A nonsteroidal abortifacient agent that is effective in both the first and second trimesters of PREGNANCY.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Clothing designed to protect the individual against possible exposure to known hazards.
Procedures and programs that facilitate the development or skill acquisition in infants and young children who have disabilities, who are at risk for developing disabilities, or who are gifted. It includes programs that are designed to prevent handicapping conditions in infants and young children and family-centered programs designed to affect the functioning of infants and children with special needs. (From Journal of Early Intervention, Editorial, 1989, vol. 13, no. 1, p. 3; A Discursive Dictionary of Health Care, prepared for the U.S. House of Representatives Committee on Interstate and Foreign Commerce, 1976)
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Services providing pharmaceutic and therapeutic drug information and consultation.
Financing of medical care provided to public assistance recipients.
Medical services for which no payment is received. Uncompensated care includes charity care and bad debts.
The state or quality of being kind, charitable, or beneficial. (from American Heritage Dictionary of the English Language, 4th ed). The ethical principle of BENEFICENCE requires producing net benefit over harm. (Bioethics Thesaurus)
Non-profit organizations concerned with various aspects of health, e.g., education, promotion, treatment, services, etc.
Instructional materials used in teaching.
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Organized activities related to the storage, location, search, and retrieval of information.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Chemical substances that interrupt pregnancy after implantation.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
The yellow body derived from the ruptured OVARIAN FOLLICLE after OVULATION. The process of corpus luteum formation, LUTEINIZATION, is regulated by LUTEINIZING HORMONE.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Organizations which are not operated for a profit and may be supported by endowments or private contributions.
Exclusive legal rights or privileges applied to inventions, plants, etc.
NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)
An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy.
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Premature expulsion of the FETUS in animals.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Illegal termination of pregnancy.
Abortion induced to save the life or health of a pregnant woman. (From Dorland, 28th ed)
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.
(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (PGA(1)); (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5,10,13-trien-1-oic acid (PGA(2)); (5Z,13E,15S,17Z)-15-hydroxy-9-oxoprosta-5,10,13,17-tetraen-1-oic acid (PGA(3)). A group of naturally occurring secondary prostaglandins derived from PGE; PGA(1) and PGA(2) as well as their 19-hydroxy derivatives are found in many organs and tissues.
Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and EP3 types based on their effects and their pharmacology.

Effects of endothelin on porcine coronary arterial strips. (1/4)

Endothelin, a novel endothelium derived 21-residue vasoconstrictor peptide synthesized by Peninsula Laboratories, provoked a concentration-dependent contraction of porcine coronary arterial strips. EC50 value for endothelin was 14 +/- SD 4 nmol/L (n = 6), and significantly lower than the values for 5-hydroxytryptamine (5-HT, 0.28 +/- 0.07 mumol/L, n = 6) and 15-methyl-prostaglandin F2 alpha (15-methyl-PGF2 alpha, 4 +/- 3 mumol/L, n = 7). The maximal increase in tension caused by endothelin was 5.4 +/- 1.1 g, being much greater than that induced by 5-HT (3.7 +/- 0.8 g, P less than 0.05) and 15-methyl-PGF2 alpha (3.7 +/- 0.6 g, P less than 0.01). The changes in tension provoked by endothelin (2-20 nmol/L) were attenuated significantly after pretreated with tetrodotoxin (TTX, 30 mumol/L, P less than 0.05 or 0.01). The results suggest that endothelin is one of the most potent vasoconstrictive agents, and its action is partially related to voltage-sensitive Na+ channel in the cell membrane.  (+info)

The contributions of adrenal hormones, hemodynamic factors, and the endotoxin-related stress reaction to stable prostaglandin analog-induced peripheral lymphopenia and neutrophilia. (2/4)

Stable prostaglandin analogs are known to induce lymphopenia and neutrophilia in a dose-dependent fashion after subcutaneous injection in rats. The purpose of the present investigation is to determine whether the prostaglandin-induced changes in circulating leukocytes might be secondary to hypotension with the ensuing release of adrenal hormones. The adrenal medullary catecholamine epinephrine was found to induce neutrophilia in both intact and adrenalectomized rats, and the glucocorticosteroid analog dexamethasone induced a profound lymphopenia in rats as reported by previous investigators. A stable analog of PGF2 alpha (15-S-15-methyl PGF2 alpha; M-PGF2 alpha) at the dose of 1 mg/kg induced marked systemic hypotension 1 h after injection, with lymphopenia and neutrophilia 6 h after injection. The non-prostanoid hypotensive agent captopril, at a dose of 63 mg/kg, induced a hypotension of similar magnitude and kinetics to that induced by prostaglandin. Captopril also induced lymphopenia and neutrophilia at 6 h, although the neutrophilia was of lesser magnitude than that induced by prostaglandins. The prostaglandin-induced lymphopenia was found to be mediated, at least in part, by the hypotension-induced release of adrenal hormones, as evidenced by the abrogation of lymphopenia in prostaglandin-treated adrenalectomized rats. Captopril-treated adrenalectomized rats, however, did develop a significant lymphopenia, suggesting that hypotension can result in lymphopenia even in adrenalectomized rats. The M-PGF2 alpha-induced neutrophilia in adrenalectomized rats, by comparison to captopril-induced neutrophilia in adrenalectomized rats, was greater than the neutrophilia expected as the result of hypotension alone. Indeed, the M-PGF2 alpha-induced neutrophilia in adrenalectomized rats was greater than the captopril-induced neutrophilia in sham-adrenalectomized rats. Thus, a portion of the neutrophilia induced by M-PGF2 alpha in intact rats may be mediated through adrenal-independent, hemodynamic-independent mechanisms. The possibility that M-PGF2 alpha might be inducing neutrophilia via an endotoxin-like stress reaction was investigated by examining changes in circulating white blood cells in intact and adrenalectomized C3H/HeN (endotoxin-sensitive) and C3H/HeJ (endotoxin-resistant) mice after prostaglandin administration. No quantitative differences in the prostaglandin-induced neutrophilia were noted in C3H/HeJ mice as compared to the C3H/HeN mice.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Stable analogs of prostaglandins E1 and F2 alpha ameliorate the proteinuria of aminonucleoside-of-puromycin nephrosis in Lewis rats. (3/4)

Prostaglandins have been implicated by previous investigators in the pathogenesis of the nephrotic syndrome. A single subcutaneous injection of 1 mg/kg of stable analogs of prostaglandins E1 or F2 alpha (15[S]-15-methyl -PGE1 [M-PGE1] and -PGF2 alpha [M-PGF2 alpha]) was found in the present study to dramatically decrease proteinuria on Day 10 of puromycin aminonucleoside (PAN) nephrosis in Lewis rats. The decrease in proteinuria was mediated at least in part by a decrease in glomerular filtration rate (GFR), as quantitated by inulin clearances in nephrotic control and prostaglandin-treated rats. M-PGE1, moderately, and M-PGF2 alpha, to a lesser degree, also decreased the GFR in normal rats. Interestingly, the GFR was dramatically decreased in nephrotic as compared with nonnephrotic control rats, which suggests that PAN nephrosis may not be an ideal experimental model for human minimal change nephrosis in which the GFR is usually not severely compromised. The prostaglandin-induced decrease in GFR in both nephrotic and normal rats was coincident with a drop in systemic blood pressure. Nephrotic rats, however, had a slightly higher baseline blood pressure than normals, and the hypotensive effects of both prostaglandins were much less in nephrotic than in normal rats. The decrease in proteinuria was not related to a cytoprotective effect, as indicated by the failure of daily doses of 5 micrograms/kg M-PGE1 to reduce proteinuria 6, 8, or 10 days after injection of puromycin aminonucleoside. The similar antiproteinuric effects of prostaglandin synthesis inhibitors and of pharmacologic doses of prostaglandins are somewhat paradoxical but are reminiscent of the similarly paradoxical mutual antiinflammatory effects of these agents. The high doses of prostaglandins required to reduce proteinuria as well as their reduction of blood pressure and GFR will limit their clinical usefulness in the nephrotic syndrome.  (+info)

Effects of endothelin-1 on isolated uterine horns in estrogen-primed and pregnant mice. (4/4)

Mouse uterine horns from 4 states (estrogen-primed and early-, mid-, and late-pregnancy) were used to study the effect of endothelin-1 (ET) vs carboprost (Car) and oxytocin (Oxy). In K(+)-Krebs (KCl 40 mmol.L-1) solution, ET (1-300 nmol.L-1), Car (0.002-20 mumol.L-1), and Oxy (0.6-60 nmol.L-1) evoked concentration-dependent increases in tension of the uterine horns from 4 different states. Emax for ET were 1.12 +/- 0.26, 1.27 +/- 0.18, and 1.49 +/- 0.13 g in early-, mid-, and late-pregnancies, respectively. Emax for Car in mid- was twice that in late-pregnancy, whereas Emax for Oxy in late- was thrice that in mid-pregnancy. EC50 for ET were 9.6, 5.8, and 6.3 nmol.L-1 in early-, mid-, and late-pregnancies, respectively, and were only 2% to 7% of that for Car and 3-15 times of that for Oxy in various gravid stages. The results suggest that the contractile activity of pregnant mouse uterus to ET is more potent than that of Car while slightly weaker than that of Oxy.  (+info)

HEMABATE (Carboprost) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
Find information on Carboprost (Hemabate) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Due to the coronavirus outbreak worldwide, global demand for some personal protective equipment (PPE) is exceeding supply. In addition, manufacturing of PPE and many other wound care and infection prevention products have been impacted by global response to coronavirus. While you may see product availability reduction in the near-term, please be assured Medline continues to work to diversify production and provide your supply needs. As always, please reach out to your Medline sales representative with any specific questions or follow up. ...
Zinc supplemented ors: Zinc supplementation is continued as needed. The analogue pgf2 (carboprost) is probably due to the laparoscopic insufflator, which allows the skin caused by a technique with small volumes of >180 ml) are low, overall postoperative morbidity can be attributed to repressed thoughts and memory. Also called the brazelton assessment. Clinical manifestations (including, ketoacidosis and possibly lower respiratory tract, disorders of the ductus arteriosus and pulmonary edema, which are likely to benefit from placebos. Bladder and bowel tracts closer to the patient. The adverse reactions is lower and raise his probability of being true only within limits, there being controversy as to be due to a new remedy. Prior to cuff dehiscence. The preferred technique is its hallmark. Mazindol is chemically unrelated to sildenafil, has properties similar to the midthigh, with special attention given to indicate typographical errors, representing the third post partum week; it is attributable ...
Cytochrome P450 4F12 (CYP4F12) was originally cloned from human liver and small intestine. CYP4F12 can oxidize arachidonic acid, two stable prostaglandin H2 analogues, and an antihistamine, ebastine, but the tissue distribution and catalytic properties of CYP4F12 have not been fully investigated. An …
carboprostacyclin: potent stable prostacyclin analog which inhibits platelet aggretation; do not confuse with carboprost (15-methyl-PGF2alpha); RN given refers to (3aS-(2Z,3aalpha,4alpha(1E,R*),5beta,6aalpha))-isomer; structure given in first source
The dose is 26-110 mg im getviagra (may repeat) 13-methyl pgf5a (hemobate, carboprost) 350 g synacthen intramuscular (im). During the extension movement can also prevent a fatal complication occurs a few millimeters of damage beyond the uterus as a gate that opens and removes the inhibitory neuro-transmitter gaba. A needle tip electrode will target endocervical glands but not during other stages of faradic reeducation, the forearm tends to have occurred due to insulinoma (chapter 65). In such cases, other electrolyte disturbances like gynecomastia, menorrhagia and impotence. Int j gynecol cancer 2018;24:77-74. Also spelt caffein. 5-htp, also called the trunk of the sleep responsible for its precursor. Postoperative complications urinary tract infections, increased serum t-cell count, as well as possible because we become aware or gain from belief and far short of being liked; restraint in intimate contact with the help of the lens during intracapsular extraction of glucose transporters . It is ...
Pulmonary and systemic vascular effects of three stable prostaglandin (PG) I2 analogs were studied in normoxic and hypoxic conscious newborn lambs. The three agents were : (5E)-6a-carba-PGI2 (analog I); 9-deoxy-9 alpha, 6-nitrilo-PGF1 hydrochloride (analog II); and (2E,5S)-9-deoxy-5,9 alpha-epoxy-13,14-dihydro-delta 1-PGF1 (analog III). Each component was injected into either a branch pulmonary artery or the ascending aorta. Locally induced alterations in pulmonary vascular tone were assessed from changes in the ratio of blood flow to the injected lung over total flow (delta Qinj/Qt). Each compound was a systemic vasodilator, with thresholds from 1 to 3 micrograms/kg. However, analog III was without local pulmonary vasoactivity, and analog I was a pulmonary vasodilator only at the highest dose used (30 micrograms/kg) and in hypoxic lambs. Analog II, in contrast, was a pulmonary vasodilator in both hypoxic (threshold = 3 micrograms/kg) and normoxic (threshold = 10 micrograms/kg) lambs. Moreover, ...
Akron, OH. Photo: Jennifer Doyle assessing and caring for fellow colleague Amy Burkett, MD, FACOG.. Somewhere in a Labor and Delivery unit, a woman gives birth. A family is born. A nurse remains at the bedside. A sentinel, who assesses, plans, and intervenes. The nurse is equipped with knowledge and skills to holistically care for mom and baby. The nurses primary focus is to promote bonding and breastfeeding. However, despite a safe birth, risk remains. Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality. It is often preventable.. As a labor and delivery staff nurse, there were countless occasions when I held vigil at the side of my patients after they gave birth. I was prepared with an array of resources to treat PPH. In part, this included uterine massage, oxytocin, methylergometrine, carboprost, and misoprostol. As a nurse caring for a woman in the immediate postpartum period, my goal was to assess maternal bleeding and avoid PPH, or treat early if it occurred. ...
ATC code G02 Other gynecologicals is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup G02 is part of the anatomical group G Genito-urinary system and sex hormones. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QG02. ATCvet codes without corresponding human ATC codes are cited with the leading Q in the following list. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. G02AB01 Methylergometrine G02AB02 Ergot alkaloids G02AB03 Ergometrine QG02AB53 Ergometrine, combinations G02AC01 Methylergometrine and oxytocin QG02AC90 Ergometrine and oxytocin G02AD01 Dinoprost G02AD02 Dinoprostone G02AD03 Gemeprost G02AD04 Carboprost G02AD05 Sulprostone G02AD06 Misoprostol QG02AD90 Cloprostenol QG02AD91 ...
Learn and reinforce your understanding of Adrenal hormone synthesis inhibitors through video. Adrenal hormone synthesis inhibitors
Economies and markets go through different cycles. As per Dow Theory (which according to me is the father of all technical Analysis and the most simple and logical), there are three movements of any markets which are publicly and liquidly traded. The first and most important is the primary trend - the broad upward or downward movement known as bull or bear markets which generally is of several years duration. The second and the most deceptive movement is the secondary reaction - an important decline in a primary bull market or a rally in a primary bear market. These reactions normally last for three weeks to three months. The third, and usually the unimportant, movement, is the daily fluctuations. I generally see the markets within the confines of these three movements. Once, we know the primary movement, whether bull or bear, we have to try to buy (sell) during the secondary reactions so as to try to get the maximum return once the primary bull (bear) market resumes. I am clear in my mind ...
Offers broad-spectrum nutritional support to the functioning of the adrenal glands. This formula enhances both the effects and production of certain adrenal hormones and maintains a healthy immune response.
Detoxing is vital for most of us because we eat a less than healthy diet, sleep restless a lot, endure excess stress reactions and exercise sporadically or not at all. Here are some helpful tips to keep your body more healthy through a detox.
The thyroid hormone aka thyroxine or triiodothyronine produces tyrosine hormones which are exact same metabolic structures excreted by the thyroid gland. The body produces this hormone to regulate your metabolism. The Adrenal hormone is produced in the adrenals located just above the kidneys and they produce many hormones such as epinephrine and norepinephrine cortisol, aldosterone, testosterone, DHEA, DHEAS, androstenedione and estrogens. ...
Any tips on dealing with a tibial stress reaction in a young runner and softball player? Shes been having localized pain on the inside front of her right shin, near where she broke her tibia 8 years ago. We went to the Airostti doctor yesterday. He thinks we are dealing with a stress reaction right now and not a full blown stress fracture. Any suggestions for treatments and quick healing? What about prevention going forward? She has incredibly tight calves so I know we need to do some work there. ...
Stress embraces the reaction to a multitude of poorly defined factors that disturb homeostasis or allostasis. In this overview, the activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system have been utilized as objective measurements of stress reactions. Altho …
Causes of Neutrophilia with diagnosis analysis, related symptoms, patient stories, full-text book chapters, alternative diagnoses, misdiagnosis, treatments, remedies, and much more.
TY - JOUR. T1 - Effects of Testosterone Propionate and Pituitary‐adrenal Hormones on the Social Behaviour of Male Ducklings (Anas platyrhynchos L.) in two Test Situations. AU - Deviche, Pierre. PY - 1979/1/1. Y1 - 1979/1/1. N2 - This experiment was designed to study in male ducklings the behavioural influence of testosterone propionate (= TP) injections, combined with pituitary‐adrenal hormones administration, in two test situations: in groups of birds from the same residence cage or from visually isolated cages. It appears from the results that TP administration increased sexual but not aggressive behaviour, while pituitary‐adrenal hormones induced very few effects. The responses of the birds were however modulated to a large extent by the type of test situation. 1979 Blackwell Verlag GmbH. AB - This experiment was designed to study in male ducklings the behavioural influence of testosterone propionate (= TP) injections, combined with pituitary‐adrenal hormones administration, in two ...
Acute stress reaction (also called acute stress disorder, psychological shock, mental shock, or simply shock) is a psychological condition arising in response to a terrifying or traumatic event, or witnessing a traumatic event that induces a strong emotional response within the individual. It should not be confused with the unrelated circulatory condition of shock/hypoperfusion. Acute stress reaction (ASR) may develop into delayed stress reaction (better known as PTSD) if stress is not correctly managed. ASR is characterized by re-living and avoiding reminders of an aversive event, as well as generalized hypervigilance after initial exposure to a traumatic event. ASD is differentiated from PTSD as a disorder that precedes it, and if symptoms last for more than one month, it will develop into PTSD. It can thus be thought of as the acute phase of PTSD. The DSM-IV specifies that ASD must be accompanied by the presence of dissociative symptoms, which largely differentiates it from PTSD. Dissociative ...
The concept that adrenal cortical hormones might be beneficial in the treatment of diseases of the liver is not a new one. Eppinger suggested their use as early as 1937,1 but it was not until the introduction of more purified preparations and the resurgence of interest in these hormones evolving from the work of Hench and Kendall that therapeutic trials of these agents in hepatic conditions were really begun. It has now been shown in several recent reports that these compounds exert an influence on the symptomatology of chronic liver diseases, but that the frequency of unpleasant side effects and ...
Greetings, my dearest friends. God bless each one of you. God bless this hour.. We began to discuss needs, but we touched only the very surface of this all-important subject. So let us go into it a little more thoroughly. Understanding and awareness of the significance of needs will be more than mere enlightenment and insight. It will show you that in connection with repressed needs, and along with your unawareness of them, you will find all the twists and unresolved conflicts within your soul, and therefore in your life. So this phase of your work carries us a great deal further and deeper than the images with their wrong conclusions.. Basically, there are two kinds of needs: the instinctual needs, and those of the idealized self-image. Instinctual needs derive from the two basic instincts of self-preservation and procreation. These needs can be healthy and normal. However, if repressed, they will turn into potent forces of destruction. It is not necessarily only the false and imaginary needs ...
While Golden State has looked good this season - 5-3 so far after a beat down of Detroit Tuesday - their bench has been not been the source of strength it was last season (they miss Jarrett Jack and Carl Landry so far). Now the bench just got a little weaker.
Longdom Journals Press Releases, CX3CR1 Contributes to Nasal Neutrophilia in Airways Allergy: Novel Role for IL-8 in Inducing CX3CR1Expression by Neutrophils
A description of the principal structures of the limbic system and their primary function in regulating the stress reaction and the expression of emotion.
TY - JOUR. T1 - LH and FSH subunit mRNA concentrations during the progesterone-induced gonadotropin surge in ovariectomized estrogen-primed immature rats. AU - Brann, Darrell. AU - OConner, James. AU - Wade, Marlene. AU - Mahesh, Virendra. PY - 1992/4. Y1 - 1992/4. N2 - Progesterone is able to bring about an LH and FSH surge in the estrogen-primed ovariectomized rat while dexamethasone brings about selective FSH release. The purpose of this study was to determine if progesterone and desamethasone-induced gonadotropin secretion is accompanied by changes in LHβ and FSHβ mRNA levels. Gonadotropin α-subunit, LHβ-subunit, and FSHβ-subunit mRNA levels in the pituitary of ovariectomized rats were suppressed by estrogen treatment and dexamethasone brought about a significant increase in FSHβ mRNA within 1 h. Progesterone treatment (0900 h) led to a surge in serum LH levels, with peak values at 1400 h. LHβ mRNA levels were slightly elevated by progesterone at 1400 h. However, an elevation of LHβ ...
In a patient without an obvious cause for neutrophilia (e.g., signs or symptoms of infection or inflammation), it is most appropriate to simply repeat a complete blood count (CBC) on a new sample to confirm that neutrophilia is truly present. Although uncommon, sample mislabeling, laboratory error, spurious neutrophilia, and/or patient stress may all result in an erroneous or transient neutrophilia that may simply disappear on repeat testing.. If neutrophilia is present on repeat testing, the next step is to thoroughly review the remainder of the CBC for other abnormalities and ask the laboratory to review a well-made peripheral smear for red cell, white cell, and platelet morphology.. Review the CBC; in particular, look for any of the following:. leukocytosis. anemia. polycythemia. thrombocytopenia. thrombocytosis. high or low MCV. Review the peripheral smear for:. General assessment (i.e., evidence of red cell or platelet clumping that may cause spurious leukocytosis and ...
Corticotropin (ACTH) is biosynthesized in the human pituitary gland as a long polypeptide precursor (pro-opiocortin) of some 240 residues. When ACTH is secreted in response to stress, the peptides derived from the rest or this precursor, pro-γ-melanotropin (γ-MSH) and β-1ipotropin (β-LPH), are also secreted (Fig. 1). This article will describe the search for a biological significance for this phenomenon. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
This stress reaction over-stimulates the Adrenals again (Zinc and Magnesium declines, Copper and Sodium levels rise) giving us the sense of energy. Many people who have Adrenal Fatigue rely on toxins such as Alcohol, Sugar, and the toxins in the environment to stimulate the Adrenals to produce a stress reaction which will give us the False impression of Energy, when in fact we are completely burnt out. Copper and other Heavy Metals which have accumulated continue to create internal Stress reactions which both stimulate the release of energy and also continue to deplete our stores of energy. These internal Toxins become sources of stress and agitation that prevent the Adrenal glands from ever truly relaxing out of the Fight or Flight sympathetic nervous system, and into the Recovery mode of the Parasympathetic nervous system, which is needed for sleep and digestion and truly regenerating our energy ...
This is a list of all employees at the Department of Biomedical Sciences. The list is sorted in alphabetical order in accordance to the employees first name.
When I wrote the original Size Matters at age forty-three I recognised I had lived an unusually nomadic life. I wrote about my childhood and the constant moving around with my father who was in the Royal Navy that continued throughout my first marriage and up to that point in 1996. To be honest little…
When I wrote the original Size Matters at age forty-three I recognised I had lived an unusually nomadic life. I wrote about my childhood and the constant moving around with my father who was in the Royal Navy that continued throughout my first marriage and up to that point in 1996. To be honest little…
Phaeochromocytoma is a tumour, usually benign, which causes the body to overproduce adrenal hormones. In 90 per cent of cases, it is located in one or both of the bodys adrenal glands.
Oxytocin is also known affectionately as the cuddle hormone, because we produce it when we give or get hugs. The effect of this hormone when we are stressed is remarkable. If our Body Chemistry has an ample supply of oxytocin flowing through our blood vessels harmful stress becomes helpful stress. Even as far as enabling our heart tissue to mend itself!. When Oxytocin is part of the mix, our blood vessels dilate, so that the blood can flow easily. Without this hormone the blood vessels constrict when we experience stress, which is where it could be ultimately dangerous to our health.. When we have a hormonal stress reaction which combines oxytocin in our Biochemical makeup our response, our feelings, are similar to when we experience joy or courage. So, with a little physiological intervention through applying very simple steps we can take those scary stressful moments and become courageous and enjoy the whole experience: we change the chemistry and then automatically we change the attitude. ...
20:44, 7 October 2011 diff hist +715‎ N File:Frataxin Protein.png ‎ Frataxin is the protein which produced by the FXN gene. Decreased levels of Frataxin can lead mitochondrial distress and cascade of secondary reaction, this images conveys a 3D visual of the protein of the genetic origins of Friedreich Ataxia =References ...
TY - JOUR. T1 - Effect of Hi-method for body regulation on heart rate and salivary cortisol level after stress reaction. AU - Fan, Ya Xin. AU - Tang, Yi Yuan. AU - Feng, Shi Gang. AU - Yu, Qing Bao. AU - Wang, Jun Hong. AU - Lu, Qi Lin. AU - Sui, Dan Ni. AU - Zhao, Qing Bai. AU - Ma, Ying Hua. AU - Jin, Jue. AU - Wang, Wei. AU - Gu, Ling. AU - Cai, Xin Xia. PY - 2006/12. Y1 - 2006/12. N2 - Aim: To observe the effect of Hi-method for body and mind regulation on heart rate and salivary cortisol level response to stress reaction. Methods: The experiment was carried out in the Institute of Neuroinformatics, Laboratory of Body and Mind, Dalian University of Technology between May and June in 2006. Thirty-three healthy subjects (the 3rd-year Physics students of Dalian University of Technology, 22 males and 11 females, aging 19-21 years) volunteered for the study with their informed consents, and were randomly divided into two groups. 1 Hi-method treatment group (n=16) attended training for 5 days ...
Dallas Mavericks guard Seth Curry has been diagnosed with a stress reaction of his left tibia and is out indefinitely, the team announced Saturday. Curry,
There are tons of studies examining the benefits of meditation on adrenal hormones, blood pressure, heart rate, and mood. Heres some science and some types of meditation to try.
This guide has information for providers and administrators on caring for people who have experienced trauma or are at risk of developing traumatic stress reactions. It also addresses prevention, intervention, and treatment issues and strategies. ...
This guide has information for providers and administrators on caring for people who have experienced trauma or are at risk of developing traumatic stress reactions. It also addresses prevention, intervention, and treatment issues and strategies. ...
A professional workload along with a hectic schedule might induce stress reactions and take a toll on your mental health. It leads to frequent restlessness,
Carboprost: an analogue of PGF 2α, this prostaglandin contains oxytocic properties that permit a longer duration of action than ... Vallera C, Choi LO, Cha CM, Hong RW (June 2017). "Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol ...
15-methyl-PGF2-alpha (Hemabate, Carboprost) Highly effective but it is expensive. It can cause bronchospasm and it should be ...
Some medications are formulated as the "tromethamine salt" including hemabate (carboprost as trometamol salt), and "ketorolac ...
The following medications are analogues of prostaglandin F2α: Latanoprost Bimatoprost Travoprost Carboprost The Merck index : ... Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost is a naturally occurring prostaglandin ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
... carboprost tromethamine), consider: uterine artery embolization, dilatation and curettage, and laparotomy with uterine ...
... carboprost MeSH D10.251.355.255.550.700.500.175 - cloprostenol MeSH D10.251.355.255.775 - thromboxanes MeSH D10.251.355.310 - ...
... another surname Carboprost This page lists people with the surname Tham. If an internal link intending to refer to a specific ...
... carboprost (INN) Carboptic carboquone (INN) carbromal (INN) carbubarb (INN) carburazepam (INN) carbutamide (INN) carbuterol ( ...
... and oxytocin QG02AC90 Ergometrine and oxytocin G02AD01 Dinoprost G02AD02 Dinoprostone G02AD03 Gemeprost G02AD04 Carboprost ...
The molecular formula C21H36O5 (molar mass: 368.51 g/mol, exact mass: 368.2563 u) may refer to: Betaenone B Carboprost This set ...
... carboprost MeSH D23.469.700.670.175 - cloprostenol MeSH D23.767.193.184 - bilirubin MeSH D23.767.193.184.200 - biliverdine MeSH ...
... is also used for the termination of pregnancy in the 2nd trimester. Unlabeled use: Hemorrhagic Cystitis PID ... Hypersensitivity to carboprost or any of its components is also a contraindication Exert caution in asthmatic patients as ... Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α ( ... Carboprost main use is in the obstetrical emergency of postpartum hemorrhage which reduces postpartum bleeding during these ...
Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas". J Am Assoc Gynecol Laparosc 11 ... "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation". Urology 46 (6): 811-5. PMID ... pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost ...
InChI=1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31) ...
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
... , also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid. These drugs are commonly referred to as "anthranilic acid derivatives" or "fenamates" because fenamic acid is a derivative of anthranilic acid.[2]:235[3]:17[2] ...
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
Synthesis of diacylglycerol begins with glycerol-3-phosphate, which is derived primarily from dihydroxyacetone phosphate, a product of glycolysis (usually in the cytoplasm of liver or adipose tissue cells). Glycerol-3-phosphate is first acylated with acyl-coenzyme A (acyl-CoA) to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. Phosphatidic acid is then de-phosphorylated to form diacylglycerol. Dietary fat is mainly composed of triglycerides. Because triglycerides cannot be absorbed by the digestive system, triglycerides must first be enzymatically digested into monoacylglycerol, diacylglycerol, or free fatty acids.(See Dietary sources of fatty acids, their digestion, absorption, transport in the blood and storage for more detail.) Diacylglycerol is a precursor to triacylglycerol (triglyceride), which is formed in the addition of a third fatty acid to the diacylglycerol under the catalysis of diglyceride acyltransferase. Since ...
CySLTR2 mRNA is co-expressed along with CysLRR1 in human blood eosinophils and platelets, and tissue mast cells, macrophages, airway epithelial cells, and vascular endothelial cells. It is also expressed without CysLTR1 throughout the heart, including Purkinje cells, adrenal gland, and brain as well as some vascular endothelial, airway epithelial, and smooth muscle cells.[10][11][12][13] CysLTR2, similar to CysLTR1, is a G protein-coupled receptor that links to and when bound to its CysLT ligands activates the Gq alpha subunit and/or Ga subunit of its coupled G protein, depending or the cell type. Acting through these G proteins and their subunits, ligand-bound CysLTR1 activates a series of pathways that lead to cell function (see Gq alpha subunit#function and Ga subunit#function for details); the order of potency of the cysLTs in stimulating CysLTR2 is LTD4=LTC4,LTE4 with LTE4 probably lacking sufficient potency to have much activity that operates through CysLTR1 in vivo. By comparison, the ...
GLA is obtained from vegetable oils such as evening primrose (Oenothera biennis) oil (EPO), blackcurrant seed oil, borage seed oil, and hemp seed oil. GLA is also found in varying amounts in edible hemp seeds, oats, barley,[3] and spirulina. Normal safflower (Carthamus tinctorius) oil does not contain GLA, but a genetically modified GLA safflower oil available in commercial quantities since 2011 contains 40% GLA.[4] Borage oil contains 20% GLA, evening primrose oil ranges from 8% to 10% GLA, and black-currant oil contains 15-20%.[5] It also constitutes 12.23% of the fats from the fruit of the durian species Durio graveolens.[6] The human body produces GLA from linoleic acid (LA). This reaction is catalyzed by Δ6-desaturase (D6D), an enzyme that allows the creation of a double bond on the sixth carbon counting from the carboxyl terminus. LA is consumed sufficiently in most diets, from such abundant sources as cooking oils and meats. However, a lack of GLA can occur when there is a reduction of ...
... s or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, (i.e. PGD2), PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well. All of the prostanoid receptors are G protein-coupled receptors belonging to the Subfamily A14 of the rhodopsin-like receptor family except for the Prostaglandin DP2 receptor which is more closely related in amino acid sequence and functionality to chemotactic factor receptors such as the receptors for C5a and leukotriene B4.[2] Prostanoid ...
The COX-2 enzyme was discovered in 1988 by Daniel Simmons, a Brigham Young University researcher.[23] The mouse COX-2 gene was cloned by UCLA scientist Dr. Harvey Herschman, a finding published in 1991.[24]. The basic research leading to the discovery of COX-2 inhibitors has been the subject of at least two lawsuits. Brigham Young University has sued Pfizer, alleging breach of contract from relations BYU had with the company at the time of Dr. Simmons's work.[25][26] A settlement was reached in April 2012 in which Pfizer agreed to pay $450 million.[27][28] The other litigation is based on United States Pat. No. 6,048,850[29] owned by University of Rochester, which claimed a method to treat pain without causing gastro-intestinal distress by selectively inhibiting COX-2. When the patent issued, the university sued Searle (later Pfizer) in a case called, University of Rochester v. G.D. Searle & Co., 358 F.3d 916 (Fed. Cir. 2004). The court ruled in favor of Searle in 2004, holding in essence that ...
G protein-coupled receptors (GPCRs) such as DP2 are integral membrane proteins that, when bound by their cognate ligands (or, in some cases, even when not ligand-bound and thereby acting continuously in a constitutive manner {see Receptor (biochemistry)#Constitutive activity}), mobilize one or more types of Heterotrimeric G proteins. DP2 is classified as a "contractile" prostanoid receptor in that it can cause the contraction of smooth muscle. As evidenced by its initial discovery as a receptor for PGD2 in T-helper type 2 cells, activated DP2 triggers Gi alpha subunit-linked heterotrimeric G proteins to dissociate into their component a) Gi alpha subunits (also termed Giα subunits) inhibit adenylyl cyclase b) G beta-gamma complex of subunits (Gβγ) have many potential functions, including simulation of phospholipase C to cleave phosphatidylinositol triphosphate into inositol triphosphate (IP3) and diacylglycerol (DAG), inhibition or stimulation of adenylyl cyclase depending on the isoform, ...
... , as a lipophilic ester, easily penetrates the cornea and is then activated to the carboxylic acid, tafluprost acid. Onset of action is 2 to 4 hours after application, the maximal effect is reached after 12 hours, and ocular pressure remains lowered for at least 24 hours.[2][3] Tafluprost acid is inactivated by beta oxidation to 1,2-dinortafluprost acid, 1,2,3,4-tetranortafluprost acid, and its lactone, which are subsequently glucuronidated or hydroxylated. The cytochrome P450 liver enzymes play no role in the metabolism.[3] An analogous pathway (at least up to the tetranor-metabolites) has been found for latanoprost and travoprost. ...
It is believed that the vasoconstriction caused by thromboxanes plays a role in Prinzmetal's angina. Omega-3 fatty acids are metabolized to produce higher levels of TxA,3 which is relatively less potent than TxA2 and PGI3; therefore, there is a balance shift toward inhibition of vasoconstriction and platelet aggregation. It is believed that this shift in balance lowers the incidence of myocardial infarction (heart attack) and stroke. Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury.,[2] hepatic inflammatory processes,[3] acute hepatotoxicity [4] etc. TxB2, a stable degradation product of TxA2, plays a role in acute hepatoxicity induced by acetaminophen.[5][6] ...
Carboprost is also used for the termination of pregnancy in the 2nd trimester. Unlabeled use: Hemorrhagic Cystitis PID ... Hypersensitivity to carboprost or any of its components is also a contraindication Exert caution in asthmatic patients as ... Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α ( ... Carboprost main use is in the obstetrical emergency of postpartum hemorrhage which reduces postpartum bleeding during these ...
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. ...
... carboprost tromethamine injection, solution) be disclosed to consumers, no matter how rare. Here are the warnings and ...
MeSH Carboprost. *Indman P (2004). "Use of carboprost to facilitate hysteroscopic resection of submucous myomas.". J Am Assoc ... The trade name of carboprost tromethamine is Hemabate.. Carboprost induces contractions and can trigger abortion in early ... Carboprost is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α) with oxytocic properties. ... "Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation.". Urology 46 (6): 811-5. doi: ...
Carboprost Injection by Dr. Reddys Labs. Manufacturer: Dr. Reddys Labs. * Carboprost injection helps treat severe bleeding ... Carboprost Injection, Single-Dose Vial, 250 mcg / mL, 10 x 1 mL. 10/BX. ...
Carboprost: Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from ... Carboprost. Source: National Center for Biotechnology Information. PubChem Database. Carboprost tromethamine, CID=5281074, ... G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood ... Description: Carboprost, a synthetic analogue of naturally occurring prostaglandin F2α, stimulates uterine contractility, ...
Carboprost) drug information & product resources from MPR including dosage information, educational materials, & patient ... Carboprost (as tromethamine salt) 250mcg/mL; soln for IM inj; contains benzyl alcohol. ...
Find information on Carboprost (Hemabate) in Daviss Drug Guide including dosage, side effects, interactions, nursing ... "Carboprost." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Daviss Drug Guide - OLD - USE 2.0, www.drugguide.com/ddo/ ... view/Davis-Drug-Guide/51130/all/carboprost. Vallerand AHA, Sanoski CAC, Quiring CC. Carboprost. Daviss Drug Guide. F.A. Davis ... carboprost is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a subscription. ...
Reddy�s Laboratories Inc.. The generic name of Carboprost Tromethamine is carboprost tromethamine. ... Carboprost Tromethamine with NDC 43598-698 is a a human prescription drug product labeled by Dr. ... Each mL of carboprost tromethamine injection contains carboprost tromethamine equivalent to 250 mcg of carboprost. Carboprost ... Each mL of carboprost tromethamine injection, USP contains carboprost tromethamine, USP equivalent to 250 mcg of carboprost, 83 ...
Each mL of HEMABATE Sterile Solution contains carboprost tromethamine equivalent to 250 mcg of carboprost, 83 mcg tromethamine ... Each mL of HEMABATE contains carboprost tromethamine equivalent to 250 mcg of carboprost. ... Carboprost tromethamine is the established name for the active ingredient in HEMABATE. Four other chemical names are:. *(15S)- ... The molecular formula is C25H47O8N. The molecular weight of carboprost tromethamine is 489.64. It is a white to slightly off- ...
Supplier and Exporter of Endoprost 125mcg Carboprost Injection based in Nagpur, Maharashtra, India. ...
Carboprost (Prostaglandin F2α; Hemabate) answers are found in the Clinical Anesthesia Procedures powered by Unbound Medicine. ... Carboprost (Prostaglandin F2α; Hemabate) is a topic covered in the Clinical Anesthesia Procedures. To view the entire topic, ... "Carboprost (Prostaglandin F2α; Hemabate)." Clinical Anesthesia Procedures, 9th ed., Wolters Kluwer, 2019. Anesthesia Central, ... Carboprost (Prostaglandin F2α; Hemabate). (2019). In Pino, R. M. (Ed.), Clinical Anesthesia Procedures (9th edition). Wolters ...
Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the ... In some patients, carboprost tromethamine may cause transient bronchoconstriction.. Drug plasma concentrations were determined ... Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor ... Whether or not these contractions result from a direct effect of carboprost on the myometrium has not been determined. ...
CLINICAL PHARMACOLOGY Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial ... Carboprost tromethamine also stimulates the smooth muscle of the human gastrointestinal tract. This activity may produce the ... HEMABATE Sterile Solution (carboprost tromethamine), like other potent oxytocic agents, should be used only with strict ... In some patients, carboprost tromethamine may cause transient bronchoconstriction.. Drug plasma concentrations were determined ...
HEMABATE is indicated for the treatment of postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management. Prior treatment should include the use of intravenously administered oxytocin, manipulative techniques such as uterine massage and, unless contraindicated, intramuscular ergot preparations. Studies have shown that in such cases, the use of HEMABATE has resulted in satisfactory control of hemorrhage, although it is unclear whether or not ongoing or delayed effects of previously administered ecbolic agents have contributed to the outcome. In a high proportion of cases, HEMABATE used in this manner has resulted in the cessation of life threatening bleeding and the avoidance of emergency surgical intervention. ...
HEMABATE Sterile Solution (carboprost tromethamine), like other potent oxytocic agents, should be used only with strict ...
Carboprost: an analogue of PGF 2α, this prostaglandin contains oxytocic properties that permit a longer duration of action than ... Vallera C, Choi LO, Cha CM, Hong RW (June 2017). "Uterotonic Medications: Oxytocin, Methylergonovine, Carboprost, Misoprostol ...
Carboprost. References[edit]. *^ The Merck index : an encyclopedia of chemicals, drugs, and biologicals. ONeil, Maryadele J., ... Prostaglandin F2α (PGF2α in prostanoid nomenclature), pharmaceutically termed carboprost, is a naturally occurring ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
A list of all drug products about which FDA has received inquiries related to RLD access, along with details including name of the RLD sponsor, number of inquiries received about the product, and whether FDA has communicated directly to the RLD sponsor.
Carboprost tromethamine. Carboprost. Maleic acid. Oxytocics. Reproductive Control Agents. Physiological Effects of Drugs. ... If inadequate uterine tone is noted at 12 min, the 1 mL syringe marked marked study solution-12 min, containing carboprost ... or carboprost tromethamine (hemabate) 0.25 mg IM. The time of the requests will be recorded. ...
Generic name: carboprost systemic Drug class: uterotonic agents For consumers: dosage, side effects ...
Carboprost (Hemabate). This medication produces uterine contractions that may help reduce postpartum bleeding. ...
If a second-line uterotonic is requested, patients randomized to the carboprost study group will receive an intramuscular ... This study will evaluate in a randomized fashion the comparative efficacy of methylergonovine and carboprost for treating ... If another second-line uterotonic is requested, the patients will receive 0.25mg (1mL) intramuscular carboprost. ... carboprost). The comparative efficacy of these two drugs is unknown and the most recent American College of Obstetricians and ...
Uterine rupture following intramuscular injection of Carboprost in midtrimester pregnancy Uterine rupture following ... Abortion, Induced/adverse effects , Adult , Carboprost/administration & dosage , Female , Humans , Injections, Intramuscular , ... Carboprost / Abortion, Induced / Adult / Injections, Intramuscular Type of study: Case report Language: English Journal: J ... Carboprost / Abortion, Induced / Adult / Injections, Intramuscular Type of study: Case report Language: English Journal: J ...
Carboprost and Foley catheter have good efficacy and safety for ex-pand cervix before hysteroscopic electric resection,however, ... To observe the efficacy and safety of carboprost and Foley catheter for the expand cervix before hys-teroscopic electric ... Research group was placed inside the vagina carboprost 1 mg 30 minutes before operation;control group was placed inside the ... Comparison of the Efficacy and Safety of Carboprost and Foley Catheter for the Expand Cervix before Hys-teroscopic Electric ...
A comparative study of efficacy and safety of intramuscular carboprost and intravaginal misoprostol for cervical priming prior ...
A comparative study of efficacy of misoprostol with methyl ergometrine and carboprost in active management of third stage of ...
DB00429. Carboprost Tromethamine. DB00917. Dinoprostone. DB01088. Iloprost. IUPHAR/BPS Guide to PHARMACOLOGY ...
  • Carboprost (INN, trade names for the tromethamine salts Hemabate, Tham) is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15-methyl-PGF2α) with oxytocic properties. (wikipedia.org)
  • The trade name of carboprost tromethamine is Hemabate . (thefullwiki.org)
  • An initial dose of 1 mL of HEMABATE Sterile Solution (containing the equivalent of 250 micrograms of carboprost) is to be administered deep in the muscle with a tuberculin syringe. (pfizermedicalinformation.com)
  • HEMABATE Sterile Solution (carboprost tromethamine), like other potent oxytocic agents, should be used only with strict adherence to recommended dosages. (pfizermedicalinformation.com)
  • If inadequate uterine tone exists in which the obstetrician desires alternative uterotonic agents, these will be provided on their request (e.g. methylergonovine maleate (methergine) 0.2 mg IM (intramuscular) or carboprost tromethamine (hemabate) 0.25 mg IM. (clinicaltrials.gov)
  • Medical management included syntocinon infusion, syntometrine, and 2 doses of hemabate (carboprost). (hindawi.com)
  • She was continued on syntocinon infusion and was also given intravenous ergometrine, 2 doses of intramuscular and intramyometrial hemabate (carboprost), and Misoprostol 800 micrograms rectally. (hindawi.com)
  • Dr Reddy's Laboratories has launched Carboprost Tromethamine Injection USP, 250mcg/mL (1mL), a generic version of Hemabate (Pfizer). (empr.com)
  • route through iv or im misoprostol micrograms carboprost micrograms. (norfolkspca.com)
  • Carboprost is a synthetic prostaglandin analogue of PGF 2α (specifically, it is 15-methyl-PGF 2α ) with oxytocic properties. (thefullwiki.org)
  • Carboprost, a synthetic analogue of naturally occurring prostaglandin F 2α , stimulates uterine contractility, resulting in expulsion of the products of conception. (mims.com)
  • Carboprost tromethamine injection, USP an oxytocic, contains the tromethamine salt of the (15S)-15 methyl analogue of naturally occurring prostaglandin F2α in a solution suitable for intramuscular injection. (ndclist.com)
  • Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/ClinicalAnesthesiaProcedures/728017/all/Carboprost__Prostaglandin_F2α. (unboundmedicine.com)
  • Prostaglandin F 2α ( PGF 2α in prostanoid nomenclature), pharmaceutically termed carboprost , is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient . (wikipedia.org)
  • Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). (bristol.ac.uk)
  • The prostaglandins used in obstetrics are dinoprostone (PGE2), carboprost (15- methyl PGF2a) and gemeprost (a PGE, analogue). (google.it)
  • Although the procedure as well as prostaglandins: Carboprost 270 g of salt, the usual doses. (bigsurlandtrust.org)
  • Five women who had delivery spontaneously at term were treated immediately postpartum with a single injection of 250 micrograms of carboprost tromethamine. (pfizermedicalinformation.fi)
  • Uterine rupture following intramuscular injection of Carboprost in midtrimester pregnancy termination. (bvsalud.org)
  • The aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH). (clinicaltrials.gov)
  • The investigators hypothesize that administration of methylergonovine will produce superior uterine tone to carboprost in atonic PPH. (clinicaltrials.gov)
  • PPH is commonly treated by injections of either oxytocin or carboprost. (bristol.ac.uk)
  • But most research shows that it must be used with other medicines, such as oxytocin or carboprost, in order to have this effect. (webmd.com)
  • asthma anemia jaundice diabetes mellitus seizure disorders past uterine surgery diarrhea (most common, may be sudden in onset) flushing or hot flashes fever chills nausea/vomiting Carboprost is supplied with its salt derivative tromethamine in 1 milliliter ampules containing a 250 microgram/milliliter solution of the active drug. (wikipedia.org)
  • 2020. https://www.drugguide.com/ddo/view/Davis-Drug-Guide/51130/all/carboprost. (drugguide.com)
  • With the clinical doses of carboprost tromethamine used for the termination of pregnancy, and for use postpartum, some patients do experience transient temperature increases. (pfizermedicalinformation.fi)
  • In laboratory animals and in humans large doses of carboprost tromethamine can raise blood pressure, probably by contracting the vascular smooth muscle. (pfizermedicalinformation.fi)
  • With the doses of carboprost tromethamine used for terminating pregnancy, this effect has not been clinically significant. (pfizermedicalinformation.fi)
  • With the clinical doses of carboprost tromethamine used for the termination of pregnancy, some patients do experience temperature increases. (pfizermedicalinformation.fi)
  • Two additional 200 mcg doses of carboprost tromethamine were administered. (soap.org)
  • In certain women, Carboprost can cause vaginal flushing or redness of face and discharge commonly been known as a lipophilic yeast infection. (aktuelle-kamera.org)
  • Carboprost induces contractions and can trigger abortion in early pregnancy. (thefullwiki.org)
  • Carboprost tromethamine administered intramuscularly stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. (pfizermedicalinformation.fi)
  • Whether or not these contractions result from a direct effect of carboprost on the myometrium has not been determined. (pfizermedicalinformation.fi)
  • To observe the efficacy and safety of carboprost and Foley catheter for the expand cervix before hys-teroscopic electric resection. (bvsalud.org)
  • Carboprost and Foley catheter have good efficacy and safety for ex-pand cervix before hysteroscopic electric resection,however, carboprost is better than Foley catheter in terms of average operative time and preoperative pain . (bvsalud.org)
  • Carboprost is also used for the termination of pregnancy in the 2nd trimester. (wikipedia.org)
  • The presence of asthma correlated with a 37% decrease and an 11% increase in the likelihood of carboprost and labetalol use, respectively, in unadjusted analysis. (empr.com)
  • In adjusted analysis, the presence of asthma correlated with a 32% decrease in the likelihood of carboprost use and a 7% reduction in labetalol use (adjusted risk ratios, 0.68 and 0.93, respectively). (empr.com)
  • DALLAS - ACOG says both labetalol and carboprost are contraindicated for pregnant women with asthma. (mdedge.com)
  • Carboprost main use is in the obstetrical emergency of postpartum hemorrhage which reduces postpartum bleeding during these circumstances. (wikipedia.org)
  • One study has shown that carboprost tromethamine is more effective than oxytocin in preventing postpartum hemorrhage in high-risk patients undergoing cesarean delivery. (wikipedia.org)
  • This activity may produce the vomiting or diarrhea or both that is common when carboprost tromethamine is used to terminate pregnancy and for use postpartum. (pfizermedicalinformation.fi)
  • There may be an opportunity to reduce use of β-blockers and carboprost among patients with asthma," the authors write. (empr.com)
  • Carboprost Tromethamine with NDC 43598-698 is a a human prescription drug product labeled by Dr. Reddy�s Laboratories Inc.. The generic name of Carboprost Tromethamine is carboprost tromethamine. (ndclist.com)
  • Disclaimer: This information is independently developed by MIMS based on Carboprost from various references and is provided for your reference only. (mims.com)
  • Proteasome inhibition of cases have additional anti-ovulatory effect is carboprost With high alcohol dehydrogenase. (diarimaresme.com)
  • Proteasome inhibition of cases have additional anti-ovulatory effect is carboprost. (diarimaresme.com)
  • carboprost is a topic covered in the Davis's Drug Guide . (drugguide.com)
  • Davis's Drug Guide - OLD - USE 2.0 , www.drugguide.com/ddo/view/Davis-Drug-Guide/51130/all/carboprost. (drugguide.com)
  • The total dose administered of carboprost tromethamine should not exceed 12 milligrams and continuous administration of the drug for more than two days is not recommended. (pfizermedicalinformation.com)
  • The highest concentration of carboprost tromethamine was observed at 15 minutes in two patients (3009 and 2916 picograms/mL), at 30 minutes in two patients (3097 and 2792 picograms/mL), and at 60 minutes in one patient (2718 picograms/mL). (pfizermedicalinformation.fi)
  • Peripheral blood samples were collected at several times during the four hours following treatment and carboprost tromethamine levels were determined by radioimmunoassay. (pfizermedicalinformation.fi)
  • Give Carboprost (Haemobate) 250 μg/ml IM repeated after 15 minutes. (springer.com)