Carcinogenesis. Medical search

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

The combination of two or more different factors in the production of cancer.

7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.

Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)

A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.

A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)

Tumors or cancer of the SKIN.

A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.

Tumors or cancer of the COLON.

Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.

A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.

Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Tumors or cancer of the STOMACH.

A malignant epithelial tumor with a glandular organization.

A benign epithelial tumor with a glandular organization.

A potent mutagen and carcinogen. This compound and its metabolite 4-HYDROXYAMINOQUINOLINE-1-OXIDE bind to nucleic acids. It inactivates bacteria but not bacteriophage.

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

Experimentally induced tumors of the LIVER.

A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

A substituted carcinogenic nitrosamine.

Carcinogenic substances that are found in the environment.

Hydrazines substituted with two methyl groups in any position.

A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.

A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.

Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.

A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.

A cell line derived from cultured tumor cells.

Tumors or cancer of the MOUTH.

Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.

An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.

The use of chemical compounds to prevent the development of a specific disease.

Tumors or cancer of the LUNG.

Tumors or cancer of the LIVER.

The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Tumors or cancer of the INTESTINES.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.

Antibiotic substance produced by various Streptomyces species. It is an inhibitor of enzymatic activities that involve glutamine and is used as an antineoplastic and immunosuppressive agent.

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.

Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.

Tumors or cancer of the URINARY BLADDER.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Tumors or cancer of the ESOPHAGUS.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.

DNA present in neoplastic tissue.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Regular course of eating and drinking adopted by a person or animal.

Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.

Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.

That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.

Mutant strains of mice that produce little or no hair.

Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

Tumors or cancer of the PROSTATE.

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Hydrazines substituted by one or more methyl groups in any position.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

Tumors or cancer of the UTERINE CERVIX.

A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.

The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).

The part of the face that is below the eye and to the side of the nose and mouth.

MAMMARY GLANDS in the non-human MAMMALS.

Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.

A nucleoside consisting of the base guanine and the sugar deoxyribose.

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.

Tumors or cancer of the human BREAST.

Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.

Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.

Tumors or cancer of the TONGUE.

A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.

A di-tert-butyl PHENOL with antioxidant properties.

A condition in which there is a change of one adult cell type to another similar adult cell type.

Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

A sulfanilamide that is used as an anti-infective agent.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Elements of limited time intervals, contributing to particular results or situations.

One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.

Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Interruption or suppression of the expression of a gene at transcriptional or translational levels.

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.

A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.

A potent nitrofuran derivative tumor initiator. It causes bladder tumors in all animals studied and is mutagenic to many bacteria.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.

2- or 4-Hydroxyestrogens. Substances that are physiologically active in mammals, especially in the control of gonadotropin secretion. Physiological activity can be ascribed to either an estrogenic action or interaction with the catecholaminergic system.

A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

RNA present in neoplastic tissue.

A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Endogenous factors or drugs that increase the transport and metabolism of LIPIDS including the synthesis of LIPOPROTEINS by the LIVER and their uptake by extrahepatic tissues.

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.

Tumors or cancers of the KIDNEY.

A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.

The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.

A reagent used mainly to induce experimental liver cancer. According to the Fourth Annual Report on Carcinogens (NTP 85-002, p. 89) published in 1985, this compound "may reasonably be anticipated to be a carcinogen." (Merck, 11th ed)

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Organic compounds with the general formula R-NCS.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.

In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES.

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.

The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.

A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.

A very potent liver carcinogen.

A carcinogen that is often used in experimental cancer studies.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.

Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.

Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.

Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.

The measurement of an organ in volume, mass, or heaviness.

A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.

Any horny growth such as a wart or callus.

Flavoring agent and non-nutritive sweetener.

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.

A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.

Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.

A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).

The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.

Additive SMILES-based carcinogenicity models: Probabilistic principles in the search for robust predictions. (1/423)

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Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis. (2/423)

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Lewis Y promotes growth and adhesion of ovarian carcinoma-derived RMG-I cells by upregulating growth factors. (3/423)

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Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. (4/423)

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The propensity for tumorigenesis in human induced pluripotent stem cells is related with genomic instability. (5/423)

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The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. (6/423)

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Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor. (7/423)

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Eicosanoid profiling in colon cancer: emergence of a pattern. (8/423)

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This model of carcinogenesis is popular because it explains why cancers grow. It would be expected that cells that are damaged ... Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed ... Furthermore, in light of the Darwinistic mechanisms of carcinogenesis, it has been theorized that the various forms of cancer ... López-Lázaro M (March 2010). "A new view of carcinogenesis and an alternative approach to cancer therapy". Molecular Medicine. ...

https://en.wikipedia.org/wiki/Carcinogenesis

... is a series of genotypic and/or phenotypic changes in the cells of a fetus due to in utero ... Donovan PJ (June 1999). "Cell sensitivity to transplacental carcinogenesis by N-ethyl-N-nitrosourea is greatest in early post- ... Alexandrov V, Aiello C, Rossi L (1990). "Modifying factors in prenatal carcinogenesis (review)". In Vivo. 4 (5): 327-35. PMID ... Magee PN (October 1975). "Transplacental carcinogenesis". Proc. R. Soc. Med. 68 (10): 655-7. PMC 1864063. PMID 1208519. ( ...

https://en.wikipedia.org/wiki/Transplacental_carcinogenesis

Carcinogenesis, 1 (1), retrieved 17 August 2010[dead link] Harris CC. (2008), "Editorial", Carcinogenesis, 29: 1, doi:10.1093/ ... Carcinogenesis is a peer-reviewed medical journal in the field of cancer biology. It was established in 1980 and is published ... Carcinogenesis is abstracted and indexed in Biological Abstracts, BIOSIS Previews, CAB Abstracts, Chemical Abstracts, Current ... 2010), "Editorial", Carcinogenesis, 31: 1, doi:10.1093/carcin/bgp302, archived from the original on 22 February 2010, retrieved ...

https://en.wikipedia.org/wiki/Carcinogenesis_(journal)

The Journal of Carcinogenesis is a peer-reviewed open access medical journal published by Medknow Publications on behalf of the ... Carcinogenesis Press. The journal covers research in oncology. The journal is abstracted and indexed in: Abstracts on Hygiene ...

https://en.wikipedia.org/wiki/Journal_of_Carcinogenesis

This is now widely accepted, and part of the mainstream view of carcinogenesis. In their original paper, they found that r {\ ... The Armitage-Doll model is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, in which ... Armitage, P. and Doll, R. (1954) "The Age Distribution of Cancer and a Multi-Stage Theory Of Carcinogenesis", British Journ. of ... 33(6): 1183-1184 doi:10.1093/ije/dyh359 v t e v t e (Carcinogenesis, Medical statistics, All stub articles, Oncology stubs, ...

https://en.wikipedia.org/wiki/Armitage–Doll_multistage_model_of_carcinogenesis

However, in contrast to α-catenin, heightened β-catenin levels may be associated with carcinogenesis. In particular, abnormal ... Carcinogenesis. 33 (3): 637-43. doi:10.1093/carcin/bgr306. PMID 22198215. Song S, Christova T, Perusini S, Alizadeh S, Bao RY, ...

https://en.wikipedia.org/wiki/Catenin

November 2010). "Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal Melanoma". Invest ... Carcinogenesis. 31 (5): 864-70. doi:10.1093/carcin/bgq051. PMC 2864416. PMID 20197299. Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q ... suggesting that methylation of miRNA is an early event in colorectal carcinogenesis. Analysis of promoter methylation in oral ... "Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis". Cancer Res. 70 (16): 6609-18. doi:10.1158/0008 ...

https://en.wikipedia.org/wiki/MiR-137

Carcinogenesis. 32 (1): 27-34. doi:10.1093/carcin/bgq216. PMID 20974687. Siddiqui A, Tumiati M, Joko A, Sandholm J, Roering P, ...

https://en.wikipedia.org/wiki/ABL_(gene)

Newberne Paul M., Wogan Gerald N. (1968). "Sequential Morphologic Changes in Aflatoxin B1 Carcinogenesis in the Rat". Cancer ... Semela, Maryann (2001). "The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis" (PDF). ... Carcinogenesis. 22 (4): 535-545. doi:10.1093/carcin/22.4.535. PMID 11285186. Ross, R. K.; Yuan, J. M.; Yu, M. C.; Wogan, G. N ... Carcinogenesis. 15 (5): 947-55. doi:10.1093/carcin/15.5.947. PMID 8200100. Patterson D.S.P. Aflatoxin and related compounds: ...

https://en.wikipedia.org/wiki/Aflatoxin_B1

Carcinogenesis. 25 (5): 827-31. doi:10.1093/carcin/bgh056. PMID 14688018. Some info on apocarotenal Olson, A.J. (1964). "The ...

https://en.wikipedia.org/wiki/Apocarotenal

Carcinogenesis. 19 (1): 1-27. doi:10.1093/carcin/19.1.1. PMID 9472688. "Human Metabolome Database: Showing metabocard for ...

https://en.wikipedia.org/wiki/Estriol_glucuronide

Carcinogenesis. 28 (3): 560-71. doi:10.1093/carcin/bgl167. PMID 17012225. Ewing RM, Chu P, Elisma F, et al. (2007). "Large- ...

https://en.wikipedia.org/wiki/MAGEB2

Carcinogenesis. 22 (2): 347-9. doi:10.1093/carcin/22.2.347. PMID 11181459. Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev ...

https://en.wikipedia.org/wiki/Cytochrome_p450_family_19_subfamily_a_member_1

Carcinogenesis. 28 (8): 1731-9. doi:10.1093/carcin/bgm111. PMID 17494052. Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman ...

https://en.wikipedia.org/wiki/POLG2

Carcinogenesis. 28 (3): 738-48. doi:10.1093/carcin/bgl180. PMID 17065199. Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon ...

https://en.wikipedia.org/wiki/AP-1_transcription_factor

Carcinogenesis. 20 (4): 651-6. doi:10.1093/carcin/20.4.651. PMID 10223195. v t e (Articles without InChI source, ECHA InfoCard ... in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both ...

https://en.wikipedia.org/wiki/Symmetrical_dimethylhydrazine

Carcinogenesis. 26 (10): 1741-7. doi:10.1093/carcin/bgi126. PMID 15905204. Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, ... fail-safe protection against carcinogenesis. Mutat Res. 2002 Jun;511(2):145-78. doi: 10.1016/s1383-5742(02)00009-1. PMID: ...

https://en.wikipedia.org/wiki/Caretaker_gene

Carcinogenesis. 19 (1): 49-53. doi:10.1093/carcin/19.1.49. PMID 9472692. Coleman RA, Smith WL, Narumiya S (1994). " ...

https://en.wikipedia.org/wiki/Eicosanoid_receptor

Carcinogenesis. 23 (10): 1583-1592. doi:10.1093/carcin/23.10.1583. PMID 12376465. Wikimedia Commons has media related to NR4A1 ...

https://en.wikipedia.org/wiki/Nuclear_receptor_4A1

Carcinogenesis. 29 (12): 2298-305. doi:10.1093/carcin/bgn226. PMID 18845560. Lee LH, Moh MC, Zhang T, Shen S (August 2009). " ...

https://en.wikipedia.org/wiki/HEPACAM

Ultraviolet Radiation Carcinogenesis". In Bast RC, Kufe DW, Pollock RE, et al. (eds.). Holland-Frei Cancer Medicine (5th ed.). ... Many studies of heavy metal-induced carcinogenesis show that such heavy metals cause a reduction in expression of DNA repair ... Carcinogenesis. 27 (12): 2402-08. doi:10.1093/carcin/bgl079. PMC 2612936. PMID 16728433. Tutt AN, van Oostrom CT, Ross GM, van ... Carcinogenesis (review). 30 (7): 1073-81. doi:10.1093/carcin/bgp127. PMID 19468060. Ungefroren H, Sebens S, Seidl D, Lehnert H ...

https://en.wikipedia.org/wiki/Cancer

Carcinogenesis. 17 (12): 2609-15. doi:10.1093/carcin/17.12.2609. PMID 9006096. Crudden G, Loesel R, Craven RJ (2005). " ...

https://en.wikipedia.org/wiki/PGRMC1

Carcinogenesis. 23 (7): 1139-48. doi:10.1093/carcin/23.7.1139. PMID 12117771. "Entrez Gene: PCLKC protocadherin LKC". Yang LY, ...

https://en.wikipedia.org/wiki/PCLKC

Carcinogenesis. 33 (7): 1294-301. doi:10.1093/carcin/bgs179. PMID 22610076. Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, ...

https://en.wikipedia.org/wiki/Mir-572_microRNA_precursor_family

Carcinogenesis. 33 (10): 1833-42. doi:10.1093/carcin/bgs216. PMC 3529556. PMID 22739026. Gupta P, Kim B, Kim SH, Srivastava SK ... Carcinogenesis. 21 (6): 1157-62. doi:10.1093/carcin/21.6.1157. PMID 10837004. Kensler TW, Curphey TJ, Maxiutenko Y, Roebuck BD ...

https://en.wikipedia.org/wiki/Cruciferous_vegetables

Yokota J (March 2000). "Tumor progression and metastasis". Carcinogenesis. 21 (3): 497-503. doi:10.1093/carcin/21.3.497. PMID ...

https://en.wikipedia.org/wiki/Oncogene

Carcinogenesis. 2 (2): 121-7. doi:10.1093/carcin/2.2.121. PMID 7273295. Autier P.; Dore J.-F.; Cesarini J.-P. (1997). "Should ...

https://en.wikipedia.org/wiki/Psoralen

Carcinogenesis. 27 (11): 2308-15. doi:10.1093/carcin/bgl073. PMID 16714329. Meng Q, Raha A, Roy S, Hu J, Kalvakolanu DV (May ...

https://en.wikipedia.org/wiki/MPGES-2

Carcinogenesis. 31 (2): 234-8. doi:10.1093/carcin/bgp287. PMID 19955392. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, ... Carcinogenesis. 30 (6): 987-90. doi:10.1093/carcin/bgp090. PMID 19369581. Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, ... Carcinogenesis. 31 (11): 1977-1981. doi:10.1093/carcin/bgq179. PMC 2966556. PMID 20802237. Petersen GM, Amundadottir L, Fuchs ...

https://en.wikipedia.org/wiki/CLPTM1L

Newborn male B6C3F1 mice". Carcinogenesis. 5 (12): 1623-1628. doi:10.1093/carcin/5.12.1623. PMID 6499113. Apiole Phenylpropene ...

https://en.wikipedia.org/wiki/Dillapiole

Cite this: Role of Alcohol in Liver Carcinogenesis - Medscape - May 01, 2009. ... alcohol not only has the ability to promote carcinogenesis through its own CYP2E1-dependent metabolism per se, but also through ...

https://www.medscape.com/viewarticle/705411_4

Download CCRIS (Chemical Carcinogenesis Research Information System) Data. Terms and Conditions Get the Data via Bulk Download ... Test results have been reviewed by experts in carcinogenesis and mutagenesis.. CCRIS provides historical information from the ...

https://www.nlm.nih.gov/databases/download/ccris.html

... different environmental exposures cause different patterns of DNA methylation in genes that are important in carcinogenesis. ...

https://www.niehs.nih.gov/research/atniehs/labs/epi/pi/molecular/index.cfm

You have to enable JavaScript in your browsers settings in order to use the eReader.. Or try downloading the content offline. DOWNLOAD ...

https://ehp.niehs.nih.gov/doi/epdf/10.1289/ehp.01109209

Full Text PA-95-084 MOLECULAR EPIDEMIOLOGY OF PROSTATE CARCINOGENESIS NIH GUIDE, Volume 24, Number 30, August 18, 1995 PA ... This Program Announcement (PA), Molecular Epidemiology of Prostate Carcinogenesis, is related to the priority area of cancer. ... Selected measurements or biomarkers should be relevant to the processes of prostate carcinogenesis. Additionally, there is a ... David Longfellow Chemical and Physical Carcinogenesis Branch National Cancer Institute Executive Plaza North, Suite 700 ...

https://grants.nih.gov/grants/guide/pa-files/PA-95-084.html

Testing Status of AZT transplacental carcinogenesis study M990048. Testing Status of AZT transplacental carcinogenesis study ... AZT Transplacental Carcinogenesis Study (AIDS Initiative). Long-Term Carcinogenicity. *19 months (In Utero) (C99022) Completed ... Toxicology and Carcinogenesis Studies of Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1®) Mice (in utero Studies) ...

https://ntp.niehs.nih.gov/go/ts-m990048

... Drug Metab Rev. 2000 Aug-Nov;32(3-4):395-411. doi: 10.1081/dmr-100102342. ... These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in ... This review summarizes available data on inhibition of carcinogenesis by isothiocyanates. The major mechanism of inhibition ...

https://pubmed.ncbi.nlm.nih.gov/11139137/?dopt=Abstract

Isaac Brownell, the Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling ... The Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate ... and using mouse genetics to model carcinogenesis in the skin. ... Cutaneous Development and Carcinogenesis Section Isaac Brownell ...

https://www.niams.nih.gov/labs/brownell-lab

The course will examine the role of reactive nitrogen and oxygen species in carcinogenesis, cancer proliferation and ... The course will examine the role of reactive nitrogen and oxygen species in carcinogenesis, cancer proliferation and ...

https://videocast.nih.gov/watch=5346

This application is to renew the T32 ES-09250-30 training grant entitled, "Environmental Carcinogenesis and Mutagenesis" (ECM) ... The ECM training program initially focused exclusively on environmental carcinogenesis and mutagenesis as its title implied. ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.grantDetail&grant_number=T32ES007250

We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using m … ... We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epidemiologic ... Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with ... Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with ...

https://pubmed.ncbi.nlm.nih.gov/32363580/

Ito, N., Fukushima, S., and Tsuda, H. Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants. CRC Crit. Rev. Toxicol., 15(2): 109-150, 1985. ...

http://www.highfiber.com/~galenvtp/vtlrefni.htm

... J Clin Invest. 2008 Feb;118(2):560 ... identify TNF-alpha as a crucial mediator of the initiation and progression of colitis-associated colon carcinogenesis and ...

https://pubmed.ncbi.nlm.nih.gov/18219394/?dopt=Abstract

... Grant Number: ... Project Title: Chemoprevention Efficacy of Sulforaphane Against Obesity-Induced Endometrial Carcinogenesis. Abstract: The ...

https://ods.od.nih.gov/Funding/abstract.aspx?g=3P30CA225520-04S1&print=1

Carcinogenesis funny cartoons from CartoonStock directory - the worlds largest on-line collection of cartoons and comics. ...

https://www.cartoonstock.com/directory/c/carcinogenesis.asp

A new approach to the molecular epidemiologic evaluation of occupational carcinogenesis has become available through the use of ... A new approach to the molecular epidemiologic evaluation of occupational carcinogenesis has become available through the use of ...

https://www.cdc.gov/niosh/nioshtic-2/00200978.html

Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. Primary areas of interest ... A peer reviewed journal in the field of Carcinogenesis and Chemoprevention For the Researchers - By the Researchers - Of the ... processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the ... to the journal include: physical and chemical carcinogenesis and mutagenesis; ...

https://carcinogenesis.com/article/category/issue/vol-3-issue-1

Tumor-associated hypoxia plays an important role in carcinogenesis and metastasis. The expression, activation, and ... Cross-talk between HIF and PD-1/PD-L1 pathways in carcinogenesis and therapy. ... Cross-talk between HIF and PD-1/PD-L1 pathways in carcinogenesis and therapy. ...

https://www.jci.org/articles/view/159473/pdf

Lung cancer is a condition that most commonly observed in people who smoke a lot. In this cancer, abnormal growth of lung tissue is found in the lungs. The..

https://www.omicsonline.org/carcinogenesis-mutagenesis/lung-cancer-top-journals.php

Figure 1 Illustration of the role of histone deacetylase in esophageal carcinogenesis. HDACs: Histone deacetylases; HATs: ... Table 1 summarizes the mechanisms of action of HDACs in carcinogenesis.. Table 1 Histone deacetylase-associated mechanisms of ... In carcinogenesis, evasion of apoptosis remains one of the most important mechanisms contributing to cell immortality. Many ... In carcinogenesis, heat shock proteins, like HSP90, are cellular regulators providing stability to multiple oncogenic proteins ...

https://www.wjgnet.com/1007-9327/full/v24/i41/4635.htm

Carcinogenesis is a word to describe the process of cancer formation. ... Carcinogenesis is a word used to describe the process of cancer formation. A carcinogen is anything that causes cancer. The ...

https://www.doterra.com/SG/en_SG/essential-oil-safety-and-application-toxicity-chemical-carcinogenesis

... the rat esophagus and the golden Syrian hamster trachea carcinogenesis models. In addition, we present results from ,i,ex vivo ... review the application of light scattering to assessing the health status of tissues drawn from animal models of carcinogenesis ... the rat esophagus and the golden Syrian hamster trachea carcinogenesis models. In addition, we present results from ex vivo ... review the application of light scattering to assessing the health status of tissues drawn from animal models of carcinogenesis ...

https://www.hindawi.com/journals/dm/2008/584101/

Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Download ... Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa.. Eur J Cancer ... "Inhibition of Two Stage Renal Carcinogenesis, Oxidative Damage and Hyperproliferative Response By Nigella Sativa." European ... Khan N, Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella ...

https://www.unboundmedicine.com/medline/citation/15785320/Inhibition_of_two_stage_renal_carcinogenesis_oxidative_damage_and_hyperproliferative_response_by_Nigella_sativa_

... ... The peptide hormone gastrin exerts a suppressive effect on antral gastric carcinogenesis. ...

https://pubmed.ncbi.nlm.nih.gov/21111741/?dopt=Abstract

Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. Carcinogenesis. 1993. 14: ... DiGiovanni, J. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 1992. 54:63-128. View this article via: PubMed ... Responsiveness of Stat3-deficient mice to 2-stage carcinogenesis. (A-C) Groups of mice (n = 15) were treated with 25 nmol DMBA ... Carcinogenesis. 1993. 14:2353-2358. View this article via: PubMed CrossRef Google Scholar ...

https://www.jci.org/articles/view/21032

Viral carcinogenesis - Homo sapiens (human) [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show description ...

https://www.kegg.jp/pathway/hsa05203+5829

Viral carcinogenesis - Homo sapiens (human) [ Pathway menu , Pathway entry , Download KGML , Show description , Image file , ...

https://www.kegg.jp/kegg-bin/show_pathway?map=hsa05203&mapscale=1.0&show_description=hide&multi_query=hsa:10488+red,black%0D%0A

Genetics could play an important role in CRC carcinogenesis. The book is regarding the role played by ABCG2 and MDR1 genes in ... Genetics could play an important role in CRC carcinogenesis. The book is regarding the role played by ABCG2 and MDR1 genes in ... colorectal carcinogenesis. Both genes are member of ABC transporter family, which plays an important role in removing ... colorectal carcinogenesis. Both genes are member of ABC transporter family, which plays an important role in removing ...

https://www.buecher.de/shop/englische-buecher/colorectal-carcinogenesis-risk-factors-role-of-abcg2--mdr1-genes/riaz-ramishmasood-nosheen/products_products/detail/prod_id/47025443/

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis S A Baechler 1 , V M Factor 1 , I ... The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis S A Baechler et al. Nat Commun. ... TOP1MT promotes tumor growth in a mouse model of liver carcinogenesis. a Experimental design. Male mice received a single ... TOP1MT promotes tumor growth in a mouse model of liver carcinogenesis. a Experimental… ...

https://www.ncbi.nlm.nih.gov/pubmed/?term=30622257

The overall goal of our carcinogenesis research is to understand the basic cellular and molecular mechanisms that allow the transformation of normal cells into cancer cells. (mdanderson.org)
Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. (ub.edu)
We are pleased to announce the publication of Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis (Smith et al. (who.int)
Slaga, TJ 1981, ' Studies on the mechanisms of action of modifiers of skin carcinogenesis ', Postepy Mikrobiologii , vol. 20, no. 1-2, pp. 113-129. (uthscsa.edu)
The CNSC about revises with Global Affairs Canada in two political only molecular mechanisms of metal toxicity and carcinogenesis flow treatments: the Nuclear remains Group and the Zangger Committee. (huesch.net)
On the molecular mechanisms of metal toxicity and carcinogenesis 2001 of Social Interaction in Individual Agency. (huesch.net)
The mechanisms by which organoselenium compounds inhibit tumor formation during the initiation phase of carcinogenesis have been explored in vitro and in well defined animal model. (rjptonline.org)
In the lecture "Organ Specific Molecular Carcinogenesis" the mechanisms of carcinogenesis and tumor progression of different organs are specifically discussed. (tum.de)
To study the mechanisms of carcinogenesis of ovarian cancer will help us understand this disease and develop new strategies of diagnosis and prevention for ovarian cancer in the future. (knowcancer.com)
Analyzes the modes by which organisms handle damage to DNA by physical and chemical agents, the mechanisms of converting damage to mutations, and the theoretical basis for carcinogenesis screening methods utilizing mutagenesis. (nyu.edu)
IARC coordinates and conducts epidemiological and laboratory research on the causes of human cancer, the mechanisms of carcinogenesis, and develops scientific strategies for cancer control. (bvs.br)

The volume includes sections on ultrasensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, use as biomarkers and their role in mutagenesis and carcinogenesis. (iarc.fr)
Teratogenesis, carcinogenesis, and mutagenesis (Print) / Alan R. Liss. (bvs.br)

Proinflammatory cytokine interleukin-17 (IL-17 or IL-17A) has been shown to play a critical role in colon carcinogenesis in mouse models. (dovepress.com)
Overall, our findings support the concept that perturbations in host-microbiota interactions that cause low-grade gut inflammation can promote colon carcinogenesis. (aacrjournals.org)
Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis. (bvsalud.org)
Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis . (bvsalud.org)

Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
PETA says that the leg hemoglobin that enters the impassable food contains more iron than the hemoglobin that enters the meat, and it can increase the risk of carcinogenesis by excessive iron ingestion. (techrecipe.co.kr)

Sirt3 has also now been identified as a genomically expressed, mitochondrial localized tumor suppressor and this review will outline potential relationships between mitochondrial ROS/superoxide levels, aging, and cell phenotypes permissive for estrogen and progesterone receptor positive breast carcinogenesis. (ewha.ac.kr)
Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)

This non systematic review summarizes current data available on the role of environment gene interaction in form of GSTM1 null polymorphism and oral carcinogenesis. (bvsalud.org)
Relationship between GSTM1 null polymorphism in oral cancer needs to be established to confirm the role of environment gene interaction in oral carcinogenesis. (bvsalud.org)

In conclusion, this large prospective study confirms the important role of HPV and a possible contribution of CT and HHV-2 in cervical carcinogenesis. (elsevier.com)
Limited data are available from prospective studies concerning the role of past exposure to human papillomavirus (HPV) and other infections in cervical carcinogenesis. (elsevier.com)

To identify the genes associated with aberrant DNA hypermethylation in endometrial carcinogenesis, we studied the hypermethylation of the promoter regions of five genes: hMLH1, APC, E-cadherin, RAR-β and p16. (elsevier.com)
The high frequencies of the aberrant DNA hypermethylation of hMLH1 , APC and E-cadherin suggest that the methylation of the DNA mismatch repair and Wnt signal-related genes may be associated with endometrial carcinogenesis. (elsevier.com)
These findings suggest that underexpression of miR-34a might be involved in endometrial carcinogenesis. (koreamed.org)

Inflammation is known to contribute to carcinogenesis in human colorectal cancer. (dovepress.com)
My main surgical specialty is cancer surgery and my academic interest involves basic and clinical research: carcinogenesis, colorectal cancer, molecular radiation biology and radiation enteropathy, as well as palliative medicine and hospice care. (otago.ac.nz)

Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. (bvsalud.org)
Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)

Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. (wineinformationcouncil.eu)

Carcinogenesis - The generation of cancer from normal cells, correctly the formation of a carcinoma from epithelial cells. (creighton.edu)

Emblematic of these is CtsB, reported to play functionally significant roles during pancreatic islet and mammary carcinogenesis. (elsevier.com)
In contrast to these findings, our studies found no significant role for CtsC during mammary carcinogenesis but revealed squamous carcinogenesis to be functionally dependent on CtsC. (elsevier.com)
Insulin-like growth factor binding protein 3 (IGFBP3) plays an important role in cellular proliferation, differentiation, apoptosis, and mammary carcinogenesis. (nih.gov)

Epidemiology and carcinogenesis of hepatocellular carcinoma. (bvsalud.org)

In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. (biogps.org)

Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. (carcinogenesis.com)

Carcinogenesis (2019), Bd. (uni-tuebingen.de)

The development of colitis-associated cancer in patients suffering from inflammatory bowel disease (IBD) is one of the best characterized examples of an association between intestinal inflammation and carcinogenesis ( 4-7 ). (aacrjournals.org)
Histamine deficiency promotes inflammation-associated carcinogenesis t" by Xiang Dong Yang, Walden Ai et al. (uwo.ca)
In mice, TREX2 deficiency led to enhanced susceptibility to UVB-induced skin carcinogenesis which was preceded by aberrant DNA damage removal and degradation as well as reduced inflammation. (ub.edu)
Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 and concomitant nitric oxide (NO) release associated with cancer initiation and progression. (nuigalway.ie)
Furthermore, an isogenic HDC-deficient L. reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, indicating a significant role of the cometabolite, histamine, in suppression of chronic intestinal inflammation and colorectal tumorigenesis. (utmb.edu)

High EGFR expression suggests uncontrolled growth which depicts that EGFR upregulation may be an early event during HNSCC carcinogenesis. (jomfp.in)

Perpetual ROS generation can cause specific molecular changes resulting in the activation or inactivation of transcription factors that may alter gene expression leading to cell proliferation, differentiation, and carcinogenesis. (cdc.gov)

The Molecular Pathogenesis Group has focused on defining the pathogenesis/carcinogenesis of tumors affecting the reproductive tract of rodents and humans, and assessing the role of environmental and endogenous hormonal factors in the growth of these tumors. (nih.gov)
Our research relies on the development of genetically engineered animal models for investigating the stepwise molecular changes that occur during carcinogenesis, the function of key genes and gene variants in cancer development, and preclinical prevention and therapeutic studies. (mdanderson.org)
These preliminary results suggested that mutation of p16 CDKN2A exon 1 might be an early molecular event of rat tongue carcinogenesis induced by 4NQO and G was the mutation hotspot. (umn.edu)
Molecular Carcinogenesis , 46 (2), 85-90. (umn.edu)
The lectures "Molecular Pathology" and "Organ-Specific Molecular Carcinogenesis" will be provided in WS 2022-2023 in face-to-face and/or in digital form as video recordings via Moodle. (tum.de)
The lectures "Molecular Pathology" and "Organ-Specific Molecular Carcinogenesis" are aimed at students of medicine and natural sciences, e.g. biochemistry, biology and molecular biotechnology. (tum.de)

One fundamental observation in cancer etiology is that the rate of malignancies in any mammalian population increases exponentially as a function of age, suggesting a mechanistic link between the cellular processes governing longevity and carcinogenesis. (ewha.ac.kr)
A microRNA, miR-34a, plays a key role in inhibiting cellular transformation and carcinogenesis by controlling cell cycle regulation and cell proliferation in various human tumors. (koreamed.org)

2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. . (oregonstate.edu)

Epigenetic abnormalities including the aberrant DNA hypermethylation of the promoter CpG islands play a key role in the mechanism of gene inactivation in cell carcinogenesis. (elsevier.com)

The host antitumor immunity changes drastically during carcinogenesis. (biogps.org)

The systemic effect of UVB radiation markedly potentiated carcinogenesis at the distant site. (elsevier.com)
These results suggest that the systemic effect of UVB radiation is exerted during the promotion phase of two-stage carcinogenesis. (elsevier.com)
Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system. (twoday.net)

In this study we explored the mutation types of p16 CDKN2A exon 1 and the corresponding frequencies in experimental rat tongue carcinogenesis. (umn.edu)

abstract = "Microbiome-mediated suppression of carcinogenesis may open new avenues for identification of therapeutic targets and prevention strategies in oncology. (utmb.edu)

CtsC, on the other hand, while up-regulated during pancreatic islet carcinogenesis, lacks functional significance in mediating neoplastic progression in that organ. (elsevier.com)

The mechanism of carcinogenesis by the neutral fraction of cigarette smoke condensate. (ox.ac.uk)
Studies elucidating the role of particle size in the biological mechanism of particle-elicited carcinogenesis would be useful. (cdc.gov)

From these studies, it is evident that ROS signaling is critical for the responses of cytokines, growth factors, and activation or inactivation of transcription factors that promote carcinogenesis. (cdc.gov)

Interestingly, three of the seven sirtuin proteins are localized into the mitochondria suggesting a connection between the mitochondrial sirtuins, the free radical theory of aging, and carcinogenesis. (ewha.ac.kr)

The field of carcinogenesis focuses on understanding how a normal cell transforms into a cancer cell. (mit.edu)

Occupational factors in carcinogenesis. (cdc.gov)

Anatomy22

Organisms20

Diseases58

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Health Care3

Additive SMILES-based carcinogenicity models: Probabilistic principles in the search for robust predictions. (1/423)

Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis. (2/423)

Lewis Y promotes growth and adhesion of ovarian carcinoma-derived RMG-I cells by upregulating growth factors. (3/423)

Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. (4/423)

The propensity for tumorigenesis in human induced pluripotent stem cells is related with genomic instability. (5/423)

The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. (6/423)

Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor. (7/423)

Eicosanoid profiling in colon cancer: emergence of a pattern. (8/423)

Carcinogens

Carcinogenesis

Cell Transformation, Neoplastic

Cocarcinogenesis

9,10-Dimethyl-1,2-benzanthracene

Precancerous Conditions

Azoxymethane

Anticarcinogenic Agents

Papilloma

Rats, Inbred F344

Skin Neoplasms

Methylnitrosourea

Colonic Neoplasms

Carcinogenicity Tests

1,2-Dimethylhydrazine

Neoplasms, Experimental

Nitrosamines

Mammary Neoplasms, Experimental

Gene Expression Regulation, Neoplastic

Stomach Neoplasms

Adenocarcinoma

Adenoma

4-Nitroquinoline-1-oxide

Neoplasms, Radiation-Induced

Liver Neoplasms, Experimental

Carcinoma, Squamous Cell

Diethylnitrosamine

Neoplasms

Butylhydroxybutylnitrosamine

Carcinogens, Environmental

Dimethylhydrazines

Methylnitronitrosoguanidine

Benzo(a)pyrene

Genes, ras

Immunohistochemistry

Colorectal Neoplasms

Hyperplasia

Mesocricetus

Cell Line, Tumor

Mouth Neoplasms

DNA Methylation

Cyclooxygenase 2

Chemoprevention

Lung Neoplasms

Liver Neoplasms

Colon

Cell Proliferation

Carcinoma

Apoptosis

Mice, Transgenic

Intestinal Neoplasms

Cell Division

DNA Adducts

Azaserine

Tumor Suppressor Protein p53

DNA Damage

Keratinocytes

Reverse Transcriptase Polymerase Chain Reaction

Urethane

Urinary Bladder Neoplasms

Tumor Markers, Biological

Mutagens

Mutation

2-Acetylaminofluorene

RNA, Messenger

Esophageal Neoplasms

Disease Models, Animal

Genes, Tumor Suppressor

Signal Transduction

Mice, Inbred SENCAR

DNA, Neoplasm

Disease Progression

Genes, p53

Epithelial Cells

Diet

Mutagenicity Tests

Gastric Mucosa

Ultraviolet Rays

Mice, Hairless

Benz(a)Anthracenes