Carbonic Anhydrase V
Carbonic Anhydrases
Carbonic Anhydrase Inhibitors
Carbonic Anhydrase II
Carbonic Anhydrase III
Carbonic Anhydrase I
Acetazolamide
Ethoxzolamide
Benzolamide
Methazolamide
Oligodendroglioma
Brain Neoplasms
Oncogenes
Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. (1/5)
(+info)Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. (2/5)
(+info)Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer. (3/5)
(+info)Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. (4/5)
(+info)Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood. (5/5)
(+info)The symptoms of oligodendroglioma can vary depending on the location and size of the tumor, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior.
Oligodendrogliomas are diagnosed through a combination of imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options for oligodendroglioma can include surgery to remove the tumor, radiation therapy, and chemotherapy with drugs such as temozolomide.
Prognosis for oligodendroglioma depends on the location, size, and aggressiveness of the tumor, as well as the age and overall health of the patient. In general, benign oligodendrogliomas have a good prognosis, while malignant ones are more difficult to treat and can be associated with a poorer outcome.
There is ongoing research into new treatments for oligodendroglioma, including clinical trials of innovative drugs and therapies.
Brain neoplasms can arise from various types of cells in the brain, including glial cells (such as astrocytes and oligodendrocytes), neurons, and vascular tissues. The symptoms of brain neoplasms vary depending on their size, location, and type, but may include headaches, seizures, weakness or numbness in the limbs, and changes in personality or cognitive function.
There are several different types of brain neoplasms, including:
1. Meningiomas: These are benign tumors that arise from the meninges, the thin layers of tissue that cover the brain and spinal cord.
2. Gliomas: These are malignant tumors that arise from glial cells in the brain. The most common type of glioma is a glioblastoma, which is aggressive and hard to treat.
3. Pineal parenchymal tumors: These are rare tumors that arise in the pineal gland, a small endocrine gland in the brain.
4. Craniopharyngiomas: These are benign tumors that arise from the epithelial cells of the pituitary gland and the hypothalamus.
5. Medulloblastomas: These are malignant tumors that arise in the cerebellum, specifically in the medulla oblongata. They are most common in children.
6. Acoustic neurinomas: These are benign tumors that arise on the nerve that connects the inner ear to the brain.
7. Oligodendrogliomas: These are malignant tumors that arise from oligodendrocytes, the cells that produce the fatty substance called myelin that insulates nerve fibers.
8. Lymphomas: These are cancers of the immune system that can arise in the brain and spinal cord. The most common type of lymphoma in the CNS is primary central nervous system (CNS) lymphoma, which is usually a type of B-cell non-Hodgkin lymphoma.
9. Metastatic tumors: These are tumors that have spread to the brain from another part of the body. The most common types of metastatic tumors in the CNS are breast cancer, lung cancer, and melanoma.
These are just a few examples of the many types of brain and spinal cord tumors that can occur. Each type of tumor has its own unique characteristics, such as its location, size, growth rate, and biological behavior. These factors can help doctors determine the best course of treatment for each patient.
Carbonic anhydrase
Carbonic anhydrase 4
Carbonic anhydrase 13
Carbonic anhydrase VI
Carbonic anhydrase II
Carbonic anhydrase 12
Carbonic anhydrase 9
Carbonic anhydrase inhibitor
Carbonic anhydrase 14
Carbonic anhydrase 7
Carbonic anhydrase 5B, mitochondrial
Carbonic anhydrase 5A, mitochondrial
Carbonic anhydrase III, muscle specific
Bicarbonate buffer system
Diclofenamide
Angela Casini
Amphetamine
Topiramate
CA11
Chlortalidone
Metalloprotein
Carbonic acid
Turnover number
Progestogen ester
Granatin A
William S. Sly
Progesterone 3-acetyl enol ether
Cadmium cycle
Corilagin
Alan J. Russell
List of diseases (C)
Biometal (biology)
Physiological effects in space
Loop diuretic
Winifred Ashby
Glaucoma
Zinc in biology
Mafenide
Metformin
Cyanase
Hydroflumethiazide
Seagrass
CA6
Acid-base homeostasis
Streptomyces sioyaensis
Sodium-hydrogen antiporter 1
Chloride anion exchanger
Normal anion gap acidosis
Hydrophobic effect
Estrone sulfamate
CA8
Cai
Clofenamide
Saliva
PTPRZ1
6NJ3: Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233
DailyMed - Search Results for Carbonic Anhydrase Inhibitor
Carbonic anhydrase VA deficiency: MedlinePlus Genetics
SCOP 1.57: Superfamily c.53.2: beta-carbonic anhydrase, cab
Unilateral Glaucoma Medication: Beta-adrenergic blockers, Alpha 2-adrenergic agonists, Carbonic anhydrase inhibitors,...
Carbonic Anhydrase Inhibitors - LiverTox - NCBI Bookshelf
Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood ...
An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii[v1] | Preprints.org
Reactome | Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide
carbonic anhydrase 7 | Carbonic anhydrases | IUPHAR/BPS Guide to PHARMACOLOGY
Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity...
Carbonic Anhydrase IV | Profiles RNS
Carbonic Anhydrase-1 Human Recombinant - GentaurTop
Recombinant Human Carbonic Anhydrase II / CA2 Protein - enQuire BioReagents
Carbonic Anhydrase family as target for rational drug design
Carbonic anhydrase, the protein controlling aging - Work for human longevity
Carbonic anhydrase IX in oligodendroglial brain tumors | BMC Cancer | Full Text
Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition
Pages that link to Design and synthesis of some new benzoylthioureido benzene sulfonamide derivatives and their analogues as...
DailyMed - Search Results for Carbonic Anhydrase Inhibitor
An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics - Oxford Cardiovascular Science
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral...
Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells...
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. -...
Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. - MRC Weatherall Institute of...
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and...
Inhibitors6
- Medications used to decrease aqueous production include beta-blockers (topical), carbonic anhydrase inhibitors (topical and/or oral), and alpha 2-agonists. (medscape.com)
- Carbonic anhydrase (CA) inhibitors are active over a number of CA isozymes. (guidetopharmacology.org)
- 2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety. (guidetopharmacology.org)
- First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. (ox.ac.uk)
- Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. (medscape.com)
- Concomitant administration of oral carbonic anhydrase inhibitors. (who.int)
Recombinant Protein1
- Description: Carbonic anhydrase 2 Human Recombinant protein produced in E.Coli containing 260 amino acids (1-260) and having a molecular mass of 29.2 kDa. (gentaurtop.com)
Enzyme6
- This gene provides instructions for making the carbonic anhydrase VA enzyme, which helps convert carbon dioxide to a substance called bicarbonate. (medlineplus.gov)
- The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes in the energy-producing centers of cells (mitochondria). (medlineplus.gov)
- Mutations in the CA5A gene result in absent or impaired carbonic anhydrase VA enzyme function, leading to reduced bicarbonate production. (medlineplus.gov)
- Studies suggest that a related enzyme produced from the CA5B gene may increasingly compensate for the lack of carbonic anhydrase VA as affected individuals mature, which may result in a reduced risk of metabolic crisis and acute encephalopathy after childhood. (medlineplus.gov)
- Description: Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. (gentaurtop.com)
- Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion. (biomedcentral.com)
Deficiency9
- Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain substances in the body is disrupted (known as metabolic crisis) and brain function is abnormal (known as acute encephalopathy). (medlineplus.gov)
- During an episode, people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base balance in the blood (metabolic acidosis and respiratory alkalosis), low glucose in the blood (hypoglycemia), and reduced production of a substance called bicarbonate in the liver. (medlineplus.gov)
- People with carbonic anhydrase VA deficiency typically first experience episodes of the disorder by age 2. (medlineplus.gov)
- Between episodes, children with carbonic anhydrase VA deficiency are generally healthy, and more than half have no further episodes after the first one. (medlineplus.gov)
- Because of the small number of people with carbonic anhydrase VA deficiency who have come to medical attention, the effects of this disorder in adults are not well understood. (medlineplus.gov)
- The prevalence of carbonic anhydrase VA deficiency is unknown. (medlineplus.gov)
- researchers suspect that some babies diagnosed with transient hyperammonemia may actually have carbonic anhydrase VA deficiency. (medlineplus.gov)
- Carbonic anhydrase VA deficiency is caused by mutations in the CA5A gene. (medlineplus.gov)
- Insufficient bicarbonate results in impaired control of acid-base balance and reduces the activity of the four affected mitochondrial enzymes, resulting in the various biochemical abnormalities associated with carbonic anhydrase VA deficiency. (medlineplus.gov)
Hydration of carbon dioxide2
- Catalyzes reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. (medscape.com)
- Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate. (ox.ac.uk)
Abstract1
- ABSTRACT ß- Carbonic anhydrase (ßCA) is very important for plant growth and development , but its function in immunity has also been examined. (bvsalud.org)
Protein1
- Carbonic anhydrase, the miracle protein? (longlonglife.org)
Activators2
- 3. Tanini D, Capperucci A, Supuran CT, Angeli A. (2019) Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators. (guidetopharmacology.org)
- 2006) Carbonic anhydrase activators. (guidetopharmacology.org)
Metalloenzymes2
- Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. (preprints.org)
- A biochemist research team at Nottingham University found out that carbonic anhydrases (CAs) , a group of ubiquitous metalloenzymes present in mitochondria, could be connected to cellular degeneration and the aging process . (longlonglife.org)
Concentration1
- The biochemists, Dr. Lisa Chakrabarti and PhD student Amelia Pollard, also found carbonic anhydrase in high concentration in young mice brain with degenerative brain disorders . (longlonglife.org)
Carbon1
- Catalyzes a reversible reaction where carbon dioxide becomes hydrated and carbonic acid dehydrated. (medscape.com)
Human3
- A DNA sequence encoding the Homo sapiens (Human) Carbonic Anhydrase II / CA2, was expressed in the hosts and tags indicated. (enquirebio.com)
- Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. (maastrichtuniversity.nl)
- Additionally, using western blot and ELISA assays, we verified that carbonic anhydrase 1 (CA1, UniProtKB - P00915, CAH1_HUMAN) and hemoglobin subunit beta (HBB, UniProtKB - P68871, HBB_HUMAN) proteins are highly expressed during the ulcerative and remission phases of recurrent aphthous stomatitis. (medrxiv.org)
Family1
- An interesting example is offered by the family of Carbonic Anhydrases (CAs, EC 4. (cnr.it)
Biological1
- Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. (gentaurtop.com)
Oral1
- Potential additive effect of oral carbonic anhydrase inhibitor with dorzolamide hydrochloride ophthalmic solution. (nih.gov)
Found1
- A membrane-bound carbonic anhydrase found in lung capillaries and kidney. (ouhsc.edu)
Target1
- Carbonic anhydrases (CAs) continue to represent a relevant pharmaceutical target. (unipr.it)
Links1
- This discovery adds further links of carbonic anhydrase to the consequences of the aging processes. (longlonglife.org)
People2
- This graph shows the total number of publications written about "Carbonic Anhydrase IV" by people in this website by year, and whether "Carbonic Anhydrase IV" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Carbonic Anhydrase IV" by people in Profiles. (ouhsc.edu)
Treatment1
- Dorzolamide hydrochloride ophthalmic solution is a carbonic anhydrase inhibitor indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. (nih.gov)
Potential1
- Recently, ß-carbonic anhydrases (ß-CAs) have emerged as potential drug targets in mycobacteria. (bvsalud.org)
Inhibitor1
- Carbonic anhydrase inhibitor, but the exact mechanism by which dichlorphenamide is able to treat periodic paralysis is unknown. (medscape.com)
Liver1
- Liver carbonic anhydrase and urea synthesis. (nih.gov)