A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They play an important role in the transport of CARBON DIOXIDE from the tissues to the LUNG. EC 4.2.1.1.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Tumors or cancers of the KIDNEY.
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. Deficiencies of carbonic anhydrase II produce a syndrome characterized by OSTEOPETROSIS, renal tubular acidosis (ACIDOSIS, RENAL TUBULAR) and cerebral calcification. EC 4.2.1.-
A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.
A genus of gram-negative, ellipsoidal or rod-shaped bacteria whose major source of energy and reducing power is from the oxidation of ammonia to nitrite. Its species occur in soils, oceans, lakes, rivers, and sewage disposal systems.
The type species of the genus NITROSOMONAS, a gram-negative chemolithotroph that oxidizes ammonia to nitrite. It is found in soil, sewage, freshwater, and on building walls, and especially in polluted areas where air contains high levels of nitrogen compounds.
A white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial cells, and the gastrointestinal mucosa. EC 4.2.1.-
A membrane-bound carbonic anhydrase found in lung capillaries and kidney.
Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).
A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
A carbonic anhydrase isoenzyme found in MITOCHONDRIA where it provides bicarbonate ions that are components in the urea cycle and in GLUCONEOGENESIS.

Low-avidity antibodies to carbonic anhydrase-I and -II in autoimmune chronic pancreatitis. (1/32)

Antibodies (Abs) to carbonic anhydrase (isoforms CA-I and CA-II) have been considered pathogenic factors in the development of autoimmune pancreatitis. Besides, such autoAbs might accelerate the pancreatic damage in alcoholic chronic pancreatitis (CP). The aim of the present study was to evaluate the presence of serum Abs to CA-I and CA-II in CP and the relative affinity of these Abs. Serum anti-CA-I and -CA-II Abs were measured in 89 patients with CP (48 alcoholic and 41 nonalcoholic) by an ELISA technique. The prevalence of those autoAbs in CP was compared with other autoimmune diseases where they have also been found. The presence of other serological manifestations of autoimmunity, such as hypergammaglobulinemia or antinuclear Abs, was determined in CP patients as well. Elevated serum levels of both anti-CA-I (24%) and -CA-II (18%) Abs were observed in CP, although their prevalence was lower than in autoimmune diseases like rheumatoid arthritis (44 and 25%, respectively) or systemic lupus erythematosus (39% for anti-CA-I Abs). Furthermore, these Abs were of low average avidity. On the other hand, a significantly higher proportion of nonalcoholic CP had anti-CA-II Abs with respect to alcoholic CP (15.2 vs. 2.4%, p < 0.05). Anti-CA-I and -CA-II Abs might be helpful in the diagnosis of autoimmune CP, and the detection of the latter Abs seems to discard alcoholic etiology. Although it does not discard any pathogenic role in autoimmune CP, the low-avidity of anti-CA Abs argues against such idea.  (+info)

Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments. (2/32)

Dunaliella salina is a unicellular green alga thriving in environments ranging from fresh water to hyper-saline lakes, such as the Dead Sea. An unusual, internally duplicated, 60 kDa alpha-type carbonic anhydrase (dCA I), located on the surface of this alga, is expected to function over a broad range of salinities. It would therefore differ from other carbonic anhydrases that already lose activity at low salinities and also from halophilic proteins that require high salinities for conformational stability. Enzymatic analyses indeed indicated that dCA I retained activity at salt concentrations ranging from low salt to at least 1.5 M NaCl or KCl for CO(2) hydration, 2.0 M NaCl for esterase activity and 0.5 M for bicarbonate dehydration. Although measurements at higher salinities were constrained by the interference of salt in the respective assayed reactions, activity was noticeable even at 4.0 M NaCl. Comparisons of the internally duplicated dCA I to single-domain derivatives indicated that inter-domain interactions played a decisive role in the stability, activity, salt tolerance and pH responses of dCA I. Hence dCA I is a uniquely salt- tolerant protein, retaining an active conformation over a large range of salinities and, as a Zn metalloenzyme, largely immune to the specific inhibitory effects of anions. Its unique features make dCA I a useful model to understand the physico-chemical basis of halotolerance and protein-salt interactions in general.  (+info)

Taste buds and nerve fibers in the rat larynx: an ultrastructural and immunohistochemical study. (3/32)

We investigated the rat laryngeal taste buds and their innervation by electron microscopy and immunohistochemical methods. Taste buds were densely arranged in the surface facing the laryngeal cavity of the epiglottis, the aryepiglottic fold, and the cuneiform process of the arytenoid cartilages. The cells of the buds were classified into types I, II, III, and basal cells, the ultrastucture of which was almost the same as that previously reported in lingual taste buds. The type III cells that had synaptic contacts with nerve fibers were considered to be sensory cells. Immunohistochemical analysis revealed thick calbindin D28k-immunoreactive fibers and thin varicose fibers immunoreactive for calcitonin gene-related peptide or substance P in and around the taste bud. Serotonin-immunoreactive cells were also observed here. The results revealed the innervation pattern of laryngeal taste buds to be the same as that in lingual taste buds. Carbonic anhydrase (CA) is known to catalyze the hydration of CO2 and dehydration of H2CO3, and seems to be essential in CO2 reception. Immunoreactivity for CAI was detected in slender cells and that for CAIII was observed in barrel-like cells in the laryngeal taste buds. The pH-sensitive inward rectifier K+ (Kir) channel in the cell membrane may be involved in CO2 reception as well. CAII-reactive cells were also reactive to Kir4.1, PGP 9.5 and serotonin. Our results indicated that CAII and Kir4.1 are located in type III cells of the laryngeal taste buds, and supported the idea that the buds may be involved in the recognition of CO2.  (+info)

Measurement of erythrocyte carbonic anhydrase isozymes (CA-I and CA-II) in racehorses and riding horses. (4/32)

Equine carbonic anhydrase isozymes (CA-I and CA-II) were purified from erythrocytes by several column chromatography. Polyclonal anti-CA-I and anti-CA-II sera were produced in rabbits. Sensitive competitive enzyme-linked immunosorbent assays (ELISA) were established to determine the developmental changes in CA-I and CA-II levels in equine erythrocytes. Concentrations of CA-I and CA-II in erythrocytes from 150 clinically normal thoroughbreds (123 racehorses and 27 riding horses) were determined by ELISA. Mean (+/- SD) concentrations of CA-I and CA-II in racehorses were 1.70 +/- 0.48 and 0.94 +/- 0.13 mg/g hemoglobin (Hb), respectively. Mean concentrations of CA-I and CA-II in riding horses were 2.34 +/- 0.52 and 0.76 +/- 0.08 mg/g Hb, respectively. When the CA levels in racehorses and riding horses were compared, the CA-I level in riding horses was higher than that in racehorses (p=0.01). The CA-II level in racehorses was higher than that in riding horses (p=0.02). These data suggest that the levels of CA isozymes in erythrocytes of racehorses were influenced by chronic physical stress. The CA-I concentration in erythrocytes of 2-month-old horses was approximately 0.25 mg/g Hb. The CA-I level noticeably increased during the first year of life and approached normal adult levels by 2 years. The CA-II level decreased slightly with age, indicating different regulation of CA-I and CA-II expression during development.  (+info)

Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. (5/32)

BACKGROUND: Carbonic anhydrase (CA) isozymes may have an important role in cancer development. Some isozymes control pH homeostasis in tumors that appears to modulate the behaviour of cancer cells. CA XIII is the newest member of the CA gene family. It is a cytosolic isozyme which is expressed in a number of normal tissues. The present study was designed to investigate CA XIII expression in prospectively collected colorectal tumor samples. METHODS: Both neoplastic and normal tissue specimens were obtained from the same patients. The analyses were performed using CA XIII-specific antibodies and an immunohistochemical staining method. For comparison, the tissue sections were immunostained for other cytosolic isozymes, CA I and II. RESULTS: The results indicated that the expression of CA XIII is down-regulated in tumor cells compared to the normal tissue. The lowest signal was detected in carcinoma samples. This pattern of expression was quite parallel for CA I and II. CONCLUSION: The down-regulation of cytosolic CA I, II and XIII in colorectal cancer may result from reduced levels of a common transcription factor or loss of closely linked CA1, CA2 and CA13 alleles on chromosome 8. Their possible role as tumor suppressors should be further evaluated.  (+info)

Polyvinylpyrrolidone 40 assists the refolding of bovine carbonic anhydrase B by accelerating the refolding of the first molten globule intermediate. (6/32)

Protecting proteins from aggregation is one of the most important issues in both protein science and protein engineering. In this research, the mechanism of enhancing the refolding of guanidine hydrochloride-denatured carbonic anhydrase B by polyvinylpyrrolidone 40 (PVP40) was studied by both kinetic and equilibrium refolding experiments. The reactivation and refolding kinetics indicated that the rate constant of refolding the first refolding intermediate (I(1)) to the second one (I(2)) is promoted by the addition of PVP. Fluorescence quenching studies further indicated that PVP could bind to the aggregation-prone species I(1), resulting in the protection of the exposed hydrophobic surface, a minimization of the protein surface, and more importantly, an increase of the refolding rate of I(1). These properties were quite different from those of poly(ethylene glycol) (PEG), which has been shown to have a strong and stoichiometric binding to I(1) and does not interfere with the refolding pathway. Unlike PEG, the binding of PVP to I(1) does not block the aggregation pathway directly but decreases the energy barrier for I(1) to refold to I(2) and thus reduces the accumulation of I(1). These results suggested that PVP works by a quite different mechanism from those well established ones in chaperones and chemical promoters. PVP is more like a folding catalyst rather than a chemical chaperone. The distinct mechanism of enhancing protein aggregation by PVP is expected to facilitate the attempt to develop new chemical compounds as well as new strategies to protect proteins from aggregation.  (+info)

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity. (7/32)

The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.  (+info)

Immunohistolocalization of carbonic anhydrase isoenzymes (CA-I, -II and -III ) in canine epididymis. (8/32)

The immunolocalization of the efferent duct and the epididymis in canine was firstly examined using an the immunohistochemical method with the canine carbonic anhydrase (CA) -I, CA-II and CA-III antisera. The efferent duct was immunonegative for all present canine CA antisera. However, some slender shaped epithelial cells in the head and body segments of the epididymal duct were intensely reacted to the CA-II antiserum. These results suggested that the CA-II might be controlled in the luminal environment in the head and body segments of the canine epididymis by the proton and bicarbonate balance for the maintenance of the spermatozoal stability and movement.  (+info)

TY - JOUR. T1 - An immunocytochemical study of the carbonic anhydrase I isoenzyme in human oral Merkel cells. AU - Christie, K. N.. AU - Thomson, C.. AU - Hopwood, D.. AU - Harper, A. A.. AU - Ogden, G. R.. PY - 1996. Y1 - 1996. N2 - Merkel cells in human buccal mucosa and hard palate possess the carbonic anhydrase I isoenzyme (CAI). CAI colocalized immunocytochemically with a range of Merkel cell cytokeratins, namely CK 7, 8, 18, 19 and 20. No other cells in the oral epithelium were immunoreactive for the CAI antibody. The presence of the enzyme may be related to the function of sensory receptors that produce a sustained response to a maintained mechanical stimulus.. AB - Merkel cells in human buccal mucosa and hard palate possess the carbonic anhydrase I isoenzyme (CAI). CAI colocalized immunocytochemically with a range of Merkel cell cytokeratins, namely CK 7, 8, 18, 19 and 20. No other cells in the oral epithelium were immunoreactive for the CAI antibody. The presence of the enzyme may be ...
The structure of the gene encoding carbonic anhydrase I (CA I) was determined for the pigtail macaque Macaca nemestrina. When the deduced amino-acid sequence was compared with those of five other primates, four non-primate mammals and a turtle, seven residues were found to be unique and invariant to all of the CA I sequences. A scheme is presented for the probable evolutionary order of the six polymorphic nucleotide changes found in the coding regions of the CA I locus of pigtail macaques. ...
Sigma-Aldrich offers abstracts and full-text articles by [Vaida Morkūnaitė, Joana Gylytė, Asta Zubrienė, Lina Baranauskienė, Miglė Kišonaitė, Vilma Michailovienė, Vaida Juozapaitienė, Matthew J Todd, Daumantas Matulis].
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology. ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
2foy: Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
To further assess our results, we performed a literature review of the genes reported by at least seven studies in the cancer versus normal comparison to determine if any have been shown to have diagnostic and/or prognostic utility in colorectal cancer. The most consistently reported differentially expressed gene in our meta-analysis was carbonic anhydrase II (CA2), which was reported as down-regulated in 11 studies. Along with carbonic anhydrase I, CA2 has been shown to have prognostic significance where the expression of both enzymes was related to the metastatic aggressiveness of colorectal cancer (23). Similarly, the potential diagnostic utility of CA2 was shown in a study in which the average level of fecal CA2 in colorectal cancer patients was shown to be significantly greater than those in the control group (24). Immunohistochemistry has been done on colorectal tumor and healthy mucosa tissue to monitor the protein levels of four carbonic anhydrases, among them CA2 (25). That study showed ...
This product was first developed in Finland by Prof Heikki Karppanen, a well-published researcher of hypertension. The use of Pan salt is common in Finland, with a popular fast food chain advertising its use as a healthier alternative.. The formula employs two-prong approach to help better control blood pressure. The actual salt(sodium) content in only 57% that of normal salt. Studies have shown that by reducing sodium, better BP control can be achieved.. Secondly, the use of mineral salts such as potassium and magnesium, both of which have been shown to reduce blood pressure, potentiates its blood pressure lowering effect.. The best part is that the formula has been specially formulated to provide the same tast as that of normal salt. Some other formulas may taste bitter as both potassium and magnesium, naturally are bitter.. ...
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Healthy eating and exercise can help you lose weight and maintain weight, too. Being healthy requires a two-prong approach, and when you leave healthy food or exercise off of the schedule, youre simply not going to be as healthy as you think you are.. When trying to lose weight, you need to burn more calories than you consume.. Its pure mathematics, and if you eat more calories than you consume, you can be sure that youll gain weight.. Lets take a look at a few exercise and eating tips that can help you lose or maintain your weight while being the healthiest you possible ...
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Carbonic anhydrases are abundant in mammalian tissues, plants and bacteria. The several distinct classes of this enzyme (α, β, γ etc.) share little similarity in terms of structure and sequence, but they all perform the same function of catalyzing the hydration of carbon dioxide and the dehydration of bicarbonate [3]. Carbonic anhydrase B is one of the two major forms of carbonic anhydrase in human red blood cell (the other form is CA C). Like other members of the CA family, its main function is assisting the important chemical reaction that occurs in the blood. CO2 + H2O ,-----, HCO3- + H+. The above reaction is very slow in the absence of the enzyme. Hence, by assisting the inter-conversion between carbon dioxide and bicarbonate, Carbonic anhydrase B helps to maintain acid-base balance in blood, and transport carbon dioxide out of blood. Note that the carbonic acid (H2CO3) and hydrogen carbonate ions (HCO3-) is an important buffer system in the body. They equilibrate in the blood plasma to ...
Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related proteins. All seven isozymes have been cloned, sequenced, and mapped, and the intron-exon organization of five genes established. They differ in subcellular localizations, be …
The hydration rate of CO2 catalyzed by human red cell carbonic anhydrase B is 92 percent reduced by the normal concentrations of chloride and bicarbonate in red cells. This reflects a general sensitivity of this reaction to halides and other anions, up to 87 times greater than the effect on red cell carbonic anhydrase C. The catalytic hydration of CO2 is generally more (up to 24 times) sensitive to inhibition by anions and sulfonamides than the dehydration of HCO3-, probably reflecting different mechanisms. The sensitivity of enzyme B to anion inhibition also depends upon the substrate, being much greater for CO2 than for certain esters. On the basis of the very low catalytic activity of B for CO2 in the presence of physiological concentration of chloride, and the fact that carbonic anhydrase C is effective for CO2 hydration (in the presence of chloride) at a rate 340 times greater than that of CO2 output from tissues, it appears that the biological role of enzyme B is not that of a carbonic ...
Effect of Hyperglycemia on Erythrocyte Carbonic Anhydrase and Lactic Acid in Type II Diabetic Subjects. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
beta-Lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a beta-lactam ring in their molecular structures. Synthesis of beta-lactam analogs, which are containing dichloride atoms and N-methyl, N-aromatic rings, was achieved by Schiff bases and dichloroketene compounds. All the synthesized imines and beta-lactam analogs were tested against two physiologically relevant carbonic anhydrase isozymes (hCA I and II) and acetylcholinesterase (AChE). They demponstrated effective inhibitory profiles with K-i values in ranging of 3.22-11.18 nM against hCA I, 3.74-10.41 nM against hCA II, and 0.50-1.57 nM against AChE. On the other hand, acetazolamide and dorzolamide clinically used as CA inhibitors, showed K-i value of 170.34 and 129.26nM against hCA I, and 115.43 and 135.67 nM against hCA II, respectively. Also, tacrine used as standard AChE inhibitor showed Ki value of 5.70 nM against AChE ...
Lilly is a super sweet girl in need of a loving home as a broodmare, companion, or with some time off as a light riding horse. After 3 yrs of extensive training and attempts to rehab her, she still has a very sore back, which the vet feels could be kissing spines, but feels time off will help or a new job as a broodmare. Shes gorgeous, correctly put together, with a great temperament and would make a fantastic sporthorse broodmare! Email for more info, pics, and video. ...
When the family moved from Mission Viejo to Norco, Elle Martin got her first horse.. When Elle went to high school it became tough to attend horse shows, which run for about a week, and still maintain a 4.0 grade average.. I watched her sacrifice the horse shows for school work for three years, Nicol Martin said.. A friends mother recommended a charter school that offered an online program, Venture Online, which is part of Springs Charter Schools. Elle Martin now had the flexibility to practice riding and keep up her grades.. Elle Martin spends four to five hours a day practicing with horses and another two or three hours grooming them.. She has this natural ability that shines through, Nicol Martin said. Thats why shes great with different horses, it comes from the natural gift she has.. Elle Martins father, Michael, who also grew up riding, is amazed by her determination and competitiveness. Its awesome to see her guide a 1,000-pound animal over a course and over jumps.. Her ...
Have you ever ridden a horse? Do you have a brother? Well, I have a brother and I rode a horse. My brother isnt just an ordinary brother; hes my twin. He also has special needs. People treat him dif
Ideally, a closed lumbosacral transition in neutral position ensures the work of the lines and vice versa muscular active work of the lines ensures power transfer in the lumbosacral transition. This becomes particularly clear if you look at how much the lumbosacral transition region is spanned by muscles and fasciae. My picture here is that this is only possible if the action base for forward movements is at the back and that for upward movement is at the front. Only the vigorous forward movement out of the rear action base allows the front base to have a righting, muscular dominant, supporting motion. Successful interaction preserves the physiological movement phases of the limbs. The spine and ribcage remain in balance and, as an almost stabilizing pole, they enable balanced muscle action, in whatever form. For the transmission of motion these lead to an essential positive stiffening of the spine. ...
Middle Ages. In 1086 the estate at Compton was assessed at 5 hides, that at Dundon 5 hides, and that at Littleton at 3 hides, all 3 single holdings, although Littleton had been divided into 3 manors in 1066 and Compton had been shared between 2 monks. Details of demesne and tenants are not available for Compton, but both Dundon and Littleton had land for 4 teams. The demesne at Dundon measured 3 hides and ½ virgate and 4 serfs worked it with 2 teams; 5 villeins and 10 bordars worked the rest of the land with 3 teams. The demesne at Littleton also measured 3 hides (fn. 207) and 3 serfs worked it with 2 teams. Four villeins and 3 bordars with 1 team worked the rest. There were 20 a. of meadow at Compton and twice that much at both Dundon and Littleton. Stock comprised a riding horse, 2 beasts, 46 sheep, and 49 goats at Compton, 5 unbroken mares, 2 riding horses, and 9 pigs at Dundon, and 120 sheep at Littleton. (fn. 208) In 1283 the combined estates of Compton and Dundon had demesne measuring 330 ...
Where did the idea come from that you were going to disguise Elliots surroundings in this way? Sam Esmail: It came from a two-prong approach. We knew exactly what the fate of Elliot was at the end of the last season, and we started breaking this seasons storyline. Were always trying to stay as authentic to Elliot as possible, what hes going through. Knowing Elliot, from the very first episode, he definitely has interesting coping mechanisms. Even from the pilot, he has this ability to reprogram his life: E Corp was turned into Evil Corp. When we thought about him being in prison, what would be that coping mechanism, this came to mind. The other approach was his relationship to us - to his friend - and how we left him at the end of the first season. He basically didnt trust us anymore, he felt we were keeping things from him. So we wanted to develop that relationship as well. That was the one approach of, This is what Elliot would do in this situation, to cope with being in prison, and ...
A two-prong approach combining ibrutinib and rituximab (Rituxin®) to treat aggressive chronic lymphocytic leukemia (CLL) produced profound responses with minor side effects in a Phase 2 clinical trial at the University of ...
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Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. - Mechanism of Action & Protocol.
The 16th century was a very important period in the history of the Cossacks. At its commencement the inhabitants of the Pontic Steppe were a mix of disparate peoples living a frontier life, largely free of central control or the benefits of a settled existence, with little except their environment and the difficulties of existence in common. By its end these scattered elements had coalesced into a recognisable grouping or society which would be known as Cossack, and which increasingly cooperated and saw themselves as a distinct people with common interests and goals. As such they would achieve great fame, and be both friend and foe to those states that bordered their territory and increasingly took an interest in them.. Their lifestyle meant they were no strangers to riding horses, and while many did their fighting on foot, particularly when in the pay of outsiders, there were already those that were skilled in mounted warfare, a feature many today associate with all Cossacks. This is the first ...
The Half Saddlebred is an American crossbreed with excellent characteristics. Often used as a riding horse, it is one of the most sought-after equine breeds in the world.
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View Notes - Organic Lab Reactions 174 from CHM 2210 at University of Florida. STANNIC CHLORIDE ON THE FREE ACID 169 Other Methods The extent of consideration given to the methods of cyclization
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Am zis ca-i monitorul de vina. Acum 2 saptamani..n-a mai vrut de niciun fel!Inchis-deschis..scos din prinza..nimic,nada,niente...chinuitor ptr ca aveam si de lucru.Imprumut un alt monitor si zic..gata il arunc pe cel vechi pe geam.Iete ca facea la fel!Bun...ce altceva?Placa video! Scimba placa video, la fel probleme. Schimba slotul..tot la fel.Cand inchideam monitorul in unele dati becul de power nu se stingea ci ramanea oleaca mai deschis.Un prieten mi-a zis ca poate e de la sursa.Am schimbat si sursa....La fel face..doar ca acum e mai docil si face doar o singura data ...
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BioExpress accepts no responsibility and shall not be held liable for loss, damage, expense, consequential, or accidental damage. This includes the damage to property, person, or premises resulting from these products. BioExpress MAKES NO WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING, WITHOUT LIMITATION, THE WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURCHASE. BioExpress expressly disclaims all other warranties, whether express, implied or statutory, including the warranty of MERCHANTABILITY AND FITNESS FOR USE. In no event will BioExpress be liable for consequential damages arising from the use of products described in this catalog.. ...
A recording liquid comprising an aqueous medium and at least one dye selected from dyes, the free acid forms of which are represented by formula (I): ##STR1## All the symbols in formula (I) are defined in the description.
Dorzolamide is a sulfonamide and a highly specific carbonic anhydrase II (CA-II) inhibitor, which is the main CA isoenzyme involved in aqueous humor secretion. Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Dorzolamide also accumulates in red blood cells as a result of CA-II binding, as CA-II is found predominantly in erythrocytes. However, sufficient CA-II activity remains so that adverse effects due to systemic CA inhibition are not observed ...
The new antitumor sulfamate EMD 486019 was investigated for its interaction with twelve catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isozymes, hCA I - XIV. Similarly to 667-Coumate, a structurally related compound in phase II clinical trials as steroid sulfatase/CA inhibitor with potent antitumor properties, EMD 486019 acts as a strong inhibitor of isozymes CA II, VB, VII, IX, XII, and XIV (K(I)s in the range of 13-19nM) being less effective against other isozymes (K(I)s in the range of 66-3600nM against hCA I, IV, VA, VI, and mCA XIII, respectively). The complete inhibition profile of 667-Coumate against these mammalian CAs is also reported here for the first time. Comparing the X-ray crystal structures of the two adducts of CA II with EMD 486019 and 667-Coumate, distinct orientations of the bound sulfamates within the enzyme cavity were observed, which account for their distinct inhibition profiles. CA II/IX potent inhibitors belonging to the sulfamate class are thus ...
I reckon that riding a horse in a drunken state was a common occurrence 150 years ago. I also reckon that it happens more often than we hear about it right now. Here is a tale of a modern-day riding under the influence (RUI) violation.. The cowboy, Patrick Neal Schumacher, appears to be a real horses patoot! The 45-year-old from Colorado Springs, Colorado was arrested by University of Colorado police after being spotted riding his horse down the middle of the street and swerving onto sidewalks in downtown Boulder, Colorado on September 9th.. ...
What is Live Action News?. Live Action News is pro-life news and commentary from a pro-life perspective. Learn More. Corrections or Questions. For corrections, or questions, please contact the editor at [email protected]. We welcome guest posts. Submit articles via email: [email protected] ...
As demonstrated in the accompanying figures, use a two-prong retractor and the middle finger of the nondominant hand to expose the lower lateral cartilage
The report generally describes linoleoyl coenzyme a, free acid, examines its uses, production methods, patents. Linoleoyl Coenzyme A, Free Acid market
1. I love to read and write, but to me theyre one in the same. 2. Ive been riding horses for 11 years. 3. I love medieval things and I am the proud owner of 2 small swords and 1 dagger. 4. I absolutely LOVE dragons! & 5. I love when it rains.
Is this the same Joseph Lister who discovered listers oil in the world of The Stormlight Archive? Probably not, although its possible that Lister represents the Platonic ideal of inventing sanitation in Sandersons mind. Either way, his fantasy innovations have brought medical science to the levels of the dawn of the modern era, while most of the rest of Roshars technology is still medieval at best. Surgeons are extremely highly trained, maintain clean operating rooms, use antiseptic, have primitive anaesthetic, and seem to save far more people than they lose, even when they have to amputate limbs. None of this was possible in real life until a time when we had guns, trains, steamboats, and light blubs. People in Alethkar, the main nation in The Way of Kings, are still riding horses, traveling long distances by carriage, and swinging swords at each other, albeit massive ancient swords called Shardblades that cut through stone like paper and burn the souls right out of a persons body. Im not ...
Prahran. Nancy was born in 1930 in the City of Prahran, not far from where her maternal grandparents lived in Caulfield. Her mother, Lizzie Bidstrup, was 42 years old and her father Ernest 43. Nancy was the third child and only daughter.. Annadale. Nancy grew up on the farm at Annadale, undertaking her schooling at the Sugarloaf Creek School. Like her brothers, George and Alan, she participated in farm life, including riding horses. Her senior years of schooling were at Firbank Girls Grammar School in Brighton.. Brother George:. Towards the end of WW2 she tragically lost her oldest brother George, a flight officer with the RAAF, to a plane crash in the Barrington Tops.. Home Life and Travels:. After finishing schooling Nancy returned home, assisting her mother. She would travel with her father and mother, including visits to her Uncle Walter and cousins in Queensland. It would have been quite an undertaking considering the likely state of the roads in the late 40s post war and the 1950s. ...
April 27, 2012. Washington, April 27, 2012 -- Health workers are walking, pedaling bicycles, driving cars, rowing boats and riding horses to reach remote areas, urban fringes and displaced communities, where they are giving vaccines against diseases like measles and polio as part of the first World Immunization Week taking place in 180 countries this week. ...
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BioAssay record AID 644085 submitted by ChEMBL: Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis.
FUNCTIONS OF CARBONIC ANHYDRASES. The presence of carbonic anhydrases in all living organisms probably originates because the components of the catalyzed reaction are involved in almost all metabolic processes. We suppose that the main reason for the abundance of CAs in nature is the ubiquitous involvement of bicarbonate buffers in aqueous media and then in the cytoplasm at every stage of evolution; these enzymes acceleration achieving appropriate pH, which is important for homeostasis of every living cell. The role of carbonic anhydrases in accelerating the conversion of inorganic forms of carbon was probably not their initial main function, but now it is established that these enzymes are critical regulators of the exchange of these forms in many metabolic processes.. Functions of Carbonic Anhydrases in Animals. Although the main purpose of this review is to consider the available experimental data and ideas concerning the role of CAs in higher plants, we should present, at least briefly, ...
Abstract: Resistively heated diamond-anvil cells have been used together with synchrotron x-ray diffraction to investigate the phase diagram of calcium up to 50 GPa and 800 K. The phase boundaries between the Ca-I (fcc), Ca-II (bcc), and Ca-III (simple cubic, sc) phases have been determined at these pressure-temperature conditions, and the ambient temperature equation of state has been generated. The equation of state parameters at ambient temperature have been determined from the experimental compression curve of the observed phases by using third-order Birch-Murnaghan and Vinet equations. A thermal equation of state was also determined for Ca-I and Ca-II by combining the room-temperature Birch-Murnaghan equation of state with a Berman-type thermal expansion model ...
We report the cloning, purification and characterization of the full domain of carbonic anhydrase (CA, EC 4.2.1.1) from Plasmodium falciparum, which incorporates 358 amino acid residues (from 181 to 538, in the sequence of this 600 amino acid long protein), called PfCAdom. The enzyme, which belongs to the η-CA class showed the following kinetic parameters: kcat of 3.8×10(5)s(-1) and kcat/Km of 7.2×10(7)M(-1)×s(-1), being 13.3 times more effective as a catalyst compared to the truncated form PfCA. PfCAdom is more effective than the human (h) isoform hCA I, being around 50% less effective compared to hCA II, one of the most catalytically efficient enzymes known so far. Intriguingly, the sulfonamides CA inhibitors generally showed much weaker inhibitory activity against PfCAdom compared to PfCA, prompting us to hypothesize that the 69 amino acid residues insertion present in the active site of this η-CA is crucial for the active site architecture. The best sulfonamide inhibitors for PfCAdom ...
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Continuation of an article by ©2005 By Deb Bennett, Ph.D.:. What Does it Mean to Start a Young Horse?. Let us now turn to the second discussion, which is what I mean by starting and the whole history of that. Many people today - at least in our privileged country - do not realize how hard you can actually work a mature horse - which is very, very hard. But before you can do that without significantly damaging the animal, you have to wait for him to mature, which means - waiting until he is four to six years old before asking him to carry you on his back.. What bad will happen if you put him to work as a riding horse before that? Two important things - and probably not what youre thinking of. What is very unlikely to happen is that youll damage the growth plates in his legs. At the worst, there may be some crushing of the cartilages, but the number of cases of deformed limbs due to early use is tiny. The cutting-horse futurity people, who are big into riding horses as young as a year and a ...
View and buy high quality Janelia Fluor 646, free acid from Tocris Bioscience. Red dye (Reactive group: free acid). Applications: super resolution microscopy e.g. dSTORM & STED, confocal, flow and live cell imaging.
Stunning true black kind and loving girl. She immediately wanted me to give her a scratch when I met her. I love doing this, I get to meet so many wonderful horses.She needs time before being a riding horse. She has a fractured sesamoid, but is nearly sound. See her pictures at www.LeightonFarm.com or call me for more information! ...
A blog about farming and ranching in Southwest Virginia. Training horses, riding horses, showing horses, raising cattle, beef cattle and goats.
My greatest accomplishment is being a MOM! After that nothing is really important if you take that away.... However, in the quiet moments, before the roosters crow, and the sun begins to peek above the trees, I love to sit and scrapbook and work on my family heritage. Since discovering Scrapbooking two years ago, I have also rediscovered my camera.... looking through the lens at the world gives new meaning and light to everything I see. Everything is a moment to capture and create. When spending time with family and friends, I love to spend time outdoors, riding horses, playing in the mud, hunting and fishing and doing whatever our hearts desire...the smallest of moments are my greates joys. Life is not measured by the number of breaths we take, but instead by the number of moments that take our breath away ...
My greatest accomplishment is being a MOM! After that nothing is really important if you take that away.... However, in the quiet moments, before the roosters crow, and the sun begins to peek above the trees, I love to sit and scrapbook and work on my family heritage. Since discovering Scrapbooking two years ago, I have also rediscovered my camera.... looking through the lens at the world gives new meaning and light to everything I see. Everything is a moment to capture and create. When spending time with family and friends, I love to spend time outdoors, riding horses, playing in the mud, hunting and fishing and doing whatever our hearts desire...the smallest of moments are my greates joys. Life is not measured by the number of breaths we take, but instead by the number of moments that take our breath away ...
Im a recent graduate from the Microbial Biology program at University of California, Berkeley. I originally started in the lab as an undergraduate researcher, summer 2015. I work on a variety of projects in the Brem lab, including understanding the genetics of interspecies trait differences in saccharomyces and yeast replicative lifespan studies. Outside of lab, you can usually find me hiking or riding horses or trying new craft beers. ...
Howdy,, hows the world treating you? Going good here,,no big complaints, we have been doing fall clean up,,the garden is stripped and all we have are a few tomatoes and peppers,, oh yes butternut squash,, we ended up with over 75 of them , trying to figure out what to do with all of them ! Grandkids are here, riding horses, and doing the youth deer hunting with grandpa,,so far the deer is winning,, Weather is finally cooling down ,, oh on a cuteness note,, I tried to get a picture
Its time to add another riding horse to the farm anyhow, so Ive been looking for a gelding that does well with both mares and colts. The right gelding hasnt come along... BUT... Ive found a mare that had a double oophorectomy (aka ovariectomy or spaying) completed. Im wondering if anyone has any experience with spayed mares interacting with uncut colts ...
I like writing, drawing, riding horses, playing sports,and just getting outside. My first books were 20 post-it notes stuck together when I was about six years old. i survive off my friends, writing and music. I also read a lot.
Reaction product of acid red 143 (free acid) or the respective sodium salt (e.g Lansyn red F-5B) (UVCB) with Tetrabutylammonium bromide (CAS nr.: 1643-19-2) resulting in a mixture of AR143-(TBN)2 (Main component), AR143-(TBN), AR143-(TBN)3, AR143-(TBN) without alkyl tail, AR143-(TBN)2 without alkyl tail.Chemical name main component AR143-(TBN)2:di-(tetra-n-butylammonium) salt of 1-benzoyl-4-[4-(1,1-dimethylpropyl)-phenoxy]-6-phenylamino-2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinolin, disulfonic acid ...
Available forms. HMB is sold worldwide as an over-the-counter dietary supplement in the free acid form, β-hydroxy β-methylbutyric acid (HMB-FA), and as a monohydrated calcium salt of the conjugate base, calcium β-hydroxy β-methylbutyrate monohydrate (HMB-Ca, CaHMB). It is sold at a cost of about US$30-50 per month when taken in doses of 3 grams per day ...
It is important to see the needs of the racehorse as being different from horses kept for any other sporting purpose. Its management, feeding, training and stabling are all critical and unique. Peter Gray (European Trainer - issue 21 - Spring 2008)
Information on how you can help us care for, rehabilitate and retrain retired racehorses or adopt a horse of your own. 817-689-1214
At CIL, reference standards with concentration based on gravimetry are carefully weighed, dissolved and diluted by weight, then packaged. The Concentration Based on Gravimetry is given in mass of compound per volume of solvent using the density of the solvent and is adjusted for the purity of the neat material. If the compound dissolved is a salt, the concentration by gravimetry is based on the mass of the salt form.
Grade: Biotech Appearance Fine, white homogeneous powder Moisture content ≤10% Gel Strength 1.5% ≥1,120 g/cm2 Gelling Point 34.5 - 37.5°C Electroendosmosis-Mr 0.09-0.13 Sulfate ≤0.15% DNase , RNase and protease None detected ...
A study designed to investigate the behaviour of specific horse immune receptors, and how their activity may be changed with drugs. ...
Laura Corbin, Sarah Blott, June Swinburne, Charlene Sibbons, Laura Fox-Clipsham, Maud Helwegen Tim Parkin, Richard Newton, Lawrence Bramlage, Wayne McIlwraith, Stephen Bishop, John Woolliams, Mark Vaudin ...
A site devoted to treating and racing the racehorse with herbal and other holistic remedies with this page devoted to the health of the racehorse.
Catalyzed by carbonic anhydrase, carbon dioxide (CO2) reacts with water (H2O) to form carbonic acid (H2CO3), which in turn ... Meldrum, N. U.; Roughton, F. J. W. (1933-12-05). "Carbonic anhydrase. Its preparation and properties". The Journal of ... causing carbonic anhydrase to form CO2 until all excess acid is removed. Bicarbonate concentration is also further regulated by ... are facilitated by carbonic anhydrase in both the blood and duodenum. While in the blood, bicarbonate ion serves to neutralize ...
"Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British Journal of ... Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class. ...
Casini, Angela (2004). "Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH". ... Casini, Angela (2004). "Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological ... "Carbonic anhydrase inhibitors". Medicinal Research Reviews. 23 (2): 146-189. doi:10.1002/med.10025. PMID 12500287. S2CID ...
... cerebral carbonic anhydrase activation has cognition-enhancing effects; but, based upon the clinical use of carbonic anhydrase ... CARBONIC ANHYDRASE INHIBITORS (CAIs). The design and development of CAIs represent the most prolific area within the CA ... Bozdag M, Altamimi AA, Vullo D, Supuran CT, Carta F (2019). "State of the Art on Carbonic Anhydrase Modulators for Biomedical ... Amphetamine also activates seven human carbonic anhydrase enzymes, several of which are expressed in the human brain. ...
It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also ... Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport ... Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water ... Dimazole Dithiazanine iodide Gordon DM (July 1958). "Ethoxzolamide; a new carbonic anhydrase inhibitor". American Journal of ...
... forms of carbonic anhydrase. The action on carbonic anhydrase isoenzymes may contribute to the drug's side-effects, including ... As topiramate inhibits carbonic anhydrase, use with other inhibitors of carbonic anhydrase (e.g. acetazolamide) increases the ... Topiramate, sold under the brand name Topamax among others, is a carbonic anhydrase inhibitor medication used to treat epilepsy ... the inhibition of carbonic anhydrase may be strong enough to cause metabolic acidosis of clinical importance. The U.S. Food and ...
Carbonic anhydrase-related protein 11 is an enzyme that in humans is encoded by the CA11 gene. Carbonic anhydrases (CAs) are a ... "Entrez Gene: CA11 carbonic anhydrase XI". CS1 maint: discouraged parameter (link) Liao W, Xiao Q, Tchikov V, Fujita K, Yang W, ... Bellingham J, Gregory-Evans K, Gregory-Evans CY (1998). "Sequence and tissue expression of a novel human carbonic anhydrase- ... Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S (2001). "cDNA sequence of human carbonic anhydrase-related ...
Some of chlortalidone's diuretic effect is also due to this inhibition of carbonic anhydrase in the proximal tubule. Chronic ... Johnston MM, Li H, Mufson D (December 1977). "Chlorthalidone analysis using carbonic anhydrase inhibition". J Pharm Sci. 66 (12 ... it also strongly inhibits multiple isoforms of carbonic anhydrase. ...
3 A reaction similar to this is almost instantaneous with carbonic anhydrase. The structure of the active site in carbonic ... Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi:10.1016/ ... In aqueous solution, carbon dioxide forms carbonic acid CO2 + H2O ⇌ H2CO3 This reaction is very slow in the absence of a ... carbonic anhydride) proceeds rapidly. The catalytic cycle produces the bicarbonate ion and the hydrogen ion as the equilibrium ...
Carbonic anhydrase is one of the fastest enzymes, and its rate is typically limited by the diffusion rate of its substrates. ... Lindskog S (1997). "Structure and mechanism of carbonic anhydrase". Pharmacology & Therapeutics. 74 (1): 1-20. doi:10.1016/ ...
"Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase as indicator of luteoid potency: ...
It is a weak carbonic anhydrase inhibitor. Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic ... anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. doi: ...
Sato S, Zhu XL, Sly WS (1990). "Carbonic anhydrase isozymes IV and II in urinary membranes from carbonic anhydrase II-deficient ... "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annu. Rev. Biochem. 64 (1): 375-401. doi:10.1146/annurev.bi. ... Roth DE, Venta PJ, Tashian RE, Sly WS (1992). "Molecular basis of human carbonic anhydrase II deficiency". Proc. Natl. Acad. ... Sly also identified the first inherited deficiency of a human carbonic anhydrase, CA II, and defined the biochemical and ...
"Carbonic anhydrase in the female reproductive tract. II. Endometrial carbonic anhydrase as indicator of luteoid potency: ... to possess similar potency to progesterone and hydroxyprogesterone caproate in the rabbit endometrial carbonic anhydrase test, ...
Cadmium Carbonic anhydrase Diatoms Cullen, Jay T.; Maldonado, Maria T. (2013). "Biogeochemistry of Cadmium and Its Release to ...
doi:10.1016/S0031-9422(00)83125-8. Satomi H, Umemura K, Ueno A, Hatano T, Okuda T, Noro T (August 1993). "Carbonic anhydrase ... It is a weak carbonic anhydrase inhibitor. Ellagic acid and corilagin inhibit TGF-β1-dependent EMT and has been shown to ...
Carbon Dioxide Removal from e.g. Blood using Membrane and Immobilized Carbonic Anhydrase; Artificial Lung for Example, US ...
It is a highly active carbonic anhydrase inhibitor. The molecule contains a gallagic acid component linked to a glucose. Zhang ... Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of ...
It is a highly active carbonic anhydrase inhibitor. www.chemicalbook.com Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ...
... is a carbonic anhydrase inhibitor. Carbonic anhydrase inhibitors: binding of indanesulfonamides to the ...
It is a highly active carbonic anhydrase inhibitor. In some plants including oak and chestnut, the ellagitannins are formed ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ...
Likewise, in some cyanobacterial strains the beta-carboxysomes contain a beta-carbonic anhydrase that is not found in the ccm ... The signature proteins of the beta-carboxysome are Form IB RuBisCO and a gamma carbonic anhydrase homolog. Beta-carboxysomes ... CsoSCA is a shell-associated beta-carbonic anhydrase. Studies in Halothiobacillus neapolitanus have shown that empty shells of ... Cannon, Gordon C.; Heinhorst, Sabine; Kerfeld, Cheryl A. (2010). "Carboxysomal carbonic anhydrases: Structure and role in ...
bicarbonate derived from carbonic anhydrase (CA)-dependent hydration. CO2 metabolism Enters through membrane-transporting ... sAC inside mitochondria is activated by metabolically generated CO2 through carbonic anhydrase. Astrocytes express several sAC ...
It is a highly active carbonic anhydrase inhibitor. It is an isomer of terflavin B. It can be synthesized. Satomi, H.; Umemura ... "Carbonic anhydrase inhibitors from the pericarps of Punica granatum L". Biological & Pharmaceutical Bulletin. 16 (8): 787-790. ...
Davenport, Horace W. (1984-06-01). "The Early Days of Research on Carbonic Anhydrase" (PDF). Annals of the New York Academy of ... Lutwak-Mann was known for discovering that the hormone progesterone acts on the placenta to control carbonic anhydrase ... Davenport, Horace W. (1980-04-01). "Carbonic Anhydrase, or the Strange Case of the Disappearing Scientist". The Physiologist. ...
Carbonic anhydrase inhibitors also decrease fluid production. They are available as eye drops (Trusopt and Azopt) and pills ( ...
2000). "Crystal structure of S-glutathiolated carbonic anhydrase III". FEBS Lett. 482 (3): 237-41. doi:10.1016/S0014-5793(00) ...
It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary ... Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary ...
Satomi, H.; Umemura, K.; Ueno, A.; Hatano, T.; Okuda, T.; Noro, T. (1993). "Carbonic anhydrase inhibitors from the pericarps of ... In laboratory research, punicalagins had carbonic anhydrase inhibitor activity. Marzouk, M. S. A.; El-Toumy, S. A. A.; Moharram ...
... for example due to a deficiency of the carbonic anhydrase enzyme encoded by the CA2 gene. Carbonic anhydrase is required by ...
carbonic anhydrase (chloride shift). *oxyhemoglobin. *respiratory quotient. *arterial blood gas. *diffusion capacity (DLCO) ...
4.2 Carbonic anhydrase. Miscellaneous. *Steroidogenesis inhibitor. Retrieved from "https://en.wikipedia.org/w/index.php?title= ...
Pervasive and required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, and carbonic anhydrase ...
Carbonic anhydrase inhibitorsEdit. Carbonic anhydrase inhibitors inhibit the enzyme carbonic anhydrase which is found in the ... Carbonic anhydrase inhibitors acetazolamide,[17] dorzolamide Inhibits H+ secretion, resultant promotion of Na+ and K+ excretion ...
"Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase ...
Murakami, H. and Sly, W.S. (1987). "Purification and characterization of human salivary carbonic anhydrase". J. Biol. Chem. 262 ... Keilin, D. and Mann, T. (1939). "Carbonic anhydrase". Nature 144: 442-443. ...
Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/hyperosmotics, cholinergics, miotics, ...
Carbonic anhydrase. *Fumarase. *Aconitase. *Enolase *Alpha. *Enolase 2. *Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase ...
carbonic anhydrase(英语:carbonic anhydrase) (chloride shift(英语:chloride shift)) ...
... which is rapidly converted to hydrogen and bicarbonate through the action of carbonic anhydrase.[58] When the ECF pH falls ( ... The bicarbonate buffer system regulates the ratio of carbonic acid to bicarbonate to be equal to 1:20, at which ratio the blood ... This is tightly regulated to ensure that there is no excessive build-up of carbonic acid or bicarbonate. The overall effect is ... The hydrogen ions combine with the excess bicarbonate ions in the plasma, once again forming an excess of carbonic acid which ...
... secretes carbonic anhydrase (gustin), which is thought to play a role in the development of taste buds.[9] ...
Through the enzyme carbonic anhydrase, carbon dioxide reacts with water to give carbonic acid, which decomposes into ...
Band 3 - also assembles various glycolytic enzymes, the presumptive CO2 transporter, and carbonic anhydrase into a ...
... a carbonic anhydrase inhibitor Lithium was previously used for treatment of PPD as a direct competitive ADH agonist, but is now ...
Carbonic anhydrase. DNA polymerase A simple [Fe2S2] cluster containing two iron atoms and two sulfur atoms, coordinated by four ...
The reaction catalyzed by carbonic anhydrase is: HCO3- + H+ ↽. −. ⇀. {\displaystyle {\ce {,=,,}}}. CO2 + H2O. Carbonic acid has ... Cadmium-containing carbonic anhydraseEdit. Marine diatoms have been found to express a new form of ζ carbonic anhydrase. T. ... Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Differences from other carbonic anhydrasesEdit. Unlike most other carbonic anhydrases, the active site metal ion is not bound ...
An enzyme, carbonic anhydrase, located within the carboxysome releases CO2 from the dissolved hydrocarbonate ions (HCO−. 3). ... 3 ions are made from CO2 outside the cell by another carbonic anhydrase and are actively pumped into the cell by a membrane ... and within the cytosol they turn back into CO2 very slowly without the help of carbonic anhydrase. This causes the HCO−. 3 ions ... for the biological process of synthesis of complex carbon compounds out of carbonic acid, in the presence of chlorophyll, under ...
... which acts by inhibiting the enzyme carbonic anhydrase, and it reduces CSF production by six to 57 percent. It can cause the ...
1995). «The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell ...
"The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition ...
Zinc required for several enzymes such as carboxypeptidase, liver alcohol dehydrogenase, and carbonic anhydrase ...
Carbonic anhydrase inhibitors/. (sulfonamides). *Acetazolamide. *Brinzolamide (+timolol). *Diclofenamide. *Dorzolamide (+ ...
carbonic anhydrase (chloride shift). *oxyhemoglobin. *respiratory quotient. *arterial blood gas. *diffusion capacity (DLCO) ... Only CO2 levels affect this as it can diffuse across, reacting with H2O to form carbonic acid and thus decrease pH. Central ...
Fluid production can be decreased by beta blockers, alpha2-agonists, and carbonic anhydrase inhibitors.[7] ...
"Entrez Gene: CA9 carbonic anhydrase IX".. *^ Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E ... Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.[5][6][7] ... Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas". Digestive and Liver Disease. 33 (1): 68-74. ... Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. ...
carbonic anhydrase (chloride shift). *oxyhemoglobin. *respiratory quotient. *arterial blood gas. *diffusion capacity (DLCO) ...
... or direct vasodilator actions either through inhibition of carbonic anhydrase or by desensitizing the vascular smooth muscle ...
Raymond H & Swenson E (2000). "The distribution and physiological significance of carbonic anhydrase in vertebrate gas exchange ...
The reaction is therefore catalyzed by carbonic anhydrase, an enzyme inside the red blood cells.[21] The reaction can go in ... Henry RP, Swenson ER (June 2000). "The distribution and physiological significance of carbonic anhydrase in vertebrate gas ...
Carbohydrate deficient glycoprotein syndrome Carbon baby syndrome Carbonic anhydrase II deficiency Carcinoid syndrome Carcinoma ...
"Entrez Gene: CA9 carbonic anhydrase IX".. *^ Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E ... Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene.[5][6][7] ... Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas". Digestive and Liver Disease. 33 (1): 68-74. ... Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. ...
Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Carbonic anhydrase inhibitor Badger MR, Price GD (1994). "The role of carbonic anhydrase in photosynthesis". Annu. Rev. Plant ... Carbonic anhydrase could in principle prove relevant to carbon capture. Some carbonic anhydrases can withstand temperatures up ... Class one being alpha carbonic anhydrase which is found in mammals, class two being beta carbonic anhydrase which is found in ...
Carbonic anhydrase 4 is an enzyme that in humans is encoded by the CA4 gene. Carbonic anhydrases (CAs) are a large family of ... "Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from ... Other forms of carbonic anhydrase enzyme are not present in the plasma, restricting the equilibrium reaction of CO2+H2O = H2CO3 ... "Entrez Gene: CA4 carbonic anhydrase IV". Sterling D, Alvarez BV, Casey JR (Jul 2002). "The extracellular component of a ...
Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain ... Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401. Review. Citation on PubMed ... Hyperammonemia due to carbonic anhydrase VA deficiency. *Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency ... medlineplus.gov/genetics/condition/carbonic-anhydrase-va-deficiency/ Carbonic anhydrase VA deficiency. ...
... people with carbonic anhydrase VA deficiency have excess ammonia in the blood (hyperammonemia), problems with acid-base balance ... Carbonic anhydrase VA deficiency is an inherited disorder characterized by episodes during which the balance of certain ... Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem. 1995;64:375-401. Review. Citation on PubMed ... Hyperammonemia due to carbonic anhydrase VA deficiency. *Hyperammonemic encephalopathy due to carbonic anhydrase VA deficiency ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Carbonic anhydrase superfamily (IPR036874). Short name: Carbonic_anhydrase_sf Overlapping entries *Carbonic anhydrase ( ... Carbonic anhydrases (EC:4.2.1.1) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In ... Carbonic anhydrase in Escherichia coli. A product of the cyn operon.. J. Biol. Chem. 267 3731-4 1992 ... A gene homologous to chloroplast carbonic anhydrase (icfA) is essential to photosynthetic carbon dioxide fixation by ...
Alpha carbonic anhydrase domain (IPR001148). Short name: CA_dom Overlapping homologous superfamilies *Alpha carbonic anhydrase ... Carbonic anhydrases--an overview.. Curr. Pharm. Des. 14 603-14 2008. Smith KS, Ferry JG. Prokaryotic carbonic anhydrases.. FEMS ... A carbonic anhydrase-like domain with striking homology to that of the alpha class carbonic anhydrases is also found in ... Carbonic anhydrases (CA: EC:4.2.1.1) are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to ...
A carbonic anhydrase from the archaeon Methanosarcina thermophila. B E Alber and J G Ferry ... Carbonic anhydrase (CA) from acetate-grown Methanosarcina thermophila was purified , 10,000-fold (22% recovery) to apparent ...
Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in ... Carbonic anhydrase inhibition in ophthalmology: Carbonic anhydrases in cornea, lens, retina and lacrimal gland ... The Carbonic Anhydrases. New Horizons. Editors: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (Eds.) ... Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in ...
Carbonic anhydrases (CAs, EC 4.2.1.1) are zinc enzymes acting as efficient catalysts for the reversible hydration of carbon ... Carbonic anhydrases as targets for medicinal chemistry.. Supuran CT1, Scozzafava A. ...
Structural analysis of inhibitor binding to human carbonic anhydrase II.. Boriack-Sjodin, P.A., Zeitlin, S., Chen, H.H., ... X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural ... X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural ... the newest carbonic anhydrase inhibitor approved for the treatment of glaucoma.. Organizational Affiliation: Department of ...
The reaction catalyzed by carbonic anhydrase is: HCO3- + H+ ↽. −. ⇀. {\displaystyle {\ce {,=,,}}}. CO2 + H2O. Carbonic acid has ... Cadmium-containing carbonic anhydraseEdit. Marine diatoms have been found to express a new form of ζ carbonic anhydrase. T. ... Several forms of carbonic anhydrase occur in nature. In the best-studied α-carbonic anhydrase form present in animals, the zinc ... Differences from other carbonic anhydrasesEdit. Unlike most other carbonic anhydrases, the active site metal ion is not bound ...
Carbonic anhydrase 2. A. 260. Homo sapiens. Mutation(s): 0 Gene Names: CA2. EC: 4.2.1.1. ... which have been investigated for the inhibition of five physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1) ... which have been investigated for the inhibition of five physiologically relevant human carbonic a ... ...
Compare carbonic anhydrase inhibitor anticonvulsants. View important safety information, ratings, user reviews, popularity and ... Carbonic anhydrase inhibitor anticonvulsants. What are Carbonic anhydrase inhibitor anticonvulsants. Carbonic anhydrase ... inhibitor anticonvulsants inhibit the enzyme carbonic anhydrase. Generally carbonic anhydrase inhibitors are used to treat ... Home › Drug Classes › Central Nervous System Agents › Anticonvulsants › Carbonic Anhydrase Inhibitor Anticonvulsants ...
Carbonic anhydrase inhibitors decrease aqueous production by inhibiting ion transport associated with the secretion of aqueous ... Adequate inhibition of carbonic anhydrase with systemic administration has been shown to cause a decrease in aqueous humor ... Carbonic anhydrase inhibitors decrease aqueous production by inhibiting ion transport associated with the secretion of aqueous ...
Helping you find trustworthy answers on Intraocular Carbonic Anhydrase Inhibitor , Latest evidence made easy ... Find all the evidence you need on Intraocular Carbonic Anhydrase Inhibitor via the Trip Database. ... steroids, carbonic anhydrase inhibitors, or warfarin/heparin within 1 month prior to the Screening visit or anticipated use at ... If intraocular pressure is still elevated, a topical carbonic anhydrase inhibitor should be added. In patients with sickle cell ...
Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including ... Expression of carbonic anhydrase IV in carbonic anhydrase II-deficient mice. Am J Physiol 42:F234-F245Google Scholar ... Carbonic anhydrase II Osteopetrosis Renal tubular acidosis Osteoclast Osteoblast This is a preview of subscription content, log ... Whyte MP (1993) Carbonic anhydrase-II deficiency. Clin Orthop Relat Res 294:52-63PubMedGoogle Scholar ...
Romanova AK, Rusinova NG, Kornitskaya VM (1972) Participation of carbonic anhydrase in chemosynthetic assimilation of carbonic ... Graham D (1982) Carbonic anhydrases (carbonate dehydratases) from plants. In: Mitsui A, Black CC (eds) CRC handbook of biosolar ... Hogetsu D, Miyachi S (1979) Role of carbonic anhydrase in photosynthetic CO2 fixation in Chlorella. Pl Cell Physiol 220:747-756 ... Graham D, Reed M (1971) Carbonic anhydrase and the regulation of photosynthesis. Nature (New Biol) 231:81-83Google Scholar ...
ESCUDERO-ALMANZA, Dalila Jacqueline et al. Carbonic Anhydrase and Zinc in Plant Physiology. Chilean J. Agric. Res. [online]. ... Carbonic anhydrase (CA) (EC: 2.4.1.1) catalyzes the rapid conversion of carbon dioxide plus water into a proton and the ... Carbonic anhydrase is a metalloenzyme that requires Zn as a cofactor and is involved in diverse biological processes including ...
... have been demonstrated to physically and/or functionally interact with isoforms of carbonic anhydrase (CA) to form a transport ... monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase ... Extracellular loop 4 of the human AE1 Cl−/HCO−3 exchanger binds carbonic anhydrase IV. J. Biol. Chem. 277, 25239-25246. doi: ... Not only that most of the H+ and HCO−3 carrying transporters interact with one or several isoforms of carbonic anhydrase, the ...
... carbonic anhydrase has not only been found in virtually all mammalian tissues but is also … ... Carbonic anhydrases catalyze the reversible hydration of CO(2) [CO(2)+H(2)Oright harpoon over left harpoon HCO(3)(-)+H(+)]. ... Prokaryotic Carbonic Anhydrases FEMS Microbiol Rev. 2000 Oct;24(4):335-66. doi: 10.1111/j.1574-6976.2000.tb00546.x. ... some prokaryotes contain multiple genes encoding carbonic anhydrases from the same class. The presence of multiple carbonic ...
Carbonic Anhydrase I from human erythrocytes for your research needs. Find product specific information including CAS, MSDS, ... Carbonic Anhydrase I from human erythrocytes Synonym: Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase Isozyme I ... Carbonic Anhydrase, Cell Signaling Enzymes, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Human Carbonic Anhydrase, ... Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). ...
A key component to this tumor microenvironment is carbonic anhydrase IX (CA IX). Knockdown of CA IX expression or inhibition of ... Keywords: carbonic anhydrase IX; tumor hypoxia; prodrug; sulfonamide; RNAi-technology; cancer carbonic anhydrase IX; tumor ... Mahon, B.P.; Pinard, M.A.; McKenna, R. Targeting Carbonic Anhydrase IX Activity and Expression. Molecules 2015, 20, 2323-2348. ... A key component to this tumor microenvironment is carbonic anhydrase IX (CA IX). Knockdown of CA IX expression or inhibition of ...
... such as the Carbonic Anhydrases (CAs, EC 4.2.1.1). CAs reversibly catalyze the fundamental reaction of CO2 hydration to ... Keywords: carbonic anhydrase inhibitors (CAIs); metalloenzymes; phenols; polyphenols; flavonoids carbonic anhydrase inhibitors ... Phenols and Polyphenols as Carbonic Anhydrase Inhibitors by Anastasia Karioti 1,*, Fabrizio Carta 2. and Claudiu T. Supuran 2,* ... Karioti, A.; Carta, F.; Supuran, C.T. Phenols and Polyphenols as Carbonic Anhydrase Inhibitors. Molecules 2016, 21, 1649. ...
Elevated serum anti-carbonic anhydrase II antibodies in patients with ulcerative colitis ... The aim of this study was to evaluate the presence of anti-carbonic anhydrase (CA) I and anti-CA II antibodies in a series of ...
Rabbit recombinant monoclonal Carbonic Anhydrase IX antibody [SP106] validated for IHC, Flow Cyt and tested in Human. Immunogen ... Anti-Carbonic Anhydrase IX antibody [SP106]. See all Carbonic Anhydrase IX primary antibodies. ... Belongs to the alpha-carbonic anhydrase family.. Contains 1 alpha-carbonic anhydrase domain. ... Flow cytometric analysis of rabbit anti-Carbonic Anhydrase IX (SP106) antibody ab105226 (1/100) in HT29 cells (green) compared ...
Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related ... Human carbonic anhydrases and carbonic anhydrase deficiencies Annu Rev Biochem. 1995;64:375-401. doi: 10.1146/annurev.bi. ... Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related ...
References for Abcams Anti-Carbonic Anhydrase IX antibody (ab10471). Please let us know if you have used this product in your ...
Compare carbonic anhydrase 8 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, ... carbonic anhydrase 8 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool for ... Your search returned 19 carbonic anhydrase 8 ELISA ELISA Kit across 5 suppliers. ...
  • Inhibitors of carbonic anhydrase are used to treat glaucoma, the excessive build up of water in the eyes. (wikipedia.org)
  • X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural determinants of high affinity binding in the nanomolar regime. (rcsb.org)
  • Generally carbonic anhydrase inhibitors are used to treat epilepsy , glaucoma , mountain sickness, and is used as a diuretic. (drugs.com)
  • Carbonic anhydrase inhibitors decrease aqueous production by inhibiting ion transport associated with the secretion of aqueous humor. (aao.org)
  • Osmotic agents and carbonic anhydrase inhibitors are part of established protocols at many centers. (tripdatabase.com)
  • Müller cells have bicarbonate-related transport mechanisms that control movement of potassium and sodium ions (and thus fluid), partly explaining the role for carbonic anhydrase inhibitors such as acetazolamide in the treatment of cystoid macular edema. (tripdatabase.com)
  • 1.Cowan RA, Hartnell GG, Lowdell CP, Baird IM, Leak AM. Metabolic acidosis induced by carbonic anhydrase inhibitors and salicylates in patients with normal renal function. (webmd.com)
  • Toxicity of combined therapy with carbonic anhydrase inhibitors and aspirin. (webmd.com)
  • Carbonic anhydrase inhibitors are used to treat glaucoma. (mayoclinic.org)
  • Medications used to decrease aqueous production include beta-blockers (topical), carbonic anhydrase inhibitors (topical and/or oral), and alpha 2-agonists. (medscape.com)
  • Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors (Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, and Claudiu T. (thefreedictionary.com)
  • X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design (Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. (thefreedictionary.com)
  • Topical carbonic anhydrase inhibitors (dorzolamide, brinzolamide) are used as second-line therapy in the treatment of POAG. (thefreedictionary.com)
  • Many current treatments to lower intraocular pressure (IOP) associated with glaucoma -- beta blockers and carbonic anhydrase inhibitors --work by suppressing the production or inflow of fluid (aqueous humor). (thefreedictionary.com)
  • Glaucoma Pharmaceuticals Markets, forecasts the market and identifies key issues, trends, and competitive analysis for such products as: pilocarpine drugs, andrenergic agonists, beta blockers, carbonic anhydrase inhibitors (CAI) and prostaglandin analogues. (thefreedictionary.com)
  • Which medications in the drug class Antiglaucoma, Carbonic Anhydrase Inhibitors are used in the treatment of Sturge-Weber Syndrome? (medscape.com)
  • Carbonic anhydrase inhibitors typically have a weaker effect than beta blockers. (medscape.com)
  • Carborane-based compounds have emerged as promising lead structures for the development of carbonic anhydrase (CA) inhibitors. (linkos.cz)
  • Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. (thefreedictionary.com)
  • Water permeability of AQP1 cRNA injected oocytes was inhibited by three different carbonic anhydrase inhibitors. (arvojournals.org)
  • TY - JOUR T1 - 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII. (unboundmedicine.com)
  • Recently, carbonic anhydrase (CA) inhibitors have been proposed as a potential new class of antitumor agents. (aspetjournals.org)
  • Structure-activity relationships rationalize affinity trends observed during the development of brinzolamide (Azopt), the newest carbonic anhydrase inhibitor approved for the treatment of glaucoma. (rcsb.org)
  • Carbonic anhydrase inhibitor anticonvulsants inhibit the enzyme carbonic anhydrase. (drugs.com)
  • dorzolamide/timolol) Alpha agonist/ carbonic anhydrase inhibitor (eg, brimonidine/brinzolamide) Laser therapy Laser can be used as primary or adjunctive treatment. (tripdatabase.com)
  • This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. (springer.com)
  • Dorzolamide is a reversible carbonic anhydrase inhibitor that may decrease aqueous humor secretion, causing a decrease in IOP. (medscape.com)
  • Intrinsic thermodynamics of sulfonamide inhibitor binding to human carbonic anhydrases I and II. (sigmaaldrich.com)
  • The purpose of this paper is to present a novel ophthalmic composition comprising a hyperbranched polymer with carbonic anhydrase inhibitor (CAI). (arvojournals.org)
  • Earlier reports have claimed that acetazolamide, a carbonic anhydrase (CA) inhibitor, inhibits AQP1 activity. (arvojournals.org)
  • Carbonic anhydrase 9 (CA9/CAIX) is an enzyme that in humans is encoded by the CA9 gene . (wikipedia.org)
  • Carbonic anhydrase VA deficiency is caused by mutations in the CA5A gene. (medlineplus.gov)
  • This gene provides instructions for making the carbonic anhydrase VA enzyme, which helps convert carbon dioxide to a substance called bicarbonate. (medlineplus.gov)
  • Mutations in the CA5A gene result in absent or impaired carbonic anhydrase VA enzyme function, leading to reduced bicarbonate production. (medlineplus.gov)
  • Studies suggest that a related enzyme produced from the CA5B gene may increasingly compensate for the lack of carbonic anhydrase VA as affected individuals mature, which may result in a reduced risk of metabolic crisis and acute encephalopathy after childhood. (medlineplus.gov)
  • A gene homologous to chloroplast carbonic anhydrase (icfA) is essential to photosynthetic carbon dioxide fixation by Synechococcus PCC7942. (ebi.ac.uk)
  • Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families. (ebi.ac.uk)
  • Lai LW, Chan DM, Erickson RP, Hsu SJ, Lien YHH (1998) Correction of renal tubular acidosis in carbonic anhydrase II-deficient mice with gene therapy. (springer.com)
  • Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes and several homologous, CA- related proteins. (nih.gov)
  • SHUES1 was the presence of carbonic anhydrase gene in it. (frontiersin.org)
  • A gene on chromosome 16q22.1 that encodes a carbonic anhydrase, a zinc metalloenzyme that catalyses the reversible hydration of carbon dioxide. (thefreedictionary.com)
  • The protein encoded by this gene is one of several isozymes of carbonic anhydrase. (thermofisher.com)
  • Using a paleogenomics approach, including gene- and protein-expression techniques and phylogenetic reconstruction, we show that a molecular component of this toolkit was the precursor to the α-carbonic anhydrases (α-CAs), a gene family used by extant animals in a variety of fundamental physiological processes. (sciencemag.org)
  • The CA8 gene encodes carbonic anhydrase VIII (CARP VIII), which is part of a family of zinc metalloenzymes that catalyze the reversible hydration of bicarbonate. (cags.org.ae)
  • Nonetheless, the gene product continues to carry a carbonic anhydrase designation because it showed a clear sequence identity to other members of the carbonic anhydrase gene family. (cags.org.ae)
  • Carbonic anhydrase II deficiency syndrome or Marble brain disease (MBD) is caused by autosomal recessive mutations in the human carbonic anhydrase II (HCA II) gene. (diva-portal.org)
  • The rare disease marble brain disease (MBD) also known as carbonic anhydrase II deficiency syndrome (CADS) can manifest in carriers of point mutations in the human carbonic anhydrase II (HCA II) gene. (diva-portal.org)
  • Girentuximab , an antibody to carbonic anhydrase IX, is an investigational agent in clinical trials for renal cell carcinoma . (wikipedia.org)
  • Flow cytometric analysis of rabbit anti-Carbonic Anhydrase IX (SP106) antibody ab105226 (1/100) in HT29 cells (green) compared to negative control of rabbit IgG (blue). (abcam.com)
  • We offer Carbonic Anhydrase IX/CA9 Antibody Pairs for use in common research applications: Sandwich ELISA. (novusbio.com)
  • Each Carbonic Anhydrase IX/CA9 Antibody Pair is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Our Carbonic Anhydrase IX/CA9 Antibody Pairs can be used in a variety of model species: Human. (novusbio.com)
  • Choose from our Carbonic Anhydrase IX/CA9 Antibody Pairs. (novusbio.com)
  • Carbonic Anhydrase VB/CA5B Polyclonal antibody specifically detects Carbonic Anhydrase VB/CA5B in Human samples. (fishersci.com)
  • The following product was used in this experiment: Carbonic Anhydrase VI Monoclonal Antibody (401809) from Thermo Fisher Scientific, catalog # MA5-24136, RRID AB_2609157. (thermofisher.com)
  • The following product was used in this experiment: Carbonic Anhydrase II Recombinant Rabbit Monoclonal Antibody (2) from Thermo Fisher Scientific, catalog # MA5-30206, RRID AB_2785968. (thermofisher.com)
  • This antibody has specificity for Mouse Carbonic Anhydrase II/CA2. (thermofisher.com)
  • IHC-P analysis of human spleen using GTX88385 Carbonic Anhydrase 1 antibody, Internal. (genetex.com)
  • WB analysis of human liver lysate using GTX88385 Carbonic Anhydrase 1 antibody, Internal. (genetex.com)
  • CAIX is a transmembrane protein and is a tumor-associated carbonic anhydrase isoenzyme. (wikipedia.org)
  • This superfamily also includes the Bacillus subtilis protein YbcF that does not seem to be able to bind zinc, which all carbonic anhydrases are thought to require, and a carbon disulfide hydrolase from acidothermophilic archaeon Acidianus, which has a typical carbonic anhydrase fold and active site but does not use CO(2) as a substrate [ PMID: 22012399 ]. (ebi.ac.uk)
  • A carbonic anhydrase-like domain with striking homology to that of the alpha class carbonic anhydrases is also found in receptor-type tyrosine-protein phosphatase gamma and zeta. (ebi.ac.uk)
  • Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. (ebi.ac.uk)
  • In every living organism, the protein family of carbonic anhydrases regulate a broad variety of homeostatic processes. (biomedsearch.com)
  • People who hyperventilate deplete their levels of red cell carbonic anhydrase and the ratio between the activity and the protein gives us a good indication of whether or not hyperventilation is a problem. (drmyhill.co.uk)
  • moreover, a protein cross-reacting to antiserum raised against the γ carbonic anhydrase from Methanosarcina thermophila was detected. (asm.org)
  • Carbonicanhydrase is a metallo-protein containing zinc. (thefreedictionary.com)
  • The most critical function of Carbonic anhydrase is said to preserve acid-base balance in blood and other tissues, and to help convey carbon dioxide of tissues. (news-medical.net)
  • The effect of carbonic anhydrase inhibition with acetazolamide (Acz, 10 mg/kg) on the ventilatory response to an abrupt switch into hyperoxia (end-tidal PO2 = 450 Torr) and hypoxia (end-tidal PO2 = 50 Torr) was examined in five male subjects [30 +/- 3 (SE) yr]. (biomedsearch.com)
  • Several aromatic/heterocyclic sulfonamide scaffolds have been used to synthesize compounds incorporating NO-donating moieties of the nitrate ester type, which have been investigated for the inhibition of five physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms: hCA I (offtarget), II, IV and XII (antiglaucoma targets) and IX (antitumor target). (rcsb.org)
  • Band3), the Na + /H + exchanger NHE1, the Na + /HCO − 3 cotransporter NBCe1, and various monocarboxylate transporters (MCTs) have been demonstrated to physically and/or functionally interact with isoforms of carbonic anhydrase (CA) to form a "transport metabolon. (frontiersin.org)
  • There are 15 carbonic anhydrase isoforms in humans (belonging to the α subgroup) [ 5 ]. (hindawi.com)
  • Carbonic anhydrases from mammals (including the 10 active human isoforms) ( 22 , 39 ) together with the two periplasmic enzymes from the unicellular green alga Chlamydomonas reinhardtii ( 16 , 17 ) belong to the α class. (asm.org)
  • Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. (nih.gov)
  • Inhibition studies of physiologically relevant human carbonic anhydrase (CA, EC 4.2.1.1) isoforms, such as CA I, II, IX, XII and XIV with these compounds are reported. (nih.gov)
  • The carbonic anhydrases (or carbonate dehydratases) form a family of enzymes that catalyze the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). (wikipedia.org)
  • Carbonic anhydrase is one of the fastest enzymes, and its rate is typically limited by the diffusion rate of its substrates. (wikipedia.org)
  • The carbonic anhydrase VA enzyme is particularly important in the liver, where it provides bicarbonate needed by four enzymes in the energy-producing centers of cells (mitochondria). (medlineplus.gov)
  • Insufficient bicarbonate results in impaired control of acid-base balance and reduces the activity of the four affected mitochondrial enzymes, resulting in the various biochemical abnormalities associated with carbonic anhydrase VA deficiency. (medlineplus.gov)
  • Carbonic anhydrases (CAs, EC 4.2.1.1) are zinc enzymes acting as efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate. (nih.gov)
  • Carbonic anhydrases constitute a group of enzymes that catalyse reversible hydration of carbon dioxide leading to the formation of bicarbonate and proton. (hindawi.com)
  • Carbonic anhydrase (CA) are enzymes which catalyze the interconversion of CO2 and water to bicarbonate and proton. (proteopedia.org)
  • There are two enzymes, urease, and carbonic anhydrase, that play an important role in the MICP process. (frontiersin.org)
  • The structure of the prototype γ carbonic anhydrase from M. thermophila has recently been solved and found to be entirely different from those of the α-class enzymes ( 31 ). (asm.org)
  • Although a three-dimensional structure has yet to be determined for a β carbonic anhydrase, extended X-ray absorption fine structure and circular dichroism of the plant enzyme indicate that the zinc coordination and overall structure are quite different from those for either the α- or γ-class enzymes ( 10 , 42 ). (asm.org)
  • Carbonic anhydrase (carbonate dehydratase) is a family of metalloenzymes (enzymes that contain one or more metal atoms as a functional component of the enzyme) that catalyze the rapid (and reversible) conversion of carbon dioxide to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. (prospecbio.com)
  • Carbonic anhydrase (CA) (EC 4.2.1.1) enzymes catalyze the reversible hydration of CO 2 , a reaction that is important in many physiological processes. (plantphysiol.org)
  • Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous enzymes that catalyze the reversible hydration reaction of carbon dioxide. (uta.fi)
  • The CAIs inhibit the enzyme carbonic anhydrase, which in turn, reduces aqueous humor formation. (medrounds.org)
  • Dorzolamide inhibits carbonic anhydrase in the ciliary processes, which decreases aqueous humor formation. (medscape.com)
  • The enzyme Carbonic anhydrase 2 (CA2) belongs to the enzyme group that catalyzes rapid inter-conversion of carbon dioxide and water to carbonic acid, bicarbonate, and protons (CO 2 + H 2 O to HCO 3 + H), a reaction that takes place rather gradually in the absence of a catalyst. (news-medical.net)
  • In C 4 photosynthesis, the enzyme carbonic anhydrase (CA) hydrates CO 2 to form bicarbonate, which is the first catalyzed step in the C 4 photosynthetic pathway ( Badger, 1994 ). (plantphysiol.org)
  • Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. (ihcworld.com)
  • An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water. (thefreedictionary.com)
  • carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO 2 + H 2 O ⇄H 2 CO 3 . (thefreedictionary.com)
  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. (wikipedia.org)
  • Carbonic anhydrases ( EC:4.2.1.1 ) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. (ebi.ac.uk)
  • The majority of carbonic anhydrases enclose a zinc ion in their active site and thus is categorized as metalloenzymes. (news-medical.net)
  • Carbonic anhydrases (CA) are zinc metalloenzymes that are present in prokaryotes and eukaryotes. (biomedsearch.com)
  • The carbonic anhydrases (CAs) are a family of metalloenzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate and a proton. (coronetbooks.com)
  • Human carbonic anhydrase (CA) I and II are cytosolic proteins, where their expression disorders can cause diseases such as glaucoma, edema, epilepsy or cancer. (sigmaaldrich.com)
  • The Arabidopsis CAH1 alpha-type carbonic anhydrase is one of the few plant proteins known to be targeted to the chloroplast through the secretory pathway. (diva-portal.org)
  • Carbonic anhydrase isozyme CA3 protects cells against oxidative stress. (scirp.org)
  • By this second component of the mechanism, the same stimulus directly acts on the carbonic anhydrase I isozyme (that might be functionally coupled with adrenergic receptors), so that its activation ensures an adequate pH for stimulus-receptor coupling for signal transduction into the cell, resulting in vasoconstriction. (scielo.br)
  • Carbonic anhydrase isozyme II (CA II) is a cytosolic enzyme that is highly expressed in most organs, including the brain, where it is mainly located in the oligodendrocytes. (pubmedcentralcanada.ca)
  • A recent study on dendritic cell therapy for melanoma patients identified carbonic anhydrase isozyme II (CA II) as a potential target antigen. (pubmedcentralcanada.ca)
  • Structure and mechanism of carbonic anhydrase. (ebi.ac.uk)
  • Lindskog S. Structure and mechanism of carbonic anhydrase. (proteopedia.org)
  • A review is provided focusing on the sequence of elementary reactions ensuing a catalytic reaction (catalytic mechanism) of carbonic anhydrase. (novapublishers.com)
  • Ingle R, Colman B (1976) The relationship between carbonic anhydrase activity and glycolate excretion in the blue-green alga Coccochloris peniocystis . (springer.com)
  • In this compilation, the authors address the relationship between carbonic anhydrase IX and hypoxia. (novapublishers.com)
  • La cuticule de l'écrevisse Procambarus clarkii (Girard, 1852) contient plusieurs isoenzymes extracellulaires de l'anhydrase carbonique (CA), qui ont été isolées et purifiées par chromatographie. (brillonline.com)
  • Les poids moléculaires estimées en utilisant PAGE, ont révélé une isoenzyme avec un poids moléculaire de 29 kDa, qui est analogue à celle trouvée chez les Vertébrés, et deux plus grands isoenzymes (53 et 66 kDa). (brillonline.com)
  • In addition, there are given some chemical and kinetic basis and technical details related to phenolic antioxidant compounds and carbonic anhydrase isoenzymes. (eurekaselect.com)
  • Class one being alpha carbonic anhydrase which is found in mammals, class two being beta carbonic anhydrase which is found in bacteria and plants and lastly, class three which is gamma carbonic anhydrase which is found in methanogen bacteria in hot springs. (wikipedia.org)
  • For full entry on γ-carbonic anhydrase see Gamma Carbonic Anhydrase . (proteopedia.org)
  • Belongs to the alpha-carbonic anhydrase family. (abcam.com)
  • Contains 1 alpha-carbonic anhydrase domain. (abcam.com)
  • During the past 10 years, immunocytochemical methods have been used for localization of carbonic anhydrase (CA) in glial cells and myelin in the mammalian central nervous system. (springer.com)
  • Graham D, Reed M (1971) Carbonic anhydrase and the regulation of photosynthesis. (springer.com)
  • Carbonic anhydrase is a metalloenzyme that requires Zn as a cofactor and is involved in diverse biological processes including pH regulation, CO 2 transfer, ionic exchange, respiration, CO 2 photosynthetic fixation, and stomatal closure. (scielo.cl)
  • These studies have also demonstrated the involvement of carbonic anhydrase in the regulation of vascular and secretory processes in the organism (14). (scielo.br)
  • cDNA cloning, sequence, and expression of carbonic anhydrase in Chlamydomonas reinhardtii: regulation by environmental CO2 concentration. (pnas.org)
  • Carbonic anhydrase (CA) catalyzes the hydration of CO 2 , and its activity has been linked to stomatal aperture regulation in eudicots. (plantphysiol.org)
  • Carbonic anhydrase is a zinc-containing enzyme that catalyzes the reversible hydration of CO 2 (CO 2 + H 2 O ⇋ HCO 3 − + H + ). In eukaryotes, the enzyme participates in various physiological functions, which include the interconversion of CO 2 and HCO 3 − during photosynthesis and intermediary metabolism, facilitated diffusion of CO 2 , pH homeostasis, and ion transport ( 5 , 45 ). (asm.org)
  • Identification of a carbonic anhydrase-like domain in the extracellular region of RPTP gamma defines a new subfamily of receptor tyrosine phosphatases. (ebi.ac.uk)
  • In the CA1 region of the hippocampus, stimulation of the Schaffer collaterals elicits an alkaline pH e transient in stratum radiatum that is limited by extracellular carbonic anhydrase (ECA). (jneurosci.org)
  • This form of alkalosis increases when extracellular carbonic anhydrase (ECA) is inhibited by drugs such as benzolamide ( Chen and Chesler, 1992b ). (jneurosci.org)
  • CAIX is a transmembrane isoform of carbonic anhydrase with an extracellular-facing catalytic site and therefore is well positioned to act in the control of tumor pH, and is overexpressed in various solid tumors. (linkos.cz)
  • The cuticle of the freshwater crayfish, Procambarus clarkii (Girard, 1852), has several extracellular, cuticular isozymes for carbonic anhydrase (CA) which were isolated and purified via affinity chromatography. (brillonline.com)
  • We have hypothesized that carbonic anhydrases (CAs) play a role in stabilizing both intracellular and extracellular pH to favor cancer progression and metastasis. (portlandpress.com)
  • Among these genes, carbonic anhydrase isoform 9 (CA9) is highly overexpressed in many types of cancer especially in high grade brain cancer like GBM. (nih.gov)
  • Carbonic anhydrase II (CAII)-deficient mice were created to study the syndrome of CAII deficiency in humans including osteopetrosis, renal tubular acidosis, and cerebral calcification. (springer.com)
  • The platelet carbonic anhydrase II (CAII) was described for the first time in the '80s of the last century. (hindawi.com)
  • Ohlsson A, Cumming WA, Paul A, Sly WS (1986) Carbonic anhydrase-II deficiency syndrome -recessive osteopetrosis with renal tubular-acidosis and cerebral calcification. (springer.com)
  • Lewis SE, Erickson RP, Barnett LB, Venta PJ, Tashian RE (1988) N-Ethyl-N-nitrosourea induced null mutation at the mouse car-2 locus-an animal-model for human carbonic anhydrase-II deficiency syndrome. (springer.com)
  • Carbonic anhydrase II deficiency syndrome is a recessive disorder that causes osteopetrosis, renal acidosis and cerebral calcification. (proteopedia.org)
  • The delta cynT chromosomal mutant expressed an active cyanase but no active carbonic anhydrase. (asm.org)
  • The main role of carbonic anhydrase in humans is to catalyze the conversion of carbon dioxide to carbonic acid and back again. (wikipedia.org)
  • Therefore, the role of carbonic anhydrase depends on where it is found in the body. (wikipedia.org)
  • Hogetsu D, Miyachi S (1979) Role of carbonic anhydrase in photosynthetic CO 2 fixation in Chlorella . (springer.com)
  • Tashian RE (1992) Genetics of the mammalian carbonic-anhydrases. (springer.com)
  • Mammalian carbonic anhydrase is monomeric and is a part of the alpha class. (news-medical.net)
  • Prokaryotic carbonic anhydrases. (ebi.ac.uk)
  • Carbonic anhydrase is present in prokaryotic and eukaryotic cells. (hindawi.com)
  • Carbonic anhydrase is nearly ubquitous in highly evolved eukaryotes, but until recently the enzyme was thought to play a minor role in prokaryotic physiology ( 48 ). (asm.org)
  • Four prokaryotic carbonic anhydrases from species in the Bacteria domain, two belonging to the α class and two belonging to the β class, have been described ( 13 , 20 , 49 , 50 ). (asm.org)
  • A key component to this tumor microenvironment is carbonic anhydrase IX (CA IX). (mdpi.com)
  • Carbonic anhydrase helps maintain acid-base homeostasis, regulate pH, and fluid balance. (wikipedia.org)
  • Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. (springer.com)
  • Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. (biomedsearch.com)
  • Chemometrical-electrochemical investigation for comparing inhibitory effects of quercetin and its sulfonamide derivative on human carbonic anhydrase II: Theoretical and experimental evidence. (bioportfolio.com)
  • This paper reports results of a valuable study on investigation of inhibitory effects of the sulfonamide derivative of quercetin (QD) on human carbonic anhydrase II (CA-II) by electrochemical and chemometrical approaches. (bioportfolio.com)
  • Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity. (bioportfolio.com)
  • The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. (bioportfolio.com)
  • Moreover, in 2007, it was presented that also in rheumatoid arthritis there are present aCAAs in serum, showing affinity to bind to carbonic anhydrase III in synovial membranes [ 16 ]. (hindawi.com)
  • We report here the use of 19 F pseudocontact shift (PCS) NMR as a method to determine fluorine positions of high affinity ligands bound within the drug target human carbonic anhydrase II with high accuracy. (rsc.org)
  • The Human Recombinant Carbonic Anhydrase (CA) 2 preserves acid-base balance in blood and other tissues. (news-medical.net)
  • Carbonic anhydrase III Human Recombinant produced in E.Coli, and having a molecular mass of 33.9 kDa. (prospecbio.com)
  • carbonic anhydrase assists Carbonic Anhydrase I to move CO2 to and from tissues. (prospecbio.com)
  • Carbonic anhydrase, a zinc enzyme catalyzing the interconversion of carbon dioxide and bicarbonate, is nearly ubiquitous in the tissues of highly evolved eukaryotes. (asm.org)
  • Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. (ihcworld.com)
  • Erythrocytic carbonic anhydrase provides for the bonding of CO 2 with blood in the tissues and for its rapid release in the lungs or branchia. (thefreedictionary.com)
  • However, carbonic anhydrase attenuated post-exercise increases in PaCO2 and decreases in pHa by about 50 % without altering arterial O2 variables, red cell swelling or the intracellular pH of the brain or muscle tissues. (biologists.org)
  • β-carbonic anhydrase are found in prokaryotes. (proteopedia.org)
  • These results show that β-class carbonic anhydrases extend not only into the Archaea domain but also into the thermophilic prokaryotes. (asm.org)
  • Interestingly, the autoantibodies against carbonic anhydrase II might be produced in humans due to cross-reactivity with carbonic anhydrase of Helicobacter pylori [ 28 ]. (hindawi.com)
  • Carbonic anhydrase in bacteria. (nih.gov)
  • γ-carbonic anhydrase are found in methane-producing bacteria. (proteopedia.org)