A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-
The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.
A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial cells, and the gastrointestinal mucosa. EC 4.2.1.-
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
A membrane-bound carbonic anhydrase found in lung capillaries and kidney.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Contractile tissue that produces movement in animals.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.

Detection and identification of subcutaneous adipose tissue protein related to obesity in New Zealand obese mouse. (1/32)

New Zealand obese (NZO) mouse, a genetic model of obesity, shows hyperphagia, hyperinsulinemia and leptin resistance. We analyzed subcutaneous adipose tissue proteins in NZO mice with a two-dimensional gel electrophoresis technique followed by protein sequence analysis. NZO mice showed hyperinsulinemia and hyperleptinemia. Abdominal subcutaneous adipose tissue was inspected in NZO and C57BL/6J lean mice. Two-dimensional gel electrophoresis detected 4 spots which were obviously reduced in NZO mice. Those spots were p26, p19, p18 and p15. Internal sequences of the p26 and p15 protein were homologous with those of carbonic anhydrase III, p19 was cytochrome b5, p18 was superoxide dismutase. Serum arachidonic acid level in NZO mice was lower by 80% of C57BL/6J mice. The present study demonstrated the reduction of several enzymes related to lipid metabolism in NZO mice. These data raises the hypothesis that the supposed changes of membrane fluidity caused by altered membrane lipid content may involve central leptin resistance of this model of obesity.  (+info)

Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. (2/32)

We have prepared a site-specific mutant of human carbonic anhydrase (HCA) II with histidine residues at positions 7 and 64 in the active site cavity. Using a different isozyme, we have placed histidine residues in HCA III at positions 64 and 67 and in another mutant at positions 64 and 7. Each of these histidine residues can act as a proton transfer group in catalysis when it is the only nonliganding histidine in the active site cavity, except His(7) in HCA III. Using an (18)O exchange method to measure rate constants for intramolecular proton transfer, we have found that inserting two histidine residues into the active site cavity of either isozyme II or III of carbonic anhydrase results in rates of proton transfer to the zinc-bound hydroxide that are antagonistic or suppressive with respect to the corresponding single mutants. The crystal structure of Y7H HCA II, which contains both His(7) and His(64) within the active site cavity, shows the conformation of the side chain of His(64) moved from its position in the wild type and hydrogen-bonded through an intervening water molecule with the side chain of His(7). This suggests a cause of decreased proton transfer in catalysis.  (+info)

Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. (3/32)

During fasting and many systemic diseases, muscle undergoes rapid loss of protein and functional capacity. To define the transcriptional changes triggering muscle atrophy and energy conservation in fasting, we used cDNA microarrays to compare mRNAs from muscles of control and food-deprived mice. Expression of >94% of genes did not change, but interesting patterns emerged among genes that were differentially expressed: 1) mRNAs encoding polyubiquitin, ubiquitin extension proteins, and many (but not all) proteasome subunits increased, which presumably contributes to accelerated protein breakdown; 2) a dramatic increase in mRNA for the ubiquitin ligase, atrogin-1, but not most E3s; 3) a significant suppression of mRNA for myosin binding protein H (but not other myofibrillar proteins) and IGF binding protein 5, which may favor cell protein loss; 4) decreases in mRNAs for several glycolytic enzymes and phosphorylase kinase subunits, and dramatic increases in mRNAs for pyruvate dehydrogenase kinase 4 and glutamine synthase, which should promote glucose sparing and gluconeogenesis. During fasting, metallothionein mRNA increased dramatically, mRNAs for extracellular matrix components fell, and mRNAs that may favor cap-independent mRNA translation rose. Significant changes occurred in mRNAs for many growth-related proteins and transcriptional regulators. These transcriptional changes indicate a complex adaptive program that should favor protein degradation and suppress glucose oxidation in muscle. Similar analysis of muscles atrophying for other causes is allowing us to identify a set of atrophy-specific changes in gene expression.  (+info)

Studies of proton translocations in biological systems: simulating proton transport in carbonic anhydrase by EVB-based models. (4/32)

Proton transport (PTR) processes play a major role in bioenergetics and thus it is important to gain a molecular understanding of these processes. At present the detailed description of PTR in proteins is somewhat unclear and it is important to examine different models by using well-defined experimental systems. One of the best benchmarks is provided by carbonic anhydrase III (CA III), because this is one of the few systems where we have a clear molecular knowledge of the rate constant of the PTR process and its variation upon mutations. Furthermore, this system transfers a proton between several water molecules, thus making it highly relevant to a careful examination of the "proton wire" concept. Obtaining a correlation between the structure of this protein and the rate of the PTR process should help to discriminate between alternative models and to give useful clues about PTR processes in other systems. Obviously, obtaining such a correlation requires a correct representation of the "chemistry" of PTR between different donors and acceptors, as well as the ability to evaluate the free energy barriers of charge transfer in proteins, and to simulate long-time kinetic processes. The microscopic empirical valence bond (Warshel, A., and R. M. Weiss. 1980. J. Am. Chem. Soc. 102:6218-6226; and Aqvist, J., and A. Warshel. 1993. Chem. Rev. 93:2523-2544) provides a powerful way for representing the chemistry and evaluating the free energy barriers, but it cannot be used with the currently available computer times in direct simulation of PTR with significant activation barriers. Alternatively, one can reduce the empirical valence bond (EVB) to the modified Marcus' relationship and use semimacroscopic electrostatic calculations plus a master equation to determine the PTR kinetics (Sham, Y., I. Muegge, and A. Warshel. 1999. Proteins. 36:484-500). However, such an approximation does not provide a rigorous multisite kinetic treatment. Here we combine the useful ingredients of both approaches and develop a simplified EVB effective potential that treats explicitly the chain of donors and acceptors while considering implicitly the rest of the protein/solvent system. This approach can be used in Langevin dynamics simulations of long-time PTR processes. The validity of our new simplified approach is demonstrated first by comparing its Langevin dynamics results for a PTR along a chain of water molecules in water to the corresponding molecular dynamics simulations of the fully microscopic EVB model. This study examines dynamics of both models in cases of low activation barriers and the dependence of the rate on the energetics for cases with moderate barriers. The study of the dependence on the activation barrier is next extended to the range of higher barriers, demonstrating a clear correlation between the barrier height and the rate constant. The simplified EVB model is then examined in studies of the PTR in carbonic anhydrase III, where it reproduces the relevant experimental results without the use of any parameter that is specifically adjusted to fit the energetics or dynamics of the reaction in the protein. We also validate the conclusions obtained previously from the EVB-based modified Marcus' relationship. It is concluded that this approach and the EVB-based model provide a reliable, effective, and general tool for studies of PTR in proteins. Finally in view of the behavior of the simulated result, in both water and the CA III, we conclude that the rate of PTR in proteins is determined by the electrostatic energy of the transferred proton as long as this energy is higher than a few kcal/mol.  (+info)

Carbonic anhydrase III is not required in the mouse for normal growth, development, and life span. (5/32)

Carbonic anhydrase III is a cytosolic protein which is particularly abundant in skeletal muscle, adipocytes, and liver. The specific activity of this isozyme is quite low, suggesting that its physiological function is not that of hydrating carbon dioxide. To understand the cellular roles of carbonic anhydrase III, we inactivated the Car3 gene. Mice lacking carbonic anhydrase III were viable and fertile and had normal life spans. Carbonic anhydrase III has also been implicated in the response to oxidative stress. We found that mice lacking the protein had the same response to a hyperoxic challenge as did their wild-type siblings. No anatomic alterations were noted in the mice lacking carbonic anhydrase III. They had normal amounts and distribution of fat, despite the fact that carbonic anhydrase III constitutes about 30% of the soluble protein in adipocytes. We conclude that carbonic anhydrase III is dispensable for mice living under standard laboratory husbandry conditions.  (+info)

Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry. (6/32)

This study aimed to evaluate tumour hypoxia by comparing [(18)F]Fluoromisonidazole uptake measured using positron emission tomography ([(18)F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic rhabdomyosarcoma (R1) tumour pieces were transplanted subcutaneously in the flanks of WAG/Rij rats. Tumours were analysed at volumes between 0.9 and 7.3 cm(3). Hypoxic volumes were defined using a 3D region of interest on 2 h postinjection [(18)F]FMISO-PET images, applying different thresholds (1.2-3.0). Monoclonal antibodies to pimonidazole (PIMO) and carbonic anhydrase IX (CA IX), exogenous and endogenous markers of hypoxia, respectively, were used for IHC staining. Marker-positive fractions were microscopically measured for each tumour, and hypoxic volumes were calculated. A heterogeneous distribution of hypoxia was observed both with histology and [(18)F]FMISO autoradiography. A statistically significant correlation (P<0.05) was obtained between the hypoxic volumes defined with [(18)F]FMISO-PET and the volumes derived from the PIMO-stained tumour sections (r=0.9066; P=0.0001), regardless of the selected threshold between 1.4 and 2.2. A similar observation was made with the CA IX staining (r=0.8636; P=0.0006). The relationship found between [(18)F]FMISO-PET and PIMO- and additionally CA IX-derived hypoxic volumes in rat rhabdomyosarcomas indicates the value of the noninvasive imaging method to measure hypoxia in whole tumours.  (+info)

Taste buds and nerve fibers in the rat larynx: an ultrastructural and immunohistochemical study. (7/32)

We investigated the rat laryngeal taste buds and their innervation by electron microscopy and immunohistochemical methods. Taste buds were densely arranged in the surface facing the laryngeal cavity of the epiglottis, the aryepiglottic fold, and the cuneiform process of the arytenoid cartilages. The cells of the buds were classified into types I, II, III, and basal cells, the ultrastucture of which was almost the same as that previously reported in lingual taste buds. The type III cells that had synaptic contacts with nerve fibers were considered to be sensory cells. Immunohistochemical analysis revealed thick calbindin D28k-immunoreactive fibers and thin varicose fibers immunoreactive for calcitonin gene-related peptide or substance P in and around the taste bud. Serotonin-immunoreactive cells were also observed here. The results revealed the innervation pattern of laryngeal taste buds to be the same as that in lingual taste buds. Carbonic anhydrase (CA) is known to catalyze the hydration of CO2 and dehydration of H2CO3, and seems to be essential in CO2 reception. Immunoreactivity for CAI was detected in slender cells and that for CAIII was observed in barrel-like cells in the laryngeal taste buds. The pH-sensitive inward rectifier K+ (Kir) channel in the cell membrane may be involved in CO2 reception as well. CAII-reactive cells were also reactive to Kir4.1, PGP 9.5 and serotonin. Our results indicated that CAII and Kir4.1 are located in type III cells of the laryngeal taste buds, and supported the idea that the buds may be involved in the recognition of CO2.  (+info)

Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of rat. (8/32)

The effect of an aryl hydrocarbon receptor (AhR) ligand on the carbonic anhydrase III (CAIII) mRNA level was studied using primary cultured hepatocytes of rats. CAIII gene which is highly suppressible by dioxins in vivo, was also suppressible in primary cultured hepatocytes of rats by an AhR ligand, 3-methylchlanthrene (3MC). The suppression of CAIII by 3MC was observed in a dose-dependent fashion. The suppression was marked at 10 microM MC. It is likely that AhR is involved in the suppression of the CAIII gene. The transcriptional regulation region of rat CAIII gene was cloned by polymerase chain reaction on the basis of the similarity to the mouse and human CAIII genes. A 1.5 kb section upstream of rat CAIII was sequenced and the transcription initiation site of this gene was mapped to 58 bases upstream of the initiation codon. A xenobiotic responsive element (XRE)-like sequence was found at -555 to -549 bp of the transcription initiation site. The location of XRE-like element was conserved between rats and mice those CAIIIs in liver were shown as dioxins-suppressible. Although the roles of the XRE have not been clarified, these results suggest that the AhR ligands could elicit the suppressive effect on hepatic CAIII and the effect on the factors from extrahepatic tissues is not required for the suppression.  (+info)

TY - JOUR. T1 - Significant suppression of aldolase B, carbonic anhydrase III and alcohol dehydrogenase in liver cytosol of rats treated with a highly toxic coplanar PCB. AU - Kato, H.. AU - Ishii, Y.. AU - Hatsumura, M.. AU - Ishida, T.. AU - Nakayama, I.. AU - Ariyoshi, N.. AU - Oguri, K.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1997. Y1 - 1997. UR - http://www.scopus.com/inward/record.url?scp=0030893411&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0030893411&partnerID=8YFLogxK. U2 - 10.1248/jhs1956.43.P20. DO - 10.1248/jhs1956.43.P20. M3 - Article. AN - SCOPUS:0030893411. VL - 43. SP - P20. JO - Japanese Journal of Toxicology and Environmental Health. JF - Japanese Journal of Toxicology and Environmental Health. SN - 0013-273X. IS - 1. ER - ...
Mouse Monoclonal Anti-Carbonic Anhydrase III/CA3 Antibody (4A12-1A3). Validated: WB, ELISA, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
Human carbonic anhydrase 8 (CA-VIII) is an acatalytic isoform of the α -CA family. Though the protein cannot hydrate CO2, CA-VIII is essential for calcium (Ca2+) homeostasis within the body, and achieves this by allosterically inhibiting the binding of inositol 1,4,5-triphosphate (IP3) to the IP3 receptor type 1 (ITPR1) protein. However, the mechanism of interaction of CA-VIII to ITPR1 is not well understood. In addition, functional defects to CA-VIII due to non-synonymous single nucleotide polymorphisms (nsSNVs) result in Ca2+ dysregulation and the development of the phenotypes such as cerebellar ataxia, mental retardation and disequilibrium syndrome 3 (CAMRQ3). The pathogenesis of CAMRQ3 is also not well understood. The structure and function of CA-VIII was characterised, and pathogenesis of CAMRQ3 investigated. Structural and functional characterisation of CA-VIII was conducted through SiteMap and CPORT to identify potential binding site residues. The effects of four pathogenic nsSNVs,
Measuring proteins involved in glucose and fatty acid metabolism before and after an 8-wk VLED reflects the metabolic adaptations occurring in adipose tissue linked to energy expenditure. More specifically, the decrease of AldoC, an enzyme of glycolysis, is correlated with the decrease in AEE, and the non-significant change HADHsc, a crucial enzyme for mitochondrial beta-oxidation, is negatively correlated with the adaptation in REE. Furthermore, there is a correlation between the increase in FABP4, the intracellular fatty acid transporter, and the decrease in fat mass, and a correlation between the decrease in AldoC and the decrease in fat free mass. FABP4, AldoC and HADHsc are all positively correlated.. The increased FABP4 after the VLED weight loss is in accordance with previous results in obese subjects [11, 12, 44]. It is in line with an elevation in intracellular trafficking of fatty acids, which is expected during a negative energy balance when lipolysis is stimulated, with the release ...
Supplementary MaterialsS1 Dataset: Minimal data established. clinic. The blood S-glutathionylated GAPDH levels in the AD patients were significantly (p 0.001) higher (752.7 301.7 ng/dL) than those in the controls (59.92 122.4 ng/dL), irrespective of gender and age. For AD analysis, the criterion blood S-glutathionylated GAPDH level 251.62 ng/dL exhibited 95.74% sensitivity and 92.67% specificity. In fact, the individuals aged 70C89 years, namely, 37 patients from your psychosomatic medical center and 42 healthy individuals, showed significant blood S-glutathionylated GAPDH levels (230.5 79.3 and 8.05 20.51 ng/dL, respectively). This getting might indicate neurodegenerative AD progression in psychosomatic individuals and suggests that the degree of neuronal apoptosis during AD progression might be sensitively evaluated based on the level of S-glutathionylated GAPDH in blood. Introduction The majority of dementia cases can be diagnosed as AD [1], which is definitely classified like a ...
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008 ...
How many net carbs are in Tomato Paste? Amount of Proline in Tomato paste: How much Serine is in Tomato paste? thank you! Amount of Tyrosine in Tomato paste: How much Valine is in Tomato paste? Tomato Paste #1 All Concentrations in ppm Chloride Sodium Potassium Magnesium Calcium Dilution Replicate 1 5210 2010 12,220 420 130* 166.32 Replicate 2 5270 200 12,320 430 130* 166.32 Replicate 3 5270 2070 12,340 430 140* 166.32 Average 5250 2050 12,290 430 130* RSD (%) 0.68 1.6 0.55 1.4 2.3 *Below reporting limit of 166 ppm . Amount of Choline in Tomato paste: How much Betaine is in Tomato paste? It contains mostly carbohydrates -- about 3 grams in 1 tablespoon -- along with a tiny amount of protein and almost no fat. Amount of Zinc in Tomato paste: How much Copper is in Tomato paste? Nutrition facts and Information for Hunts Tomato Paste, canned in Home ... Vitamin C and Potassium. Caloric Ratio Pyramid. Having kidney disease can make it harder for your body to maintain a healthy potassium level of ...
C. Biswas, K. Devarajan, T. K. Panda, and S. S. K. Raavi, Enhanced Broadband Emission in Novel Phenanthroimidazole Derivative Molecules via Excited State Intramolecular Proton Transfer, in OSA Advanced Photonics Congress (AP) 2020 (IPR, NP, NOMA, Networks, PVLED, PSC, SPPCom, SOF), L. Caspani, A. Tauke-Pedretti, F. Leo, and B. Yang, eds., OSA Technical Digest (Optical Society of America, 2020), paper JTh3G.5 ...
I love this stuff. The other day I was making a soup out of some kale from the garden, some leftover chickpeas and a few odd potatoes (along with a bay leaf, some garlic and fresh thyme). But it needed something.. Found in the fridge: an almost used-up tube of Mutti tomato paste. I squeezed in a little and my soup came together. I really wouldnt do it with any other tomato paste, but Mutti of Parma, Italy, produces the best.. Theyve been making it since 1899. Their paste is double-concentrated and made only from tomatoes and salt. Thats it. After all the companys motto is solo pomodoro. Per passione - only tomatoes, for passion.. The firm uses only Italian tomatoes and a slow process of dehydration. Its easy to taste the difference - none of that sludgy, bitter or cooked-down taste of regular tomato paste. This tastes bright and carries the deep flavor of sun-warmed tomatoes.. Use it to beef up the tomato taste of a sauce, or add an underlying tomato note to a brasato or stew.. Any cook ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Centos all-natural, authentically prepared tomato paste is 100% Italian and a favorite of ours for years. We love the innovative packaging that makes using and sto...
1E9O: Conformational Variability of the Cu Site in One Subunit of Bovine Cuzn Superoxide Dismutase: The Importance of Mobility in the Glu119-Leu142 Loop Region for Catalytic Function
UV and IR photochemistries of malonaldehyde, the simplest molecule exhibiting an intramolecular proton exchange, have been studied in four cryogenic matrices at 4.3 K, N2, Ne, Ar and Xe. Samples have been irradiated using a UV and IR OPO type tunable laser, and with a broad band UV mercury lamp. UV and IR spectra have been recorded and compared with theoretical calculations carried out at the SAC-CI/6-31++G(d,p) (UV transitions) and B3LYP/6-311++G(2d,2p) (IR spectra) levels of theory. After de- position, the intramolecularly H-bonded form is found exclusively, while several open forms are formed upon UV irradiation ...
Semantic Scholar extracted view of Follow-up studies of iliofemoral arterial reconstruction in arteriosclerosis obliterans. by Sarah Hoye et al.
See all results for Spaghetti Casserole No Null No (tomato Paste) Recipes. Find more recipes at Foodily.com - the largest recipe search site - and see the ones your friends like.
In addition to the Steered MD (SMD) approach described starting on page 108 of the manual, a new set of Adaptively Biased MD and related methods has been introduced for Amber10 (See page 121 and also be aware that this tutorial uses an Amber11 addition, LCOD, to these methods. Adding LCOD capabilities to Amber10 is described below). The whole Adaptively Biased MD section (4.6) should be studied for background to this tutorial. The new implementation of the SMD method specifically is described starting on page 125. The tutorial is a brief test case using steered MD to force an intramolecular proton transfer (PT) in malonaldehyde (pictured). The simulation was carried out in vacuum with the QMMM DFTB Hamiltonian using the LCOD (linear combination of distances) reaction coordinate. The QM region consisted of the whole molecule. These results should be compared with the Empirical Valence Bond (EVB) section, specifically to Figure 3.4 (page 77, closed triangles). As indicated above the LCOD reaction ...
1TG3: Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
为解决新疆番茄酱加工废水排放量大、处理效果参差不齐的情况,在SBR(序批式反应器)中接种絮体污泥,以人工合成番茄酱加工废水为基质成功培养出粒径为0.50~1.61 mm的好氧颗粒污泥,并采用扫描电镜、三维荧光光谱(3D EEM)、激光共聚焦(CLSM)、死活细菌染色以及高通量测序等技术表征活性污泥的颗粒化过程.结果表明,颗粒污泥沉降性能良好,CODCr、NH4+-N、PO43--P的平均去除率分别为90%、85%、45%.扫描电镜下,椭球状的颗粒污泥轮廓清晰,结构密实.蛋白质在颗粒化过程中逐渐增加,α-多糖、β-多糖和蛋白质贯穿整个颗粒截面,在颗粒中分布广泛,构成了颗粒的骨架.颗粒内部的孔隙为溶解氧和营养物质传递提供了条件,因此活细菌则更多地靠近颗粒边缘及内部的孔隙周围,并包裹着死细菌.颗粒化过程中
Most loss-of-function diseases are caused by aberrant folding of important proteins. These proteins often misfold due to inherited mutations. The rare disease marble brain disease (MBD) also known as carbonic anhydrase II deficiency syndrome (CADS) can manifest in carriers of point mutations in the human carbonic anhydrase II (HCA II) gene. We have over the past 10-15 years studied the folding, misfolding and aggregation of the enzyme human carbonic anhydrase II. In summary our HCA II folding studies have shown that the protein folds via an intermediate of molten-globule type, which lacks enzyme activity and the molten globule state of HCA II is prone to aggregation. One mutation associated with MBD entails the His107Tyr (H107Y) substitution. We have demonstrated that the H107Y mutation is a remarkably destabilizing mutation influencing the folding behavior of HCA II. A mutational survey of position H107 and a neighboring conserved position E117 has been performed entailing the mutants H107A, ...
View reliable Canned Food manufacturers on Made-in-China.com. This category presents Tomato Paste, Canned Tomato Paste, from China Canned Food suppliers to global buyers., page 3
Aryl sulfonamides are a widely used drug class for the inhibition of carbonic anhydrases. In the context of our program of photochromic pharmacophores we were interested in the exploration of azobenzene-containing sulfonamides to block the catalytic activity of human carbonic anhydrase II (hCAII). Herein, we report the synthesis and in vitro evaluation of a small library of nine photochromic sulfonamides towards hCAII. All molecules are azobenzene-4-sulfonamides, which are substituted by different functional groups in the 4 -position and were characterized by X-ray crystallography. We aimed to investigate the influence of electrondonating or electron-withdrawing substituents on the inhibitory constant Ki. With the aid of an hCAII crystal structure bound to one of the synthesized azobenzenes, we found that the electronic structure does not strongly affect inhibition. Taken together, all compounds are strong blockers of hCAII with K-i = 25-65 nM that are potentially photochromic and thus combine ...
Entrepreneurs say the crisis has been worsened by the central banks decision to keep an artificially high exchange rate, which has dried up dollar supplies, forcing firms to buy them on the black market at a 40 per cent premium.Where the foreign exchange is not available, we are cutting down our operations. For example, we had a tomato-based processing plant, we have shut it down, Tomato paste is a staple food in Nigeria but the country imports much of its supplies from China. Dangotes plant opened only last year amid much talk from officials predicting a new era of Nigeria producing its own tomato paste, displacing costly imports ...
ESCUDERO-ALMANZA, Dalila Jacqueline et al. Carbonic Anhydrase and Zinc in Plant Physiology. Chilean J. Agric. Res. [online]. 2012, vol.72, n.1, pp.140-146. ISSN 0718-5839. http://dx.doi.org/10.4067/S0718-58392012000100022.. Carbonic anhydrase (CA) (EC: 2.4.1.1) catalyzes the rapid conversion of carbon dioxide plus water into a proton and the bicarbonate ion (HCO3-) that can be found in prokaryotes and higher organisms; it is represented by four different families. Carbonic anhydrase is a metalloenzyme that requires Zn as a cofactor and is involved in diverse biological processes including pH regulation, CO2 transfer, ionic exchange, respiration, CO2 photosynthetic fixation, and stomatal closure. Therefore, the review includes relevant aspects about CA morphology, oligomerization, and structural differences in the active site. On the other hand, we consider the general characteristics of Zn, its geometry, reactions, and physiology. We then consider the CA catalysis mechanism that is carried out ...
MediSavvy has been developed as an educational platform and learning resource for health professionals, as well as patients that are keen to learn more about their conditions. ...
Nutrition Facts for Chestnut Hill - Tomato Paste - Get a bar chart of the top 10 nutrients, and click to see an expanded list of over 151 nutrients, including amino acids.
5315 K-ras is mutated in many lung adenocarcinomas, but the nature of its contribution to the development and maintenance of these cancers is poorly understood. Generation of reactive oxygen species (ROS) is proposed to be part of its mechanism of action. We pursued this hypothesis in 12 lung adenocarcinoma cell lines expressing mutant K-ras and 8 lines with only wildtype K-ras. K-ras total protein showed a 14-fold variation in amount among the cell lines and was as high on average in cells with wildtype K-ras, as in those with mutant protein. As expected K-ras activity was much higher in lines with mutant K-ras, varied 6-fold among these, and correlated strongly with protein levels. Mn and CuZn superoxide dismutase (SOD) protein levels varied approximately 2-fold among the cell lines. Only MnSOD varied significantly with the parameters measured, and showed a weak positive correlation with levels of superoxide (as measured by reduction of nitroblue tetrazolium) and a strong negative correlation ...
Shop a large selection of Sample Prep Tools for Mass Spectrometry products and learn more about Alfa Aesar Carbonic Anhydrase Digest Standard, Certified Mass Spec Grade Quantity:
Abstract Tomato pomace is a by-product of producing tomato paste and sauce composed by a mixture of seed, skin, and pulp that could be used in animal diets. It ...
Protein S-glutathionylation is a reversible post-translational modification regulating sulfhydryl homeostasis. However, little is known about the proteins and pathways regulated by S-glutathionylation in whole organisms and current approaches lack the sensitivity to examine this modification under basal conditions. We now report the quantification and identification of S-glutathionylated proteins from animal tissue, using a highly sensitive methodology combining high-accuracy proteomics with Tandem Mass Tagging to provide precise, extensive coverage of S-glutathionylated targets in mouse liver. Critically, we show significant enrichment of S-glutathionylated mitochondrial and Krebs cycle proteins, identifying that S-glutathionylation is heavily involved in energy metabolism processes in vivo . Furthermore, using mice nulled for glutathione S-transferase Pi (GSTP) we address the potential for S-glutathionylation to be mediated enzymatically. The data demonstrate the impact of S-glutathionylation ...
Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal aorta and the small- and medium-sized arteries of the lower extremities, which may lead to absent dorsalis pedis, posterior tibial, and/or popliteal artery pulses. It is characterized by fibrosis of the tunica intima and calcification of the tunica media. Arteriosclerosis Monckebergs arteriosclerosis Skin lesion James, William D.; Berger, Timothy G.; et al. (2006). Andrews Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0 ...
In the catalysis of the hydration of carbon dioxide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His64) shuttles protons between the zinc-bound solvent molecule and the bulk solution. To evaluate the effect of the position of the shuttle histidine and …
SLC4A5 is a sodium-bicarbonate co-transporter involved with sodium homeostasis. Based on unpublished data, two SLC4A5 single nucleotide polymorphisms (SNPs rs1017783 and rs7571842) have been highly associated with an individuals salt-sensitivity status. Since the renal proximal tubule (RPT) regulates a large percentage of renal sodium transport, we investigated whether SLC4A5 was present in this nephron segment. Using confocal immunofluorescence microscopy, we found expression of SLC4A5 in human RPT cell plasma membrane and intracellular membrane vesicles. We then examined the physiologic implications of the SLC4A5 SNPs in human RPT cells. Using immunoblotting and RT-PCR, we found no significant differences in basal SLC4A5 expression in RPT cells between individuals that are homozygous variant at both SNPs and individuals that are wild-type (WT) for both alleles. Stimulation of the dopaminergic system with 1μM fenoldopam, or the renin-angiotensin system with 10 nM angiotensin II or 10 nM ...
The photophysics of the fluorescent probe Lucifer yellow CH has been investigated using fluorescence spectroscopic and computational techniques. The nonradiative rate is found to pass through a minimum in solvents of intermediate empirical polarity. This apparently anomalous behavior is rationalized by considering the possibility of predominance of different kinds of nonradiative processes, viz. intersystem crossing (ISC) and excited-state proton transfer (ESPT), in solvents of low and high empirical polarity, respectively. The feasibility of the proton transfer is examined by the structure determined by the density functional theory (DFT) calculations. The predicted energy levels based on the time-dependent density functional theory (TD-DFT) method in the gas phase identifies the energy gap between the S-1 and nearest triplet state to be close enough to facilitate ISC. Photophysical investigation in solvent mixtures and in deuterated solvents clearly indicates the predominance of the ...
cansSAR 3D Structure of 3DC3 | USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | 3DC3_A | Carbonic anhydrase 2 - Also known as CAH2_HUMAN, CA2. Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Interacts with SLC26A6 isoform 4 (via C-terminus cytoplasmic domain).
Complete a form to schedule an appointment with a licensed UnitedHealthcare® insurance agent to discuss a Medicare Advantage plan that may be right for you.
BioAssay record AID 644085 submitted by ChEMBL: Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis.
In this study, bovine articular and human chondrocytes from the C-20/A4 cell line were tested for the functional activity and molecular presence of the enzyme carbonic anhydrase. This enzyme is classically considered to be important in the maintenance of high cellular buffering capacity by catalysing the slow attainment of equilibrium between CO(2) and HCO(3)(-). The first functional assay measured the rate of pH equilibration after administration of a fixed dose of CO(2) solution to cell lysates. Compared to positive controls (human erythrocytes, murine M1 cells and purified carbonic anhydrase), chondrocyte lysates attained equilibrium at a significantly slower rate, similar to the rate obtained with a negative control (Xenopus oocytes). A second functional assay studied CO(2) hydration kinetics in intact C-20/A4 cells, using a pH-sensitive fluorescent dye, as the CO(2) content of the extracellular solution was changed. It was shown that C-20/A4 cells accelerate hydration only to a small degree.
The enzyme carbonic anhydrase has been well characterized in mammalian systems, but the structural properties of the plant isozymes remain elusive. To investigate the nature of the zinc-binding site in spinach carbonic anhydrase, we targeted potential zinc ligands for mutagenesis and examined the re …
In the catalysis of the hydration of carbon dioxide and dehydration of bicarbonate by human carbonic anhydrase II (HCA II), a histidine residue (His64) shuttles protons between the zinc-bound solvent molecule and the bulk solution. To evaluate the effect of the position of the shuttle histidine and pH on proton shuttling, we have examined the catalysis and crystal structures of wild-type HCA II and two double mutants: H64A/N62H and H64A/N67H HCA II. His62 and His67 both have their side chains extending into the active-site cavity with distances from the zinc approximately equivalent to that of His64. Crystal structures were determined at pH 5.1-10.0, and the catalysis of the exchange of (18)O between CO(2) and water was assessed by mass spectrometry. Efficient proton shuttle exceeding a rate of 10(5) s(-)(1) was observed for histidine at positions 64 and 67; in contrast, relatively inefficient proton transfer at a rate near 10(3) s(-)(1) was observed for His62. The observation, in the crystal ...
TY - JOUR. T1 - Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization. AU - Barberi, Theresa. AU - Martin, Allison. AU - Suresh, Rahul. AU - Barakat, David J.. AU - Harris-Bookman, Sarah. AU - Drake, Charles G.. AU - Lim, Michael. AU - Friedman, Alan David. PY - 2018/1/1. Y1 - 2018/1/1. N2 - High-grade gliomas harbor abundant myeloid cells that suppress anti-tumor immunity and support tumor growth. Targeting transcription factors, such as NF-κB p50, that mediate suppressive myeloid M2 polarization may prove therapeutic. GL261-Luc glioblastoma cells were inoculated into wild-type and p50−/− mice, followed by analysis of tumor growth, survival, tumor myeloid cells, and T cells. The absence of host p50 slows tumor growth and enables regression in 30% of recipients, leading to prolonged survival. Tumors developing in p50−/− mice possess a greater concentration of ...
Carbonic anhydrase IX (CAIX) is a hypoxia-induced, membrane-tethered enzyme that is highly expressed in many cancers. It catalyses the hydration of CO 2 to HCO3- and H+, and the reverse dehydration reaction. Recent studies have shown an important role for CAIX in pH regulation and it has been speculated that CAIX may play a role in supporting cancer progression towards more aggressive forms of the disease. Clinical correlative studies in many tumours have shown that high expression is related to poor outcome. In the present study, we have selected antigen-binding antibody fragments (Fab) against human CAIX by phage-display, and tested these for inhibitory potency on CAIX catalytic activity. Inhibition was assessed from the kinetics of the CAIX-catalysed reaction, using assays performed on intact cells over-expressing CAIX, and their CAIX-containing membrane fragments. Inhibition was also assessed in multi-cellular tissue-models (spheroids) from the kinetics of CO2 venting. We have identified a Fab
Recombinant Carbonic Anhydrase VII (CA7) Protein. Species: Rat (Rattus). Source: Escherichia coli (E. coli). Order product ABIN6302725.
The cytosolic isoform XIII is a recently discovered member of the human carbonic anhydrase (hCA, EC 4.2.1.1) family. It is selectively expressed among other tissues in the reproductive organs, where it may control pH and ion balance regulation, ensuring thus proper fertilization conditions. The authors report here the X-ray crystallographic structure of this isozyme in the unbound state and in complex with a classical sulfonamide inhibitor, namely acetazolamide. A detailed comparison of the obtained structural data with those already reported for other CA isozymes provides novel insights into the catalytic properties of the members of this protein family. On the basis of the inhibitory properties of acetazolamide against various cytosolic/transmembrane isoforms and the structural differences detected within the active site of the various CA isoforms, further prospects for the design of isozyme-specific CA inhibitors are here proposed. Proteins 2008. (c) 2008 Wiley-Liss, Inc. Crystal structure of ...
Rafael MS, Laizé V, Bensimon-Brito A, Leite RB, Schüle R, M. Cancela L. Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell Mol Life Sci. 2012;69(3):423-34. doi:10.1007/s00018-011-0754-y ...
Who knew that a Mao-era Chinese agricultural conglomerate dominates the African tomato market and supplies global food companies? A hundred (...)
SWISS-MODEL Template Library (SMTL) entry for 1t9n.1. Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II
Paste Packing Price - Select 2017 high quality Paste Packing Price products in best price from certified Chinese Paste Liquid Packing Machine manufacturers, Tomato Paste Packing suppliers, wholesalers and factory on Made-in-China.com
Well you run and you run to catch up with the Sun but its sinking, racing around to come up behind you again. The Sun is the same in a relative way but youre older, shorter of breath and one day closer to death. -Pink Floyd For the last four-and-a-half billion years, the Earth has spun on its axis, orbiting its parent star: our Sun. Today, our home planet looks something like this.
This story was pencilled, inked and lettered in four-and-a-half hours, in front of a watching audience, at a charity work-in which took place at UK Comic Art Convention 1988 ...
Video: Jelle Bakker, who has a fondness for complex marble runs, made this epic 228m long sand track that descends some 38m from its start to its finish. The 12 marbles competing in this video take almost four-and-a-half minutes to complete the run, and youll be surprised to find yourself…. ...
Over the weekend, I climbed the Everest of lectin-free conversion dishes. I attempted a slow-cooked chili with no tomatoes, no peppers, and no beans. Ive tried Dr. Gundrys skinny chili in the past, and, although delicious, I was left wanting a chili that had a thick chili texture (i.e. one with tomato paste) In the…. ...
Take pleasure in contemporary-baked lasagna in lower than forty five minutes with our Lasagna Little Massive Meal. I let the lasagna sit at room temp about an hour before I baked it and then upped the cooking time by quarter-hour, including a few minutes under broil, to brown the cheese a bit. Primarily as a result of I like the style of the tomato paste, but additionally because the recipe my mother used known as for it. It helps thicken it up. I am going to let you understand how it turns out. Alternately, if fresh pasta is difficult to seek out the place you are, replenish on no-boil (entire wheat, if attainable) lasagna sheets.. Oh yeah, I also wanted to say that my lasagna was a tad soupy, and I imagine that it might have been worse had I not put it in the fridge in a single day (the place everyrhing had a chance to attract up among the juices. Individuals like it their manner, and will struggle to the demise for it. Im not going to sit down right here and lecture you on the price of ...
... where carbonic anhydrase catalyzes its hydration to carbonic acid (H2CO3). Carbonic acid then spontaneously dissociates to form ... The underlying properties creating the chloride shift are the presence of carbonic anhydrase within the RBCs but not the plasma ... Continuous process of carbonic acid dissociation and outflow of bicarbonate ions would eventually lead to a change of ... Inward movement of bicarbonate via the Band 3 exchanger allows carbonic anhydrase to convert it to CO2 for expiration. The ...
A full length CcmM protein consists of a gamma-carbonic anhydrase domain on and three to five small subunit-like domains (SSLDs ... Likewise, in some cyanobacterial strains the beta-carboxysomes contain a beta-carbonic anhydrase that is not found in the ccm ... The signature proteins of the beta-carboxysome are Form IB RuBisCO and a gamma carbonic anhydrase homolog. Beta-carboxysomes ... CsoSCA is a shell-associated beta-carbonic anhydrase. Studies in Halothiobacillus neapolitanus have shown that empty shells of ...
Other markers of muscle damage, such as aldolase, troponin, carbonic anhydrase type 3 and fatty acid-binding protein (FABP), ... Three main modalities of RRT are available: hemodialysis, continuous hemofiltration and peritoneal dialysis. The former two ... 25 (3): 332-47. doi:10.1002/mus.10053. PMID 11870710. S2CID 8731940. Elsayed EF, Reilly RF (January 2010). "Rhabdomyolysis: a ... 25 (3): 199-209. doi:10.2165/00139709-200625030-00004. PMID 17192123. S2CID 24320633. Buchholz U, Mouzin E, Dickey R, Moolenaar ...
... and use carbonic anhydrase mediated active transport to speed up this process. Large diatoms require more carbon uptake than ... as CO 2 would react with water to produce carbonic acid. CO 2 + H 2 O ↽ − − ⇀ HCO 3 − + H + {\displaystyle {\ce {CO2 + H2O <=> ... p. 3. ISBN 978-0-472-06515-8. Huber, Norman King; Geological Survey (U.S.); United States. National Park Service (1975). The ... Retrieved December 3, 2007. "Divers find 1780 British warship". BBC News. June 14, 2008. Retrieved June 15, 2008. "L.R. Doty, ...
CcmM has two domains: an N-terminal gamma-carbonic anhydrase domain followed by a domain consisting of three to five repeats of ... Bicarbonate is pumped into the cytosol and diffuses into the carboxysome, where carbonic anhydrase converts it to carbon ... G. D. Price & M. R. Badger (October 1989). "Expression of Human Carbonic Anhydrase in the Cyanobacterium Synechococcus PCC7942 ... and carbonic anhydrase in carbon-fixing bacteria as part of a carbon concentrating mechanism. ...
... may refer to: Carbonic anhydrase III, muscle specific, a human gene Cornu Ammonis region 3, one of the hippocampal ... Caproni Ca.3, an Italian heavy bomber of World War I and the post-war era This disambiguation page lists articles associated ... Buhl-Verville CA-3 Airster Buhl CA-3 Airsedan CAC CA-3 Wirraway California's 3rd congressional district California State Route ...
CO2 is carried in blood in three different ways. (The exact percentages vary depending whether it is arterial or venous blood ... Oct-1-en-3-one ("Smell" of blood) Taboo food and drink: Blood "Definition of BLOOD". Archived from the original on 23 March ... This is derived from the statement in the Qur'an, sura Al-Ma'ida (5:3): "Forbidden to you (for food) are: dead meat, blood, the ... In Judaism, animal blood may not be consumed even in the smallest quantity (Leviticus 3:17 and elsewhere); this is reflected in ...
"Entrez Gene: CA9 carbonic anhydrase IX".. *^ Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E ... Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.[5][6][7] ... Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas". Digestive and Liver Disease. 33 (1): 68-74. ... Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. ...
One study found that the majority of capillaries in cherry hemangiomas are fenestrated and stain for carbonic anhydrase ... ISBN 978-0-323-37674-7. Eichhorn, M; Jungkunz, W; Wörl, J; Marsch, WC (1994). "Carbonic anhydrase is abundant in fenestrated ... 69 (3): 574-6. doi:10.1016/j.ecoenv.2007.01.003. PMID 17382390. Raymond, Lawrence W.; Williford, Linda S.; Burke, William A. ( ... 74 (1): 51-3. doi:10.2340/00015555745153 (inactive 2021-01-11). PMID 7908484.CS1 maint: DOI inactive as of January 2021 (link) ...
Carbonic anhydrase[edit]. Active site of carbonic anhydrase. The three coordinating histidine residues are shown in green, ... A reaction similar to this is almost instantaneous with carbonic anhydrase. The structure of the active site in carbonic ... Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi:10.1016/ ... It consists of a zinc ion coordinated by three imidazole nitrogen atoms from three histidine units. The fourth coordination ...
It is a highly active carbonic anhydrase inhibitor. The molecule contains a gallagic acid component linked to a glucose. Zhang ... It is also reported in Combretum glutinosum, all three species being Myrtales, the two last being Combretaceae. ... Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of ...
Casini, Angela (2004). "Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH". ... Gabbiani, Chiara; Casini, Angela; Messori, Luigi (2007-03-01). "Gold(III) compounds as anticancer drugs". Gold Bulletin. 40 (1 ... Casini, Angela (2004). "Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological ... "Carbonic anhydrase inhibitors". Medicinal Research Reviews. 23 (2): 146-189. doi:10.1002/med.10025. PMID 12500287. S2CID ...
Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J (Dec 2004). "Pepsin and carbonic anhydrase isoenzyme III as diagnostic ... Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist and fold, bringing together a small ... It is one of three principal proteases in the human digestive system, the other two being chymotrypsin and trypsin. During the ... 126 (3): 405-9. doi:10.1001/archotol.126.3.405. PMID 10722017.. *^ Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA (Aug ...
Carbonic anhydrase. *CO dehydrogenase [18]. *Cytochrome c peroxidase. *Fumarase. *Superoxide dismutase. *Triosephosphate ... In 1972, it was observed that in the dehydration of H2CO3 catalyzed by carbonic anhydrase, the second-order rate constant ... "H2CO3 as Substrate for Carbonic Anhydrase in the Dehydration of HCO3−". Proceedings of the National Academy of Sciences of the ... 3][4] According to their estimation,[3][4] the upper limit of enzyme-substrate reaction was 109 M−1 s−1. ...
Carbon dioxide (CO2) is carried in blood in three different ways. The exact percentages vary depending whether it is arterial ... 3 by the enzyme carbonic anhydrase in the red blood cells.[6] by the reaction CO2 + H2O → H2CO3 → H+ + HCO−. 3. ... In men, there are 5.4 million red blood cells per microliter of blood.[3] Red blood cells are red because they have hemoglobin ...
Gültepe, N; Ateş, O; Hisar, O (Sep 2011). "Carbonic anhydrase activities from the rainbow trout lens correspond to the ... Gas Bubble Disease may develop in three different stages: Pressure unequilibrium resulting in excess gas formation. Metabolic ... 25 (3): 284-288. PMID 9289892. Rucker, Robert R. (1972). Gas-bubble Disease of Salmonids: A Critical Review. Bureau of Sport ... 23 (3): 134-139. doi:10.1080/08997659.2011.616848. PMID 22216712. Hulst, Robert A. van; Klein, Jan; Lachmann, Burkhard (2003 ...
"Evidence for the Involvement of Carbonic Anhydrase and Urease in Calcium Carbonate Formation in the Gravity-Sensing Organ of ... Larva rapidly transform into juveniles with sexual maturity typically occurring within three and four months from birth. A. ... 19 (3): 449-462. doi:10.1007/s10646-010-0463-6. PMID 20130988. Dionísio, G.; Rui, R.; Leal, M.; Cruz, S.; Brandão, C.; Calado, ... 3: 6. doi:10.1186/1742-9994-3-6. PMC 1526719. PMID 16597345. Backeljau, T. (1986). Lijst van de recente mariene mollusken van ...
It is a highly active carbonic anhydrase inhibitor. In some plants including oak and chestnut, the ellagitannins are formed ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ... from 1,2,3,4,6-pentagalloyl-glucose and further elaborated via oxidative dehydrogenation (tellimagrandin II and casuarictin ...
Towards a model for inorganic carbon uptake in seagrasses involving carbonic anhydrase. In Kuo J, Phillips RC, Walker DI, ... Due to this three dimensional structure in the water column, many species occupy seagrass habitats for shelter and foraging. It ... Seagrasses are a paraphyletic group of marine angiosperms which evolved three to four times from land plants back to the sea. ... Ten seagrass species are at elevated risk of extinction (14% of all seagrass species) with three species qualifying as ...
Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. Chronic ... Effects generally begin within three hours and last for up to three days. Chlortalidone is more effective than ... Johnston MM, Li H, Mufson D (December 1977). "Chlorthalidone analysis using carbonic anhydrase inhibition". J Pharm Sci. 66 (12 ... it also strongly inhibits multiple isoforms of carbonic anhydrase. ...
... they contain a large number of copies of the enzyme carbonic anhydrase on the inside of their cell membrane. Carbonic anhydrase ... Karl Landsteiner published his discovery of the three main blood groups-A, B, and C (which he later renamed to O). Landsteiner ... The carbonic anhydrase in the red cells keeps the bicarbonate ion in equilibrium with carbon dioxide. So as carbon dioxide ... When it diffuses into a RBC, CO2 is rapidly converted by the carbonic anhydrase found on the inside of the RBC membrane into ...
Lutwak-Mann C, Adams CE (April 1957). "Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase ... to possess similar potency to progesterone and hydroxyprogesterone caproate in the rabbit endometrial carbonic anhydrase test, ... Progesterone 3-acetyl enol ether, also known as progesterone acetate,[1] as well as 3-acetoxypregna-3,5-dien-20-one, is a ... 8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-2,7,8,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate ...
... being bound to carbonic anhydrase II (CA II) like its parent steroidal sulfamate ester E2MATE and thus avoiding first pass ... Pharmacodynamic proof of concept was demonstrated with Irosustat effecting nearly complete STS inhibition at three doses, and ... "Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-Coumate, a novel anti-cancer agent". ... J. 385 (Pt 3): 715-720. doi:10.1042/BJ20041037. PMC 1134746. PMID 15453828. Carmen Avendano; J. Carlos Menendez (11 June 2015 ...
The enzyme carbonic anhydrase, which catalyzes this reaction, is named after this property of carbon dioxide. Chromium trioxide ... The oxides of period three elements demonstrate periodicity with respect to acidity. As one moves across the period, the oxides ... Carbon dioxide is the anhydride of carbonic acid: H 2 CO 3 ⟶ H 2 O + CO 2 {\displaystyle {\ce {H2CO3 -> H2O + CO2}}} ... For example, sulfurous acid (SO2), sulfuric acid (SO3), and carbonic acid (CO2) are acidic oxides. An inorganic anhydride (a ...
Gastrointestinal loss of bicarbonate (HCO− 3) Severe diarrhea (vomiting will tend to cause hypochloraemic alkalosis) Pancreatic ... 3 resorption Distal renal tubular acidosis with failure of H+ secretion Long-term use of a carbonic anhydrase inhibitor such as ... so that infusing more than 3-4L can cause acidosis Hyperalimentation (i.e., total parenteral nutrition) Anion gap Metabolic ...
... class III antiarrhythmic) Sotalol (β blocker) Tamsulosin (α blocker) Udenafil (PDE5 inhibitor) Brinzolamide (carbonic anhydrase ... anti-glaucoma carbonic anhydrase inhibitor) Probenecid (uricosuric) Sulfasalazine (anti-inflammatory agent and a DMARD) ... class III antiarrhythmic) Dronedarone (class III antiarrhythmic) Ibutilide ( ...
Carbonic anhydrase-related protein 10 is an enzyme that in humans is encoded by the CA10 gene. This gene encodes a protein that ... "Entrez Gene: CA10 carbonic anhydrase X". Human CA10 genome location and CA10 gene details page in the UCSC Genome Browser. ... The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a ... 2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain ...
Twenty-three percent of carbon dioxide is carried in blood this way (70% is converted into bicarbonate by carbonic anhydrase ...
... with combined features of proximal and distal RTA is due to mutation in the CA2 gene for carbonic anhydrase II. These ... They had three daughters, one of whom is the author and journalist Michela Wrong. Khositseth, S; Bruce LJ; Walsh SB; et al. ( ... It was further shown that there were three forms of recessive RTA distinguished clinically and on the basis of molecular ... 1996). "A common molecular basis for three inherited kidney stone diseases". Nature. 379 (6564): 445-449. Bibcode:1996Natur.379 ...
Carbonic anhydrase inhibitors may cause stinging, burning, and eye discomfort. Lubricant eye drops may cause some side effects ... Ophthalmologists recommend disposing of bottles no longer than three months after opening. Eye drops that contain no ... and carbonic anhydrase inhibitors. There are also combination drugs available for those patients who require more than one type ... Furthermore, when redness occurs but lasts more than 3 days, one should immediately consult a doctor.[citation needed] ...
Carbonic anhydrase isozyme CA3 protects cells against oxidative stress. Ectopic expression of murine Ca3, but not Ca2, protects ... Carbonic anhydrase III (CA3) is unique in this family as it has low hydratase activity [7] but it is very abundant in liver, ... Du, A.L., Ren, H.M., Lu, C.Z., Tu, J.L., Xu, C.F. and Sun, Y.A. (2009) Carbonic Anhydrase III Is Insufficient in Muscles of ... Dai, H.Y., Hong, C.C., Liang, S.C., Yan, M.D., Lai, G.M., Cheng, A.L. and Chuang, S.E. (2008) Carbonic Anhydrase III Promotes ...
Purified carbonic anhydrase isozymes I, II, and III (CA I, CA II, CA III) from various sources were treated with 2,3- ... Expression of carbonic anhydrase isozyme III in the ciliary processes and lens. Jampel, H.D., Chen, X., Chue, C., Zack, D.J. ... Serum myoglobin/carbonic anhydrase III ratio as a marker of reperfusion after myocardial infarction. Vuotikka, P., Uusimaa, P ... Dual-label time-resolved fluoroimmunoassay for simultaneous detection of myoglobin and carbonic anhydrase III in serum. Vuori, ...
Carbonic anhydrase 2. A. 259. Homo sapiens. Mutation(s): 0 Gene Names: CA2. EC: 4.2.1.1. ... Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide. *DOI: 10.2210/pdb3V7X/pdb ... A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase ... A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase ...
Mouse Monoclonal Anti-Carbonic Anhydrase III/CA3 Antibody (4A12-1A3). Validated: WB, ELISA, IHC-P. Tested Reactivity: Human. ... Additional Carbonic Anhydrase III/CA3 Products. Carbonic Anhydrase III/CA3 H00000761-M02 * Carbonic Anhydrase III/CA3 ... Home » Carbonic Anhydrase III/CA3 » Carbonic Anhydrase III/CA3 Antibodies » Carbonic Anhydrase III/CA3 Antibody (4A12-1A3) ... Blogs on Carbonic Anhydrase III/CA3. There are no specific blogs for Carbonic Anhydrase III/CA3, but you can read our latest ...
Carbonic anhydrase 2. A. 259. Homo sapiens. Mutation(s): 0 Gene Names: CA2. EC: 4.2.1.1. ... Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide. *DOI: 10.2210/pdb3VBD/ ... A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase ... A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase ...
Inhibition studies of physiologically relevant human carbonic anhydrase (CA, EC 4.2.1.1) isoforms, such as CA I, II, IX, XII ... 5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic ... The 1,3,5-triazinyl-substituted benzenesulfonamides constitute thus a class of compounds with great potential for obtaining ...
A series of potent inhibitors of human carbonic anhydrase (CA) isoforms I and II has been prepared via a direct, chemoselective ... Probing the bipolar nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as ... Carbonic anhydrase inhibitors; Chemoselective sulfochlorination; Drug discovery; Isoform selectivity ... Carbonic Anhydrase Inhibitors/chemical synthesis. *Carbonic Anhydrase Inhibitors/chemistry. *Carbonic Anhydrase Inhibitors/ ...
3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX ... BenzothiazolesCarbonic Anhydrase ICarbonic Anhydrase IICarbonic Anhydrase IXCarbonic Anhydrase InhibitorsCarbonic Anhydrases ... Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for ... Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms ...
Carbonic Anhydrases/metabolism ; Female ; Fructose/adverse effects/analogs & derivatives/therapeutic use ; Humans ; Kidney/drug ... Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. ... Reference : Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase.. ...
Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by ...
... and a significant reduction of carbonic anhydrase-III (CA-III) evident only in ethanol-fed rats. Ethanol feeding of rats for 8 ... Isoaspartate, Carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury ... Alcohol-induced liver injury; Carbamoyl phosphate synthase-1; Carbonic anhydrase-III; Isoaspartate; Liver proteome; Protein ... and carbonic anhydrase-III as biomarkers of liver injury. Biochemical and Biophysical Research Communications, 458 (3). pp. 626 ...
The platelet carbonic anhydrase II (CAII) was described for the first time in the 80s of the last century. Nevertheless, its ... Carbonic anhydrases constitute a group of enzymes that catalyse reversible hydration of carbon dioxide leading to the formation ... A.-L. Du, H.-M. Ren, C.-Z. Lu, J.-L. Tu, C.-F. Xu, and Y.-A. Sun, "Carbonic anhydrase III is insufficient in muscles of ... 2. Carbonic Anhydrase II. Carbonic anhydrase II (CAII) is a cytoplasmic enzyme with a very high affinity for sulphonamides and ...
Immunological study of human erythrocyte carbonic anhydrases]. by Hisashi Suyama et al. ... Erythrocyte carbonic anhydrase in humans and animals. 3. Immunological study of human erythrocyte carbonic anhydrases].. *. ... Erythrocyte carbonic anhydrase in humans and animals. 3. ...
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic ... Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients.. 19206230. 2009. Non-zinc mediated inhibition ... Anti-carbonic anhydrase III autoantibodies in vasculitis syndrome.. 23720494. 2013. Genome-wide association study identifies ... myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin ...
Human carbonic anhydrase III, molecular model. This enzyme catalyses the reversible hydration of carbon dioxide in muscle ... Human carbonic anhydrase III, molecular model. This enzyme catalyses the reversible hydration of carbon dioxide in muscle ...
Human carbonic anhydrase III, molecular model. This enzyme catalyses the reversible hydration of carbon dioxide in muscle ... carbonic anhydrase, carbonic anhydrase iii, cut out, cut outs, cut-out, cut-outs, cutout, cutouts, digitally generated, enzyme ... Caption: Human carbonic anhydrase III, molecular model. This enzyme catalyses the reversible hydration of carbon dioxide in ... human carbonic anhydrase iii, illustration, medical, medical illustration, medicine, model, molecular, molecular model, ...
Activation of carbonic anhydrase III by active-site modification Biochem Soc Trans (December, 1984) ... Activation of carbonic anhydrase III by phosphate Biochem Soc Trans (October, 1988) ... Active-site modification of chicken carbonic anhydrase III Biochem Soc Trans (December, 1988) ... Bicarbonate dehydration kinetics and sulphonamide inhibition of carbonic anhydrase isoenzymes W. RICHARD CHEGWIDDEN W. RICHARD ...
Carbonic Anhydrase III Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-08616). Carbonic Anhydrase III ... 3. Upload files that contain software or other material protected by intellectual property laws (or by rights of privacy of ... To compare product details, select up to 3 alternatives below and click Compare Selected. To add items to your basket, enter a ...
... where carbonic anhydrase catalyzes its hydration to carbonic acid (H2CO3). Carbonic acid then spontaneously dissociates to form ... The underlying properties creating the chloride shift are the presence of carbonic anhydrase within the RBCs but not the plasma ... Continuous process of carbonic acid dissociation and outflow of bicarbonate ions would eventually lead to a change of ... Inward movement of bicarbonate via the Band 3 exchanger allows carbonic anhydrase to convert it to CO2 for expiration. The ...
... have been demonstrated to physically and/or functionally interact with isoforms of carbonic anhydrase (CA) to form a transport ... monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase ... Transport metabolons with carbonic anhydrases. Joachim W. Deitmer1* and Holger M. Becker2 ... Becker, H. M., and Deitmer, J. W. (2007). Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO−3 ...
Carbonic Anhydrase. 4. Lysozome. 5. Prolactin. Section 5: Growth Factors. 1. Epidermal Growth Factor and Nerve Growth Factor ( ... 3. Actin and Myosin. 4. Gilial Fibrillary Acidic Proteins. Section 2: Tissue and Plasma Proteins. 1. Epithelial Membrane ... Section 3: Proteinase Inhibitor. 1. 1-Antitrypsin ( 1-AT). 2. 1-Antichymotrypsin ( 1-Ach). Section 4: Enzymes and Hormones. 1. ... 2. Carcinoembryonic Antigen (CEA). 3. Lactoferrin. 4. Involucrin. 5. S-100 Protein. 6. Laminin. ...
Carbonic anhydrase III Homo sapiens 0.984 CHEMBL1795167 Toll-like receptor 4 Mus musculus 0.945 ... Carbonic anhydrase XIII Mus musculus 0.792 CHEMBL4159 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein ... 3. ClinicalTrials. Multiple Sclerosis, Relapsing-Remitting. D020529. EFO:0003929. relapsing-remitting multiple sclerosis. 2. ...
... carbonic anhydrase (CA) enzyme, expressed mainly at the external surface of cells, that catalyzes reversible CO(2) hydration. ... Antigens, Neoplasm, Apoptosis, Carbon Dioxide, Carbonic Anhydrase IX, Carbonic Anhydrases, Cell Line, Tumor, Cell Membrane, ... Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. ... Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. ...
8.9±3.5). mRNA concentrations of HIF-1α (+55%), carbonic anhydrase III (+35%) and monocarboxylate transporter-4 (+20%) were ... carbonic anhydrase III; MCT-1, monocarboxylate transporter-1; MCT-4, monocarboxylate transporter-4; LDH, lactate dehydrogenase. ... Figure 3. Average power output (W) in successive sprints during the repeated sprint test before (Pre-) and after (Post-) the ...
H2O2 and peroxyl radicals both gener- ated S-glutathiolated carbonic anhydrase III via par- tially oxidized protein sulfhydryl ... In cultured rat hepatocytes, carbonic anhydrase III was rapidly S-glutathiolated by mena- dione. When hepatocyte glutathione ... Indeed, both total protein extracts and carbonic anhydrase III contained significantly more cysteine sulfinic acid in older ... of carbonic anhydrase III if glutathione (GSH) was not present. When GSH was approximate- ly equimolar to protein thiols, ...
"Assignment of the gene determining human carbonic anhydrase, CAI, to chromosome 8, Annals of Human Genetics" on DeepDyve, the ... Characterization of human carbonic anhydrase III from skeletal muscle. Carter, Carter; Jeffery, Jeffery; Shiels, Shiels; ... The gene for human muscle specific carbonic anhydrase (CA III) is assigned to chromosome 8 ... Isolation of a cDNA clone for the human muscle specific carbonic anhydrase, CA III ...
... carbonic anhydrase 3 (CA3); creatine kinase M-type (CKM); enolase (fragment) (ENO3); fatty acid binding-protein, heart (FABP3 ... Figure 4. Representation of protein abundance index decreasing (A) and increasing (B) during the three extraction procedures (i ... Figure 4. Representation of protein abundance index decreasing (A) and increasing (B) during the three extraction procedures (i ... These revealed three groups: the first one corresponded to the proteins showing a decreasing abundance index during the ...
... and myomesin family member 3, were responsible for the development and contraction of muscle. Real-time PCR analysis indicated ... X. Shang, S. Chen, H. Ren, Y. Li, and H. Huang, "Carbonic anhydrase III: the new hope for the elimination of exercise-induced ... R. P. Henry, "Multiple roles of carbonic anhydrase in cellular transport and metabolism," Annual Review of Physiology, vol. 58 ... Carbonic anhydrase 3 (Car3), is upregulated more than 2-fold. Car3 plays multiple important biological activities such as ...
as fluorescent photoaffinity probes for human carbonic anhydrase II capture Partha Sarathi Addy, Baisakhee Saha, N. D. Pradeep ... 5-trisubstituted benzenes for photo-mediated capture of human carbonic anhydrase II with visualisation by fluorescence is ... Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for ... Transannular iodoamination of substituted 1,2,3,4,7,8-hexahydroazocines facilitates the asymmetric synthesis of ...
1993) Refined structure of bovine carbonic anhydrase III at 2.0 Å resolution. Proteins Struct Funct Genet 16:29-42. ... 1975) Crystal structure of human carbonic anhydrase B: three-dimensional structure at a nominal 2.2 Å resolution. Proc Natl ... Intracellular β-Carbonic Anhydrase of the Unicellular Green Alga Coccomyxa Thomas Hiltonen, Harry Björkbacka, Cecilia Forsman, ... Intracellular β-Carbonic Anhydrase of the Unicellular Green Alga Coccomyxa Thomas Hiltonen, Harry Björkbacka, Cecilia Forsman, ...
  • Carbonic anhydrases constitute a group of enzymes that catalyse reversible hydration of carbon dioxide leading to the formation of bicarbonate and proton. (hindawi.com)
  • Carbonic acid then spontaneously dissociates to form bicarbonate Ions (HCO3−) and a hydrogen ion (H+). (wikipedia.org)
  • H+, HCO3− ) but RBCs are able to exchange bicarbonate for chloride using the anion exchanger protein Band 3. (wikipedia.org)
  • Inward movement of bicarbonate via the Band 3 exchanger allows carbonic anhydrase to convert it to CO2 for expiration. (wikipedia.org)
  • The underlying properties creating the chloride shift are the presence of carbonic anhydrase within the RBCs but not the plasma, and the permeability of the RBC membrane to carbon dioxide and bicarbonate ion but not to hydrogen ion. (wikipedia.org)
  • Continuous process of carbonic acid dissociation and outflow of bicarbonate ions would eventually lead to a change of intracellular electric potential because of lasting H+ ions. (wikipedia.org)
  • To overcome the inefficiency of RuBisCO, carboxysomes concentrate carbon dioxide inside the shell by means of co-localized carbonic anhydrase activity, which produces carbon dioxide from the bicarbonate that diffuses into the carboxysome. (wikipedia.org)
  • The GDPSP/C was dependent on the availability of bicarbonate, but not on interstitial or intrapyramidal carbonic anhydrase activity. (jneurosci.org)
  • 3. A process as claimed in claim 2 , wherein said hydration of step b) is catalysed by means of an enzyme capable of catalysing the hydration of dissolved CO 2 into hydrogen ions and bicarbonate ions. (google.es)
  • During an episode, people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base balance in the blood (metabolic acidosis and respiratory alkalosis), low glucose in the blood (hypoglycemia), and reduced production of a substance called bicarbonate in the liver. (medlineplus.gov)
  • This gene provides instructions for making the carbonic anhydrase VA enzyme, which helps convert carbon dioxide to a substance called bicarbonate. (medlineplus.gov)
  • The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes in the energy-producing centers of cells (mitochondria). (medlineplus.gov)
  • Mutations in the CA5A gene result in absent or impaired carbonic anhydrase VA enzyme function, leading to reduced bicarbonate production. (medlineplus.gov)
  • Insufficient bicarbonate results in impaired control of acid-base balance and reduces the activity of the four affected mitochondrial enzymes, resulting in the various biochemical abnormalities associated with carbonic anhydrase VA deficiency. (medlineplus.gov)
  • The carbonic anhydrases (or carbonate dehydratases ) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions ). (wikipedia.org)
  • Carbonic acid has a pK a of around 6.36 (the exact value depends on the medium) so at pH 7 a small percentage of the bicarbonate is protonated. (wikipedia.org)
  • In the lungs carbonic anhydrase converts bicarbonate to carbon dioxide, suited for exhalation. (wikipedia.org)
  • In C 4 photosynthesis, the enzyme carbonic anhydrase (CA) hydrates CO 2 to form bicarbonate, which is the first catalyzed step in the C 4 photosynthetic pathway ( Badger, 1994 ). (plantphysiol.org)
  • The several distinct classes of this enzyme (α, β, γ etc.) share little similarity in terms of structure and sequence, but they all perform the same function of catalyzing the hydration of carbon dioxide and the dehydration of bicarbonate [3]. (libretexts.org)
  • Hence, by assisting the inter-conversion between carbon dioxide and bicarbonate, Carbonic anhydrase B helps to maintain acid-base balance in blood, and transport carbon dioxide out of blood. (libretexts.org)
  • A series of arylsulfonamides has been synthesized and investigated for the inhibition of some selected human carbonic anhydrase isoforms. (rcsb.org)
  • Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. (nih.gov)
  • Inhibition studies of physiologically relevant human carbonic anhydrase (CA, EC 4.2.1.1) isoforms, such as CA I, II, IX, XII and XIV with these compounds are reported. (nih.gov)
  • A series of potent inhibitors of human carbonic anhydrase (CA) isoforms I and II has been prepared via a direct, chemoselective sulfochlorination of a range of 1,3-oxazolyl benzenes and thiophenes, followed by primary sulfonamide synthesis. (nih.gov)
  • TY - JOUR T1 - 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII. (unboundmedicine.com)
  • There are 15 carbonic anhydrase isoforms in humans (belonging to the α subgroup) [ 5 ]. (hindawi.com)
  • Band3), the Na + /H + exchanger NHE1, the Na + /HCO − 3 cotransporter NBCe1, and various monocarboxylate transporters (MCTs) have been demonstrated to physically and/or functionally interact with isoforms of carbonic anhydrase (CA) to form a "transport metabolon. (frontiersin.org)
  • Several carbonic anhydrase (CA) isoforms are associated with plasma membranes. (physiology.org)
  • There are three additional "acatalytic" CA isoforms (CA-VIII, CA-X, and CA-XI) ( CA8 , CA10 , CA11 ) whose functions remain unclear. (wikipedia.org)
  • The 1,3,5-triazinyl-substituted benzenesulfonamides constitute thus a class of compounds with great potential for obtaining inhibitors targeting both α-class mammalian, tumor-associated, and β-class from pathogenic organisms CAs. (nih.gov)
  • Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors. (nih.gov)
  • Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. (nih.gov)
  • Mercury in PDB 3b4f: Carbonic Anhydrase Inhibitors. (atomistry.com)
  • Enzymatic activity of Carbonic Anhydrase Inhibitors. (atomistry.com)
  • The binding sites of Mercury atom in the Carbonic Anhydrase Inhibitors. (atomistry.com)
  • Mercury binding site 1 out of 1 in the Carbonic Anhydrase Inhibitors. (atomistry.com)
  • The Pf values for AQP1 cRNA injected oocytes in the presence of acetazolamide and two other CA inhibitors, AL-5733A and AL-6950 were 144 +/- 37 (p = 0.0143), 111 +/- 3 (p = 0.0015) and 83 +/- 12 (p = 0.0006), respectively. (arvojournals.org)
  • Water permeability of AQP1 cRNA injected oocytes was inhibited by three different carbonic anhydrase inhibitors. (arvojournals.org)
  • These three compounds share some features important for both CA and AQP1 inhibition suggesting that these inhibitors may play a role in IOP regulation partly by modulating water flow via AQP1 channel. (arvojournals.org)
  • Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. (expasy.org)
  • Generally carbonic anhydrase inhibitors are used to treat epilepsy , glaucoma , mountain sickness, and is used as a diuretic. (drugs.com)
  • These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. (novusbio.com)
  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. (wikipedia.org)
  • The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. (sigmaaldrich.com)
  • Carbonicanhydrase is a group of enzymes that catalyze the hydration and hydrolysis of many carbonyl and related systems, such as hydration of carbon dioxide and aldehydes, and hydrolysis of esters [1] . (libretexts.org)
  • Carbonic anhydrase III (CA3) is unique in this family as it has low hydratase activity [7] but it is very abundant in liver, skeletal muscle and adipose tissue. (scirp.org)
  • Immunohistochemistry-Paraffin: Carbonic Anhydrase III/CA3 Antibody (4A12-1A3) [H00000761-M02] - Analysis of monoclonal antibody to CA3 on formalin-fixed paraffin-embedded human skeletal muscle. (novusbio.com)
  • The carbonic anhydrase CA3 isoform displayed an increased abundance during muscle aging, which was independently verified by immunoblotting of differently aged human skeletal muscle samples. (nih.gov)
  • Mass spectrometry-based proteomic analysis of middle-aged vs. aged vastus lateralis reveals increased levels of carbonic anhydrase isoform 3 in senescent human skeletal muscle. (nih.gov)
  • Streptozotocin-induced diabetes mellitus resulted in a reduction in acetazolamide-resistant activity of carbonic anhydrase in the liver, but not in tonic skeletal muscle, of adult male rats. (biochemj.org)
  • Western Blot: Carbonic Anhydrase III/CA3 Antibody (4A12-1A3) [H00000761-M02] - CA3 monoclonal antibody (M02), clone 4A12-1A3 Analysis of CA3 expression in K-562. (novusbio.com)
  • Sandwich ELISA: Carbonic Anhydrase III/CA3 Antibody (4A12-1A3) [H00000761-M02] - Detection limit for recombinant GST tagged CA3 is approximately 1ng/ml as a capture antibody. (novusbio.com)
  • Girentuximab , an antibody to carbonic anhydrase IX, is an investigational agent in clinical trials for renal cell carcinoma . (wikipedia.org)
  • The following product was used in this experiment: Carbonic Anhydrase VI Monoclonal Antibody (401809) from Thermo Fisher Scientific, catalog # MA5-24136, RRID AB_2609157. (thermofisher.com)
  • Three major protein bands of ~75-80 kDa, ~95-100 kDa, and ~155-160 kDa were identified by autoradiography. (nottingham.ac.uk)
  • H2O2 and peroxyl radicals both gener- ated S-glutathiolated carbonic anhydrase III via par- tially oxidized protein sulfhydryl intermediates, while HOCl did not cause S-glutathiolation. (iastate.edu)
  • Indeed, both total protein extracts and carbonic anhydrase III contained significantly more cysteine sulfinic acid in older rats compared to young animals. (iastate.edu)
  • The most enriched category was muscular system, and 6 upregulated genes, such as troponin I, troponin T1, cysteine and glycine-rich protein 2, myosin heavy polypeptide 7, tropomyosin 2, and myomesin family member 3, were responsible for the development and contraction of muscle. (hindawi.com)
  • Carboxysomes are bacterial microcompartments (BMCs) consisting of polyhedral protein shells filled with the enzymes ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO)-the predominant enzyme in carbon fixation and the rate limiting enzyme in the Calvin cycle-and carbonic anhydrase. (wikipedia.org)
  • The carboxysome has an outer shell composed of a few thousand protein subunits, which encapsulates a CO2-producing enzyme (carbonic anhydrase) and a carbon-fixing enzyme (RuBisCO). (wikipedia.org)
  • iii) dependent on both TCDD exposure and strain ( e.g. oxidative stress-related proteins, apoptosis-inducing factor, and MAWD-binding protein). (mcponline.org)
  • Maturational studies showed that the expression of CA IX mRNA and protein increased markedly with weaning (∼3-4 postnatal wk) and was well correlated with the maturational expression of the α-subunit of the gastric H + ,K + -ATPase, suggesting that function of CA IX and the gastric H + pump might be linked in the digestion of adult foodstuffs. (physiology.org)
  • CAIX is a transmembrane protein and is a tumor-associated carbonic anhydrase isoenzyme. (wikipedia.org)
  • In every living organism, the protein family of carbonic anhydrases regulate a broad variety of homeostatic processes. (biomedsearch.com)
  • CA5B (Carbonic Anhydrase 5B) is a Protein Coding gene. (genecards.org)
  • Hydrogen (H)-bonds are ubiquitous in nature and play an important role in protein folding ( 1 ), protein-ligand interactions ( 2 ), and catalysis ( 3 , 4 ). (sciencemag.org)
  • The protein encoded by this gene is one of several isozymes of carbonic anhydrase. (thermofisher.com)
  • Like all other forms of carbonic anhydrase, CA B. consists of protein and one zinc ion at the bottom of the active site near the center of the molecule [1]. (libretexts.org)
  • 1). Geometry of the metal: The metal is liganded to the protein by three histidyl ligands, and the fourth ligand site is open to surrounding medium and possibly filled by a water molecule or OH ion. (libretexts.org)
  • Carbonic anhydrases constitute a group of zinc containing lyases, classified, according to the Enzyme Catalogue to EC 4.2.1.1. (hindawi.com)
  • Data show that inserting histidine residues into the active site cavity of carbonic anhydrase II or III results in rates of proton transfer to the zinc-bound hydroxide that are antagonistic or suppressive with respect to the corresponding single mutants. (nih.gov)
  • CA (EC 4.2.1.1) is a zinc-containing enzyme that catalyzes the reversible reaction CO 2 + H 2 O ↔ HCO 3 − + H + . CA is widely distributed throughout nature, from eukaryotes such as vertebrates, invertebrates, and plants, to prokaryotes such as archaeabacteria and eubacteria. (plantphysiol.org)
  • The native molecular masses of CAs from C 3 dicot plants have been reported to vary between 140 and 250 kD, with a subunit mass of 26 to 34 kD, each binding one zinc ion ( Reed and Graham, 1981 ). (plantphysiol.org)
  • Carbonic anhydrases (CA) are zinc metalloenzymes that are present in prokaryotes and eukaryotes. (biomedsearch.com)
  • Close-up rendering of active site of human carbonic anhydrase II, showing three histidine residues and a hydroxide group coordinating (dashed lines) the zinc ion at center. (wikipedia.org)
  • A zinc prosthetic group in the enzyme is coordinated in three positions by histidine side-chains . (wikipedia.org)
  • Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. (sigmaaldrich.com)
  • In addition, three different clusters of aromatic residues of about same distance from the zinc ion have been observed in the molecule. (libretexts.org)
  • Experiments have shown that the activity of carbonic anhydrase B can be restored when zinc ions are added in 1:1 molar ratio. (libretexts.org)
  • 3) Model complexes of zinc enzymes have been synthesized by using several surfactants containing imidazole ligands, and their catalytic functions have been examined in ester hybrolysis. (nii.ac.jp)
  • Such an air-lock, in contrast to BMC-H proteins with constitutively open pores, has been suggested to serve as a route for larger substrates (ribulose-1,5-bisphosphate) and products (3-phosphoglycerate) that must cross the shell. (wikipedia.org)
  • Three different proteins were selected for detailed study-CD4, ERO1, and AKT. (frontiersin.org)
  • Three proteins including carbonic anhydrase 6, cystatin C, and cystatin SN were found to be the same as previous study. (rti.org)
  • In 1983, we reported a deficiency of carbonic anhydrase II, one of the isozymes of carbonic anhydrase, in three sisters with this disorder. (nih.gov)
  • Maturation of hemodynamic responses correlated with age-dependent increases in susceptibility to inhibition of carbonic anhydrase. (nature.com)
  • Carbonic anhydrase isozyme CA3 protects cells against oxidative stress. (scirp.org)
  • Virtual absence of the carbonic anhydrase II peak on high-performance liquid chromatography, of the esterase and carbon dioxide hydratase activities of carbonic anhydrase II, and of immunoprecipitable isozyme II was demonstrated on extracts of erythrocyte hemolysates from all patients studied. (nih.gov)
  • It dissolves in the solution of blood plasma and into red blood cells (RBC), where carbonic anhydrase catalyzes its hydration to carbonic acid (H2CO3). (wikipedia.org)
  • Hydrogen peroxide (H2O2), peroxy radicals, or hypochlorous acid (HOCl) produced irreversibly oxidized forms, primarily cysteine sulfinic acid or cys- teic acid, of carbonic anhydrase III if glutathione (GSH) was not present. (iastate.edu)
  • carbonic anhydrase (ca) catalyzes the reversible hydration of CO 2 and dehydration of carbonic acid. (physiology.org)
  • The risk or severity of adverse effects can be increased when 3-Hydroxyhippuric acid is combined with Sulpiride. (drugbank.ca)
  • Sequential oxidation of Cys thiols yields sulfenic (-SOH), sulfinic (-SO 2 H), or sulfonic (-SO 3 H) acid derivatives. (frontiersin.org)
  • The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. (cathdb.info)
  • Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. (biomedsearch.com)
  • What are the 3 fundamental components of the acid base system? (brainscape.com)
  • Investigations into how carbonic anhydrase, hensin, galectin - 3 and cyclophilins influence the kidney's response to acid-base disorders. (rochester.edu)
  • For example, carbonic anhydrase produces acid in the stomach lining. (wikipedia.org)
  • An anhydrase is defined as an enzyme that catalyzes the removal of a water molecule from a compound, and so it is this "reverse" reaction that gives carbonic anhydrase its name, because it removes a water molecule from carbonic acid. (wikipedia.org)
  • Because the triggers he listed for his symptoms suggested a disorder of fatty acid β-oxidation, an acylcarnitine profile was performed, which was suggestive of long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. (cmaj.ca)
  • Note that the carbonic acid (H 2 CO 3 ) and hydrogen carbonate ions (HCO 3 - ) is an important buffer system in the body. (libretexts.org)
  • Earlier reports have claimed that acetazolamide, a carbonic anhydrase (CA) inhibitor, inhibits AQP1 activity. (arvojournals.org)
  • In mice injected with high BCL3-expressing human gliomas, the carbonic anhydrase II inhibitor acetazolamide increased sensitivity to TMZ and survival in the mouse xenograft model. (sciencemag.org)
  • Our data suggest that BCL-3 might be a useful indicator of glioma response to alkylating chemotherapy and that acetazolamide might be repurposed as a chemosensitizer for treating TMZ-resistant gliomas. (sciencemag.org)
  • The enzyme is classified into three independent CA gene families designated α, β, and γ ( Hewett-Emmett and Tashian, 1996 ). (plantphysiol.org)
  • Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene . (wikipedia.org)
  • This gene encodes carbonic anhydrase 5B. (genecards.org)
  • A carbonic anhydrase pseudogene (CA5BP1) is adjacent to the CA5B gene and these two loci produce CA5BP1-CA5B readthrough transcripts. (genecards.org)
  • Carbonic anhydrase VA deficiency is caused by mutations in the CA5A gene. (medlineplus.gov)
  • Studies suggest that a related enzyme produced from the CA5B gene may increasingly compensate for the lack of carbonic anhydrase VA as affected individuals mature, which may result in a reduced risk of metabolic crisis and acute encephalopathy after childhood. (medlineplus.gov)
  • The generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other. (nih.gov)
  • Carbonic anhydrase (CA) (EC 4.2.1.1) enzymes catalyze the reversible hydration of CO 2 , a reaction that is important in many physiological processes. (plantphysiol.org)
  • It is probable that these enzymes interact with anion transporters to facilitate the movement of HCO 3 − into or out of the cell. (physiology.org)
  • Carbonic anhydrase is one of the fastest enzymes, and its rate is typically limited by the diffusion rate of its substrates . (wikipedia.org)
  • The research project on 'Development of Chemical Functions of Enzymes' has been carried out from the viewpoints of i) construction and application of enzyme and coenzyme model systems, ii) design of highly efficient molecular recognition sites, iii) synthesis and application of biologically important metal complexes, exes, and iv) development of regulatory compounds in biological systems. (nii.ac.jp)
  • Carbon dioxide (CO 2 ) is carried in blood in three different ways. (wikipedia.org)
  • Because the carbon-concentrating mechanism of C 4 species enables a lower intercellular CO 2 concentration compared with C 3 plants with typically greater photosynthetic efficiency ( von Caemmerer, 2000 ), it is possible that stomata of C 4 plants are not as sensitive to changes in CO 2 conditions. (plantphysiol.org)
  • One of the four discrete isoenzymes of carbonic anhydrase hitherto characterized, CA III, has the lowest turnover rate and the greatest resistance to inhibition by sulphonamides. (biochemj.org)
  • Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. (novusbio.com)
  • Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. (nih.gov)
  • Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients. (nih.gov)
  • The carbonic anhydrase VA deficiency may present as early-onset liver failure with hyperammonemia, hyperlactatemia, and ketonuria [ 13 ]. (hindawi.com)
  • These observations demonstrate the generality of the findings that we reported earlier in one family and provide further evidence that a deficiency of carbonic anhydrase II is the enzymatic basis for the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. (nih.gov)
  • We also summarize the clinical findings in these families, propose mechanisms by which a deficiency of carbonic anhydrase II could produce this metabolic disorder of bone, kidney, and brain, and discuss the clinical evidence for genetic heterogeneity in patients from different kindreds with this inborn error of metabolism. (nih.gov)
  • Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain substances in the body is disrupted (known as metabolic crisis) and brain function is abnormal (known as acute encephalopathy). (medlineplus.gov)
  • People with carbonic anhydrase VA deficiency typically first experience episodes of the disorder by age 2. (medlineplus.gov)
  • Between episodes, children with carbonic anhydrase VA deficiency are generally healthy, and more than half have no further episodes after the first one. (medlineplus.gov)
  • Because of the small number of people with carbonic anhydrase VA deficiency who have come to medical attention, the effects of this disorder in adults are not well understood. (medlineplus.gov)
  • The prevalence of carbonic anhydrase VA deficiency is unknown. (medlineplus.gov)
  • researchers suspect that some babies diagnosed with transient hyperammonemia may actually have carbonic anhydrase VA deficiency. (medlineplus.gov)
  • Interestingly, the autoantibodies against carbonic anhydrase II might be produced in humans due to cross-reactivity with carbonic anhydrase of Helicobacter pylori [ 28 ]. (hindawi.com)
  • Carbonic anhydrase (CA) catalyzes the hydration of CO 2 , and its activity has been linked to stomatal aperture regulation in eudicots. (plantphysiol.org)
  • Analysis of the liver proteome of 4-week ethanol-fed rats and PIMT KO mice demonstrated elevated cytosolic CPS-1 and betaine homocysteine S-methyltransferase-1 when compared to their respective controls, and a significant reduction of carbonic anhydrase-III (CA-III) evident only in ethanol-fed rats. (nottingham.ac.uk)
  • Fat accumulation in the liver, pancreas, and abdomen may have long-term, adverse metabolic consequences ( 1 - 3 ). (diabetesjournals.org)
  • We investigated the involvement of the class III deacetylase sirtuin [silent information regulator 1 (SIRT1)] in HSC activation and liver fibrosis. (medworm.com)
  • Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. (ox.ac.uk)
  • The secreted -protons, which are derived from the intracellular hydration of CO2 by carbonic anhydrase, are pumped out by an (H+ k+) ATPase antiport transporter is also required to complete the overall transport system. (biology-online.org)
  • Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist and fold, bringing together a small number of amino acids to form the active site, or the location on the enzyme where the substrate binds and the reaction takes place. (wikipedia.org)
  • feeding liquid H 20 and said at least portion of the extracted gaseous CO 2 into a bioreactor containing therein a reaction chamber filled with said carbonic anhydrase. (google.es)
  • and ( iii ) carbonic anhydrase reaction inside CE (Fig.1b). (arvojournals.org)
  • M1 results are of the same order of magnitude as experimental data, thereby providing evidence that the Cl - -HCO 3 - and Na + -H + antiporters on the S-CE membrane, the Cl - -HCO 3 - antiporter on the CE-P membrane, and the carbonic anhydrase reaction play a crucial role in determining the CE electro-chemical conditions. (arvojournals.org)
  • b) Write a reaction catalysed by the carbonic anhydrase enzyme. (biology-online.org)
  • Also known as Alpha carbonic anhydrase 1, chloroplastic (AtaCA1) (AtalphaCA1) (Alpha carbonate dehydratase 1). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 2 (AtaCA2) (AtalphaCA2) (Alpha carbonate dehydratase 2). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 3 (AtaCA3) (AtalphaCA3) (Alpha carbonate dehydratase 3). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 4 (AtaCA4) (AtalphaCA4) (Alpha carbonate dehydratase 4). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 5 (AtaCA5) (AtalphaCA5) (Alpha carbonate dehydratase 5). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 6 (AtaCA6) (AtalphaCA6) (Alpha carbonate dehydratase 6). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 7 (AtaCA7) (AtalphaCA7) (Alpha carbonate dehydratase 7). (mybiosource.com)
  • Also known as Alpha carbonic anhydrase 8 (AtaCA8) (AtalphaCA8) (Alpha carbonate dehydratase 8). (mybiosource.com)
  • 3. The method of claim 1 in which said preformed polymer leaving groups comprise hydrogen. (google.com)
  • Encodes an alpha carbonic anhydrase (CAH1) located in the chloroplast stroma. (mybiosource.com)
  • Human carbonic anhydrase III, molecular model. (sciencephoto.com)
  • Is carbonic anhydrase IX a validated target for molecular imaging of cancer and hypoxia? (wikipedia.org)
  • Evaluation of the risk posed by TCDD to humans is hampered by exceptionally large inter- and intraspecies variability both in wild animals and in laboratory species (for a review, see Ref. 3 ). (mcponline.org)
  • Research investigating stomatal movement has mostly been conducted in C 3 eudicot species, which have very different CO 2 requirements for photosynthesis relative to C 4 grasses. (plantphysiol.org)
  • Thus, it is likely that stomatal CO 2 -sensing and -signaling mechanisms differ between grasses and other species or between C 3 and C 4 plants. (plantphysiol.org)
  • 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) 1 is considered to be one of the most potent toxicants known and is the prototypical representative of the polyhalogenated aromatic hydrocarbon class of persistent environmental contaminants. (mcponline.org)
  • The effectiveness of carbonic anhydrase may be also altered by autoantibodies. (hindawi.com)
  • demonstrated in 1991 that anti-carbonic anhydrase autoantibodies (aCAAs) are present in serum of 32% patients with systemic lupus erythematosus, in 21% of patients with Sjögren's syndrome, but not in healthy volunteers. (hindawi.com)
  • Moreover, autoantibodies against carbonic anhydrase II were proved to play an important role in pathogenesis of retinopathy [ 25 ] and these against CAVI seem to induce dry eye syndrome in Sjögren's syndrome [ 26 , 27 ]. (hindawi.com)
  • Anti-carbonic anhydrase III autoantibodies in vasculitis syndrome. (nih.gov)
  • Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure. (nih.gov)
  • The KRONUS 3-Screen Islet Cell Autoantibody ELISA Assay Kit is for the simultaneous and nondifferential detection of GAD and/ or IA-2 and/or ZnT8 autoantibodies in human serum. (thefreedictionary.com)
  • Carbonic anhydrase inhibitor anticonvulsants inhibit the enzyme carbonic anhydrase. (drugs.com)
  • essential for in vitro carbonic anhydrase inhibitory activity and for diuresis in vivo. (flashcardmachine.com)
  • Engineering the hydrophobic pocket of carbonic anhydrase II. (cathdb.info)
  • Together with published mapping data, this assignment indicates that three CA loci are situated on chromosome 8. (deepdyve.com)
  • Here we describe the identification, mapping and cloning of a zebrafish carbonic anhydrase 5 (ca5) mutation, collapse of fins (cof), which causes initially a collapse of the medial fins followed by necrosis and rapid degeneration of the embryo. (biomedsearch.com)
  • Erythrocyte carbonic anhydrase in humans and animals. (semanticscholar.org)
  • 3. Immunological study of human erythrocyte carbonic anhydrases]. (semanticscholar.org)
  • BUTTERWORTH, P.H.W. 1986-05-01 00:00:00 Summary A cDNA clone complementary to the mRNA encoding the rabbit erythrocyte specific carbonic anhydrase, CAI, has been used as probe for human CAI sequences in the analysis of DNA from panels of rodent/human somatic cell hybrids. (deepdyve.com)
  • Human Erythrocyte Carbonic Anhydrase B. (libretexts.org)
  • Human erythrocyte Carbonic anhydrase (CA) B is a type of α-CA that is present in the blood [2]. (libretexts.org)
  • Crystal Structure of Human Erythrocyte Carbonic Anhydrase B. Three-Dimensional Structure at a Nominal 2.2-A Resolution. (libretexts.org)
  • Collectively, our results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury. (nottingham.ac.uk)
  • myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. (nih.gov)
  • Topiramate induces type 3 renal tubular acidosis by inhibiting renal carbonic anhydrase. (ac.be)