Carbonic Anhydrase V
Carbonic Anhydrases
Carbonic Anhydrase Inhibitors
Carbonic Anhydrase II
Carbonic Anhydrase III
Carbonic Anhydrase I
Acetazolamide
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Ethoxzolamide
Benzolamide
Methazolamide
Oligodendroglioma
A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Oncogenes
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.
Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. (1/5)
(+info)Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. (2/5)
(+info)Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer. (3/5)
(+info)Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. (4/5)
(+info)Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood. (5/5)
(+info) Oligodendroglioma is a rare type of brain tumor that develops from oligodendrocytes, which are cells that provide support and insulation to nerve fibers in the central nervous system. It is typically slow-growing and can be benign (non-cancerous) or malignant (cancerous).
The symptoms of oligodendroglioma can vary depending on the location and size of the tumor, but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior.
Oligodendrogliomas are diagnosed through a combination of imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options for oligodendroglioma can include surgery to remove the tumor, radiation therapy, and chemotherapy with drugs such as temozolomide.
Prognosis for oligodendroglioma depends on the location, size, and aggressiveness of the tumor, as well as the age and overall health of the patient. In general, benign oligodendrogliomas have a good prognosis, while malignant ones are more difficult to treat and can be associated with a poorer outcome.
There is ongoing research into new treatments for oligodendroglioma, including clinical trials of innovative drugs and therapies.
A brain neoplasm, also known as a brain tumor, is an abnormal growth of tissue in the brain that can be benign or malignant. Benign brain tumors are non-cancerous and do not spread to other parts of the body, while malignant brain tumors are cancerous and can invade surrounding tissue and spread to other parts of the body.
Brain neoplasms can arise from various types of cells in the brain, including glial cells (such as astrocytes and oligodendrocytes), neurons, and vascular tissues. The symptoms of brain neoplasms vary depending on their size, location, and type, but may include headaches, seizures, weakness or numbness in the limbs, and changes in personality or cognitive function.
There are several different types of brain neoplasms, including:
1. Meningiomas: These are benign tumors that arise from the meninges, the thin layers of tissue that cover the brain and spinal cord.
2. Gliomas: These are malignant tumors that arise from glial cells in the brain. The most common type of glioma is a glioblastoma, which is aggressive and hard to treat.
3. Pineal parenchymal tumors: These are rare tumors that arise in the pineal gland, a small endocrine gland in the brain.
4. Craniopharyngiomas: These are benign tumors that arise from the epithelial cells of the pituitary gland and the hypothalamus.
5. Medulloblastomas: These are malignant tumors that arise in the cerebellum, specifically in the medulla oblongata. They are most common in children.
6. Acoustic neurinomas: These are benign tumors that arise on the nerve that connects the inner ear to the brain.
7. Oligodendrogliomas: These are malignant tumors that arise from oligodendrocytes, the cells that produce the fatty substance called myelin that insulates nerve fibers.
8. Lymphomas: These are cancers of the immune system that can arise in the brain and spinal cord. The most common type of lymphoma in the CNS is primary central nervous system (CNS) lymphoma, which is usually a type of B-cell non-Hodgkin lymphoma.
9. Metastatic tumors: These are tumors that have spread to the brain from another part of the body. The most common types of metastatic tumors in the CNS are breast cancer, lung cancer, and melanoma.
These are just a few examples of the many types of brain and spinal cord tumors that can occur. Each type of tumor has its own unique characteristics, such as its location, size, growth rate, and biological behavior. These factors can help doctors determine the best course of treatment for each patient.
Carbonic anhydrase
Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Carbonic anhydrase inhibitor Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant ... Carbonic anhydrase could in principle prove relevant to carbon capture. Some carbonic anhydrases can withstand temperatures up ... Class one being alpha carbonic anhydrase which is found in mammals, class two being beta carbonic anhydrase which is found in ...
Carbonic anhydrase 4
... is an enzyme that in humans is encoded by the CA4 gene. Carbonic anhydrases (CAs) are a large family of ... "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from ... Other forms of carbonic anhydrase enzyme are not present in the plasma, restricting the equilibrium reaction of CO2+H2O = H 2CO ... "Entrez Gene: CA4 carbonic anhydrase IV". Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a ...
Carbonic anhydrase 13
... is a protein that in humans is encoded by the CA13 gene. Carbonic anhydrases (CAs) are a family of zinc ... "Entrez Gene: Carbonic anhydrase 13". Retrieved 2019-12-31. Badger MR, Price GD (1994). "The role of carbonic anhydrase in ... Overview of all the structural information available in the PDB for UniProt: Q8N1Q1 (Human Carbonic anhydrase 13) at the PDBe- ... January 2004). "Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family". The Journal of ...
Carbonic anhydrase VI
Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence ... "Entrez Gene: CA6 carbonic anhydrase VI". Henkin RI, Mueller CW, Wolf RO (July 1975). "Estimation of zinc concentration of ... The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary ... Aldred P, Fu P, Barrett G, Penschow JD, Wright RD, Coghlan JP, Fernley RT (January 1991). "Human secreted carbonic anhydrase: ...
Carbonic anhydrase II
... (gene name CA2), is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes ... Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Loss of carbonic anhydrase ... Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi ...
Carbonic anhydrase 12
... is an enzyme that in humans is encoded by the CA12 gene. Carbonic anhydrases (CAs) are a large family of ... "Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is ... "Entrez Gene: CA12 carbonic anhydrase XII". Feldshtein, M; Elkrinawi, S; Yerushalmi, B; Marcus, B; Vullo, D; Romi, H; Ofir, R; ... Tarun AS, Bryant B, Zhai W, Solomon C, Shusterman D (2004). "Gene expression for carbonic anhydrase isoenzymes in human nasal ...
Carbonic anhydrase 9
Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonic ... "Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases". Sub-Cellular Biochemistry. Carbonic ... "Entrez Gene: CA9 carbonic anhydrase IX". Morgan PE, Pastoreková S, Stuart-Tilley AK, Alper SL, Casey JR (August 2007). " ... Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. ...
Carbonic anhydrase inhibitor
... s are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical ... are carbonic anhydrase inhibitors. Supuran CT, Scozzafava A, Conway J, eds. (2004). Carbonic anhydrase: its inhibitors and ... "Carbonic Anhydrase Inhibitors and High Altitude Illnesses". In Frost, Susan C.; McKenna, Robert (eds.). Carbonic Anhydrase: ... Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. They may also be used to treat seizure disorder ...
Carbonic anhydrase 14
... is an enzyme that in humans is encoded by the CA14 gene. Carbonic anhydrases (CAs) are a large family of ... "Entrez Gene: CA14 carbonic anhydrase XIV". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified ... 2002). "Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification". Kidney Int. 61 (6): 2111-8. doi: ... Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Nov 1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA ...
Carbonic anhydrase 7
"Entrez Gene: CA7 carbonic anhydrase VII". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies ... Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene. Carbonic anhydrases are a large family of ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7 v t e ( ... Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors ...
Carbonic anhydrase 5B, mitochondrial
... is an enzyme that in humans is encoded by the CA5B gene. Carbonic anhydrases (CAs) are a ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64: 375-401. doi: ... "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial". Human CA5B genome location and CA5B gene details page in the UCSC ... 2007). "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and ...
Carbonic anhydrase 5A, mitochondrial
... is a protein that in humans is encoded by the CA5A gene. Carbonic anhydrases (CAs) are a ... "Entrez Gene: Carbonic anhydrase 5A". Retrieved 2019-12-31. Vullo D, Nishimori I, Innocenti A, Scozzafava A, Supuran CT (March ... March 2014). "Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in ... "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines". ...
Carbonic anhydrase III, muscle specific
CA3 carbonic anhydrase III, muscle specific". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase ... Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene. Carbonic anhydrase III (CAIII) is a member of a ... that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible ... Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis ...
Bicarbonate buffer system
Catalyzed by carbonic anhydrase, carbon dioxide (CO2) reacts with water (H2O) to form carbonic acid (H2CO3), which in turn ... Meldrum, N. U.; Roughton, F. J. W. (1933-12-05). "Carbonic anhydrase. Its preparation and properties". The Journal of ... causing carbonic anhydrase to form CO2 until all excess protons are removed. Bicarbonate concentration is also further ... are facilitated by carbonic anhydrase in both the blood and duodenum. While in the blood, bicarbonate ion serves to neutralize ...
Diclofenamide
"Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British Journal of ... is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. Dichlorphenamide as a carbonic ... it falls under the class of a first generation carbonic anhydrase Inhibitor. Diclofenamide was approved in the United States in ... Carbonic anhydrase inhibitors, Sulfonamides, Chlorobenzenes, Ophthalmology drugs, All stub articles, Antihypertensive agent ...
Angela Casini
Casini, Angela (2004). "Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH". ... Casini, Angela (2004). "Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological ... "Carbonic anhydrase inhibitors". Medicinal Research Reviews. 23 (2): 146-189. doi:10.1002/med.10025. PMID 12500287. S2CID ...
Amphetamine
... cerebral carbonic anhydrase activation has cognition-enhancing effects; but, based upon the clinical use of carbonic anhydrase ... CARBONIC ANHYDRASE INHIBITORS (CAIs). The design and development of CAIs represent the most prolific area within the CA ... Bozdag M, Altamimi AA, Vullo D, Supuran CT, Carta F (2019). "State of the Art on Carbonic Anhydrase Modulators for Biomedical ... Amphetamine also activates seven human carbonic anhydrase enzymes, several of which are expressed in the human brain. ...
Topiramate
... forms of carbonic anhydrase. The action on carbonic anhydrase isoenzymes may contribute to the drug's side-effects, including ... As topiramate inhibits carbonic anhydrase, use with other inhibitors of carbonic anhydrase (e.g. acetazolamide) increases the ... Topiramate, sold under the brand name Topamax among others, is a carbonic anhydrase inhibitor medication used to treat epilepsy ... the inhibition of carbonic anhydrase may be strong enough to cause metabolic acidosis of clinical importance. The U.S. Food and ...
CA11
Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene. Carbonic anhydrases (CAs) are a ... "Entrez Gene: CA11 carbonic anhydrase XI". Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El- ... Bellingham J, Gregory-Evans K, Gregory-Evans CY (1998). "Sequence and tissue expression of a novel human carbonic anhydrase- ... Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S (2001). "cDNA sequence of human carbonic anhydrase-related ...
Chlortalidone
Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. Chronic ... Johnston MM, Li H, Mufson D (December 1977). "Chlorthalidone analysis using carbonic anhydrase inhibition". J Pharm Sci. 66 (12 ... Carbonic anhydrase inhibitors, World Anti-Doping Agency prohibited substances). ... it also strongly inhibits multiple isoforms of carbonic anhydrase. ...
Metalloprotein
3 A reaction similar to this is almost instantaneous with carbonic anhydrase. The structure of the active site in carbonic ... Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi:10.1016/ ... In aqueous solution, carbon dioxide forms carbonic acid CO2 + H2O ⇌ H2CO3 This reaction is very slow in the absence of a ... H+ favours dissociation of carbonic acid at biological pH values. The cobalt-containing Vitamin B12 (also known as cobalamin) ...
Carbonic acid
When the enzyme carbonic anhydrase is also present in the solution the following reaction takes precedence. HCO 3 − + H ... Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi:10.1016/ ... Carbon dioxide can be described as the anhydride of carbonic acid. Carbonic acid, H2CO3, is quite stable at ambient ... "carbonic acid" in biochemistry literature. Since pKa1 has a value of ca. 6.8, at equilibrium carbonic acid will be almost 50% ...
Turnover number
Carbonic anhydrase is one of the fastest enzymes, and its rate is typically limited by the diffusion rate of its substrates. ... Lindskog, Sven (January 1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi: ...
Progestogen ester
"Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase as indicator of luteoid potency: ...
Granatin A
It is a weak carbonic anhydrase inhibitor. Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic ... anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. doi: ...
William S. Sly
Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi:10.1146/annurev.bi. ... Roth DE, Venta PJ, Tashian RE, Sly WS (1992). "Molecular basis of human carbonic anhydrase II deficiency". Proc. Natl. Acad. ... Sly also identified the first inherited deficiency of a human carbonic anhydrase, CA II, and defined the biochemical and ...
Progesterone 3-acetyl enol ether
"Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase as indicator of luteoid potency: ... to possess similar potency to progesterone and hydroxyprogesterone caproate in the rabbit endometrial carbonic anhydrase test, ...
Cadmium cycle
Cadmium Carbonic anhydrase Diatoms Cullen, Jay T.; Maldonado, Maria T. (2013). "Biogeochemistry of Cadmium and Its Release to ...
Corilagin
doi:10.1016/S0031-9422(00)83125-8. Satomi H, Umemura K, Ueno A, Hatano T, Okuda T, Noro T (August 1993). "Carbonic anhydrase ... It is a weak carbonic anhydrase inhibitor. Ellagic acid and corilagin inhibit TGF-β1-dependent EMT and has been shown to ...
Alan J. Russell
Carbon Dioxide Removal from e.g. Blood using Membrane and Immobilized Carbonic Anhydrase; Artificial Lung for Example, US ...
List of diseases (C)
Carbohydrate deficient glycoprotein syndrome Carbon baby syndrome Carbonic anhydrase II deficiency Carcinoid syndrome Carcinoma ...
Biometal (biology)
... for the need of zinc in human cells was shown until the late 1930s where its presence was demonstrated in carbonic anhydrase ...
Physiological effects in space
... such as carbonic anhydrase II and myoglobin, over that predicted by the overall decrease in muscle protein synthesis. In ... "Effect of immobilization on carbonic anhydrase III and myoglobin content in human leg muscle". Acta Physiologica Scandinavica. ...
Loop diuretic
Thiazide (blockade of sodium-chloride symporter), amiloride (blockade of epithelial sodium channels) and carbonic anhydrase ...
Winifred Ashby
She also contributed many studies of the carbonic anhydrase activity of the central nervous system. Women of Mayo Clinic Laura ...
Glaucoma
Carbonic anhydrase inhibitors decrease bicarbonate formation from ciliary processes in the eye, thus decreasing the formation ... Carbonic anhydrase inhibitors, such as dorzolamide, brinzolamide, and acetazolamide, lower secretion of aqueous humor by ... carbonic anhydrase inhibitors in the mid-1990s.. Early surgical techniques like iridectomy and fistulating methods have ... inhibiting carbonic anhydrase in the ciliary body. Poor compliance with medications and follow-up visits is a major reason for ...
Zinc in biology
In vertebrate blood, carbonic anhydrase converts CO 2 into bicarbonate and the same enzyme transforms the bicarbonate back into ... The non-related β-carbonic anhydrase is required in plants for leaf formation, the synthesis of indole acetic acid (auxin) and ... Two examples of zinc-containing enzymes are carbonic anhydrase and carboxypeptidase, which are vital to the processes of carbon ...
Mafenide
... is metabolized to a carbonic anhydrase inhibitor, which could potentially result in metabolic acidosis.[citation ...
Metformin
... carbonic anhydrase inhibitors such as topiramate), surgery, and other procedures, or in people having a radiological study with ...
Cyanase
... a combined application of cyanase and carbonic anhydrase has been used in a study. Qian D, Jiang L, Lu L, Wei C, Li Y (March ...
Hydroflumethiazide
Carbonic anhydrase inhibitors, All stub articles, Cardiovascular system drug stubs). ...
Seagrass
Towards a model for inorganic carbon uptake in seagrasses involving carbonic anhydrase. In Kuo J, Phillips RC, Walker DI, ...
CA6
... may refer to : Carbonic anhydrase VI, a human gene United States Court of Appeals for the Sixth Circuit CA-6 may refer to ...
Acid-base homeostasis
3 through the action of carbonic anhydrase. When the extracellular fluids tend towards acidity, the renal tubular cells secrete ... H2CO3] is the molar concentration of carbonic acid in the extracellular fluid. However, since the carbonic acid concentration ... There, carbonic acid spontaneously dissociates into hydrogen ions and bicarbonate ions. When the pH in the ECF falls, hydrogen ... pKa H2CO3 is the cologarithm of the acid dissociation constant of carbonic acid. It is equal to 6.1. [HCO− 3] is the molar ...
Streptomyces sioyaensis
ISBN 0-08-086577-1. editors, Susan C. Frost, Robert McKenna (2014). Carbonic Anhydrase: Mechanism, Regulation, Links to Disease ...
Sodium-hydrogen antiporter 1
... has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the ... Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of ...
Chloride anion exchanger
"The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II". American Journal ...
Normal anion gap acidosis
... often from normal saline Acetazolamide and other carbonic anhydrase inhibitors Renal tubular acidosis Diarrhea: due to a loss ...
Hydrophobic effect
"The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand". ...
Estrone sulfamate
The sulfamate moiety of EMATE results in carbonic anhydrase binding which, in turn, results in EMATE being taken up into and ...
CA8
... continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase ... Carbonic anhydrase-related protein is a protein that in humans is encoded by the CA8 gene. The CA8 protein lacks the catalytic ... Bergenhem NC, Sait SS, Eddy RL, Shows TB, Tashian RE (1995). "Assignment of the gene for human carbonic anhydrase VIII(CA8) to ... "Entrez Gene: CA8 carbonic anhydrase VIII". UniProt accession number: P35219; Retrieved 27 December 2019 Online Mendelian ...
Cai
... a type of mineral Carbonic anhydrase inhibitor, in pharmacology Codon Adaptation Index, a measure of codon bias in protein- ...
Clofenamide
Carbonic anhydrase inhibitors, All stub articles, Cardiovascular system drug stubs). ...
Saliva
... secretes carbonic anhydrase (gustin), which is thought to play a role in the development of taste buds. Saliva contains ...
PTPRZ1
... an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein ... is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. ...
6NJ3: Thermostable variant of human carbonic anhydrase with ordered tetrazine 2.0 at site 233
DailyMed - Search Results for Carbonic Anhydrase Inhibitor
Carbonic anhydrase VA deficiency: MedlinePlus Genetics
Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes of metabolic crisis abnormal brain function ... Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401. doi: 10.1146/annurev.bi. ... Hyperammonemia due to carbonic anhydrase VA deficiency. *Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency ... medlineplus.gov/genetics/condition/carbonic-anhydrase-va-deficiency/ Carbonic anhydrase VA deficiency. ...
SCOP 1.57: Superfamily c.53.2: beta-carbonic anhydrase, cab
... beta-carbonic anhydrase, cab. Timeline for Superfamily c.53.2: beta-carbonic anhydrase, cab: *Superfamily c.53.2: beta-carbonic ... Superfamily c.53.2: beta-carbonic anhydrase, cab appears in SCOP 1.59. *Superfamily c.53.2: beta-carbonic anhydrase, cab ... Lineage for Superfamily c.53.2: beta-carbonic anhydrase, cab. *Root: SCOP 1.57 *. Class c: Alpha and beta proteins (a/b) [51349 ... c.53.2.1: beta-carbonic anhydrase, cab [53057] (1 protein). More info for Superfamily c.53.2: ...
Unilateral Glaucoma Medication: Beta-adrenergic blockers, Alpha 2-adrenergic agonists, Carbonic anhydrase inhibitors,...
Carbonic anhydrase inhibitors. Class Summary. Enzyme found in many tissues of the body, including the eye. Catalyzes a ... Medications used to decrease aqueous production include beta-blockers (topical), carbonic anhydrase inhibitors (topical and/or ... Catalyzes reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. May use concomitantly ... reversible reaction where carbon dioxide becomes hydrated and carbonic acid dehydrated. By slowing the formation of bicarbonate ...
Carbonic Anhydrase Inhibitors - LiverTox - NCBI Bookshelf
Acetazolamide and methazolamide are carbonic anhydrase inhibitors used as diuretics and in the therapy of glaucoma. Both ... Liver carbonic anhydrase and urea synthesis. The effect of diuretics.[Biochem Pharmacol. 1986]. Liver carbonic anhydrase and ... Recent References on Carbonic Anhydrase Inhibitors: from PubMed.gov * Trials on Carbonic Anhydrase Inhibitors: from ... are inhibitors of carbonic anhydrase, an enzyme that converts carbon dioxide and water to carbonic acid. Inhibition of this ...
Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood ...
Samples were probed for CA-VA, cytochrome c (Cyto-c), carbonic anhydrase XIV (CA 14), and carbonic anhydrase II (CA 2) via ... Carbonic Anhydrase VA Deficiency. van Karnebeek C, Häberle J. van Karnebeek C, et al. 2015 Apr 2 [updated 2021 Aug 26]. In: ... A case of carbonic anhydrase type VA deficiency presenting as West syndrome in an infant with a novel mutation in the CA-VA ... Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. Aspatwar A, Supuran CT, Waheed A, Sly ...
![An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii[v1] | Preprints.org](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAA0AAAAQCAMAAAD6fQULAAAAS1BMVEVHcEz/vwD1yyf9vwf/vgD+vgH5wRP/vgAABzj+vwj7whIABzj7vw3+vgT+vgX+0hX+vwsAADr9vwf8wA38vwYAAD6mfSKMfDT/vgBFulgmAAAAGHRSTlMA+g6x890j7bGGN2p61MkWkE6bbkko3Rhzgv8fAAAAc0lEQVQImV2OSRbEIAgFQTHG2Qzd4f4nDair1Ip6/z8AQIn3bWDRWanbkMKXBLFyFMnc4EjpB9Zr1GFXjsbSdeFraTRpmPk/uoXKzFAvWDubJl85B0c4jUnwXs12g36Acm87l2EYrzWWmdiut0N15Yzw5QXqAAXjnm3RwAAAAABJRU5ErkJggg==)
An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii[v1] | Preprints.org
Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. The CAs catalyze the basic reaction of reversible ... An Update on the Metabolic Roles of Carbonic Anhydrases in a Model Alga Chlamydomonas reinhardtii. Ashok Aspatwar ... Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. The CAs catalyze the basic reaction of reversible ... Aspatwar, A.; Haapanen, S.; Parkkila, S. An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga ...
Reactome | Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide
CARBONIC ANHYDRASE 9
carbonic anhydrase 7 | Carbonic anhydrases | IUPHAR/BPS Guide to PHARMACOLOGY
carbonic anhydrase 7 - Carbonic anhydrases. Detailed annotation on the structure, function, physiology, pharmacology and ... 2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII ... Carbonic anhydrases: carbonic anhydrase 7. Last modified on 25/07/2019. Accessed on 10/06/2023. IUPHAR/BPS Guide to ... Carbonic anhydrase (CA) inhibitors are active over a number of CA isozymes. We tag those isozymes with the highest drug ...
Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity...
Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity ... Novel synthesized SLC-0111 thiazole and thiadiazole analogues: Determination of their carbonic anhydrase inhibitory activity ... analogues were evaluated in vitro for their inhibitory activity towards a panel of the metalloenzyme carbonic anhydrase (CA, EC ... analogues were evaluated in vitro for their inhibitory activity towards a panel of the metalloenzyme carbonic anhydrase (CA, EC ...
Carbonic Anhydrase IV | Profiles RNS
"Carbonic Anhydrase IV" by people in this website by year, and whether "Carbonic Anhydrase IV" was a major or minor topic of ... "Carbonic Anhydrase IV" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Carbonic Anhydrase IV" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Carbonic Anhydrase IV". ...
Carbonic Anhydrase-1 Human Recombinant - GentaurTop
Carbonic Anhydrase-1 Human Recombinant. Carbonic Anhydrase-1 Human Recombinant. Contact us: [email protected] ... Description: Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly ... Carbonic anhydrase is expressedwith an amino-terminal hexahistidine tag.;The Carbonic anhydrase 2 is purified by proprietary ... Description: Carbonic anhydrase II is an E.coli Recombinant protein produced in E.Coli containing 240 amino acids (1-220) and ...
Recombinant Human Carbonic Anhydrase II / CA2 Protein - enQuire BioReagents
Recombinant Human Carbonic Anhydrase II / CA2 Protein. Synthesized in e. coli. Protein Tag: His-SUMO. Purity: Greater than 90% ... Recombinant Human Carbonic Anhydrase II / CA2 Protein. $ 398.00 - $ 1,728.00. Please Select Product Options Below To View The ... Be the first to review "Recombinant Human Carbonic Anhydrase II / CA2 Protein" Cancel reply. Your email address will not be ... Human Carbonic Anhydrase II / CA2 Recombinant Protein Product Attributes. Product Type: Recombinant Protein ...
Carbonic Anhydrase family as target for rational drug design
... ▼ Carbonic Anhydrase IX as target for the development of new anti ... Carbonic Anhydrase VII (215 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 151-168.. Impact Factor: 0. View ... Carbonic Anhydrases: An Overview (235 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 3-13.. Impact Factor: 0. ... Carbonic Anhydrase II as Target for Drug Design (262 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 51-90.. ...
Carbonic anhydrase, the protein controlling aging - Work for human longevity
Carbonic anhydrases (CAs), a group of ubiquitous metalloenzymes present inside mitochondrias, could be connected to cellular ... Carbonic Anhydrase IX in Mouse Colon. A biochemist research team at Nottingham University found out that carbonic anhydrases ( ... Moreover, by feeding carbonic anhydrases to nematode worms, the researchers also noticed a reduction of the worms lifespan, ... Carbonic anhydrases are involved in many physiological and pathological processes such as gluconeogenesis, lipogenesis, ...
Carbonic anhydrase IX in oligodendroglial brain tumors | BMC Cancer | Full Text
Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell ... Sly W, Hu P: Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995, 64: 375-401. 10.1146/ ... Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b] ... Järvelä, S., Parkkila, S., Bragge, H. et al. Carbonic anhydrase IX in oligodendroglial brain tumors. BMC Cancer 8, 1 (2008). ...
Carbonic anhydrase IX inhibition is an effective strategy for osteosarcoma treatment
Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition
Carbonic anhydrases (CAs) continue to represent a relevant pharmaceutical target. The need of selective inhibitors and the ... Carbonic anhydrases (CAs) continue to represent a relevant pharmaceutical target. The need of selective inhibitors and the ... Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition. Sbravati, Davide;Bonardi ... Calixarenes Incorporating Sulfonamide Moieties: Versatile Ligands for Carbonic Anhydrases Inhibition / Sbravati, Davide; ...
Pages that link to Design and synthesis of some new benzoylthioureido benzene sulfonamide derivatives and their analogues as...
DailyMed - Search Results for Carbonic Anhydrase Inhibitor
An Extra-Mitochondrial Domain Rich in Carbonic Anhydrase Activity Improves Myocardial Energetics - Oxford Cardiovascular Science
Primate-conserved carbonic anhydrase IV and murine-restricted LY6C1 enable blood-brain barrier crossing by engineered viral...
Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells...
Human carbonic anhydrase (CA) IX has emerged as a promising anticancer. target and a diagnostic biomarker for solid hypoxic ... N2 - Human carbonic anhydrase (CA) IX has emerged as a promising anticancertarget and a diagnostic biomarker for solid hypoxic ... AB - Human carbonic anhydrase (CA) IX has emerged as a promising anticancertarget and a diagnostic biomarker for solid hypoxic ... abstract = "Human carbonic anhydrase (CA) IX has emerged as a promising anticancertarget and a diagnostic biomarker for solid ...
First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. -...
Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate. The role of CA in ... Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate. The role of CA in ... First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. ... First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. ...
Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. - MRC Weatherall Institute of...
... and carbonic anhydrase-9 (CA-9) expression and to correlate the results with recurrence and cancer-specific survival. MATERIALS ... Adenocarcinoma, Aged, Antigens, Neoplasm, Biomarkers, Tumor, Carbonic Anhydrase IX, Carbonic Anhydrases, Disease-Free Survival ... Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. ... Assessment of microvessel density and carbonic anhydrase-9 (CA-9) expression in rectal cancer. ...
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and...
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and ... Keywords: acetophenone, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase, enzyme inhibition, ISOENZYMES HCA I, ... and human carbonic anhydrase isoforms. AChE exists at high concentrations in the brain and red blood cells. BChE is an ...
Inhibitors6
- Medications used to decrease aqueous production include beta-blockers (topical), carbonic anhydrase inhibitors (topical and/or oral), and alpha 2-agonists. (medscape.com)
- Carbonic anhydrase (CA) inhibitors are active over a number of CA isozymes. (guidetopharmacology.org)
- 2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety. (guidetopharmacology.org)
- First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. (ox.ac.uk)
- Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each other's renal tubular secretion, resulting in increased plasma levels. (medscape.com)
- Concomitant administration of oral carbonic anhydrase inhibitors. (who.int)
Recombinant Protein1
- Description: Carbonic anhydrase 2 Human Recombinant protein produced in E.Coli containing 260 amino acids (1-260) and having a molecular mass of 29.2 kDa. (gentaurtop.com)
Enzyme6
- This gene provides instructions for making the carbonic anhydrase VA enzyme, which helps convert carbon dioxide to a substance called bicarbonate. (medlineplus.gov)
- The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes in the energy-producing centers of cells (mitochondria). (medlineplus.gov)
- Mutations in the CA5A gene result in absent or impaired carbonic anhydrase VA enzyme function, leading to reduced bicarbonate production. (medlineplus.gov)
- Studies suggest that a related enzyme produced from the CA5B gene may increasingly compensate for the lack of carbonic anhydrase VA as affected individuals mature, which may result in a reduced risk of metabolic crisis and acute encephalopathy after childhood. (medlineplus.gov)
- Description: Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. (gentaurtop.com)
- Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion. (biomedcentral.com)
Deficiency9
- Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain substances in the body is disrupted (known as metabolic crisis) and brain function is abnormal (known as acute encephalopathy). (medlineplus.gov)
- During an episode, people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base balance in the blood (metabolic acidosis and respiratory alkalosis), low glucose in the blood (hypoglycemia), and reduced production of a substance called bicarbonate in the liver. (medlineplus.gov)
- People with carbonic anhydrase VA deficiency typically first experience episodes of the disorder by age 2. (medlineplus.gov)
- Between episodes, children with carbonic anhydrase VA deficiency are generally healthy, and more than half have no further episodes after the first one. (medlineplus.gov)
- Because of the small number of people with carbonic anhydrase VA deficiency who have come to medical attention, the effects of this disorder in adults are not well understood. (medlineplus.gov)
- The prevalence of carbonic anhydrase VA deficiency is unknown. (medlineplus.gov)
- researchers suspect that some babies diagnosed with transient hyperammonemia may actually have carbonic anhydrase VA deficiency. (medlineplus.gov)
- Carbonic anhydrase VA deficiency is caused by mutations in the CA5A gene. (medlineplus.gov)
- Insufficient bicarbonate results in impaired control of acid-base balance and reduces the activity of the four affected mitochondrial enzymes, resulting in the various biochemical abnormalities associated with carbonic anhydrase VA deficiency. (medlineplus.gov)
Hydration of carbon dioxide2
- Catalyzes reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. (medscape.com)
- Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate. (ox.ac.uk)
Abstract1
- ABSTRACT ß- Carbonic anhydrase (ßCA) is very important for plant growth and development , but its function in immunity has also been examined. (bvsalud.org)
Protein1
- Carbonic anhydrase, the miracle protein? (longlonglife.org)
Activators2
- 3. Tanini D, Capperucci A, Supuran CT, Angeli A. (2019) Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators. (guidetopharmacology.org)
- 2006) Carbonic anhydrase activators. (guidetopharmacology.org)
Metalloenzymes2
- Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. (preprints.org)
- A biochemist research team at Nottingham University found out that carbonic anhydrases (CAs) , a group of ubiquitous metalloenzymes present in mitochondria, could be connected to cellular degeneration and the aging process . (longlonglife.org)
Concentration1
- The biochemists, Dr. Lisa Chakrabarti and PhD student Amelia Pollard, also found carbonic anhydrase in high concentration in young mice brain with degenerative brain disorders . (longlonglife.org)
Carbon1
- Catalyzes a reversible reaction where carbon dioxide becomes hydrated and carbonic acid dehydrated. (medscape.com)
Human3
- A DNA sequence encoding the Homo sapiens (Human) Carbonic Anhydrase II / CA2, was expressed in the hosts and tags indicated. (enquirebio.com)
- Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. (maastrichtuniversity.nl)
- Additionally, using western blot and ELISA assays, we verified that carbonic anhydrase 1 (CA1, UniProtKB - P00915, CAH1_HUMAN) and hemoglobin subunit beta (HBB, UniProtKB - P68871, HBB_HUMAN) proteins are highly expressed during the ulcerative and remission phases of recurrent aphthous stomatitis. (medrxiv.org)
Family1
- An interesting example is offered by the family of Carbonic Anhydrases (CAs, EC 4. (cnr.it)
Biological1
- Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. (gentaurtop.com)
Oral1
- Potential additive effect of oral carbonic anhydrase inhibitor with dorzolamide hydrochloride ophthalmic solution. (nih.gov)
Found1
- A membrane-bound carbonic anhydrase found in lung capillaries and kidney. (ouhsc.edu)
Target1
- Carbonic anhydrases (CAs) continue to represent a relevant pharmaceutical target. (unipr.it)
Links1
- This discovery adds further links of carbonic anhydrase to the consequences of the aging processes. (longlonglife.org)
People2
- This graph shows the total number of publications written about "Carbonic Anhydrase IV" by people in this website by year, and whether "Carbonic Anhydrase IV" was a major or minor topic of these publications. (ouhsc.edu)
- Below are the most recent publications written about "Carbonic Anhydrase IV" by people in Profiles. (ouhsc.edu)
Treatment1
- Dorzolamide hydrochloride ophthalmic solution is a carbonic anhydrase inhibitor indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. (nih.gov)
Potential1
- Recently, ß-carbonic anhydrases (ß-CAs) have emerged as potential drug targets in mycobacteria. (bvsalud.org)
Inhibitor1
- Carbonic anhydrase inhibitor, but the exact mechanism by which dichlorphenamide is able to treat periodic paralysis is unknown. (medscape.com)
Liver1
- Liver carbonic anhydrase and urea synthesis. (nih.gov)