OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Ornithine CarbamoyltransferaseOrnithine Carbamoyltransferase Deficiency DiseaseCarboxyl and Carbamoyl TransferasesCarbamyl PhosphateCarbamoyl-Phosphate Synthase (Ammonia)Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)TransferasesAspartate CarbamoyltransferaseCarbamatesGlutathione TransferaseOrnithineAlkyl and Aryl TransferasesPhosphotransferases (Carboxyl Group Acceptor)Molecular Sequence DataTransferases (Other Substituted Phosphate Groups)Carbon-Nitrogen LigasesAmino Acid SequenceKineticsAmmoniaCitrullineOrotic AcidDNA NucleotidylexotransferaseEscherichia coliAzauridineCoenzyme A-TransferasesLigasesDogfishBinding SitesSubstrate SpecificityPhosphonoacetic AcidGlutamineDihydroorotaseUridine MonophosphateAspartic AcidUreaNucleic AcidsRNA NucleotidyltransferasesGene LibraryHarmineLibraries, MedicalOligonucleotidesBallistocardiographyLinear Energy TransferTropherymaWhipple DiseaseActinobacteriaActinomycetales InfectionsCentral Nervous System Bacterial InfectionsActinomycetalesLegionnaires' DiseaseClostridium thermocellumRenewable EnergyBiofuelsClostridiumCellulaseGram-Positive Asporogenous Rods, IrregularMetabolic Networks and Pathways
Ornithine Carbamoyltransferase
A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
Ornithine Carbamoyltransferase Deficiency Disease
An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)
Carboxyl and Carbamoyl Transferases
A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.
Carbamyl Phosphate
The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
Carbamoyl-Phosphate Synthase (Ammonia)
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
Transferases
Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.
Aspartate Carbamoyltransferase
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
Carbamates
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Glutathione Transferase
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Ornithine
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
Alkyl and Aryl Transferases
A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.
Phosphotransferases (Carboxyl Group Acceptor)
A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Transferases (Other Substituted Phosphate Groups)
A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.
Carbon-Nitrogen Ligases
Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Kinetics
The rate dynamics in chemical or physical systems.
Ammonia
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Citrulline
Orotic Acid
DNA Nucleotidylexotransferase
A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Azauridine
A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.
Coenzyme A-Transferases
Enzymes which transfer coenzyme A moieties from acyl- or acetyl-CoA to various carboxylic acceptors forming a thiol ester. Enzymes in this group are instrumental in ketone body metabolism and utilization of acetoacetate in mitochondria. EC 2.8.3.
Ligases
A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.
Dogfish
Sharks of the family Squalidae, also called dogfish sharks. They comprise at least eight genera and 44 species. Their LIVER is valued for its oil and its flesh is often made into fertilizer.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Phosphonoacetic Acid
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
Glutamine
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
Dihydroorotase
An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Uridine Monophosphate
5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.
Aspartic Acid
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Urea
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Nucleic Acids
High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.
RNA Nucleotidyltransferases
Enzymes that catalyze the template-directed incorporation of ribonucleotides into an RNA chain. EC 2.7.7.-.
Gene Library
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Harmine
Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.
Libraries, Medical
Oligonucleotides
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
Ballistocardiography
Technique of graphic representation of the movements of the body imparted by the ballistic forces (recoil and impact) associated with cardiac contraction and ejection of blood and with the deceleration of blood flow through the large blood vessels. These movements, quantitatively very minute, are translated by a pickup device (transducer) into an electrical potential which is suitably amplified and recorded on a conventional electrocardiograph or other recording machine.
Linear Energy Transfer
Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T).
Tropheryma
A genus of gram-positive bacteria in the family Cellulomonadaceae.
Whipple Disease
A chronic systemic infection by a gram-positive bacterium, Tropheryma whippelii, mainly affecting the SMALL INTESTINE but also the JOINTS; CARDIOVASCULAR SYSTEM; and the CENTRAL NERVOUS SYSTEM. The disease is characterized by fat deposits in the INTESTINAL MUCOSA and LYMPH NODES, malabsorption, DIARRHEA with fatty stools, MALNUTRITION, and ARTHRITIS.
Actinobacteria
Class of BACTERIA with diverse morphological properties. Strains of Actinobacteria show greater than 80% 16S rDNA/rRNA sequence similarity among each other and also the presence of certain signature nucleotides. (Stackebrandt E. et al, Int. J. Syst. Bacteriol. (1997) 47:479-491)
Actinomycetales Infections
Infections with bacteria of the order ACTINOMYCETALES.
Central Nervous System Bacterial Infections
Bacterial infections of the brain, spinal cord, and meninges, including infections involving the perimeningeal spaces.
Actinomycetales
An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.
Legionnaires' Disease
An acute, sometimes fatal, pneumonia-like bacterial infection characterized by high fever, malaise, muscle aches, respiratory disorders and headache. It is named for an outbreak at the 1976 Philadelphia convention of the American Legion.
Clostridium thermocellum
A species of gram-positive, thermophilic, cellulolytic bacteria in the family Clostridaceae. It degrades and ferments CELLOBIOSE and CELLULOSE to ETHANOL in the CELLULOSOME.
Renewable Energy
Forms of energy that are constantly and rapidly renewed by natural processes such as solar, ocean wave, and wind energy. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Biofuels
Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).
Clostridium
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Cellulase
An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.
Gram-Positive Asporogenous Rods, Irregular
A group of irregular rod-shaped bacteria that stain gram-positive and do not produce endospores.
Metabolic Networks and Pathways
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.

Light-dependent changes in redox status of the plastidic acetyl-CoA carboxylase and its regulatory component. (1/77)

Plastidic acetyl-CoA carboxylase (ACCase; EC 6.4.1.2), which catalyses the synthesis of malonyl-CoA and is the regulatory enzyme of fatty acid synthesis, is activated by light, presumably under redox regulation. To obtain evidence of redox regulation in vivo, the activity of ACCase was examined in pea chloroplasts isolated from plants kept in darkness (dark-ACCase) or after exposure to light for 1 h (light-ACCase) in the presence or absence of a thiol-reducing agent, dithiothreitol (DTT). The protein level was similar for light-ACCase and dark-ACCase, but the activity of light-ACCase in the absence of DTT was approx. 3-fold that of dark-ACCase. The light-ACCase and dark-ACCase were activated approx. 2-fold and 6-fold by DTT respectively, indicating that light-ACCase was in a much more reduced, active form than the dark-ACCase. This is the first demonstration of the light-dependent reduction of ACCase in vivo. Measurement of the activities of ACCase, carboxyltransferase and biotin carboxylase in the presence and absence of DTT, and the thiol-oxidizing agent, 5, 5'-dithiobis-(2-nitrobenzoic) acid, revealed that the carboxyltransferase reaction, but not the biotin carboxylase reaction, was redox-regulated. The cysteine residue(s) responsible for redox regulation probably reside on the carboxyltransferase component. Measurement of the pH dependence of biotin carboxylase and carboxyltransferase activities in the ACCase suggested that both components affect the activity of ACCase in vivo at a physiological pH range. These results suggest that the activation of ACCase by light is caused partly by the pH-dependent activation of two components and by the reductive activation of carboxyltransferase.  (+info)

The biotin domain peptide from the biotin carboxyl carrier protein of Escherichia coli acetyl-CoA carboxylase causes a marked increase in the catalytic efficiency of biotin carboxylase and carboxyltransferase relative to free biotin. (2/77)

Acetyl-CoA carboxylase catalyzes the first committed step in the biosynthesis of long-chain fatty acids. The Escherichia coli form of the enzyme consists of a biotin carboxylase activity, a biotin carboxyl carrier protein, and a carboxyltransferase activity. The C-terminal 87 amino acids of the biotin carboxyl carrier protein (BCCP87) form a domain that can be independently expressed, biotinylated, and purified (Chapman-Smith, A., Turner, D. L., Cronan, J. E., Morris, T. W., and Wallace, J. C. (1994) Biochem. J. 302, 881-887). The ability of the biotinylated form of this 87-residue protein (holoBCCP87) to act as a substrate for biotin carboxylase and carboxyltransferase was assessed and compared with the results with free biotin. In the case of biotin carboxylase holoBCCP87 was an excellent substrate with a K(m) of 0.16 +/- 0.05 mM and V(max) of 1000.8 +/- 182.0 min(-1). The V/K or catalytic efficiency of biotin carboxylase with holoBCCP87 as substrate was 8000-fold greater than with biotin as substrate. Stimulation of the ATP synthesis reaction of biotin carboxylase where carbamyl phosphate reacted with ADP by holoBCCP87 was 5-fold greater than with an equivalent amount of biotin. The interaction of holoBCCP87 with carboxyltransferase was characterized in the reverse direction where malonyl-CoA reacted with holoBCCP87 to form acetyl-CoA and carboxyholoBCCP87. The K(m) for holoBCCP87 was 0.45 +/- 0.07 mM while the V(max) was 2031.8 +/- 231.0 min(-1). The V/K or catalytic efficiency of carboxyltransferase with holoBCCP87 as substrate is 2000-fold greater than with biotin as substrate.  (+info)

Herbicide sensitivity determinant of wheat plastid acetyl-CoA carboxylase is located in a 400-amino acid fragment of the carboxyltransferase domain. (3/77)

A series of chimeral genes, consisting of the yeast GAL10 promoter, yeast ACC1 leader, wheat acetyl-CoA carboxylase (ACCase; EC 6.4.1.2) cDNA, and yeast ACC1 3'-tail, was used to complement a yeast ACC1 mutation. These genes encode a full-length plastid enzyme, with and without the putative chloroplast transit peptide, as well as five chimeric cytosolic/plastid proteins. Four of the genes, all containing at least half of the wheat cytosolic ACCase coding region at the 5'-end, complement the yeast mutation. Aryloxyphenoxypropionate and cyclohexanedione herbicides, at concentrations below 10 microM, inhibit the growth of haploid yeast strains that express two of the chimeric ACCases. This inhibition resembles the inhibition of wheat plastid ACCase observed in vitro and in vivo. The differential response to herbicides localizes the sensitivity determinant to the third quarter of the multidomain plastid ACCase. Sequence comparisons of different multidomain and multisubunit ACCases suggest that this region includes part of the carboxyltransferase domain, and therefore that the carboxyltransferase activity of ACCase (second half-reaction) is the target of the inhibitors. The highly sensitive yeast gene-replacement strains described here provide a convenient system to study herbicide interaction with the enzyme and a powerful screening system for new inhibitors.  (+info)

Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). (4/77)

Two genes, accA1 and accA2, with nearly identical nucleotide sequences were cloned from Streptomyces coelicolor A3(2). The deduced amino acid sequences of the product of these two genes showed high similarity to BcpA2 of Saccharopolyspora erythraea and other biotin-containing proteins from different organisms assumed to be the alpha subunit of a propionyl-CoA carboxylase. A gene, pccB, encoding the carboxyl transferase subunit of this enzyme complex was also characterized. Strains disrupted in accA1 did not show any change in acetyl- or propionyl-CoA carboxylase activity, whilst cell-free extracts of a pccB mutant strain contained a reduced level of propionyl-CoA carboxylase. No mutants in accA2 could be isolated, suggesting that the gene may be essential. Heterologous expression of accA1, accA2 and pccB in Escherichia col and in vitro reconstitution of enzyme activity confirmed that PccB is the beta subunit of a propionyl-CoA carboxylase and that either AccA1 or AccA2 could act as the alpha component of this enzyme complex. The fact that accA2 mutants appear to be inviable suggests that this gene encodes a biotinylated protein that might be shared with other carboxyl transferases essential for the growth of S. coelicolor.  (+info)

Metabolic biotinylation of recombinant proteins in mammalian cells and in mice. (5/77)

The avidin-biotin system is a fundamental technology in biomedicine for immunolocalization, imaging, nucleic acid blotting, and protein labeling. While this technology is robust, it is limited by the fact that mammalian proteins must be expressed and purified prior to chemical biotinylation using cross-linking agents which modify proteins at random locations to heterogeneous levels and can inactivate protein function. To circumvent this limitation, we demonstrate the ability to metabolically biotinylate tagged proteins in mammalian cells and in mice using the endogenous biotinylation enzymes of the host. Endogenously biotinylated proteins were readily purified from mammalian cells using monomeric avidin and eluted under nondenaturing conditions using only biotin as the releasing agent. This technology should allow recombinant proteins and fragile protein complexes to be produced and purified from mammalian cells as well as from transgenic plants and animals. In addition, this technology may be particularly useful for cell-targeting applications in which proteins or viral gene therapy vectors can be biotinylated at genetically defined sites for combination with other targeting moieties complexed with avidin.  (+info)

Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus. (6/77)

We have cloned a DNA fragment from a genomic library of Myxococcus xanthus using an oligonucleotide probe representing conserved regions of biotin carboxylase subunits of acetyl coenzyme A (acetyl-CoA) carboxylases. The fragment contained two open reading frames (ORF1 and ORF2), designated the accB and accA genes, capable of encoding a 538-amino-acid protein of 58.1 kDa and a 573-amino-acid protein of 61.5 kDa, respectively. The protein (AccA) encoded by the accA gene was strikingly similar to biotin carboxylase subunits of acetyl-CoA and propionyl-CoA carboxylases and of pyruvate carboxylase. The putative motifs for ATP binding, CO(2) fixation, and biotin binding were found in AccA. The accB gene was located upstream of the accA gene, and they formed a two-gene operon. The protein (AccB) encoded by the accB gene showed high degrees of sequence similarity with carboxyltransferase subunits of acetyl-CoA and propionyl-CoA carboxylases and of methylmalonyl-CoA decarboxylase. Carboxybiotin-binding and acyl-CoA-binding domains, which are conserved in several carboxyltransferase subunits of acyl-CoA carboxylases, were found in AccB. An accA disruption mutant showed a reduced growth rate and reduced acetyl-CoA carboxylase activity compared with the wild-type strain. Western blot analysis indicated that the product of the accA gene was a biotinylated protein that was expressed during the exponential growth phase. Based on these results, we propose that this M. xanthus acetyl-CoA carboxylase consists of two subunits, which are encoded by the accB and accA genes, and occupies a position between prokaryotic and eukaryotic acetyl-CoA carboxylases in terms of evolution.  (+info)

An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors. (7/77)

cDNA fragments encoding the carboxyltransferase domain of the multidomain plastid acetyl-CoA carboxylase (ACCase) from herbicide-resistant maize and from herbicide-sensitive and herbicide-resistant Lolium rigidum were cloned and sequenced. A Leu residue was found in ACCases from herbicide-resistant plants at a position occupied by Ile in all ACCases from sensitive grasses studied so far. Leu is present at the equivalent position in herbicide-resistant ACCases from other eukaryotes. Chimeric ACCases containing a 1000-aa fragment of two ACCase isozymes found in a herbicide-resistant maize were expressed in a yeast ACC1 null mutant to test herbicide sensitivity of the enzyme in vivo and in vitro. One of the enzymes was resistant/tolerant, and one was sensitive to haloxyfop and sethoxydim, rendering the gene-replacement yeast strains resistant and sensitive to these compounds, respectively. The sensitive enzyme has an Ile residue, and the resistant one has a Leu residue at the putative herbicide-binding site. Additionally, a single Ile to Leu replacement at an equivalent position changes the wheat plastid ACCase from sensitive to resistant. The effect of the opposite substitution, Leu to Ile, makes Toxoplasma gondii apicoplast ACCase resistant to haloxyfop and clodinafop. In this case, inhibition of the carboxyltransferase activity of ACCase (second half-reaction) of a large fragment of the Toxoplasma enzyme expressed in Escherichia coli was tested. The critical amino acid residue is located close to a highly conserved motif of the carboxyltransferase domain, which is probably a part of the enzyme active site, providing the basis for the activity of fop and dim herbicides.  (+info)

Motility of single one-headed kinesin molecules along microtubules. (8/77)

The motility of single one-headed kinesin molecules (K351 and K340), which were truncated fragments of Drosophila two-headed kinesin, has been tested using total internal reflection fluorescence microscopy. One-headed kinesin fragments moved continuously along the microtubules. The maximum distance traveled until the fragments dissociated from the microtubules for both K351 and K340 was approximately 600 nm. This value is considerably larger than the space resolution of the measurement system (SD approximately 30 nm). Although the movements of the fragments fluctuated in forward and backward directions, statistical analysis showed that the average movements for both K340 and K351 were toward the plus end of the microtubules, i.e., forward direction. When BDTC (a 1.3-S subunit of Propionibacterium shermanii transcarboxylase, which binds weakly to a microtubule), was fused to the tail (C-terminus) of K351, its movement was enhanced, smooth, and unidirectional, similar to that of the two-headed kinesin fragment, K411. However, the travel distance and velocity of K351BDTC molecules were approximately 3-fold smaller than that of K411. These observations suggest that a single kinesin head has basal motility, but coordination between the two heads is necessary for stabilizing the basal motility for the normal level of kinesin processivity.  (+info)

Inhibition and nucleic acid binding studies of the carboxyltransferase by Brian BensonInhibition and nucleic acid binding studies of the carboxyltransferase by Brian Benson
Acetyl-CoA carboxylase is an essential enzyme, as it catalyzes the first committed and regulated step in fatty-acid biosynthesis in all organisms excepting few Archaea and Eubacteria. Acetyl-CoA carboxylase from gram-negative and gram-positive bacteria is a multifunctional enzyme composed of three separate proteins. The carboxyltransferase subunit catalyzes the transfer of a carboxyl group from carboxybiotin to acetyl-CoA, forming malonyl-CoA. The crystal structure of the Escherichia coli (E. coli) carboxyltransferase component of acetyl-CoA carboxylase revealed a unique Zn-domain, presumed to mediate nucleic acid binding, that is absent in the eukaryotic enzyme. Notably, the Zn-domain, adjacent to the active site of carboxyltransferase, makes for a unique target in the development of novel antibiotics capable of highly specific binding. Utilizing an Electrophoretic Mobility Shift Assay as part of this study, we investigated the nonspecific nucleic-acid binding and substrate (malonyl-CoA and biocytin)
https://digitalcommons.lsu.edu/gradschool_dissertations/3117/
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http://www.rostliny.net/eshopkoupit.php?rID=0&eID=10&iID=61526
Novan (NOVN) Sets New 52-Week Low at $3.40 - Watch List NewsNovan (NOVN) Sets New 52-Week Low at $3.40 - Watch List News
Novan Inc (NASDAQ:NOVN)s share price hit a new 52-week low during trading on Friday . The company traded as low as $3.40 and last traded at $4.24, with a volume of 19900 shares. The stock had previously closed at $4.30. NOVN has been the subject of a number of recent research reports. ValuEngine raised shares […]
https://www.watchlistnews.com/novan-novn-sets-new-52-week-low-at-3-40/1797689.html
How to Form a Corporation in Florida | NoloHow to Form a Corporation in Florida | Nolo
Learn about the forms and procedures needed to incorporate in Florida with this step-by-step guide. Find out how you can form a corporation online with Nolo.
https://www.nolo.com/legal-encyclopedia/how-form-corporation-florida.html
Nursing Home Abuse | Nolo.comNursing Home Abuse | Nolo.com
|p|Its an unfortunate fact that a small percentage of nursing home residents suffer avoidable injuries because of a care facilitys negligence. And in some situations, a care facility employees carelessness or intentional actions can rise to the level of abuse. Whether a nursing home resident is harmed as a result of an accident, or by conduct that might also qualify as a crime, a civil lawsuit is always on the table as a potential legal remedy. In this section, well touch on some of the key practical and legal issues that arise in cases like these.          |/p|
https://www.nolo.com/legal-encyclopedia/nursing-home-abuse
What is a quit claim deed form? | Reference.comWhat is a quit claim deed form? | Reference.com
A quit claim deed or deed form allows for the transfer of property from one individual to another without any guarantee as to the transferring persons interest, according to Nolo. It transfers...
https://www.reference.com/government-politics/quit-claim-deed-form-67913b419cf34f6f
Citrónovník pravý - WikipédiaCitrónovník pravý - Wikipédia
Citrónovník pravý, staršie Citrónovník limonový (Citrus limon) je druh malého subtropického vždyzeleného stromu z čeľade rutovité. Jeho žltý plod sa nazýva citrón. Má jednoduché vajcovité listy (dlhé 8 až 14 cm), ktoré obsahujú aromatické oleje. Kvitne od apríla do mája.[1] Malé, obojpohlavné biele kvety sú vo zväzkoch a sú veľmi voňavé. Plod je bobuľa s kožovitou šupkou (hesperídium).[2] Dorastá do výšky 3 až 6 m a má ostré tŕne[3]. Pôvodom je pravdepodobne zo severozápadnej Indie[4], rastie v Stredomorí, Juhozápadnej Ázii a na juhu Severnej Ameriky. Genetická štúdia naznačuje, že ide o kríženca medzi Citrus aurantium a Citrus medica.[5][6] Bol introdukovaný do Talianska v 2. storočí pred Kr. a v Iraku a Egypte sa pestoval v 7. storočí pred Kr.[7] Plody sa používajú na konzumáciu, ako liečivá rastlina, na čistenie (šťava, dreň aj šupka).[7] Šťava z citróna obsahuje 5% až 6% kyseliny citrónovej, s pH približne 2,2. ...
https://sk.wikipedia.org/wiki/Citr%C3%B3novn%C3%ADk_prav%C3%BD
Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro | IRIS Università degli Studi di...Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro | IRIS Università degli Studi di...
Although human transthyretin (TTR) is associated with systemic amyloidoses, an anti-amyloidogenic effect that prevents Aβ fibril formation in vitro and in animalmodels has been observed. Herewe studied the ability of three different types of TTR, namely human tetramers (hTTR),mouse tetramers (muTTR) and an engineered monomer of the human protein (M-TTR), to suppress the toxicity of oligomers formed by two different amyloidogenic peptides/proteins (HypF-N and Aβ42). muTTR is the most stable homotetramer, hTTR can dissociate into partially unfolded monomers, whereas M-TTR maintains a monomeric state. Preformed toxic HypF-N and Aβ42 oligomers were incubated in the presence of each TTR then added to cell culture media. hTTR, and to a greater extent MTTR, were found to protect human neuroblastoma cells and rat primary neurons against oligomer-induced toxicity, whereas muTTR had no protective effect. The thioflavin T assay and site-directed labeling experiments using pyrene ruled out disaggregation ...
https://flore.unifi.it/handle/2158/821884
accA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Helicobacter pylori FD506 - accA gene & proteinaccA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha - Helicobacter pylori FD506 - accA gene & protein
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
http://www.uniprot.org/uniprot/T5CLE2
I Corinthios 10 VULGATE - nolo enim vos ignorare fratres quoniam - Bible GatewayI Corinthios 10 VULGATE - nolo enim vos ignorare fratres quoniam - Bible Gateway
nolo enim vos ignorare fratres quoniam patres nostri omnes sub nube fuerunt et omnes mare transierunt et omnes in Mose baptizati sunt in nube et in
https://www.biblegateway.com/passage/?search=I+Corinthios+10&version=VULGATE&resource_type=sermon
3765. Misbranding of dextro-amphetamine sulfate tablets. U. S v. Frank A. Ponzo (Ponzos Drug Store). Plea of nolo contendere....3765. Misbranding of dextro-amphetamine sulfate tablets. U. S v. Frank A. Ponzo (Ponzos Drug Store). Plea of nolo contendere....
3765. Misbranding of dextro-amphetamine sulfate tablets. U. S v. Frank A. Ponzo (Ponzos Drug Store). Plea of nolo contendere. Fine, $300 ...
https://fdanj.nlm.nih.gov/catalog/ddnj03765
accD3 - Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta - Mycobacterium tuberculosis (strain ATCC...accD3 - Putative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta - Mycobacterium tuberculosis (strain ATCC...
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
https://www.uniprot.org/uniprot/P9WQH9
Novartis (NOVN) Given a CHF 90 Price Target at Deutsche Bank - StockNewsTimesNovartis (NOVN) Given a CHF 90 Price Target at Deutsche Bank - StockNewsTimes
Novartis (VTX:NOVN) has been given a CHF 90 price objective by equities research analysts at Deutsche Bank in a research note issued on Monday. The firm presently has a
https://stocknewstimes.com/2018/01/15/novartis-novn-given-a-chf-90-price-target-at-deutsche-bank.html
NOLO Brings VR Motion Tracking To Smartphones - Science & Technology World WebsiteNOLO Brings VR Motion Tracking To Smartphones - Science & Technology World Website
Designed to inject a whole lot more power into any existing smartphone-based VR product, the system adds room-scale tracking with six degrees of freedom, along with a pair of controllers.
http://en.twwtn.com/detail_109940.htm
200ug-Anti-Ornithine Carbamoyl Transferase (OCT)-polyclonal Antibody | Technique alternative | 01015884261 - Amoy Tope200ug-Anti-Ornithine Carbamoyl Transferase (OCT)-polyclonal Antibody | Technique alternative | 01015884261 - Amoy Tope
Order 200ug-Anti-Ornithine Carbamoyl Transferase OCT -polyclonal Antibody 01015884261 at Gentaur 200ug Ornithine Carbamoyl Transferase (OCT)
https://amoytope.com/catalog/27476-cloud-clone-corp/28600-200ug-antibody-to-ornithine-carbamoyl-transferase-oct-polyclonal-antibody-to
3001. Misbranding of amphetamine hydrochloride tablets. U. S. v. Charles R. Wirth (Wirth Drug Store). Plea of nolo contendere....3001. Misbranding of amphetamine hydrochloride tablets. U. S. v. Charles R. Wirth (Wirth Drug Store). Plea of nolo contendere....
3001. Misbranding of amphetamine hydrochloride tablets. U. S. v. Charles R. Wirth (Wirth Drug Store). Plea of nolo contendere. Fine, $300; defendant placed on probation for 1 year ...
https://fdanj.nlm.nih.gov/catalog/ddnj03001
Novartis (NOVN) Given a CHF 92 Price Target by Morgan Stanley Analysts - Community Financial NewsNovartis (NOVN) Given a CHF 92 Price Target by Morgan Stanley Analysts - Community Financial News
Novartis (VTX:NOVN) has been given a CHF 92 price target by analysts at Morgan Stanley in a report issued on Friday. The firm presently has a
https://www.com-unik.info/2017/12/01/novartis-novn-given-a-chf-92-price-target-by-morgan-stanley-analysts.html
Ask the Contractor: All about grasshoppers | The Daily Courier | Prescott, AZAsk the Contractor: All about grasshoppers | The Daily Courier | Prescott, AZ
Thanks for your phone calls and emails about my fruit files gone wild column. I am so happy to know that I am not the only one that was made buggy by these critters. I received several questions about we have grasshoppers how do we get rid of them?. As we know, grasshoppers are occasional pests of ornamental landscapes and this is the season. They are hopping all over in large grass fields and along uncleared roadways and in urban fringe areas. Homeowners can minimize their impact through the use of Nolo Grasshopper Bait™ which is an EPA registered biological control for grasshoppers. Nolo Bait™ contains naturally occurring Nosema locustae spores. These spores are uniformly applied to flaky wheat bran at a rate of at least 1 billion spores per pound of bran which is the bait. The bran is consumed by the grasshoppers and they become infected with the spores. The progression and persistence of this organism provides long-term benefit to the landowner without environmental damage. Nolo ...
https://www.dcourier.com/news/2016/oct/14/ask-contractor-all-about-grasshoppers/
RCSB PDB for 1A6XRCSB PDB for 1A6X
1A6X: Structure of the carboxy-terminal fragment of the apo-biotin carboxyl carrier subunit of Escherichia coli acetyl-CoA carboxylase.
http://www.rcsb.org/pdb/explore/biologyAndChemistry.do?structureId=1A6X
Metabolic engineering of microorganisms for the production of L-arginine and its derivatives | Microbial Cell Factories | Full...Metabolic engineering of microorganisms for the production of L-arginine and its derivatives | Microbial Cell Factories | Full...
In the linear pathway (Figure 1A), GLU is converted to acetylglutamate (Ac-GLU) by N-acetylglutamate synthase (NAGS, encoded by argA) which is inhibited by ARG through negative feedback regulation [36],[39]. Sequential catalytic reactions catalyzed by the next three enzymes, N-acetylglutamate kinase (NAGK, encoded by argB), N-acetylglutamate semialdehyde dehydrogenase (encoded by argC) and N-acetylornithine transaminase (encoded by argD), which are common in the three pathways (Figure 1), yield N-acetylornithine (Ac-ORN) [34]. The next step, which distinguishes the linear pathway from the other two pathways, is deacetylation of Ac-ORN by AOase to yield ORN [40],[41]. The next and final steps are carried out by ornithine carbamoyltransferase (OTC or OTCase, encoded by argF), argininosuccinate synthase (encoded by argG) and argininosuccinate lyase (encoded by argH), which finally yield ARG [35]. This pathway has been found in a few species such as Myxococcus xanthus [41] and E. coli [36].. In many ...
https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-014-0166-4
Mechanistic studies of agmatine deiminase from multiple bacterial spec by Justin E. Jones, Christina J. Dreyton et al.Mechanistic studies of agmatine deiminase from multiple bacterial spec by Justin E. Jones, Christina J. Dreyton et al.
One subfamily of guanidino group-modifying enzymes (GMEs) consists of the agmatine deiminases (AgDs). These enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia. In plants, viruses, and bacteria, these enzymes are thought to be involved in energy production, biosynthesis of polyamines, and biofilm formation. In particular, we are interested in the role that this enzyme plays in pathogenic bacteria. Previously, we reported the initial kinetic characterization of the agmatine deiminase from Helicobacter pylori and described the synthesis and characterization the two most potent AgD inactivators. Herein, we have expanded our initial efforts to characterize the catalytic mechanisms of AgD from H. pylori as well as Streptococcus mutans and Porphyromonas gingivalis. Through the use of pH rate profiles, pK(a) measurements of the active site cysteine, solvent isotope effects, and solvent viscosity effects, we have determined that the AgDs, like PADs 1 and 4
https://escholarship.umassmed.edu/thompson/56/
Sipsey Street Irregulars: Sipsey Street Exclusive: Mike Vanderboegh and David Codrea file ethics complaint on Eric Holder with...Sipsey Street Irregulars: Sipsey Street Exclusive: Mike Vanderboegh and David Codrea file ethics complaint on Eric Holder with...
a) Notification. If an attorney is found guilty of a crime or pleads guilty or nolo contendere to a criminal charge in a District of Columbia court, the clerk of that court shall, within ten days from the date of such finding or plea, transmit to this Court and to Bar Counsel a certified copy of the court record or docket entry of the finding or plea. Bar Counsel shall forward the certified copy to the Board. Upon learning that the certified copy has not been timely transmitted by the clerk of the court in which the finding or plea was made, or that an attorney has been found guilty of a crime or has pleaded guilty or nolo contendere to a criminal charge in a court outside the District of Columbia or in any federal court, Bar Counsel shall promptly obtain a certified copy of the court record or docket entry of the finding or plea and transmit it to this Court and to the Board. The attorney shall also file with this Court and the Board, within ten days from the date of such finding or plea, a ...
https://sipseystreetirregulars.blogspot.com/2012/07/sipsey-street-exclusive-mike.html?showComment=1341516125381
Biotin Carboxyl Carrier Protein - Rediff PagesBiotin Carboxyl Carrier Protein - Rediff Pages
Biotin Carboxyl Carrier Protein is on Rediff pages, ,Follow Biotin Carboxyl Carrier Protein to get latest updates from Biotin Carboxyl Carrier Protein
http://pages.rediff.com/biotin-carboxyl-carrier-protein/974593
Complex formation and regulation of Escherichia coli acetyl-CoA carbox by Tyler Craig BroussardComplex formation and regulation of Escherichia coli acetyl-CoA carbox by Tyler Craig Broussard
Acetyl-CoA carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase, biotinylated biotin carboxyl carrier protein (BCCP), and an α2β2 heterotetrameric carboxyltransferase. Catalysis by acetyl-CoA carboxylase proceeds via two half-reactions. In the first half-reaction, biotin carboxylase catalyzes the ATP-dependent carboxylation of biotin, which is covalently attached to BCCP, to form carboxybiotin. In the second half-reaction, carboxyltransferase transfers the carboxyl group from carboxybiotin to acetyl-CoA to form malonyl-CoA. All biotin-dependent carboxylases are proposed to have a two-site ping-pong mechanism where the carboxylase and transferase activities are separate and do not interact. This posits two hypotheses: either biotin carboxylase and BCCP undergo the first half-reaction, BCCP dissociates, and then BCCP interacts with carboxyltransferase to
https://digitalcommons.lsu.edu/gradschool_dissertations/2741/
Molecules | Free Full-Text | Computational Redesign of Bacterial Biotin Carboxylase Inhibitors Using Structure-Based Virtual...Molecules | Free Full-Text | Computational Redesign of Bacterial Biotin Carboxylase Inhibitors Using Structure-Based Virtual...
As the spread of antibiotic resistant bacteria steadily increases, there is an urgent need for new antibacterial agents. Because fatty acid synthesis is only used for membrane biogenesis in bacteria, the enzymes in this pathway are attractive targets for antibacterial agent development. Acetyl-CoA carboxylase catalyzes the committed and regulated step in fatty acid synthesis. In bacteria, the enzyme is composed of three distinct protein components: biotin carboxylase, biotin carboxyl carrier protein, and carboxyltransferase. Fragment-based screening revealed that amino-oxazole inhibits biotin carboxylase activity and also exhibits antibacterial activity against Gram-negative organisms. In this report, we redesigned previously identified lead inhibitors to expand the spectrum of bacteria sensitive to the amino-oxazole derivatives by including Gram-positive species. Using 9,411 small organic building blocks, we constructed a diverse combinatorial library of 1.2 × 108 amino-oxazole derivatives. A subset
http://www.mdpi.com/1420-3049/19/4/4021/xml
Kinetic and spectroscopic studies on a superoxide dismutase from Propionibacterium shermanii that is active with iron or...Kinetic and spectroscopic studies on a superoxide dismutase from Propionibacterium shermanii that is active with iron or...
Kinetic studies were performed on the superoxide dismutases isolated from the anaerobic bacterium Propionibacterium shermanii as active enzymes with either iron or manganese, which were naturally incorporated into the same molecule depending on the metal supply. Both the Fe- and Mn- forms showed decreasing activity with increasing pH. This suggests the protonation of some groups near the metal, possibly a metal-bound water molecule. Thus the kinetic behaviour of this superoxide dismutase is much more dependent on the protein structure than on the metal incorporated into the active site. The secondary structures of both forms were not influenced by variations in pH, whereas the EPR spectra of the Fe-superoxide dismutase changed as a function of pH. The EPR spectra apparently consist of two overlapping species. Steady-state experiments proved that all iron-containing species show catalytic activity, but the species predominating in the alkaline pH range displays a lower reaction rate. The ...
http://www.biochemj.org/content/310/3/945
Biotin carboxylase | Article about biotin carboxylase by The Free DictionaryBiotin carboxylase | Article about biotin carboxylase by The Free Dictionary
Looking for biotin carboxylase? Find out information about biotin carboxylase. An enzyme which condenses bicarbonate with biotin to form carboxybiotin Explanation of biotin carboxylase
https://encyclopedia2.thefreedictionary.com/biotin+carboxylase
EC 4.1.1.41EC 4.1.1.41
Accepted name: methylmalonyl-CoA decarboxylase. Reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2. Other name(s): propionyl-CoA carboxylase (incorrect); propionyl coenzyme A carboxylase (incorrect); methylmalonyl-coenzyme A decarboxylase; (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect); (S)-methylmalonyl-CoA carboxy-lyase. Systematic name: (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming). Comments: The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-44-4. References:. 1. Galivan, J.H. and Allen, S.H.G. Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus. J. Biol. Chem. 243 (1968) 1253-1261. [PMID: 5646172]. 2. Hilpert, W. and Dimroth, P. Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient. Nature 296 (1982) 584-585. [PMID: 7070502]. 3. ...
http://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC4/1/1/41.html
3,5-Difluoro acetophenone 123577-99-1, China 3,5-Difluoro acetophenone 123577-99-1 Manufacturers, China 3,5-Difluoro...3,5-Difluoro acetophenone 123577-99-1, China 3,5-Difluoro acetophenone 123577-99-1 Manufacturers, China 3,5-Difluoro...
We,China 3,5-Difluoro acetophenone 123577-99-1 Suppliers and China 3,5-Difluoro acetophenone 123577-99-1 Manufacturers, provide 3,5-Difluoro acetophenone 123577-99-1 product and the products related with China 3,5-Difluoro acetophenone 123577-99-1 - jtlchem
http://www.chemnet.com/ChinaSuppliers/16213/3,5-Difluoro-acetophenone--548214.html
KEGG BRITE: KEGG ModulesKEGG BRITE: KEGG Modules
K11263 bccA; acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14 ...
http://www.genome.jp/kegg-bin/get_htext?ko00002+K11262
Propionyl-CoA carboxylase regulator elisa and antibodyPropionyl-CoA carboxylase regulator elisa and antibody
Shop Propionyl-CoA carboxylase regulator ELISA Kit, Recombinant Protein and Propionyl-CoA carboxylase regulator Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=propionyl-coa-carboxylase-regulator
MYLK - Role for Caspase-Mediated Cleavage of Rad51 in Induction of ApoptosisMYLK - Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis
encodes a biotin-dependent oxaloacetate decarboxylase (OAD), which can be constituted by 4 subunits: carboxyltransferase subunit OadA (termed genes was performed in and sole deletion mutants in citrate-supplemented moderate indicated that the experience of the organic is vital for citrate usage. organization from the oxaloacetate decarboxylase involved with citrate usage. (A) The locus can be constituted by genes coding for citrate transporters (could be thought to be the prototype from the Na+-translocating decarboxylase (NaT-DC) category of enzymes. It includes both membrane-bound subunits (OadA (gene, renamed (termed cells during citrate fermentation. Strategies and Components Bacterial strains and development circumstances. Cultures of had been expanded at 37C, without shaking, in Luria-Bertani moderate (LB; Difco, NJ), preliminary pH 7.0, and supplemented with 33 mM trisodium citrate (LBC). Erythromycin was added, when suitable, inside a 5 g ml?1 concentration. Development was supervised by ...
http://ac-devd-cho.com/tag/mylk/
Genetic Mutations & Gene TherapyGenetic Mutations & Gene Therapy
What is the current status of gene therapy research?. The Food and Drug Administration (FDA) has not yet approved any human gene therapy product for sale. Current gene therapy is experimental and has not proven very successful in clinical trials. Little progress has been made since the first gene therapy clinical trial began in 1990. In 1999, gene therapy suffered a major setback with the death of 18-year-old Jesse Gelsinger. Jesse was participating in a gene therapy trial for ornithine transcarboxylase deficiency (OTCD). He died from multiple organ failures 4 days after starting the treatment. His death is believed to have been triggered by a severe immune response to the adenovirus carrier.. Another major blow came in January 2003, when the FDA placed a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. FDA took this action after it learned that a second child treated in a French gene therapy trial had developed a leukemia-like condition. Both this child ...
http://geneticmutationsgenetherapy.yolasite.com/gene-therapy-now.php
Acetophenone Manufacturers | Suppliers | Exporters in IndiaAcetophenone Manufacturers | Suppliers | Exporters in India
Find Leading Acetophenone Manufacturers, Suppliers, Exporters and Traders at one place. Contact Exporters India for more information about Acetophenone manufacturers
http://www.exportersindia.net/manufacturers/acetophenone.html
NASPA Word of the DayNASPA Word of the Day
Definition: SOLON*SOLONS n a wise lawgiver Anagrams: loons nolos snool. Hooks: solonS. Ana-hooks: Bolson Colons Consol loGons loosEn oRlons sAloon snoolS solAno solIon sTolon. Typos: colon salon solan solos. Blana-grams: Bolos Boons Boson Clons Cools Coons Enols Fools Goons Holos Kolos lEnos lInos lIons loAns loBos loCos loGon loGos loIns lonGs looFs looKs looMs loonY looPs loosE looTs loTos Monos Mools Moons noEls noIls noMos nooKs nooNs noosE oBols olEos olIos oRlon osMol Polos Pools Poons sHool sHoon sloMo slooP snooD snooK snooP snooT soKol solDo sonlY soTol sPool sPoon sTool sWoon Tools Toons Wools Zoons. Extensions: solonETS solonETZ solonCHAK solonCHAKS solonETSES solonETZES solonETZIC PREDNIsolonE PREDNIsolonES solonISATION# solonIZATION#. Sub-anagrams: lo loo loon loos no nolo noo nos on ono onos ons os so sol solo son soon ...
https://www.scrabbleplayers.org/cgi-bin/wotd.pl?date=20181111&dict=twl2014
RCSB PDB - 3GLK: The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2)RCSB PDB - 3GLK: The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2)
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/3GLK
EMBL: CP001022.PE450EMBL: CP001022.PE450
CP001022.PE450 Location/Qualifiers FT CDS_pept 483692..484267 FT /codon_start=1 FT /transl_table=11 FT /locus_tag=Exig_0456 FT /product=phosphoribosylglycinamide formyltransferase FT /note=TIGRFAM: phosphoribosylglycinamide FT formyltransferase; PFAM: formyl transferase domain protein; FT KEGG: bcy:Bcer98_0276 phosphoribosylglycinamide FT formyltransferase FT /db_xref=EnsemblGenomes-Gn:Exig_0456 FT /db_xref=EnsemblGenomes-Tr:ACB59938 FT /db_xref=GOA:B1YJ08 FT /db_xref=InterPro:IPR002376 FT /db_xref=InterPro:IPR004607 FT /db_xref=InterPro:IPR036477 FT /db_xref=UniProtKB/TrEMBL:B1YJ08 FT /protein_id=ACB59938.1 FT /translation=MKIACFASGSGSNVEALFEAVETGRLQATIELVVCDQKQAKVIER FT AQARGCDIFVFTAKDYPDKPSFEREIVAELERRGVERIILAGYMRLIGDVLLSHYAGRI FT VNIHPSLLPAFPGKDAIGQAFRGGVKITGVTIHIVDEGMDTGPIIAQEAVRITEDMTRE FT TLQQAIQQVEHRLYPQVIEEWMKEEANV atgaagattg cctgttttgc ctcgggaagt ggcagtaatg tcgaagcttt attcgaagca 60 gttgaaacag gacgtctgca ggctacgatt gaactcgtcg tctgtgatca aaaacaagca 120 aaagtgattg ...
http://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-id?query=CP001022.PE450&db=EMBL&ident=ACNUC7421
Popular Weight Loss Myths: Dont Believe the Hype | HubPagesPopular Weight Loss Myths: Dont Believe the Hype | HubPages
Nowadays, everyone in the gym is a trainer and considers themselves an expert in the field of fitness because they have acquired two muscles. Know the facts and dont believe the hype.
https://hubpages.com/health/Dispelling-the-Weight-Loss-Myths
SOMEONE TELL ME IS THIS WORTH THE HYPE? I SEE … | Q&A for Summer Fridays Cloud Dew Oil-Free Gel Cream 1.70 oz/ 50 mLSOMEONE TELL ME IS THIS WORTH THE HYPE? I SEE … | Q&A for Summer Fridays Cloud Dew Oil-Free Gel Cream 1.70 oz/ 50 mL
People on Influenster are asking: SOMEONE TELL ME IS THIS WORTH THE HYPE? I SEE REVIEWS FROM INFLUENCERS BUT I NEEED NORMAL PEOPLE THANKS
https://www.influenster.com/reviews/summer-fridays-cloud-dew-oil-free-gel-cream-170-oz-50-ml/questions/someone-tell-me-is-this-worth-the-hype-77711926
Noirdrakkar Tries Aventus: Is Aventus Worth The Hype? - Page 2Noirdrakkar Tries Aventus: Is Aventus Worth The Hype? - Page 2
Ive been on this board for more than 8 months. When I first joined, Green Irish Tweed was the favorite horse. But soon after, people started shifting to Creeds Aventus. It soon became, easily, the most acclaimed fragrance on Basenotes. For the past few months, it has been in a lot of top 10 lists, the center of a lot of topics, and in nearly every topic asking for suggestions, someone is going to mention Aventus. Ive never seen this much hype in a fragrance before, ever. Aventus has
http://www.basenotes.net/threads/307565-Noirdrakkar-Tries-Aventus-Is-Aventus-Worth-The-Hype/page2?p=2663591&viewfull=1
Hype & Hope - NewsHype & Hope - News
Hype & Hope is an information and education channel focused on key issues within the life sciences. We provide news, events, editorial, stock indices, video, and image libraries on issues including stem cells, personalized medicine, and clinical trials.
http://hypeandhope.com/stem_cells/stem_cells_news.html
Hype Williams - Rainbow Edition - BoomkatHype Williams - Rainbow Edition - Boomkat
Hype Williams get a pretty headstone with the Rainbow Edition, hustling 20 joints strictly for the whip …& ppl 2 fat for fedoras. Trust its a suitably smoked
https://boomkat.com/products/rainbow-edition
Acca Kappa Beechwood Comb With Handle - StyleInvyteAcca Kappa Beechwood Comb With Handle - StyleInvyte
Acca Kappa combs are designed to protect the hairs natural beauty by reducing damage and breakage to hair. They are unique in both natural beauty and design. *Size:* 7.6
https://www.styleinvyte.com/products/acca-kappa-beechwood-comb-with-handle
SOA? That was just a fad. Cloud Computing? Now that is the real deal. So says Springs Rod JohnsonSOA? That was just a fad. Cloud Computing? Now that is the real deal. So says Springs Rod Johnson
Sadly, its not just VMWare. Even supposedly independent research organizations like Gartner are trumpeting the cloud as loudly as they can these days. Then again, these are the very same people that were at the forefront of the SOA, etc hype too :-).. The technology industry overall seems to hold the unfortunate belief that overblown marketing is an essential tool to sell anything -- even things that do indeed have technical merit. Guess thats where TSS steps in to separate the reality from the hype :-). Fortunately rank-and-file developers in general seem to grasp the concept of the hype cycle. Its the higher-ups in the technology organizations that often dont seem to get it.... ...
http://www.theserverside.com/discussions/thread/62683.html
AcetophenoneAcetophenone
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=C98862&Units=CAL&Mask=2000&Type=LINEAR-RI-NON-POLAR-CUSTOM
Organization and Expression of a Thermus thermophilusArginine Cluster: Presence of Unidentified Open Reading Frames and Absence...Organization and Expression of a Thermus thermophilusArginine Cluster: Presence of Unidentified Open Reading Frames and Absence...
In arginine biosynthesis two alternative pathways have evolved to split off the acetyl group ofN-acetylornithine.Enterobacteriaceae, Vibrionaceae,Myxococcus xanthus, and possibly also the archaeonSulfolobus acidocaldarius use a linear pathway in which the formation of ornithine is mediated by acetyl ornithinase (encoded by argE) (14, 12, 31, 36). Other bacteria, archaea, and eukaryotic microbes recycle the acetyl group by transacetylation of N-acetylornithine and glutamate (26). The transacetylation is catalyzed by ornithine acetyltransferase (encoded by argJ), an enzyme which in some organisms is also able to use acetyl coenzyme A to acetylate glutamate and in this way bypasses the first step of the linear pathway (11, 26). Ornithine carbamoyltransferase (encoded by argF) converts ornithine and carbamoyl phosphate (CP) into citrulline. CP is extremely thermolabile, and in Pyrococcus furiosus(17), Pyrococcus abyssi (25), andThermus thermophilus ZO5 (32), it appears to be protected from thermal ...
https://jb.asm.org/content/182/20/5911
fur protein (Ewingella americana) - STRING interaction networkfur protein (Ewingella americana) - STRING interaction network
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5-adenylate (BirA-bio- 5-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa ...
https://string-db.org/network/910964.GEAM_0756
nikR protein (Klebsiella pneumoniae) - STRING interaction networknikR protein (Klebsiella pneumoniae) - STRING interaction network
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5-adenylate (BirA-bio- 5-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (320 aa ...
https://string-db.org/network/573.JG24_24200
Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro...Contribution of glibenclamide-sensitive, ATP-dependent K+ channel activation to acetophenone analogues-mediated in vitro...
Compared to the currently available therapeutic drugs for peripheral vascular diseases, agents that are selective for relaxing pulmonary circulation are scarce. The present study was undertaken, using isometric tension change measurement and whole-cell patch-clamp electrophysiology methods, to evaluate the vascular relaxation effect and the underlying mechanisms involved of two naturally found alkaloids: paeonol (2-hydroxy-4-methoxy-acetophenone), acetovanillone (4-hydroxy-3-methoxy-acetophenone) and the non-substituted analogue acetophenone on pulmonary artery of Sprague-Dawley rats. Cumulative administration (3 μM-1 mM) of acetophenone analogues resulted in a concentration-dependent relaxation of phenylephrine (1 μM) pre-contracted pulmonary artery. A relative order of inhibitory potency, estimated by comparing the concentration at which a 50% relaxation of phenylephrine-induced contraction observed was: acetovanillone , paeonol , acetophenone. Endothelial denudation and inhibition of nitric ...
https://researchonline.jcu.edu.au/17638/
4-(IMIDAZOL-1-YL)ACETOPHENONE 10041-06-2 H-NMR | C-NMR Spectral Analysis NMR Spectrum4-(IMIDAZOL-1-YL)ACETOPHENONE 10041-06-2 H-NMR | C-NMR Spectral Analysis NMR Spectrum
4-(IMIDAZOL-1-YL)ACETOPHENONE 10041-06-2 NMR spectrum, 4-(IMIDAZOL-1-YL)ACETOPHENONE H-NMR spectral analysis, 4-(IMIDAZOL-1-YL)ACETOPHENONE C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_10041-06-2-moldata-47649.html
TIGR01195TIGR01195
This model finds the subfamily of distantly related, low complexity, hydrophobic small subunits of several related sodium ion-pumping decarboxylases. These include oxaloacetate decarboxylase gamma subunit and methylmalonyl-CoA decarboxylase delta subunit. Most sequences scoring between the noise and trusted cutoffs are eukaryotic sodium channel proteins ...
http://www.jcvi.org/cgi-bin/tigrfams/HmmReportPage.cgi?acc=TIGR01195
Acetophenone Manufacturers, Suppliers, Exporters in Aurangabad, IndiaAcetophenone Manufacturers, Suppliers, Exporters in Aurangabad, India
Get Information of Acetophenone Manufacturers, Suppliers, Dealers, Exporters, Traders, Producers, Wholesalers, Acetophenone Companies in Aurangabad, India
http://www.aurangabadbusiness.com/Products/SearchResult?ProductId=48
SWISS-MODEL Repository | A1VYG1SWISS-MODEL Repository | A1VYG1
SWISS-MODEL Repository entry for A1VYG1 (ACCA_CAMJJ), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha. Campylobacter jejuni subsp jejuni serotype O:23/36 (strain 81-176)
https://swissmodel.expasy.org/repository/uniprot/A1VYG1
The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms...The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms...
Fingerprint Dive into the research topics of The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms Leading to Membrane Damage, Ca2+-Influx and Neurotoxicity. Together they form a unique fingerprint. ...
https://moh-it.pure.elsevier.com/en/publications/the-interaction-between-amyloid-prefibrillar-oligomers-of-salmon-/fingerprints/
32 CFR § 199.2 - Definitions. | CFR | US Law | LII / Legal Information Institute32 CFR § 199.2 - Definitions. | CFR | US Law | LII / Legal Information Institute
Consultation appointment. An appointment for evaluation of medical symptoms resulting in a plan for management which may include elements of further evaluation, treatment and follow-up evaluation. Such an appointment does not include surgical intervention or other invasive diagnostic or therapeutic procedures beyond the level of very simply office procedures, or basic laboratory work but rather provides the beneficiary with an authoritative opinion. Consulting physician or dentist. A physician or dentist, other than the attending physician, who performs a consultation. Conviction. For purposes of this part, conviction or convicted means that (1) a judgment of conviction has been entered, or (2) there has been a finding of guilt by the trier of fact, or (3) a plea of guilty or a plea of nolo contendere has been accepted by a court of competent jurisdiction, regardless of whether an appeal is pending. Coordination of benefits. The coordination, on a primary or secondary payer basis, of the ...
https://www.law.cornell.edu/cfr/text/32/199.2
Free Case Evaluation | LawFirms.comFree Case Evaluation | LawFirms.com
Copyright © 2017 Nolo ® Self-help services may not be permitted in all states. The information provided on this site is not legal advice, does not constitute a lawyer referral service, and no attorney-client or confidential relationship is or will be formed by use of the site. The attorney listings on this site are paid attorney advertising. In some states, the information on this website may be considered a lawyer referral service. Please reference the Terms of Use and the Supplemental Terms for specific information related to your state.Your use of this website constitutes acceptance of the Terms of Use, Supplemental Terms, Privacy Policy and Cookie Policy. 7031 Koll Center Pkwy, Pleasanton, CA 94566. ...
http://www.lawfirms.com/path/min-path2?direct_nid=2860351&practice_area=17783
Radiograpy Requirements Information | Richland Community CollegeRadiograpy Requirements Information | Richland Community College
Background Checks All admitted students will be required to undergo a fingerprint background check before beginning the clinical portion of the Radiography Program. The background check will be coordinated by the Health Professions Office. The cost of the procedure is covered in the Radiography Program summer course fees.. A student with a positive background check including misdemeanors or felony offenses including convictions or charges resulting in a plea of guilty, plea of nolo contendere (no contest), withheld or deferred adjudication, suspended or stay of sentence, pre-trial diversion activity, or military court-martial will not be allowed to enter the clinical portion of the program until the American Registry of Radiologic Technologists Pre-Application Review Process (ARRT , Ethics , Pre-Application Process) has been completed and clearance from the ARRT Ethics committee has been obtained. If students have proof that theyve completed a fingerprint background check within the last 12 ...
http://www.richland.edu/programs/radt/requirements
Ornithine Carbamoyltransferase Antibody (NBP1-88121): Novus BiologicalsOrnithine Carbamoyltransferase Antibody (NBP1-88121): Novus Biologicals
Rabbit Polyclonal Anti-Ornithine Carbamoyltransferase Antibody. Validated: IHC, IHC-P. Tested Reactivity: Human, Mouse, Rat. 100% Guaranteed.
https://www.novusbio.com/products/ornithine-carbamoyltransferase-antibody_nbp1-88121
Omega Fatty Acids - a Hype or Help?Omega Fatty Acids - a Hype or Help?
Take a tour of any supermarket today, and you will be struck by the number of margarine tubs, cooking oils and even yogurts and eggs that have Omega 3 or 6 either in their brand name or added in big letters to the packaging. What is the sudden big deal with Omegas? Are marketers just […]. Omega Fatty Acids - a Hype or Help? is a post from: Time-to-Run Nutrition. Time-to-Run Nutrition. ...
https://www.time-to-run.com/au/nutrition/omega-fatty-acids-%E2%80%93-a-hype-or-help
Omega Fatty Acids - a Hype or Help?Omega Fatty Acids - a Hype or Help?
Take a tour of any supermarket today, and you will be struck by the number of margarine tubs, cooking oils and even yogurts and eggs that have Omega 3 or 6 either in their brand name or added in big letters to the packaging. What is the sudden big deal with Omegas? Are marketers just […]. Omega Fatty Acids - a Hype or Help? is a post from: Time-to-Run Nutrition. Time-to-Run Nutrition. ...
https://www.time-to-tri.com/nutrition/omega-fatty-acids-hype-or-help
Editorials: Screening for Ovarian Cancer-More Hype Than Hope? - American Family PhysicianEditorials: Screening for Ovarian Cancer-More Hype Than Hope? - American Family Physician
In keeping with the principles of the Choosing Wisely campaign, physicians and patients would do well to avoid the pitfalls of overscreening and wait for results that promise more hope than hype.
https://www.aafp.org/afp/2016/0601/p906.html
Hype Barbell set - Gym equipment from monster supplements.com | Monster SupplementsHype Barbell set - Gym equipment from monster supplements.com | Monster Supplements
|p|Greatly reduced price on this Hype barbell set. Normally £520 if sold seperatly. Get the full lot for just £450 plus a barbell rack! Great for kitting out your gym,|/p|
https://monstersupplements.com/hype-barbell-set.html
Shaken by hype, self-driving leaders adopt new strategy: Shutting up - The Washington PostShaken by hype, self-driving leaders adopt new strategy: Shutting up - The Washington Post
After years of self-driving hype, companies are taking a more subdued approach to addressing the tough realities of the most complicated robotic system ever built.
https://www.washingtonpost.com/technology/2018/10/18/shaken-by-hype-self-driving-leaders-adopt-new-strategy-shutting-up/?utm_term=.a96803fec09e
Hype Cycle for Digital Marketing, 2013Hype Cycle for Digital Marketing, 2013
Digital marketers are revolutionizing the entire marketing discipline given advances in technology, access to information and customer access to each other. Gartners Hype Cycle for Digital Marketing enables you to keep up with current and emerging technologies.
https://www.gartner.com/en/documents/2556015
DevOps Demystified: Finding Value in the Hype - Steven Murawski Tickets, Wed, Dec 11, 2013 at 5:30 PM | EventbriteDevOps Demystified: Finding Value in the Hype - Steven Murawski Tickets, Wed, Dec 11, 2013 at 5:30 PM | Eventbrite
Eventbrite - NEWDUG - Northeast Wisconsin Developers User Group presents DevOps Demystified: Finding Value in the Hype - Steven Murawski - Wednesday, December 11, 2013 at Fox Valley Technical College - Room C140ABC, Appleton, WI. Find event and ticket information.
https://www.eventbrite.com/e/devops-demystified-finding-value-in-the-hype-steven-murawski-tickets-8780208841
A question of ethics | Student Accountant magazine archive | Publications | Students | ACCA | ACCA GlobalA question of ethics | Student Accountant magazine archive | Publications | Students | ACCA | ACCA Global
This article gives an overview of ethics and provides a plat form for further study on this vitally important aspect of the work of the professional accountant.
https://www.accaglobal.com/gb/en/student/exam-support-resources/fundamentals-exams-study-resources/f1/technical-articles/question-of-ethics.html
Hyped Nature paper & author knighthood 2 days later raise red flags - The NicheHyped Nature paper & author knighthood 2 days later raise red flags - The Niche
The main meme pushed forward in the hype was that the study proved that 3-person IVF would lead to safe pregnancies. If you focus on the actual data in the paper by the team led by Mary Herbert, it pointed to the opposite conclusion in the form of continuing safety concerns. For many of us in the broader scientific community the intensity of the hype surrounding this paper and the misleading narrative about safety was concerning.. Why was there such a coordinated effort to spin this paper as good news?. On Friday only two days after the publication of this new paper, the BBC reported that Turnbull received a knighthood.. Could this be part of the answer for the hype fest? Whats the scoop here?. In reporting the news on the knighthood the BBC used the same meme noting incorrectly that the research by Turnbull and the others on the team had proven safety: …recent study results showed the technique was safe. The inaccurate text was bolded in the BBC article on the knighthood.. Turnbull has a ...
https://ipscell.com/2016/06/hyped-nature-paper-author-knighthood-2-days-later-raise-red-flags/
Polk 00240 : CDS information --- DoBISCUITPolk 00240 : CDS information --- DoBISCUIT
putative acetyl-CoA carboxylase biotin carboxylase subunit [PokAC2] GTGTTCCGCACCGTCCTCGTCGCCAACCGGGGCGAGATCGCCCTGCGTGTCGCGCGCGCC TGCCGTGAACTGGGGATCAGGGTCGCCGTCGTGTACTCCACCGAGGACACCGACAGCGAG GTCGTGCGGTACGCCGACGAGGCGGTCCGCATCGGCCCGGGGTCGGCGCAGGCGAGCTAC CTCAGCATCCCCGCCGTCATCGAGGCCGCCCGGCGCGTCGGCGCGGACGCGATCCACCCC GGGTACGGATTCCTCTCCGAGAACGCCGACTTCGCCGAGGTGTGCGCGGCCGAGGGCATC ACCTTCATCGGCCCGCCCCCGGAGGTGATGGAGGCGCTGGGCGACAAGTCCACCTGCCGC GGCCTCATGGCCGACGCGGGGCTGCCCCTGCTGCCCGGCACGCTGGACCCCGTGTCGTCG CCGCGCGAGGCCGAGGCGTTCGCCGCCGAGATCGGCTACCCGGTGGTGGTGAAGGCGGTG GCCGGGGGCGGCGGCCGCGGGATCGGAGTGGCGCACTCGGCCGACGAGTTCCCCGCCGTC TACCGGGAGACGCGACGCCACGCCGCCGCCGTGTTCGGGGACGGCAGGGTCTATCTGGAG CGCTATCTGCAGTCCGCACGGCACGTGGAGATCCAGATACTCGCCGACCGCTTCGGCAAT GTGATCCATCTCGGCGAGCGCGACTGCTCGGTGCAGCGCCGCCATCAGAAGCTCATCGAG GAGACCCCGGCTCCCGGGCTGGACCGCGATGTGCTCGCCGCGATGGCGGAACACGCCGTG CAGGGAGCCAAGGCCGCCGGATACGTCGGCGCGGGGACCTTCGAGTTCCTGTACGACGAC AGCGGACGCTTCTACTTCATGGAGGTCAACTGCCGTATCCAGGTCGAGCATCCGGTCACA ...
http://www.bio.nite.go.jp/pks/feature/view/Polk_00240
Wheelchair Kamikaze: Hype or Hope? Much Touted Oral MS Drug Tecfidera (BG 12) Approved byFDA.Wheelchair Kamikaze: Hype or Hope? Much Touted Oral MS Drug Tecfidera (BG 12) Approved byFDA.
Hello all. I found your extremely interesting blog and great stories today on a search for bg 12 vs. Aubagio. I have worked in clinical research as a nurse for 10 years now and it has become increasingly distressing. I have seen time after time wonderful products that are abandoned in Phase III because they didnt help enough people. I have also worked on very effective products (ie Rituximab for RA) that are priced so far out of the market I knew elderly patients mortgaging their homes to meet the co pays. I was completely and utterly shocked by the cost of BG12 and Aubagio. Particulary because of the metabolite nature of Aubagio and common shroom nature of BG12. The article mentioned above at http://www.forbes.com/sites/johnlamattina/2013/04/02/myths-in-the-pricing-of-new-drugs/?partner=yahootix was so interesting and confirms what I have known for years. Big pharma always claims/ claimed they are recouping R & D costs which is bunk. It takes $5-6 billion per compound to make it through the ...
http://www.wheelchairkamikaze.com/2013/03/does-hype-match-hope-much-touted-oral.html?showComment=1370727882032
Wheelchair Kamikaze: Hype or Hope? Much Touted Oral MS Drug Tecfidera (BG 12) Approved byFDA.Wheelchair Kamikaze: Hype or Hope? Much Touted Oral MS Drug Tecfidera (BG 12) Approved byFDA.
Hello all. I found your extremely interesting blog and great stories today on a search for bg 12 vs. Aubagio. I have worked in clinical research as a nurse for 10 years now and it has become increasingly distressing. I have seen time after time wonderful products that are abandoned in Phase III because they didnt help enough people. I have also worked on very effective products (ie Rituximab for RA) that are priced so far out of the market I knew elderly patients mortgaging their homes to meet the co pays. I was completely and utterly shocked by the cost of BG12 and Aubagio. Particulary because of the metabolite nature of Aubagio and common shroom nature of BG12. The article mentioned above at http://www.forbes.com/sites/johnlamattina/2013/04/02/myths-in-the-pricing-of-new-drugs/?partner=yahootix was so interesting and confirms what I have known for years. Big pharma always claims/ claimed they are recouping R & D costs which is bunk. It takes $5-6 billion per compound to make it through the ...
http://www.wheelchairkamikaze.com/2013/03/does-hype-match-hope-much-touted-oral.html?showComment=1366987744496
Skincare Products: Hype vs. RealitySkincare Products: Hype vs. Reality
Walking through the cosmetics section at any department store, there are countless creams, serums, lotions, and potions on display that claim to erase wrinkles
https://www.skinspectrum.com/blog/skincare-products/skincare-products-hype-vs-reality/
Dont believe hydrogen and nuclear hype - they cant get us to net zero carbon by 2050 | Energy | The GuardianDont believe hydrogen and nuclear hype - they cant get us to net zero carbon by 2050 | Energy | The Guardian
Big industry players pushing techno-fixes are ignoring the only realistic solution to the climate crisis: renewables, says environmentalist Jonathon Porritt
https://www.theguardian.com/commentisfree/2021/mar/16/hydrogen-nuclear-net-zero-carbon-renewables
The hydrogen economy: Hope or hype? | CompositesWorldThe hydrogen economy: Hope or hype? | CompositesWorld
Green hydrogen technologies have become the forefront for the global zero-carbon energy landscape. Cost may be what determines its expansion opportunities.
https://www.compositesworld.com/articles/the-hydrogen-economy-hope-or-hype
Cancer and meat - too much hype?Cancer and meat - too much hype?
The World Health Organisations report on the increased cancer risk with eating processed and red meat has been met with mixed reactions.
http://theconversation.com/cancer-and-meat-too-much-hype-49924
Clean Label Foods: Healthy or Just Hype? |...Clean Label Foods: Healthy or Just Hype? |...
Its a hot trend, but clean food doesnt necessarily equal healthy food. Keep these cautions in mind when youre at the grocery store or out to eat.
https://www.parents.com/recipes/scoop-on-food/clean-label-foods-healthy-or-just-hype/
Aluminum hype | MacRumors ForumsAluminum hype | MacRumors Forums
OK, I see difference between plastic and aluminum macbook, but older macbook pro WAS aluminum (and some magnesium which is probably worth more in...
https://forums.macrumors.com/threads/aluminum-hype.581289/
The hype about 5G | Part 2 | Islands SounderThe hype about 5G | Part 2 | Islands Sounder
Note: This is part two of a two-part series about 5G in the San Juan Islands. To read part one, visit https://www.islandssounder.com/news/part-i-the-hype-about-5g/.
https://www.islandssounder.com/news/5g-hype-part-2/
Help or Hype? Treat Your Cold NaturallyHelp or Hype? Treat Your Cold Naturally
Now that cold and flu season is upon us, people are wondering how they can keep themselves healthy, or get rid of their annoying illness, in a more natural way...
https://modernsurvivalonline.com/guest-post-help-or-hype-treat-your-cold-naturally/
The Hoxton Hotel Amsterdam. Believe The Hype! - FabelishThe Hoxton Hotel Amsterdam. Believe The Hype! - Fabelish
Would you like to read Amanda Rijff her view on Fashion, Beauty and Lifestyle? Amanda is a Master Make-up Artitist (MUA) and beauty expert and had over 15.000 woman in her chair for personal make-up advise. Amanda is the author of Flawless.
http://www.fabelish.com/hoxton-hotel-amsterdam-believe-hype/
Krokodil Hype: Is Toxic Flesh-Eating Street Drug In Canada?Krokodil Hype: Is Toxic Flesh-Eating Street Drug In Canada?
If headlines in the past few weeks are to be believed, a Flesh-eating 'zombie' drug that could devour users from the inside out is finding its way onto American stree...
http://www.huffingtonpost.ca/2013/11/25/krokodil-canada_n_4336240.html
Halki Diabetes Remedy Reviews | Examining the Hype 2020 - Health & Fitness VigilanteHalki Diabetes Remedy Reviews | Examining the Hype 2020 - Health & Fitness Vigilante
Do not buy before you read this unbiased Halki Diabetes Remedy Review. Weve examined if the program is worth it and lives up to its promises.
https://www.healthnfitnessvigilante.com/halki-diabetes-remedy-review/
Len Saltz on Hype vs Hope, Drug Costs, and ASCO 2017Len Saltz on Hype vs Hope, Drug Costs, and ASCO 2017
In advance of ASCO 2017, Medscape talks with Dr Len Saltz about the most important challenges facing oncologists and the oncology community.
https://www.medscape.com/viewarticle/880712
Zz Snore Reviews - Is It Legit or Just Hype?Zz Snore Reviews - Is It Legit or Just Hype?
Looking to put an end to your snoring? Zz Snore promises to do just that with its nasal spray formula, claiming to moisturize the airway in your throat.
https://www.highya.com/zz-snore-reviews
Hulu Upfront Hypes Handmaids Tale Success, Shifts Away From Subscriber NumbersHulu Upfront Hypes Handmaids Tale Success, Shifts Away From Subscriber Numbers
CEO Mike Hopkins doubled down on Handmaids Tale and announced exclusive streaming pickups of This Is Us and Atlanta.
https://www.yahoo.com/entertainment/hulu-upfront-hypes-handmaids-tale-success-shifts-away-155605332.html
List of MeSH codes (D08)List of MeSH codes (D08)
... carboxyl and carbamoyl transferases MeSH D08.811.913.555.275.200 - aspartate carbamoyltransferase MeSH D08.811.913.555.275.600 ... glutathione transferase MeSH D08.811.913.225.500.500 - glutathione S-transferase pi MeSH D08.811.913.225.575 - ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ... adp ribose transferases MeSH D08.811.913.400.725.115.180 - cholera toxin MeSH D08.811.913.400.725.115.220 - diphtheria toxin ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
RibonucleotideRibonucleotide
Orotate is covalently linked with phosphoribosyl pyrophosphate (PRPP) by orotate phosphoribysol-transferase yielding orotidine ... A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5-Carboxyaminoimidazole ribonucleotide (N5-CAIR), which is ... ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl ...
https://en.wikipedia.org/wiki/Ribonucleotide
NucleotideNucleotide
... aspartate carbamoyltransferase catalyzes a condensation reaction between aspartate and carbamoyl phosphate to form carbamoyl ... Next, a glycine is incorporated fueled by ATP hydrolysis, and the carboxyl group forms an amine bond to the NH2 previously ... Orotate phosphoribosyltransferase (PRPP transferase) catalyzes the net reaction yielding orotidine monophosphate (OMP): Orotate ... The synthesis of the pyrimidines CTP and UTP occurs in the cytoplasm and starts with the formation of carbamoyl phosphate from ...
https://en.wikipedia.org/wiki/Nucleotide
Aminoacyl tRNA synthetaseAminoacyl tRNA synthetase
The amino acids are attached to the hydroxyl (-OH) group of the adenosine via the carboxyl (-COOH) group. ... EC2 Transferases (list). *EC3 Hydrolases (list). *EC4 Lyases (list). *EC5 Isomerases (list) ...
https://en.wikipedia.org/wiki/Aminoacyl_tRNA_synthetase
Carboxyl and Carbamoyl Transferases | Profiles RNSCarboxyl and Carbamoyl Transferases | Profiles RNS
"Carboxyl and Carbamoyl Transferases" by people in this website by year, and whether "Carboxyl and Carbamoyl Transferases" was a ... "Carboxyl and Carbamoyl Transferases" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, ... Below are the most recent publications written about "Carboxyl and Carbamoyl Transferases" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Carboxyl and Carbamoyl Transferases". ...
https://profiles.uchicago.edu/profiles/display/23980
Transcarboxylase: one of natures early nanomachines.Transcarboxylase: one of nature's early nanomachines.
Carboxyl and Carbamoyl Transferases / metabolism, physiology*. Catalysis. Crystallography, X-Ray. Humans. Magnetic Resonance ... Carboxyl and Carbamoyl Transferases; EC 2.1.3.1/Methylmalonyl-CoA carboxytransferase; EC 4.1.1.41/Methylmalonyl-CoA ...
http://www.biomedsearch.com/nih/Transcarboxylase-one-natures-early-nanomachines/15814455.html
Transferases | definition of transferases by Medical dictionaryTransferases | definition of transferases by Medical dictionary
... transferases explanation free. What is transferases? Meaning of transferases medical term. What does transferases mean? ... Looking for online definition of transferases in the Medical Dictionary? ... carboxyl- and carbamoyltransferases, 2.1.3; and amidinotransferases, 2.1.4); acyl residues (acyltransferases, 2.3); glycosyl ... transferases. Also found in: Dictionary, Thesaurus, Encyclopedia.. Related to transferases: Lyases, Ligases, Hydrolases, ...
https://medical-dictionary.thefreedictionary.com/transferases
List of MeSH codes (D08) - WikipediaList of MeSH codes (D08) - Wikipedia
... carboxyl and carbamoyl transferases MeSH D08.811.913.555.275.200 - aspartate carbamoyltransferase MeSH D08.811.913.555.275.600 ... glutathione transferase MeSH D08.811.913.225.500.500 - glutathione S-transferase pi MeSH D08.811.913.225.575 - ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ... adp ribose transferases MeSH D08.811.913.400.725.115.180 - cholera toxin MeSH D08.811.913.400.725.115.220 - diphtheria toxin ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
Health Sciences Research - Research Output - Mayo ClinicHealth Sciences Research - Research Output - Mayo Clinic
Central pontine myelinolysis as a complication of partial ornithine carbamoyl transferase deficiency. Mattson, L. R., Lindor, N ...
https://mayoclinic.pure.elsevier.com/en/organisations/health-sciences-research/publications/?ordering=title&descending=false&page=3
CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations -...CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations -...
102000007132 Carboxyl and Carbamoyl Transferases Human genes 0 description 1 * 108010072957 Carboxyl and Carbamoyl Transferases ... 108010031311 Intramolecular Transferases Proteins 0 description 1 * 102000005385 Intramolecular Transferases Human genes 0 ... 108010077385 Coenzyme A-Transferases Proteins 0 description 1 * 102000010079 Coenzyme A-Transferases Human genes 0 description ...
https://patents.google.com/patent/CA2426774A1/en
Category:EC 2.1.3Category:EC 2.1.3
... and Carbamoyltransferases Pages in category EC 2.1.3 Additional recommended knowledge Dont let static charges disrupt ... Carboxyl and carbamoyl transferases. O. *Ornithine transcarbamylase. Category: EC 2.1. Topics A-Z ...
https://www.chemeurope.com/en/encyclopedia/Category:EC_2.1.3.html
Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli<...Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli<...
... domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. Initial velocity plots of free Mg2+ vs pyruvate ... while phosphonoacetate inhibited both the phosphorylation of MgADP by carbamoyl phosphate (K-i = 0.026 mM) and pyruvate ... domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. Initial velocity plots of free Mg2+ vs pyruvate ... domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. Initial velocity plots of free Mg2+ vs pyruvate ...
https://research-repository.uwa.edu.au/en/publications/activation-and-inhibition-of-pyruvate-carboxylase-from-rhizobium-
US Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.comUS Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.com
... and related transferases 2.1.3 Carboxyl- and carbamoyltransferases 2.1.4 Amidinotransferases 2.2 Transferring aldehydic or ... aldolyase 4.2.1 Hydro-lyases 1. carbonic anhydrase 5. Isomerase 5.4 Intramolecular transferases 5.4.2 Transferring phosphoryl ... Transferases, Class 4 Lyases and Class 5, Isomerases, can also be of interest in particular situations. The following table has ... Transferases 2.7 Transferring phosphorus-containing groups 2.7.1 Phosphotransferases with CH--OH as acceptor 1. hexokinase 2. ...
http://patents.com/us-4299916.html
DeCSDeCS
Transferase, Carbamoyl. Transferase, Carboxyl. Transferases, Carbamoyl. Transferases, Carboxyl. Tree number(s):. D08.811. ... Carbamoyl Transferase Carbamoyl Transferases Carbamoyltransferase Transferase, Carbamoyl Transferases, Carbamoyl ... Carbamoyl Transferases. Carbamoyltransferase. Carbamoyltransferases. Carboxyl Transferase. Carboxyl Transferases. Carboxyl and ... Carboxyl and carbamoyl transferases Entry term(s):. Carbamoyl Transferase. ...
https://decs.bvsalud.org/en/ths/resource/?id=33459&filter=&q=%E2%8C%A9_another=es
Find Research outputs - the UWA Profiles and Research RepositoryFind Research outputs - the UWA Profiles and Research Repository
Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. - PubMed - NCBIToxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. - PubMed - NCBI
Carboxyl and Carbamoyl Transferases/chemistry*. *Carboxyl and Carbamoyl Transferases/genetics. *Carboxyl and Carbamoyl ...
https://www.ncbi.nlm.nih.gov/pubmed/25079908?dopt=Abstract
DeCS Ingl s+escopoDeCS Ingl s+escopo
Carboxyl and Carbamoyl Transferases .. Carbamoyl Transferases .. Carbamoyltransferases .. Carboxyl Transferases .. ... Transferases, Carbamoyl .. Transferases, Carboxyl .. A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- ... One-Carbon Group Transferases .. One Carbon Group Transferases .. Single Carbon Group Transferases .. Transferases, One-Carbon ... D08.811.913 Transferases .. D08.811.913.555 One-Carbon Group Transferases .. D08.811.913.555.275 Carboxyl and Carbamoyl ...
https://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSxi&lang=i&minsim=0.30&maxrel=10&text=Carboxyl%20and%20Carbamoyl%20Transferases
Search | Global Index MedicusSearch | Global Index Medicus
Anti-Bacterial Agents , Metabolism , Benzoquinones , Metabolism , Carboxyl and Carbamoyl Transferases , Genetics , Chromosome ... Benzoquinones , Metabolism , Carboxyl and Carbamoyl Transferases , Genetics , Lactams, Macrocyclic , Metabolism , Mixed ...
https://search.bvsalud.org/gim/?lang=en&q=mh:Carboxyl+and+Carbamoyl+Transferases
Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain superfamily
The SCOP classification for the Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamily including the ... Transferases. 1. 0. --. INHERITED FROM: Carboxyl- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ... Carboxyl- and carbamoyltransferases. 0.000002517. Highly Informative. Direct. Document: EC annotation of SCOP domains. Enzyme ... Transferases. 1. 0.301. --. INHERITED FROM: Aspartate carbamoyltransferase ,, Carboxy- and carbamoyltransferases. Enzyme ...
http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52021
Carbamoyl phosphate synthetase, large subunit connection domain superfamilyCarbamoyl phosphate synthetase, large subunit connection domain superfamily
The SCOP classification for the Carbamoyl phosphate synthetase, large subunit connection domain superfamily including the ... Transferases. 1. 0. --. INHERITED FROM: Carboxyl- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ... Carboxyl- and carbamoyltransferases. 0.00001407. Highly Informative. Direct. Document: EC annotation of SCOP domains. Enzyme ... Transferases. 1. 0.302. --. INHERITED FROM: Carboxy- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ...
http://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?sunid=48108
ABP73856.1 protein (Shewanella putrefaciens) - STRING interaction networkABP73856.1 protein (Shewanella putrefaciens) - STRING interaction network
... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase. PFAM- phospholipid/glycerol ... PFAM- biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl- ... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (1517 aa) ... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase ...
https://string-db.org/network/319224.Sputcn32_0120
Noca 4502 protein (Nocardioides sp. JS614) - STRING interaction networkNoca 4502 protein (Nocardioides sp. JS614) - STRING interaction network
Carboxyl transferase (497 aa). Predicted Functional Partners:. Noca_4551. Carbamoyl-phosphate synthase subunit L (633 aa) ...
https://string-db.org/network/196162.Noca_4502
Ribonucleotide - WikipediaRibonucleotide - Wikipedia
Orotate is covalently linked with phosphoribosyl pyrophosphate (PRPP) by orotate phosphoribysol-transferase yielding orotidine ... A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5-Carboxyaminoimidazole ribonucleotide (N5-CAIR), which is ... ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl ...
https://en.wikipedia.org/wiki/Ribonucleotide
EMBL: BX251410EMBL: BX251410
"Carboxyl transferase domain Score = 893.4 E-value = FT 4.8e-266" FT CDS_pept 25738..26484 FT /transl_table=11 FT /locus_tag=" ... "PS00867 Carbamoyl-phosphate synthase subdomain FT signature 2." FT misc_feature complement(21874..22210) FT /note="Carbamoyl- ... carboxyl terminus Score = FT 135.1 E-value = 8.7e-38" FT CDS_pept 6438..8897 FT /transl_table=11 FT /gene="gyrA1" FT /locus_tag ... "Formyl transferase Score = 147.5 E-value = 1.7e-41" FT CDS_pept 93477..95105 FT /transl_table=11 FT /gene="purH" FT /locus_tag ...
http://pbil.univ-lyon1.fr/cgi-bin/acnuc-search-ac?query=BX251410&db=EMBL&ident=ACNUC30630
Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full TextGenome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full Text
As a specific example of this process, consider the reaction corresponding to carbamoyl-phosphate synthase (R_CBPS), EC 6.3. ... carboxyl transferase. A0RY61. 8.00E-169. 6.3.4.14. biotin carboxylase. Cthe_0949 ... We found two C. thermocellum genes annotated as "carbamoyl-phosphate synthase, small subunit" (Cthe_1867, Cthe_0950) and two ... a small glutamine-hydrolyzing chain and a large chain that synthesizes carbamoyl phosphate. ...
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-31
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Carbamoyl phosphate combines with aspartate to form carbamoyl aspartate aided by the enzyme aspartate transcarbamoylase. ... It is then convâ ¦ The latter forms an amide with 4-carboxyl group in presence of synthetase, and a succinocarboxamide is ... This is a genetic disorder caused due to the deficiency of the enzyme Hypoxanthine Guanine Phospho Ribosyl Transferase (HGPRT ... in this pathway is the synthesis of carbamoyl phosphate from CO2 and NH4+ by carbamoyl phosphate from CO2 and NH4+ by carbamoyl ...
http://www.abskuwait.com/king-single-zmmgach/dog-friendly-places-in-dubai-2020-72b1a1
Amidinotransferases | REACHAmidinotransferases | REACH
One-Carbon Group Transferases. *Amidinotransferases. *Carboxyl and Carbamoyl Transferases. *Hydroxymethyl and Formyl ... Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. EC 2.1.4. ...
https://reach.sickkids.ca/display/12888
KEGG BRITE: Enzymes - Aeromonas hydrophila pc104AKEGG BRITE: Enzymes - Aeromonas hydrophila pc104A
... acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] K01963 accD; acetyl-CoA carboxylase carboxyl ... 6.3.4.15 biotin---[biotin carboxyl-carrier protein] ligase 6.3.4.16 carbamoyl-phosphate synthase (ammonia) ...
https://www.kegg.jp/kegg-bin/get_htext?ahp01000+V429_18585
Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries
Carboxyl and Carbamoyl Transferases - toxicity , Long-Term Potentiation - drug effects , Neurons - physiology , Escherichia ... Carboxyl and Carbamoyl Transferases - chemistry , Index Medicus ...
https://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:SECRETED%20OLIGOMERS
Methylglyoxal synthase-like superfamilyMethylglyoxal synthase-like superfamily
Carboxyl- and carbamoyltransferases. 1. Highly Informative. Inherited. Enzyme Commission (EC). In cyclic amides. 1. Highly ... Hydroxymethyl-, formyl- and related transferases. 0. 1.356. Informative. DIRECT. Enzyme Commission (EC). Carbamoyl-phosphate ... Carbamoyl-phosphate synthase (ammonia). 0.0000000000225. 2.233. Highly Informative. DIRECT. Enzyme Commission (EC). Carboxyl- ... Hydroxymethyl-, formyl- and related transferases. 0. Informative. Direct. Enzyme Commission (EC). Carbamoyl-phosphate synthase ...
http://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52335
METHODS AND COMPOSITIONS FOR ISOLATING, IDENTIFYING AND CHARACTERIZING MONOCOT PLASTIDIC ACCASE HERBICIDE TOLERANT...METHODS AND COMPOSITIONS FOR ISOLATING, IDENTIFYING AND CHARACTERIZING MONOCOT PLASTIDIC ACCASE HERBICIDE TOLERANT...
0157] Region 8: pfam01039 (Carboxyl_trans) Carboxyl transferase domain (of biotin-dependent carboxylases). [0158] The carboxyl ... 0151] Region 3: pfam02786 (CPSase_L_D2) Carbamoyl-phosphate synthase L chain, ATP binding domain; [0152] Region 4: pfam02785 ( ... 0128] As used herein, and "herbicide sensitivity region" (HSR) is an amino acid sequence present in the carboxyl transferase ... 0159] Region 8 comprises the carboxyl transferase domain of the ACCase enzyme of the invention. Herbicide sensitivity has been ...
http://www.patentsencyclopedia.com/app/20140377835
Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli by Tonya N. Zeczycki, Ann L. Menefee et al."Activation and Inhibition of Pyruvate Carboxylase from Rhizobium etli" by Tonya N. Zeczycki, Ann L. Menefee et al.
... while phosphonoacetate inhibited both the phosphorylation of MgADP by carbamoyl phosphate (Ki = 0.026 mM) and pyruvate ... domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. Initial velocity plots of free Mg2+ vs pyruvate ... domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. Initial velocity plots of free Mg2+ vs pyruvate ... while phosphonoacetate inhibited both the phosphorylation of MgADP by carbamoyl phosphate (Ki = 0.026 mM) and pyruvate ...
https://epublications.marquette.edu/bio_fac/124/
The use of proteomic techniques to study the physiology and virulence of staphylococcus aureus The use of proteomic techniques to study the physiology and virulence of staphylococcus aureus
... carboxyl transferase, beta subunit (accD) SACOL1748 3 sdrC protein (sdrC) SACOL0608 2 Staphylococcus aureus sex pheromone (camS ... PUR9 18 6 Carbamoyl phosphate synthase large chain Q5HGM9,CARB 12 12 Probable thiol peroxidase Q5HF61,TPX 14 7 Chaperone ... DEF 0 2 Acetyl coenzyme A carboxylase carboxyl transferase subunit alpha Q5HF74,ACCA 3 0 UDP N acetylmuramoylalanine -D ... PTPA 5 2 Acetyl coenzyme A carboxylase carboxyl transferase subunit beta Q5HF73,ACCD 4 4 GTP sensing transcriptional ...
http://digital.lib.usf.edu/SFS0028061/00001
Search | Global Index MedicusSearch | Global Index Medicus
Benzoquinones , Metabolism , Carboxyl and Carbamoyl Transferases , Genetics , Lactams, Macrocyclic , Metabolism , Mixed ...
https://search.bvsalud.org/gim/?lang=en&q=au:Weiqing+HE
Biotin carboxylasePhosphateSynthetaseEnzymesOrnithineEnzymeAspartateCatalysisHydroxylSubclassComtCysteineMeSHGroupDrugsAmino AcidsDecarboxylationAlphaHumansGlutamineActivityYearStructure
Biotin carboxylase3
  • The current steady-state kinetic investigation indicates that both acetyl-CoA and Mg2+ assist in coupling the MgATP-dependent carboxylation of biotin in the biotin carboxylase (BC) domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. (edu.au)
  • The current steady-state kinetic investigation indicates that both acetyl-CoA and Mg 2+ assist in coupling the MgATP-dependent carboxylation of biotin in the biotin carboxylase (BC) domain with pyruvate carboxylation in the carboxyl transferase (CT) domain. (marquette.edu)
  • In Escherichia coli, ACC is comprised of three functional modules: the biotin carboxylase (BC), the biotin carboxyl carrier protein (BCCP) and the carboxyl transferase (CT). (embl-heidelberg.de)
Phosphate6
  • Acetyl phosphate was determined to be a suitable phosphoryl donor for the catalytic phosphorylation of MgADP, while phosphonoacetate inhibited both the phosphorylation of MgADP by carbamoyl phosphate (K-i = 0.026 mM) and pyruvate carboxylation (K-i = 2.5 mM). (edu.au)
  • An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (bireme.br)
  • Pyrimidines are synthesized first from aspartate and carbamoyl-phosphate in the cytoplasm to the common precursor ring structure orotic acid, onto which a phosphorylated ribosyl unit is covalently linked. (meddic.jp)
  • The synthesis of the pyrimidines CTP and UTP occurs in the cytoplasm and starts with the formation of carbamoyl phosphate from glutamine and CO 2 . (meddic.jp)
  • Next, aspartate undergoes a condensation reaction with carbamoyl-phosphate to form orotic acid. (meddic.jp)
  • carbamoyl-phosphate synthetase 2, asp. (broadinstitute.org)
Synthetase1
  • It is then convâ ¦ The latter forms an amide with 4-carboxyl group in presence of synthetase, and a succinocarboxamide is formed. (abskuwait.com)
Enzymes2
  • A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. (uchicago.edu)
  • Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. (sickkids.ca)
Ornithine1
  • Arginine deiminase, ornithine carbamoyl transferase, and enolase have been identified from secreted proteins of Giardia intestinalis as immunodominant antigens [ 9 ]. (parasitol.kr)
Enzyme2
  • In a subsequent cyclization reaction, the enzyme Aspartate carbamoyltransferase forms N-carbamoyl-aspartate which is converted into dihydroorotic acid by dihydroorotase. (meddic.jp)
  • The enzyme takes the end methyl residue from the methionine side chain and adds it to the side chain carboxyl group of L-isoaspartate or D-aspartate to create a methyl ester. (xfam.org)
Aspartate1
  • Fluoride induced increase in the activities of Alanine and Aspartate transferases were reported (Miszta and Dabrowski, 1986), in Wistan rats. (thefreedictionary.com)
Catalysis1
  • During catalysis, carboxybiotin is translocated to the carboxyltransferase domain where the carboxyl group is transferred to the acceptor substrate, pyruvate. (embl-heidelberg.de)
Hydroxyl3
  • Q: Where do the carboxyl and hydroxyl groups point in bile salts? (caribbeanmedstudent.com)
  • Q: How many carboxyl and how many hydroxyl groups are in a bile salt? (caribbeanmedstudent.com)
  • The amino acids are attached to the hydroxyl (-OH) group of the adenosine via the carboxyl (-COOH) group. (wikipedia.org)
Subclass1
  • A subclass of transferases that transfer chemical groups containing a single carbon. (bireme.br)
Comt1
  • 11. The method according to claim 10, wherein said at least one other pharmaceutically active ingredient is chosen from the group consisting of: levodopa, carbidopa-levodopa, dopamine agonists, monoamine oxidase B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, NMDA receptor antagonists, acetylcholinesterase inhibitors, and mixture thereof. (sumobrain.com)
Cysteine1
  • Subsequently, the sequence AAX is proteolytically cleaved, and the newly formed carboxyl-terminal farnesyl cysteine is finally methylated ( Zhang and Casey, 1996 ). (aspetjournals.org)
MeSH1
  • Carboxyl and Carbamoyl Transferases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Group2
  • Many studies on the carboxyltransferase domain of PC have demonstrated an enhanced oxaloacetate decarboxylation activity in the presence of oxamate and it has been shown that oxamate accepts a carboxyl group from carboxybiotin during oxaloacetate decarboxylation. (embl-heidelberg.de)
  • The surface of the micro/nanomaterial comprises a carboxyl group or poten. (sumobrain.com)
Drugs1
  • Another approach involves the use of vegetable drugs such as Polygalae root extract, which has been shown to enhance choline-acetylcholine transferase (CAT) activity and nerve growth factor (NGF) secretion in brain. (allindianpatents.com)
Amino Acids1
  • PIMT acts to transfer methyl groups from S-adenosyl-L-methionine to the alpha side chain carboxyl groups of damaged L-isoaspartyl and D-aspartyl amino acids. (xfam.org)
Decarboxylation1
  • PRPP transferase catalyzes both the ribosylation and decarboxylation reactions, forming UMP from orotic acid in the presence of PRPP. (meddic.jp)
Alpha1
  • Microsomal and alpha-class glutathione transferases were also induced transcriptionally. (thefreedictionary.com)
Humans1
  • Zeta, a novel class of glutathione transferases in a range of species from plants to humans. (thefreedictionary.com)
Glutamine1
  • This compound interacts with water and L-glutamine through a amidophosphoribosyl transferase resulting in a pyrophosphate, L-glutamic acid and a 5-phosphoribosylamine. (kasinokamu.com)
Activity2
  • Glutathione s transferase and hydrolytic activity in a tetrachlorvinphos-resistant strain of housefly and their influence on resistance. (thefreedictionary.com)
  • Glutathione transferases structure and catalytic activity. (thefreedictionary.com)
Year1
  • This graph shows the total number of publications written about "Carboxyl and Carbamoyl Transferases" by people in this website by year, and whether "Carboxyl and Carbamoyl Transferases" was a major or minor topic of these publications. (uchicago.edu)
Structure1
  • Liu, Crystallographic and Mechanistic Studies of Class Mu Glutathione S- Transferases , in Proceedings of the International Meeting on Structure and Function of Glutathione Transferases , K. (thefreedictionary.com)