Carcinoid Heart Disease
Malignant Carcinoid Syndrome
Tricuspid Valve Stenosis
Tricuspid Valve Insufficiency
Heart Valve Diseases
Carcinoid heart disease from ovarian primary presenting with acute pericarditis and biventricular failure. (1/47)A case is described of a 54 year old woman who had acute pericarditis with large exudative effusion accompanied by severe right and left ventricular failure. The patient was finally diagnosed with carcinoid heart disease from an ovarian carcinoid teratoma. She was treated with octreotide--a somatostatin analogue--followed by radical surgical resection of the neoplasm. At one year follow up only mild carcinoid tricuspid regurgitation remained. Only 16 cases of carcinoid heart disease from an ovarian primary have been described in literature. Moreover clinically manifest acute, nonmetastatic pericarditis and left heart failure are not considered as possible presentations of carcinoid heart disease, whatever the origin. In a recent series a small pericardial effusion was considered an infrequent and unexpected echocardiographic finding in carcinoid heart patients. One case of "carcinoid pericarditis" has previously been described as a consequence of pericardial metastasis. Left sided heart involvement is usually caused by bronchial carcinoids or patency of foramen ovale; both were excluded in the case presented. (+info)
Balloon pulmonary valvuloplasty in carcinoid syndrome. (2/47)Half of all patients with carcinoid syndrome develop cardiac involvement. Patients who have cardiac involvement have a significantly worse prognosis than those without, and death can occur directly as a result of cardiac involvement. A case of carcinoid syndrome in a 38 year old woman with lesions in the liver, who presented with right sided valvar abnormalities, a dilated right ventricle, and right ventricular pressure overload, is presented. In order to palliate the patient's symptoms and to decrease right sided pressures before major abdominal surgery, balloon pulmonary valvuloplasty was performed at the time of cardiac catheterisation. This resulted in a reduction in the pulmonary gradient and right ventricular pressure. Following the procedure, the patient's symptoms were completely relieved. She went on to laparotomy where the lesions in the liver were excised without complication. (+info)
Tricuspid and pulmonary valve involvement in carcinoid disease. (3/47)We report the case of a 62-year-old woman in whom carcinoid disease had been diagnosed 6 years earlier. She subsequently developed tricuspid and pulmonary valve disease. Both valves were incompetent and mildly stenotic. The tricuspid valve required surgery; the pulmonary vaive was explored but not treated. Valve surgery in patients with carcinoid disease is discussed in light of the prognosis of these patients, the timing of valvular lesion presentation, and the choice of prosthesis. The justification for multiple-valve procedures in such cases is also considered. (+info)
Perianaesthetic risks and outcomes of abdominal surgery for metastatic carcinoid tumours. (4/47)Patients with metastatic carcinoid tumours often undergo surgical procedures to reduce the tumour burden and associated debilitating symptoms. These procedures and anaesthesia can precipitate a life-threatening carcinoid crisis. To assess perioperative outcomes, we studied retrospectively the medical records of adult patients from 1983 to 1996 who underwent abdominal surgery for metastatic carcinoid tumours. Preoperative risk factors, intraoperative complications and complications occurring in the 30 days after surgery were recorded. Perioperative complications or death occurred in 15 of 119 patients (12.6%, exact confidence interval 7.2-19.9). None of the 45 patients who received octreotide intraoperatively experienced intraoperative complications compared with eight of the 73 patients (11.0%) who did not receive octreotide (P=0.023). The presence of carcinoid heart disease and high urinary output of 5-hydroxyindoleacetic acid preoperatively were statistically significant risk factors for perioperative complications. (+info)
Surgical management of left-sided carcinoid heart disease. (5/47)BACKGROUND: Carcinoid involvement of left-sided heart valves has been reported in patients with a patent foramen ovale, carcinoid tumor of the lung, and active carcinoid syndrome with high levels of serotonin. The present study details the clinical features and surgical management of patients with carcinoid heart disease affecting both left- and right-sided valves. METHODS AND RESULTS: Eleven patients (7 men, 4 women) with symptomatic carcinoid heart disease underwent surgery for left- and right-sided valve disease between 1989 and 1999. Mean age was 57+/-9 years, and median preoperative NYHA class was 3. All patients had metastatic carcinoid tumors and were on somatostatin analog. Of 11 patients, 5 (45%) had a patent foramen ovale; 1 of these also had a primary lung carcinoid tumor. Surgery included tricuspid valve replacement in all patients, pulmonary valve replacement in 3 and valvectomy in 7, mitral valve replacement in 6 and repair in 1, aortic valve replacement in 4 and repair in 2, CABG in 2, and patent foramen ovale closure in 5. One myocardial metastatic carcinoid tumor was removed. There were 2 perioperative deaths. At a mean follow-up of 41 months, 4 additional patients were dead. All but 1 surgical survivor initially improved >/=1 functional class. No patient required reoperation. CONCLUSIONS: Carcinoid heart disease may affect left- and right-sided valves and occurred without intracardiac shunting in 55% of this surgical series. Despite metastatic disease that limits longevity, operative survivors had improvement in functional capacity. Cardiac surgery should be considered for select patients with carcinoid heart disease affecting left- and right-sided valves. (+info)
Carcinoid heart disease: successful tricuspid valve replacement. (6/47)A woman aged 46 was found to have severe tricuspid valve disease 14 years after the diagnosis of a malignant carcinoid tumour of the ileum and 33 years after the onset of symptoms attributable to the disease. Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery. The tricuspid valve was replaced by a Bjork-Shiley prosthesis. After operation there was no recurrence of ascites or oedema. She remains well one year and 11 months later. It is suggested that valve replacement surgery should be considered more often in patients with carcinoid heart disease. Hepatomegaly and ascites sould not be attributed too readily to advancing malignant disease without careful consideration of the role of right-sided valvar lesions in the production of these signs. (+info)
Cardiovascular abnormalities in patients with a carcinoid syndrome. (7/47)BACKGROUND: Heart failure is an important reason for morbidity and mortality in patients with carcinoid. Carcinoid heart disease is caused by increased levels of circulating serotonin. Because carcinoids also produce catecholamines, we evaluated cardiovascular manifestations of autonomic dysfunction in patients with a carcinoid syndrome. METHODS: Twenty patients with a midgut carcinoid, who had a carcinoid syndrome with a median duration of 72 months, and markedly elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) excretion were studied. RESULTS: Ten patients had no symptoms of heart failure, i.e. New York Heart Association (NYHA) functional class I, 6 had class II, and 4 class III heart failure. Transthoracic echocardiography (TTE) showed right-sided valvular abnormalities in 13 of 19 evaluable patients (mild n=8, severe n=5). Fourteen of the 20 patients (70%) had an elevated concentration of plasma N-terminal atrial natriuretic peptide (N-ANP), which correlated with NYHA class, TTE abnormalities, and increased urinary metanephrine excretion. Heart rate variability (HRV) parameters, in particular those associated with increased sympathetic activity (low frequency power, p=0.002 versus healthy individuals), were impaired but were independent of NYHA class and TTE findings and correlated with urinary metanephrine excretion (r=-0.49, p<0.05). CONCLUSION: In these 20 carcinoid patients with substantial secretory activity of the tumour, overt cardiac morphological changes were present in a minority of patients. However, N-ANP values and HRV profile were markedly abnormal, and related to enhanced urinary excretion of catecholamine and metabolites, suggesting autonomic derangement. These abnormalities possibly herald the development of more severe cardiac dysfunction and may be indicative of the need for preventive drug treatment. (+info)
Echocardiographic diagnosis in carcinoid heart disease. (8/47)In this case report the typical echocardiographic features of carcinoid heart disease are presented. Newer treatments such as the use of a somatostatin analogue, interferon and hepatic de-arterialisation have improved the prognosis in patients with carcinoid syndrome. Nevertheless this syndrome portends a poor prognosis in patients with cardiac involvement. Cardiac lesions are mainly located in the right side of the heart. Regurgitation and stenosis of the tricuspid and pulmonary valve, leading to right heart failure, are the most common cardiac manifestations of the disease. Elevated levels of serotonin are probably responsible for the development of these cardiac lesions. Despite treatment resulting in significant reductions of urinary levels of 5-HIAA, regression of the cardiac manifestations in carcinoid syndrome has not been observed. Two-dimensional and Doppler echocardiography are the main tools to establish the diagnosis and severity of carcinoid heart disease. Cardiac surgery for carcinoid heart disease might improve symptoms and longevity, but the scarce data report on early mortality of over 35%. (+info)
Carcinoid heart disease is caused by the release of hormones and other chemicals from the carcinoid tumor into the bloodstream. These substances can cause damage to the heart muscle and blood vessels, leading to a range of symptoms including:
* Shortness of breath
* Swelling in the legs, ankles, and feet (edema)
* Pain in the chest or abdomen
* Rapid or irregular heartbeat (arrhythmia)
* Coughing up blood (hemoptysis)
Carcinoid heart disease can lead to serious complications such as heart failure, atrial fibrillation, and pulmonary embolism. Diagnosis of carcinoid heart disease typically involves a combination of physical examination, medical history, imaging tests (such as CT or MRI scans), and laboratory tests (such as measurements of hormone levels in the blood).
Treatment for carcinoid heart disease depends on the underlying cause of the condition and may include:
* Medications to control symptoms such as shortness of breath, fatigue, and rapid heartbeat
* Chemotherapy or other treatments to shrink the carcinoid tumor
* Surgery to remove the tumor or repair damaged blood vessels
* Radiation therapy to destroy cancer cells.
Prognosis for patients with carcinoid heart disease depends on several factors, including the size and location of the tumor, the extent of damage to the heart and blood vessels, and the patient's overall health. In general, early detection and treatment of carcinoid heart disease can improve outcomes and reduce the risk of complications.
The main symptoms of MCS include:
1. Diarrhea: One of the most common symptoms of MCS is diarrhea, which can be severe and watery.
2. Flushing: A characteristic flushing of the face, neck, and rest of the body, often accompanied by a feeling of warmth.
3. Abdominal pain: Pain in the abdomen is common, particularly if the tumor has spread to other organs.
4. Weight loss: MCS can lead to weight loss due to decreased appetite and malabsorption.
5. Fatigue: Patients with MCS often experience fatigue, which can be severe.
6. Nausea and vomiting: These symptoms are common in patients with MCS.
7. Shortness of breath: If the tumor has spread to the lungs, shortness of breath may occur.
8. Coughing up blood: This is a rare but serious complication of MCS.
The diagnosis of MCS is based on a combination of clinical symptoms, laboratory tests, and imaging studies. Treatment options for MCS include chemotherapy, targeted therapy, and somatostatin analogs, which are medications that can help reduce the symptoms of the syndrome.
In conclusion, malignant carcinoid syndrome is a rare but serious condition that can cause a range of symptoms, including diarrhea, flushing, abdominal pain, weight loss, fatigue, nausea and vomiting, shortness of breath, and coughing up blood. Early diagnosis and treatment are crucial to improve the prognosis for patients with MCS.
Carcinoid tumors are usually found in the appendix, small intestine, rectum, or other parts of the gastrointestinal tract. They can also occur in the lungs, pancreas, or other organs. These tumors tend to grow slowly and often do not cause any symptoms until they have grown quite large.
Carcinoid tumors are diagnosed through a combination of imaging tests such as CT scans, MRI scans, and endoscopies, along with a biopsy to confirm the presence of cancer cells. Treatment for carcinoid tumors depends on the location, size, and stage of the tumor, as well as the patient's overall health. Treatment options may include surgery, chemotherapy, radiation therapy, or a combination of these.
Some of the symptoms that may be associated with carcinoid tumors include:
* Flushing (redness and warmth of the skin)
* Shortness of breath
* Abdominal pain
* Weight loss
Carcinoid tumors are relatively rare, accounting for only about 1% to 5% of all cancer cases. However, they tend to be more common in certain parts of the world, such as North America and Europe. The exact cause of carcinoid tumors is not known, but they are thought to be linked to genetic mutations that occur during fetal development.
Overall, while carcinoid tumors are rare and can be challenging to diagnose and treat, advances in medical technology and cancer research have improved the outlook for patients with these types of tumors. With early detection and appropriate treatment, many people with carcinoid tumors can achieve long-term survival and a good quality of life.
The symptoms of TVS may include:
1. Shortness of breath
3. Swelling in the legs, ankles, and feet
4. Chest pain
5. Dizziness or lightheadedness
6. Pale or blue-tinged skin
7. Fast or irregular heartbeat
If TVS is suspected, a doctor may perform a physical examination, take a medical history, and order diagnostic tests such as:
1. Chest X-ray
2. ECG (electrocardiogram)
3. Echocardiogram (echo)
4. Cardiac MRI
5. Cardiac catheterization
Treatment options for TVS may include:
1. Medications to manage symptoms and slow disease progression, such as diuretics, beta blockers, and ACE inhibitors.
2. Balloon valvuloplasty or valve replacement surgery, which can help to widen the tricuspid valve and improve blood flow.
3. Heart transplantation, which may be considered for patients with severe TVS who are not candidates for other treatments.
It is important to note that TVS is a relatively rare condition compared to other cardiac conditions, but it can be associated with other congenital heart defects or acquired heart diseases. A thorough evaluation by a cardiologist or cardiac surgeon is necessary for proper diagnosis and treatment.
There are several causes of tricuspid valve insufficiency, including:
1. Congenital heart defects: Tricuspid valve insufficiency can be present at birth due to abnormal development of the tricuspid valve.
2. Rheumatic fever: This is an inflammatory condition that can damage the tricuspid valve and lead to insufficiency.
3. Endocarditis: Bacterial infection of the inner lining of the heart, including the tricuspid valve, can cause damage and lead to insufficiency.
4. Heart failure: As the heart fails, the tricuspid valve may become less effective, leading to insufficiency.
5. Cardiac tumors: Tumors in the heart can put pressure on the tricuspid valve and cause insufficiency.
6. Congenital heart disease: Tricuspid valve insufficiency can be present at birth due to abnormal development of the tricuspid valve.
7. Chronic pulmonary disease: This can lead to increased pressure in the right side of the heart, causing tricuspid valve insufficiency.
Symptoms of tricuspid valve insufficiency may include fatigue, shortness of breath, swelling in the legs and feet, and chest pain. Diagnosis is typically made through echocardiography, electrocardiography, and cardiac catheterization.
Treatment options for tricuspid valve insufficiency depend on the severity of the condition and may include:
1. Medications: Diuretics, ACE inhibitors, and beta blockers may be used to manage symptoms and slow progression of the disease.
2. Surgery: In severe cases, surgical repair or replacement of the tricuspid valve may be necessary.
3. Transcatheter tricuspid valve replacement: This is a minimally invasive procedure in which a new tricuspid valve is inserted through a catheter in the femoral vein and placed in the heart.
4. Watchful waiting: In mild cases, doctors may choose to monitor the condition closely without immediate treatment.
There are several types of heart valve diseases, including:
1. Mitral regurgitation: This occurs when the mitral valve does not close properly, allowing blood to flow backward into the left atrium.
2. Aortic stenosis: This occurs when the aortic valve becomes narrowed or blocked, restricting blood flow from the left ventricle into the aorta.
3. Pulmonary stenosis: This occurs when the pulmonary valve becomes narrowed or blocked, restricting blood flow from the right ventricle into the pulmonary artery.
4. Tricuspid regurgitation: This occurs when the tricuspid valve does not close properly, allowing blood to flow backward into the right atrium.
5. Heart valve thickening or calcification: This can occur due to aging, rheumatic fever, or other conditions that cause inflammation in the heart.
6. Endocarditis: This is an infection of the inner lining of the heart, which can damage the heart valves.
7. Rheumatic heart disease: This is a condition caused by rheumatic fever, which can damage the heart valves and cause scarring.
8. Congenital heart defects: These are heart defects that are present at birth, and can affect the heart valves as well as other structures of the heart.
Symptoms of heart valve disease can include shortness of breath, fatigue, swelling in the legs or feet, and chest pain. Treatment options for heart valve disease depend on the specific condition and can range from medication to surgery or other procedures.
Valvular heart disease
Barry A. Love
Jonathan L. Halperin
Pulmonary valve stenosis
Atrial septal defect
List of MeSH codes (C04)
Deaths in May 2014
Small intestine neuroendocrine tumor
Tricuspid valve stenosis
List of pathology mnemonics
Mitral valve replacement
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Deaths in August 2018
List of ICD-9 codes 140-239: neoplasms
Cancer signs and symptoms
List of diseases (C)
List of skin conditions
List of OMIM disorder codes
Clement Price Thomas
List of syndromes
Deaths in October 2011
Alcohol flush reaction
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Telotristat ethyl: a new option for the management of carcinoid syndrome - PubMed
Telotristat ethyl: a new option for the management of carcinoid syndrome - PubMed
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MESH TREE NUMBER CHANGES - 2008 MeSH
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Flashcards - Path Block 3 (GIe)
Medifocus Guidebook on Carcinoid Tumors
Frank Seghatol-Eslami - Research output - Research Profiles at Washington University School of Medicine
Carcinoid Tumor of the Appendix in an Adolescent Female
Instructions for Classification of Underlying and Multiple Causes of Death - Section III - 2019
Toronto, ON, CA
Mitral Valve Disease | Baylor Scott & White Heart and Vascular Hospital - Fort Worth
MESH TREE NUMBER CHANGES - 2008 MeSH
DR. VIDHYA RAJEEV JAHAGIRDAR M.B.B.S, MRCP-UK (INTERNAL MEDICINE) MRCP(DIABETES & ENDOCRINOLOGY)
- Chromogranin A (CgA) as a biomarker in carcinoid heart disease and NETG1/G2 neuroendocrine neoplasms of the small intestine (SI-NENs) related carcinoid syndrome. (bvsalud.org)
- Progression of carcinoid syndrome (CS) to carcinoid heart disease (CHD) is difficult to predict. (bvsalud.org)
- Telotristat ethyl is a tryptophan hydroxylase inhibitor, developed for the treatment of carcinoid syndrome. (nih.gov)
- Areas covered: This review summarises the evidence supporting the role of telotristat ethyl in the management of carcinoid syndrome. (nih.gov)
- 1. The tricuspid valve in carcinoid syndrome. (nih.gov)
- 2. [Echocardiographic detection of tricuspid insufficiency in carcinoid heart syndrome - case report]. (nih.gov)
- 3. [The echocardiogram in the carcinoid heart syndrome. (nih.gov)
- 11. [Tricuspid and pulmonary percutaneous valvulopathy in the cardiopathy of the carcinoid syndrome. (nih.gov)
- 15. Oat cell carcinoma of the bronchus and the carcinoid syndrome. (nih.gov)
- 18. Carcinoid heart disease without the carcinoid syndrome but with quadrivalvular regurgitation and unsuccessful operative intervention. (nih.gov)
- 20. [Atypical presentation of a carcinoid syndrome]. (nih.gov)
- In patients with carcinoid syndrome, endomyocardial fibrosis may lead to obstruction of RV inflow, resulting in a clinical presentation similar to that of TS. (medscape.com)
- Neuroendocrine tumors of the small intestine are the most common causes of the carcinoid syndrome. (eur.nl)
- Carcinoid heart disease occurs in more than half of the patients with the carcinoid syndrome. (eur.nl)
- Treatment with long-acting somatostatin analogs aims at controlling the excessive hormonal output and symptoms related to the carcinoid syndrome and at preventing a carcinoid crisis during interventions. (eur.nl)
- The medications prescribed by my primary physician masked symptoms we now recognize are related to carcinoid syndrome. (carcinoid.org)
- Carcinoid tumors represent the largest number of neuroendocrine tumors and pose a significant challenge to the clinician because they produce a unique clinical syndrome. (parkinsonsdisease-guidebook.com)
- Over the years it became clear that carcinoid tumors can be quite aggressive, can metastasize, and can cause carcinoid syndrome . (parkinsonsdisease-guidebook.com)
- A detailed overview of a condition known as carcinoid syndrome that describes a combination of symptoms that result from hormone-like substances, such as serotonin, gastrin, and ACTH, that are produced by some carcinoid tumors. (parkinsonsdisease-guidebook.com)
- The relationship between carcinoid syndrome and carcinoid heart disease - a condition that affects the heart valves and results in inefficient pumping of blood from the heart to other areas of the body. (parkinsonsdisease-guidebook.com)
- A comprehensive discussion of the relationship between an inherited condition called Multiple Endocrine Neoplasm Syndrome, Type 1 and the risk for developing certain types of carcinoid tumors. (parkinsonsdisease-guidebook.com)
- The histopathologic features were similar to those observed in carcinoid-induced valvular disease, a serotonin-related syndrome. (cdc.gov)
- 13. [Isolated carcinoid tumor of the ovary disclosed by tricuspid insufficiency]. (nih.gov)
- Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. (nih.gov)
- The age at diagnosis varies somewhat among specific tumor locations but typically, most people diagnosed with carcinoid tumor are in their 50s. (parkinsonsdisease-guidebook.com)
- The most common site of carcinoid tumor occurrence for men is in the small intestines and the appendix for women. (parkinsonsdisease-guidebook.com)
- If you or a loved one has been diagnosed with a carcinoid tumor, it's critical to learn everything you possibly can about this condition so that you can make informed decisions about your treatment. (parkinsonsdisease-guidebook.com)
- The risk factors that can increase a person's chances for developing a carcinoid tumor. (parkinsonsdisease-guidebook.com)
- Carcinoid tumor is the most common tumor of the appendix. (jscimedcentral.com)
- Nassif D, Sethuraman U (2016) Carcinoid Tumor of the Appendix in an Adolescent Female. (jscimedcentral.com)
- Locally advanced cancer seen in patients with primary tumors 5cm (T3 lesion), fixed or matted axillary nodes (N2 disease), primary tumor fixed to the chest wall (T4 lesion) and inflammatory breast cancer. (absitereview.com)
- Surgical history includes a small bowel resection for ileal carcinoid tumor with metastasis to the liver and hepatic arterial embolization 16 years prior. (rroij.com)
- Neuroendocrine tumors (NETs) include both carcinoid tumors and pancreatic endocrine tumors (PETs). (parkinsonsdisease-guidebook.com)
- Because the majority of neuroendocrine tumors of the pancreas and carcinoid tumors that involve the wall of the gut have similar biological characteristics, the approach to diagnosis and treatment can be applied broadly to all classes of NETs. (parkinsonsdisease-guidebook.com)
- There are many types of tumors that arise from the neuroendocrine system of which carcinoid tumors are the most common. (parkinsonsdisease-guidebook.com)
- Carcinoid tumors were initially identified in 1888 and were thought to clinically and histologically (cellular appearance under a microscope) resemble carcinoma cells (highly malignant cancer cells) but behave in a more benign fashion than true cancer cells. (parkinsonsdisease-guidebook.com)
- Most carcinoid tumors are now known to be slow growing malignant tumors that have their own specific biological and clinical characteristics. (parkinsonsdisease-guidebook.com)
- Carcinoid tumors are in general quite rare and occur in approximately 2.5-5 per 100,000 people. (parkinsonsdisease-guidebook.com)
- It is probable that more people may actually have carcinoid tumors but because carcinoids are often asymptomatic, an individual may never know that a carcinoid has developed. (parkinsonsdisease-guidebook.com)
- Carcinoid tumors are more prevalent among African-American males (approximately 4.5 per 100,000 people) than among Caucasian males (approximately 2.5 per 100,000 people). (parkinsonsdisease-guidebook.com)
- That's why we created the Medifocus Guidebook on Carcinoid Tumors , a comprehensive 166 page patient Guidebook that contains vital information about carcinoid tumors that you won't find anywhere in a single source. (parkinsonsdisease-guidebook.com)
- The underlying causes of carcinoid tumors. (parkinsonsdisease-guidebook.com)
- Carcinoid tumors arise from neuroendrocrine cells in the foregut, midgut and hindgut with the midgut being the most common site for these tumors. (jscimedcentral.com)
- It is estimated that carcinoid tumors have a prevalence worldwide among all population of 1 to 2 per 100,000 although it may be higher as many cases are asymptomatic and may go unnoticed [3,4]. (jscimedcentral.com)
- Neuroendocrine tumors (NET) are considered to be a rare disease although the frequency of diagnosis has increased over the last ten years. (nanets.net)
- Surgical treatment remains the standard of care, but tricuspid valve disease continues to have one of the highest death rates among all cardiac valve-related procedures, and a broad range of patients still do not receive effective therapy for tricuspid valve disease in contemporary clinical practice. (medscape.com)
- [ 6 ] Echocardiography permits assessment of the dimensions of cardiac chambers, determination of RV and pulmonary pressures, and delineation of associated valvular diseases. (medscape.com)
- Computed tomography (CT) scans of the heart are rarely needed to delineate structural cardiac abnormalities. (medscape.com)
- The tricuspid valve has always been considered less relevant than the left-side valves of the heart, but this "forgotten valve" still represents a great challenge for cardiac surgeons, especially in the most difficult symptomatic scenarios. (medscape.com)
- Interventional cardiologists and cardiac surgeons on the medical staff treat both degenerative mitral valve disease and functional mitral valve conditions. (bswhealth.com)
- These services may include cardiac 3-D computed tomography (CT), cardiac 3-D imaging, cardiac echo, cardiac MRI, heart catheterization, pulmonary function testing (PFT), and vascular ultrasound. (bswhealth.com)
- Because symptoms frequently occur relatively late during the course of valvular incompetence, the prevalence of valve lesions was assessed for patients who were exposed to these drugs but who had no obvious history of cardiac disease or cardiac symptoms. (cdc.gov)
- Combined cardiac valvular disease and pulmonary hypertension appear to occur frequently in patients receiving fen-phen, and more autopsy cases of patients with a history of fen-phen usage are warranted to document the frequency of combined cardiac valvular disease and pulmonary hypertension in the United States. (the-medical-dictionary.com)
- Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. (harvard.edu)
- Aortic Valve Calcium in Relation to Subclinical Cardiac Dysfunction and Risk of Heart Failure. (harvard.edu)
- This may result from CONGENITAL HEART DEFECTS , predisposing heart diseases, complications of surgery, or HEART NEOPLASMS . (nih.gov)
- The guidelines were presented at the European Society of Cardiology (ESC) Congress 2022 on August 27, and published simultaneously in the European Heart Journal . (medscape.com)
- Medical history included moderate ischemic heart disease. (rroij.com)
- CgA has potential as a clinically useful biomarker in reporting disease status and predicting outcome in patients with CS and with CHD. (bvsalud.org)
- Therefore, several alternative, less-invasive technologies for treating patients with severe, native tricuspid valve disease at high surgical risk have been developed, with promising early results. (medscape.com)
- Most patients with rheumatic tricuspid valve disease present with TR or a combination of stenosis and regurgitation. (medscape.com)
- These tests provide assistance with timing and guidance during intervention for patients with tricuspid valve disease. (medscape.com)
- [ 7 , 10 ] Patients who present with congestive heart failure may require assessment of tricuspid valve and LV function through a first-pass technique (ie, multiple-gated acquisition [MUGA] scanning). (medscape.com)
- Tricuspid valve disease affects millions of patients worldwide. (medscape.com)
- The 2020 American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines for the Management of Patients With Valvular Heart Disease provide recommendations for clinicians to diagnose and manage valvular heart disease, as well as supporting documentation. (medscape.com)
- In evaluating patients with valvular heart disease, findings on history and physical examination should be correlated with the results of noninvasive tests (ie, ECG, chest x-ray, transthoracic echocardiogram). (medscape.com)
- Patients with carcinoid heart disease who need to undergo surgery should also undergo preoperative evaluation by an expert cardiologist. (eur.nl)
- Specific issues for carcinoid patients, such as carcinoid crisis and carcinoid heart disease, are addressed. (carcinoid.org)
- BARCELONA - Cardiovascular disease risk factors, as well as established disease, in patients undergoing cancer therapy can be safely managed to minimize cancer therapy-related cardiovascular toxicity (CVR-CVT), conclude the first cardio-oncology guidelines from the European Society of Cardiology. (medscape.com)
- It is through convening professionals in the areas of oncology, gastroenterology, pulmonology, surgery, radiology and allied fields that the awareness and understanding of NET diseases will expand, resulting in better treatment for NET patients. (nanets.net)
- The Mitral Valve Disease Program in Fort Worth, part of the Valve Disorders Center , treats heart patients with mitral valve disease, including mitral stenosis, mitral regurgitation and mitral valve prolapse. (bswhealth.com)
- Advanced diagnostic testing and imaging services for patients with mitral valve heart conditions allow physicians to develop a personalized diagnostic and treatment plan. (bswhealth.com)
- Carcinoid Heart Disease in Patients with Advanced Midgut NETs - E. (cor2ed.com)
- Dapagliflozin and All-Cause Hospitalizations in Patients With Heart Failure With Preserved Ejection Fraction. (harvard.edu)
- ECG-guided non-invasive estimation of pulmonary congestion in patients with heart failure. (harvard.edu)
- and 4) access to information related to rare diseases for basic and clinical researchers, academic and practicing physicians, patients, and the lay public. (nih.gov)
- 4. [The tricuspid valve in carcinoid cardiopathy: characteristic echocardiographic aspects]. (nih.gov)
- 10. Quadruple valve involvement in a patient with severe carcinoid heart disease. (nih.gov)
- 16. Tricuspid and mitral valve carcinoid disease in the setting of a patent foramen ovale. (nih.gov)
- Tricuspid valve disease, particularly tricuspid regurgitation, is a highly prevalent condition with a complex pathophysiology and long-term adverse consequences. (medscape.com)
- Although historically neglected, tricuspid valve disease has gained increasing recognition, with important advances in assessment and management of this disorder since the year 2000. (medscape.com)
- Tricuspid valve disease involves the atrioventricular valve apparatus that separates the right atrium (RA) from the right ventricle (RV). (medscape.com)
- Isolated tricuspid valve disease is rare. (medscape.com)
- Rheumatic TS does not occur as an isolated lesion, but it often accompanies mitral and aortic valve disease. (medscape.com)
- Carcinoid heart disease (tricuspid valve insufficiency). (freezingblue.com)
- Mitral valve disease intervention at the earliest stage of the heart condition is important. (bswhealth.com)
- Early intervention for mitral valve disease could also reduce the risk of stroke for the heart patient. (bswhealth.com)
- Although valvular lesions were observed on both sides of the heart, a left-sided valve was affected in all cases. (cdc.gov)
- Heart valve damage and pulmonary hypertension, severe enough to cause permanent disability or death have been seen with phentermine alone. (the-medical-dictionary.com)
- She was awarded The Society for Endocrinology Clinical Trust Research Fellowship and obtained a PhD in Professor Newell-Prices' laboratory, focussing on RNA interference as a Therapy for Cushing's Disease, leading to a patent and orphan drug designation. (cor2ed.com)
- Department of Clinical Biochemistry (Vascular Disease Prevention Clinic), Royal Free Hospital and Royal Free University College Medical School, London, UK. (hellenicjcardiol.com)
- Clinical profiling of end-stage heart failure with preserved ejection fraction: The National Readmission Database. (harvard.edu)
- Clinical data management for efficient data collection as well as data mining and data sharing across rare diseases will be addressed in the DMCC application. (nih.gov)
- This Funding Opportunity Announcement (FOA) invites applications for the Rare Diseases Clinical Research Consortia (RDCRC) component of the Rare Diseases Research Network (RDCRN). (nih.gov)
- Clinical data management for efficient data collection as well as data mining and data sharing will be addressed through the Data Management and Coordinating Center (DMCC) component of the Rare Diseases Clinical Research Network (RDCRN). (nih.gov)
- Many recommendations from earlier valvular heart disease guidelines have been updated with new evidence and newer options for diagnosis and treatment of valvular heart disease. (medscape.com)
- On July 8, 1997, 24 cases of valvular heart disease in women who had been treated with fenfluramine and phentermine were publicly reported (1). (cdc.gov)
- Fenfluramine was withdrawn from the U.S. market in 1997 after reports of valvular heart disease and pulmonary hypertension. (the-medical-dictionary.com)
- Predictors of Human Milk Feeding and Direct Breastfeeding for Infants with Single Ventricle Congenital Heart Disease: Machine Learning Analysis of the National Pediatric Cardiology Quality Improvement Collaborative Registry. (cdc.gov)
- Lyon said that the "most famous one" is trastuzumab, a monoclonal antibody that is used to treat HER2-positive breast cancer but that also causes left ventricular impairment "in about 15% to 20% of the women taking it and can cause severe heart failure if it is missed. (medscape.com)
- We're doing a lot of surveillance because one of the big advantages of cardio-oncology is we know when someone is about to get treated," Lyon, from the National Heart and Lung Institute, Imperial College London, and Cardio-Oncology Service, Royal Brompton Hospital, London, said. (medscape.com)
- Carcinoid lung cancer is more common in Caucasians than in African-American, Asian-Americans, or Hispanic/Latinos. (parkinsonsdisease-guidebook.com)
- Pathology of the tissue revealed it was carcinoid. (carcinoid.org)
- The author, Maria Gonzalez , is both a breast cancer and carcinoid survivor. (carcinoid.org)
- My experience with carcinoid cancer began in January 1995, although I did not know it at the time. (carcinoid.org)
- Believing that every life story should have a moral, or at least a purpose, here is my encouragement to anyone reading this and trying to learn more about carcinoid cancer. (carcinoid.org)
- that the aim of the guideline was to "personalize the decision-making of a patient with cancer who has cardiovascular disease or is at risk of developing it from their treatment…because it's not one size fits all. (medscape.com)
- He said that one of main drivers is modifiable factors, such as smoking, obesity, and inactivity, which increase the risk for both cancer and cardiovascular disease. (medscape.com)
- Combined with the ageing population, the result is that "not only are many more people being diagnosed with cancer, because they're living longer, but they have all these pre-existing heart risk factors, whether as confirmed disease or just the risk factors associated with that," he said. (medscape.com)
- Crucially, the impact of cancer therapy on cardiovascular risk is dependent on several factors, such as patient age, cancer history, pre-existing cardiovascular risk factors or cardiovascular disease, and pervious cardiotoxic cancer therapy. (medscape.com)
- This retrospective analysis evaluates the use of chromogranin A (CgA), a biomarker widely used in the diagnosis of neuroendocrine tumours (NET), in monitoring CS and disease progression . (bvsalud.org)
- 9. Two-dimensional echocardiography in the diagnosis of carcinoid heart disease. (nih.gov)
- 14. Carcinoid heart disease: diagnosis by two-dimensional echocardiography. (nih.gov)
- In addition, experts in the field of NET disease have continued to develop strategies to improve diagnosis, treatment and management of NET cancers. (nanets.net)
- Early diagnosis can lead to an improved lifestyle, potentially lead to decreased dependence on blood thinners and could preserve heart function. (bswhealth.com)
- Anaemia in Chronic Heart Failure: Is There a Rationale to Treat? (hellenicjcardiol.com)
- rheumatic fever (I00-I02) or rheumatic heart disease (I05-I09) reported as "due to" any disease other than scarlet fever (A38), streptococcal septicemia (A40. (cdc.gov)
- 12. Do indole markers predict carcinoid heart disease? (nih.gov)
- Cardiopulmonary arrest developed during right-heart catheterization, and she died 3 days later. (the-medical-dictionary.com)
- I had a heart attack followed by a couple of small strokes. (carcinoid.org)
- Compression of the heart by accumulated fluid ( PERICARDIAL EFFUSION ) or blood ( HEMOPERICARDIUM ) in the PERICARDIUM surrounding the heart. (nih.gov)
- Allied to that, there's been an improvement in treating cardiovascular diseases in people in their 40s, 50s, and 60s, so they're surviving their heart failure, myocardial infarction, atrial fibrillation to develop cancers in later life. (medscape.com)
- Heart Failure" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. (harvard.edu)
- This graph shows the total number of publications written about "Heart Failure" by people in Harvard Catalyst Profiles by year, and whether "Heart Failure" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Heart Failure" by people in Profiles. (harvard.edu)
- Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure. (harvard.edu)
- As this is a rare disease, clinicians often do not know how to implement the appropriate care plan and until the last ten years, there was great variability in terms of treatment. (nanets.net)