Organic compounds that contain the -NCO radical.
A group of elements that include SCANDIUM; YTTRIUM; and the LANTHANOID SERIES ELEMENTS. Historically, the rare earth metals got their name from the fact that they were never found in their pure elemental form, but as an oxide. In addition they were very difficult to purify. They are not truly rare and comprise about 25% of the metals in the earth's crust.
Organic salts of cyanic acid containing the -OCN radical.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The pressure due to the weight of fluid.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Inorganic compounds that contain tin as an integral part of the molecule.
A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.
Carbodiimide cross-linking reagent.
Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).
Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Proteins prepared by recombinant DNA technology.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Those individuals engaged in research.
Financial support of research activities.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
A carbodiimide that is used as a chemical intermediate and coupling agent in peptide synthesis. (From Hawley's Condensed Chemical Dictionary, 12th ed)
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet-tasting compounds that are used as chemical intermediates and plant growth stimulants.
An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of NADP. EC 1.18.1.2 was formerly listed as EC 1.6.7.1 and EC 1.6.99.4.
The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)
Cements that act through infiltration and polymerization within the dentinal matrix and are used for dental restoration. They can be adhesive resins themselves, adhesion-promoting monomers, or polymerization initiators that act in concert with other agents to form a dentin-bonding system.
An adhesion procedure for orthodontic attachments, such as plastic DENTAL CROWNS. This process usually includes the application of an adhesive material (DENTAL CEMENTS) and letting it harden in-place by light or chemical curing.
The property of dentin that permits passage of light, heat, cold, and chemical substances. It does not include penetration by microorganisms.
A plant genus in the family FABACEAE known for LATHYRISM poisoning.
Organic compounds that contain silicon as an integral part of the molecule.
Therapy using oral or topical photosensitizing agents with subsequent exposure to light.
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].

Hairpin-shaped DNA duplexes with disulfide bonds in sugar-phosphate backbone as potential DNA reagents for crosslinking with proteins. (1/267)

Convenient approaches were described to incorporate -OP(=O)O(-)-SS-O(-)(O=)PO- bridges in hairpin-shaped DNA duplexes instead of regular phosphodiester linkages: (i) H2O2- or 2,2'-dipyridyldisulfide-mediated coupling of 3'- and 5'-thiophosphorylated oligonucleotides on complementary template and (ii) more selective template-guided autoligation of a preactivated oligonucleotide derivative with an oligomer carrying a terminal thiophosphoryl group. Dithiothreitol was found to cleave completely modified internucleotide linkage releasing starting oligonucleotides. The presence of complementary template as an intrinsic element of the molecule protects the hairpin DNA analog from spontaneous exchange of disulfide-linked oligomer fragments and makes it a good candidate for auto-crosslinking with cysteine-containing proteins.  (+info)

The effect of carboxyl group modification on the chromophore regeneration of archaeopsin-1 and bacterioopsin. (2/267)

Carboxyl group modification with DCCD and NCD-4 was employed to investigate the chemical environment of the side chains of archaeopsin-1 (aO-1) and bacterioopsin (bO). Some differences were observed between aO-1 and bO. Although DCCD or NCD-4 did not modify aO-1 in bleached membrane, they modified bO in bleached membrane and in mixed DMPC/CHAPS/SDS micelles at neutral pH, thereby affecting the opsin shift and the photocycle of the regenerated chromophore. On the contrary, after solubilization with SDS, aO-1 and bO were modified by DCCD and NCD-4, which decreased the chromophore regeneration. In particular, the reaction of aO-1 in SDS with NCD-4 proceeded in a 1:1 ratio at neutral pH. The fluorescence and CD spectra indicated that the modified site was located in the hydrophobic, asymmetrical region. Lysyl-endopeptidase digestion of NCD-4 modified aO-1 produced a fluorescent fragment and amino acid sequence analysis showed that Asp85 or Asp96 in helix C is a probable candidate for the modified residue at present. Kinetic CD measurements revealed that the introduction of N-acylurea at an Asp residue in helix C did not affect the formation of the transient intermediate but inhibited the side chain packing during refolding.  (+info)

Active site characterization of RNase Rs from Rhizopus stolonifer: involvement of histidine and lysine in catalysis and carboxylate in substrate binding. (3/267)

Chemical modification studies on purified RNase Rs revealed the involvement of a single histidine, lysine and carboxylate residue in the catalytic activity of the enzyme. RNA could not protect the enzyme against DEP- and TNBS-mediated inactivation whereas, substrate protection was observed in case of EDAC-mediated inactivation of the enzyme. K(m) and k(cat) values of the partially inactivated enzyme samples suggested that while histidine and lysine are involved in catalysis, carboxylate is involved in substrate binding. Active site nature of RNase Rs suggests that the inability of the enzyme to readily convert 2',3'-cyclic nucleotides to 3'-mononucleotides is probably due to the absence of catalytically active second histidine residue.  (+info)

Structural and kinetic studies of the pyruvate-ferredoxin oxidoreductase/ferredoxin complex from Desulfovibrio africanus. (4/267)

The pyruvate-ferredoxin oxidoreductase (PFOR)/ferredoxin (Fd) system of Desulfovibrio africanus has been investigated with the aim of understanding more fully protein-protein interaction and the kinetic characteristics of electron transfer between the two redox partners. D. africanus contains three Fds (Fd I, Fd II and Fd III) able to function as electron acceptors for PFOR. The complete amino acid sequence of Fd II was determined by automatic Edman degradation. It revealed a striking similarity to that of Fd I. The protein consists of 64 residues and its amino acid sequence is in agreement with a molecular mass of 6822.5 Da as measured by electrospray MS. Fd II contains five cysteine residues of which the first four (Cys11, Cys14, Cys17 and Cys54) are likely ligands for the single [4Fe-4S] cluster. A covalently cross-linked complex between PFOR and Fd I or Fd II was obtained by using a water soluble carbodiimide. This complex exhibited a stoichiometry of one ferredoxin for one PFOR subunit and is dependent on the ionic strength. The second-order rate constants for electron transfer between PFOR and Fds determined electrochemically using cyclic voltammetry are 7 x 107 M-1.s-1 for Fd I and 2 x 107 M-1.s-1 for Fd II and Fd III. The Km values of PFOR for Fd I and Fd II measured both by the electrochemical and the spectrophotometric method have been found to be 3 microM and 5 microM, respectively. The three-dimensional modelling of Fd II and surface analysis of Fd I, Fd II and PFOR suggest that a protein-protein complex is likely to be formed between aspartic acid/glutamic acid invariant residues of Fds and lysine residues surrounding the distal [4Fe-4S] cluster of PFOR. All of these studies are indicative of the involvement of electrostatic interactions between the two redox partners.  (+info)

S-layer-coated liposomes as a versatile system for entrapping and binding target molecules. (5/267)

In the present study, unilamellar liposomes coated with the crystalline bacterial cell surface layer (S-layer) protein of Bacillus stearothermophilus PV72/p2 were used as matrix for defined binding of functional molecules via the avidin- or streptavidin-biotin bridge. The liposomes were composed of dipalmitoyl phosphatidylcholine, cholesterol and hexadecylamine in a molar ratio of 10:5:4 and they had an average size of 180 nm. For introducing specific functions into the S-layer lattice without affecting substances encapsulated within the liposomes, crosslinking and activation reagents had to be identified which did not penetrate the liposomal membrane. Among different reagents, a hydrophilic dialdehyde generated by periodate cleavage of raffinose and a sulfo-succinimide activated dicarboxylic acid were found to be impermeable for the liposomal membrane. Both reagents completely crosslinked the S-layer lattice without interfering with its regular structure. Biotinylation of S-layer-coated liposomes was achieved by coupling p-diazobenzoyl biocytin which preferably reacts with the phenolic residue of tyrosine or with the imidazole ring of histidine. By applying this method, two biotin residues accessible for subsequent avidin binding were introduced per S-layer subunit. As visualized by labeling with biotinylated ferritin, an ordered monomolecular layer of streptavidin was formed on the surface of the S-layer-coated liposomes. As a second model system, biotinylated anti-human IgG was attached via the streptavidin bridge to the biotinylated S-layer-coated liposomes. The biological activity of the bound anti-human IgG was confirmed by ELISA.  (+info)

An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli. (6/267)

EmrE is an Escherichia coli 12-kDa protein that confers resistance to toxic compounds, by actively removing them in exchange with protons. The protein includes eight charged residues. Seven of these residues are located in the hydrophilic loops and can be replaced with either Cys or another amino acid bearing the same charge, without impairing transport activity. Glu-14 is the only charged residue in the membrane domain and is conserved in all the proteins of the family. We show here that this residue is the site of action of dicyclohexylcarbodiimide, a carbodiimide known to act in hydrophobic environments. When Glu-14 was replaced with either Cys or Asp, resistance was abolished. Whereas the E14C mutant displays no transport activity, the E14D protein shows efflux and exchange at rates about 30-50% that of the wild type. The maximal DeltapH-driven uptake rate of E14D is only 10% that of the wild type. The mutant shows a different pH profile in all the transport modes. Our results support the notion that Glu-14 is an essential part of a binding domain shared by substrates and protons but mutually exclusive in time. This notion provides the molecular basis for the obligatory exchange catalyzed by EmrE.  (+info)

Identification and characterization of a novel cAMP receptor protein in the cyanobacterium Synechocystis sp. PCC 6803. (7/267)

Three open reading frames of Synechocystis sp. PCC 6803 encoding a domain homologous with the cAMP binding domain of bacterial cAMP receptor protein were analyzed. These three open reading frames, sll1371, sll1924, and slr0593, which were named sycrp1, sycrp2, and sypk, respectively, were expressed in Escherichia coli as His-tagged or glutathione S-transferase fusion proteins and purified, and their biochemical properties were investigated. The results obtained for equilibrium dialysis measurements using these recombinant proteins suggest that SYCRP1 and SYPK show a binding affinity for cAMP while SYCRP2 does not. The dissociation constant of His-tagged SYCRP1 for cAMP is approximately 3 microM. A cross-linking experiment using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide revealed that His-tagged SYCRP1 forms a homodimer, and the presence or absence of cAMP does not affect the formation of the homodimer. The amino acid sequence reveals that SYCRP1 has a domain similar to the DNA binding domain of bacterial cAMP receptor protein in the COOH-terminal region. Consistent with this, His-tagged SYCRP1 forms a complex with DNA that contains the consensus sequence for E. coli cAMP receptor protein in the presence of cAMP. These results strongly suggest that SYCRP1 is a novel cAMP receptor protein.  (+info)

Comparison of the efficiency of various coupling systems in the acylation of model secondary amines with thymin-1-ylacetic acid. (8/267)

Peptide nucleic acids (PNAs) make a promising group of DNA analogues. The backbone of typical PNA oligomers is composed of N-(2-aminoethyl)glycine units, linked by the peptide bonds. The backbone secondary amine groups are acylated with carboxyalkyl derivatives of nucleobases. One of the PNA synthesis step causing some problems is the acylation of the monomer backbone with the nucleobase derivatives. The aim of the study was to compare the efficiency of various coupling systems in the acylation. Simple model compounds (piperidine and proline) were used, as well as equimolar amounts of the coupling reagents. Selected systems based on carbodiimides, aminium or phosphonium salts, mixed anhydride, and active esters were tested.  (+info)

United States Patent 3,632,620 PREPARATION OF ISOCYANATES FROM CARBODIHVIIDES Ehrenfried H. Kober, Hamden, and Wilhelm J. Schnabel, Branford, C0nn., assignors to Olin Mathieson Chemical Corporation No Drawing. Filed June 26, 1968, Ser. No. 740,064 Int. Cl. C07c 119/04 US. Cl. 260-453 P 4 Claims ABSTRACT OF THE DISCLOSURE Organic carbodiimides are reacted with carbon monoxide and/or carbon dioxide in the presence of a catalyst at an elevated pressure and elevated temperature to produce organic isocyanates. The catalyst is preferably at least one metal or compound of a metal found in Groups Ib, IIb, IIIb, IVa, IVb, Va, VIa, VIb, Illa, VIIa, VIII, and in the Lanthanide series of the Periodic Table. This invention relates to the preparation of organic isocyanates from organic carbodiimides. Organic isocyanates are used extensively in the preparation of urethane foams, coatings, and fibers, as well as in the preparation of insecticides, pesticides and the like. Commercial processes for preparing ...
The molecular biology of human genetic disorders is under intensive investigation at present. In those cases where the disorder is clearly defined in terms of altered gene structure, possibilities may exist for the correction of the disorder by insertion of normal genes through the process of DNA transfection. A possible method for the transfer of genetic material is by attempting to attach DNA to a protein which has specific receptors on cells and which undergoes receptor-mediated endocytosis. By this means one might be able to get DNA into cells. This thesis deals with experimental work on the chemical modification of human serum transferrin by means of water-soluble carbodiimides. The resulting N-acylurea transferrins bind DNA in a reversible manner. Characteristics and properties of the binding interactions are dealt with in detail. N-acylurea derivatives of transferrin were prepared with the water-soluble carbodiimides, N-ethyl-N -(3-dimethylaminopropyl) carbodiimide and N-ethyl-N ...
30. Dengyou Zhang, Deju Ye, Enguang Feng, Jinfang Wang, Jianmei Shi, Hualiang Jiang, and Hong Liu. Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O®N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid. J. Org. Chem. 2010, 75, 3552-3557.. 29. Lei Zhang, Deju Ye, Yu Zhou, Guannan Liu, Enguang Feng, Hualiang Jiang, and Hong Liu. Regioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinones. J. Org. Chem. 2010, 75, 3671-3677.. 28. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang, Jiang, and Hong Liu. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chem. 2011, 13, 397-405.. 27. Deju Ye, Jinfang Wang, Dengyou Deng, Enguang Feng, Hualiang Jiang, and Hong Liu. Advances in O-Sialylation. Progress in Chemistry 2010, 22, 91-100.. 26. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, ...
Seven- and eight-membered analogues of barbituric acid are easily accessible by insertion of carbodiimides into cyclic anhydrides catalyzed by the cationic hydroxo cluster [H|sub|3|/sub|Ru|sub|4|/sub| (C|sub|6|/sub|H|sub|6|/sub|)|sub|4|/sub| (OH)] |sup|2+|/sup|. Chérioux, Frédéric; Süss-Fink, Georg
Carboxyl groups on the phospholipid can be activated by using water soluble carbodiimide reagents like EDC. Including sulfo-NHS in the reaction mixture generates ester derivatives that couple more efficiently than does EDC intermediate alone. These reactive ester intermediates can further be conjugated to amine on the antibody to form stable amide bond.. ...
Carboxyl groups on the phospholipid can be activated by using water soluble carbodiimide reagents like EDC. Including sulfo-NHS in the reaction mixture generates ester derivatives that couple more efficiently than does EDC intermediate alone. These reactive ester intermediates can further be conjugated to amine on the antibody to form stable amide bond.. ...
A novel synthetic peptide corresponding to the eleven amino acid residues of the NH2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04 EXPERIMENT: 93020 TEST: 08 TIME: 09:14:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0 ------------------------------------------------------------------------------------------------------------------------------------ FINAL #1 MICE REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04 EXPERIMENT: 93020 TEST: 08 TIME: 09:14:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0 Mice(B6C3F1) ----------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES ...
The syntheses of representative diphenyl- and difluoroboron chelates of 2-hydroxycarbohydroxamic acids (glycolohydroxamic acids) are reported. Crystals of 5-(1-hydroxycyclohexyl)-2,2-diphenyl-1,3-dioxa-4-azonia-2-borata-4-cyclo pentene, 2a, are triclinic. ...
Human recombinant collagen can be cross-linked with a variety of chemical cross-linking agents. Cross-linking methods can be tuned to confer collagen-based scaffolds with specific physical properties, improved antigenicity and thermal stability without impeding the ability of the material to integrate into the surrounding tissue and to promote regeneration. Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. Carbodiimides are referred to as zero-length cross-linking agents as they are not incorporated into the final cross-link and thus pose minimal risk with respect to cytotoxicity. The resulting collagen-based scaffold possesses properties comparable to that of the human cornea and is thus suitable for use as a corneal substitute.. ...
TY - JOUR. T1 - Solid‐phase modification of chitosan hydrogel membranes and permeability properties of modified chitosan membranes. AU - Kubota, Naoji. AU - Kikuchi, Yasuo. AU - Mizuhara, Yukako. AU - Ishihara, Tatsumi. AU - Takita, Yusaku. PY - 1993/12/5. Y1 - 1993/12/5. N2 - A novel preparation method for modified chitosan membranes was developed. Chitosan hydrogel membranes were prepared by immersing an aqueous acetic acid solution of chitosan in KOH solution and modified with 3,3′‐dithiodipropionic acid (DTPA), which has a functional group that causes the thiol ⟷ disulfide transition through a redox reaction. It was smoothly modified with DTPA even in a solid‐phase modification when carbodiimides were used as the condensing reagents. The chitosan membrane modified with DTPA was reduced with tri‐n‐butyl phosphine (MSH membrane) and then oxidized with iodine (MSS membrane). Permeabilities of KCl, sucrose, and urea through these modified chitosan membranes were investigated. The ...
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl or EDAC-HCl) is a zero-length crosslinker (CAS # 25952-53-8) used to conjugate carboxyl functional groups to primary amines as found in peptides and proteins.
The use of protein cross-linking agents during bonding procedures has been recently proposed to improve bond durability. This study aimed to use zymography and in situ zymography techniques to evaluate the ability of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) cross-linker to inhibit matrix metalloproteinase (MMP) activity. The hypotheses tested were that: (1) bonding procedures increase dentin gelatinolytic activity and (2) EDC pre-treatment prevents this enzymatic activity. The zymographic assay was performed on protein extracts obtained from dentin powder treated with Optibond FL or Scotchbond 1XT with or without 0.3M EDC pre-treatment. For in situ zymography, adhesive/dentin interfaces were created with the same adhesives applied to acid-etched dentin slabs pre-treated or not with EDC conditioner. Zymograms revealed increased expression of dentin endogenous MMP-2 and -9 after adhesive application, while the use of EDC as a primer inactivated dentin gelatinases. Results of in situ zymograpy
Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked compl
Download the product note.. PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. The carbodiimide loading capacity is determined by 1H NMR (generation of Ac2O from AcOH in CDCl3). Amide formation may be conducted either without HOBt (Methods A), or with HOBt (Method B).. Excess HOBt can be scavenged after the reaction using MP-Carbonate Biotage® PS-Carbodiimide has been found to give superior results in comparison with N-Cyclohexylcarbodiimide-NI-Me PS resin and the quaternary carbodiimide resin P-EDC (Scheme 1, Table 1, click to enlarge table).. ...
Awhile back, I discussed dicyclohexylcarbodiimide: a condensing agent that helps turn biological monomers (like amino acids) into polymers (like proteins). People use it a lot on peptide synthesizers for this purpose, where the peptides are made in organic solvents. A related compound, EDAC, works in water:
Purpose : To evaluate the in vitro and in vivo drug release of a biodegradable injectable sheet made of cross-linked chitosan and gelatin mixture. Methods : Gelatin and chitosan were solved in water and 1% acetic acid at concentrations of 5 wt% and 2.5 wt%, respectively. Then, 5 wt% gelatin and 2.5 wt% chitosan was mixed at the ratio of 3 : 2 (vol). The drug was mixed with the 3 wt% gelatin/1 wt% chitosan mixture. Fluorescein isothiocyanate (FITC), FITC-labeled dextran 150 kDa (FD150), and FITC-labeled albumin (FITC-ALB) were used as drugs. Immedeately after adding water soluble carbodiimide in the gelatin/chitosan/drug mixture at final concentration of 10 mg/mL, 3 μL of the mixture was cast in the polydimethylsilane (PDMS) mold (internal diameter; 2.76 mm, depth; 0.5 mm). Then, the cross-linked gels were dried for 1 hour at room temperutere to make flexible sheets. The sheets were incubated in phosphate buffered saline (PBS) at 37 degrees C. The drug concentration in PBS were measured ...
About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
TY - JOUR. T1 - Structural biochemistry XIII. T2 - Synthesis of luteinizing hormone‐releasing hormone modification [Trp8]‐LH‐RH. AU - Pettit, George. AU - Smith, T. H.. PY - 1979/8. Y1 - 1979/8. N2 - A fragment condensation method was utilized for synthesis of the Trp8‐substituted luteinizing hormone‐releasing hormone (LH‐RH). Lert‐Butoxycarbonyl protection was employed for the α‐amino positions, and benzyl protection was used for the phenol group of Tyr and the imidazole nitrogen of His. Peptide bond‐forming reactions were performed using N‐hydroxysuccinimide (for Trp), dicyclohexylcarbodiimide‐1‐hydroxybenzotriazole, l‐ethyl‐3‐(3′‐dimethylaminopropyl)‐carbodiimide hydrochloride, or mixed carbonic anhydride methods. Biological evaluation of [Trp8]‐LH‐RH indicated no luteinizing hormone‐releasing activity or inhibition of luteinizing hormone release over the dose ranges studied.. AB - A fragment condensation method was utilized for synthesis of the ...
Animals and antibodies. Fertilized Hisex chicken eggs (Gallus domesticus) were obtained from a local farm and incubated at 37°C and 65% humidity in a forced-draft incubator. Staging of the embryos was according to Hamburger and Hamilton (1951). Embryos of 3-11 d of incubation (E3-E11) were used.. To block the function of N-cadherin, the following antibodies were used: rat monoclonal antibody NCD-2 against chicken N-cadherin (a kind gift from M. Takeichi, Kyoto University, Kyoto, Japan) (Hatta and Takeichi, 1986) and NCD-2 Fab fragments. In preliminary experiments, a polyclonal rabbit antiserum against N-cadherin (Hatta et al., 1988) was also used (a kind gift from M. Takeichi). Rat IgG (ChromPure; Dianova, Hamburg, Germany) and NCD-2 Fc fragments served as a control.. For immunohistochemistry, the following antibodies against cadherins were used: rat monoclonal antibody NCD-2 and a rabbit polyclonal antiserum against chicken N-cadherin (affinity purified by protein A); mouse monoclonal antibody ...
Ferrocenyl derivatives exhibit antitumor (Jaouen et al., 2004), antibacterial (Fouda et al., 2007), antifungal and antimalarial (Biot et al., 2004) activities. It was proved that the replacement of the aromatic group by the ferrocenyl moiety in penicillins and cephalosporins could improve their antibiotic activity (Edwards et al., 1975). Against this background, the title compound was chosen for X-ray structure analysis (Fig. 1).. In the title compound, the benzene ring makes dihedral angles of 10.84 (9) and 12.35 (9)°, respectively, with the substituted and unsubstituted cyclopentadienyl (Cp) rings of the ferrocenyl unit. In ferrocenyl unit, the two Cp rings are planar and are parallel to each other with a dihedral angle of 1.56 (9)° between them. The Fe atom lies in the middle of the two planes of Cp rings. The distances of the Fe1 atom from the centroids of the substituted and unsubstituted cyclopentadienyl rings are 1.646 (10) and 1.650 (12) Å, respectively. The Cg1-Fe1-Cg2 angle is ...
Kinetics and mechanisms of reactions of [ferrocenyl(methoxy)carbene]pentacarbonylchromium(0) with primary aliphatic amines in aqueous acetonitrile ...
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NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:03:02 Final#1/Mice Facility: BIORELIANCE Chemical CAS #: 693-13-0 Lock Date: 02/24/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:03:02 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG CONTROL MG/KG MG/KG MG/KG ...
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To establish the role of the ferrocenyl moiety in the antiplasmodial activity of ferroquine, compounds in which this moiety is replaced by the corresponding ruthenium-based moieties were synthesized and evaluated. In both the sensitive (D 10) and resistant (K1) strains of Plasmodium falciparum, ruthenoquine analogues showed comparable potency to ferroquine. This suggests that a probable role of the ferrocenyl fragment is to serve simply as a hydrophobic spacer group. In addition, ferroquine analogues with different aromatic substituents were synthesized and evaluated. Unexpectedly high activity for quinoline compounds lacking the 7-chloro substituent suggests the ferrocenyl moiety may have an additive and/or synergistic effect. (c) 2007 Elsevier Ltd. All rights reserved.. ...
Bicomponent electrospun nanofibers based on the combination of synthetic (i.e., aliphatic polyesters such as polycaprolactone (PCL)) and natural proteins (i.e., gelatin) have been extensively investigated as temporary platforms to instruct cells by the release of molecular/pharmaceutical signals for the regeneration of several tissues. Here, water soluble proteins (i.e., gelatin), strictly embedded to PCL, act as carriers of bioactive molecules, thus improving bioavailability and supporting cell activities during in vitro regeneration. However, these proteins are rapidly digested by enzymes, locally produced by many different cell types, both in vitro and in vivo, with significant drawbacks in the control of molecular release. Hence, we have investigated three post-processing strategies based on the use of different crosslinking agents-(1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) (EDC), glyceraldehyde (GC), and 1,4-butanediol diglycidyl ether (BDDGE)-to delay the dissolution time of
Kunshan Dingfa Chemical Co., Ltd. was established in 2012, relying on domestic first-class scientific research institutes technical resources, professional commitment to PU flame retardants, engineering plastics additives and carbodiimide, hydrolysis agent, anti-hydrolysis agent. To the continued technological innovation, stable and reliable product quality and professional and efficient services to win the recognition of many Chinese and foreign customers. Tel: 13661970701.
The Use of Ferrocenyl Ligands in Asymmetric Catalytic Hydrogenation – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 92595-MTE3N
Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.
Fluorescent Dye derived from coumarine. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0097) - Products - Abnova
Fluorescent dye derived from dipyrrometheneboron difluoride. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0129) - Products - Abnova
3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoicacid;ACHPA,(3S,4S)-4-Amino-5-cyclohexyl-3-hydroxy-pentanoicacid;105192-90-3;AC1NRAJQ;SCHEMBL7151431;ZINC2526313;AKOS015909015;AM001310;4-AMINO-5-CYCLOHEXYL-3-HYDROXY-PENTANOICACID;I14- ...
Seven ferrocenyl carbohydrate conjugates were synthesized. Coupling reactions of monosaccharide derivatives with ferrocene carbonyl chloride produced {6-N-(methyl 2,3,4-tri-O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}1- ferrocene carboxamide (3), {1-O-(2,3,4,6-tetra-O-benzyl-D-glucopyranose)}-1-ferrocene carboxylate (4), and {6O- (1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}-1-ferrocene carboxylate (5). Similarly, 1,1-bis(carbonyl chloride)ferrocene was coupled with the appropriate sugars to produce the disubstituted analogues bis {6-N-(methyl 2,3,4-tri- O-acetyl-6-amino-6-deoxy-R-D-glucopyranoside)}- 1,1-ferrocene carboxamide (8), bis {1-O-(2,3,4,6-tetra-O-benzyl-D- glucopyranose)}- 1,1-ferrocene carboxylate (9), and bis {6-O-(1,2,3,4-tetra-O-acetyl-beta-D-glucopyranose)}- 1,1-ferrocene carboxylate (10). {6-N-(Methyl-6-amino-6-deoxy-R-D-glucopyranoside)}-1-ferrocene carboxamide monohydrate (12) was synthesized via amide coupling of an activated ferrocenyl ester with the corresponding ...
0028]Preferred compounds of the invention include: [0029]N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]- ethyl}-amino)hexyl]oxy}ethoxy)methyl]phenyl}-N-phenylurea; [0030]4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hyd- roxyethyl}-2-(hydroxymethyl)phenol; [0031]N-(1,1-biphenyl-4-yl)-N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-- 3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}ethoxy)methyl]phenyl}urea; [0032]N-cyclohexyl-N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxy- methyl)phenyl]ethyl}amino)hexyl]oxy}ethoxy)methyl]phenyl}urea; [0033]4-[(1R)-2-({6-[2-(benzyloxy)ethoxy]hexyl}amino)-1-hydroxyethyl]-2-(- hydroxymethyl)phenol; [0034]4-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth- yl}amino)-hexyl]oxy}ethoxy)methyl]benzenesulfonamide; [0035]4-{(1R)-1-hydroxy-2-[(6-{2-[(4-iodobenzyl)oxy]ethoxy}hexyl)amino]et- hyl}-2-(hydroxymethyl)phenol; [0036]3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth- ...
Synthesis of L-SR15 and D-SR16. L-PGC (average molecular weight, 375 kDa) and D-PGC (average molecular weight, 344 kDa) were purchased from VisEn Medical, Inc. (Woburn, MA). L-PGC consists of poly-l-lysine (48 kDa) backbone grafted with monomethoxy-PEG (5 kDa, percent PEGylation, 30%). D-PGC consists of poly-d-lysine (44 kDa) grafted with PEG (percent PEGylation, 28%). The conjugation of Ce6 (Frontier Scientific, Logan, UT) to lysine residues in the PGC backbone was done using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl (EDC) as a coupling agent. In brief, total 1.7 mL mixture solutions, consisting of 1,140 μL of 9 μmol/L L-PGC or D-PGC in distilled water, 423 μL of 1.8 mmol/L Ce6 in 33 mmol/L Na2HPO4, and 120 μL of 13 mmol/L EDC in distilled water, were added into microcentrifuge tubes and gently shaken at 25°C in the dark for 20 hours. After reaction, the conjugates were purified by size exclusion chromatography (Bio-Gel P-10 gel, Bio-Rad, Hercules, CA) using 10 mmol/L phosphate ...
The compound Sn2O(CN2) was obtained as a brick-red crystalline powder from a solid-state reaction of equimolar amounts of SnCl2, SnO and Li2(CN2). Thermal analysis of the reaction indicates the formation of two intermediate compounds until Sn2O(CN2) is formed at 400 °C. The crystal structure of Sn2O(CN2) was
The syntheses of a number of aromatic aldonitrones of N-(2-hydroxyphenylmethyl)hydroxylamine and their subsequent reactions with diphenylborinic or carboxylic acid derivatives are reported. Crystals of 8-(4-dimethylaminophenylmethylene)-6,6-diphenyl-5,7-dioxa-8-azonia-6-bor ata-5H-6,7,8,9-tetrahydrobenzocycloheptene, 2b, are triclinic. ...
2-cyclohexyl-4-methyl-5-phenylmethoxypent-1-en-3-ol - chemical structural formula, chemical names, chemical properties, synthesis references
2,6-Piperidinedione, 3-(4-aminophenyl)-3-cyclohexyl-. CAS 115883-22-2. Molecular Formula:C17H22N2O2. Molecular Weight:C17H22N2O2.
Analytical methodology (No. S57) for determining levels of hydroxyquinone (123319) in aerosols collected on cellulose ester filters is described. An outline of principles of the methodology, demonstrated sensitivity and range of concentrations detectable, interference from other compounds, precision and accuracy of the method, advantages and disadvantages of the method and apparatus and reagents n
Allouch, F.; Vologdin, N. V.; Cattey, H.; Pirio, N.; Naoufal, D.; Kanj, A.; Smaliy, R. V.; Savateev, A.; Marchenko, A.; Hurieva, A. et al.; Koidan, H.; Kostyuk, A. N.; Hierso, J.-C.: Ferrocenyl (P,N)-diphosphines incorporating pyrrolyl, imidazolyl or benzazaphospholyl moieties: Synthesis, coordination to group 10 metals and performances in palladium-catalyzed arylation reactions. Journal of Organometallic Chemistry 735, pp. 38 - 46 (2013 ...
You are viewing an interactive 3D depiction of the molecule 5-ethyl-5-phenyl-1-(phenylsulfonyl)-2,4-imidazolidinedione (C17H16N2O4S) from the PQR.
Structure, properties, spectra, suppliers and links for: (3R,5R,6S,7S,9R,11E,13R,14R)-14-Ethyl-6-hydroxy-3,5,7,9,13-pentamethyloxacyclotetradec-11-ene-2,.
1ShareIf you are new to prepping, or interested but not sure that its for you, a great place to start out is with what to have in your Every Day Carry (EDC)...
The photosystem II subunit PsbS is essential for excess energy dissipation (qE); however, both lutein and zeaxanthin are needed for its full activation. Based on previous work, two models can be proposed in which PsbS is either 1) the gene product where the quenching activity is located or 2) a proton-sensing trigger that activates the quencher molecules. The first hypothesis requires xanthophyll binding to two PsbS-binding sites, each activated by the protonation of a dicyclohexylcarbodiimide-binding lumen-exposed glutamic acid residue. To assess the existence and properties of these xanthophyll-binding sites, PsbS point mutants on each of the two Glu residues PsbS E122Q and PsbS E226Q were crossed with the npq1/npq4 and lut2/ npq4 mutants lacking zeaxanthin and lutein, respectively. Double mutants E122Q/npq1 and E226Q/npq1 had no qE, whereas E122Q/lut2 and E226Q/lut2 showed a strong qE reduction with respect to both lut2 and single glutamate mutants. These findings exclude a specific ...
ID BASUB1_1_PE3152 STANDARD; PRT; 192 AA. AC BASUB1_1_PE3152; O32074; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE RecName: Full=Thiamine transporter ThiT;AltName: Full=Thiamine ECF DE transporter S component ThiT; (BASUB1_1.PE3152). GN Name=thiT; Synonyms=yuaJ; OrderedLocusNames=BSU30990; OS BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=224308; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BASUB1_1.PE3152. CC Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome. CC sequence. CC -!- ANNOTATIONS ORIGIN:THIT_BACSU CC -!- FUNCTION: Probably a thiamine-binding protein that interacts with CC the energy-coupling factor (ECF) ABC-transporter complex. Unlike CC classic ABC transporters this ECF transporter provides the energy CC necessary to transport a number of different substrates. The CC ...
0281] Materials Preparation--To activate the labeling beads, one ml of 0.2 μm Time Resolved Fluorescence latex microparticles (MPs) (Thermo Fisher Fremont, Calif.) at 10% (w/v) solids are combined with 1 ml of 0.5 M MES buffer (pH 6.0), 5.5 ml of deionized H20, 2.3 ml of 50 mg of N-hydroxysuccinimide (ISIHS; Product #24500; Pierce Chemical Company, Rockford, Ill.) per ml deionized H2O and 0.2 ml of 5 mg of 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride (EDC; Product #22980; Pierce Chemical Company) in deionized H2O. The resultant mixture is sonicated on ice for 40 seconds and then allowed to react on a shaker at RT for 30 minutes. The activated MPs are then centrifuged at 100 C at 10,000×g and washed three times with cold 50 mM MES buffer (pH 6.0) by resuspension and centrifugation cycles. In a typical procedure, the final pellet of MPs is suspended in 3.7 ml of 50 mM MES buffer (pH 6.0) and 2.3 ml of 1.0 mg of mouse anti-(Anti-NTproBNP peptide 63-71 antibody (Hytest., Turku, ...
Human serum albumins modified by covalently bound tolmetin or zomepirac were synthesized as models for similar products formed in vivo from acyl glucuronides. Activated esters of both drugs were prepared with 1-ethyl-3-(3-dimethylaminopropyl)-carbodi-imide, and then allowed to react with human serum albumin. Tryptic digests of both protein products were analysed by HPLC to identify peptides containing covalently bound drugs, and binding sites on albumin were identified by high-performance tandem MS. Three binding sites were common to both products, i.e. lysine-195, -199 and -351. Three further modified residues were identified for the tolmetin-albumin product, i.e. aspartic acid 1, and lysine-524 and -536. ...
(R)-(-)-Alpha-[(S)-2-(diphenylphosphino)ferrocenyl]benzylamine/ACM498580486 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
1-Cyclohexyl-1-butanol 4352-42-5 MSDS report, 1-Cyclohexyl-1-butanol MSDS safety technical specifications search, 1-Cyclohexyl-1-butanol safety information specifications ect.
Download the product note.. Biotage®PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates. Treatment of bound HOBt esters with an amine leads to amide formation in generally high purity without the need for further purification.. To date, the recommended procedure for loading PS-HOBt has required PyBroP as the coupling agent. We have developed an improved loading procedure based on the use of diisopropylcarbodiimide and DMAP. The new procedure has proven to be much more reliable, efficient, and cost effective. It requires fewer equivalents of carboxylic acid and does not require a double coupling as is the case when PyBroP is used.. Polymer-supported active esters offer some unique advantages for parallel amide synthesis. The polymer-supported active esters of PS-HOBt(HL) can be prepared using the ...
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.
Carboxyl is an organic functional group that is made out of a single carbon atom double bonded to an oxygen atom, and single bonded to a hydroxyl group. The
3-ethyl-1-phenyl-4,9-dihydro-3H-beta-carboline - chemical structural formula, chemical names, chemical properties, synthesis references
The C-N=C=N-C core of carbodiimides (N=C=N) is linear, being related to the structure of allene. The molecule has idealized C2 ... Carbodiimide Jeffrey S. Albert, Andrew D. Hamilton, Amy C. Hart, Xiaoming Feng, Lili Lin, Zhen Wang (2017). "1,3‐ ... Carbodiimides" (PDF). Journal of Organic Chemistry. 43 (25): 4689-4690. doi:10.1021/jo00419a001. Pri-Bar, I.; Schwartz, J. ( ... Jászay, Z. M.; Petneházy, I.; Töke, L.; Szajáni, B. (1987). "Preparation of Carbodiimides Using Phase-Transfer Catalysis". ...
Ulrich, Henri (2007). Chemistry and technology of carbodiimides. Chichester, England: John Wiley & Sons. ISBN 9780470065105.. ... and can be accessed by reaction of a carbodiimide with an organometallic compound such as methyl lithium. They are used widely ...
... hydrazination of Carbodiimides". Organometallics. 29 (22): 5946-5952. doi:10.1021/om100735q. Sarma, Rupam; Prajapati, Dipak (1 ...
Carbodiimide: A group of compounds with a general formula of R-N=C=N-R′, where R and R′ are either aliphatic (i.e., ... Agents with at least two chemically reactive groups such as carbodiimide or glutaraldehyde are to aid the conjugation of ... Bauminger, Sara; Wilchek, Meir (1980). "[7] the use of carbodiimides in the preparation of immunizing conjugates". ... diethylcarbodiimide) or aromatic (i.e., diphenylcarbodiimide). Conjugation using a carbodiimide requires the presence of α or ɛ ...
Li, Zhen; Mayer, Robert J.; Ofial, Armin R.; Mayr, Herbert (2020-04-27). "From Carbodiimides to Carbon Dioxide: Quantification ...
In terms of bonding, isocyanates are closely related to carbon dioxide (CO2) and carbodiimides (C(NR)2). The C−N=C=O unit that ... Li, Zhen; Mayer, Robert J.; Ofial, Armin R.; Mayr, Herbert (2020-04-27). "From Carbodiimides to Carbon Dioxide: Quantification ...
"From Carbodiimides to Carbon Dioxide: Quantification of the Electrophilic Reactivities of Heteroallenes". Journal of the ...
N,N′-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis. As a liquid, it is easier to handle than the commonly ... "Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides : Isolation of two N'- ...
... carbodiimide, also known as EDC, is a water-soluble carbodiimide that exhibits similar reactivity as CMC, and is also used for ... The carbodiimide moiety can also form covalent adducts at exposed nucleobases, which are uracil, and to a smaller extent ... 1-cyclohexyl-(2-morpholinoethyl)carbodiimide metho-p-toluene sulfonate, also known as CMCT or CMC, is the most commonly used ... Wang, PY; Sexton, AN; Culligan, WJ; Simon, MD (2019). "Carbodiimide reagents for the chemical probing of RNA structure in cells ...
Organic compounds called carbodiimides have the formula RN=C=NR. They are unrelated to imides. The PubChem links gives access ...
Conversely, the related carbodiimide 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is often used for solution-phase ... Carbodiimide activation opens the possibility for racemization of the activated amino acid. Racemization can be circumvented ... Carbodiimides such as dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are frequently used for amide bond ... Some coupling reagents omit the carbodiimide completely and incorporate the HOAt/HOBt moiety as an aminium/uronium or ...
... carbodiimide and allene adducts of hexakis (Trifluoromethyl t-botoxy) ditungsten. A comparison of ligand binding to W2(Ot-Bu)6 ...
... via activation with carbodiimide and subsequent coupling with amine); thiol (e.g. via maleimide or iodoacetamides); azide (e.g ...
... whose minor tautomer is carbodiimide, is an isomer of diazomethane. Less stable but still isolable isomers of diazomethane ...
These ligands are attached to the microbubbles using carbodiimide, maleimide, or biotin-streptavidin coupling. Biotin- ...
"Synthesis of iminoaziridines from carbodiimides and diazoesters : A new example of transition metal salt catalysed reactions of ...
Azie, O; Greenberg, ZF; Batich, CD; Dobson, JP (2019). "Carbodiimide Conjugation of Latent Transforming Growth Factor β1 to ...
2012), "Interstellar Carbodiimide (HNCNH) - A New Astronomical Detection from the GBT PRIMOS Survey via Maser Emission Features ... "Interstellar Carbodiimide (HNCNH): A New Astronomical Detection from the GBT PRIMOS Survey via Maser Emission Features". The ...
The Ab is conjugated to the superparamagnetic iron oxide NP by different methods including the carbodiimide method. The ...
... amidinium carbodiimide, is formed in primitive Earth experiments and is effective in dilute aqueous solutions. When present in ...
J. G. Moffatt, "Sulfoxide-Carbodiimide and Related Oxidations" in Oxidation vol. 2, R. L. Augustine, D. J. Trecker, Eds. ( ...
... the oligomycin sensitivity conferring protein is essential for dicyclohexyl carbodiimide-sensitive ATPase". Biochim. Biophys. ...
Macrolactamization was performed with 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) and iPr2NEt yielded the final ...
... (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such ... carbodiimide (EDCI)). For example, the stepwise liquid-phase synthesis of the dipeptide Z-L-Phg-L-Val-OMe yields the LL-product ... together with coupling reagents such as carbodiimides (for example dicyclohexylcarbodiimide (DCC)), diisopropylcarbodiimide ( ...
His research focuses on the following topics: solid-state chemistry quantum chemistry nitrides carbodiimides guanidinates ... the First Carbodiimide of a Magnetic Transition Metal, Inorg. Chem. 2005, 44, 3001. M. Wuttig, D. Lüsebrink, D. Wamwangi, W. ... Transition-metal carbodiimides as Molecular Negative Electrode Materials for Lithium- and Sodium-Ion Batteries with Excellent ...
A Nitridosilicate with a NPO-Zeolite Structure Type Containing Carbodiimide Ions". European Journal of Inorganic Chemistry. ...
All these methods are based on the unique reaction between pseudouridine and N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide ...
Carboxylic groups are functionalized by N,N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride (EDC) and N- ...
... enabling their attachment to amine-terminated surfaces through carbodiimide coupling chemistry. This process gives a high yield ...
The imine can be replaced by adding olefin to produce a cyclobutanone, carbonyl to produce a β-lactone, or carbodiimides to ...
As weak bases, carbodiimides bind to Lewis acids to give adducts. Carbodiimides are reagents for the Moffatt oxidation, a ... 1-cyclohexyl-(2-morpholinoethyl)carbodiimide metho-p-toluene sulfonate is a carbodiimide developed for the chemical probing of ... though this mostly occurs with low melting point carbodiimides that are liquids at room temperature. Solid diaryl carbodiimides ... Three principal resonance structures describe carbodiimides: RN=C=NR ↔ RN+≡C-N−R ↔ RN−-C≡N+R The N=C=N core is relatively ...
3) dicyclohexyl carbodiimide, (4) carbodiimide-containing evaporation residues formed in processes for preparing toluene ... was charged with 3 g. of diphenyl carbodiimide, 5 ml. of orthodichlorobenzene, and based upon the weight of the carbodiimide, ... More in detail, any organic carbodiimide, or a complex containing carbodiimide capable of forming an organic isocyanate under ... and carbodiimide proportion were changed where indicated in the table, which also shows conversion of carbodiimide and yield of ...
Inorganic carbodiimides (or cyanamides depending on the NCN2- form) design a family of compounds containing the carbodiimide ( ... and transition metal carbodiimides TNCN (T= Mn, Fe, Co, Ni, Cu) and Cr2(NCN)3have been reported. Non-metallic carbodiimides are ... this means that HgNCN can have either carbodiimide or cyanamide structures. Recently, metal carbodiimides are explored as anode ... Starting from 2000s, rare earth metal carbodiimides Ln2(NCN)3 (Ln = La, Ce, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm and Tm) ...
EDAC is a zero-length crosslinker that is routinely used for the covalent binding of amine-containing ligands to carboxylated microspheres.
Biotage® PS-Carbodiimide Solid-supported Coupling Agent PS-Carbodiimide is a neutral, bound carbodiimide that can be used for ... PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. The carbodiimide ... Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. In general, ... Biotage® PS-Carbodiimide is a neutral, bound carbodiimide for synthesis of amides and esters. Amide formation may be conducted ...
Solvent influences on the ^(15)N and ^(13)C chemical shifts of carbodiimides are small. Both the ^(13)C and ^(15)N spectra of l ... Carbodiimides Issa Yavari and John D. Roberts The Journal of Organic Chemistry 1978 43 (25), 4689-4693 DOI: 10.1021/jo00419a001 ... Information about the dimerization of carbodiimides in the presence of alkylating agents has been obtained from ^(15)N and ^(13 ... High-resolution, 18.25-MHz nitrogen-15 NMR spectra of several carbodiimides (1) have been obtained at the natural-abundance ...
Tin(II) oxide carbodiimide and its relationship to SnO K. Dolabdjian, A. L. Görne, R. Dronskowski, M. Ströbele and H. Meyer, ...
... and phosphine P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of ... carbodiimide. compound, followed by protonolysis of the resultant amidinate. -. (phospha)guanidinate. species ". {R′NC(ER)NR′}M ... P-H bonds to carbodiimides: an efficient route to propiolamidines, guanidines, and phosphaguanidines W. Zhang and Z. Hou, Org. ... P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of which were ...
... carbodiimide. 10. The method of claim 7, wherein the carbodiimide compound is included in an amount of 0.001 to 50 wt %, with ... carbodiimide. 6. The reverse osmosis membrane of claim 1, wherein the carbodiimide compound is included in an amount of 0.001 ... High permeate flux reverse osmosis membrane including carbodiimide compound and method of manufacturing the same ... In addition, the carbodiimide compound may be included in an amount of 0.01 to 5 wt % or 0.01 to 0.5 wt %, with respect to the ...
Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. Carbodiimides are ... Fabrication of a human recombinant collagen-based corneal substitute using carbodiimide chemistry. Islam, Mohammad Mirazul ... Biosynthetic corneal implant, Collagen, Carbodiimide, Collagen cross-linking, Collagen-based scaffold National Category Medical ...
Stahls new carbodiimide crosslinkers have now set a new standard, being the most sustainable, safe and easy-to-use option for ... Stahl has introduced two label-free carbodiimide crosslinkers - Picassian XL-755 and Picassian XL-762 - that offer a range of ... The two new label-free and VOC-free additions to the companys carbodiimide crosslinkers portfolio deliver a very high ... This increases the crosslinking capacity as both the carbodiimide and the additional reactive functional group contribute to ...
Yamamoto N, Yasuda K (1977) Use of a water soluble carbodiimide as a fixing reagent. Acta Histochem Cytochem 10:14-38Google ... Carbodiimide is preferable as a fixative for the cellular localization of F-VIII-R:AG. ... The use of a carbodiimide-containing fixative for the immunohistochemical demonstration of coagulation factor VIII in rat ... Kendall PA, Polak JM, Pearse AGE (1971) Carbodiimide fixation for immunohistochemistry: observations on the fixation of ...
|p|Silia|em||span style=color: rgb(97, 169, 211);|Prep|/span||/em| Dichlorotriazine has been designed as a reagent for amide coupling applications.|/p|
Free base form of Water-soluble carbodiimide. For applications see following entry. In the presence of CuCl2, (E)- or (Z)-2- ...
P, ,P, This method involves heating organic polyisocyanates in the presence of a carbodiimide forming catalyst consisting of a ... It is thus possible to obtain a polyisocyanate containing carbodiimide groups that no longer includes catalyst and therefore ... has more the possibility that the carbodiimide formation can continue during storage of the product In a particular embodiment ... An organic polyisocyanate conversion process polyisocyanates containing carbodiimide groups. ,/ ...
Gellan gum hydrogels cross-linked with carbodiimide stimulates vacuolation of human tooth-derived stem cells in vitro.. ... Gellan gum hydrogels cross-linked with carbodiimide stimulates vacuolation of human tooth-derived stem cells in vitro. Toxicol ...
... carbodiimide Hydrochloride CAS NO 25952-53-8, Europe 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride Suppliers, ... Europe 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride Manufacturers, related products of 1-Ethyl-3-(3- ... 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride. About 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide ... 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride; EDAC,HCl; N-Ethyl-N-(3-dimethylaminopropyl)carbodiimide ...
The third method is a Pauson-Khand type reaction of carbodiimides and ketenimines with alkynes in an intramolecular or ... A STUDY ON SYNTHESIS OF HETEROCYCLES VIA CROSS-CONJUGATED HETEROTRIENES AND FUNCTIONALIZED CARBODIIMIDES AS KEY INTERMEDIATES. ... The method [A] includes the initial annulation by intramolecular amine-nucleophilic addition to the carbodiimide-cumulene ... 2.Tandem cyclizations strategy of functionalized carbodiimides, which were prepared by the aza-Wittig reaction of ...
名称: EDC(1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) Thermo Scientific Pierce EDC is a water-soluble ... 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC or EDAC) is a zero-length crosslinking agent used to couple ... EDC(1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) 原装现货. ... carbodiimide crosslinker that activates carboxyl groups for spontaneous reaction with primary amines, enabling peptide ...
... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ...
Silylated carbodiimides in molecular and extended structures.. 60, In: Physical review B, pp. 3126-3139. APS, [Article]. ... Starting from the molecular model of N,N8-bis(trimethylsilyl)-carbodiimide and proceeding to extended models, we calculate that ... Starting from the molecular model of N,N8-bis(trimethylsilyl)-carbodiimide and proceeding to extended models, we calculate that ...
title = "Carbodiimide-based benzimidazole library method",. abstract = "Using carbodiimide reagents [1,3- ... Carbodiimide-based benzimidazole library method. / Carpenter, Richard D.; Deberdt, Patrick B.; Lam, Kit; Kurth, Mark J. ... Carpenter, R. D., Deberdt, P. B., Lam, K., & Kurth, M. J. (2006). Carbodiimide-based benzimidazole library method. Journal of ... Carpenter, Richard D. ; Deberdt, Patrick B. ; Lam, Kit ; Kurth, Mark J. / Carbodiimide-based benzimidazole library method. In: ...
Any compound with the general formula RN=C=NR which is a formal derivative of carbodiimide Explanation of carbodiimide ... Find out information about carbodiimide. HN=C=NH An unstable tautomer of cyanamide. ... carbodiimide. Also found in: Wikipedia. carbodiimide. [¦kär·bō′dī·ə‚mīd] (organic chemistry) HN=C=NH An unstable tautomer of ... Carbodiimide , Article about carbodiimide by The Free Dictionary https://encyclopedia2.thefreedictionary.com/carbodiimide ...
... carbodiimide hydrochloride (EDC-HCl or EDAC-HCl) is a zero-length crosslinker (CAS # 25952-53-8) used to conjugate carboxyl ... carbodiimide hydrochloride (EDC-HCl). My Account , Cart Contents , Checkout ...
... carbodiimide (EDC) cross-linker to inhibit matrix metalloproteinase (MMP) activity. The hypotheses tested were that: (1) ... Substantivity of Carbodiimide Inhibition on Dentinal Enzyme Activity over Time.. *A Mazzoni. , V Angeloni. , +6 authors. L ... Carbodiimide inactivation of MMPs and effect on dentin bonding.. *. Annalisa Mazzoni. , Fabianni Magalhães Apolonio. , +8 ... Transdentinal cytotoxicity of carbodiimide (EDC) and glutaraldehyde on odontoblast-like cells.. *D L S Scheffel. , L Bianchi. ...
Fluorescent group containing carbodiimides, their precursors and methods for their production. WO1989009282A1. 22 Mar 1989. 5 ... This example illustrates a compound of the present invention wherein a dye is linked to a carbodiimide. ... or a carboxylic acid activated by a carbodiimide to form an anhydride or mixed anhydride -OCORa or OCNRaNHRb,where Ra and Rb, ... a carbodiimide, a hydroxyl, iodoacetamide, an isocyanate, an isothiocyanate, a maleimide, an NHS ester, a phosphoramidite, a ...
New polymeric carbodiimides from LANXESS provide more reliable protection for plastics against hydrolysis. Tuesday, 28. June ... With Stabaxol P 110, as with the other new carbodiimides, LANXESS is addressing the trend towards customized antihydrolysis ... New polymeric carbodiimides from LANXESS provide more reliable protection for plastics against hydrolysis ... low-emission polymeric carbodiimides based on alternative raw materials. ...
Carbodiimides. Cell Survival. Collagenases. Cross-Linking Reagents. Extracellular Matrix. Gallbladder. Mice. Spectroscopy, ... Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells. * Authors: Ma DH, Lai JY, Cheng HY, ... Tailoring the properties of cholecyst-derived extracellular matrix using carbodiimide cross-linking. 2009, 20 (7-8):1049-63 J ... Tailoring the properties of cholecyst-derived extracellular matrix using carbodiimide cross-linking.. ...
Carbodiimide inactivation of matrix metalloproteinases in radicular dentine. In: Journal of Dentistry. 2019 ; Vol. 82. pp. 56- ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ...
Chemical Modification of Chloroplast Membranes.- A. Introduction.- B. N-ethylmaleimide (NEM).- C. Carbodiimides.- D. ...
  • The formation of an amide using a carbodiimide is a common reaction, but carries the risk of several side reactions. (wikipedia.org)
  • In direct comparison to HOBt and HOAt, ethyl (hydroxyimino)cyanoacetate (Oxyma) showed a remarkable capacity to inhibit racemization as an additive in carbodiimide mediated amide bond formation. (sigmaaldrich.com)
  • 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC or EDAC) is a zero-length crosslinking agent used to couple carboxyl groups to primary amines. (caigou.com.cn)
  • Using carbodiimide reagents [1,3-diisopropylcarbodiimide or N-(3-dimethylaminopropyl)-N′'-ethylcarbodiimide hydrochloride (EDC)], we have developed a mild, generalized, one-pot method that delivers N-2-arylaminobenzimidazole esters from commercially available aryl isothiocyanates and o-phenylenediamines. (elsevier.com)
  • 6 mg (3 [micro]mol) N-ethyl-N-(3-dimethyl aminopropyl) carbodiimide hydrochloride (EDC) and 1. (thefreedictionary.com)
  • Solutions of both N-hydroxysuccinimide (NHS) in DMF (1 mg/mL) and 1-ethyl- 3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) (2 mg/mL) in 100 mM carbonate buffer (pH 8. (thefreedictionary.com)
  • Conjugation of the first probe on the surface of CdTe QDs was carried out by mixing 1 mL of CdTe QDs, 20 [micro]g of the P1 and 50 [micro]L of 1-ethyl-3-(dimethylaminopropyl) carbodiimide hydrochloride (EDC). (thefreedictionary.com)
  • 10x molar excess 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS) were added to activate the carboxyl group of ELP to facilitate the formation of a peptide bond between ELP and PA (Figure 1). (thefreedictionary.com)
  • Also, the offered Ethyl Dimethylaminopropyl Carbodiimide Hydrochloride is used for proper mercerizing and scouring of cotton fabrics. (sagarlifescience.in)
  • In this study, we investigated the use of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and cyanoacrylate to enhance the strength of the tendon-suture interface. (elsevier.com)
  • Carbodiimides are reagents for the Moffatt oxidation, a protocol for conversion of an alcohol to a carbonyl (ketone or aldehyde) using dimethyl sulfoxide as the oxidizing agent: (CH3)2SO + (CyN)2C + R2CHOH → (CH3)2S + (CyNH)2CO + R2C=O Typically the sulfoxide and diimide are used in excess. (wikipedia.org)
  • The addition of Grignard reagents to carbodiimides. (nih.gov)
  • The most popular members of this family are peptide synthesis reagents based on benzotriazole derivatives such as HOBt or HOAt, both of which are also commonly used as additives in carbodiimide mediated peptide coupling. (sigmaaldrich.com)
  • Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked complex was formed. (biomedsearch.com)
  • Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the influence of SnCl 4 afforded N,N-bis(glycosyl)cyanamides for the first time. (elsevier.com)
  • Starting from the molecular model of N,N8-bis(trimethylsilyl)-carbodiimide and proceeding to extended models, we calculate that the energy hypersurface associated with the Si-N5C bond angle wN is very shallow, for both molecular and extended structures. (tu-darmstadt.de)
  • In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. (biotage.com)
  • Amine (1.0 equivalent) and acid (1.5 equivalent) in DCM (with 10% DMF added if necessary) was added to a dry reaction vessel and the mixture stirred for 10 min prior to addition of PS-Carbodiimide resin (2 equivalents) with a reaction solvent volume of 10 mL/g resin. (biotage.com)
  • Various metal complexes ( e.g. , lanthanides, early transition metals, and alkali metals ) can serve as catalyst precursors for the catalytic addition of alkyne C-H, amine N-H, and phosphine P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of which were difficult to prepare previously. (rsc.org)
  • and forming a polyamide active layer on the porous support by interfacially polymerizing a polyfunctional amine solution including a carbodiimide compound, and a polyfunctional acid halide compound solution. (freepatentsonline.com)
  • 6. The reverse osmosis membrane of claim 1, wherein the carbodiimide compound is included in an amount of 0.001 to 50 wt %, with respect to 100 w % of the polyfunctional amine solution. (freepatentsonline.com)
  • The method [A] includes the initial annulation by intramolecular amine-nucleophilic addition to the carbodiimide-cumulene carbon, followed by the second cyclization by reacting a group of newly formed amine with an inner functional group arranged. (nii.ac.jp)
  • In organic chemistry, a carbodiimide (systematic IUPAC name: methanediimine) is a functional group with the formula RN=C=NR. They are exclusively synthetic. (wikipedia.org)
  • CarboMAX improves standard carbodiimide chemistry by providing faster activation, less epimerization, and increased stabilization of acid-sensitive linkages (ex. (thefreedictionary.com)
  • Inorganic carbodiimides (or cyanamides depending on the NCN2- form) design a family of compounds containing the carbodiimide (or cyanamide) anion NCN2- bonded to an inorganic group such as a metal. (wikipedia.org)
  • HgNCN for example can adopt two structures with two different NCN configurations, this means that HgNCN can have either carbodiimide or cyanamide structures. (wikipedia.org)
  • During the operation of processes of this type a relatively large proportion of impurities such as polyureas, carbodiimides, biurets, isocyanate polymers, and the like are formed in the various process streams. (google.com)
  • The presence of organic carbodiimide type impurities in organic isocyanates is undesirable because it ties up valuable moieties capable of forming the desired isocyanate. (google.com)
  • It has now been discovered that the foregoing objects are accomplished when an organic carbodiimide is reacted with carbon monoxide and/ or carbon dioxide in the presence of a catalyst at an elevated pressure and elevated temperature to produce an organic isocyanate. (google.com)
  • More in detail, any organic carbodiimide, or a complex containing carbodiimide capable of forming an organic isocyanate under the reaction conditions applied may be employed as a reactant in the process of this invention. (google.com)
  • Il est ainsi possible d'obtenir un polyisocyanate contenant des groupes carbodiimide qui ne comporte plus de catalyseur et qui ne comporte donc plus la possibilité que la formation de carbodiimide puisse se poursuivre lors du stockage du produit Dans un mode de réalisation particulier, on utilise le procédé pour transformer le méthylènebis-(isocyanate de phényle) qui est normalement solide aux températures ambiantes. (google.com)
  • 1. A E. coli ST enterotoxin derivative which consists in E. coli enterotoxin crosslinked with a dialdehyde, a di-ketone, a carbodiimide, an isocyanate, an epihalohydrin or adifluoride. (patentgenius.com)
  • 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDCI) or glutaraldehyde] approach that covalently crosslinks adjacent collagen fibers to increase matrix density, strength and persistence (Yao et al. (thefreedictionary.com)
  • Transdentinal cytotoxicity of carbodiimide (EDC) and glutaraldehyde on odontoblast-like cells. (semanticscholar.org)
  • Excess HOBt can be scavenged after the reaction using MP-Carbonate Biotage® PS-Carbodiimide has been found to give superior results in comparison with N-Cyclohexylcarbodiimide-NI-Me PS resin and the quaternary carbodiimide resin P-EDC (Scheme 1, Table 1, click to enlarge table). (biotage.com)
  • No. 3,169,141, issued Feb. 9, 1965, describes a process for separating organic isocyanates from carbodiimides or reaction products containing them by solvent extraction with a liquid organic silane. (google.com)
  • A typical reagent for this process is mercuric oxide: (R(H)N)2CS + HgO → (RN)2C + HgS + H2O This reaction can often be conducted as stated, even though carbodiimides react with water. (wikipedia.org)
  • Isocyanates can be converted to carbodiimides with loss of carbon dioxide: 2 RN=C=O → (RN)2C + CO2 The reaction is catalyzed by phosphine oxides. (wikipedia.org)
  • 2.Tandem cyclizations strategy of functionalized carbodiimides, which were prepared by the aza-Wittig reaction of iminophosphoranes with isocyanates, has been developed for facile synthesis of a variety of ring-fused nitrogen-heterocyclic compounds such as imidazo-quinolines, imidazoimidazoles, imidazopyrimidines, imidazoquinazolines, imidazothiazines, pyrimidobenzothiazines, quinazolinobenzothiazines, and diazepinoquinolines. (nii.ac.jp)
  • The third method is a Pauson-Khand type reaction of carbodiimides and ketenimines with alkynes in an intramolecular or intermolecular fashion for the synthesis of pyrrolinone derivatives. (nii.ac.jp)
  • Thermo Scientific Pierce EDC is a water-soluble carbodiimide crosslinker that activates carboxyl groups for spontaneous reaction with primary amines, enabling peptide immobilization and hapten-carrier protein conjugation. (caigou.com.cn)
  • Reaction of glycosyl trimethylphosphinimides with carbon disulfide under mild conditions (room temperature, short reaction time) leads to symmetrical glycosyl carbodiimides. (elsevier.com)
  • The extent of polymer interdiffusion can be followed by FRET, while the extent of chemical reaction is traced by Fourier transform infrared spectroscopy (FTIR), taking advantage of the carbodiimide band at 2128 [cm. (thefreedictionary.com)
  • In the hair treated by internal modification with the carbodiimide reaction, 52.0 to 81.3% more lipids in group B were prevented than in the untreated hair. (nature.com)
  • Stahl has introduced two label-free carbodiimide crosslinkers - Picassian XL-755 and Picassian XL-762 - that offer a range of safe-to-use and sustainable crosslinker options for a variety of applications. (coatingsworld.com)
  • We are developing a low toxicity carbodiimide crosslinker to replace polyaziridine in water-based ink systems, and then designing an emulsion polymer specifically for PCDI crosslinkers. (thefreedictionary.com)
  • In organic synthesis, compounds containing the carbodiimide functionality are used as dehydration agents. (wikipedia.org)
  • But, the very first beginning of the metal carbodiimides/cyanamides goes back to the 1870s. (wikipedia.org)
  • Carbodiimide was used to strengthen the scaffold structure which made from gelatin mixed with carboxymethylcellulose (CMC) using freeze drying method. (cetjournal.it)
  • Characterization of the network structure of carbodiimide cross-linked gelatin gels. (ugent.be)
  • 260-453 P 4 Claims ABSTRACT OF THE DISCLOSURE Organic carbodiimides are reacted with carbon monoxide and/or carbon dioxide in the presence of a catalyst at an elevated pressure and elevated temperature to produce organic isocyanates. (google.com)
  • This method involves heating organic polyisocyanates in the presence of a carbodiimide forming catalyst consisting of a polystyrene substituted by organoarsine groups until a desired degree of conversion is obtained, then separating the product of the catalyst obtained. (google.com)
  • In modern organisms, condensation reactions are performed with the catalyst Dicyclohexyl Carbodiimide. (angelfire.com)
  • This invention relates to the preparation of organic isocyanates from organic carbodiimides. (google.com)
  • There is a great need at the present time for a simplified process for converting carbodiimides to organic isocyanates. (google.com)
  • Still another object of the invention is to provide a simplified technique for removing organic carbodiimides when they form in processes for preparing organic isocyanates. (google.com)
  • An organic polyisocyanate conversion process polyisocyanates containing carbodiimide groups. (google.com)
  • Immunohistochemically, coagulation F-VIII-R:AG in vascular endothelial cells can be demonstrated with antihuman F-VIII-R:AG antisera after fixation with 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, using both peroxidase and fluorescence techniques. (springer.com)
  • A well known carbodiimide is dicyclohexylcarbodiimide, which is used in peptide synthesis. (wikipedia.org)
  • 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate, for Peptide Synthesis is among Spectrum's high quality inventory of research products from TCI America. (spectrumchemical.com)
  • A side of binary carbodiimides, ternary (SrZn(NCN)2) and quaternary ones (Li2Sm2Sr(NCN)5 ) have also been prepared via solid-state metathesis. (wikipedia.org)
  • MNPs-Transf conjugates were linked with Epirubicin (Epi) by carbodiimide activation method. (thefreedictionary.com)
  • Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. (biotage.com)
  • Biotage®PS-Carbodiimide h. (biotage.com)
  • Unlike other inferior copies, the carbodiimide moiety in Biotage PS-Carbodiimide is not Benzylic by deisgn. (biotage.com)
  • The novel nano adsorbent caboxylmethyl - cyclodextrin conjugated magnetic nanoparticles (CMCD-MNPs) are prepared by grafting Carboxymethyl - cyclodextrin onto the magnetite surface via carbodiimide method. (thefreedictionary.com)
  • PS-Carbodiimide may also be used for the synthesis of pentafluorophenyl (PFP) activated esters (Table 3, click to enlarge) and N-hydroxysuccinimidyl esters. (biotage.com)
  • Some diaryl derivatives tend to convert to dimers and polymers upon standing at room temperature, though this mostly occurs with low melting point carbodiimides that are liquids at room temperature. (wikipedia.org)
  • Readily accessible unsymmetrical N,N′-bis(glycosyl)thioureas can be desulfurated and transformed into the corresponding carbodiimides using HgO in CHCl 3 /water at room temperature. (elsevier.com)
  • Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. (diva-portal.org)
  • The use of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide HCl (EDC) has recently been investigated for its effectiveness in the prevention of collagen degradation over time and the improvement of resin-dentin bond durability. (elsevier.com)
  • Nevertheless, we have shown that epoxy cross-linkers should be further explored in the fabrication of collagen-based hydrogels, as alternatives to or in conjunction with carbodiimide cross-linkers. (mdpi.com)
  • We recently had the privilege to be able to help some leading global coating producers to make a successful transition from traditional aziridines towards our carbodiimide technology,' said Raymond Bakker, global business director Polymers at Stahl Polymers. (coatingsworld.com)
  • Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of intra-radicular endogenous proteases. (elsevier.com)
  • Silia Bond ® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to Silia Bond Carbodiimide (Si-DCC). (silicycle.com)
  • A classic route to carbodiimides involves dehydrosulfurization of thioureas. (wikipedia.org)
  • Solid diaryl carbodiimides are more stable, but can slowly undergo hydrolysis in the presence of water over time. (wikipedia.org)
  • Cologne - The LANXESS Rhein Chemie Additives (ADD) business unit is expanding its large product range of hydrolysis stabilizers for plastics and polyurethanes with the addition of Stabaxol P 110, the first product in a new line of innovative, low-emission polymeric carbodiimides based on alternative raw materials. (lanxess.com)
  • Kunshan Dingfa Chemical Co., Ltd. was established in 2012, relying on domestic first-class scientific research institutes technical resources, professional commitment to PU flame retardants, engineering plastics additives and carbodiimide, hydrolysis agent, anti-hydrolysis agent. (dingfachemical.com)
  • From the perspective of bonding, carbodiimides are isoelectronic with carbon dioxide. (wikipedia.org)
  • Recently, metal carbodiimides are explored as anode materials for lithium and sodium ion batteries and found to present better specific capacities compared to conventional graphite and hard carbon electrode materials. (wikipedia.org)
  • This study aimed to use zymography and in situ zymography techniques to evaluate the ability of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) cross-linker to inhibit matrix metalloproteinase (MMP) activity. (semanticscholar.org)
  • PS-Carbodiimide is very stable and lost less than 5% of its initial activity when stored at 4 ˚C for 2 years. (biotage.com)
  • This increases the crosslinking capacity as both the carbodiimide and the additional reactive functional group contribute to the crosslinking. (coatingsworld.com)
  • abstract = "Objectives: The present in vitro study evaluated the effect of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), a cross-linking agent used as an additional therapeutic primer for luting fiber posts to radicular dentine to prevent hybrid layer degradation. (elsevier.com)
  • Solvent influences on the ^(15)N and ^(13)C chemical shifts of carbodiimides are small. (caltech.edu)
  • Kendall PA, Polak JM, Pearse AGE (1971) Carbodiimide fixation for immunohistochemistry: observations on the fixation of polypeptide hormones. (springer.com)
  • We showed that in situ hybridization (ISH) using conventional formaldehyde fixation results in substantial microRNA loss from mouse tissue sections, which can be prevented by fixation with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide that irreversibly immobilizes the microRNA at its 5' phosphate. (nih.gov)
  • Compared to other heteroallenes, carbodiimides are very weak electrophiles and only react with nucleophiles in the presence of catalysts, such as acids. (wikipedia.org)
  • Information about the dimerization of carbodiimides in the presence of alkylating agents has been obtained from ^(15)N and ^(13)C NMR. (caltech.edu)
  • CEM was cross-linked with varying cross-linking concentrations of N,N-(3-dimethyl aminopropyl)-N'-ethyl carbodiimide (EDC) in the presence of N-hydroxysuccinimide (NHS). (lenus.ie)
  • Ce procédé consiste à chauffer des polyisocyanates organiques en présence d'un catalyseur de formation de carbodiimide constitué par un polystyrène substitué par des groupes organoarsine jusqu'à ce qu'un degré désiré de conversion soit obtenu, puis à séparer le catalyseur du produit obtenu. (google.com)
  • The dehydration of N,N'-dialkylureas gives carbodiimides: (R(H)N)2CO → (RN)2C + H2O Phosphorus pentoxide and p-Toluenesulfonyl chloride have been used as a dehydrating agents. (wikipedia.org)
  • Carbodiimides are referred to as zero-length cross-linking agents as they are not incorporated into the final cross-link and thus pose minimal risk with respect to cytotoxicity. (diva-portal.org)
  • With Stabaxol P 110, as with the other new carbodiimides, LANXESS is addressing the trend towards customized antihydrolysis agents that are tailor-made for use in individual applications and are thus an enormous improvement with respect to stabilization performance, toxicology, emissions and handling. (lanxess.com)
  • 4. Other cross linking agents Carbodiimides 5. (slideshare.net)
  • Free base form of 'Water-soluble' carbodiimide. (alfa.com)
  • Gellan gum hydrogels cross-linked with carbodiimide stimulates vacuolation of human tooth-derived stem cells in vitro. (stembook.org)
  • Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells. (lenus.ie)
  • Calcium formamidinate derivatives by hydride insertion of carbodiimides. (nih.gov)
  • The acid 1 will react with the carbodiimide to produce the key intermediate: the O-acylisourea 2, which can be viewed as a carboxylic ester with an activated leaving group. (wikipedia.org)
  • Any compound with the general formula RN=C=NR which is a formal derivative of carbodiimide. (thefreedictionary.com)
  • Tailoring the properties of cholecyst-derived extracellular matrix using carbodiimide cross-linking. (lenus.ie)
  • was performed by using water-soluble carbodiimide. (nsti.org)