Carcinogens
Carcinogenesis
Cell Transformation, Neoplastic
9,10-Dimethyl-1,2-benzanthracene
Precancerous Conditions
Azoxymethane
Anticarcinogenic Agents
Papilloma
Carcinogenicity Tests
Tests to experimentally measure the tumor-producing/cancer cell-producing potency of an agent by administering the agent (e.g., benzanthracenes) and observing the quantity of tumors or the cell transformation developed over a given period of time. The carcinogenicity value is usually measured as milligrams of agent administered per tumor developed. Though this test differs from the DNA-repair and bacterial microsome MUTAGENICITY TESTS, researchers often attempt to correlate the finding of carcinogenicity values and mutagenicity values.
1,2-Dimethylhydrazine
Neoplasms, Experimental
Nitrosamines
Mammary Neoplasms, Experimental
Gene Expression Regulation, Neoplastic
4-Nitroquinoline-1-oxide
Neoplasms, Radiation-Induced
Carcinoma, Squamous Cell
Neoplasms
Methylnitronitrosoguanidine
Benzo(a)pyrene
Genes, ras
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Immunohistochemistry
Colorectal Neoplasms
Hyperplasia
Mesocricetus
DNA Methylation
Cyclooxygenase 2
Colon
Carcinoma
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Mice, Transgenic
Cell Division
DNA Adducts
Azaserine
Tumor Suppressor Protein p53
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Keratinocytes
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
Reverse Transcriptase Polymerase Chain Reaction
Urethane
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Mutagens
Mutation
2-Acetylaminofluorene
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Disease Models, Animal
Genes, Tumor Suppressor
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred SENCAR
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Disease Progression
Genes, p53
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Mutagenicity Tests
Gastric Mucosa
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Benz(a)Anthracenes
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Intestinal Mucosa
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Liver
Skin
Carcinoma in Situ
Tetradecanoylphorbol Acetate
Dimethylnitrosamine
Epidermis
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Aberrant Crypt Foci
Body Weight
Oncogenes
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Prostaglandin-Endoperoxide Synthases
Genes, APC
Ornithine Decarboxylase
Metaplasia
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Blotting, Western
Benzopyrenes
Loss of Heterozygosity
Tumor Cells, Cultured
Gene Expression Profiling
Epithelium
Alkylating Agents
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Promoter Regions, Genetic
Cricetinae
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Butylated Hydroxyanisole
Dose-Response Relationship, Drug
Genetic Predisposition to Disease
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Papillomaviridae
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
Rats, Inbred Strains
Plant Extracts
Croton Oil
Down-Regulation
Gene Silencing
Tumor Suppressor Proteins
Aflatoxin B1
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
DNA Repair
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p16
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Base Sequence
Glutathione Transferase
Immunoenzyme Techniques
Isoenzymes
Helicobacter Infections
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Models, Biological
CpG Islands
Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.
FANFT
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Oligonucleotide Array Sequence Analysis
Mouth Mucosa
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Estrogens, Catechol
Epigenesis, Genetic
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
Helicobacter pylori
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Prostate
DNA-Binding Proteins
Lipotropic Agents
Antioxidants
Endometrial Neoplasms
Cyclooxygenase 2 Inhibitors
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
p-Dimethylaminoazobenzene
Up-Regulation
DNA Primers
Keratin-14
Breast
MicroRNAs
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Mice, Nude
Tea
Risk Factors
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Disease Susceptibility
Helicobacter felis
Trans-Activators
Gene Expression
Telomerase
Papillomavirus Infections
Oncogene Proteins, Viral
Rats, Sprague-Dawley
Polymorphism, Single-Stranded Conformational
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
Aminobiphenyl Compounds
Leukoplakia
gamma-Glutamyltransferase
Transcription Factors
Human papillomavirus 16
Arsenic
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Barrett Esophagus
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Antimutagenic Agents
Microsatellite Repeats
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Additive SMILES-based carcinogenicity models: Probabilistic principles in the search for robust predictions. (1/423)
(+info)Functional analysis of familial Asp67Glu and Thr1051Ser BRCA1 mutations in breast/ovarian carcinogenesis. (2/423)
(+info)Lewis Y promotes growth and adhesion of ovarian carcinoma-derived RMG-I cells by upregulating growth factors. (3/423)
(+info)Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. (4/423)
(+info)The propensity for tumorigenesis in human induced pluripotent stem cells is related with genomic instability. (5/423)
(+info)The good, the bad and the ugly: epigenetic mechanisms in glioblastoma. (6/423)
(+info)Analysis of a novel highly metastatic melanoma cell line identifies osteopontin as a new lymphangiogenic factor. (7/423)
(+info)Eicosanoid profiling in colon cancer: emergence of a pattern. (8/423)
(+info)
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Carcinogenesis
This model of carcinogenesis is popular because it explains why cancers grow. It would be expected that cells that are damaged ... Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed ... Furthermore, in light of the Darwinistic mechanisms of carcinogenesis, it has been theorized that the various forms of cancer ... López-Lázaro M (March 2010). "A new view of carcinogenesis and an alternative approach to cancer therapy". Molecular Medicine. ...
Transplacental carcinogenesis
... is a series of genotypic and/or phenotypic changes in the cells of a fetus due to in utero ... Donovan PJ (June 1999). "Cell sensitivity to transplacental carcinogenesis by N-ethyl-N-nitrosourea is greatest in early post- ... Alexandrov V, Aiello C, Rossi L (1990). "Modifying factors in prenatal carcinogenesis (review)". In Vivo. 4 (5): 327-35. PMID ... Magee PN (October 1975). "Transplacental carcinogenesis". Proc. R. Soc. Med. 68 (10): 655-7. PMC 1864063. PMID 1208519. ( ...
Carcinogenesis (journal)
Carcinogenesis, 1 (1), retrieved 17 August 2010[dead link] Harris CC. (2008), "Editorial", Carcinogenesis, 29: 1, doi:10.1093/ ... Carcinogenesis is a peer-reviewed medical journal in the field of cancer biology. It was established in 1980 and is published ... Carcinogenesis is abstracted and indexed in Biological Abstracts, BIOSIS Previews, CAB Abstracts, Chemical Abstracts, Current ... 2010), "Editorial", Carcinogenesis, 31: 1, doi:10.1093/carcin/bgp302, archived from the original on 22 February 2010, retrieved ...
Journal of Carcinogenesis
The Journal of Carcinogenesis is a peer-reviewed open access medical journal published by Medknow Publications on behalf of the ... Carcinogenesis Press. The journal covers research in oncology. The journal is abstracted and indexed in: Abstracts on Hygiene ...
Armitage-Doll multistage model of carcinogenesis
This is now widely accepted, and part of the mainstream view of carcinogenesis. In their original paper, they found that r {\ ... The Armitage-Doll model is a statistical model of carcinogenesis, proposed in 1954 by Peter Armitage and Richard Doll, in which ... Armitage, P. and Doll, R. (1954) "The Age Distribution of Cancer and a Multi-Stage Theory Of Carcinogenesis", British Journ. of ... 33(6): 1183-1184 doi:10.1093/ije/dyh359 v t e v t e (Carcinogenesis, Medical statistics, All stub articles, Oncology stubs, ...
Catenin
However, in contrast to α-catenin, heightened β-catenin levels may be associated with carcinogenesis. In particular, abnormal ... Carcinogenesis. 33 (3): 637-43. doi:10.1093/carcin/bgr306. PMID 22198215. Song S, Christova T, Perusini S, Alizadeh S, Bao RY, ...
MiR-137
November 2010). "Epigenetics, MicroRNAs, and Carcinogenesis: Functional Role of MicroRNA-137 in Uveal Melanoma". Invest ... Carcinogenesis. 31 (5): 864-70. doi:10.1093/carcin/bgq051. PMC 2864416. PMID 20197299. Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q ... suggesting that methylation of miRNA is an early event in colorectal carcinogenesis. Analysis of promoter methylation in oral ... "Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis". Cancer Res. 70 (16): 6609-18. doi:10.1158/0008 ...
ABL (gene)
Carcinogenesis. 32 (1): 27-34. doi:10.1093/carcin/bgq216. PMID 20974687. Siddiqui A, Tumiati M, Joko A, Sandholm J, Roering P, ...
Aflatoxin B1
Newberne Paul M., Wogan Gerald N. (1968). "Sequential Morphologic Changes in Aflatoxin B1 Carcinogenesis in the Rat". Cancer ... Semela, Maryann (2001). "The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis" (PDF). ... Carcinogenesis. 22 (4): 535-545. doi:10.1093/carcin/22.4.535. PMID 11285186. Ross, R. K.; Yuan, J. M.; Yu, M. C.; Wogan, G. N ... Carcinogenesis. 15 (5): 947-55. doi:10.1093/carcin/15.5.947. PMID 8200100. Patterson D.S.P. Aflatoxin and related compounds: ...
Apocarotenal
Carcinogenesis. 25 (5): 827-31. doi:10.1093/carcin/bgh056. PMID 14688018. Some info on apocarotenal Olson, A.J. (1964). "The ...
Estriol glucuronide
Carcinogenesis. 19 (1): 1-27. doi:10.1093/carcin/19.1.1. PMID 9472688. "Human Metabolome Database: Showing metabocard for ...
MAGEB2
Carcinogenesis. 28 (3): 560-71. doi:10.1093/carcin/bgl167. PMID 17012225. Ewing RM, Chu P, Elisma F, et al. (2007). "Large- ...
Cytochrome p450 family 19 subfamily a member 1
Carcinogenesis. 22 (2): 347-9. doi:10.1093/carcin/22.2.347. PMID 11181459. Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev ...
POLG2
Carcinogenesis. 28 (8): 1731-9. doi:10.1093/carcin/bgm111. PMID 17494052. Huang H, Shiffman ML, Cheung RC, Layden TJ, Friedman ...
AP-1 transcription factor
Carcinogenesis. 28 (3): 738-48. doi:10.1093/carcin/bgl180. PMID 17065199. Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon ...
Symmetrical dimethylhydrazine
Carcinogenesis. 20 (4): 651-6. doi:10.1093/carcin/20.4.651. PMID 10223195. v t e (Articles without InChI source, ECHA InfoCard ... in a rat model of colorectal carcinogenesis: fermentable fibre confers greater protection than non-fermentable fibre in both ...
Caretaker gene
Carcinogenesis. 26 (10): 1741-7. doi:10.1093/carcin/bgi126. PMID 15905204. Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, ... fail-safe protection against carcinogenesis. Mutat Res. 2002 Jun;511(2):145-78. doi: 10.1016/s1383-5742(02)00009-1. PMID: ...
Eicosanoid receptor
Carcinogenesis. 19 (1): 49-53. doi:10.1093/carcin/19.1.49. PMID 9472692. Coleman RA, Smith WL, Narumiya S (1994). " ...
Nuclear receptor 4A1
Carcinogenesis. 23 (10): 1583-1592. doi:10.1093/carcin/23.10.1583. PMID 12376465. Wikimedia Commons has media related to NR4A1 ...
HEPACAM
Carcinogenesis. 29 (12): 2298-305. doi:10.1093/carcin/bgn226. PMID 18845560. Lee LH, Moh MC, Zhang T, Shen S (August 2009). " ...
Cancer
Ultraviolet Radiation Carcinogenesis". In Bast RC, Kufe DW, Pollock RE, et al. (eds.). Holland-Frei Cancer Medicine (5th ed.). ... Many studies of heavy metal-induced carcinogenesis show that such heavy metals cause a reduction in expression of DNA repair ... Carcinogenesis. 27 (12): 2402-08. doi:10.1093/carcin/bgl079. PMC 2612936. PMID 16728433. Tutt AN, van Oostrom CT, Ross GM, van ... Carcinogenesis (review). 30 (7): 1073-81. doi:10.1093/carcin/bgp127. PMID 19468060. Ungefroren H, Sebens S, Seidl D, Lehnert H ...
PGRMC1
Carcinogenesis. 17 (12): 2609-15. doi:10.1093/carcin/17.12.2609. PMID 9006096. Crudden G, Loesel R, Craven RJ (2005). " ...
PCLKC
Carcinogenesis. 23 (7): 1139-48. doi:10.1093/carcin/23.7.1139. PMID 12117771. "Entrez Gene: PCLKC protocadherin LKC". Yang LY, ...
Mir-572 microRNA precursor family
Carcinogenesis. 33 (7): 1294-301. doi:10.1093/carcin/bgs179. PMID 22610076. Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, ...
Cruciferous vegetables
Carcinogenesis. 33 (10): 1833-42. doi:10.1093/carcin/bgs216. PMC 3529556. PMID 22739026. Gupta P, Kim B, Kim SH, Srivastava SK ... Carcinogenesis. 21 (6): 1157-62. doi:10.1093/carcin/21.6.1157. PMID 10837004. Kensler TW, Curphey TJ, Maxiutenko Y, Roebuck BD ...
Oncogene
Yokota J (March 2000). "Tumor progression and metastasis". Carcinogenesis. 21 (3): 497-503. doi:10.1093/carcin/21.3.497. PMID ...
Psoralen
Carcinogenesis. 2 (2): 121-7. doi:10.1093/carcin/2.2.121. PMID 7273295. Autier P.; Dore J.-F.; Cesarini J.-P. (1997). "Should ...
MPGES-2
Carcinogenesis. 27 (11): 2308-15. doi:10.1093/carcin/bgl073. PMID 16714329. Meng Q, Raha A, Roy S, Hu J, Kalvakolanu DV (May ...
CLPTM1L
Carcinogenesis. 31 (2): 234-8. doi:10.1093/carcin/bgp287. PMID 19955392. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, ... Carcinogenesis. 30 (6): 987-90. doi:10.1093/carcin/bgp090. PMID 19369581. Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, ... Carcinogenesis. 31 (11): 1977-1981. doi:10.1093/carcin/bgq179. PMC 2966556. PMID 20802237. Petersen GM, Amundadottir L, Fuchs ...
Dillapiole
Newborn male B6C3F1 mice". Carcinogenesis. 5 (12): 1623-1628. doi:10.1093/carcin/5.12.1623. PMID 6499113. Apiole Phenylpropene ...
Role of Alcohol in Liver Carcinogenesis
Download Chemical Carcinogenesis Research Information System (CCRIS) Data
Molecular & Genetic Epidemiology Group - Environmental Exposure & Carcinogenesis
Sawmill chemicals and carcinogenesis.
NIH Guide: MOLECULAR EPIDEMIOLOGY OF PROSTATE CARCINOGENESIS
Full Text PA-95-084 MOLECULAR EPIDEMIOLOGY OF PROSTATE CARCINOGENESIS NIH GUIDE, Volume 24, Number 30, August 18, 1995 PA ... This Program Announcement (PA), Molecular Epidemiology of Prostate Carcinogenesis, is related to the priority area of cancer. ... Selected measurements or biomarkers should be relevant to the processes of prostate carcinogenesis. Additionally, there is a ... David Longfellow Chemical and Physical Carcinogenesis Branch National Cancer Institute Executive Plaza North, Suite 700 ...
AZT transplacental carcinogenesis study M990048
Testing Status of AZT transplacental carcinogenesis study M990048. Testing Status of AZT transplacental carcinogenesis study ... AZT Transplacental Carcinogenesis Study (AIDS Initiative). Long-Term Carcinogenicity. *19 months (In Utero) (C99022) Completed ... Toxicology and Carcinogenesis Studies of Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1®) Mice (in utero Studies) ...
Inhibition of carcinogenesis by isothiocyanates
... Drug Metab Rev. 2000 Aug-Nov;32(3-4):395-411. doi: 10.1081/dmr-100102342. ... These naturally occurring isothiocyanates as well as many synthetic analogs can be powerful inhibitors of carcinogenesis in ... This review summarizes available data on inhibition of carcinogenesis by isothiocyanates. The major mechanism of inhibition ...
Cutaneous Development and Carcinogenesis Section | NIAMS
Isaac Brownell, the Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling ... The Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate ... and using mouse genetics to model carcinogenesis in the skin. ... Cutaneous Development and Carcinogenesis Section Isaac Brownell ...
NIH VideoCast - Redox Biology: Physiology - Carcinogenesis
ENVIRONMENTAL CARCINOGENESIS AND MUTAGENESIS
Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with...
We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using m … ... We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epidemiologic ... Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with ... Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral-host interaction with ...
Antioxidant Carcinogenesis
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
Grant Abstract: Chemoprevention Efficacy of Sulforaphane Against Obesity-Induced Endometrial Carcinogenesis
Carcinogenesis Cartoons and Comics - funny pictures from CartoonStock
NIOSHTIC-2 Publications Search - 00200978 - Oncogene proteins as biomarkers in the molecular epidemiology of occupational...
Vol 3, Issue 1 - Carcinogenesis
Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. Primary areas of interest ... A peer reviewed journal in the field of Carcinogenesis and Chemoprevention For the Researchers - By the Researchers - Of the ... processes influencing or modulating carcinogenesis, such as DNA repair; genetics, nutrition, and metabolism of carcinogens; the ... to the journal include: physical and chemical carcinogenesis and mutagenesis; ...
JCI -
Cross-talk between HIF and PD-1/PD-L1 pathways in carcinogenesis and therapy
Lung Cancer Top Journals| OMICS International|Carcinogenesis And Mutagenesis
Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment
Figure 1 Illustration of the role of histone deacetylase in esophageal carcinogenesis. HDACs: Histone deacetylases; HATs: ... Table 1 summarizes the mechanisms of action of HDACs in carcinogenesis.. Table 1 Histone deacetylase-associated mechanisms of ... In carcinogenesis, evasion of apoptosis remains one of the most important mechanisms contributing to cell immortality. Many ... In carcinogenesis, heat shock proteins, like HSP90, are cellular regulators providing stability to multiple oncogenic proteins ...
Part 2: Toxicity-Chemical Carcinogenesis | dōTERRA Essential Oils
In Situ Nuclear Morphology Measurements Using Light Scattering as Biomarkers of Neoplastic Change in Animal Models of...
... the rat esophagus and the golden Syrian hamster trachea carcinogenesis models. In addition, we present results from ,i,ex vivo ... review the application of light scattering to assessing the health status of tissues drawn from animal models of carcinogenesis ... the rat esophagus and the golden Syrian hamster trachea carcinogenesis models. In addition, we present results from ex vivo ... review the application of light scattering to assessing the health status of tissues drawn from animal models of carcinogenesis ...
PRIME PubMed | Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa
Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Download ... Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa.. Eur J Cancer ... "Inhibition of Two Stage Renal Carcinogenesis, Oxidative Damage and Hyperproliferative Response By Nigella Sativa." European ... Khan N, Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella ...
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
JCI -
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. Carcinogenesis. 1993. 14: ... DiGiovanni, J. Multistage carcinogenesis in mouse skin. Pharmacol. Ther. 1992. 54:63-128. View this article via: PubMed ... Responsiveness of Stat3-deficient mice to 2-stage carcinogenesis. (A-C) Groups of mice (n = 15) were treated with 25 nmol DMBA ... Carcinogenesis. 1993. 14:2353-2358. View this article via: PubMed CrossRef Google Scholar ...
KEGG PATHWAY: Viral carcinogenesis - Homo sapiens (human)
KEGG PATHWAY: Viral carcinogenesis - Homo sapiens (human)
Colorectal Carcinogenesis, Risk Factors, Role of ABCG2 & MDR1 Genes von Ramish Riaz; Nosheen Masood - englisches Buch - bücher...
Genetics could play an important role in CRC carcinogenesis. The book is regarding the role played by ABCG2 and MDR1 genes in ... Genetics could play an important role in CRC carcinogenesis. The book is regarding the role played by ABCG2 and MDR1 genes in ... colorectal carcinogenesis. Both genes are member of ABC transporter family, which plays an important role in removing ... colorectal carcinogenesis. Both genes are member of ABC transporter family, which plays an important role in removing ...
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis - PubMed
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis S A Baechler 1 , V M Factor 1 , I ... The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis S A Baechler et al. Nat Commun. ... TOP1MT promotes tumor growth in a mouse model of liver carcinogenesis. a Experimental design. Male mice received a single ... TOP1MT promotes tumor growth in a mouse model of liver carcinogenesis. a Experimental… ...
MechanismsMutagenesisColonRisk of carcinogenesisTumorOral CarcinogenesisCervical carcinogenesisEndometrial carcinogenesisColorectal cancerCarcinogensInducesEpithelial cellsMammaryHepatocellular CarcinomaMultistepChemoprevention2019InflammationUpregulationDifferentiationMolecularCellularExpressionAberrantImmunityRadiationExperimentalAbstractSignificanceMechanismStudiesProteinsCellOccupational
Mechanisms11
- The overall goal of our carcinogenesis research is to understand the basic cellular and molecular mechanisms that allow the transformation of normal cells into cancer cells. (mdanderson.org)
- Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. (ub.edu)
- We are pleased to announce the publication of Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis (Smith et al. (who.int)
- Slaga, TJ 1981, ' Studies on the mechanisms of action of modifiers of skin carcinogenesis ', Postepy Mikrobiologii , vol. 20, no. 1-2, pp. 113-129. (uthscsa.edu)
- The CNSC about revises with Global Affairs Canada in two political only molecular mechanisms of metal toxicity and carcinogenesis flow treatments: the Nuclear remains Group and the Zangger Committee. (huesch.net)
- On the molecular mechanisms of metal toxicity and carcinogenesis 2001 of Social Interaction in Individual Agency. (huesch.net)
- The mechanisms by which organoselenium compounds inhibit tumor formation during the initiation phase of carcinogenesis have been explored in vitro and in well defined animal model. (rjptonline.org)
- In the lecture "Organ Specific Molecular Carcinogenesis" the mechanisms of carcinogenesis and tumor progression of different organs are specifically discussed. (tum.de)
- To study the mechanisms of carcinogenesis of ovarian cancer will help us understand this disease and develop new strategies of diagnosis and prevention for ovarian cancer in the future. (knowcancer.com)
- Analyzes the modes by which organisms handle damage to DNA by physical and chemical agents, the mechanisms of converting damage to mutations, and the theoretical basis for carcinogenesis screening methods utilizing mutagenesis. (nyu.edu)
- IARC coordinates and conducts epidemiological and laboratory research on the causes of human cancer, the mechanisms of carcinogenesis, and develops scientific strategies for cancer control. (bvs.br)
Mutagenesis2
- The volume includes sections on ultrasensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, use as biomarkers and their role in mutagenesis and carcinogenesis. (iarc.fr)
- Teratogenesis, carcinogenesis, and mutagenesis (Print) / Alan R. Liss. (bvs.br)
Colon4
- Proinflammatory cytokine interleukin-17 (IL-17 or IL-17A) has been shown to play a critical role in colon carcinogenesis in mouse models. (dovepress.com)
- Overall, our findings support the concept that perturbations in host-microbiota interactions that cause low-grade gut inflammation can promote colon carcinogenesis. (aacrjournals.org)
- Ginsenoside Rb1 Suppresses AOM/DSS-Induced Colon Carcinogenesis. (bvsalud.org)
- Ginsenoside Rb1 significantly attenuated AOM/DSS-induced colon carcinogenesis . (bvsalud.org)
Risk of carcinogenesis2
- Mutations in genes concerned with production of enzymes for metabolism of tobacco products may lead to increased risk of carcinogenesis with respect to oral mucosa. (bvsalud.org)
- PETA says that the leg hemoglobin that enters the impassable food contains more iron than the hemoglobin that enters the meat, and it can increase the risk of carcinogenesis by excessive iron ingestion. (techrecipe.co.kr)
Tumor2
- Sirt3 has also now been identified as a genomically expressed, mitochondrial localized tumor suppressor and this review will outline potential relationships between mitochondrial ROS/superoxide levels, aging, and cell phenotypes permissive for estrogen and progesterone receptor positive breast carcinogenesis. (ewha.ac.kr)
- Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
Oral Carcinogenesis2
- This non systematic review summarizes current data available on the role of environment gene interaction in form of GSTM1 null polymorphism and oral carcinogenesis. (bvsalud.org)
- Relationship between GSTM1 null polymorphism in oral cancer needs to be established to confirm the role of environment gene interaction in oral carcinogenesis. (bvsalud.org)
Cervical carcinogenesis2
- In conclusion, this large prospective study confirms the important role of HPV and a possible contribution of CT and HHV-2 in cervical carcinogenesis. (elsevier.com)
- Limited data are available from prospective studies concerning the role of past exposure to human papillomavirus (HPV) and other infections in cervical carcinogenesis. (elsevier.com)
Endometrial carcinogenesis3
- To identify the genes associated with aberrant DNA hypermethylation in endometrial carcinogenesis, we studied the hypermethylation of the promoter regions of five genes: hMLH1, APC, E-cadherin, RAR-β and p16. (elsevier.com)
- The high frequencies of the aberrant DNA hypermethylation of hMLH1 , APC and E-cadherin suggest that the methylation of the DNA mismatch repair and Wnt signal-related genes may be associated with endometrial carcinogenesis. (elsevier.com)
- These findings suggest that underexpression of miR-34a might be involved in endometrial carcinogenesis. (koreamed.org)
Colorectal cancer2
- Inflammation is known to contribute to carcinogenesis in human colorectal cancer. (dovepress.com)
- My main surgical specialty is cancer surgery and my academic interest involves basic and clinical research: carcinogenesis, colorectal cancer, molecular radiation biology and radiation enteropathy, as well as palliative medicine and hospice care. (otago.ac.nz)
Carcinogens2
- Carcinogenesis is a multistep process and individual risk to development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on genetic susceptibility of an individual. (bvsalud.org)
- Therefore variations in the expression of these genes due to heritable genetic polymorphisms might modulate the process of carcinogenesis by altering the exposure levels of tobacco derived carcinogens. (bvsalud.org)
Induces1
- Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. (wineinformationcouncil.eu)
Epithelial cells1
- Carcinogenesis - The generation of cancer from normal cells, correctly the formation of a carcinoma from epithelial cells. (creighton.edu)
Mammary3
- Emblematic of these is CtsB, reported to play functionally significant roles during pancreatic islet and mammary carcinogenesis. (elsevier.com)
- In contrast to these findings, our studies found no significant role for CtsC during mammary carcinogenesis but revealed squamous carcinogenesis to be functionally dependent on CtsC. (elsevier.com)
- Insulin-like growth factor binding protein 3 (IGFBP3) plays an important role in cellular proliferation, differentiation, apoptosis, and mammary carcinogenesis. (nih.gov)
Hepatocellular Carcinoma1
- Epidemiology and carcinogenesis of hepatocellular carcinoma. (bvsalud.org)
Multistep1
- In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. (biogps.org)
Chemoprevention1
- Journal of Carcinogenesis considers manuscripts in many areas of carcinogenesis and Chemoprevention. (carcinogenesis.com)
20191
- Carcinogenesis (2019), Bd. (uni-tuebingen.de)
Inflammation5
- The development of colitis-associated cancer in patients suffering from inflammatory bowel disease (IBD) is one of the best characterized examples of an association between intestinal inflammation and carcinogenesis ( 4-7 ). (aacrjournals.org)
- Histamine deficiency promotes inflammation-associated carcinogenesis t" by Xiang Dong Yang, Walden Ai et al. (uwo.ca)
- In mice, TREX2 deficiency led to enhanced susceptibility to UVB-induced skin carcinogenesis which was preceded by aberrant DNA damage removal and degradation as well as reduced inflammation. (ub.edu)
- Inflammation has been implicated in prostate carcinogenesis, with the overexpression of NOS2 and concomitant nitric oxide (NO) release associated with cancer initiation and progression. (nuigalway.ie)
- Furthermore, an isogenic HDC-deficient L. reuteri mutant that was unable to generate histamine did not suppress carcinogenesis, indicating a significant role of the cometabolite, histamine, in suppression of chronic intestinal inflammation and colorectal tumorigenesis. (utmb.edu)
Upregulation1
- High EGFR expression suggests uncontrolled growth which depicts that EGFR upregulation may be an early event during HNSCC carcinogenesis. (jomfp.in)
Differentiation1
- Perpetual ROS generation can cause specific molecular changes resulting in the activation or inactivation of transcription factors that may alter gene expression leading to cell proliferation, differentiation, and carcinogenesis. (cdc.gov)
Molecular6
- The Molecular Pathogenesis Group has focused on defining the pathogenesis/carcinogenesis of tumors affecting the reproductive tract of rodents and humans, and assessing the role of environmental and endogenous hormonal factors in the growth of these tumors. (nih.gov)
- Our research relies on the development of genetically engineered animal models for investigating the stepwise molecular changes that occur during carcinogenesis, the function of key genes and gene variants in cancer development, and preclinical prevention and therapeutic studies. (mdanderson.org)
- These preliminary results suggested that mutation of p16 CDKN2A exon 1 might be an early molecular event of rat tongue carcinogenesis induced by 4NQO and G was the mutation hotspot. (umn.edu)
- Molecular Carcinogenesis , 46 (2), 85-90. (umn.edu)
- The lectures "Molecular Pathology" and "Organ-Specific Molecular Carcinogenesis" will be provided in WS 2022-2023 in face-to-face and/or in digital form as video recordings via Moodle. (tum.de)
- The lectures "Molecular Pathology" and "Organ-Specific Molecular Carcinogenesis" are aimed at students of medicine and natural sciences, e.g. biochemistry, biology and molecular biotechnology. (tum.de)
Cellular2
- One fundamental observation in cancer etiology is that the rate of malignancies in any mammalian population increases exponentially as a function of age, suggesting a mechanistic link between the cellular processes governing longevity and carcinogenesis. (ewha.ac.kr)
- A microRNA, miR-34a, plays a key role in inhibiting cellular transformation and carcinogenesis by controlling cell cycle regulation and cell proliferation in various human tumors. (koreamed.org)
Expression1
- 2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. . (oregonstate.edu)
Aberrant1
- Epigenetic abnormalities including the aberrant DNA hypermethylation of the promoter CpG islands play a key role in the mechanism of gene inactivation in cell carcinogenesis. (elsevier.com)
Immunity1
- The host antitumor immunity changes drastically during carcinogenesis. (biogps.org)
Radiation3
- The systemic effect of UVB radiation markedly potentiated carcinogenesis at the distant site. (elsevier.com)
- These results suggest that the systemic effect of UVB radiation is exerted during the promotion phase of two-stage carcinogenesis. (elsevier.com)
- Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system. (twoday.net)
Experimental1
- In this study we explored the mutation types of p16 CDKN2A exon 1 and the corresponding frequencies in experimental rat tongue carcinogenesis. (umn.edu)
Abstract1
- abstract = "Microbiome-mediated suppression of carcinogenesis may open new avenues for identification of therapeutic targets and prevention strategies in oncology. (utmb.edu)
Significance1
- CtsC, on the other hand, while up-regulated during pancreatic islet carcinogenesis, lacks functional significance in mediating neoplastic progression in that organ. (elsevier.com)
Mechanism2
Studies1
- From these studies, it is evident that ROS signaling is critical for the responses of cytokines, growth factors, and activation or inactivation of transcription factors that promote carcinogenesis. (cdc.gov)
Proteins1
- Interestingly, three of the seven sirtuin proteins are localized into the mitochondria suggesting a connection between the mitochondrial sirtuins, the free radical theory of aging, and carcinogenesis. (ewha.ac.kr)
Cell1
- The field of carcinogenesis focuses on understanding how a normal cell transforms into a cancer cell. (mit.edu)
Occupational1
- Occupational factors in carcinogenesis. (cdc.gov)