A systemic agricultural fungicide and seed treatment agent.
Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc.
Cytochromes of the b group that have alpha-band absorption of 563-564 nm. They occur as subunits in MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III.
NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distinguished by their sensitivity to various inhibitors. EC 1.6.99.2 (NAD(P)H DEHYDROGENASE (QUINONE);) is a flavoprotein which reduces various quinones in the presence of NADH or NADPH and is inhibited by dicoumarol. EC 1.6.99.5 (NADH dehydrogenase (quinone)) requires NADH, is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives. EC 1.6.99.6 (NADPH dehydrogenase (quinone)) requires NADPH and is inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.
A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
A species of bacteria isolated from soil.

Succinate:quinone oxidoreductase in the bacteria Paracoccus denitrificans and Bacillus subtilis. (1/16)

An overview of the present knowledge about succinate:quinone oxidoreductase in Paracoccus denitrificans and Bacillus subtilis is presented. P. denitrificans contains a monoheme succinate:ubiquinone oxidoreductase that is similar to that of mammalian mitochondria with respect to composition and sensitivity to carboxin. Results obtained with carboxin-resistant P. denitrificans mutants provide information about quinone-binding sites on the enzyme and the molecular basis for the resistance. B. subtilis contains a diheme succinate:menaquinone oxidoreductase whose activity is dependent on the electrochemical gradient across the cytoplasmic membrane. Data from studies of mutant variants of the B. subtilis enzyme combined with available crystal structures of a similar enzyme, Wolinella succinogenes fumarate reductase, substantiate a proposed explanation for the mechanism of coupling between quinone reductase activity and transmembrane potential.  (+info)

Construction of a homologous selectable marker gene for Lentinula edodes transformation. (2/16)

We cloned a gene for the iron sulfur protein (Ip) subunit from an edible mushroom, Lentinula edodes, and introduced a point mutation that confers carboxin resistance into it. The mutant gene successfully transformed L. edodes with high efficiency (9 transformants/2.5 microg vector DNA). Restriction enzyme-mediated integration (REMI) increased the transformation efficiency by about two-fold.  (+info)

Effect of the systemic fungicide carboxin on electron transport function in membranes of Micrococcus denitrificans. (3/16)

The systemic fungicide carboxin (5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide) inhibited oxidation of succinate by membranes prepared from Micrococcus denitrificans, the K(i) being 16 muM. Oxycarboxin (5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide-4,4-dioxide), F831 (5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide-4-oxide), and another succinate oxidase inhibitor, 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (TTB) were less effective inhibitors of succinate oxidation by membranes of M. denitrificans. Oxidation of other substrates (nicotinamide adenine dinucleotide, reduced form, d-lactate, l-lactate, malate, and d,l-alpha-hydroxybutyrate) was inhibited to a lesser degree by carboxin, and formate oxidation was entirely resistant. With all substrates tested, oxycarboxin, the dioxide analogue of carboxin, was less effective than carboxin. Carboxin also inhibited dichlorophenol indophenol (DCIP) reductase activities by these membranes in a manner both qualitatively and quantitatively similar to the inhibition of oxidation of the various substrates. The inhibition of DCIP reductase activities by TTB was qualitatively similar to carboxin, but TTB was a less effective inhibitor with all substrates tested. The inhibition of DCIP reductase by carboxin could be relieved by phenazine methosulfate with all substrates except d-lactate. Only slight inhibition of d-lactate-stimulated uptake of [(14)C]glycine by these membrane vesicles was seen with carboxin. Uptake of [(14)C]glycine could be stimulated to varying degrees with the other substrates tested, but in no case did carboxin cause significant inhibition. Membranes isolated from M. denitrificans are a useful system for investigating the mechanism of inhibition of electron transport function by carboxin, and the use of this system for evaluations of carboxin and its metabolites is suggested.  (+info)

3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. (4/16)

We report three new structures of mitochondrial respiratory Complex II (succinate ubiquinone oxidoreductase, E.C. 1.3.5.1) at up to 2.1 A resolution, with various inhibitors. The structures define the conformation of the bound inhibitors and suggest the residues involved in substrate binding and catalysis at the dicarboxylate site. In particular they support the role of Arg(297) as a general base catalyst accepting a proton in the dehydrogenation of succinate. The dicarboxylate ligand in oxaloacetate-containing crystals appears to be the same as that reported for Shewanella flavocytochrome c treated with fumarate. The plant and fungal toxin 3-nitropropionic acid, an irreversible inactivator of succinate dehydrogenase, forms a covalent adduct with the side chain of Arg(297). The modification eliminates a trypsin cleavage site in the flavoprotein, and tandem mass spectroscopic analysis of the new fragment shows the mass of Arg(297) to be increased by 83 Da and to have the potential of losing 44 Da, consistent with decarboxylation, during fragmentation.  (+info)

Oxathiin carboxanilide, a potent inhibitor of human immunodeficiency virus reproduction. (5/16)

Oxathiin carboxanilide (OC), NSC 615985, a compound originally synthesized as a potential fungicide, was demonstrated to be highly active in preventing human immunodeficiency virus (HIV)-induced cell killing and in inhibiting HIV reproduction. Virus-infected CD4+ lymphocytes were completely protected by 0.5 microM OC, whereas no toxicity was observed at concentrations below 50 microM OC. Production of infectious virus, viral p24 antigen, and virion reverse transcriptase were reduced by OC at concentrations that prevented viral cell killing. A variety of CD4+ T-cell lines were protected by OC from HIV cytopathicity, and OC inhibited two distinct strains of HIV-1. However, HIV-2 infections were unaffected by OC. OC had no direct effect on virions of HIV or on the enzymatic activities of HIV reverse transcriptase or HIV protease. Time-limited treatments of cells with OC before, during, or after exposure of cells to virus failed to protect cells from the eventual cytopathic effects of HIV, and OC failed to inhibit the production of virus from cells in which infection was established or from chronically infected cells. We conclude that the highly active OC has a reversible effect on some early stage of HIV-1 reproduction and cytopathicity. Pilot in vivo experiments showed that circulating concentrations of OC exceeding 1 microM could be achieved and sustained in hamsters for at least a week with no remarkable toxicological sequelae. OC represents a new class of anti-HIV agents that are promising candidates for drug development.  (+info)

Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site. (6/16)

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Five carboxin-resistant mutants exhibited various responses to carboxin and related fungicides. (7/16)

Five carboxin-resistant mutants from Aspergillus oryzae were characterized by the sensitivities of their mycelial growth and succinate dehydrogenase (SDH) activity to carboxin and three related fungicides. Despite a significant resistance to carboxin, exhibited by all the mutants, their patterns of sensitivity to the other fungicides was distinct. This provides clues to the molecular interaction between SDH and these fungicides.  (+info)

Molecular characterization of boscalid resistance in field isolates of Botrytis cinerea from apple. (8/16)

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"Carboxin". PubChem. National Center for Biotechnology Information. Retrieved 2020-12-06. Media related to Anilides at Wikimedia ... Herbicides Fungicides - Oxycarboxin, Carboxin Carl N. Webb (1941). "Benzanilide". Organic Syntheses.; Collective Volume, vol. 1 ...
Carboxin was mainly used to control disease caused by basidiomycetes such as stem rusts and Rhizoctonia diseases. More recently ... Ubiquinone type inhibitors include carboxin and thenoyltrifluoroacetone. Succinate-analogue inhibitors include the synthetic ...
Seed treatments: carboxin, fenpiclonil, tebuconazole, triadimenol, triticonazole. Mathre, D.E. (1997). Compendium of barley ...
Systemic seed treatment fungicides include carboxin, difenoconazole, triadimenol and others and are highly effective. However, ...
Carboxin is a commonly used fungicide on seeds, which works well to prevent onset of disease. In addition to seed treatments, ...
The most common type of systemic fungicides used for loose smut are from the Carboxin group of chemicals. Although carboxins ...
Fungicide seed treatments include: captan, mancozeb, maneb, thiram, pentachloronitrobenzene (PCNB) or carboxin guazatine plus, ...
Chemical control involves using specific pesticides such as benomyl, captafol, captan, carboxin, metalaxyl, propamocarb ...
... padwickii and the particular strains found there are highly resistant to carboxin and moderately resistant to a few other ...
... carboxin MeSH D03.383.533.249 - benzoxazines MeSH D03.383.533.500 - ifosfamide MeSH D03.383.533.640 - morpholines MeSH D03.383. ...
... carboxin MeSH D02.065.199.385 - encainide MeSH D02.065.199.420 - flutamide MeSH D02.065.199.750 - prilocaine MeSH D02.065. ...
... sec-butylamine calcium polysulfide captafol captan carbamate fungicides carbamorph carbanilate fungicides carbendazim carboxin ...
Carboxin fungicide is useful for wheat. Click here to learn more about this Thiram fungicide. ... Carboxin is a group G, oxathiin, systemic fungicide with protective and curative action. It is also a growth regulator that ... It is a broad spectrum systemic(Carboxin 17.5%) and contact (Thiram 17.5%) fungicide for the control of both seed and soilborne ...
Gene replacement with gfp as reporter gene, promoter replacement with crg1 promoter and carboxin resistance cassette ... Gfp as reporter genepMF4-1c with carboxin resistance cassette ... pMF1-c with carboxin resistance cassette * pMF1-hs with ...
... find details about Arochemical Carboxin manufacturers, supplier and wholesaler - LISKON. ... Arochemical Carboxin. LISKON is Arochemical Carboxin manufacturers and suppliers in China who can wholesale Arochemical ... If you interested in Arochemical Carboxin products, please contact with us. Tips: Special needs, for example: OEM, ODM, ... Carboxin. We can provide professional service and better price for you. ...
In this study, we establish a novel strategy for locus-specific integration of exogenous DNA via carboxin-resistance ... Construction of a vector for targeted integration into the Mosdi1 locus in M. oryzae. a The effect of carboxin against mycelial ... In Mosdi1 R left flank, a point mutation, which resulted in an amino-acid substitution (H245L), is made to acquire carboxin ... In this integration, the carboxin-resistant Mosdi1 R allele and cytoplasmic eGFP were simultaneously inserted into the genome ...
Carboxin can induce cardiotoxicity in zebrafish embryos.. Huang Y; Wang Z; Peng Y; Xu R; Yan J; Xiong C; Ma J; Zhong K; Lu H. ...
O tratamento com carboxin + thiram causa fitotoxicidade nos embriões submetidos à secagem. Foi constatada a presença de fungos ... The carboxin + thiram treatment is phytotoxic for dried embryos. "Field" fungi develop according to the degree of embryo ... A sample of embryos from each stage and drying level was treated with carboxin + thiram. Embryos were then stored at 7 or 25 °C ... De cada fase e nível de secagem, uma amostra foi tratada com carboxin + thiram. Embriões de todos os tratamentos foram ...
Carboxin, pirimiphos methyl, permethrins, and carbaryl were detected in both unwashed and washed samples of seed. Carboxin, ... carboxin, -76.6%; pirimiphos methyl, +4.6%; total permethrin, -9.7%; and carbaryl -56.1%. Only carboxin and total permethrin ... Health risks from chronic exposure to carboxin and pirimiphos methyl in these amounts are unclear. The extent of this practice ... carboxin, 244 and 57 p.p.m.; pirimiphos methyl, 8.18 and 8.56 p.p.m.; total permethrin, 3.62 and 3.27 p.p.m.; and carbaryl, ...
Carboxin Preferred Term Term UI T006495. Date01/01/1999. LexicalTag NON. ThesaurusID ... Carboxin. Tree Number(s). D02.065.199.350. D02.092.146.113.350. D03.383.517.200. Unique ID. D002261. RDF Unique Identifier. ... Carboxin Preferred Concept UI. M0003400. Registry Number. 5A8K850HDE. Related Numbers. 5234-68-4. Scope Note. A systemic ...
C 5234-68-4 Carboxin DTXSID0023951 CC1=C(SCCO1)C(=O)NC1=CC=CC=C1 GYSSRZJIHXQEHQ-UHFFFAOYSA-N CC1=C(SCCO1)C(=O)NC1=CC=CC=C1 ...
... ions and carboxin on montmorillonite modified with Rhizobium leguminosarum bv. trifolii exopolysaccharide. J. Hazard. Mater. ...
Carboxin - Preferred Concept UI. M0003400. Scope note. A systemic agricultural fungicide and seed treatment agent. ...
Carboxin D2.92.146.113.350 Carcinoma, Intraductal, Noninfiltrating C4.557.470.200.240.187.250 Carcinoma, Lobular C4.588.180.437 ...
Carboxin Preferred Term Term UI T006495. Date01/01/1999. LexicalTag NON. ThesaurusID ... Carboxin. Tree Number(s). D02.065.199.350. D02.092.146.113.350. D03.383.517.200. Unique ID. D002261. RDF Unique Identifier. ... Carboxin Preferred Concept UI. M0003400. Registry Number. 5A8K850HDE. Related Numbers. 5234-68-4. Scope Note. A systemic ...
Treatment with Carboxin; Thiram® (250 ml) + Imidacloprid® (150 ml) allowed a higher value in the first count of germination in ...
... carboxin,noun,E0300748,yes oxy,oxycellulose,noun,E0208073,cellulose,noun,E0015775,yes oxy,oxychlordane,noun,E0305413,chlordane, ...
... carboxin, E0300757,Bukarban,carbutamide, E0300760,Oranil,Carbutamide, E0300761,Oranyl,carbutamide, E0300775,Nitrumon,carmustine ...
Information Services for agro chemicals Projects
Carboxin. CAS#. :. 5234-68-4. Molecular Weight. :. 235.31. Molecular Formula. :. C12H13NO2S. ...
Seed treatment with Trichoderma (6g/kg) and Vitavax (Carboxin) (1g/kg) *Seed treatment with Rhizobium culture one packet (200 g ...
Hygromycin B, carboxin and nourseothricin susceptibility of polyunsaturated fatty acid producing Mortierella and Umbelopsis ...
The passage introduces the production and hazards of Dimethyl carbonate.
N0000007164 Carboplatin N0000179068 carbopol 940 N0000005780 Carboprost N0000167117 Carboxin N0000168050 Carboxy-Lyases ...
ENHANCED: metalaxyl, fludioxonil, myclobutanil, carboxin, ipconazole, acephate and imidacloprid. PREMIER: metalaxyl, ...
Anchor, which contains the fungicides Thiram and Carboxin, also gave reasonably good control. The commonly used fungicide ...
permethrin + carboxin (Kernel Guard Supreme) at 1.5 oz of formulated product per 42 lb seed (2 oz per 56 lb seed). REI 12 hr. ...
  • It is a broad spectrum systemic(Carboxin 17.5%) and contact (Thiram 17.5%) fungicide for the control of both seed and soilborne diseases. (dhanuka.com)
  • In this study, the relationship between fungi and the conservation of I. vera embryos with different levels of hydration and maturity was studied, together with the efficiency of treating with carboxin + thiram (300 mL / 100 kg of embryos) for fungus control. (scielo.br)
  • A sample of embryos from each stage and drying level was treated with carboxin + thiram. (scielo.br)
  • The carboxin + thiram treatment is phytotoxic for dried embryos. (scielo.br)
  • Neste trabalho objetivou-se analisar o grau de interferência dos fungos na conservação de embriões de I. vera com diferentes níveis de hidratação e de maturidade, bem como a eficiência do carboxin + thiram (300 mL/ 100 kg de embriões) no controle desses fungos. (scielo.br)
  • De cada fase e nível de secagem, uma amostra foi tratada com carboxin + thiram. (scielo.br)
  • O tratamento com carboxin + thiram causa fitotoxicidade nos embriões submetidos à secagem. (scielo.br)
  • Anchor, which contains the fungicides Thiram and Carboxin, also gave reasonably good control. (teagasc.ie)
  • Specific environmental mixtures that were investigated in this thesis included the commercial agricultural product Vitavax 200FF and its active ingredients, carboxin and thiram. (edu.au)
  • It was also demonstrated that degradation of the active ingredients of Vitavax 200FF, carboxin and thiram could occur via abiotic catalytic processes as well as via biotic transformation. (edu.au)
  • Carboxin is a group G, oxathiin, systemic fungicide with protective and curative action. (dhanuka.com)
  • Carboxin, a systemic fungicide against most fungi, is identified to inhibit the respiratory chain by affecting the enzyme activity of succinate dehydrogenase (SDH) (Skinner et al. (springeropen.com)
  • In this study, we establish a novel strategy for locus-specific integration of exogenous DNA via carboxin-resistance reconstitution by a point-mutation (H245L) on succinate dehydrogenase subunit Mosdi1. (springeropen.com)
  • 10. The carboxin-binding site on Paracoccus denitrificans succinate:quinone reductase identified by mutations. (nih.gov)
  • Unwashed and washed seed samples contained, respectively: carboxin, 244 and 57 p.p.m. (nih.gov)