Carboxylesterase: Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is involved in the detoxification of XENOBIOTICS and the activation of ester and of amide PRODRUGS.Carboxylic Ester Hydrolases: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.JapanTokyoHeavy Ions: Positively-charged atomic nuclei that have been stripped of their electrons. These particles have one or more units of electric charge and a mass exceeding that of the Helium-4 nucleus (alpha particle).Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.National Human Genome Research Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.Paraoxon: An organophosphate cholinesterase inhibitor that is used as a pesticide.Prodrugs: A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Interferon Inducers: Agents that promote the production and release of interferons. They include mitogens, lipopolysaccharides, and the synthetic polymers Poly A-U and Poly I-C. Viruses, bacteria, and protozoa have been also known to induce interferons.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesHydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.Skin Absorption: Uptake of substances through the SKIN.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Rats, Hairless: Mutant strains of rats that produce little or no hair. Several different homozygous recessive mutations can cause hairlessness in rats including rnu/rnu (Rowett nude), fz/fz (fuzzy), shn/shn (shorn), and nznu/nznu (New Zealand nude). Note that while NUDE RATS are often hairless, they are most characteristically athymic.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Ancitabine: Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Cytochrome P-450 CYP3A: A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Jejunum: The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

Localization of a candidate surfactant convertase to type II cells, macrophages, and surfactant subfractions. (1/410)

Pulmonary surfactant exists in the alveolus in several distinct subtypes that differ in their morphology, composition, and surface activity. Experiments by others have implicated a serine hydrolase in the production of the inactive small vesicular subtype of surfactant (N. J. Gross and R. M. Schultz. Biochim. Biophys. Acta 1044: 222-230, 1990). Our laboratory recently identified this enzyme in the rat as the serine carboxylesterase ES-2 [F. Barr, H. Clark, and S. Hawgood. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L404-L410, 1998]. In the present study, we determined the cellular sites of expression of ES-2 in rat lung using a digoxygenin-labeled ES-2 riboprobe. ES-2 mRNA was localized to type II cells and alveolar macrophages but not to Clara cells. Using a specific ES-2 antibody, we determined the protein distribution of ES-2 in the lung by immunohistochemistry, and it was found to be consistent with the sites of mRNA expression. Most of the ES-2 in rat bronchoalveolar lavage is in the surfactant-depleted supernatant, but ES-2 was also consistently localized to the small vesicular surfactant subfraction presumed to form as a consequence of conversion activity. These results are consistent with a role for endogenous lung ES-2 in surfactant metabolism.  (+info)

Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy. (2/410)

Several recent studies have examined the possibility of producing tumor-specific cytotoxicity with various enzyme/ prodrug combinations. The enzymes are targeted to tumor cells either with antibodies (ADEPT, antibody directed enzyme prodrug therapy) or with viruses (VDEPT). The goal of the present study was to identify an appropriate enzyme for use in activating the prodrug 7-ethyl-10-[4-(1-piper-idino)-1-piperidino]carbonyloxycamptothe cin (CPT-11). In this study, we compared the efficiency of CPT-11 metabolism by rabbit and human carboxylesterases in in vitro and in situ assays. Although the rabbit and human enzymes are very similar (81% identical; 86% homologous) and the active site amino acids are 100% identical, the rabbit enzyme was 100-1000-fold more efficient at converting CPT-11 to SN-38 in vitro and was 12-55-fold more efficient in sensitizing transfected cells to CPT-11. In vivo, Rh30 rhabdomyosarcoma cells expressing the rabbit carboxylesterase and grown as xenografts in immune-deprived mice were also more sensitive to CPT-11 than were control xenografts or xenografts expressing the human enzyme. Each of the three types of xenografts regressed when the mice were treated with CPT-11 given i.v. at 2.5 mg of CPT-11/kg/daily for 5 days/week for 2 weeks [(dx5)2] (one cycle of therapy), repeated every 21 days for a total of three cycles. However, following cessation of treatment, recurrent tumors were detected in seven of seven mice bearing control Rh30 xenografts and in two of seven mice bearing Rh30 xenografts that expressed the human enzyme. No tumors recurred in mice bearing xenografts that expressed the rabbit carboxylesterase. We conclude that rabbit carboxylesterase/CPT-11 may be a useful enzyme/prodrug combination.  (+info)

Relationship between amount of esterase and gene copy number in insecticide-resistant Myzus persicae (Sulzer). (3/410)

Overproduction of the insecticide-degrading esterases, E4 and FE4, in peach-potato aphids, Myzus persicae (Sulzer), depends on both gene amplification and transcriptional control, the latter being associated with changes in DNA methylation. The structure and function of the aphid esterase genes have been studied but the determination of their copy number has proved difficult, a common problem with gene amplification. We have now used a combination of pulsed-field gel electrophoresis and quantitative competitive PCR to determine relative esterase gene copy numbers in aphid clones with different levels of insecticide resistance (R1, R2 and R3). There are approx. 4-fold increases between susceptible, R1, R2 and R3 aphids, reaching a maximum of approx. 80 times more genes in R3; this gives proportionate increases in esterase protein relative to susceptible aphids. Thus there is no overexpression of the amplified genes, in contrast with what was thought previously. For E4 genes, the loss of 5-methylcytosine is correlated with a loss of expression, greatly decreasing the amount of enzyme relative to the copy number.  (+info)

Establishment of an activated macrophage cell line, A-THP-1, and its properties. (4/410)

A new macrophage cell line with activated character and unique morphology was isolated by selecting adherent cells from the human monocytic cell line THP-1. The original THP-1 cells had been cultured for more than 9 years using 25 cm2 flasks, when cells with a different morphology appeared, adhering to the bottoms of the culture flasks. These were selected by discarding floating nonadherent cells at every subculture. Enrichment of adherent THP-1 cells with long processes proceeded during the cultivation. These adherent THP-1 showed remarkable phenotypic changes, not only morphologically, but also functionally. Namely, increased phagocytic activity, HLA-DR expression and MLR stimulator activity were remarkable. This adherent cell line was designated as activated-THP-1 (A-THP-1), since it demonstrated characteristics of activated macrophages continuously without exogenous stimulation. A cloned A-THP-1 cell line (A-THP-1 C1) also showed the same features and contained about 10% multinucleated giant cells probably caused by cell fusion. This A-THP-1 cell line, the first activated macrophage cell line to be established, provides a good model for understanding of activation mechanisms of macrophages and multinucleation. In this paper, morphological, immunological, and biological characters of this cell line are described.  (+info)

Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. (5/410)

Previous studies identified two intrinsic endoplasmic reticulum (ER) proteins, 11beta-hydroxysteroid dehydrogenase, isozyme 1 (11beta-HSD) and the 50-kDa esterase (E3), sharing some amino acid sequence motifs in their N-terminal transmembrane (TM) domains. Both are type II membrane proteins with the C terminus projecting into the lumen of the ER. This finding implied that the N-terminal TM domains of 11beta-HSD and E3 may constitute a lumenal targeting signal (LTS). To investigate this hypothesis we created chimeric fusions using the putative targeting sequences and the reporter gene, Aequorea victoria green fluorescent protein. Transfected COS cells expressing LTS-green fluorescent protein chimeras were examined by fluorescent microscopy and electron microscopic immunogold labeling. The orientation of expressed chimeras was established by immunocytofluorescent staining of selectively permeabilized COS cells. In addition, protease protection assays of membranes in the presence and absence of detergents was used to confirm lumenal or the cytosolic orientation of the constructed chimeras. To investigate the general applicability of the proposed LTS, we fused the N terminus of E3 to the N terminus of the NADH-cytochrome b5 reductase lacking the myristoyl group and N-terminal 30-residue membrane anchor. The orientation of the cytochrome b5 reductase was reversed, from cytosolic to lumenal projection of the active domain. These observations establish that an amino acid sequence consisting of short basic or neutral residues at the N terminus, followed by a specific array of hydrophobic residues terminating with acidic residues, is sufficient for lumenal targeting of single-pass proteins that are structurally and functionally unrelated.  (+info)

Inactivation and loss of antigenicity of esterase by sugars and a steroid. (6/410)

Glycation, the non-enzymic reaction of sugars with proteins, has an important role in the complications of diabetes. It has been studied mostly in structural proteins but more recently has been shown to inactivate enzymes. Previous evidence from our laboratory indicated that glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase are simultaneous. Esterase, which decreases activity in the lens in senile cataract and diabetes, was measured by a spectrophotometric assay using p-nitrophenyl acetate as the substrate. Here we investigated the inactivation of carboxylesterase (EC 3.1.1.1) by sugars of different glycating power and prednisolone-21-hemisuccinate while simultaneously monitoring the loss of antigenicity. Antigenicity was assessed by immunoprecipitation and by dot-blotting the glycated and non-glycated fractions of enzymes separated by affinity chromatography. Ribose and fructose inactivated more rapidly than glucose and glucose 6-phosphate. The esterase was progressively inactivated by prednisolone-21-hemisuccinate at a lower concentration. Activity and antigenicity were lost simultaneously. The glycated enzyme had entirely lost its antigenicity. These results further support the idea that inactivation of enzyme and loss of antigenicity are simultaneous.  (+info)

A non-AUG-defined alternative open reading frame of the intestinal carboxyl esterase mRNA generates an epitope recognized by renal cell carcinoma-reactive tumor-infiltrating lymphocytes in situ. (7/410)

A number of Ags recognized by tumor-reactive T cells have been characterized, including nonmutated gene products and a variety of epitopes shown to arise from either mutated or alternatively processed transcripts. Here, we report that the screening of a cDNA library with an HLA-B7-restricted renal cell carcinoma-reactive T cell clone derived from tumor-infiltrating lymphocytes (TILs) that were clonally amplified in vivo (as assessed by TCRBV complementarity determining region-3 length distribution analysis) resulted in the isolation of a nonamer encoded by an alternative open reading frame (ORF) (a +1 frameshift) of the intestinal carboxyl esterase gene. This peptide binds HLA-B*0702-presenting molecules as assessed in an immunofluorescence-based peptide binding assay using transfected T2 cells. Constitutive expression of this alternative ORF protein was observed in all transformed HLA-B7+ renal cell lines that were recognized in cytotoxicity assays by the TILs. The intestinal carboxyl esterase gene is transcribed in renal cell carcinoma tumors as well as in normal liver, intestinal, or renal tissues. Mutation of the natural ATG translation initiation site did not alter recognition, indicating that frameshifting (i.e., slippage of the ribosome forward) and recoding are not involved. In addition, a point mutation of the three AUG codons that may be used as alternative translation initiation sites in the +1 ORF did not abolish recognition, whereas mutation of an upstream ACG codon did, indicating that the latter codon initiates the translation of the alternative ORF. These results further extend the types of Ags that can be recognized by tumor-reactive TILs in situ (i.e., leading to clonal T cell expansion).  (+info)

Microsomal long-chain acyl-CoA thioesterase (carboxylesterase ES-4) is regulated by thyroxine. (8/410)

Long chain acyl-CoA thioesterase activity is mainly located in microsomes after subcellular fractionation of liver from untreated rats. The physiological function and regulation of expression of this activity is not known. In the present study we have investigated the effect of thyroxine on expression of carboxylesterase ES-4, the major acyl-CoA thioesterase of liver microsomes. Thyroidectomy of rats decreased the palmitoyl-CoA thioesterase activity to about 25% of normal activity. This decrease was accompanied by similar decreases at the protein and mRNA levels (31% and 57%, respectively, of controls). Treatment with thyroxine completely reversed the effect of thyroidectomy and resulted in elevated levels in both thyroidectomized and control rats. For reasons of comparison we also studied the possibility that ES-10 and ES-2, two other members of the same gene family, are affected by thyroxine. ES-10 was not changed at the protein or mRNA level by any of the treatments, while ES-2 expression in liver was decreased by thyroxine treatment. The data shows that changes in activity and expression of ES-4 correlate to thyroxine status in the rat suggesting a physiological regulatory role by this hormone. Since thyroxine regulates the expression of lipogenic enzymes, these results are consistent with a function for this microsomal acyl-CoA thioesterase in fatty acid synthesis and/or secretion, rather than in oxidative degradation of fatty acids.  (+info)

*Carboxylesterase

... carboxylesterase 1 carboxylesterase 2 carboxylesterase 3 esterase A, esterase B, esterase D, methylbutyrase, methylbutyrate ... In enzymology, a carboxylesterase or carboxylic-ester hydrolase (EC 3.1.1.1) is an enzyme that catalyzes a chemical reaction of ... The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a ... Humans genes that encode carboxylesterase enzymes include: CES1 CES2 CES3 CES4 CES7 CES8 An approved nomenclature has been ...

*Carboxylesterase 3

... is an enzyme that in humans is encoded by the CES3 gene. Carboxylesterase 3 is a member of a large multigene ... "Entrez Gene: CES3 carboxylesterase 3 (brain)". Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies ... Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse ... and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505-11. doi:10.1124/dmd.32.5.505. PMID ...

*Carboxylesterase 2

"Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)". Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic ... Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. It is a member of the alpha/beta fold hydrolase ... Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the ... 2005). "Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38". Clin. ...

*Carboxylesterase 1

Liver carboxylesterase 1 also known as carboxylesterase 1 (CES1, hCE-1 or CES1A1) is an enzyme that in humans is encoded by the ... Carboxylesterase 1 is a serine esterase and member of a large multigene carboxylesterase family. It is also part of the alpha/ ... "Entrez Gene: CES1 carboxylesterase 1 (monocyte/macrophage serine esterase 1)". Imai T (Jun 2006). "Human Carboxylesterase ... Carboxylesterase 1 deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Inhibition of CES1 by ...

*Carboxylesterase family

Carboxylesterase, type B is a family of evolutionarily related proteins. Higher eukaryotes have many distinct esterases. The ... Carboxylesterase Nachon F, Asojo OA, Borgstahl GE, Masson P, Lockridge O (February 2005). "Role of water in aging of human ... IPR000997 Human genes that encode proteins containing the carboxylesterase domain include: ACHE ARACHE BCHE CEL CES1 CES2 CES3 ...

*Acetylcholinesterase

It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as ...

*Ritalinic acid

The hydrolysis was found to be catalyzed by carboxylesterase 1 (CES1). Faraj, B. A.; Israili, Z. H.; Perel, J. M.; Jenkins, M. ... "Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1". The Journal of Pharmacology and Experimental ...

*Methylphenidate

"Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1". The Journal of Pharmacology and Experimental ...

*Pyrethroid hydrolase

Wang, B.Z.; Guo, P.; Hang, B.J.; Li, L.; He, J.; Li, S.P. (2009). "Cloning of a novel pyrethroid-hydrolyzing carboxylesterase ... Pyrethroid hydrolase (EC 3.1.1.88, pyrethroid-hydrolyzing carboxylesterase, pyrethroid-hydrolysing esterase, pyrethroid- ... and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes". J. Biol. Chem. 279: 29863-29869. ...

*Pethidinic acid

Metabolism of pethidine to pethidinic acid is carried out mainly by the carboxylesterase enzyme hCE-1 in the liver, and since ... Binding and hydrolysis of meperidine by human liver carboxylesterase hCE-1. Journal of Pharmacology and Experimental ...

*Ferroplasma

"Structural Insights into the Low pH Adaptation of a Unique Carboxylesterase from Ferroplasma". Journal of Biological Chemistry ...

*Diethyl phthalate

DEP is metabolized by carboxyl esterase, which is synthesized in the human liver. In vitro studies show that DEP reduces the ...

*Butyl acrylate

In rodent models, butyl acrylate is metabolized by carboxylesterase or reactions with glutathione; this detoxification produces ...

*Haloterrigena turkmenica

Selim, Samy; Hagagy, Nashwa (2016-03-01). "Genome sequence of carboxylesterase, carboxylase and xylose isomerase producing ... and carboxylesterase. Other genes coding for biosynthesis of peptides and secondary metabolites were also detected. ...

*Ramipril

... , a prodrug or precursor drug, is converted to the active metabolite ramiprilat by carboxylesterase 1. Ramiprilat is ... Jan 2014). "In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors". Drug ...

*Pimelyl-(acyl-carrier protein) methyl ester esterase

... a new carboxylesterase from Escherichia coli". J. Biol. Chem. 278: 26039-26045. doi:10.1074/jbc.M303867200. PMC 2792009 . PMID ...

*Arthrobacter globiformis

"Identification of the Catalytic Residues of Carboxylesterase from by Diisopropyl Fluorophosphate-Labeling and Site-Directed ...

*Acetylsalicylate deacetylase

White KN, Hope DB (1984). "Partial purification and characterization of a microsomal carboxylesterase specific for salicylate ...

*Glutamyl endopeptidase I

"Molecular cloning of the carboxylesterase gene and biochemical characterization of the encoded protein from Pseudomonas ...

*Ethylphenidate

This carboxylesterase-dependent transesterification process is also known to occur when cocaine and alcohol are consumed ... Bourland, J.; Martin, D.; Mayersohn, M. (1997). "Carboxylesterase-mediated transesterification of meperidine (Demerol) and ...

*Cocaine esterase

... (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2) is an enzyme with systematic name cocaine ... "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine ...

*Rotor syndrome

2013). OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and ...

*Landiolol

It is rapidly hydrolyzed to an inactive form by both carboxylesterase in the liver and pseudocholinesterase in the plasma, ...

*Cocaethylene

The hepatic enzyme carboxylesterase is an important part of cocaine's metabolism because it acts as a catalyst for the ... cocaine + H2O → benzoylecgonine + methanol (with liver carboxylesterase 1) benzoylecgonine + ethanol → cocaethylene + H2O ... cocaine + ethanol → cocaethylene + methanol (with liver carboxylesterase 1) Cocaethylene is largely considered a recreational ...

*Tenofovir alafenamide

... carboxylesterase 1 and histidine triad nucleotide-binding protein 1) "GENVOYA (elvitegravir, cobicistat, emtricitabine, and ...
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In enzymology, a carboxylesterase or carboxylic-ester hydrolase (EC 3.1.1.1) is an enzyme that catalyzes a chemical reaction of the form a carboxylic ester + H2O ⇌ {\displaystyle \rightleftharpoons } an alcohol + a carboxylate Thus, the two substrates of this enzyme are carboxylic ester and H2O, whereas its two products are alcohol and carboxylate. Most enzymes from this group are serine hydrolases belonging to the superfamily of proteins with alpha/beta hydrolase fold. Some exceptions include an esterase with beta-lactamase like structure (PDB: 1ci8​). Carboxylesterases are widely distributed in nature, and are common in mammalian liver. Many participate in phase I metabolism of xenobiotics such as toxins or drugs; the resulting carboxylates are then conjugated by other enzymes to increase solubility and eventually excreted. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate ...
Irinotecan is a relatively new anticancer agent of interest for both its clinical activity and its complex clinical pharmacology. It is a prodrug, requiring activation by carboxylesterases to SN-38, an inhibitor of topoisomerase I. Recent studies suggest that human carboxylesterase-2 is the primary carboxylesterase involved in the hydrolysis at pharmacological concentrations (1) . Irinotecan is also oxidized by CYP3A43 to the inactive metabolite 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin as well as to 7-ethyl-10-[4-(piperidino)-1-amino]carbonyloxycamptothecin, which can undergo hydrolysis to SN-38 (2, 3, 4) . SN-38 undergoes glucuronidation by UGT1A1 (5) and is possibly oxidized by CYP3A4 as well (6) . Mass balance studies have demonstrated that 64% of the total dose is excreted in the feces, confirming the important role of biliary excretion (7) . Studies suggest that canalicular multispecific organic anion transporter is the major transporter of irinotecan and ...
Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to Study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n = 78 pairs, P = 8.7 x 10(-18)) and brothers (n = 12 Pairs, P = 0.048). CES1 expression was higher in subcutaneous compared with omental adipose tissue in lean (P = 0.027) and obese Subjects (P = 0.00036), and reduced during diet-induced weight loss (it = 24, weeks 8, 16, and 18 compared to baseline, P , 0.0001 for all time points). CES1 expression was higher in isolated adipocytes compared with intact adipose tissue (P = 0.0018) and higher in large compared with small adipocytes (P = 4.1 x 10(-6)). Basal and Stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity. (C) 2009 Elsevier Inc. All ...
The use of a prodrug, a conjugate of an active drug with a lipophilic substituent, is a good way of increasing the cutaneous absorption of a drug. However, the activity of dermal hydrolases has rarely been investigated in humans, or experimental animals. In the present study, we focused on the identification of rat dermal esterases and the hydrolysis of a prodrug during permeation across rat skin. We found that carboxylesterase (CES), especially the rat CES1 isozyme, Hydrolase A, is expressed in rat skin and that the hydrolysis of p-nitrophenyl acyl derivatives and caproyl-propranolol (PL) was 20-fold lower in the 9000g supernatant fraction of skin homogenate than in liver microsomes. A permeation study of caproyl-PL was performed in rat full-thickness and stripped skin using a flow-through diffusion cell. Caproyl-PL was easily partitioned into the stratum corneum and retained, not only in the stratum corneum, but also in viable epidermis and dermis. Caproyl-PL could barely be detected in the receptor
Measurement of Carboxylesterase (CES) Activities (Masakiyo Hosokawa, Chiba University, Chiba, Japan and Tetsuo Satoh, Biomedical Research Institute, Chiba, Japan)
CES2 Antibody (monoclonal) (M02), Mouse monoclonal antibody raised against a partial recombinant CES2. validated in WB, IHC, E (AT1499a), Abgent
A near-infrared fluorescent probe (DDAB) for highly selective and sensitive detection of carboxylesterase 2 (CE2) has been designed, synthesized, and systematically studied both in vitro and in vivo. Upon addition of CE2, the ester bond of DDAB could be rapidly cleaved and then release a near-infrared (NIR) fluorophore DDAO, which brings a remarkable yellow-to-blue color change and strong NIR fluo ...
The "holy grail" of pharmacology is the ability to specifically target the cell type responsible for a disease. Given that many drugs act intracellularly on targets that are active in most cells in the body, targeting specificity could be used to reduce unwanted side effects and toxicities. Needham et al. have investigated the development of a chemical platform that enhances the potency and delivery of small-molecule drugs to intracellular targets. Attaching a small esterase-sensitive chemical motif (ESM) that is selectively hydrolyzed by an intracellular carboxylesterase human carboxylesterase-1 (hCE1) allows small-molecule inhibitors to be released as charged, pharmacologically active drugs specifically in monocytes and macrophages. An ESM-linked histone deacetylase (HDAC) inhibitor showed impressive anticytokine and antiarthritic activity in hCE1 knock-in mice. The activity of the HDAC ESM (CHR4487) was demonstrated in human whole blood with anticytokine activity observed at concentrations ...
Landowski, Christopher P. et al "Nucleoside Ester Prodrug Substrate Specificity of Liver Carboxylesterase." Journal of Pharmacology and Experimental Therapeutics 316.2 (2006): 572-580. Web. 29 Mar. 2020. ...
Where did the nylon-eating ability come from? Carboxylesterases are enzymes with broad substrate specificities; they can carry out a variety of reactions. Their binding pocket is large and can accommodate a lot of different substrates. They are "promiscuous" enzymes, in other words. Furthermore, the carboxylesterase reaction hydrolyzes a chemical bond similar to the one hydrolyzed by nylonase.. […]. From Kato et al. (1991):. "Our studies demonstrated that among the 47 amino acids altered between the EII and EII proteins, a single amino acid substitution at position 181 was essential for the activity of 6-aminohexanoate-dimer hydrolase [nylonase] and substitution at position 266 enhanced the effect.". So. This is not the story of a highly improbable frame-shift producing a new functional enzyme. This is the story of a pre-existing enzyme with a low level of promiscuous nylonase activity, which improved its activity toward nylon by first one, then another selectable mutation. In other words ...
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As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. The sequence around the active site serine is well conserved and can be used as a signature pattern. As a second signature pattern, we selected a conserved region located in the N-terminal section and which contains a cysteine involved in a disulfide bond. Note: Human esterase-D, also a type-B carboxylesterase, does not seem to be evolutionary related. Expert(s) to contact by email: Sussman J ...
Complete information for ESD gene (Protein Coding), Esterase D, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Human CES7 full-length ORF (BAB71094.1, 1 a.a. - 525 a.a.) recombinant protein with GST-tag at N-terminal. (H00221223-P01) - Products - Abnova
Seriole, esp ces diverses - Tout ce que vous devez savoir propos de laliment Seriole, esp ces diverses : Toutes les informations nutritionnelles de Seriole, esp ces diverses
Mollusques, mye (palourde), esp ces diverses - Tout ce que vous devez savoir propos de laliment Mollusques, mye (palourde), esp ces diverses : Toutes les informations nutritionnelles de Mollusques, mye (palourde), esp ces diverses
走這路… 正如你所知道的有, 或知道誰的人有, 馬尾綜合徵, 它使你的行走步態的嘲弄. 我已經描述自己是走路像科學怪人. 現在到了新的, 這CES做有趣的事情. 感覺已經開始返回到我的腳踝兩側. 因為它有, 我已經… 更多精彩閱讀… ...
Looking for online definition of carboxylesterase 2 in the Medical Dictionary? carboxylesterase 2 explanation free. What is carboxylesterase 2? Meaning of carboxylesterase 2 medical term. What does carboxylesterase 2 mean?
Any risk of strain JPL-2, with the capacity of degrading fenoxaprop-P-ethyl (FE), was isolated from the soil of the wheat line of business and defined as JPL-2, FE -hydrolyzing carboxylesterase gene Introduction Fenoxaprop-ethylethyl-2-(4-((6-chloro-2-benzoxazolyl)oxy) phenoxy) propanoate) (FE) is normally a representative of aryloxyphenoxy propanoate (AOPP) herbicides. their matching acid type (Nie sp. B2 could degrade clodinafop propargyl (CF) to clodinafop acidity and 4-(4-Chloro-2-fluoro-phenoxy)-phenol (Singh, 2013). In summary, step one in the degradation of AOPP herbicides, which is normally distributed among these strains, may be the break down of the carboxylic acidity ester bond with a carboxylesterase. Far Thus, just two genes encoding this enzyme have already been cloned: from QDZ-1 and from sp. T1. Nevertheless, the features of FeH possess yet to become investigated. In this study: JPL-2, an aryloxyphenoxy propanoate (AOPP) herbicide-degrading strain of was cloned and expressed; and ...
Carboxylesterases hydrolyze numerous endogenous and foreign compounds with diverse structures. Humans and rodents express multiple forms of carboxylesterases, which share a high degree of sequence identity (∼70%). Alignment analyses locate in carboxylesterases several functional subsites such the catalytic triad as seen in acetylcholinesterase. The aim of this study was to determine among human and rodent carboxylesterases the immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, tissue distribution, and tumor-related expression. Six antibodies against whole carboxylesterases or synthetic peptides were tested for their reactivity toward 11 human or rodent recombinant carboxylesterases. The antibodies against whole proteins generally exhibited a broader cross-reactivity than the anti-peptide antibodies. All carboxylesterases hydrolyzed para-nitrophenylacetate and para-nitrophenylbutyrate. However, the relative activity varied markedly from ...
cell wall, extracellular region, acylglycerol lipase activity, carboxylic ester hydrolase activity, short-chain carboxylesterase activity, medium-chain fatty acid catabolic process, monoacylglycerol catabolic process, short-chain fatty acid catabolic process
https://doi.org/10.18632/oncotarget.23619 Dominique Lombardo, Françoise Silvy, Isabelle Crenon, Emmanuelle Martinez, Aurélie Collignon, Evelyne Beraud, Eric Mas
Five mouse anti-human butyrylcholinesterase (BChE) monoclonal antibodies bind tightly to native human BChE with nanomolar dissociation constants. Pairing analysis in the Octet system identified the monoclonal antibodies that bind to overlapping and independent epitopes on human BChE. The nucleotide and amino acid sequences of 4 monoclonal antibodies are deposited in GenBank. Our goal was to determine which of the 5 monoclonal antibodies recognize BChE in the plasma of animals. Binding of monoclonal antibodies 11D8, B2 18-5, B2 12-1, mAb2 and 3E8 to BChE in animal plasma was measured using antibody immobilized on Pansorbin cells and on Dynabeads Protein G. A third method visualized binding by the shift of BChE activity bands on nondenaturing gels stained for BChE activity. Gels were counterstained for carboxylesterase activity. The three methods agreed that B2 18-5 and mAb2 have broad species specificity, but the other monoclonal antibodies interacted only with human BChE, the exception being ...
Port Phillip Bay, Australia, is a large semi-closed bay with over four million people living in its catchment basin. The Bay receives waters from the Yarra River which drains the city of Melbourne, as well as receiving the discharges of sewage treatment plants and petrochemical and agricultural chemicals. A 1999 study demonstrated that fish inhabiting Port Phillip Bay showed signs of effects related to pollutant exposure despite pollution management practices having been implemented for over a decade. To assess the current health status of the fish inhabiting the Bay, a follow up survey was conducted in 2015. A suite of biomarkers of exposure and effects were measured to determine the health status of Port Phillip Bay sand flathead (Platycephalus bassensis), namely ethoxyresorufin-O-deethylase (EROD) activity, polycyclic aromatic hydrocarbons (PAH) biliary metabolites, carboxylesterase activity (CbE) and DNA damage (8-oxo-dG). The reduction in EROD activity in the present study suggests a ...
Cocaethylene (ethylbenzoylecgonine) is the ethyl ester of benzoylecgonine. It is structurally similar to cocaine, which is the methyl ester of benzoylecgonine. Cocaethylene is formed by the liver when cocaine and ethanol coexist in the blood. Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver. Normally, metabolism of cocaine produces two primarily biologically inactive metabolites-benzoylecgonine and ecgonine methyl ester. The hepatic enzyme carboxylesterase is an important part of cocaines metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver, which produces these inactive metabolites. If ethanol is present during the metabolism of cocaine, a portion of the cocaine undergoes transesterification with ethanol, rather than undergoing hydrolysis with water, which results in the production of cocaethylene. cocaine + H2O → benzoylecgonine + methanol (with liver carboxylesterase 1) benzoylecgonine + ethanol → ...
Transcription and expression regulation of some individual cel genes (cel5A, cel5I, cel5D and cel44O) of Clostridium cellulolyticum were investigated. Unlike the cip-cel operon, these genes are transcribed as monocistronic units of transcription, except cel5D. The location of the transcription initiation sites was determined using RT-PCR and the mRNA 5′-end extremities were detected using primer extension experiments. Similarly to the cip-cel operon, cel5A and cel5I expressions are regulated by a carbon catabolite repression mechanism, whereas cel44O and cel5D expressions do not seem to be submitted to this regulation. The role of the putative transcriptional regulator GlyR2 in the regulation of cel5D expression was investigated. The recombinant protein GlyR2 was produced and was shown to bind in vitro to the cel5D and glyR2 promoter regions, suggesting that besides regulating its own expression, GlyR2 may regulate cel5D expression. To test this hypothesis in vivo, an insertional glyR2 mutant ...
A new ratiometric fluorescent probe derived from 2-(2-hydroxy-3-methoxyphenyl) benzothiazole (HMBT) has been developed for selective monitoring of human carboxylesterase 1 (hCE1). The probe is designed by introducing benzoyl moiety to HMBT. The prepared latent spectroscopic probe 1 displays satisfying stability under physiological pH conditions with very low background signal. Both the reaction phynotyping and chemical inhibition assays demonstrated that hCE1 mediated the specific cleavage of the carboxylic ester bond of probe 1 in human biological samples. The release of HMBT leads to a remarkable red-shifted emission in fluorescence spectrum (120 nm large emission shift). Furthermore, human cell-based assays show that probe 1 is cell membrane permeable, and it can be used for bioassay and cellular imaging of hCE1 activity in HepG2 cells. These findings lead to the development of a simple and sensitive fluorescent method for measurement of hCE1 activity in vitro or in living cells, in the ...
Background The main toxicity of irinotecan in advanced colorectal cancer (CRC) is delayed diarrhoea. Intestinal SN-38, released by deconjugation of the parent glucuronide excreted into the bile or produced in situ by intestinal carboxylesterase, is toxic to the intestinal epithelium. The canalicular transport of irinotecan and SN-38G is mediated by ABCC2 (MRP2) and ABCB1 (MDR1) which are both inhibited by ciclosporin. We tested whether irinotecan and ciclosporin was non-inferior for anti-cancer efficacy and superior for toxicity compared with single-agent irinotecan. Methods Six hundred and seventy-two patients with advanced, measurable CRC following prior fluoropyrimidine- containing chemotherapy were randomised to either irinotecan 3-weekly 350 mg/m 2 (or 300 mg/m 2 if age | 70 or performance status (PS) = 2) or 3-weekly irinotecan at 140 mg/m 2 (120 mg/m 2 if age | 70 or PS = 2) with ciclosporin 3 mg/kg t.d.s. for three days by mouth starting on the morning before irinotecan. The primary end
Cocaine is a carboxylesterase substrate predominantly eliminated by hydrolysis to BE and EME (Fig. 1) by CES1 and CES2 (Isenschmid et al., 1992; Dean et al., 1995; Kamendulis et al., 1996; Cone et al., 1998), and it is one of the few carboxylesterase substrates whose interaction with ethanol has been studied extensively. Studies of the effect of ethanol on cocaine pharmacokinetics have focused on the pharmacodynamic interaction in drug abuse and have reported on administration of cocaine by the intravenous, intraperitoneal, nasal, and smoking routes (Farré et al., 1993; Cami et al., 1998; Laizure et al., 2003). All of these routes of administration bypass the first-pass metabolism of cocaine either completely (intravenous and smoking) or partially (intraperitoneal and intranasal). These studies, performed in both humans and animal models, consistently demonstrate that the coadministration of ethanol inhibits the metabolism of cocaine given by nonoral (intravenous, smoking, intraperitoneal, and ...
A scarce number of tests with terrestrial organisms are available for the category members of the Short Chain Alcohol Esters. As the category members of the Short Chain Alcohol Esters (SCAE) are readily biodegradable, ready degradation into metabolites is postulated. Fatty acids have been shown to have a low potential for bioaccumulation when considering biotransformation and the omnipresent activity of the enzyme carboxylesterase. Fatty acids and alcohols are the main metabolites of fatty acid esters. These components occur in soils naturally and are part of physiological pathways and can be used as energy source. The enzyme carboxylesterase is omnipresent in the environment. Bioaccumulation in organisms birds feed on are not expected. Furthermore, low toxicity to rats (repeated dose oral, NOAEL(90d) = 6000 mg/kg bw/d) was found. As a result, a low potential for secondary poisoning of birds is expected. Further testing should not be conducted due to animal welfare. ...
Non-P-glycoprotein-mediated multidrug-resistant C-A120 cells that overexpressed multidrug resistance protein (MRP) were 10.8- and 29.6-fold more resistant to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) and SN-38, respectively, than parental KB-3-1 cells. To see whether MRP is involved in CPT-11 and SN-38 resistance,MRP cDNA was transfected into KB-3-1 cells. The transfectant, KB/MRP, which overexpressed MRP, was resistant to both CPT-11 and SN-38. 2-[4-Diphenylmethyl)-1-piperazinyl]ethyl-5-(trans-4,6-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate P-oxide (PAK-104P) and MK571, which reversed drug resistance in MRP overexpressing multidrug-resistant cells, significantly increased the sensitivity of C-A120 and KB/MRP cells, but not of KB-3-1 cells, to CPT-11 and SN-38. The accumulation of both CPT-11 and SN-38 in C-A120 and KB/MRP cells was lower than that in KB-3-1 cells. The treatment with 10 μM PAK-104P increased the ...
Irinotecan (CPT-11) is now widely used as the first-line chemotherapy for mCRC. There were 4 key enzymes for CPT-11 metabolizing, CYP3A4, UDP-glucuronosyltransferase, carboxylesterase(CES), and ATP-binding cassette (ABC) transporters. Genetic variations of those enzymes may cause the heterogeneity in safety and efficacy of CPT-11. The aim of this study is to figure out the correlation between the genetic polymorphism and the drug response ...
4133 Individualized, tailored drug therapy is an important direction for development of cancer treatment. Currently, irinotecan (CPT-11) has been widely used in a variety of human cancers. Occasionally, occurrence of unexpected severe toxicities (Gr. 4 neutropenia, Gr. 4 diarrhea, sepsis) of irinotecan may hinder its clinical use. Irinotecan is activated by carboxylesterase to SN-38 with its antitumor activity, and which has been associated with the severe diarrheal episodes as a result of the direct enteric injury. SN-38 undergoes glucuronide conjugation and inactivation by UDP-glucuronosyl transferase 1A1 (UGT1A1) isoform to form the inactive SN-38 glucuronide (SN-38G). Among the UGT1A1 polymorphism, the UGT1A1*28 genotype, with (TA)7TAA change of UGT1A1 gene promoter, had probable important implications to predict and monitor clinical toxicity induced by irinotecan. We tried to analyze the polymorphisms in UGT1A1*28 genotype as predictors of severe toxic events occurring after irinotecan ...
Le Registre public des espèces en péril est une source complète dinformation publique sur des espèces en péril au Canada et la Loi sur les espèces en péril (LEP).
ISBN 9789898066343 - Get FREE shipping offers and dollar off coupons with our price comparison for Os Ces Nunca Mentem sobre o Amor Reflexes acerca do mundo emocional dos ces - ISBN 9789898066343, 9898066342.
Samsung's latest Creative Lab projects are shaping up to be some of their most innovative ideas yet. The projects, which will be shown off at CES next week, include the S-Ray portable directional speaker, the GoBreath lung damage recovery device…
Learn more about Parto por cesárea at Grand Strand Medical Center DefiniciónRazones para realizar el procedimientoPosibles complicaciones¿Qué...
CES 2017 took place from Jan 3-8th in Las Vegas. This years show was crazy big with interesting technology that has some unique potential.
Iriarte Corredora, Venta y arriendo de propiedades, administración de propiedades en arriendo, tasaciones de bienes raíces y terrenos.
Iriarte Corredora, Venta y arriendo de propiedades, administración de propiedades en arriendo, tasaciones de bienes raíces y terrenos.
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
All products sold and installed by CES are covered by factory warranties. The terms and conditions of these warranties vary from manufacturer to manufacturer. It is CESs commitment to honor and execute these warranties to their full extent where applicable. At all times,CES will strive to provide the swiftest, and most fair solutions to equipment warranty issues.. CES acts as an authorized factory representative for all warranty related claims. CES field personnel are not permitted to authorize warranty returns and claims at installation sites. Warranty determinations made at the job site may be subject to rejection or modification by the factory.. CES guarantees all labor for a period of one year from initial installation on equipment installed by CES personnel.. In cases where products are replaced by the factory, labor charges for removing and reinstalling equipment may be the customers responsibility and will be determined on a case by case basis.. Warranties do not cover cosmetic damage ...
All products sold and installed by CES are covered by factory warranties. The terms and conditions of these warranties vary from manufacturer to manufacturer. It is CESs commitment to honor and execute these warranties to their full extent where applicable. At all times,CES will strive to provide the swiftest, and most fair solutions to equipment warranty issues.. CES acts as an authorized factory representative for all warranty related claims. CES field personnel are not permitted to authorize warranty returns and claims at installation sites. Warranty determinations made at the job site may be subject to rejection or modification by the factory.. CES guarantees all labor for a period of one year from initial installation on equipment installed by CES personnel.. In cases where products are replaced by the factory, labor charges for removing and reinstalling equipment may be the customers responsibility and will be determined on a case by case basis.. Warranties do not cover cosmetic damage ...
Programme de rétablissement du naseux de Nooksack (Rhinichthys cataractae) au Canada; La Loi sur les espèces en péril (LEP) renforce et accroît la capacité du gouvernement du Canada de protéger les espèces et les sous-espèces sauvages;Le naseux de Nooksack est un petit poisson de moins de 15 cm, de la famille des cyprinidés (méné). Ce poisson élancé possède de larges nageoires pectorales et un long museau qui dépasse distinctement la bouche.
Im new here and seeking advice/insight. I just purchased a 79 L-5 CES which was apparently cased for most of the last 40 years. As a result, the celluloid pickguard gassed out from heat, corroding th
Amanda Congdon turns in some truly shocking coverage from CES, where she decides to test-drive the perp end of a personal taser. As painful as it looks, its only about half as wrenching as watching Amandas
An Audi A7 self-driving car prototype completed a trip of more than 550 miles from California to CES in Las Vegas on public roads.
Evidence of unstable or severe systemic illness, including but not limited to: Cardiovascular disease (e.g., chronic ventricular arrhythmia, unstable angina or CHF), respiratory disease (e.g., sleep apnea, COPD requiring oxygen therapy or hospitalization in last year), endocrine disease, hepatic disease (e.g., chronic active hepatitis), renal disease, or immunodeficiency ...
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Daugherty, Patrick J., Diane Keiser Beeman, and Michael R. Pelton. "Analysis of Electrophoretic Pattern of Nonspecific Esterases of Black Bear Serum." Journal of the Tennessee Academy of Science 54, no. 4 (1979): 128-131. ...
[QUOTE=shibz]Smile and MaNan Cr-Lostmymusic [/QUOTE] matlab what a kameena,itna kuch galat karne k baad bhi he wants her to smile for him.some confidence the guy has. i like how Nandu says meri smile bahot achi hai but you dont deserve it. Lol. mu tod jawab. | Page: 25 | 4610678 | Kaisi Yeh Yaariaan Forum
Identify and order parts using an interactive graphical navigator. Drill-down to exploded views that clearly illustrate components of interest. Access alternate views, video clips, and troubleshooting.
Parks Associates is an internationally recognized market research and consulting company specializing in emerging consumer technology products and services.
Shows the %age of participants who met specific weight-transformation thresholds 6 and 24 months after randomization. At two years, the %age of participants in
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When HRP was injected intraperitoneally (i.p.), labelled amoeboid microglial cells (AMC) were consistently localized in the subcortical white matter and circumventricular zones in early postnatal (1 and 7 days old) but absent in late postnatal (14-day-old) rats. The ingested HRP disappeared from the labelled cells 5 days after IP injection. Subcutaneous injection of HRP had also resulted in the labelling of amoeboid microglial cells in the corpus callosum of early postnatal rats. When the injected HRP was followed ultrastructurally over a time course sequence in intravenously (i.v.) injected rats, it was first detected in the invaginations on the luminal side of endothelium and in the endothelial cytoplasm 30 min after injection. HRP was present both in the endothelium and amoeboid microglial cells 3 hours later. With time, the tracer was progressively accumulated in the cytoplasm of AMC and it was sequestered in the vacuoles and lysosomes. It is concluded from this study that when injected ...
Edwardsiella tarda causes haemorrhagic septicaemia in fish and gastro- and extra-intestinal infections in animals including humans. Resistance to phagocyte-mediated killing is one of the virulence factors of Ed. tarda. The authors' previous studies using TnphoA transposon mutagenesis indicated that katB mutants derived from the strain PPD130/91 are at least 1·6 log higher in LD50 values than the wild-type strain. These findings suggest the involvement of catalase (KatB) in Ed. tarda pathogenesis. In this study, experiments were conducted to characterize the contribution of KatB to Ed. tarda infection. Zymographic analyses indicated that the 22 Ed. tarda strains examined expressed three different types of catalase-peroxidases (Kat1-3) based on their mobility in non-denaturing polyacrylamide gels. KatB (Kat1), the major catalase enzyme, was expressed in eight out of 22 Ed. tarda strains, and was commonly found in virulent strains except AL9379. AL9379 has a mutated katB, which has a base
Since they were identified in 1975, human astroviruses have been considered one of the most important agents of viral acute gastroenteritis in children. However, highly divergent astroviruses infecting humans have been recently discovered and associated with extra-intestinal infections. The report of cases of fatal meningitis and encephalitis, especially in immunocompromised individuals, has broadened their disease spectrum. Although zoonotic transmission among animal and human astroviruses has not been clearly recognized, the genetic similarity between some human and animal viruses makes it likely to occur. This review provides an update on the epidemiology of both classic and novel human astroviruses, and a comprehensive view on confirmed or potential association between astrovirus and human disease.
Dominguez de Maria, P., Kossmann, B., Potgrave, N., Buchholz, S., Trauthwein, H., May, O., & Gröger, H. (2005). Improved Process for the Enantioselective Hydrolysis of Prochiral Diethyl Malonates Catalyzed by Pig Liver Esterase. Synlett(11), 1746-1748. doi:10.1055/s-2005- ...
We previously developed an analytical strategy based on cladistic theory to identify subsets of haplotypes that are associated with significant phenotypic deviations. Our initial approach was limited to segments of DNA in which little recombination occurs. In such cases, a cladogram can be constructed from the restriction site data to estimate the evolutionary steps that interrelate the observed haplotypes to one another. The cladogram is then used to define a nested statistical design for identifying mutational steps associated with significant phenotypic deviations. The central assumption behind this strategy is that a mutation responsible for a particular phenotypic effect is embedded within the evolutionary history that is represented by the cladogram. The power of this approach depends on the accuracy of the cladogram in portraying the evolutionary history of the DNA region. This accuracy can be diminished both by recombination and by uncertainty in the estimated cladogram topology. In a ...
The most comprehensive review of the research in CES published to date is a chapter by Ray B. Smith, Ph.D. in the book, Neural Stimulation, published in 1985. Dr. Smith has been researching CES since 1972. He concluded, "There are 40 studies of CES readily available in the U.S. in which the dependent variable is reliable. When these are examined alone it becomes apparent that CES is effective in alleviating symptoms of anxiety, depression, and insomnia...CES appears effective as a treatment for withdrawal in the chemically dependent person...Other promising areas of treatment are in hypergastric acidity and migraine headaches." Dr. Smith adds, "CES appears to be safe, with no harm or negative side effects having been reported to date in controlled studies...Finally, while one usually assumes some placebo effect from a treatment as dramatic as this, none has been reported in studies controlled for this effect." ...
After a harrowing and uncertain journey, I successfully arrived in Vegas (without my luggage) for the 2014 edition of CES - the largest US tech trade show. While the convention center floor doesnt actually open until Tuesday, press events begin tomorrow. Not that the timing deterred me from going on a quick recon mission while awaiting my suitcase. And, as you can see above, the CES media trailers are in full effect (with Engadgets studio under construction). As to themes, 4K HDTV and wearable tech top the pre-show buzz, with a healthy dose of Audi chatter and the requisite glut of iPhone accessorizing (despite Apple, Inc not actually having a CES presence). Plus you cant walk 100′ without encountering something Samsung-branded.. CES is indeed grueling, as you may have read. But its also exhilarating. And those who dont find value are doing it wrong (and perhaps should find careers in a different industry). Like most things, the show is what you make of it - and I try to bring a healthy ...
The Consumer Electronics Association (CEA) ® is returning to France for the third annual CES Unveiled Paris this Wednesday. At more than twice the size of the 2014 event and with more than 50 exhibitors confirmed, the sold-out event will bring innovative technology companies, top press, buyers, industry analysts and key tech influencers together to highlight and review new products and tech trends originating at CES. CES Unveiled Paris will take place from 2-6 PM, on October 21, at the Pavillon Cambon-Capucines in Paris, France.
Ford has announced that the 2017 Ford GT supercar has been chosen as the official car of CES 2016. As such, the car will be on display at CES 2016 in all i...
Relonch wanted me to fall in love with photography again this CES. But its camera is so radically different from everything Ive used before that I struggled to...
Once again, the Toms Hardware team was out in force at the annual consumer electronics show in Las Vegas. Here are our top picks for CES 2016.
Kya aap bhi aapke chehre par pade red spot ko lekar pareshan hai to aaiye jante hai laal dhabbe ko hatane ke tarike jisse aap sundar dikh sakege.
Esterase D and general esterases (which use a- or J3-naphthyl acetate as substrates) were investigated electrophoretically in the paddy field fish, Trichogaster pectoralis. Variants were observed for these enzymes. It is hypothesized that esterase D phenotypes are due to two codominant alleles at an autosomal locus, and that four loci are involved in the control of the general esterases. ...
PubMed journal article Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Esterases represent an ancient family of enzymes, found across all kingdoms, which have diverged and occupied a wide range of functional niches. Because of their biochemical diversity and electrophoretic variability, esterases are widely used as genetic markers in gel electrophoresis assays, yet they remain ill-defined. The aim of this study is to characterise esterases from plants with roles in both normal cellular metabolism as well as in xenobiotic metabolism. A survey of esterase activities in four species of crop plants (Triticum aestivum, Zea mays, Glycine max and Oryza sativa) and Arabidopsis thaliana has shown that most of the esterases were typical carboxylesterases containing a catalytically active serine residue. Esterases varied considerably between plants according to their electrophoretic mobility and their substrate specificity. However, their sensitivities to inhibitors were broadly similar with serine hydrolase inhibitors, such as paraoxon, abolishing most esterolytic activify. ...
Because of the hereditary nature of retinoblastoma, it is currently recommended that all siblings and children of retinoblastoma patients be examined under anesthesia (EUA) every 2 to 4 months during the first years of life. In the future, laboratory studies including karyotyping, Southern blot analysis, Polymerase Chain Reactions (PCR), DNA sequence analysis/polymorphisms, and Esterase D reactions may eliminate the need to examine children under anesthesia. The aim of genetic screening in families with hereditary retinoblastoma is to identify those persons who carry a mutation and are at risk for tumor development. In 15 percent of families with hereditary retinoblastoma, the tumor-predisposing mutation itself can be detected using karyotyping or Southern blot analysis. When a detectable deletion is present, one can identify individuals carrying the mutation with over 99 percent accuracy. In the remaining 85 percent of families, no mutation can be found directly. However, in 95 percent of such ...
Mary Horsley continues a series about Crohns disease and extra-intestinal problems and IBD-related symptoms. Part four focuses on organs and blood.
No DirecTV booth on the show floor either and, possibly related, Im not expecting any official TiVo box announcements or TiVoShanan in Vegas. Boo. The Sands convention center attached to The Venetian which once featured a variety of up and coming vendors in smaller booths has been replaced by what looks like a smaller high-end audio area. The CEA says theres more vendors this year, but they collectively appear to be using less space. I wish CES Unveiled was the night before the show floor opens, not two nights before. Which is why Ill be skipping it this year during my shortest CES visit yet. OTHERWISE, Im very anxious to get going - see the new gear and my industry pals. Its always a blast. Even if I come home sick as a dog from sleep deprivation and excessive hand shaking.. ...
There is currently a debate concerning the definition of the taxon Tetrapoda, which is part of a wider debate dealing with the definiton of phylogenetic groups. Many papers over recent years (eg. Gauthier et al., 1989, Rowe, 1988, Rowe et al., 1992, de Queiroz et al., 1992) have suggested that a phylogenetic, or node-based, definition, is more rigorous than one which employs a key-character, with both a crown-group definition (Altangerel et al., 1993, Norell and Novacek, 1992, Norell et al., 1993, Lebedev and Coates 1995) and a total-group definition (Patterson, 1993, Coates, 1996) having its adherents. In the case of the Tetrapoda, the crown-group would encompass the clade containing all the modern representatives, namely the Amphibia and the Amniota, plus any fossil taxa falling above the node in the cladogram representing their nearest common ancestor. In that case, Tetrapoda would exclude any fossil taxon which falls outside this grouping, independent of the possession of any key ...
There is currently a debate concerning the definition of the taxon Tetrapoda, which is part of a wider debate dealing with the definiton of phylogenetic groups. Many papers over recent years (eg. Gauthier et al., 1989, Rowe, 1988, Rowe et al., 1992, de Queiroz et al., 1992) have suggested that a phylogenetic, or node-based, definition, is more rigorous than one which employs a key-character, with both a crown-group definition (Altangerel et al., 1993, Norell and Novacek, 1992, Norell et al., 1993, Lebedev and Coates 1995) and a total-group definition (Patterson, 1993, Coates, 1996) having its adherents. In the case of the Tetrapoda, the crown-group would encompass the clade containing all the modern representatives, namely the Amphibia and the Amniota, plus any fossil taxa falling above the node in the cladogram representing their nearest common ancestor. In that case, Tetrapoda would exclude any fossil taxon which falls outside this grouping, independent of the possession of any key ...
A primary culture of normal corneal epithelium was immortalized with Ad12-SV40 hybrid virus by overnight incubation with virus at 37°C
Consmer Electronics Show (CES) 2017 is only a week away, and we have a list of activities at the FLIR booth (Booth #35706) that you wont want to miss!
Today FLIR announced a competition aimed at the Maker community - gadget-making hobbyists - that will give five Makers a trip to Consumer Electronics Show (CES) 2017 in Las Vegas to pitch their projects (aka makes).
Current Research. Plasticité phénotypique et réponses adaptatives aux changements environnementaux chez les insectes. Lensemble des êtres vivants est soumis à un environnement qui varie dans le temps et dans lespace et, par conséquent, à des pressions de sélection changeantes. Cette hétérogénéité environnementale risque de saccentuer dans les prochaines années en grande partie due aux activités humaines (changement climatique, introduction despèces invasives). Les changements climatiques vont affecter en premier les espèces incapables de réguler leur température interne, notamment les insectes.. Je mintéresse aux mécanismes de réponses adaptatives à ces changements environnementaux et plus particulièrement à la plasticité phénotypique. La plasticité phénotypique est généralement définie comme la capacité dun génotype à produire différents phénotypes en fonction des conditions environnementales. La plasticité phénotypique est un phénomène ...
Cherchez-vous à regarder après télécharger Koocheh Mardha cinématographe dans épanchementcoulée !. Ça cinéma levant seul mise en liberté alors a reçu seul annotation: sein - exécution: minutes dexécution. Connectez-vous simplement sur ce lien ci-dessous ensuite choisissez selon ces catégories à acquérir cela téléchargement de intégraux ces cinéma disponibles dans seul particulier. ...
Cherchez-vous à regarder après télécharger Noobz cinématographe dans épanchementcoulée !. Ça cinéma levant seul mise en liberté alors a reçu seul annotation: 5.3 sein - exécution: 90 minutes dexécution. Connectez-vous simplement sur ce lien ci-dessous ensuite choisissez selon ces catégories à acquérir cela téléchargement de intégraux ces cinéma disponibles dans seul Comedy, Adventure particulier. ...
The European trade body for silicones has hit back against claims that the chemical family is threatened in personal care by alternatives and alleged environmental risks.
La plus grande chaîne daccessoires de cuisine au Québec! Nous vous offrons un choix de plus de 40 000 articles en magasin, des employés passionnés, les mei
LAS VEGAS (CNN) -- Judging by a preview event at this years Consumer Electronics Show, one big gadget trend this year will be sensors that track almost everything in your daily life.
Published In: Diagnoses de Cucurbitacées nouvelles et observations sur les espèces critiques ... Premier fascicule 1: 17. 1876. (Jan-Feb 1876) (Diagn. Cucurb. Nouv.) ...
Les congrès sont clés pour Nanobiotix, lors de ces évènements, la Société publie des données et des résultats scientifiques. Cette section répertorie les
Opprinnelig postet av oba .... og noen dager senere s var HD DVD igjen i ledelsen. Dette rimer d rlig med prognosene som Fox la frem p CES: http://m
Definition of antibody-directed enzyme prodrug therapy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is antibody-directed enzyme prodrug therapy? Meaning of antibody-directed enzyme prodrug therapy as a legal term. What does antibody-directed enzyme prodrug therapy mean in law?
Several fitness components in strains of Drosophila mulleri carrying the slow or the fast alleles for the major beta esterase (esterase-4) found in this species, as well as in heterozygous flies in which the slow or fast alleles came from one of the parents, were evaluated. Twelve components were analysed including longevity of both virgins and mated males and females, productivity, viability, including the egg-larva, egg-pupa, egg-imago and pupa-imago periods. These parameters were used to estimate the total fitness for each genotype. The best score was reached by individuals having the Est-4(S)/Est-4(S) genotype (scored at 1.000), followed by a fitness value of 0.892 presented by the Est-4(F)/Est-4(S) genotype (with the fast allele from maternal origin), 0.863 for the Est-4(F)/Est-4(F) and 0.842 for the Est-4(S)/Est-4(F) genotypes (with Est-4(F) maternal origin). These results suggested a higher relative adaptability of the Est-4(S)/Est-4(S) genotype followed by the Est-4(F)/Est-4(S) hybrid ...
Transferred from the ejaculatory bulbs of males to the female genitals upon copulation, plays an important role in the reproductive biology.
Guidchem offer qualified suppliers for 7-Ethyl-10-hydroxycamptothecin (CAS NO.86639-52-3) ,Find latest products of 7-Ethyl-10-hydroxycamptothecin manufacturers, suppliers, exporters and producers on guidechem.com.
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
A study into how well students understand specific diagrams reminds us that, while pictures may be worth 1000 words, even small details can make a significant difference to how informative they are.. The study focused on variously formatted cladograms (also known as phylogenetic trees) that are commonly used in high school and college biology textbooks. Such diagrams are hierarchically branching, and are typically used to show the evolutionary history of taxa.. Nineteen college students (most of whom were women), who were majoring in biology, were shown cladograms in sequential pairs and asked whether the second cladogram (a diagonal one) depicted relationships that were the same or different as those depicted in the first cladogram (a rectangular one). Taxa were represented by single letters, which were either in forward or reverse alphabetical order. Each set (diagonal and rectangular) had four variants: up to the right (UR) with forward letters; UR with reverse letters; down to the right ...
IBD News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website ...
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In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using
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CES1 carboxylesterase 1 [Homo sapiens (human)] - Gene - NCBICES1 carboxylesterase 1 [Homo sapiens (human)] - Gene - NCBI

liver carboxylesterase 1. Names. acyl coenzyme A:cholesterol acyltransferase. brain carboxylesterase hBr1. carboxylesterase 1 ( ... carboxylesterase 2 (liver). cholesteryl ester hydrolase. cocaine carboxylesterase. egasyn. human monocyte/macrophage serine ... CES1 carboxylesterase 1 [Homo sapiens] CES1 carboxylesterase 1 [Homo sapiens]. Gene ID:1066 ... Title: Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. ...
more infohttps://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1066

Proteins matched: CARBOXYLESTERASE B 1 (PS00122) | InterPro | EMBL-EBIProteins matched: CARBOXYLESTERASE B 1 (PS00122) | InterPro | EMBL-EBI

Proteins matched: CARBOXYLESTERASE_B_1 (PS00122) This signature appears in the following proteins: Showing 1 to 20 of 27967 ... Carboxylesterase patB. Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1). Loading... ...
more infohttp://www.ebi.ac.uk/interpro/signature/PS00122/proteins-matched

Carboxylesterase - WikipediaCarboxylesterase - Wikipedia

... carboxylesterase 1 carboxylesterase 2 carboxylesterase 3 esterase A, esterase B, esterase D, methylbutyrase, methylbutyrate ... In enzymology, a carboxylesterase or carboxylic-ester hydrolase (EC 3.1.1.1) is an enzyme that catalyzes a chemical reaction of ... The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a ... Humans genes that encode carboxylesterase enzymes include: CES1 CES2 CES3 CES4 CES7 CES8 An approved nomenclature has been ...
more infohttps://en.wikipedia.org/wiki/Carboxylesterase

anti-Carboxylesterase 3 Primary Antibodiesanti-Carboxylesterase 3 Primary Antibodies

carboxylesterase 2 , carboxylesterase 3 (brain) , esterase 31 , liver carboxylesterase 31 homolog , carboxylesterase 3 ... Carboxylesterase 3 (CES3) Antigen-Profil Beschreibung des Gens This gene encodes a member of the carboxylesterase large family ... anti-Carboxylesterase 3 (CES3) Antikörper. Bezeichnung:. anti-Carboxylesterase 3 Antikörper (CES3). Auf www.antikoerper-online. ... Weitere Antikörper gegen Carboxylesterase 3 Interaktionspartner. Human Carboxylesterase 3 (CES3) Interaktionspartner * This ...
more infohttps://www.antikoerper-online.de/monocarboxylic-acid-catabolic-process-pathway-92/ces3-antibody-7080/

carboxylesterase 4A Research Products: Novus Biologicalscarboxylesterase 4A Research Products: Novus Biologicals

Browse our carboxylesterase 4A product catalog backed by our Guarantee+. ... Diseases related to carboxylesterase 4A. Discover more about diseases related to carboxylesterase 4A.. Confusion. ... Bioinformatics Tool for carboxylesterase 4A. Discover related pathways, diseases and genes to carboxylesterase 4A. Need help? ... carboxylesterase 4A products available through Novus Biologicals. ...
more infohttps://www.novusbio.com/common-name/carboxylesterase-4a

Carboxylesterase 3 - WikipediaCarboxylesterase 3 - Wikipedia

Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene. Carboxylesterase 3 is a member of a large multigene ... "Entrez Gene: CES3 carboxylesterase 3 (brain)". Lee CV, Hymowitz SG, Wallweber HJ, et al. (2006). "Synthetic anti-BR3 antibodies ... Aida K, Moore R, Negishi M (1993). "Cloning and nucleotide sequence of a novel, male-predominant carboxylesterase in mouse ... and a newly expressed carboxylesterase isoenzyme, CES3". Drug Metab Dispos. 32 (5): 505-11. doi:10.1124/dmd.32.5.505. PMID ...
more infohttps://en.wikipedia.org/wiki/Carboxylesterase_3

Carboxylesterase 3 Peptides and Proteins: Novus BiologicalsCarboxylesterase 3 Peptides and Proteins: Novus Biologicals

Browse our Carboxylesterase 3 recombinant proteins backed by our 100% Guarantee. ... Carboxylesterase 3 Peptides and Proteins We offer Carboxylesterase 3/CES3/Esterase 31 Peptides and Carboxylesterase 3/CES3/ ... Carboxylesterase 3/CES3/Esterase 31 protein, CES3 protein, carboxylesterase 3 (brain) protein, carboxylesterase 3 protein, EC ... Our Carboxylesterase 3/CES3/Esterase 31 Peptides and Carboxylesterase 3/CES3/Esterase 31 Proteins can be used in a variety of ...
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The Development of Bacterial Carboxylesterase Biological Recognition Elements for Cocaine Detection | SpringerLinkThe Development of Bacterial Carboxylesterase Biological Recognition Elements for Cocaine Detection | SpringerLink

Quax, W. J., & Broekhuizen, C. P. (1994). Development of a new Bacillus carboxyl esterase for use in the resolution of chiral ... 2008). Application of carboxylesterase activity in environmental monitoring and toxicity identification protocol (TIEs). ... Redinbo, M. R., Bencharit, S., & Potter, P. M. (2003). Human carboxylesterase 1: From drug metabolism to drug discovery. ... 1997). Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of ...
more infohttps://link.springer.com/article/10.1007%2Fs12033-018-0098-z

Comparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds | SpringerLinkComparison of Cholinesterases and Carboxylesterase as Bioscavengers for Organophosphorus Compounds | SpringerLink

Maxwell D.M., Brecht K., Saxena A., Feaster S., Doctor B.P. (1998) Comparison of Cholinesterases and Carboxylesterase as ... and carboxylesterase (CaE), to provide protection against OP compounds has been demonstrated in rodents as well as nonhuman ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4899-1540-5_109

RCSB PDB - Protein Feature View 









 - Palmitoleoyl-protein carboxylesterase NOTUM - Q8R116 (NOTUM MOUSE)RCSB PDB - Protein Feature View - Palmitoleoyl-protein carboxylesterase NOTUM - Q8R116 (NOTUM MOUSE)

Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating ...
more infohttps://www.rcsb.org/pdb/protein/Q8R116

Measurement of Carboxylesterase (CES) Activities - Current ProtocolsMeasurement of Carboxylesterase (CES) Activities - Current Protocols

Measurement of Carboxylesterase (CES) Activities (Masakiyo Hosokawa, Chiba University, Chiba, Japan and Tetsuo Satoh, ... Measurement of Carboxylesterase (CES) Activities (Masakiyo Hosokawa, Chiba University, Chiba, Japan and Tetsuo Satoh, ... cDNA cloning, characterization and stable expression of novel human brain carboxylesterase. F.E.B.S. Lett. 458:17‐22. ... Differences in the induction of carboxylesterase isozymes in rat liver microsomes by perfluorinated fatty acids. Xenobiotica. ...
more infohttp://www.currentprotocols.com/WileyCDA/CPUnit/refId-tx0407.html

Carboxylesterase 2 | definition of carboxylesterase 2 by Medical dictionaryCarboxylesterase 2 | definition of carboxylesterase 2 by Medical dictionary

What is carboxylesterase 2? Meaning of carboxylesterase 2 medical term. What does carboxylesterase 2 mean? ... Looking for online definition of carboxylesterase 2 in the Medical Dictionary? carboxylesterase 2 explanation free. ... redirected from carboxylesterase 2) CES1. A gene on chromosome 16q22.2 that encodes a member of the carboxylesterase family, ... Carboxylesterase 2 , definition of carboxylesterase 2 by Medical dictionary https://medical-dictionary.thefreedictionary.com/ ...
more infohttps://medical-dictionary.thefreedictionary.com/carboxylesterase+2

Ecaj 0181 - Phospholipase/Carboxylesterase - Ehrlichia canis (strain Jake) - Ecaj 0181 gene & proteinEcaj 0181 - Phospholipase/Carboxylesterase - Ehrlichia canis (strain Jake) - Ecaj 0181 gene & protein

Phospholipase/CarboxylesteraseImported. ,p>Information which has been imported from another database using automatic procedures ... ehrcj-q3yss3 LYsophospholipase_carboxylesterase. Protocols and materials databases. Structural Biology Knowledgebase. Search... ... tr,Q3YSS3,Q3YSS3_EHRCJ Phospholipase/Carboxylesterase OS=Ehrlichia canis (strain Jake) OX=269484 GN=Ecaj_0181 PE=4 SV=1 ...
more infohttps://www.uniprot.org/uniprot/Q3YSS3

Carboxylesterase 3 ELISA & Assay KitsCarboxylesterase 3 ELISA & Assay Kits

Compare and order Carboxylesterase 3 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. ... carboxylesterase 2 , carboxylesterase 3 (brain) , esterase 31 , liver carboxylesterase 31 homolog , carboxylesterase 3 ... This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or ...
more infohttps://www.antibodies-online.com/monocarboxylic-acid-catabolic-process-pathway-92/ces3-elisa-kit-7081/

CES2F (carboxylesterase 2F) - KOMP (Knockout Mouse Project)CES2F (carboxylesterase 2F) - KOMP (Knockout Mouse Project)

carboxylesterase 2F. Synonyms: 2310038E17Rik. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are ...
more infohttps://www.komp.org/geneinfo.php?geneid=5028

Carboxylesterase Activity Assay Kit (Fluorometric) | K2014 | BioVision, Inc.Carboxylesterase Activity Assay Kit (Fluorometric) | K2014 | BioVision, Inc.

The kit uses the proprietary substrate for the quantification of Carboxylesterase (CE)... ... plate-based fluorometric assay for measuring Carboxylesterase activity in biological samples. ... BioVisions Carboxylesterase Activity Assay Kit is a simple, rapid, ... Human Carboxylesterase 1 (E.C. 3.1.1.1, CES1, hCE1, CES1b or CES1A1) is a α,β-serine hydrolase expressed in most tissues with ...
more infohttps://www.biovision.com/carboxylesterase-activity-assay-kit-fluorometric.html

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles - Edwards - 2011 - Biotechnology Progress ...Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles - Edwards - 2011 - Biotechnology Progress ...

Here, we present the silica encapsulation of human drug metabolism enzyme carboxylesterase 1 (hCE1) in the presence of a range ... Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Authors. *. Jonathan S. Edwards,. *Dept. ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/btpr.604/abstract

Active Mouse (Murine) Carboxylesterase 5A (CES5A) Protein (His tag), Recombinant | ABIN2008060Active Mouse (Murine) Carboxylesterase 5A (CES5A) Protein (His tag), Recombinant | ABIN2008060

Recombinant Carboxylesterase 5A (CES5A) Protein (His tag). Species: Mouse (Murine). Source: Human Cells. Order product ... Carboxylesterase 5A (CES5A) (Extracellular Domain), (AA 1-556) (Active) protein (... Carboxylesterase 5A (CES5A) (Extracellular ... Carboxylesterase 5A (CES5A) (Extracellular Domain), (AA 1-556) (Active) protein (His tag) Read product details ... Carboxylesterase 5A (CES5A) (Extracellular Domain), (AA 1-556) (Active) protein (His tag) Read product details ...
more infohttp://www.antibodies-online.com/protein/2008060/Carboxylesterase+5A+CES5A+Extracellular+Domain,+AA+1-556+Active+protein+His+tag/

Pharmaceutics | Free Full-Text | Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across...Pharmaceutics | Free Full-Text | Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across...

We found that carboxylesterase (CES), especially the rat CES1 isozyme, Hydrolase A, is expressed in rat skin and that the ... Keywords: prodrug; skin permeation; hydrolysis; carboxylesterase prodrug; skin permeation; hydrolysis; carboxylesterase ►▼ ... Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin. Teruko Imai * , Yuko ... We found that carboxylesterase (CES), especially the rat CES1 isozyme, Hydrolase A, is expressed in rat skin and that the ...
more infohttp://www.mdpi.com/1999-4923/5/3/371

Liver carboxylesterase elisa and antibodyLiver carboxylesterase elisa and antibody

Recombinant Protein and Liver carboxylesterase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Liver carboxylesterase. Liver carboxylesterase ELISA Kit. Liver carboxylesterase Recombinant. Liver carboxylesterase Antibody. ... Liver carboxylesterase 1. Liver carboxylesterase 1 ELISA Kit. Liver carboxylesterase 1 Recombinant. Liver carboxylesterase 1 ... Liver carboxylesterase 2. Liver carboxylesterase 2 ELISA Kit. Liver carboxylesterase 2 Recombinant. Liver carboxylesterase 2 ...
more infohttps://www.mybiosource.com/protein_family.php?root=liver-carboxylesterase

Anti-Carboxylesterase 1 / CES1 Antibody | Rabbit anti-Rat Biotin | LSBioAnti-Carboxylesterase 1 / CES1 Antibody | Rabbit anti-Rat Biotin | LSBio

CES1 antibody LS-C687036 is a biotin-conjugated rabbit polyclonal antibody to rat CES1 (Carboxylesterase 1). Validated for IHC ... CES1 antibody LS-C687036 is a biotin-conjugated rabbit polyclonal antibody to rat CES1 (Carboxylesterase 1). Validated for IHC ...
more infohttps://www.lsbio.com/antibodies/carboxylesterase-1-antibody-ces1-antibody-aa19-300-biotin-ihc-wb-western-ls-c687036/712464

Probable inactive carboxylesterase elisa and antibodyProbable inactive carboxylesterase elisa and antibody

Recombinant Protein and Probable inactive carboxylesterase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and ... Probable inactive carboxylesterase Os04g0669700. Probable inactive carboxylesterase Os04g0669700 ELISA Kit. Probable inactive ... Probable inactive carboxylesterase Os04g0669700 Antibody. Os04g0669700 ELISA Kit. Os04g0669700 Recombinant. Os04g0669700 ... Below are the list of possible Probable inactive carboxylesterase products. If you cannot find the target and/or product is not ...
more infohttps://www.mybiosource.com/protein_family.php?root=probable-inactive-carboxylesterase

A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging - Journal of Materials Chemistry B (RSC...A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging - Journal of Materials Chemistry B (RSC...

... synthesized and applied for the highly selective and sensitive fluorescence sensing of carboxylesterase in live cells, sera and ... Upon addition of carboxylesterase, the latent probe could be easily hydrolyzed to liberate the fluorophore hydroxy hemicyanine ... A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging H. Zhou, J. Tang, J. Zhang, B. Chen, J ... The newly developed probe was successfully used to monitor and image carboxylesterase activity in complex biological samples ...
more infohttps://pubs.rsc.org/en/content/articlelanding/2019/tb/c9tb00310j

Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum | Drug Metabolism & DispositionIntestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum | Drug Metabolism & Disposition

Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum. Kenji Masaki, Mitsuru Hashimoto and Teruko Imai ... Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum. Kenji Masaki, Mitsuru Hashimoto and Teruko Imai ... Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum. Kenji Masaki, Mitsuru Hashimoto and Teruko Imai ... Intestinal First-Pass Metabolism via Carboxylesterase in Rat Jejunum and Ileum Message Subject (Your Name) has forwarded a page ...
more infohttp://dmd.aspetjournals.org/content/35/7/1089/tab-figures-data
  • Auf www.antikoerper-online.de finden Sie aktuell 34 Carboxylesterase 3 (CES3) Antikörper von 12 unterschiedlichen Herstellern. (antikoerper-online.de)
  • Each Carboxylesterase 3/CES3/Esterase 31 Peptide and Carboxylesterase 3/CES3/Esterase 31 Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Carboxylesterase 3 is an enzyme that in humans is encoded by the CES3 gene. (wikipedia.org)
  • Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody-drug conjugates (ADCs) in mouse, but not in monkey or human. (aacrjournals.org)
  • Conclusion 123 I-iomazenil whole-body imaging has good possibility of direct measurement of hepatic carboxylesterase activity as accumulation of 123 I-R-COOH in the gall bladder through bile and in the bladder through urine. (ovid.com)
  • Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression. (sigmaaldrich.com)
  • Results From the in-vitro metabolism of 123 I-iomazenil using BNPP, the enzyme converting 123 I-iomazenil to 123 I-R-COOH was identified as carboxylesterase, and that converting 123 I-iomazenil to M2 was identified as cytochrome P450 in experiments with and without an NADPH generator. (ovid.com)
  • The newly developed probe was successfully used to monitor and image carboxylesterase activity in complex biological samples such as serum, live cells and tissues. (rsc.org)
  • Upon addition of carboxylesterase, the latent probe could be easily hydrolyzed to liberate the fluorophore hydroxy hemicyanine and emit the off-on spectroscopic signal, which is desirable for obtaining sensitive detection with high specificity. (rsc.org)
  • Below are the list of possible Probable inactive carboxylesterase products. (mybiosource.com)
  • In the present study, we found that recombinant carboxylesterase (CES) 2 could hydrolyze flutamide at low concentrations of flutamide. (aspetjournals.org)
  • In this study, a new red lysosome-targeted fluorescence off-on probe has been rationally designed, synthesized and applied for the highly selective and sensitive fluorescence sensing of carboxylesterase in live cells, sera and tissues. (rsc.org)
  • Zusätzlich bieten wir Ihnen Carboxylesterase 3 Proteine (6) und Carboxylesterase 3 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)