Carbonic Anhydrases
Carbonic Anhydrase Inhibitors
Benzolamide
Ethoxzolamide
Carbonic Anhydrase II
Carbonic Anhydrase III
Carbonic Anhydrase I
Isoenzymes
Acetazolamide
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Methazolamide
Psychrobacter
Antarctic Regions
Urease
Calcium, carbonic anhydrase and gastric acid secretion. (1/40)
Previous data concerning the action of calcium (Ca) on gastric acid secretion (GAS) indicated that calcium ions increase GAS elicited by gastrin released through a vagal mechanism, and also by a direct effect on parietal cells. Our research showed that the stimulating effect of calcium on gastric acid secretion can be antagonized by verapamil administration, which reduces gastric acid secretion . In the present study we followed the effect induced by administration of calcium and Ca-chelating agents (disodium EDTA) on gastric acid secretion and on carbonic anhydrase (CA) activity. We selected two groups of healthy volunteers: Group I (n=21) received a single i.v. dose of CaCl2 (15 mg/kg b.w.), whereas Group II (n=22) received a single i.v. dose of disodium EDTA (5 mg/kg b.w.). We determined blood calcium before and after treatment, gastric acid secretion at 2 hours. erythrocyte CA II activity, and CA IV activity in membrane parietal cells, which were isolated from gastric mucosa obtained by endoscopic biopsy. Assessment of carbonic anhydrase activity was achieved by the stopped-flow method. In Group I calcium administration increased blood calcium, HCl output, CA II and CA IV activity as compared to initial values. In Group II, disodium EDTA reduced blood calcium, HCl output, CA II and CA IV activity as compared to initial values. The results demonstrated that increased blood calcium and GAS values after calcium administration correlated with the increase of erythrocyte CA II and parietal cell CA IV activity, while disodium EDTA induced a reversed process. Our results also show that cytosolic CA II and membrane CA IV values are sensitive to calcium changes and they directly depend on these levels. Our data suggest that intra- and extracellular pH changes induced by carbonic anhydrase might account for the modulation of the physiological and pathological secretory processes in the organism. (+info)The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV. (2/40)
Cytosolic carbonic anhydrase II (CAII) and the cytoplasmic C-terminal tails of chloride/bicarbonate anion exchange (AE) proteins associate to form a bicarbonate transport metabolon, which maximizes the bicarbonate transport rate. To determine whether cell surface-anchored carbonic anhydrase IV (CAIV) interacts with AE proteins to accelerate the bicarbonate transport rate, AE1-mediated bicarbonate transport was monitored in transfected HEK293 cells. Expression of the inactive CAII V143Y mutant blocked the interaction between endogenous cytosolic CAII and AE1, AE2, and AE3 and inhibited their transport activity (53 +/- 3, 49 +/- 10, and 35 +/- 1% inhibition, respectively). However, in the presence of V143Y CAII, expression of CAIV restored full functional activity to AE1, AE2, and AE3 (AE1, 101 +/- 3; AE2, 85 +/- 5; AE3, 108 +/- 1%). In Triton X-100 extracts of transfected HEK293 cells, resolved by sucrose gradient ultracentrifugation, CAIV recruitment to the position of AE1 suggested a physical interaction between CAIV and AE1. Gel overlay assays showed a specific interaction between CAIV and AE1, AE2, and AE3. Glutathione S-transferase pull-down assays revealed that the interaction between CAIV and AE1 occurs on the large fourth extracellular loop of AE1. We conclude that AE1 and CAIV interact on extracellular loop 4 of AE1, forming the extracellular component of a bicarbonate transport metabolon, which accelerates the rate of AE-mediated bicarbonate transport. (+info)Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephron. (3/40)
Membrane-bound carbonic anhydrase (CA) facilitates acidification in the kidney. Although most hydratase activity is considered due to CA IV, some in the basolateral membranes could be attributed to CA XII. Indeed, CA IV is glycosylphosphatidylinositol anchored, connoting apical polarization, but CA IV immunoreactivity has been detected on basolateral membranes of proximal tubules. Herein, we determined whether CA XII mRNA was expressed in acidifying segments of the rabbit nephron. The open reading frame of CA XII was sequenced from a rabbit kidney cortex cDNA library; it was 83% identical to human CA XII and coded for a 355-amino acid single-pass transmembrane protein. Northern blot analysis revealed an abundant 4.5-kb message in kidney cortex, medulla, and colon. By in situ hybridization, CA XII mRNA was expressed by proximal convoluted and straight tubules, cortical and medullary collecting ducts, and papillary epithelium. By RT-PCR, CA XII mRNA was abundantly expressed in cortical and medullary collecting ducts and thick ascending limb of Henle's loop; it was also expressed in proximal convoluted and straight tubules but not in glomeruli or S3 segments. FLAG-CA XII of approximately 40 kDa expressed in Escherichia coli showed hydratase activity that was inhibited by 0.1 mM acetazolamide. Unlike CA IV, expressed CA XII activity was inhibited by 1% SDS, suggesting insufficient disulfide linkages to stabilize the molecule. Western blotting of expressed CA XII with two anti-rabbit CA IV peptide antibodies showed no cross-reactivity. Our findings indicate that CA XII may contribute to the membrane CA activity of proximal tubules and collecting ducts. (+info)Expression of carbonic anhydrase IV in rabbit corneal endothelial cells. (4/40)
OBJECTIVE: To demonstrate the molecular expression of carbonic anhydrase IV (CA IV) in rabbit corneal endothelium. METHODS: Reverse transcriptase polymerase chain reaction (RT-PCR) was performed using cultured and fresh rabbit corneal endothelial total RNA and specific primers for CA IV. The RT-PCR product was subcloned and sequenced. Immunoblotting and indirect immunofluorescence staining were performed to detect protein expression and distribution of CA IV using fresh and cultured rabbit corneal endothelium and rat anti-CA IV polyclonal antibody. RESULTS: RT-PCR screening gave positive bands at the predicted size for CA IV from fresh and cultured rabbit corneal endothelium. Sequencing further confirmed the identity of CA IV in corneal endothelium. Immunoblotting analysis showed a single band at 52 kDa for freshly isolated and cultured endothelial cells. Indirect immunofluorescence staining revealed an apparent positive staining in cultured endothelial cells. CONCLUSION: Carbonic anhydrase IV is expressed in rabbit corneal endothelium, which could contribute to the transendothelial HCO(3)(-) flux that is necessary to maintain corneal hydration and transparency. (+info)Immunocytochemical localization of Na+-HCO3- cotransporters and carbonic anhydrase dependence of fluid transport in corneal endothelial cells. (5/40)
In corneal endothelium, there is evidence for basolateral entry of HCO(3)(-) into corneal endothelial cells via Na(+)-HCO(3)(-) cotransporter (NBC) proteins and for net HCO(3)(-) flux from the basolateral to the apical side. However, how HCO(3)(-) exits the cells through the apical membrane is unclear. We determined that cultured corneal endothelial cells transport HCO(3)(-) similarly to fresh tissue. In addition, Cl(-) channel inhibitors decreased fluid transport by at most 16%, and inhibition of membrane-bound carbonic anhydrase IV by benzolamide or dextran-bound sulfonamide decreased fluid transport by at most 29%. Therefore, more than half of the fluid transport cannot be accounted for by anion transport through apical Cl(-) channels, CO(2) diffusion across the apical membrane, or a combination of these two mechanisms. However, immunocytochemistry using optical sectioning by confocal microscopy and cryosections revealed the presence of NBC transporters in both the basolateral and apical cell membranes of cultured bovine corneal endothelial cells and freshly isolated rabbit endothelia. This newly detected presence of an apical NBC transporter is consistent with its being the missing mechanism sought. We discuss discrepancies with other reports and provide a model that accounts for the experimental observations by assuming different stoichiometries of the NBC transport proteins at the basolateral and apical sides of the cells. Such functional differences might arise either from the expression of different isoforms or from regulatory factors affecting the stoichiometry of a single isoform. (+info)Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa. (6/40)
Genetic and physical mapping of the RP17 locus on 17q identified a 3.6-megabase candidate region that includes the gene encoding carbonic anhydrase IV (CA4), a glycosylphosphatidylinositol-anchored protein that is highly expressed in the choriocapillaris of the human eye. By sequencing candidate genes in this region, we identified a mutation that causes replacement of an arginine with a tryptophan (R14W) in the signal sequence of the CA4 gene at position -5 relative to the signal sequence cleavage site. This mutation was found to cosegregate with the disease phenotype in two large families and was not found in 36 unaffected family members or 100 controls. Expression of the mutant cDNA in COS-7 cells produced several findings, suggesting a mechanism by which the mutation can explain the autosomal dominant disease. In transfected COS-7 cells, the R14W mutation (i) reduced the steady-state level of carbonic anhydrase IV activity expressed by 28% due to a combination of decreased synthesis and accelerated turnover; (ii) led to up-regulation of immunoglobulin-binding protein, double-stranded RNA-regulated protein kinase-like ER kinase, and CCAAT/enhancer-binding protein homologous protein, markers of the unfolded protein response and endoplasmic reticulum stress; and (iii) induced apoptosis, as evidenced by annexin V binding and terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling staining, in most cells expressing the mutant, but not the WT, protein. We suggest that a high level of expression of the mutant allele in the endothelial cells of the choriocapillaris leads to apoptosis, leading in turn to ischemia in the overlying retina and producing autosomal dominant retinitis pigmentosa. (+info)Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. (7/40)
Carbonic anhydrase (CA) IV is a glycosylphosphotidylinositol-anchored enzyme highly expressed on the plasma face of microcapillaries and especially strongly expressed in the choriocapillaris of the human eye. In collaboration with scientists at the University of Cape Town (Rondebosch, South Africa), we recently showed that the R14W mutation in the signal sequence of CA IV, which they identified in patients with the retinitis pigmentosa (RP) 17 form of autosomal dominant RP, results in accumulation of unfolded protein in the endoplasmic reticulum (ER), leading to ER stress, the unfolded protein response, and apoptosis in a large fraction of transfected COS-7 cells expressing mutant, but not wild-type, CA IV. Here we present experiments showing that several well characterized CA inhibitors largely prevent the adverse effects of expressing R14W CA IV in transfected COS-7 cells. Specifically, CA inhibitors prevent the accelerated turnover of the mutant protein, the up-regulation of Ig-binding protein, double-stranded RNA-regulated protein kinase-like ER kinase, and CCAAT/enhancer-binding protein homologous protein (markers of the unfolded protein response and ER stress), the inhibition of production of other secretory proteins expressed from COS-7-transfecting plasmids, and the induction of apoptosis, all characteristics of transfected cells expressing R14W CA IV. Furthermore, treatment with 4-phenylbutyric acid, a nonspecific chemical chaperone used in other protein-folding disorders, also dramatically reduces the apoptosis-inducing effect of expressing R14W CA IV cDNA in transfected COS-7 cells. These experiments suggest a promising approach to treatment of RP17 that might delay the onset or possibly prevent this autosomal dominant form of RP. (+info)Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. (8/40)
Retina and retinal pigment epithelium (RPE) belong to the metabolically most active tissues in the human body. Efficient removal of acid load from retina and RPE is a critical function mediated by the choriocapillaris. However, the mechanism by which pH homeostasis is maintained is largely unknown. Here, we show that a functional complex of carbonic anhydrase 4 (CA4) and Na+/bicarbonate co-transporter 1 (NBC1) is specifically expressed in the choriocapillaris and that missense mutations in CA4 linked to autosomal dominant rod-cone dystrophy disrupt NBC1-mediated HCO3- transport. Our results identify a novel pathogenic pathway in which a defect in a functional complex involved in maintaining pH balances, but not expressed in retina or RPE, leads to photoreceptor degeneration. The importance of a functional CA4 for survival of photoreceptors implies that CA inhibitors, which are widely used as medications, particularly in the treatment of glaucoma, may have long-term adverse effects on vision. (+info)
Carbonic anhydrase iv | Article about Carbonic anhydrase iv by The Free Dictionary
Anti-Carbonic Anhydrase IV/CA4 antibody - C-terminal (ab85225)
Plasmidi CRISPR CA XIV | SCBT - Santa Cruz Biotechnology
CA XIV CRISPR Plasmide | SCBT - Santa Cruz Biotechnology
Wyniki wyszukiwania
पाँच मूलभूत श्रेणियाँ (Five Fundamental Categories)
Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CA IV and IX...
Article
Category:Eric XIV of Sweden - Wikimedia Commons
Обои Maximum XIV Максимум ХlV Rasch, купить в интернет-магазине
Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and...
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Carbonic anhydrases in human keratinocytes and their regulation by all-trans retinoic acid and 1α,25-dihydroxyvitamin D3 -...
Hypoxia-inducible expression of tumor-associated carbonic anhydrases. - CLAHRC
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Carbonic anhydrase 3
Carbonic Anhydrase IX / CA9 Antibody, Rabbit MAb | SinoBiological
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Carbonic anhydrase 12 - TA505571 | acris-antibodies.com
Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development
Pharmacological Inhibition of Mitochondrial Carbonic Anhydrases Protects Mouse Cerebral Pericytes from High Glucose-Induced...
Sequence Similarity
- 2FMZ: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII and XIV with L-...
HS Codes - Denmark xiv 71.08.11 - Powder
Βιοχημική και μοριακή ανάλυση της β-τύπου αφυδάτασης των δισανθρακικών του Azotobacter vinelandii
Carbonic Anhydrase and Zinc in Plant Physiology
Plus it
Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. - Sacre Anne
AID 644085 - Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using...
Alfa Aesar Carbonic Anhydrase Digest Standard, Certified Mass Spec Grade
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Lenti-Carbonic anhydrase IX (CA9) CAR (scFv-CD3ζ, G36) Viral Particle vector - Creative Biolabs
France | Facts, Geography, and History - The age of Louis XIV | Britannica.com
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Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1. - Kent Academic...
Expression of Carbonic Anhydrase IX Correlates with Histologic Grade and Metastasis in Osteosarcoma.
Functional and molecular determination of carbonic anhydrase levels in bovine and cultured human chondrocytes. - Oxford...
Anti-Carbonic Anhydrase IX antibody [SP106] (ab105226)
Rat (Rattus) Carbonic Anhydrase VII (CA7) Protein, Recombinant | ABIN6302725
Assignment of the gene determining human carbonic anhydrase, CAI, to chromosome 8, Annals of Human Genetics | 10.1111/j.1469...
Medicamente bronhodilatatoare Pagina 3
IBM XIV Storage System - Purchase - New Zealand
Carbonic anhydrase 4
"Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from ... Mahieu I, Benjamin A, Stephens R, Walters D, Carter N (1995). "Characterization of membrane bound carbonic anhydrase IV (CA IV ... "Entrez Gene: CA4 carbonic anhydrase IV". Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a ... Sender S, Decker B, Fenske CD, Sly WS, Carter ND, Gros G (1998). "Localization of carbonic anhydrase IV in rat and human heart ...
Carbonic anhydrase II
Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... Carbonic anhydrase II (gene name CA2), is one of sixteen forms of human α carbonic anhydrases. Carbonic anhydrase catalyzes ... Renal carbonic anhydrase allows the reabsorption of bicarbonate ions in the proximal tubule. Loss of carbonic anhydrase ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi ...
Carbonic anhydrase III, muscle specific
Liu C, Wei Y, Wang J, Pi L, Huang J, Wang P (Sep 2012). "Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis ... CA3 carbonic anhydrase III, muscle specific". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase ... Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene. Carbonic anhydrase III (CAIII) is a member of a ... that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible ...
Band 3 anion transport protein
... exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239-46. doi:10.1074/jbc.M202562200. PMID 11994299. Alberts, ... This is crucial for CO2 uptake by the red blood cell and conversion (by hydration catalysed by carbonic anhydrase) into a ... Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. 276 (51): 47886-94. doi: ... Vince JW, Reithmeier RA (October 1998). "Carbonic anhydrase II binds to the carboxyl terminus of human band 3, the erythrocyte ...
Anion exchange protein 3
... exchanger binds carbonic anhydrase IV". J. Biol. Chem. 277 (28): 25239-46. doi:10.1074/jbc.M202562200. PMID 11994299. ... Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers". J. Biol. Chem. 276 (51): 47886-94. doi: ... exchanger and carbonic anhydrase XIV interaction". Am. J. Physiol., Cell Physiol. 297 (5): C1091-102. doi:10.1152/ajpcell. ... Pt 4) (4): 1137-42. doi:10.1242/jcs.105.4.1137. PMID 8227202. Dudeja PK, Hafez N, Tyagi S, et al. (1999). "Expression of the ...
William S. Sly
Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi:10.1146/annurev.bi. ... Roth DE, Venta PJ, Tashian RE, Sly WS (1992). "Molecular basis of human carbonic anhydrase II deficiency". Proc. Natl. Acad. ... Sly also identified the first inherited deficiency of a human carbonic anhydrase, CA II, and defined the biochemical and ...
Topiramate
... selectively inhibits cytosolic (type II) and membrane associated (type IV) forms of carbonic anhydrase. The action ... As topiramate inhibits carbonic anhydrase, use with other inhibitors of carbonic anhydrase (e.g. acetazolamide) increases the ... Topiramate, sold under the brand name Topamax among others, is a carbonic anhydrase inhibitor medication used to treat epilepsy ... the inhibition of carbonic anhydrase may be strong enough to cause metabolic acidosis of clinical importance. The U.S. Food and ...
Electrogenic sodium bicarbonate cotransporter 1
2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter". ... 2005). "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells". J. Physiol. 559 (Pt 1): 55-65 ... 2003). "Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp986, Asp988 and kNBC1-carbonic anhydrase ... 272 (31): 19111-4. doi:10.1074/jbc.272.31.19111. PMID 9235899. Abuladze N, Lee I, Newman D, Hwang J, Boorer K, Pushkin A, Kurtz ...
Carbonic anhydrase inhibitor
... particularly subtypes II and IV. Whether carbonic anhydrase inhibition contributes to its clinical activity is not known. In ... Carbonic anhydrase inhibitors are a class of pharmaceuticals that suppress the activity of carbonic anhydrase. Their clinical ... are carbonic anhydrase inhibitors. Supuran CT, Scozzafava A, Conway J, eds. (2004). Carbonic anhydrase: its inhibitors and ... "Carbonic Anhydrase Inhibitors and High Altitude Illnesses". In Frost, Susan C.; McKenna, Robert (eds.). Carbonic Anhydrase: ...
Carbonic anhydrase 13
... is a protein that in humans is encoded by the CA13 gene. Carbonic anhydrases (CAs) are a family of zinc ... "Entrez Gene: Carbonic anhydrase 13". Retrieved 2019-12-31. Badger MR, Price GD (1994). "The role of carbonic anhydrase in ... Overview of all the structural information available in the PDB for UniProt: Q8N1Q1 (Human Carbonic anhydrase 13) at the PDBe- ... January 2004). "Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family". The Journal of ...
Carbonic anhydrase VI
Carbonic anhydrase 6 is an enzyme that in humans is encoded by the CA6 gene. It is also called 'gustin' because of its presence ... "Entrez Gene: CA6 carbonic anhydrase VI". Henkin RI, Mueller CW, Wolf RO (July 1975). "Estimation of zinc concentration of ... The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary ... Aldred P, Fu P, Barrett G, Penschow JD, Wright RD, Coghlan JP, Fernley RT (January 1991). "Human secreted carbonic anhydrase: ...
Carbonic anhydrase 12
... is an enzyme that in humans is encoded by the CA12 gene. Carbonic anhydrases (CAs) are a large family of ... "Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is ... "Entrez Gene: CA12 carbonic anhydrase XII". Feldshtein, M; Elkrinawi, S; Yerushalmi, B; Marcus, B; Vullo, D; Romi, H; Ofir, R; ... Tarun AS, Bryant B, Zhai W, Solomon C, Shusterman D (2004). "Gene expression for carbonic anhydrase isoenzymes in human nasal ...
Carbonic anhydrase
CA-IV, CA-IX, CA-XII, CA-XIV and CA-XV) (CA4, CA9, CA12, CA14) There are three additional "acatalytic" human carbonic anhydrase ... Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Carbonic anhydrase inhibitor Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant ... Carbonic anhydrase could in principle prove relevant to carbon capture. Some carbonic anhydrases can withstand temperatures up ...
Carbonic anhydrase 9
"Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate ... Carbonic anhydrase IX (CA9/CA IX) is an enzyme that in humans is encoded by the CA9 gene. It is one of the 14 carbonic ... "Carbonic anhydrase IX as an imaging and therapeutic target for tumors and metastases". Sub-Cellular Biochemistry. Carbonic ... "Entrez Gene: CA9 carbonic anhydrase IX". Morgan PE, Pastoreková S, Stuart-Tilley AK, Alper SL, Casey JR (August 2007). " ...
Carbonic anhydrase 7
"Entrez Gene: CA7 carbonic anhydrase VII". Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies ... Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene. Carbonic anhydrases are a large family of ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7 v t e ( ... Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors ...
ITPR1
Hirota J, Ando H, Hamada K, Mikoshiba K (Jun 2003). "Carbonic anhydrase-related protein is a novel binding protein for inositol ... Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to ... 21 (4): 717-26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554. Kiselyov K, Xu X, Mozhayeva G, Kuo T, Pessah I ... 4 (1): 57-64. doi:10.2174/157016206775197583. PMID 16454711. Joseph SK, Lin C, Pierson S, Thomas AP, Maranto AR (Oct 1995). " ...
Carbonic anhydrase 14
... is an enzyme that in humans is encoded by the CA14 gene. Carbonic anhydrases (CAs) are a large family of ... "Entrez Gene: CA14 carbonic anhydrase XIV". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified ... 2002). "Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification". Kidney Int. 61 (6): 2111-8. doi: ... Fujikawa-Adachi K, Nishimori I, Taguchi T, Onishi S (Nov 1999). "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA ...
Carbonic anhydrase 5B, mitochondrial
... is an enzyme that in humans is encoded by the CA5B gene. Carbonic anhydrases (CAs) are a ... Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64: 375-401. doi: ... "Entrez Gene: CA5B carbonic anhydrase VB, mitochondrial". Human CA5B genome location and CA5B gene details page in the UCSC ... 2007). "Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and ...
CA8
... continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase ... Carbonic anhydrase-related protein is a protein that in humans is encoded by the CA8 gene. The CA8 protein lacks the catalytic ... Bergenhem NC, Sait SS, Eddy RL, Shows TB, Tashian RE (1995). "Assignment of the gene for human carbonic anhydrase VIII(CA8) to ... "Entrez Gene: CA8 carbonic anhydrase VIII". UniProt accession number: P35219; Retrieved 27 December 2019 Online Mendelian ...
CA4
Carbonic anhydrase 4, an enzyme that in humans is encoded by the CA4 gene Cornu Ammonis region 4, a region of the hippocampus ... 4 atoms of Calcium Ca.4 may refer to: Caproni Ca.4, an Italian heavy bomber of the World War I era This disambiguation page ... CAC CA-4, a 1941 Australian bomber aircraft USS Pittsburgh (CA-4), a 1901 United States Navy armored cruiser California's 4th ... and Nicaragua Combretastatin A-4, a natural polyphenol Ca4 may refer to: Ca4 line, a regional Catalonia railway line connecting ...
Prosthetic group
... for example in carbonic anhydrase), copper (for example in complex IV of the respiratory chain) and molybdenum (for example in ... 4 (3): 217-29. doi:10.2174/1389203033487199. PMID 12769720. Banerjee R, Ragsdale SW (2003). "The many faces of vitamin B12: ... 280 (5725): 843-4. Bibcode:1979Natur.280..843S. doi:10.1038/280843a0. PMID 471057. S2CID 3094647.{{cite journal}}: CS1 maint: ...
Carbon dioxide
10.329 In organisms carbonic acid production is catalysed by the enzyme, carbonic anhydrase. CO2 is a potent electrophile ... As a linear triatomic molecule, CO2 has four vibrational modes as shown in the diagram. In the symmetric and the antisymmetric ... Carbonic anhydrase 4 converts to carbonic acid leading to a sour taste, and also the dissolved carbon dioxide induces a ... 3 by the enzyme carbonic anhydrase in the red blood cells, by the reaction CO2 + H2O → H2CO3 → H+ + HCO−3. 5-10% is dissolved ...
Sally-Ann Poulsen
"Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases". ... "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors". Journal of the American ... During her bachelor's degree she started to study pyrazolo [3,4-d] pyrimidines. As an undergraduate student, Poulsen was part ... Poulsen, Sally-Ann (1992). Synthesis and structure-activity studies of pyrazolo[3,4-d]pyrimidines binding to adenosine ...
Cecilia Lutwak-Mann
Davenport, Horace W. (1 June 1984). "The Early Days of Research on Carbonic Anhydrase" (PDF). Annals of the New York Academy of ... Lutwak-Mann was known for discovering that the hormone progesterone acts on the placenta to control carbonic anhydrase ... Davenport, Horace W. (1 April 1980). "Carbonic Anhydrase, or the Strange Case of the Disappearing Scientist". The Physiologist ... 429 (1): 4-9. Bibcode:1984NYASA.429....4D. doi:10.1111/j.1749-6632.1984.tb12310.x. hdl:2027.42/73862. ISSN 1749-6632. PMID ...
Holoprotein
An example of an enzyme that contains a cofactor is carbonic anhydrase, which has a zinc cofactor bound as part of its active ... "Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase ... 44 (4): 1097-115. doi:10.1021/bi0480279. PMID 15667203. Stryer L, Berg JM, Tymoczko JL (2002). Biochemistry (5th ed.). San ...
CA1 (gene)
Carbonic anhydrase 1 is an enzyme that in humans is encoded by the CA1 gene. Carbonic anhydrases (CAs) are a large family of ... "Entrez Gene: CA1 carbonic anhydrase I". "CA1 - Carbonic anhydrase 1 - Homo sapiens (Human) - CA1 gene & protein". www.uniprot. ... The reaction catalyzed by CA1 is the same as other carbonic anhydrase family proteins: CO 2 + H 2 O → Carbonic anhydrase H 2 CO ... Lin KT, Deutsch HF (Mar 1973). "Human carbonic anhydrases. XI. The complete primary structure of carbonic anhydrase B". The ...
Polycoria
... and carbonic anhydrase inhibitors. Antibiotics and steroid drops for 4 weeks post surgery. Complications of surgical procedures ...
4-Nitrophenol
... for carbonic anhydrase), 4-nitrophenyl-β-D-glucopyranoside and other sugar derivatives which are used to assay various ... 4-Nitrophenol can be used as a pH indicator. A solution of 4-nitrophenol appears colorless below pH 5.4 and yellow above pH 7.5 ... In solution, 4-nitrophenol has a dissociation constant (pKa) of 7.15 at 25 °C. 4-Nitrophenol can be prepared by nitration of ... Amounts of 4-nitrophenol produced by a particular enzyme in the presence of its corresponding substrate can be measured with a ...
John Tileston Edsall
Rickli, E E; Edsall, J. T.; Ghazanfar, A S S; Gibbons, B H (1964). "Carbonic anhydrases from human erythrocytes". J. Biol. Chem ... and carbonic anhydrase. In 1944 John Edsall was a founding co-editor of the journal Advances in Protein Chemistry. He was ... 239 (4): 1065-1078. doi:10.1016/S0021-9258(18)91392-X. Klotz, I.M. (2003). "John T. Edsall: an appreciation". Biophysical ... doi:10.1016/S0301-4622(02)00259-4. PMID 12646346. "A tribute to John T. Edsall. Editor 1958-1967". Journal of Biological ...
Ethoxzolamide
It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also ... Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport ... Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water ... Dimazole Dithiazanine iodide Gordon DM (July 1958). "Ethoxzolamide; a new carbonic anhydrase inhibitor". American Journal of ...
List of diseases (C)
Carbohydrate deficient glycoprotein syndrome Carbon baby syndrome Carbonic anhydrase II deficiency Carcinoid syndrome Carcinoma ... monosomy 4q Chromosome 4, monosomy 4q32 Chromosome 4, monosomy distal 4q Chromosome 4, partial trisomy distal 4q Chromosome 4, ... Trisomy 4p Chromosome 4, trisomy 4q Chromosome 4, trisomy 4q21 Chromosome 4, trisomy 4q25 qter Chromosome 5, monosomy 5q35 ... Trisomy 3q2 Chromosome 4 - Chromosome 5 Chromosome 4 ring Chromosome 4 short arm deletion Chromosome 4, monosomy 4p14 p16 ...
Progestogen ester
"Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase as indicator of luteoid potency: ... In the Clauberg bioassay the 3β-hydroxy-4-pregnen-20-one shows about the same potency as progesterone (34). In regard to the ... 74 (4): 533-536. doi:10.1111/j.1471-0528.1967.tb03986.x. PMID 5340429. S2CID 31602503. Charman, William N.; Porter, Christopher ...
Biometal (biology)
... for the need of zinc in human cells was shown until the late 1930s where its presence was demonstrated in carbonic anhydrase ... 14 (4): 7370-7390. doi:10.3390/ijms14047370. PMC 3645691. PMID 23549270. Yamori M, Njelekela M, Mtabaji J, Yamori Y, Bessho K ( ... ISBN 978-94-007-5560-4. Aggett PJ (August 1985). "Physiology and metabolism of essential trace elements: an outline". Clinics ...
Physiological effects in space
... such as carbonic anhydrase II and myoglobin, over that predicted by the overall decrease in muscle protein synthesis. In ... Four rubber bungee cords provided an equivalent weight of about 80 kilograms (175 lbs) and were attached to a shoulder and ... "Effect of immobilization on carbonic anhydrase III and myoglobin content in human leg muscle". Acta Physiologica Scandinavica. ... Despite four decades of effort, success in prevention of spaceflight muscle atrophy and skeletal muscle functional deficits has ...
Loop diuretic
Thiazide (blockade of sodium-chloride symporter), amiloride (blockade of epithelial sodium channels) and carbonic anhydrase ... Rachoin, Jean-Sebastien; Elizabeth A. Cerceo (2011). "Four nephrology myths debunked". Journal of Hospital Medicine. 6 (5): -1- ... Pulmonary edema - Slow intravenous bolus dose of 40 to 80 mg furosemide at 4 mg per minute is indicated for patients with fluid ... ISBN 978-0-9578521-4-3. Rho, YH; Zhu, Y; Zhang, Y; Reginato, AM; Choi, HK (2012). "Risk factors for pseudogout in the general ...
Winifred Ashby
She also contributed many studies of the carbonic anhydrase activity of the central nervous system. Women of Mayo Clinic Laura ... ISBN 978-1-85070-333-4. The Houghton Mifflin Dictionary of Biography. Houghton Mifflin Harcourt, 2003, page 72. ISBN 978-0-618- ...
Glaucoma
Carbonic anhydrase inhibitors decrease bicarbonate formation from ciliary processes in the eye, thus decreasing the formation ... The relative risk of having primary open-angle glaucoma (POAG) is increased about two- to four-fold for people who have a ... Carbonic anhydrase inhibitors, such as dorzolamide, brinzolamide, and acetazolamide, lower secretion of aqueous humor by ... carbonic anhydrase inhibitors in the mid-1990s.. Early surgical techniques like iridectomy and fistulating methods have ...
Zinc in biology
In vertebrate blood, carbonic anhydrase converts CO 2 into bicarbonate and the same enzyme transforms the bicarbonate back into ... Each of the nine or ten Zn2+ ions in a zinc finger helps maintain the finger's structure by coordinately binding to four amino ... The non-related β-carbonic anhydrase is required in plants for leaf formation, the synthesis of indole acetic acid (auxin) and ... Two examples of zinc-containing enzymes are carbonic anhydrase and carboxypeptidase, which are vital to the processes of carbon ...
Metformin
... carbonic anhydrase inhibitors such as topiramate), surgery, and other procedures, or in people having a radiological study with ... March 2022). "Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis". ... complex IV-mediated inhibition of the GPD2 variant of mitochondrial glycerol-3-phosphate dehydrogenase (thereby reducing ... 162 (4): 484-5. doi:10.1001/archinte.162.4.484. PMID 11863489. de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets ...
Cyanase
... a combined application of cyanase and carbonic anhydrase has been used in a study. Qian D, Jiang L, Lu L, Wei C, Li Y (March ... The active site of the enzyme is located between dimers and is composed of residues from four adjacent subunits of the ... 7 (3-4): 247-52. doi:10.1111/j.1574-6968.1990.tb04920.x. PMID 2094285. Chin CC, Anderson PM, Wold F (January 1983). "The amino ... 262 (19): 9021-5. doi:10.1016/S0021-9258(18)48040-4. PMID 3110153. Walsh MA, Otwinowski Z, Perrakis A, Anderson PM, Joachimiak ...
Hydroflumethiazide
Carbonic anhydrase inhibitors, All stub articles, Cardiovascular system drug stubs). ... Novello FC, Bell SC, Abrams EL, Ziegler C, Sprague JM (1960). "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of ... I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society. 82 (5 ...
Seagrass
Towards a model for inorganic carbon uptake in seagrasses involving carbonic anhydrase. In Kuo J, Phillips RC, Walker DI, ... The APG IV system and The Plant List Webpage do not share this family assignment. Seagrass populations are currently threatened ... Seagrasses are a paraphyletic group of marine angiosperms which evolved in parallel three to four times from land plants back ... "An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG IV". Botanical ...
Acid-base homeostasis
3 through the action of carbonic anhydrase. When the extracellular fluids tend towards acidity, the renal tubular cells secrete ... There are therefore four different acid-base problems: metabolic acidosis, respiratory acidosis, metabolic alkalosis, and ... H2CO3] is the molar concentration of carbonic acid in the extracellular fluid. However, since the carbonic acid concentration ... There, carbonic acid spontaneously dissociates into hydrogen ions and bicarbonate ions. When the pH in the ECF falls, hydrogen ...
Streptomyces sioyaensis
ISBN 0-08-086577-1. editors, Susan C. Frost, Robert McKenna (2014). Carbonic Anhydrase: Mechanism, Regulation, Links to Disease ... 148 (Pt 4): 1151-9. doi:10.1099/00221287-148-4-1151. PMID 11932459. Kawanami, Jun'Ichi; Kimura, Akira; Nakagawa, Yuzo; Otsuka, ... ISBN 0-8493-6927-4. {{cite book}}: ,first1= has generic name (help) Baker, edited by James B. McClintock, Bill J. (2001). ...
CA11
Carbonic anhydrase-related protein 11 is a protein that in humans is encoded by the CA11 gene. Carbonic anhydrases (CAs) are a ... "Entrez Gene: CA11 carbonic anhydrase XI". Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, Wincovitch S, Garfield S, Conze D, El- ... Bellingham J, Gregory-Evans K, Gregory-Evans CY (1998). "Sequence and tissue expression of a novel human carbonic anhydrase- ... Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S (2001). "cDNA sequence of human carbonic anhydrase-related ...
Sodium-hydrogen antiporter 1
... has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the ... Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L (September 2002). "Carbonic anhydrase II binds to and enhances activity of ... 16 (4): 365-72. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280. S2CID 25616109. Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, ...
Chloride anion exchanger
"The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II". American Journal ... 4 (8): 1857-63. PMID 9717812. Höglund P, Auranen M, Socha J, Popinska K, Nazer H, Rajaram U, Al Sanie A, Al-Ghanim M, Holmberg ... 11 (4): 321-7. doi:10.1002/(SICI)1098-1004(1998)11:4. 3.0.CO;2-A. PMID 9554749. S2CID 39309679. Antalis TM, Reeder JA, Gotley ... 81 (4): 1499-533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862. Mäkelä S, Kere J, Holmberg C, Höglund P ( ...
Hydrophobic effect
"The binding of benzoarylsulfonamide ligands to human carbonic anhydrase is insensitive to formal fluorination of the ligand". ... and translational motion of the water molecules in the solvation shell may be restricted by a factor of two to four; thus, at ... 99 (4): 629-644. Bibcode:1982JThBi..99..629C. doi:10.1016/0022-5193(82)90191-6. PMID 7183857. Lockett MR, Lange H, Breiten B, ... 9 (4): 264-70. doi:10.1038/nchembio.1181. PMC 5521822. PMID 23396077. (Articles with short description, Short description ...
Saliva
... secretes carbonic anhydrase (gustin), which is thought to play a role in the development of taste buds. Saliva contains ... Basic reproduction number Spittle cures Nosek, Thomas M. Essentials of Human Physiology, Section 6, Chapter 4. Archived from ...
PTPRZ1
... an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein ... is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. ... 32 (3): 411-4. doi:10.1038/ng1004. PMID 12355066. S2CID 19800079. Müller S, Kunkel P, Lamszus K, Ulbricht U, Lorente GA, Nelson ... 46 (3): 491-4. doi:10.1006/geno.1997.5051. PMID 9441757. Onyango P, Lubyova B, Gardellin P, Kurzbauer R, Weith A (1998). " ...
Transition metal imidazole complex
Examples include myoglobin (Fe), carbonic anhydrase (Zn), azurin (Cu), and alpha-ketoglutarate-dependent hydroxylases (Fe). ... 4". Acta Chemica Scandinavica. 26: 3005-3020. doi:10.3891/acta.chem.scand.26-3005. Banerjee, Rahul; Furukawa, Hiroyasu; Britt, ...
Diffusion-limited enzyme
Koenig, Seymour H.; Brown, Rodney D. (1972). "H2CO3 as Substrate for Carbonic Anhydrase in the Dehydration of HCO3−". ... "CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2" (PDF). Angewandte Chemie International Edition ... it was observed that in the dehydration of H2CO3 catalyzed by carbonic anhydrase, the second-order rate constant obtained ... Acetylcholinesterase β-lactamase Catalase Carbonic anhydrase Carbon monoxide dehydrogenase Cytochrome c peroxidase Fumarase ...
Etacrynic acid
Carbonic anhydrase inhibitors, World Anti-Doping Agency prohibited substances, Vinylidene compounds). ... 16 (1): 102-4. doi:10.1097/MJT.0b013e3181961264. PMID 19142157. Merck and FDA Etacrynic acid Label. Last updated February 2005 ...
Primary polydipsia
... a carbonic anhydrase inhibitor Lithium was previously used for treatment of PPD as a direct competitive ADH antagonist, but is ... 18 (4): 272-281. doi:10.1016/S0893-133X(97)00159-0. ISSN 0893-133X. PMID 9509495. Shevitz, S. A.; Jameison, R. C.; Petrie, W. M ... 29 (4): 548-9. doi:10.1136/gut.29.4.548. PMC 1433532. PMID 3371724. Falk, John L. (1969-05-01). "Conditions Producing ... 168 (4): 246-248. doi:10.1097/00005053-198004000-00011. ISSN 0022-3018. PMID 7365485. Douglas, Ivor (2006-09-01). "Hyponatremia ...
Ioan Pușcaș
In the 1970s, he proposed the use of carbonic anhydrase (CA) inhibitor acetazolamide to heal peptic ulcers. In 1962, he became ... Treatment of Gastroduodenal Ulcers with Carbonic Anhydrase Inhibitors, Annals of the New York Academy of Sciences, Volume 429 ( ... Ioan Puşcaş (10 July 1932 - 4 April 2015) was a Romanian gastroenterologist, born in Treznea, Sălaj. ...
Bumetanide
Carbonic anhydrase inhibitors, NMDA receptor antagonists, World Anti-Doping Agency prohibited substances, Anilines). ... It 2008, ESPN reported that four NFL players were being suspended under the steroid policy as a result of taking bumetanide. It ... 26 (4): 551-557. doi:10.1592/phco.26.4.551. ISSN 0277-0008. PMID 16553515. S2CID 21612858. Tornero, P.; de Barrio, M.; Baeza, M ... 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives". Journal of Medicinal Chemistry. 14 (5): 432-9. doi:10.1021/ ...
Carbon disulfide hydrolase
The enzyme is similar to that of carbonic anhydrases. The enzyme monomer of CS2 hydrolase displays a typical β-carbonic ... Four dimers form a square octameric ring through interactions of the long arms at the N and C termini. Similar ring structures ... The process is similar to the hydration of CO2 by carbonic anhydrase. This similarity points to a likely mechanism. The zinc at ... This provides a key difference between carbonic anhydrase and CS2 hydrolase. This tunnel determines the enzyme's substrate ...
Human CA4(Carbonic Anhydrase IV) ELISA Kit - SISMeNC - SIstemi Sanitari, Medicine Tradizionali e Non Convenzionali
Human CA4(Carbonic Anhydrase IV) ELISA Kit. Human CA4(Carbonic Anhydrase IV) ELISA Kit. To Order Contact us below: ... Description: A sandwich ELISA kit for detection of Carbonic Anhydrase IV from Human in samples from blood, serum, plasma, cell ... Description: A sandwich CLIA kit for quantitative measurement of Human CA4 (Carbonic Anhydrase IV) in samples from Serum, ... Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Carbonic Anhydrase IV ( ...
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura...
... prepared by palladium nanoparticle-catalyzed Suzuki-Miyaura cross-coupling reactions and evaluated as human carbonic anhydrase ... 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd 4-Arylbenzenesulfonamides as Human ... Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X- ... on the activity/selectivity were rationalized by means of X-ray crystallography of the adducts of hCA II with several 4- ...
Zinc in PDB 4rfc: Human Carbonic Anhydrase II in Complex with Tert-Butyl 4-(4- Sulfamoylphenoxy)Butylcarbamate
Human Carbonic Anhydrase II in Complex with Tert-Butyl 4-(4- Sulfamoylphenoxy)Butylcarbamate ... A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Carbonic Anhydrase II in Complex with ... In total only one binding site of Zinc was determined in the Human Carbonic Anhydrase II in Complex with Tert-Butyl 4-(4- ... The structure of Human Carbonic Anhydrase II in Complex with Tert-Butyl 4-(4- Sulfamoylphenoxy)Butylcarbamate, PDB code: 4rfc ...
Migraine Headache Medication: Serotonin 5-HT1F Agonists (Ditans), Serotonin 5-HT-Receptor Agonists (Triptans), Ergot...
Inhibition of carbonic anhydrase, particularly isozymes II and IV. Previous Next: Antihistamines, 1st Generation. Class Summary ... First IV GCRP monoclonal antibody approved for prevention of migraine. It is administered every 3 months. ... 4] Opioids should not be used long-term, because they are habit-forming. Also, they can contribute to rebound headaches. A ... Pain relief is experienced by 60-68% of patients within 4 hours of treatment and maintained for up to 24 hours in 49-67% of ...
PDB 6RG3 | Chain CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (R)- 4-(2-BENZYLPIPERAZIN-1-YL...
CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (R)- 4-(2-BENZYLPIPERAZIN-1-YL)BENZENESULFONAMIDE - 6RG3 , ... CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (R)- 4-(2-BENZYLPIPERAZIN-1-YL)BENZENESULFONAMIDE ... CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (R)- 4-(2-BENZYLPIPERAZIN-1-YL)BENZENESULFONAMIDE ...
Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors:...
Carbonic Anhydrase VII (196 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 151-168.. Impact Factor: 0. View ... Carbonic Anhydrases: An Overview (216 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 3-13.. Impact Factor: 0. ... Carbonic Anhydrase II as Target for Drug Design (245 views). Carbonic Anhydrases As Biocatalysts, 2015 Jan 08; N/D: 51-90.. ... IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors. ▼ Carbonic Anhydrase family as target for rational ...
MPD: Genomic feature: Car4
Methanosaeta thermophila - microbewiki
The carbonic anhydrase(abbreviated CA) from acetate-grown Methanosaeta thermophila was purified. The molecular mass of the ... and four other phylogenetically divergent microbes revealed high identity which included five glutamates," (9). These ... 3) Carbonic anhydrase is an ancient enzyme widespread in prokaryotes. Smith KS, Jakubzick C, Whittam TS, Ferry JG. Proc Natl ... A carbonic anhydrase from the archaeon Methanosarcina thermophila. Alber BE, Ferry JG. Proc Natl Acad Sci U S A. 1994 Jul 19; ...
GABAA Receptors | GABAA and GABAA-ρ Receptors | Tocris Bioscience
Quinethazone: Uses, Interactions, Mechanism of Action | DrugBank Online
Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for ... Supuran CT: Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides. Curr Pharm Des. ... Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited--old leads for ... Supuran CT: Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides. Curr Pharm Des. ...
Plus it
K. M. Scott - Google Scholar
Glaucoma in Small Animals - Emergency Medicine and Critical Care - MSD Veterinary Manual
Corneoscleral Laceration Medication: Antibiotics, Carbonic anhydrase inhibitors, Anticholinergic agents, Corticosteroids
Topoisomerase IV plays a key role in chromosomal DNA portioning during bacterial cell division. ... Carbonic anhydrase inhibitors. Class Summary. These agents are used to treat elevation of intraocular pressure associated with ... Inhibits enzyme carbonic anhydrase, reducing rate of aqueous humor formation, which, in turn, reduces intraocular pressure. ... it may inhibit the enzyme carbonic anhydrase in the ciliary processes of the eye. This effect decreases aqueous humor secretion ...
Trace and Macro Elements Concentrations in Selected Fresh Fruits, Vegetables, Herbs, and Processed Foods in North Carolina, USA
A total of 49 food samples comprising of 16 difference fresh fruits, 17 fresh vegetables, 4 herbs, and 12 processed foods were ... and carbonic anhydrase [4] [6] . Copper (Cu) is required for redox enzymes cytochrome oxidase [4] [7] [8] . Iron (Fe) is also a ... 4. Conclusion. The concentrations of essential and potentially toxic elements in fresh fruits, vegetables, fresh herbs, and pro ... A total of 49 food samples comprising of 16 fresh fruits, 17 fresh vegetables, 4 herbs, and 12 processed foods shown in Table 1 ...
Frontiers | Complete Genome Sequence of Carbonic Anhydrase Producing Psychrobacter sp. SHUES1
... urease and carbonic anhydrase, that play an important role in the MICP process. The role of carbonic anydrase (EC 4.2.1.1) in ... This bacterium produced lipase and protease at 4°C in a plate assay. The ability of Psychrobacter sp. to show extracellular ... Complete Genome Sequence of Carbonic Anhydrase Producing Psychrobacter sp. SHUES1 ... SHUES1 was the presence of carbonic anhydrase gene in it. Carbonic anhydrase participates in all physiological processes ...
RCSB PDB - 6SDT: HUMAN CARBONIC ANHYDRASE VII IN COMPLEX WITH A SULFONAMIDE INHIBITOR
HUMAN CARBONIC ANHYDRASE VII IN COMPLEX WITH A SULFONAMIDE INHIBITOR ... Carbonic anhydrase 7. A. 274. Homo sapiens. Mutation(s): 2 Gene Names: CA7. EC: 4.2.1.1. ... Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII are implicated in neuronal excitation, seizures, and neuropathic ... Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII are implicated in neuronal excitation, seizures, and neuropathic ...
Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease | Pharmacological Reviews
... carbonic anhydrase II/IX; GLUT, glucose transporter; H+, proton; LDH, lactate dehydrogenase. Adapted from Noor et al., 2018. ... IV. Substrates and Inhibitors. *V. Regulation and Development. *VI. Monocarboxylate Transporters in Health and Disease ... MCT3 and 4. Wounded RPE results in a decrease in expression of MCT3, and an increase in the expression of MCT4. Gallagher- ... MCT1, 2, 4. High expression in many cancer types, including breast, bone, colon, bladder, prostate, and renal cancers. Park et ...
Recombinant Human Glutamate Receptor 4 GST (N-Term) Protein (H00002893-P01): Novus Biologicals
Recombinant Human Glutamate Receptor 4 GST (N-Term) Protein. Backed by our 100% Guarantee. ... Recombinant Human Glutamate Receptor 4 GST (N-Term) Protein Summary. Description. A recombinant protein with GST tag at N- ... Be the first to review our Recombinant Human Glutamate Receptor 4 GST (N-Term) Protein and receive a gift card or discount.. ... Blogs on Glutamate Receptor 4. There are no specific blogs for Glutamate Receptor 4, but you can read our latest blog posts. ...
Comparatively Speaking: Cofactors vs. Coenzymes | Cosmetics & Toiletries
An example of an enzyme that contains a cofactor is carbonic anhydrase, which has a zinc cofactor bound as part of its active ... Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase ... II, Biochemistry 44 (4) 1097-115 (2005) 3. AL Wagner, Vitamins and Coenzymes, Krieger Publishing Co. (1975) ...
DNA Polymerase Beta/POLB Recombinant Protein (RPES2462)
Profile | Biosciences | University of Exeter
Wilson, R.W. & Grosell, M (2002). The critical role of carbonic anhydrase in calcium homeostasis and water absorption in marine ... During stages I-V, growth was measured on 1, 6, 11, 18, 24, and 31dph (days post hatch), and survival was measured on 1, 18, 24 ... secretion is fueled by endogenous epithelial CO2 hydration mediated by carbonic anhydrase because acetazolamide (10-4 M) was ... secretion is fueled by endogenous epithelial CO2 hydration mediated by carbonic anhydrase because acetazolamide (10-4 M) was ...
GSE13485 PRE VS POST YF17D VACCINATION PBMC UP
Pesquisa | Portal Regional da BVS
Considering the downsides of multidrug therapies and the relevance of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrases ... Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents ... The obtained compound 12 shows a satisfactory DPP IV inhibition with a good selectivity CA profile (DPP IV IC50: 0.0490 µM; CA ... Diabetes Mellitus Tipo 2 , Inibidores da Dipeptidil Peptidase IV , Masculino , Humanos , Inibidores da Dipeptidil Peptidase IV/ ...
carbonic anhydrase catalyzes what reaction
The enzyme carbonic anhydrase catalyzes the reaction CO2(g)+H2O(l)HCO3-(aq)+H+(aq). Carbonic anhydrase, enzyme found in red ... Which reaction is catalyzed by carbonic anhydrase? The enzyme carbonic anhydrase catalyzes the reaction CO2(g)+H2O(l)HCO3-( ... Carbonic anhydrase is the enzyme that catalyzes the chemical reaction that makes carbonic acid (H2CO3). Hydrase is related to ... carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating ...
CoP: Co-expressed Biological Processes
DeCS
Carbonic Anhydrase IV - Preferred Concept UI. M0389743. Scope note. A membrane-bound carbonic anhydrase found in lung ... A membrane-bound carbonic anhydrase found in lung capillaries and kidney.. Annotation:. /antag: coord with CARBONIC ANHYDRASE ... Carbonic Anhydrase Isozyme IV. Tree number(s):. D08.811.520.241.300.150.400. D12.776.395.550.448.160. D12.776.543.484.500.160. ... Carbonic anhydrase-IV Entry term(s):. Anhydrase 4, Carbonic. Carbonic Anhydrase 4. ...
CSGI - Publications
Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl ... Carbonic Anhydrase Inhibition Activities of Schiffs Bases Based on Quinazoline-Linked Benzenesulfonamide ... Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase ... a novel class of human and bacterial carbonic anhydrase inhibitors. - Abdoli M. - Bonardi A. - Claudiu Supuran - Žalubovskis R. ...
Carbonic anhydrase VA deficiency: MedlinePlus Genetics
Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes of metabolic crisis abnormal brain function ... The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes ... Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401. doi: 10.1146/annurev.bi. ... Hyperammonemia due to carbonic anhydrase VA deficiency. *Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency ...
Inhibitors10
- 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. (bvsalud.org)
- Benzenesulfonamides bearing various substituted (hetero)aryl rings in the para-position were prepared by palladium nanoparticle -catalyzed Suzuki-Miyaura cross-coupling reactions and evaluated as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors against isoforms hCA I, II, IX, and XII. (bvsalud.org)
- latanoprost), systemic mannitol (1-2 g/kg, IV), and topical or systemic carbonic anhydrase inhibitors. (msdvetmanual.com)
- METHODS: Conducted a retrospective cohort analysis in adults with type 2 diabetes (T2DM) for associations between metformin use and COVID-19 outcomes with an active comparator design of prevalent users of therapeutically equivalent diabetes monotherapy: metformin versus dipeptidyl-peptidase-4-inhibitors (DPP4i) and sulfonylureas (SU). (bvsalud.org)
- Supuran, C.T. Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors. (studyinindia.gov.in)
- 1 , 2 Treatment options for CME vary and include anti-vascular endothelial growth factor (VEGF) injections, corticosteroid injections, extended release corticosteroids, topical steroid and nonsteroidal anti-inflammatory drops and carbonic anhydrase inhibitors. (researchsquare.com)
- Forest plot for the effect of carbonic anhydrase inhibitors (CAI) vs control on serum bicarbonate. (biomedcentral.com)
- In refractory cases, systemic carbonic anhydrase inhibitors may be beneficial. (aao.org)
- 2) Acetazolamide is carbonic anhydrase inhibitors. (examyear.com)
- The tissue culture market is categorized amongst others by product categories such as amino acids, creatinine, protease inhibitors, carbonic anhydrase, and cytokines. (fnfnewsblog.com)
Enzyme8
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Carbonic Anhydrase IV (CA4) in serum, plasma and other biological fluids. (master-sistemisanitari-medicinenonconvenzionali.org)
- One current study of this microbe by Alber, B.E. and Ferry J.G., determined that Methanosaeta thermophila archaea produce a carbonic anhydrase, which is an enzyme that catalyzes the reaction of water with carbon dioxide. (kenyon.edu)
- By slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport, it may inhibit the enzyme carbonic anhydrase in the ciliary processes of the eye. (medscape.com)
- An example of an enzyme that contains a cofactor is carbonic anhydrase, which has a zinc cofactor bound as part of its active site. (cosmeticsandtoiletries.com)
- This gene provides instructions for making the carbonic anhydrase VA enzyme, which helps convert carbon dioxide to a substance called bicarbonate. (medlineplus.gov)
- The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes in the energy-producing centers of cells (mitochondria). (medlineplus.gov)
- Mutations in the CA5A gene result in absent or impaired carbonic anhydrase VA enzyme function, leading to reduced bicarbonate production. (medlineplus.gov)
- Studies suggest that a related enzyme produced from the CA5B gene may increasingly compensate for the lack of carbonic anhydrase VA as affected individuals mature, which may result in a reduced risk of metabolic crisis and acute encephalopathy after childhood. (medlineplus.gov)
Inhibitor2
- Therefore, we aim to clarify the efficacy of imeglimin in patients with type 2 diabetes (T2D) being treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor plus low-dose metformin. (bvsalud.org)
- Seventy participants with T2D treated with a DPP-4 inhibitor plus metformin (500-1000 mg/day) for more than 12 weeks and a glycated hemoglobin (HbA1c) level of 52-85 mmol/mol (7.0%-9.9%) will be randomized to receive add-on imeglimin 1000 mg two times per day or metformin dose escalation for 24 weeks. (bvsalud.org)
CAII3
- The most common cause is carbonic anhydrase II (CAII) deficiency. (bmj.com)
- In 1983, Sly et al 4 showed that in patients with this syndrome, carbonic anhydrase II (CAII) activity in erythrocytes was absent, suggesting that this was the primary defect. (bmj.com)
- The results show that the efferent ductule epithelium expressed sodium-potassium ATPase (Na(+),K(+)-ATPase), carbonic anhydrase II (CAII) and sodium hydrogen exchanger isoform 3 (NHE3) and that the connecting ductule and epididymal duct epithelia expressed Na(+),K(+)-ATPase and CAII. (cdc.gov)
Protein6
- Recombinant Human Glutamate Receptor 4 Protein [H00002893-P01] - 12.5% SDS-PAGE Stained with Coomassie Blue. (novusbio.com)
- FVB/N mice challenged with C . rodentium [1 × 10 9 colony-forming units (CFU)] with or without administration of live LA (3 × 10 9 CFU) were assessed for NHE3 and DRA mRNA and protein expression, mRNA levels of carbonic anhydrase, diarrheal phenotype (assessed by colonic weight-to-length ratio), myeloperoxidase activity, and proinflammatory cytokines. (marshall.edu)
- We use carbonic anhydrase as a model protein and charge ladders in capillary electrophoresis to study the average contributions of a particular charged group (e.g. (harvard.edu)
- NH 3 + or COO - groups) on the exterior of the protein (Figure 4). (harvard.edu)
- A demonstration of the use of our model system human carbonic anhydrase II (HCAII) to examine the influence of differences in ligand structure-in the absence of differences in protein conformation-on binding. (harvard.edu)
- But the researchers noticed that, according to the docking results, fragments such as compound 4 could assume two different binding modes: in one, the carboxylate and phenol interacted with the iron atom, while in the other the carboxylate interacted with lysine and tyrosine residues in the protein. (blogspot.com)
Inhibits2
- Inhibits topoisomerase II (DNA gyrase) and IV enzymes. (medscape.com)
- Regarding CA IV, the results lead to the conclusion that omeprazole selectively inhibits gastric mucosa CA IV and does not modify the activity of the same isozyme from the kidney and lung, indicating organ specificity. (aspetjournals.org)
Enzymes4
- thereby, inhibiting the enzymes DNA-gyrase and topoisomerase IV. (medscape.com)
- There are two enzymes, urease, and carbonic anhydrase, that play an important role in the MICP process. (frontiersin.org)
- Insufficient bicarbonate results in impaired control of acid-base balance and reduces the activity of the four affected mitochondrial enzymes, resulting in the various biochemical abnormalities associated with carbonic anhydrase VA deficiency. (medlineplus.gov)
- ZINC has been identified as a cofactor for over 70 different enzymes, including carbonic anhydrase, alkaline phosphatase, lactic dehydrogenase and both RNA and DNA polymerase. (nih.gov)
Bicarbonate3
- During an episode, people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base balance in the blood (metabolic acidosis and respiratory alkalosis), low glucose in the blood (hypoglycemia), and reduced production of a substance called bicarbonate in the liver. (medlineplus.gov)
- Carbonic anhydrase catalyzes the conversion of CO2 to bicarbonate and protons. (medscape.com)
- The H + dissociates from hemoglobin and combines with bicarbonate to form carbonic acid with the help of carbonic anhydrase, which further catalyzes the reaction to convert carbonic acid back into carbon dioxide and water. (openstax.org)
Mechanism2
- The suggested mechanism denoted an unspecified glutamate residue was phosphorylated, and the "alignment of the amino acid sequences for the acetate kinases from E. coli (Bacteria domain), Methanosarcina thermophila (Archaea domain), and four other phylogenetically divergent microbes revealed high identity which included five glutamates," (9). (kenyon.edu)
- The antihypertensive mechanism of quinethazone is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. (drugbank.com)
Deficiency7
- Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain substances in the body is disrupted (known as metabolic crisis) and brain function is abnormal (known as acute encephalopathy). (medlineplus.gov)
- People with carbonic anhydrase VA deficiency typically first experience episodes of the disorder by age 2. (medlineplus.gov)
- Between episodes, children with carbonic anhydrase VA deficiency are generally healthy, and more than half have no further episodes after the first one. (medlineplus.gov)
- Because of the small number of people with carbonic anhydrase VA deficiency who have come to medical attention, the effects of this disorder in adults are not well understood. (medlineplus.gov)
- The prevalence of carbonic anhydrase VA deficiency is unknown. (medlineplus.gov)
- researchers suspect that some babies diagnosed with transient hyperammonemia may actually have carbonic anhydrase VA deficiency. (medlineplus.gov)
- Carbonic anhydrase VA deficiency is caused by mutations in the CA5A gene. (medlineplus.gov)
Capillaries1
- A membrane-bound carbonic anhydrase found in lung capillaries and kidney. (bvsalud.org)
Intracellular2
- Intracellular carbonic anhydrase produces acid which is used to degrade bone underneat this area. (orthonet.on.ca)
- Treatment was done for four days, erythropoietic activity of each fraction was assayed by determining the effect of these fractions on intracellular hemoglobin and reticulocyte level from the blood, arginase was also assayed. (who.int)
NHE31
- LA counteracted C . rodentium -induced inhibition of colonic DRA, NHE3, and carbonic anhydrase I and IV expression and attenuated diarrheal phenotype and MPO activity. (marshall.edu)
Proton1
- The proton antenna effect of CAs in the regulation of MCT1/4. (aspetjournals.org)
MRNA1
- MSU crystals in the presence of RANKL augmented osteoclast differentiation, with enhanced mRNA expression of NFATc1, cathepsin K, carbonic anhydrase II, and matrix metalloproteinase-9 (MMP-9), in comparison to RAW 264.7 macrophages incubated in the presence of RANKL alone. (hindawi.com)
Protease1
- This bacterium produced lipase and protease at 4°C in a plate assay. (frontiersin.org)
Synthesis2
- Alvala, M. Synthesis, 18F-radiolabeling and apoptosis inducing studies of novel 4,7-disubstituted coumarins. (studyinindia.gov.in)
- Synthesis, molecular docking simulation, and biological evaluation studies of novel amide and ether conjugates of 2, 3-diaryl-1, 3-thiazolidin-4-ones. (studyinindia.gov.in)
Vascular1
- Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. (drugbank.com)
Acid2
- Hydrocyanic acid (a solution of hydrogen cyanide in water) is present in freshly distilled bitter almond oil (2-4%) prior to its removal by precipitation as calcium ferrocyanide to give food quality oil. (t3db.ca)
- When CO2 is injected into the blood, it is combined with water to produce carbonic acid. (medscape.com)
Gene1
- SHUES1 was the presence of carbonic anhydrase gene in it. (frontiersin.org)
Bacterial2
- Topoisomerase IV is essential in chromosomal DNA partitioning during bacterial cell division. (medscape.com)
- Topoisomerase IV plays a key role in chromosomal DNA portioning during bacterial cell division. (medscape.com)
Humans2
- In this study our experiments followed in vitro and in vivo the effect of omeprazole on purified and erythrocyte carbonic anhydrase (CA) I and II isozymes, as well as on gastric mucosa CA IV in humans. (aspetjournals.org)
- In vivo, the i.v. administration of omeprazole in humans in therapeutic doses produced a decrease in erythrocyte CA I and CA II activity, as well as in gastric mucosa CA I, II, and IV. (aspetjournals.org)
Produces1
- deposited in NCBI database, this is the first characterization of the genome sequence of strain SHUES1, which produces carbonic anhydrase which has a significant role in metal bioremediation based on the ability to promote the precipitation of metal carbonates. (frontiersin.org)
Bone5
- Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. (nih.gov)
- The involvement of mature, multinucleated osteoclasts is essential in explaining bone damage in chronic autoimmune inflammatory arthritides such as rheumatoid arthritis (RA) [ 4 ] and psoriatic arthritis [ 5 ]. (hindawi.com)
- Carbonic anhydrase I (CA1) is involved in the process of bone formation and is susceptible to ankylosing spondylitis. (cdc.gov)
- Bone marrow carbonic anhydrase was assayed to monitor bone marrow erythropoietic stimulation. (who.int)
- 05 0.94±0.25% close to the non anemic mice 0.97±0.25% and bone marrow carbonic anhydrase activity. (who.int)
Peptidase1
- HtrA serine peptidase 4 [S. (gsea-msigdb.org)
20201
- Record 2020, 20, 253-272 [4] Bora, D, Tokala R, John SE, Prasanth, B. Shankaraiah N. Carboline directed regioselective hydroxylation by employing Cu(OAc)2 and mechanistic investigation by ESI-MS. Org. (studyinindia.gov.in)
Intravitreal1
- The medical charts of all consecutive patients who underwent intravitreal injection with dexamethasone intravitreal implant (Ozurdex®) and fluocinolone acetonide intravitreal implant (Iluvien®) from January 1, 2015 to May 4, 2019 were retrospectively reviewed. (researchsquare.com)
Activity2
- The inhibition potency and influence of the partially restricted aryl-aryl bond rotation on the activity/selectivity were rationalized by means of X-ray crystallography of the adducts of hCA II with several 4-arylbenzenesulfonamides. (bvsalud.org)
- Carbonic anhydrase activity was measured by Maren's method. (tubitak.gov.tr)
Genome1
- Complete Genome Sequence of Carbonic Anhydrase Producing Psychrobacter sp. (frontiersin.org)
Receptor1
- Fc receptor like 4 [Source. (gsea-msigdb.org)
20221
- 2022 Jul-Aug. 67 (4):1135-1159. (medscape.com)
Description1
- A complete description of the NHAMCS is contained in the publication entitled, 'Plan and Operation of the National Hospital Ambulatory Medical Care Survey' (reference 4). (cdc.gov)
PEDIATRIC2
- TRACE ELEMENTS INJECTION 4, USP PEDIATRIC is a sterile, nonpyrogenic solution containing four Trace Elements for use as an additive for Total Parenteral Nutrition (TPN). (nih.gov)
- TRACE ELEMENTS INJECTION 4, USP PEDIATRIC should not be given undiluted by direct injection into a peripheral vein because of the potential of infusion phlebitis. (nih.gov)
Understood1
- While muscle cells have been studied for over four centuries, much remains to be understood about how these cells precisely tune their behaviors in a tissue context to potentiate the proper function of the organism. (vironinstitute.com)
Patients1
- Pain relief is experienced by 60-68% of patients within 4 hours of treatment and maintained for up to 24 hours in 49-67% of patients. (medscape.com)
Cytochrome1
- cytochrome P450 family 4 s. (gsea-msigdb.org)
Vitro1
- Our in vitro results show that omeprazole-induced inhibition of purified CA I and CA II and gastric mucosa CA IV is dose- and pH-dependent. (aspetjournals.org)
Significantly1
- CHIR99021 (2 mg/kg) given once, 4 h before irradiation, significantly improves survival after 14.5 Gy abdominal irradiation (ABI). (dcchemicals.com)
