Carbonic Anhydrase V: A carbonic anhydrase isoenzyme found in MITOCHONDRIA where it provides bicarbonate ions that are components in the urea cycle and in GLUCONEOGENESIS.Carbonic Anhydrases: A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.Carbonic Anhydrase Inhibitors: A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.Carbonic Anhydrase II: A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-Carbonic Anhydrase III: A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-Carbonic Anhydrase I: A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial cells, and the gastrointestinal mucosa. EC 4.2.1.-Carbonic Anhydrase IV: A membrane-bound carbonic anhydrase found in lung capillaries and kidney.Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.Benzolamide: Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.Methazolamide: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Pericytes: Unique slender cells with multiple processes extending along the capillary vessel axis and encircling the vascular wall, also called mural cells. Pericytes are imbedded in the BASEMENT MEMBRANE shared with the ENDOTHELIAL CELLS of the vessel. Pericytes are important in maintaining vessel integrity, angiogenesis, and vascular remodeling.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Palaemonidae: A family of CRUSTACEA, order DECAPODA, comprising the palaemonid shrimp. Genera include Macrobrachium, Palaemon, and Palaemonetes. Palaemonidae osmoregulate by means of gills.Hepatopancreas: A primitive form of digestive gland found in marine ARTHROPODS, that contains cells similar to those found in the mammalian liver (HEPATOCYTES), and the PANCREAS.Aquaculture: Cultivation of natural faunal resources of water. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Fresh Water: Water containing no significant amounts of salts, such as water from RIVERS and LAKES.Lactococcus: A genus of gram-positive, coccoid bacteria mainly isolated from milk and milk products. These bacteria are also found in plants and nonsterile frozen and dry foods. Previously thought to be a member of the genus STREPTOCOCCUS (group N), it is now recognized as a separate genus.Nodaviridae: A family of RNA viruses infecting insects and fish. There are two genera: Alphanodavirus and Betanodavirus.Methylophilaceae: A family of gram-negative bacteria in the order Methylophilales.Xenon Isotopes: Stable xenon atoms that have the same atomic number as the element xenon, but differ in atomic weight. Xe-124, 126, 128-131, 134, and 136 are stable xenon isotopes.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Microscopy: The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.Capillaries: The minute vessels that connect the arterioles and venules.Sulfur Oxides: Inorganic oxides of sulfur.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. (1/5)

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Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. (2/5)

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Differential gene expression analysis of peripheral blood mononuclear cells reveals novel test for early detection of pancreatic cancer. (3/5)

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Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism. (4/5)

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Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood. (5/5)

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*Carbonic anhydrase

Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Carbonic anhydrase inhibitor Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant ... Carbonic\ anhydrase}}H_{2}CO_{3}}}} (in tissues - high CO2 concentration) The reaction rate of carbonic anhydrase is one of the ... The mechanism of cadmium carbonic anhydrase (CDCA) is essentially the same as that of other carbonic anhydrases in its ...

*Carbonic anhydrase 4

... is an enzyme that in humans is encoded by the CA4 gene. Carbonic anhydrases (CAs) are a large family of ... "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from ... Other forms of carbonic anhydrase enzyme are not present in the plasma, restricting the equilibrium reaction of CO2+H2O = H2CO3 ... "Entrez Gene: CA4 carbonic anhydrase IV". Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a ...

*Carbonic anhydrase VI

Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence ... "Entrez Gene: CA6 carbonic anhydrase VI". Henkin RI, Mueller CW, Wolf RO (July 1975). "Estimation of zinc concentration of ... The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary ... Aldred P, Fu P, Barrett G, Penschow JD, Wright RD, Coghlan JP, Fernley RT (January 1991). "Human secreted carbonic anhydrase: ...

*Carbonic anhydrase inhibitor

... s are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical ... are carbonic anhydrase inhibitors. Supuran CT, Scozzafava A, Conway J, eds. (2004). Carbonic anhydrase: its inhibitors and ... "Carbonic Anhydrase Inhibitors and High Altitude Illnesses". In Frost, Susan C.; McKenna, Robert. Carbonic Anhydrase: Mechanism ... Carbonic anhydrase inhibitors are primarily used for the treatment of glaucoma. They may also be used to treat seizure disorder ...

*Carbonic anhydrase II

... (gene name CA2), is one of fourteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes ... Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Carbonic anhydrase II has been ... Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi ...

*Carbonic anhydrase 7

"Entrez Gene: CA7 carbonic anhydrase VII". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies ... Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene. Carbonic anhydrases are a large family of ... Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors ... Breton S (Jul 2001). "The cellular physiology of carbonic anhydrases". Jop. 2 (4 Suppl): 159-64. PMID 11875253. Rivera C, ...

*Carbonic anhydrase 9

... (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene. Carbonic anhydrases (CAs) are a large ... "Entrez Gene: CA9 carbonic anhydrase IX". Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E, ... Li J, Zhang G, Wang X, Li XF (2015). "Is carbonic anhydrase IX a validated target for molecular imaging of cancer and hypoxia ... Pastoreková S, Parkkila S, Parkkila AK, Opavský R, Zelník V, Saarnio J, Pastorek J (Feb 1997). "Carbonic anhydrase IX, MN/CA IX ...

*Carbonic anhydrase III, muscle specific

CA3 carbonic anhydrase III, muscle specific". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase ... Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene. Carbonic anhydrase III (CAIII) is a member of a ... that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible ... Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis ...

*Bicarbonate buffer system

Catalyzed by carbonic anhydrase, carbon dioxide (CO2) reacts with water (H2O) to form carbonic acid (H2CO3), which in turn ... Meldrum, N. U.; Roughton, F. J. W. (1933-12-05). "Carbonic anhydrase. Its preparation and properties". The Journal of ... causing carbonic anhydrase to form CO2 until all excess acid is removed. Bicarbonate concentration is also further regulated by ... are facilitated by carbonic anhydrase in both the blood and duodenum. While in the blood, bicarbonate ion serves to neutralize ...

*Diclofenamide

"Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ... Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. ...

*CA5B

Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene. Carbonic anhydrases (CAs) are a ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64: 375-401. doi: ... "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial". Human CA5B genome location and CA5B gene details page in the UCSC ... 2007). "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and ...

*CA8

"Entrez Gene: CA8 carbonic anhydrase VIII". Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related ... continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase ... Carbonic anhydrase-related protein is an enzyme that in humans is encoded by the CA8 gene. The protein encoded by this gene was ... Bergenhem NC, Sait SS, Eddy RL, Shows TB, Tashian RE (1995). "Assignment of the gene for human carbonic anhydrase VIII(CA8) to ...

*CA14

Carbonic anhydrase 14 is an enzyme that in humans is encoded by the CA14 gene. Carbonic anhydrases (CAs) are a large family of ... "Entrez Gene: CA14 carbonic anhydrase XIV". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified ... 2002). "Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification". Kidney Int. 61 (6): 2111-8. doi: ... 2001). "Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain". Proc. Natl. ...

*Metalloprotein

3 A reaction similar to this is almost instantaneous with carbonic anhydrase. The structure of the active site in carbonic ... "Structure and mechanism of carbonic anhydrase". Pharmacol. Ther. 74 (1): 1-20. doi:10.1016/S0163-7258(96)00198-2. PMID 9336012 ... In aqueous solution, carbon dioxide forms carbonic acid CO2 + H2O ⇌ H2CO3 This reaction is very slow in the absence of a ... carbonic anhydride) proceeds rapidly. The catalytic cycle produces the bicarbonate ion and the hydrogen ion as the equilibrium ...

*Granatin A

It is a weak carbonic anhydrase inhibitor. Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic ... anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. doi: ...

*William S. Sly

Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi:10.1146/annurev.bi. ... Roth DE, Venta PJ, Tashian RE, Sly WS (1992). "Molecular basis of human carbonic anhydrase II deficiency". Proc. Natl. Acad. ... Sly also identified the first inherited deficiency of a human carbonic anhydrase, CA II, and defined the biochemical and ...

*Corilagin

"Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ... It is a weak carbonic anhydrase inhibitor. Schmidt, O. T. .; Lademann, R. (1951). "Corilagin, ein weiterer kristallisierter ...

*Alan J. Russell

Carbon Dioxide Removal from e.g. Blood using Membrane and Immobilized Carbonic Anhydrase; Artificial Lung for Example, US ...

*Punicalin

It is a highly active carbonic anhydrase inhibitor. The molecule contains a gallagic acid component linked to a glucose. Zhang ... Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of ...

*Cecilia Lutwak-Mann

Davenport, Horace W. (1984-06-01). "The Early Days of Research on Carbonic Anhydrase". Annals of the New York Academy of ... Lutwak-Mann was known for discovering that the hormone progesterone acts on the placenta to control carbonic anhydrase ... Davenport, Horace W. (1980-04-01). "Carbonic Anhydrase, or the Strange Case of the Disappearing Scientist". The Physiologist. ...

*Granatin B

It is a highly active carbonic anhydrase inhibitor. www.chemicalbook.com Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ...

*Indane-5-sulfonamide

... is a carbonic anhydrase inhibitor. Carbonic anhydrase inhibitors: binding of indanesulfonamides to the ...

*Casuarinin

It is a highly active carbonic anhydrase inhibitor. In some plants including oak and chestnut, the ellagitannins are formed ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ...

*Carboxysome

Likewise, in some cyanobacterial strains the beta-carboxysomes contain a beta-carbonic anhydrase that is not found in the ccm ... The signature proteins of the beta-carboxysome are Form IB RuBisCO and a gamma carbonic anhydrase homolog. Beta-carboxysomes ... CsoSCA is a shell-associated beta-carbonic anhydrase. Studies in Halothiobacillus neapolitanus have shown that empty shells of ... Cannon, Gordon C.; Heinhorst, Sabine; Kerfeld, Cheryl A. (2010). "Carboxysomal carbonic anhydrases: Structure and role in ...

*Soluble adenylyl cyclase

bicarbonate derived from carbonic anhydrase (CA)-dependent hydration. CO2 metabolism Enters through membrane-transporting ... sAC inside mitochondria is activated by metabolically generated CO2 through carbonic anhydrase. Astrocytes express several sAC ...

*Reduced muscle mass, strength and performance in space

... such as carbonic anhydrase II and myoglobin, over that predicted by the overall decrease in muscle protein synthesis. In ... "Effect of immobilization on carbonic anhydrase III and myoglobin content in human leg muscle". Acta physiologica Scandinavica. ...
TY - JOUR. T1 - Biochemical and Stone-Risk Profiles With Topiramate Treatment. AU - Welch, Brian J.. AU - Graybeal, Dion. AU - Moe, Orson W.. AU - Maalouf, Naim M.. AU - Sakhaee, Khashayar. PY - 2006/10. Y1 - 2006/10. N2 - Background: Topiramate is a novel neuromodulatory agent commonly prescribed for the treatment of seizure disorders and for migraine headache prophylaxis. Calcium phosphate kidney stones have been observed with topiramate treatment, but a comprehensive elucidation of stone-risk profile was not reported previously. This study explores the relationship between topiramate treatment and propensity for kidney stone formation. Methods: Thirty-two topiramate-treated subjects and 50 healthy volunteers participated in a cross-sectional study in which serum chemistry test and 24-hour urine collection results were evaluated for stone risk. Furthermore, a short-term longitudinal study was conducted in 7 patients to assess stone risk before and 3 months after topiramate treatment. Results: ...
Bupivacaine, ropivacaine, or mepivacaine were added to human drug-free serum (pH 7.4) at a concentration of 10 μg/ml. 20% Intralipid® or 20% Lipofundin® were added at 1, 2, or 4% of the total volume because the recommended dosage of lipid bolus to treat anesthetic overdose is 1.5 ml/kg,1213 equating to approximately 3.5% of the total serum volume of the body. Multiple concentrations were used to determine the effect with respect to the volume of lipid. Once the lipid was added to the serum containing the drug, the samples were vortexed. They were then incubated at 37°C for 5 min in a water bath, and then shaken at 37°C for 5 min to ensure adequate mixing. The contents of each tube were then subjected to ultracentrifugation at room temperature using an Airfuge® at 122,000 g under 30,000 psi to separate the serum from the lipid. Serum was transferred into a fresh tube for analysis. Bupivacaine was also added at a concentration of 100 μg/ml to human drug-free serum at pH 7.4, the lipid ...
Health and wellness is a very popular topic. There are numbers of businesses, books, movies and websites dedicated to the topic. Each doctor or wellness expert has their own research and opinions on how to achieve optimum health which can be overwhelming. Good health doesnt have to mean expensive treatments and supplements, it can be…
It has been estimated that 22 - 32% of people with mental retardation or learning disability have co-existing epilepsy. Despite such high prevalence and although there may be particular concerns over the effects of treatment on behaviour and cognition in this population, few studies have specifically addressed these concerns. Topiramate (TPM) is one of the modern antiepileptic drugs that has been approved for the treatment of a broad range of seizure types in both children and adults. There is evidence of associated improvement in behaviour with treatment but data is conflicting. The investigators aim to further study the effect of TPM on seizure control and behaviour using the Scales of Independent Behavior-Revised (SIB-R) which has been applied in similar patient populations and is widely adopted locally to assess the behaviour of people with mental retardation. This is a naturalistic, open label, single arm prospective study of 16-week in duration. Eligible adult patients will be initiated on ...
An aspartate salt of L-ornithine. L-Ornithine L-aspartate has been shown to reduce blood ammonia concentrations by increasing ammonia detoxification in the liver. For use in dietary supplements, food and beverages.. ...
L-arginine is a semi-essential amino acid involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation.
TY - JOUR. T1 - The role of astrocytes in hepatic encephalopathy. AU - Norenberg, Michael D. PY - 1987/2/1. Y1 - 1987/2/1. N2 - The Alzheimer type II astrocyte change is the distinctive morphologic alteration in brain of humans and experimental animals succumbing to hepatic encephalopathy (HE). Whether this change is a primary event in the pathogenesis of HE or whether it is secondary to injury of some other component(s) of the CNS has not been clarified. Studies in a rat model of HE have revealed early reactive changes in astrocytes characterized by cytoplasmic hypertrophy. During the later phases, degenerative changes ensue corresponding to the Alzheimer type II change observed by light microscopy. In view of the role of astrocytes in ammonia detoxification and the importance of ammonia in the pathogenesis of HE, we have suggested that the initial astrocytic changes are the morphological correlates of ammonia detoxification. We have speculated that the later degenerative alterations could lead ...
The IUPHAR/BPS Guide to Pharmacology. carbonic anhydrase 9 - Carbonic anhydrases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
FUNCTIONS OF CARBONIC ANHYDRASES. The presence of carbonic anhydrases in all living organisms probably originates because the components of the catalyzed reaction are involved in almost all metabolic processes. We suppose that the main reason for the abundance of CAs in nature is the ubiquitous involvement of bicarbonate buffers in aqueous media and then in the cytoplasm at every stage of evolution; these enzymes acceleration achieving appropriate pH, which is important for homeostasis of every living cell. The role of carbonic anhydrases in accelerating the conversion of inorganic forms of carbon was probably not their initial main function, but now it is established that these enzymes are critical regulators of the exchange of these forms in many metabolic processes.. Functions of Carbonic Anhydrases in Animals. Although the main purpose of this review is to consider the available experimental data and ideas concerning the role of CAs in higher plants, we should present, at least briefly, ...
Hakvoort, T. B. M., He, Y., Kulik, W., Vermeulen, J. L. M., Duijst, S., Ruijter, J. M., ... Lamers, W. H. (2017). Pivotal Role of Glutamine Synthetase in Ammonia Detoxification. Hepatology, 65(1), 281-293. https://doi.org/10.1002/hep.28852 ...
In her first try at college-level English composition, Olga Zaldivar skipped classes, struggled through papers and ultimately abandoned the course before taking the final exam.But she figures she
CIBA has successfully demonstrated the use of bagasse as biostimulator for ammonia removal from seven different zero-exchange shrimp aquaculture systems. Bagasse is a complex native cellulosic fibrous waste left after extraction of juice from cane sugar, and an attractive agricultural byproduct for a pond supplement because of its low cost and general availability in shrimp-growing latitudes. Bagasse provides a better surface structure and nutrients beneficial for the growth of nitrifying bacteria. Bagasse is a biodegradable substrate, which harbours higher periphytic (biofilm) biomass than non degradable ones. The very low cost of this lignocellulosic material is a real advantage that renders it a suitable alternative for the remediation of ammonia. Bagasse biostimulator technology is available for adoption by the aqua-farmers. ...
Zn(2+)-dependent carbonic anhydrases (CA) catalyse the reversible hydration of carbon dioxide to bicarbonate and participate in diverse physiological processes, hence having manifold therapeutic potentials. Among the 15 human CAs with wide-ranging sub-cellular localisation and kinetic properties, CA VI is the only secretory isoform. The 1.9Å crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures. The active site cavity contains a cluster of non-conserved residues that may be involved in ligand binding and have significant implications for developing the next-generation of isoform-specific inhibitors.
Comprehensive review of visual defects reported with topiramate Lisa Ford,1 Jeffrey L Goldberg,2 Fred Selan,1 Howard E Greenberg,1 Yingqi Shi1 1Janssen Research & Development, LLC, Titusville, NJ, 2Byers Eye Institute, Stanford University, Palo Alto, CA, USA Objective: The objective of this study was to analyze clinical patterns of visual field defects (VFDs) reported with topiramate treatment and assess possible mechanism of action (MOA) for antiepileptic drug (AED) associated VFDs.Methods: A comprehensive topiramate database review included preclinical data, sponsor’s clinical trials database, postmarketing spontaneous reports, and medical literature. All treatment-emergent adverse events (TEAEs) suggestive of retinal dysfunction/damage were summarized. Relative risk (RR) was computed from topiramate double-blind, placebo-controlled trials (DBPCTs) data.Results: Preclinical studies and medical literature review suggested that despite sharing gamma-aminobutyric acid (GABA)-ergic MOA with
Sigma-Aldrich offers abstracts and full-text articles by [Vaida Morkūnaitė, Joana Gylytė, Asta Zubrienė, Lina Baranauskienė, Miglė Kišonaitė, Vilma Michailovienė, Vaida Juozapaitienė, Matthew J Todd, Daumantas Matulis].
**9.5367431640625E-7**

Carbonic anhydrase iv | Article about Carbonic anhydrase iv by The Free DictionaryCarbonic anhydrase iv | Article about Carbonic anhydrase iv by The Free Dictionary

Find out information about Carbonic anhydrase iv. An enzyme which aids carbon dioxide transport and release by catalyzing the ... synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide... Explanation of Carbonic anhydrase iv ... Related to Carbonic anhydrase iv: Carbonic anhydrase inhibitor, Carbonic anhydrase ii, carbonic anhydrase IX ... Carbonic Anhydrase. (redirected from Carbonic anhydrase iv). Also found in: Dictionary, Medical. ...
more infohttp://encyclopedia2.thefreedictionary.com/Carbonic+anhydrase+iv

Small-Molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain DiseaseSmall-Molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease

Carbonic anhydrase II deficiency syndrome or Marble brain disease (MBD) is caused by autosomal recessive mutations in the human ... We have over the past 10-15 years studied the folding, misfolding and aggregation of the enzyme human carbonic anhydrase II. In ... Small-Molecule Suppression of Misfolding of Mutated Human Carbonic Anhydrase II Linked to Marble Brain Disease. Almstedt, Karin ... Misfolding, carbonic anhydrase, prion protein, protein stability National Category Biochemistry and Molecular Biology ...
more infohttp://liu.diva-portal.org/smash/record.jsf?pid=diva2:225924

A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry...A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry...

We report here the identification of a new T. gondii carbonic anhydrase-related protein (TgCA_RP), which localizes to rhoptries ... A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry ... Carbonic anhydrase-related proteins (CARPs) have previously been described as catalytically inactive proteins closely related ... A Glycosylphosphatidylinositol-Anchored Carbonic Anhydrase-Related Protein of Toxoplasma gondii Is Important for Rhoptry ...
more infohttps://msphere.asm.org/content/2/3/e00027-17.abstract

Methazolamide Tablets, USP - Drug label and information - Rx Drugs InfoMethazolamide Tablets, USP - Drug label and information - Rx Drugs Info

Methazolamides inhibitory action on carbonic anhydrase decreases the secretion of aqueous humor and results in a decrease in ... Methazolamide is a potent inhibitor of carbonic anhydrase.. Methazolamide is well absorbed from the gastrointestinal tract. ... coma and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors (see WARNINGS). ... coma and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors. ...
more infohttp://rxdrugsinfo.com/drug-info-label/methazolamide

Carbonyl sulfide dipole momentCarbonyl sulfide dipole moment

Consumption of carbonyl sulphide (COS) by higher plant carbonic anhydrase (CA). 48D. Maryott Selected Values of electric ...
more infohttp://omega-tr.com/iorm/carbonyl-sulfide-dipole-moment.php

Methazolamide Tablet size: 50 mg at PetSmart in Hattiesburg - 70589170Methazolamide Tablet size: 50 mg at PetSmart in Hattiesburg - 70589170

The carbonic anhydrase inhibitors act by a noncompetitive, reversible inhibition of the enzyme carbonic anhydrase. This reduces ... This medication, a type of carbonic anhydrase inhibitor, works by lowering pressure in the eye, called aintraocular pressure, ... coma and death have been reported with concomitant use of high-dose aspirin and carbonic anhydrase inhibitors. Precautions: ...
more infohttp://findnsave.hattiesburgamerican.com/offer/Methazolamide-Tablet-size-50-mg/70589170/

Carbonic anhydrase 9 - WikipediaCarbonic anhydrase 9 - Wikipedia

"Entrez Gene: CA9 carbonic anhydrase IX".. *^ Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E ... Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.[5][6][7] ... Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas". Digestive and Liver Disease. 33 (1): 68-74. ... Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. ...
more infohttps://en.wikipedia.org/wiki/CA_9

Carbonic anhydrase in bacteria.  - PubMed - NCBICarbonic anhydrase in bacteria. - PubMed - NCBI

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
more infohttps://www.ncbi.nlm.nih.gov/pubmed/13996562?dopt=Abstract

Carbonic anhydrase - WikipediaCarbonic anhydrase - Wikipedia

The reaction catalyzed by carbonic anhydrase is: HCO3- + H+ ↽. −. ⇀. {\displaystyle {\ce {,=,,}}}. CO2 + H2O. Carbonic acid has ... Cadmium-containing carbonic anhydraseEdit. Marine diatoms have been found to express a new form of ζ carbonic anhydrase. T. ... Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Differences from other carbonic anhydrasesEdit. Unlike most other carbonic anhydrases, the active site metal ion is not bound ...
more infohttps://en.m.wikipedia.org/wiki/Carbonic_anhydrase

Carbonic anhydrase superfamily (IPR036874) | InterPro | EMBL-EBICarbonic anhydrase superfamily (IPR036874) | InterPro | EMBL-EBI

Carbonic anhydrase superfamily (IPR036874). Short name: Carbonic_anhydrase_sf Overlapping entries *Carbonic anhydrase ( ... Carbonic anhydrases (EC:4.2.1.1) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In ... Carbonic anhydrase in Escherichia coli. A product of the cyn operon.. J. Biol. Chem. 267 3731-4 1992 ... A gene homologous to chloroplast carbonic anhydrase (icfA) is essential to photosynthetic carbon dioxide fixation by ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR036874

Alpha carbonic anhydrase domain (IPR001148) | InterPro | EMBL-EBIAlpha carbonic anhydrase domain (IPR001148) | InterPro | EMBL-EBI

Alpha carbonic anhydrase domain (IPR001148). Short name: CA_dom Overlapping homologous superfamilies *Alpha carbonic anhydrase ... Carbonic anhydrases--an overview.. Curr. Pharm. Des. 14 603-14 2008. Smith KS, Ferry JG. Prokaryotic carbonic anhydrases.. FEMS ... A carbonic anhydrase-like domain with striking homology to that of the alpha class carbonic anhydrases is also found in ... Carbonic anhydrases (CA: EC:4.2.1.1) are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to ...
more infohttps://www.ebi.ac.uk/interpro/entry/IPR001148

Intraocular Carbonic Anhydrase Inhibitor - Trip DatabaseIntraocular Carbonic Anhydrase Inhibitor - Trip Database

Helping you find trustworthy answers on Intraocular Carbonic Anhydrase Inhibitor , Latest evidence made easy ... Find all the evidence you need on Intraocular Carbonic Anhydrase Inhibitor via the Trip Database. ... steroids, carbonic anhydrase inhibitors, or warfarin/heparin within 1 month prior to the Screening visit or anticipated use at ... If intraocular pressure is still elevated, a topical carbonic anhydrase inhibitor should be added. In patients with sickle cell ...
more infohttps://www.tripdatabase.com/search?criteria=Intraocular+Carbonic+Anhydrase+Inhibitor&page=9

Systemic carbonic anhydrase inhibitors - American Academy of OphthalmologySystemic carbonic anhydrase inhibitors - American Academy of Ophthalmology

Carbonic anhydrase inhibitors decrease aqueous production by inhibiting ion transport associated with the secretion of aqueous ... Adequate inhibition of carbonic anhydrase with systemic administration has been shown to cause a decrease in aqueous humor ... Carbonic anhydrase inhibitors decrease aqueous production by inhibiting ion transport associated with the secretion of aqueous ...
more infohttps://www.aao.org/image/systemic-carbonic-anhydrase-inhibitors

RCSB PDB - Gene View 









 - CA2 - carbonic anhydrase 2RCSB PDB - Gene View - CA2 - carbonic anhydrase 2

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
more infohttp://www.rcsb.org/pdb/gene/CA2

List of Carbonic anhydrase inhibitor anticonvulsants - Drugs.comList of Carbonic anhydrase inhibitor anticonvulsants - Drugs.com

Compare carbonic anhydrase inhibitor anticonvulsants. View important safety information, ratings, user reviews, popularity and ... Carbonic anhydrase inhibitor anticonvulsants. What are Carbonic anhydrase inhibitor anticonvulsants. Carbonic anhydrase ... inhibitor anticonvulsants inhibit the enzyme carbonic anhydrase. Generally carbonic anhydrase inhibitors are used to treat ... Home › Drug Classes › Central Nervous System Agents › Anticonvulsants › Carbonic Anhydrase Inhibitor Anticonvulsants ...
more infohttps://www.drugs.com/drug-class/carbonic-anhydrase-inhibitor-anticonvulsants.html

Carbonic Anhydrase and Zinc in Plant PhysiologyCarbonic Anhydrase and Zinc in Plant Physiology

ESCUDERO-ALMANZA, Dalila Jacqueline et al. Carbonic Anhydrase and Zinc in Plant Physiology. Chilean J. Agric. Res. [online]. ... Carbonic anhydrase (CA) (EC: 2.4.1.1) catalyzes the rapid conversion of carbon dioxide plus water into a proton and the ... Carbonic anhydrase is a metalloenzyme that requires Zn as a cofactor and is involved in diverse biological processes including ...
more infohttp://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0718-58392012000100022&lng=en&nrm=iso&tlng=en

Carbonic anhydrase, carbondioxide levels and growth of Nitrosomonas | SpringerLinkCarbonic anhydrase, carbondioxide levels and growth of Nitrosomonas | SpringerLink

Romanova AK, Rusinova NG, Kornitskaya VM (1972) Participation of carbonic anhydrase in chemosynthetic assimilation of carbonic ... Graham D (1982) Carbonic anhydrases (carbonate dehydratases) from plants. In: Mitsui A, Black CC (eds) CRC handbook of biosolar ... Hogetsu D, Miyachi S (1979) Role of carbonic anhydrase in photosynthetic CO2 fixation in Chlorella. Pl Cell Physiol 220:747-756 ... Graham D, Reed M (1971) Carbonic anhydrase and the regulation of photosynthesis. Nature (New Biol) 231:81-83Google Scholar ...
more infohttps://link.springer.com/article/10.1007/BF00454945

Anti-Carbonic Anhydrase II antibody (ab7001) | AbcamAnti-Carbonic Anhydrase II antibody (ab7001) | Abcam

Rabbit polyclonal Carbonic Anhydrase II antibody validated for WB, IP, ELISA, Conjugation, Dot and tested in Cow. Immunogen ... Anti-Carbonic Anhydrase II antibody. See all Carbonic Anhydrase II primary antibodies. ... carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic ...
more infohttps://www.abcam.com/Carbonic-Anhydrase-II-antibody-ab7001.html

Anti-Carbonic Anhydrase IX antibody (ab10471) ReferencesAnti-Carbonic Anhydrase IX antibody (ab10471) References

References for Abcams Anti-Carbonic Anhydrase IX antibody (ab10471). Please let us know if you have used this product in your ...
more infohttp://www.abcam.com/carbonic-anhydrase-ix-antibody-ab10471-references.html

Carbonic Anhydrase I from human erythrocytes | Sigma-AldrichCarbonic Anhydrase I from human erythrocytes | Sigma-Aldrich

Carbonic Anhydrase I from human erythrocytes for your research needs. Find product specific information including CAS, MSDS, ... Carbonic Anhydrase I from human erythrocytes Synonym: Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase Isozyme I ... Carbonic Anhydrase, Cell Signaling Enzymes, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Human Carbonic Anhydrase, ... Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). ...
more infohttps://www.sigmaaldrich.com/catalog/product/sigma/c4396?lang=en®ion=US

carbonic anhydrase 8 ELISA Kits | Biocompare.comcarbonic anhydrase 8 ELISA Kits | Biocompare.com

Compare carbonic anhydrase 8 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... carbonic anhydrase 8 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 19 carbonic anhydrase 8 ELISA ELISA Kit across 5 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-443705/ELISA_Kit/ELISA_carbonic_anhydrase_8

Carbonic Anhydrase IX ELISA Kits | Biocompare.comCarbonic Anhydrase IX ELISA Kits | Biocompare.com

Compare Carbonic Anhydrase IX ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews ... Carbonic Anhydrase IX ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 133 Carbonic Anhydrase IX ELISA ELISA Kit across 18 suppliers. ...
more infohttps://www.biocompare.com/pfu/110627/soids/2-4851/ELISA_Kit/ELISA_Carbonic_Anhydrase_IX

Carbonic anhydrases in anthozoan corals-A review.  - PubMed - NCBICarbonic anhydrases in anthozoan corals-A review. - PubMed - NCBI

Carbonic anhydrases in anthozoan corals-A review.. Bertucci A1, Moya A, Tambutté S, Allemand D, Supuran CT, Zoccola D. ... Carbonic anhydrases play major roles in those two essential processes of corals physiology: they are involved in the carbon ... Here, we review the current understanding of diversity and function of carbonic anhydrases in corals and discuss the ... Carbonic Anhydrase Inhibitors/chemistry. *Carbonic Anhydrase Inhibitors/metabolism. *Carbonic Anhydrases/chemistry. *Carbonic ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23199478

Frontiers | Transport metabolons with carbonic anhydrases | PhysiologyFrontiers | Transport metabolons with carbonic anhydrases | Physiology

... have been demonstrated to physically and/or functionally interact with isoforms of carbonic anhydrase (CA) to form a transport ... monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase ... Extracellular loop 4 of the human AE1 Cl−/HCO−3 exchanger binds carbonic anhydrase IV. J. Biol. Chem. 277, 25239-25246. doi: ... Not only that most of the H+ and HCO−3 carrying transporters interact with one or several isoforms of carbonic anhydrase, the ...
more infohttps://www.frontiersin.org/articles/10.3389/fphys.2013.00291/full

Carbonic anhydrase - WikipediaCarbonic anhydrase - Wikipedia

Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Carbonic anhydrase inhibitor Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant ... Carbonic\ anhydrase}}H_{2}CO_{3}}}} (in tissues - high CO2 concentration) The reaction rate of carbonic anhydrase is one of the ... The mechanism of cadmium carbonic anhydrase (CDCA) is essentially the same as that of other carbonic anhydrases in its ...
more infohttps://en.wikipedia.org/wiki/Carbonic_anhydrase
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**0.64206600189209**
  • This work suggests a new role for carbonic anhydrases (CAs) in the Aβ-induced mitochondrial toxicity associated with AD and cerebral amyloid angiopathy (CAA), and paves the way to AD clinical trials for CAIs, FDA-approved drugs with a well-known profile of brain delivery. (elsevier.com)
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