal cell carcinoma is responsible for ... carcinoma. Carcinoma. , a cancerous growth of surface (epithelial) tissues of the skin, digestive tract, blood vessels, and ...
English: Lymphoepithelioma-like carcinoma (LELC) is a variant of urothelial carcinoma.. .mw-parser-output #wdinfobox{width: ... carcinoma de la vejiga, cancer de vejiga, cancer de la vejiga (es); 膀胱がん, 膀胱ガン, 膀胱腫瘍 (ja); Câncer na bexiga (pt-br); Cancro ... carcinoma della vescica (it); 膀胱癌 (zh-hans); cancer de la vessie (fr); ಮೂತ್ರಕೋಶದ ಕ್ಯಾನ್ಸರ್ (tcy); Rak mokraćnog mjehura (hr); ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Bladder_urothelial_carcinoma&oldid=330576295" ...
... and prognostic impact of metastasis in hepatocellular carcinoma, proposing a modified BCLC system based on metastasis. ... Hepatocellular carcinoma patients with metastasis at the time of diagnosis have shorter overall survival compared to patients ... Association between hepatocellular carcinoma (HCC)-related variables and metastasis stratified by total tumour volume (TTV). ... Association between hepatocellular carcinoma (HCC)-related variables and metastasis stratified by total tumour volume (TTV). ...
Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. Presented at Liver Disease awareness week 2014 ... External Beam Radiotherapy for Hepatocellular carcinoma * 1. Latest advances in radiotherapy for hepatocellular carcinoma Liver ... Latest advances in external beam radiotherapy for hepatocellulalar carcinoma. Presented at Liver Disease awareness week 2014 ...
What are the signs of papillary urothelial carcinoma, what are the causes, and what are the risk factors? ... Carcinoma in situ: What is it and how is it treated? In this article, learn about carcinoma in situ. What is carcinoma in situ ... What is papillary urothelial carcinoma?. Papillary urothelial carcinoma forms in the inner lining of the bladder. ... Signs of papillary urothelial carcinoma. Signs and symptoms of papillary urothelial carcinoma are similar to signs and symptoms ...
Il carcinoma squamo-cellulare di Marjolin o ulcera di Marjolin è un tumore maligno della cute che può insorgere raramente in ... Wikimedia Commons contiene immagini o altri file su Carcinoma squamo-cellulare di Marjolin ... Esther RJ, Lamps L, Schwartz HS, Marjolin ulcers: secondary carcinomas in chronic wounds, in J South Orthop Assoc, vol. 8, nº 3 ... Phillips TJ, Salman SM, Bhawan J, Rogers GS, Burn scar carcinoma. Diagnosis and management, in Dermatol Surg, vol. 24, nº 5, ...
... ANSWER This cancer is unlikely to spread from your skin to other parts of your body, but ...
Renal cell carcinoma is rarely detected in the early stages of disease, since there are often no obvious symptoms until the ... Renal cell carcinoma is rarely detected in the early stages of disease, since there are often no obvious symptoms until the ... Some of the steps taken to diagnose renal cell carcinoma include:. *A detailed medical examination is performed and the patient ... Renal Cell Carcinoma Diagnosis. News-Medical, viewed 20 October 2020, https://www.news-medical.net/health/Renal-Cell-Carcinoma- ...
  • Anaplastic carcinoma is a rare but very deadly form of thyroid cancer that can cause severe breathing difficulties. (wisegeek.com)
  • What is Anaplastic Carcinoma? (wisegeek.com)
  • Doctors are unsure what causes anaplastic carcinoma, but several risk factors have been identified. (wisegeek.com)
  • The cancer is most commonly seen in patients over the age of sixty, and women are about three times as likely to develop anaplastic carcinoma as males. (wisegeek.com)
  • In addition, patients who have been diagnosed and treated for other more common types of thyroid disorders, such as goiters and follicular cancer, are more likely to develop anaplastic carcinoma. (wisegeek.com)
  • An oncologist can diagnose anaplastic carcinoma by feeling the neck mass , asking about symptoms, and taking computerized tomography scans of the neck and chest. (wisegeek.com)
  • Treatment decisions are considered immediately after biopsy results reveal anaplastic carcinoma. (wisegeek.com)
  • My mother passed from Anaplastic Carcinoma in December 2013. (wisegeek.com)
  • There is a lot of hopelessness on the internet about this cancer, so I want to mention that it is possible to survive anaplastic carcinoma of the thyroid. (wisegeek.com)
  • turkay1-- My grandmother died from anaplastic thyroid carcinoma and I know from her case that this type of cancer also causes coughing, difficulty breathing and swallowing and a huge lump on the neck. (wisegeek.com)
  • I suppose the lump could be confused with goiter which is not uncommon with hypothyroidism, but the lump from anaplastic carcinoma grows very quickly. (wisegeek.com)
  • Is anaplastic carcinoma seen often in people with hypothyroidism? (wisegeek.com)
  • I have hypothyroidism and if I had anaplastic carcinoma, I think it would be difficult for me to notice because hypothyroidism causes many of these symptoms. (wisegeek.com)
  • Carcinoma of the amjgdala fossa: The information has been completed with other bibliographic sources such as cancer registries and Oncology essays. (hellobmwz4.info)
  • Una variante anaplásica del carcinoma epidermoide, denominada linfoepitelioma en amígdala palatina/lingual, tenían menos probabilidades de aparecer en. (hellobmwz4.info)
  • Se ha llevado a cabo un estudio retrospectivode 34 pacientes con carcinoma epidermoide de la región amigdalina tratados con dos Cáncer de amígdala. (hellobmwz4.info)
  • Abstract It has been carried out a retrospective analysis of 34 patients suffering from carcinoma epidermoid of the tonsillar fossa being treated with two different therapies from to Concomitant boost radiotherapy for squamous carcinoma of the tonsillar fossa. (hellobmwz4.info)
  • Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. (hellobmwz4.info)
  • Mediante el Tratamiento Inmunobiológico Issels y sin necesidad de ningún otro tratamiento convencional, se logró una remisión completa a largo plazo de la tercera recurrencia de un carcinoma cervical avanzado de células escamosas inoperable. (issels.com)
  • Treatment duration as a prognostic factor for local control and survival in epidermoid carcinomas of epjdermoide tonsillar region treated by combined external beam irradiation and brachytherapy. (hellobmwz4.info)
  • Radiation therapy for squamous cell carcinoma of the tonsil. (hellobmwz4.info)
  • Localization of the sentinel lymph node in tongue VX2 carcinoma via indirect CT lymphography combined with methylene blue dye injection. (hellobmwz4.info)
  • Advances in molecular characterization and novel gene-isolation techniques have vigorously expanded our understanding of hepatocellular carcinoma (HCC), a form of liver cancer that affects one million people annually, and generated many new therapeutic possibilities. (springer.com)
  • In Hepatocellular Carcinoma: Methods and Protocols, Nagy Habib and a team of basic and clinical researchers describe the wide variety of powerful new laboratory-based molecular methods currently being used for investigating and treating this disease. (springer.com)
  • Hepatocellular Carcinoma: Methods and Protocols offers experimental and clinical investigators a rich source of both basic science and clinical information on today's optimal use of gene therapy to treat and manage patients suffering from hepatocellular carcinoma. (springer.com)
  • This year the number of papers published regarding hepatocellular carcinoma (HCC) continued to increase compared with last year, coinciding with an increase in incidence and awareness of this tumor. (nih.gov)
  • Liver cancer, primarily hepatocellular carcinoma (HCC), is the third leading cause of death from cancer worldwide and the ninth leading cause of cancer deaths in the United States ( 1,2 ). (cdc.gov)
  • Association between hepatocellular carcinoma (HCC)-related variables and metastasis stratified by total tumour volume (TTV). (medscape.com)
  • The hepatocellular carcinoma (HCC) is one of the most common malignant tumors and carries a poor survival rate. (hindawi.com)
  • In this paper, a summary of most relevant available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was presented. (hindawi.com)
  • Hepatocellular carcinoma (HCC) is one such cancer that can benefit from tumor biomarkers' diagnostic, therapeutic, and prognostic capabilities. (hindawi.com)
  • The first serologic assay for detection and clinical followup of patients with hepatocellular carcinoma was alpha-fetoprotein (AFP) which has been the standard tumor biomarker for HCC for many years. (hindawi.com)
  • On January 14, 2019, the Food and Drug Administration approved cabozantinib (CABOMETYX, Exelixis, Inc.) for patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. (fda.gov)
  • Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. (drugs.com)
  • Hepatocellular carcinoma occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection. (drugs.com)
  • Which treatment is best for you will depend on the size and location of your hepatocellular carcinoma, how well your liver is functioning, and your overall health. (drugs.com)
  • Hepatocellular carcinomas (HCC) are also known as primary liver cancers , hepatic tumors , or hepatomas . (upmc.com)
  • Many people with hepatocellular carcinoma (HCC) have no symptoms until the disease becomes advanced. (upmc.com)
  • The UPMC Liver Cancer Center's multidisciplinary team of experts offers several treatment options for people with hepatocellular carcinoma (HCC). (upmc.com)
  • TriSalus, a Denver, Colorado firm, is launching a new solid tumor infusion system to target hepatocellular carcinoma, liver metastases, and other tumors. (medworm.com)
  • JINAN, China, April 8 -- For large hepatocellular carcinoma tumors, transarterial chemoembolization plus radiofrequency ablation improves survival better than either alone, according to researchers here. (medpagetoday.com)
  • In particular, neither results in adequate control of hepatocellular carcinoma tumors larger than 3 cm. (medpagetoday.com)
  • The exact role for transarterial chemoembolization-radiofrequency ablation in the treatment of patients with unresectable hepatocellular carcinoma remains a controversial and unresolved issue," they wrote, "similar to the situation for many of the interventional-based therapies. (medpagetoday.com)
  • Blood flow to hepatocellular carcinoma lesions can be substantially reduced by the arterial embolization effect of transcatheter arterial chemoembolization treatment. (medpagetoday.com)
  • The 291 consecutive patients with hepatocellular carcinoma larger than 3 cm were randomly assigned to treatment with an emulsion of 50 mg of cisplatin (Platinol) and 10 mL of lipiodol (Lipiocis) followed by embolization with granules of gelatin sponge particles, with RF ablation at a temperature of 100 C, or with both. (medpagetoday.com)
  • Liver Cell Adenoma or Hepatocellular Carcinoma? (medindia.net)
  • Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. (medindia.net)
  • Approximately one-third of renal cell carcinomas have already metastasized by the time of diagnosis. (britannica.com)
  • Retrieved on October 20, 2020 from https://www.news-medical.net/health/Renal-Cell-Carcinoma-Diagnosis.aspx. (news-medical.net)
  • When making a diagnosis of squamous cell carcinoma, it is important to distinguish it from other health conditions with similar symptoms, to ensure the optimal treatment plan is followed. (news-medical.net)
  • Retrieved on January 24, 2020 from https://www.news-medical.net/health/Squamous-Cell-Carcinoma-Diagnosis.aspx. (news-medical.net)
  • Early diagnosis is difficult: precursor lesions to adenocarcinoma in situ are still poorly defined and understood, and there may be a rapid transit time from in situ to invasive carcinoma. (nih.gov)
  • Women with a diagnosis of lobular carcinoma in situ are referred to the High-Risk Breast Cancer Program . (upmc.com)
  • In most patients ( ~ 90%), brain metastasis was detected after diagnosis of endometrial carcinoma with a median interval from diagnosis of endometrial carcinoma to diagnosis of brain metastases of 17 months. (hindawi.com)
  • The differential diagnosis for the right lobe lesion includes cellular adenomatoid nodule, follicular adenoma, follicular carcinoma and follicular variant of papillary carcinoma. (medhelp.org)
  • However, medullary breast carcinoma cells look similar to IDC cells, making accurate diagnosis difficult. (medicalnewstoday.com)
  • People with medullary breast carcinoma who receive an accurate diagnosis and timely treatment typically have a positive outlook. (medicalnewstoday.com)
  • Does anyone else have a diagnosis of mucinous or colloid breast carcinoma? (cancerresearchuk.org)
  • The symptoms of thyroid carcinoma are non-specific, and testing is the only definitive way to acquire an accurate diagnosis. (vetinfo.com)
  • Here we present the case of a 75-year-old patient with ductal infiltrated carcinoma for 3 years, who presented an acute erythematous and infiltrated plaque in the region of a previous mastectomy, with a final diagnosis of EC. (scielo.br)
  • Anyone who is displaying signs of a potential Merkel cell carcinoma recurrence can turn to Moffitt Cancer Center for prompt diagnosis and treatment. (moffitt.org)
  • 3Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Hangzhou, People's Republic of China Abstract: Adenosquamous carcinoma of the lung (ASC), a relatively rare subtype of non-small-cell lung cancer, is defined as a malignancy containing components of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC). (doaj.org)
  • The median age of patients at the diagnosis of endometrial carcinoma is 63 years [8]. (thefreedictionary.com)
  • More effort needs to be spent on the science of how normal human biology differs between men and women and how the diagnosis and treatment of urothelial carcinoma differs as a function of gender," said Dr. Shariat. (medindia.net)
  • Pleomorphic carcinoma contains spindle cell and/or giant cell components, plus at least a 10% component of cells characteristic of more highly differentiated types (i.e. adenocarcinoma and/or squamous cell carcinoma). (wikipedia.org)
  • Invasive ductal carcinoma is also called infiltrating ductal carcinoma or ductal adenocarcinoma. (cancer.ca)
  • Bronchioloalveolar carcinoma (BAC) is a subtype of adenocarcinoma of the lung. (oncolink.org)
  • For carcinoma component, acinar adenocarcinoma is the most common pattern. (auanet.org)
  • spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
  • Most skin cancers, including Merkel cell carcinoma (MCC), are brought to a doctor's attention because of signs or symptoms a person is having. (cancer.org)
  • Renal cell carcinoma is responsible for about 90 percent of kidney cancers in adults. (britannica.com)
  • As with many cancers, the symptoms of renal cell carcinoma are often associated with other disorders. (britannica.com)
  • Unlike many other cancers, renal cell carcinoma generally does not respond well to chemotherapy or radiation . (britannica.com)
  • Basal cell carcinoma (BCC) is the most common and least lethal form of all cancers. (healthcentral.com)
  • Over 90 percent of kidney cancers are renal cell carcinomas (RCC), which start in the tubules of the kidneys. (healthline.com)
  • Endometrial carcinoma in USA is the first most common cancer of the female genital tract, the fourth most common malignancy (after breast, lung, and colorectal cancer) in females accounting for 6% of all cancers in females [ 7 , 8 ]. (hindawi.com)
  • Invasive, or infiltrating, lobular carcinoma accounts for about 10% of all invasive breast cancers. (cancer.ca)
  • As medullary breast carcinomas are less likely than other cancers to spread to the lymph nodes, a doctor may decide to use surgery without any additional, or adjuvant, treatments, such as chemotherapy or radiation therapy . (medicalnewstoday.com)
  • About 10% of all invasive breast cancers are invasive lobular carcinomas. (breastcancer.org)
  • As with most skin cancers, basal cell carcinoma tends to appear on body parts routinely exposed to sun such as the face, neck, shoulders, and scalp. (qualityhealth.com)
  • Merkel cell carcinoma is associated with the development of other skin cancers, such as basal cell or squamous cell carcinoma. (mayoclinic.org)
  • Some of the more well known include the lesions containing pseudo-sarcomatous components: spindle cell carcinoma (containing elongated cells resembling connective tissue cancers), giant cell carcinoma (containing huge, bizarre, multinucleated cells), and sarcomatoid carcinoma (mixtures of spindle and giant cell carcinoma). (wikipedia.org)
  • In this article, we take a look at symptoms, causes, and treatment options for papillary urothelial carcinoma. (medicalnewstoday.com)
  • Renal cell carcinoma is rarely detected in the early stages of disease, since there are often no obvious symptoms until the disease has reached an advanced stage. (news-medical.net)
  • Continue reading this article for more information on medullary breast carcinoma, including its symptoms, causes, treatment, and survival rates. (medicalnewstoday.com)
  • Because these symptoms also occur in common childhood infections, they don't point specifically to nasopharyngeal carcinoma. (childrensnational.org)
  • Biopsy needle size is a factor associated with upstaging of ductal carcinoma in situ. (greenmedinfo.com)
  • Breastcancer.org: "DCIS - Ductal Carcinoma In Situ," "Invasive ductal carcinoma," "Treatment for DCIS. (webmd.com)
  • What is ductal carcinoma in situ? (webmd.com)
  • It may be non-invasive (called ductal carcinoma in situ) or invasive. (cancer.ca)
  • Allolio B, Fassnacht M. Adrenocortical carcinoma. (medlineplus.gov)
  • Adrenocortical carcinoma treatment (Adult) (PDQ) - health professional version. (medlineplus.gov)
  • NCI does not have PDQ evidence-based information about prevention of adrenocortical carcinoma. (cancer.gov)
  • Some radiological features are helpful to distinguish mucinous from nonmucinous gastric carcinomas. (isciii.es)
  • Mucinous versus nonmucinous gastric carcinoma: Differentiation with Helical CT. (isciii.es)
  • Clinicopathologic characteristics and surgical outcomes of mucinous gastric carcinoma. (isciii.es)
  • citation needed] When found within the skin, mucinous carcinoma is commonly a round, elevated, reddish, and sometimes ulcerated mass, usually located on the head and neck. (wikipedia.org)
  • Hakenberg OW, Drager D, Erbersdobler A. Pathology, molecular biology, and prognosis of penile squamous cell carcinoma: what can we learn from the specimen? (springer.com)
  • The pathology and treatment of nasopharyngeal carcinoma are presented elsewhere. (uptodate.com)
  • See 'Pathology of head and neck neoplasms', section on 'Nasopharyngeal carcinoma' . (uptodate.com)
  • Micrograph of a lung primary small cell carcinoma , a type of carcinoma. (wikipedia.org)
  • [7] A history of cigarette smoking is the most common cause of large cell carcinoma. (wikipedia.org)
  • Targeting renal cell carcinoma with a HIF-2 antagonist. (nih.gov)
  • Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL). (nih.gov)
  • The therapeutic potential of HIF-2 antagonism in renal cell carcinoma. (nih.gov)
  • The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate 025 trial. (renalandurologynews.com)
  • In a phase Ib study, dual therapy with axitinib and pembrolizumab was well tolerated and demonstrated antitumor activity in treatment-naïve patients with advanced renal cell carcinoma. (renalandurologynews.com)
  • Study reveals a 38% decreased risk of death in patients with papillary metastatic renal cell carcinoma who undergo cytoreductive nephrectomy vs those who do not. (renalandurologynews.com)
  • Immunotherapy with atezolizumab plus targeted therapy with bevacizumab improves progression-free survival better than sunitinib in patients with untreated metastatic renal cell carcinoma. (renalandurologynews.com)
  • Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma. (renalandurologynews.com)
  • Little is known about the endocannabinoid (eCB) system in squamous cell carcinoma of the oral tongue (SCCOT). (diva-portal.org)
  • [7] Histology may mimic basal cell carcinoma . (wikipedia.org)
  • Having a risk factor for Merkel cell carcinoma (MCC), or even many risk factors, doesn't mean that you will get it. (cancer.org)
  • New and emerging treatments for metastatic Merkel cell carcinoma. (cancer.org)
  • The role of human papillomavirus infection in the pathogenesis of penile squamous cell carcinoma. (springer.com)
  • The role of pathologic prognostic factors in squamous cell carcinoma of the penis. (springer.com)
  • Renal cell carcinoma appears to be caused by both genetic and environmental factors. (britannica.com)
  • Although no laboratory test exists for diagnosing renal cell carcinoma, urinalysis may reveal blood in the urine, and a blood test may reveal anemia, elevated liver enzymes, or elevated calcium levels. (britannica.com)
  • The average five-year survival rate for all stages of renal cell carcinoma combined is more than 60 percent. (britannica.com)
  • Although chemotherapy and radiation treatments are generally not effective in curing renal cell carcinoma, they may be used in conjunction with surgery or in cases where, because of generally poor health , surgery is not indicated. (britannica.com)
  • In addition, targeted therapies, such as temsirolimus and everolimus, may be used to treat advanced renal cell carcinoma, and biological therapies involving the immune system may be used to combat the disease in its various stages. (britannica.com)
  • How does basal cell carcinoma spread? (webmd.com)
  • Medscape: "Basal Cell Carcinoma. (webmd.com)
  • Harvard Health Letter: "Recognizing and treating basal cell carcinoma. (webmd.com)
  • The most common type of basal cell carcinoma is nodular basal cell carcinoma, a flesh-colored (cream to pink), round or oval translucent nodule with overlying small blood vessels and a pearly-appearing rolled border. (healthcentral.com)
  • The main cause of basal cell carcinoma of the skin is ultraviolet radiation from the sun. (healthcentral.com)
  • The five most typical characteristics of basal cell carcinoma are quite different from each other. (healthcentral.com)
  • In addition, basal cell carcinoma sometimes resembles non-cancerous skin conditions, such as psoriasis or eczema. (healthcentral.com)
  • It is advisable to learn the signs of basal cell carcinoma and examine the body regularly, as often as once a month, if at high risk. (healthcentral.com)
  • Patients should be encouraged to regularly check their skin and monitor for any changes that may indicate abnormal cell growth and early signs of squamous cell carcinoma. (news-medical.net)
  • In addition to self-examination by patients, a health professional should be involved in the screening for squamous cell carcinoma, particularly for those individuals at high risk of developing the condition. (news-medical.net)
  • All areas of the skin should then be examined, and suspicious areas looked at more closely for specific characteristics that may suggest squamous cell carcinoma, such as irregularity of shape. (news-medical.net)
  • It may also be necessary to check for enlarged lymph nodes, particularly when there are suspicious spots on the skin that may be caused by squamous cell carcinoma. (news-medical.net)
  • Treatment plans for patients with advanced renal cell carcinoma (RCC) vary, but can often involve both surgery and medicine, and it is not uncommon for patients to be treated with more than one medicine or type of therapy. (novartis.com)
  • Become an ally in the fight against renal cell carcinoma. (novartis.com)
  • squamous cell carcinoma To Dr.Fernando Roque, Sir, I have certain doubts regarding my mother's biopsy and clinical tests. (medhelp.org)
  • She was diagnosed with renal cell carcinoma (RCC) when she was just 30. (sheknows.com)
  • Renal cell carcinoma (RCC) is a diagnostic consideration when a renal mass is found on a radiologic study. (medscape.com)
  • Excruciating, sharp, bandlike back pain may be an early warning for spinal cord compression due to metastatic renal cell carcinoma and should not be ignored. (medscape.com)
  • Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
  • Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. (medscape.com)
  • Chronic hepatitis C infection as a risk factor for renal cell carcinoma. (medscape.com)
  • Robson CJ, Churchill BM, Anderson W. The results of radical nephrectomy for renal cell carcinoma. (medscape.com)
  • Progression-free survival as a predictor of overall survival in metastatic renal cell carcinoma treated with contemporary targeted therapy. (medscape.com)
  • Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A, Ferrara J. Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. (medscape.com)
  • Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: results from a large, multicenter study. (medscape.com)
  • Mutations in four genes appear to play a key role in the origin of renal cell carcinoma. (medpagetoday.com)
  • A mammalian target of rapamycin (mTOR) inhibitor failed to improve outcomes in metastatic renal cell carcinoma (RCC) as compared with other therapeutic options, according to two randomized trials. (medpagetoday.com)
  • Two small-molecule inhibitors proved comparable as first-line therapy for metastatic renal-cell carcinoma (RCC), results of a large randomized trial showed. (medpagetoday.com)
  • The FDA has rejected the oral VEGF receptor tyrosine kinase inhibitor tivozanib, intended for the treatment of renal cell carcinoma, according to the drug's developer. (medpagetoday.com)
  • SILVER SPRING, Md. -- An FDA advisory committee voiced near unanimous disapproval for a novel advanced renal cell carcinoma drug and a drug-device combo to treat unresectable ocular melanoma that is metastatic to the liver. (medpagetoday.com)
  • Metastatic growth of renal cell carcinoma did not increase after completion of treatment with sunitinib (Sutent), alleviating concerns that had arisen in recent animal studies, an analysis of trial findings showed. (medpagetoday.com)
  • VIENNA -- Metastatic renal cell carcinoma responded about as well to the oral targeted agent pazopanib (Votrient) as to oral sunitinib (Sutent), researchers said here. (medpagetoday.com)
  • There is some evidence that radiation therapy can be useful in slowing the progress of squamous cell carcinoma and if that is available in your area, you might consider it. (vetinfo.com)
  • On December 19, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA®, Merck & Co. Inc.) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC). (fda.gov)
  • Squamous cell or oat cell carcinoma that develops in the mucosa of the large bronchi and produces a persistent productive cough or hemoptysis. (dictionary.com)
  • Lung --Squamous cell carcinoma - download at 4shared. (4shared.com)
  • Lung --Squamous cell carcinoma is hosted at free file sharing service 4shared. (4shared.com)
  • The appearance of squamous cell carcinoma is more varied than basal cell carcinoma. (healthcentral.com)
  • Squamous cell carcinoma also tends to grow more quickly and can, unlike basal cell, spread to other parts of the body, making it more dangerous than basal cell carcinoma . (healthcentral.com)
  • What is a squamous cell carcinoma? (pdsa.org.uk)
  • There is a type of squamous cell carcinoma that can develop inside the mouth. (pdsa.org.uk)
  • Well-differentiated squamous cell carcinoma with broad pushing borders rather than the finger-like infiltrative borders of a typical squamous cell carcinoma (image B) . (auanet.org)
  • After treatment, many patients are concerned about a potential Merkel cell carcinoma recurrence. (moffitt.org)
  • If Merkel cell carcinoma does come back, unusual skin changes can often be detected in their earliest stages during follow-up assessments. (moffitt.org)
  • Merkel cell carcinoma survivors are also advised to complete regular self-exams to check for the potential signs of a recurrence. (moffitt.org)
  • There are several different therapies that might be recommended to treat recurrent Merkel cell carcinoma. (moffitt.org)
  • There is no cure for feline squamous cell carcinoma, but with attention and proper treatment, it's possible for a cat to continue for some time with a good quality of life. (vetinfo.com)
  • Treatment options for feline squamous cell carcinoma include many different types of therapy. (vetinfo.com)
  • Medication - since significant pain may be present with feline squamous cell carcinoma, you may need to determine the benefits of each type of medication. (vetinfo.com)
  • Properly caring for a cat with feline squamous cell carcinoma can help to improve quality of life and also help to speed recovery from surgery, chemotherapy or other treatment options that you have decided to pursue. (vetinfo.com)
  • Basal cell carcinoma can sometimes appear similar to skin conditions like eczema or psoriasis. (qualityhealth.com)
  • The difficulty of treating basal cell carcinoma depends on its stage and size. (qualityhealth.com)
  • Renal-cell carcinoma (RCC) is curable only in patients presenting with resectable, early-stage disease. (cancernetwork.com)
  • Renal-cell carcinoma occurs most commonly in adults over the age of 40 years [2,3], but family clustering with younger ages at presentation has been reported [4]. (cancernetwork.com)
  • MSK's squamous cell carcinoma experts, including Mohs surgeon Erica Lee, are focused on your needs and concerns when planning care. (mskcc.org)
  • PRIMARY OBJECTIVES: I. To estimate the prevalence of invasive squamous cell carcinoma of the anus in women with high-grade dysplasia or carcinoma of the cervix, vagina or vulva. (centerwatch.com)
  • Merkel cell carcinoma is also called neuroendocrine carcinoma of the skin. (mayoclinic.org)
  • Merkel cell carcinoma most often develops in older people. (mayoclinic.org)
  • Long-term sun exposure or a weak immune system may increase your risk of developing Merkel cell carcinoma. (mayoclinic.org)
  • Merkel cell carcinoma tends to grow fast and to spread quickly to other parts of your body. (mayoclinic.org)
  • It's not clear what causes Merkel cell carcinoma. (mayoclinic.org)
  • Merkel cell carcinoma begins in the Merkel cells. (mayoclinic.org)
  • Researchers recently discovered that a common virus plays a role in causing most cases of Merkel cell carcinoma. (mayoclinic.org)
  • Just how this virus causes Merkel cell carcinoma has yet to be determined. (mayoclinic.org)
  • Being exposed to ultraviolet light, such as the light that comes from the sun or from tanning beds, increases your risk of Merkel cell carcinoma. (mayoclinic.org)
  • People with weakened immune systems - including those with HIV infection, those taking drugs that suppress the immune response or those with chronic leukemias - are more likely to develop Merkel cell carcinoma. (mayoclinic.org)
  • Your risk of Merkel cell carcinoma increases as you age. (mayoclinic.org)
  • Merkel cell carcinoma usually arises in people who have light-colored skin. (mayoclinic.org)
  • Even with treatment, Merkel cell carcinoma commonly spreads (metastasizes) beyond the skin. (mayoclinic.org)
  • Merkel cell carcinoma tends to travel first to nearby lymph nodes. (mayoclinic.org)
  • This photograph shows a basal cell carcinoma that affects the skin on the lower eyelid. (mayoclinic.org)
  • Basal cell carcinoma begins in the basal cells - a type of cell within the skin that produces new skin cells as old ones die off. (mayoclinic.org)
  • Basal cell carcinoma often appears as a slightly transparent bump on the skin, though it can take other forms. (mayoclinic.org)
  • Basal cell carcinoma occurs most often on areas of the skin that are exposed to the sun, such as your head and neck. (mayoclinic.org)
  • Avoiding the sun and using sunscreen may help protect against basal cell carcinoma. (mayoclinic.org)
  • Basal cell carcinoma usually develops on sun-exposed parts of your body, especially your head and neck. (mayoclinic.org)
  • Basal cell carcinoma appears as a change in the skin, such as a growth or a sore that won't heal. (mayoclinic.org)
  • The most common type of basal cell carcinoma, this lesion often appears on the face, ears or neck. (mayoclinic.org)
  • A white, waxy, scar-like lesion without a clearly defined border, called morpheaform basal cell carcinoma, is the least common. (mayoclinic.org)
  • Basal cell carcinoma occurs when one of the skin's basal cells develops a mutation in its DNA. (mayoclinic.org)
  • Other factors can contribute to the risk and development of basal cell carcinoma, and the exact cause may in some cases not be clear. (mayoclinic.org)
  • My dad has had reaccurring basil cell carcinoma, he has had numrous surgeries and mohs which is currently working. (dailystrength.org)
  • The cause of most squamous cell carcinoma (SCC) of the skin is well known. (aad.org)
  • Spending time in the sun without protecting your skin from the sun greatly increases your risk of developing squamous cell carcinoma of the skin. (aad.org)
  • When mutations develop in skin cells called squamous cells, we get squamous cell carcinoma of the skin. (aad.org)
  • Squamous cell carcinoma Refers to a carcinoma with observable features and characteristics indicative of squamous differentiation (intercellular bridges, keratinization, squamous pearls). (wikipedia.org)
  • Large cell carcinoma Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm. (wikipedia.org)
  • Small cell carcinoma Cells are usually round and are less than approximately 3 times the diameter of a resting lymphocyte and little evident cytoplasm. (wikipedia.org)
  • Most Merkel cell carcinomas appear on the face, head or neck, but they can develop anywhere on your body, even on areas not exposed to sunlight. (mayoclinic.org)
  • The majority of Merkel cell carcinomas appear on skin surfaces frequently exposed to sun. (mayoclinic.org)
  • This paper will focus on knowledge related to brain metastases from endometrial carcinoma. (hindawi.com)
  • It is suggested that brain imaging studies should be considered in the routine follow up of patients with endometrial carcinoma and that the search for a primary source in females with brain metastases of unknown primary should include endometrial biopsy. (hindawi.com)
  • The incidence of brain metastases from ovarian carcinoma (7/335, 2.1%) was higher than those from endometrial carcinoma (4/556, 0.7%), uterine cervix carcinoma (7/1716, 0.4%), and other female genital tract malignancies combined (vagina, vulva, and fallopian tube carcinoma) (0/122, 0%) [ 6 ]. (hindawi.com)
  • The above-mentioned diagnostic and prognostic issues will be addressed in this review using the chapter on follicular carcinoma of the WHO book, 1 not only as a frame but also as a starting point for consolidating the classic criteria and discussing some recently advanced proposals. (nature.com)
  • Follicular Carcinoma is the one my Endocronologist is concerned about. (medhelp.org)
  • Carcinoma admixed with sarcomatoid spindle cells (most common) (image A) , (image B) , & (image C) . (auanet.org)
  • Canine thyroid carcinoma is a common disease found in dogs, and treatments are available. (vetinfo.com)
  • Lobular carcinoma in situ (inside) is classified as a high-risk condition. (upmc.com)
  • This type of carcinoma is commonly managed by local resection , cryotherapy , topical chemotherapy , and radiotherapy . (wikipedia.org)
  • If the squamous carcinoma comes from the lung, gemcitabine is useful, but if it came from some other organ such as the cervix, this chemotherapy may be less effective. (medhelp.org)
  • Secretory carcinoma is slow-growing, so it doesn't always respond well to chemotherapy. (healthline.com)
  • Invasive lobular carcinoma can occur in more than one area of the breast (called multifocal, or multicentric, disease). (cancer.ca)
  • In the primary form, both, carcinoma and inflammatory changes occur simultaneously in a previously normal breast. (scielo.br)
  • Whereas in the secondary form, inflammatory changes occur later in a breast with previous carcinoma. (scielo.br)
  • ILC tends to occur later in life than invasive ductal carcinoma - the early 60s as opposed to the mid- to late 50s. (breastcancer.org)
  • Most basal cell carcinomas are thought to be caused by long-term exposure to ultraviolet (UV) radiation from sunlight. (mayoclinic.org)
  • Follicular thyroid carcinoma is being diagnosed less and less frequently despite the increasing incidence of well-differentiated thyroid carcinomas everywhere. (nature.com)
  • The past two decades have seen an increase in the incidence of endocervical carcinoma. (nih.gov)
  • No specific data are available regarding United States versus international incidence of eccrine carcinoma. (medscape.com)
  • Sex incidence appears to be equal for eccrine carcinoma. (medscape.com)
  • To date, 115 cases were documented in the literature with an incidence of 0.6% among endometrial carcinoma patients. (hindawi.com)
  • Eccrine carcinomas most commonly are diagnosed in patients in their sixth through eighth decades of life. (medscape.com)
  • The utilization of more strict criteria for recognizing capsular and vascular invasion, and the aforementioned trend toward overdiagnosing FVPTC has led, together with the increasing number of PTC diagnoses (namely small or very small lesions), to a progressive reduction in the percentage of FTCs among well-differentiated thyroid carcinomas. (nature.com)
  • Diagnostic problems in precancerous lesions and invasive carcinomas of the penis. (springer.com)
  • Distribution and characterization of subtypes of penile intraepithelial neoplasia and their association with invasive carcinomas: a pathological study of 139 lesions in 121 patients. (springer.com)
  • Radiation should be avoided as it may cause the verrucous carcinoma to dedifferentiate into a highly aggressive spindle cell squamous carcinoma. (auanet.org)
  • These images are a random sampling from a Bing search on the term "Thyroid Carcinoma. (fpnotebook.com)
  • I did a search for Ductal Carcinoma and one of the hits was a letter from Jayna. (meds.com)
  • When used as the primary treatment modality for sebaceous carcinoma of the eyelid, Mohs surgery is associated with significantly lower local and distant recurrence rates. (wikipedia.org)
  • To evaluate the gender-specific effects of smoking habits and cumulative smoking exposure on the health of patients with urothelial carcinoma, investigators led by Shahrokh Shariat, MD, of the Weill Medical College of Cornell University and New York-Presbyterian Hospital in New York City, studied 864 patients (553 men and 311 women) from five international institutions who underwent surgery to treat urothelial carcinoma. (medindia.net)
  • Clinical: Rare, accounts ~4% of penile carcinoma. (auanet.org)
  • The landmark study GOG 33 described the patterns of spread in endometrial carcinoma and concluded that clinical staging is inaccurate as 22% of clinical stage I patients were assigned a higher surgical stage [1]. (thefreedictionary.com)
  • It differs from other head and neck squamous cell carcinomas in epidemiology, histology, natural history, and response to treatment. (uptodate.com)
  • Glans resurfacing for precancerous and superficially invasive carcinomas of the glans penis. (springer.com)
  • Invasive lobular carcinoma is characterized when the mutated cells spread from the lobules into the breast tissue. (upmc.com)
  • In lobular carcinoma, lumps are uncommon and may be difficult to detect by breast exam or mammogram. (upmc.com)
  • Ductal carcinoma starts in gland cells in the breast ducts. (cancer.ca)
  • Invasive ductal carcinoma starts in the breast ducts, grows through the duct wall and grows into nearby breast tissue. (cancer.ca)
  • Invasive lobular carcinoma starts in the lobules, and then grows through the lobules and into nearby breast tissue. (cancer.ca)
  • A carcinoma composed predominantly of anaplastic cells resembling those of apocrine epithelium, often found in the breast. (dictionary.com)
  • Several proteomics technologies including 2D-PAGE, 2D-DIGE, ICAT, SELDI-TOF, MudPIT and protein arrays have been used to uncover molecular mechanisms associated with breast carcinoma at the global level, and a number of these technologies, particularly the SELDI-TOF hold promise as a proteomic approach that can be applied at the bedside for discovering protein patterns that distinguish disease and disease-free states with high sensitivity and specificity. (nih.gov)
  • This review describes proteomics technologies, and their application in the proteomic analysis of breast carcinoma. (nih.gov)
  • Advances in gene transfer technology have greatly expanded the opportunities for developing immunotherapy strategies for breast carcinoma. (biomedcentral.com)