Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.
ZAP-70 Protein-Tyrosine Kinase
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
STAT6 Transcription Factor
A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Antigens, Tumor-Associated, Carbohydrate
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Lymphocyte Function-Associated Antigen-1
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Transferrin-Binding Protein B
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Transferrin-Binding Protein A
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Amino Acid Sequence
Gene Expression Regulation
Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
Bacterial Transferrin Receptor Complex
An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.
Electrophoresis, Polyacrylamide Gel
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
Iron Chelating Agents
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Coated Pits, Cell-Membrane
Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393)
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Iron Regulatory Protein 1
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Congenital Disorders of Glycosylation
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Chromatography, High Pressure Liquid
rab4 GTP-Binding Proteins
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Chromatography, Ion Exchange
Magnetic Resonance Spectroscopy
Rats, Inbred Strains
rab GTP-Binding Proteins
Nephelometry and Turbidimetry
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Fusion Proteins, gag-onc
Antimicrobial Cationic Peptides
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Tumor Cells, Cultured
Supporting cells projecting inward from the basement membrane of SEMINIFEROUS TUBULES. They surround and nourish the developing male germ cells and secrete ANDROGEN-BINDING PROTEIN and hormones such as ANTI-MULLERIAN HORMONE. The tight junctions of Sertoli cells with the SPERMATOGONIA and SPERMATOCYTES provide a BLOOD-TESTIS BARRIER.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Lewis Blood-Group System
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Traditional screening tests utilized for congenital disorders of glycosylation, including carbohydrate deficient transferrin ...
As a blood marker PEth is more sensitive than carbohydrate deficient transferrin (CDT), urinary ethyl glucuronide (EtG) and ...
1 High carbohydrate deficient transferrin (CDT) With regard to alcoholism, BAC is useful to judge alcohol tolerance, which in ...
... or CdT may refer to: Carbohydrate deficient transferrin, a transporter protein isoform typically increased in alcoholism ...
Alcohol withdrawal syndrome
... testing for elevated values of carbohydrate-deficient transferrin or gammaglutamyl transferase can help make the diagnosis of ... Individuals who have an alcohol use disorder are often deficient in various nutrients, which can cause severe complications ... and pyridoxine intravenously is recommended before starting any carbohydrate-containing fluids or food. These vitamins are ...
Optimization of conditions in view of its application to the HPLC analysis of carbohydrate-deficient transferrin (CDT)". ... Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2). ... Transferrin bound to its receptor. Transferrin receptor complex. Transferrin is also associated with the innate immune system. ... Carbohydrate deficient transferrin increases in the blood with heavy ethanol consumption and can be monitored through ...
Carbohydrate deficient transferrin
These are referred to as carbohydrate-deficient transferrins. These carbohydrate-deficient transferrins can be measured in the ... Carbohydrate-deficient transferrin is elevated in the blood of people with heavy alcohol consumption but elevated levels can ... Carbohydrate-deficient transferrin (CDT, also known as desialotransferrin or asialotransferrin) is a laboratory test used to ... carbohydrate-deficient transferrin can be a useful tool in identifying problem drinking, such as alcohol use disorder. However ...
Carbohydrate deficient transferrin. *Cardiac marker. *Ceruloplasmin. *Chromatography. *Creatine kinase. *N-terminal telopeptide ...
Høyt karbohydratfattig transferrin (carbohydrate-deficient transferrin -CDT). Ingen av disse blodprøvene for biologiske ...
Congenital disorder of glycosylation
Körner C, Knauer R, Holzbach U, Hanefeld F, Lehle L, von Figura K (1998). "Carbohydrate-deficient glycoprotein syndrome type V ... The most commonly used screening method for CDG, analysis of transferrin glycosylation status by isoelectric focusing, ESI-MS, ... Jaeken J, Schachter H, Carchon H, De Cock P, Coddeville B, Spik G (1994). "Carbohydrate deficient glycoprotein syndrome type II ... GeneReviews/NIH/NCBI/UW entry on PMM2-CDG (CDG-Ia)Carbohydrate-Deficient Glycoprotein Syndrome, Type 1a; Congenital Disorder of ...
possibly involving the transferrin receptor. IGFBP-3 enters the cell nucleus by a mechanism that is incompletely understood, ... serum IGFBP-3 is increased in acromegaly and low in GH-deficient children. However, IGFBP-3 gene expression in human liver is ... owing to the occupancy of either two or three of its N-glycosylation sites by carbohydrate. Hypoglycosylated IGFBP-3 may be ... Storch S, Kübler B, Höning S, Ackmann M, Zapf J, Blum W, Braulke T (2001). "Transferrin binds insulin-like growth factors and ...
In accordance, genome analysis of Prevotella copri showed it was deficient in the ability to degrade host glycans and is more ... while for those who consume more carbohydrates, especially fibre, the Prevotella species dominate. However, Prevotella has ... Inorganic iron and iron-binding proteins such as transferrin and lactoferrin do not support the growth of P. intermedia, ...
Surfactant protein D
October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of ... "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and ... inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice ... October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of ...
In blood plasma, zinc is bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because ... Nearly two billion people in the developing world are deficient in zinc. In children, it causes an increase in infection ... defects in carbohydrate utilization, and reproductive teratogenesis. Mild zinc deficiency depresses immunity, ... Zinc-deficient soil is cultivated in the cropland of about half of Turkey and India, a third of China, and most of Western ...
... and transferrin (10%). Because transferrin also transports iron, excessive iron reduces zinc absorption, and vice versa. A ... Zinc-deficient soil is cultivated in the cropland of about half of Turkey and India, a third of China, and most of Western ... defects in carbohydrate utilization, and reproductive teratogenesis. Zinc deficiency depresses immunity, but excessive zinc ... Plants that grow in soils that are zinc-deficient are more susceptible to disease. Zinc is added to the soil primarily through ...
Surfactant protein A1
... and a carbohydrate recognition domain. The C-terminal carbohydrate recognition domain (CRD) allows binding to various types of ... a lung disease characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich ... "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and ... SP-A1 binds to the carbohydrates found in the surface of several microorganisms and helps in the defense against respiratory ...
Blood plasma as a result carries iron tightly bound to transferrin, which is taken up by cells by endocytosing transferrin, ... carbohydrate, low-fat diets, may be at an increased risk for iron deficiency. ... or iron-deficient erythropoiesis (IDE). ... iron is carried tightly bound to the protein transferrin. There ...
Carbohydrate deficient transferrin - Wikipedia
These are referred to as carbohydrate-deficient transferrins. These carbohydrate-deficient transferrins can be measured in the ... Carbohydrate-deficient transferrin is elevated in the blood of people with heavy alcohol consumption but elevated levels can ... Carbohydrate-deficient transferrin (CDT, also known as desialotransferrin or asialotransferrin) is a laboratory test used to ... carbohydrate-deficient transferrin can be a useful tool in identifying problem drinking, such as alcohol use disorder. However ...
Gamma-carbohydrate-deficient transferrin definition | Drugs.com
Definition of gamma-carbohydrate-deficient transferrin. Provided by Stedmans medical dictionary and Drugs.com. Includes ... gamma-carbohydrate-deficient transferrin. Definition: a calculated laboratory value, the sum of carbohydrate-deficient ... transferrin and gamma-glutamyltransferase that is useful in assessing long-term ethanol exposure. ...
carbohydrate-deficient transferrin | Taber's Medical Dictionary
carbohydrate-deficient transferrin answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available ... transferrin. Carbohydrate-deficient transferrin. In: Venes D, ed. Tabers Medical Dictionary. 23rd ed. F.A. Davis Company; 2017 ... transferrin. Carbohydrate-deficient Transferrin [Internet]. In: Venes D, editors. Tabers Medical Dictionary. F.A. Davis ... transferrin. Accessed December 6, 2019.. Carbohydrate-deficient transferrin. (2017). In Venes, D. (Ed.), Tabers Medical ...
Serum carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with chronic liver diseases
We measured serum levels of carbohydrate deficient transferrin (CDT) in 420 subjects: 100 healthy blood donors, 82 healthy ... Serum carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with chronic liver diseases Alcohol ... We measured serum levels of carbohydrate deficient transferrin (CDT) in 420 subjects: 100 healthy blood donors, 82 healthy ... No advantage was gained by using the CDT/transferrin ratio. Our study confirms that CDT is a specific marker for chronic ...
Determination of Serum Carbohydrate-Deficient Transferrin (CDT) by the Nephelometric N Latex CDT Assay in Japanese Habitual...
1997) Is carbohydrate-deficient transferrin a specific marker for alcohol abuse? A study in patients with chronic viral ... Carbohydrate Deficient Transferrin (CDT) is now widely used for detection of chronic alcohol abuse and monitoring sobriety in ... 2001) Carbohydrate deficient transferrin in abstaining patients with end-stage liver disease. Alcohol Clin Exp Res 25: 1729- ... Determination of Serum Carbohydrate-Deficient Transferrin (CDT) by the Nephelometric N Latex CDT Assay in Japanese Habitual ...
Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from...
Carbohydrate-Deficient Transferrin (CDT) during 2 to 3 weeks of Alcohol Misuse in Men and Women and its Significance in View...
According to many researchers, carbohydrate-deficient transferrin (CDT) - an abnormal transferrin characterized by lowered ... Carbohydrate-Deficient Transferrin (CDT) during 2 to 3 weeks of Alcohol Misuse in Men and Women and its Significance in View of ... Stibler H: Carbohydrate-deficient transferrin in serum: a new marker of potentially harmful alcohol consumption reviewed. Clin ... Bell H, Tallaksen C, Sjahem T, Weberg R et al: Serum carbohydrate-deficient transferrin as a marker of alcohol consumption in ...
Anion-exchange chromatography versus isoelectric focusing of transferrin in diagnosing the carbohydrate-deficient glycoprotein...
Carbohydrate‐deficient transferrin in alcoholics with liver disease<...
... deficient transferrin (CDT) and alcoholic liver disease, we measured the ratio of carbohydrate‐deficient transferrin to total ... deficient transferrin (CDT) and alcoholic liver disease, we measured the ratio of carbohydrate‐deficient transferrin to total ... deficient transferrin (CDT) and alcoholic liver disease, we measured the ratio of carbohydrate‐deficient transferrin to total ... deficient transferrin (CDT) and alcoholic liver disease, we measured the ratio of carbohydrate‐deficient transferrin to total ...
Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and...
Background: Carbohydrate-deficient transferrin (CDT) is used for diagnosis of chronic alcohol abuse. Some 200-300 reports on ... Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and ... Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and ... Carbohydrate-deficient Transferrin as a Marker of Chronic Alcohol Abuse: A Critical Review of Preanalysis, Analysis, and ...
Carbohydrate Deficient Transferrin | Nicklaus Children's Hospital
Therefore, a blood test of carbohydrate deficient transferrin is frequently used to diagnose one type of disorder of ... Carbohydrate deficient transferrin is a substance in the blood that become altered in congenital disorders of glycosylation. ... What is carbohydrate deficient transferrin? Carbohydrate deficient transferrin is a substance in the blood that become altered ... A routine blood draw is required in order to perform the carbohydrate deficient transferrin test. The blood sample is then ...
SYNLAB En: CDT (CARBOHYDRATE DEFICIENT TRANSFERRIN), SERUM
Carbohydrate Deficient Transferrin (CDT) | Private Blood Tests
The protein transferrin carries iron to parts of the body, heavy consumption of alcohol can increase transferrin. High CDT ... Included in each test request for Carbohydrate Deficient Transferrin are a Doctors Referral, all Phlebotomy fees (your blood ... This private blood analysis for Carbohydrate Deficient Transferrin is accessible at all thirty one private outpatient ... CDT blood testing can be used to screen for alcohol abuse (heavy alcohol consumption). The protein transferrin carries iron to ...
Carbohydrate Deficient Transferrin (CDT) Test - Orbit Labs
Carbohydrate Deficient Transferrin (CDT) Test. Home , Carbohydrate Deficient Transferrin (CDT) Test The Carbohydrate Deficient ... The effect is a change in the number of carbohydrate molecules within the protein. The level of deficiency is reported as a ... Transferrin (CDT) blood test provided by Orbit Labs looks at transferrin, a protein that transports iron around the body, which ...
Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation | MLabs
Transferrin Mono-oligo/Di-oligo Ratio: ,or= 0.06; Transferrin A-oligo/Di-oligo Ratio: ,or= 0.011; Transferrin Tri-sialo/Di- ... and liver disease may result in increased levels of carbohydrate deficient transferrin. Relevant clinical information and the ... Mono-oligosaccharide/Di-oligosaccharide transferrin ratio. A-oligosaccharide/Di-oligosaccharide transferrin ratio ...
Carbohydrate Deficient Transferrin (CDT) Blood Test | Blood Tests in London
Carbohydrate-Deficient Transferring (CDT) is a laboratory test used to help detect heavy ethanol consumption in patients with ... Target Turn Around Time in working days: This private blood test for Carbohydrate Deficient Transferrin (CDT) in London has a ... This private blood test for Carbohydrate Deficient Transferrin (CDT) in London has a guaranteed turnaround time of 4 working ... days and tests for Carbohydrate Deficient Transferrin (CDT) only. Turnaround Time Order Online Now. A GP Referral is Included. ...
Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation (CDG) | ARUP Lab Test Directory
CDG (Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation). *CDGS (Carbohydrate Deficient Transferrin ... Carbohydrate Deficient Transferrin for Congenital Disorders o. *Glycoprotein Syndrome (Carbohydrate Deficient Transferrin for ... Carbohydrate Deficient Glycoprotein Syndrome (Carbohydrate Deficient Transferrin for Congenital Diso. * ... CDT (Carbohydrate Deficient Transferrin for Congenital Disorders of Glycosylation). *Congenital Disorders of Glycosylation ( ...
Browsing Faculty of Natural and Agricultural Sciences by Subject "Percentage carbohydrate-deficient transferrin"
Biomarkers of Heavy Drinking
Carbohydrate-Deficient Transferrin. Transferrin, a negatively charged glycoprotein, is metabolized in the liver, circulates in ... With heavy alcohol intake, these moieties can lose carbohydrate content, hence the term "carbohydrate-deficient" transferrin ( ... Carbohydrate-deficient transferrin. 2-4 weeks of abstinence. 60+ g/d for at least 2 weeks. Rare false positives. Good indicator ... Stibler, H. Carbohydrate-deficient transferrin in serum: A new marker of potentially harmful alcohol consumption reviewed. Clin ...
Usefulness of carbohydrate-deficient transferrin and trypsin activity in the diagnosis of acute alcoholic pancreatitis.
Forensic aspects of postmortem serum carbohydrate-deficient transferrin analysis as a marker of alcohol abuse
Carbohydrate-deficient transferrin (CDT) has been suggested as one of alcohol abuse indicators having produced good results in ... carbohydrate-deficient transferrin - CDT) jedan je od markera zloupotrebe alkohola koji je pokazao najbolje rezultate u sudskoj ... Forensic aspects of postmortem serum carbohydrate-deficient transferrin analysis as a marker of alcohol abuse. Forenzički ... alcoholism / carbohydrate-deficient transferrin (CDT) / postmortem analysis / specificity / sensitivity / alkoholizam / ...
Forensic Aspects of Postmortem Serum Carbohydrate-Deficient Transferrin Analysis as a Marker of Alcohol Abuse
alcoholism / carbohydrate-deficient transferrin (CDT) / carbohydrate-deficient transferrin (CDT) / postmortem analysis / ... carbohydrate-deficient transferrin - CDT) jedan je od markera zloupotrebe alkohola koji je pokazao najbolje rezultate u sudskoj ... Introduction Carbohydrate-deficient transferrin (CDT) has been suggested as one of alcohol abuse indicators having produced ... Forensic Aspects of Postmortem Serum Carbohydrate-Deficient Transferrin Analysis as a Marker of Alcohol Abuse. Forenzički ...
2018 Publications of Interest - IFCC
Alcohol Use Biomarkers | ARUPConsult Lab Test Selection
Carbohydrate Deficient Transferrin for Alcohol Use 0070412. PEth. 1-2 wks or longer (blood). ≥20 ng/mL. Phosphatidylethanol ( ... Carbohydrate-Deficient Transferrin. CDT, an indirect metabolite of ethanol, is a serum marker of long-term, heavy alcohol use ... Combining serum carbohydrate-deficient transferrin and hair ethyl glucuronide to provide optimal information on alcohol use. ... Carbohydrate-deficient transferrin (CDT) and phosphatidylethanol (PEth) are useful markers for monitoring abstinence following ...
Alcohol Use Biomarkers Testing | Test Fact Sheet
Carbohydrate deficient transferrin (CDT). *Negative charged glycoprotein proteins with incomplete glycan chain(s) *Markedly ... Carbohydrate Deficient Transferrin. *Cannot be used in individuals suspected of having congenital glycosylation disorders. ... Alcohol use biomarkers (eg, ethyl glucuronide, ethyl sulfate, carbohydrate deficient transferrin) can help determine acute or ...
Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease<...
Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease. Mayo Clinic ... Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease. / Stadheim, Linda ... Value of determining carbohydrate-deficient transferrin isoforms in the diagnosis of alcoholic liver disease. ... Objective: To determine whether isoform separation of carbohydrate-deficient transferrin (CDT) is of value in the diagnosis of ...
Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population...
A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels -...
Chromatographic Methods in Clinical Chemistry and Toxicology | Pharmaceutical & Medicinal Chemistry | Chemistry | Subjects |...
Treatment of Alcohol Dependence and Comorbid Bipolar Disorder - Full Text View - ClinicalTrials.gov
Congenital disorders ofGlycoproteinSerum transferrinBiomarkersGamma-glutamyltransferaseSialic acidIsoelectricAspartate aminotransferaseMonitoring abstinenceQuantificationIsoformsTotal transferrinCapillary zone electrophoGlycoformsEthanolVariants2001HumansIsoformMicroheterogeneityHPLCGeneticBiologicalRatioUsefulnessDetectionPhosphatidylethanolTestMoleculePatientsDisorderPolypeptideAlcohol consumptionBloodProteinsLevelsGlycoproteinsDefinitionChronic alcoholChromatographyAffinityIronInflammationTransferase
Congenital disorders of2
- Carbohydrate deficient transferrin is a substance in the blood that become altered in congenital disorders of glycosylation. (nicklauschildrens.org)
- 6. Chromatographic Measurement of Transferrin Glycoforms for Detecting Alcohol Abuse and Congenital Disorders of Glycosylation (Anders Helander). (wiley.com)
- Only a few serious nonalcohol-related liver diseases like primary biliary cirrhosis, chronic active hepatitis, severly decompensated liver cirrhosis and advanced cirrhosis with ascites may elevate CDT, as well as rare cases of atypical transferrin variants and an inherited disorder - carbohydrate deficient glycoprotein syndrome or CDG (Stiebler 1991, Heyne and Weidinger 1992, Allen et al 1994). (druglibrary.org)
- Transferrin is a glycoprotein with a molecular weight of 75,000 to 80,000, the function of which is to transport iron. (medindia.net)
- Four types of carbohydrate-deficient glycoprotein syndrome have been described, and the cause of two of them has been found. (bmj.com)
- 1 Four types of carbohydrate-deficient glycoprotein syndrome have been recognised, depending on the isoelectric focusing pattern of serum sialotransferrins. (bmj.com)
- Although a heterogenous group of disorders many of the clinical findings of the carbohydrate-deficient glycoprotein syndromes are characteristic, the presentation varies with age and type. (bmj.com)
- The commonest variety of the carbohydrate-deficient glycoprotein syndromes is type Ia, and in most instances a deficiency of phosphomannomutase has been recognised. (bmj.com)
- They also found 11 different missense mutations in the PMM2 gene in 16 patients suffering from the carbohydrate-deficient glycoprotein type Ia syndrome. (bmj.com)
- Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein. (wikipedia.org)
- The review is divided into sections based on microheterogeneity of human serum transferrin (Tf), definition of CDT, structure of human serum CDT, pathomechanisms of ethanol-induced CDT increase, preanalysis, analysis, and medical interpretation (postanalysis). (aaccjnls.org)
- Then biochemical tests can be carried out, especially chromatographic carbohydrate-deficient transferrin assay and isoelectric focusing of serum transferrin. (bmj.com)
- they present as a severe encephalopathy with intractable epilepsy and a different cathodal shift on serum transferrin isoelectric focusing from type Ia. (bmj.com)
- Medical professionals may check serum transferrin level in iron deficiency and in iron overload disorders such as hemochromatosis. (wikipedia.org)
- Alcohol use biomarkers (eg, ethyl glucuronide, ethyl sulfate, carbohydrate deficient transferrin) can help determine acute or chronic alcohol use. (arupconsult.com)
- a calculated laboratory value, the sum of carbohydrate-deficient transferrin and gamma-glutamyltransferase that is useful in assessing long-term ethanol exposure. (drugs.com)
- The purpose of this article is to evaluate the biological marker of heavy alcohol use, carbohydrate-deficient transferrin (CDT), in contrast to the older and more widely used gamma-glutamyltransferase (GGT) for the detection and monitoring of heavy alcohol use. (nih.gov)
- Sialic acid is a monosaccharide carbohydrate. (wikipedia.org)
- In persons who consume significant quantities of alcohol (usually more than 4 or 5 alcoholic beverages a day for two weeks or more), the proportion of transferrin with zero, one, or two sialic acid chains is increased. (wikipedia.org)
- According to many researchers, carbohydrate-deficient transferrin (CDT) - an abnormal transferrin characterized by lowered concentrations of mainly sialic acid resp. (druglibrary.org)
- These include certain alcohol byproducts, such as acetaldehyde, ethyl glucuronide (EtG), and fatty acid ethyl esters (FAEE), as well as two measures of sialic acid, a carbohydrate that appears to be altered in alcoholics. (nih.gov)
- Recently, sialic acid and carbohydrate-deficient transferrin levels have been touted as possible tests, but the sensitivities of both appear to be too low to be useful. (medscape.com)
- Transferrin isoforms were quantified by densitometry of Coomassie-stained transferrins after affinity purification and isoelectric focusing. (elsevier.com)
- The paper describes a study of 58 consecutive male soldiers under 30 years old admitted to an alcohol treatment unit in London, and 51 age- and gender-matched controls to compare the efficacy of isoelectric focusing, a non-quantitative measure of carbohydrate deficient transferrin (CDT), with other markers of alcohol misuse. (cf.ac.uk)
- Used with other tests, such as gamma glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), carbohydrate-deficient transferrin can be a useful tool in identifying problem drinking, such as alcohol use disorder. (wikipedia.org)
- Indirect markers (mean corpuscular volume,γ-glutamyl transferase, alanine aminotransferase and aspartate aminotransferase, and carbohydrate-deficient transferrin) are biological parameters that are influenced by a steady and significant alcohol intake. (dovepress.com)
- Carbohydrate-deficient transferrin (CDT) and phosphatidylethanol (PEth) are useful markers for monitoring abstinence following long-term use. (arupconsult.com)
- Carbohydrate-deficient transferrin (CDT) 1 is considered the most accurate biomarker for identifying sustained heavy alcohol consumption and for monitoring abstinence ( 3 )( 4 ). (aaccjnls.org)
- Detection and Quantification of Carbohydrate-Deficient Transferrin by MALDI-Compatible Protein Chips Prepared by Ambient Ion Soft Landing. (nih.gov)
- Here we demonstrate the ability to quickly resolve isoforms of three model proteins (bovine serum albumin, transferrin, α 1 -antitrypsin) in capillaries coated with novel dynamic coatings. (wiley.com)
- Isoforms of transferrin and α 1 -antitrypsin have been implicated in several human diseases. (wiley.com)
- N Latex CDT uses a monoclonal antibody that recognizes the structure of transferrin glycoforms lacking 1 or 2 complete N-glycans [i.e., disialo-, monosialo-, and asialotransferrins (CDT glycoforms)] in combination with a simultaneous assay for total transferrin. (aaccjnls.org)
- The Dade Behring BN II™ and BN ProSpec® systems automatically calculate the CDT value as a percentage of total transferrin (%CDT). (aaccjnls.org)
Capillary zone electropho1
- Fast determination of carbohydrate deficient transferrin using capillary zone electrophoresis. (ugent.be)
- Amino acid sequence variation is observed in individuals with genetic variants B, C, and D ( 8 ), whereas transferrin glycoforms with variable carbohydrate content and/or branching of the maximum 2 N-linked oligosaccharide chains (N-glycans) are always present ( 4 )( 7 )( 9 ). (aaccjnls.org)
- Carbohydrate-deficient transferrin (CDT, also known as desialotransferrin or asialotransferrin) is a laboratory test used to help detect heavy ethanol consumption. (wikipedia.org)
- Carbohydrate-Deficient Transferring (CDT) is a laboratory test used to help detect heavy ethanol consumption in patients with unexplained elevations of MCV, liver enzymes, HDL or idiopathic neuropathies. (bloodtestslondon.com)
- Transferrin genetic variants did not interfere with measurements. (aaccjnls.org)
- The specificity of N Latex CDT for identifying alcohol abuse may be higher than for immunoassays that use column separation, because transferrin genetic variants do not interfere with measurements. (aaccjnls.org)
- Drawbacks with this last approach are the labor involved and the fact that transferrin genetic variants may cause falsely high or falsely low results ( 28 ). (aaccjnls.org)
- Anton RF (2001) Carbohydrate-deficient transferrin for detection and monitoring of sustained heavy drinking. (springer.com)
- The gene coding for transferrin in humans is located in chromosome band 3q21. (wikipedia.org)
- In humans, transferrin consists of a polypeptide chain containing 679 amino acids and two carbohydrate chains. (wikipedia.org)
- Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2). (wikipedia.org)
- Objective: To determine whether isoform separation of carbohydrate-deficient transferrin (CDT) is of value in the diagnosis of alcoholic liver disease (ALD) and is specific to ALD when compared with other liver diseases. (elsevier.com)
- 6.2 Transferrin Microheterogeneity. (wiley.com)
- 6.5 Analytical Methods for Transferrin Microheterogeneity. (wiley.com)
- Transferrin, which occurs at concentrations of 2.0-3.5 g/L in serum, exhibits a degree of microheterogeneity that depends on iron saturation (∼30%), amino acid sequence, and/or carbohydrate content ( 5 )( 6 )( 7 ). (aaccjnls.org)
- Moreover, modified sequences are frequently also present unmodified (heterogeneity), and when occupied, the same site may be modified with different carbohydrate structures (microheterogeneity). (mcponline.org)
- The HPLC method did not allow for baseline separation between disialo- and disialotransferrin in serum containing a rare genetic transferrin variant, tentatively identified as C2C3 (3, 32). (thefreedictionary.com)
- An absence of transferrin results from a rare genetic disorder known as atransferrinemia, a condition characterized by anemia and hemosiderosis in the heart and liver that leads to heart failure and many other complications. (wikipedia.org)
- Transferrins are glycoproteins that are often found in biological fluids of vertebrates. (wikipedia.org)
- No advantage was gained by using the CDT/transferrin ratio. (nih.gov)
- Carbohydrate Deficient Transferrin (CDT) is now widely used for detection of chronic alcohol abuse and monitoring sobriety in alcoholics. (omicsonline.org)
- Specific markers for chronic alcohol use are carbohydrate-deficient transferrin (CDT) and phosphatidylethanol (PEth). (arupconsult.com)
- Therefore, a blood test of carbohydrate deficient transferrin is frequently used to diagnose one type of disorder of glycosylation. (nicklauschildrens.org)
- A routine blood draw is required in order to perform the carbohydrate deficient transferrin test. (nicklauschildrens.org)
- Included in each test request for Carbohydrate Deficient Transferrin are a Doctors Referral, all Phlebotomy fees (your blood taken at a Private Hospital), all laboratory fees and includes our GP comments. (privatebloodtests.co.uk)
- The Carbohydrate Deficient Transferrin (CDT) blood test provided by Orbit Labs looks at transferrin, a protein that transports iron around the body, which is affected by excessive alcohol consumption. (orbitlabs.net)
- This private blood test for Carbohydrate Deficient Transferrin (CDT) in London has a guaranteed turnaround time of 4 working days and tests for Carbohydrate Deficient Transferrin (CDT) only. (bloodtestslondon.com)
- This test measures the level of Carbohydrate-deficient Transferrin (CDT) in the blood. (healthtestingcenters.com)
- E. The serum carbohydrate-deficient transferrin (CDT) level is a useful test for detecting alcohol misuse. (aafp.org)
- It is unclear whether the mechanism is attributable to decreased activity of the glycosyltransferases, which add the carbohydrate groups initially to the transferrin molecule, or to an increased activity of the deglycosylating enzymes for example, sialidase which remove the carbohydrate groups. (medindia.net)
- This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate -deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence . (bvsalud.org)
- An increased plasma transferrin level is often seen in patients suffering from iron deficiency anemia, during pregnancy, and with the use of oral contraceptives, reflecting an increase in transferrin protein expression. (wikipedia.org)
- These carbohydrate-deficient transferrins can be measured in the bloodstream, and are important markers for alcohol use disorder. (wikipedia.org)
- Structurally, transferrin is a polypeptide with two N-linked polysaccharide chains. (wikipedia.org)
- Carbohydrate-deficient transferrin is elevated in the blood of people with heavy alcohol consumption but elevated levels can also be found in a number of medical conditions. (wikipedia.org)
- Carbohydrate Deficient Transferrin (CDT) - Looks at specific protein which can become elevated because of heavy alcohol consumption. (randox.com)
- Transferrin is a serum protein that carries iron through the bloodstream to the bone marrow, where red blood cells are manufactured, as well as to the liver and spleen. (wikipedia.org)
- This private blood analysis for Carbohydrate Deficient Transferrin is accessible at all thirty one private outpatient departments around the UK. (privatebloodtests.co.uk)
- It has been known since 1976 that pathological carbohydrate-deficient fraction of transferrin (CDT) occurs in blood plasma of people who are used to consuming more than 60 g of alcohol daily during 14 days, and disappears again after abstinence. (biomedcentral.com)
- Carbohydrate-deficient transferrin evaluation in dry blood spots. (nih.gov)
- Transferrins are glycoproteins found in vertebrates which bind to and consequently mediate the transport of Iron (Fe) through blood plasma. (wikipedia.org)
- The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all tissues. (wikipedia.org)
- Some invertebrates have proteins that act like transferrin found in the hemolymph. (wikipedia.org)
- Various forms of transferrin exist, with differing levels of sialylation. (wikipedia.org)
- Other conditions such as hereditary fructose intolerance, galactosemia, and liver disease may result in increased levels of carbohydrate deficient transferrin. (umich.edu)
- When plasma transferrin levels rise, there is a reciprocal decrease in percent transferrin iron saturation, and a corresponding increase in total iron binding capacity in iron deficient states A decreased plasma transferrin can occur in iron overload diseases and protein malnutrition. (wikipedia.org)
- Various biochemical markers are then assessed based on this "hematologic" definition of iron-deficient states. (thefreedictionary.com)
- Carbohydrate-deficient transferrin (CDT) is used for diagnosis of chronic alcohol abuse. (aaccjnls.org)
- Transferrin and CDT were measured by isocratic anion exchange chromatography and a radio‐immunoassay. (elsevier.com)
- Transferrin has a molecular weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites. (wikipedia.org)
- The affinity of transferrin for Fe(III) is extremely high (association constant is 1020 M−1 at pH 7.4) but decreases progressively with decreasing pH below neutrality. (wikipedia.org)
- The protein transferrin carries iron to parts of the body, heavy consumption of alcohol can increase transferrin. (privatebloodtests.co.uk)
- Transferrin polymorphism influences iron status in blacks. (ugent.be)
- Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h). (wikipedia.org)
- Transferrins are not limited to only binding to iron but also to different metal ions. (wikipedia.org)
- When not bound to iron, transferrin is known as "apotransferrin" (see also apoprotein). (wikipedia.org)
- When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, e.g., erythroid precursors in the bone marrow, it binds to it and is transported into the cell in a vesicle by receptor-mediated endocytosis. (wikipedia.org)
- The pH of the vesicle is reduced by hydrogen ion pumps (H+ ATPases) to about 5.5, causing transferrin to release its iron ions. (wikipedia.org)
- The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. (wikipedia.org)
- It enables ligand bonding to the transferrin, as each monomer can bind to one or two atoms of iron. (wikipedia.org)
- A hematologic "gold standard" for iron-deficient states? (thefreedictionary.com)
- The level of transferrin decreases in inflammation. (wikipedia.org)
- Relationship between carbohydrate-deficient transferrin, gamma-glutamyl transferase, and mean corpus. (biomedsearch.com)