AnatomyChemicals and Drugs
Carboxypeptidase HCarboxypeptidasesMannoheptuloseChromaffin GranulesCarboxypeptidase BCarboxypeptidases ALysine CarboxypeptidaseCathepsin A
Carboxypeptidase H
A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine cells. It catalyzes the cleavage of C-terminal ARGININE or LYSINE residues from polypeptides and is active in processing precursors of PEPTIDE HORMONES and other bioactive peptides.
Carboxypeptidases
Enzymes that act at a free C-terminus of a polypeptide to liberate a single amino acid residue.
Mannoheptulose
A 7-carbon keto sugar having the mannose configuration.
Chromaffin Granules
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
Carboxypeptidase B
A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the preferential cleavage of a C-terminal peptidyl-L-lysine or arginine. It was formerly classified as EC 3.4.2.2 and EC 3.4.12.3.
Carboxypeptidases A
Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-terminal amino acids. Carboxypeptidases A have little or no activity for hydrolysis of C-terminal ASPARTIC ACID; GLUTAMIC ACID; ARGININE; LYSINE; or PROLINE. This enzyme requires ZINC as a cofactor and was formerly listed as EC 3.4.2.1 and EC 3.4.12.2.
Lysine Carboxypeptidase
A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with preference shown for lysine over arginine. It is a plasma zinc enzyme that inactivates bradykinin and anaphylatoxins.
Cathepsin A
A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. It also plays a role in the LYSOSOMES by protecting BETA-GALACTOSIDASE and NEURAMINIDASE from degradation. It was formerly classified as EC 3.4.12.1 and EC 3.4.21.13.

Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway. (1/106)

Several recently discovered members of the carboxypeptidase E (CPE) gene family lack critical active site residues that are conserved in other family members. For example, three CPE-like proteins contain a Tyr in place of Glu300 (equivalent to Glu270 of carboxypeptidase A and B). To investigate the importance of this position, Glu300 of rat CPE was converted into Gln, Lys, or Tyr, and the proteins expressed in Sf9 cells using the baculovirus system. All three mutants were secreted from the cells, but the media showed no enzyme activity above background levels. Wild-type CPE and the Gln300 point mutant bound to a p-aminobenzoyl-Arg-Sepharose affinity resin, and this binding was competed by an active site-directed inhibitor, guanidinoethylmercaptosuccinic acid. The affinity purified mutant CPE protein showed no detectable enzyme activity (<0.004% of wild-type CPE) toward dansyl-Phe-Ala-Arg. Expression of the Gln300 and Lys300 mutant CPE proteins in the NIT3 mouse pancreatic beta-cell line showed that these mutants are routed into secretory vesicles and secreted via the regulated pathway. Taken together, these results indicate that Glu300 of CPE is essential for enzyme activity, but not required for substrate binding or for routing into the regulated secretory pathway.  (+info)

Biosynthesis and packaging of carboxypeptidase D into nascent secretory vesicles in pituitary cell lines. (2/106)

Metallocarboxypeptidase D (CPD) is a membrane-bound trans-Golgi network (TGN) protein. In AtT-20 cells, CPD is initially produced as a 170-kDa endoglycosidase H-sensitive glycoprotein. Within 30 min of chase, the CPD increases to 180 kDa and is resistant to endoglycosidase H as a result of carbohydrate maturation. CPD also undergoes an activation step required for binding to a substrate affinity resin. Blocking the protein exit from the endoplasmic reticulum inhibits the increase in molecular mass but not the step required for affinity column binding, suggesting that enzyme activation precedes carbohydrate maturation and that these reactions occur in distinct intracellular compartments. Only the higher molecular weight mature CPD enters nascent secretory vesicles, which bud from the TGN of permeabilized AtT-20 and GH3 cells. The budding efficiency of CPD into vesicles is 2-3-fold lower than that of endogenous proopiomelanocortin in AtT-20 cells or prolactin in GH3 cells. In contrast, the packaging of a truncated form of CPD, which lacks the cytoplasmic tail and transmembrane domain, was similar to that of proopiomelanocortin. Taken together, the results support the proposal that CPD functions in the TGN in the processing of proteins that transit the secretory pathway and that the C-terminal region plays a major role in TGN retention.  (+info)

Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. (3/106)

Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E, a neuropeptide-processing enzyme. These peptides are produced from a single precursor, termed proSAAS, which is present in human, mouse, and rat. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. When expressed in AtT-20 cells, proSAAS is secreted via the regulated pathway and is also processed at paired-basic cleavage sites into smaller peptides. Overexpression of proSAAS in the AtT-20 cells substantially reduces the rate of processing of the endogenous prohormone proopiomelanocortin. Purified proSAAS inhibits prohormone convertase 1 activity with an IC(50) of 590 nM but does not inhibit prohormone convertase 2. Taken together, proSAAS may represent an endogenous inhibitor of prohormone convertase 1.  (+info)

Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor. (4/106)

Membrane carboxypeptidase E (CPE) is a sorting receptor for targeting prohormones, such as pro-opiomelanocortin, to the regulated secretory pathway in endocrine cells. Its membrane association is necessary for it to bind a prohormone sorting signal at the trans-Golgi network (TGN) to facilitate targeting. In this study, we examined the lipid interaction of CPE in bovine pituitary secretory granule membranes, which are derived from the TGN. We show that CPE is associated with detergent-resistant lipid domains, or rafts, within secretory granule membranes. Lipid analysis revealed that these rafts are enriched in glycosphingolipids and cholesterol. Pulse-chase and subcellular fractionation experiments in AtT-20 cells show that the association of CPE with membrane rafts occurred only after it reached the Golgi. Cholesterol depletion resulted in dissociation of CPE from secretory granule membranes and decreased the binding of prohormones to membranes. In vivo cholesterol depletion using lovastatin resulted in the lack of sorting of CPE and its cargo to the regulated secretory pathway. We propose that the sorting receptor function of CPE necessitates its interaction with glycosphingolipid-cholesterol rafts at the TGN, thereby anchoring it in position to bind to its prohormone cargo.  (+info)

Oligomerization of pro-opiomelanocortin is independent of pH, calcium and the sorting signal for the regulated secretory pathway. (5/106)

Studies indicate that pro-opiomelanocortin (POMC) is sorted to the regulated secretory pathway by binding to a sorting receptor identified as membrane-bound carboxypeptidase E (CPE) [Cool et al. (1997) Cell 88, 73-83]. The efficiency of this sorting mechanism could be enhanced if POMC molecules were to self-associate to form oligomers, prior or subsequent to binding to CPE. Using cross-linking and gel filtration techniques, we demonstrated that POMC forms oligomers at both neutral and acidic pHs and calcium was not necessary. delta N-POMC, which lacks the N-terminal sorting signal for the regulated secretory pathway, also formed similar oligomers, indicating that the sorting and oligomerization domains are different.  (+info)

Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. (6/106)

A spontaneous point mutation in the coding region of the carboxypeptidase E (CPE) gene results in a loss of CPE activity that correlates with the development of late onset obesity (Nagert, J. K., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouille, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J., and Leiter, E. H. (1995) Nat. Genet. 10, 135-142). Examination of the level of neuropeptides in these mice showed a decrease in mature bioactive peptides as a result of a decrease in both carboxypeptidase and prohormone convertase activities. A defect in CPE is not expected to affect endoproteolytic processing. In this report we have addressed the mechanism of this unexpected finding by directly examining the expression of the major precursor processing endoproteases, prohormone convertases PC1 and PC2 in Cpe(fat) mice. We found that the levels of PC1 and PC2 are differentially altered in a number of brain regions and in the pituitary. Since these enzymes have been implicated in the generation of neuroendocrine peptides (dynorphin A-17, beta-endorphin, and alpha- melanocyte-stimulating hormone) involved in the control of feeding behavior and body weight, we compared the levels of these peptides in Cpe(fat) and wild type animals. We found a marked increase in the level of dynorphin A-17, a decrease in the level of alpha-melanocyte-stimulating hormone, and an alteration in the level of C-terminally processed beta-endorphin. These results suggest that the impairment in the level of these and other peptides involved in body weight regulation is mainly due to an alteration in carboxypeptidase and prohormone convertase activities and that this may lead to the development of obesity in these animals.  (+info)

ProSAAS processing in mouse brain and pituitary. (7/106)

ProSAAS is a newly discovered protein with a neuroendocrine distribution generally similar to that of prohormone convertase 1 (PC1), a peptide-processing endopeptidase. Several proSAAS-derived peptides were previously identified in the brain and pituitary of the Cpe(fat)/Cpe(fat) mouse based on the accumulation of C-terminally extended peptides due to the absence of enzymatically active carboxypeptidase E, a peptide-processing exopeptidase. In the present study, antisera against different regions of proSAAS were used to develop radioimmunoassays and examine the processing profile of proSAAS in wild type and Cpe(fat)/Cpe(fat) mouse tissues following gel filtration and reverse phase high performance liquid chromatography. In wild type mouse brain and pituitary, the majority of proSAAS is processed into smaller peptides. These proSAAS-derived peptides elute from the reverse-phase column in the same positions as synthetic peptides that correspond to little SAAS, PEN, and big LEN. Mass spectrometry revealed the presence of peptides with the expected molecular masses of little SAAS and big LEN in the fractions containing immunoreactive peptides. The processing of proSAAS is slightly impaired in Cpe(fat)/Cpe(fat) mice, relative to wild-type mice, leading to the accumulation of partially processed peptides. One of these peptides, the C-terminally extended form of PEN, is known to inhibit PC1 activity and this could account for the reduction in enzymatically active PC1 seen in Cpe(fat)/Cpe(fat) mice. The observation that little SAAS and big LEN are the major forms of these peptides produced in mouse brain and pituitary raises the possibility that these peptides function as neurotransmitters or hormones.  (+info)

Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. (8/106)

Enlarged fat cells exhibit modified metabolic capacities, which could be involved in the metabolic complications of obesity at the whole body level. We show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in enlarged adipocytes. Within a particular fat pad, larger adipocytes have reduced membrane cholesterol concentrations compared with smaller fat cells, demonstrating that altered cholesterol distribution is characteristic of adipocyte hypertrophy per se. We show that treatment with methyl-beta-cyclodextrin, which mimics the membrane cholesterol reduction of hypertrophied adipocytes, induces insulin resistance. We also produced cholesterol depletion by mevastatin treatment, which activates SREBP-2 and its target genes. The analysis of 40 adipocyte genes showed that the response to cholesterol depletion implicated genes involved in cholesterol traffic (caveolin 2, scavenger receptor BI, and ATP binding cassette 1 genes) but also adipocyte-derived secretion products (tumor necrosis factor alpha, angiotensinogen, and interleukin-6) and proteins involved in energy metabolism (fatty acid synthase, GLUT 4, and UCP3). These data demonstrate that altering cholesterol balance profoundly modifies adipocyte metabolism in a way resembling that seen in hypertrophied fat cells from obese rodents or humans. This is the first evidence that intracellular cholesterol might serve as a link between fat cell size and adipocyte metabolic activity.  (+info)

Cloning and sequence analysis of cDNA for bovine carboxypeptidase E<...Cloning and sequence analysis of cDNA for bovine carboxypeptidase E<...
TY - JOUR. T1 - Cloning and sequence analysis of cDNA for bovine carboxypeptidase E. AU - Fricker, Lloyd D.. AU - Evans, Chris J.. AU - Esch, Fred S.. AU - Herbert, Edward. PY - 1986/12/1. Y1 - 1986/12/1. N2 - Carboxypeptidase E (enkephalin convertase) was first identified as the carboxypeptidase B-like enzyme involved in the biosynthesis of enkephalin in bovine adrenal chromaffin granules1. A similar enzyme is present in many brain regions1,2 and in purified secretory granules from rat pituitary3 and rat insulinoma4. Within the secretory granules, carboxypeptidase E (CPE) activity is found in both a soluble and a membrane-bound form1, which differ slightly in relative molecular mass (Mr)5. Here, to investigate whether the CPE activities in the various tissues are produced from a single gene, purified CPE was partially sequenced and oligonucleotide probes were used to isolate a clone encoding CPE from a bovine pituitary complementary DNA library. This cDNA hybridizes to bovine pituitary poly(A)+ ...
https://einstein.pure.elsevier.com/en/publications/cloning-and-sequence-analysis-of-cdna-for-bovine-carboxypeptidase-2
Carboxypeptidase E - WikipediaCarboxypeptidase E - Wikipedia
50) was found to have a mutation that deleted nearly the entire CPE gene. This patient had intellectual disability (inability to read or write) and had abnormal glucose homeostasis, similar to mice lacking CPE activity. In obesity, high levels of circulating free fatty acids have been reported to cause a decrease in the amount of carboxypeptidase E protein in pancreatic beta-cells, leading to beta-cell dysfunction (hyperproinsulinemia) and increased beta-cell apoptosis (via an increase in ER-stress). However, because CPE is not a rate-limiting enzyme for the production of most neuropeptides and peptide hormones, it is not clear how relatively modest decreases in CPE activity can cause physiological effects. Carboxypeptidase Carboxypeptidase A GRCh38: Ensembl release 89: ENSG00000109472 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000037852 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Entrez Gene: CPE carboxypeptidase E. Fricker LD (1988). ...
https://en.wikipedia.org/wiki/Carboxypeptidase_E
Quantitation of neuropeptides in Cpe<sup>fat</sup>/Cpe<sup>fat</sup> mice using differential isotopic tags and...Quantitation of neuropeptides in Cpe<sup>fat</sup>/Cpe<sup>fat</sup> mice using differential isotopic tags and...
TY - JOUR. T1 - Quantitation of neuropeptides in Cpefat/Cpefat mice using differential isotopic tags and mass spectrometry. AU - Che, Fa yun. AU - Fricker, Lloyd D.. PY - 2002/7/1. Y1 - 2002/7/1. N2 - Neuroendocrine peptides play important roles as intercellular messengers. We previously developed a technique to isolate and identify a large number of neuroendocrine peptides from Cpefat/Cpefat mice (Che, F.; et al. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 9971-6); these mice lack carboxypeptidase E activity and this defect causes an accumulation of neuropeptide intermediates that contain C-terminal Lys or Arg residues (Naggert, J. K.; et al. Nat. Genet. 1995, 10, 135-42). In the present study, we have developed a differential isotopic-labeling technique that can be used to quantitate changes in neuropeptide levels in Cpefat/Cpefat mouse tissues. Samples are treated with either the H6 or the D6 form of acetic anhydride, peptides that contain C-terminal basic amino acids are isolated by affinity ...
https://einstein.pure.elsevier.com/en/publications/quantitation-of-neuropeptides-in-cpesupfatsupcpesupfatsup-mice-us
Carboxypeptidase E (CPE) is a prohormone/proneuropeptide handling enzyme and mice bearing - How NF-B is activated: the role of...
Carboxypeptidase E (CPE) is a prohormone/proneuropeptide handling enzyme and mice bearing CPE mutations display an obese and diabetic phenotype. The melanocortin and neuropeptide Y (NPY) systems in the hypothalamus are also implicated in bone tissue redecorating since MC4R KO and NPY KO mice possess elevated BMD. However reduced amount of α-MSH the principal ligand of MC4R by up to 94% AZD2014 and having less detectable NPY in the hypothalamus of CPE KO usually do not ACAD9 recapitulate the single-gene KO phenotypes. This research highlights the complicated physiological interplay between peptides involved with energy fat burning capacity and bone tissue formation and moreover suggests the chance that sufferers bearing CPE and CART mutations resulting in inactive types of these substances could be at an increased threat of developing osteoporosis. carboxypeptidase E (CPE) is normally a digesting enzyme thats highly portrayed in endocrine cells and peptidergic neurons (17 19 It features to ...
http://cancercurehere.com/?p=2070
2-Guanidinoethylmercaptosuccinic Acid - CAS 77482-44-1 - Calbiochem CAS 77482-44-1 | 3693342-Guanidinoethylmercaptosuccinic Acid - CAS 77482-44-1 - Calbiochem CAS 77482-44-1 | 369334
2-Guanidinoethylmercaptosuccinic Acid - CAS 77482-44-1 - Calbiochem CAS 77482-44-1 Potent inhibitor of a carboxypeptidase B-like processing enzyme referred to as enkephalin convertase (Ki = 8.8 nM). - Find MSDS or SDS, a COA, data sheets and more information.
https://www.merckmillipore.com/TW/zh/product/2-Guanidinoethylmercaptosuccinic-Acid-CAS-77482-44-1-Calbiochem,EMD_BIO-369334
DI-fusion Cloning of candidate autoantigen carboxypeptidase H from a...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/56295/Details
Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity...Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity...
Pauls, D., et al. Drosophila carboxypeptidase D (SILVER) is a key enzyme in neuropeptide processing required to maintain locomotor activity levels and survival rate. 10.1111/ejn.14516. Neuropeptides are processed from larger preproproteins by a dedicated set of enzymes. The molecular and biochemical mechanisms underlying preproprotein processing and the functional importance of processing enzymes are well‐characterised in mammals, but little studied outside this group. In contrast to mammals, Drosophila melanogaster lacks a gene for carboxypeptidase E (CPE), a key enzyme for mammalian peptide processing. By combining peptidomics and neurogenetics, we addressed the role of carboxypeptidase D (dCPD) in global neuropeptide processing and selected peptide‐regulated behaviours in Drosophila. We found that a deficiency in dCPD results in C‐terminally extended peptides across the peptidome, suggesting that dCPD took over CPE function in the fruit fly. dCPD is widely expressed throughout the ...
https://www.bioinfor.com/drosophila-carboxypeptidase-d-silver-key-enzyme-neuropeptide-processing-required-maintain-locomotor-activity-levels-survival-rate/
CPE carboxypeptidase E [Homo sapiens (human)] - Gene - NCBICPE carboxypeptidase E [Homo sapiens (human)] - Gene - NCBI
This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015 ...
https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/gene?Db=gene&DbFrom=geoprofiles&Cmd=Link&LinkName=geoprofiles_gene&IdsFromResult=121142166
CPE Enzyme Human Recombinant | Carboxypeptidase E | ProSpecCPE Enzyme Human Recombinant | Carboxypeptidase E | ProSpec
CPE Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 457 amino acids and having a molecular mass of 51.4kDa.
https://www.prospecbio.com/cpe_human
Acceptable CPE activities for certificate renewal | TCTAAcceptable CPE activities for certificate renewal | TCTA
If you have a standard renewable certificate or you have voluntarily opted in to the certificate renewal system, you must obtain CPE from an SBEC-approved provider to renew your certificate. Existing school district-provided in-service should count toward the CPE requirement, as may other activities such as college coursework, professional seminars, mentoring and self-directed study. TCTA is an SBEC-approved provider. Members can earn CPE hours through TCTAs free online seminars.. One semester credit hour earned at an accredited institution of higher education is equivalent to 15 CPE clock hours.. Other than hours needed to comply with required topics for CPE (see below), CPE activities must be related to the certificate(s) being renewed and focus on the standards required for issuance of the certificate(s), including:. ...
https://www.tcta.org/professional-resources/preparation-certification/acceptable-cpe-activities-for-certificate-renewal
NIT-2 ATCC ® CRL-2364™ Mus musculus, transgenic for SV40 laNIT-2 ATCC ® CRL-2364™ Mus musculus, transgenic for SV40 la
The NIT-2 cell line was derived from the pancreatic beta cells of Cpe(fat)/Cpe(fat) mice by crossing C57BLKS/J-Cpe(fat)/+ mice with NOD/Lt-Tg(RIPTag)1Lt mice. The NIT-2 cell line was cultured from adenomatous islets obtained from a 10 week old F2 male and was compared with the NIT-1 cell line (ATCC-CRL-2055) previously developed from mice with wild-type CPE.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Pancreas/CRL-2364.aspx
Kexin - WikipediaKexin - Wikipedia
Kexin (EC 3.4.21.61) is a prohormone processing protease found in the budding yeast (S. cerevisiae). It catalyzes the cleavage of -Lys-Arg- and -Arg-Arg- bonds to process yeast alpha-factor pheromone and killer toxin precursors. The enzyme is encoded by the yeast gene KEX2, and usually referred to in the scientific community as Kex2p. It shares structural similarities with the bacterial protease subtilisin. The first mammalian homologue of this protein to be identified was furin. The enzyme is also known as yeast KEX2 protease, proteinase yscF, prohormone-processing endoprotease, paired-basic endopeptidase, yeast cysteine proteinase F, paired-basic endopeptidase, andrenorphin-Gly-generating enzyme, endoproteinase Kex2p, gene KEX2 dibasic proteinase, Kex 2p proteinase, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, proteinase Kex2p, Kex2-like precursor protein processing endoprotease, prohormone-processing KEX2 proteinase, prohormone-processing proteinase, proprotein ...
https://en.wikipedia.org/wiki/Kexin
Karboksipeptidaza E - WikipediaKarboksipeptidaza E - Wikipedia
Qian, Y.M., Varlamov, O. and Fricker, L.D. (1999). Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway. J. Biol. Chem. 274: 11582-11586. PMID 10206965. ...
https://sh.wikipedia.org/wiki/Karboksipeptidaza_E
Online Hormone Action Part J: Neuroendocrine Peptides
39; legislative Up With All The Home Runs? 39; courts What They were OutSwimming In Schools Gives Fish An Energy Boost3 min father In Schools Gives Fish An Energy BoostDo The Right Thing At Work? is On This Belief2 min readDo The Right Thing At Work?
http://290ster.de/frequenz/mambots/freebook.php?q=online-Hormone-Action-Part-J%3A-Neuroendocrine-Peptides/
Coolsculpting | Remove Stubborn Fat | Fat Freezing | SilkorCoolsculpting | Remove Stubborn Fat | Fat Freezing | Silkor
Learn more about Coolsculpting. Forget about liposuction, this new safe non- surgical body contouring, and sculpting procedure freezes unwanted fat away.
https://www.silkor.com/iraq/en/service/coolsculpting/
Poses with a small penis and abdomen - The Best Way To F*ck When Youre Fat - Fat Guys Guide
12 Yoga Poses For A Flatter Belly Get the abs of your dreams with this revolutionary hybrid yoga workout By The Editors of Prevention April 11,
http://275323.tk/and/poses-with-a-small-penis-and-abdomen.html
Toilet Humor And The HOW vs. WHY Of Getting Fat - Fat HeadToilet Humor And The HOW vs. WHY Of Getting Fat - Fat Head
You ever go to a big party, go to the bathroom, flush the toilet, and the water starts coming … up? This is the most frightening moment in the life of a human being. Youll do anything to stop this. Youll lose your mind and start talking to the toilet: No, please, dont do this to me. No, come on, you know this is not my responsibility! I didnt make this happen! - Jerry Seinfeld. Of course you caused it to happen, Jerry. You flushed the toilet, which filled the bowl with water. More water went into the bowl than went out, and so it overflowed. Call any reputable plumber and ask why a toilet overflows, and thats the answer youll get: more water going in than going out.. Heh-heh-heh … just kidding. A reputable plumber would explain that something has clogged up the system, then charge you a hefty hourly fee to fix the clog.. Back in my standup days, I opened a few times for a comedian I really liked named Tom Parks. He had a good bit about his toilet backing up into his bathtub. (I dont ...
https://www.fathead-movie.com/index.php/2014/11/03/toilet-humor-and-the-how-vs-why-of-getting-fat/
Kindkes Scrap Notes: Stuffed with fat and insulin Resis..........Er Sensitive!
These fat greedy little beasties had reduced energy expenditure, and massive stores of ectopic fat, I.E. massive stores of fat in other places other than adipose tissue, aswell as increased circulating free fatty acids ( compared to mutant ATGL -/- mice that were fed a low-fat diet ). This is certainly what most top doctors would call a lipotoxic environment, and these greedy fat mice should be intensely diabetic. Theres just one problem ...
http://kindkehealthnotes.blogspot.co.uk/2012/04/stuffed-with-fat-and-insulin-resiser.html
Leptin - linked to ability to or not to lose weight
Lets start with the basics of what leptin is and what it does. It is known as the satiety hormone and this might help give you an idea of what it does. This is a hormone that inhibits hunger to help regulate energy balance. Heres the thing about this type of hormone, it has an antagonist, or a hormone that does the exact opposite, that is to make us feel hungry. The body works in this way to maintain a balance. This hormone is called ghrelin, the hunger hormone.. The problem with diets is that people think of them as a short-term plan that they will abandon once the fitness goal is achieved. They do not really make any lasting changes to their lifestyles. The other issue is that whenever you apply certain stress to the body, the body will always respond to compensate for any loss. In other words, if you make your body hungry, it will react by finding mechanisms to keep the energy balance, therefore, making you hungrier.. When leptin was first found to make fat mice lose weight, it was ...
http://mommacandoit.com/diet/leptin-linked-to-ability-to-or-not-to-lose-weight.html
Сыромоноедение | Running on Empty - СыромоноедениеСыромоноедение | Running on Empty - Сыромоноедение
As often happens with nutrition research, results from fasting research have been borrowed and packaged into ill-informed fad diets. Pandas research formed the basis of one such product, branded as The 8-Hour Diet. The book, cowritten by an editor at Mens Health, which covered Pandas research when it came out in 2012, claimed (right on the cover) that dieters who restricted their food consumption to an eight-hour window every day could watch the pounds disappear without watching what you eat! This idea, says Panda-who was not involved in producing the book-was unsupported by his research as of 2012. We never claimed that we could make fat mice lean with the eight-hour diet, he says. In our first paper, we just prevented obesity from happening.. Nevertheless, Panda has gone on to show that there may be some substance to the weight-loss hype. In addition to his experiments in mice, Pandas team found that flies, too, experienced benefits from restricting their feeding windows to a ...
http://syromonoed.com/running-on-empty/
Wash Park Prophet: Gut Bacteria Based Obesity Treatment Works In MiceWash Park Prophet: Gut Bacteria Based Obesity Treatment Works In Mice
In yet another set of experiments, the researchers fed mice a high-fat diet and allowed them to fully develop metabolic syndrome and obesity. Then they gave them the IAP supplement for six weeks. In these animals, IAP reduced endotoxin levels, inflammation and glucose intolerance. If the fat mice had taken the supplement for a longer period of time, their condition may have reversed even more ...
https://washparkprophet.blogspot.com/2013/04/gut-bacteria-based-obesity-treatment.html
Confessions of a Dilettante: I Am Not a Ninja, Repeat, I Am Not a NinjaConfessions of a Dilettante: I Am Not a Ninja, Repeat, I Am Not a Ninja
If there is one thing I have learned about my Husband over the years, it is this: Dont mess with his sleep. He is one of those individuals that requires at least eight hours a night, where as I can go on five and be all right. I have a video of him when I was about eight months pregnant and I have snuck into our bedroom while he is still asleep and am attempting to get him to wake up. I am saying all manner of nice and tempting things to get him to get up; offers of hot food drenched in syrup, mountain biking, nothing works. You finally see the corner of the pillow that is covering his head lift up and a voice comes out of the darkness underneath. He says, NO, Its too EFFING COLD OUTSIDE, NOW TAKE YOUR LITTLE DOG AND LEAVE ME ALONE. I WANT TO SLEEP. And then I can be heard doing what during my pregnancy Jeremy referred to as the Fat mouse Gus from Cinderella chuckle ...
http://www.buttonsmcsweet.com/2008/08/i-am-not-ninja-repeat-i-am-not-ninja.html
Daniel Gemsa: Actor, Extra and Model - London, UK - StarNowDaniel Gemsa: Actor, Extra and Model - London, UK - StarNow
Photos, videos, physical attributes and credits & experience of Daniel Gemsa - Actor, Extra and Model based in London, United Kingdom
https://www.starnow.co.uk/danielgemsa1/
Ingredients and Nutrition | XP3020Ingredients and Nutrition | XP3020
PROTEIN - Protein is not required for protein itself, rather for the amino acids which make up the protein. Amino acids are required to maintain muscle, skin, coat etc. as well as provide enzymes and hormones for the correct functioning of the body. Two of the best protein sources are Egg (considered the perfect protein) and Chicken. XP3020 uses only high quality Egg and Chicken Meal as its source of quality protein.. FAT - Fat is extremely important for the dog, as dogs preferentially use fat for their energy source ie. it is the first ingredient the body uses to supply the energy needs of the dog. XP3020 uses only high quality Chicken Fat.. VITAMINS - The main function of Vitamins is as a catalyst for the body enzyme systems. They also help to resist disease and infection. Most vitamins must be provided in the diet.. MINERALS - These are only required in small amounts and must also be supplied in the diet. XP3020 uses only the best quality vitamins and minerals in suffcient ...
https://xp3020.com.au/ingredients/
Why Older Women Gain Weight More Easily Than Men - CakehealthWhy Older Women Gain Weight More Easily Than Men - Cakehealth
Many women find they pack on the pounds more easily than men do as they get older, and a new study on mice may help explain why.. After menopause, the activity of a particular enzyme involved in fat production -called Aldh1a1 - increases, the researchers said.. The enzyme is found in mice as well as people. During the study, female mice that ate a high-fat diet had more Aldh1a1 activity and made and stored more visceral fat (fat around the abdomen) than did male mice who ate a high-fat diet.. By contrast, female mice remained lean on a high-fat diet if they had been genetically engineered to lack the enzyme.. The female hormone estrogen appears to suppress Aldh1a1 activity. This might mean that younger women, who have high levels of estrogen, are protected against the enzymes undesirable effects. But after menopause, levels of estrogen decrease, causing Aldh1a1 activity to increase and making females vulnerable to weight gain.. By targeting Aldh1a1, researchers may be able to develop an obesity ...
https://cakehealth.com/3409-women-weight-gain-menopause.html
PROTEINS | Biology BoomPROTEINS | Biology Boom
ALTERNATIVE FOOD MOLECULES The catabolism of glucose is the most common metabolic pathway in cells. But animals also consume fats and proteins. These may be used to harvest energy. Fats Fats are built from long chain fatty acids and glycerol. They form triglycerides. The ...
https://biologyboom.com/tag/proteins/
Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem...Sequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem...
We have cloned the cDNA for human carboxypeptidase D (CPD), a new B-type metallocarboxypeptidase that is membrane bound and has an acidic pH optimum. The 5.8 kb of cDNA sequenced contains an open reading frame of 4131 bp encoding 1377 amino acid residues. The sequence is similar (75% identity) to duck gp180, a protein that was isolated, cloned and sequenced as a hepatitis B virus-binding protein but not characterized as a carboxypeptidase. Hydropathic analysis revealed a hydrophobic region at the N-terminus, representing the signal peptide, and one near the C-terminus that probably represents the transmembrane anchor. The most striking feature is the presence of three tandem carboxypeptidase homology domains that have sequence similarity to the regulatory B-type carboxypeptidase family, typified by carboxypeptidases M, E and N. Because of the three repeats, CPD is about three times larger (175-180 kDa) than other members of this family (approx. 50-62 kDa). Domain 2 is most closely related to ...
http://www.biochemj.org/content/327/1/81
Plus itPlus it
Treatment of cultured bovine adrenal chromaffin cells with the catecholamine transport blocker reserpine was previously shown to increase enkephalin levels several-fold. To explore the biochemical mechanism of this effect, we examined the effect of reserpine treatment on the activities of three different peptide precursor processing enzymes: carboxypeptidase E (CPE) and the prohormone convertases (PCs) PC1/3 and PC2. Reserpine treatment increased both CPE and PC activity in extracts of cultured chromaffin cells; total protein levels were unaltered for any enzyme. Further analysis showed that the increase in CPE activity was due to an elevated Vmax, with no change in the Km for substrate hydrolysis or the levels of CPE mRNA. Reserpine activation of endogenous processing enzymes was also observed in extracts prepared from PC12 cells stably expressing PC1/3 or PC2. In vitro experiments using purified enzymes showed that catecholamines inhibited CPE, PC1/3 and PC2, with dopamine quinone the most ...
http://molpharm.aspetjournals.org/content/early/2011/05/03/mol.111.072090
Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: Localization to the trans-Golgi network and recycling...Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: Localization to the trans-Golgi network and recycling...
TY - JOUR. T1 - Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells. T2 - Localization to the trans-Golgi network and recycling from the cell surface. AU - Varlamov, Oleg. AU - Fricker, Lloyd D.. PY - 1998. Y1 - 1998. N2 - Carboxypeptidase D (CPD) is a recently discovered membrane-bound metallocarboxypeptidase that has been proposed to be involved in the post-translational processing of peptides and proteins that transit the secretory pathway. In the present study, the intracellular distribution of CPD was examined in AtT-20 cells, a mouse anterior pituitary-derived corticotroph. Antisera to CPD stain the same intracellular structures as those labeled with furin and wheat germ agglutinin. This distribution is distinct from carboxypeptidase E, which is localized to the secretory vesicles in the cell processes. The perinuclear distribution of CPD is detected even when the AtT-20 cells are treated with brefeldin A for 1-30 minutes, suggesting that CPD is present in the ...
https://ohsu.pure.elsevier.com/en/publications/intracellular-trafficking-of-metallocarboxypeptidase-d-in-att-20--2
Old, Fat Mice Blamed for Virus Tr... ( Contact with humans can lead to deadl...)Old, Fat Mice Blamed for Virus Tr... ( Contact with humans can lead to deadl...)
Health,...Contact with humans can lead to deadly lung disease ...WEDNESDAY Jan. 7 (HealthDay News) -- Stemming an often fatal virus li...Known as the Sin Nombre virus the hantavirus -- meaning a viru...Its usually spread from deer mice to people when droppings are inhale...,Old,,Fat,Mice,Blamed,for,Virus,Transmission,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://www.bio-medicine.org/medicine-news-1/Old--Fat-Mice-Blamed-for-Virus-Transmission-33299-1/
Identification and Characterization of proSAAS, a Granin-Like Neuroendocrine Peptide Precursor that Inhibits Prohormone...Identification and Characterization of proSAAS, a Granin-Like Neuroendocrine Peptide Precursor that Inhibits Prohormone...
Mice (Cpefat/Cpefatand wild-type littermates) were obtained from The Jackson Laboratory (Bar Harbor, ME) and killed at 9-10 weeks of age. Brain, pituitary, and other tissues were removed and frozen on dry ice until analysis. Before freezing, a portion of the cerebral cortex was removed and used for purification of CPE to confirm the genotyping; only wild-type animals contain CPE that binds to the substrate affinity resin (Fricker et al., 1996; Varlamov et al., 1996). Brains from 10-20Cpefat/Cpefatmice or wild-type littermates were pooled and homogenized in 10 ml of boiling 0.1 m acetic acid. The homogenate was boiled for 10 min and then centrifuged at 50,000 × gfor 30 min at 4°C. The supernatant was filtered through a Centriplus-10 membrane (Amicon, Beverly, MA), and the flow through was combined with sodium acetate to give a final pH of 5.0. The material was applied to a 0.5 ml column containing immobilized anhydrotrypsin (Panvera). The column was washed with 0.5% ...
https://www.jneurosci.org/content/20/2/639?ijkey=57cef11bbfd65e1281dc540430ac1d6b72fe8c84&keytype2=tf_ipsecsha
Publications - Universität UlmPublications - Universität Ulm
Bouma HR, Dugbartey GJ, Boerema AS, Talaei F, Herwig A, Goris M, van Buiten A, Strijkstra AM , Carey HV, Henning RH, Kroese FG. (2013) Reduction of body temperature governs neutrophil retention in hibernating and nonhibernating animals by margination. J Leukoc Biol Jun 13 [Epub ahead of print]. Herwig A, de Vries EM, Bolborea M, Wilson D, Mercer JG, Ebling FJ, Morgan PJ, Barrett P (2013) Hypothalamic ventricular ependymal thyroid hormone deiodinases are an important element of circannual timing in the Siberian hamster (Phodopus sungorus). PLoS One ,doi: 10.1371/journal.pone.0062003. Helwig M, Herwig A, Barrett P, Mercer J, Klingenspor M. (2013) Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol 25:190-197. ...
https://www.uni-ulm.de/nawi/nawi-neurobio/research/prof-dr-annika-herwig/publications/
Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and...Characterization of the Mouse Aortic Carboxypeptidase-Like Protein Promoter Reveals Activity in Differentiated and...
To investigate the transcriptional regulation of the ACLP gene in VSMCs, we cloned and analyzed its promoter first in vitro and then in vivo. The single-copy mouse ACLP gene is composed of many small, closely spaced exons (Figure 1). The exon structure of the discoidin domain of ACLP is generally conserved with other discoidin domains containing proteins such as coagulation factor VIII37 and the discoidin domain tyrosine kinase receptors.38 In addition, the carboxypeptidase-like domain of mouse ACLP is similar in structure to the rat carboxypeptidase E gene.39 It is possible that ACLP could have been generated during evolution through the process of exon shuffling.40. The ACLP promoter is regulated in RASMCs via a strong positive element (−156 to −122) (Figure 4), which is bound and transactivated by Sp1 and Sp3 transcription factors (Figures 5 through 7⇑⇑). Sp1 and Sp3 are ubiquitously expressed proteins that regulate numerous genes.41 It is difficult to explain the regulation of VSMC ...
http://circres.ahajournals.org/content/90/6/728.long
Carboxypeptidase - definition of carboxypeptidase by The Free DictionaryCarboxypeptidase - definition of carboxypeptidase by The Free Dictionary
Define carboxypeptidase. carboxypeptidase synonyms, carboxypeptidase pronunciation, carboxypeptidase translation, English dictionary definition of carboxypeptidase. n. Any of several enzymes that catalyze the hydrolysis of the terminal amino acid of a polypeptide from the end that contains a free carboxyl group
http://www.thefreedictionary.com/carboxypeptidase
2010 Dietary Guidelines: Fat Made Us Fat - Fat Head2010 Dietary Guidelines: Fat Made Us Fat - Fat Head
Fat percent of total calories - 33.6. Anyone care to read those figures and then explain to me how its too much fat that sparked a rise in obesity? Were we fatter in 1977, when we ate more of the stuff? Amazing … these people can see the evidence right in front of their academic faces, then draw conclusions that have nothing to do with it. Heres an another example of explaining away results they dont like:. One longitudinal study found no association between dietary energy density and adiposity among children who were followed annually from age 2 to 18 years (Alexy, 2005). Participants in this cohort were classified by dietary pattern into clusters based on percent energy from fat, with dietary energy density lowest at 3.7 (0.4) in the low fat cluster; 4.0 (0.4) in the medium fat intake; and highest at 4.1 (0.4) in the high fat cluster. Mean BMI during the study period differed significantly, with the highest BMI in the low fat, low dietary energy density cluster, a result the investigators ...
https://www.fathead-movie.com/index.php/2010/07/08/2010-dietary-guidelines-fat-made-us-fat/?replytocom=35316
Burn fat & fat burners uncovered : weghtlossforgood.co.uk
If you want to burn fat then read about fat burners and their effect on your body fat. Simple and effective action to help you lose weight safely at weightlossforgood.co.uk.
http://www.weightlossforgood.co.uk/burn_fat.htm
Best Herbs] Burn Belly Fat Fat Burning Diet Plan Customers ExperienceBest Herbs] Burn Belly Fat Fat Burning Diet Plan Customers Experience
Because of this situation , best cardio for weight loss at the gym The ruling read It s not are there any pills with new beginnings diet On Sale surprising to know that Sheldon Siegel, are there any pills with new beginnings diet Fast Weight Loss Pill the informer, used some of the tactics used by the people Provide The Best are there any pills with new beginnings diet he worked with, and that 3 Guaranteed Ways burn belly fat he secretly recorded many conversations himself Siegel, even when he was an indispensable informer for the government, he himself are there any pills with new beginnings diet Diet Pill burn belly fat participated in weight loss pills with high blood pressure the Huluk and Colombia bombings.. We waited for the Ministry of Justice to send the tapes, and then we could listen to it word by word, looking for information related to Siegel s confession and obtained through illegal wiretapping.. Because of this, Remus will be found not guilty and the other defendants will be thrown ...
http://icecube.no/weight_lose/burn-belly-fat/
HYPERPROINSULINEMIA | MENDELIAN.COHYPERPROINSULINEMIA | MENDELIAN.CO
HYPERPROINSULINEMIA description, symptoms and related genes. Get the complete information in our medical search engine for phenotype-genotype relation
https://www.mendelian.co/diseases/hyperproinsulinemia
carboxypeptidase L Summary Report | CureHuntercarboxypeptidase L Summary Report | CureHunter
carboxypeptidase L: Cathepsin A (also named protective protein and carboxypeptidase L) stabilizes beta-galactosidase and activates neuraminidase by forming with them a high-molecular-weight lysosomal complex
http://www.curehunter.com/public/keywordSummaryC055587-carboxypeptidase-L.do
Fat Brands Inc. Announces Initiation of Quarterly Cash DividendFat Brands Inc. Announces Initiation of Quarterly Cash Dividend
LOS ANGELES--(BUSINESS WIRE)-- FAT (Fresh. Authentic. Tasty.) Brands Inc. (NASDAQ: FAT) (FAT Brands or the Company), a leading global restaurant franchising company, today announced that its Board of Directors has approved its first quarterly cash dividend. The Companys Board of Directors declared an initial quarterly dividend of $0.12 per share of common stock, payable on April 16, 2018 to stockholders of record as of the close of business on March 30, 2018. We are pleased to announce the initiation of a quarterly cash dividend, which we believe reflects the strength and stability of our business model. Our predictable cash flow generation and strong balance sheet provide the financial flexibility to continue to grow our portfolio of brands while simultaneously returning a meaningful amount of capital to our stockholders, said Andy Wiederhorn, President and CEO of FAT Brands. The Company also intends to launch a Dividend Reinvestment Plan (DRIP), under which interested stockholders may ...
https://www.streetinsider.com/Press+Releases/Fat+Brands+Inc.+Announces+Initiation+of+Quarterly+Cash+Dividend/13781037.html
Dietary Fats
Also called: Lipids, Monounsaturated fat, Polyunsaturated fat, Saturated fat Fat is a major source of energy and aids your body in absorbing vitami...
https://medications.com/dietary-fats
great value sweet cream butter saltedgreat value sweet cream butter salted
Recycling instructions and/or packaging information. Substances or products causing allergies or intolerances: Milk. You can support our work by donating to Open Food Facts and also by using the Lilo search engine.Thank you! The product is in the fats category, the points for saturated fat are replaced by the points for the saturated fat / fat ratio. Open Food Facts is made by a non-profit association, independent from the industry. Sweet Cream Butter, Salted. Amount Per Serving. Personalized health review for Great Value Whipped Butter, Salted: 70 calories, nutrition grade (D plus), problematic ingredients, and more. 4%. tbsp. Code of conduct Instagram, This product page is not complete. Great Value. There are 100 calories in a 1 tbsp serving of Great Value Butter (Salted). Substances or products causing allergies or intolerances: → The analysis is based solely on the ingredients listed and does not take into account processing methods. SWEET CREAM SALTED BUTTER SAME GREAT TASTE Customers who ...
https://olrs.org/id/f1938d-grateful-dead---smokestack-lightning
August | 2019 | ATM signaling
1 cm, respectively. The body mass index (BMI) was determined as weight/height2 (kg/m2). The biceps brachii, triceps brachii, subscapular, and suprailiac skinfold thicknesses were measured with a Harpenden caliper on the right side of the body with the subject in a standing position and are expressed as the mean of three Cilengitide manufacturer consecutive. measurements. The average of three measurements at each site was used to calculate the body density [16], percentage of body fat (%Fat), and lean body mass (LBM) [17]. All subjects were interviewed by experienced dietitians using a food frequency questionnaire Vactosertib chemical structure (FFQ), which is based on 29 food groups and 10 types of cooking, for estimating the energy and nutrient intakes of each subject during the past one to two months [18]. From FFQs, the selected mean daily dietary and nutrient intakes were calculated according to the Tables of Japanese Foodstuff Smoothened Agonist molecular weight Composition [19]. ...
https://atm-signaling.com/index.php/2019/08/
OriGene - CPXM1 (NM 019609) cDNA CloneOriGene - CPXM1 (NM 019609) cDNA Clone
CPXM1 - CPXM1 (untagged)-Human carboxypeptidase X (M14 family), member 1 (CPXM1), transcript variant 1 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/cdna/trueclone/accession/NM_019609/SC113268.aspx
OriGene - CPXM1 (NM 019609) cDNA CloneOriGene - CPXM1 (NM 019609) cDNA Clone
CPXM1 - CPXM1 (untagged)-Human carboxypeptidase X (M14 family), member 1 (CPXM1), transcript variant 1 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/human_cdna/NM_019609/SC324244.aspx
CPA1 - Carboxypeptidase A1 precursor - Homo sapiens (Human) - CPA1 gene & proteinCPA1 - Carboxypeptidase A1 precursor - Homo sapiens (Human) - CPA1 gene & protein
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
http://www.uniprot.org/uniprot/P15085
Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured) (H00005547-T01): Novus BiologicalsLysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured) (H00005547-T01): Novus Biologicals
Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured). Tested Reactivity: Hu. Validated: WB. Backed by our 100% Guarantee.
https://www.novusbio.com/products/lysosomal-pro-x-carboxypeptidase-prcp-lysate_h00005547-t01
Sequence Similarity - 1CBX: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE A AND THE BIPRODUCT ANALOG...Sequence Similarity - 1CBX: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBOXYPEPTIDASE A AND THE BIPRODUCT ANALOG...
1CBX: Crystal structure of the complex between carboxypeptidase A and the biproduct analog inhibitor L-benzylsuccinate at 2.0 A resolution.
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1CBX
Carboxypeptidase A1/CPA1 Antibody (1C12) (NBP2-01924): Novus BiologicalsCarboxypeptidase A1/CPA1 Antibody (1C12) (NBP2-01924): Novus Biologicals
Mouse Monoclonal Anti-Carboxypeptidase A1/CPA1 Antibody (1C12). Validated: WB, Flow, ICC/IF. Tested Reactivity: Human. 100% Guaranteed.
https://www.novusbio.com/products/carboxypeptidase-a1-cpa1-antibody-1c12_nbp2-01924
US Patent # 9,593,320. Proteases with modified pro regions - Patents.comUS Patent # 9,593,320. Proteases with modified pro regions - Patents.com
The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified protease
http://patents.com/us-9593320.html
Cell Bio - Biology-OnlineCell Bio - Biology-Online
thats a common mechanism in enzymes, not only in carboxypeptidase. However, the point is, there are several of these weak bonds and their sum is strong enough to stretch the peptide causing to be better to hydrolyse ...
https://www.biology-online.org/biology-forum/viewtopic.php?t=22916&p=135197&hilit=Carboxypeptidase
Plus it
In reply to Scott and colleagues,1 we found an unequivocally wide variation in reoperation after colorectal surgery. Furthermore, variation is identifiable at high surgical caseloads, suggesting that centralisation of surgical services, a policy commonly applied to reduce variation, may be ineffective. Our duty as researchers is to report variation when it clearly exceeds what would be expected by chance. The extent to … ...
http://www.bmj.com/content/343/bmj.d6614
CarboxypeptidaseCarboxypeptidase
... an alanine carboxypeptidase bradykinin is broken down among other enzymes by carboxypeptidase N D-Ala carboxypeptidase is a ... Initial studies on carboxypeptidases focused on pancreatic carboxypeptidases A1, A2, and B in the digestion of food. Most ... Carboxypeptidases act by replacing the substrate water with a carbonyl (C=O) group. The carboxypeptidase A hydrolysis reaction ... Carboxypeptidase E Carboxypeptidase A Enzyme category EC number 3.4 Thrombin-activatable fibrinolysis inhibitor aka plasma ...
https://en.wikipedia.org/wiki/Carboxypeptidase
Carboxypeptidase PCarboxypeptidase P
The term carboxypeptidase P may refer to: Lysosomal Pro-X carboxypeptidase Membrane Pro-X carboxypeptidase This set index page ...
https://en.wikipedia.org/wiki/Carboxypeptidase_P
Muramoyltetrapeptide carboxypeptidaseMuramoyltetrapeptide carboxypeptidase
... carboxypeptidase II, lysyl-D-alanine carboxypeptidase, L-lysyl-D-alanine carboxypeptidase, LD-carboxypeptidase) is an enzyme. ... Muramoyltetrapeptide+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Metz R, Henning S, Hammes WP (March 1986). "LD-carboxypeptidase activity in Escherichia coli. II. Isolation, purification and ... DasGupta H, Fan DP (July 1979). "Purification and characterization of a carboxypeptidase-transpeptidase of Bacillus megaterium ...
https://en.wikipedia.org/wiki/Muramoyltetrapeptide_carboxypeptidase
Glutamate carboxypeptidaseGlutamate carboxypeptidase
... (EC 3.4.17.11, carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, glutamyl ... Glutamate carboxypeptidase II Goldman P, Levy CC (October 1967). "Carboxypeptidase G: purification and properties". Proceedings ... Glutamate+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... Sherwood RF, Melton RG, Alwan SM, Hughes P (May 1985). "Purification and properties of carboxypeptidase G2 from Pseudomonas sp ...
https://en.wikipedia.org/wiki/Glutamate_carboxypeptidase
Carboxypeptidase B2Carboxypeptidase B2
... (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable ... Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, ... and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A ( ... "Entrez Gene: CPB2 carboxypeptidase B2 (plasma)". Bouma BN, Mosnier LO (2005). "Thrombin activatable fibrinolysis inhibitor ( ...
https://en.wikipedia.org/wiki/Carboxypeptidase_B2
Carboxypeptidase ECarboxypeptidase E
... (CPE), also known as carboxypeptidase H (CPH) and enkephalin convertase, is an enzyme that in humans is ... "Entrez Gene: CPE carboxypeptidase E". Fricker LD (1988). "Carboxypeptidase E". Annual Review of Physiology. 50: 309-21. doi: ... Biology portal Carboxypeptidase Carboxypeptidase A GRCh38: Ensembl release 89: ENSG00000109472 - Ensembl, May 2017 GRCm38: ... fills in for carboxypeptidase E in this organism. In humans, CPE is encoded by the CPE gene. Carboxypeptidase E functions in ...
https://en.wikipedia.org/wiki/Carboxypeptidase_E
Dipeptidyl carboxypeptidaseDipeptidyl carboxypeptidase
... may refer to: Angiotensin-converting enzyme (ACE) Peptidyl-dipeptidase Dcp This set index page ...
https://en.wikipedia.org/wiki/Dipeptidyl_carboxypeptidase
Carboxypeptidase GCarboxypeptidase G
... may refer to: Glutamate carboxypeptidase, an enzyme Gamma-glutamyl hydrolase, an enzyme This set index page ...
https://en.wikipedia.org/wiki/Carboxypeptidase_G
Muramoylpentapeptide carboxypeptidaseMuramoylpentapeptide carboxypeptidase
D-alanine carboxypeptidase I, DD-carboxypeptidase, D-alanine carboxypeptidase, D-alanyl-D-alanine carboxypeptidase, D-alanine-D ... carboxypeptidase, carboxypeptidase D-alanyl-D-alanine, carboxypeptidase I, UDP-N-acetylmuramoyl-tetrapeptidyl-D-alanine alanine ... Muramoylpentapeptide+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Purification and properties of two D-alanine carboxypeptidases from Escherichia coli". The Journal of Biological Chemistry. 243 ...
https://en.wikipedia.org/wiki/Muramoylpentapeptide_carboxypeptidase
Carboxypeptidase UCarboxypeptidase U
... (EC 3.4.17.20, arginine carboxypeptidase, carboxypeptidase R, plasma carboxypeptidase B, thrombin- ... Wang W, Hendriks DF, Scharpé SS (June 1994). "Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen ... plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U. Carboxypeptidase Eaton DL, ... Carboxypeptidase+U at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ...
https://en.wikipedia.org/wiki/Carboxypeptidase_U
Carboxypeptidase CCarboxypeptidase C
... (EC 3.4.16.5, carboxypeptidase Y, serine carboxypeptidase I, cathepsin A, lysosomal protective protein, ... Carboxypeptidase+C at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.16). ... Cathepsin A Breddam, K. (1986). "Serine carboxypeptidases. A review". Carlsberg Res. Commun. 51: 83-128. doi:10.1007/bf02907561 ... deamidase, lysosomal carboxypeptidase A, phaseolin) is an enzyme. This enzyme catalyses the following chemical reaction Release ...
https://en.wikipedia.org/wiki/Carboxypeptidase_C
Carboxypeptidase ACarboxypeptidase A
... inhibitor Carboxypeptidase B Carboxypeptidase Carboxypeptidase E Christianson DW, Lipscomb WN (February 1989 ... This property of carboxypeptidase A led to the first clause of Daniel E. Koshland, Jr.'s "induced fit" hypothesis. The S1 sub- ... Carboxypeptidase A (CPA) contains a zinc (Zn2+) metal center in a tetrahedral geometry with amino acid residues in close ... Carboxypeptidase A usually refers to the pancreatic exopeptidase that hydrolyzes peptide bonds of C-terminal residues with ...
https://en.wikipedia.org/wiki/Carboxypeptidase_A
Carboxypeptidase A6Carboxypeptidase A6
Carboxypeptidase A inhibitor Carboxypeptidase GRCh38: Ensembl release 89: ENSG00000165078 - Ensembl, May 2017 GRCm38: Ensembl ... Carboxypeptidase A6 (CPA6) is a metallocarboxypeptidase enzyme that in humans is encoded by the CPA6 gene. It is highly ... "Entrez Gene: Carboxypeptidase A6". Retrieved 2011-11-25. Lyons PJ, Callaway MB, Fricker LD (March 2008). "Characterization of ... The protein encoded by this gene belongs to the family of carboxypeptidases, which catalyze the release of C-terminal amino ...
https://en.wikipedia.org/wiki/Carboxypeptidase_A6
Arginine carboxypeptidaseArginine carboxypeptidase
... may refer to: Lysine carboxypeptidase, an enzyme Carboxypeptidase U, an enzyme This set index page ...
https://en.wikipedia.org/wiki/Arginine_carboxypeptidase
Carboxypeptidase MCarboxypeptidase M
... (EC 3.4.17.12, CPM) is an enzyme. This enzyme catalyses the following chemical reaction Cleavage of C- ... Carboxypeptidase+M at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... Deddish PA, Skidgel RA, Erdös EG (July 1989). "Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. ... Similarity to carboxypeptidase H (enkephalin convertase)". The Biochemical Journal. 261 (1): 289-91. PMC 1138816. PMID 2775217 ...
https://en.wikipedia.org/wiki/Carboxypeptidase_M
Carboxypeptidase A2Carboxypeptidase A2
"Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2 ... Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene. Three different forms of human pancreatic ... "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)". Pascual R, Burgos FJ, Salva M, et al. (1989). "Purification and properties ... Human Carboxypeptidase A2) at the PDBe-KB. Portal: Biology v t e (Genes on human chromosome 7, EC 3.4.17, All stub articles, ...
https://en.wikipedia.org/wiki/Carboxypeptidase_A2
Carboxypeptidase TCarboxypeptidase T
... intracellular carboxypeptidase of Thermoactinomycetes--a distant analog of animal carboxypeptidase]". Biokhimiia. 49 (2): 292- ... Carboxypeptidase T (EC 3.4.17.18, CPT) is an enzyme. This enzyme catalyses the following chemical reaction: Releases a C- ... Carboxypeptidase+T at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... Osterman AL, Stepanov VM, Rudenskaia GN, Khodova OM, Tsaplina IA (February 1984). "[Carboxypeptidase T-- ...
https://en.wikipedia.org/wiki/Carboxypeptidase_T
Carboxypeptidase A1Carboxypeptidase A1
... is an enzyme that in humans is encoded by the CPA1 gene. Three different forms of human pancreatic ... "Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic)". Catasús L, Villegas V, Pascual R, et al. (1992). "cDNA cloning and ... Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition. GRCh38: Ensembl release 89: ... Stewart EA, Craik CS, Hake L, Bowcock AM (1990). "Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter". Am. ...
https://en.wikipedia.org/wiki/Carboxypeptidase_A1
Alanine carboxypeptidaseAlanine carboxypeptidase
Alanine+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... Alanine carboxypeptidase (EC 3.4.17.6, N-benzoyl-L-alanine-amidohydrolase) is an enzyme. This enzyme catalyses the following ...
https://en.wikipedia.org/wiki/Alanine_carboxypeptidase
Zinc carboxypeptidaseZinc carboxypeptidase
The carboxypeptidase A family can be divided into two subfamilies: carboxypeptidase H (regulatory) and carboxypeptidase A ( ... "Primary structure of carboxypeptidase T: delineation of functionally relevant features in Zn-carboxypeptidase family". J. ... Structural studies of carboxypeptidases A and B reveal the propeptide to exist as a globular domain, followed by an extended ... Members of the carboxypeptidase A family are synthesised as inactive molecules with propeptides that must be cleaved to ...
https://en.wikipedia.org/wiki/Zinc_carboxypeptidase
Carboxypeptidase TaqCarboxypeptidase Taq
"Purification and characterization of a thermostable carboxypeptidase (carboxypeptidase Taq) from Thermus aquaticus YT-1". ... Carboxypeptidase Taq (EC 3.4.17.19) is an enzyme. This enzyme catalyses the following chemical reaction Release of a C-terminal ... Carboxypeptidase+Taq at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... Lee SH, Taguchi H, Yoshimura E, Minagawa E, Kaminogawa S, Ohta T, Matsuzawa H (August 1994). "Carboxypeptidase Taq, a ...
https://en.wikipedia.org/wiki/Carboxypeptidase_Taq
Gly-X carboxypeptidaseGly-X carboxypeptidase
Gly-Xaa carboxypeptidase (EC 3.4.17.4, glycine carboxypeptidase, carboxypeptidase a, carboxypeptidase S, peptidase alpha, yeast ... Gly-Xaa+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4.17). ... carboxypeptidase) is an enzyme. This enzyme catalyses the following chemical reaction Release of a C-terminal amino acid from a ...
https://en.wikipedia.org/wiki/Gly-X_carboxypeptidase
Glutamate carboxypeptidase IIGlutamate carboxypeptidase II
... (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase ... All of which refer to the same protein glutamate carboxypeptidase II. GCPII is mainly expressed in four tissues of the body, ... and carboxypeptidase activity based on the parent tissue. The hydrolysis of NAAG by GCPII obeys Michaelis-Menten kinetics. ...
https://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II
Carboxypeptidase A inhibitorCarboxypeptidase A inhibitor
The structure of the complex between bovine carboxypeptidase A and the 39-amino-acid carboxypeptidase A inhibitor from potatoes ... Hass GM, Nau H, Biemann K, Grahn DT, Ericsson LH, Neurath H (March 1975). "The amino acid sequence of a carboxypeptidase ... In molecular biology, the carboxypeptidase A inhibitor family is a family of proteins which is represented by the well- ... Rees DC, Lipscomb WN (August 1980). "Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution". Proc ...
https://en.wikipedia.org/wiki/Carboxypeptidase_A_inhibitor
Potato carboxypeptidase inhibitorPotato carboxypeptidase inhibitor
PCI also inhibits carboxypeptidase R without affecting the activity of carboxypeptidase N in the circulation and have therefore ... May 1998). "Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor ... Potato carboxypeptidase inhibitor (PCI) is a naturally occurring protease inhibitor peptide in potatoes that can form complexes ... a Redlitz A, Tan AK, Eaton DL, Plow EF (November 1995). "Plasma carboxypeptidases as regulators of the plasminogen system". J. ...
https://en.wikipedia.org/wiki/Potato_carboxypeptidase_inhibitor
Tubulinyl-Tyr carboxypeptidaseTubulinyl-Tyr carboxypeptidase
... carboxypeptidase-tubulin, soluble carboxypeptidase, tubulin-tyrosine carboxypeptidase, tubulin carboxypeptidase, ... tyrosinotubulin carboxypeptidase, tyrosyltubulin carboxypeptidase, TTCPase, brain I carboxypeptidase) is an enzyme. This enzyme ... Tubulinyl-Tyr+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.4. ... Kumar N, Flavin M (July 1981). "Preferential action of a brain detyrosinolating carboxypeptidase on polymerized tubulin". The ...
https://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase
Membrane Pro-X carboxypeptidaseMembrane Pro-X carboxypeptidase
Membrane Pro-Xaa carboxypeptidase (EC 3.4.17.16, carboxypeptidase P, microsomal carboxypeptidase) is an enzyme. This enzyme ... Membrane+Pro-Xaa+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC ... Isolation of a microsomal carboxypeptidase from swine kidney". European Journal of Biochemistry. 17 (2): 372-7. doi:10.1111/j. ... Purification and properties of carboxypeptidase P from pig kidneys". The Biochemical Journal. 229 (1): 251-7. doi:10.1042/ ...
https://en.wikipedia.org/wiki/Membrane_Pro-X_carboxypeptidase
Lysosomal Pro-X carboxypeptidaseLysosomal Pro-X carboxypeptidase
... aminoacylproline carboxypeptidase, prolyl carboxypeptidase, carboxypeptidase P, proline-specific carboxypeptidase P, PCP) is an ... Lysosomal Pro-Xaa carboxypeptidase (EC 3.4.16.2, angiotensinase C, lysosomal carboxypeptidase C, peptidylprolylamino acid ... Lysosomal+Pro-Xaa+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) human ...
https://en.wikipedia.org/wiki/Lysosomal_Pro-X_carboxypeptidase
Zinc D-Ala-D-Ala carboxypeptidaseZinc D-Ala-D-Ala carboxypeptidase
D-alanyl-D-alanine-cleaving carboxypeptidase, DD-carboxypeptidase, G enzyme, DD-carboxypeptidase-transpeptidase) is an enzyme. ... Zinc+D-Ala-D-Ala+carboxypeptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC ... Zinc D-Ala-D-Ala carboxypeptidase (EC 3.4.17.14, Zn2+ G peptidase, D-alanyl-D-alanine hydrolase, ... "The complete amino acid sequence of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of streptomyces albus G". ...
https://en.wikipedia.org/wiki/Zinc_D-Ala-D-Ala_carboxypeptidase
Carboxypeptidase x, m14 family member 2Carboxypeptidase x, m14 family member 2
... is a protein that in humans is encoded by the CPXM2 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: Carboxypeptidase X, M14 family member 2". Retrieved 2018-06-01. Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, ...
https://en.wikipedia.org/wiki/Carboxypeptidase_x,_m14_family_member_2
Cpvl MGI Mouse Gene Detail - MGI:1918537 - carboxypeptidase, vitellogenic-likeCpvl MGI Mouse Gene Detail - MGI:1918537 - carboxypeptidase, vitellogenic-like
View mouse Cpvl Chr6:53850264-53955656 with: phenotypes, sequences, polymorphisms, proteins, references, function
http://www.informatics.jax.org/marker/MGI:1918537
CPM (carboxypeptidase M)CPM (carboxypeptidase M)
Carboxypeptidase M in apoptosis, adipogenesis and cancer.. Denis CJ et al. 23294303. 2013. The potential of carboxypeptidase M ... Carboxypeptidase M in Madin-Darby canine kidney cells. Evidence that carboxypeptidase M has a phosphatidylinositol glycan ... Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, ... CPM (carboxypeptidase M). 2013-07-01 Anne-Marie Lambeir Affiliation Laboratory of Medical Biochemistry, University of Antwerp, ...
https://atlasgeneticsoncology.org/gene/51348/cpm-
RCSB PDB - 1AC5: CRYSTAL STRUCTURE OF KEX1(DELTA)P, A PROHORMONE-PROCESSING CARBOXYPEPTIDASE FROM SACCHAROMYCES CEREVISIAERCSB PDB - 1AC5: CRYSTAL STRUCTURE OF KEX1(DELTA)P, A PROHORMONE-PROCESSING CARBOXYPEPTIDASE FROM SACCHAROMYCES CEREVISIAE
In contrast to yeast serine carboxypeptidase (CPD-Y) and wheat serine carboxypeptidase II (CPDW-II), Kex1p displays a very ... In contrast to yeast serine carboxypeptidase (CPD-Y) and wheat serine carboxypeptidase II (CPDW-II), Kex1p displays a very ... CRYSTAL STRUCTURE OF KEX1(DELTA)P, A PROHORMONE-PROCESSING CARBOXYPEPTIDASE FROM SACCHAROMYCES CEREVISIAE. *PDB DOI: 10.2210/ ... Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae.. Shilton, B.H., Thomas ...
https://www.rcsb.org/structure/1ac5
ENZYME - 3.4.17.24 tubulin-glutamate carboxypeptidaseENZYME - 3.4.17.24 tubulin-glutamate carboxypeptidase
In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17 ...
https://enzyme.expasy.org/EC/3.4.17.24
Porcine Carboxypeptidase B Purified Enzyme - Innovative ResearchPorcine Carboxypeptidase B Purified Enzyme - Innovative Research
Chymotrypsin and trypsin 0.02%. Carboxypeptidase B is an enzyme involved in the digestion of food. A protease enzyme, ... Porcine Carboxypeptidase B Purified Enzyme from Innovative Research has been chromatographically purified. This is a frozen ... A protease enzyme, Carboxypeptidase B hydrolyzes peptide bonds at the C-terminal end of a protein or peptide. Carboxypeptidases ... Product Inquiry for Porcine Carboxypeptidase B Purified Enzyme. Name. Email. Phone Number. Message. ...
https://www.innov-research.com/products/porcine-carboxypeptidase-b-purified-enzyme
Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity<...
Carboxypeptidase E (CPE) is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. One of ... N2 - Carboxypeptidase E (CPE) is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. One ... AB - Carboxypeptidase E (CPE) is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. One ... Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity. Piero Nicolao, Massimo Carella, Bruno ...
https://moh-it.pure.elsevier.com/en/publications/missense-polymorphism-in-the-human-carboxypeptidase-e-gene-alters
Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in...
Takatsu, Y., Fujita, Y., Tsukamoto, T., Slusher, B. S., & Hashimoto, K. (2011). Orally active glutamate carboxypeptidase II ... Takatsu Y, Fujita Y, Tsukamoto T, Slusher BS, Hashimoto K. Orally active glutamate carboxypeptidase II inhibitor 2-MPPA ... N2 - Glutamate carboxypeptidase II (GCP II) is a glial enzyme responsible for the hydrolysis of N-acetylaspartylglutamate (NAAG ... AB - Glutamate carboxypeptidase II (GCP II) is a glial enzyme responsible for the hydrolysis of N-acetylaspartylglutamate (NAAG ...
https://jhu.pure.elsevier.com/en/publications/orally-active-glutamate-carboxypeptidase-ii-inhibitor-2-mppa-atte-4
Carboxypeptidase M/CPM蛋白, Mouse (422a.a, HEK293, His) | MCECarboxypeptidase M/CPM蛋白, Mouse (422a.a, HEK293, His) | MCE
MCE提供Carboxypeptidase M/CPM蛋白, Mouse (422a.a, HEK293, His)，体外功能蛋白活性验证，出色的批间稳定性， ... Carboxypeptidase M/CPM Protein, Mouse (422a.a, HEK293, His) 相关产品:. * Carboxypeptidase M/CPM Protein, Mouse (406a.a, HEK293, His ... Carboxypeptidase M/CPM 蛋白, Mouse (422a.a, HEK293, His) 目录号: HY-P73494 Data Sheet 产品使用指南 ... Carboxypeptidase M/CPM Protein, Mouse
https://www.medchemexpress.cn/recombinant-proteins/carboxypeptidase-m-protein-mouse-422a-a-hek293-his.html
Muramoylpentapeptide Carboxypeptidase | Profiles RNS
"Muramoylpentapeptide Carboxypeptidase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... This graph shows the total number of publications written about "Muramoylpentapeptide Carboxypeptidase" by people in this ... Below are the most recent publications written about "Muramoylpentapeptide Carboxypeptidase" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Muramoylpentapeptide Carboxypeptidase". ...
https://profiles.rush.edu/display/7732
Toxins | Free Full-Text | Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium ...Toxins | Free Full-Text | Morphologic, Phylogenetic and Chemical Characterization of a Brackish Colonial Picocyanobacterium ...
The fractionated extracts showed significant activity against carboxypeptidase A and trypsin. Inhibition of these important ... The carboxypeptidase A inhibition assays were modified from described methods [62,63]. Carboxypeptidase A from bovine pancreas ... Hass, G.M.; Ager, S.P.; Le Tourneau, D.; Derr-Makus, J.E. Specificity of the carboxypeptidase inhibitor from potatoes. Plant ... APs are the only known cyanobacteria peptide inhibitors of the pancreatic metalloexopeptidase carboxypeptidase A [5,37,39,40]. ...
https://www.mdpi.com/2072-6651/8/4/108
Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking<...Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking<...
Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking. Elena Kalinina, Oleg Varlamov ... Analysis of the carboxypeptidase D cytoplasmic domain: Implications in intracellular trafficking. Journal of cellular ... Analysis of the carboxypeptidase D cytoplasmic domain : Implications in intracellular trafficking. / Kalinina, Elena; Varlamov ... Kalinina, E., Varlamov, O., & Fricker, L. D. (2002). Analysis of the carboxypeptidase D cytoplasmic domain: Implications in ...
https://ohsu.pure.elsevier.com/en/publications/analysis-of-the-carboxypeptidase-d-cytoplasmic-domain-implication-2
Glutamate Carboxypeptidase II</span><span class=...Glutamate Carboxypeptidase II</span><span class=...
Glutamate carboxypeptidase II (GCPII) is a 94 kD class II membrane bound zinc metalloenzyme which catalyzes the hydrolysis of ... Barinka C, Rojas C, Slusher BS, Pomper M. "Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and ... Johns Hopkins Drug Discovery - Project - Glutamate Carboxypeptidase II. 53 page-template,page-template-full_width,page-template ... "Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic ...
https://drugdiscovery.jhu.edu/our-projects/gcp-ii/
Zn-dependent arginine carboxypeptidase-like family domain assignmentsZn-dependent arginine carboxypeptidase-like family domain assignments
Zn-dependent arginine carboxypeptidase-like family domain assignments . Domain assignment details for each protein include ... Zn-dependent arginine carboxypeptidase-like family domain assignments No domain assignments for these genomes.. Add assignments ... View all assignments containing a Zn-dependent arginine carboxypeptidase-like domain in each group of genomes. ...
https://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/genome.cgi?sf=159340
Zinc in PDB 4gm5: Carboxypeptidase T with Sulphamoil Arginine
Enzymatic activity of Carboxypeptidase T with Sulphamoil Arginine. All present enzymatic activity of Carboxypeptidase T with ... S.A.Kuznetsov, V.I.Timofeev, V.K.Akparov, I.P.Kuranova. Carboxypeptidase T with Sulphamoil Arginine To Be Published. ... The structure of Carboxypeptidase T with Sulphamoil Arginine, PDB code: 4gm5 was solved by S.A.Kuznetsov, V.I.Timofeev, V.K. ... The structure of Carboxypeptidase T with Sulphamoil Arginine also contains other interesting chemical elements:. Calcium. (Ca) ...
http://zinc.atomistry.com/pdb4gm5.html
Carboxypeptidase B, Sequencing Grade Carboxypeptidase B, For Mass SpectrometryCarboxypeptidase B, Sequencing Grade Carboxypeptidase B, For Mass Spectrometry
Sequencing Grade Carboxypeptidase B, For Mass Spectrometry from China, Chinas leading Recombinant Carboxypeptidase B product ... Producing high quality Carboxypeptidase B, Sequencing Grade Carboxypeptidase B, For Mass Spectrometry products. ... market, With strict quality control Recombinant Carboxypeptidase B factories, ... Recombinant Carboxypeptidase B Carboxypeptidase Enzyme, Animal Origin Free, Carboxypeptidase B, Proteomics Grade ...
https://www.recombinanttrypsin.com/sale-7580658-carboxypeptidase-b-sequencing-grade-carboxypeptidase-b-for-mass-spectrometry.html
Carboxypeptidases<...Carboxypeptidases<...
title = "Carboxypeptidases",. abstract = "Carboxypeptidases are involved in a wide range of physiological processes, ranging ... Carboxypeptidases. / Fricker, Lloyd.. xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., 2007. p. 1-4.. Research ... N2 - Carboxypeptidases are involved in a wide range of physiological processes, ranging from the digestion of food to the ... AB - Carboxypeptidases are involved in a wide range of physiological processes, ranging from the digestion of food to the ...
https://einstein.pure.elsevier.com/en/publications/carboxypeptidases-2
Investigation of the cellular mechanisms underlying the carboxypeptidase E mutationInvestigation of the cellular mechanisms underlying the carboxypeptidase E mutation
F. Kasikci, C. X. Niamh, T. Yanık, and P. Y. Loh, "Investigation of the cellular mechanisms underlying the carboxypeptidase E ...
https://open.metu.edu.tr/handle/11511/55719
Recombinant Human Carboxypeptidase B2/CPB2 (C-6His) | Bon Opus BiosciencesRecombinant Human Carboxypeptidase B2/CPB2 (C-6His) | Bon Opus Biosciences
Recombinant Human Carboxypeptidase B2 is produced by our Mammalian expression system and the target gene encoding Phe23-Val423 ...
https://www.bonopusbio.com/product-page/novoprotein-recombinant-human-carboxypeptidase-b2-cpb2-c-6his
IMSEAR at SEARO: Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas.
The two forms of buffalo carboxypeptidase A lose a part of their activity when incubated at their optimal temperature. Both the ... Sud Mir, Dua R D. Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas. Journal of Biosciences. ... On this basis, a new mechanism for the hydrolysis of acyldipeptides by carboxypeptidase A has been proposed. ... Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas. ...
https://imsear.searo.who.int/handle/123456789/160481
Kounis SyndromeKounis Syndrome
How much do you know about Kounis syndrome-- the concurrence of acute coronary events with allergic or hypersensitivity reactions?
https://www.medscape.com/viewarticle/732843
Characterization of an islet carboxypeptidase b involved in prohormone processing<...
N2 - An islet carboxypeptidase B-like enzyme (CP B) has been identified and characterized in secretory granules of anglerfish ... AB - An islet carboxypeptidase B-like enzyme (CP B) has been identified and characterized in secretory granules of anglerfish ... An islet carboxypeptidase B-like enzyme (CP B) has been identified and characterized in secretory granules of anglerfish islets ... abstract = "An islet carboxypeptidase B-like enzyme (CP B) has been identified and characterized in secretory granules of ...
https://creighton.pure.elsevier.com/en/publications/characterization-of-an-islet-carboxypeptidase-b-involved-in-proho
Mouse Carboxypeptidase B1 / CPB1 ELISA Pair Set (Artikelnr: SEK50386) von Sino BiologicalMouse Carboxypeptidase B1 / CPB1 ELISA Pair Set (Artikelnr: SEK50386) von Sino Biological
Mouse Carboxypeptidase B1 / CPB1 ELISA Pair Set detection - quantification SEK50386 Sino Biological Pack: ... Mouse Carboxypeptidase B1 / CPB1 ELISA Pair Set. Brand. Sino Biological. short description. The Mouse Carboxypeptidase B1 / ... The minimum detectable dose of Mouse Carboxypeptidase B1 / CPB1 was determined to be approximately 12.5 pg/ml. This is defined ... The minimum detectable dose of Mouse Carboxypeptidase B1 / CPB1 was determined to be approximately 12.5 pg/ml. This is defined ...
https://elisa-kits.de/de/mouse-carboxypeptidase-b1-cpb1-elisa-pair-set.html
Calcium in PDB 2c6p: Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion
Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion ... The structure of Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion also contains other ... A full contact list of Calcium with other atoms in the Ca binding site number 1 of Membrane-Bound Glutamate Carboxypeptidase II ... Calcium binding site 1 out of 1 in the Membrane-Bound Glutamate Carboxypeptidase II (Gcpii) in Complex with Phosphate Anion. ...
http://calcium.atomistry.com/pdb2c6p.html
Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and...Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and...
Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and ... Glutamate Carboxypeptidase IIBiological Activity Inhibitionglutamate carboxypeptidase IIbinding modevivo pharmacokinetics ... Inhibition of glutamate carboxypeptidase II (GCPII) is effective in preclinical models of neurological disorders associated ... Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and ...
https://acs.figshare.com/articles/journal_contribution/Unprecedented_Binding_Mode_of_Hydroxamate_Based_Inhibitors_of_Glutamate_Carboxypeptidase_II_Structural_Characterization_and_Biological_Activity/3199222/1
PDB 6SN6 | Chain CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-GLUTAMIC ACID | 6SN6 A | 3D Structure | canSARSPDB 6SN6 | Chain CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-GLUTAMIC ACID | 6SN6 A | 3D Structure | canSARS
CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-GLUTAMIC ACID - 6SN6 , canSARS ...
https://corona-1.cansar.icr.ac.uk/structure/6SN6/3d/6SN6_A
Table of Contents page: Journal of Biological ChemistryTable of Contents page: Journal of Biological Chemistry
Structure and Function of REP34 Implicates Carboxypeptidase Activity in Francisella tularensis Host Cell Invasion*. *Geoffrey K ...
https://www.jbc.org/issue/S0021-9258
Table 2 - Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections -...
C51 family D-Ala-D-Gly carboxypeptidase. Cell wall hydrolase. 85. (24). ...
https://wwwnc.cdc.gov/eid/article/27/3/20-0852-t2
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. |...A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. |...
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. ...
https://ir.sinica.edu.tw/handle/201000000A/9276
PDF] Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of...PDF] Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of...
Inhibition of glutamate carboxypeptidase II (GCP II) reduces glutamate release generated from N-acetyl-aspartyl-glutamate in ... Mice lacking glutamate carboxypeptidase II are protected from peripheral neuropathy and ischemic brain injury. *D. Bacich, K. ... Inhibition of glutamate carboxypeptidase II (GCP II) reduces glutamate release generated from N… Expand. ... The Orally Active Glutamate Carboxypeptidase II Inhibitor E2072 Exhibits Sustained Nerve Exposure and Attenuates Peripheral ...
https://www.semanticscholar.org/paper/Effect-of-2-
1,10-Phenanthroline - Wikipedia1,10-Phenanthroline - Wikipedia
1,10-Phenanthroline is an inhibitor of metallopeptidases, with one of the first observed instances reported in carboxypeptidase ... Felber, Jean-Pierre; Coombs, Thomas L.; Vallee, Bert L. (1962). "The mechanism of inhibition of carboxypeptidase A by 1,10- ...
https://en.wikipedia.org/wiki/Phenanthroline
ENZYMEGCPIISerine carboxypeptidaseArginineProteinHydrolaseProteinsHydrolysisPeptidasesPeptidesReceptorDescriptorProstate CancerInsulinApproximatelyStructureActivityBasicProductMajorSpecificPresentEnzymePancreaticGlutamate carboxypeptidaseProteinsForm a unique fingerprintArginine carboxypeptidasePeptidesEndopeptidasePutativeRecombinantProlyl carboxypeptidaseChymotrypsinCleavesResiduesAntibodyABSTRACTLysineExopeptidasesCPG2ExopeptidaseGlucarpidaseReceptorExtracellularPlasmaHydrolyzesSterile
ENZYME8
  • Porcine Carboxypeptidase B Purified Enzyme from Innovative Research has been chromatographically purified. (innov-research.com)
  • Carboxypeptidase B is an enzyme involved in the digestion of food. (innov-research.com)
  • A protease enzyme, Carboxypeptidase B hydrolyzes peptide bonds at the C-terminal end of a protein or peptide. (innov-research.com)
  • Glutamate carboxypeptidase II (GCP II) is a glial enzyme responsible for the hydrolysis of N-acetylaspartylglutamate (NAAG) into glutamate and N-acetylaspartate (NAA). (elsevier.com)
  • An islet carboxypeptidase B-like enzyme (CP B) has been identified and characterized in secretory granules of anglerfish islets. (elsevier.com)
  • 1,10-Phenanthroline is an inhibitor of metallopeptidases , with one of the first observed instances reported in carboxypeptidase A. [13] Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. (wikipedia.org)
  • A study was undertaken to determine the effect of inhibition of endogenous carboxypeptidase, neutral endopeptidase, or angiotensin converting enzyme on airway reactivity to the peptide hormone bradykinin. (cdc.gov)
  • The authors conclude that airway reactivity to bradykinin is regulated by lung cell membrane carboxypeptidase, endopeptidase, and angiotensin converting enzyme, and that the influence of carboxypeptidase increases when the activities of neutral endopeptidase and angiotensin converting enzyme are reduced. (cdc.gov)
GCPII4
  • Glutamate carboxypeptidase II (GCPII) is a 94 kD class II membrane bound zinc metalloenzyme which catalyzes the hydrolysis of the abundant neuropeptide N-acetylaspartylglutamate (NAAG) to glutamate. (jhu.edu)
  • Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA). (jhu.edu)
  • Inhibition of glutamate carboxypeptidase II (GCPII) is effective in preclinical models of neurological disorders associated with excessive activation of glutamatergic systems. (figshare.com)
  • Association of glutamate carboxypeptidase II (GCPII) haplotypes with breast and prostate cancer risk. (cdc.gov)
Serine carboxypeptidase1
  • Kex1p is a prohormone-processing serine carboxypeptidase found in Saccharomyces cerevisiae. (rcsb.org)
Arginine4
  • The binding sites of Zinc atom in the Carboxypeptidase T with Sulphamoil Arginine (pdb code 4gm5 ). (atomistry.com)
  • Carboxypeptidase T with Sulphamoil Arginine To Be Published . (atomistry.com)
  • Carboxypeptidase B catalyzes hydrolysis of the basic amino acids lysine, arginine and histidine from the C-terminal end of polypeptides. (recombinanttrypsin.com)
  • Carboxypeptidase B is competitively inhibited by arginine and lysine. (recombinanttrypsin.com)
Protein2
  • The protein, known as CPE-delta N, is a form of carboxypeptidase E (CPE). (nih.gov)
  • Penicillin-binding protein 5, D-alanyl-D-alanine carboxypeptidase [Interproscan]. (ntu.edu.sg)
Hydrolase2
  • The spherical carboxypeptidase domain (first 295 amino acids) is arranged in a typical α/β hydrolase fold and carries the catalytic site. (atlasgeneticsoncology.org)
  • Comparison of Substrate Specificity of Escherichia Coli p -Aminobenzoyl-Glutamate Hydrolase with Pseudomonas Carboxypeptidase G. (bvsalud.org)
Proteins1
  • Carboxypeptidases help proteins to mature and are involved in regulating biological processes, and can be found helping with various functions like blood clotting, producing growth factor, wound healing, and more. (innov-research.com)
Hydrolysis1
  • On this basis, a new mechanism for the hydrolysis of acyldipeptides by carboxypeptidase A has been proposed. (who.int)
Peptidases1
  • Lung peptidases, including carboxypeptidase, modulate airway reactivity to intravenous bradykinin. (cdc.gov)
Peptides1
  • Carboxypeptidases are involved in a wide range of physiological processes, ranging from the digestion of food to the biosynthesis of peptides that function in cell-cell signaling. (elsevier.com)
Receptor1
  • A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. (sinica.edu.tw)
Descriptor1
  • Muramoylpentapeptide Carboxypeptidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Prostate Cancer2
  • Barinka C, Rojas C, Slusher BS, Pomper M. "Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer. (jhu.edu)
  • Structure of Glutamate Carboxypeptidase II, A Drug Target in Neuronal Damage and Prostate Cancer. (atomistry.com)
Insulin1
  • Carboxypeptidase E (CPE) is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. (elsevier.com)
Approximately1
  • The minimum detectable dose of Mouse Carboxypeptidase B1 / CPB1 was determined to be approximately 12.5 pg/ml. (elisa-kits.de)
Structure2
  • The CPM structure consists of two domains, the classical carboxypeptidase domain and the C-terminal domain. (atlasgeneticsoncology.org)
  • The catalytic carboxypeptidase domain is shown on top and the cup-shaped C-terminal domain on bottom of the structure. (atlasgeneticsoncology.org)
Activity1
  • The two forms of buffalo carboxypeptidase A lose a part of their activity when incubated at their optimal temperature. (who.int)
Basic1
Product2
  • IMSEAR at SEARO: Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas. (who.int)
  • Sud Mir, Dua R D. Product stabilization of the two forms of carboxypeptidase A from buffalo pancreas. (who.int)
Major1
  • This graph shows the total number of publications written about "Muramoylpentapeptide Carboxypeptidase" by people in this website by year, and whether "Muramoylpentapeptide Carboxypeptidase" was a major or minor topic of these publications. (rush.edu)
Specific1
  • It utilizes a monoclonal antibody specific for Carboxypeptidase B1 / CPB1 coated on a 96-well plate. (elisa-kits.de)
Present2
  • Standards and samples are added to the wells, and any Carboxypeptidase B1 / CPB1 present binds to the immobilized antibody. (elisa-kits.de)
  • The wells are again washed and TMB substrate solution is loaded, which produces color in proportion to the amount of Carboxypeptidase B1 / CPB1 present in the sample. (elisa-kits.de)
Enzyme11
  • The crystal structures of carboxypeptidase T (CpT) complexes with phenylalanine and arginine substrate analogs - benzylsuccinic acid and (2-guanidinoethylmercapto)succinic acid - were determined by the molecular replacement method at resolutions of 1.57 Å and 1.62 Å to clarify the broad substrate specificity profile of the enzyme. (sigmaaldrich.com)
  • This study examined the effect of 2-(phosphonomethyl)-pentanedioic acid (2-PMPA), a potent and selective inhibitor of glutamate carboxypeptidase II (GCP II), an enzyme releasing glutamate and N-acetyl-aspartate from synaptical terminals, on the electroconvulsive threshold in mice. (unboundmedicine.com)
  • Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry. (nih.gov)
  • galactosidase and carboxypeptidase A. The purified enzyme liberated sialic acid residues from sialooligosaccaharides (a-2,3- was preferred than a-2,6-sialyllactose), sialoglycoprotein and ganglioside such as GM3 and GD1a, however, the GM2 and GD1b are not suitable substrates for the sialidase as were also shown for BSM and guinea pig serum. (unmul.ac.id)
  • Pancreatic or tissue Carboxypeptidase B (CPB), a key enzyme involved in insulin conversion and highly specific for excising C-terminal Lys and Arg residues from peptides and proteins, was expressed at high level and purified from a recombinant Pichia pastoris strain. (recombinanttrypsin.com)
  • There is no trace of other enzyme (such as carboxypeptidase A and chymotrypsin) activity. (recombinanttrypsin.com)
  • The enzyme is also known as glutamate carboxypeptidase II (GCPII), folate hydrolase 1, folypoly-gamma-glutamate carboxypeptidase (FGCP), and N-acetylated-alpha-linked acidic dipeptidase I (NAALADase I). In the brain, PSMA hydrolyzes the neurotransmitter N-acetyl-Asp-Glu to produce glutamate, another neurotransmitter. (rndsystems.com)
  • Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme [electronic resource]. (usda.gov)
  • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. (invivogen.com)
  • Identification of Carboxypeptidase N as the plasma enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1 alpha. (nih.gov)
  • Importance: COVID-19 is caused by SARS-CoV-2, a betacoronavirus that uses the angiotensin-converting enzyme-related carboxypeptidase (ACE2) receptor to gain entry into cells. (unav.edu)
Pancreatic1
  • A cDNA containing the porcine pancreatic pro-Carboxypeptidase B (proCPB) fused to the Saccharomyces cerevisiae alpha factor secretion signal was cloned into the pPIC3K vector under control of P. pastoris AOX1 promoter. (recombinanttrypsin.com)
Glutamate carboxypeptidase6
  • 2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) (IC50=300 pM). (cymitquimica.com)
  • 2-Phosphonomethylpentanedioic acid (1, 2-PMPA) is a potent inhibitor of glutamate carboxypeptidase II which has demonstrated robust neuroprotective efficacy in many neurological disease models. (elsevier.com)
  • Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. (yale.edu)
  • Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is an important diagnostic and therapeutic target in prostate cancer. (urotoday.com)
  • Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. (uib.no)
  • Association of glutamate carboxypeptidase II (GCPII) haplotypes with breast and prostate cancer risk. (cdc.gov)
Proteins2
  • Combined proteomics and transcriptomics identifies carboxypeptidase B1 and nuclear factor ?B (NF-?B) associated proteins as putative biomarkers of metastasis in low grade breast cancer, Mol. (muni.cz)
  • Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. (nih.gov)
Form a unique fingerprint1
  • Dive into the research topics of 'Methods for studying carboxypeptidase E'. Together they form a unique fingerprint. (elsevier.com)
Arginine carboxypeptidase1
Peptides1
  • Carboxypeptidase B2 preferentially releases the C-terminal amino acids Arg and Lys from biologically active peptides such as Kinins and Anaphylatoxins thus rendering them inactive. (abbiotec.com)
Endopeptidase3
  • Furthermore, the dual prolyl carboxypeptidase (PCP)-prolyl endopeptidase (PEP) inhibitor Z-prolyl-prolinal reduced ANG-(1-7) formation in ACE2 KO mice, while the ACE2 inhibitor MLN-4760 had no effect. (nih.gov)
  • In fact, the proteases have endopeptidase as well as exopeptidase (amino and carboxypeptidase) activities. (healthynewage.com)
  • It possesses both endopeptidase and dipeptidyl carboxypeptidase activites. (immunochemistry.com)
Putative2
  • We have generated a molecular model of CPE, and structural alignment with other carboxypeptidases revealed a putative sorting signal binding domain that is independent of the enzymatic site. (nih.gov)
  • Four mutants were killed exclusively by lysozyme and not other cell wall-targeting molecules, including the peptidoglycan deacetylase encoded by pgdA, the putative carboxypeptidase encoded by pbpX, the orphan response regulator encoded by degU, and the highly abundant noncoding RNA encoded by rli31. (pasteur.fr)
Recombinant6
  • Recombinant Carboxypeptidase B, ≥170 USP Units/Mg Pro. (recombinanttrypsin.com)
  • Recombinant Carboxypeptidase B is expressed in E.Coli and purified by high pressure liquid chromatography. (recombinanttrypsin.com)
  • Stability:A sterile recombinant carboxypeptidase B lyophilized eliminates the risk of contamination and decreases the chances of activity loss in the process of transport and storage. (recombinanttrypsin.com)
  • 1) Recombinant carboxypeptidase B provides increased specific activity and eliminates contaminating proteases activities found in extracted enzymes with lower purity level. (recombinanttrypsin.com)
  • Recommend recombinant carboxypeptidase B lyophilized should be stored under 2-8℃ in sealed container. (recombinanttrypsin.com)
  • VORAXAZE (glucarpidase) is a carboxypeptidase produced by recombinant DNA technology in genetically modified Escherichia coli . (druglib.com)
Prolyl carboxypeptidase1
  • Deletion of prolyl carboxypeptidase attenuates the metabolic effects o" by Jin Kwon Jeong, Gyorgyi Szabo et al. (gwu.edu)
Chymotrypsin1
  • In this report the general principles and potential application of affinity chro- matography are illustrated by results of its application to the purification of staphy- lococcal nuclease, a-chymotrypsin, and carboxypeptidase A. The solid matrix used in these studies was Sepharose (a "beaded" form of the cross-linked dextran of highly porous structure, agarose®) which displays virtually all the desirable fea- tures listed above. (nih.gov)
Cleaves1
Residues1
  • The conservative Leu211 and Leu254 residues (also present in both carboxypeptidase A and carboxypeptidase B) were shown to be structural determinants for recognition of hydrophobic substrates, whereas Asp263 was for recognition of positively charged substrates. (sigmaaldrich.com)
Antibody1
  • After overnight incubation, cells were stained using the Triton X100 fix/perm protocol (see Recommended Assay Procedure) and the anti-Carboxypeptidase E antibody. (bdbiosciences.com)
ABSTRACT1
  • abstract = "This chapter discusses the methods for studying carboxypeptidase E (CPE). (elsevier.com)
Lysine3
  • lysine carboxypeptidase. (expasy.org)
  • Carboxypeptidase B catalyzes hydrolysis of the basic amino acids lysine, arginine and histidine from the C-terminal end of polypeptides. (recombinanttrypsin.com)
  • Carboxypeptidase B is competitively inhibited by arginine and lysine. (recombinanttrypsin.com)
Exopeptidases1
  • Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. (nih.gov)
CPG21
  • carboxypeptidase G2 (CPG2), which hydrolyzes C-terminal glutamate-masking groups. (scienceboard.net)
Exopeptidase1
  • Carboxypeptidase E (CPE) also known as Neurotrophic factor-α1 (NF-α1), was first identified as an exopeptidase and is highly expressed in the nervous and endocrine systems. (nih.gov)
Glucarpidase1
  • 5. Glucarpidase (carboxypeptidase g2) intervention in adult and elderly cancer patients with renal dysfunction and delayed methotrexate elimination after high-dose methotrexate therapy. (nih.gov)
Receptor1
  • The membrane-bound form of Carboxypeptidase E (CPE) was identified as a sorting receptor for the regulated secretory pathway through studies carried out in our lab. (nih.gov)
Extracellular2
  • A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. (nih.gov)
  • This study highlights the role of BRS1 in plant redox regulation and stress responses, which extends our understanding of extracellular serine carboxypeptidases. (researchsquare.com)
Plasma1
  • VORAXAZE is a carboxypeptidase indicated to reduce toxic plasma methotrexate concentration (greater than 1 micromole per liter) in adult and pediatric patients with delayed methotrexate clearance (plasma methotrexate concentrations greater than 2 standard deviations of the mean methotrexate excretion curve specific for the dose of methotrexate administered) due to impaired renal function. (nih.gov)
Hydrolyzes1
  • Some of the vancomycin resistance operons encode VanXY D,D-carboxypeptidase, which hydrolyzes both di- and pentapeptide. (rcsb.org)
Sterile1