CarbodiimidesIsocyanates: Organic compounds that contain the -NCO radical.Metals, Rare Earth: A group of elements that include SCANDIUM; YTTRIUM; and the LANTHANOID SERIES ELEMENTS. Historically, the rare earth metals got their name from the fact that they were never found in their pure elemental form, but as an oxide. In addition they were very difficult to purify. They are not truly rare and comprise about 25% of the metals in the earth's crust.Cyanates: Organic salts of cyanic acid containing the -OCN radical.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Hydrostatic Pressure: The pressure due to the weight of fluid.Polyurethanes: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.Tin Compounds: Inorganic compounds that contain tin as an integral part of the molecule.Tin: A trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.Ethyldimethylaminopropyl Carbodiimide: Carbodiimide cross-linking reagent.Differential Thermal Analysis: Technique by which phase transitions of chemical reactions can be followed by observation of the heat absorbed or liberated.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Thermogravimetry: Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).Artificial Organs: Devices intended to replace non-functioning organs. They may be temporary or permanent. Since they are intended always to function as the natural organs they are replacing, they should be differentiated from PROSTHESES AND IMPLANTS and specific types of prostheses which, though also replacements for body parts, are frequently cosmetic (EYE, ARTIFICIAL) as well as functional (ARTIFICIAL LIMBS).Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Fixatives: Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Histological Techniques: Methods of preparing tissue for examination and study of the origin, structure, function, or pathology.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Organic Chemistry Phenomena: The conformation, properties, reaction processes, and the properties of the reactions of carbon compounds.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Dentin: The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)Dentin-Bonding Agents: Cements that act through infiltration and polymerization within the dentinal matrix and are used for dental restoration. They can be adhesive resins themselves, adhesion-promoting monomers, or polymerization initiators that act in concert with other agents to form a dentin-bonding system.Dental Bonding: An adhesion procedure for orthodontic attachments, such as plastic DENTAL CROWNS. This process usually includes the application of an adhesive material (DENTAL CEMENTS) and letting it harden in-place by light or chemical curing.Dentin Permeability: The property of dentin that permits passage of light, heat, cold, and chemical substances. It does not include penetration by microorganisms.Lathyrus: A plant genus in the family FABACEAE known for LATHYRISM poisoning.Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Hydrogel: A network of cross-linked hydrophilic macromolecules used in biomedical applications.Polymerization: Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).Hydrogels: Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Bioreactors: Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Siloxanes: Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.Tanning: A process of preserving animal hides by chemical treatment (using vegetable tannins, metallic sulfates, and sulfurized phenol compounds, or syntans) to make them immune to bacterial attack, and subsequent treatments with fats and greases to make them pliable. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.

Hairpin-shaped DNA duplexes with disulfide bonds in sugar-phosphate backbone as potential DNA reagents for crosslinking with proteins. (1/267)

Convenient approaches were described to incorporate -OP(=O)O(-)-SS-O(-)(O=)PO- bridges in hairpin-shaped DNA duplexes instead of regular phosphodiester linkages: (i) H2O2- or 2,2'-dipyridyldisulfide-mediated coupling of 3'- and 5'-thiophosphorylated oligonucleotides on complementary template and (ii) more selective template-guided autoligation of a preactivated oligonucleotide derivative with an oligomer carrying a terminal thiophosphoryl group. Dithiothreitol was found to cleave completely modified internucleotide linkage releasing starting oligonucleotides. The presence of complementary template as an intrinsic element of the molecule protects the hairpin DNA analog from spontaneous exchange of disulfide-linked oligomer fragments and makes it a good candidate for auto-crosslinking with cysteine-containing proteins.  (+info)

The effect of carboxyl group modification on the chromophore regeneration of archaeopsin-1 and bacterioopsin. (2/267)

Carboxyl group modification with DCCD and NCD-4 was employed to investigate the chemical environment of the side chains of archaeopsin-1 (aO-1) and bacterioopsin (bO). Some differences were observed between aO-1 and bO. Although DCCD or NCD-4 did not modify aO-1 in bleached membrane, they modified bO in bleached membrane and in mixed DMPC/CHAPS/SDS micelles at neutral pH, thereby affecting the opsin shift and the photocycle of the regenerated chromophore. On the contrary, after solubilization with SDS, aO-1 and bO were modified by DCCD and NCD-4, which decreased the chromophore regeneration. In particular, the reaction of aO-1 in SDS with NCD-4 proceeded in a 1:1 ratio at neutral pH. The fluorescence and CD spectra indicated that the modified site was located in the hydrophobic, asymmetrical region. Lysyl-endopeptidase digestion of NCD-4 modified aO-1 produced a fluorescent fragment and amino acid sequence analysis showed that Asp85 or Asp96 in helix C is a probable candidate for the modified residue at present. Kinetic CD measurements revealed that the introduction of N-acylurea at an Asp residue in helix C did not affect the formation of the transient intermediate but inhibited the side chain packing during refolding.  (+info)

Active site characterization of RNase Rs from Rhizopus stolonifer: involvement of histidine and lysine in catalysis and carboxylate in substrate binding. (3/267)

Chemical modification studies on purified RNase Rs revealed the involvement of a single histidine, lysine and carboxylate residue in the catalytic activity of the enzyme. RNA could not protect the enzyme against DEP- and TNBS-mediated inactivation whereas, substrate protection was observed in case of EDAC-mediated inactivation of the enzyme. K(m) and k(cat) values of the partially inactivated enzyme samples suggested that while histidine and lysine are involved in catalysis, carboxylate is involved in substrate binding. Active site nature of RNase Rs suggests that the inability of the enzyme to readily convert 2',3'-cyclic nucleotides to 3'-mononucleotides is probably due to the absence of catalytically active second histidine residue.  (+info)

Structural and kinetic studies of the pyruvate-ferredoxin oxidoreductase/ferredoxin complex from Desulfovibrio africanus. (4/267)

The pyruvate-ferredoxin oxidoreductase (PFOR)/ferredoxin (Fd) system of Desulfovibrio africanus has been investigated with the aim of understanding more fully protein-protein interaction and the kinetic characteristics of electron transfer between the two redox partners. D. africanus contains three Fds (Fd I, Fd II and Fd III) able to function as electron acceptors for PFOR. The complete amino acid sequence of Fd II was determined by automatic Edman degradation. It revealed a striking similarity to that of Fd I. The protein consists of 64 residues and its amino acid sequence is in agreement with a molecular mass of 6822.5 Da as measured by electrospray MS. Fd II contains five cysteine residues of which the first four (Cys11, Cys14, Cys17 and Cys54) are likely ligands for the single [4Fe-4S] cluster. A covalently cross-linked complex between PFOR and Fd I or Fd II was obtained by using a water soluble carbodiimide. This complex exhibited a stoichiometry of one ferredoxin for one PFOR subunit and is dependent on the ionic strength. The second-order rate constants for electron transfer between PFOR and Fds determined electrochemically using cyclic voltammetry are 7 x 107 M-1.s-1 for Fd I and 2 x 107 M-1.s-1 for Fd II and Fd III. The Km values of PFOR for Fd I and Fd II measured both by the electrochemical and the spectrophotometric method have been found to be 3 microM and 5 microM, respectively. The three-dimensional modelling of Fd II and surface analysis of Fd I, Fd II and PFOR suggest that a protein-protein complex is likely to be formed between aspartic acid/glutamic acid invariant residues of Fds and lysine residues surrounding the distal [4Fe-4S] cluster of PFOR. All of these studies are indicative of the involvement of electrostatic interactions between the two redox partners.  (+info)

S-layer-coated liposomes as a versatile system for entrapping and binding target molecules. (5/267)

In the present study, unilamellar liposomes coated with the crystalline bacterial cell surface layer (S-layer) protein of Bacillus stearothermophilus PV72/p2 were used as matrix for defined binding of functional molecules via the avidin- or streptavidin-biotin bridge. The liposomes were composed of dipalmitoyl phosphatidylcholine, cholesterol and hexadecylamine in a molar ratio of 10:5:4 and they had an average size of 180 nm. For introducing specific functions into the S-layer lattice without affecting substances encapsulated within the liposomes, crosslinking and activation reagents had to be identified which did not penetrate the liposomal membrane. Among different reagents, a hydrophilic dialdehyde generated by periodate cleavage of raffinose and a sulfo-succinimide activated dicarboxylic acid were found to be impermeable for the liposomal membrane. Both reagents completely crosslinked the S-layer lattice without interfering with its regular structure. Biotinylation of S-layer-coated liposomes was achieved by coupling p-diazobenzoyl biocytin which preferably reacts with the phenolic residue of tyrosine or with the imidazole ring of histidine. By applying this method, two biotin residues accessible for subsequent avidin binding were introduced per S-layer subunit. As visualized by labeling with biotinylated ferritin, an ordered monomolecular layer of streptavidin was formed on the surface of the S-layer-coated liposomes. As a second model system, biotinylated anti-human IgG was attached via the streptavidin bridge to the biotinylated S-layer-coated liposomes. The biological activity of the bound anti-human IgG was confirmed by ELISA.  (+info)

An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli. (6/267)

EmrE is an Escherichia coli 12-kDa protein that confers resistance to toxic compounds, by actively removing them in exchange with protons. The protein includes eight charged residues. Seven of these residues are located in the hydrophilic loops and can be replaced with either Cys or another amino acid bearing the same charge, without impairing transport activity. Glu-14 is the only charged residue in the membrane domain and is conserved in all the proteins of the family. We show here that this residue is the site of action of dicyclohexylcarbodiimide, a carbodiimide known to act in hydrophobic environments. When Glu-14 was replaced with either Cys or Asp, resistance was abolished. Whereas the E14C mutant displays no transport activity, the E14D protein shows efflux and exchange at rates about 30-50% that of the wild type. The maximal DeltapH-driven uptake rate of E14D is only 10% that of the wild type. The mutant shows a different pH profile in all the transport modes. Our results support the notion that Glu-14 is an essential part of a binding domain shared by substrates and protons but mutually exclusive in time. This notion provides the molecular basis for the obligatory exchange catalyzed by EmrE.  (+info)

Identification and characterization of a novel cAMP receptor protein in the cyanobacterium Synechocystis sp. PCC 6803. (7/267)

Three open reading frames of Synechocystis sp. PCC 6803 encoding a domain homologous with the cAMP binding domain of bacterial cAMP receptor protein were analyzed. These three open reading frames, sll1371, sll1924, and slr0593, which were named sycrp1, sycrp2, and sypk, respectively, were expressed in Escherichia coli as His-tagged or glutathione S-transferase fusion proteins and purified, and their biochemical properties were investigated. The results obtained for equilibrium dialysis measurements using these recombinant proteins suggest that SYCRP1 and SYPK show a binding affinity for cAMP while SYCRP2 does not. The dissociation constant of His-tagged SYCRP1 for cAMP is approximately 3 microM. A cross-linking experiment using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide revealed that His-tagged SYCRP1 forms a homodimer, and the presence or absence of cAMP does not affect the formation of the homodimer. The amino acid sequence reveals that SYCRP1 has a domain similar to the DNA binding domain of bacterial cAMP receptor protein in the COOH-terminal region. Consistent with this, His-tagged SYCRP1 forms a complex with DNA that contains the consensus sequence for E. coli cAMP receptor protein in the presence of cAMP. These results strongly suggest that SYCRP1 is a novel cAMP receptor protein.  (+info)

Comparison of the efficiency of various coupling systems in the acylation of model secondary amines with thymin-1-ylacetic acid. (8/267)

Peptide nucleic acids (PNAs) make a promising group of DNA analogues. The backbone of typical PNA oligomers is composed of N-(2-aminoethyl)glycine units, linked by the peptide bonds. The backbone secondary amine groups are acylated with carboxyalkyl derivatives of nucleobases. One of the PNA synthesis step causing some problems is the acylation of the monomer backbone with the nucleobase derivatives. The aim of the study was to compare the efficiency of various coupling systems in the acylation. Simple model compounds (piperidine and proline) were used, as well as equimolar amounts of the coupling reagents. Selected systems based on carbodiimides, aminium or phosphonium salts, mixed anhydride, and active esters were tested.  (+info)

United States Patent 3,632,620 PREPARATION OF ISOCYANATES FROM CARBODIHVIIDES Ehrenfried H. Kober, Hamden, and Wilhelm J. Schnabel, Branford, C0nn., assignors to Olin Mathieson Chemical Corporation No Drawing. Filed June 26, 1968, Ser. No. 740,064 Int. Cl. C07c 119/04 US. Cl. 260-453 P 4 Claims ABSTRACT OF THE DISCLOSURE Organic carbodiimides are reacted with carbon monoxide and/or carbon dioxide in the presence of a catalyst at an elevated pressure and elevated temperature to produce organic isocyanates. The catalyst is preferably at least one metal or compound of a metal found in Groups Ib, IIb, IIIb, IVa, IVb, Va, VIa, VIb, Illa, VIIa, VIII, and in the Lanthanide series of the Periodic Table. This invention relates to the preparation of organic isocyanates from organic carbodiimides. Organic isocyanates are used extensively in the preparation of urethane foams, coatings, and fibers, as well as in the preparation of insecticides, pesticides and the like. Commercial processes for preparing ...
30. Dengyou Zhang, Deju Ye, Enguang Feng, Jinfang Wang, Jianmei Shi, Hualiang Jiang, and Hong Liu. Highly alpha-Selective Synthesis of Sialyl Spirohydantoins by Regiospecific Domino Condensation/O®N Acyl Migration/N-Sialylation of Carbodiimides with Peracetylated Sialic Acid. J. Org. Chem. 2010, 75, 3552-3557.. 29. Lei Zhang, Deju Ye, Yu Zhou, Guannan Liu, Enguang Feng, Hualiang Jiang, and Hong Liu. Regioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinones. J. Org. Chem. 2010, 75, 3671-3677.. 28. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang, Jiang, and Hong Liu. Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chem. 2011, 13, 397-405.. 27. Deju Ye, Jinfang Wang, Dengyou Deng, Enguang Feng, Hualiang Jiang, and Hong Liu. Advances in O-Sialylation. Progress in Chemistry 2010, 22, 91-100.. 26. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, ...
Carboxyl groups on the phospholipid can be activated by using water soluble carbodiimide reagents like EDC. Including sulfo-NHS in the reaction mixture generates ester derivatives that couple more efficiently than does EDC intermediate alone. These reactive ester intermediates can further be conjugated to amine on the antibody to form stable amide bond.. ...
Carboxyl groups on the phospholipid can be activated by using water soluble carbodiimide reagents like EDC. Including sulfo-NHS in the reaction mixture generates ester derivatives that couple more efficiently than does EDC intermediate alone. These reactive ester intermediates can further be conjugated to amine on the antibody to form stable amide bond.. ...
A novel synthetic peptide corresponding to the eleven amino acid residues of the NH2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04 EXPERIMENT: 93020 TEST: 08 TIME: 09:14:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0 ------------------------------------------------------------------------------------------------------------------------------------ FINAL #1 MICE REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst DIISOPROPYLCARBODIIMIDE DATE: 07/19/04 EXPERIMENT: 93020 TEST: 08 TIME: 09:14:52 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: N01-ES-05451 ROUTE: SKIN APPLICATION NTP C#: 93020D PATHOLOGIST: FARNELL, DANIEL CAS: 693-13-0 Mice(B6C3F1) ----------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES ...
The syntheses of representative diphenyl- and difluoroboron chelates of 2-hydroxycarbohydroxamic acids (glycolohydroxamic acids) are reported. Crystals of 5-(1-hydroxycyclohexyl)-2,2-diphenyl-1,3-dioxa-4-azonia-2-borata-4-cyclo pentene, 2a, are triclinic. ...
Human recombinant collagen can be cross-linked with a variety of chemical cross-linking agents. Cross-linking methods can be tuned to confer collagen-based scaffolds with specific physical properties, improved antigenicity and thermal stability without impeding the ability of the material to integrate into the surrounding tissue and to promote regeneration. Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. Carbodiimides are referred to as zero-length cross-linking agents as they are not incorporated into the final cross-link and thus pose minimal risk with respect to cytotoxicity. The resulting collagen-based scaffold possesses properties comparable to that of the human cornea and is thus suitable for use as a corneal substitute.. ...
The use of protein cross-linking agents during bonding procedures has been recently proposed to improve bond durability. This study aimed to use zymography and in situ zymography techniques to evaluate the ability of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) cross-linker to inhibit matrix metalloproteinase (MMP) activity. The hypotheses tested were that: (1) bonding procedures increase dentin gelatinolytic activity and (2) EDC pre-treatment prevents this enzymatic activity. The zymographic assay was performed on protein extracts obtained from dentin powder treated with Optibond FL or Scotchbond 1XT with or without 0.3M EDC pre-treatment. For in situ zymography, adhesive/dentin interfaces were created with the same adhesives applied to acid-etched dentin slabs pre-treated or not with EDC conditioner. Zymograms revealed increased expression of dentin endogenous MMP-2 and -9 after adhesive application, while the use of EDC as a primer inactivated dentin gelatinases. Results of in situ zymograpy
Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked compl
Download the product note.. PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. The carbodiimide loading capacity is determined by 1H NMR (generation of Ac2O from AcOH in CDCl3). Amide formation may be conducted either without HOBt (Methods A), or with HOBt (Method B).. Excess HOBt can be scavenged after the reaction using MP-Carbonate Biotage® PS-Carbodiimide has been found to give superior results in comparison with N-Cyclohexylcarbodiimide-NI-Me PS resin and the quaternary carbodiimide resin P-EDC (Scheme 1, Table 1, click to enlarge table).. ...
Purpose : To evaluate the in vitro and in vivo drug release of a biodegradable injectable sheet made of cross-linked chitosan and gelatin mixture. Methods : Gelatin and chitosan were solved in water and 1% acetic acid at concentrations of 5 wt% and 2.5 wt%, respectively. Then, 5 wt% gelatin and 2.5 wt% chitosan was mixed at the ratio of 3 : 2 (vol). The drug was mixed with the 3 wt% gelatin/1 wt% chitosan mixture. Fluorescein isothiocyanate (FITC), FITC-labeled dextran 150 kDa (FD150), and FITC-labeled albumin (FITC-ALB) were used as drugs. Immedeately after adding water soluble carbodiimide in the gelatin/chitosan/drug mixture at final concentration of 10 mg/mL, 3 μL of the mixture was cast in the polydimethylsilane (PDMS) mold (internal diameter; 2.76 mm, depth; 0.5 mm). Then, the cross-linked gels were dried for 1 hour at room temperutere to make flexible sheets. The sheets were incubated in phosphate buffered saline (PBS) at 37 degrees C. The drug concentration in PBS were measured ...
About this substance This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here.. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). The information is aggregated from the data coming from REACH substance registrations provided by industry.. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet.. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information ...
Animals and antibodies. Fertilized Hisex chicken eggs (Gallus domesticus) were obtained from a local farm and incubated at 37°C and 65% humidity in a forced-draft incubator. Staging of the embryos was according to Hamburger and Hamilton (1951). Embryos of 3-11 d of incubation (E3-E11) were used.. To block the function of N-cadherin, the following antibodies were used: rat monoclonal antibody NCD-2 against chicken N-cadherin (a kind gift from M. Takeichi, Kyoto University, Kyoto, Japan) (Hatta and Takeichi, 1986) and NCD-2 Fab fragments. In preliminary experiments, a polyclonal rabbit antiserum against N-cadherin (Hatta et al., 1988) was also used (a kind gift from M. Takeichi). Rat IgG (ChromPure; Dianova, Hamburg, Germany) and NCD-2 Fc fragments served as a control.. For immunohistochemistry, the following antibodies against cadherins were used: rat monoclonal antibody NCD-2 and a rabbit polyclonal antiserum against chicken N-cadherin (affinity purified by protein A); mouse monoclonal antibody ...
Ferrocenyl derivatives exhibit antitumor (Jaouen et al., 2004), antibacterial (Fouda et al., 2007), antifungal and antimalarial (Biot et al., 2004) activities. It was proved that the replacement of the aromatic group by the ferrocenyl moiety in penicillins and cephalosporins could improve their antibiotic activity (Edwards et al., 1975). Against this background, the title compound was chosen for X-ray structure analysis (Fig. 1).. In the title compound, the benzene ring makes dihedral angles of 10.84 (9) and 12.35 (9)°, respectively, with the substituted and unsubstituted cyclopentadienyl (Cp) rings of the ferrocenyl unit. In ferrocenyl unit, the two Cp rings are planar and are parallel to each other with a dihedral angle of 1.56 (9)° between them. The Fe atom lies in the middle of the two planes of Cp rings. The distances of the Fe1 atom from the centroids of the substituted and unsubstituted cyclopentadienyl rings are 1.646 (10) and 1.650 (12) Å, respectively. The Cg1-Fe1-Cg2 angle is ...
Kinetics and mechanisms of reactions of [ferrocenyl(methoxy)carbene]pentacarbonylchromium(0) with primary aliphatic amines in aqueous acetonitrile ...
NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:03:02 Final#1/Mice Facility: BIORELIANCE Chemical CAS #: 693-13-0 Lock Date: 02/24/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:03:02 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG CONTROL MG/KG MG/KG MG/KG ...
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To establish the role of the ferrocenyl moiety in the antiplasmodial activity of ferroquine, compounds in which this moiety is replaced by the corresponding ruthenium-based moieties were synthesized and evaluated. In both the sensitive (D 10) and resistant (K1) strains of Plasmodium falciparum, ruthenoquine analogues showed comparable potency to ferroquine. This suggests that a probable role of the ferrocenyl fragment is to serve simply as a hydrophobic spacer group. In addition, ferroquine analogues with different aromatic substituents were synthesized and evaluated. Unexpectedly high activity for quinoline compounds lacking the 7-chloro substituent suggests the ferrocenyl moiety may have an additive and/or synergistic effect. (c) 2007 Elsevier Ltd. All rights reserved.. ...
Bicomponent electrospun nanofibers based on the combination of synthetic (i.e., aliphatic polyesters such as polycaprolactone (PCL)) and natural proteins (i.e., gelatin) have been extensively investigated as temporary platforms to instruct cells by the release of molecular/pharmaceutical signals for the regeneration of several tissues. Here, water soluble proteins (i.e., gelatin), strictly embedded to PCL, act as carriers of bioactive molecules, thus improving bioavailability and supporting cell activities during in vitro regeneration. However, these proteins are rapidly digested by enzymes, locally produced by many different cell types, both in vitro and in vivo, with significant drawbacks in the control of molecular release. Hence, we have investigated three post-processing strategies based on the use of different crosslinking agents-(1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) (EDC), glyceraldehyde (GC), and 1,4-butanediol diglycidyl ether (BDDGE)-to delay the dissolution time of
The Use of Ferrocenyl Ligands in Asymmetric Catalytic Hydrogenation – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 92595-MTE3N
Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.
Fluorescent Dye derived from coumarine. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0097) - Products - Abnova
Fluorescent dye derived from dipyrrometheneboron difluoride. Water insoluble and forms stable amide bond with primary amines via carbodiimide activation. (U0129) - Products - Abnova
0028]Preferred compounds of the invention include: [0029]N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]- ethyl}-amino)hexyl]oxy}ethoxy)methyl]phenyl}-N-phenylurea; [0030]4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hyd- roxyethyl}-2-(hydroxymethyl)phenol; [0031]N-(1,1-biphenyl-4-yl)-N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-- 3-(hydroxymethyl)phenyl]ethyl}amino) hexyl]oxy}ethoxy)methyl]phenyl}urea; [0032]N-cyclohexyl-N-{3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxy- methyl)phenyl]ethyl}amino)hexyl]oxy}ethoxy)methyl]phenyl}urea; [0033]4-[(1R)-2-({6-[2-(benzyloxy)ethoxy]hexyl}amino)-1-hydroxyethyl]-2-(- hydroxymethyl)phenol; [0034]4-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth- yl}amino)-hexyl]oxy}ethoxy)methyl]benzenesulfonamide; [0035]4-{(1R)-1-hydroxy-2-[(6-{2-[(4-iodobenzyl)oxy]ethoxy}hexyl)amino]et- hyl}-2-(hydroxymethyl)phenol; [0036]3-[(2-{[6-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth- ...
Synthesis of L-SR15 and D-SR16. L-PGC (average molecular weight, 375 kDa) and D-PGC (average molecular weight, 344 kDa) were purchased from VisEn Medical, Inc. (Woburn, MA). L-PGC consists of poly-l-lysine (48 kDa) backbone grafted with monomethoxy-PEG (5 kDa, percent PEGylation, 30%). D-PGC consists of poly-d-lysine (44 kDa) grafted with PEG (percent PEGylation, 28%). The conjugation of Ce6 (Frontier Scientific, Logan, UT) to lysine residues in the PGC backbone was done using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl (EDC) as a coupling agent. In brief, total 1.7 mL mixture solutions, consisting of 1,140 μL of 9 μmol/L L-PGC or D-PGC in distilled water, 423 μL of 1.8 mmol/L Ce6 in 33 mmol/L Na2HPO4, and 120 μL of 13 mmol/L EDC in distilled water, were added into microcentrifuge tubes and gently shaken at 25°C in the dark for 20 hours. After reaction, the conjugates were purified by size exclusion chromatography (Bio-Gel P-10 gel, Bio-Rad, Hercules, CA) using 10 mmol/L phosphate ...
The compound Sn2O(CN2) was obtained as a brick-red crystalline powder from a solid-state reaction of equimolar amounts of SnCl2, SnO and Li2(CN2). Thermal analysis of the reaction indicates the formation of two intermediate compounds until Sn2O(CN2) is formed at 400 °C. The crystal structure of Sn2O(CN2) was
Department of Chemistry, UBC Faculty of Science. Vancouver Campus. 2036 Main Mall. Vancouver, BC Canada V6T 1Z1. Tel: 604.822.3266. Fax: 604.822.2847. ...
2-cyclohexyl-4-methyl-5-phenylmethoxypent-1-en-3-ol - chemical structural formula, chemical names, chemical properties, synthesis references
The photosystem II subunit PsbS is essential for excess energy dissipation (qE); however, both lutein and zeaxanthin are needed for its full activation. Based on previous work, two models can be proposed in which PsbS is either 1) the gene product where the quenching activity is located or 2) a proton-sensing trigger that activates the quencher molecules. The first hypothesis requires xanthophyll binding to two PsbS-binding sites, each activated by the protonation of a dicyclohexylcarbodiimide-binding lumen-exposed glutamic acid residue. To assess the existence and properties of these xanthophyll-binding sites, PsbS point mutants on each of the two Glu residues PsbS E122Q and PsbS E226Q were crossed with the npq1/npq4 and lut2/ npq4 mutants lacking zeaxanthin and lutein, respectively. Double mutants E122Q/npq1 and E226Q/npq1 had no qE, whereas E122Q/lut2 and E226Q/lut2 showed a strong qE reduction with respect to both lut2 and single glutamate mutants. These findings exclude a specific ...
ID BASUB1_1_PE3152 STANDARD; PRT; 192 AA. AC BASUB1_1_PE3152; O32074; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE RecName: Full=Thiamine transporter ThiT;AltName: Full=Thiamine ECF DE transporter S component ThiT; (BASUB1_1.PE3152). GN Name=thiT; Synonyms=yuaJ; OrderedLocusNames=BSU30990; OS BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=224308; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BASUB1_1.PE3152. CC Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome. CC sequence. CC -!- ANNOTATIONS ORIGIN:THIT_BACSU CC -!- FUNCTION: Probably a thiamine-binding protein that interacts with CC the energy-coupling factor (ECF) ABC-transporter complex. Unlike CC classic ABC transporters this ECF transporter provides the energy CC necessary to transport a number of different substrates. The CC ...
0281] Materials Preparation--To activate the labeling beads, one ml of 0.2 μm Time Resolved Fluorescence latex microparticles (MPs) (Thermo Fisher Fremont, Calif.) at 10% (w/v) solids are combined with 1 ml of 0.5 M MES buffer (pH 6.0), 5.5 ml of deionized H20, 2.3 ml of 50 mg of N-hydroxysuccinimide (ISIHS; Product #24500; Pierce Chemical Company, Rockford, Ill.) per ml deionized H2O and 0.2 ml of 5 mg of 1-ethyl-3-(3-dimethylamino-propyl) carbodiimide hydrochloride (EDC; Product #22980; Pierce Chemical Company) in deionized H2O. The resultant mixture is sonicated on ice for 40 seconds and then allowed to react on a shaker at RT for 30 minutes. The activated MPs are then centrifuged at 100 C at 10,000×g and washed three times with cold 50 mM MES buffer (pH 6.0) by resuspension and centrifugation cycles. In a typical procedure, the final pellet of MPs is suspended in 3.7 ml of 50 mM MES buffer (pH 6.0) and 2.3 ml of 1.0 mg of mouse anti-(Anti-NTproBNP peptide 63-71 antibody (Hytest., Turku, ...
Human serum albumins modified by covalently bound tolmetin or zomepirac were synthesized as models for similar products formed in vivo from acyl glucuronides. Activated esters of both drugs were prepared with 1-ethyl-3-(3-dimethylaminopropyl)-carbodi-imide, and then allowed to react with human serum albumin. Tryptic digests of both protein products were analysed by HPLC to identify peptides containing covalently bound drugs, and binding sites on albumin were identified by high-performance tandem MS. Three binding sites were common to both products, i.e. lysine-195, -199 and -351. Three further modified residues were identified for the tolmetin-albumin product, i.e. aspartic acid 1, and lysine-524 and -536. ...
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1-Cyclohexyl-1-butanol 4352-42-5 MSDS report, 1-Cyclohexyl-1-butanol MSDS safety technical specifications search, 1-Cyclohexyl-1-butanol safety information specifications ect.
Download the product note.. Biotage®PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates. Treatment of bound HOBt esters with an amine leads to amide formation in generally high purity without the need for further purification.. To date, the recommended procedure for loading PS-HOBt has required PyBroP as the coupling agent. We have developed an improved loading procedure based on the use of diisopropylcarbodiimide and DMAP. The new procedure has proven to be much more reliable, efficient, and cost effective. It requires fewer equivalents of carboxylic acid and does not require a double coupling as is the case when PyBroP is used.. Polymer-supported active esters offer some unique advantages for parallel amide synthesis. The polymer-supported active esters of PS-HOBt(HL) can be prepared using the ...
Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of a diamine cross linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.
3-ethyl-1-phenyl-4,9-dihydro-3H-beta-carboline - chemical structural formula, chemical names, chemical properties, synthesis references
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1. We used 11 different inhibitors of energy conservation as inhibitors of ATPase (adenosine triphosphatase) in extracts of Schizosaccharomyces pombe obtained from cells at different stages of the cell cycle. 2. All the inhibitors showed cell-cycle-dependent variations in their I50 values (microng of inhibitor/mg of protein giving 50% inhibition of inhibitor-sensitive ATPase at pH 8.6). 3. From the sensitivity profiles through the cell cycle it was concluded that: (a) oligomycin, venturicidin, triethyltin sulphate and dibutylchloromethyltin chloride all act at closely associated site(s); (b) NN-dicyclohexylcarbodi-imide and leucinostatin both act at a similar site, which is, however, distinct from that at which other inhibitors of the membrane factor (Fo) act. 4. The variations in I50 values for efrapeptin closely followed changes in specific activity of ATPase, as would be expected for an inhibitor acting at catalytic sites; these fluctuations were different from those for aurovertin, Dio-9, ...
CAS NO:76512-92-0; Chemical name:1H-Imidazole-4-carboximidic acid, 5-amino-1-cyclohexyl-, methyl ester ; physical and chemical property of 76512-92-0, 1H-Imidazole-4-carboximidic acid, 5-amino-1-cyclohexyl-, methyl ester is provided by ChemNet.com
The catalysis team at Solvias has been at the forefront of making the latest scientific findings available to the development of commercial catalytic processes.(1) Following the concept of modularity and scalability, Solvias is able to provide a large variety of chiral ligands. Modularity in ligand design is an important key for a successful lead finding and subsequent optimization in the development of a catalytic reaction. Only the availability of this diversity allows for evaluating variations in steric demand and electron density for a certain catalytic reaction and gaining detailed insight into the demands made on ...
The free carboxyl groups of peptides used for plate coating can be covalently linked via reaction with the water-soluble peptide coupling reagent l-ethyl-3-(3-(dimethylamino)-propy1)carbodiimide (EDC). These peptides can subsequently be linked to amino groups that are attached to the surface of microtiter plate wells. The end result is a population of peptides directly coating the surface of the microtiter plate via peptide bonds.. ...
The free carboxyl groups of peptides used for plate coating can be covalently linked via reaction with the water-soluble peptide coupling reagent l-ethyl-3-(3-(dimethylamino)-propy1)carbodiimide (EDC). These peptides can subsequently be linked to amino groups that are attached to the surface of microtiter plate wells. The end result is a population of peptides directly coating the surface of the microtiter plate via peptide bonds.. ...
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66345-08-2 - LSDVOYHPXBALRS-UHFFFAOYSA-N - Phenol, 4-cyclohexyl-2-(1,1-dimethylethyl)-6-methyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
An acid protease from Aspergillus saitoi was immobilized on agarose beads of approximately 100 micrometers diameter. Solutions of gelatin were prepared in a saturated potassium bitartrate buffer and contacted with the immobilized enzyme. The Michaelis-Menten constant was determined to be 7.8 x 10-5 M at 25°C and pH of 3.5.. The maximum velocity of hydrolysis corrected for bed voidage was found to be 6.8 x 10-7 M per second under the same conditions.. ...
57883-28-0|1-ethyl-7-nitro-3,4-dihydro-2H-quinoline|1-ethyl-7-nitro-1,2,3,4-tetrahydroquinoline|1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline
Find quality suppliers and manufacturers of 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-) for price inquiry. where to buy 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-).Also offer free database of 220119-17-5(Avermectin A1a,25-cyclohexyl-4-O-de(2,6-dideoxy-3-O-methyl-a-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-,(5Z)-) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
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BioAssay record AID 917230 submitted by ChEMBL: Open TG-GATES: Regimen: Single; Time: 6 hr; Dose: High; Route: Gavage | Dataset: Biochemistry; Assay: GLUC (Glucose); Study_ID: 554/14.
BioAssay record AID 869675 submitted by ChEMBL: Open TG-GATES: Regimen: Daily Repeat; Time: 4 day; Dose: High; Route: Gavage | Dataset: Biochemistry; Assay: GLUC (Glucose); Study_ID: 242/13.
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Purpose: To develop a sustained delivery system to improve the release kinetics of vancomycin as well as its therapeutic effectiveness to prevent postoperative corneal infection.. Methods: Vancomycin was incorporated into an engineered collagen hydrogel (10 and 15 wt%) scaffold through N-ethyl-N-[3-dimethylaminopropyl] carbodiimide/N-hydroxy succinimide (EDC/NHS) crosslinking technique. Vancomycin incorporation into the collagen hydrogel was examined by fourier transform infrared spectroscopy (FTIR) and quantified spectrophotometrically after collagen digestion with collagenase. Mechanical stability of hydrogel was measured by Instron instrument. In vitro release profile of vancomycin was measured in PBS at 37°C. Structural integrity of released vancomycin was assessed by circular dichroism (CD) spectroscopy. The minimum inhibitory concentration (MIC) of control and released vancomycin against S.aureus (SA) was determined by inoculating with bacterial suspension (106 colony-forming unit/ml). ...
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Comprehensive supplier list for Formamide, N-(1-cyclohexyl-2,2,6,6-tetramethyl-4-piperidinyl)-,Formamide, N-(1-ethenyl-5-hexenyl)-
The half-life of GLuc remains unclear. All GLuc-expressing vectors available for mammalian expression at NEB harbor the humanized codons for GLuc in which the secreted GLuc has activity similar to that of the native protein. Once GLuc is secreted into the culture medium, it is very stable. For example, ~20% of the GLuc activity was detectable after incubating a GLuc-containing sample at 99˚C for 15 minutes ...
The C-N=C=N-C core of carbodiimides (N=C=N) is linear, being related to the structure of allene. Three principal resonance ... Carbodiimides". Journal of Organic Chemistry. 43 (25): 4689-4690. doi:10.1021/jo00419a001. Pri-Bar, I.; Schwartz, J. (1997). "N ... DCC is a potent allergen and a sensitizer, often causing skin rashes.[medical citation needed] Carbodiimide Moreno, Silvia ( ... Jászay, Z. M.; Petneházy, I.; Töke, L.; Szajáni, B. (1987). "Preparation of Carbodiimides Using Phase-Transfer Catalysis". ...
An 'amidinate salt has the general structure M+[RNRCNR]− and can be accessed by reaction of a carbodiimide with an ... Ulrich, Henri (2007). Chemistry and technology of carbodiimides. Chichester, England: John Wiley & Sons. ISBN 9780470065105. ...
... hydrazination of Carbodiimides". Organometallics. 29 (22): 5946-5952. doi:10.1021/om100735q. Sarma, Rupam; Prajapati, Dipak (1 ...
In terms of bonding, isocyanates are closely related to carbon dioxide (CO2) and carbodiimides (C(NR)2). The C−N=C=O unit that ... Li, Zhen; Mayer, Robert J.; Ofial, Armin R.; Mayr, Herbert (2020-04-27). "From Carbodiimides to Carbon Dioxide: Quantification ...
N,N′-Diisopropylcarbodiimide is a carbodiimide used in peptide synthesis. As a liquid, it is easier to handle than the commonly ... "Reinvestigation of the reactions of carbodiimides with alkoxycarbonylamino acid symmetrical anhydrides : Isolation of two N- ...
Organic compounds called carbodiimides have the formula RN=C=NR. They are unrelated to imides.[citation needed] The ligand in ...
Conversely, the related carbodiimide 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is often used for solution-phase ... Carbodiimides such as dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC) are frequently used for amide bond ... A potential disadvantage of carbodiimide activation is the potential for racemization of the activated amino acid. This can be ... More recently developed and commonly-used coupling reagents omit the carbodiimide completely and incorporate the HOAt/HOBt ...
These ligands are attached to the microbubbles using carbodiimide, maleimide, or biotin-streptavidin coupling. Biotin- ...
Various carbodiimide-, hydroxybenzotriazole-, and triphenylphosphine-based couplings have been reported specifically for this ...
"Synthesis of iminoaziridines from carbodiimides and diazoesters : A new example of transition metal salt catalysed reactions of ...
Macrolactamization was performed with 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) and iPr2NEt yielded the final ...
The Ab is conjugated to the superparamagnetic iron oxide NP by different methods including the carbodiimide method. The ...
2003), "Interstellar Carbodiimide (HNCNH) - A New Astronomical Detection from the GBT PRIMOS Survey via Maser Emission Features ...
... the oligomycin sensitivity conferring protein is essential for dicyclohexyl carbodiimide-sensitive ATPase. „Biochim. Biophys. ...
... amidinium carbodiimide, is formed in primitive Earth experiments and is effective in dilute aqueous solutions. When present in ...
J. G. Moffatt, "Sulfoxide-Carbodiimide and Related Oxidations" in Oxidation vol. 2, R. L. Augustine, D. J. Trecker, Eds. ( ...
... the oligomycin sensitivity conferring protein is essential for dicyclohexyl carbodiimide-sensitive ATPase". Biochim. Biophys. ...
A simple one-step coupling can be performed using the carbodiimide crosslinker EDC to covalently attach carboxyls to primary ...
... (oxyma) is the oxime of ethyl cyanoacetate and finds use as an additive for carbodiimides, such ... carbodiimide (EDCI)). For example, the stepwise liquid-phase synthesis of the dipeptide Z-L-Phg-L-Val-OMe yields the LL-product ... together with coupling reagents such as carbodiimides (for example dicyclohexylcarbodiimide (DCC)), diisopropylcarbodiimide ( ...
1-cyclohexyl-(2-morpholinoethyl)carbodiimide metho-p-toluene sulfonate known as CMCT is another chemical that is used in ...
... the oligomycin sensitivity conferring protein is essential for dicyclohexyl carbodiimide-sensitive ATPase". Biochim. Biophys. ...
... enabling their attachment to amine-terminated surfaces through carbodiimide coupling chemistry. This process gives a high yield ...
The imine can be replaced by adding olefin to produce a cyclobutanone, carbonyl to produce a β-lactone, or carbodiimides to ...
... exists as two tautomers, one with the connectivity N≡C-NH2 and the other with the formula HN=C=NH ("carbodiimide" ...
A coupling reagent such as dicyclohexylcarbodiimide (DCC) or ethyl(dimethylaminopropyl) carbodiimide (EDC) is then added to ...
3) dicyclohexyl carbodiimide, (4) carbodiimide-containing evaporation residues formed in processes for preparing toluene ... was charged with 3 g. of diphenyl carbodiimide, 5 ml. of orthodichlorobenzene, and based upon the weight of the carbodiimide, ... More in detail, any organic carbodiimide, or a complex containing carbodiimide capable of forming an organic isocyanate under ... and carbodiimide proportion were changed where indicated in the table, which also shows conversion of carbodiimide and yield of ...
A carbodiimide or a methanediimine is a functional group consisting of the formula RN=C=NR. Carbodiimides hydrolyze to form ... Carbodiimides can also react with amines to form guanidines. The formation of an amide using a carbodiimide is straightforward ... Monagle, J. J. (1962). "Carbodiimides. III. Conversion of Isocyanates to Carbodiimides. Catalyst Studies". J. Org. Chem. 27 (11 ... Carbodiimides are formed by dehydration of ureas or from thioureas. They are also formed by treating organic isocyanates with ...
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually obtained as the ... Common uses for this carbodiimide include peptide synthesis, protein crosslinking to nucleic acids, but also in the preparation ... Nakajima, N; Ikada, Y (1995). "Mechanism of Amide Formation by Carbodiimide for Bioconjugation in Aqueous Media". Bioconjug ... "Carbodiimide EDC Induces Cross-Links That Stabilize RNase A C-dimer against Dissociation: EDC Adducts Can Affect Protein Net ...
EDAC is a zero-length crosslinker that is routinely used for the covalent binding of amine-containing ligands to carboxylated microspheres.
Biotage® PS-Carbodiimide Solid-supported Coupling Agent PS-Carbodiimide is a neutral, bound carbodiimide that can be used for ... PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. The carbodiimide ... Biotage® PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. In general, ... Biotage® PS-Carbodiimide is a neutral, bound carbodiimide for synthesis of amides and esters. Amide formation may be conducted ...
Tin(II) oxide carbodiimide and its relationship to SnO K. Dolabdjian, A. L. Görne, R. Dronskowski, M. Ströbele and H. Meyer, ...
... and phosphine P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of ... carbodiimide. compound, followed by protonolysis of the resultant amidinate. -. (phospha)guanidinate. species ". {R′NC(ER)NR′}M ... P-H bonds to carbodiimides: an efficient route to propiolamidines, guanidines, and phosphaguanidines W. Zhang and Z. Hou, Org. ... P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of which were ...
... carbodiimide. 10. The method of claim 7, wherein the carbodiimide compound is included in an amount of 0.001 to 50 wt %, with ... carbodiimide. 6. The reverse osmosis membrane of claim 1, wherein the carbodiimide compound is included in an amount of 0.001 ... High permeate flux reverse osmosis membrane including carbodiimide compound and method of manufacturing the same ... In addition, the carbodiimide compound may be included in an amount of 0.01 to 5 wt % or 0.01 to 0.5 wt %, with respect to the ...
Here, we describe a method to cross-link human recombinant collagen using a water soluble carbodiimide. Carbodiimides are ... Fabrication of a human recombinant collagen-based corneal substitute using carbodiimide chemistry. Islam, Mohammad Mirazul ... Biosynthetic corneal implant, Collagen, Carbodiimide, Collagen cross-linking, Collagen-based scaffold National Category Medical ...
Yamamoto N, Yasuda K (1977) Use of a water soluble carbodiimide as a fixing reagent. Acta Histochem Cytochem 10:14-38Google ... Carbodiimide is preferable as a fixative for the cellular localization of F-VIII-R:AG. ... The use of a carbodiimide-containing fixative for the immunohistochemical demonstration of coagulation factor VIII in rat ... Kendall PA, Polak JM, Pearse AGE (1971) Carbodiimide fixation for immunohistochemistry: observations on the fixation of ...
|p|Silia|em||span style=color: rgb(97, 169, 211);|Prep|/span||/em| Dichlorotriazine has been designed as a reagent for amide coupling applications.|/p|
Free base form of Water-soluble carbodiimide. For applications see following entry. In the presence of CuCl2, (E)- or (Z)-2- ...
P, ,P, This method involves heating organic polyisocyanates in the presence of a carbodiimide forming catalyst consisting of a ... It is thus possible to obtain a polyisocyanate containing carbodiimide groups that no longer includes catalyst and therefore ... has more the possibility that the carbodiimide formation can continue during storage of the product In a particular embodiment ... An organic polyisocyanate conversion process polyisocyanates containing carbodiimide groups. ,/ ...
... carbodiimide Hydrochloride CAS NO 25952-53-8, Europe 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride Suppliers, ... Europe 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride Manufacturers, related products of 1-Ethyl-3-(3- ... 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride. About 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide ... 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide Hydrochloride; EDAC,HCl; N-Ethyl-N-(3-dimethylaminopropyl)carbodiimide ...
The third method is a Pauson-Khand type reaction of carbodiimides and ketenimines with alkynes in an intramolecular or ... A STUDY ON SYNTHESIS OF HETEROCYCLES VIA CROSS-CONJUGATED HETEROTRIENES AND FUNCTIONALIZED CARBODIIMIDES AS KEY INTERMEDIATES. ... The method [A] includes the initial annulation by intramolecular amine-nucleophilic addition to the carbodiimide-cumulene ... 2.Tandem cyclizations strategy of functionalized carbodiimides, which were prepared by the aza-Wittig reaction of ...
名称: EDC(1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) Thermo Scientific Pierce EDC is a water-soluble ... 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC or EDAC) is a zero-length crosslinking agent used to couple ... EDC(1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride) 原装现货. ... carbodiimide crosslinker that activates carboxyl groups for spontaneous reaction with primary amines, enabling peptide ...
... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ... leads to symmetrical glycosyl carbodiimides. Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the ...
Any compound with the general formula RN=C=NR which is a formal derivative of carbodiimide Explanation of carbodiimide ... Find out information about carbodiimide. HN=C=NH An unstable tautomer of cyanamide. ... carbodiimide. Also found in: Wikipedia. carbodiimide. [¦kär·bō′dī·ə‚mīd] (organic chemistry) HN=C=NH An unstable tautomer of ... Carbodiimide , Article about carbodiimide by The Free Dictionary https://encyclopedia2.thefreedictionary.com/carbodiimide ...
... carbodiimide hydrochloride (EDC-HCl or EDAC-HCl) is a zero-length crosslinker (CAS # 25952-53-8) used to conjugate carboxyl ... carbodiimide hydrochloride (EDC-HCl). My Account , Cart Contents , Checkout ...
... carbodiimide (EDC) cross-linker to inhibit matrix metalloproteinase (MMP) activity. The hypotheses tested were that: (1) ... Substantivity of Carbodiimide Inhibition on Dentinal Enzyme Activity over Time.. *A Mazzoni. , V Angeloni. , +6 authors. L ... Carbodiimide inactivation of MMPs and effect on dentin bonding.. *. Annalisa Mazzoni. , Fabianni Magalhães Apolonio. , +8 ... Transdentinal cytotoxicity of carbodiimide (EDC) and glutaraldehyde on odontoblast-like cells.. *D L S Scheffel. , L Bianchi. ...
Fluorescent group containing carbodiimides, their precursors and methods for their production. WO1989009282A1. 22 Mar 1989. 5 ... This example illustrates a compound of the present invention wherein a dye is linked to a carbodiimide. ... or a carboxylic acid activated by a carbodiimide to form an anhydride or mixed anhydride -OCORa or OCNRaNHRb,where Ra and Rb, ... a carbodiimide, a hydroxyl, iodoacetamide, an isocyanate, an isothiocyanate, a maleimide, an NHS ester, a phosphoramidite, a ...
New polymeric carbodiimides from LANXESS provide more reliable protection for plastics against hydrolysis. Tuesday, 28. June ... With Stabaxol P 110, as with the other new carbodiimides, LANXESS is addressing the trend towards customized antihydrolysis ... New polymeric carbodiimides from LANXESS provide more reliable protection for plastics against hydrolysis ... low-emission polymeric carbodiimides based on alternative raw materials. ...
Carbodiimide inactivation of matrix metalloproteinases in radicular dentine. In: Journal of Dentistry. 2019 ; Vol. 82. pp. 56- ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ... Conclusions: Carbodiimide was effective in preserving fibre post bond strength over time, through reducing the activities of ...
Chemical Modification of Chloroplast Membranes.- A. Introduction.- B. N-ethylmaleimide (NEM).- C. Carbodiimides.- D. ...
Carbodiimide. 420-04-2. GS5950000. Carbofuran *. 1563-66-2. FB9450000. Carbolic acid. 108-95-2. SJ3325000. ...
  • In synthetic organic chemistry, compounds containing the carbodiimide functionality are dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. (wikipedia.org)
  • The formation of an amide using a carbodiimide is straightforward, but with several side reactions complicating the subject. (wikipedia.org)
  • In direct comparison to HOBt and HOAt, ethyl (hydroxyimino)cyanoacetate (Oxyma) showed a remarkable capacity to inhibit racemization as an additive in carbodiimide mediated amide bond formation. (sigmaaldrich.com)
  • Room temperature treatment of SLGO with carbodiimides leads to the collapse of the individual sheets into star-like clusters that exhibited poor subsequent reactivity with amines (c. 3-5% conversion of the intermediate to the final amide). (wikipedia.org)
  • Single strands of DNA can then be modified with an added amino group in order to covalently bond to the carboxyl group, due to an amide bond formed between the carboxyl and amino groups in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). (wikipedia.org)
  • During the operation of processes of this type a relatively large proportion of impurities such as polyureas, carbodiimides, biurets, isocyanate polymers, and the like are formed in the various process streams. (google.com)
  • The presence of organic carbodiimide type impurities in organic isocyanates is undesirable because it ties up valuable moieties capable of forming the desired isocyanate. (google.com)
  • It has now been discovered that the foregoing objects are accomplished when an organic carbodiimide is reacted with carbon monoxide and/ or carbon dioxide in the presence of a catalyst at an elevated pressure and elevated temperature to produce an organic isocyanate. (google.com)
  • More in detail, any organic carbodiimide, or a complex containing carbodiimide capable of forming an organic isocyanate under the reaction conditions applied may be employed as a reactant in the process of this invention. (google.com)
  • Il est ainsi possible d'obtenir un polyisocyanate contenant des groupes carbodiimide qui ne comporte plus de catalyseur et qui ne comporte donc plus la possibilité que la formation de carbodiimide puisse se poursuivre lors du stockage du produit Dans un mode de réalisation particulier, on utilise le procédé pour transformer le méthylènebis-(isocyanate de phényle) qui est normalement solide aux températures ambiantes. (google.com)
  • 1. A E. coli ST enterotoxin derivative which consists in E. coli enterotoxin crosslinked with a dialdehyde, a di-ketone, a carbodiimide, an isocyanate, an epihalohydrin or adifluoride. (patentgenius.com)
  • Coupling of substances containing a primary amine to hyaluronan via carbodiimide-mediated amidation (Thesis). (wikipedia.org)
  • In general, PS-Carbodiimide was found to synthesize amides in high yield and purity without evidence of residual amine or carboxylic acid. (biotage.com)
  • Amine (1.0 equivalent) and acid (1.5 equivalent) in DCM (with 10% DMF added if necessary) was added to a dry reaction vessel and the mixture stirred for 10 min prior to addition of PS-Carbodiimide resin (2 equivalents) with a reaction solvent volume of 10 mL/g resin. (biotage.com)
  • Various metal complexes ( e.g. , lanthanides, early transition metals, and alkali metals ) can serve as catalyst precursors for the catalytic addition of alkyne C-H, amine N-H, and phosphine P-H bonds to carbodiimides, to give a new family of propiolamidines, guanidines, and phophaguanidines, some of which were difficult to prepare previously. (rsc.org)
  • and forming a polyamide active layer on the porous support by interfacially polymerizing a polyfunctional amine solution including a carbodiimide compound, and a polyfunctional acid halide compound solution. (freepatentsonline.com)
  • 6. The reverse osmosis membrane of claim 1, wherein the carbodiimide compound is included in an amount of 0.001 to 50 wt %, with respect to 100 w % of the polyfunctional amine solution. (freepatentsonline.com)
  • The method [A] includes the initial annulation by intramolecular amine-nucleophilic addition to the carbodiimide-cumulene carbon, followed by the second cyclization by reacting a group of newly formed amine with an inner functional group arranged. (nii.ac.jp)
  • 11. The method of claim 10 wherein the crosslinking agent comprises a material selected from the group consisting of formaldehydes, dialdehyde starches, carbodiimides and glutaraldehydes. (google.com)
  • Nevertheless, we have shown that epoxy cross-linkers should be further explored in the fabrication of collagen-based hydrogels, as alternatives to or in conjunction with carbodiimide cross-linkers. (mdpi.com)
  • Carbodiimide was used to strengthen the scaffold structure which made from gelatin mixed with carboxymethylcellulose (CMC) using freeze drying method. (cetjournal.it)
  • Carbodiimides are formed by dehydration of ureas or from thioureas. (wikipedia.org)
  • Readily accessible unsymmetrical N,N′-bis(glycosyl)thioureas can be desulfurated and transformed into the corresponding carbodiimides using HgO in CHCl 3 /water at room temperature. (elsevier.com)
  • Addition of bis(trimethylsilyl)carbodiimide to peracetylated aldoses under the influence of SnCl 4 afforded N,N-bis(glycosyl)cyanamides for the first time. (elsevier.com)
  • Cologne - The LANXESS Rhein Chemie Additives (ADD) business unit is expanding its large product range of hydrolysis stabilizers for plastics and polyurethanes with the addition of Stabaxol P 110, the first product in a new line of innovative, low-emission polymeric carbodiimides based on alternative raw materials. (lanxess.com)
  • The C-N=C=N-C core of carbodiimides (N=C=N) is linear, being related to the structure of allene. (wikipedia.org)