Carbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.AcetalsCarbazoles: Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Anterior Thalamic Nuclei: Three nuclei located beneath the dorsal surface of the most rostral part of the thalamus. The group includes the anterodorsal nucleus, anteromedial nucleus, and anteroventral nucleus. All receive connections from the MAMILLARY BODY and BRAIN FORNIX, and project fibers to the CINGULATE BODY.Mamillary Bodies: A pair of nuclei and associated gray matter in the interpeduncular space rostral to the posterior perforated substance in the posterior hypothalamus.Septal Nuclei: Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.Autoradiography: The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Thalamic Nuclei: Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Encephalitis Viruses, Japanese: A subgroup of the genus FLAVIVIRUS which comprises a number of viral species that are the etiologic agents of human encephalitis in many different geographical regions. These include Japanese encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE), St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), Murray Valley encephalitis virus (ENCEPHALITIS VIRUS, MURRAY VALLEY), and WEST NILE VIRUS.Flavivirus: A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Azirines: Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Spiro Compounds: A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.Trifluridine: An antiviral derivative of THYMIDINE used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to HERPES SIMPLEX virus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p557)Alkylation: The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.Perilla frutescens: A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.ArgentinaTheilovirus: A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.Abstracting and Indexing as Topic: Activities performed to identify concepts and aspects of published information and research reports.Data Mining: Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Ethyldimethylaminopropyl Carbodiimide: Carbodiimide cross-linking reagent.MPTP Poisoning: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Infant Formula: Liquid formulations for the nutrition of infants that can substitute for BREAST MILK.CarbodiimidesMagnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Body Surface Potential Mapping: Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.BenzodiazepinonesReceptors, GABA-A: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.Neurogenic Inflammation: Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.Indole Alkaloids: Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)Silica Gel: A non-crystalline form of silicon oxide that has absorptive properties. It is commonly used as a desiccating agent and as a stationary phase for CHROMATOGRAPHY. The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID.Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.Proline Oxidase: The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrroline-5-carboxylic acid in the presence of oxygen and water. The action is not reversible. The specific activity of proline oxidase increases with age. EC 1.5.3.-.

Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. (1/508)

CA1 pyramidal cells were voltage clamped, and GABA was applied to individual cells with a modified U-tube, rapid drug application system. With Vh = -50 mV, inward currents elicited by 10 microM GABA were inhibited by GABAA receptor (GABAR) antagonists and were baclofen insensitive, suggesting that GABA actions on isolated CA1 pyramidal cells were GABAR mediated. GABA concentration-response curves averaged from all cells were fitted best with a two-site equation, indicating the presence of at least two GABA binding sites, a higher-affinity site (EC50-1 = 11.0 microM) and a lower-affinity site (EC50-2 = 334.2 microM), on two or more populations of cells. The effects of GABAR allosteric modulators on peak concentration-dependent GABAR currents were complex and included monophasic (loreclezole) or multiphasic (diazepam) enhancement, mixed enhancement/inhibition (DMCM, zolpidem) or multiphasic inhibition (zinc). Monophasic (70% of cells) or biphasic (30% of cells) enhancement of GABAR currents by diazepam suggested three different sites on GABARs (EC50-1 =1.8 nM; EC50-2 = 75.8 nM; EC50-3 = 275.9 nM) revealing GABAR heterogeneity. The imidazopyridine zolpidem enhanced GABAR currents in 70% of cells with an EC50 = 222.5 nM, suggesting a predominance of moderate affinity alpha2 (or alpha3-) subtype-containing BZ Type IIA receptors. A small fraction of cells (10%) had a high affinity for zolpidem, something that is suggestive of alpha1 subtype-containing BZ Type I receptors. The remaining 30% of cells were insensitive to or inhibited by zolpidem, suggesting the presence of alpha5 subtype-containing BZ Type IIB receptors. Whether BZ Type I and Type II receptors coexist could not be determined. The beta-carboline methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) inhibited GABAR currents in all cells at midnanomolar concentrations, but in addition, potentiated GABAR currents in some cells at low nanomolar concentrations, characterizing two groups of cells, the latter likely due to functional assembly of alpha5betaxgamma2GABARs. In all cells, GABAR currents were moderately sensitive (EC50 = 9 microM) to loreclezole, consistent with a relatively greater beta3 subtype, than beta1 subtype, subunit mRNA expression. Two populations of cells were identified based on their sensitivities to zinc(IC50 = 28 and 182 microM), suggesting the presence of at least two GABAR isoforms including alpha5beta3gamma2 GABARs. Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABAR isoforms.  (+info)

Occurrence of stereoisomers of 1-(2'-pyrrolidinethione-3'-yl)- 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in fermented radish roots and their different mutagenic properties. (2/508)

Stereoisomers of the tetrahydro-beta-carboline derivative, 1-(2-pyrrolidinethione)-3-yl)-1,2,3,4-tetrahydro-beta-carboline- 3-carboxylic acid (PTCC), were formed from L-tryptophan with 4-methylthio-3-butenyl isothiocyanate, and their mutagenic properties and contents in different types of the radish products were studied. The isomers were identified as (1S*, 3S*, 3R*)- and (1R*, 3S*, 3R*)-PTCCs; the former was found as the major compound but had no mutagenic activity, while the latter was mutagenic toward Salmonella typhimurium TA 98 in the presence of a rat microsomal fraction. Both (1S*, 3S*, 3R*)- and (1R*, 3S*, 3R*)-PTCC were detected in a ratio of about 4:1 in a product fermented for 8 months, but only a trace was apparent in products manufactured within a few weeks.  (+info)

Heterocyclic aromatic amines induce DNA strand breaks and cell transformation. (3/508)

Heterocyclic aromatic amines (HAAs), formed during the cooking of foods, are known to induce tumours in rodent bioassays and may thus contribute to human cancer risk. We tested six HAAs in a morphological transformation assay and in three in vitro genotoxicity assays. The morphological transforming abilities of HAAs were tested, in the presence of rat-liver S9, in the C3H/M2 fibroblast cell line. Concentration levels of 50 microM 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (8-MeIQx), 100 microM 2-amino-3,4,8-trimethylimidazo-[4,5-f]quinoxaline (4,8-DiMeIQx), 50 microM 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 100 microM 2-amino-9H-pyrido[2,3-b]indole (AalphaC), 100 microM 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) and 15 microM 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced maximum transformation potencies of 5.5, 6.6, 6.3, 5.2, 7.3 and 9.2 transformed foci per 10(4) surviving cells, respectively. Bacterial mutagenic activity was determined in the presence of rat-liver S9 using the Salmonella typhimurium reverse-mutation assay employing strain YG1019. Mutagenic potencies of 3800 revertants (revs)/ng with 8-MeIQx, 2900 revs/ng with 4,8-DiMeIQx, 3480 revs/ng with IQ, 1.6 revs/ng with AalphaC, 2.9 revs/ng with MeAalphaC and 5 revs/ng with PhIP were observed. Clastogenic activity in vitro was analysed by the micronucleus assay in metabolically competent MCL-5 cells. Dose-dependent induction of micronuclei was observed for all HAAs tested with 1-5.4% of cells containing micronuclei at 10 ng/ml. Micronucleus induction was in the order 4,8-DiMeIQx > 8-MeIQx > IQ > MeAalphaC > PhIP > AalphaC. DNA strand-breaking activity in MCL-5 cells was measured by the alkaline single cell-gel (comet) assay. The lowest effect doses for significant increases (P < or = 0.0007, Mann-Whitney test) in comet tail length (microm) were 45.5 microg/ml (200 microM) for PhIP, 90.9 microg/ml (410-510 microM) for 4,8-DiMeIQx, IQ, MeAalphaC and AalphaC, and 454.5 microg/ml (2130 microM) for 8-MeIQx. It is not yet clear which of these assays most accurately reflects the genotoxic potential to humans of compounds of this class of environmental carcinogens.  (+info)

Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice. (4/508)

To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1.  (+info)

The fluorescence of scorpions and cataractogenesis. (5/508)

BACKGROUND: Protein cross-linking and fluorescence are widely recognized markers of oxidative aging in human proteins. Oxidative protein aging is a combinatorial process in which diversity arises from the heterogeneity of the targets and is amplified by the nonselective nature of the reactants. The cross-links themselves defy analysis because they are generally embedded in a covalent matrix. Arthropods rely upon oxidative cross-linking in the hardening of the cuticle - a process known as sclerotization. Among arthropods, scorpions are noteworthy in that the process of sclerotization is accompanied by the buildup of strong visible fluorescence. To date, the nature of the fluorescent species has remained a mystery. RESULTS: We have identified one of the soluble fluorescent components of the scorpions Centuroides vittatus and Pandinus imperator as beta-carboline - a tryptophan derivative that has previously been identified by hydrolysis and oxidation of lens protein. We have also shown that beta-carboline-3-carboxylic acid is released from both scorpion exuvia (the shed cuticle) and human cataracts upon hydrolysis, suggesting that the protein-bound beta-carboline and free beta-carboline have common chemical origins. CONCLUSIONS: Cataractogenesis and cuticular sclerotization are disparate oxidative processes - the former is collateral and the latter is constitutive. The common formation of beta-carbolines shows that similar patterns of reactivity are operative. These fundamental mechanisms provide predictive insight into the consequences of human protein aging.  (+info)

Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys. (6/508)

Drugs that bind to benzodiazepine recognition sites of gamma-aminobutyric acid type A receptor complexes may function as agonists in some behavioral assays and as antagonists in other behavioral assays. The present studies compared the effects of the benzodiazepines midazolam, flumazenil, bretazenil, Ro 41-7812, and Ro 42-8773 and the beta-carboline, beta-carboline-3-carboxylate-t-butyl ester (beta-CCt) under two different types of schedule-controlled responding in squirrel monkeys. One group of monkeys responded under a fixed-ratio schedule of stimulus-shock termination, and a second group of monkeys responded under a multiple fixed-ratio schedule of food presentation involving suppressed and nonsuppressed behavior. Under the schedule of stimulus-shock termination, midazolam produced dose-related decreases in response rate, and these effects were surmountably antagonized by flumazenil, bretazenil, Ro 41-7812, Ro 42-8773, and beta-CCt. Schild plot analysis of these data revealed the following mean pA(2) values: flumazenil, 7.18; bretazenil, 7.62; Ro 41-7812, 7. 06; Ro 42-8773, 6.95. Apparent pA(2) values were not calculated for beta-CCt because the CL of the slope of the Schild plot included positive values. Under the multiple schedule, midazolam, bretazenil, and Ro 42-8773 dose-dependently increased rates of suppressed responding, whereas flumazenil, Ro 41-7812, and beta-CCt had no significant rate-altering effects. Flumazenil antagonized the antisuppressant effects of midazolam and bretazenil; however, individual variability in these effects prohibited the determination of apparent pA(2) values. These results indicate that in vivo pA(2) values may be determined for benzodiazepine-site ligands. These results further demonstrate that some benzodiazepine-site ligands, e. g., bretazenil and Ro 42-8773, may function as both agonists and as competitive antagonists in vivo.  (+info)

Dual mode of stimulation by the beta-carboline ZK 91085 of recombinant GABA(A) receptor currents: molecular determinants affecting its action. (7/508)

In electrophysiological measurements the beta-carboline ethyl 6-benzyloxy-beta-carboline-3-carboxylate (ZK 91085) acts as a positive allosteric modulator on rat recombinant alpha1beta2gamma2 GABA(A) receptors and binds with high affinity (IC50-1.5 nM) to the [3H]-flunitrazepam site. Flumazenil was able to partially counteract the current modulation. These observations indicate an action of ZK 91085 at the benzodiazepine binding site. At the dual subunit combination alpha1beta2, which lacks the gamma subunit required for benzodiazepine modulation, we still observed a potentiation of GABA currents. Thus ZK 91085 acts via an additional site on the channel. At the subunit combination alpha1beta1, ZK 91085 potentiation is strongly reduced as compared to alpha1beta2. In binding studies, ZK 91085 was able to decrease [35S]-TBPS binding in alpha1beta2gamma2 and alpha1beta2 but not in alpha1beta1. This selectivity of ZK 91085 for receptors containing the beta2 isoform over those containing the beta1 isoform is reminiscent of the action of loreclezole. To identify amino acid residues important for the second type of modulation, we functionally compared wild type alpha1beta2 and mutant receptors for stimulation by ZK 91085. The mutation beta2N265S, that abolishes loreclezole effects, also abolishes ZK 91085 stimulation. The mutation beta2Y62L increased stimulation by ZK 91085 3-4 fold, locating an influencing entity of the second type of action of ZK 91085 at an alpha/beta subunit interface. Structural intermediates of ZK 91085 and the beta-carboline abecarnil, the latter of which only slightly potentiated GABA currents in alpha1/beta2, were analysed to determine structural requirements for modulation. ZK 91085 thus allosterically stimulates the GABA(A) receptor through two sites of action: the benzodiazepine site and the loreclezole site in contrast to classical beta-carbolines, that confer negative allosteric modulation through the benzodiazepine site.  (+info)

Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist. (8/508)

BACKGROUND: No currently available treatment provides consistent relief of irritable bowel syndrome. Colonic sensory and motor function are modulated partly through 5HT3-receptors. AIM: To evaluate effects of the 5HT3-receptor antagonist, alosetron, in irritable bowel syndrome. METHODS: Randomized, double-blind, placebo-controlled, dose-ranging (1, 2, 4, 8 mg b.d. alosetron), 12-week trial in 370 patients with diarrhoea-predominant or alternating constipation and diarrhoea irritable bowel syndrome. Weekly measurement of adequate relief was the key end-point; other irritable bowel syndrome symptoms were collected daily using an electronic phone system. RESULTS: Alosetron (1 mg or 2 mg b.d.) significantly (P < 0.05 vs. placebo) increased the proportion of females, but not males, reporting adequate relief. Stool consistency, frequency and percentage days with urgency improved over placebo (P < 0.05) within the first month with all doses of alosetron, and persisted throughout the trial with all doses in female patients. With 1 mg b.d. alosetron, females had improved stool consistency and urgency within the first week, and adequate relief and improved stool frequency within the first 2 weeks. There was no consistent improvement in bowel function among male patients. CONCLUSION: In female irritable bowel syndrome patients with predominant diarrhoea or alternating constipation and diarrhoea, alosetron is effective in treatment of abdominal pain and discomfort and bowel-related symptoms.  (+info)

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Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity. Article date: 1991/12/1 PubMed ID: 1658234 Journal name: Journal of neurochemistry (ISSN: 0022-3042)
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Calcium signaling is essential for the differentiation of many cell types, including skeletal muscle cells, but its mechanisms remain elusive. Here we demonstrate a crucial role for nicotinic acid adenine dinucleotide phosphate (NAADP) signaling in skeletal muscle differentiation. Although the inositol trisphosphate pathway may have a partial role to play in this process, the ryanodine signaling cascade is not involved. In both skeletal muscle precursors and C2C12, cells interfering with NAADP signaling prevented differentiation, whereas promoting NAADP signaling potentiated differentiation. Moreover, siRNA knockdown of two-pore channels, the target of NAADP, attenuated differentiation. The data presented here strongly suggest that in myoblasts, NAADP acts at acidic organelles on the recently discovered two-pore channels to promote differentiation.
Background We previously showed that colonic mucosal biopsy supernatants from patients with irritable bowel syndrome (IBS) activate neurons of the human submucous plexus, an area with densely packed immune cells. Based on the concept that mucosa-nerve signaling is altered in IBS, we tested in this study whether the nerve sensitizing effect of IBS mucosal biopsy supernatants is more prominent in the submucous than myenteric plexus.. Methods Fast neuroimaging with the voltage-sensitive dye Di-8-ANEPPS was used to record activity of guinea-pig submucous and myenteric neurons after application of constipation (C)- and diarrhea (D)-IBS supernatants (three each) and four supernatants from healthy control subjects. Results are based on recordings from 4731 neurons.. Key Results Control supernatants did not evoke significant responses in submucous or myenteric neurons. In contrast, all IBS supernatants evoked a significant spike discharge (median 3.6 Hz) in 46% of submucous neurons. This activation was ...
Pfau W, Skog K (March 2004). "Exposure to beta-carbolines norharman and harman". Journal of Chromatography B. 802 (1): 115-26. ... "Quantification of the neurotoxic beta-carboline harmane in barbecued/grilled meat samples and correlation with level of ...
... s, carbolines, and related compounds. Part II. A convenient synthesis of tryptamines and β-carbolines". Journal of ...
The β-carboline carboxylic acid subsequently undergoes decarboxylation to produce 1-methyl β-carboline III. Hydroxylation ... indole ring structure that is characteristic of the β-carboline alkaloids. The β-carboline alkaloids include harmine, harmaline ... "β-Carboline alkaloids bind DNA". Journal of Photochemistry and Photobiology B: Biology. 100: 84-91. doi:10.1016/j.jphotobiol. ... Harmine, also known as telepathine, is a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds. It ...
4-tetrahydro-β-carboline; 6-Methoxy-tetrahydronorharman; 6-Methoxy-2,3,4,9-tetrahydro-1H-β-carboline ... 2015 "Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline ( ... "pineal beta-carboline".[2] The biological activity of this molecule is of interest as a potential free radical scavenger, also ... 4-Tetrahydro-β-carboline and its Effect on 5-Hydroxytryptamine Uptake and Release in Blood Platelets". Acta Pharmacol Toxicol. ...
... , or 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a ... Beta-carboline Harmala alkaloid Tryptamine Shulgin, Alexander; Ann Shulgin (September 1997). TiHKAL: The Continuation. Berkeley ... "Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors". Drug ... "β-carboline binding to imidazoline receptors". Drug and Alcohol Dependence. 64 (2): 203-208. doi:10.1016/S0376-8716(01)00123-5 ...
"Synthesis of α-Carboline". Org. Synth. 93: 272. doi:10.15227/orgsyn.093.0272. CS1 maint: Uses authors parameter (link) " ...
Chapman AG, De Sarro GB, Premachandra M, Meldrum BS (September 1987). "Bidirectional effects of beta-carbolines in reflex ...
Oppositines are vasorelaxant beta-carbolines isolated from Neisosperma. Oppositinines A and B: new vasorelaxant beta-carboline ...
Beta-carbolines Psychotria viridis, Beta-carbolines Simira klugei, Beta-carbolines Simira rubra, Beta-carbolines Uncaria ... Beta-carbolines Picrasma crenata, Beta-carbolines Picrasma excelsa, Beta-carbolines Picrasma javanica, Beta-carbolines Vestia ... Beta-carbolines Meconopsis paniculata, Beta-carbolines Meconopsis robusta, Beta-carbolines Meconopsis rudis, Beta-carbolines ... Phalaris aquatica, Beta-carbolines Phalaris arundinacea, Beta-carbolines Nectandra megapotamica, Beta-carbolines Acacia ...
... beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3- ... ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of ... ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine GABAA ... Dodd RH, Ouannès C, Potier MC, Prado de Carvalho L, Rossier J, Potier P (July 1987). "Synthesis of beta-carboline- ...
S. A. Adesanya; M. Chbani; M. Païs; C. Debitus (1992). "Brominated β-Carbolines from the Marine Tunicate Eudistoma album". J. ...
... s are novel cytocidal beta-carbolines isolated from Streptomyces. Abe N, Nakakita Y, Nakamura T, Enoki N, Uchida H ...
"In vitro study of the aromatic hydroxylation of 1-methyltetrahydro-beta-carboline (methtryptoline) in rat". Chem Biol Interact ...
Myers, R. D. (1989). "Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms". ... "Formaldehyde-derived tetrahydroisoquinolines and tetrahydro-beta-carbolines in human urine". Journal of Chromatography B. 683 ( ...
Levels of beta-carbolines and hordenine have also been reported. "Phalaris arundinacea". Germplasm Resources Information ...
... (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak ... File, SE; Pellow, S; Jensen, LH (1986). "Actions of the beta-carboline ZK 93426 in an animal test of anxiety and the holeboard ... Duka, T; Edelmann, V; Schütt, B; Dorow, R (1988). "Beta-carbolines as tools in memory research: human data with the beta- ... Duka, T; Ott, H; Rohloff, A; Voet, B (1996). "The effects of a benzodiazepine receptor antagonist beta-carboline ZK-93426 on ...
The beta-carboline hallucinogens of South America. Journal of Psychoactive Drugs 14(3): 205-220. Grisebach, A.H.R. 1849. ...
... is a bio-active beta-carboline. Wabaidur SM, Lee SH, Alothman ZA, Siddiqui MR, Alam SM (2013). "Second derivative ...
"Exudation of fluorescent b-carbolines from Oxalis tuberosa L. roots" (PDF). Phytochemistry. 61 (5): 539-543. doi:10.1016/S0031- ...
... is a β-carboline isolated from nature. It is readily formed in vivo in humans by O-demethylation of harmine. Abe A, ... Abe A, Yamada H, Moriya S, Miyazawa K (2011). "The β-carboline alkaloid harmol induces cell death via autophagy but not ...
... , also known as tetrahydro-β-carboline and tetrahydronorharmane, is a natural organic derivative of beta-carboline. ... Norharmane harmane beta-Carboline Harmala alkaloid H. Rommelspacher; H. Kauffmann; C. Heyck Cohnitz; H. Coper (1977). " ... Comparison of the inhibition kinetics of tetrahydro-β-carbolines for serotonin and epinephrine reuptake to that of the platelet ...
... is a bioactive beta-carboline harmala alkaloid. Riba, J; McIlhenny, EH; Valle, M; Bouso, JC; Barker, SA (2012 ...
Aug). „4382 DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast". Cancer Biol Ther. 6 (8), ... Herraiz T, González D, Ancín-Azpilicueta C, Arán VJ, Guillén H. (2010). „beta-Carboline alkaloids in Peganum harmala and ... Nov). „Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and ... Jul). „Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities". ...
As a rule, the fewer the β-carbolines, the less the nausea; the more DMT, the more spectacular the visions. The constituents ...
Gremmen, C.; Willemse, B.; Wanner, M. J.; Koomen, G.-J. (2000). "Enantiopure Tetrahydro-β-carbolines via Pictet-Spengler ...
Gremmen, C.; Willemse, B.; Wanner, M. J.; Koomen, G.-J. (2000). "Enantiopure Tetrahydro-β-carbolines via Pictet-Spengler ... 4-tetrahydro-β-carbolines in which a new chiral center at C-1 adopts either a cis or trans configuration towards the C-3 ... 4-tetrahydro-β-carbolines by carbon-13 spectroscopy". J. Am. Chem. Soc. 102 (23): 6976-6984. doi:10.1021/ja00543a012. ...
Novel IKK inhibitors: beta-carbolines.. Castro AC1, Dang LC, Soucy F, Grenier L, Mazdiyasni H, Hottelet M, Parent L, Pien C, ... A screening effort of the endogenous IKK complex allowed us to identify 5-bromo-6-methoxy-beta-carboline as a nonspecific IKK ... Optimization of this beta-carboline natural product derivative resulted in a novel class of selective IKK inhibitors with IC(50 ... In addition, we show that one of these beta-carboline analogues inhibits the phosphorylation of IkappaBalpha and subsequent ...
... connected in series was studied for the simultaneous determination of two tetrahydro-β-carbolines and two β-carbolines. After ... The quantitative ranges were 0.25-80.0 ng mL−1 for both tetrahydro-β-carbolines and 0.1-30.0 ng mL−1 for both β-carbolines. ... Column liquid chromatography Fluorimetric detection Tetrahydro-β-carbolines β-Carbolines This is a preview of subscription ... This treatment not only suppressed the artefactual formation of tetrahydro-β-carbolines and β-carbolines during analysis, but ...
9-Methyl-β-carbolines appear to induce DNA damage when exposed to ultra-violet light. β-Carboline belongs to the group of ... It is also the prototype of a class of compounds known as β-carbolines. β-Carboline alkaloids are widespread in plants and ... Some β-carbolines, notably tryptoline and pinoline, may be formed naturally in the human body. The latter is possibly ... Beta-Carbolines at the US National Library of Medicine Medical Subject Headings (MeSH) TiHKAL #44 TiHKAL in general Beta- ...
beta-Carbolines, harman (1-methyl-9H-pyrido[3,4-b]indole) and norharman (9H-pyrido[3,4-b]indole) and gamma-carbolines, 3-amino- ... Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities.. Funayama Y1, Nishio K, Wakabayashi K, Nagao ...
Carbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of ... Carbolines (Beta-Carbolines). Subscribe to New Research on Carbolines A group of pyrido-indole compounds. Included are any ... 1-hydroxymethyl-tetrahydro-beta-carboline-3-carboxylic acid. *1-methyl-2-nitroso-1,2,3,4-tetrahydo-beta-carboline-3-carboxylic ... 1-hydroxymethyl-tetrahydro-beta-carboline-3-carboxylic acid. *1-methyl-2-nitroso-1,2,3,4-tetrahydo-beta-carboline-3-carboxylic ...
Synthesis and Evaluation of 1-Amino-6-halo-β-carbolines as Antimalarial and Antiprion Agents. ... Synthesis and Evaluation of 1-Amino-6-halo-β-carbolines as Antimalarial and Antiprion Agents. ChemMedChem, 7: 578-586. doi: ...
The results imply that electron-withdrawing groups on N2 of tetrahydro-γ-carbolines and N5-H are necessary. The synthesis of 5 ... 4-tetrahydro-γ-carbolines has been developed, which provides a convenient and efficient method for the synthesis of the ... Keywords: : Winterfeldt oxidation; 1,2,3,4-tetrahydro-γ-carbolines; dihydropyrrolo[3,2-b]-quinolones; pyrrolo[3,2-b]quinolones ... The results imply that electron-withdrawing groups on N2 of tetrahydro-γ-carbolines and N5-H are necessary. The synthesis of 5 ...
It is concluded that the beta-carbolines FG 7142 and DMCM produce selective effects upon LCGU that are mediated by ... For this purpose, beta- carbolines FG 7142 and DMCM were employed. They exert their effects via the benzodiazepine receptor, ... Changes in local cerebral glucose utilization induced by the beta- carbolines FG 7142 and DMCM reveal brain structures involved ... Changes in local cerebral glucose utilization induced by the beta- carbolines FG 7142 and DMCM reveal brain structures involved ...
Beta carboline explanation free. What is Beta carboline? Meaning of Beta carboline medical term. What does Beta carboline mean? ... Looking for online definition of Beta carboline in the Medical Dictionary? ... beta-carboline. (redirected from Beta carboline) β-carboline. (bā-ta-kahrō-lēn), One of a class of indole alkaloids ... Beta carboline , definition of Beta carboline by Medical dictionary https://medical-dictionary.thefreedictionary.com/Beta+ ...
download anxiolytic carbolines from molecular biology to the, by embalming our honorarium imperfect, conveys us private of it; ... download anxiolytic carbolines from TO BOOKS I and II. The Beat The download anxiolytic carbolines from of chestnut is the ... 2019; d of its volcanic download anxiolytic carbolines from molecular biology to the. The download anxiolytic carbolines from ... In my download anxiolytic carbolines from molecular, this earth- is foregoing. Either the download anxiolytic carbolines from ...
A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles i ... The first example of versatile synthesis of functionalized β-carbolines and γ-carbolines via redox-free Pd-catalyzed C-H ... The first example of versatile synthesis of functionalized β-carbolines and γ-carbolines via redox-free Pd-catalyzed C-H ... A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in ...
This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF3 ... 4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. ... Asymmetric synthesis of CF3- and indole-containing tetrahydro-β-carbolines via chiral spirocyclic phosphoric acid-catalyzed aza ... Asymmetric synthesis of CF3- and indole-containing tetrahydro-β-carbolines via chiral spirocyclic phosphoric acid-catalyzed aza ...
In this study, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1), an amino acid isolated from C. endivia. L, was found ...
... Mohammad Movassaghi* and ... The direct conversion of various amides to isoquinoline and β-carboline derivatives via mild electrophilic amide activation, ...
By assaying several β-carboline compounds, we define certain chemical groups that modulate the affinity of this class of ... Results demonstrate that the β-carboline compounds (1) potently reduce the expression of all three phosphorylated forms of tau ... Here we test the ability of harmine, and numerous additional β-carboline compounds, to inhibit the DYRK1A dependent ... a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A ( ...
... ß-Carbolines from marine derived Bacteria , Revista Latinoamericana de Química, 35 , pp. 58-67 . ...
Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. ... tetrahydro-beta-carboline compounds related to the natural product fascaplysin, as novel inhibitors of CDK4/cyclin D1. We show ...
Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys.. J E Barrett, L S Brady, ... Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys.. J E Barrett, L S Brady, ... Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys.. J E Barrett, L S Brady, ... Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys. ...
β-carboline-2-carbo. xamide [ACD/IUPAC Name] N-[2-(1,3-Benzodiox. ol-5-ylamino)-2-oxo. éthyl]-6-chloro-1,3. ,4,9-tétrahydro-2H- ... 9-tetrahydro-2H-β-carboline-2-. carboxamide *Molecular FormulaC21H19ClN4O4 ...
9-dihydro-3H-beta-carboline - chemical structural formula, chemical names, chemical properties, synthesis references ...
Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and ... Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and ... Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and ... Theoretical structure-activity studies of beta-carboline analogs. Requirements for benzodiazepine receptor affinity and ...
On the basis of these studies we suggest that the effect of tetrahydro-beta-carboline-related alkaloids on pituitary hormone ... On the basis of these studies we suggest that the effect of tetrahydro-beta-carboline-related alkaloids on pituitary hormone ... 4-tetrahydro-beta-carboline (6-MeOTHBC) and yohimbine to normal or hypothyroid rats [the latter exhibiting chronically elevated ... 4-tetrahydro-beta-carboline (6-MeOTHBC) and yohimbine to normal or hypothyroid rats [the latter exhibiting chronically elevated ...
Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A) dopamine D2 and benzodiazepine receptors.. Drug and ... β-Carbolines as specific inhibitors of cyclin-Dependent kinases.. Bioorganic & Medicinal Chemistry Letters 12:1129-1132 ... Effects of induction on the metabolism and cytochrome P-450 binding of harman and other β-carbolines.. Xenobiotica 18:785-796 ... Inhibition of monoamine oxidase A by β-carboline derivatives.. Archives of Biochemistry and Biophysics 337:137-142 ...
Toxoplasma gondii β-carbolinesDrugInvasionCell cycle. Findings. The protozoan parasite Toxoplasma gondii is the etiologic agent ... Song Y, Wang J, Teng SF, Kesuma D, Deng Y, Duan J, Wang JH, Qi RZ, Sim MM: β-Carbolines as specific inhibitors of cyclin- ... β-Carbolines (βCs), such as harmane, norharmane and harmine, are a group of naturally occurring alkaloids that show ... Di Giorgio C, Delmas F, Ollivier E, Elias R, Balansard G, Timon-David P: In vitro activity of the beta-carboline alkaloids ...
Grodzki, A., Poola, B., Pasupuleti, N., Nantz, M. H., Lein, P. J., & Gorin, F. A. (2015). A novel carboline derivative inhibits ... b-Carbolines are a large group of natural and synthetic indole alkaloids, some of which block activation of nuclear factor k- ... b-Carbolines are a large group of natural and synthetic indole alkaloids, some of which block activation of nuclear factor k- ... b-Carbolines are a large group of natural and synthetic indole alkaloids, some of which block activation of nuclear factor k- ...
  • As components of the liana Banisteriopsis caapi, the β-carbolines harmine, harmaline, and tetrahydroharmine play a pivotal role in the pharmacology of the indigenous psychedelic drug ayahuasca by preventing the breakdown of dimethyltryptamine in the gut by reversibly inhibiting monoamine oxidase, thus making it psychoactive upon oral administration. (wikipedia.org)
  • Harmine, a β-carboline alkaloid, is a high affinity inhibitor of the dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) protein. (plos.org)
  • Here we test the ability of harmine, and numerous additional β-carboline compounds, to inhibit the DYRK1A dependent phosphorylation of tau protein on serine 396, serine 262/serine 356 (12E8 epitope), and threonine 231 in cell culture assays and in vitro phosphorylation assays. (plos.org)
  • Harmine, a naturally occurring β-carboline alkaloid, has long been used in folk medicine in the Middle East and in Asia ( Sourkes, 1999 ) and as a hallucinogenic drug ( Wink & van Wyk, 2008 ). (peerj.com)
  • By gas chromatography coupled to mass spectrometry, the chemical profile of P. harmala seeds was identified and the β-carbolines (harmaline and harmine) were identified, which are compounds of great pharmacological importance for the species. (academicjournals.org)
  • In addition, we show that one of these beta-carboline analogues inhibits the phosphorylation of IkappaBalpha and subsequent activation of NF-kappaB in whole cells, as well as blocking TNF-alpha release in LPS-challenged mice. (nih.gov)
  • The structure of β-carboline is similar to that of tryptamine, with the ethylamine chain re-connected to the indole ring via an extra carbon atom, to produce a three-ringed structure. (wikipedia.org)
  • Substituted tryptamine Phenethylamine http://www.chemicalbook.com/ProductChemicalPropertiesCB8192006_EN.htm[full citation needed] Jones R.S. (1982). (wikipedia.org)
  • Novel IKK inhibitors: beta-carbolines. (nih.gov)
  • Optimization of this beta-carboline natural product derivative resulted in a novel class of selective IKK inhibitors with IC(50)s in the nanomolar range. (nih.gov)
  • These data demonstrate that relative to other carbolines and pharmacologic inhibitors of NOS, 8-Gly carb exhibits a unique pharmacological profile by inhibiting constitutive and inducible NO formation independent of NF-κB activation and cytokine expression. (elsevier.com)
  • Reversed-phase ion-pair HPLC with fluorimetric detectors connected in series was studied for the simultaneous determination of two tetrahydro-β-carbolines and two β-carbolines. (springer.com)
  • This treatment not only suppressed the artefactual formation of tetrahydro-β-carbolines and β-carbolines during analysis, but also effectively purified them. (springer.com)
  • The quantitative ranges were 0.25-80.0 ng mL −1 for both tetrahydro-β-carbolines and 0.1-30.0 ng mL −1 for both β-carbolines. (springer.com)
  • The results imply that electron-withdrawing groups on N 2 of tetrahydro-γ-carbolines and N 5 -H are necessary. (mdpi.com)
  • This methodology provides a facile route to 1-trifluoromethyl-1-indole-substituted tetrahydro-β-carbolines featuring a CF 3 -containing quaternary stereocenter in considerable yields and good enantioselectivities. (rsc.org)
  • 3S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic Acid from Cichorium endivia. (mdpi.com)
  • 6-Methoxy-l ,2,3,4-tetrahydro-β-carboline (I) has been shown to be found in the brains of animals . (musc.edu)
  • A wide range of functionalized β-carbolines and γ-carbolines can be prepared from readily accessible indoles and nitriles in good to excellent yields under the optimal conditions. (rsc.org)
  • An enantioselective aza-Friedel-Crafts alkylation reaction of indoles with 1-trifluoromethyl-3,4-dihydro-β-carbolines catalyzed by a chiral spirocyclic phosphoric acid has been realized. (rsc.org)
  • Benzo-indoles similar to CARBOLINES which are pyrido-indoles. (bioportfolio.com)
  • Available a mere two weeks after publication of the hard copy, Knowledge Update 2018/2 features a major new chapter on carbolines or pyrido[X,Y-b]indoles by J. A. Joule. (thieme.de)
  • Thus, this novel carboline derivative holds promise as a parent compound, leading to therapeutic agents that prevent the development of neuropathic pain mediated by macrophage-derived NO without interfering with cytokine expression required for neural recovery following peripheral nerve injury. (elsevier.com)
  • Introduction Natural products have a profound impact on both chemical biology and drug discovery, and the substituted β-carboline moiety is an example. (scribd.com)
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  • Similarly, stacking interactions with neutral or cationic aromatic residues such as tryptophan or protonated histidine could occur, but do not appear to be determinants of the relative receptor affinity of the beta-carbolines. (aspetjournals.org)
  • A screening effort of the endogenous IKK complex allowed us to identify 5-bromo-6-methoxy-beta-carboline as a nonspecific IKK inhibitor. (nih.gov)
  • Beta-Carbolines at the US National Library of Medicine Medical Subject Headings (MeSH) TiHKAL #44 TiHKAL in general Beta-carbolines in Coffee Farzin D, Mansouri N (July 2006). (wikipedia.org)
  • beta-Carbolines for Alzheimer's disease? (curehunter.com)
  • For this purpose, beta- carbolines FG 7142 and DMCM were employed. (jneurosci.org)
  • It is concluded that the beta-carbolines FG 7142 and DMCM produce selective effects upon LCGU that are mediated by benzodiazepine receptors. (jneurosci.org)
  • Interactions of zopiclone with ethyl-beta-carboline-3-carboxylate and Ro 15-1788 in squirrel monkeys. (aspetjournals.org)
  • Theoretical structure-activity studies of beta-carboline analogs. (aspetjournals.org)
  • Steve Beyer , author of Singing to the Plants: A Guide to Mestizo Shamanism in the Upper Amazon , questions the Western conventional wisdom that the sole function of the beta-carbolines in the ayahuasca drink is simply to allow DMT to become orally active, and explores the scientific and ethnographic literature for evidence of beta-carboline psychoactivity. (ayahuasca.com)
  • In our previous studies C3-Pyrazole/Chalcone Linked Beta-Carboline Hybrids were synthesized and evaluated for their cytotoxic activity in a panel of five human cancer cell lines and the new molecules like 7d and 8d were considered as potential leads. (iraj.in)
  • As such, the beta-carbolines may also be less addictive. (eurekalert.org)
  • Do beta-carbolines exist in the small root seedlings? (shroomery.org)
  • Alkenyl Isocyanide Conjugate Additions: A Rapid Route to γ-Carbolines" Chepyshev, S. V. (drexel.edu)
  • Different levels of saturation are possible in the third ring, which is indicated here in the structural formula by colouring the optionally double bonds red and blue: Some of the more important β-carbolines are tabulated by structure below. (wikipedia.org)
  • Some β-carbolines, notably tryptoline and pinoline, may be formed naturally in the human body. (wikipedia.org)
  • In this paper, we describe a two-step preparation of 3-substituted β-carbolinones using 3-substituted β-carbolines as the starting materials (Scheme 3). (scribd.com)
  • Penetrating primer/sealer for use on concrete substrates and Carboline Pyrocrete® Fireproofing products. (carboline.com)
  • As a result of the presence of β-carbolines in the cuticle of scorpions, their skin is known to fluoresce when exposed to certain wavelengths of ultraviolet light such as that produced by a blacklight. (wikipedia.org)