CarboxyhemoglobinCarbon Monoxide Poisoning: Toxic asphyxiation due to the displacement of oxygen from oxyhemoglobin by carbon monoxide.MethemoglobinCarbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)SulfhemoglobinOximetry: The determination of oxygen-hemoglobin saturation of blood either by withdrawing a sample and passing it through a classical photoelectric oximeter or by electrodes attached to some translucent part of the body like finger, earlobe, or skin fold. It includes non-invasive oxygen monitoring by pulse oximetry.Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Smoke Inhalation Injury: Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)Oxyhemoglobins: A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.Blood Gas Monitoring, Transcutaneous: The noninvasive measurement or determination of the partial pressure (tension) of oxygen and/or carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable of picking up the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin.Dithionite: Dithionite. The dithionous acid ion and its salts.Barium Compounds: Inorganic compounds that contain barium as an integral part of the molecule.Potassium Compounds: Inorganic compounds that contain potassium as an integral part of the molecule.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Spectrophotometry: The art or process of comparing photometrically the relative intensities of the light in different parts of the spectrum.Photolysis: Chemical bond cleavage reactions resulting from absorption of radiant energy.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Erythroblastosis, Fetal: A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.Thiocyanates: Organic derivatives of thiocyanic acid which contain the general formula R-SCN.Seals, Earless: The family Phocidae, suborder PINNIPEDIA, order CARNIVORA, comprising the true seals. They lack external ears and are unable to use their hind flippers to walk. It includes over 18 species including the harp seal, probably the best known seal species in the world.Oceanography: The science that deals with the ocean and its phenomena. (Webster, 3d ed)Pinnipedia: The suborder of aquatic CARNIVORA comprising the WALRUSES; FUR SEALS; SEA LIONS; and EARLESS SEALS. They have fusiform bodies with very short tails and are found on all sea coasts. The offspring are born on land.Lung Diseases: Pathological processes involving any part of the LUNG.Thoracoplasty: Surgical removal of ribs, allowing the chest wall to move inward and collapse a diseased lung. (Dorland, 28th ed)Breath Tests: Any tests done on exhaled air.Emergency Service, Hospital: Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.Child Advocacy: Promotion and protection of the rights of children; frequently through a legal process.Program Evaluation: Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Anemia, Hemolytic: A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).Anemia, Hemolytic, Autoimmune: Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.DNA Copy Number Variations: Stretches of genomic DNA that exist in different multiples between individuals. Many copy number variations have been associated with susceptibility or resistance to disease.Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Comparative Genomic Hybridization: A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.Retinal Vein: Central retinal vein and its tributaries. It runs a short course within the optic nerve and then leaves and empties into the superior ophthalmic vein or cavernous sinus.Pulsatile Flow: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.Illusions: The misinterpretation of a real external, sensory experience.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Pathology, Clinical: A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.Clinical Laboratory Techniques: Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.Laboratories: Facilities equipped to carry out investigative procedures.Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.Optical Devices: Products or parts of products used to detect, manipulate, or analyze light, such as LENSES, refractors, mirrors, filters, prisms, and OPTICAL FIBERS.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Prince Edward Island: An island in the Gulf of St. Lawrence constituting a province of Canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is Charlottetown. Discovered by the French in 1534 and originally named Ile Saint-Jean, it was renamed in 1799 in honor of Prince Edward, fourth son of George III and future father of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p981 & Room, Brewer's Dictionary of Names, 1992, p433)Heart Valve Prosthesis Implantation: Surgical insertion of synthetic material to repair injured or diseased heart valves.Heart Valve Prosthesis: A device that substitutes for a heart valve. It may be composed of biological material (BIOPROSTHESIS) and/or synthetic material.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.EncyclopediasCurrent Procedural Terminology: Descriptive terms and identifying codes for reporting medical services and procedures performed by PHYSICIANS. It is produced by the AMERICAN MEDICAL ASSOCIATION and used in insurance claim reporting for MEDICARE; MEDICAID; and private health insurance programs (From CPT 2002).American Medical Association: Professional society representing the field of medicine.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)United StatesTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Acute Chest Syndrome: Respiratory syndrome characterized by the appearance of a new pulmonary infiltrate on chest x-ray, accompanied by symptoms of fever, cough, chest pain, tachypnea, or DYSPNEA, often seen in patients with SICKLE CELL ANEMIA. Multiple factors (e.g., infection, and pulmonary FAT EMBOLISM) may contribute to the development of the syndrome.Vascular Diseases: Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.Vital Signs: The signs of life that may be monitored or measured, namely pulse rate, respiratory rate, body temperature, and blood pressure.Sulfuric Acids: Inorganic and organic derivatives of sulfuric acid (H2SO4). The salts and esters of sulfuric acid are known as SULFATES and SULFURIC ACID ESTERS respectively.Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed)Cystathionine gamma-Lyase: A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.Nose Diseases: Disorders of the nose, general or unspecified.Football: A competitive team sport played on a rectangular field. This is the American or Canadian version of the game and also includes the form known as rugby. It does not include non-North American football (= SOCCER).Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Senna Plant: A plant genus of the family FABACEAE. SENNA EXTRACT is obtained from members of this genus. Members contain ANTHRAQUINONES and have been an ingredient in laxatives (CATHARTICS). Many species of the CASSIA genus have been reclassified into this genus. This bush should not be confused with the Cassia tree (CINNAMOMUM).Myxedema: A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.Respiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Leg Dermatoses: A nonspecific term used to denote any cutaneous lesion or group of lesions, or eruptions of any type on the leg. (From Stedman, 25th ed)Los AngelesCardiology: The study of the heart, its physiology, and its functions.Appointments and Schedules: The different methods of scheduling patient visits, appointment systems, individual or group appointments, waiting times, waiting lists for hospitals, walk-in clinics, etc.CaliforniaCardiology Service, Hospital: The hospital department responsible for the administration and provision of diagnostic and therapeutic services for the cardiac patient.Toes: Any one of five terminal digits of the vertebrate FOOT.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Audiovisual Aids: Auditory and visual instructional materials.Infant, Premature: A human infant born before 37 weeks of GESTATION.Infant, Newborn: An infant during the first month after birth.Stupor: A state of reduced sensibility and response to stimuli which is distinguished from COMA in that the person can be aroused by vigorous and repeated stimulation. The person is still conscious and can make voluntary movements. It can be induced by CENTRAL NERVOUS SYSTEM AGENTS. The word derives from Latin stupere and is related to stunned, stupid, dazed or LETHARGY.Air Pollution, Indoor: The contamination of indoor air.Diagnostic Errors: Incorrect diagnoses after clinical examination or technical diagnostic procedures.Odors: The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)Sputum: Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.Cellulitis: An acute, diffuse, and suppurative inflammation of loose connective tissue, particularly the deep subcutaneous tissues, and sometimes muscle, which is most commonly seen as a result of infection of a wound, ulcer, or other skin lesions.

Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat. (1/461)

Studies were conducted with rats to investigate whether exposure to CO at concentrations frequently found in the environment caused nitric oxide (NO)-mediated vessel wall changes. Exposure to CO at concentrations of 50 parts per million or higher for 1 h increased the concentration of nitrotyrosine in the aorta. Immunologically reactive nitrotyrosine was localized in a discrete fashion along the endothelial lining, and this was inhibited by pretreatment with the NO synthase (NOS) inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME). The CO-induced elevations of aortic nitrotyrosine were not altered by neutropenia or thrombocytopenia, and CO caused no change in the concentration of endothelial NOS. Consequences from NO-derived stress on the vasculature included an enhanced transcapillary efflux of albumin within the first 3 h after CO exposure and leukocyte sequestration that became apparent 18 h after CO exposure. Oxidized plasma low-density lipoprotein was found immediately after CO exposure, but this was not inhibited by L-NAME pretreatment. We conclude that exposure to relatively low CO concentrations can alter vascular status by several mechanisms and that many changes are linked to NO-derived oxidants.  (+info)

High predictive value of red cell volume measurement using carboxy-haemoglobin in a rabbit model of haemorrhage. (2/461)

We have studied the accuracy of blood volume measurements using carbon monoxide (CO)-labelled haemoglobin (COHb) injection and dilution (CO method) by comparing changes in red cell volume (RCV) measured using the CO method and 51Cr-labelled erythrocyte dilution (51Cr method) in a haemorrhage and infusion model in rabbits. RCV was measured repeatedly using the CO method at four different blood volume stages (stages I-IV). At stages I and IV, RCV was measured simultaneously using the 51Cr method. In comparing the sum of the circulating RCV and extracted RCV (SUM RCV) using the CO method, the values were almost equal and there were no significant differences between the values at the four stages. In comparing circulating RCV measured using the CO method and the 51Cr method, mean difference between the two methods was 0.80 (SD 0.76) ml kg-1 or 4.7 (4.6)%, and a positive correlation was observed (r = 0.91). We conclude that the CO method can be used to measure blood volume during perioperative periods in infants because it avoids use of a radioactive tracer, is simple and repeated measurements are possible.  (+info)

A physiological model for predicting carboxyhemoglobin formation from exposure to carbon monoxide in rats. (3/461)

A time-dependent simulation model, based on the Coburn-Forster-Kane equation, was written in Advanced Continuous Simulation Language to predict carboxyhemoglobin (HbCO) formation and dissociation in F-344 rats during and after exposure to 500 parts/million CO for 1 h. Blood-gas analysis and CO-oximetry were performed on samples collected during exposure and off-gassing of CO. Volume displacement plethysmography was used to measure minute ventilation (VE) during exposure. CO diffusing capacity in the lung (DLCO) was also measured. Other model parameters measured in the animals included blood pH, total blood volume, and Hb concentration. Comparisons between model predictions using values for VE, DLCO, and the Haldane coefficient cited in the literature and predictions using measured VE, DLCO, and calculated Haldane coefficient for individual animals were made. General model predictions using values for model parameters derived from the literature agreed with published HbCO values by a factor of 0.987 but failed to simulate experimental data. On average, the general model overpredicted measured HbCO level by nearly 9%. A specific model using the means of measured variables predicted HbCO concentration within a factor of 0.993. When experimentally observed parameter fluctuations were included, the specific model predictions reflected experimental effects on HbCO formation.  (+info)

Neonatal bilirubin production, reflected by carboxyhaemoglobin concentrations, in Down's syndrome. (4/461)

AIM: To determine whether increased bilirubin production, reflected by blood carboxyhaemoglobin (COHb) values, is responsible for hyperbilirubinaemia in cases of Down's syndrome with no obvious cause for excessive jaundice. METHODS: Blood was sampled on the third day of life for COHb, total haemoglobin (tHb), and serum total bilirubin, from 19 consecutively born neonates with Down's syndrome (a subset of 34 term babies), who had developed hyperbilirubinaemia (serum bilirubin >/= 256 micromol), and from 32 term controls. COHb, measured by gas chromatography, was corrected for inspired CO (COHbc) and expressed as a percentage of tHb. RESULTS: Significantly more of the Down's syndrome subset developed hyperbilirubinaemia than the controls (10/19 (52%) vs 7/32 (22%), relative risk 2.4, 95% confidence intervals (CI) 1.10 to 5.26). Third day serum bilirubin values (mean (SD)) were higher in the Down's syndrome neonates than in controls (214 +- 63 micromol/l vs 172 +- 54 micromol/l, respectively, p=0.015). Mean (SD) COHbc values were significantly higher in the Down's syndrome neonates than in controls (0.92 +- 0. 24% vs 0.63 +- 0.17%; p<0.0001). However, Down's syndrome neonates who became hyperbilirubinaemic had similar COHbc values to those who did not (0.87 +- 0.26% and 0.95 +- 0.23%, respectively). These values contrast with those of the controls, in whom a significant increase in COHbc was associated with hyperbilirubinaemia (0.74 +- 0. 15% vs 0.60 +- 0.16%, respectively; p<0.05). tHb values were similar in both groups. CONCLUSIONS: Down's syndrome neonates had a greater risk of hyperbilirubinaemia, and higher COHbc values, than controls. However, excessive bilirubin production could not be exclusively responsible for the hyperbilirubinaemia. By inference, decreased bilirubin elimination probably plays a greater part in its pathogenesis than in controls. Down's syndrome neonates may have abnormal erythropoiesis, leading to increased haem turnover.  (+info)

Validation of the end-expired method for measuring carboxyhaemoglobin levels for the use in occupational and environmental exposure studies. (5/461)

Carbon monoxide is one of the most common toxins encountered in work settings, the gas being emitted in situations where there is incomplete combustion of carbon-containing substances. Its acute and chronic health effects have been well-documented. While identification of dangerous situations and evaluation of control measures are conducted by environmental monitoring, the body burden due to inhalation of carbon monoxide is measured by an individual's blood carboxyhaemoglobin level. Carboxyhaemoglobin level can be measured directly from a blood sample or, indirectly, by measuring the end-expired carbon monoxide level and using the charts provided to read the corresponding carboxyhaemoglobin level. As the end-expired method is not an intervention method, and is therefore easy to conduct, it is being used widely in epidemiological studies and it could also be used for individual measurements. This study presents a better statistical method for validating the end-expired method than the correlation method used and described in previous studies.  (+info)

Methylene chloride poisoning in a cabinet worker. (6/461)

More than a million workers are at risk for methylene chloride exposure. Aerosol sprays and paint stripping may also cause significant nonoccupational exposures. After methylene chloride inhalation, significant amounts of carbon monoxide are formed in vivo as a metabolic by-product. Poisoning predominantly affects the central nervous system and results from both carboxyhemoglobin formation and direct solvent-related narcosis. In this report, we describe a case of methylene chloride intoxication probably complicated by exogenous carbon monoxide exposure. The worker's presentation of intermittent headaches was consistent with both methylene chloride intoxication and carbon monoxide poisoning. The exposures and symptoms were corroborated by elevated carboxyhemoglobin saturations and a workplace inspection that documented significant exposures to both methylene chloride and carbon monoxide. When both carbon monoxide and methylene chloride are inhaled, additional carboxyhemoglobin formation is expected. Preventive efforts should include education, air monitoring, and periodic carboxyhemoglobin determinations. Methylene chloride should never be used in enclosed or poorly ventilated areas because of the well-documented dangers of loss of consciousness and death.  (+info)

Effects of exposure to low concentrations of carbon monoxide on exercise performance and myocardial perfusion in young healthy men. (7/461)

OBJECTIVE: To assess the effects of exposure to low concentrations of carbon monoxide (CO), as commonly measured in atmospheric urban air pollution and certain occupational environments, on exercise performance and myocardial perfusion in young healthy men, and the possible need for tighter restrictions on ambient concentrations of CO. METHODS: 15 young, healthy non-smoking men, 18-35 years old, were exposed blindly and randomly to air or to a mixture of CO and air, followed by an exercise treadmill test with thallium heart scintigraphy. Blood was drawn for determination of carboxyhaemoglobin before and at the end of the exposure, and for lactic and pyruvic acid at the beginning and the end of the exercise test. The main outcome measures include the duration of the exercise test, the maximal effort expressed in metabolic equivalent units (METs), the mean plasma lactic to pyruvic acid ratio at the end of the ergometry, ECG changes in the exercise test, and perfusion deficits in thallium heart scintigraphy. RESULTS: At the end of exposure to CO, the mean (SD) blood carboxyhaemoglobin concentration rose from 0.59% (0.08%) to 5.12% (0.65%) (p < 0.0001). At the end of the exercise period, the mean (SD) plasma lactate/pyruvate ratio, which reflects the level of anaerobic metabolism (69.9 (5.9) after air and 75.9 (7.0) after CO), was not significantly different between the two experimental groups. Exercise induced electrocardiographic changes were noted in only one subject after exposure to CO. No arrhythmias were detected in any of the subjects. Significant differences were found in the mean duration of the exercise test (p = 0.0012) and the METs (p = 0.0001). The mean adjusted difference of exercise duration between exposure to air and CO was 1.52 minutes 95% confidence interval (95% CI) 0.73 to 2.32 minutes. The mean adjusted difference of METs between exposure to air and CO was 2.04 95% CI 1.33 to 2.76. The models for duration of exercise and METs showed no significant sequence and period effects. Thallium myocardial perfusion imaging disclosed normal perfusion in all regions of the heart, with no significant differences in perfusion between the two exercise tests (after air or CO). CONCLUSION: Acute exposure to a low concentration of CO which produces blood carboxyhaemoglobin concentrations of 4%-6% significantly decreases exercise performance in young healthy men. No ischaemic electrocardiographic changes or disturbances in myocardial perfusion were found by graded exercise with thallium scintigraphy. Our findings suggest that pollution of atmospheric air by CO at concentrations which are commonly found in urban and industrial environments may exert an adverse effect on skeletal muscles, manifesting as decreased exercise performance.  (+info)

UV resonance raman spectra of ligand binding intermediates of sol-gel encapsulated hemoglobin. (8/461)

We report for the first time specific conformational changes for a homogeneous population of ligand-bound adult deoxy human hemoglobin A (HbA) generated by introducing CO into a sample of deoxy-HbA with the effector, inositol hexaphosphate, encapsulated in a porous sol-gel. The preparation of ligand-bound deoxy-HbA results from the speed of ligand diffusion relative to globin conformational dynamics within the sol-gel (1). The ultraviolet resonance Raman (UVRR) difference spectra obtained reveal that E helix motion is initiated upon ligand binding, as signaled by the appearance of an alpha14beta15 Trp W3 band difference at 1559 cm(-1). The subsequent appearance of Tyr (Y8a and Y9a) and W3 (1549 cm(-1)) UVRR difference bands suggest conformational shifts for the penultimate Tyralpha140 on the F helix, the "switch" region Tyralpha42, and the "hinge" region Trpbeta37. The UVRR results expose a sequence of conformational steps leading up to the ligation-induced T to R quaternary structure transition as opposed to a single, concerted switch. More generally, this report demonstrates that sol-gel encapsulation of proteins can be used to study a sequence of specific conformational events triggered by substrate binding because the traditional limitation of substrate diffusion times is overcome.  (+info)

*Carboxyhemoglobin

... or carboxyhaemoglobin (symbol COHb or HbCO) is a stable complex of carbon monoxide and hemoglobin (Hb) that ... This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ... Carboxyhemoglobin at the US National Library of Medicine Medical Subject Headings (MeSH). ... Gregory B. Vásquez; Xinhua Ji; Clara Fronticelli; Gary L. Gilliland (1998). "Human Carboxyhemoglobin at 2.2 Å Resolution: ...

*CO-oximeter

More recently, some 'pulse' or more precisely 'peripheral' oximeters have made it possible to estimate carboxyhemoglobin with ... carboxyhemoglobin and methemoglobin. Crit Care International, April-May, 8-9, 1995. Moran RF, The case for standardized ... as well as the dyshemoglobins such as carboxyhemoglobin (COHb) and methemoglobin (MetHb). The use of 'CO' rather than 'Co' or ' ... "Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood". Clinical Chemistry. 25 (8): 1388-93. PMID ...

*Workplace respirator testing

Carboxyhemoglobin formed due to inhalation of carbon monoxide. The biomonitoring results shown: (1) the intermittently usage of ... Evaluation of the effectiveness of the respirator was conducted by determining the content of carboxyhemoglobin in the blood ...

*Iron

Hemoglobin bound to carbon monoxide is known as carboxyhemoglobin. This effect also plays a minor role in the toxicity of ... PMC 395301 . Gregory B. Vásquez; Xinhua Ji; Clara Fronticelli; Gary L. Gilliland (1998). "Human Carboxyhemoglobin at 2.2 Å ...

*Breath carbon monoxide

This is known as "Fetal carboxyhaemoglobin" (%FCOHb). This level has also been found to be on average 1.8 times higher in the ... Maisel, William; Roger J. Lewis (2010). "apple Measurement of Carboxyhemoglobin: How Accurate is Accurate Enough?". Annals of ... carbon monoxide level has been shown to have a close relationship with the level of CO in the blood known as carboxyhaemoglobin ...

*Carbon monoxide

Additionally, a noninvasive carboxyhemoglobin (SpCO) test method from Pulse CO-Oximetry exists and has been validated compared ... Concentrations as low as 667 ppm may cause up to 50% of the body's hemoglobin to convert to carboxyhemoglobin. A level of 50% ... This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ... This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ...

*DLCO

Expected DLCO is also affected by the amount of hemoglobin, carboxyhemoglobin, age and sex. The correction for hemoglobin is ... Online resources exist to facilitate these corrections for altitude, hemoglobin, and carboxyhemoglobin. Generally DLCO is ...

*Oxygen-hemoglobin dissociation curve

The reaction HbO2 + CO → HbCO + O2 irreversibly displaces the oxygen molecules forming carboxyhemoglobin; the binding of the ... a person can suffer from severe tissue hypoxia while maintaining a normal pO2 because carboxyhaemoglobin does not carry oxygen ...

*Myoglobin

Hemoglobin can take the forms of oxyhemoglobin (HbO2), carboxyhemoglobin (HbCO), and methemoglobin (met-Hb); similarly, ...

*Hypoxia (medical)

Wald, NJ; Idle, M; Boreham, J; Bailey, A (May 1981). "Carbon monoxide in breath in relation to smoking and carboxyhaemoglobin ...

*Smoke inhalation

Weaver LK, Howe S, Hopkins R, Chan KJ (2000). "Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with ...

*Exhaust gas

It combines with hemoglobin to produce carboxyhemoglobin, which is ineffective for delivering oxygen to bodily tissues. In 2011 ...

*Blood

... in carbon monoxide poisoning is bright red, because carbon monoxide causes the formation of carboxyhemoglobin. In cyanide ... because carbon monoxide irreversibly binds to hemoglobin to form carboxyhemoglobin, so that less hemoglobin is free to bind ...

*HVAC

Carbon monoxide binds with hemoglobin in the blood, forming carboxyhemoglobin, reducing the blood's ability to transport oxygen ...

*Arterial blood gas test

... carboxyhemoglobin, and methemoglobin. ABG testing is mainly used in pulmonology and critical-care medicine to determine gas ...

*Grinker myelinopathy

... while the standard oxygen treatment normalizes carboxyhemoglobin levels. Another preventative measure one can take is to be on ...

*Dupont Plaza Hotel arson

"Analysis Of Carboxyhemoglobin And Cyanide In Blood From Victims Of The Dupont Plaza Hotel Fire In Puerto Rico" (PDF). Fire.nist ...

*Metal carbonyl

Vásquez, G. B.; Ji, X.; Fronticelli, C.; Gilliland, G. L. (1998). "Human Carboxyhemoglobin at 2.2 Å Resolution: Structure and ... in part because of their ability to carbonylate hemoglobin to give carboxyhemoglobin, which prevents the binding of O2. The ...

*Bohr effect

At the same time, CO is structurally similar enough to O2 to cause carboxyhaemoglobin to favor the R state, raising the oxygen ... This molecule serves as a competitive inhibitor for oxygen, and binds to haemoglobin to form carboxyhaemoglobin. haemoglobin's ... This increase is ultimately due to differences in interactions between heme groups in carboxyhaemoglobin relative to oxygenated ... this toxicity is reduced slightly by an increase in the strength of the Bohr effect in the presence of carboxyhaemoglobin. ...

*Tobacco smoking

Turner, JA; Sillett, RW; McNicol, MW (1977). "Effect of cigar smoking on carboxyhemoglobin and plasma nicotine concentrations ...

*Gaseous signaling molecules

This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ...

*S7 Airlines Flight 778

One flight attendant was found with a total of 85% of carboxyhemoglobin concentration inside her blood, along with her ...

*Biological functions of carbon monoxide

This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ...

*Ernest Beutler

... carboxyhemoglobin levels, and fetal hemoglobin levels. The latter approach depended on administration of estrogen, progesterone ...

*Boston (band)

... his death was the result of suicide by carbon monoxide poisoning as evidenced by carboxyhemoglobin. Delp's last concert with ...
Introduction: The inhalation of tobacco smoke can substantially raise the level of carboxyhemoglobin in the blood. Determination of the level of carboxyhemoglobin and methemoglobin can identify patients with increased risk for development of postoperative pulmonary complications. Material and Methods: Thirty patients scheduled for elective urologic surgery under general endotracheal anesthesia were allocated in two groups (n = 15 each). The study group comprised patients who were smoking cigarettes or tobacco pipe, while the control group included non-smokers. In both groups carboxyhemoglobin and methemoglobin levels were determined preoperatively, after preoxygenation, and one hour after completing the anesthesia. Postoperative pulmonary complications were assessed and recorded during the period of hospitalization.Results: The average values of carboxyhemoglobin between the two groups were statistically significantly different. Postoperative carboxyhemoglobin was higher in smokers compared to
TY - JOUR. T1 - Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting. AU - Kurt, T. L.. AU - Anderson, R. J.. AU - Reed, G.. PY - 1990. Y1 - 1990. N2 - Breath measurement of carbon monoxide (CO) can be rapidly performed in the emergency department setting by a reliable method that closely approximates carboxyhemoglobin. This method is helpful in the immediate determination of CO exposure for individual patients, but could serve as a valuable triage aid when large groups of patients are suspected of CO exposure. Serial CO determinations can be obtained during oxygen treatment to monitor for improvements without painful needle punctures and needless consumption of professional time and expense.. AB - Breath measurement of carbon monoxide (CO) can be rapidly performed in the emergency department setting by a reliable method that closely approximates carboxyhemoglobin. This method is helpful in the immediate determination of CO exposure for individual patients, but could ...
Carbon monoxide (CO) is produced by the incomplete combustion of carbon-containing material, notably tobacco, biomass fuel and fossil fuel. The carboxyhaemoglobin (COHb) level in the blood (half-life 2 -6 hours) after inhalation of CO will depend on concentrations of inspired CO, duration of exposure, pulmonary ventilation and the COHb level before the inhalation.4 COHb is a sensitive specific physiological marker of atmospheric CO exposure from both indoor and outdoor sources.. In water-pipe smokers expired CO was reported to increase by 300% after an hour of smoking, while in cigarette smokers it only increased by 60%.5 During a single water-pipe smoking session a smoker may produce a 24-hour urinary cotinine level that is equivalent to smoking 10 cigarettes a day (95% confidence interval (CI) 7 -13 cigarettes a day).6 Contrary to popular belief, noxious substances such as nicotine, tar and heavy metals (chromium, arsenic, lead) are found in the smoke of water-pipes.7 Although water-pipe ...
Clinically severe jaundice due to ABO incompatibility can occur when infants with blood type A or B are born to mothers with type O blood. An estimated 20 percent of pregnancies are ABO incompatible, but only a very small proportion of blood type A or B babies born to O type mothers develop overt ABO hemolytic disease. Despite the relative rarity of ABO hemolytic disease, it is common practice among pediatricians and family practice physicians to perform routine blood typing and antibody screening on all newborns born to type O mothers.. A very accurate and reliable laboratory measure of red blood cell destruction is the plasma carboxyhemoglobin level (COHb). COHb levels can be determined using a minute amount of blood, obtained at the same time the newborns heel is pierced to obtain blood for the mandatory newborn screen (performed on all newborns prior to discharge) in order to avoid an additional invasive procedure.. Our hope is to determine whether routine blood typing and anti-globulin ...
The concentration of carbon monoxide in the air of 67 iron, steel, or copper alloy foundries using sand molding was measured. About 1,100 carbon monoxide determinations were made. High concentrations of carbon monoxide were found in the area around the cupolas and the casting sites in iron foundries. The blood carboxyhemoglobin levels of 145 workers from iron foundries were measured. The carboxyhemoglobin level of 6% was exceeded in 26% of the nonsmokers and in 71% of the smokers.. ...
The effects of carbon monoxide on exercise tolerance as assessed by the distance walked in 12 minutes were studied in 15 patients with severe chronic bronchitis and emphysema (mean forced expiratory volume in one second 0.56 1, mean forced vital capacity 1.54 1). Each subject walked breathing air and oxygen before and after exposure to sufficient carbon monoxide to raise their venous carboxyhaemoglobin concentration by 9%. There was a significant reduction in the walking distance when the patients breathed air after exposure to carbon monoxide (p less than 0.01), and the significant increase in walking distance seen after exercise when breathing oxygen at 2 1/minute via nasal cannulae was abolished if carbon monoxide has previously been administered. Thus concentrations of carboxyhaemoglobin frequently found in bronchitic patients who smoke may reduce their tolerance of everyday exercise, possibly by interfering with the transport of oxygen to exercising muscles. ...
Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood.: This paper describes separate spectrophotometric procedures for rapidly measuri
Carbon monoxide poisoning is the most common type of fatal air poisoning in many countries.[28] Carbon monoxide is colorless, odorless, and tasteless, but highly toxic. It combines with hemoglobin to produce carboxyhemoglobin, which usurps the space in hemoglobin that normally carries oxygen, but is ineffective for delivering oxygen to bodily tissues. Concentrations as low as 667 ppm may cause up to 50% of the bodys hemoglobin to convert to carboxyhemoglobin.[29] A level of 50% carboxyhemoglobin may result in seizure, coma, and fatality. In the United States, the OSHA limits long-term workplace exposure levels above 50 ppm.[30]. The most common symptoms of carbon monoxide poisoning may resemble other types of poisonings and infections, including symptoms such as headache, nausea, vomiting, dizziness, fatigue, and a feeling of weakness. Affected families often believe they are victims of food poisoning. Infants may be irritable and feed poorly. Neurological signs include confusion, ...
Carbon monoxide is produced from the partial oxidation of carbon-containing compounds; it forms when there is not enough oxygen to produce carbon dioxide (CO2), such as when operating a stove or an internal combustion engine in an enclosed space. In the presence of oxygen, including atmospheric concentrations, carbon monoxide burns with a blue flame, producing carbon dioxide.[11] Coal gas, which was widely used before the 1960s for domestic lighting, cooking, and heating, had carbon monoxide as a significant fuel constituent. Some processes in modern technology, such as iron smelting, still produce carbon monoxide as a byproduct.[12] A large quantity of CO byproduct is formed during the oxidative processes for the production of chemicals. For this reason, the process off-gases have to be purified. On the other hand, considerable research efforts are made in order to optimize the process conditions,[13] develop catalyst with improved selectivity [14] and to understand the reaction pathways ...
Issue: Desiccated (or dry) CO2 absorbers such as soda lime and Baralyme can degrade inhaled anesthetics to carbon monoxide, and my produce carboxyhemoglobin concentrations in excess of 30%.. Mechanism: These CO2 absorbers contain strong bases (sodium hydroxide and potassium hydroxide) that can extract labile protons from anesthetic molecules, resulting in the production of CO. (There are new CO2 absorbers that do not contain KOH or NaOH, such as Amsorb. These do not react with inhaled agents to produce CO, but they are fairly expensive).. Incidence: The incidence of CO exposure is 0.46% for the first case of the day (2.9% in non-OR settings) and overall incidence is 0.26%.. Factors that increase the production of CO and carboxyhemoglobin:. 1. Inhaled anesthetic used: des,/=enflurane,iso,,halothane=sevo. 2. Absorbent dryness. 3. Type of absorbent (Baralyme,soda lime). 4. Increased temperature. 5. Low fresh gas flow. 6. Increasing anesthetic concentration. 7. Size of patient compared to amount of ...
A method is described for determining the diffusion coefficient of solutes by determining the rate of passage of the solute through a thin porous membrane between two solutions of different concentration.. The method has been used to determine the diffusion coefficient of carbon monoxide hemoglobin. This was found to be 0.0420 ± 0.0005 cm.2 per day at 5°C.. The molecular weight of carbon monoxide hemoglobin calculated by means of Einsteins equation from this quantity is 68,600 ± 1,000.. ...
Description: Carboxyhemoglobin, a complex of hemoglobin and carbon monoxide, is a marker of exposure to inhaled carbon monoxide (CO). CO gas is produced from almost any fire as the result of incomplete combustion to CO2, and the normal individual will have about 1 or 2 % of their hemoglobin in the form of carboxyhemoglobin, and up to 5% depending on environmental circumstances. Smokers can have levels as high as 10% or even higher. Poisoning with CO generally results from improperly vented furnaces, automobile exhaust, and fires, with carboxyhemoglobin:hemoglobin ratios of 10-30% found in symptomatic individuals and 30-90% in fatalities. With a 230 fold greater affinity, inhaled CO avidly replaces oxygen at its hemoglobin binding site. In addition, replacing even one of the 4 sites of the hemoglobin tetramer with CO prevents dissociation of the remaining 3 oxygen moieties to tissue (known as left shift of O2 dissociation curve). As a result, hemoglobin remains red and skin color is rosy despite ...
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article{adc8b173-8290-4fe1-95e9-3dbfeae73d48, abstract = {Background- The extent to which differences in cardiovascular risk between smokers with similar daily tobacco consumption may be related to plasma levels of inflammation-sensitive proteins (ISP) and whether these proteins are associated with levels of carboxyhemoglobin (COHb%) have not been clarified.,br/,,br, ,br/,,br, Methods and Results- In a population-based cohort of 1489 never smokers, 1685 former smokers, and 2901 current smokers, aged 28 to 61 years, plasma levels of orosomucoid ({alpha}1-acid glycoprotein), {alpha}1-antitrypsin, haptoglobin, fibrinogen, and ceruloplasmin were measured. COHb% levels were available for 2098 of them. Incidence of myocardial infarction, stroke, and death were monitored over 18.7±4.7 years. The proportion with high ISP levels (ie, >=2 ISP in the top quartile) increased progressively with daily tobacco consumption (P<0.01) and COHb% (P<0.01). In all smoking categories, the incidence of ...
Carbon monoxide [‎CO]‎ poisoning from coal and gas heaters is a public health concern in Turkey. This study estimated the prevalence, mortality rate and clinical predictors of severity of CO poisoning cases treated at the emergency unit of the Uludag University Medical School, Bursa from 1996 to 2006. Of 305 patients treated over a 10-year period, only 1 case was recorded as suicide. The CO source was a coal heater in 85.9% of cases. Mean Glasgow coma score [‎GCS]‎ on admission was 12.8 [‎SD 0.2]‎ and mean carboxyhaemoglobin level was 21.6% [‎SD 0.92%]‎. There were statistically significant associations between higher GCS score, older age and higher HbCO level. Better education of the public is vital for the prevention of these ...
Masimo (NASDAQ: MASI) is the global leader in innovative noninvasive monitoring technologies. Our mission is to improve patient outcomes and reduce the cost of care by taking noninvasive monitoring to new sites and applications. In 1995, the company debuted Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, which has been shown in multiple studies to significantly reduce false alarms and accurately monitor for true alarms. The benefits of Masimo SET® have been proven in more than 100 independent and objective studies and it is estimated to be used on more than 100 million patients in leading hospitals and other healthcare settings around the world. In 2005, Masimo introduced rainbow® Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously could only be measured invasively, including total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), and Pleth Variability Index ...
1. We have compared rebreathing, breath-hold and mean alveolar methods of measuring alveolar carbon monoxide (CO), at levels similar to those found in smokers, as a preliminary to using them as indirect measures of carboxyhaemoglobin levels. In the present study alveolar CO levels were raised by rebreathing a 2% CO mixture.. 2. Breath-hold CO was measured after breath-hold times of 0-35 s in 5 s increments. Using generalized linear models, the maximum value for breath-hold CO was estimated to occur at 23 s. Breath-hold CO after a 20 and 25 s breath-hold were similar to and significantly greater than those of less than 20 s or greater than 25 s.. 3. As expired CO increased, the difference between breath-hold and mean alveolar CO became proportionally larger. On average, breath-hold CO was 24% larger than mean alveolar CO.. 4. Rebreathing, breath-hold and mean alveolar CO were compared at four different inspired oxygen concentrations. Expired CO increased significantly with increasing oxygen for ...
Environmental survey and medical evaluation data reveal potentially toxic exposures to carbon-monoxide by warehouse loading dock workers. Carbon-monoxide (630080) concentrations exceed the NIOSH standard of 35 parts per million, with levels in excess of 50 parts per million in winter months when doors remain closed. Industrial truck operators show a significant rise in blood carboxyhemoglobin, ass
Theron, Ansa et al. Carboxyhaemoglobin levels in water-pipe and cigarette smokers. SAMJ, S. Afr. med. j., Feb 2010, vol.100, no.2, p.122-124. ISSN 0256- ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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1A9W: Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of gower II (alpha2 epsilon2) haemoglobin at 2.9 A resolution.
Literature References: Hb; ferrohemoglobin. The major component of red blood cells which transports oxygen from the lungs to body tissues and facilitates the return transport of carbon dioxide. Mammalian hemoglobins have mol wts of about 64,500. Composed of four peptide chains called globins, each of which is bound to a heme, q.q.v. Normal human hemoglobin is composed of a pair of two identical chains. Iron is coordinated to four pyrrole nitrogens of protoporphyrin IX, and to an imidazole nitrogen of a histidine residue from the globin side of the porphyrin. The sixth coordination position is available for binding with oxygen and other small molecules. Called oxyhemoglobin, HbO2, in the oxygenated form and carboxyhemoglobin, HbCO, when oxygen is displaced by carbon monoxide. Binds reversibly with oxygen while the heme iron remains in the ferrous state. Autoxidation is prevented by the cover of hydrophobic groups of the globin. When the iron in hemoglobin is oxidized from the ferrous to the ...
Background: Cigarette smoking is a risk factor for several diseases including cardiovascular disease, chronic obstructive pulmonary disease and lung cancer, but the role of specific smoke constituents in these diseases has not been clearly established. Methods: The relationship between biomarkers of potential harm (BOPH), associated with inflammation [white blood cell (WBC), high sensitivity C-reactive protein (hs-CRP), fibrinogen, von Willebrand factor (vWF)], oxidative stress [8-epi-prostaglandin F2α (8-epiPGF2α)] and platelet activation -[11-dehydro-thromboxin B2 (11-dehTxB2)], and machine measured tar yields (grouped into 4 categories), biomarkers of exposure (BOE) to cigarette smoke, nicotine and five metabolites [(Nicotine equivalents) - NE)], 4-methylnitrosamino-1-(3-pyridyl)-1-butanol (total NNAL), carboxyhemoglobin (COHb), 1-hydroxypyrene (1-OHP), 3-hydroxypropylmercapturic acid (3-HPMA) and monohydroxybutenyl-mercapturic acid (MHBMA), was investigated in 3,585 adult smokers (AS) and ...
When I was searching for a science project, I realized that the question of how much carboxyhemoglobin is needed to suggest smoking seemed unanswered," said coauthor and son Ashray Reddy. "I thought that by trying to answer this question, I could help people quit smoking.". Researchers used the pulse cooximeter, a device that is clipped to the patients finger and reads the percentages of poisoned blood through a light that is shined through the nail bed. A total of 476 patients who visited the clinic participated. Patients were identified as a smoker, based on a combination of their questionnaire responses and if theyre CO levels exceeded 6% of their blood. Researchers were also able to identify secondhand smokers based on slight changes found in their levels, as well. Results showed that 98 patients were smokers, 72 were secondhand smokers, and 306 were nonsmokers.. "For the first time, the entire smoking cessation story can be quickly and noninvasively played out from beginning to ...
Masimo Rainbow SET technology uses multiple wavelengths of light to continuously and noninvasively measure hemoglobin, Oxygen Content, carboxyhemoglobin and methemoglobin, as well as providing the most reliable probe-off detection ...
... is a chapter in the book, Emergency Medicine, containing the following 1 pages: Carboxyhemoglobin.
... is a chapter in the book, Emergency Medicine, containing the following 1 pages: Carboxyhemoglobin.
... ,QC 253 is an assayed quality control material used for monitoring the measurements of total hemoglobin and hemoglobin fractions on CO-Oximeter instrumentation. It provides an alternative for those needing a control that parallels the human physiologic range for tHb, O2Hb, and COHb. QC 253 is availa,medicine,medical supply,medical supplies,medical product
CO-oximetry provides the means for automated spectrophotometric measurement of the concentration of total hemoglobin (ctHb) in blood and the percentages of the four...
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The Arecont Vision AV20365CO-HB helps you to keep an eye on work place and home round-o-clock. It also helps you to protect the privacy of people in the surveillance area by blocking multiple regions of a video in almost any arbitrary shape.
I also find drinks like an ice cold 7up as having the same clearing effect as James glass of ice water. Perhaps, the most effective measure of preventing sickness for someone just learning how to smoke a cigar is sugar-loading. Of course, this wont do if you have sugar-averse health conditions (like diabetes mellitus), but sugar is an antidote to nicotine overdose. In fact, if you try to oberve the old cigar smokers in the Caribbean, they carry cigar cubes with them and just pop one as soon as they start to feel a bit queasy from cigar smoking. You can ingest raw sugar when you feel like getting sick or, if youre not comfortable with the idea, just sweeten your espresso a notch higher or have a sugary drink while you smoke.. Over time, as you mature from a beginner learning how to smoke a cigar to a veteran cigar smoker, youll also observe that you have progressively developed a high level of tolerance to nicotine. This is gradual, however, so beginners are better off following Yees advice ...
Mini cigars are small cigars not much larger than a long cigarette. Top mini cigars are made from the same quality tobacco used to make full-sized cigars. The smaller cigars are perfect for cigar smokers who want to step outside for a smoke break during work but dont have the time to smoker a big cigar.
Jungbluth and colleagues (22) generated monoclonal antibody 806 [mAb806(IgG2b)] by immunizing mice with murine NR6 fibroblasts expressing human EGFRvIII but not wtEGFR. Characterization of mAb806 confirmed binding to EGFRvIII, but, unexpectedly, mAb806 also bound to tumor cells overexpressing wtEGFR at a level in excess of 1 × 106 receptors per cell (23-26). In vivo studies confirmed that mAb806 bound to and reproducibly inhibited xenograft tumors that expressed EGFRvIII or overexpressed wtEGFR (19, 27-30). Of interest, no mAb806 binding was detected in normal tissues such as the liver (22).. The mechanism of mAb806′s tumor specificity was elucidated with the discovery that the epitope is located between amino acids 287 and 302 in the CR1 domain of the EGFR ECD (31, 32). This epitope is masked in the inactive monomer state (Fig. 1A) or the fully liganded back-to-back dimer state (Fig. 1B), which explains the lack of mAb806 binding to normal tissues in which EGFR is quiescent. However, the ...
Low concentrations of endogenous carbon monoxide (CO), generated primarily through degradation of heme from hemeproteins, have been shown to maintain physiological function of organs and to exert cytoprotective effects. However, high concentrations of carboxyhemoglobin (COHb), formed by CO binding to hemoglobin, potentially prevent adequate O-2 delivery to tissues by lowering arterial O-2 content. Elevated heme-protein concentrations, as found in marine mammals, are likely associated with greater heme degradation, more endogenous CO production and, consequently, elevated COHb concentrations. Therefore, we measured COHb in elephant seals, a species with large blood volumes and elevated hemoglobin and myoglobin concentrations. The levels of COHb were positively related to the total hemoglobin concentration. The maximum COHb value was 10.4% of total hemoglobin concentration. The mean (+/- s.e.m.) value in adult seals was 8.7 +/- 0.3% (N=6), while juveniles and pups (with lower heme-protein ...
The surveys described in this report document excessive CO exposures in employees and excessive and fatal CO exposures in vacationers amid large numbers of boats. The surveys also document substantial CO exposures in the late afternoon during crowded boating conditions, mirrored by elevations in expired CO concentrations among employees and vacationers. The majority of LHC employees had estimated %COHb levels indicating the potential for adverse health effects. Vacationers tested had higher %COHb levels than employees. These results indicate that elevated %COHb levels can occur among persons in open, outdoor settings. Previously described outdoor boat-related poisonings involved dangers to occupants of individual boats (e.g., houseboats and ski-boats) (4,5). The findings in this report are subject to at least three limitations. First, evaluation of CO-related symptoms was limited by a lack of participant information on dehydration, heat stress, physical and mental stress, and vacationer alcohol ...
Carbon monoxide (CO) is generated wherever combustion occurs, including the operation of gasoline engines, as well as heating and cooking appliances. It is invisible, odorless, tasteless, and deadly. Faulty venting or even a wind shift can create a dangerous situation, particularly in confined areas like boat cabins. Typical symptoms of CO exposure can be mistaken for the flu or seasickness, making accurate on board CO detection a necessity.. The CO Alarm uses a microprocessor to measure and accumulate CO levels. Using the principle of "Time Weighted Averaging" (TWA), the CO Alarm monitors CO concentration, temperature, and time to calculate levels of Carboxyhemoglobin (COHb). COHb is the degree to which the oxygen carrying capacity of the blood is impeded by the union of carbon monoxide to the hemoglobin and is expressed as a percentage. In simpler terms, our bodies prefer absorbing CO to oxygen, and COHb is the ratio of absorbed carbon monoxide to oxygen in the bloodstream. The CO Alarm ...
There is no effective drug for the therapy of acute carbon monoxide (CO) poisoning. The purpose of the present study was to investigate the potential preventive and therapeutic effects of hemin on an animal model of acute CO poisoning and to provide a potential therapeutic candidate drug. A total of 80 Kunming mice were randomly divided into four groups, namely the air control, acute CO poisoning, hemin-treatment + CO and hemin-pretreatment + CO groups (n=20 each). Furthermore, the mortality rate of mice, blood carboxyhaemoglobin (HbCO) concentration and serum malondialdehyde (MDA) concentration were measured, and pathological changes of the hippocampal area were determined using histochemical staining ...
Home Energy, the magazine of the home performance industry since 1984, publishes residential energy efficiency, comfort, safety, and green building best practices for remodelers, builders and contractors.
Home Energy, the magazine of the home performance industry since 1984, publishes residential energy efficiency, comfort, safety, and green building best practices for remodelers, builders and contractors.
HBOT speeds the removal of CO from the body. In a study using volunteer subjects, the average time necessary to reduce blood CO levels by half, (written as T1/2, where T is time) was 320 minutes (range of 128 - 409 minutes).2 When exposed to HBOT at 3 atmospheres absolute (ATA), the T1/2 decreases to approximately 23 minutes.3 HBOT also inhibits the tissue destructive inflammatory processes instigated by CO, which can persist after CO levels drop to within normal limits. It is for this reason that measurement of CO blood concentration (abbreviated COHb - carboxyhemoglobin) alone is not the sole determinant of whether HBOT is used or a reliable measurement of poisoning severity. COHb will naturally decline with time, but tissue damage may persist after CO blood levels have declined to normal or expected levels. In cases of prolonged subacute exposure which can include warehouses, parking garages, auto shops etc.), COHb may never reach severe levels but may still produce signs of toxicity. ...
Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine residues. We mutated the distal histidine to glutamine (H64Q) and substituted three surface cysteines with less reactive amino acids to form a five-coordinate heme protein (Ngb-H64Q-CCC). This molecule exhibited an unusually high affinity for gaseous ligands, with a P50 (partial pressure of O2 at which hemoglobin is half-saturated) value for oxygen of 0.015 mmHg. Ngb-H64Q-CCC bound CO about 500 times more strongly than did hemoglobin. Incubation of Ngb-H64Q-CCC with 100% CO-saturated hemoglobin, either cell-free or encapsulated in human red blood cells, reduced the half-life of carboxyhemoglobin to 0.11 and 0.41 min, respectively, from ≥200 min when the ...
TABLE-US-00001 TABLE 1 BIOMARKERS OF HEALTH/INFLAMMATION (Serum/blood concentrations) Glucose 100 mg/dL ATP 1000 nanomol/L 507.18 ng/nanomol 507 ng/ml GSH (glutathione) 15-30 micromol/L MT metallothionein 1-10 ng/g in serum or urine EPINEPHRINE Supine: , or =111 pg/mL Standing: , or =141 pg/mL NOREPINEPHRINE Supine: 70-750 pg/mL Standing: 200-1,700 pg/mL ACTH 10-60 pg/mL CORTISOL 7-25 mcg/dL Arginine Vasopressin Adults: ,1.7 pg/mL Prolactin Males: 3-13 ng/mL Females: 3-27 ng/mL Cytokine panel 0-5 pg/ml TESTOSTERONE, TOTAL 75-400 ng/dL Progesterone Females, 0.20-27.00 ng/mL C-reactive protein ≧150 mcg/dl HEMATOLOGY Activated Partial Thromboplastin ≧150 sec (biomarker) Time, Plasma Fibrinogen ≦60 - mg/dL Hemoglobin ,7 weeks ≦6.0 ≧ 20.0 g/dL INR (International Normalizing Ratio) - .sup. ≧5.0 (biomarker) CHEMISTRY Ammonia ,1 year - ≧500 mcg/dL Calcium, Total ≦6.5 ≧ 13.0 mg/dL Calcium, Ionized, Blood ≦3.0 ≧ 6.5 mg/dL Carbon Monoxide (Carboxyhemoglobin ≧20% Level) - Creatinine, ...
Medical examiners concluded that the noxious gas accidentally caused the deaths of Roger Hanna Morash, 35, and Valerie Morash, 32, after finding high levels of carboxyhemoglobin in their blood. When Roger Hanna Morashs co-worker came to the two-story apartment on the afternoon of Jan. 23 - he worked from home as a video game developer - she unlocked the apartment door to find him and a cat motionless on the floor upstairs. First responders found another cat and the body of Valerie Morash in the second-floor bedroom. All the usual suspects - heaters, stovetops, the cars in the driveway - were devoid of dangerous levels of carbon monoxide, later inspections revealed. A laser cutter and 3-D printer, which were in the office next to the couples bedroom, were dismissed as likely sources because the printer wasnt powered on and the laser cutter was plugged in to a power strip that was switched off, Bracamontes said. Dr. Paul Blanc, a professor of medicine at UCSF who specializes in occupational and
In patients with chronic stable angina, smoking a single marijuana cigarette decreased exercise time to angina by 48%. It is postulated that that marijuana-induced sympathetic stimulation increases myocardial oxygen demand. This, along with a decreased oxygen supply due to carboxyhemoglobin formation from inhalation of products of combustion in the marijuana cigarette, decreases the exercise capacity.19. To determine the role of marijuana as a trigger for acute coronary syndrome (ACS), Mittelman et al. performed a case-crossover analysis on 3,882 patients from Onset (Determinants of Myocardial Infarction Onset Study). Among 3,882 patients, 124 reported marijuana use in the past year. The authors found an elevated risk up to 4.8 times for MI within 1 hour of use of marijuana. The risk declined rapidly after 1 hour. It should be noted that the number of patients who reported marijuana use constituted only 3.2% of the entire group. A calculated annual risk of 1.5-3% of acute cardiovascular event ...
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Vítek, Libor; Gbelcová, Helena; Muchová, Lucie; Váňová, Kateřina; Zelenka, Jaroslav; Koníčková, Renata; Šuk, Jakub; Zadinova, Marie; Knejzlík, Zdeněk; Ahmad, Shakil; Fujisawa, Takeshi; Ahmed, Asif and Ruml, Tomáš (2014). Antiproliferative effects of carbon monoxide on pancreatic cancer. Digestive and liver disease, 46 (4), pp. 369-375. Vítek, Libor; Gbelcová, Helena; Muchová, Lucie; Váňová, Kateřina; Zelenka, Jaroslav; Koníčková, Renata; Šuk, Jakub; Zadinova, Marie; Knejzlík, Zdeněk; Ahmad, Shakil; Fujisawa, Takeshi; Ahmed, Asif and Ruml, Tomáš (2014). Antiproliferative effects of carbon monoxide on pancreatic cancer. Digestive and Liver Disease, 46 (4), pp. 369-375. Nayeri, Unzila A.; Buhimschi, Irina A.; Laky, Christine A.; Cross, Sarah N.; Duzyj, Christina M.; Ramma, Wenda; Sibai, Baha M.; Funai, Edmund F.; Ahmed, Asif and Buhimschi, Catalin S. (2014). Antenatal corticosteroids impact the inflammatory rather than the antiangiogenic profile of women with ...
Masimo (NASDAQ:MASI) announced today, in conjunction with its CE marking, the limited market release of the Spot-Check Rad-67™ Handheld Pulse CO-Oximeter®. Rad-67 offers Measure-through Motion and Low Perfusion™ SET® pulse oximetry and upgradeable rainbow® noninvasive monitoring technology in a compact, portable spot-check device. With the universal reusable rainbow® DCI®-mini sensor, Rad-67 features Next Generation SpHb® (noninvasive total hemoglobin) technology. This Smart News Release features multimedia. View the full release here: http://www.businesswire.com/news/home/20170605005349/en/ Masimo Rad-67™ Handheld Pulse CO-Oximeter® with rainbow® DCI®-mini Sensor (Photo: Business Wire) Next Generation SpHb technology offers improved motion tolerance and a faster time to display SpHb results (in as few as 30 seconds). In addition, field performanc
A stable reference solution for calibrating and monitoring blood gas instrumentation is disclosed. The solution comprises an aqueous mixture containing a hemoglobin solution derived from a mammalian source which comprises at least about 95% reduced hemoglobin. The solution additionally contains a bicarbonate buffer and a metal catalyzed methemoglobin reducing system and an organic buffer. To provide a control element having a variety of properties similar to fresh, whole, human blood, the reference solution is stored in a sealed ampule under an inert atmosphere containing CO2 until just prior to use. The ampule is subsequently opened and the solution is equilibrated with a gas mixture having components which provide gasses in a physiological range to the solution. The solution is characterized by exhibiting properties similar to fresh blood subsequent to equilibration and an extended storage life prior to equilibration.
James Gandolfini, the larger-than-life Emmy award-winning actor who played mob boss Tony Soprano, has met his end in Rome, due to an apparent heart attack. At age 51, his passing was entirely premature. As Tony Soprano, Gandolfini insinuated himself into popular culture as the big, menacing, complex and implacable mobster who ruled his criminal empire with old-school, strong-arm tactics. But every tough guy knows that theres someone - or something - tougher out there. For Tony Soprano, the hit man was likely heart disease.. The much-beloved Gandolfini was by all accounts a marvelous friend and deeply respected by his peers. He had a charismatic personality and a great sense of humor. He was also very overweight, a cigar smoker and a man known to remain at the dinner table until the last strands of pasta and crumbs of tiramisu had been taken care of. As Tony Soprano, he could menace just about anybody. But as actor Gandolfini, his lifestyle vulnerabilities made him an easy target for a highly ...
Ann Arbor, MI, April 8, 2014 /3BL Media/ - While preventable, carbon monoxide poisoning is a serious and sometimes fatal condition. Large weather events, such as snowstorms and heavy storms that cause power outages, can lead to an increase in the number of reported carbon monoxide exposures. Researchers from Hartford Hospital in Hartford, Connecticut explored the link between these major storms and the rise in carbon monoxide exposure cases. They found that portable generators were the most common source of carbon monoxide exposure after storms which resulted in power losses; car exhaust was the most frequent source of exposure after heavy snowstorms. Their findings are published in the May issue of the American Journal of Preventive Medicine.. In 2011, 12,136 unintentional exposures were reported to U.S. Poison Control Centers. Carbon monoxide is an odorless, colorless, and tasteless gas that can build up to dangerous levels in unventilated areas. Symptoms of carbon monoxide poisoning include ...
Carbon monoxide can be a silent killer.People who are exposed to excessive carbon monoxide often initially exhibit such nonspecific symptoms as headache, fatigue, dizziness, nausea and vomiting that can be confused with the flu or other illnesses, said Dr. Amber Bradford, an emergency medicine physician with Akron General Medical Center.Carbon monoxide is a colorless, odorless, tasteless gas, making exposure difficult to detect.
The Ninth Circuit is set to decide whether carbon monoxide falls within the absolute pollution exclusion of a general liability insurance policy. At issue in Colony Insurance Company v. Victory Construction LLC, et al., No. 17-35357 is a ruling by an Oregon federal district court that a policy issued by Colony Insurance Company to Victory Construction LLC does not provide coverage for injury claims involving indoor carbon monoxide poisoning from a negligently installed pool heater.. The exclusion provides that the Colony policy does not apply to "[b]odily injury. . . which would not have occurred in whole or part but for the actual, alleged or threatened discharge, dispersal, seepage, migration, release or escape of hazardous materials at any time." The policy defines "hazardous materials" to include "pollutants" which was further defined to include any "gaseous or thermal irritant or contaminant." As a matter of first impression under Oregon law, the district court concluded that the plain ...
One adult and one child were taken to hospitals after exposure to a high level of carbon monoxide at a home in Northwest Washington, offi...
Fire officials say crews went to the Hickory Hollow Cooperative apartment complex Friday evening after getting a report of two unconscious people.
To study the role of endogenous carbon monoxide (CO) in collagen metabolism during hypoxic pulmonary vascular remodeling, a total of 18 Wistar rats were used in the study and they were randomly divided into three groups: hypoxia group (n=6), hypoxia with zinc protoporphyrin-IX (ZnPP-IX) group (n=6) and control group (n=6). The measurement of mean pulmonary artery pressure (mPAP) and carboxyhemoglobin (HbCO) formation in lung tissue homogenates was measured. A morphometric analysis of pulmonary vessels was performed, in which the percentage of muscularized arteries (MA); partially muscularized arteries (PMA) and nonmuscularized arteries (NMV) in small and median pulmonary vessels, relative medial thickness (RMT) and relative medial area (RMA) of pulmonary arteries were analyzed. Collagen type I and III and transforming growth factor-beta(3) (TGF-beta(3)) expressions were detected by immunohistochemical assay. The expressions of procollagen type I and III and TGF-beta(3) mRNA were detected by in ...
The patient had carbon monoxide poisoning, which caused respiratory insufficiency, neurologic changes (loss of consciousness and visual impairment) and cardiac dysfunction (elevated troponin I, creatine kinase-MB fraction and carboxyhaemoglobin levels, and left ventricular dysfunction). Visual field defect is a significant outcome of occipital lobe infarct,(4) and the diffusion restriction observed in the left occipital lobe of our patient is evidence that the vision loss resulted from an occipital lobe ischaemic infarct.. Carbon monoxide inhibits the mitochondrial electron transport system and activates polymorphonuclear leucocytes that cause brain lipid peroxidation. This process may explain the delayed outcomes of carbon monoxide intoxication such as late encephalopathy.(5) Acute brain injury in patients exposed to carbon monoxide is usually caused by hypoxia. Neurons normally require major amounts of oxygen and glucose, and they are the cells in the central nervous system that are most ...
DUNMORE - At least one person remained hospitalized Sunday night and a Dunmore hotel is closed today after more than 200 guests were evacuated Sunday morning. More than two dozen were taken to area hospitals to be evaluated for possible carbon monoxide inhalation.. Those staying at the Best Western Plus Hotel on Tigue Street with symptoms were removed in buses and ambulances after a carbon monoxide leak "stemming from a furnace" was discovered just before 9 a.m., Dunmore Fire Chief Christopher DeNaples said.. Twenty-four people were taken to Geisinger Community Medical Center. By 5 p.m. all but one had been released, according to hospital spokeswoman Westyn Hinchey. The last patient was transferred to the Hospital of the University of Pennsylvania for treatment of carbon monoxide exposure, Ms. Hinchey said. She said she could not release that persons name and did not know his/her condition.. Another five guests went to Regional Hospital in Scranton, Commonwealth Health spokeswoman Renita ...
Lt. Robert Deitch said the husband was found dead in the home. His wife was found unconscious in the home and was transported to Overlook Medical Center in Summit.. Deitch said the incident seems to involve exposure to carbon monoxide fumes, and police are awaiting autopsy results. Deitch said the incident is not a criminal matter.. According to a police monitoring service, officers were sent to a home at 12 Cottage Court around 1:20 p.m. Wednesday for a report of a major gas leak. The police monitoring service later indicated that an elderly couple had left their vehicle running in the garage overnight and were exposed to carbon monoxide.. Carbon monoxide is a colorless, odorless, tasteless gas.. The Chicago Tribune reported a couple in their 70s this week were found dead in their home, apparently poisoned by carbon monoxide from a car with a keyless ignition that was accidentally left running in the garage.. In April, four elderly Queens residents died from carbon monoxide exposure after a car ...
When we breathe it, carbon monoxide combines with with the red blood cells in the blood and displaces the oxygen our bodies need to survive. Carbon monoxide combines with the red blood cells over 200 times more easily than oxygen and creates a condition known as carboxyhemoglobin saturation. Carbon monoxide, instead of oxygen, then enters the vital organs through the bloodstream. Our organ tissues require oxygen; without it, our organs start to asphyxiate or suffocate. It takes the body much longer to eliminate carbon monoxide, however its absorption is very fast. ...
Healthy pigs were premedicated with intramuscular ketamine (20 mg/kg body weight [BW]) and midazolam (0.5 mg/kg BW). The animals were endotracheally intubated, and anesthesia was maintained with intravenous infusion of fentanyl (10 μg · kg BW−1· h−1) and propofol (4-6 mg · kg BW−1· h−1), and muscle relaxation was performed with cisatracurium (0.7-1 mg · kg BW−1· h−1). Basal saline volume administration was infused with 350 ml/h. The lungs were ventilated with a frequency of 14/min, a tidal volume of 8-10 ml/kg BW, and a positive end-expiratory pressure of 5 mbar. Inspired oxygen fraction was constantly 0.5. To monitor blood pressures as well as blood gas analysis, an arterial catheter was inserted in the right carotid artery. In addition, a pulmonary thermodilution catheter (7 French; Arrow, Reading, PA) was inserted into the pulmonary artery via an 8.5-French sheet (Arrow) in the right internal jugular vein. All animals received sternotomy after complete hemodynamic ...
Every year, more than 40,000 Americans are bought to the emergency room because of carbon monoxide poisoning. Carbon Monoxide forms as a result of incomplete combustion of fuel, in the absence of oxygen. When fuel burns in an enclosed space, such as oil, wood and gasoline, eventually the oxygen in the room is exhausted and the end product of combustion is carbon monoxide.. Acute exposure to carbon monoxide can have severe repercussions, both physical and neurological, and even death by asphyxiation.. Our blood carries oxygen from the lungs to every cell in the body by the help of hemoglobin. Our cells thrive on oxygen and produce energy by respiration, especially the brain cells. When we inhale carbon monoxide, it reacts with hemoglobin in the blood to form carboxyhemoglobin and displaces oxygen absorbed in the hemoglobin.. This impairs the ability of the blood as a mode of transportation of oxygen. Within seconds of not receiving oxygen, brain cells begin to die, triggering a cascading effect ...
The owner of a Metro Vancouver farm where 42 workers were taken to hospital for possible carbon monoxide exposure says they have been discharged and are safe.
I have over 25 years experience in the field of Chemical and Materials Safety. My experience includes incident investigations and assessments for industrial, commercial, and domestic applications. I am highly knowledgeable in chemical material analysis; air emissions; chemical and material forensics; petrochemical characterization; unknown material identification; failure analysis plastic metal; incident root cause; chemical material interactions; mechanical testing materials; failure modes and effects analysis (FMEA); soil, water, gas, testing, and analysis; chemical handling; chemical safety and exposure; EPA, OSHA, and federal standards. My additional experience consists of automobile fuel tank skid plate material, plastic bilge pump failure investigation, street paint pressure vessels, tiki torch burn injuries, carbon monoxide exposure, and industrial metal plating substances. My applications and experience includes plastics, metal alloys, composites, fuels, lubricants, compressed gases, ...
Thenuwara, K., Thomas, J., Ibsen, M., Ituk, U., Choi, K., Nickel, E. & Goodheart, M. J. (2017). Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovahs Witness with life-threatening anemia following postpartum hemorrhage. International Journal of Obstetric Anesthesia, 73-90. DOI: 10.1016/j.ijoa.2016.10.006.. Adam, L. A., Choi, K. C. (2016). Chapter 2: , Laryngoscopy and Endotracheal Intubation. In C. Scott-Conner (Eds.) Essential Operative Techniques & Anatomy. pp. 6-13. Elsevier BV.. Reddy, A., Hitchon, P. W., Al-Nafi, S. & Choi, K. (2015). Entero-paraspinous fistula from recurrent spinal metastatic renal cell carcinoma. Journal of Neurosurgery: Spine, 22(1), 60-3. DOI: 10.3171/2014.10.SPINE14294.. Ahmed, A., Harland, K. K., Hoffman, B., Liao, J., Choi, K. C., Skeete, D. & Denning, G. (2015). Not just an urban phenomenon: Uninsured rural trauma patients at increased risk for mortality. Western Journal of Emergency Medicine, 16(5), 632-41. DOI: ...
The study clearly shows that large amounts of nicotine are delivered rapidly to the bloodstream during use of moist snuff. In fact, venous nicotine concentrations are as high, or higher, than those that have been observed following cigarette smoking. For example, Benowitz et al found that average peak blood nicotine concentrations increased 14.3 ng/ml after smoking one cigarette or using 2.5 g moist snuff for 30 minutes.11Another study found similar increases of 14.5 ng/ml produced by 2 g of Swedish snuff.13 The current study found peak plasma nicotine concentrations increased as much as 19.5 ng/ml after administration of 2.0 g Copenhagen held in the mouth for 30 minutes, and slightly lower amounts, 14.9 ng/ml, produced by Skoal Long Cut Cherry and Skoal Original Wintergreen. Skoal Bandits produced only small increases in peak plasma nicotine concentration, 4.2 ng/ml, an increase not significantly greater than non-tobacco, non-nicotine mint snuff. This relatively small increase in peak plasma ...
The main indoor air pollutant that can cause headaches is carbon monoxide. Environmental tobacco smoke and volatile organic compounds can also cause headaches, but irritant symptoms of the eyes and throat are likely to be more prominent with those sources. The most common symptoms of carbon monoxide inhalation include headache, dizziness, weakness, nausea, difficulty in concentrating, shortness of breath and visual changes. Less frequent symptoms include chest pain, loss of consciousness, abdominal pain and muscle cramping.2 The circulatory and nervous systems are often affected because of their fixed oxygen needs: patients who have inhaled carbon monoxide may present with signs of myocardial ischemia, hypotension, congestive heart failure, arrhythmias, mental confusion, clumsiness, emotional lability, impaired judgement, diminished visual acuity, stupor or coma.20 Carbon monoxide poisoning is considered a "disease with a thousand faces." 20 Its classic mask - cherry-red lips, cyanosis and ...
Masimo (NASDAQ: MASI) announced today the limited market release of Early Warning Score (EWS) on the Root® patient monitoring and connectivity platform. EWS aggregates information from multiple vital signs and clinical observations to generate a score that represents the potential degree of patient deterioration. Root, which works in conjunction with Radical-7® or Radius-7® Pulse CO-Oximeters® and Masimo Open Connect™ (MOC-9™) measurements, features Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, rainbow SET™ pulse CO-Oximetry, Nomoline™ capnography and gas monitoring, SedLine® brain function monitoring, O3™ regional oximetry, and SunTech® blood pressure and Welch Allyn® temperature monitoring. Masimo SET® helps clinicians monitor oxygen saturation and pulse rate during motion and low perfusion for more than 100 million patients a year1 and is the primary pulse oximetry technology at top hospitals, including 9 of the top 10 hospitals listed in the 2016-17 U.S.
This work has been made available to the staff and students of the University of Sydney for the purposes of research and study only. It constitutes material that is held by the University for the purposes of reporting for HERDC and the ERA. This work may not be downloaded, copied and distributed to any third party ...
Masimo Corporation (Nasdaq: MASI), the inventor of Pulse CO-Oximetry(TM) and Measure-Through Motion and Low-Perfusion pulse oximetry, today announced its financial results for the
Abstract: A simple ketoamine 14C-fructosoglycine with all the fructose carbon atoms labelled was synthesized for studies of possible pathways of the ketoamines metabolism in animal body. The ketoamine bond in the fructosoglycine was not hydrolyzed during incubation with homogenates of rabbit liver, kidney, spleen and testicular tissues within 3 hrs at pH 4.8 and 7.3 as well as after hydrolysis with pancreatine (the enzymatic extract from bovine pancreas) at pH 8.4. 14C-fructosoglycine administered into rabbit circulation was mainly excreted with urine (about 70% of the label) within 8-14 days. The main part of the ketoamine was excreted as fructosoglycine and the lower amount--as glycated dipeptide; some amount of fructosoglycine was hydrolyzed liberating fructose or converted into aldimine which was hydrolyzed with formation of glucose. The ketoamine was metabolized also into non-reducing isosucrose-like glucofructoside, insensitive to acid and enzymatic hydrolysis ...
Read the latest Meridian stories, Warnings over dangers of carbon monoxide on ITV News, videos, stories and all the latest Meridian news
The All-Party Parliamentary Carbon Monoxide Group and Policy Connect report identifies that symptoms of carbon monoxide (CO) poisoning are not routinely being detected in the healthcare system.. The All-Party Parliamentary Carbon Monoxide Group, co-chaired by cross bench Peer, Professor the Baroness Finlay of Llandaff, and Huddersfield MP Barry Sheerman, asked a group of health experts to identify ways of improving the diagnosis of CO poisoning. This is due to health figures showing that every year at least 4,000 people in England and Wales attend emergency departments (EDs) as the result of accidental CO poisoning.. Health experts know that CO exposure leads to more than 30 people a year losing their lives and 200 people being admitted to hospital. But it is not yet known how many undiagnosed cases return home, become ill again, or die from continued exposure to CO. The experts believe these figures could be a gross underestimation and the actual cost to the NHS is likely to be much more than ...
The All-Party Parliamentary Carbon Monoxide Group and Policy Connect report identifies that symptoms of carbon monoxide (CO) poisoning are not routinely being detected in the healthcare system.. The All-Party Parliamentary Carbon Monoxide Group, co-chaired by cross bench Peer, Professor the Baroness Finlay of Llandaff, and Huddersfield MP Barry Sheerman, asked a group of health experts to identify ways of improving the diagnosis of CO poisoning. This is due to health figures showing that every year at least 4,000 people in England and Wales attend emergency departments (EDs) as the result of accidental CO poisoning.. Health experts know that CO exposure leads to more than 30 people a year losing their lives and 200 people being admitted to hospital. But it is not yet known how many undiagnosed cases return home, become ill again, or die from continued exposure to CO. The experts believe these figures could be a gross underestimation and the actual cost to the NHS is likely to be much more than ...
Carbon Monoxide In The Bridgewall - posted in Industrial Professionals: Hello. Are there any standards determining what is the maksimum carbon monoxide level at which furnace can be sefety operating? Theory say that combustion is optimal with 100-150 ppm of CO in the bridgewall. But is this CO concentration also a border above which work of the furnace is unsafe? Regards
If we look at the celebrities that weve known on the big-screen over the years, we can see that life has a way of naturally plumping us out. Those who held a thin or normal pounds in their younger years almost-always put on a few after reaching their late middle age years of life.. Because many celebrities who have been substantially overweight have lived into their 90s, this gives us the common sense to know that our genes and heredity are the largest indicators which determine our life span.. The beloved Bob Hope put on a few pounds in his older years and lived to the ripe age of 100. George Burns was an avid cigar smoker yet lived to 100. Leon Askin who played General Burkhalter on Hogans Heroes and who was significantly overweight lived to be 95. Mae West who grew plump in her ageing years lived way into her 80s. These wonderful individuals are just a handful of examples which show us that length of life has much more to do with other things than solely the number we see on our bathroom ...
A CO concentration monitoring device operating under the control of a processor periodically checks the CO sensor to insure its ongoing integrity and to issue a distinctive audio signal to a user if sensor integrity has become suspect. The periodic integrity check procedure places a predetermined DC voltage across the sensor. Then, the voltage source is removed leaving the sensor charged as a capacitor such that reading the voltage remaining across the sensor, reading the temperature of the sensor and comparing a temperature adjusted representation of the voltage appearing across the sensor to at least one predetermined representation of a voltage representing a threshold at which sensor integrity becomes suspect. If this condition is determined, a sensor condition alert signal responsive is issued to drive a horn in a distinctive audio sequence (e.g., three 10 millisecond duration pulses spaced at about 500 millisecond intervals). In an optional feature, a manually actuable switch serves to selectively
Question - My hematrocrit is at 49.5, hemoglobin at 16.4, MCH 35.8 and - HU. Find the answer to this and other Medical questions on JustAnswer
The New Hampshire Fire Marshals Office says 45-year-old Michael Vanderkieft died at Massachusetts General Hospital after high carbon monoxide levels were found at his Nashua home.
TY - JOUR. T1 - Effect of magnesium on preferential oxidation of carbon monoxide on platinum catalyst in hydrogen-rich stream. AU - Cho, Sung Ho. AU - Park, Jong Soo. AU - Choi, Seung Hoon. AU - Kim, Sung Hyun. PY - 2006/6/1. Y1 - 2006/6/1. N2 - The effects of magnesium on platinum catalyst used for the preferential oxidation of carbon monoxide for polymer electrolyte membrane fuel cell applications are investigated. The CO conversion and selectivity on Pt-Mg/Al2O3 for a H2-rich stream are 93.1 and 62.0%, respectively, but only 70.2 and 46.89% on Pt/Al2O3. The superior activity of Pt-Mg/Al2O3 for the preferential oxidation of CO is due to an increase in the hydroxyl groups that results from an increase in basicity with the addition of Mg, as well as to an increase in the electron density on the surface of the Pt catalyst. Moreover, the content of hydroxyl groups on the Pt catalysts is promoted by water vapour.. AB - The effects of magnesium on platinum catalyst used for the preferential ...
The Invisible Killer (pdf). Reviews sources of carbon monoxide (CO) and clues to a possible carbon monoxide problem in the home.. Portable Generator Danger. Links to posters, safety cards, door hangers, safety alerts and public service announcements all aimed at promoting safety with generators and reducing CO deaths.. What to Know: Generators and CO. Safety tips to use when using portable generators.. Carbon Monoxide Poisoning from Camping Equipment (pdf). A safety alert discussing carbon monoxide (CO) poisoning from camping equipment such as portable camping heaters, lanterns, stoves, campers and vehicles. Also, provides prevention advice and information on how to recognize the symptoms of CO poisoning.. Responding to Residential Carbon Monoxide Incidents (pdf). A guide to first responders on dealing with incidents of carbon monoxide exposure.. Inspect, Detect and Protect Against Carbon Monoxide Poisoning (En Español). Protect your family from carbon monoxide poisoning. Install CO alarms in ...
The Invisible Killer (pdf). Reviews sources of carbon monoxide (CO) and clues to a possible carbon monoxide problem in the home.. Portable Generator Danger. Links to posters, safety cards, door hangers, safety alerts and public service announcements all aimed at promoting safety with generators and reducing CO deaths.. What to Know: Generators and CO. Safety tips to use when using portable generators.. Carbon Monoxide Poisoning from Camping Equipment (pdf). A safety alert discussing carbon monoxide (CO) poisoning from camping equipment such as portable camping heaters, lanterns, stoves, campers and vehicles. Also, provides prevention advice and information on how to recognize the symptoms of CO poisoning.. Responding to Residential Carbon Monoxide Incidents (pdf). A guide to first responders on dealing with incidents of carbon monoxide exposure.. Inspect, Detect and Protect Against Carbon Monoxide Poisoning (En Español). Protect your family from carbon monoxide poisoning. Install CO alarms in ...
We read with interest the report by Satran et al. (1) on the cardiovascular manifestations of carbon monoxide (CO) poisoning. In the Hospital Rı́o Hortega of Valladolid (Spain), we followed CO poisonings prospectively for two years (2). The protocol included, among other parameters, carboxyhemoglobin (COHb) levels, electrocardiogram (ECG), creatine kinase (CK) and CK-MB. During the study period studied, 154 patients were included, of whom 20% (n = 31) presented sinusal tachycardia, 5% (n = 8) arrhythmias (mainly auricular fibrillation), and 4% (n = 6) ischemic changes, including one patient in whom cardiac catheterization was carried out without findings of coronary artery disease. Eight (7.2%) adult patients and 25.6% (n = 10) of patients under 10 years of age had elevated CK levels. Similarly, CK-MB levels were elevated in 1.8% (n = 2) of adults and in 12.7% (n = 5) of children (p , 0.01) (2). In our series, the percentage of patients with cardiovascular manifestations is inferior to that ...
The majority of carbon monoxide exposures occur in the winter months and the most common source of residential CO-related poisoning is unvented supplemental heaters. An unvented supplemental heater is a type of space heater that uses combustible fuel and indoor air for the heating process and vents the gases produced in the heating process out into the room (instead of to the outdoors). Thus, a space heater that is improperly installed or not functioning properly can introduce carbon monoxide and other toxic fumes into the room and use up much of the oxygen in the room.. Most supplemental heaters of this type use kerosene or natural gas for fuel. While newer models have oxygen sensors that shut off the heater when the oxygen level in the room falls below a certain level, older models do not have such safety features. Because of these safety problems, unvented space heaters have been banned in several states.. Other common sources of carbon monoxide include the following:. ...
Dubbed the "silent killer" because it is colorless, odorless, nonirritating and tasteless, carbon monoxide gas is highly toxic and exposure to it is the leading cause of accidental poisoning in the United States. Not only are carbon monoxide exposure cases on the rise and garnering large damage awards, even low-level exposure cases are demanding seven-figure settlements for brain damage and cognitive impairment-awards that can bankrupt a business.. Aided by advanced imaging and neuropsychological testing, aggressive plaintiffs lawyer are presenting high-tech evidence in support of staggering damage claims and juries are ready and willing to grant the requested awards. Targeting building owners, building associations, architects, contractors, landlords, facility managers, HVAC engineers and even equipment manufacturers when claims arise, plaintiffs lawyers are bringing individual actions as well as filing mass tort actions, pursuing many more and far larger cases.. ...
A recent mass casualty event in Fairfax County, Va., serves as a reminder for employers to take the necessary precautions to protect workers from the serious, and sometimes fatal, effects of carbon monoxide exposure.
Oliveira SR, Figueiredo-Pereira C, Duarte CB, Vieira HLA (2019) P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes-Transcriptomic Study. Molecular Neurobiology (in press). Dias-Pedroso D, Guerra J, Gomes A, Oudot C, Brenner C, Santos CN, Vieira HLA (2019) Phenolic metabolites modulate cardiomyocyte beating in response to isoproterenol. Cardiovascular Toxicology 19(2):156-167. Almeida AS, Soares NL, Sequeira CO, Pereira SA, Sonnewald U, Vieira HLA (2018) Improvement of neuronal differentiation by carbon monoxide: role of pentose phosphate pathway. Redox Biology 17:338-347. Dreyer-Andersen N, Almeida AS, Jensen P, Kamand M. Okarmus J, Rosenberg T, Friis SD, Martínez Serrano A, Blaabjerg M, Kristensen BW, Skrydstrup T, Gramsbergen JB, Vieira HLA, Meyer M (2018) Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells. PlosONE 13(1):e0191207. Santos CN, Gomes A, Oudot C, Dias-Pedroso ...
TY - JOUR. T1 - Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets. AU - Chang, Wen Chang. AU - Fukuda, Shoshi. AU - Tai, Hsin Hsiung. PY - 1983/9/15. Y1 - 1983/9/15. N2 - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.. AB - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of ...
The ADT® monitored carbon monoxide detector continually senses carbon monoxide in the air with a range of 35-5,000 parts per million (PPM). When the carbon monoxide detector senses 70 PPM or more, the sensors alarm is triggered. By contrast, the first symptoms of carbon monoxide poisoning, generally slight headaches or flu-like symptoms come on at 100 PPM. The carbon monoxide detector with ADT® monitoring, when used properly, allows for early detection before carbon monoxide poisoning sets in.. This state of the art carbon monoxide detector is equipped with an 85 decibel alarm at 10 feet. The loud alert is used to notify anyone in your home of carbon monoxide buildup. The ADT® monitored carbon monoxide detector is different from the competition because it communicates with the home security panel and alerts ADT® monitoring of increased level of carbon monoxide. ADT® then follows up on the issue and will contact emergency services, as desired. This means that your familys safety isnt ...
Exposing an Invisible Killer (PDF, 155 Kb). Each year in America, unintentional carbon monoxide poisoning claims more than 500 lives and sends another 15,000 people to hospital emergency rooms for treatment.1. The United States Fire Administration (USFA) and the National Association of Home Builders (NAHB) would like you to know that there are simple steps you can take to protect yourself from deadly carbon monoxide fumes.. Understanding the Risk What is carbon monoxide?. Carbon monoxide is an odorless, colorless and toxic gas. Because it is impossible to see, taste or smell the toxic fumes, CO can kill you before you are aware it is in your home. At lower levels of exposure, CO causes mild effects that are often mistaken for the flu. These symptoms include headaches, dizziness, disorientation, nausea and fatigue. The effects of CO exposure can vary greatly from person to person depending on age, overall health and the concentration and length of exposure.. Where does carbon monoxide come ...
Whats wrong with CO? Chapter 14 (Air Quality) of the FEIS explains: CO, a colorless and odorless gas, is produced in the urban environment primarily by the incomplete combustion of gasoline and other fossil fuels. In urban areas, approximately 80 to 90 percent of CO emissions are from motor vehicles. Since CO is a reactive gas that does not persist in the atmosphere, CO concentrations can vary greatly over relatively short distances. Elevated concentrations are usually limited to locations near crowded intersections, heavily traveled and congested roadways, parking lots, and garages. Consequently, CO concentrations must be predicted on a local, or microscale, basis. ...
Dear Friend,. Carbon monoxide (CO) is a deadly gas, made all the more dangerous because it is odorless, tasteless, colorless and non-irritating. Because the initial symptoms of carbon monoxide poisoning mimic the flu, many victims are not even aware they are being exposed. According to the National Center for Disease Control (CDC) more than 500 Americans die every year from unintentional carbon monoxide poisoning and another 15,000 seek medical attention after being exposed to the gas. Fortunately, there are ways to avoid these senseless tragedies.. Inside is information about carbon monoxide, as well as safety precautions you can take to reduce your risk of carbon monoxide poisoning. As always, please feel free to contact me if I can be of any assistance. ...
Carbon Monoxide The presence of carbon monoxide (CO) in our homes is dangerous. So, how can you protect your family from carbon monoxide? How do you choose the right CO detector for your home? The first step is to make sure that carbon monoxide never enters your home. The second step is to install at least one CO detector in your home. This About Your House answers often-asked questions about carbon monoxide to help you make the right decision to make your home safe. What Is Carbon Monoxide? Carbon monoxide (CO) is a colourless and odourless gas. Because you cant see, taste or smell it, it can affect you or your family before you even know its there. Even at low levels of exposure, carbon monoxide can cause serious health problems. CO is harmful because it will rapidly accumulate in the blood, depleting the ability of blood to carry oxygen.1 Where Does Carbon Monoxide Come From? Carbon monoxide is a common byproduct of the combustion (burning) of fossil fuels. Most fuel-burning equipment ...
Carbon Monoxide Poisoning Abstract: Carbon monoxide (CO) is a colorless, odorless and deadly gas produced by the incomplete burning of fossil fuels used in appliances such as furnaces and portable gas generators. As the cold weather approaches, here are some tips to prevent carbon monoxide build-up in your home:Have a carbon monoxide detector in your home. ...
As it is evident from above that leakage of carbon monoxide is a serious situation. And by no means will you ever be able to keep a check on this leakage on your own. Only professional duct cleaners, equipped with the right tools, can figure out if your duct is leaking carbon monoxide. Carbon monoxide leakage is risky for you and your loved ones. Therefore, it is very important to hire the experts to keep a check on it.. At Marks Duct Cleaning we provide FREE duct carbon monoxide testing with our duct cleaning services. We always follow the guidelines of Energy Safe Australia to deliver nothing but the best to our customers.. ...
I am a 24 year old uninsured otherwise healthy athsmatic. I have been using a rescue inhaler since I was 5 and I have never had to use it multiple times a day unless i was doing sports, or was sick with broncitis. I recently was suprised when I had to go to the emergency room to get a new inhaler, because I finally ran out of the one I had for over a year. I was given some HFA piece of junk. This was three months ago, and I need to use it almost ten times a day. I have had three new inhalers since then, and I cant imagine what this is doing to my body. I can no longer perform my work duties correctly anymore, and I dont know what to do. I am 24 and Im breathing as if I was a 97 year old cigar smoker. I cant even sleep through an entire night without waking up in need for a rescue. Oh yeah, not to mention that these pieces of crap dont even work within less than 5 minutes. I am willing to do anything for one of my old inhalers. It would last me for years and cost me thousands less. Please ...
I am a 24 year old uninsured otherwise healthy athsmatic. I have been using a rescue inhaler since I was 5 and I have never had to use it multiple times a day unless i was doing sports, or was sick with broncitis. I recently was suprised when I had to go to the emergency room to get a new inhaler, because I finally ran out of the one I had for over a year. I was given some HFA piece of junk. This was three months ago, and I need to use it almost ten times a day. I have had three new inhalers since then, and I cant imagine what this is doing to my body. I can no longer perform my work duties correctly anymore, and I dont know what to do. I am 24 and Im breathing as if I was a 97 year old cigar smoker. I cant even sleep through an entire night without waking up in need for a rescue. Oh yeah, not to mention that these pieces of crap dont even work within less than 5 minutes. I am willing to do anything for one of my old inhalers. It would last me for years and cost me thousands less. Please ...
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We have used isoelectric focusing to measure the differences between the pI values of various normal and mutant human haemoglobins when completely deoxygenated and when fully liganded with CO. It was assumed that the ΔpI(deox.-ox.) values might correspond quantitatively to the intrinsic alkaline Bohr effect, as most of the anionic cofactors of the haemoglobin molecule are stripped off during the electrophoretic process. In haemoglobins known to exhibit a normal Bohr coefficient (ΔlogP50/ΔpH) in solutions, the ΔpI(deox.-ox.) values are lower the higher their respective pI(ox.) values. This indicates that for any particular haemoglobin the ΔpI(deox.-ox.) value accounts for the difference in surface charges at the pH of its pI value. This was confirmed by measuring, by the direct-titration technique, the difference in pH of deoxy and fully liganded haemoglobin A0 (α2β2) solutions in conditions approximating those of the isoelectric focusing, i.e. at 5°C and very low concentration of KCl. ...
GRAND RAPIDS, MI, September 21, 2016 - Fireboy-Xintex is releasing a new carbon monoxide alarm system to be displayed at The International BoatBuilders Exhibition and Conference (IBEX) this October 4-6, 2016 at the Tampa Convention Center.. The new CMD5-M Carbon Monoxide Alarm features an electrochemical sensor, compact design, and a version that requires no external power to be fully functional. Keith Larson, Vice President/Sales & Marketing at Fireboy-Xintex, is eager for boat builders to examine the battery powered version hailing that its "an industry first. No wiring required!" The wire-free option allows for easy installation and is incredibly cost effective. Regarding the electrochemical sensor, Larson notes its "state-of-the-art technology" which results in immediate and stable sensing for reducing false alarms. The sensor utilizes a microprocessor to measure carbon monoxide levels and calculates the Carboxyhemoglobin as a function of time to determine the appropriate alarm ...
The binding of CO to ascorbate-reduced Pseudomonas cytochrome oxidase was investigated by static-titration, stopped-flow and flash-photolytic techniques. Static-titration data indicated that the binding process was non-stoicheiometric, with a Hill number of 1.44. Stopped-flow kinetics obtained on the binding of CO to reduced Pseudomonas cytochrome oxidase were biphasic in form; the faster rate exhibited a linear dependence on CO concentration with a second-order rate constant of 2 × 10(4) M-1-s-1, whereas the slower reaction rapidly reached a pseudo-first-order rate limit at approx. 1s-1. The relative proportions of the two phases observed in stopped-flow experiments also showed a dependency on CO concentration, the slower phase increasing as the CO concentration decreased. The kinetics of CO recombination after flash-photolytic dissociation of the reduced Pseudomonas cytochrome oxidase-CO complex were also biphasic in character, both phases showing a linear pseudo-first-order rate dependence ...
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Pulse oximetry probes placed peripherally may fail to give accurate values of blood oxygen saturation when the peripheral circulation is poor. Because central blood flow may be preferentially preserved, we investigated the oesophagus as an alternative monitoring site. A reflectance blood oxygen saturation probe was developed and evaluated in 49 patients undergoing cardiothoracic surgery. The oesophageal pulse oximeter results were in good agreement with oxygen saturation measurements obtained by a blood gas analyser, a CO-oximeter and a commercial finger pulse oximeter. The median (IQR [range]) difference between the oesophageal oxygen saturation results and those from blood gas analysis were 0.00 (-0.30 to 0.30 [-4.47 to 2.60]), and between the oesophageal oxygen saturation results and those from CO-oximetry were 0.75 (0.30 to 1.20 [-1.80 to 1.80]). Bland-Altman analysis showed that the bias and the limits of agreement between the oesophageal and finger pulse oximeters were -0.3% and -3.3 to ...
Objectives: Exposure to air pollution is associated with numerous impacts on health, including neurodevelopmental function. The purpose of this study was to estimate the magnitude of air pollution exposure based on environmental carbon monoxide (CO) measures and assessment of 1-hydroxypyrene (1-OHP), a metabolite of polycyclic aromatic hydrocarbons (PAHs), among school-aged HIV-infected and uninfected children in peri urban Kenya and to examine the impacts of these exposures on neurodevelopment. Methods: We conducted a cross sectional study of 49 HIV uninfected unexposed (HUU) and 45 HIV infected children ages 5-9 and their caregivers in Nairobi, Kenya. We used a battery of neurodevelopmental tests to assess function in 9 domains. Caregiver 24-h personal CO exposure was a proxy for child exposure, and measured child urinary 1-OHP. Results: Mean 24-h CO exposure was 8.15 ±13.46 ppm and mean urine 1-OHP was 0.81±0.60 µmol/mol creatinine. Overall, 39.4% of children had mean CO exposure ,WHO ...

Cerebrovascular ischaemia after carbon monoxide intoxication | SMJCerebrovascular ischaemia after carbon monoxide intoxication | SMJ

Carboxyhaemoglobin level improved from Day 1 to Day 2 of hospital stay, while the levels of troponin I and creatine kinase-MB ... Although our patient was unconscious and had an elevated carboxyhaemoglobin level and a low Glasgow Coma Scale score, ... Hyperbaric oxygen treatment may be required in patients who have severe carbon monoxide intoxication or carboxyhaemoglobin ... creatine kinase-MB fraction and carboxyhaemoglobin levels, and left ventricular dysfunction). Visual field defect is a ...
more infohttp://www.smj.org.sg/article/cerebrovascular-ischaemia-after-carbon-monoxide-intoxication

Carboxyhemoglobin Elevation after Exposure to Dichloromethane | ScienceCarboxyhemoglobin Elevation after Exposure to Dichloromethane | Science

Carboxyhemoglobin Elevation after Exposure to Dichloromethane. By Richard D. Stewart, Terrance N. Fisher, Michael J. Hosko, ... Carboxyhemoglobin Elevation after Exposure to Dichloromethane. By Richard D. Stewart, Terrance N. Fisher, Michael J. Hosko, ... Carboxyhemoglobin Elevation after Exposure to Dichloromethane Message Subject. (Your Name) has forwarded a page to you from ...
more infohttp://science.sciencemag.org/content/176/4032/295

Plus itPlus it

Variations in Carboxyhaemoglobin Levels in Smokers Br Med J 1974; 4 :736 ... Three experiments on smokers have been performed to determine variations in blood levels of carboxyhaemoglobin (COHb) ... Variations in Carboxyhaemoglobin Levels in Smokers. Br Med J 1974; 4 doi: https://doi.org/10.1136/bmj.4.5947.736 (Published 28 ...
more infohttp://www.bmj.com/content/4/5947/736

Carboxyhemoglobin - WikipediaCarboxyhemoglobin - Wikipedia

Carboxyhemoglobin or carboxyhaemoglobin (symbol COHb or HbCO) is a stable complex of carbon monoxide and hemoglobin (Hb) that ... This process produces a certain amount of carboxyhemoglobin in normal persons, even if they do not breathe any carbon monoxide ... Carboxyhemoglobin at the US National Library of Medicine Medical Subject Headings (MeSH). ... Gregory B. Vásquez; Xinhua Ji; Clara Fronticelli; Gary L. Gilliland (1998). "Human Carboxyhemoglobin at 2.2 Å Resolution: ...
more infohttps://en.wikipedia.org/wiki/Carboxyhemoglobin

Carboxyhaemoglobin levels in workers in Leicestershire garages. | Occupational & Environmental MedicineCarboxyhaemoglobin levels in workers in Leicestershire garages. | Occupational & Environmental Medicine

Blood carboxyhaemoglobin (HbCO%) levels were measured in 61 workers in 35 garages in Leicester and Leicestershire. Of 26 ...
more infohttp://oem.bmj.com/content/36/3/238

Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis - Full Text View - ClinicalTrials.govMeasurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis - Full Text View - ClinicalTrials.gov

Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis. The safety and scientific validity of this ... Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis in ABO-compatible and Incompatible Healthy Term ... A very accurate and reliable laboratory measure of red blood cell destruction is the plasma carboxyhemoglobin level (COHb). ...
more infohttps://clinicaltrials.gov/ct2/show/NCT00917007?recr=Open&cond=%22Fetal+Diseases%22&rank=11

COMPLICATIONS RELATED CARBOXYHEMOGLOBIN LEVELS IN SECOND HAND SMOKING PEDIATRIC TONSILLECTOMY PATIENTS - Full Text View -...COMPLICATIONS RELATED CARBOXYHEMOGLOBIN LEVELS IN SECOND HAND SMOKING PEDIATRIC TONSILLECTOMY PATIENTS - Full Text View -...

COMPLICATIONS RELATED CARBOXYHEMOGLOBIN LEVELS IN SECOND HAND SMOKING PEDIATRIC TONSILLECTOMY PATIENTS. The safety and ... Correlation between carboxyhemoglobin levels and pain of the second hand smoking children [ Time Frame: postoperative 24 hours ... Correlation between carboxyhemoglobin levels of the second hand smoking children and intraoperative bleeding volume [ Time ... The purpose of this study was to determine whether high carboxyhemoglobin level is a risk factor for postoperative adverse ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01942252?term=%22secondhand+smoke%22&recr=Open&rank=5

Carboxyhaemoglobin levels in water-pipe and cigarette smokersCarboxyhaemoglobin levels in water-pipe and cigarette smokers

The carboxyhaemoglobin (COHb) level in the blood (half-life 2 -6 hours) after inhalation of CO will depend on concentrations of ... Carboxyhaemoglobin concentrations in smokers of zheesha and cigarettes in Saudi Arabia. BMJ 1985; 291: 1768-1770. [ Links ]. ... AIM: We aimed to measure carboxyhaemoglobin (COHb) blood levels before and after water-pipe and cigarette smoking sessions. ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742010000200021&lng=pt&nrm=iso&tlng=en

Carboxyhaemoglobin levels in water-pipe and cigarette smokersCarboxyhaemoglobin levels in water-pipe and cigarette smokers

The carboxyhaemoglobin (COHb) level in the blood (half-life 2 -6 hours) after inhalation of CO will depend on concentrations of ... Carboxyhaemoglobin concentrations in smokers of zheesha and cigarettes in Saudi Arabia. BMJ 1985; 291: 1768-1770. [ Links ]. ... AIM: We aimed to measure carboxyhaemoglobin (COHb) blood levels before and after water-pipe and cigarette smoking sessions. ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742010000200021&lng=en&nrm=iso

Prevalence of Causes of Symptom: Elevated carboxyhaemoglobin  - RightDiagnosis.comPrevalence of Causes of Symptom: Elevated carboxyhaemoglobin - RightDiagnosis.com

Prevalence or incidence of diseases and medical conditions possibly causing symptom Elevated carboxyhaemoglobin as a symptom, ... Related medical articles for symptom Elevated carboxyhaemoglobin: *Symptom: Elevated carboxyhaemoglobin *Possible causes of ... Elevated carboxyhaemoglobin type of: Red blood cell symptoms (849 causes), Blood symptoms (2053 causes), Abnormal blood test ... Symptoms related to Elevated carboxyhaemoglobin: Carbon monoxide poisoning, Carbon dioxide, Oxy haemoglobin, Suffocation (3 ...
more infohttps://www.rightdiagnosis.com/symptoms/elevated_carboxyhaemoglobin.htm

Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke...Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke...

Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke ... as well as carboxyhemoglobin (COHb) and expired carbon monoxide (COex) were determined. All tobacco smoke uptake parameters ( ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/3258284?dopt=Abstract

Method for noninvasive (in-vivo) total hemoglobin, oxyhemogolobin, deoxyhemoglobin, carboxyhemoglobin and methemoglobin...Method for noninvasive (in-vivo) total hemoglobin, oxyhemogolobin, deoxyhemoglobin, carboxyhemoglobin and methemoglobin...

Method for noninvasive (in-vivo) total hemoglobin, oxyhemogolobin, deoxyhemoglobin, carboxyhemoglobin and methemoglobin ... At 548 nm, there is a triple isosbestic point for oxy-, deoxy- and carboxyhemoglobin. At this point these species have an ... In addition, a triple isosbestic point for oxy-, deoxy-, and carboxyhemoglobin is apparent at 548 nm. At this point, the ... The Coming Co-Oximeter 2500 measures total hemoglobin, oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, methemoglobin and ...
more infohttp://www.freepatentsonline.com/5692503.html

Elevated carboxyhemoglobin in a marine mammal, the northern elephant seal | Scripps Institution of Oceanography, UC San DiegoElevated carboxyhemoglobin in a marine mammal, the northern elephant seal | Scripps Institution of Oceanography, UC San Diego

Elevated carboxyhemoglobin in a marine mammal, the northern elephant seal Elevated carboxyhemoglobin in a marine mammal, the ... However, high concentrations of carboxyhemoglobin (COHb), formed by CO binding to hemoglobin, potentially prevent adequate O-2 ...
more infohttps://scripps.ucsd.edu/biblio/elevated-carboxyhemoglobin-marine-mammal-northern-elephant-seal

Carboxyhemoglobin and Methemoglobin as Markers of Postoperative Pulmonary ComplicationsCarboxyhemoglobin and Methemoglobin as Markers of Postoperative Pulmonary Complications

Postoperative carboxyhemoglobin was higher in smokers compared to control non-smokers group (p = 0.000). On the other hand, ... In both groups carboxyhemoglobin and methemoglobin levels were determined preoperatively, after preoxygenation, and one hour ... Determination of the level of carboxyhemoglobin and methemoglobin can identify patients with increased risk for development of ... we cannot confirm the hypothesis that carboxyhemoglobin and methemoglobin can serve as predictors for postoperative pulmonary ...
more infohttps://www.ommegaonline.org/article-details/Carboxyhemoglobin-and-Methemoglobin-as-Markers-of-Postoperative-Pulmonary-Complications/1828

Carboxyhaemoglobin)? - ?????   ?????????   ???????  999Carboxyhaemoglobin)? - ????? ????????? ??????? 999

???????????????? (Carboxyhaemoglobin) - ???????? ??????????, ?????? ??? ??? ????????????? ??? ???????? ??????? ?????? ??? ????????????. ???????????????? ??????? ?????????? ?????? ???? ?????????, ??????? ??? ????????? ??? ???????? ??????? ??? ??? ??????? ???? . ??? ?????????? ???????????????? ????????? ??? ????????? ??? ????????, ?????? ?????? ??????????? ??? ??????? ?????? ??? ?????? ?????? ?????? .
more infohttp://www.tridevyatki.ru/lib/index.php?chapter=376&word=32963

Spectrophotometric measurement of carboxyhemoglobin and methem...Spectrophotometric measurement of carboxyhemoglobin and methem...

Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood.: This paper describes separate ... Spectrophotometric measurement of carboxyhemoglobin and methemoglobin in blood.. Authors * Rodkey, F L ... This paper describes separate spectrophotometric procedures for rapidly measuring carboxyhemoglobin (COHb) and methemoglobin ( ...
more infohttps://www.mysciencework.com/publication/show/spectrophotometric-measurement-carboxyhemoglobin-methemoglobin-blood-736bbb9c

Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting<...Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting<...

Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting. / Kurt, T. L.; Anderson, R. J.; Reed, G. ... Kurt, T. L. ; Anderson, R. J. ; Reed, G. / Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting. In ... Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting. Veterinary and Human Toxicology. 1990;32(3): ... Kurt, TL, Anderson, RJ & Reed, G 1990, Rapid estimation of carboxyhemoglobin by breath sampling in an emergency setting, ...
more infohttps://utsouthwestern.pure.elsevier.com/en/publications/rapid-estimation-of-carboxyhemoglobin-by-breath-sampling-in-an-em

Blood carboxyhemoglobin monitoring for evaluation of severity of traumatic shock and reperfusion injuries (analytical review...Blood carboxyhemoglobin monitoring for evaluation of severity of traumatic shock and reperfusion injuries (analytical review...

Blood carboxyhemoglobin monitoring for evaluation of severity of traumatic shock and reperfusion injuries (analytical review ... The carboxyhemoglobin blood concentration in traumatic shock may be very increased. CO level and carboxyhemoglobin blood ... Carboxyhemoglobin blood concentration no more than 4 % was presented in the majority of foreign investigations in patients in ... Arterial carboxyhemoglobin level and outcome in critically ill patients.Critical Care Medicine. 2007 Aug; 35(8):1882-7. ...
more infohttp://emergency.zaslavsky.com.ua/article/view/94449

Body mass Index, Markers of airway inflammation, and carboxy hemoglobin levels of Chronic Obstructive Pulmonary Disease...Body mass Index, Markers of airway inflammation, and carboxy hemoglobin levels of Chronic Obstructive Pulmonary Disease...

Body mass Index, Markers of airway inflammation, and carboxy hemoglobin levels of Chronic Obstructive Pulmonary Disease ... the level of inflammation of airways and breath carboxy hemoglobin (bCO) levels of Sri Lankan COPD patients are unknown. ...
more infohttp://journals.sjp.ac.lk/index.php/ASS/article/view/4168

EF | definition of EF by Medical dictionaryEF | definition of EF by Medical dictionary

carboxyhemoglobin fraction. The percentage of total hemoglobin in a blood sample that is covalently bonded to carbon monoxide. ... 2. The ratio of a component to the total, e.g., the substance fraction of carboxyhemoglobin (relative to the total hemoglobin). ...
more infohttps://medical-dictionary.thefreedictionary.com/ef

EFS | definition of EFS by Medical dictionaryEFS | definition of EFS by Medical dictionary

carboxyhemoglobin fraction. The percentage of total hemoglobin in a blood sample that is covalently bonded to carbon monoxide. ... 2. The ratio of a component to the total, e.g., the substance fraction of carboxyhemoglobin (relative to the total hemoglobin). ...
more infohttps://medical-dictionary.thefreedictionary.com/EFS

Carbon monoxide poisoningCarbon monoxide poisoning

Carboxyhemoglobin. Levels of carbon monoxide bound in the blood can be determined by measuring carboxyhemoglobin, which is a ... Normal carboxyhemoglobin levels in an average person are less than 5%, whereas cigarette smokers (two packs/day) may have ... Serious toxicity is often associated with carboxyhemoglobin levels above 25%, and the risk of fatality is high with levels over ... Hemoglobin acquires a bright red color when converted to carboxyhemoglobin, so a casualty of CO poisoning is described in ...
more infohttps://www.bionity.com/en/encyclopedia/Carbon_monoxide_poisoning.html

Carbon Monoxide Safety | Taylor, MICarbon Monoxide Safety | Taylor, MI

Carboxyhemoglobin (COHb). Carboxyhemoglobin can cause headaches, fatigue, nausea, dizzy spells, confusion and irritability. ... When CO is breathed in by an individual, it accumulates in the blood and forms a toxic compound known as carboxyhemoglobin ( ... seek medical treatment or get a carboxyhemoglobin level blood test for CO poisoning. Some of the symptoms can also include are: ...
more infohttps://www.cityoftaylor.com/289/Carbon-Monoxide-Safety

Hemolytic anemia | Lima Memorial Health SystemHemolytic anemia | Lima Memorial Health System

Carboxyhemoglobin level. Carboxyhemoglobin level. Hemoglobin derivatives are altered forms of hemoglobin. Hemoglobin is a ...
more infohttps://www.limamemorial.org/health-library/HIE%20Multimedia/1/000571

Air pollution control and the occurrence of acute respiratory illness in school children of Quito, Ecuador | SpringerLinkAir pollution control and the occurrence of acute respiratory illness in school children of Quito, Ecuador | SpringerLink

ARI incidence, carboxyhemoglobin, and CO. In 2007, neither ambient CO concentrations (Table 3) nor levels of COHb (Table 4) ... Carboxyhemoglobin status. Before starting the follow-up period, we obtained a 5-mL venous blood sample from each child using a ... ARI incidence and carboxyhemoglobin levels. While there was no difference in the percentage of children who presented with ARI ... Acute respiratory illness Policy emission control Carboxyhemoglobin Electronic supplementary material. The online version of ...
more infohttps://link.springer.com/article/10.1057/s41271-018-0148-6
  • Currently, many investigators consider an endogenous CO and carboxyhemoglobin production in critical states as a compensatory mechanism that promotes cytoprotection and contributes to patients' survivability. (zaslavsky.com.ua)
  • Thus, excessive endogenous CO production and excessive carboxyhemoglobin generation may play a significant role in tissue damage and multiorgan dysfunction formation. (zaslavsky.com.ua)
  • The average values of carboxyhemoglobin between the two groups were statistically significantly different. (ommegaonline.org)