Ornithine Carbamoyltransferase: A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.Ornithine Carbamoyltransferase Deficiency Disease: An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)Carboxyl and Carbamoyl Transferases: A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3.Carbamyl Phosphate: The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).Carbamoyl-Phosphate Synthase (Ammonia): An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing): An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.Transferases: Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor:acceptor group transferase". (Enzyme Nomenclature, 1992) EC 2.Aspartate Carbamoyltransferase: An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.Carbamates: Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.Alkyl and Aryl Transferases: A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.Phosphotransferases (Carboxyl Group Acceptor): A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Transferases (Other Substituted Phosphate Groups): A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.Carbon-Nitrogen Ligases: Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Kinetics: The rate dynamics in chemical or physical systems.Ammonia: A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.CitrullineOrotic AcidDNA Nucleotidylexotransferase: A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Azauridine: A triazine nucleoside used as an antineoplastic antimetabolite. It interferes with pyrimidine biosynthesis thereby preventing formation of cellular nucleic acids. As the triacetate, it is also effective as an antipsoriatic.Coenzyme A-Transferases: Enzymes which transfer coenzyme A moieties from acyl- or acetyl-CoA to various carboxylic acceptors forming a thiol ester. Enzymes in this group are instrumental in ketone body metabolism and utilization of acetoacetate in mitochondria. EC 2.8.3.Ligases: A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (Dorland, 28th ed) EC 6.Dogfish: Sharks of the family Squalidae, also called dogfish sharks. They comprise at least eight genera and 44 species. Their LIVER is valued for its oil and its flesh is often made into fertilizer.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.Dihydroorotase: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.Urea: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Light-dependent changes in redox status of the plastidic acetyl-CoA carboxylase and its regulatory component. (1/77)

Plastidic acetyl-CoA carboxylase (ACCase; EC 6.4.1.2), which catalyses the synthesis of malonyl-CoA and is the regulatory enzyme of fatty acid synthesis, is activated by light, presumably under redox regulation. To obtain evidence of redox regulation in vivo, the activity of ACCase was examined in pea chloroplasts isolated from plants kept in darkness (dark-ACCase) or after exposure to light for 1 h (light-ACCase) in the presence or absence of a thiol-reducing agent, dithiothreitol (DTT). The protein level was similar for light-ACCase and dark-ACCase, but the activity of light-ACCase in the absence of DTT was approx. 3-fold that of dark-ACCase. The light-ACCase and dark-ACCase were activated approx. 2-fold and 6-fold by DTT respectively, indicating that light-ACCase was in a much more reduced, active form than the dark-ACCase. This is the first demonstration of the light-dependent reduction of ACCase in vivo. Measurement of the activities of ACCase, carboxyltransferase and biotin carboxylase in the presence and absence of DTT, and the thiol-oxidizing agent, 5, 5'-dithiobis-(2-nitrobenzoic) acid, revealed that the carboxyltransferase reaction, but not the biotin carboxylase reaction, was redox-regulated. The cysteine residue(s) responsible for redox regulation probably reside on the carboxyltransferase component. Measurement of the pH dependence of biotin carboxylase and carboxyltransferase activities in the ACCase suggested that both components affect the activity of ACCase in vivo at a physiological pH range. These results suggest that the activation of ACCase by light is caused partly by the pH-dependent activation of two components and by the reductive activation of carboxyltransferase.  (+info)

The biotin domain peptide from the biotin carboxyl carrier protein of Escherichia coli acetyl-CoA carboxylase causes a marked increase in the catalytic efficiency of biotin carboxylase and carboxyltransferase relative to free biotin. (2/77)

Acetyl-CoA carboxylase catalyzes the first committed step in the biosynthesis of long-chain fatty acids. The Escherichia coli form of the enzyme consists of a biotin carboxylase activity, a biotin carboxyl carrier protein, and a carboxyltransferase activity. The C-terminal 87 amino acids of the biotin carboxyl carrier protein (BCCP87) form a domain that can be independently expressed, biotinylated, and purified (Chapman-Smith, A., Turner, D. L., Cronan, J. E., Morris, T. W., and Wallace, J. C. (1994) Biochem. J. 302, 881-887). The ability of the biotinylated form of this 87-residue protein (holoBCCP87) to act as a substrate for biotin carboxylase and carboxyltransferase was assessed and compared with the results with free biotin. In the case of biotin carboxylase holoBCCP87 was an excellent substrate with a K(m) of 0.16 +/- 0.05 mM and V(max) of 1000.8 +/- 182.0 min(-1). The V/K or catalytic efficiency of biotin carboxylase with holoBCCP87 as substrate was 8000-fold greater than with biotin as substrate. Stimulation of the ATP synthesis reaction of biotin carboxylase where carbamyl phosphate reacted with ADP by holoBCCP87 was 5-fold greater than with an equivalent amount of biotin. The interaction of holoBCCP87 with carboxyltransferase was characterized in the reverse direction where malonyl-CoA reacted with holoBCCP87 to form acetyl-CoA and carboxyholoBCCP87. The K(m) for holoBCCP87 was 0.45 +/- 0.07 mM while the V(max) was 2031.8 +/- 231.0 min(-1). The V/K or catalytic efficiency of carboxyltransferase with holoBCCP87 as substrate is 2000-fold greater than with biotin as substrate.  (+info)

Herbicide sensitivity determinant of wheat plastid acetyl-CoA carboxylase is located in a 400-amino acid fragment of the carboxyltransferase domain. (3/77)

A series of chimeral genes, consisting of the yeast GAL10 promoter, yeast ACC1 leader, wheat acetyl-CoA carboxylase (ACCase; EC 6.4.1.2) cDNA, and yeast ACC1 3'-tail, was used to complement a yeast ACC1 mutation. These genes encode a full-length plastid enzyme, with and without the putative chloroplast transit peptide, as well as five chimeric cytosolic/plastid proteins. Four of the genes, all containing at least half of the wheat cytosolic ACCase coding region at the 5'-end, complement the yeast mutation. Aryloxyphenoxypropionate and cyclohexanedione herbicides, at concentrations below 10 microM, inhibit the growth of haploid yeast strains that express two of the chimeric ACCases. This inhibition resembles the inhibition of wheat plastid ACCase observed in vitro and in vivo. The differential response to herbicides localizes the sensitivity determinant to the third quarter of the multidomain plastid ACCase. Sequence comparisons of different multidomain and multisubunit ACCases suggest that this region includes part of the carboxyltransferase domain, and therefore that the carboxyltransferase activity of ACCase (second half-reaction) is the target of the inhibitors. The highly sensitive yeast gene-replacement strains described here provide a convenient system to study herbicide interaction with the enzyme and a powerful screening system for new inhibitors.  (+info)

Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). (4/77)

Two genes, accA1 and accA2, with nearly identical nucleotide sequences were cloned from Streptomyces coelicolor A3(2). The deduced amino acid sequences of the product of these two genes showed high similarity to BcpA2 of Saccharopolyspora erythraea and other biotin-containing proteins from different organisms assumed to be the alpha subunit of a propionyl-CoA carboxylase. A gene, pccB, encoding the carboxyl transferase subunit of this enzyme complex was also characterized. Strains disrupted in accA1 did not show any change in acetyl- or propionyl-CoA carboxylase activity, whilst cell-free extracts of a pccB mutant strain contained a reduced level of propionyl-CoA carboxylase. No mutants in accA2 could be isolated, suggesting that the gene may be essential. Heterologous expression of accA1, accA2 and pccB in Escherichia col and in vitro reconstitution of enzyme activity confirmed that PccB is the beta subunit of a propionyl-CoA carboxylase and that either AccA1 or AccA2 could act as the alpha component of this enzyme complex. The fact that accA2 mutants appear to be inviable suggests that this gene encodes a biotinylated protein that might be shared with other carboxyl transferases essential for the growth of S. coelicolor.  (+info)

Metabolic biotinylation of recombinant proteins in mammalian cells and in mice. (5/77)

The avidin-biotin system is a fundamental technology in biomedicine for immunolocalization, imaging, nucleic acid blotting, and protein labeling. While this technology is robust, it is limited by the fact that mammalian proteins must be expressed and purified prior to chemical biotinylation using cross-linking agents which modify proteins at random locations to heterogeneous levels and can inactivate protein function. To circumvent this limitation, we demonstrate the ability to metabolically biotinylate tagged proteins in mammalian cells and in mice using the endogenous biotinylation enzymes of the host. Endogenously biotinylated proteins were readily purified from mammalian cells using monomeric avidin and eluted under nondenaturing conditions using only biotin as the releasing agent. This technology should allow recombinant proteins and fragile protein complexes to be produced and purified from mammalian cells as well as from transgenic plants and animals. In addition, this technology may be particularly useful for cell-targeting applications in which proteins or viral gene therapy vectors can be biotinylated at genetically defined sites for combination with other targeting moieties complexed with avidin.  (+info)

Molecular cloning and characterization of two genes for the biotin carboxylase and carboxyltransferase subunits of acetyl coenzyme A carboxylase in Myxococcus xanthus. (6/77)

We have cloned a DNA fragment from a genomic library of Myxococcus xanthus using an oligonucleotide probe representing conserved regions of biotin carboxylase subunits of acetyl coenzyme A (acetyl-CoA) carboxylases. The fragment contained two open reading frames (ORF1 and ORF2), designated the accB and accA genes, capable of encoding a 538-amino-acid protein of 58.1 kDa and a 573-amino-acid protein of 61.5 kDa, respectively. The protein (AccA) encoded by the accA gene was strikingly similar to biotin carboxylase subunits of acetyl-CoA and propionyl-CoA carboxylases and of pyruvate carboxylase. The putative motifs for ATP binding, CO(2) fixation, and biotin binding were found in AccA. The accB gene was located upstream of the accA gene, and they formed a two-gene operon. The protein (AccB) encoded by the accB gene showed high degrees of sequence similarity with carboxyltransferase subunits of acetyl-CoA and propionyl-CoA carboxylases and of methylmalonyl-CoA decarboxylase. Carboxybiotin-binding and acyl-CoA-binding domains, which are conserved in several carboxyltransferase subunits of acyl-CoA carboxylases, were found in AccB. An accA disruption mutant showed a reduced growth rate and reduced acetyl-CoA carboxylase activity compared with the wild-type strain. Western blot analysis indicated that the product of the accA gene was a biotinylated protein that was expressed during the exponential growth phase. Based on these results, we propose that this M. xanthus acetyl-CoA carboxylase consists of two subunits, which are encoded by the accB and accA genes, and occupies a position between prokaryotic and eukaryotic acetyl-CoA carboxylases in terms of evolution.  (+info)

An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors. (7/77)

cDNA fragments encoding the carboxyltransferase domain of the multidomain plastid acetyl-CoA carboxylase (ACCase) from herbicide-resistant maize and from herbicide-sensitive and herbicide-resistant Lolium rigidum were cloned and sequenced. A Leu residue was found in ACCases from herbicide-resistant plants at a position occupied by Ile in all ACCases from sensitive grasses studied so far. Leu is present at the equivalent position in herbicide-resistant ACCases from other eukaryotes. Chimeric ACCases containing a 1000-aa fragment of two ACCase isozymes found in a herbicide-resistant maize were expressed in a yeast ACC1 null mutant to test herbicide sensitivity of the enzyme in vivo and in vitro. One of the enzymes was resistant/tolerant, and one was sensitive to haloxyfop and sethoxydim, rendering the gene-replacement yeast strains resistant and sensitive to these compounds, respectively. The sensitive enzyme has an Ile residue, and the resistant one has a Leu residue at the putative herbicide-binding site. Additionally, a single Ile to Leu replacement at an equivalent position changes the wheat plastid ACCase from sensitive to resistant. The effect of the opposite substitution, Leu to Ile, makes Toxoplasma gondii apicoplast ACCase resistant to haloxyfop and clodinafop. In this case, inhibition of the carboxyltransferase activity of ACCase (second half-reaction) of a large fragment of the Toxoplasma enzyme expressed in Escherichia coli was tested. The critical amino acid residue is located close to a highly conserved motif of the carboxyltransferase domain, which is probably a part of the enzyme active site, providing the basis for the activity of fop and dim herbicides.  (+info)

Motility of single one-headed kinesin molecules along microtubules. (8/77)

The motility of single one-headed kinesin molecules (K351 and K340), which were truncated fragments of Drosophila two-headed kinesin, has been tested using total internal reflection fluorescence microscopy. One-headed kinesin fragments moved continuously along the microtubules. The maximum distance traveled until the fragments dissociated from the microtubules for both K351 and K340 was approximately 600 nm. This value is considerably larger than the space resolution of the measurement system (SD approximately 30 nm). Although the movements of the fragments fluctuated in forward and backward directions, statistical analysis showed that the average movements for both K340 and K351 were toward the plus end of the microtubules, i.e., forward direction. When BDTC (a 1.3-S subunit of Propionibacterium shermanii transcarboxylase, which binds weakly to a microtubule), was fused to the tail (C-terminus) of K351, its movement was enhanced, smooth, and unidirectional, similar to that of the two-headed kinesin fragment, K411. However, the travel distance and velocity of K351BDTC molecules were approximately 3-fold smaller than that of K411. These observations suggest that a single kinesin head has basal motility, but coordination between the two heads is necessary for stabilizing the basal motility for the normal level of kinesin processivity.  (+info)

*List of MeSH codes (D08)

... carboxyl and carbamoyl transferases MeSH D08.811.913.555.275.200 --- aspartate carbamoyltransferase MeSH D08.811.913.555. ... glutathione transferase MeSH D08.811.913.225.500.500 --- glutathione S-transferase pi MeSH D08.811.913.225.575 --- ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 --- carbon-nitrogen ligases with glutamine as amide-n-donor ... carboxyl group acceptor) MeSH D08.811.913.696.630.025 --- acetate kinase MeSH D08.811.913.696.630.050 --- aspartate kinase MeSH ...

*Ribonucleotide

Orotate is covalently linked with phosphoribosyl pyrophosphate (PRPP) by orotate phosphoribysol-transferase yielding orotidine ... A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5-Carboxyaminoimidazole ribonucleotide (N5-CAIR), which is ... ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl ...

*Nucleotide

... aspartate carbamoyltransferase catalyzes a condensation reaction between aspartate and carbamoyl phosphate to form carbamoyl ... Next, a glycine is incorporated fueled by ATP hydrolysis and the carboxyl group forms an amine bond to the NH2 previously ... Orotate phosphoribosyltransferase (PRPP transferase) catalyzes the net reaction yielding orotidine monophosphate (OMP): Orotate ... The synthesis of the pyrimidines CTP and UTP occurs in the cytoplasm and starts with the formation of carbamoyl phosphate from ...

*DNA

N6-carbamoyl-methyladenine was described in 1975. 7-methylguanine was described in 1976. N4-methylcytosine in DNA was described ... These modifications are the addition of methyl (CH3)-, hydroxymethyl (CH2OH)-, formyl (CHO)- and carboxyl (COOH)- groups. These ... Greider CW, Blackburn EH (December 1985). "Identification of a specific telomere terminal transferase activity in Tetrahymena ... Modified Adenosine N6-carbamoyl-methyladenine N6-methyadenine Modified Guanine 7-Methylguanine Modified Cytosine N4- ...
Acetyl-CoA carboxylase is the first and committed step of de novo fatty acid synthesis in all organisms. In Escherichia coli, the enzyme is expressed as separate proteins for the three functional components: a biotin carboxylase, a biotin carboxyl carrier protein, and a carboxyltransferase. The carboxyltransferase enzyme has an α2β2 heterotetrameric quaternary arrangement. The crystal structure of the β subunit revealed a zinc-binding domain, a feature common among nucleic acid-binding proteins. Carboxyltransferase preferentially binds mRNA coding for its two subunits over other nucleic acids, suggesting a means by which the enzyme can regulate its own expression. In the first study, the role played by the zinc-binding motif in carboxyltransferase is revealed through site-directed mutagenesis of the four coordinating cysteinyl residues. Results indicate that the zinc-binding domain is involved in both enzymatic activity of the enzyme as well as mediating binding of the enzyme to its own subunit mRNA.
Acetyl-CoA carboxylase is an essential enzyme, as it catalyzes the first committed and regulated step in fatty-acid biosynthesis in all organisms excepting few Archaea and Eubacteria. Acetyl-CoA carboxylase from gram-negative and gram-positive bacteria is a multifunctional enzyme composed of three separate proteins. The carboxyltransferase subunit catalyzes the transfer of a carboxyl group from carboxybiotin to acetyl-CoA, forming malonyl-CoA. The crystal structure of the Escherichia coli (E. coli) carboxyltransferase component of acetyl-CoA carboxylase revealed a unique Zn-domain, presumed to mediate nucleic acid binding, that is absent in the eukaryotic enzyme. Notably, the Zn-domain, adjacent to the active site of carboxyltransferase, makes for a unique target in the development of novel antibiotics capable of highly specific binding. Utilizing an Electrophoretic Mobility Shift Assay as part of this study, we investigated the nonspecific nucleic-acid binding and substrate (malonyl-CoA and biocytin)
|p|Find out whether you can withhold rent or use the “repair and deduct” remedy in your state if your landlord fails to fix major problems in your rental unit.|/p| |div class=responsive-state-list-large| |p||a class=blue href=http://www.nolo.com/legal-encyclopedia/alabama-tenant-rights-withhold-rent.html|Alabama|/a||br /| |a class=blue href=http://www.nolo.com/legal-encyclopedia/alaska-tenant-rights-withhold-rent-repair-deduct.html|Alaska|/a||br /| |a class=blue href=http://www.nolo.com/legal-encyclopedia/arizona-tenant-rights-withhold-rent-repair-deduct.html|Arizona|/a||br /| |a class=blue href=http://www.nolo.com/legal-encyclopedia/arkansas-tenant-rights-rent-withholding.html|Arkansas|/a||br /| |a class=blue href=http://www.nolo.com/legal-encyclopedia/california-tenant-rights-withhold-rent-repair-deduct.html|California|/a||br /| |a class=blue href=http://www.nolo.com/legal-encyclopedia/colorado-tenant-rights-withhold-rent.html|Colorado|/a||br /| |a class=blue
Zakrsl druh ban novn ku dorust pouh ch 1, 2 m. Listy jsou sv e zelen - jemn voskov . Kv ty bananovn ku jsou r ov a oran ov . Ban novn k ma velmi dekorativn plody o velikosti cca 7cm a r ov barvy. Plody jsou jedl a velmi sladk ! Tento druh ban novn ku je velmi tolerantn v i chladu, m ete jej m t v chladn j chodb , kde teplota nekles pod 0. Pokud jej hodn zazimujeme vyd I zimni obdob venku. Vhodn zejm na pro p stov n v byt ...
Novan Inc (NASDAQ:NOVN)s share price hit a new 52-week low during trading on Friday . The company traded as low as $3.40 and last traded at $4.24, with a volume of 19900 shares. The stock had previously closed at $4.30. NOVN has been the subject of a number of recent research reports. ValuEngine raised shares […]
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A legal rule that a person who causes injury is at fault for all the consequences whether foreseen or not. It is derived from a situation in which a light blow to the head killed an individual, even though it could not have been predicted that such a blow would cause death.
A quit claim deed or deed form allows for the transfer of property from one individual to another without any guarantee as to the transferring persons interest, according to Nolo. It transfers...
La metilmalonil-CoA carbossitransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: (S)-metilmalonil-CoA + piruvato ⇄ propanoil-CoA + ossaloacetato Lenzima è una proteina biotinilata, contenente cobalto e zinco. Hoffmann, A., Hilpert, W. and Dimroth, P., The carboxyltransferase activity of the sodium-ion-translocating methylmalonyl-CoA decarboxylase of Veillonella alcalescens, in Eur. J. Biochem., vol. 179, 1989, pp. 645-650, Entrez PubMed 2920730. Swick, R.W. and Wood, H.G., The role of transcarboxylation in propionic acid fermentation, in Proc. Natl. Acad. Sci. USA, vol. 46, 1960, pp. 28-41 ...
Although human transthyretin (TTR) is associated with systemic amyloidoses, an anti-amyloidogenic effect that prevents Aβ fibril formation in vitro and in animalmodels has been observed. Herewe studied the ability of three different types of TTR, namely human tetramers (hTTR),mouse tetramers (muTTR) and an engineered monomer of the human protein (M-TTR), to suppress the toxicity of oligomers formed by two different amyloidogenic peptides/proteins (HypF-N and Aβ42). muTTR is the most stable homotetramer, hTTR can dissociate into partially unfolded monomers, whereas M-TTR maintains a monomeric state. Preformed toxic HypF-N and Aβ42 oligomers were incubated in the presence of each TTR then added to cell culture media. hTTR, and to a greater extent MTTR, were found to protect human neuroblastoma cells and rat primary neurons against oligomer-induced toxicity, whereas muTTR had no protective effect. The thioflavin T assay and site-directed labeling experiments using pyrene ruled out disaggregation ...
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
nolo enim vos ignorare fratres quoniam patres nostri omnes sub nube fuerunt et omnes mare transierunt et omnes in Mose baptizati sunt in nube et in
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
Novartis (VTX:NOVN) has been given a CHF 90 price objective by equities research analysts at Deutsche Bank in a research note issued on Monday. The firm presently has a
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Designed to inject a whole lot more power into any existing smartphone-based VR product, the system adds room-scale tracking with six degrees of freedom, along with a pair of controllers.
Well, somebody covered her ass. As she bleated out, nolo contendere.... The picture on the ground in SD, and several other states, is very bleak for women... but as I cast my mind back over a year long of online - and so very DLC it has been - demagoguery of NARAL (imo, there is a buzzing bee up Koss ass), and, while I believe in very harsh criticism of pols, lobbyists, hacks and others, I have been around the block... and there is a difference. Demagoguery is meant to demonise.. The past 6 weeks the demagoguery starts to extend, across the board, from NARAL to PPFA. Often involving a small circle of "incestuous amplification" blogs who tie in tightly via, again!, incestuous linking to the Red Star Mother Ship.... I say: they wear pink rhinestone collars and leashes and the leashes lead straight back to the party. Yes yes yes: they are "Democratic" sites. They surely do coordinate. Rahm, Reid, Hillpac, Schumer, Rendell, others. The conservative Democrats, red states, blue states, purple ...
ACCA Revision Series: Managing People Paper 1.3 by ACCA, 9780748353071, available at Book Depository with free delivery worldwide.
Residues 6 to 308 (E-value = 1.6e-11) place CPn0297 in the Acyl_transf_1 family which is described as Acyl transferase domain (PF00698 ...
From BioPortfolio: MORRISVILLE, N.C., March 03, 2017 (GLOBE NEWSWIRE) -- Novan, Inc. (“the Company” or “Novan”) (NASDAQ:NOVN) today announced that the Comp...
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Novartis (VTX:NOVN) has been given a CHF 92 price target by analysts at Morgan Stanley in a report issued on Friday. The firm presently has a
1A6X: Structure of the carboxy-terminal fragment of the apo-biotin carboxyl carrier subunit of Escherichia coli acetyl-CoA carboxylase.
Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503 ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Mediastinoskopi uygulandığı ilk yıllarda etyolojisi belirsiz mediastinal proçeslerde % 90 ve akciğer parankim proçeslerinde % 50lik bir diagnostik yararlanımın gösterilmesi üzerine, toraks cerrahisinde kısa sürede ilgi gördü[3,4]. Bu diagnostik tekniğin malign toraks hastalıklarında özellikle bronş karsinomlarında prognostik değerlendirme ve evreleme amacıyla kullanımının yaygınlaşması üzerine, 1949 yılında Daniels tarafından tarif edilmiş olan skalenlenf nodu biyopsi uygulamaları, palpabl lenf düğümleri dışında yerini tamamen mediastinoskopiye bıraktı[4,5].. Soliter kitlelerden çok diffüz mediastinal lenfadenopatilerle kendini gösteren lenfatik sistemin hastalıkları (sarkoidozis, hodgkin ve nonhodgkin lenfomalar, tüberküloz lenfadenopatiler gibi) tanısının koyulmasında mediastinoskopinin vazgeçilmez bir yeri vardır. Maassen ve Greschuchnanın diferansiyel diagnostik amaçla yaptıkları 1076 mediastinoskopinin 887sinden (%82.4) sonuç ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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Some things included on an accident report form include details about the accident, people and vehicles involved and a list of witnesses, says NOLO. It may also include photographs and a diagram of...
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A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST ...
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International Accounting Standard IAS 41, Agriculture, is the first standard that specifically covers the primary sector. The Standard becomes operative for annual financial statements covering periods beginning on or after 1 January 2003 with earlier application encouraged.
You could tell that Charlie Ward is all keyed up over the approaching FSU-Florida game because he was speaking almost loud enough to be heard.The gifted, but remarkably unaffected FSU quarterback
Ive seen this bag featured as the new It bag in more magazines than I can count... Harpers (I think) even did a huge spread on how it would...
In the end, much of the hype surrounding the FCCs meeting this week amounted to nothing. After a delay of almost 12-hours, the meeting opened with a diminished...
As of now it appears all the hype over the Swine Flu maybe not pan out to meet the news agencies expectations but lessons learned here can and should be
In the linear pathway (Figure 1A), GLU is converted to acetylglutamate (Ac-GLU) by N-acetylglutamate synthase (NAGS, encoded by argA) which is inhibited by ARG through negative feedback regulation [36],[39]. Sequential catalytic reactions catalyzed by the next three enzymes, N-acetylglutamate kinase (NAGK, encoded by argB), N-acetylglutamate semialdehyde dehydrogenase (encoded by argC) and N-acetylornithine transaminase (encoded by argD), which are common in the three pathways (Figure 1), yield N-acetylornithine (Ac-ORN) [34]. The next step, which distinguishes the linear pathway from the other two pathways, is deacetylation of Ac-ORN by AOase to yield ORN [40],[41]. The next and final steps are carried out by ornithine carbamoyltransferase (OTC or OTCase, encoded by argF), argininosuccinate synthase (encoded by argG) and argininosuccinate lyase (encoded by argH), which finally yield ARG [35]. This pathway has been found in a few species such as Myxococcus xanthus [41] and E. coli [36].. In many ...
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One subfamily of guanidino group-modifying enzymes (GMEs) consists of the agmatine deiminases (AgDs). These enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia. In plants, viruses, and bacteria, these enzymes are thought to be involved in energy production, biosynthesis of polyamines, and biofilm formation. In particular, we are interested in the role that this enzyme plays in pathogenic bacteria. Previously, we reported the initial kinetic characterization of the agmatine deiminase from Helicobacter pylori and described the synthesis and characterization the two most potent AgD inactivators. Herein, we have expanded our initial efforts to characterize the catalytic mechanisms of AgD from H. pylori as well as Streptococcus mutans and Porphyromonas gingivalis. Through the use of pH rate profiles, pK(a) measurements of the active site cysteine, solvent isotope effects, and solvent viscosity effects, we have determined that the AgDs, like PADs 1 and 4
You searched for: Product Keywords amphetamine sulfate tablets Remove constraint Product Keywords: amphetamine sulfate tablets Collections Drugs and Devices, 1940-1963 Remove constraint Collections: Drugs and Devices, 1940-1963 Titles 3948. Misbranding of amphetamine sulfate tablets. U. S. v. Hy-Gold Drug Co., Inc., and Boris Golden. Pleas of nolo contendere. Fine of $200 against corporation and $100 against individual. Remove constraint Titles: 3948. Misbranding of amphetamine sulfate tablets. U. S. v. Hy-Gold Drug Co., Inc., and Boris Golden. Pleas of nolo contendere. Fine of $200 against corporation and $100 against individual. ...
The Phase 1b clinical trial is being conducted in 48 adults with mild-to-moderate atopic dermatitis with up to 30% body surface area at baseline. Two concentrations of SB414 and vehicle cream, applied twice-daily for two weeks, are being evaluated for safety, for systemic exposure and to assess target engagement through a reduction of key pro-inflammatory biomarkers such as interleukin-4, or IL-4, before progressing to Phase 2 clinical trials. Eczema area severity index (EASI) scores are also being recorded at baseline and at the end of treatment. Top line results are targeted for the third quarter of 2018.. "Atopic dermatitis is a common and upsetting skin disease that is in need of more effective and safe treatments," stated Lisa A. Beck, M.D., professor, Department of Dermatology, University of Rochester School of Medicine. "The topical products currently available target only one aspect of the disease pathology, the inflammation. We recognize that skin colonization with Staphylococcus aureus ...
07/17/2017 Pace University, ACCA USA, to Train Finance Professionals to Stymie Cyberattacks this Summer. New York, N.Y. -ACCA USA (the Association of Chartered Certified Accountants), the global body for professional accountants, and the Seidenberg School of Computer Science and Information Systems at Pace University in New York, a National Security Agency and Department of Homeland Security-certified Center of Academic Excellence in Information Assurance Education, today unveiled their first-ever cyberdefense course.. The course-which will be held on August 4 at Pace in Lower Manhattan-will provide professional development credits to accountants and other finance industry professionals. It was designed in the wake of an increasing pattern of cyberattacks that have struck private and public entities here in the United States and abroad.. "ACCA understands the challenges that accountants face and is determined to provide them with the necessary knowledge and training to address these ...
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KNOW Bio, LLC, a company created in late 2015 from the separation of all non- dermatological assets from Novan, Inc (NASDAQ: NOVN) , announces the hiring of Anne Clem Whitaker
Business Leadership South Africa CEO Busisiwe Mavuso ACCA proclaims the message as loudly as she can: leadership failure is the most serious organisational failure of all
Dr. Patrick Soon-Shiong, a biotech billionaire, launched a moonshot to vanquish cancer. But a STAT investigation found the hype far outruns the progress.
It is claimed that honey can prevent, treat and cure all manner of ailments to from acne to worms! But how much is true and how much is just hype?
Read more about Mihir S Sharma: Unpacking the Modi Hype on Business Standard. Few words in the English language are as evasive as
I'm an international student, came to uk to study towards my accountancy qualification ACCA at BPP University. Which is - Answered by a verified Solicitor
I think it is useful to recall the relevant historical timeline.. The connection between axial-gravitational anomaly and transport (in flat space) at finite temperature, zero chemical potential was first suggested in a paper by Landsteiner, Megías, and Pena-Benitez, https://arxiv.org/abs/1103.5006. The effect was first pointed out to be possible by Neiman and Oz (arXiv:1011.5107). Landsteiner et al. suggested that the coefficient of this effect is equal to the coefficient of axial-gravitational anomaly, multiplied by temperature squared. How did they know? They constructed a simple theory in AdS5 so that the corresponding CFT4 has an axial-gravitational anomaly. Then they considered a black-brane solution, and by using AdS/CFT, found a "chiral vortical" coefficient proportional to the coefficient of the axial-gravitational anomaly.. I remember being very perplexed by the claimed connection between transport in flat space and anomaly in curved space appeared to me very strange. Not only that ...
I had a good chuckle over the new content at Microsofts Open XML Community web site. Please take a look. What it lacks in accuracy it makes up for in the
This years version of the Toronto Blue Jays has a buzz around it like I havent felt in quite some time. Alex Anthopoulos has reignited a spark that became the norm in the late 80s and early 90s...
Corn futures lost ground today after yesterdays sell-off. Late last year the crop hit 10-year highs on speculation that ethanol demand would spike. Now a report from the Earth Policy Institute says that demand has been vastly understated. The result could be the highest grain prices in history.
I have been doing alot of reading and comparing lately. Much more than I used to do when falling for any hype. So far I havent seen much if any
No Hype - just the Facts. Your complete source of news and realtime quotes from the TSX, TSX-V, CSE, Montreal, Nasdaq, NYSE, Amex and OTC Markets.
No Hype - just the Facts. Your complete source of news and realtime quotes from the TSX, TSX-V, CSE, Montreal, Nasdaq, NYSE, Amex and OTC Markets.
It seems like everything these days is considered a superfood, so we decided to look into which of these foods are actually research-backed and which ones are all hype.
Does it live up to the hype? What makes Megawatt HD by 1st Phorm any different than your other pre-workouts? Click here to learn more and hear our opinion.
Black Note E-liquid Review - We take a look at the premium NET (naturally extracted tobacco) e-juice by Black Note and see if they can live up to the hype!
Biotin Carboxyl Carrier Protein is on Rediff pages, ,Follow Biotin Carboxyl Carrier Protein to get latest updates from Biotin Carboxyl Carrier Protein
As the spread of antibiotic resistant bacteria steadily increases, there is an urgent need for new antibacterial agents. Because fatty acid synthesis is only used for membrane biogenesis in bacteria, the enzymes in this pathway are attractive targets for antibacterial agent development. Acetyl-CoA carboxylase catalyzes the committed and regulated step in fatty acid synthesis. In bacteria, the enzyme is composed of three distinct protein components: biotin carboxylase, biotin carboxyl carrier protein, and carboxyltransferase. Fragment-based screening revealed that amino-oxazole inhibits biotin carboxylase activity and also exhibits antibacterial activity against Gram-negative organisms. In this report, we redesigned previously identified lead inhibitors to expand the spectrum of bacteria sensitive to the amino-oxazole derivatives by including Gram-positive species. Using 9,411 small organic building blocks, we constructed a diverse combinatorial library of 1.2 × 108 amino-oxazole derivatives. A subset
Kinetic studies were performed on the superoxide dismutases isolated from the anaerobic bacterium Propionibacterium shermanii as active enzymes with either iron or manganese, which were naturally incorporated into the same molecule depending on the metal supply. Both the Fe- and Mn- forms showed decreasing activity with increasing pH. This suggests the protonation of some groups near the metal, possibly a metal-bound water molecule. Thus the kinetic behaviour of this superoxide dismutase is much more dependent on the protein structure than on the metal incorporated into the active site. The secondary structures of both forms were not influenced by variations in pH, whereas the EPR spectra of the Fe-superoxide dismutase changed as a function of pH. The EPR spectra apparently consist of two overlapping species. Steady-state experiments proved that all iron-containing species show catalytic activity, but the species predominating in the alkaline pH range displays a lower reaction rate. The ...
Looking for biotin carboxylase? Find out information about biotin carboxylase. An enzyme which condenses bicarbonate with biotin to form carboxybiotin Explanation of biotin carboxylase
Accepted name: methylmalonyl-CoA decarboxylase. Reaction: (S)-methylmalonyl-CoA = propanoyl-CoA + CO2. Other name(s): propionyl-CoA carboxylase (incorrect); propionyl coenzyme A carboxylase (incorrect); methylmalonyl-coenzyme A decarboxylase; (S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase (incorrect); (S)-methylmalonyl-CoA carboxy-lyase. Systematic name: (S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming). Comments: The enzyme from Veillonella alcalescens is a biotinyl-protein, requires Na+ and acts as a sodium pump.. Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-44-4. References:. 1. Galivan, J.H. and Allen, S.H.G. Methylmalonyl coenzyme A decarboxylase. Its role in succinate decarboxylation by Micrococcus lactilyticus. J. Biol. Chem. 243 (1968) 1253-1261. [PMID: 5646172]. 2. Hilpert, W. and Dimroth, P. Conversion of the chemical energy of methylmalonyl-CoA decarboxylation into a Na+ gradient. Nature 296 (1982) 584-585. [PMID: 7070502]. 3. ...
K11263 bccA; acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14 ...
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Haller et al. [23] suggested that the sbm operon provides an alternative succinate dissimilation pathway to PA. This would require that E. coli mutase (ScpA), unlike other known mutases [24], would produce the (S)-enantiomer of methylmalonyl-CoA directly or that the methylmalonyl-CoA decarboxylase acts on the (R)-enantiomer (Fig. 1). The authors were unable to directly validate this claim as their HPLC method was unable to distinguish between the (R) and (S)-enantiomer of methylmalonyl-CoA. However, they did provide indirect evidence through a coupled assay of ScpA and ScpB that it was operational. Other studies have concluded that ScpA is similar to most mutases and can only catalyse the conversion between succinyl-CoA and the (R)-methylmalonyl-CoA enantiomer. Dayem et al. [25] confirmed initial results from Vallari et al. [39] that E. coli does not produce the (S)-methylmalonyl CoA enantiomer [40]. More recently, Li et al. [22] engineered a succinate producing strain T110 and expressed the sbm ...
What is the current status of gene therapy research?. The Food and Drug Administration (FDA) has not yet approved any human gene therapy product for sale. Current gene therapy is experimental and has not proven very successful in clinical trials. Little progress has been made since the first gene therapy clinical trial began in 1990. In 1999, gene therapy suffered a major setback with the death of 18-year-old Jesse Gelsinger. Jesse was participating in a gene therapy trial for ornithine transcarboxylase deficiency (OTCD). He died from multiple organ failures 4 days after starting the treatment. His death is believed to have been triggered by a severe immune response to the adenovirus carrier.. Another major blow came in January 2003, when the FDA placed a temporary halt on all gene therapy trials using retroviral vectors in blood stem cells. FDA took this action after it learned that a second child treated in a French gene therapy trial had developed a leukemia-like condition. Both this child ...
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Rabbit polyclonal Ornithine Carbamoyltransferase antibody validated for WB and tested in Mouse. Immunogen corresponding to synthetic peptide
Nowadays, everyone in the gym is a trainer and considers themselves an expert in the field of fitness because they have acquired two muscles. Know the facts and dont believe the hype.
Ive been on this board for more than 8 months. When I first joined, Green Irish Tweed was the favorite horse. But soon after, people started shifting to Creeds Aventus. It soon became, easily, the most acclaimed fragrance on Basenotes. For the past few months, it has been in a lot of top 10 lists, the center of a lot of topics, and in nearly every topic asking for suggestions, someone is going to mention Aventus. Ive never seen this much hype in a fragrance before, ever. Aventus has
Hype & Hope is an information and education channel focused on key issues within the life sciences. We provide news, events, editorial, stock indices, video, and image libraries on issues including stem cells, personalized medicine, and clinical trials.
We dont need to oversell research findings. Science is cool enough - and, in the case of last weeks Mediterranean Diet study, tasty enough to withstand the rigors of discovery without the hype. - Michael Yudell, Philadelphia Inquirer
A recent systematic review of the alleged health benefits of curcumin show that, yet again, hype based on traditional use is not a reliable guide. Curcumin...
Achten, W.M.J., Maes, W.H., Aerts, R., Verchot, L.V., Trabucco, A., Mathijs, E., Singh, V.P., Muys, B. 2010. Jatropha: from global hype to local opportunity . Journal of Arid Environments 74 (1) :164-165. ISSN: 0140-1963 ...
Hype Williams get a pretty headstone with the Rainbow Edition, hustling 20 joints strictly for the whip …& ppl 2 fat for fedoras. Trust its a suitably smoked
Acca Kappa combs are designed to protect the hairs natural beauty by reducing damage and breakage to hair. They are unique in both natural beauty and design. *Size:* 7.6
Sadly, its not just VMWare. Even supposedly independent research organizations like Gartner are trumpeting the cloud as loudly as they can these days. Then again, these are the very same people that were at the forefront of the SOA, etc hype too :-).. The technology industry overall seems to hold the unfortunate belief that overblown marketing is an essential tool to "sell" anything -- even things that do indeed have technical merit. Guess thats where TSS steps in to separate the reality from the hype :-). Fortunately rank-and-file developers in general seem to grasp the concept of the hype cycle. Its the "higher-ups" in the technology organizations that often dont seem to get it.... ...
Re. Editorial: It's important to immunize, (Aug. 29): I'm a native of Newport Beach, but live in Washington, D.C. I'm glad the Daily Pilot has sided with overwhelming scientific evidence showing that the benefits of vaccinating children far outweigh the risks. Vaccines help save lives. Period....
Well, Live Earth is over and I cant say I feel any different. It didnt really seem to have the impact to compliment the hype they were trying to put behind it. Maybe the key word is to try. Perhaps the hype was less than successful or the talent wasnt really there compared to similar festivals of the past. There was
The problem with hype is that its all too often unchallenged: too many people go with the sound of the appealing words/phrases and dont investigate the context, the meaning that the words/phrases are selling (and hype IS a sales tactic, materially and contextually).. I dont know any of these persons in any way except as to the contradictory tales being told about them and by them about the rest. But I (so far) havent read any context as to why, say, in this instance, this guy, "Ali," is being said to be doing such good things when, instead, I read what he actually says and its disappointing to read, at best. So it just seems to me that "the proof is in the pudding," to use a colloquialism, which means, when you want answers as to quality and more, they can usually be found in the context to which any recipe refers.. How ANYone can not have ever heard LIVE AT THE FILMORE EAST is beyond me, so theres that, too.. Sometimes just telling people to "STheckUP" as I did recently in a tweet sums up ...
Bandana asks…Since Ive been trying to get pregnant over the last year, Ive become more concerned about toxicity. I probably eat a sizeable amount o
In 1990 The New York Times published a front-page article by Lawrence Altman, a reporter with a medical degree, announcing that scientists had discovered “a link between alcoholism and a specific gene.” That was merely one in a string of reports in which the Times and other major media hyped what turned out to be [...]
Which classic 90s game have we been asking to be remade, and has yet only had a dodgy FPS to its name in recent years? Was it a game programmed by this man?
Pear, a juicy, sweet, and aromatic fruit, is available in many varieties, with countless nuances of shape and color. A harmonious fragrance whose traditional si
MetabolismPurines, pyrimidines, nucleosides, and nucleotidesPyrimidine ribonucleotide biosynthesisaspartate carbamoyltransferase (TIGR00670; EC 2.1.3.2; HMM-score: 120.5) ...
Bank Transfer Day was lauded for helping to nudge consumers toward credit unions. It was belittled as mere media hype. It was feared it would only bring in deposits and not loans, which would tip delicately balanced capital ratios.
As the hype and froth begins to settle, the true potential of algal biofuels is starting to slowly rise from the depths. Simon Evans reports on progress
Alright starting another log. I was lucky enough to be chosen by BPS to log some EndoSurge and then AI chose me to log Stoked and Agmatine. Pretty
Propionyl-coenzyme A carboxylase (PCC), a mitochondrial biotin-dependent enzyme, is essential for the catabolism of the amino acids Thr, Val, Ile and Met, cholesterol and fatty acids with an odd number of carbon atoms. Deficiencies in PCC activity in humans are linked to the disease propionic acidaemia, an autosomal recessive disorder that can be fatal in infants. The holoenzyme of PCC is an alpha(6)beta(6) dodecamer, with a molecular mass of 750 kDa. The alpha-subunit contains the biotin carboxylase (BC) and biotin carboxyl carrier protein (BCCP) domains, whereas the beta-subunit supplies the carboxyltransferase (CT) activity. Here we report the crystal structure at 3.2-A resolution of a bacterial PCC alpha(6)beta(6) holoenzyme as well as cryo-electron microscopy (cryo-EM) reconstruction at 15-A resolution demonstrating a similar structure for human PCC. The structure defines the overall architecture of PCC and reveals unexpectedly that the alpha-subunits are arranged as monomers in the holoenzyme,
Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5-adenylate (BirA-bio- 5-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon (319 aa ...
4-(IMIDAZOL-1-YL)ACETOPHENONE 10041-06-2 NMR spectrum, 4-(IMIDAZOL-1-YL)ACETOPHENONE H-NMR spectral analysis, 4-(IMIDAZOL-1-YL)ACETOPHENONE C-NMR spectral analysis ect.
This model finds the subfamily of distantly related, low complexity, hydrophobic small subunits of several related sodium ion-pumping decarboxylases. These include oxaloacetate decarboxylase gamma subunit and methylmalonyl-CoA decarboxylase delta subunit. Most sequences scoring between the noise and trusted cutoffs are eukaryotic sodium channel proteins ...
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Copyright © 2017 Nolo ® Self-help services may not be permitted in all states. The information provided on this site is not legal advice, does not constitute a lawyer referral service, and no attorney-client or confidential relationship is or will be formed by use of the site. The attorney listings on this site are paid attorney advertising. In some states, the information on this website may be considered a lawyer referral service. Please reference the Terms of Use and the Supplemental Terms for specific information related to your state.Your use of this website constitutes acceptance of the Terms of Use, Supplemental Terms, Privacy Policy and Cookie Policy. 7031 Koll Center Pkwy, Pleasanton, CA 94566. ...
Background Checks All admitted students will be required to undergo a fingerprint background check before beginning the clinical portion of the Radiography Program. The background check will be coordinated by the Health Professions Office. The cost of the procedure is covered in the Radiography Program summer course fees.. A student with a positive background check including misdemeanors or felony offenses including convictions or charges resulting in a plea of guilty, plea of nolo contendere (no contest), withheld or deferred adjudication, suspended or stay of sentence, pre-trial diversion activity, or military court-martial will not be allowed to enter the clinical portion of the program until the American Registry of Radiologic Technologists Pre-Application Review Process (ARRT , Ethics , Pre-Application Process) has been completed and clearance from the ARRT Ethics committee has been obtained. If students have proof that theyve completed a fingerprint background check within the last 12 ...
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Holocarboxylase synthetase (HCS, human) and BirA (Escherichia coli) are biotin protein ligases that catalyze the ATP-dependent attachment of biotin to apocarboxylases. Biotin attachment occurs on a highly conserved lysine residue within a consensus sequence (Ala/Val-Met-Lys-Met) that is found in carboxylases in most organisms. Numerous studies have indicated that HCS and BirA, as well as biotin protein ligases from other organisms, can attach biotin to apocarboxylases from different organisms, indicating that the mechanism of biotin attachment is well conserved. In this study, we examined the cross-reactivity of biotin attachment between human and bacterial biotin ligases by comparing biotinylation of p-67 and BCCP87, the biotin-attachment domain fragments from human propionyl-CoA carboxylase and E. coli acetyl-CoA carboxylase, respectively. While BirA has similar biotinylation activity toward the two substrates, HCS has reduced activity toward bacterial BCCP87 relative to its native substrate, p-67.
1. The major free lipids of Corynebacterium aquaticum were characterized as dimannosyl diglyceride, monomannophosphoinositide and phosphatidylethanolamine. Bisphosphatidylglycerol and phosphatidylglycerol were also tentatively identified. 2. We regard this as the only well-documented case of an organism containing monomannophosphoinositide to the exclusion of dimannophosphoinositides and the higher homologues. 3. The co-existence of the two mannolipids in one organism is a distinctive feature. So also is the presence of phosphatidylethanolamine in a corynebacterium. 4. The monomannophosphoinositide apparently does not utilize phosphatidylinositol as a precursor, unlike the monomannophosphoinositide of Propionibacterium shermanii. CDP-diglyceride may be necessary for its synthesis.. ...
The post infectious paralytic autoimmune disease, Guillain-Barré syndrome (GBS), has been associated with the generation of cross-reactive auto-antibodies after Campylobacter jejuni infection. These auto-antibodies interact with both the ganglioside mimicking C. jejuni lipo-oligosaccharides (LOS) and endogenous gangliosides. This study sought to investigate novel interactions of the ganglioside mimicking LOS with immune system ganglioside specific receptors. In addition, studies investigated if such receptor recognition affects antigen trafficking or the immunostimulatory potency of the LOS, which could participate in auto-antibody generation. Results presented in this thesis demonstrate for the first time that certain members of the siglec receptor family are capable of recognising LOS from a GBS associated strain of C. jejuni. This interaction did not definitively result in enhanced, or altered, potency of ganglioside mimicking LOS in stimulating immune cells. Interestingly, ganglioside ...
Gratuit 31 Famous Quotations Youve Been Getting Wrong Thought ... Whether its a Facebook status or a bumper sticker, everyone loves a great quote. However, some of the most famous quotes in history, from Gandhi to Mark Twain, aren ... Next step for Predators: Getting beyond second round FOX ... Weve got a lot of work to do, Predators coach Peter Laviolette said Thursday night after a 4 1 victory that completed the stunning sweep of Chicago. Getting New Charitable Donors For Your Nonprofit Nolo.com Individual donors are crucial to the fundraising success of most nonprofits. But finding new donors is among every nonprofit organizations biggest challenges. Taleo Enterprise Taleo Reporting Getting Started with ... Getting Started with Business Objects XI3.1 User Guide Recruiting 12A ii Confidential Information and Notices Confidential Information The recipient of this ... 4. Getting started: first steps in policy development Getting started: first steps in policy development 23 A participatory ...

Transferases | definition of transferases by Medical dictionaryTransferases | definition of transferases by Medical dictionary

... transferases explanation free. What is transferases? Meaning of transferases medical term. What does transferases mean? ... Looking for online definition of transferases in the Medical Dictionary? ... carboxyl- and carbamoyltransferases, 2.1.3; and amidinotransferases, 2.1.4); acyl residues (acyltransferases, 2.3); glycosyl ... transferases. Also found in: Dictionary, Thesaurus, Encyclopedia.. Related to transferases: Lyases, Ligases, Hydrolases, ...
more infohttps://medical-dictionary.thefreedictionary.com/transferases

CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations 
      -...CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations -...

102000007132 Carboxyl and Carbamoyl Transferases Human genes 0 description 1 * 108010072957 Carboxyl and Carbamoyl Transferases ... 108010031311 Intramolecular Transferases Proteins 0 description 1 * 102000005385 Intramolecular Transferases Human genes 0 ... 108010077385 Coenzyme A-Transferases Proteins 0 description 1 * 102000010079 Coenzyme A-Transferases Human genes 0 description ...
more infohttps://patents.google.com/patent/CA2426774A1/en

US Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.comUS Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.com

... and related transferases 2.1.3 Carboxyl- and carbamoyltransferases 2.1.4 Amidinotransferases 2.2 Transferring aldehydic or ... aldolyase 4.2.1 Hydro-lyases 1. carbonic anhydrase 5. Isomerase 5.4 Intramolecular transferases 5.4.2 Transferring phosphoryl ... Transferases, Class 4 Lyases and Class 5, Isomerases, can also be of interest in particular situations. The following table has ... Transferases 2.7 Transferring phosphorus-containing groups 2.7.1 Phosphotransferases with CH--OH as acceptor 1. hexokinase 2. ...
more infohttp://patents.com/us-4299916.html

List of MeSH codes (D08) - WikipediaList of MeSH codes (D08) - Wikipedia

... carboxyl and carbamoyl transferases MeSH D08.811.913.555.275.200 --- aspartate carbamoyltransferase MeSH D08.811.913.555. ... glutathione transferase MeSH D08.811.913.225.500.500 --- glutathione S-transferase pi MeSH D08.811.913.225.575 --- ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 --- carbon-nitrogen ligases with glutamine as amide-n-donor ... carboxyl group acceptor) MeSH D08.811.913.696.630.025 --- acetate kinase MeSH D08.811.913.696.630.050 --- aspartate kinase MeSH ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.  - PubMed - NCBIToxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity. - PubMed - NCBI

Carboxyl and Carbamoyl Transferases/chemistry*. *Carboxyl and Carbamoyl Transferases/genetics. *Carboxyl and Carbamoyl ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/25079908?dopt=Abstract

Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamilyCarbamoyl phosphate synthetase, small subunit N-terminal domain superfamily

The SCOP classification for the Carbamoyl phosphate synthetase, small subunit N-terminal domain superfamily including the ... Transferases. 1. 0. --. INHERITED FROM: Carboxyl- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ... Carboxyl- and carbamoyltransferases. 0.000002517. Highly Informative. Direct. Document: EC annotation of SCOP domains. Enzyme ... Transferases. 1. 0.301. --. INHERITED FROM: Aspartate carbamoyltransferase ,, Carboxy- and carbamoyltransferases. Enzyme ...
more infohttp://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52021

Carbamoyl phosphate synthetase, large subunit connection domain superfamilyCarbamoyl phosphate synthetase, large subunit connection domain superfamily

The SCOP classification for the Carbamoyl phosphate synthetase, large subunit connection domain superfamily including the ... Transferases. 1. 0. --. INHERITED FROM: Carboxyl- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ... Carboxyl- and carbamoyltransferases. 0.00001407. Highly Informative. Direct. Document: EC annotation of SCOP domains. Enzyme ... Transferases. 1. 0.302. --. INHERITED FROM: Carboxy- and carbamoyltransferases ,, Aspartate carbamoyltransferase. Enzyme ...
more infohttp://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?sunid=48108

Methylglyoxal synthase-like superfamilyMethylglyoxal synthase-like superfamily

Carboxyl- and carbamoyltransferases. 1. Highly Informative. Inherited. Enzyme Commission (EC). In cyclic amides. 1. Highly ... Hydroxymethyl-, formyl- and related transferases. 0. 1.356. Informative. DIRECT. Enzyme Commission (EC). Carbamoyl-phosphate ... Carbamoyl-phosphate synthase (ammonia). 0.0000000000225. 2.233. Highly Informative. DIRECT. Enzyme Commission (EC). Carboxyl- ... Hydroxymethyl-, formyl- and related transferases. 0. Informative. Direct. Enzyme Commission (EC). Carbamoyl-phosphate synthase ...
more infohttp://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF52335

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Carboxyl and Carbamoyl Transferases - toxicity , Long-Term Potentiation - drug effects , Neurons - physiology , Escherichia ... Carboxyl and Carbamoyl Transferases - chemistry , Index Medicus ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:SECRETED%20OLIGOMERS

ABP73856.1 protein (Shewanella putrefaciens) - STRING interaction networkABP73856.1 protein (Shewanella putrefaciens) - STRING interaction network

... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase. PFAM- phospholipid/glycerol ... PFAM- biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl- ... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase (1517 aa) ... carboxyl transferase subunit alpha/carboxyl transferase subunit beta/biotin carboxylase ...
more infohttps://string-db.org/network/319224.Sputcn32_0120

Noca 4502 protein (Nocardioides sp. JS614) - STRING interaction networkNoca 4502 protein (Nocardioides sp. JS614) - STRING interaction network

Carboxyl transferase (497 aa). Predicted Functional Partners:. Noca_4551. Carbamoyl-phosphate synthase subunit L (633 aa) ...
more infohttps://string-db.org/network/196162.Noca_4502

Aspartates | definition of aspartates by Medical dictionaryAspartates | definition of aspartates by Medical dictionary

aspartate carbamoyl transferase. enzyme catalyzing the condensation of carbamoyl phosphate and l-aspartate to N-carbamoyl-l- ... It has an extra carboxyl group and is therefore acidic in solution. The ISOELECTRIC POINT of aspartic acid is 2.8.. as·par·tate ...
more infohttps://medical-dictionary.thefreedictionary.com/aspartates

Ribonucleotide - WikipediaRibonucleotide - Wikipedia

Orotate is covalently linked with phosphoribosyl pyrophosphate (PRPP) by orotate phosphoribysol-transferase yielding orotidine ... A carboxyl group is attached to AIR by N5-CAIR synthetase to form N5-Carboxyaminoimidazole ribonucleotide (N5-CAIR), which is ... ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl ...
more infohttps://en.wikipedia.org/wiki/Ribonucleotide

Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full TextGenome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full Text

As a specific example of this process, consider the reaction corresponding to carbamoyl-phosphate synthase (R_CBPS), EC 6.3. ... carboxyl transferase. A0RY61. 8.00E-169. 6.3.4.14. biotin carboxylase. Cthe_0949 ... We found two C. thermocellum genes annotated as "carbamoyl-phosphate synthase, small subunit" (Cthe_1867, Cthe_0950) and two ... a small glutamine-hydrolyzing chain and a large chain that synthesizes carbamoyl phosphate. ...
more infohttps://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-31

METHODS AND COMPOSITIONS FOR ISOLATING, IDENTIFYING AND CHARACTERIZING     MONOCOT PLASTIDIC ACCASE HERBICIDE TOLERANT...METHODS AND COMPOSITIONS FOR ISOLATING, IDENTIFYING AND CHARACTERIZING MONOCOT PLASTIDIC ACCASE HERBICIDE TOLERANT...

0157] Region 8: pfam01039 (Carboxyl_trans) Carboxyl transferase domain (of biotin-dependent carboxylases). [0158] The carboxyl ... 0151] Region 3: pfam02786 (CPSase_L_D2) Carbamoyl-phosphate synthase L chain, ATP binding domain; [0152] Region 4: pfam02785 ( ... 0128] As used herein, and "herbicide sensitivity region" (HSR) is an amino acid sequence present in the carboxyl transferase ... 0159] Region 8 comprises the carboxyl transferase domain of the ACCase enzyme of the invention. Herbicide sensitivity has been ...
more infohttp://www.patentsencyclopedia.com/app/20140377835

The use of proteomic techniques to study the physiology and virulence of  staphylococcus aureus The use of proteomic techniques to study the physiology and virulence of staphylococcus aureus

... carboxyl transferase, beta subunit (accD) SACOL1748 3 sdrC protein (sdrC) SACOL0608 2 Staphylococcus aureus sex pheromone (camS ... PUR9 18 6 Carbamoyl phosphate synthase large chain Q5HGM9,CARB 12 12 Probable thiol peroxidase Q5HF61,TPX 14 7 Chaperone ... DEF 0 2 Acetyl coenzyme A carboxylase carboxyl transferase subunit alpha Q5HF74,ACCA 3 0 UDP N acetylmuramoylalanine -D ... PTPA 5 2 Acetyl coenzyme A carboxylase carboxyl transferase subunit beta Q5HF73,ACCD 4 4 GTP sensing transcriptional ...
more infohttp://digital.lib.usf.edu/SFS0028061/00001

Neoblast data searchNeoblast data search

Mlig032628.g4 {Length: 2316} {Pfam: Carboxyl transferase domain [PF01039.20, score=633.8]; Malonate decarboxylase gamma subunit ... Mlig032858.g3 {Length: 2904} {TRANSSPLICED} {Pfam: Carbamoyl-phosphate synthase L chain, ATP binding domain [PF02786.15, score= ... Mlig032628.g3 {Length: 2337} {TRANSSPLICED} {Pfam: Carboxyl transferase domain [PF01039.20, score=633.8]; Malonate ... Mlig032628.g2 {Length: 2337} {TRANSSPLICED} {Pfam: Carboxyl transferase domain [PF01039.20, score=633.8]; Malonate ...
more infohttp://neoblast2.macgenome.org/searchgene?gc=29

KEGG SSDB Best Search Result: mja:MJ 0414KEGG SSDB Best Search Result: mja:MJ 0414

vat:B7L28_03625 glycosyl transferase K02843 345 100 ( -) 29 0.313 67 ,-, 1 xbo:XBJ1_2503 pyruvate kinase I (formerly F), ... pmi:PMT9312_0975 carbamoyl-phosphate synthase large sub K01955 1098 105 ( -) 30 0.305 82 -, 1 pvx:PVX_083330 hypothetical ... ehi:EHI_158580 ubiquitin carboxyl-terminal hydrolase do 1298 112 ( -) 31 0.308 91 -, 1 fro:AALO17_10210 GTP pyrophosphokinase ... glj:GKIL_4105 glycosyl transferase group 1 414 106 ( -) 30 0.324 68 -, 1 gmx:100801933 pentatricopeptide repeat-containing ...
more infohttp://www.kegg.jp/ssdb-bin/ssdb_best?org_gene=mja:MJ_0414

METHODS FOR MOBILE ZINC MEASUREMENT - MASSACHUSETTS INSTITUTE OF TECHNOLOGYMETHODS FOR MOBILE ZINC MEASUREMENT - MASSACHUSETTS INSTITUTE OF TECHNOLOGY

... carboxyl, nitro, halogen, sulfhydryl, cyano, hydroxyl, carbamoyl and trifluoromethyl; A is -CH2-, -C(═O)-, -C(═S)-, -CH2CH2-, - ... QUINOLINONE FARNESYL TRANSFERASE INHIBITORS FOR THE TREATMENT OF SYNUCLEINOPATHIES AND OTHER INDICATIONS. October, 2009. ... carboxyl (such as -COO−), nitro, halogen, sulfhydryl, cyano, hydroxyl, carbamoyl and trifluoromethyl; ... carboxyl, nitro, halogen, sulfhydryl, cyano, hydroxyl, carbamoyl and trifluoromethyl; ...
more infohttp://www.freepatentsonline.com/y2012/0270262.html

KEGG BRITE: Enzymes - Sinocyclocheilus anshuiensisKEGG BRITE: Enzymes - Sinocyclocheilus anshuiensis

2.1.2 Hydroxymethyl-, formyl- and related transferases 2.1.3 Carboxy- and carbamoyltransferases ... 2.1.1.276 gibberellin A4 carboxyl methyltransferase 2.1.1.277 anthranilate O-methyltransferase 2.1.1.278 indole-3-acetate O- ...
more infohttps://www.kegg.jp/kegg-bin/get_htext?sanh01000+107694947

GO Gene ListGO Gene List

Carboxyl ester lipase. NM_009885. Gene Info. Comt. Catechol-O-methyltransferase. NM_001111062. NM_007744. NM_001111063. Gene ... Glutathione transferase zeta 1 (maleylacetoacetate isomerase). NM_001252555. NM_010363. NM_001252556. Gene Info. ... Carbamoyl-phosphate synthetase 1. NM_001080809. Gene Info. Crot. Carnitine O-octanoyltransferase. NM_023733. Gene Info. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Mm&GOID=0044712

SMART: Secondary literature for Biotin carb C domainSMART: Secondary literature for Biotin carb C domain

In grasses, residues homologous to residues Ile-1,781 and Ile-2,041 in the carboxyl-transferase (CT) domain of the ... Carbamoyl phosphate synthetase (CPS) catalyzes the formation of carbamoyl phosphate from glutamine, bicarbonate, and 2 mol of ... and the carboxyl transferase (CT). Previous data showed that both bacterial and plant BCCP interact with signal transduction ... The carboxyl edges of all four sheets are directed towards the active site region, which lies in a deep crevice. ...
more infohttp://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Biotin_carb_C

NucleotidesNucleotides

Adenine phosphoribosyl transferase (APRT): Adenine + PRPP == AMP + PPi Hypoxanthine-guanine phosphoribosyl transferase: ... The enzyme, carbamoyl phosphate synthetase II, is found in the cytosol; carbamoyl phosphate is also produced in the urea cycle ... The two ions are bridged by an O2- on one side and by the carboxyl group of Glu 115. In close proximity to one of the iron ions ... Each loop connects the carboxyl end of a b-strand with the amino end of an a-helix, the helices being found on the outside of ...
more infohttp://homepages.rpi.edu/~bellos/nucleotides.htm

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full...Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full...

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta. accD (SP_0426). 0 ... Carbamoyl-phosphate synthase large chain. carB (SP_1275). 5. 5. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N- ...
more infohttps://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-11-245
  • 11. The method according to claim 10, wherein said at least one other pharmaceutically active ingredient is chosen from the group consisting of: levodopa, carbidopa-levodopa, dopamine agonists, monoamine oxidase B (MAO-B) inhibitors, catechol-O-methyl transferase (COMT) inhibitors, NMDA receptor antagonists, acetylcholinesterase inhibitors, and mixture thereof. (sumobrain.com)