AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Carcinogenicity TestsCarcinogensNeoplasms, ExperimentalCarcinogens, EnvironmentalMutagenicity TestsRats, Inbred F344MutagensToxicity Tests, ChronicToxicologySalmonella typhimuriumInternational CooperationProgram EvaluationVaginal Creams, Foams, and JelliesMetronidazoleAdministration, IntravaginalGelsSpermatocidal AgentsNonoxynolVaginaMesocricetusCell Transformation, NeoplasticCricetinaeBALB 3T3 CellsEmbryo, MammalianTabletsCheekMifepristoneAdministration, OralTablets, Enteric-CoatedWaterPregnancyMonte Carlo MethodClinical Laboratory Information SystemsAlgorithmsWorkflowComputer SimulationMarketingAnimal Testing AlternativesToxicity TestsEconomic CompetitionResearchManufactured MaterialsFacility Regulation and ControlUnited States Food and Drug AdministrationCosmeticsInvestigational New Drug ApplicationDrug IndustryQuality ControlBiosensing TechniquesDisposable EquipmentMitomycinConductometryMaackia
Carcinogenicity Tests: Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Carcinogens, Environmental: Carcinogenic substances that are found in the environment.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Rats, Inbred F344Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Toxicity Tests, Chronic: Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Program Evaluation: Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.Vaginal Creams, Foams, and Jellies: Medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Administration, Intravaginal: The insertion of drugs into the vagina to treat local infections, neoplasms, or to induce labor. The dosage forms may include medicated pessaries, irrigation fluids, and suppositories.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Spermatocidal Agents: Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.Nonoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.Vagina: The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed)Mesocricetus: A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.BALB 3T3 Cells: Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Cheek: The part of the face that is below the eye and to the side of the nose and mouth.Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Monte Carlo Method: In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)Clinical Laboratory Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Workflow: Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Economic Competition: The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Manufactured Materials: Substances and materials manufactured for use in various technologies and industries and for domestic use.Facility Regulation and Control: Formal voluntary or governmental procedures and standards required of hospitals and health or other facilities to improve operating efficiency, and for the protection of the consumer.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Investigational New Drug Application: An application that must be submitted to a regulatory agency (the FDA in the United States) before a drug can be studied in humans. This application includes results of previous experiments; how, where, and by whom the new studies will be conducted; the chemical structure of the compound; how it is thought to work in the body; any toxic effects found in animal studies; and how the compound is manufactured. (From the "New Medicines in Development" Series produced by the Pharmaceutical Manufacturers Association and published irregularly.)Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Disposable Equipment: Apparatus, devices, or supplies intended for one-time or temporary use.Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.Conductometry: Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)Maackia: A plant genus of the family FABACEAE. It contains a hemagglutinin.

Evaluation of the chronic toxicity and oncogenicity of N,N-diethyl-m-toluamide (DEET). (1/865)

Chronic toxicity and/or oncogenicity studies were conducted in rats, mice, and dogs with the insect repellent DEET. DEET was mixed in the diet and administered to CD rats for two years at concentrations that corresponded to dosage levels of 10, 30 or 100 mg/kg/day for males and 30, 100, or 400 mg/kg/day for females; to CD-1 mice for 18 months at dosage levels of 250, 500, or 1000 mg/kg/day; and to dogs for one year, via gelatin capsules, at dosage levels of 30, 100, or 400 mg/kg/day. In the rodent studies, each group consisted of 60 animals of each sex, and two concurrent independent control groups, each containing 60 animals/sex were included in each study. Each group in the dog study consisted of four male and four female dogs and one control group was included in the study. Treatment-related effects were observed at the highest dose level in all three studies. For rats, the effects included decreases in body weight and food consumption and an increase in serum cholesterol in females only. In mice, the effects observed were decreases in body weight and food consumption in both sexes. The effects observed in dogs included increased incidences of emesis and ptyalism, and levels of transient reduction in hemoglobin and hematocrit, increased alkaline phosphatase (males only), decreased cholesterol, and increased potassium. One male dog in the high-dose group also exhibited ataxia, tremors, abnormal head movements, and/or convulsions on several occasions during the study. The highest no-observed-effect levels (NO-ELs) for rats, mice and dogs were determined to be 100, 500, and 100 mg/kg/day, respectively. No specific target organ toxicity or oncogenicity was observed in any of the studies.  (+info)

Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. (2/865)

Intestinal carcinogenesis involves the successive accumulation of multiple genetic defects until cellular transformation to an invasive phenotype occurs. This process is modulated by many epigenetic factors. Unconjugated bile acids are tumor promoters whose presence in intestinal tissues is regulated by dietary factors. We studied the role of the unconjugated bile acid, chenodeoxycholate, in an animal model of familial adenomatous polyposis. Mice susceptible to intestinal tumors as a result of a germline mutation in Apc (Min/+ mice) were given a 10 week dietary treatment with 0.5% chenodeoxycholate. Following this, the mice were examined to determine tumor number, enterocyte proliferation, apoptosis and beta-catenin expression. Intestinal tissue prostaglandin E2 (PGE2) levels were also assessed. Administration of chenodeoxycholate in the diet increased duodenal tumor number in Min/+ mice. Promotion of duodenal tumor formation was accompanied by increased beta-catenin expression in duodenal cells, as well as increased PGE2 in duodenal tissue. These data suggest that unconjugated bile acids contribute to periampullary tumor formation in the setting of an Apc mutation.  (+info)

Malignant transformation of p53-deficient astrocytes is modulated by environmental cues in vitro. (3/865)

The early incidence of p53 mutation in astrocytomas suggests that it plays an important role in astrocyte transformation. Astrocytes isolated from homozygous p53 knockout mice grow rapidly, lack contact inhibition, and are immortal. Here we tested whether the loss of p53 is sufficient for progression to tumorigenicity of astrocytes. We grew primary astrocytes under three conditions for over 120 population doublings and assessed their antigenic phenotype, chromosome number, and expression of glioma-associated genes as well as their ability to form colonies in soft agarose and tumors s.c. and intracranially in nude mice. Under two conditions (10% FCS and 0.5% FCS plus 20 ng/ml EGF), cells acquired the ability to form colonies in soft agarose and tumors in nude mice, and this was accompanied by the expression of genes, including epidermal growth factor receptor, platelet-derived growth factor receptor alpha and beta, protein kinase Cdelta, and vascular endothelial growth factor, which are known to be aberrantly regulated in human astrocytomas. Under the third condition (0.5% FCS plus 10 ng/ml basic fibroblast growth factor), astrocytes gained the ability to form colonies in soft agarose and had abnormal chromosome numbers similar to cells in the first two conditions but did not form tumors in nude mice or overexpress glioma-associated genes. These data provide experimental evidence for the idea that the malignant progression initiated by the loss of p53 may be subject to modulation by extracellular environmental influences.  (+info)

Expression of AML1-d, a short human AML1 isoform, in embryonic stem cells suppresses in vivo tumor growth and differentiation. (4/865)

The human AML1 gene encodes a heterodimeric transcription factor which plays an important role in mammalian hematopoiesis. Several alternatively spliced AML1 mRNA species were identified, some of which encode short protein products that lack the transactivation domain. When transfected into cells these short isoforms dominantly suppress transactivation mediated by the full length AML1 protein. However, their biological function remains obscure. To investigate the role of these short species in cell proliferation and differentiation we generated embryonic stem (ES) cells overexpressing one of the short isoforms, AML1-d, as well as cells expressing the full length isoforms AML1-b and AML2. The in vitro growth rate and differentiation of the transfected ES cells were unchanged. However, overexpression of AML1-d significantly affected the ES cells' ability to form teratocarcinomas in vivo in syngeneic mice, while a similar overexpression of AML1-b and AML2 had no effect on tumor formation. Histological analysis revealed that the AML1-d derived tumors were poorly differentiated and contained numerous apoptotic cells. These data highlight the pleiotropic effects of AML1 gene products and demonstrate for the first time an in vivo growth regulation function for the short isoform AML1-d.  (+info)

Marriage of a medium-term liver model to surrogate markers--a practical approach for risk and benefit assessment. (5/865)

The need for a reliable medium-term alternative to traditional long-term rodent test protocols for carcinogen risk assessment is pressing given the immense variety of compounds being developed for introduction into the human environment. The established lack of a complete correlation between mutagenicity and carcinogenicity means that recourse must be made to an in vivo model. Optimally, this model should be able to detect not only complete carcinogenic or promoting potential but also any ability to inhibit neoplasia. In order to be effective, it must take into account the available detailed knowledge on mechanisms of action of carcinogens and modulating agents. The Ito model, for which a uniquely comprehensive set of background data has already been accumulated, has a solid scientific basis; this model utilizes quantitative data for glutathione S transferase-positive foci as the preneoplasia-based surrogate end point (PSE). A very practical candidate for routine application, its predictive power, its flexibility, and its capacity to incorporate a range of mechanism-based surrogate end points (MSEs) provide a powerful tool for attainment of the twin goals of detecting carcinogenic agents and identifying promising chemopreventors.  (+info)

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. (6/865)

Cell cycle regulatory proteins are important candidates for therapeutic tumour suppressors. Adenovirus vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter. These vectors directed the efficient expression of each of the cyclin kinase inhibitors and induced growth arrest, inhibited DNA synthesis, and prevented phosphorylation of the retinoblastoma protein (pRb) in cell lines expressing functional pRb. In pRb-deficient cells, expression of the cyclin kinase inhibitors was not effective in inhibiting DNA replication or growth arrest. Interestingly, three of the cyclin kinase inhibitors, p16, p18 and p27 were found to induce apoptotic death in transduced HeLa and A549 cells. When the vectors were tested for their ability to inhibit tumorigenicity in a polyomavirus middle T antigen model of murine breast carcinoma, expression of the cyclin kinase inhibitors resulted in a delay in tumour formation that varied from several weeks for the p19 expressing vector to greater than 25 weeks for the p27 expressing vector. When tumours were injected directly with the adenovirus vectors expressing the cyclin kinase inhibitors, only treatment with the vector expressing p16 resulted in a delay in tumour growth.  (+info)

Tumorigenic conversion resulting from inhibition of apoptosis in a nontumorigenic HeLa-derived hybrid cell line. (7/865)

Although tumorigenicity in nude mice is one of the most important transformed phenotypes, its mechanism has been little analyzed. To understand the molecular basis of tumorigenicity, we characterized nontumorigenic CGL1 and tumorigenic CGL4 cell lines, both of which were originated from a common ancestral HeLa-human diploid fibroblast hybrid cell clone and retained a malignant state except tumorigenicity. When injected into nude mice, nontumorigenic CGL1 cells underwent apoptosis, but tumorigenic CGL4 cells did not. In vitro, CGL1 was also less resistant to various apoptotic stimuli than CGL4. These results suggested that inhibition of apoptosis may lead to tumorigenicity. To examine this hypothesis, we introduced antiapoptotic genes into the CGL1 cell line and injected the resulting clones into nude mice. The results showed that the ectopic expression of Bcl-2 or E1B19k, but not of crmA, converted CGL1 cells to tumorigenicity, suggesting strongly that this phenotype may be conferred by evasion of apoptosis.  (+info)

Increased oncogenicity of subclones of SV40 large T-induced neuroectodermal tumor cell lines after loss of large T expression and concomitant mutation in p53. (8/865)

A model for medulloblastoma-like primitive neuroectodermal tumors was established in rat using retrovirally transduced SV40 large T antigen (LT) as an inducing agent (O. D. Wiestler et al., Brain Pathol., 2: 47-59, 1992). A cell line isolated from such a tumor and clonal derivatives thereof were biologically and molecularly characterized. In the parental tumor cell line, TZ870, which had been selected for G418 resistance, virtually all cells expressed LT and wild-type p53, which were complexed to each other. When plated in soft agar, these cells grew relatively slowly and formed disperse colonies. However, when grown without selection pressure, these cells reproducibly gave rise to LT-negative and G418-sensitive derivatives, LT-0 cells. Surprisingly, these latter cells exhibited a higher degree of malignancy both in vitro, growing readily to large colonies in soft agar, and in vivo, where they gave rise to a rapidly growing malignant tumor. Clonal selection from TZ870 cells revealed two types of clones: in one type, LT expression was stably maintained, even without selection pressure, whereas the other type lost the LT coding sequences. All LT-negative clones exhibited the same phenotype as the LT-0 cells. Reexpression of LT had no effect. However, LT no longer formed complexes with p53, and p53 was metabolically stable, suggesting that it had been mutated. Sequence analyses and diagnostic restriction digests of the p53 gene revealed that (a) both the parental LT-transformed cells and their derivatives contained only one complete p53 allele and (b) all LT-positive clones expressed wild-type p53, whereas all LT-negative clones expressed a mutant allele with a common mutation at Cys-174-->Tyr, indicating their clonal origin. We assume that the loss of LT coding sequences is the consequence of the p53 mutation, perhaps by inducing genomic instability, and that both the p53 mutation and additional genetic alterations that accompany the loss of LT coding sequences might contribute to enhanced malignancy.  (+info)

Mutagenicity and Carcinogenicity Assessment Of 1,3-Butadiene by (ISBN: 9781289188702) Paperback Book | BookwireMutagenicity and Carcinogenicity Assessment Of 1,3-Butadiene by (ISBN: 9781289188702) Paperback Book | Bookwire
Mutagenicity and Carcinogenicity Assessment Of 1,3-Butadiene by (ISBN: 978-1-289-18870-2); Published by Creative Media Partners, LLCin Jul 2013. Compare book prices on Bookwire.com to buy books from the lowest price among top online book retailers
About Nemis Journal of Environmental ScienceAbout Nemis Journal of Environmental Science
Aims and scope. Nemis Journal of Environmental Science - NJES is an open access journal that publishes (Monthly) well developed research articles, in English, in all areas of environmental sciences, such as physics, geology, mathematics, analytical and environmental chemistry, environmental biology, ecology, geo-sciences and environmental physics, study on atmospheric, terrestrial and aquatic environments, pollution control and Remediation, conservation of natural resources, environmental health and toxicology, mining, computer science, etc. All articles published in Nemis Journal of Enviromental Scence are peer-reviewed.. Nemis Journal of Environmental Science is published monthly by Nemis Journals.. Open Access. All articles published by Nemis Journal of Environmental Science are made freely and permanently accessible online immediately upon publication, without subscription charges or registration barriers. Authors of articles published in Nemis Journal of Environmental Science are the ...
Carcinogenicity Assessment Using Biosensors: Mitomycin-C As A Case StudyCarcinogenicity Assessment Using Biosensors: Mitomycin-C As A Case Study
This study enabled an empirical assessment of a model carcinogen borne in soil and its potency on human receptors. SOS-lux biosensors had numerous practical advantages over the traditional assays including procedural simplicity, ease of measurement and in vivo analysis without cell disruption. A key advantage of the application of biosensors is their ability to be deployed to genuine samples. This means that while chromatographic analysis requires extraction, purification, clean-up and then analysis, the biosensor can be used in crude and turbid solutions. This could be exclusively for a carcinogenic sensor or for a wider suite of sensors for specific analytes and generic toxicity. Samples could be exposed to a suite of sensors simultaneously allowing a real time response that could prove valuable for the protection of target receptors at a timescale commensurate with intervention. The data presented confirm that the sensors could be fabricated to permit compact analysis and the use of disposable
Abstract for TR-448Abstract for TR-448
Groups of 10 male and 10 female B6C3F1 mice were exposed to 0, 10, 25, 75, 150, or 300 ppm (approximately 42, 105, 315, 630, or 1,260 mg/m3) isobutyl nitrite by inhalation for 6 hours per day, 5 days per week for 13 weeks. There were no chemical-related deaths. Final mean body weights and mean body weight gains of 150 and 300 ppm females were significantly less than those of the controls. Final mean body weights and mean body weight gains of exposed groups of males were similar to those of the controls. There were no chemical-related clinical findings. A very mild chemical-related methemoglobinemia occurred in male and female mice in the 150 and 300 ppm groups. A very mild anemia occurred in the 300 ppm groups. In the lung, increased incidences of mild to moderate hyperplasia of the bronchiolar epithelium occurred in males and females exposed to 300 ppm. Minimal hyperplasia occurred in males exposed to 75 ppm or greater and in females exposed to 150 ppm. Minimal epithelial cell hyperplasia of ...
Test for carcinogenicity Test for carcinogenicity - BusinessTest for carcinogenicity Test for carcinogenicity - Business
Tumours induced by implants are well known in experiments using rats. This phenomenon is called foreign body carcinogenesis or solid state carcinogenesis. Method of test for carcinogenicity :Syrian Hamster Embryo Cell Transformation Assay. ...
National Toxicology Program (1978) Bioassay of 1H-Benzotriazole for Possible Carcinogenicity. National Cancer Institute...National Toxicology Program (1978) Bioassay of 1H-Benzotriazole for Possible Carcinogenicity. National Cancer Institute...
National Toxicology Program (1978) Bioassay of 1H-Benzotriazole for Possible Carcinogenicity. National Cancer Institute Carcinogenesis Technical Report Series, 88, 1-131.
Abstract for TR-356Abstract for TR-356
Dietary concentrations of furosemide used in the 14-day studies for rats and mice ranged up to 46,000 ppm. Two of five male and 3/5 female rats that received 46,000 ppm furosemide died before the end of the studies. Rats that received 15,300 or 46,000 ppm lost weight over the course of the studies. The final mean body weights of rats that received 1,700 or 5,100 ppm were 12% or 23% lower than that of controls for males and 8% or 16% lower for females. Nephrosis was dose related in rats. All five male and 1/5 female mice that received 46,000 ppm furosemide died before the end of the 14-day studies. Male mice that received 15,300 ppm and female mice that received 46,000 ppm lost weight. The final mean body weights of male mice that received 1,700 or 5,100 ppm were 16% or 14% lower than that of controls. The final mean body weight of females that received 15,300 ppm was 13% lower than that of controls. Slight dilatation of the renal cortical tubules and/or nephrosis were dose related in ...
Class Learning: Environmental Science: Systems & Solutions, Sixth EditionClass Learning: Environmental Science: Systems & Solutions, Sixth Edition
The importance of environmental science and environmental studies is indisputable and often the focus of reports in news and media. In order to fully comprehend the issues being discussed-whether it be climate change, air and water pollution, pesticides, nuclear power, or renewable and nonrenewable energy-it is imperative to understand the basic principles necessary to address these multi-faceted and complex environmental concerns. Combining strong scientific grounding with a focus on contemporary case studies, calculations, and references, Environmental Science: Systems and Solutions teaches and engages. It appeals to all students as it covers the basics of environmental science in early chapters and provides the breadth and depth of topics to challenge the more experienced reader. Featuring updated data and statistics with additional tables throughout, the Sixth Edition lays the groundwork for a fair and apolitical foundational understanding of environmental science ...
25-1053.00 - Environmental Science Teachers, Postsecondary25-1053.00 - Environmental Science Teachers, Postsecondary
Teach courses in environmental science. Includes both teachers primarily engaged in teaching and those who do a combination of teaching and research.. Sample of reported job titles: Assistant Professor, Associate Professor, Associate Professor of Environmental Science, Environmental Sciences Professor, Environmental Studies Professor, Faculty Member, Instructor, Lecturer, Professor, Professor of Environmental Science ...
DailyMed - DENAVIR- penciclovir creamDailyMed - DENAVIR- penciclovir cream
In clinical trials, systemic drug exposure following topical administration of penciclovir cream was negligible, as the penciclovir content of all plasma and urine samples was below the limit of assay detection (0.1 mcg/mL and 10 mcg/mL, respectively). However, for the purpose of inter-species dose comparisons presented in the following sections, an assumption of 100% absorption of penciclovir from the topically applied product has been used. Based on the use of the maximal recommended topical dose of penciclovir of 0.05 mg/kg/day and an assumption of 100% absorption, the maximum theoretical plasma AUC0-24 hrs for penciclovir is approximately 0.129 mcg.hr/mL.. Carcinogenesis: Two-year carcinogenicity studies were conducted with famciclovir (the oral prodrug of penciclovir) in rats and mice. An increase in the incidence of mammary adenocarcinoma (a common tumor in female rats of the strain used) was seen in female rats receiving 600 mg/kg/day (approximately 395x the maximum theoretical human ...
Starting or Strengthening a Drug Bulletin - A Practical Manual: Annexe to Chapter 8: Evaluating harm: 8.An-3 Assessing...Starting or Strengthening a Drug Bulletin - A Practical Manual: Annexe to Chapter 8: Evaluating harm: 8.An-3 Assessing...
There are no definite data for carcinogenicity in humans from using tacrolimus (Protopic) ointment, because no large long-term randomised controlled trials have yet been done. But we have a 2-year mouse carcinogenicity study using 0.03% and 0.1% tacrolimus with sham and vehicle-only control, with toxicokinetic data including area under the curve (AUC), and human pharmacokinetic data including AUC.. The lower concentration (0.03%) induced more cancer (all sites) than the vehicle-only control. So it could induce malignancy in long-term clinical use. It seems reasonable to think that small infants may be more affected than adults.. On 26 June 2003, the Advisory Committee to the Japanese Ministry of Health, Labour and Welfare decided to include warnings on a potential cancer risk associated with tacrolimus ointment use, in response to the petition by Kusuri-no-Check and The Informed Prescriber13 insisting that cancer development can be expected considering the animal carcinogenicity tests and ...
About - Environmental Sciences and Pollution Management - LibGuides at ProQuestAbout - Environmental Sciences and Pollution Management - LibGuides at ProQuest
What is Environmental Sciences & Pollution Management?. Environmental Sciences & Pollution Management (ESPM) is a multidisciplinary database which provides comprehensive coverage of the literature relating to environmental sciences dating from 1967 to the present.. Millions of abstracts and citations are included from scientific journals within the relevant literature ensuring researchers have the maximum opportunity to discover articles or papers for their search queries. ProQuest editors assign index terms to describe the documents in journals, books, maps and reports.. Beyond the mainstream peer reviewed journals in this field this resource also provides abstracts of hard-to-get, low circulation grey literature publications (conference proceedings, reports, monographs, books and government publications), sometimes with links back to the full text (typically open access repositories). The database also includes good coverage of international content including non English language ...
Master of Environmental Science (U of T) Info Session Tickets, Sat, 6 Jan 2018 at 1:30 PM | EventbriteMaster of Environmental Science (U of T) Info Session Tickets, Sat, 6 Jan 2018 at 1:30 PM | Eventbrite
Eventbrite - Department of Physical and Environmental Sciences - Graduate Studies presents Master of Environmental Science (U of T) Info Session - Saturday, 6 January 2018 at Environmental Science and Chemistry Building - Univ. of Toronto - Scarborough, Toronto, Ontario. Find event and ticket information.
What is Environmental Science? Environmental Science - [PPTX Powerpoint]What is Environmental Science? Environmental Science - [PPTX Powerpoint]
Slide 1 What is Environmental Science? Environmental Science Slide 2 Environment Environment: two definitions: - The circumstances or conditions that surround an organism…
James Huff, Ph.D. - RetiredJames Huff, Ph.D. - Retired
Returning to the United States in 1980 at the behest of Dr. David Rall, he joined the National Institute of Environmental Health Sciences and the National Toxicology Program. Dr. Huff was the first person hired by Dr. Rall, primarily to help establish the newly created NTP into a world-renowned scientific and public health-oriented program. He was a lead person for the transition of the bioassay program from the National Cancer Institute to the NTP. Dr. Huff introduced and established the NTP levels of evidence of carcinogenicity for the experimental chemical carcinogenesis bioassays for evaluating results, and as still utilized in the bioassay technical reports. While with the NTP he wrote or led the preparation and evaluation of more than 200 carcinogenesis bioassay technical reports. Along with Dr Hans Falk and later joined by Dr Vladimer Vouk, Dr Huff helped establish the Congressionally mandated NTP Report on Carcinogens, now in its 10th edition, into a science-based and globally accepted ...
Transgenic RasH2 mouse carcinogenicity studies now available in Lyon | Charles RiverTransgenic RasH2 mouse carcinogenicity studies now available in Lyon | Charles River
RasH2 mice are more sensitive to developing carcinogen-induced tumors, and can reduce both study timelines and the number of animals required.
Cancer Hazard Signs | SetonCancer Hazard Signs | Seton
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Environmental Sciences Research Laboratory (ESRL) | Environmental SciencesEnvironmental Sciences Research Laboratory (ESRL) | Environmental Sciences
The University of California, Riverside has a long history of working with the Earth, studying and improving agricultural techniques, and delving into many various studies of scientific research involving air, soil, plants, and water. The Environmental Sciences Research Laboratory aims to continue this work, expanding the Departments role in providing opportunities for outside agencies to be able to take advantage of our facilities. Our researchers strive for quality and timeliness in regards to our work, while maintaining high safety standards in accordance with campus policies.
Environmental Sciences Europe - SpringerEnvironmental Sciences Europe - Springer
Articles published between 1989 and 2010 are not published as open access!. Environmental Sciences Europe, formerly known as Umweltwissenschaften und Schadstoff-Forschung (UWSF), is a peer-reviewed open access journal published under the brand SpringerOpen. It is an international journal, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. The journal provides easy access to information on environmental issues at the regional and European level and gives authors the possibility to reach a broader, international readership. ...
Environmental ScienceEnvironmental Science
... is the study of the interaction of the living and non-living components of the environment with special emphasis on the impact of humans on these components. Course: Environmental Science
Dr Patrick Osborne | Geography and Environmental Science | University of SouthamptonDr Patrick Osborne | Geography and Environmental Science | University of Southampton
Dr Patrick Osborne is Reader in Applied Ecology, Director of Programmes for Environmental Science within Geography and Environmental Science at the University of Southampton.
Studying for Environmental Science 101 - Videos & Lessons | Study.comStudying for Environmental Science 101 - Videos & Lessons | Study.com
Review these environmental science flashcards at any time to help you study for exams and solidify your overall environmental science knowledge....
Physicians for Safe Technology | NTP Study on Cell Phones and Cancer 2018Physicians for Safe Technology | NTP Study on Cell Phones and Cancer 2018
National Toxicology Program (NTP) Chronic Carcinogenicity Studies of Cell Phone Radiofrequency Radiation reported results supporting cancer effect of exposure
Danger, Cadmium Cancer Hazard Can Cause Lung And..., 10 x 14, Adhesive Vinyl | StaplesDanger, Cadmium Cancer Hazard Can Cause Lung And..., 10' x 14', Adhesive Vinyl | Staples
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Age and sex dependent changes in liver gene expression during the life cycle of the rat | BMC Genomics | Full TextAge and sex dependent changes in liver gene expression during the life cycle of the rat | BMC Genomics | Full Text
The assessment of gene expression changes at key developmental periods of the life cycle, as well as at the ages most commonly used in pre-clinical drug safety testing, was the focus of this study. Fischer 344 rats are frequently used in the National Toxicology Program and one of the most commonly used inbred strains for preclinical pharmaceutical in-life testing [25, 33]. The two early time points, 2 and 5 weeks, span the time of weaning (3 weeks). The National Toxicology Program (NTP) 2-year bioassays are typically initiated in 6-8 week old rats [34], thus 6 and 8 week age groups were included to provide baseline for future NTP bioassays. The 15-week age group captures expression data after sexual and physical maturity [35]. Furthermore, a 13-week NTP sub-chronic study, initiated in 8 week old animals would be completed at 21 weeks. Reproductive senescence and aging phenotypes begin to be apparent during the second year [35], thus 52, 78, and 104 week age groups were assessed.. Data analysis ...
Environmental Science & Technology》-2007-02Environmental Science & Technology》-2007-02
WU Gui-ping1, 2, AN Wen-hao 3, LU Xiao-hua 1, CHUNG Paul Gene 3 (1.Research Institute of Environmental Science, Huazhong University of Science and Technology, Wuhan 430072; 2.Key Laboratory of Catalysis and Material Science of Hubei Province, School of Chemistry and Material Science, Central South University for Nationalities, Wuhan 430074; 3.Chonbuk National University, Chonbuk 561756) ...
International Symposium on Environmental Science (Beijing)International Symposium on Environmental Science (Beijing)
As a worlds leading chemistry community, the Royal Society of Chemistry is proud to collaborate with the host institutes to organise two International Symposia on Environmental Science. The symposium in Beijing is supported by the Royal Society of Chemistry and the Research Center for Eco-Environmental Sciences (RCEES), Chinese Academy of Sciences, and is hosted by Prof Lianghong Guo from RCEES ...
Program Details : University Catalogs : University of MinnesotaProgram Details : University Catalogs : University of Minnesota
Students are encouraged to fulfill distribution requirements with courses that complement the environmental science major (e.g., ECON 1111 - Microeconomics, ECON 3007 - Environmental and Natural Resource Economics I, and ECON 3008 - Environmental and Natural Resource Economics II). Selection of electives must be done in consultation with an environmental science advisor. By the beginning of their junior year, students should submit a clearly articulated educational plan and a list of selected electives, to be reviewed and approved by the Environmental Science Advisory Group. Courses in the Division of Science and Math, other than those listed below, may be used to fulfill the "Elective Science Courses" with the prior approval of the Environmental Science Advisory Group. Required courses may not be taken S-N unless offered S-N only. Up to 4 credits of coursework with a grade of D or D+ may be used to meet the major requirements. A minimum GPA of 2.00 is required in the major to graduate. The GPA ...
Professor Ian Fairchild - School of Geography, Earth and Environmental Sciences - University of BirminghamProfessor Ian Fairchild - School of Geography, Earth and Environmental Sciences - University of Birmingham
Staff profile for Professor Ian Fairchild, Emeritus Professor in the School of Geography, Earth and Environmental Sciences. Professor Fairchild is a geoscientist with broad interests in the geochemistry of the Earths surface, climate change and Quaternary and Neoproterozoic earth history. He employs this breadth of knowledge in teaching, in public outreach, and professional activities such as examining and research assessment. He is equally at home in the field and the laboratory with a wealth of experience in glacial environments, caves, rock successions and at national and international geochemical research facilities.
Environmental Science PhD Projects, Programs & Scholarships - 193 PhDs ListedEnvironmental Science PhD Projects, Programs & Scholarships - 193 PhDs Listed
Find A PhD. Search Funded PhD Projects, Programs & Scholarships in Environmental Science. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
People | Environmental Science and Design Research Initiative | Kent State UniversityPeople | Environmental Science and Design Research Initiative | Kent State University
People Environmental Science and Design Research Initiative | The ESDRI engages a broad range of scientists, practitioners, and designers, spanning dozens of academic disciplines, fields, and programs. Colleges represented within the ESDRI include the College of Architecture & Environmental Design, the College of the Arts, the College of Arts & Sciences, the College of
Cleaning Up Oil Spills with Oil-Hungry Bacteria Lab | Environmental Science Kits | Environmental Science | Science | Education...Cleaning Up Oil Spills with Oil-Hungry Bacteria Lab | Environmental Science Kits | Environmental Science | Science | Education...
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Frontiers | Editorial: Hybrid Solutions for the Modeling of Complex Environmental Systems | Environmental ScienceFrontiers | Editorial: Hybrid Solutions for the Modeling of Complex Environmental Systems | Environmental Science
Hybrid modelling is the combination of simulatory approaches aimed at the accurate mechanistic modelling of complex dynamic systems (Parrott, 2011; Vincenot et al., 2011). It basically consists in the coupling-to a varying degree ranging from simple comparison to bridging to total fusion-of models based on different existing modelling techniques. This concept may therefore, in some regards, seem trivial and more relevant to engineering than scientific research. Yet seeing this field of study through a purely technical eye produces a limited view of the complexity and open challenges relevant to the design and use of hybrid models. This shall be demonstrated throughout this book, in which we engage in showing the potential of hybrid modelling in environmental science in particular. The latter is a strongly interdisciplinary field devoted to the study of heterogeneous, highly dynamical, often non-linear, complex systems made of numerous different entities-rational or not- interacting in a changing
Environmental Science: Physical Principles and Applications: Rienk van Grondelle and Egbert Boeker | NHBS Book ShopEnvironmental Science: Physical Principles and Applications: Rienk van Grondelle and Egbert Boeker | NHBS Book Shop
Buy Environmental Science: Physical Principles and Applications (9780471495772): NHBS - Rienk van Grondelle and Egbert Boeker, John Wiley & Sons
379081640x - Agent-based Computational Modelling: Applications in Demography, Social, Economic and Environmental Sciences...379081640x - Agent-based Computational Modelling: Applications in Demography, Social, Economic and Environmental Sciences...
Agent-Based Computational Modelling: Applications in Demography, Social, Economic and Environmental Sciences (Contributions to Economics) and a great selection of similar Used, New and Collectible Books available now at AbeBooks.com.
Building the Worlds Largest Cryobank | Earth & Environmental ScienceBuilding the World's Largest Cryobank | Earth & Environmental Science
Maddie Stone, PhD Candidate, Department of Earth & Environmental Science, University of Pennsylvania. Publishes an article in Motherboard.. Motherboard is an online magazine and video channel dedicated to the intersection of technology, science and humans.. http://motherboard.vice.com/read/the-worlds-largest-cryobank-could-help-save-or-revive-our-dying-species. ...
Environmental Science & Technology | Journals | Metabolism of CitiesEnvironmental Science & Technology | Journals | Metabolism of Cities
Environmental Science & Technology (ES&T) is an authoritative source of information for professionals in a wide range of environmental disciplines. The journal combines magazine and research sections and is published both in print and online. ...
Environmental Science Conferences 2020/2021/2022Environmental Science Conferences 2020/2021/2022
Environmental Science Conferences 2020 2021 2022 is for the researchers, scientists, scholars, engineers, academic, scientific and university practitioners to present research activities that might want to attend events, meetings, seminars, congresses, workshops, summit, and symposiums.
Environmental Science: Processes & Impacts 2016 Most Downloaded Articles HomeEnvironmental Science: Processes & Impacts 2016 Most Downloaded Articles Home
This web collection features the top 10 most downloaded articles published in Environmental Science: Processes & Impacts in 2016. Congratulations to all of the authors whose articles have been featured! ...
PPT - AP ENVIRONMENTAL SCIENCE PowerPoint Presentation - ID:6854301PPT - AP ENVIRONMENTAL SCIENCE PowerPoint Presentation - ID:6854301
AP ENVIRONMENTAL SCIENCE. CULTURE, SOCIETY, & ENVIRONMENTAL QUALITY AP EXAM REVIEW QUESTIONS. Answer the following questions on a sheet of paper. Check your answers by the final slide. 1. The release of CFCs was banned under an international treaty written in which of the following...
Bachelor - Environmental Sciences - 3 years - Wageningen UniversityBachelor - Environmental Sciences - 3 years - Wageningen University
Are you interested in programme in Nature or Technology? All information about Environmental Sciences in Wageningen: admission, deadlines and grants
Method 240SL - Bayer Environmental Science - | GreenbookMethod 240SL - Bayer Environmental Science - | Greenbook
View the product label for Method 240SL from Bayer Environmental Science. See active ingredients, product application, restrictions, and more.
Jon Environmental Science Mind Map (Example) - MindMeisterJon Environmental Science Mind Map (Example) - MindMeister
Jon Environmental Science Mind Map, Biomes, Ecosystem, Community, Organisms, Population, Trophic Levels, Biodiversity, Water, New node
Northeastern Junior College environmental scienceNortheastern Junior College environmental science
Find information about Northeastern Junior College environmental science. As the entrance requirements for engineering programs vary, learn about the various specialization options available.
Hexane, commercial grade (52% n-hexane, 16% 3-methylpentane, 16% methylcyclopentane): Carcinogenic Potency DatabaseHexane, commercial grade (52% n-hexane, 16% 3-methylpentane, 16% methylcyclopentane): Carcinogenic Potency Database
Hexane, commercial grade (52% n-hexane, 16% 3-methylpentane, 16% methylcyclopentane) Results in the Carcinogenic Potency Database
Environmental Science | 2017-2018 Catalog | Drexel UniversityEnvironmental Science | 2017-2018 Catalog | Drexel University
The environmental science program at Drexel University is committed to educating undergraduates for technical careers and graduate study in the diverse areas of environmental science vital to understanding, conservation and restoration of clean and healthy natural environments in the 21st century. The affiliation between the Academy of Natural Science and Drexel University offers students unique opportunities to take a leadership role in ecology, environmental science and environmental policy, and to grow the scope, capacity and reputation of the natural sciences at the University. The philosophy of the Biodiversity, Earth, and Environmental Science Department is "Experiential Learning Early and Often.. Environmental science is a multidisciplinary field designed to examine environmental problems and find solutions. This field requires understanding of a number of disciplines, including biology, physics and chemistry. Solving some of our environmental problems also requires knowledge of ...
A data-based assessment of alternative strategies for identification of potential human cancer hazards<...A data-based assessment of alternative strategies for identification of potential human cancer hazards<...
TY - JOUR. T1 - A data-based assessment of alternative strategies for identification of potential human cancer hazards. AU - Boobis, R. Alan. AU - Cohen, M. Samuel. AU - Doerrer, G. Nancy. AU - Galloway, M. Sheila. AU - Haley, J. Patrick. AU - Hard, C. Gordon. AU - Hess, G. Frederick. AU - Macdonald, S. James. AU - Thibault, Stéphane. AU - Wolf, C. Douglas. AU - Wright, Jayne. N1 - Copyright: Copyright 2010 Elsevier B.V., All rights reserved.. PY - 2009. Y1 - 2009. N2 - The two-year cancer bioassay in rodents remains the primary testing strategy for in-life screening of compounds that might pose a potential cancer hazard. Yet experimental evidence shows that cancer is often secondary to a biological precursor effect, the mode of action is sometimes not relevant to humans, and key events leading to cancer in rodents from nongenotoxic agents usually occur well before tumorigenesis and at the same or lower doses than those producing tumors. The International Life Sciences Institute (ILSI) Health ...
19.13 Environmental Science Program19.13 Environmental Science Program
The Environmental Science Program is an interdisciplinary graduate program involving the science-based departments of Memorial University of Newfoundland and along with the Environmental Engineering Program makes up Memorials Environmental Studies Graduate Program. There are two Environmental Science Graduate degree streams, the Master of Science (M.Sc., Environmental Science) and the Master of Environmental Science (M.Env. Sci.). The program is available on a full-time or part-time basis. Admission is open to students with Science or Engineering backgrounds. ...
ASLO : Forums : Research Associate, Environmental Sciences (closes 8/11/2018)ASLO : Forums : Research Associate, Environmental Sciences (closes 8/11/2018)
Research Associate, Environmental Sciences. The Department of Environmental Sciences at the University of Virginia (UVA) seeks a Research Associate to contribute to computational research on ocean tritium and helium isotope distributions in the framework of the Community Earth System Model. The research associate will work directly with Scott Doney in the Department of Environmental Sciences.. The candidate must have experience with ocean circulation modeling, data analysis and visualization. Prior experience with ocean transient tracers, marine biogeochemistry, and the Community Earth System Model or similar global model is preferred. Strong skills in verbal and written communication of scientific results, ability to work both independently and collaboratively as a member of interdisciplinary teams, and ability to organize, prioritize, and coordinate multiple tasks are required skills.. Appointment is for one year with possibility of a renewal for one additional year, contingent upon ...
F8D4 - Environmental Sciences (Agricultural and Environmental Science) - Undergraduate - Newcastle UniversityF8D4 - Environmental Sciences (Agricultural and Environmental Science) - Undergraduate - Newcastle University
We offer several Environmental Science degrees including a three-year BSc degree and a suite of four-year MEnvSci degrees.. We understand that you might not be sure which area of environmental science you want to specialise in, or whether you want to study to BSc or MEnvSci level.. All our students, regardless of which degree they are registered on, study the same modules for the first three years. This means you can transfer between degree programmes up until the end of Stage 2 if you want to.. Transfer from our BSc to an MEnvSci degree, and progress to Stage 4 of an MEnvSci degree, is subject to you meeting the appropriate academic standard.. ...
CHEMICALS: National Toxicology Program deems formaldehyde carcinogenic -- Friday, June 10, 2011 -- www.eenews.net E&E News --...CHEMICALS: National Toxicology Program deems formaldehyde carcinogenic -- Friday, June 10, 2011 -- www.eenews.net E&E News --...
The National Toxicology Program (NTP) declared today that formaldehyde -- a common ingredient in home building products -- causes cancer in humans. NTP, which is administered by the National Institute…
squamous cell papilloma - Humpath.com - Human pathologysquamous cell papilloma - Humpath.com - Human pathology
malpighian papilloma ; squamous papilloma WP Images tonsilar squamous cell papilloma https://twitter.com/AlesitaRosell/status/84380529783569
Propiolactone (IARC Summary & Evaluation, Volume 71, 1999)Propiolactone (IARC Summary & Evaluation, Volume 71, 1999)
5.1 Exposure data. The main use of b-propiolactone has been as an intermediate in the production of acrylic acid and its esters. It has also been used for the sterilization of vaccines and blood products.. 5.2 Human carcinogenicity data. No data were available to the Working Group.. 5.3 Animal carcinogenicity data. b-Propiolactone was tested for carcinogenicity in mice by skin application and subcutaneous or intraperitoneal injection and in rats by inhalation exposure and subcutaneous injection, producing local tumours. The results obtained in studies in hamsters and guinea-pigs were equivocal.. 5.4 Other relevant data. b-Propiolactone is a direct-acting alkylating agent. It forms DNA adducts. It is mutagenic in a wide variety of in-vitro and in-vivo systems, both in somatic and germ cells.. 5.5 Evaluation. No epidemiological data relevant to the carcinogenicity of b-propiolactone were available.. There is sufficient evidence in experimental animals for the carcinogenicity of ...
Technical Reports on Processed & Packaged Goods Equities -- General Mills, Ingredion, Kellogg, andTechnical Reports on Processed & Packaged Goods Equities -- General Mills, Ingredion, Kellogg, and
NEW YORK, September 12, 2017 /PRNewswire/ -- Technical Reports on Processed & Packaged Goods Equities -- General Mills, Ingredion, Kellogg, and McCormick.
Zalcitabine (IARC Summary & Evaluation, Volume 76, 2000)Zalcitabine (IARC Summary & Evaluation, Volume 76, 2000)
5.1 Exposure data. Zalcitabine is a nucleoside analogue that has been used to treat HIV infections in adults and children. The drug entered clinical use around 1990, but it is no longer in common use since several clinical studies showed it to be less active than other nucleoside analogues.. 5.2 Human carcinogenicity data. The only data available were from two trials designed to assess the efficacy of zalcitabine in improving the degree of immunocompetence and survival of patients with HIV infection and one phase I trial of zalcitabine alternated with zidovudine. No conclusion could be drawn concerning carcinogenicity.. 5.3 Animal carcinogenicity data. Zalcitabine was tested for carcinogenicity in four studies in mice by gavage. Treatment resulted in induction of thymic lymphomas in all studies.. 5.4 Other relevant data. The human pharmacokinetics of orally administered zalcitabine appears to be linear over a broad dose range. Zalcitabine is about 80% bioavailable and is rapidly absorbed, ...
Cancer Chemotherapy Use During Pregnancy - The ASCO PostCancer Chemotherapy Use During Pregnancy - The ASCO Post
INSIDE THE BLACK BOX is an occasional column providing insight into the FDA and its policies and procedures. In this installment, National Toxicology Program scientists Kembra L. Howdeshell, PhD, and Michael D. Shelby, PhD, discuss a recently completed monograph that reviews the published data on pregnancy outcomes in women who received chemotherapy for cancer during pregnancy. Dr. Howdeshell and Dr. Shelby (retired) are Health Scientists with the Office of Health Assessment and Translation, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health. In May 2013, the National Toxicology Program completed a Monograph on Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use During Pregnancy.1 The Monograph is intended as a resource for clinicians and their pregnant patients and provides a comprehensive literature review of the human data, including all available data on follow-up evaluations in gestationally ...
Toxicity predictions with lazar and predictive toxicology bookToxicity predictions with lazar and predictive toxicology book
Apologies if you receive multiple copies of this message! ======================================================== The lazar system for free online predictions of toxic activities is now available at http://www.predictive-toxicology.org/lazar/! You can use a webinterface to draw chemical structures and to obtain predictions for rodent (rat and mice) carcinogenicity and Salmonella mutagenicity. Further toxicity endpoints will be available in the future. At the same time I want to take the opportunity to announce the new book Predictive Toxicology that I have edited. It covers state-of-the art techniques, databases, application areas and the most important predictive toxicology programs. Predictive Toxicology has been published by Marcel Dekker/CRC Press. If you are interested in confidential predictions, batch predictions or the development of modules for new endpoints, please contact helma at in-silico.de. If you want to receive also in the future information about new lazar developments, ...
Academics | Geological and Environmental Sciences | Western Michigan UniversityAcademics | Geological and Environmental Sciences | Western Michigan University
Western Michigan University has a proud legacy of specialized educators, dating back from its heritage as a normal school from 1903 to 1930. In its 50+ year history, the Department of Geological and Environmental Sciences has continued to build on this legacy. Today, 20 percent of our faculty focus on teaching and performing research related to improving educational methods in the geological and environmental sciences. Furthermore, teaching faculty work very closely with research faculty to develop new courses and continuously improve existing ones to match the highest requirements for nationally and internationally reputed geological and environmental programs. Undergraduate students receive an education that is 60 percent focused on classroom instruction and 40 percent on hands-on applications with a diverse set of laboratory measurements and field courses. Graduate students receive an education that is 20 to 40 percent focused on classroom/laboratory education with a 60 to 80 percent focus on ...
American Journal of Environmental Sciences · Science PublicationsAmerican Journal of Environmental Sciences · Science Publications
American Journal of Environmental Sciences is an international peer reviewed journal, presents original research articles, reviews, and letters in all areas of environmental studies and environmental sciences.. ...
American Journal of Environmental Sciences · Science PublicationsAmerican Journal of Environmental Sciences · Science Publications
American Journal of Environmental Sciences is an international peer reviewed journal, presents original research articles, reviews, and letters in all areas of environmental studies and environmental sciences.. ...
7th Annual Kent State Environmental Science & Design Research Symposium | Kent State University7th Annual Kent State Environmental Science & Design Research Symposium | Kent State University
7th Annual Kent State Environmental Science & Design Research Symposium Environmental Science and Design Research Initiative | Poster session materials online! Check out all of this years posters and abstracts on the Universitys Institutional Repository.
ECU Undergraduate Catalog 2000-2001 - Section 9 - Courses - GERMECU Undergraduate Catalog 2000-2001 - Section 9 - Courses - GERM
5501. Independent Study: Visual Communications (3). HESC: HUMAN ENVIRONMENTAL SCIENCES 2126. Consumer Affairs (3) The consumer in the market place; bases for decision making, consumption patterns, and trends; consumer information and protection.. 3990, 3991, 3992. Field Experience in Human Environmental Sciences (1,1,1) (F) (S) (SS) May not be substituted for other required internships. P: HESC major or minor; minimum cumulative 2.0 GPA; minimum 2.5 GPA in HESC; 6 s.h. in applicable human environmental sciences area; consent of dean. Supervised professional work experience in the area of the students major or minor. 3999. Issues in Human Environmental Sciences (3) (F) (S) (SS) P: Junior standing and HESC major. Introduces current issues in human environmental sciences; demonstrates methodologies and approaches to resolving these issues in an integrative fashion.. 4500, 4501, 4502. Independent Study (3,3,3) (F) (S) (SS) Problems in one or more of the following areas of human environmental ...
Mutation Research - Genetic Toxicology and Environmental MutagenesisMutation Research - Genetic Toxicology and Environmental Mutagenesis
... (MRGTEM) publishes papers advancing knowledge in the field of genetic toxicology...
Paraffin waxes and Hydrocarbon waxes,... - Registration Dossier - ECHAParaffin waxes and Hydrocarbon waxes,... - Registration Dossier - ECHA
Oral and dermal carcinogenicity studies have been conducted on waxes, and were judged to be negative, i. e., the waxes were not considered to be carcinogenic. Based on a report that the application dose in the dermal carcinogenesis studies was approximately 7.5 mg, applied three times per week, and assuming an average body weight for the mice of 25 g, the average daily dose in the dermal studies was approximately 128 mg/kg/day. In a key carcinogenicity study (Klimisch score = 2), five petroleum waxes (3 of the waxes were microcrystalline and the other two were unidentified) were given to male and female Sprague-Dawley rats at a dietary concentration of 10% for 2 years (Shubik et al., 1962). Survival rates and growth rates were unaffected by oral exposure to any of the waxes tested. A number of tumours were found in all groups at necropsy. The most common tumours were those of the mammary regions (fibrocarcinomas, adenocarcinomas, fibromas, and sarcomas), of the adrenal glands (cortical adenomas ...
Diisotridecyl adipate - Registration Dossier - ECHADiisotridecyl adipate - Registration Dossier - ECHA
In a 103-week carcinogenicity study, the read-across substance DEHA was administered to F344 rats and B6C3F1 mice in the diet at levels of 12000 or 25000 ppm, equivalent to a daily intake of 600 or 1250 mg/kg of body weight in rats and 1715 or 3570 mg/kg of body weight in mice (conversion based on data from the WHO report (2004)). No test substance related tumors were found in the rat (no increased tumour incidences). In the (female) mice an increased number of hepatocellular carcinomas was found at both doses. Hepatocellular adenomas and carcinomas occured combined in high-dose mice of both sexes and in low-dose female mice at incidences that were dose-related and significantly higher than those in control mice. The association of liver tumours in male mice with the administration of DEHA was not considered to be conclusive because the increased number of liver tumours in males reflected only an increase in adenomas in the high-dose group and because the time to observation of tumours was not ...
Aspartame - Cancer Causing - Functional Performance Systems (FPS)Aspartame - Cancer Causing - Functional Performance Systems (FPS)
An independent study done by European Ramazzini Foundation of Oncology and Environmental Sciences in Italy shows the intake of aspartame at far less than daily allowable levels is multi-carcinogenic (lymphomas and leukemias) in laboratory rats. Aspartame is marketed as Nutrasweet, Equal, and Aminosweet and commonly found in "diet" products such as diet sodas.. First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats. "Our study shows that APM is a multipotential carcinogenic compound whose carcinogenic effects are evident even at a daily dose of 20 mg/kg bw, much less than the current ADI for humans in Europe (40 mg/kg bw) and in the United States (50 mg/kg bw).. The results of carcinogenicity bioassays in rodents are consistent predictors of human cancer risks (Huff 1999; Rall 1995; Tomatis et al. 1989). The results of our study therefore call for an urgent reexamination of the present guidelines on the use and ...
P1688R0: Towards a C++ Ecosystem Technical ReportP1688R0: Towards a C++ Ecosystem Technical Report
At the ISO C++ Kona 2019 meeting, the ISO C++ Committees Tooling Study Group, SG15, met to discuss concerns raised by various stakeholders about how modules would impact and interact with the broader C++ ecosystem (build systems, tools, other languages, etc). During that discussion, SG15 reached a consensus that the best way to prepare the C++ community for modules and ensure a smooth transition to modules over the next decade would be to prepare a C++ Ecosystem Technical Report on modules.. Since that meeting, the Tooling Study Group has held a series of telecons to plan, discuss, and brainstorm ideas for the proposed Technical Report. One of the outcomes of these telecons is an outline and high-level design for the proposed Technical Report, as described below.. ...
angiosarcoma of spleen disorder 2005:2010[pubdate] *count=100 - BioMedLib™ search engineangiosarcoma of spleen disorder 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Adipose Tissue, Brown / drug effects. Adipose Tissue, Brown / metabolism. Adipose Tissue, Brown / pathology. Administration, Oral. Animals. Carcinogenicity Tests / methods. Dose-Response Relationship, Drug. Female. Gene Expression Profiling. Hemangiosarcoma / genetics. Hemangiosarcoma / pathology. Hepatocytes / drug effects. Hepatocytes / metabolism. Hepatocytes / pathology. Humans. Hypoglycemic Agents / administration & dosage. Hypoglycemic Agents / toxicity. Male. Mice. Mice, Transgenic. Oligonucleotide Array Sequence Analysis / methods. Reverse Transcriptase Polymerase Chain Reaction. Sex Factors. Time Factors. Vacuoles / drug ...
Surface Chemistry in Biomedical and Environmental ScienceSurface Chemistry in Biomedical and Environmental Science
www.MOLUNA.de Surface Chemistry in Biomedical and Environmental Science [4093859] - Proceedings of the NATO Advanced Research Workshop on Pure and Applied Surface Chemistry and Nanomaterials for Human Life and Environmental Protection, Kyiv, Ukraine, 14-17 September 2005In September 2005 a NATO Advanced Research Workshop convened in Kiev to discuss the current state of the art in surface chemistry and nanomaterials research,
Bacteria go on a DIET - Environmental Science: Processes & Impacts blogBacteria go on a DIET - Environmental Science: Processes & Impacts blog
Probably not the type of diet you are thinking of. It has something to do with food, though. I am talking about the transfer mechanisms some bacteria use to share metabolites between them, and also with bacteria of different species. In this review published in Environmental Science: Processes & Impacts, two researchers from North Carolina analyse the latest discoveries in this field, specifically in mechanisms known as DIET: "direct interspecies electron transfer".. Scientists discovered DIET not a decade ago. Before that, only conventional diffusion models were known: an organism generated an excess of certain metabolite, released it to the surrounding media and was consumed by a second organism. This is called "mediated interspecies electron transfer" (MIET).. DIET, however, is more efficient. Instead of releasing the metabolites around, bacteria use structures that allow them to transfer chemical substances directly to other cells. These structures, usually filamentous pili full of ...
Self-diffusion barriers: possible descriptors for dendrite growth in batteries? - Energy & Environmental Science (RSC...Self-diffusion barriers: possible descriptors for dendrite growth in batteries? - Energy & Environmental Science (RSC...
Dendrite formation is one of the most pressing issues in current battery research. Lithium based batteries are prone to forming short-circuit causing dendrites, while magnesium based batteries are not. Recently it was proposed that the tendency towards dendrite growth is related to the height of the self-dif 2018 Energy and Environmental Science HOT Articles
Asset Based Approaches for Community Engagement - Oxford Research Encyclopedia of Environmental ScienceAsset Based Approaches for Community Engagement - Oxford Research Encyclopedia of Environmental Science
This is an advance summary of a forthcoming article in the Oxford Research Encyclopedia of Environmental Science. Please check back later for the full article.The burden of ill health has shifted, globally, from communicable to non-communicable disease, with poor health clustering in areas of economic deprivation. However, for the most part, public health programs remain focused on changing behaviors associated with poor health (such as smoking or physical inactivity) rather than the contexts that give rise to, and influence, the wide range of behaviors associated with poor health. This way of understanding and responding to population ill health views poor health behavior as a defining
Course: F&ES 510Ea Introduction to Statistics and Data Analysis in the Environmental Sciences | Yale School of Forestry &...Course: F&ES 510Ea Introduction to Statistics and Data Analysis in the Environmental Sciences | Yale School of Forestry &...
An introduction to statistics and data analysis with emphasis on practical applications in the environmental sciences. Includes graphical analysis, common probability distributions, hypothesis testing, confidence intervals, and linear regression. The second part of the course introduces the topics of multiple regression and ANOVA that are typically not covered in an introductory class such as AP statistics. There are weekly problem sets using MINITAB, SPSS, or R, as well as a final project. This course is a prerequisite for other statistics courses offered through F&ES, and it presents statistical methods used in many Yale courses in both the natural and social sciences. This course is taught in a flipped classroom approach: students watch videos before class, and classroom time is spent answering questions and working examples on computers. Enrollment limited to thirty ...
Masters in Environmental Science Programs & Degrees in BuffaloMasters in Environmental Science Programs & Degrees in Buffalo
Review Environmental Science Masters Degrees & Graduate Programs in Buffalo on GradSchools.com the top site for accredited colleges.
Masters in Environmental Science Programs & Degrees in PennsylvaniaMasters in Environmental Science Programs & Degrees in Pennsylvania
Review Environmental Science Masters Degrees & Graduate Programs in Pennsylvania on GradSchools.com the top site for accredited colleges.
AP Environmental Science Products Spotlight: PASCOAP Environmental Science Products Spotlight: PASCO
Teach students with standards-based curriculum supported by the measuring capabilities of wireless sensors and PASCOs flexible and intuitive SPARKvue software on your choice of platform. View our complete curriculum solution for Advanced Environmental Science featuring 24 fully editable lab activities for Advanced Environmental & Earth Sciences, your choices of sensor bundles providing the necessary probeware and equipment and interfacing options to fit your needs.. *AP is a registered trademark of the College Board, which was not involved in the production of, and does not endorse, this product.. ...
July 16, 1999 - UC Davis College of Agricultural and Environmental SciencesJuly 16, 1999 - UC Davis College of Agricultural and Environmental Sciences
The National Agricultural Alumni and Development Association presented the College of Agricultural and Environmental Sciences with five design awards at its 24th annual conference in July held at Cornell University. The organization is comprised of alumni and development professionals from land-grant colleges of agriculture across the nation. CA&ES Outlook, the colleges bi-annual alumni publication, was awarded FIRST PLACE for excellence in the "Alumni and Donor Publications, One-to-Three Color Periodical" category. The colleges 90th Anniversary Brochure, developed over a period of two years and published in 1999, received a SECOND PLACE award for excellence in the "Alumni Projects: Event and Promotional Materials, Single Piece" category. The CA&ES 1998 Holiday Card received THIRD PLACE for excellence in the "Development Projects: Stewardship Materials" category. The Exotic Bird Report newsletter of the Psittacine Research Project, developed with James Millam and Chris Craig-Veit of the ...
Nims, Therese - Cross Category / Ecology/Environmental ScienceNims, Therese - Cross Category / Ecology/Environmental Science
COURSE DESCRIPTION:. Ecology/Environmental Science is a course designed to enhance the students awareness of their role as member of their local ecosystem. In this course students will gain and apply knowledge about natural resources, conservation, and current environmental problems such as pollution, ozone depletion, deforestation, acid rain, and human impact on the ecosystem. Recommended Prerequisites: Biology Elective Course-- Intended for grade 12; may be taken concurrently with Physics.. ...
Faculty of Agricultural and Environmental Sciences, including School of Dietetics and Human Nutrition (Undergraduate) | 2014...Faculty of Agricultural and Environmental Sciences, including School of Dietetics and Human Nutrition (Undergraduate) | 2014...
The Faculty of Agricultural and Environmental Sciences is located on McGill Universitys Macdonald campus, in the Montreal suburb of Ste-Anne-de-Bellevue. It is an oasis of green space in the midst of an urban environment, occupying a splendid waterfront setting connected by a free 45-minute shuttle ride to the Downtown campus.. What makes the Macdonald campus approach to learning unique? Its discovering the thrill of scientific investigation through hands-on work. Its gaining the expertise to help feed the planet and protect the environment. Youll benefit from small classes and have the opportunity for study abroad.. Select a category from the menu to find out more.. ...
Umu ChromotestUmu Chromotest
SOS chromotestSOS chromotest
Sudan ISudan I
2,4-DB2,4-DB
PerfumePerfume
GenotoxicityGenotoxicity
Liquid PaperLiquid Paper
MirexMirex
4-Chloro-o-toluidine4-Chloro-o-toluidine
BioassayBioassay
HydroxymethylfurfuralHydroxymethylfurfural
Drug developmentDrug development
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
Mineral woolMineral wool
Reversible inhibition of sperm under guidanceReversible inhibition of sperm under guidance
Medroxyprogesterone acetateMedroxyprogesterone acetate
Intratracheal instillationIntratracheal instillation
Louise M. RyanLouise M. Ryan
HMXHMX
Simvastatin/sitagliptinSimvastatin/sitagliptin
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
FurylfuramideFurylfuramide
Safe Drinking Water ActSafe Drinking Water Act
Animals and tobacco smokeAnimals and tobacco smoke
Nickel(II) sulfateNickel(II) sulfate
Dimethyl tetrachloroterephthalateDimethyl tetrachloroterephthalate
DNA-directed RNA interferenceDNA-directed RNA interference
Umu ResponseUmu Response
PolyurethanePolyurethane
CholangiocarcinomaCholangiocarcinoma
Open accessOpen access
GasolineGasoline
Arsenic trisulfideArsenic trisulfide
Dioxins and dioxin-like compoundsDioxins and dioxin-like compounds
Serotonin-norepinephrine-dopamine reuptake inhibitorSerotonin-norepinephrine-dopamine reuptake inhibitor
CancerCancer
Benzoyl peroxideBenzoyl peroxide
Health effects of tobaccoHealth effects of tobacco
HerbicideHerbicide
ChromiumChromium
GlyphosateGlyphosate
BayerBayer
Laboratory ratLaboratory rat
AnilineAniline
Malachite greenMalachite green
Building insulation materialsBuilding insulation materials
ChlorineChlorine
Effects of cannabisEffects of cannabis
CiclosporinCiclosporin
CiprofloxacinCiprofloxacin
Toxic Substances Control Act of 1976Toxic Substances Control Act of 1976
4-Methylimidazole4-Methylimidazole
AspartameAspartame
FiberglassFiberglass
Diesel exhaustDiesel exhaust
DDTDDT
Silicon dioxideSilicon dioxide
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Carcinogenicity TestsCarcinogensNeoplasms, ExperimentalCarcinogens, EnvironmentalMutagenicity TestsRats, Inbred F344MutagensToxicity Tests, ChronicToxicologySalmonella typhimuriumInternational CooperationProgram EvaluationVaginal Creams, Foams, and JelliesMetronidazoleAdministration, IntravaginalGelsSpermatocidal AgentsNonoxynolVaginaMesocricetusCell Transformation, NeoplasticCricetinaeBALB 3T3 CellsEmbryo, MammalianTabletsCheekMifepristoneAdministration, OralTablets, Enteric-CoatedWaterPregnancyMonte Carlo MethodClinical Laboratory Information SystemsAlgorithmsWorkflowComputer SimulationMarketingAnimal Testing AlternativesToxicity TestsEconomic CompetitionResearchManufactured MaterialsFacility Regulation and ControlUnited States Food and Drug AdministrationCosmeticsInvestigational New Drug ApplicationDrug IndustryQuality ControlBiosensing TechniquesDisposable EquipmentMitomycinConductometryMaackia
NIOSHTIC-2 Publications Search - 20033962 - Workshop report: chronic inhalation toxicity and carcinogenicity testing of...NIOSHTIC-2 Publications Search - 20033962 - Workshop report: chronic inhalation toxicity and carcinogenicity testing of...
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Exact significance levels for multiple binomial testing with application to carcinogenicity screensExact significance levels for multiple binomial testing with application to carcinogenicity screens
Ratio estimates, the delta method, and quantal response tests for increased carcinogenicity | RTIRatio estimates, the delta method, and quantal response tests for increased carcinogenicity | RTI
KAKEN - Research Projects | Study on Rapid Carcinogenicity Test Using Transgenic Mice (KAKENHI-PROJECT-05508005)KAKEN - Research Projects | Study on Rapid Carcinogenicity Test Using Transgenic Mice (KAKENHI-PROJECT-05508005)
BS EN ISO 10993-3:2014 - Biological evaluation of medical devices. Tests for genotoxicity, carcinogenicity and reproductive...BS EN ISO 10993-3:2014 - Biological evaluation of medical devices. Tests for genotoxicity, carcinogenicity and reproductive...
Glycol Ethers 2-Methoxyethanol & 2-Ethoxyethanol (83-112) | NIOSH | CDCGlycol Ethers 2-Methoxyethanol & 2-Ethoxyethanol (83-112) | NIOSH | CDC
Epuris (Isotretinoin Capsules): Uses, Dosage, Side Effects, Interactions, WarningEpuris (Isotretinoin Capsules): Uses, Dosage, Side Effects, Interactions, Warning
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Test for carcinogenicity Test for carcinogenicity - BusinessTest for carcinogenicity Test for carcinogenicity - Business
The EPA National Library Catalog | EPA National Library Network | US EPAThe EPA National Library Catalog | EPA National Library Network | US EPA
Comparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicalsComparison of target organs of carcinogenicity for mutagenic and non-mutagenic chemicals
WHO HQ Library catalog › Results of search for su:{Carcinogenicity tests}WHO HQ Library catalog › Results of search for 'su:{Carcinogenicity tests}'
ELMIRON®-100 MG (PENTOSAN POLYSULFATE SODIUM) CAPSULESELMIRON®-100 MG (PENTOSAN POLYSULFATE SODIUM) CAPSULES
4 Genotoxicity and Carcinogenicity | Health Effects of Beryllium Exposure: A Literature Review | The National Academies Press4 Genotoxicity and Carcinogenicity | Health Effects of Beryllium Exposure: A Literature Review | The National Academies Press
Animal Models in Drug Discovery | Taconic BiosciencesAnimal Models in Drug Discovery | Taconic Biosciences
GyMiso Tablets - NPS MedicineWiseGyMiso Tablets - NPS MedicineWise
Non-Clinical Engineering Tests and Recommended Labeling for Intravascular Stents and Associated Delivery Systems - Guidance for...Non-Clinical Engineering Tests and Recommended Labeling for Intravascular Stents and Associated Delivery Systems - Guidance for...
Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity (Book, 1978) [WorldCat.org]Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity (Book, 1978) [WorldCat.org]
IJMS | Free Full-Text | Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust...IJMS | Free Full-Text | Additive SMILES-Based Carcinogenicity Models: Probabilistic Principles in the Search for Robust...
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The EPA National Library Catalog | EPA National Library Network | US EPAThe EPA National Library Catalog | EPA National Library Network | US EPA
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Toxicology and Carcinogenicity StudiesToxicology and Carcinogenicity Studies
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Carcinogenicity TestsCarcinogensNeoplasms, ExperimentalCarcinogens, EnvironmentalMutagenicity TestsRats, Inbred F344MutagensToxicity Tests, ChronicToxicologySalmonella typhimuriumInternational CooperationProgram EvaluationVaginal Creams, Foams, and JelliesMetronidazoleAdministration, IntravaginalGelsSpermatocidal AgentsNonoxynolVaginaMesocricetusCell Transformation, NeoplasticCricetinaeBALB 3T3 CellsEmbryo, MammalianTabletsCheekMifepristoneAdministration, OralTablets, Enteric-CoatedWaterPregnancyMonte Carlo MethodClinical Laboratory Information SystemsAlgorithmsWorkflowComputer SimulationMarketingAnimal Testing AlternativesToxicity TestsEconomic CompetitionResearchManufactured MaterialsFacility Regulation and ControlUnited States Food and Drug AdministrationCosmeticsInvestigational New Drug ApplicationDrug IndustryQuality ControlBiosensing TechniquesDisposable EquipmentMitomycinConductometryMaackia
CarcinogensEvidence of carcinogenicityMutagenicityCompoundsToxicologyVitro testsMiceRodentChemicalsCancerAssaysIrritationTumorMutagenicAssayTarget organsVivoOrgansExposureEvaluation2016Chronic1978MechanismsBacterialSpeciesSystemic toxicityGenotoxicity testsDataStudiesDose-responseHazardsLaboratoryEvaluateReproductiveExperimentalAnimalAmesCarcinogenesisOECD Test GuidelinesAssessmentConcernStudyDamageHumanMammalianGuidanceLungApproachesPotentialAnimals
Carcinogens6
Evidence of carcinogenicity3
Mutagenicity5
Compounds13
Toxicology7
Vitro tests1
  • It was decided that this would be best achieved by the organization of ECVAM workshops on specific topics, at which small groups of invited experts would review the current status of various types of in vitro tests and their potential uses and make recommendations about the best ways forward (1). (jhsph.edu)
Mice1
Rodent2
Chemicals13
Cancer5
  • Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity/National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. (worldcat.org)
  • Tests for cancer and other long-term effects of exposure. (humanesociety.org)
  • The Department of Health and Human Services, the International Agency for Research on Cancer, and the Environmental Protection Agency (EPA) have not classified hexamethylene diisocyanate as to its human carcinogenicity. (cdc.gov)
  • A description of methods used in the CPDB to standardize the diverse literature of animal cancer tests is presented for: 1) Criteria for inclusion of experiments 2) Standardization of average daily dose levels and 3) TD 50 estimation for a standard lifespan . (nih.gov)
  • These results are the source information for the Cancer Test Summary table above. (nih.gov)
Assays1
  • The general approach taken by the document is primarily to provide guidance on how test results might be interpreted based on the outcome of standardised assays. (oecd.org)
Irritation1
Tumor5
  • and Armitage, 1955, Biometrics 11, 375-386) is routinely applied to carcinogenicity data as a test for linear trend in lifetime tumor incidence rates. (rti.org)
  • This technique is compared to that of Bailer and Portier (1988, Biometrics 44, 417-431), who introduced a survival-adjusted quantal response test for trend in lifetime tumor incidence rates. (rti.org)
  • Although the delta method approach is slightly more computationally intensive, small-sample simulations indicate that it has superior operating characteristics over the Poly-3 trend test of Bailer and Portier when background tumor incidence rates are low (under 3%) and survival patterns differ markedly across treatments. (rti.org)
  • tumor development following carcinogen exposure," which demonstrate equivalent performance with the standard two-year tests. (taconic.com)
  • Our standardized measure of carcinogenic potency, TD 50 , is the daily dose rate in mg/kg body weight/day to induce tumors in half of test animals that would have remained tumor-free at zero dose. (nih.gov)
Mutagenic1
Assay2
  • mouse lymphoma assay (MLA) otherwise known as in vitro mammalian cell clastogenecity, the Bruce Ames test (Ames test) and mouse micronuclei assay. (ukessays.com)
  • The test is a colorimetric assay which measures the expression of genes induced by genotoxic agents in Escherichia coli, by means of a fusion with the structural gene for β-galactosidase. (wikipedia.org)
Target organs2
Vivo6
Organs1
Exposure1
Evaluation3
20161
Chronic4
19781
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/4251262 Title: Bioassay of 1-phenyl-2-thiourea for possible carcinogenicity Publisher: Bethesda, Md. : U.S. Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, 1978. (worldcat.org)
Mechanisms1
Bacterial2
  • and (ii) to review and revise WHO guidelines on laboratory and field testing of chemical and bacterial larvicides and insect growth regulators (IGRs) against mosquito larvae. (who.int)
  • The Group also reviewed and revised the draft guidelines on laboratory and field testing of chemical and bacterial larvicides and insect growth regulators against mosquito larvae, to be published as a separate document by WHOPES. (who.int)
Species4
  • Over the past century these and other species have been used to advance our knowledge of disease, to test new drugs, and to assure their safety before moving into the clinical phase with human subjects. (taconic.com)
  • It has not been adequately tested in other species. (inchem.org)
  • If the CPDB has no experiments in the sex-species group, "no test" appears. (nih.gov)
  • Only tests with dosing for at least ¼ the standard lifespan of the species and experiment length at least ½ the lifespan are included in the CPDB. (nih.gov)
Systemic toxicity1
Genotoxicity tests1
  • As bacteria or cultured mammalian cells used in the in vitro genotoxicity tests have limited capacity for metabolizing drugs, several types of the metabolic activation systems are applied to the in vitro test systems. (go.jp)
Data5
  • The document is not proscriptive but provides suggestions for possible next steps in testing (if any) which might be appropriate for a regulatory authority to take, given the various data scenarios. (oecd.org)
  • All available (eco)toxicological data from standardized or non-standardized tests. (oecd.org)
  • Since the chemical tested may inhibit protein synthesis at higher concentrations, which would lead to an underestimation of B-galactosidase induction, alkaline phosphatase is assayed simultaneously with β-galactosidase in order to scale the data to survivability of the cells. (wikipedia.org)
  • A method for comparing and combining short-term genotoxicity test data: the basic system. (nih.gov)
  • Data on health effects in humans are confined to patch tests demonstrating skin sensitization in some subjects. (powells.com)
Studies6
Dose-response3
Hazards1
Laboratory3
  • His laboratory was connected with her apartments by a secret passageway, so that no formulae could be stolen en route. (wikipedia.org)
  • Laboratory tests performed on whole blood specimens and includes the following: White blood cell count (WBC), hematocrit (Hct), red blood cell count (RBC), hemoglobin (Hgb), differential count of white blood cells, red blood cell morphology, red blood cell indices, and platelet count. (wa.gov)
  • MC has been tested for carcinogenicity in several laboratory rodents. (osha.gov)
Evaluate1
  • The National Library of Medicine does not test products nor does it evaluate information from the product label or the (M)SDS. (nih.gov)
Reproductive1
Experimental2
  • The multiplicity of comparisons has given rise to concern that individual Fisher-Irwin tests could seriously overstate the experimental evidence in some situations. (nih.gov)
  • Target sites are listed if any author of published experimental results concluded that tumors were induced in that organ by the test agent. (nih.gov)
Animal9
  • This paper demonstrates the use of the delta method for estimating the variance of ratio statistics derived from animal carcinogenicity experiments. (rti.org)
  • Their test modifies the usual Cochran-Armitage computing formula by weighting the denominators of the response rates to reflect less-than-whole-animal contributions to risk. (rti.org)
  • The Tg rasH2/CB6F1 mouse seems to be a promising candidate as an animal model for the development of a rapid carcinogenicity testing system. (nii.ac.jp)
  • The literature on carcinogenicity, including the epidemiologic literature and animal bioassays, is then reviewed. (nap.edu)
  • The Foundation for Biomedical Research website has a table listing the animals behind top drugs and a comprehensive summary of how animal testing and research has advanced human health. (taconic.com)
  • Early identification of drugs that will fail testing in higher level animal models or clinical trials, lowers the over-all cost of drug development. (taconic.com)
  • GEN Exclusives has published an article by Amar Thyagarajan, PhD, Senior Product Manager at Taconic Biosciences, titled New Guidelines Involve the Testing Done on Animal Models . (taconic.com)
  • One of the first priorities set by ECVAM was the implementation of procedures which would enable it to become well-informed about the state-of-the-art of non-animal test development and validation and the potential for the possible incorporation of alternative tests into regulatory procedures. (jhsph.edu)
  • Animal testing is on the way out, as new testing technology starts to take over. (europa.eu)
Ames3
Carcinogenesis2
OECD Test Guidelines1
  • some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers). (oecd.org)
Assessment4
Concern1
  • ACD/Labs Package for Toxicity Screening of Impurities provides a battery of in silico tests to accurately assess the genotoxic and carcinogenic potential of impurities and degradants, found to be below the threshold of toxicological concern in drug products, helping companies remain compliant with regulatory submission requirements. (acdlabs.com)
Study2
Damage2
  • Genotoxicity test is carried out so as to determine whether the anti-arthritis drug can cause genetic damage. (ukessays.com)
  • These tests detects whether the anti-arthritis can cause alterations in chromosome and damage to DNA leading to genetic mutation and ultimately results in malignant tumour (cancerous cell). (ukessays.com)
Human3
  • Human papillomavirus testing is now included for management of atypical glandular cytology, for follow-up after treatment for cervical intraepithelial neoplasia, and in combination with cytologic screening in women 30 years and older. (aafp.org)
  • The preferred management of atypical squamous cells of undetermined significance in adult women is reflex human papillomavirus DNA testing. (aafp.org)
  • Updated guidelines published in October 2007 place greater emphasis on testing for high-risk human papillomavirus (HPV). (aafp.org)
Mammalian1
Guidance5
  • On August 18, 2015, FDA issued the final guidance Select Updates for Non-Clinical Engineering Tests and Recommended Labeling for Intravascular Stents and Associated Delivery Systems which updates and augments (but not replaces) this guidance. (fda.gov)
  • This document supersedes the guidance "Non-Clinical Engineering Tests and Recommended Labeling for Intravascular Stents and Associated Delivery Systems" dated January 13, 2005. (fda.gov)
  • This guidance provides FDA's current thinking on non-clinical engineering tests that are submitted in investigational device exemption applications (IDEs) and premarket approval applications (PMAs) to support the safety and effectiveness of intravascular stents and their associated delivery systems. (fda.gov)
  • The document is intended to provide guidance for evaluating chemical using standardised test guidelines. (oecd.org)
  • Further information regarding the use and interpretation of these tests is available in Guidance Document No. 150. (oecd.org)
Lung2
  • Meanwhile, several short-termin vitroandin vivostudies that may be useful to assess the relative potential of fibrous substances to cause lung toxicity/carcinogenicity have been identified. (cdc.gov)
  • Only a very few lung adenomas but no other tumors were seen as spontaneous tumors during the months of carcnogenicity tests. (nii.ac.jp)
Approaches1
  • These modelling approaches will reduce the dependence on the use of animals as well as the costs associated with toxicity tests, and will have wide-ranging applications. (europa.eu)
Potential2
Animals2
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The International Program for the Evaluation of Short-Term Tests for Carcinogenicity (IPESTTC) | SpringerLink
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Chemicals That Cause Cancer Getting 'Benefit of the Doubt' - The Washington Post
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Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer | Toxicology |...
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4 Genotoxicity and Carcinogenicity | Health Effects of Beryllium Exposure: A Literature Review | The National Academies Press
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RTECS:TX8750000 - Propane, 1,2-dibromo-3-chloro- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
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Tobacco's Belated Confessions - Mother Jones
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Perfume - Wikipedia
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Reaction mass of cobalt and copper and iron - Registration Dossier - ECHA
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Febuxostat - DrugBank
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Bethanechol - DrugBank
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Cinnarizine - DrugBank
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Dezocine - DrugBank
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Ketoprofen - DrugBank
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Mifepristone - DrugBank
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